id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280857-0o1ikwks	Goligher, Ewan C.	Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort	2020-11-02		.txt	text/plain	6146	274	25	This review summarizes practical strategies for achieving lung and diaphragm-protective targets at the bedside, focusing on inspiratory and expiratory ventilator settings, monitoring of inspiratory effort or respiratory drive, management of dyssynchrony, and sedation considerations. Several strategies can be used to facilitate lung and diaphragm protective ventilation, including modulation of ventilator inspiratory and expiratory assist, drugs that modify respiratory drive and/or effort, extracorporeal CO 2 removal (ECCO 2 R) and electrical stimulation of the respiratory muscles, as shown in Fig. 2 . [7] also showed that higher ECCO 2 R support reduced P 0.1 , respiratory muscle effort, and transpulmonary pressure in spontaneously breathing patients recovering from severe ARDS [74] . These preliminary findings suggest that partial neuromuscular blockade could be a feasible approach to achieving lung and diaphragm-protective ventilation targets in patients with high respiratory effort.	./cache/cord-280857-0o1ikwks.txt	./txt/cord-280857-0o1ikwks.txt