id	sid	tid	token	lemma	pos
cord-048487-kamvao4b	1	1	key	key	JJ
cord-048487-kamvao4b	2	1	:	:	:
cord-048487-kamvao4b	2	2	cord-048487-kamvao4b	cord-048487-kamvao4b	NN
cord-048487-kamvao4b	2	3	authors	author	NNS
cord-048487-kamvao4b	2	4	:	:	:
cord-048487-kamvao4b	2	5	O'Brien	O'Brien	NNP
cord-048487-kamvao4b	2	6	,	,	,
cord-048487-kamvao4b	2	7	John	John	NNP
cord-048487-kamvao4b	2	8	D	D	NNP
cord-048487-kamvao4b	2	9	;	;	:
cord-048487-kamvao4b	2	10	She	-PRON-	PRP
cord-048487-kamvao4b	2	11	,	,	,
cord-048487-kamvao4b	2	12	Zhen	Zhen	NNP
cord-048487-kamvao4b	2	13	-	-	HYPH
cord-048487-kamvao4b	2	14	Su	Su	NNP
cord-048487-kamvao4b	2	15	;	;	:
cord-048487-kamvao4b	2	16	Suchard	Suchard	NNP
cord-048487-kamvao4b	2	17	,	,	,
cord-048487-kamvao4b	2	18	Marc	Marc	NNP
cord-048487-kamvao4b	2	19	A	a	DT
cord-048487-kamvao4b	2	20	title	title	NN
cord-048487-kamvao4b	2	21	:	:	:
cord-048487-kamvao4b	2	22	Dating	date	VBG
cord-048487-kamvao4b	2	23	the	the	DT
cord-048487-kamvao4b	2	24	time	time	NN
cord-048487-kamvao4b	2	25	of	of	IN
cord-048487-kamvao4b	2	26	viral	viral	JJ
cord-048487-kamvao4b	2	27	subtype	subtype	NN
cord-048487-kamvao4b	2	28	divergence	divergence	NN
cord-048487-kamvao4b	2	29	date	date	NN
cord-048487-kamvao4b	2	30	:	:	:
cord-048487-kamvao4b	2	31	2008	2008	CD
cord-048487-kamvao4b	2	32	-	-	SYM
cord-048487-kamvao4b	2	33	06	06	CD
cord-048487-kamvao4b	2	34	-	-	HYPH
cord-048487-kamvao4b	2	35	09	09	CD
cord-048487-kamvao4b	2	36	journal	journal	NN
cord-048487-kamvao4b	2	37	:	:	:
cord-048487-kamvao4b	3	1	BMC	BMC	NNP
cord-048487-kamvao4b	3	2	Evol	Evol	NNP
cord-048487-kamvao4b	3	3	Biol	Biol	NNP
cord-048487-kamvao4b	3	4	DOI	DOI	NNP
cord-048487-kamvao4b	3	5	:	:	:
cord-048487-kamvao4b	3	6	10.1186/1471	10.1186/1471	CD
cord-048487-kamvao4b	3	7	-	-	HYPH
cord-048487-kamvao4b	3	8	2148	2148	CD
cord-048487-kamvao4b	3	9	-	-	HYPH
cord-048487-kamvao4b	3	10	8	8	CD
cord-048487-kamvao4b	3	11	-	-	SYM
cord-048487-kamvao4b	3	12	172	172	CD
cord-048487-kamvao4b	3	13	sha	sha	NNP
cord-048487-kamvao4b	3	14	:	:	:
cord-048487-kamvao4b	3	15	341a9a57e865081e81a9c60b97802773761ce8c4	341a9a57e865081e81a9c60b97802773761ce8c4	CD
cord-048487-kamvao4b	3	16	doc_id	doc_id	CD
cord-048487-kamvao4b	3	17	:	:	:
cord-048487-kamvao4b	3	18	48487	48487	CD
cord-048487-kamvao4b	3	19	cord_uid	cord_uid	NNS
cord-048487-kamvao4b	3	20	:	:	:
cord-048487-kamvao4b	4	1	kamvao4b	kamvao4b	NNS
cord-048487-kamvao4b	5	1	Precise	precise	JJ
cord-048487-kamvao4b	5	2	dating	dating	NN
cord-048487-kamvao4b	5	3	of	of	IN
cord-048487-kamvao4b	5	4	viral	viral	JJ
cord-048487-kamvao4b	5	5	subtype	subtype	NN
cord-048487-kamvao4b	5	6	divergence	divergence	NN
cord-048487-kamvao4b	5	7	enables	enable	VBZ
cord-048487-kamvao4b	5	8	researchers	researcher	NNS
cord-048487-kamvao4b	5	9	to	to	TO
cord-048487-kamvao4b	5	10	correlate	correlate	VB
cord-048487-kamvao4b	5	11	divergence	divergence	NN
cord-048487-kamvao4b	5	12	with	with	IN
cord-048487-kamvao4b	5	13	geographic	geographic	JJ
cord-048487-kamvao4b	5	14	and	and	CC
cord-048487-kamvao4b	5	15	demographic	demographic	JJ
cord-048487-kamvao4b	5	16	occurrences	occurrence	NNS
cord-048487-kamvao4b	5	17	.	.	.
cord-048487-kamvao4b	6	1	When	when	WRB
cord-048487-kamvao4b	6	2	historical	historical	JJ
cord-048487-kamvao4b	6	3	data	datum	NNS
cord-048487-kamvao4b	6	4	are	be	VBP
cord-048487-kamvao4b	6	5	absent	absent	JJ
cord-048487-kamvao4b	6	6	(	(	-LRB-
cord-048487-kamvao4b	6	7	that	that	RB
cord-048487-kamvao4b	6	8	is	is	RB
cord-048487-kamvao4b	6	9	,	,	,
cord-048487-kamvao4b	6	10	the	the	DT
cord-048487-kamvao4b	6	11	overwhelming	overwhelming	JJ
cord-048487-kamvao4b	6	12	majority	majority	NN
cord-048487-kamvao4b	6	13	)	)	-RRB-
cord-048487-kamvao4b	6	14	,	,	,
cord-048487-kamvao4b	6	15	viral	viral	JJ
cord-048487-kamvao4b	6	16	sequence	sequence	NN
cord-048487-kamvao4b	6	17	sampling	sampling	NN
cord-048487-kamvao4b	6	18	on	on	IN
cord-048487-kamvao4b	6	19	a	a	DT
cord-048487-kamvao4b	6	20	time	time	NN
cord-048487-kamvao4b	6	21	scale	scale	NN
cord-048487-kamvao4b	6	22	commensurate	commensurate	NN
cord-048487-kamvao4b	6	23	with	with	IN
cord-048487-kamvao4b	6	24	the	the	DT
cord-048487-kamvao4b	6	25	rate	rate	NN
cord-048487-kamvao4b	6	26	of	of	IN
cord-048487-kamvao4b	6	27	substitution	substitution	NN
cord-048487-kamvao4b	6	28	permits	permit	VBZ
cord-048487-kamvao4b	6	29	the	the	DT
cord-048487-kamvao4b	6	30	inference	inference	NN
cord-048487-kamvao4b	6	31	of	of	IN
cord-048487-kamvao4b	6	32	the	the	DT
cord-048487-kamvao4b	6	33	times	time	NNS
cord-048487-kamvao4b	6	34	of	of	IN
cord-048487-kamvao4b	6	35	subtype	subtype	NN
cord-048487-kamvao4b	6	36	divergence	divergence	NN
cord-048487-kamvao4b	6	37	.	.	.
