id	sid	tid	token	lemma	pos
cord-183197-dxmto1tu	1	1	key	key	NN
cord-183197-dxmto1tu	1	2	:	:	:
cord-183197-dxmto1tu	1	3	cord-183197-dxmto1tu	cord-183197-dxmto1tu	.
cord-183197-dxmto1tu	2	1	authors	author	NNS
cord-183197-dxmto1tu	2	2	:	:	:
cord-183197-dxmto1tu	2	3	Zhao	Zhao	NNP
cord-183197-dxmto1tu	2	4	,	,	,
cord-183197-dxmto1tu	2	5	Tom	Tom	NNP
cord-183197-dxmto1tu	2	6	Y.	Y.	NNP
cord-183197-dxmto1tu	2	7	;	;	:
cord-183197-dxmto1tu	3	1	Patankar	Patankar	NNP
cord-183197-dxmto1tu	3	2	,	,	,
cord-183197-dxmto1tu	3	3	Neelesh	Neelesh	NNP
cord-183197-dxmto1tu	3	4	A.	a.	NN
cord-183197-dxmto1tu	3	5	title	title	NN
cord-183197-dxmto1tu	3	6	:	:	:
cord-183197-dxmto1tu	3	7	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	3	8	as	as	IN
cord-183197-dxmto1tu	3	9	an	an	DT
cord-183197-dxmto1tu	3	10	inhibitor	inhibitor	NN
cord-183197-dxmto1tu	3	11	to	to	IN
cord-183197-dxmto1tu	3	12	the	the	DT
cord-183197-dxmto1tu	3	13	coronavirus	coronavirus	NN
cord-183197-dxmto1tu	3	14	SARS	SARS	NNP
cord-183197-dxmto1tu	3	15	-	-	HYPH
cord-183197-dxmto1tu	3	16	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	3	17	date	date	NN
cord-183197-dxmto1tu	3	18	:	:	:
cord-183197-dxmto1tu	4	1	2020	2020	CD
cord-183197-dxmto1tu	4	2	-	-	SYM
cord-183197-dxmto1tu	4	3	08	08	CD
cord-183197-dxmto1tu	4	4	-	-	SYM
cord-183197-dxmto1tu	4	5	13	13	CD
cord-183197-dxmto1tu	4	6	journal	journal	NN
cord-183197-dxmto1tu	4	7	:	:	:
cord-183197-dxmto1tu	5	1	nan	nan	NNP
cord-183197-dxmto1tu	5	2	DOI	DOI	NNP
cord-183197-dxmto1tu	5	3	:	:	:
cord-183197-dxmto1tu	5	4	nan	nan	NNP
cord-183197-dxmto1tu	5	5	sha	sha	NNP
cord-183197-dxmto1tu	5	6	:	:	:
cord-183197-dxmto1tu	6	1	f222e7a05c6ff4c861e032736e7c6077ac4f05ec	f222e7a05c6ff4c861e032736e7c6077ac4f05ec	DT
cord-183197-dxmto1tu	6	2	doc_id	doc_id	CD
cord-183197-dxmto1tu	7	1	:	:	:
cord-183197-dxmto1tu	7	2	183197	183197	CD
cord-183197-dxmto1tu	7	3	cord_uid	cord_uid	NNS
cord-183197-dxmto1tu	7	4	:	:	:
cord-183197-dxmto1tu	8	1	dxmto1tu	dxmto1tu	NNP
cord-183197-dxmto1tu	9	1	The	the	DT
cord-183197-dxmto1tu	9	2	coronavirus	coronavirus	NN
cord-183197-dxmto1tu	9	3	SARS	SARS	NNP
cord-183197-dxmto1tu	9	4	-	-	HYPH
cord-183197-dxmto1tu	9	5	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	9	6	remains	remain	VBZ
cord-183197-dxmto1tu	9	7	an	an	DT
cord-183197-dxmto1tu	9	8	extant	extant	JJ
cord-183197-dxmto1tu	9	9	threat	threat	NN
cord-183197-dxmto1tu	9	10	against	against	IN
cord-183197-dxmto1tu	9	11	public	public	JJ
cord-183197-dxmto1tu	9	12	health	health	NN
cord-183197-dxmto1tu	9	13	on	on	IN
cord-183197-dxmto1tu	9	14	a	a	DT
cord-183197-dxmto1tu	9	15	global	global	JJ
cord-183197-dxmto1tu	9	16	scale	scale	NN
cord-183197-dxmto1tu	9	17	.	.	.
cord-183197-dxmto1tu	10	1	Cell	cell	NN
cord-183197-dxmto1tu	10	2	infection	infection	NN
cord-183197-dxmto1tu	10	3	begins	begin	VBZ
cord-183197-dxmto1tu	10	4	when	when	WRB
cord-183197-dxmto1tu	10	5	the	the	DT
cord-183197-dxmto1tu	10	6	spike	spike	NN
cord-183197-dxmto1tu	10	7	protein	protein	NN
cord-183197-dxmto1tu	10	8	of	of	IN
cord-183197-dxmto1tu	10	9	SARS	SARS	NNP
cord-183197-dxmto1tu	10	10	-	-	HYPH
cord-183197-dxmto1tu	10	11	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	10	12	binds	bind	VBZ
cord-183197-dxmto1tu	10	13	with	with	IN
cord-183197-dxmto1tu	10	14	the	the	DT
cord-183197-dxmto1tu	10	15	cell	cell	NN
cord-183197-dxmto1tu	10	16	receptor	receptor	NN
cord-183197-dxmto1tu	10	17	,	,	,
cord-183197-dxmto1tu	10	18	angiotensin	angiotensin	NN
cord-183197-dxmto1tu	10	19	-	-	HYPH
cord-183197-dxmto1tu	10	20	converting	convert	VBG
cord-183197-dxmto1tu	10	21	enzyme	enzyme	NN
cord-183197-dxmto1tu	10	22	2	2	CD
cord-183197-dxmto1tu	10	23	(	(	-LRB-
cord-183197-dxmto1tu	10	24	ACE2	ACE2	NNP
cord-183197-dxmto1tu	10	25	)	)	-RRB-
cord-183197-dxmto1tu	10	26	.	.	.
cord-183197-dxmto1tu	11	1	Here	here	RB
cord-183197-dxmto1tu	11	2	,	,	,
cord-183197-dxmto1tu	11	3	we	-PRON-	PRP
cord-183197-dxmto1tu	11	4	address	address	VBP
cord-183197-dxmto1tu	11	5	the	the	DT
cord-183197-dxmto1tu	11	6	role	role	NN
cord-183197-dxmto1tu	11	7	of	of	IN
cord-183197-dxmto1tu	11	8	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	11	9	as	as	IN
cord-183197-dxmto1tu	11	10	an	an	DT
cord-183197-dxmto1tu	11	11	inhibitor	inhibitor	NN
cord-183197-dxmto1tu	11	12	for	for	IN
cord-183197-dxmto1tu	11	13	the	the	DT
cord-183197-dxmto1tu	11	14	receptor	receptor	NN
cord-183197-dxmto1tu	11	15	-	-	HYPH
cord-183197-dxmto1tu	11	16	binding	bind	VBG
cord-183197-dxmto1tu	11	17	domain	domain	NN
cord-183197-dxmto1tu	11	18	(	(	-LRB-
cord-183197-dxmto1tu	11	19	RBD	RBD	NNP
cord-183197-dxmto1tu	11	20	)	)	-RRB-
cord-183197-dxmto1tu	11	21	of	of	IN
cord-183197-dxmto1tu	11	22	the	the	DT
cord-183197-dxmto1tu	11	23	spike	spike	NN
cord-183197-dxmto1tu	11	24	protein	protein	NN
cord-183197-dxmto1tu	11	25	.	.	.
cord-183197-dxmto1tu	12	1	Targeted	targeted	JJ
cord-183197-dxmto1tu	12	2	molecular	molecular	JJ
cord-183197-dxmto1tu	12	3	investigation	investigation	NN
cord-183197-dxmto1tu	12	4	show	show	VBP
cord-183197-dxmto1tu	12	5	that	that	IN
cord-183197-dxmto1tu	12	6	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	12	7	binds	bind	VBZ
cord-183197-dxmto1tu	12	8	more	more	RBR
cord-183197-dxmto1tu	12	9	favorably	favorably	RB
cord-183197-dxmto1tu	12	10	to	to	IN
cord-183197-dxmto1tu	12	11	the	the	DT
cord-183197-dxmto1tu	12	12	RBD	RBD	NNP
cord-183197-dxmto1tu	12	13	(	(	-LRB-
cord-183197-dxmto1tu	12	14	-9.40	-9.40	CD
cord-183197-dxmto1tu	12	15	kcal	kcal	NNP
cord-183197-dxmto1tu	12	16	/	/	SYM
cord-183197-dxmto1tu	12	17	mol	mol	NN
cord-183197-dxmto1tu	12	18	)	)	-RRB-
cord-183197-dxmto1tu	12	19	compared	compare	VBN
cord-183197-dxmto1tu	12	20	to	to	IN
cord-183197-dxmto1tu	12	21	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	12	22	(	(	-LRB-
cord-183197-dxmto1tu	12	23	-6.31	-6.31	CD
cord-183197-dxmto1tu	12	24	kcal	kcal	NNP
cord-183197-dxmto1tu	12	25	/	/	SYM
cord-183197-dxmto1tu	12	26	mol	mol	NN
cord-183197-dxmto1tu	12	27	)	)	-RRB-
cord-183197-dxmto1tu	12	28	or	or	CC
cord-183197-dxmto1tu	12	29	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	12	30	(	(	-LRB-
cord-183197-dxmto1tu	12	31	-8.08	-8.08	CD
cord-183197-dxmto1tu	12	32	kcal	kcal	NNP
cord-183197-dxmto1tu	12	33	/	/	SYM
cord-183197-dxmto1tu	12	34	mol	mol	NN
cord-183197-dxmto1tu	12	35	)	)	-RRB-
cord-183197-dxmto1tu	12	36	and	and	CC
cord-183197-dxmto1tu	12	37	inhibits	inhibit	VBZ
cord-183197-dxmto1tu	12	38	attachment	attachment	NN
cord-183197-dxmto1tu	12	39	to	to	IN
cord-183197-dxmto1tu	12	40	ACE2	ACE2	NNP
cord-183197-dxmto1tu	12	41	to	to	IN
cord-183197-dxmto1tu	12	42	a	a	DT
cord-183197-dxmto1tu	12	43	greater	great	JJR
cord-183197-dxmto1tu	12	44	degree	degree	NN
cord-183197-dxmto1tu	12	45	(	(	-LRB-
cord-183197-dxmto1tu	12	46	binding	bind	VBG
cord-183197-dxmto1tu	12	47	efficiency	efficiency	NN
cord-183197-dxmto1tu	12	48	of	of	IN
cord-183197-dxmto1tu	12	49	2.98	2.98	CD
cord-183197-dxmto1tu	12	50	$	$	$
cord-183197-dxmto1tu	13	1	frac{text{kcal}}{text{mol}cdot	frac{text{kcal}}{text{mol}cdot	NN
cord-183197-dxmto1tu	13	2	text{nm}^2}$	text{nm}^2}$	JJ
cord-183197-dxmto1tu	13	3	for	for	IN
cord-183197-dxmto1tu	13	4	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	13	5	-	-	HYPH
cord-183197-dxmto1tu	13	6	RBD	RBD	NNP
cord-183197-dxmto1tu	13	7	,	,	,
cord-183197-dxmto1tu	13	8	5.59	5.59	CD
cord-183197-dxmto1tu	13	9	$	$	$
cord-183197-dxmto1tu	14	1	frac{text{kcal}}{text{mol}cdot	frac{text{kcal}}{text{mol}cdot	NN
cord-183197-dxmto1tu	14	2	text{nm}^2}$	text{nm}^2}$	JJ
cord-183197-dxmto1tu	14	3	for	for	IN
cord-183197-dxmto1tu	14	4	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	14	5	-	-	HYPH
cord-183197-dxmto1tu	14	6	RBD	RBD	NNP
cord-183197-dxmto1tu	14	7	,	,	,
cord-183197-dxmto1tu	14	8	5.16	5.16	CD
cord-183197-dxmto1tu	14	9	$	$	$
cord-183197-dxmto1tu	15	1	frac{text{kcal}}{text{mol}cdot	frac{text{kcal}}{text{mol}cdot	NN
cord-183197-dxmto1tu	15	2	text{nm}^2}$	text{nm}^2}$	JJ
cord-183197-dxmto1tu	15	3	for	for	IN
cord-183197-dxmto1tu	15	4	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	15	5	-	-	HYPH
cord-183197-dxmto1tu	15	6	RBD	RBD	NNP
cord-183197-dxmto1tu	15	7	)	)	-RRB-
cord-183197-dxmto1tu	15	8	.	.	.
cord-183197-dxmto1tu	16	1	Stronger	strong	JJR
cord-183197-dxmto1tu	16	2	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	16	3	inhibition	inhibition	NN
cord-183197-dxmto1tu	16	4	is	be	VBZ
cord-183197-dxmto1tu	16	5	verified	verify	VBN
cord-183197-dxmto1tu	16	6	with	with	IN
cord-183197-dxmto1tu	16	7	nonequilibrium	nonequilibrium	JJ
cord-183197-dxmto1tu	16	8	PMF	PMF	NNP
cord-183197-dxmto1tu	16	9	calculations	calculation	NNS
cord-183197-dxmto1tu	16	10	,	,	,
cord-183197-dxmto1tu	16	11	for	for	IN
cord-183197-dxmto1tu	16	12	which	which	WDT
cord-183197-dxmto1tu	16	13	the	the	DT
cord-183197-dxmto1tu	16	14	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	16	15	-	-	HYPH
cord-183197-dxmto1tu	16	16	RBD	RBD	NNP
cord-183197-dxmto1tu	16	17	complex	complex	NN
cord-183197-dxmto1tu	16	18	exhibits	exhibit	VBZ
cord-183197-dxmto1tu	16	19	the	the	DT
cord-183197-dxmto1tu	16	20	lowest	low	JJS
cord-183197-dxmto1tu	16	21	free	free	JJ
cord-183197-dxmto1tu	16	22	energy	energy	NN
cord-183197-dxmto1tu	16	23	profile	profile	NN
cord-183197-dxmto1tu	16	24	along	along	IN
cord-183197-dxmto1tu	16	25	the	the	DT
cord-183197-dxmto1tu	16	26	dissociation	dissociation	NN
cord-183197-dxmto1tu	16	27	pathway	pathway	NN
cord-183197-dxmto1tu	16	28	from	from	IN
cord-183197-dxmto1tu	16	29	ACE2	ACE2	NNP
cord-183197-dxmto1tu	16	30	.	.	.
