id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017817-ztp7w9yh	Land, Walter Gottlieb	Cell-Autonomous (Cell-Intrinsic) Stress Responses	2018-03-28		.txt	text/plain	17727	855	40	Autophagy is an evolutionarily highly conserved self-digestive process in response to environmental stress to eukaryotic cells, by which cytoplasmic components such as defective/damaged or redundant organelles or protein aggregates are delivered to the lysosome for recycling and degradation. More recent studies then revealed that these transcription factors, notably Nrf2, are activated by Keap1 as the primary negative regulator of Nrf2, that is, a molecule that simultaneously operates as a sensor protein able to perceive dyshomeostatic Subclass IIC-4 DAMPs, for example, in terms of redox changes reflecting electrophilic stress. Strikingly, a complex relationship reportedly exists between autophagy and DAMPs in cellular adaption to stress and injury and cell death characterized by a crosstalk between autophagy induction and secretion or release of DAMPs. In fact, growing evidence indicates that autophagic mechanisms are involved in regulating release and degradation of DAMPs including CALR, HMGB1, ATP, and DNA in several cell types [37, 148, 175] .	./cache/cord-017817-ztp7w9yh.txt	./txt/cord-017817-ztp7w9yh.txt