cord-048487-kamvao4b	7	1	Currently	currently	RB
cord-048487-kamvao4b	7	2	,	,	,
cord-048487-kamvao4b	7	3	researchers	researcher	NNS
cord-048487-kamvao4b	7	4	use	use	VBP
cord-048487-kamvao4b	7	5	two	two	CD
cord-048487-kamvao4b	7	6	strategies	strategy	NNS
cord-048487-kamvao4b	7	7	to	to	TO
cord-048487-kamvao4b	7	8	approach	approach	VB
cord-048487-kamvao4b	7	9	this	this	DT
cord-048487-kamvao4b	7	10	task	task	NN
cord-048487-kamvao4b	7	11	,	,	,
cord-048487-kamvao4b	7	12	both	both	DT
cord-048487-kamvao4b	7	13	requiring	require	VBG
cord-048487-kamvao4b	7	14	strong	strong	JJ
cord-048487-kamvao4b	7	15	conditions	condition	NNS
cord-048487-kamvao4b	7	16	on	on	IN
cord-048487-kamvao4b	7	17	the	the	DT
cord-048487-kamvao4b	7	18	molecular	molecular	JJ
cord-048487-kamvao4b	7	19	clock	clock	NN
cord-048487-kamvao4b	7	20	assumption	assumption	NN
cord-048487-kamvao4b	7	21	of	of	IN
cord-048487-kamvao4b	7	22	substitution	substitution	NN
cord-048487-kamvao4b	7	23	rate	rate	NN
cord-048487-kamvao4b	7	24	.	.	.
cord-048487-kamvao4b	8	1	As	as	IN
cord-048487-kamvao4b	8	2	the	the	DT
cord-048487-kamvao4b	8	3	underlying	underlying	JJ
cord-048487-kamvao4b	8	4	structure	structure	NN
cord-048487-kamvao4b	8	5	of	of	IN
cord-048487-kamvao4b	8	6	the	the	DT
cord-048487-kamvao4b	8	7	substitution	substitution	NN
cord-048487-kamvao4b	8	8	rate	rate	NN
cord-048487-kamvao4b	8	9	process	process	NN
cord-048487-kamvao4b	8	10	at	at	IN
cord-048487-kamvao4b	8	11	the	the	DT
cord-048487-kamvao4b	8	12	time	time	NN
cord-048487-kamvao4b	8	13	of	of	IN
cord-048487-kamvao4b	8	14	subtype	subtype	NN
cord-048487-kamvao4b	8	15	divergence	divergence	NN
cord-048487-kamvao4b	8	16	is	be	VBZ
cord-048487-kamvao4b	8	17	not	not	RB
cord-048487-kamvao4b	8	18	understood	understand	VBN
cord-048487-kamvao4b	8	19	and	and	CC
cord-048487-kamvao4b	8	20	likely	likely	RB
cord-048487-kamvao4b	8	21	highly	highly	RB
cord-048487-kamvao4b	8	22	variable	variable	JJ
cord-048487-kamvao4b	8	23	,	,	,
cord-048487-kamvao4b	8	24	we	-PRON-	PRP
cord-048487-kamvao4b	8	25	present	present	VBP
cord-048487-kamvao4b	8	26	a	a	DT
cord-048487-kamvao4b	8	27	simple	simple	JJ
cord-048487-kamvao4b	8	28	method	method	NN
cord-048487-kamvao4b	8	29	that	that	WDT
cord-048487-kamvao4b	8	30	estimates	estimate	VBZ
cord-048487-kamvao4b	8	31	rates	rate	NNS
cord-048487-kamvao4b	8	32	of	of	IN
cord-048487-kamvao4b	8	33	substitution	substitution	NN
cord-048487-kamvao4b	8	34	,	,	,
cord-048487-kamvao4b	8	35	and	and	CC
cord-048487-kamvao4b	8	36	from	from	IN
cord-048487-kamvao4b	8	37	there	there	RB
cord-048487-kamvao4b	8	38	,	,	,
cord-048487-kamvao4b	8	39	times	time	NNS
cord-048487-kamvao4b	8	40	of	of	IN
cord-048487-kamvao4b	8	41	divergence	divergence	NN
cord-048487-kamvao4b	8	42	,	,	,
cord-048487-kamvao4b	8	43	without	without	IN
cord-048487-kamvao4b	8	44	use	use	NN
cord-048487-kamvao4b	8	45	of	of	IN
cord-048487-kamvao4b	8	46	an	an	DT
cord-048487-kamvao4b	8	47	assumed	assumed	JJ
cord-048487-kamvao4b	8	48	molecular	molecular	JJ
cord-048487-kamvao4b	8	49	clock	clock	NN
cord-048487-kamvao4b	8	50	.	.	.
cord-048487-kamvao4b	9	1	We	-PRON-	PRP
cord-048487-kamvao4b	9	2	accomplish	accomplish	VBP
cord-048487-kamvao4b	9	3	this	this	DT
cord-048487-kamvao4b	9	4	by	by	IN
cord-048487-kamvao4b	9	5	blending	blend	VBG
cord-048487-kamvao4b	9	6	estimates	estimate	NNS
cord-048487-kamvao4b	9	7	of	of	IN
cord-048487-kamvao4b	9	8	the	the	DT
cord-048487-kamvao4b	9	9	substitution	substitution	NN
cord-048487-kamvao4b	9	10	rate	rate	NN
cord-048487-kamvao4b	9	11	for	for	IN
cord-048487-kamvao4b	9	12	triplets	triplet	NNS
cord-048487-kamvao4b	9	13	of	of	IN
cord-048487-kamvao4b	9	14	dated	date	VBN
cord-048487-kamvao4b	9	15	sequences	sequence	NNS
cord-048487-kamvao4b	9	16	where	where	WRB
cord-048487-kamvao4b	9	17	each	each	DT
cord-048487-kamvao4b	9	18	sequence	sequence	NN
cord-048487-kamvao4b	9	19	draws	draw	VBZ
cord-048487-kamvao4b	9	20	from	from	IN
cord-048487-kamvao4b	9	21	a	a	DT
cord-048487-kamvao4b	9	22	distinct	distinct	JJ
cord-048487-kamvao4b	9	23	viral	viral	JJ
cord-048487-kamvao4b	9	24	subtype	subtype	NN
cord-048487-kamvao4b	9	25	,	,	,
cord-048487-kamvao4b	9	26	providing	provide	VBG
cord-048487-kamvao4b	9	27	a	a	DT
cord-048487-kamvao4b	9	28	zeroth	zeroth	JJ
cord-048487-kamvao4b	9	29	-	-	HYPH
cord-048487-kamvao4b	9	30	order	order	NN
cord-048487-kamvao4b	9	31	approximation	approximation	NN
cord-048487-kamvao4b	9	32	for	for	IN
cord-048487-kamvao4b	9	33	the	the	DT
cord-048487-kamvao4b	9	34	rate	rate	NN
cord-048487-kamvao4b	9	35	between	between	IN
cord-048487-kamvao4b	9	36	subtypes	subtype	NNS
cord-048487-kamvao4b	9	37	.	.	.
cord-048487-kamvao4b	10	1	As	as	IN
cord-048487-kamvao4b	10	2	an	an	DT
cord-048487-kamvao4b	10	3	example	example	NN
cord-048487-kamvao4b	10	4	,	,	,
cord-048487-kamvao4b	10	5	we	-PRON-	PRP
cord-048487-kamvao4b	10	6	calculate	calculate	VBP
cord-048487-kamvao4b	10	7	the	the	DT
cord-048487-kamvao4b	10	8	time	time	NN
cord-048487-kamvao4b	10	9	of	of	IN
cord-048487-kamvao4b	10	10	divergence	divergence	NN
cord-048487-kamvao4b	10	11	for	for	IN
cord-048487-kamvao4b	10	12	three	three	CD
cord-048487-kamvao4b	10	13	genes	gene	NNS
cord-048487-kamvao4b	10	14	among	among	IN
cord-048487-kamvao4b	10	15	influenza	influenza	NN
cord-048487-kamvao4b	10	16	subtypes	subtype	NNS
cord-048487-kamvao4b	10	17	A	A	NNP
cord-048487-kamvao4b	10	18	-	-	:
cord-048487-kamvao4b	10	19	H3N2	H3N2	NNP
cord-048487-kamvao4b	10	20	and	and	CC
cord-048487-kamvao4b	10	21	B	b	NN
cord-048487-kamvao4b	10	22	using	use	VBG
cord-048487-kamvao4b	10	23	subtype	subtype	NN
cord-048487-kamvao4b	10	24	C	c	NN
cord-048487-kamvao4b	10	25	as	as	IN
cord-048487-kamvao4b	10	26	an	an	DT
cord-048487-kamvao4b	10	27	outgroup	outgroup	NN
cord-048487-kamvao4b	10	28	.	.	.