cord-183197-dxmto1tu	17	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	17	2	appears	appear	VBZ
cord-183197-dxmto1tu	17	3	to	to	TO
cord-183197-dxmto1tu	17	4	target	target	VB
cord-183197-dxmto1tu	17	5	viral	viral	JJ
cord-183197-dxmto1tu	17	6	residues	residue	NNS
cord-183197-dxmto1tu	17	7	that	that	WDT
cord-183197-dxmto1tu	17	8	are	be	VBP
cord-183197-dxmto1tu	17	9	usually	usually	RB
cord-183197-dxmto1tu	17	10	involved	involve	VBN
cord-183197-dxmto1tu	17	11	in	in	IN
cord-183197-dxmto1tu	17	12	significant	significant	JJ
cord-183197-dxmto1tu	17	13	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	17	14	bonding	bonding	NN
cord-183197-dxmto1tu	17	15	with	with	IN
cord-183197-dxmto1tu	17	16	ACE2	ACE2	NNP
cord-183197-dxmto1tu	17	17	;	;	:
cord-183197-dxmto1tu	17	18	this	this	DT
cord-183197-dxmto1tu	17	19	inhibition	inhibition	NN
cord-183197-dxmto1tu	17	20	of	of	IN
cord-183197-dxmto1tu	17	21	cellular	cellular	JJ
cord-183197-dxmto1tu	17	22	infection	infection	NN
cord-183197-dxmto1tu	17	23	complements	complement	VBZ
cord-183197-dxmto1tu	17	24	the	the	DT
cord-183197-dxmto1tu	17	25	anti	anti	JJ
cord-183197-dxmto1tu	17	26	-	-	JJ
cord-183197-dxmto1tu	17	27	inflammatory	inflammatory	JJ
cord-183197-dxmto1tu	17	28	and	and	CC
cord-183197-dxmto1tu	17	29	cytokine	cytokine	JJ
cord-183197-dxmto1tu	17	30	suppressing	suppress	VBG
cord-183197-dxmto1tu	17	31	capability	capability	NN
cord-183197-dxmto1tu	17	32	of	of	IN
cord-183197-dxmto1tu	17	33	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	17	34	,	,	,
cord-183197-dxmto1tu	17	35	and	and	CC
cord-183197-dxmto1tu	17	36	may	may	MD
cord-183197-dxmto1tu	17	37	further	further	RB
cord-183197-dxmto1tu	17	38	reduce	reduce	VB
cord-183197-dxmto1tu	17	39	the	the	DT
cord-183197-dxmto1tu	17	40	duration	duration	NN
cord-183197-dxmto1tu	17	41	of	of	IN
cord-183197-dxmto1tu	17	42	ICU	ICU	NNP
cord-183197-dxmto1tu	17	43	stays	stay	VBZ
cord-183197-dxmto1tu	17	44	and	and	CC
cord-183197-dxmto1tu	17	45	mechanical	mechanical	JJ
cord-183197-dxmto1tu	17	46	ventilation	ventilation	NN
cord-183197-dxmto1tu	17	47	induced	induce	VBN
cord-183197-dxmto1tu	17	48	by	by	IN
cord-183197-dxmto1tu	17	49	the	the	DT
cord-183197-dxmto1tu	17	50	coronavirus	coronavirus	NN
cord-183197-dxmto1tu	17	51	SARS	SARS	NNP
cord-183197-dxmto1tu	17	52	-	-	HYPH
cord-183197-dxmto1tu	17	53	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	17	54	.	.	.
cord-183197-dxmto1tu	18	1	The	the	DT
cord-183197-dxmto1tu	18	2	extreme	extreme	JJ
cord-183197-dxmto1tu	18	3	urgency	urgency	NN
cord-183197-dxmto1tu	18	4	for	for	IN
cord-183197-dxmto1tu	18	5	therapeutics	therapeutic	NNS
cord-183197-dxmto1tu	18	6	against	against	IN
cord-183197-dxmto1tu	18	7	the	the	DT
cord-183197-dxmto1tu	18	8	acute	acute	JJ
cord-183197-dxmto1tu	18	9	respiratory	respiratory	JJ
cord-183197-dxmto1tu	18	10	syndrome	syndrome	NN
cord-183197-dxmto1tu	18	11	coronavirus	coronavirus	NN
cord-183197-dxmto1tu	18	12	2	2	CD
cord-183197-dxmto1tu	19	1	(	(	-LRB-
cord-183197-dxmto1tu	19	2	SARS	SARS	NNP
cord-183197-dxmto1tu	19	3	-	-	HYPH
cord-183197-dxmto1tu	19	4	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	19	5	)	)	-RRB-
cord-183197-dxmto1tu	19	6	drives	drive	VBZ
cord-183197-dxmto1tu	19	7	the	the	DT
cord-183197-dxmto1tu	19	8	review	review	NN
cord-183197-dxmto1tu	19	9	of	of	IN
cord-183197-dxmto1tu	19	10	existing	exist	VBG
cord-183197-dxmto1tu	19	11	drugs	drug	NNS
cord-183197-dxmto1tu	19	12	for	for	IN
cord-183197-dxmto1tu	19	13	their	-PRON-	PRP$
cord-183197-dxmto1tu	19	14	ability	ability	NN
cord-183197-dxmto1tu	19	15	to	to	TO
cord-183197-dxmto1tu	19	16	inhibit	inhibit	VB
cord-183197-dxmto1tu	19	17	the	the	DT
cord-183197-dxmto1tu	19	18	function	function	NN
cord-183197-dxmto1tu	19	19	of	of	IN
cord-183197-dxmto1tu	19	20	this	this	DT
cord-183197-dxmto1tu	19	21	virus	virus	NN
cord-183197-dxmto1tu	19	22	1;2	1;2	CD
cord-183197-dxmto1tu	19	23	.	.	.
cord-183197-dxmto1tu	20	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	20	2	has	have	VBZ
cord-183197-dxmto1tu	20	3	been	be	VBN
cord-183197-dxmto1tu	20	4	proposed	propose	VBN
cord-183197-dxmto1tu	20	5	as	as	IN
cord-183197-dxmto1tu	20	6	a	a	DT
cord-183197-dxmto1tu	20	7	strong	strong	JJ
cord-183197-dxmto1tu	20	8	candidate	candidate	NN
cord-183197-dxmto1tu	20	9	against	against	IN
cord-183197-dxmto1tu	20	10	SARS	SARS	NNP
cord-183197-dxmto1tu	20	11	-	-	HYPH
cord-183197-dxmto1tu	20	12	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	20	13	3	3	CD
cord-183197-dxmto1tu	20	14	due	due	JJ
cord-183197-dxmto1tu	20	15	to	to	IN
cord-183197-dxmto1tu	20	16	its	-PRON-	PRP$
cord-183197-dxmto1tu	20	17	lipophilic	lipophilic	JJ
cord-183197-dxmto1tu	20	18	nature	nature	NN
cord-183197-dxmto1tu	20	19	,	,	,
cord-183197-dxmto1tu	20	20	anti	anti	JJ
cord-183197-dxmto1tu	20	21	-	-	JJ
cord-183197-dxmto1tu	20	22	inflammatory	inflammatory	JJ
cord-183197-dxmto1tu	20	23	response	response	NN
cord-183197-dxmto1tu	20	24	,	,	,
cord-183197-dxmto1tu	20	25	as	as	RB
cord-183197-dxmto1tu	20	26	well	well	RB
cord-183197-dxmto1tu	20	27	as	as	IN
cord-183197-dxmto1tu	20	28	its	-PRON-	PRP$
cord-183197-dxmto1tu	20	29	ability	ability	NN
cord-183197-dxmto1tu	20	30	to	to	TO
cord-183197-dxmto1tu	20	31	chelate	chelate	VB
cord-183197-dxmto1tu	20	32	zinc	zinc	NN
cord-183197-dxmto1tu	20	33	species	specie	NNS
cord-183197-dxmto1tu	20	34	on	on	IN
cord-183197-dxmto1tu	20	35	matrix	matrix	NN
cord-183197-dxmto1tu	20	36	metalloproteinases	metalloproteinase	NNS
cord-183197-dxmto1tu	20	37	(	(	-LRB-
cord-183197-dxmto1tu	20	38	MMPs	MMPs	NNP
cord-183197-dxmto1tu	20	39	)	)	-RRB-
cord-183197-dxmto1tu	20	40	.	.	.
cord-183197-dxmto1tu	21	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	21	2	class	class	NN
cord-183197-dxmto1tu	21	3	antibiotics	antibiotic	NNS
cord-183197-dxmto1tu	21	4	have	have	VBP
cord-183197-dxmto1tu	21	5	also	also	RB
cord-183197-dxmto1tu	21	6	been	be	VBN
cord-183197-dxmto1tu	21	7	shown	show	VBN
cord-183197-dxmto1tu	21	8	to	to	TO
cord-183197-dxmto1tu	21	9	be	be	VB
cord-183197-dxmto1tu	21	10	effective	effective	JJ
cord-183197-dxmto1tu	21	11	in	in	IN
cord-183197-dxmto1tu	21	12	reducing	reduce	VBG
cord-183197-dxmto1tu	21	13	the	the	DT
cord-183197-dxmto1tu	21	14	duration	duration	NN
cord-183197-dxmto1tu	21	15	of	of	IN
cord-183197-dxmto1tu	21	16	ventilatory	ventilatory	JJ
cord-183197-dxmto1tu	21	17	support	support	NN
cord-183197-dxmto1tu	21	18	and	and	CC
cord-183197-dxmto1tu	21	19	ICU	ICU	NNP
cord-183197-dxmto1tu	21	20	stay	stay	VBP
cord-183197-dxmto1tu	21	21	from	from	IN
cord-183197-dxmto1tu	21	22	acute	acute	JJ
cord-183197-dxmto1tu	21	23	respiratory	respiratory	JJ
cord-183197-dxmto1tu	21	24	distress	distress	NN
cord-183197-dxmto1tu	21	25	syndrome	syndrome	NN
cord-183197-dxmto1tu	21	26	5	5	CD
cord-183197-dxmto1tu	21	27	,	,	,
cord-183197-dxmto1tu	21	28	and	and	CC
cord-183197-dxmto1tu	21	29	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	21	30	has	have	VBZ
cord-183197-dxmto1tu	21	31	been	be	VBN
cord-183197-dxmto1tu	21	32	suggested	suggest	VBN
cord-183197-dxmto1tu	21	33	to	to	TO
cord-183197-dxmto1tu	21	34	be	be	VB
cord-183197-dxmto1tu	21	35	an	an	DT
cord-183197-dxmto1tu	21	36	important	important	JJ
cord-183197-dxmto1tu	21	37	component	component	NN
cord-183197-dxmto1tu	21	38	in	in	IN
cord-183197-dxmto1tu	21	39	combination	combination	NN
cord-183197-dxmto1tu	21	40	therapy	therapy	NN
cord-183197-dxmto1tu	21	41	for	for	IN
cord-183197-dxmto1tu	21	42	its	-PRON-	PRP$
cord-183197-dxmto1tu	21	43	anti	anti	JJ
cord-183197-dxmto1tu	21	44	-	-	JJ
cord-183197-dxmto1tu	21	45	viral	viral	JJ
cord-183197-dxmto1tu	21	46	properties	property	NNS
cord-183197-dxmto1tu	21	47	6	6	CD
cord-183197-dxmto1tu	21	48	.	.	.
cord-183197-dxmto1tu	22	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	22	2	as	as	RB
cord-183197-dxmto1tu	22	3	well	well	RB
cord-183197-dxmto1tu	22	4	as	as	IN
cord-183197-dxmto1tu	22	5	a	a	DT
cord-183197-dxmto1tu	22	6	broad	broad	JJ
cord-183197-dxmto1tu	22	7	band	band	NN
cord-183197-dxmto1tu	22	8	of	of	IN
cord-183197-dxmto1tu	22	9	related	related	JJ
cord-183197-dxmto1tu	22	10	antibiotics	antibiotic	NNS
cord-183197-dxmto1tu	22	11	have	have	VBP
cord-183197-dxmto1tu	22	12	been	be	VBN
cord-183197-dxmto1tu	22	13	approved	approve	VBN
cord-183197-dxmto1tu	22	14	by	by	IN
cord-183197-dxmto1tu	22	15	the	the	DT
cord-183197-dxmto1tu	22	16	FDA	FDA	NNP
cord-183197-dxmto1tu	22	17	4;7	4;7	CD
cord-183197-dxmto1tu	22	18	.	.	.
cord-183197-dxmto1tu	23	1	In	in	IN
cord-183197-dxmto1tu	23	2	this	this	DT
cord-183197-dxmto1tu	23	3	work	work	NN
cord-183197-dxmto1tu	23	4	,	,	,
cord-183197-dxmto1tu	23	5	we	-PRON-	PRP
cord-183197-dxmto1tu	23	6	quantify	quantify	VBP
cord-183197-dxmto1tu	23	7	the	the	DT
cord-183197-dxmto1tu	23	8	performance	performance	NN
cord-183197-dxmto1tu	23	9	of	of	IN
cord-183197-dxmto1tu	23	10	1	1	CD
cord-183197-dxmto1tu	23	11	To	to	TO
cord-183197-dxmto1tu	23	12	whom	whom	WP
cord-183197-dxmto1tu	23	13	correspondence	correspondence	NN
cord-183197-dxmto1tu	23	14	may	may	MD
cord-183197-dxmto1tu	23	15	be	be	VB
cord-183197-dxmto1tu	23	16	addressed	address	VBN
cord-183197-dxmto1tu	23	17	.	.	.
cord-183197-dxmto1tu	24	1	Email	email	NN
cord-183197-dxmto1tu	24	2	:	:	:
cord-183197-dxmto1tu	24	3	tomzhao@u.northwestern.edu	tomzhao@u.northwestern.edu	ADD
cord-183197-dxmto1tu	24	4	;	;	:
cord-183197-dxmto1tu	25	1	n-patankar@northwestern.edu	n-patankar@northwestern.edu	NNP
cord-183197-dxmto1tu	25	2	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	25	3	in	in	IN
cord-183197-dxmto1tu	25	4	inhibiting	inhibit	VBG
cord-183197-dxmto1tu	25	5	the	the	DT
cord-183197-dxmto1tu	25	6	binding	binding	NN
cord-183197-dxmto1tu	25	7	of	of	IN
cord-183197-dxmto1tu	25	8	the	the	DT
cord-183197-dxmto1tu	25	9	SARS	SARS	NNP
cord-183197-dxmto1tu	25	10	-	-	HYPH
cord-183197-dxmto1tu	25	11	CoV	CoV	NNP
cord-183197-dxmto1tu	25	12	2	2	CD
cord-183197-dxmto1tu	25	13	spike	spike	NN
cord-183197-dxmto1tu	25	14	protein	protein	NN
cord-183197-dxmto1tu	25	15	to	to	IN
cord-183197-dxmto1tu	25	16	ACE2	ACE2	NNP
cord-183197-dxmto1tu	25	17	.	.	.
