id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005607-b1a39hhw	Bellingan, G	Leukocytes: friend or foe	2000		.txt	text/plain	3827	173	37	Over the last three decades we have gained significant insights into leukocyte activation, recruitment and mediator secretion and the contribution of these agents to both the onset and resolution of sepsis and inflammation.¶The body relies on the inflammatory response for protection. A direct consequence of this protective strategy is that the inflammatory response may be inadequate, with the risk of overwhelming sepsis, or excessive, leading to rampant systemic inflammation and consequent multiple organ damage.¶It is now becoming apparent however that in addition to leukocytes other cells have important roles both in defence against invading pathogens and in driving malignant inflammation. Endothelial cells, mesothelial cells, fibroblasts and epithelial cells are also all involved not only with their capacity to drive the inflammatory response through mediator generation but also in innate immune defences including through the production of antimicrobial proteins.	./cache/cord-005607-b1a39hhw.txt	./txt/cord-005607-b1a39hhw.txt