cord-048487-kamvao4b	11	1	We	-PRON-	PRP
cord-048487-kamvao4b	11	2	show	show	VBP
cord-048487-kamvao4b	11	3	a	a	DT
cord-048487-kamvao4b	11	4	time	time	NN
cord-048487-kamvao4b	11	5	of	of	IN
cord-048487-kamvao4b	11	6	divergence	divergence	NN
cord-048487-kamvao4b	11	7	approximately	approximately	RB
cord-048487-kamvao4b	11	8	100	100	CD
cord-048487-kamvao4b	11	9	years	year	NNS
cord-048487-kamvao4b	11	10	ago	ago	RB
cord-048487-kamvao4b	11	11	,	,	,
cord-048487-kamvao4b	11	12	substantially	substantially	RB
cord-048487-kamvao4b	11	13	more	more	RBR
cord-048487-kamvao4b	11	14	recent	recent	JJ
cord-048487-kamvao4b	11	15	than	than	IN
cord-048487-kamvao4b	11	16	previous	previous	JJ
cord-048487-kamvao4b	11	17	estimates	estimate	NNS
cord-048487-kamvao4b	11	18	which	which	WDT
cord-048487-kamvao4b	11	19	range	range	VBP
cord-048487-kamvao4b	11	20	from	from	IN
cord-048487-kamvao4b	11	21	250	250	CD
cord-048487-kamvao4b	11	22	to	to	TO
cord-048487-kamvao4b	11	23	3800	3800	CD
cord-048487-kamvao4b	11	24	years	year	NNS
cord-048487-kamvao4b	11	25	ago	ago	RB
cord-048487-kamvao4b	11	26	.	.	.
cord-048487-kamvao4b	12	1	Precise	precise	JJ
cord-048487-kamvao4b	12	2	estimates	estimate	NNS
cord-048487-kamvao4b	12	3	are	be	VBP
cord-048487-kamvao4b	12	4	sorely	sorely	RB
cord-048487-kamvao4b	12	5	lacking	lack	VBG
cord-048487-kamvao4b	12	6	for	for	IN
cord-048487-kamvao4b	12	7	dating	date	VBG
cord-048487-kamvao4b	12	8	the	the	DT
cord-048487-kamvao4b	12	9	emergence	emergence	NN
cord-048487-kamvao4b	12	10	and	and	CC
cord-048487-kamvao4b	12	11	divergence	divergence	NN
cord-048487-kamvao4b	12	12	of	of	IN
cord-048487-kamvao4b	12	13	viral	viral	JJ
cord-048487-kamvao4b	12	14	subtypes	subtype	NNS
cord-048487-kamvao4b	12	15	.	.	.
cord-048487-kamvao4b	13	1	Improved	improve	VBN
cord-048487-kamvao4b	13	2	estimates	estimate	NNS
cord-048487-kamvao4b	13	3	equip	equip	VBP
cord-048487-kamvao4b	13	4	epidemiologists	epidemiologist	NNS
cord-048487-kamvao4b	13	5	and	and	CC
cord-048487-kamvao4b	13	6	virologists	virologist	NNS
cord-048487-kamvao4b	13	7	to	to	TO
cord-048487-kamvao4b	13	8	begin	begin	VB
cord-048487-kamvao4b	13	9	to	to	TO
cord-048487-kamvao4b	13	10	correlate	correlate	VB
cord-048487-kamvao4b	13	11	these	these	DT
cord-048487-kamvao4b	13	12	important	important	JJ
cord-048487-kamvao4b	13	13	establishing	establish	VBG
cord-048487-kamvao4b	13	14	events	event	NNS
cord-048487-kamvao4b	13	15	with	with	IN
cord-048487-kamvao4b	13	16	historical	historical	JJ
cord-048487-kamvao4b	13	17	demographic	demographic	JJ
cord-048487-kamvao4b	13	18	changes	change	NNS
cord-048487-kamvao4b	13	19	,	,	,
cord-048487-kamvao4b	13	20	geographical	geographical	JJ
cord-048487-kamvao4b	13	21	invasions	invasion	NNS
cord-048487-kamvao4b	13	22	and	and	CC
cord-048487-kamvao4b	13	23	zoonoses	zoonosis	NNS
cord-048487-kamvao4b	13	24	,	,	,
cord-048487-kamvao4b	13	25	the	the	DT
cord-048487-kamvao4b	13	26	transferring	transferring	NN
cord-048487-kamvao4b	13	27	of	of	IN
cord-048487-kamvao4b	13	28	a	a	DT
cord-048487-kamvao4b	13	29	virus	virus	NN
cord-048487-kamvao4b	13	30	from	from	IN
cord-048487-kamvao4b	13	31	one	one	CD
cord-048487-kamvao4b	13	32	host	host	NN
cord-048487-kamvao4b	13	33	species	specie	NNS
cord-048487-kamvao4b	13	34	to	to	IN
cord-048487-kamvao4b	13	35	another	another	DT
cord-048487-kamvao4b	13	36	[	[	-LRB-
cord-048487-kamvao4b	13	37	7	7	CD
cord-048487-kamvao4b	13	38	,	,	,
cord-048487-kamvao4b	13	39	1	1	CD
cord-048487-kamvao4b	13	40	,	,	,
cord-048487-kamvao4b	13	41	25	25	CD
cord-048487-kamvao4b	13	42	]	]	-RRB-
cord-048487-kamvao4b	13	43	.	.	.
cord-048487-kamvao4b	14	1	For	for	IN
cord-048487-kamvao4b	14	2	example	example	NN
cord-048487-kamvao4b	14	3	,	,	,
cord-048487-kamvao4b	14	4	archeological	archeological	JJ
cord-048487-kamvao4b	14	5	sequence	sequence	NN
cord-048487-kamvao4b	14	6	data	datum	NNS
cord-048487-kamvao4b	14	7	can	can	MD
cord-048487-kamvao4b	14	8	furnish	furnish	VB
cord-048487-kamvao4b	14	9	accurate	accurate	JJ
cord-048487-kamvao4b	14	10	dates	date	NNS
cord-048487-kamvao4b	14	11	and	and	CC
cord-048487-kamvao4b	14	12	show	show	VBP
cord-048487-kamvao4b	14	13	that	that	IN
cord-048487-kamvao4b	14	14	substantial	substantial	JJ
cord-048487-kamvao4b	14	15	genomic	genomic	JJ
cord-048487-kamvao4b	14	16	changes	change	NNS
cord-048487-kamvao4b	14	17	associate	associate	VBP
cord-048487-kamvao4b	14	18	with	with	IN
cord-048487-kamvao4b	14	19	geographical	geographical	JJ
cord-048487-kamvao4b	14	20	invasion	invasion	NN
cord-048487-kamvao4b	14	21	and	and	CC
cord-048487-kamvao4b	14	22	zoonosis	zoonosis	NN
cord-048487-kamvao4b	14	23	[	[	-LRB-
cord-048487-kamvao4b	14	24	14	14	CD
cord-048487-kamvao4b	14	25	,	,	,
cord-048487-kamvao4b	14	26	17	17	CD
cord-048487-kamvao4b	14	27	]	]	-RRB-
cord-048487-kamvao4b	14	28	.	.	.