cord-183197-dxmto1tu	26	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	26	2	is	be	VBZ
cord-183197-dxmto1tu	26	3	found	find	VBN
cord-183197-dxmto1tu	26	4	to	to	TO
cord-183197-dxmto1tu	26	5	bind	bind	VB
cord-183197-dxmto1tu	26	6	more	more	RBR
cord-183197-dxmto1tu	26	7	favorably	favorably	RB
cord-183197-dxmto1tu	26	8	to	to	IN
cord-183197-dxmto1tu	26	9	the	the	DT
cord-183197-dxmto1tu	26	10	receptor	receptor	NN
cord-183197-dxmto1tu	26	11	binding	bind	VBG
cord-183197-dxmto1tu	26	12	domain	domain	NN
cord-183197-dxmto1tu	26	13	(	(	-LRB-
cord-183197-dxmto1tu	26	14	RBD	RBD	NNP
cord-183197-dxmto1tu	26	15	)	)	-RRB-
cord-183197-dxmto1tu	26	16	of	of	IN
cord-183197-dxmto1tu	26	17	the	the	DT
cord-183197-dxmto1tu	26	18	spike	spike	NN
cord-183197-dxmto1tu	26	19	protein	protein	NN
cord-183197-dxmto1tu	26	20	compared	compare	VBN
cord-183197-dxmto1tu	26	21	to	to	IN
cord-183197-dxmto1tu	26	22	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	26	23	or	or	CC
cord-183197-dxmto1tu	26	24	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	26	25	,	,	,
cord-183197-dxmto1tu	26	26	which	which	WDT
cord-183197-dxmto1tu	26	27	was	be	VBD
cord-183197-dxmto1tu	26	28	included	include	VBN
cord-183197-dxmto1tu	26	29	in	in	IN
cord-183197-dxmto1tu	26	30	this	this	DT
cord-183197-dxmto1tu	26	31	study	study	NN
cord-183197-dxmto1tu	26	32	as	as	IN
cord-183197-dxmto1tu	26	33	a	a	DT
cord-183197-dxmto1tu	26	34	baseline	baseline	NN
cord-183197-dxmto1tu	26	35	.	.	.
cord-183197-dxmto1tu	27	1	The	the	DT
cord-183197-dxmto1tu	27	2	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	27	3	-	-	HYPH
cord-183197-dxmto1tu	27	4	RBD	RBD	NNP
cord-183197-dxmto1tu	27	5	complex	complex	NN
cord-183197-dxmto1tu	27	6	also	also	RB
cord-183197-dxmto1tu	27	7	displays	display	VBZ
cord-183197-dxmto1tu	27	8	lower	lower	RBR
cord-183197-dxmto1tu	27	9	binding	bind	VBG
cord-183197-dxmto1tu	27	10	efficiency	efficiency	NN
cord-183197-dxmto1tu	27	11	to	to	IN
cord-183197-dxmto1tu	27	12	the	the	DT
cord-183197-dxmto1tu	27	13	human	human	JJ
cord-183197-dxmto1tu	27	14	cell	cell	NN
cord-183197-dxmto1tu	27	15	receptor	receptor	NN
cord-183197-dxmto1tu	27	16	ACE2	ACE2	NNP
cord-183197-dxmto1tu	27	17	.	.	.
cord-183197-dxmto1tu	28	1	The	the	DT
cord-183197-dxmto1tu	28	2	SARS	SARS	NNP
cord-183197-dxmto1tu	28	3	-	-	HYPH
cord-183197-dxmto1tu	28	4	CoV	CoV	NNP
cord-183197-dxmto1tu	28	5	2	2	CD
cord-183197-dxmto1tu	28	6	RBD	RBD	NNP
cord-183197-dxmto1tu	28	7	,	,	,
cord-183197-dxmto1tu	28	8	ACE2	ACE2	NNP
cord-183197-dxmto1tu	28	9	,	,	,
cord-183197-dxmto1tu	28	10	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	28	11	,	,	,
cord-183197-dxmto1tu	28	12	and	and	CC
cord-183197-dxmto1tu	28	13	Chloroquine	chloroquine	JJ
cord-183197-dxmto1tu	28	14	molecular	molecular	JJ
cord-183197-dxmto1tu	28	15	structures	structure	NNS
cord-183197-dxmto1tu	28	16	were	be	VBD
cord-183197-dxmto1tu	28	17	obtained	obtain	VBN
cord-183197-dxmto1tu	28	18	from	from	IN
cord-183197-dxmto1tu	28	19	RCSB	RCSB	NNP
cord-183197-dxmto1tu	28	20	PDB	PDB	NNP
cord-183197-dxmto1tu	28	21	(	(	-LRB-
cord-183197-dxmto1tu	28	22	6M0J	6m0j	CD
cord-183197-dxmto1tu	28	23	,	,	,
cord-183197-dxmto1tu	28	24	2UXO	2uxo	CD
cord-183197-dxmto1tu	28	25	,	,	,
cord-183197-dxmto1tu	28	26	4V2O	4v2o	CD
cord-183197-dxmto1tu	28	27	,	,	,
cord-183197-dxmto1tu	28	28	2XRL	2xrl	CD
cord-183197-dxmto1tu	28	29	)	)	-RRB-
cord-183197-dxmto1tu	28	30	14;15;16;17	14;15;16;17	CD
cord-183197-dxmto1tu	28	31	.	.	.
cord-183197-dxmto1tu	29	1	Missing	miss	VBG
cord-183197-dxmto1tu	29	2	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	29	3	atoms	atom	NNS
cord-183197-dxmto1tu	29	4	were	be	VBD
cord-183197-dxmto1tu	29	5	appended	append	VBN
cord-183197-dxmto1tu	29	6	,	,	,
cord-183197-dxmto1tu	29	7	after	after	IN
cord-183197-dxmto1tu	29	8	which	which	WDT
cord-183197-dxmto1tu	29	9	structural	structural	JJ
cord-183197-dxmto1tu	29	10	preparation	preparation	NN
cord-183197-dxmto1tu	29	11	and	and	CC
cord-183197-dxmto1tu	29	12	molecular	molecular	JJ
cord-183197-dxmto1tu	29	13	docking	docking	NN
cord-183197-dxmto1tu	29	14	with	with	IN
cord-183197-dxmto1tu	29	15	full	full	JJ
cord-183197-dxmto1tu	29	16	ligand	ligand	NN
cord-183197-dxmto1tu	29	17	and	and	CC
cord-183197-dxmto1tu	29	18	protein	protein	NN
cord-183197-dxmto1tu	29	19	backbone	backbone	NN
cord-183197-dxmto1tu	29	20	flexibility	flexibility	NN
cord-183197-dxmto1tu	29	21	were	be	VBD
cord-183197-dxmto1tu	29	22	carried	carry	VBN
cord-183197-dxmto1tu	29	23	out	out	RP
cord-183197-dxmto1tu	29	24	using	use	VBG
cord-183197-dxmto1tu	29	25	the	the	DT
cord-183197-dxmto1tu	29	26	Rosetta	Rosetta	NNP
cord-183197-dxmto1tu	29	27	suite	suite	NN
cord-183197-dxmto1tu	29	28	18;19;20	18;19;20	CD
cord-183197-dxmto1tu	29	29	.	.	.
cord-183197-dxmto1tu	30	1	The	the	DT
cord-183197-dxmto1tu	30	2	resulting	result	VBG
cord-183197-dxmto1tu	30	3	complexes	complex	NNS
cord-183197-dxmto1tu	30	4	were	be	VBD
cord-183197-dxmto1tu	30	5	inspected	inspect	VBN
cord-183197-dxmto1tu	30	6	manually	manually	RB
cord-183197-dxmto1tu	30	7	,	,	,
cord-183197-dxmto1tu	30	8	after	after	IN
cord-183197-dxmto1tu	30	9	which	which	WDT
cord-183197-dxmto1tu	30	10	the	the	DT
cord-183197-dxmto1tu	30	11	binding	bind	VBG
cord-183197-dxmto1tu	30	12	affinities	affinity	NNS
cord-183197-dxmto1tu	30	13	of	of	IN
cord-183197-dxmto1tu	30	14	the	the	DT
cord-183197-dxmto1tu	30	15	best	well	RBS
cord-183197-dxmto1tu	30	16	-	-	HYPH
cord-183197-dxmto1tu	30	17	scoring	score	VBG
cord-183197-dxmto1tu	30	18	complexes	complex	NNS
cord-183197-dxmto1tu	30	19	were	be	VBD
cord-183197-dxmto1tu	30	20	gauged	gauge	VBN
cord-183197-dxmto1tu	30	21	us	-PRON-	PRP
cord-183197-dxmto1tu	30	22	-	-	HYPH
cord-183197-dxmto1tu	30	23	ing	ing	NNP
cord-183197-dxmto1tu	30	24	MM	MM	NNP
cord-183197-dxmto1tu	30	25	/	/	SYM
cord-183197-dxmto1tu	30	26	PBSA	PBSA	NNP
cord-183197-dxmto1tu	30	27	calculations	calculation	NNS
cord-183197-dxmto1tu	30	28	after	after	IN
cord-183197-dxmto1tu	30	29	100	100	CD
cord-183197-dxmto1tu	30	30	ns	ns	IN
cord-183197-dxmto1tu	30	31	equilibrium	equilibrium	NN
cord-183197-dxmto1tu	30	32	molecular	molecular	JJ
cord-183197-dxmto1tu	30	33	dynamics	dynamic	NNS
cord-183197-dxmto1tu	30	34	simulations	simulation	NNS
cord-183197-dxmto1tu	30	35	21;22;23	21;22;23	CD
cord-183197-dxmto1tu	30	36	.	.	.
cord-183197-dxmto1tu	31	1	The	the	DT
cord-183197-dxmto1tu	31	2	potentials	potential	NNS
cord-183197-dxmto1tu	31	3	of	of	IN
cord-183197-dxmto1tu	31	4	mean	mean	JJ
cord-183197-dxmto1tu	31	5	force	force	NNP
cord-183197-dxmto1tu	31	6	(	(	-LRB-
cord-183197-dxmto1tu	31	7	PMF	PMF	NNP
cord-183197-dxmto1tu	31	8	)	)	-RRB-
cord-183197-dxmto1tu	31	9	24	24	CD
cord-183197-dxmto1tu	31	10	along	along	IN
cord-183197-dxmto1tu	31	11	the	the	DT
cord-183197-dxmto1tu	31	12	dissociation	dissociation	NN
cord-183197-dxmto1tu	31	13	pathway	pathway	NN
cord-183197-dxmto1tu	31	14	of	of	IN
cord-183197-dxmto1tu	31	15	these	these	DT
cord-183197-dxmto1tu	31	16	RBD	RBD	NNP
cord-183197-dxmto1tu	31	17	complexes	complex	NNS
cord-183197-dxmto1tu	31	18	from	from	IN
cord-183197-dxmto1tu	31	19	ACE2	ACE2	NNP
cord-183197-dxmto1tu	31	20	were	be	VBD
cord-183197-dxmto1tu	31	21	found	find	VBN
cord-183197-dxmto1tu	31	22	in	in	IN
cord-183197-dxmto1tu	31	23	LAMMPS	LAMMPS	NNP
cord-183197-dxmto1tu	31	24	25	25	CD
cord-183197-dxmto1tu	31	25	using	use	VBG
cord-183197-dxmto1tu	31	26	steered	steer	VBN
cord-183197-dxmto1tu	31	27	molecular	molecular	JJ
cord-183197-dxmto1tu	31	28	dynamics	dynamic	NNS
cord-183197-dxmto1tu	31	29	after	after	IN
cord-183197-dxmto1tu	31	30	parameterization	parameterization	NN
cord-183197-dxmto1tu	31	31	with	with	IN
cord-183197-dxmto1tu	31	32	CHARMM	CHARMM	NNP
cord-183197-dxmto1tu	31	33	26	26	CD
cord-183197-dxmto1tu	31	34	.	.	.
cord-183197-dxmto1tu	32	1	Jarzynski	Jarzynski	NNP
cord-183197-dxmto1tu	32	2	's	's	POS
cord-183197-dxmto1tu	32	3	equality	equality	NN
cord-183197-dxmto1tu	32	4	was	be	VBD
cord-183197-dxmto1tu	32	5	employed	employ	VBN
cord-183197-dxmto1tu	32	6	to	to	TO
cord-183197-dxmto1tu	32	7	calculate	calculate	VB
cord-183197-dxmto1tu	32	8	the	the	DT
cord-183197-dxmto1tu	32	9	free	free	JJ
cord-183197-dxmto1tu	32	10	energy	energy	NN
cord-183197-dxmto1tu	32	11	profile	profile	NN
cord-183197-dxmto1tu	32	12	for	for	IN
cord-183197-dxmto1tu	32	13	each	each	DT
cord-183197-dxmto1tu	32	14	RBD	RBD	NNP
cord-183197-dxmto1tu	32	15	complex	complex	NN
cord-183197-dxmto1tu	32	16	from	from	IN
cord-183197-dxmto1tu	32	17	10	10	CD
cord-183197-dxmto1tu	32	18	statistically	statistically	RB
cord-183197-dxmto1tu	32	19	independent	independent	JJ
cord-183197-dxmto1tu	32	20	trajectories	trajectory	NNS
cord-183197-dxmto1tu	32	21	27	27	CD
cord-183197-dxmto1tu	32	22	.	.	.
cord-183197-dxmto1tu	33	1	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	33	2	exhibits	exhibit	VBZ
cord-183197-dxmto1tu	33	3	higher	high	JJR
cord-183197-dxmto1tu	33	4	binding	bind	VBG
cord-183197-dxmto1tu	33	5	affinity	affinity	NN
cord-183197-dxmto1tu	33	6	to	to	IN
cord-183197-dxmto1tu	33	7	the	the	DT
cord-183197-dxmto1tu	33	8	RBD	RBD	NNP
cord-183197-dxmto1tu	33	9	in	in	IN
cord-183197-dxmto1tu	33	10	both	both	CC
cord-183197-dxmto1tu	33	11	blind	blind	JJ
cord-183197-dxmto1tu	33	12	and	and	CC
cord-183197-dxmto1tu	33	13	site	site	NN
cord-183197-dxmto1tu	33	14	-	-	HYPH
cord-183197-dxmto1tu	33	15	specific	specific	JJ
cord-183197-dxmto1tu	33	16	docking	docking	NN
cord-183197-dxmto1tu	33	17	(	(	-LRB-
cord-183197-dxmto1tu	33	18	-9.40	-9.40	CD
cord-183197-dxmto1tu	33	19	kcal	kcal	NNP
cord-183197-dxmto1tu	33	20	/	/	SYM
cord-183197-dxmto1tu	33	21	mol	mol	NN
cord-183197-dxmto1tu	33	22	)	)	-RRB-
cord-183197-dxmto1tu	33	23	compared	compare	VBN
cord-183197-dxmto1tu	33	24	to	to	IN
cord-183197-dxmto1tu	33	25	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	33	26	(	(	-LRB-
cord-183197-dxmto1tu	33	27	-8.08	-8.08	CD
cord-183197-dxmto1tu	33	28	kcal	kcal	NNP
cord-183197-dxmto1tu	33	29	/	/	SYM
cord-183197-dxmto1tu	33	30	mol	mol	NN
cord-183197-dxmto1tu	33	31	)	)	-RRB-
cord-183197-dxmto1tu	33	32	or	or	CC
cord-183197-dxmto1tu	33	33	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	33	34	(	(	-LRB-
cord-183197-dxmto1tu	33	35	-6.63	-6.63	CD
cord-183197-dxmto1tu	33	36	vs	vs	IN
cord-183197-dxmto1tu	33	37	6.31	6.31	CD
cord-183197-dxmto1tu	33	38	kcal	kcal	NNP
cord-183197-dxmto1tu	33	39	/	/	SYM
cord-183197-dxmto1tu	33	40	mol	mol	NN
cord-183197-dxmto1tu	33	41	)	)	-RRB-
cord-183197-dxmto1tu	33	42	as	as	IN
cord-183197-dxmto1tu	33	43	delineated	delineate	VBN
cord-183197-dxmto1tu	33	44	in	in	IN
cord-183197-dxmto1tu	33	45	Table	Table	NNP
cord-183197-dxmto1tu	33	46	1	1	CD
cord-183197-dxmto1tu	33	47	.	.	.
