id author title date pages extension mime words sentences flesch summary cache txt cord-256788-h4iv8crq Sumino, Kaharu Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life 2012-03-27 .txt text/plain 5026 238 47 9 In that regard a decrease in IFN-g production from cord blood mononuclear cells (CBMCs) stimulated by PHA or allergens has been associated with increased risk for acute respiratory tract illness during infancy. We assessed whether each of these immune end points could predict the development of respiratory tract illness during the first year of life in a prospective birth cohort of children at high risk for asthma and allergic disease. Together, these findings reinforce the association of a decreased IFN-g response to RSV with the development of increased viral respiratory tract infections in the first year of life. In this study we provide evidence that a decreased antiviral interferon response at the time of birth is selectively associated with an increase in acute respiratory tract infections in the first year of life among infants at high risk for asthma and allergic disease. ./cache/cord-256788-h4iv8crq.txt ./txt/cord-256788-h4iv8crq.txt