cord-048487-kamvao4b	15	1	Further	further	RB
cord-048487-kamvao4b	15	2	,	,	,
cord-048487-kamvao4b	15	3	the	the	DT
cord-048487-kamvao4b	15	4	recent	recent	JJ
cord-048487-kamvao4b	15	5	availability	availability	NN
cord-048487-kamvao4b	15	6	of	of	IN
cord-048487-kamvao4b	15	7	viral	viral	JJ
cord-048487-kamvao4b	15	8	gene	gene	NN
cord-048487-kamvao4b	15	9	sequences	sequence	NNS
cord-048487-kamvao4b	15	10	sampled	sample	VBN
cord-048487-kamvao4b	15	11	at	at	IN
cord-048487-kamvao4b	15	12	a	a	DT
cord-048487-kamvao4b	15	13	pace	pace	NN
cord-048487-kamvao4b	15	14	commensurate	commensurate	NN
cord-048487-kamvao4b	15	15	with	with	IN
cord-048487-kamvao4b	15	16	their	-PRON-	PRP$
cord-048487-kamvao4b	15	17	rate	rate	NN
cord-048487-kamvao4b	15	18	of	of	IN
cord-048487-kamvao4b	15	19	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	15	20	substitution	substitution	NN
cord-048487-kamvao4b	15	21	vastly	vastly	RB
cord-048487-kamvao4b	15	22	augments	augment	VBZ
cord-048487-kamvao4b	15	23	the	the	DT
cord-048487-kamvao4b	15	24	ability	ability	NN
cord-048487-kamvao4b	15	25	to	to	TO
cord-048487-kamvao4b	15	26	rigorously	rigorously	RB
cord-048487-kamvao4b	15	27	infer	infer	VB
cord-048487-kamvao4b	15	28	the	the	DT
cord-048487-kamvao4b	15	29	time	time	NN
cord-048487-kamvao4b	15	30	scale	scale	NN
cord-048487-kamvao4b	15	31	of	of	IN
cord-048487-kamvao4b	15	32	phylogenies	phylogeny	NNS
cord-048487-kamvao4b	15	33	and	and	CC
cord-048487-kamvao4b	15	34	hence	hence	RB
cord-048487-kamvao4b	15	35	determine	determine	VB
cord-048487-kamvao4b	15	36	the	the	DT
cord-048487-kamvao4b	15	37	time	time	NN
cord-048487-kamvao4b	15	38	of	of	IN
cord-048487-kamvao4b	15	39	the	the	DT
cord-048487-kamvao4b	15	40	most	most	RBS
cord-048487-kamvao4b	15	41	recent	recent	JJ
cord-048487-kamvao4b	15	42	common	common	JJ
cord-048487-kamvao4b	15	43	ancestor	ancestor	NN
cord-048487-kamvao4b	15	44	(	(	-LRB-
cord-048487-kamvao4b	15	45	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	15	46	)	)	-RRB-
cord-048487-kamvao4b	15	47	for	for	IN
cord-048487-kamvao4b	15	48	different	different	JJ
cord-048487-kamvao4b	15	49	viral	viral	JJ
cord-048487-kamvao4b	15	50	types	type	NNS
cord-048487-kamvao4b	15	51	[	[	-LRB-
cord-048487-kamvao4b	15	52	18	18	CD
cord-048487-kamvao4b	15	53	,	,	,
cord-048487-kamvao4b	15	54	26	26	CD
cord-048487-kamvao4b	15	55	,	,	,
cord-048487-kamvao4b	15	56	6	6	CD
cord-048487-kamvao4b	15	57	]	]	-RRB-
cord-048487-kamvao4b	15	58	.	.	.
cord-048487-kamvao4b	16	1	Systematic	systematic	JJ
cord-048487-kamvao4b	16	2	studies	study	NNS
cord-048487-kamvao4b	16	3	characterize	characterize	VBP
cord-048487-kamvao4b	16	4	the	the	DT
cord-048487-kamvao4b	16	5	substitution	substitution	NN
cord-048487-kamvao4b	16	6	process	process	NN
cord-048487-kamvao4b	16	7	and	and	CC
cord-048487-kamvao4b	16	8	substitution	substitution	NN
cord-048487-kamvao4b	16	9	rate	rate	NN
cord-048487-kamvao4b	16	10	process	process	NN
cord-048487-kamvao4b	16	11	of	of	IN
cord-048487-kamvao4b	16	12	several	several	JJ
cord-048487-kamvao4b	16	13	classes	class	NNS
cord-048487-kamvao4b	16	14	of	of	IN
cord-048487-kamvao4b	16	15	viral	viral	JJ
cord-048487-kamvao4b	16	16	subtypes	subtype	NNS
cord-048487-kamvao4b	16	17	in	in	IN
cord-048487-kamvao4b	16	18	,	,	,
cord-048487-kamvao4b	16	19	for	for	IN
cord-048487-kamvao4b	16	20	example	example	NN
cord-048487-kamvao4b	16	21	,	,	,
cord-048487-kamvao4b	16	22	Dengue	dengue	NN
cord-048487-kamvao4b	16	23	,	,	,
cord-048487-kamvao4b	16	24	influenza	influenza	NN
cord-048487-kamvao4b	16	25	subtype	subtype	NN
cord-048487-kamvao4b	16	26	A	A	NNP
cord-048487-kamvao4b	16	27	,	,	,
cord-048487-kamvao4b	16	28	human	human	JJ
cord-048487-kamvao4b	16	29	immunodeficiency	immunodeficiency	NN
cord-048487-kamvao4b	16	30	virus	virus	NN
cord-048487-kamvao4b	16	31	(	(	-LRB-
cord-048487-kamvao4b	16	32	HIV	HIV	NNP
cord-048487-kamvao4b	16	33	)	)	-RRB-
cord-048487-kamvao4b	16	34	and	and	CC
cord-048487-kamvao4b	16	35	the	the	DT
cord-048487-kamvao4b	16	36	virus	virus	NN
cord-048487-kamvao4b	16	37	responsible	responsible	JJ
cord-048487-kamvao4b	16	38	for	for	IN
cord-048487-kamvao4b	16	39	sudden	sudden	JJ
cord-048487-kamvao4b	16	40	acute	acute	JJ
cord-048487-kamvao4b	16	41	respiratory	respiratory	JJ
cord-048487-kamvao4b	16	42	syndrome	syndrome	NN
cord-048487-kamvao4b	16	43	(	(	-LRB-
cord-048487-kamvao4b	16	44	SARS	SARS	NNP
cord-048487-kamvao4b	16	45	)	)	-RRB-
cord-048487-kamvao4b	16	46	.	.	.
cord-048487-kamvao4b	17	1	For	for	IN
cord-048487-kamvao4b	17	2	the	the	DT
cord-048487-kamvao4b	17	3	last	last	JJ
cord-048487-kamvao4b	17	4	three	three	CD
cord-048487-kamvao4b	17	5	viruses	virus	NNS
cord-048487-kamvao4b	17	6	,	,	,
cord-048487-kamvao4b	17	7	a	a	DT
cord-048487-kamvao4b	17	8	unique	unique	JJ
cord-048487-kamvao4b	17	9	zoonotic	zoonotic	JJ
cord-048487-kamvao4b	17	10	transfer	transfer	NN
cord-048487-kamvao4b	17	11	appears	appear	VBZ
cord-048487-kamvao4b	17	12	to	to	TO
cord-048487-kamvao4b	17	13	co	co	VB
cord-048487-kamvao4b	17	14	-	-	VB
cord-048487-kamvao4b	17	15	occur	occur	VB
cord-048487-kamvao4b	17	16	with	with	IN
cord-048487-kamvao4b	17	17	substantial	substantial	JJ
cord-048487-kamvao4b	17	18	changes	change	NNS
cord-048487-kamvao4b	17	19	in	in	IN
cord-048487-kamvao4b	17	20	both	both	CC
cord-048487-kamvao4b	17	21	the	the	DT
cord-048487-kamvao4b	17	22	composition	composition	NN
cord-048487-kamvao4b	17	23	of	of	IN
cord-048487-kamvao4b	17	24	nucleotides	nucleotide	NNS
cord-048487-kamvao4b	17	25	and	and	CC
cord-048487-kamvao4b	17	26	amino	amino	JJ
cord-048487-kamvao4b	17	27	acids	acid	NNS
cord-048487-kamvao4b	17	28	as	as	RB
cord-048487-kamvao4b	17	29	well	well	RB
cord-048487-kamvao4b	17	30	as	as	IN
cord-048487-kamvao4b	17	31	alterations	alteration	NNS
cord-048487-kamvao4b	17	32	in	in	IN
cord-048487-kamvao4b	17	33	the	the	DT
cord-048487-kamvao4b	17	34	rate	rate	NN
cord-048487-kamvao4b	17	35	of	of	IN
cord-048487-kamvao4b	17	36	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	17	37	substitution	substitution	NN
cord-048487-kamvao4b	17	38	[	[	-LRB-
cord-048487-kamvao4b	17	39	15	15	CD
cord-048487-kamvao4b	17	40	,	,	,
cord-048487-kamvao4b	17	41	14	14	CD
cord-048487-kamvao4b	17	42	,	,	,
cord-048487-kamvao4b	17	43	1	1	CD
cord-048487-kamvao4b	17	44	]	]	-RRB-
cord-048487-kamvao4b	17	45	.	.	.