cord-183197-dxmto1tu	34	1	The	the	DT
cord-183197-dxmto1tu	34	2	amino	amino	NN
cord-183197-dxmto1tu	34	3	acid	acid	NN
cord-183197-dxmto1tu	34	4	residues	residue	NNS
cord-183197-dxmto1tu	34	5	of	of	IN
cord-183197-dxmto1tu	34	6	the	the	DT
cord-183197-dxmto1tu	34	7	RBD	RBD	NNP
cord-183197-dxmto1tu	34	8	involved	involve	VBN
cord-183197-dxmto1tu	34	9	in	in	IN
cord-183197-dxmto1tu	34	10	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	34	11	bonding	bonding	NN
cord-183197-dxmto1tu	34	12	with	with	IN
cord-183197-dxmto1tu	34	13	the	the	DT
cord-183197-dxmto1tu	34	14	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	34	15	molecule	molecule	NN
cord-183197-dxmto1tu	34	16	are	be	VBP
cord-183197-dxmto1tu	34	17	Tyr	Tyr	NNP
cord-183197-dxmto1tu	34	18	449	449	CD
cord-183197-dxmto1tu	34	19	,	,	,
cord-183197-dxmto1tu	34	20	Asn	Asn	NNP
cord-183197-dxmto1tu	34	21	501	501	CD
cord-183197-dxmto1tu	34	22	,	,	,
cord-183197-dxmto1tu	34	23	Gly	Gly	NNP
cord-183197-dxmto1tu	34	24	496	496	CD
cord-183197-dxmto1tu	34	25	,	,	,
cord-183197-dxmto1tu	34	26	and	and	CC
cord-183197-dxmto1tu	34	27	Tyr	Tyr	NNP
cord-183197-dxmto1tu	34	28	505	505	CD
cord-183197-dxmto1tu	35	1	(	(	-LRB-
cord-183197-dxmto1tu	35	2	Fig	Fig	NNP
cord-183197-dxmto1tu	35	3	.	.	NNP
cord-183197-dxmto1tu	35	4	1	1	CD
cord-183197-dxmto1tu	35	5	)	)	-RRB-
cord-183197-dxmto1tu	35	6	,	,	,
cord-183197-dxmto1tu	35	7	which	which	WDT
cord-183197-dxmto1tu	35	8	have	have	VBP
cord-183197-dxmto1tu	35	9	been	be	VBN
cord-183197-dxmto1tu	35	10	shown	show	VBN
cord-183197-dxmto1tu	35	11	to	to	TO
cord-183197-dxmto1tu	35	12	be	be	VB
cord-183197-dxmto1tu	35	13	crucial	crucial	JJ
cord-183197-dxmto1tu	35	14	for	for	IN
cord-183197-dxmto1tu	35	15	the	the	DT
cord-183197-dxmto1tu	35	16	SARS	SARS	NNP
cord-183197-dxmto1tu	35	17	-	-	HYPH
cord-183197-dxmto1tu	35	18	CoV	CoV	NNP
cord-183197-dxmto1tu	35	19	2	2	CD
cord-183197-dxmto1tu	35	20	RBD	RBD	NNP
cord-183197-dxmto1tu	35	21	in	in	IN
cord-183197-dxmto1tu	35	22	binding	bind	VBG
cord-183197-dxmto1tu	35	23	to	to	IN
cord-183197-dxmto1tu	35	24	ACE2	ACE2	NNP
cord-183197-dxmto1tu	35	25	for	for	IN
cord-183197-dxmto1tu	35	26	cellular	cellular	JJ
cord-183197-dxmto1tu	35	27	access	access	NN
cord-183197-dxmto1tu	35	28	8	8	CD
cord-183197-dxmto1tu	35	29	.	.	.
cord-183197-dxmto1tu	36	1	These	these	DT
cord-183197-dxmto1tu	36	2	four	four	CD
cord-183197-dxmto1tu	36	3	residues	residue	NNS
cord-183197-dxmto1tu	36	4	comprise	comprise	VBP
cord-183197-dxmto1tu	36	5	major	major	JJ
cord-183197-dxmto1tu	36	6	hot	hot	JJ
cord-183197-dxmto1tu	36	7	spots	spot	NNS
cord-183197-dxmto1tu	36	8	that	that	WDT
cord-183197-dxmto1tu	36	9	form	form	VBP
cord-183197-dxmto1tu	36	10	persistent	persistent	JJ
cord-183197-dxmto1tu	36	11	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	36	12	bonds	bond	NNS
cord-183197-dxmto1tu	36	13	with	with	IN
cord-183197-dxmto1tu	36	14	ACE2	ACE2	NNP
cord-183197-dxmto1tu	36	15	.	.	.
cord-183197-dxmto1tu	37	1	Meanwhile	meanwhile	RB
cord-183197-dxmto1tu	37	2	,	,	,
cord-183197-dxmto1tu	37	3	the	the	DT
cord-183197-dxmto1tu	37	4	amino	amino	NN
cord-183197-dxmto1tu	37	5	acids	acid	NNS
cord-183197-dxmto1tu	37	6	of	of	IN
cord-183197-dxmto1tu	37	7	RBD	RBD	NNP
cord-183197-dxmto1tu	37	8	that	that	WDT
cord-183197-dxmto1tu	37	9	interact	interact	VBP
cord-183197-dxmto1tu	37	10	with	with	IN
cord-183197-dxmto1tu	37	11	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	37	12	in	in	IN
cord-183197-dxmto1tu	37	13	the	the	DT
cord-183197-dxmto1tu	37	14	site	site	NN
cord-183197-dxmto1tu	37	15	-	-	HYPH
cord-183197-dxmto1tu	37	16	specific	specific	JJ
cord-183197-dxmto1tu	37	17	configuration	configuration	NN
cord-183197-dxmto1tu	37	18	are	be	VBP
cord-183197-dxmto1tu	37	19	Lys	Lys	NNP
cord-183197-dxmto1tu	37	20	356	356	CD
cord-183197-dxmto1tu	37	21	,	,	,
cord-183197-dxmto1tu	37	22	Arg	Arg	NNP
cord-183197-dxmto1tu	37	23	454	454	CD
cord-183197-dxmto1tu	37	24	,	,	,
cord-183197-dxmto1tu	37	25	Arg	Arg	NNP
cord-183197-dxmto1tu	37	26	466	466	CD
cord-183197-dxmto1tu	37	27	and	and	CC
cord-183197-dxmto1tu	37	28	Arg	Arg	NNP
cord-183197-dxmto1tu	37	29	355	355	CD
cord-183197-dxmto1tu	37	30	,	,	,
cord-183197-dxmto1tu	37	31	of	of	IN
cord-183197-dxmto1tu	37	32	which	which	WDT
cord-183197-dxmto1tu	37	33	none	none	NN
cord-183197-dxmto1tu	37	34	are	be	VBP
cord-183197-dxmto1tu	37	35	involved	involve	VBN
cord-183197-dxmto1tu	37	36	in	in	IN
cord-183197-dxmto1tu	37	37	extended	extended	JJ
cord-183197-dxmto1tu	37	38	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	37	39	bonding	bonding	NN
cord-183197-dxmto1tu	37	40	with	with	IN
cord-183197-dxmto1tu	37	41	ACE2	ACE2	NNP
cord-183197-dxmto1tu	37	42	.	.	.
cord-183197-dxmto1tu	38	1	Tetracyline	Tetracyline	NNP
cord-183197-dxmto1tu	38	2	appears	appear	VBZ
cord-183197-dxmto1tu	38	3	to	to	TO
cord-183197-dxmto1tu	38	4	bind	bind	VB
cord-183197-dxmto1tu	38	5	preferably	preferably	RB
cord-183197-dxmto1tu	38	6	to	to	TO
cord-183197-dxmto1tu	38	7	polar	polar	JJ
cord-183197-dxmto1tu	38	8	or	or	CC
cord-183197-dxmto1tu	38	9	slightly	slightly	RB
cord-183197-dxmto1tu	38	10	lipophilic	lipophilic	JJ
cord-183197-dxmto1tu	38	11	RBD	rbd	NN
cord-183197-dxmto1tu	38	12	residues	residue	NNS
cord-183197-dxmto1tu	38	13	,	,	,
cord-183197-dxmto1tu	38	14	which	which	WDT
cord-183197-dxmto1tu	38	15	comprise	comprise	VBP
cord-183197-dxmto1tu	38	16	the	the	DT
cord-183197-dxmto1tu	38	17	majority	majority	NN
cord-183197-dxmto1tu	38	18	of	of	IN
cord-183197-dxmto1tu	38	19	amino	amino	JJ
cord-183197-dxmto1tu	38	20	acids	acid	NNS
cord-183197-dxmto1tu	38	21	that	that	WDT
cord-183197-dxmto1tu	38	22	form	form	VBP
cord-183197-dxmto1tu	38	23	persistent	persistent	JJ
cord-183197-dxmto1tu	38	24	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	38	25	bonds	bond	NNS
cord-183197-dxmto1tu	38	26	with	with	IN
cord-183197-dxmto1tu	38	27	ACE2	ACE2	NNP
cord-183197-dxmto1tu	38	28	8;9	8;9	CD
cord-183197-dxmto1tu	38	29	.	.	.
cord-183197-dxmto1tu	39	1	Other	other	JJ
cord-183197-dxmto1tu	39	2	tetracycline	tetracycline	NN
cord-183197-dxmto1tu	39	3	derivatives	derivative	NNS
cord-183197-dxmto1tu	39	4	as	as	IN
cord-183197-dxmto1tu	39	5	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	39	6	or	or	CC
cord-183197-dxmto1tu	39	7	Minocycline	Minocycline	NNP
cord-183197-dxmto1tu	39	8	are	be	VBP
cord-183197-dxmto1tu	39	9	known	know	VBN
cord-183197-dxmto1tu	39	10	to	to	TO
cord-183197-dxmto1tu	39	11	be	be	VB
cord-183197-dxmto1tu	39	12	more	more	RBR
cord-183197-dxmto1tu	39	13	lipophilic	lipophilic	JJ
cord-183197-dxmto1tu	39	14	3;4;9	3;4;9	NN
cord-183197-dxmto1tu	39	15	and	and	CC
cord-183197-dxmto1tu	39	16	may	may	MD
cord-183197-dxmto1tu	39	17	therefore	therefore	RB
cord-183197-dxmto1tu	39	18	prefer	prefer	VB
cord-183197-dxmto1tu	39	19	nonpolar	nonpolar	JJ
cord-183197-dxmto1tu	39	20	residues	residue	NNS
cord-183197-dxmto1tu	39	21	10	10	CD
cord-183197-dxmto1tu	39	22	that	that	WDT
cord-183197-dxmto1tu	39	23	are	be	VBP
cord-183197-dxmto1tu	39	24	often	often	RB
cord-183197-dxmto1tu	39	25	buried	bury	VBN
cord-183197-dxmto1tu	39	26	beneath	beneath	IN
cord-183197-dxmto1tu	39	27	the	the	DT
cord-183197-dxmto1tu	39	28	solvent	solvent	NN
cord-183197-dxmto1tu	39	29	accessible	accessible	JJ
cord-183197-dxmto1tu	39	30	surface	surface	NN
cord-183197-dxmto1tu	39	31	area	area	NN
cord-183197-dxmto1tu	39	32	of	of	IN
cord-183197-dxmto1tu	39	33	the	the	DT
cord-183197-dxmto1tu	39	34	spike	spike	NN
cord-183197-dxmto1tu	39	35	protein	protein	NN
cord-183197-dxmto1tu	39	36	.	.	.
cord-183197-dxmto1tu	40	1	Indeed	indeed	RB
cord-183197-dxmto1tu	40	2	,	,	,
cord-183197-dxmto1tu	40	3	the	the	DT
cord-183197-dxmto1tu	40	4	RBD	RBD	NNP
cord-183197-dxmto1tu	40	5	residues	residue	NNS
cord-183197-dxmto1tu	40	6	that	that	WDT
cord-183197-dxmto1tu	40	7	have	have	VBP
cord-183197-dxmto1tu	40	8	highest	high	JJS
cord-183197-dxmto1tu	40	9	binding	bind	VBG
cord-183197-dxmto1tu	40	10	affinity	affinity	NN
cord-183197-dxmto1tu	40	11	to	to	IN
cord-183197-dxmto1tu	40	12	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	40	13	are	be	VBP
cord-183197-dxmto1tu	40	14	Tyr	Tyr	NNP
cord-183197-dxmto1tu	40	15	449	449	CD
cord-183197-dxmto1tu	40	16	,	,	,
cord-183197-dxmto1tu	40	17	Gly	Gly	NNP
cord-183197-dxmto1tu	40	18	447	447	CD
cord-183197-dxmto1tu	40	19	,	,	,
cord-183197-dxmto1tu	40	20	Val	Val	NNP
cord-183197-dxmto1tu	40	21	445	445	CD
cord-183197-dxmto1tu	40	22	,	,	,
cord-183197-dxmto1tu	40	23	Gly	Gly	NNP
cord-183197-dxmto1tu	40	24	496	496	CD
cord-183197-dxmto1tu	40	25	,	,	,
cord-183197-dxmto1tu	40	26	of	of	IN
cord-183197-dxmto1tu	40	27	which	which	WDT
cord-183197-dxmto1tu	40	28	only	only	RB
cord-183197-dxmto1tu	40	29	two	two	CD
cord-183197-dxmto1tu	40	30	overlap	overlap	VBP
cord-183197-dxmto1tu	40	31	with	with	IN
cord-183197-dxmto1tu	40	32	RBD	rbd	NN
cord-183197-dxmto1tu	40	33	amino	amino	NN
cord-183197-dxmto1tu	40	34	acids	acid	NNS
cord-183197-dxmto1tu	40	35	that	that	WDT
cord-183197-dxmto1tu	40	36	engage	engage	VBP
cord-183197-dxmto1tu	40	37	in	in	IN
cord-183197-dxmto1tu	40	38	extended	extended	JJ
cord-183197-dxmto1tu	40	39	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	40	40	bonding	bonding	NN
cord-183197-dxmto1tu	40	41	with	with	IN
cord-183197-dxmto1tu	40	42	ACE2	ACE2	NNP
cord-183197-dxmto1tu	40	43	.	.	.
