id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253145-1fbj1rdv	Fox, Julie D.	Nucleic acid amplification tests for detection of respiratory viruses	2007-10-31		.txt	text/plain	5391	270	40	Assays based on nucleic acid amplification and detection can be designed against a broad range of respiratory viruses and have been particularly useful for detection of recently identified viruses such as human metapneumovirus and coronaviruses NL63 and HKU1. Use of NATs allows assessment of the impact of a wider array of potential pathogens on respiratory infections than previously possible and target-specific (multiplex) approaches have proved feasible for enhanced broadspectrum respiratory virus diagnosis. Many feasibility studies have confirmed that NATs improve detection of potential pathogens from lower respiratory tract specimens as well as from respiratory swabs even where alternative methods such as DFA and culture are available (Hibbitts and Fox, 2002; Moore et al., 2004; Lee et al., 2006) . If individual NATs are utilized, multiple infections are identified frequently but use of real-time multiplex reactions may lead to competition between amplification and detection Table 1 Enhanced detection of respiratory viruses using NATs	./cache/cord-253145-1fbj1rdv.txt	./txt/cord-253145-1fbj1rdv.txt