cord-048487-kamvao4b	18	1	In	in	IN
cord-048487-kamvao4b	18	2	Dengue	Dengue	NNP
cord-048487-kamvao4b	18	3	,	,	,
cord-048487-kamvao4b	18	4	where	where	WRB
cord-048487-kamvao4b	18	5	a	a	DT
cord-048487-kamvao4b	18	6	single	single	JJ
cord-048487-kamvao4b	18	7	subtype	subtype	NN
cord-048487-kamvao4b	18	8	simultaneously	simultaneously	RB
cord-048487-kamvao4b	18	9	inhabits	inhabit	VBZ
cord-048487-kamvao4b	18	10	two	two	CD
cord-048487-kamvao4b	18	11	hosts	host	NNS
cord-048487-kamvao4b	18	12	(	(	-LRB-
cord-048487-kamvao4b	18	13	humans	human	NNS
cord-048487-kamvao4b	18	14	and	and	CC
cord-048487-kamvao4b	18	15	Aedes	Aedes	NNP
cord-048487-kamvao4b	18	16	aegypti	aegypti	NNS
cord-048487-kamvao4b	18	17	)	)	-RRB-
cord-048487-kamvao4b	18	18	in	in	IN
cord-048487-kamvao4b	18	19	a	a	DT
cord-048487-kamvao4b	18	20	persistent	persistent	JJ
cord-048487-kamvao4b	18	21	zoonotic	zoonotic	JJ
cord-048487-kamvao4b	18	22	process	process	NN
cord-048487-kamvao4b	18	23	,	,	,
cord-048487-kamvao4b	18	24	the	the	DT
cord-048487-kamvao4b	18	25	introduction	introduction	NN
cord-048487-kamvao4b	18	26	of	of	IN
cord-048487-kamvao4b	18	27	the	the	DT
cord-048487-kamvao4b	18	28	virus	virus	NN
cord-048487-kamvao4b	18	29	to	to	IN
cord-048487-kamvao4b	18	30	new	new	JJ
cord-048487-kamvao4b	18	31	geographical	geographical	JJ
cord-048487-kamvao4b	18	32	environments	environment	NNS
cord-048487-kamvao4b	18	33	associates	associate	NNS
cord-048487-kamvao4b	18	34	with	with	IN
cord-048487-kamvao4b	18	35	a	a	DT
cord-048487-kamvao4b	18	36	dramatic	dramatic	JJ
cord-048487-kamvao4b	18	37	increase	increase	NN
cord-048487-kamvao4b	18	38	in	in	IN
cord-048487-kamvao4b	18	39	sequence	sequence	NN
cord-048487-kamvao4b	18	40	diversity	diversity	NN
cord-048487-kamvao4b	18	41	[	[	-LRB-
cord-048487-kamvao4b	18	42	25	25	CD
cord-048487-kamvao4b	18	43	]	]	-RRB-
cord-048487-kamvao4b	18	44	.	.	.
cord-048487-kamvao4b	19	1	Unfortunately	unfortunately	RB
cord-048487-kamvao4b	19	2	,	,	,
cord-048487-kamvao4b	19	3	no	no	DT
cord-048487-kamvao4b	19	4	studies	study	NNS
cord-048487-kamvao4b	19	5	thus	thus	RB
cord-048487-kamvao4b	19	6	far	far	RB
cord-048487-kamvao4b	19	7	analyze	analyze	VBP
cord-048487-kamvao4b	19	8	the	the	DT
cord-048487-kamvao4b	19	9	rate	rate	NN
cord-048487-kamvao4b	19	10	of	of	IN
cord-048487-kamvao4b	19	11	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	19	12	substitution	substitution	NN
cord-048487-kamvao4b	19	13	during	during	IN
cord-048487-kamvao4b	19	14	either	either	DT
cord-048487-kamvao4b	19	15	geographical	geographical	JJ
cord-048487-kamvao4b	19	16	invasion	invasion	NN
cord-048487-kamvao4b	19	17	or	or	CC
cord-048487-kamvao4b	19	18	zoonosis	zoonosis	NN
cord-048487-kamvao4b	19	19	.	.	.
cord-048487-kamvao4b	20	1	Consequently	consequently	RB
cord-048487-kamvao4b	20	2	,	,	,
cord-048487-kamvao4b	20	3	studies	study	NNS
cord-048487-kamvao4b	20	4	of	of	IN
cord-048487-kamvao4b	20	5	the	the	DT
cord-048487-kamvao4b	20	6	date	date	NN
cord-048487-kamvao4b	20	7	of	of	IN
cord-048487-kamvao4b	20	8	origins	origin	NNS
cord-048487-kamvao4b	20	9	of	of	IN
cord-048487-kamvao4b	20	10	viral	viral	JJ
cord-048487-kamvao4b	20	11	subtypes	subtype	NNS
cord-048487-kamvao4b	20	12	must	must	MD
cord-048487-kamvao4b	20	13	use	use	VB
cord-048487-kamvao4b	20	14	strong	strong	JJ
cord-048487-kamvao4b	20	15	a	a	DT
cord-048487-kamvao4b	20	16	priori	priori	FW
cord-048487-kamvao4b	20	17	assumptions	assumption	NNS
cord-048487-kamvao4b	20	18	on	on	IN
cord-048487-kamvao4b	20	19	the	the	DT
cord-048487-kamvao4b	20	20	rate	rate	NN
cord-048487-kamvao4b	20	21	structure	structure	NN
cord-048487-kamvao4b	20	22	of	of	IN
cord-048487-kamvao4b	20	23	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	20	24	substitution	substitution	NN
cord-048487-kamvao4b	20	25	.	.	.
cord-048487-kamvao4b	21	1	Two	two	CD
cord-048487-kamvao4b	21	2	primary	primary	JJ
cord-048487-kamvao4b	21	3	methods	method	NNS
cord-048487-kamvao4b	21	4	find	find	VBP
cord-048487-kamvao4b	21	5	use	use	NN
cord-048487-kamvao4b	21	6	to	to	IN
cord-048487-kamvao4b	21	7	date	date	NN
cord-048487-kamvao4b	21	8	the	the	DT
cord-048487-kamvao4b	21	9	time	time	NN
cord-048487-kamvao4b	21	10	of	of	IN
cord-048487-kamvao4b	21	11	viral	viral	JJ
cord-048487-kamvao4b	21	12	subtype	subtype	NN
cord-048487-kamvao4b	21	13	divergence	divergence	NN
cord-048487-kamvao4b	21	14	.	.	.
cord-048487-kamvao4b	22	1	The	the	DT
cord-048487-kamvao4b	22	2	most	most	RBS
cord-048487-kamvao4b	22	3	commonly	commonly	RB
cord-048487-kamvao4b	22	4	employed	employ	VBN
cord-048487-kamvao4b	22	5	approach	approach	NN
cord-048487-kamvao4b	22	6	determines	determine	VBZ
cord-048487-kamvao4b	22	7	the	the	DT
cord-048487-kamvao4b	22	8	divergence	divergence	NN
cord-048487-kamvao4b	22	9	time	time	NN
cord-048487-kamvao4b	22	10	of	of	IN
cord-048487-kamvao4b	22	11	subtypes	subtype	NNS
cord-048487-kamvao4b	22	12	using	use	VBG
cord-048487-kamvao4b	22	13	a	a	DT
cord-048487-kamvao4b	22	14	molecular	molecular	JJ
cord-048487-kamvao4b	22	15	clock	clock	NN
cord-048487-kamvao4b	22	16	assumption	assumption	NN
cord-048487-kamvao4b	22	17	(	(	-LRB-
cord-048487-kamvao4b	22	18	MCA	MCA	NNP
cord-048487-kamvao4b	22	19	)	)	-RRB-
cord-048487-kamvao4b	22	20	over	over	IN
cord-048487-kamvao4b	22	21	an	an	DT
cord-048487-kamvao4b	22	22	entire	entire	JJ
cord-048487-kamvao4b	22	23	phylogeny	phylogeny	NN
cord-048487-kamvao4b	22	24	[	[	-LRB-
cord-048487-kamvao4b	22	25	18	18	CD
cord-048487-kamvao4b	22	26	,	,	,
cord-048487-kamvao4b	22	27	21	21	CD
cord-048487-kamvao4b	22	28	,	,	,
cord-048487-kamvao4b	22	29	5	5	CD
cord-048487-kamvao4b	22	30	,	,	,
cord-048487-kamvao4b	22	31	26	26	CD
cord-048487-kamvao4b	22	32	]	]	-RRB-
cord-048487-kamvao4b	22	33	.	.	.