cord-183197-dxmto1tu	41	1	On	on	IN
cord-183197-dxmto1tu	41	2	the	the	DT
cord-183197-dxmto1tu	41	3	other	other	JJ
cord-183197-dxmto1tu	41	4	end	end	NN
cord-183197-dxmto1tu	41	5	of	of	IN
cord-183197-dxmto1tu	41	6	the	the	DT
cord-183197-dxmto1tu	41	7	spectrum	spectrum	NN
cord-183197-dxmto1tu	41	8	,	,	,
cord-183197-dxmto1tu	41	9	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	41	10	targets	target	VBZ
cord-183197-dxmto1tu	41	11	clusters	cluster	NNS
cord-183197-dxmto1tu	41	12	of	of	IN
cord-183197-dxmto1tu	41	13	charged	charge	VBN
cord-183197-dxmto1tu	41	14	residues	residue	NNS
cord-183197-dxmto1tu	41	15	on	on	IN
cord-183197-dxmto1tu	41	16	the	the	DT
cord-183197-dxmto1tu	41	17	RBD	RBD	NNP
cord-183197-dxmto1tu	41	18	that	that	WDT
cord-183197-dxmto1tu	41	19	do	do	VBP
cord-183197-dxmto1tu	41	20	not	not	RB
cord-183197-dxmto1tu	41	21	actively	actively	RB
cord-183197-dxmto1tu	41	22	participate	participate	VB
cord-183197-dxmto1tu	41	23	in	in	IN
cord-183197-dxmto1tu	41	24	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	41	25	bonding	bonding	NN
cord-183197-dxmto1tu	41	26	with	with	IN
cord-183197-dxmto1tu	41	27	the	the	DT
cord-183197-dxmto1tu	41	28	cell	cell	NN
cord-183197-dxmto1tu	41	29	receptor	receptor	NN
cord-183197-dxmto1tu	41	30	ACE2	ACE2	NNP
cord-183197-dxmto1tu	41	31	.	.	.
cord-183197-dxmto1tu	42	1	The	the	DT
cord-183197-dxmto1tu	42	2	binding	bind	VBG
cord-183197-dxmto1tu	42	3	efficiency	efficiency	NN
cord-183197-dxmto1tu	42	4	13	13	CD
cord-183197-dxmto1tu	43	1	(	(	-LRB-
cord-183197-dxmto1tu	43	2	magnitude	magnitude	NN
cord-183197-dxmto1tu	43	3	of	of	IN
cord-183197-dxmto1tu	43	4	binding	bind	VBG
cord-183197-dxmto1tu	43	5	energy	energy	NN
cord-183197-dxmto1tu	43	6	normalized	normalize	VBN
cord-183197-dxmto1tu	43	7	by	by	IN
cord-183197-dxmto1tu	43	8	contact	contact	NN
cord-183197-dxmto1tu	43	9	interface	interface	NN
cord-183197-dxmto1tu	43	10	area	area	NN
cord-183197-dxmto1tu	43	11	)	)	-RRB-
cord-183197-dxmto1tu	43	12	of	of	IN
cord-183197-dxmto1tu	43	13	the	the	DT
cord-183197-dxmto1tu	43	14	SARS	SARS	NNP
cord-183197-dxmto1tu	43	15	-	-	HYPH
cord-183197-dxmto1tu	43	16	CoV2	CoV2	NNP
cord-183197-dxmto1tu	43	17	RBD	RBD	NNP
cord-183197-dxmto1tu	43	18	-	-	HYPH
cord-183197-dxmto1tu	43	19	ACE2	ACE2	NNP
cord-183197-dxmto1tu	43	20	complex	complex	NN
cord-183197-dxmto1tu	43	21	was	be	VBD
cord-183197-dxmto1tu	43	22	found	find	VBN
cord-183197-dxmto1tu	43	23	to	to	TO
cord-183197-dxmto1tu	43	24	be	be	VB
cord-183197-dxmto1tu	43	25	7.58	7.58	CD
cord-183197-dxmto1tu	43	26	kcal/(mol·nm	kcal/(mol·nm	CD
cord-183197-dxmto1tu	43	27	2	2	CD
cord-183197-dxmto1tu	43	28	)	)	-RRB-
cord-183197-dxmto1tu	43	29	.	.	.
cord-183197-dxmto1tu	44	1	In	in	IN
cord-183197-dxmto1tu	44	2	the	the	DT
cord-183197-dxmto1tu	44	3	presence	presence	NN
cord-183197-dxmto1tu	44	4	of	of	IN
cord-183197-dxmto1tu	44	5	the	the	DT
cord-183197-dxmto1tu	44	6	protein	protein	NN
cord-183197-dxmto1tu	44	7	-	-	HYPH
cord-183197-dxmto1tu	44	8	ligand	ligand	NN
cord-183197-dxmto1tu	44	9	complex	complex	JJ
cord-183197-dxmto1tu	44	10	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	44	11	-	-	HYPH
cord-183197-dxmto1tu	44	12	RBD	RBD	NNP
cord-183197-dxmto1tu	44	13	,	,	,
cord-183197-dxmto1tu	44	14	the	the	DT
cord-183197-dxmto1tu	44	15	binding	bind	VBG
cord-183197-dxmto1tu	44	16	efficiency	efficiency	NN
cord-183197-dxmto1tu	44	17	with	with	IN
cord-183197-dxmto1tu	44	18	ACE2	ACE2	NNP
cord-183197-dxmto1tu	44	19	(	(	-LRB-
cord-183197-dxmto1tu	44	20	2.98	2.98	CD
cord-183197-dxmto1tu	44	21	kcal/(mol·nm	kcal/(mol·nm	CD
cord-183197-dxmto1tu	44	22	2	2	CD
cord-183197-dxmto1tu	44	23	)	)	-RRB-
cord-183197-dxmto1tu	44	24	)	)	-RRB-
cord-183197-dxmto1tu	44	25	is	be	VBZ
cord-183197-dxmto1tu	44	26	significantly	significantly	RB
cord-183197-dxmto1tu	44	27	lower	low	JJR
cord-183197-dxmto1tu	44	28	than	than	IN
cord-183197-dxmto1tu	44	29	that	that	DT
cord-183197-dxmto1tu	44	30	for	for	IN
cord-183197-dxmto1tu	44	31	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	44	32	-	-	HYPH
cord-183197-dxmto1tu	44	33	RBD	RBD	NNP
cord-183197-dxmto1tu	44	34	(	(	-LRB-
cord-183197-dxmto1tu	44	35	5.59	5.59	CD
cord-183197-dxmto1tu	44	36	kcal/(mol·nm	kcal/(mol·nm	CD
cord-183197-dxmto1tu	44	37	2	2	CD
cord-183197-dxmto1tu	44	38	)	)	-RRB-
cord-183197-dxmto1tu	44	39	)	)	-RRB-
cord-183197-dxmto1tu	44	40	and	and	CC
cord-183197-dxmto1tu	44	41	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	44	42	-	-	HYPH
cord-183197-dxmto1tu	44	43	RBD	RBD	NNP
cord-183197-dxmto1tu	44	44	(	(	-LRB-
cord-183197-dxmto1tu	44	45	5.16	5.16	CD
cord-183197-dxmto1tu	44	46	kcal/(mol·nm	kcal/(mol·nm	CD
cord-183197-dxmto1tu	44	47	2	2	CD
cord-183197-dxmto1tu	44	48	)	)	-RRB-
cord-183197-dxmto1tu	44	49	)	)	-RRB-
cord-183197-dxmto1tu	44	50	as	as	IN
cord-183197-dxmto1tu	44	51	displayed	display	VBN
cord-183197-dxmto1tu	44	52	in	in	IN
cord-183197-dxmto1tu	44	53	Table	Table	NNP
cord-183197-dxmto1tu	44	54	2	2	CD
cord-183197-dxmto1tu	44	55	.	.	.
cord-183197-dxmto1tu	45	1	A	a	DT
cord-183197-dxmto1tu	45	2	survey	survey	NN
cord-183197-dxmto1tu	45	3	of	of	IN
cord-183197-dxmto1tu	45	4	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	45	5	bonding	bonding	NN
cord-183197-dxmto1tu	45	6	lifetimes	lifetime	NNS
cord-183197-dxmto1tu	45	7	between	between	IN
cord-183197-dxmto1tu	45	8	the	the	DT
cord-183197-dxmto1tu	45	9	important	important	JJ
cord-183197-dxmto1tu	45	10	binding	bind	VBG
cord-183197-dxmto1tu	45	11	site	site	NN
cord-183197-dxmto1tu	45	12	residues	residue	NNS
cord-183197-dxmto1tu	45	13	in	in	IN
cord-183197-dxmto1tu	45	14	the	the	DT
cord-183197-dxmto1tu	45	15	RBD	RBD	NNP
cord-183197-dxmto1tu	45	16	with	with	IN
cord-183197-dxmto1tu	45	17	ACE2	ACE2	NNP
cord-183197-dxmto1tu	45	18	8	8	CD
cord-183197-dxmto1tu	45	19	shows	show	VBZ
cord-183197-dxmto1tu	45	20	that	that	IN
cord-183197-dxmto1tu	45	21	the	the	DT
cord-183197-dxmto1tu	45	22	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	45	23	inhibited	inhibit	VBN
cord-183197-dxmto1tu	45	24	RBD	RBD	NNP
cord-183197-dxmto1tu	45	25	exhibits	exhibit	VBZ
cord-183197-dxmto1tu	45	26	the	the	DT
cord-183197-dxmto1tu	45	27	least	least	JJS
cord-183197-dxmto1tu	45	28	hydrogen	hydrogen	NN
cord-183197-dxmto1tu	45	29	bonding	bonding	NN
cord-183197-dxmto1tu	45	30	activity	activity	NN
cord-183197-dxmto1tu	45	31	with	with	IN
cord-183197-dxmto1tu	45	32	ACE2	ACE2	NNP
cord-183197-dxmto1tu	45	33	(	(	-LRB-
cord-183197-dxmto1tu	45	34	Fig	Fig	NNP
cord-183197-dxmto1tu	45	35	.	.	.
cord-183197-dxmto1tu	45	36	 	 	_SP
cord-183197-dxmto1tu	45	37	2	2	CD
cord-183197-dxmto1tu	45	38	)	)	-RRB-
cord-183197-dxmto1tu	45	39	.	.	.
cord-183197-dxmto1tu	46	1	This	this	DT
cord-183197-dxmto1tu	46	2	suggests	suggest	VBZ
cord-183197-dxmto1tu	46	3	that	that	IN
cord-183197-dxmto1tu	46	4	not	not	RB
cord-183197-dxmto1tu	46	5	only	only	RB
cord-183197-dxmto1tu	46	6	does	do	VBZ
cord-183197-dxmto1tu	46	7	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	46	8	bind	bind	VB
cord-183197-dxmto1tu	46	9	more	more	RBR
cord-183197-dxmto1tu	46	10	favorably	favorably	RB
cord-183197-dxmto1tu	46	11	to	to	IN
cord-183197-dxmto1tu	46	12	the	the	DT
cord-183197-dxmto1tu	46	13	receptor	receptor	NN
cord-183197-dxmto1tu	46	14	binding	bind	VBG
cord-183197-dxmto1tu	46	15	domain	domain	NN
cord-183197-dxmto1tu	46	16	of	of	IN
cord-183197-dxmto1tu	46	17	the	the	DT
cord-183197-dxmto1tu	46	18	spike	spike	NN
cord-183197-dxmto1tu	46	19	protein	protein	NN
cord-183197-dxmto1tu	46	20	,	,	,
cord-183197-dxmto1tu	46	21	it	-PRON-	PRP
cord-183197-dxmto1tu	46	22	also	also	RB
cord-183197-dxmto1tu	46	23	inhibits	inhibit	VBZ
cord-183197-dxmto1tu	46	24	the	the	DT
cord-183197-dxmto1tu	46	25	binding	binding	NN
cord-183197-dxmto1tu	46	26	of	of	IN
cord-183197-dxmto1tu	46	27	the	the	DT
cord-183197-dxmto1tu	46	28	RBD	RBD	NNP
cord-183197-dxmto1tu	46	29	to	to	IN
cord-183197-dxmto1tu	46	30	ACE2	ACE2	NNP
cord-183197-dxmto1tu	46	31	to	to	IN
cord-183197-dxmto1tu	46	32	a	a	DT
cord-183197-dxmto1tu	46	33	greater	great	JJR
cord-183197-dxmto1tu	46	34	degree	degree	NN
cord-183197-dxmto1tu	46	35	.	.	.
cord-183197-dxmto1tu	47	1	To	to	TO
cord-183197-dxmto1tu	47	2	verify	verify	VB
cord-183197-dxmto1tu	47	3	this	this	DT
cord-183197-dxmto1tu	47	4	statement	statement	NN
cord-183197-dxmto1tu	47	5	,	,	,
cord-183197-dxmto1tu	47	6	steered	steer	VBD
cord-183197-dxmto1tu	47	7	molecular	molecular	JJ
cord-183197-dxmto1tu	47	8	dynamics	dynamic	NNS
cord-183197-dxmto1tu	47	9	simulations	simulation	NNS
cord-183197-dxmto1tu	47	10	were	be	VBD
cord-183197-dxmto1tu	47	11	carried	carry	VBN
cord-183197-dxmto1tu	47	12	out	out	RP
cord-183197-dxmto1tu	47	13	to	to	TO
cord-183197-dxmto1tu	47	14	find	find	VB
cord-183197-dxmto1tu	47	15	the	the	DT
cord-183197-dxmto1tu	47	16	potential	potential	NN
cord-183197-dxmto1tu	47	17	of	of	IN
cord-183197-dxmto1tu	47	18	mean	mean	JJ
cord-183197-dxmto1tu	47	19	force	force	NNP
cord-183197-dxmto1tu	47	20	(	(	-LRB-
cord-183197-dxmto1tu	47	21	PMF	PMF	NNP
cord-183197-dxmto1tu	47	22	)	)	-RRB-
cord-183197-dxmto1tu	47	23	along	along	IN
cord-183197-dxmto1tu	47	24	a	a	DT
cord-183197-dxmto1tu	47	25	singular	singular	JJ
cord-183197-dxmto1tu	47	26	dissociation	dissociation	NN
cord-183197-dxmto1tu	47	27	pathway	pathway	NN
cord-183197-dxmto1tu	47	28	for	for	IN
cord-183197-dxmto1tu	47	29	the	the	DT
cord-183197-dxmto1tu	47	30	inhibited	inhibited	JJ
cord-183197-dxmto1tu	47	31	and	and	CC
cord-183197-dxmto1tu	47	32	uninhibited	uninhibited	JJ
cord-183197-dxmto1tu	47	33	RBD	RBD	NNP
cord-183197-dxmto1tu	47	34	-	-	HYPH
cord-183197-dxmto1tu	47	35	ACE2	ACE2	NNP
cord-183197-dxmto1tu	47	36	complexes	complex	NNS
cord-183197-dxmto1tu	47	37	.	.	.
