id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268038-9jjpc1a2	Boukhvalova, M	Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus	2015-09-14		.txt	text/plain	4354	230	37	These results indicate the potential of RI-002 to improve outcome of RSV infection in immunocompromised subjects not only by controlling viral replication, but also by reducing damage to lung parenchyma and epithelial airway lining, but further studies are needed. In this case, treatment with a drug that has strong antiviral activity may have a higher therapeutic efficacy in immunosuppressed patients compared with immunocompetent individuals infected with RSV because of the reduction in pulmonary damage caused by excessive viral replication. Although normal cotton rats treated with saline cleared RSV by day 10 post infection, immunosuppressed saline-treated animals had~6 log 10 PFU of virus in their lungs and noses at that time. To determine whether RI-002 has an effect on pulmonary pathology associated with prolonged RSV replication in immunosuppressed animals, lung tissue was collected for histopathology analysis on day 10 post infection.	./cache/cord-268038-9jjpc1a2.txt	./txt/cord-268038-9jjpc1a2.txt