cord-048487-kamvao4b	23	1	In	in	IN
cord-048487-kamvao4b	23	2	its	-PRON-	PRP$
cord-048487-kamvao4b	23	3	strict	strict	JJ
cord-048487-kamvao4b	23	4	formulation	formulation	NN
cord-048487-kamvao4b	23	5	,	,	,
cord-048487-kamvao4b	23	6	the	the	DT
cord-048487-kamvao4b	23	7	MCA	MCA	NNP
cord-048487-kamvao4b	23	8	posits	posit	VBZ
cord-048487-kamvao4b	23	9	a	a	DT
cord-048487-kamvao4b	23	10	proportional	proportional	JJ
cord-048487-kamvao4b	23	11	relation	relation	NN
cord-048487-kamvao4b	23	12	between	between	IN
cord-048487-kamvao4b	23	13	the	the	DT
cord-048487-kamvao4b	23	14	number	number	NN
cord-048487-kamvao4b	23	15	of	of	IN
cord-048487-kamvao4b	23	16	substitutions	substitution	NNS
cord-048487-kamvao4b	23	17	and	and	CC
cord-048487-kamvao4b	23	18	the	the	DT
cord-048487-kamvao4b	23	19	intervening	intervene	VBG
cord-048487-kamvao4b	23	20	time	time	NN
cord-048487-kamvao4b	23	21	period	period	NN
cord-048487-kamvao4b	23	22	over	over	IN
cord-048487-kamvao4b	23	23	the	the	DT
cord-048487-kamvao4b	23	24	entire	entire	JJ
cord-048487-kamvao4b	23	25	phylogeny	phylogeny	NN
cord-048487-kamvao4b	23	26	.	.	.
cord-048487-kamvao4b	24	1	Looser	loose	JJR
cord-048487-kamvao4b	24	2	forms	form	NNS
cord-048487-kamvao4b	24	3	of	of	IN
cord-048487-kamvao4b	24	4	MCAs	mca	NNS
cord-048487-kamvao4b	24	5	require	require	VBP
cord-048487-kamvao4b	24	6	only	only	RB
cord-048487-kamvao4b	24	7	that	that	IN
cord-048487-kamvao4b	24	8	the	the	DT
cord-048487-kamvao4b	24	9	proportionality	proportionality	NN
cord-048487-kamvao4b	24	10	hold	hold	NN
cord-048487-kamvao4b	24	11	along	along	IN
cord-048487-kamvao4b	24	12	individual	individual	JJ
cord-048487-kamvao4b	24	13	branches	branch	NNS
cord-048487-kamvao4b	24	14	,	,	,
cord-048487-kamvao4b	24	15	with	with	IN
cord-048487-kamvao4b	24	16	the	the	DT
cord-048487-kamvao4b	24	17	rates	rate	NNS
cord-048487-kamvao4b	24	18	across	across	IN
cord-048487-kamvao4b	24	19	branches	branch	NNS
cord-048487-kamvao4b	24	20	drawn	draw	VBN
cord-048487-kamvao4b	24	21	from	from	IN
cord-048487-kamvao4b	24	22	a	a	DT
cord-048487-kamvao4b	24	23	pre	pre	JJ
cord-048487-kamvao4b	24	24	-	-	JJ
cord-048487-kamvao4b	24	25	specified	specified	JJ
cord-048487-kamvao4b	24	26	distribution	distribution	NN
cord-048487-kamvao4b	24	27	[	[	-LRB-
cord-048487-kamvao4b	24	28	5	5	CD
cord-048487-kamvao4b	24	29	]	]	-RRB-
cord-048487-kamvao4b	24	30	.	.	.
cord-048487-kamvao4b	25	1	Committed	commit	VBN
cord-048487-kamvao4b	25	2	to	to	IN
cord-048487-kamvao4b	25	3	some	some	DT
cord-048487-kamvao4b	25	4	variant	variant	NN
cord-048487-kamvao4b	25	5	of	of	IN
cord-048487-kamvao4b	25	6	the	the	DT
cord-048487-kamvao4b	25	7	MCA	MCA	NNP
cord-048487-kamvao4b	25	8	,	,	,
cord-048487-kamvao4b	25	9	current	current	JJ
cord-048487-kamvao4b	25	10	algorithms	algorithm	NNS
cord-048487-kamvao4b	25	11	then	then	RB
cord-048487-kamvao4b	25	12	estimate	estimate	VBP
cord-048487-kamvao4b	25	13	the	the	DT
cord-048487-kamvao4b	25	14	rate	rate	NN
cord-048487-kamvao4b	25	15	of	of	IN
cord-048487-kamvao4b	25	16	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	25	17	substitution	substitution	NN
cord-048487-kamvao4b	25	18	over	over	IN
cord-048487-kamvao4b	25	19	all	all	DT
cord-048487-kamvao4b	25	20	taxa	taxon	NNS
cord-048487-kamvao4b	25	21	in	in	IN
cord-048487-kamvao4b	25	22	a	a	DT
cord-048487-kamvao4b	25	23	given	give	VBN
cord-048487-kamvao4b	25	24	set	set	NN
cord-048487-kamvao4b	25	25	.	.	.
cord-048487-kamvao4b	26	1	Consequently	consequently	RB
cord-048487-kamvao4b	26	2	,	,	,
cord-048487-kamvao4b	26	3	these	these	DT
cord-048487-kamvao4b	26	4	methods	method	NNS
cord-048487-kamvao4b	26	5	provide	provide	VBP
cord-048487-kamvao4b	26	6	inference	inference	NN
cord-048487-kamvao4b	26	7	most	most	RBS
cord-048487-kamvao4b	26	8	suitable	suitable	JJ
cord-048487-kamvao4b	26	9	for	for	IN
cord-048487-kamvao4b	26	10	situations	situation	NNS
cord-048487-kamvao4b	26	11	where	where	WRB
cord-048487-kamvao4b	26	12	sequence	sequence	NN
cord-048487-kamvao4b	26	13	evolution	evolution	NN
cord-048487-kamvao4b	26	14	follows	follow	VBZ
cord-048487-kamvao4b	26	15	a	a	DT
cord-048487-kamvao4b	26	16	MCA	MCA	NNP
cord-048487-kamvao4b	26	17	(	(	-LRB-
cord-048487-kamvao4b	26	18	e.g.	e.g.	RB
cord-048487-kamvao4b	26	19	influenza	influenza	NN
cord-048487-kamvao4b	26	20	A	A	NNP
cord-048487-kamvao4b	26	21	-	-	:
cord-048487-kamvao4b	26	22	H3N2	H3N2	NNP
cord-048487-kamvao4b	26	23	in	in	IN
cord-048487-kamvao4b	26	24	human	human	JJ
cord-048487-kamvao4b	26	25	hosts	host	NNS
cord-048487-kamvao4b	26	26	,	,	,
cord-048487-kamvao4b	26	27	as	as	IN
cord-048487-kamvao4b	26	28	in	in	IN
cord-048487-kamvao4b	26	29	[	[	-LRB-
cord-048487-kamvao4b	26	30	9	9	CD
cord-048487-kamvao4b	26	31	]	]	-RRB-
cord-048487-kamvao4b	26	32	)	)	-RRB-
cord-048487-kamvao4b	26	33	or	or	CC
cord-048487-kamvao4b	26	34	deviates	deviate	VBZ
cord-048487-kamvao4b	26	35	from	from	IN
cord-048487-kamvao4b	26	36	the	the	DT
cord-048487-kamvao4b	26	37	MCA	MCA	NNP
cord-048487-kamvao4b	26	38	homogenously	homogenously	RB
cord-048487-kamvao4b	26	39	in	in	IN
cord-048487-kamvao4b	26	40	time	time	NN
cord-048487-kamvao4b	26	41	(	(	-LRB-
cord-048487-kamvao4b	26	42	e.g.	e.g.	RB
cord-048487-kamvao4b	26	43	perhaps	perhaps	RB
cord-048487-kamvao4b	26	44	influenza	influenza	NN
cord-048487-kamvao4b	26	45	A	a	NN
cord-048487-kamvao4b	26	46	in	in	IN
cord-048487-kamvao4b	26	47	wild	wild	JJ
cord-048487-kamvao4b	26	48	fowl	fowl	NN
cord-048487-kamvao4b	26	49	,	,	,
cord-048487-kamvao4b	26	50	see	see	VB
cord-048487-kamvao4b	26	51	[	[	-LRB-
cord-048487-kamvao4b	26	52	3	3	CD
cord-048487-kamvao4b	26	53	]	]	-RRB-
cord-048487-kamvao4b	26	54	)	)	-RRB-
cord-048487-kamvao4b	26	55	.	.	.