cord-183197-dxmto1tu	48	1	Figure	figure	NN
cord-183197-dxmto1tu	48	2	3	3	CD
cord-183197-dxmto1tu	48	3	shows	show	VBZ
cord-183197-dxmto1tu	48	4	that	that	IN
cord-183197-dxmto1tu	48	5	the	the	DT
cord-183197-dxmto1tu	48	6	PMF	PMF	NNP
cord-183197-dxmto1tu	48	7	for	for	IN
cord-183197-dxmto1tu	48	8	unbinding	unbind	VBG
cord-183197-dxmto1tu	48	9	of	of	IN
cord-183197-dxmto1tu	48	10	the	the	DT
cord-183197-dxmto1tu	48	11	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	48	12	-	-	HYPH
cord-183197-dxmto1tu	48	13	RBD	RBD	NNP
cord-183197-dxmto1tu	48	14	complex	complex	NN
cord-183197-dxmto1tu	48	15	from	from	IN
cord-183197-dxmto1tu	48	16	ACE2	ACE2	NNP
cord-183197-dxmto1tu	48	17	was	be	VBD
cord-183197-dxmto1tu	48	18	lowest	low	JJS
cord-183197-dxmto1tu	48	19	of	of	IN
cord-183197-dxmto1tu	48	20	the	the	DT
cord-183197-dxmto1tu	48	21	three	three	CD
cord-183197-dxmto1tu	48	22	structures	structure	NNS
cord-183197-dxmto1tu	48	23	tested	test	VBN
cord-183197-dxmto1tu	48	24	,	,	,
cord-183197-dxmto1tu	48	25	which	which	WDT
cord-183197-dxmto1tu	48	26	is	be	VBZ
cord-183197-dxmto1tu	48	27	in	in	IN
cord-183197-dxmto1tu	48	28	agreement	agreement	NN
cord-183197-dxmto1tu	48	29	with	with	IN
cord-183197-dxmto1tu	48	30	the	the	DT
cord-183197-dxmto1tu	48	31	binding	bind	VBG
cord-183197-dxmto1tu	48	32	efficiencies	efficiency	NNS
cord-183197-dxmto1tu	48	33	found	find	VBN
cord-183197-dxmto1tu	48	34	from	from	IN
cord-183197-dxmto1tu	48	35	equilibrium	equilibrium	NN
cord-183197-dxmto1tu	48	36	simulations	simulation	NNS
cord-183197-dxmto1tu	48	37	.	.	.
cord-183197-dxmto1tu	49	1	This	this	DT
cord-183197-dxmto1tu	49	2	disruption	disruption	NN
cord-183197-dxmto1tu	49	3	of	of	IN
cord-183197-dxmto1tu	49	4	the	the	DT
cord-183197-dxmto1tu	49	5	RBD	RBD	NNP
cord-183197-dxmto1tu	49	6	-	-	HYPH
cord-183197-dxmto1tu	49	7	ACE2	ACE2	NNP
cord-183197-dxmto1tu	49	8	interface	interface	NN
cord-183197-dxmto1tu	49	9	may	may	MD
cord-183197-dxmto1tu	49	10	therefore	therefore	RB
cord-183197-dxmto1tu	49	11	inhibit	inhibit	VB
cord-183197-dxmto1tu	49	12	the	the	DT
cord-183197-dxmto1tu	49	13	signaling	signal	VBG
cord-183197-dxmto1tu	49	14	cascade	cascade	NN
cord-183197-dxmto1tu	49	15	initiated	initiate	VBN
cord-183197-dxmto1tu	49	16	during	during	IN
cord-183197-dxmto1tu	49	17	binding	binding	NN
cord-183197-dxmto1tu	49	18	of	of	IN
cord-183197-dxmto1tu	49	19	the	the	DT
cord-183197-dxmto1tu	49	20	viral	viral	JJ
cord-183197-dxmto1tu	49	21	spike	spike	NN
cord-183197-dxmto1tu	49	22	protein	protein	NN
cord-183197-dxmto1tu	49	23	.	.	.
cord-183197-dxmto1tu	50	1	Binding	bind	VBG
cord-183197-dxmto1tu	50	2	efficiency	efficiency	NN
cord-183197-dxmto1tu	50	3	to	to	IN
cord-183197-dxmto1tu	50	4	ACE2	ACE2	NNP
cord-183197-dxmto1tu	51	1	(	(	-LRB-
cord-183197-dxmto1tu	51	2	kcal/(mol·nm	kcal/(mol·nm	CD
cord-183197-dxmto1tu	51	3	2	2	CD
cord-183197-dxmto1tu	51	4	)	)	-RRB-
cord-183197-dxmto1tu	51	5	)	)	-RRB-
cord-183197-dxmto1tu	52	1	RBD	RBD	NNP
cord-183197-dxmto1tu	52	2	7.58	7.58	CD
cord-183197-dxmto1tu	52	3	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	52	4	-	-	HYPH
cord-183197-dxmto1tu	52	5	RBD	RBD	NNP
cord-183197-dxmto1tu	52	6	5.59	5.59	CD
cord-183197-dxmto1tu	52	7	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	52	8	-	-	HYPH
cord-183197-dxmto1tu	52	9	RBD	RBD	NNP
cord-183197-dxmto1tu	52	10	5.16	5.16	CD
cord-183197-dxmto1tu	52	11	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	52	12	-	-	HYPH
cord-183197-dxmto1tu	52	13	RBD	RBD	NNP
cord-183197-dxmto1tu	52	14	2.98	2.98	CD
cord-183197-dxmto1tu	52	15	Table	table	NN
cord-183197-dxmto1tu	52	16	2	2	CD
cord-183197-dxmto1tu	53	1	:	:	:
cord-183197-dxmto1tu	53	2	The	the	DT
cord-183197-dxmto1tu	53	3	binding	bind	VBG
cord-183197-dxmto1tu	53	4	efficiency	efficiency	NN
cord-183197-dxmto1tu	53	5	13	13	CD
cord-183197-dxmto1tu	53	6	(	(	-LRB-
cord-183197-dxmto1tu	53	7	magnitude	magnitude	NN
cord-183197-dxmto1tu	53	8	of	of	IN
cord-183197-dxmto1tu	53	9	binding	bind	VBG
cord-183197-dxmto1tu	53	10	energy	energy	NN
cord-183197-dxmto1tu	53	11	normalized	normalize	VBN
cord-183197-dxmto1tu	53	12	by	by	IN
cord-183197-dxmto1tu	53	13	contact	contact	NN
cord-183197-dxmto1tu	53	14	interface	interface	NN
cord-183197-dxmto1tu	53	15	area	area	NN
cord-183197-dxmto1tu	53	16	)	)	-RRB-
cord-183197-dxmto1tu	53	17	of	of	IN
cord-183197-dxmto1tu	53	18	the	the	DT
cord-183197-dxmto1tu	53	19	spike	spike	NN
cord-183197-dxmto1tu	53	20	protein	protein	NN
cord-183197-dxmto1tu	53	21	RBD	RBD	NNP
cord-183197-dxmto1tu	53	22	as	as	RB
cord-183197-dxmto1tu	53	23	well	well	RB
cord-183197-dxmto1tu	53	24	as	as	IN
cord-183197-dxmto1tu	53	25	the	the	DT
cord-183197-dxmto1tu	53	26	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	53	27	-	-	HYPH
cord-183197-dxmto1tu	53	28	RBD	RBD	NNP
cord-183197-dxmto1tu	53	29	,	,	,
cord-183197-dxmto1tu	53	30	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	53	31	-	-	HYPH
cord-183197-dxmto1tu	53	32	RBD	RBD	NNP
cord-183197-dxmto1tu	53	33	and	and	CC
cord-183197-dxmto1tu	53	34	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	53	35	-	-	HYPH
cord-183197-dxmto1tu	53	36	RBD	RBD	NNP
cord-183197-dxmto1tu	53	37	complexes	complex	NNS
cord-183197-dxmto1tu	53	38	to	to	IN
cord-183197-dxmto1tu	53	39	the	the	DT
cord-183197-dxmto1tu	53	40	human	human	JJ
cord-183197-dxmto1tu	53	41	cell	cell	NN
cord-183197-dxmto1tu	53	42	receptor	receptor	NN
cord-183197-dxmto1tu	53	43	ACE2	ACE2	NNP
cord-183197-dxmto1tu	53	44	.	.	.
cord-183197-dxmto1tu	54	1	Binding	bind	VBG
cord-183197-dxmto1tu	54	2	efficiency	efficiency	NN
cord-183197-dxmto1tu	54	3	is	be	VBZ
cord-183197-dxmto1tu	54	4	lowest	low	JJS
cord-183197-dxmto1tu	54	5	for	for	IN
cord-183197-dxmto1tu	54	6	the	the	DT
cord-183197-dxmto1tu	54	7	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	54	8	-	-	HYPH
cord-183197-dxmto1tu	54	9	RBD	RBD	NNP
cord-183197-dxmto1tu	54	10	complex	complex	NN
cord-183197-dxmto1tu	54	11	,	,	,
cord-183197-dxmto1tu	54	12	indicating	indicate	VBG
cord-183197-dxmto1tu	54	13	that	that	IN
cord-183197-dxmto1tu	54	14	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	54	15	is	be	VBZ
cord-183197-dxmto1tu	54	16	a	a	DT
cord-183197-dxmto1tu	54	17	more	more	RBR
cord-183197-dxmto1tu	54	18	effective	effective	JJ
cord-183197-dxmto1tu	54	19	inhibitor	inhibitor	NN
cord-183197-dxmto1tu	54	20	.	.	.
cord-183197-dxmto1tu	54	21	 	 	_SP
cord-183197-dxmto1tu	55	1	The	the	DT
cord-183197-dxmto1tu	55	2	tetracycline	tetracycline	JJ
cord-183197-dxmto1tu	55	3	class	class	NN
cord-183197-dxmto1tu	55	4	of	of	IN
cord-183197-dxmto1tu	55	5	antibiotics	antibiotic	NNS
cord-183197-dxmto1tu	55	6	,	,	,
cord-183197-dxmto1tu	55	7	including	include	VBG
cord-183197-dxmto1tu	55	8	Tetracycline	Tetracycline	NNP
cord-183197-dxmto1tu	55	9	,	,	,
cord-183197-dxmto1tu	55	10	Oxytetracycline	Oxytetracycline	NNP
cord-183197-dxmto1tu	55	11	,	,	,
cord-183197-dxmto1tu	55	12	and	and	CC
cord-183197-dxmto1tu	55	13	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	55	14	may	may	MD
cord-183197-dxmto1tu	55	15	be	be	VB
cord-183197-dxmto1tu	55	16	helpful	helpful	JJ
cord-183197-dxmto1tu	55	17	in	in	IN
cord-183197-dxmto1tu	55	18	the	the	DT
cord-183197-dxmto1tu	55	19	fight	fight	NN
cord-183197-dxmto1tu	55	20	against	against	IN
cord-183197-dxmto1tu	55	21	the	the	DT
cord-183197-dxmto1tu	55	22	coronavirus	coronavirus	NN
cord-183197-dxmto1tu	55	23	SARS	SARS	NNP
cord-183197-dxmto1tu	55	24	-	-	HYPH
cord-183197-dxmto1tu	55	25	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	55	26	,	,	,
cord-183197-dxmto1tu	55	27	due	due	IN
cord-183197-dxmto1tu	55	28	to	to	IN
cord-183197-dxmto1tu	55	29	its	-PRON-	PRP$
cord-183197-dxmto1tu	55	30	preferential	preferential	JJ
cord-183197-dxmto1tu	55	31	association	association	NN
cord-183197-dxmto1tu	55	32	with	with	IN
cord-183197-dxmto1tu	55	33	the	the	DT
cord-183197-dxmto1tu	55	34	important	important	JJ
cord-183197-dxmto1tu	55	35	residues	residue	NNS
cord-183197-dxmto1tu	55	36	in	in	IN
cord-183197-dxmto1tu	55	37	the	the	DT
cord-183197-dxmto1tu	55	38	viral	viral	JJ
cord-183197-dxmto1tu	55	39	receptor	receptor	NN
cord-183197-dxmto1tu	55	40	binding	bind	VBG
cord-183197-dxmto1tu	55	41	domain	domain	NN
cord-183197-dxmto1tu	55	42	and	and	CC
cord-183197-dxmto1tu	55	43	the	the	DT
cord-183197-dxmto1tu	55	44	resulting	result	VBG
cord-183197-dxmto1tu	55	45	strong	strong	JJ
cord-183197-dxmto1tu	55	46	inhibition	inhibition	NN
cord-183197-dxmto1tu	55	47	of	of	IN
cord-183197-dxmto1tu	55	48	the	the	DT
cord-183197-dxmto1tu	55	49	RBD	RBD	NNP
cord-183197-dxmto1tu	55	50	-	-	HYPH
cord-183197-dxmto1tu	55	51	ACE2	ACE2	NNP
cord-183197-dxmto1tu	55	52	complex	complex	NN
cord-183197-dxmto1tu	55	53	.	.	.
cord-183197-dxmto1tu	56	1	Further	further	JJ
cord-183197-dxmto1tu	56	2	experimental	experimental	JJ
cord-183197-dxmto1tu	56	3	studies	study	NNS
cord-183197-dxmto1tu	56	4	are	be	VBP
cord-183197-dxmto1tu	56	5	recommended	recommend	VBN
cord-183197-dxmto1tu	56	6	to	to	TO
cord-183197-dxmto1tu	56	7	validate	validate	VB
cord-183197-dxmto1tu	56	8	how	how	WRB
cord-183197-dxmto1tu	56	9	this	this	DT
cord-183197-dxmto1tu	56	10	reduction	reduction	NN
cord-183197-dxmto1tu	56	11	of	of	IN
cord-183197-dxmto1tu	56	12	cellular	cellular	JJ
cord-183197-dxmto1tu	56	13	infection	infection	NN
cord-183197-dxmto1tu	56	14	complements	complement	VBZ
cord-183197-dxmto1tu	56	15	or	or	CC
cord-183197-dxmto1tu	56	16	enhances	enhance	VBZ
cord-183197-dxmto1tu	56	17	the	the	DT
cord-183197-dxmto1tu	56	18	anti	anti	JJ
cord-183197-dxmto1tu	56	19	-	-	JJ
cord-183197-dxmto1tu	56	20	inflammatory	inflammatory	JJ
cord-183197-dxmto1tu	56	21	and	and	CC
cord-183197-dxmto1tu	56	22	anti	anti	JJ
cord-183197-dxmto1tu	56	23	-	-	JJ
cord-183197-dxmto1tu	56	24	viral	viral	JJ
cord-183197-dxmto1tu	56	25	properties	property	NNS
cord-183197-dxmto1tu	56	26	of	of	IN
cord-183197-dxmto1tu	56	27	tetracyclines	tetracycline	NNS
cord-183197-dxmto1tu	56	28	in	in	IN
cord-183197-dxmto1tu	56	29	their	-PRON-	PRP$
cord-183197-dxmto1tu	56	30	role	role	NN
cord-183197-dxmto1tu	56	31	as	as	IN
cord-183197-dxmto1tu	56	32	treatment	treatment	NN
cord-183197-dxmto1tu	56	33	for	for	IN
cord-183197-dxmto1tu	56	34	SARS	SARS	NNP
cord-183197-dxmto1tu	56	35	-	-	HYPH
cord-183197-dxmto1tu	56	36	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	56	37	.	.	.