cord-048487-kamvao4b	27	1	In	in	IN
cord-048487-kamvao4b	27	2	considering	consider	VBG
cord-048487-kamvao4b	27	3	divergence	divergence	NN
cord-048487-kamvao4b	27	4	events	event	NNS
cord-048487-kamvao4b	27	5	between	between	IN
cord-048487-kamvao4b	27	6	viral	viral	JJ
cord-048487-kamvao4b	27	7	subtypes	subtype	NNS
cord-048487-kamvao4b	27	8	,	,	,
cord-048487-kamvao4b	27	9	even	even	RB
cord-048487-kamvao4b	27	10	when	when	WRB
cord-048487-kamvao4b	27	11	the	the	DT
cord-048487-kamvao4b	27	12	MCA	MCA	NNP
cord-048487-kamvao4b	27	13	well	well	RB
cord-048487-kamvao4b	27	14	-	-	HYPH
cord-048487-kamvao4b	27	15	approximates	approximate	VBZ
cord-048487-kamvao4b	27	16	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	27	17	substitution	substitution	NN
cord-048487-kamvao4b	27	18	within	within	IN
cord-048487-kamvao4b	27	19	a	a	DT
cord-048487-kamvao4b	27	20	given	give	VBN
cord-048487-kamvao4b	27	21	subtype	subtype	NN
cord-048487-kamvao4b	27	22	,	,	,
cord-048487-kamvao4b	27	23	the	the	DT
cord-048487-kamvao4b	27	24	above	above	JJ
cord-048487-kamvao4b	27	25	methods	method	NNS
cord-048487-kamvao4b	27	26	may	may	MD
cord-048487-kamvao4b	27	27	incorrectly	incorrectly	RB
cord-048487-kamvao4b	27	28	infer	infer	VB
cord-048487-kamvao4b	27	29	the	the	DT
cord-048487-kamvao4b	27	30	time	time	NN
cord-048487-kamvao4b	27	31	of	of	IN
cord-048487-kamvao4b	27	32	divergence	divergence	NN
cord-048487-kamvao4b	27	33	across	across	IN
cord-048487-kamvao4b	27	34	subtypes	subtype	NNS
cord-048487-kamvao4b	27	35	.	.	.
cord-048487-kamvao4b	28	1	By	by	IN
cord-048487-kamvao4b	28	2	either	either	CC
cord-048487-kamvao4b	28	3	assuming	assume	VBG
cord-048487-kamvao4b	28	4	that	that	IN
cord-048487-kamvao4b	28	5	a	a	DT
cord-048487-kamvao4b	28	6	single	single	JJ
cord-048487-kamvao4b	28	7	rate	rate	NN
cord-048487-kamvao4b	28	8	of	of	IN
cord-048487-kamvao4b	28	9	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	28	10	substitution	substitution	NN
cord-048487-kamvao4b	28	11	holds	hold	VBZ
cord-048487-kamvao4b	28	12	for	for	IN
cord-048487-kamvao4b	28	13	the	the	DT
cord-048487-kamvao4b	28	14	region	region	NN
cord-048487-kamvao4b	28	15	preceding	precede	VBG
cord-048487-kamvao4b	28	16	the	the	DT
cord-048487-kamvao4b	28	17	common	common	JJ
cord-048487-kamvao4b	28	18	ancestor	ancestor	NN
cord-048487-kamvao4b	28	19	of	of	IN
cord-048487-kamvao4b	28	20	each	each	DT
cord-048487-kamvao4b	28	21	subtype	subtype	NN
cord-048487-kamvao4b	28	22	or	or	CC
cord-048487-kamvao4b	28	23	by	by	IN
cord-048487-kamvao4b	28	24	smoothing	smooth	VBG
cord-048487-kamvao4b	28	25	the	the	DT
cord-048487-kamvao4b	28	26	rate	rate	NN
cord-048487-kamvao4b	28	27	of	of	IN
cord-048487-kamvao4b	28	28	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	28	29	substitution	substitution	NN
cord-048487-kamvao4b	28	30	over	over	IN
cord-048487-kamvao4b	28	31	clades	clade	NNS
cord-048487-kamvao4b	28	32	with	with	IN
cord-048487-kamvao4b	28	33	different	different	JJ
cord-048487-kamvao4b	28	34	numbers	number	NNS
cord-048487-kamvao4b	28	35	of	of	IN
cord-048487-kamvao4b	28	36	taxa	taxon	NNS
cord-048487-kamvao4b	28	37	,	,	,
cord-048487-kamvao4b	28	38	the	the	DT
cord-048487-kamvao4b	28	39	adherence	adherence	NN
cord-048487-kamvao4b	28	40	to	to	IN
cord-048487-kamvao4b	28	41	a	a	DT
cord-048487-kamvao4b	28	42	MCA	MCA	NNP
cord-048487-kamvao4b	28	43	prevents	prevent	VBZ
cord-048487-kamvao4b	28	44	direct	direct	JJ
cord-048487-kamvao4b	28	45	inference	inference	NN
cord-048487-kamvao4b	28	46	of	of	IN
cord-048487-kamvao4b	28	47	the	the	DT
cord-048487-kamvao4b	28	48	rate	rate	NN
cord-048487-kamvao4b	28	49	during	during	IN
cord-048487-kamvao4b	28	50	subtype	subtype	NN
cord-048487-kamvao4b	28	51	divergence	divergence	NN
cord-048487-kamvao4b	28	52	.	.	.
cord-048487-kamvao4b	29	1	Suzuki	Suzuki	NNP
cord-048487-kamvao4b	29	2	and	and	CC
cord-048487-kamvao4b	29	3	Nei	Nei	NNP
cord-048487-kamvao4b	29	4	(	(	-LRB-
cord-048487-kamvao4b	29	5	2002	2002	CD
cord-048487-kamvao4b	29	6	)	)	-RRB-
cord-048487-kamvao4b	29	7	propose	propose	VB
cord-048487-kamvao4b	29	8	an	an	DT
cord-048487-kamvao4b	29	9	alternative	alternative	NN
cord-048487-kamvao4b	29	10	,	,	,
cord-048487-kamvao4b	29	11	more	more	RBR
cord-048487-kamvao4b	29	12	heuristic	heuristic	JJ
cord-048487-kamvao4b	29	13	method	method	NN
cord-048487-kamvao4b	29	14	of	of	IN
cord-048487-kamvao4b	29	15	estimation	estimation	NN
cord-048487-kamvao4b	29	16	to	to	TO
cord-048487-kamvao4b	29	17	counteract	counteract	VB
cord-048487-kamvao4b	29	18	the	the	DT
cord-048487-kamvao4b	29	19	problem	problem	NN
cord-048487-kamvao4b	29	20	of	of	IN
cord-048487-kamvao4b	29	21	differing	differ	VBG
cord-048487-kamvao4b	29	22	rates	rate	NNS
cord-048487-kamvao4b	29	23	of	of	IN
cord-048487-kamvao4b	29	24	substitution	substitution	NN
cord-048487-kamvao4b	29	25	before	before	RB
cord-048487-kamvao4b	29	26	and	and	CC
cord-048487-kamvao4b	29	27	after	after	IN
cord-048487-kamvao4b	29	28	zoonotic	zoonotic	JJ
cord-048487-kamvao4b	29	29	events	event	NNS
cord-048487-kamvao4b	29	30	[	[	-LRB-
cord-048487-kamvao4b	29	31	23	23	CD
cord-048487-kamvao4b	29	32	,	,	,
cord-048487-kamvao4b	29	33	25	25	CD
cord-048487-kamvao4b	29	34	]	]	-RRB-
cord-048487-kamvao4b	29	35	.	.	.