cord-183197-dxmto1tu	57	1	Author	author	NN
cord-183197-dxmto1tu	57	2	contributions	contribution	NNS
cord-183197-dxmto1tu	58	1	T.Y.Z	T.Y.Z	NNP
cord-183197-dxmto1tu	58	2	conceived	conceive	VBD
cord-183197-dxmto1tu	58	3	and	and	CC
cord-183197-dxmto1tu	58	4	planned	plan	VBD
cord-183197-dxmto1tu	58	5	the	the	DT
cord-183197-dxmto1tu	58	6	research	research	NN
cord-183197-dxmto1tu	58	7	,	,	,
cord-183197-dxmto1tu	58	8	as	as	RB
cord-183197-dxmto1tu	58	9	well	well	RB
cord-183197-dxmto1tu	58	10	as	as	IN
cord-183197-dxmto1tu	58	11	performed	perform	VBN
cord-183197-dxmto1tu	58	12	calculations	calculation	NNS
cord-183197-dxmto1tu	58	13	.	.	.
cord-183197-dxmto1tu	59	1	N.A.P.	N.A.P.	NNP
cord-183197-dxmto1tu	59	2	and	and	CC
cord-183197-dxmto1tu	59	3	T.Y.Z.	T.Y.Z.	NNP
cord-183197-dxmto1tu	59	4	performed	perform	VBD
cord-183197-dxmto1tu	59	5	analysis	analysis	NN
cord-183197-dxmto1tu	59	6	and	and	CC
cord-183197-dxmto1tu	59	7	wrote	write	VBD
cord-183197-dxmto1tu	59	8	the	the	DT
cord-183197-dxmto1tu	59	9	manuscript	manuscript	NN
cord-183197-dxmto1tu	59	10	.	.	.
cord-183197-dxmto1tu	60	1	Silico	Silico	NNP
cord-183197-dxmto1tu	60	2	Identification	identification	NN
cord-183197-dxmto1tu	60	3	of	of	IN
cord-183197-dxmto1tu	60	4	Potent	Potent	NNP
cord-183197-dxmto1tu	60	5	Inhibitors	Inhibitors	NNPS
cord-183197-dxmto1tu	60	6	of	of	IN
cord-183197-dxmto1tu	60	7	COVID-19	COVID-19	NNP
cord-183197-dxmto1tu	60	8	Main	Main	NNP
cord-183197-dxmto1tu	60	9	Protease	Protease	NNP
cord-183197-dxmto1tu	60	10	(	(	-LRB-
cord-183197-dxmto1tu	60	11	Mpro	Mpro	NNP
cord-183197-dxmto1tu	60	12	)	)	-RRB-
cord-183197-dxmto1tu	60	13	and	and	CC
cord-183197-dxmto1tu	61	1	Angiotensin	angiotensin	NN
cord-183197-dxmto1tu	61	2	Converting	Converting	NNP
cord-183197-dxmto1tu	61	3	Enzyme	Enzyme	NNP
cord-183197-dxmto1tu	61	4	2	2	CD
cord-183197-dxmto1tu	61	5	(	(	-LRB-
cord-183197-dxmto1tu	61	6	ACE2	ACE2	NNP
cord-183197-dxmto1tu	61	7	)	)	-RRB-
cord-183197-dxmto1tu	61	8	from	from	IN
cord-183197-dxmto1tu	61	9	Natural	natural	JJ
cord-183197-dxmto1tu	61	10	Products	Products	NNPS
cord-183197-dxmto1tu	61	11	:	:	:
cord-183197-dxmto1tu	61	12	Quercetin	Quercetin	NNS
cord-183197-dxmto1tu	61	13	,	,	,
cord-183197-dxmto1tu	61	14	Hispidulin	Hispidulin	NNP
cord-183197-dxmto1tu	61	15	,	,	,
cord-183197-dxmto1tu	61	16	and	and	CC
cord-183197-dxmto1tu	61	17	Cirsimaritin	Cirsimaritin	NNP
cord-183197-dxmto1tu	61	18	Exhibited	exhibit	VBD
cord-183197-dxmto1tu	61	19	Better	Better	NNP
cord-183197-dxmto1tu	61	20	Potential	potential	JJ
cord-183197-dxmto1tu	61	21	Inhibition	Inhibition	NNP
cord-183197-dxmto1tu	61	22	than	than	IN
cord-183197-dxmto1tu	61	23	Hydroxy	Hydroxy	NNP
cord-183197-dxmto1tu	61	24	-	-	HYPH
cord-183197-dxmto1tu	61	25	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	61	26	Against	Against	NNP
cord-183197-dxmto1tu	61	27	COVID-19	COVID-19	NNP
cord-183197-dxmto1tu	61	28	Main	Main	NNP
cord-183197-dxmto1tu	61	29	Protease	Protease	NNP
cord-183197-dxmto1tu	61	30	Active	Active	NNP
cord-183197-dxmto1tu	61	31	Site	Site	NNP
cord-183197-dxmto1tu	61	32	and	and	CC
cord-183197-dxmto1tu	61	33	ACE2	ACE2	NNP
cord-183197-dxmto1tu	61	34	Docking	Docking	NNP
cord-183197-dxmto1tu	61	35	study	study	NN
cord-183197-dxmto1tu	61	36	of	of	IN
cord-183197-dxmto1tu	61	37	chloroquine	chloroquine	NNP
cord-183197-dxmto1tu	61	38	and	and	CC
cord-183197-dxmto1tu	61	39	hydroxychloroquine	hydroxychloroquine	NN
cord-183197-dxmto1tu	61	40	interaction	interaction	NN
cord-183197-dxmto1tu	61	41	with	with	IN
cord-183197-dxmto1tu	61	42	RNA	RNA	NNP
cord-183197-dxmto1tu	61	43	binding	binding	NN
cord-183197-dxmto1tu	61	44	domain	domain	NN
cord-183197-dxmto1tu	61	45	of	of	IN
cord-183197-dxmto1tu	61	46	nucleocapsid	nucleocapsid	NNP
cord-183197-dxmto1tu	61	47	phospho	phospho	NN
cord-183197-dxmto1tu	61	48	-	-	HYPH
cord-183197-dxmto1tu	61	49	protein	protein	NN
cord-183197-dxmto1tu	61	50	-an	-an	NNS
cord-183197-dxmto1tu	61	51	in	in	IN
cord-183197-dxmto1tu	61	52	silico	silico	NN
cord-183197-dxmto1tu	61	53	insight	insight	NN
cord-183197-dxmto1tu	61	54	into	into	IN
cord-183197-dxmto1tu	61	55	the	the	DT
cord-183197-dxmto1tu	61	56	comparative	comparative	JJ
cord-183197-dxmto1tu	61	57	efficacy	efficacy	NN
cord-183197-dxmto1tu	61	58	of	of	IN
cord-183197-dxmto1tu	61	59	repurposing	repurpose	VBG
cord-183197-dxmto1tu	61	60	antiviral	antiviral	JJ
cord-183197-dxmto1tu	61	61	drugs	drug	NNS
cord-183197-dxmto1tu	61	62	Therapeutic	therapeutic	JJ
cord-183197-dxmto1tu	61	63	Potential	Potential	NNP
cord-183197-dxmto1tu	61	64	for	for	IN
cord-183197-dxmto1tu	61	65	Tetracyclines	Tetracyclines	NNPS
cord-183197-dxmto1tu	61	66	in	in	IN
cord-183197-dxmto1tu	61	67	the	the	DT
cord-183197-dxmto1tu	61	68	Treatment	Treatment	NNP
cord-183197-dxmto1tu	61	69	of	of	IN
cord-183197-dxmto1tu	61	70	COVID-19	COVID-19	NNP
cord-183197-dxmto1tu	61	71	A	A	NNP
cord-183197-dxmto1tu	61	72	Proposed	propose	VBN
cord-183197-dxmto1tu	61	73	Randomized	Randomized	NNP
cord-183197-dxmto1tu	61	74	,	,	,
cord-183197-dxmto1tu	61	75	Double	Double	NNP
cord-183197-dxmto1tu	61	76	Blind	Blind	NNP
cord-183197-dxmto1tu	61	77	,	,	,
cord-183197-dxmto1tu	61	78	Placebo	Placebo	NNP
cord-183197-dxmto1tu	61	79	Controlled	Controlled	NNP
cord-183197-dxmto1tu	61	80	Study	Study	NNP
cord-183197-dxmto1tu	61	81	Evaluating	evaluate	VBG
cord-183197-dxmto1tu	61	82	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	61	83	for	for	IN
cord-183197-dxmto1tu	61	84	the	the	DT
cord-183197-dxmto1tu	61	85	Prevention	Prevention	NNP
cord-183197-dxmto1tu	61	86	of	of	IN
cord-183197-dxmto1tu	61	87	COVID-19	COVID-19	NNP
cord-183197-dxmto1tu	61	88	Infection	Infection	NNP
cord-183197-dxmto1tu	61	89	and	and	CC
cord-183197-dxmto1tu	61	90	Disease	Disease	NNP
cord-183197-dxmto1tu	62	1	In	in	IN
cord-183197-dxmto1tu	62	2	Healthcare	Healthcare	NNP
cord-183197-dxmto1tu	62	3	Workers	Workers	NNPS
cord-183197-dxmto1tu	62	4	with	with	IN
cord-183197-dxmto1tu	62	5	Ongoing	Ongoing	NNP
cord-183197-dxmto1tu	62	6	High	high	JJ
cord-183197-dxmto1tu	62	7	Risk	Risk	NNP
cord-183197-dxmto1tu	62	8	Exposure	Exposure	NNP
cord-183197-dxmto1tu	62	9	to	to	TO
cord-183197-dxmto1tu	62	10	COVID-19	covid-19	VB
cord-183197-dxmto1tu	62	11	Prophylaxis	Prophylaxis	NNP
cord-183197-dxmto1tu	62	12	with	with	IN
cord-183197-dxmto1tu	62	13	tetracyclines	tetracyclines	NNPS
cord-183197-dxmto1tu	62	14	in	in	IN
cord-183197-dxmto1tu	62	15	ards	ard	NNS
cord-183197-dxmto1tu	62	16	:	:	:
cord-183197-dxmto1tu	62	17	Potential	potential	JJ
cord-183197-dxmto1tu	62	18	therapy	therapy	NN
cord-183197-dxmto1tu	62	19	for	for	IN
cord-183197-dxmto1tu	62	20	covid-19-induced	covid-19-induced	NNP
cord-183197-dxmto1tu	62	21	ards	ard	NNS
cord-183197-dxmto1tu	62	22	?	?	.
cord-183197-dxmto1tu	63	1	medRxiv	medRxiv	NNS
cord-183197-dxmto1tu	63	2	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	63	3	as	as	IN
cord-183197-dxmto1tu	63	4	a	a	DT
cord-183197-dxmto1tu	63	5	potential	potential	JJ
cord-183197-dxmto1tu	63	6	partner	partner	NN
cord-183197-dxmto1tu	63	7	of	of	IN
cord-183197-dxmto1tu	63	8	covid-19	covid-19	NNP
cord-183197-dxmto1tu	63	9	therapies	therapy	NNS
cord-183197-dxmto1tu	63	10	FDA	FDA	NNP
cord-183197-dxmto1tu	63	11	approved	approve	VBD
cord-183197-dxmto1tu	63	12	antibacterial	antibacterial	JJ
cord-183197-dxmto1tu	63	13	drugs	drug	NNS
cord-183197-dxmto1tu	63	14	Structural	structural	JJ
cord-183197-dxmto1tu	63	15	and	and	CC
cord-183197-dxmto1tu	63	16	simulation	simulation	NN
cord-183197-dxmto1tu	63	17	analysis	analysis	NN
cord-183197-dxmto1tu	63	18	of	of	IN
cord-183197-dxmto1tu	63	19	hotspot	hotspot	NN
cord-183197-dxmto1tu	63	20	residues	residue	NNS
cord-183197-dxmto1tu	63	21	interactions	interaction	NNS
cord-183197-dxmto1tu	63	22	of	of	IN
cord-183197-dxmto1tu	63	23	SARS	SARS	NNP
cord-183197-dxmto1tu	63	24	-	-	HYPH
cord-183197-dxmto1tu	63	25	CoV	CoV	NNP
cord-183197-dxmto1tu	63	26	2	2	CD
cord-183197-dxmto1tu	63	27	with	with	IN
cord-183197-dxmto1tu	63	28	human	human	JJ
cord-183197-dxmto1tu	63	29	ACE2	ACE2	NNP
cord-183197-dxmto1tu	63	30	receptor	receptor	NN
cord-183197-dxmto1tu	63	31	Heuristic	heuristic	JJ
cord-183197-dxmto1tu	63	32	molecular	molecular	JJ
cord-183197-dxmto1tu	63	33	lipophilicity	lipophilicity	NN
cord-183197-dxmto1tu	63	34	potential	potential	NN
cord-183197-dxmto1tu	63	35	(	(	-LRB-
cord-183197-dxmto1tu	63	36	HMLP	HMLP	NNP
cord-183197-dxmto1tu	63	37	)	)	-RRB-
cord-183197-dxmto1tu	63	38	:	:	:
cord-183197-dxmto1tu	64	1	Lipophilicity	lipophilicity	NN
cord-183197-dxmto1tu	64	2	and	and	CC
cord-183197-dxmto1tu	64	3	hydrophilicity	hydrophilicity	NN
cord-183197-dxmto1tu	64	4	of	of	IN
cord-183197-dxmto1tu	64	5	amino	amino	NN
cord-183197-dxmto1tu	64	6	acid	acid	NN
cord-183197-dxmto1tu	64	7	side	side	NN
cord-183197-dxmto1tu	64	8	chains	chain	NNS
cord-183197-dxmto1tu	65	1	The	the	DT
cord-183197-dxmto1tu	65	2	Anti	Anti	NNP
cord-183197-dxmto1tu	65	3	-	-	NNP
cord-183197-dxmto1tu	65	4	Amyloidogenic	Amyloidogenic	NNP
cord-183197-dxmto1tu	65	5	Action	Action	NNP
cord-183197-dxmto1tu	65	6	of	of	IN
cord-183197-dxmto1tu	65	7	Doxycycline	Doxycycline	NNP
cord-183197-dxmto1tu	65	8	:	:	:
cord-183197-dxmto1tu	66	1	A	a	DT
cord-183197-dxmto1tu	66	2	Molecular	Molecular	NNP
cord-183197-dxmto1tu	66	3	Dynamics	Dynamics	NNPS
cord-183197-dxmto1tu	66	4	Study	Study	NNP
cord-183197-dxmto1tu	66	5	on	on	IN
cord-183197-dxmto1tu	66	6	the	the	DT
cord-183197-dxmto1tu	66	7	Interaction	Interaction	NNP
cord-183197-dxmto1tu	66	8	with	with	IN
cord-183197-dxmto1tu	66	9	AB42	AB42	NNP
cord-183197-dxmto1tu	66	10	Screening	Screening	NNP
cord-183197-dxmto1tu	66	11	of	of	IN
cord-183197-dxmto1tu	66	12	Chloroquine	Chloroquine	NNP
cord-183197-dxmto1tu	66	13	,	,	,
cord-183197-dxmto1tu	66	14	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-183197-dxmto1tu	66	15	and	and	CC
cord-183197-dxmto1tu	66	16	its	-PRON-	PRP$
cord-183197-dxmto1tu	66	17	derivatives	derivative	NNS
cord-183197-dxmto1tu	66	18	for	for	IN
cord-183197-dxmto1tu	66	19	their	-PRON-	PRP$
cord-183197-dxmto1tu	66	20	binding	bind	VBG
cord-183197-dxmto1tu	66	21	affinity	affinity	NN
cord-183197-dxmto1tu	66	22	to	to	IN
cord-183197-dxmto1tu	66	23	multiple	multiple	JJ
cord-183197-dxmto1tu	66	24	SARS	SARS	NNP
cord-183197-dxmto1tu	66	25	-	-	HYPH
cord-183197-dxmto1tu	66	26	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	66	27	protein	protein	NN
cord-183197-dxmto1tu	66	28	drug	drug	NN
cord-183197-dxmto1tu	66	29	targets	target	NNS
cord-183197-dxmto1tu	67	1	The	the	DT
cord-183197-dxmto1tu	67	2	Molecular	Molecular	NNP
cord-183197-dxmto1tu	67	3	Docking	Docking	NNP
cord-183197-dxmto1tu	67	4	Study	Study	NNP
cord-183197-dxmto1tu	67	5	of	of	IN
cord-183197-dxmto1tu	67	6	Potential	Potential	NNP
cord-183197-dxmto1tu	67	7	Drug	Drug	NNP
cord-183197-dxmto1tu	67	8	Candidates	candidate	NNS
cord-183197-dxmto1tu	67	9	Showing	show	VBG
cord-183197-dxmto1tu	67	10	Anti	Anti	NNP
cord-183197-dxmto1tu	67	11	-	-	JJ
cord-183197-dxmto1tu	67	12	COVID-19	covid-19	JJ
cord-183197-dxmto1tu	67	13	Activity	Activity	NNP
cord-183197-dxmto1tu	67	14	by	by	IN
cord-183197-dxmto1tu	67	15	Exploring	explore	VBG
cord-183197-dxmto1tu	67	16	of	of	IN
cord-183197-dxmto1tu	67	17	Therapeutic	therapeutic	JJ
cord-183197-dxmto1tu	67	18	Targets	Targets	NNPS
cord-183197-dxmto1tu	67	19	of	of	IN
cord-183197-dxmto1tu	67	20	SARS	SARS	NNP
cord-183197-dxmto1tu	67	21	-	-	HYPH
cord-183197-dxmto1tu	67	22	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	67	23	Binding	Binding	NNP
cord-183197-dxmto1tu	67	24	efficiency	efficiency	NN
cord-183197-dxmto1tu	67	25	of	of	IN
cord-183197-dxmto1tu	67	26	protein	protein	NN
cord-183197-dxmto1tu	67	27	-	-	HYPH
cord-183197-dxmto1tu	67	28	protein	protein	NN
cord-183197-dxmto1tu	67	29	complexes	complex	NNS
cord-183197-dxmto1tu	67	30	Structure	Structure	NNP
cord-183197-dxmto1tu	67	31	of	of	IN
cord-183197-dxmto1tu	67	32	the	the	DT
cord-183197-dxmto1tu	67	33	SARS	SARS	NNP
cord-183197-dxmto1tu	67	34	-	-	HYPH
cord-183197-dxmto1tu	67	35	CoV-2	CoV-2	NNP
cord-183197-dxmto1tu	67	36	spike	spike	NN
cord-183197-dxmto1tu	67	37	receptor	receptor	NN
cord-183197-dxmto1tu	67	38	-	-	HYPH
cord-183197-dxmto1tu	67	39	binding	bind	VBG
cord-183197-dxmto1tu	67	40	domain	domain	NN
cord-183197-dxmto1tu	67	41	bound	bind	VBN
cord-183197-dxmto1tu	67	42	to	to	IN
cord-183197-dxmto1tu	67	43	the	the	DT
cord-183197-dxmto1tu	67	44	ACE2	ACE2	NNP
cord-183197-dxmto1tu	67	45	receptor	receptor	NN
cord-183197-dxmto1tu	67	46	Crystal	Crystal	NNP
cord-183197-dxmto1tu	67	47	structures	structure	NNS
cord-183197-dxmto1tu	67	48	of	of	IN
cord-183197-dxmto1tu	67	49	multidrug	multidrug	NN
cord-183197-dxmto1tu	67	50	binding	bind	VBG
cord-183197-dxmto1tu	67	51	protein	protein	NN
cord-183197-dxmto1tu	67	52	TtgR	TtgR	NNP
cord-183197-dxmto1tu	67	53	in	in	IN
cord-183197-dxmto1tu	67	54	complex	complex	NN
cord-183197-dxmto1tu	67	55	with	with	IN
cord-183197-dxmto1tu	67	56	antibiotics	antibiotic	NNS
cord-183197-dxmto1tu	67	57	and	and	CC
cord-183197-dxmto1tu	67	58	plant	plant	NN
cord-183197-dxmto1tu	67	59	antimicrobials	antimicrobial	NNS
cord-183197-dxmto1tu	67	60	cooperativity	cooperativity	NN
cord-183197-dxmto1tu	67	61	and	and	CC
cord-183197-dxmto1tu	67	62	stability	stability	NN
cord-183197-dxmto1tu	67	63	of	of	IN
cord-183197-dxmto1tu	67	64	the	the	DT
cord-183197-dxmto1tu	67	65	tetracycline	tetracycline	NNP
cord-183197-dxmto1tu	67	66	repressor	repressor	NN
cord-183197-dxmto1tu	67	67	(	(	-LRB-
cord-183197-dxmto1tu	67	68	TetR	TetR	NNP
cord-183197-dxmto1tu	67	69	)	)	-RRB-
cord-183197-dxmto1tu	67	70	upon	upon	IN
cord-183197-dxmto1tu	67	71	tetracycline	tetracycline	NNP
cord-183197-dxmto1tu	67	72	binding	bind	VBG
cord-183197-dxmto1tu	67	73	RosettaLigand	RosettaLigand	NNP
cord-183197-dxmto1tu	67	74	docking	docking	NN
cord-183197-dxmto1tu	67	75	with	with	IN
cord-183197-dxmto1tu	67	76	full	full	JJ
cord-183197-dxmto1tu	67	77	ligand	ligand	NN
cord-183197-dxmto1tu	67	78	and	and	CC
cord-183197-dxmto1tu	67	79	receptor	receptor	NN
cord-183197-dxmto1tu	67	80	flexibility	flexibility	NN
cord-183197-dxmto1tu	67	81	Rosetta	Rosetta	NNP
cord-183197-dxmto1tu	67	82	Ligand	Ligand	NNP
cord-183197-dxmto1tu	67	83	docking	docking	NN
cord-183197-dxmto1tu	67	84	with	with	IN
cord-183197-dxmto1tu	67	85	flexible	flexible	JJ
cord-183197-dxmto1tu	67	86	XML	xml	NN
cord-183197-dxmto1tu	67	87	protocols	protocol	NNS
cord-183197-dxmto1tu	67	88	ROSETTALIGAND	ROSETTALIGAND	NNP
cord-183197-dxmto1tu	67	89	:	:	:
cord-183197-dxmto1tu	68	1	protein	protein	NN
cord-183197-dxmto1tu	68	2	-	-	HYPH
cord-183197-dxmto1tu	68	3	small	small	JJ
cord-183197-dxmto1tu	68	4	molecule	molecule	NN
cord-183197-dxmto1tu	68	5	docking	docking	NN
cord-183197-dxmto1tu	68	6	with	with	IN
cord-183197-dxmto1tu	68	7	full	full	JJ
cord-183197-dxmto1tu	68	8	sidechain	sidechain	NN
cord-183197-dxmto1tu	68	9	flexibility	flexibility	NN
cord-183197-dxmto1tu	68	10	GROMACS	GROMACS	NNP
cord-183197-dxmto1tu	68	11	:	:	:
cord-183197-dxmto1tu	69	1	A	a	DT
cord-183197-dxmto1tu	69	2	message	message	NN
cord-183197-dxmto1tu	69	3	-	-	HYPH
cord-183197-dxmto1tu	69	4	passing	pass	VBG
cord-183197-dxmto1tu	69	5	parallel	parallel	JJ
cord-183197-dxmto1tu	69	6	molecular	molecular	JJ
cord-183197-dxmto1tu	69	7	dynamics	dynamic	NNS
cord-183197-dxmto1tu	69	8	implementation	implementation	NN
cord-183197-dxmto1tu	69	9	0	0	CD
cord-183197-dxmto1tu	69	10	:	:	:
cord-183197-dxmto1tu	69	11	a	a	DT
cord-183197-dxmto1tu	69	12	package	package	NN
cord-183197-dxmto1tu	69	13	for	for	IN
cord-183197-dxmto1tu	69	14	molecular	molecular	JJ
cord-183197-dxmto1tu	69	15	simulation	simulation	NN
cord-183197-dxmto1tu	69	16	and	and	CC
cord-183197-dxmto1tu	69	17	trajectory	trajectory	NN
cord-183197-dxmto1tu	69	18	analysis	analysis	NN
cord-183197-dxmto1tu	69	19	.	.	.
cord-183197-dxmto1tu	70	1	Molecular	molecular	JJ
cord-183197-dxmto1tu	70	2	modeling	model	VBG
cord-183197-dxmto1tu	70	3	annual	annual	JJ
cord-183197-dxmto1tu	70	4	A.	a.	NN
cord-183197-dxmto1tu	70	5	g_mmpbsa	g_mmpbsa	NN
cord-183197-dxmto1tu	71	1	-A	-A	NFP
cord-183197-dxmto1tu	71	2	GROMACS	GROMACS	NNP
cord-183197-dxmto1tu	71	3	Tool	Tool	NNP
cord-183197-dxmto1tu	71	4	for	for	IN
cord-183197-dxmto1tu	71	5	High	High	NNP
cord-183197-dxmto1tu	71	6	-	-	HYPH
cord-183197-dxmto1tu	71	7	Throughput	throughput	NN
cord-183197-dxmto1tu	72	1	MM	MM	NNP
cord-183197-dxmto1tu	72	2	-	-	HYPH
cord-183197-dxmto1tu	72	3	PBSA	PBSA	NNP
cord-183197-dxmto1tu	72	4	Calculations	Calculations	NNPS
cord-183197-dxmto1tu	72	5	Accurate	accurate	JJ
cord-183197-dxmto1tu	72	6	determination	determination	NN
cord-183197-dxmto1tu	72	7	of	of	IN
cord-183197-dxmto1tu	72	8	the	the	DT
cord-183197-dxmto1tu	72	9	binding	bind	VBG
cord-183197-dxmto1tu	72	10	free	free	JJ
cord-183197-dxmto1tu	72	11	energy	energy	NN
cord-183197-dxmto1tu	72	12	for	for	IN
cord-183197-dxmto1tu	72	13	KcsAcharybdotoxin	KcsAcharybdotoxin	NNP
cord-183197-dxmto1tu	72	14	complex	complex	NN
cord-183197-dxmto1tu	72	15	from	from	IN
cord-183197-dxmto1tu	72	16	the	the	DT
cord-183197-dxmto1tu	72	17	potential	potential	NN
cord-183197-dxmto1tu	72	18	of	of	IN
cord-183197-dxmto1tu	72	19	mean	mean	JJ
cord-183197-dxmto1tu	72	20	force	force	NN
cord-183197-dxmto1tu	72	21	calculations	calculation	NNS
cord-183197-dxmto1tu	72	22	with	with	IN
cord-183197-dxmto1tu	72	23	restraints	restraint	NNS
cord-183197-dxmto1tu	72	24	.	.	.
cord-183197-dxmto1tu	73	1	Biophysical	Biophysical	NNP
cord-183197-dxmto1tu	73	2	journal	journal	NN
cord-183197-dxmto1tu	74	1	Fast	fast	JJ
cord-183197-dxmto1tu	74	2	Parallel	Parallel	NNP
cord-183197-dxmto1tu	74	3	Algorithms	Algorithms	NNP
cord-183197-dxmto1tu	74	4	for	for	IN
cord-183197-dxmto1tu	74	5	Short	Short	NNP
cord-183197-dxmto1tu	74	6	-	-	HYPH
cord-183197-dxmto1tu	74	7	Range	Range	NNP
cord-183197-dxmto1tu	74	8	Molecular	Molecular	NNP
cord-183197-dxmto1tu	74	9	Dynamics	Dynamics	NNPS
cord-183197-dxmto1tu	74	10	CHARMM	CHARMM	NNP
cord-183197-dxmto1tu	74	11	:	:	:
cord-183197-dxmto1tu	74	12	the	the	DT
cord-183197-dxmto1tu	74	13	biomolecular	biomolecular	JJ
cord-183197-dxmto1tu	74	14	simulation	simulation	NN
cord-183197-dxmto1tu	74	15	program	program	NN
cord-183197-dxmto1tu	74	16	Computing	Computing	NNP
cord-183197-dxmto1tu	74	17	Equilibrium	Equilibrium	NNP
cord-183197-dxmto1tu	75	1	Free	Free	NNP
cord-183197-dxmto1tu	75	2	Energies	energy	NNS
cord-183197-dxmto1tu	76	1	Using	use	VBG
cord-183197-dxmto1tu	76	2	Non	Non	NNP
cord-183197-dxmto1tu	76	3	-	-	NNP
cord-183197-dxmto1tu	76	4	Equilibrium	equilibrium	JJ
cord-183197-dxmto1tu	76	5	Molecular	Molecular	NNP
cord-183197-dxmto1tu	76	6	Dynamics	Dynamics	NNPS
cord-183197-dxmto1tu	77	1	The	the	DT
cord-183197-dxmto1tu	77	2	authors	author	NNS
cord-183197-dxmto1tu	77	3	have	have	VBP
cord-183197-dxmto1tu	77	4	no	no	DT
cord-183197-dxmto1tu	77	5	competing	compete	VBG
cord-183197-dxmto1tu	77	6	financial	financial	JJ
cord-183197-dxmto1tu	77	7	interests	interest	NNS
cord-183197-dxmto1tu	77	8	or	or	CC
cord-183197-dxmto1tu	77	9	other	other	JJ
cord-183197-dxmto1tu	77	10	interests	interest	NNS
cord-183197-dxmto1tu	77	11	that	that	WDT
cord-183197-dxmto1tu	77	12	might	may	MD
cord-183197-dxmto1tu	77	13	be	be	VB
cord-183197-dxmto1tu	77	14	perceived	perceive	VBN
cord-183197-dxmto1tu	77	15	to	to	TO
cord-183197-dxmto1tu	77	16	influence	influence	VB
cord-183197-dxmto1tu	77	17	the	the	DT
cord-183197-dxmto1tu	77	18	results	result	NNS
cord-183197-dxmto1tu	78	1	and/or	and/or	CC
cord-183197-dxmto1tu	78	2	discussion	discussion	NN
cord-183197-dxmto1tu	78	3	reported	report	VBN
cord-183197-dxmto1tu	78	4	in	in	IN
cord-183197-dxmto1tu	78	5	this	this	DT
cord-183197-dxmto1tu	78	6	paper	paper	NN
cord-183197-dxmto1tu	78	7	.	.	.