cord-048487-kamvao4b	30	1	In	in	IN
cord-048487-kamvao4b	30	2	these	these	DT
cord-048487-kamvao4b	30	3	studies	study	NNS
cord-048487-kamvao4b	30	4	,	,	,
cord-048487-kamvao4b	30	5	the	the	DT
cord-048487-kamvao4b	30	6	evolutionary	evolutionary	JJ
cord-048487-kamvao4b	30	7	models	model	NNS
cord-048487-kamvao4b	30	8	draw	draw	VBP
cord-048487-kamvao4b	30	9	a	a	DT
cord-048487-kamvao4b	30	10	distinction	distinction	NN
cord-048487-kamvao4b	30	11	between	between	IN
cord-048487-kamvao4b	30	12	the	the	DT
cord-048487-kamvao4b	30	13	rate	rate	NN
cord-048487-kamvao4b	30	14	of	of	IN
cord-048487-kamvao4b	30	15	substitution	substitution	NN
cord-048487-kamvao4b	30	16	within	within	IN
cord-048487-kamvao4b	30	17	a	a	DT
cord-048487-kamvao4b	30	18	given	give	VBN
cord-048487-kamvao4b	30	19	subtype	subtype	NN
cord-048487-kamvao4b	30	20	and	and	CC
cord-048487-kamvao4b	30	21	the	the	DT
cord-048487-kamvao4b	30	22	rate	rate	NN
cord-048487-kamvao4b	30	23	of	of	IN
cord-048487-kamvao4b	30	24	substitution	substitution	NN
cord-048487-kamvao4b	30	25	between	between	IN
cord-048487-kamvao4b	30	26	subtypes	subtype	NNS
cord-048487-kamvao4b	30	27	.	.	.
cord-048487-kamvao4b	31	1	However	however	RB
cord-048487-kamvao4b	31	2	,	,	,
cord-048487-kamvao4b	31	3	trouble	trouble	NN
cord-048487-kamvao4b	31	4	arises	arise	VBZ
cord-048487-kamvao4b	31	5	since	since	IN
cord-048487-kamvao4b	31	6	there	there	EX
cord-048487-kamvao4b	31	7	are	be	VBP
cord-048487-kamvao4b	31	8	no	no	DT
cord-048487-kamvao4b	31	9	methods	method	NNS
cord-048487-kamvao4b	31	10	for	for	IN
cord-048487-kamvao4b	31	11	estimating	estimate	VBG
cord-048487-kamvao4b	31	12	the	the	DT
cord-048487-kamvao4b	31	13	latter	latter	JJ
cord-048487-kamvao4b	31	14	quantity	quantity	NN
cord-048487-kamvao4b	31	15	.	.	.
cord-048487-kamvao4b	32	1	Consequently	consequently	RB
cord-048487-kamvao4b	32	2	,	,	,
cord-048487-kamvao4b	32	3	the	the	DT
cord-048487-kamvao4b	32	4	models	model	NNS
cord-048487-kamvao4b	32	5	assume	assume	VBP
cord-048487-kamvao4b	32	6	that	that	IN
cord-048487-kamvao4b	32	7	the	the	DT
cord-048487-kamvao4b	32	8	rate	rate	NN
cord-048487-kamvao4b	32	9	of	of	IN
cord-048487-kamvao4b	32	10	substitution	substitution	NN
cord-048487-kamvao4b	32	11	for	for	IN
cord-048487-kamvao4b	32	12	portions	portion	NNS
cord-048487-kamvao4b	32	13	of	of	IN
cord-048487-kamvao4b	32	14	the	the	DT
cord-048487-kamvao4b	32	15	phylogeny	phylogeny	NN
cord-048487-kamvao4b	32	16	between	between	IN
cord-048487-kamvao4b	32	17	the	the	DT
cord-048487-kamvao4b	32	18	subtypes	subtype	NNS
cord-048487-kamvao4b	32	19	equals	equal	VBZ
cord-048487-kamvao4b	32	20	the	the	DT
cord-048487-kamvao4b	32	21	mean	mean	JJ
cord-048487-kamvao4b	32	22	rate	rate	NN
cord-048487-kamvao4b	32	23	in	in	IN
cord-048487-kamvao4b	32	24	the	the	DT
cord-048487-kamvao4b	32	25	initial	initial	JJ
cord-048487-kamvao4b	32	26	host	host	NN
cord-048487-kamvao4b	32	27	species	specie	VBZ
cord-048487-kamvao4b	32	28	population	population	NN
cord-048487-kamvao4b	32	29	.	.	.
cord-048487-kamvao4b	33	1	For	for	IN
cord-048487-kamvao4b	33	2	instance	instance	NN
cord-048487-kamvao4b	33	3	,	,	,
cord-048487-kamvao4b	33	4	in	in	IN
cord-048487-kamvao4b	33	5	dating	date	VBG
cord-048487-kamvao4b	33	6	the	the	DT
cord-048487-kamvao4b	33	7	time	time	NN
cord-048487-kamvao4b	33	8	of	of	IN
cord-048487-kamvao4b	33	9	divergence	divergence	NN
cord-048487-kamvao4b	33	10	between	between	IN
cord-048487-kamvao4b	33	11	influenza	influenza	NN
cord-048487-kamvao4b	33	12	B	b	NN
cord-048487-kamvao4b	33	13	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	33	14	and	and	CC
cord-048487-kamvao4b	33	15	influenza	influenza	NN
cord-048487-kamvao4b	33	16	C	c	CD
cord-048487-kamvao4b	33	17	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	33	18	-	-	HYPH
cord-048487-kamvao4b	33	19	esterase	esterase	NN
cord-048487-kamvao4b	33	20	,	,	,
cord-048487-kamvao4b	33	21	Suzuki	Suzuki	NNP
cord-048487-kamvao4b	33	22	and	and	CC
cord-048487-kamvao4b	33	23	Nei	Nei	NNP
cord-048487-kamvao4b	33	24	use	use	VBP
cord-048487-kamvao4b	33	25	the	the	DT
cord-048487-kamvao4b	33	26	rate	rate	NN
cord-048487-kamvao4b	33	27	of	of	IN
cord-048487-kamvao4b	33	28	amino	amino	NN
cord-048487-kamvao4b	33	29	acid	acid	NN
cord-048487-kamvao4b	33	30	substitution	substitution	NN
cord-048487-kamvao4b	33	31	for	for	IN
cord-048487-kamvao4b	33	32	water	water	NN
cord-048487-kamvao4b	33	33	fowl	fowl	NN
cord-048487-kamvao4b	33	34	for	for	IN
cord-048487-kamvao4b	33	35	the	the	DT
cord-048487-kamvao4b	33	36	portions	portion	NNS
cord-048487-kamvao4b	33	37	of	of	IN
cord-048487-kamvao4b	33	38	the	the	DT
cord-048487-kamvao4b	33	39	phylogeny	phylogeny	NN
cord-048487-kamvao4b	33	40	previous	previous	JJ
cord-048487-kamvao4b	33	41	to	to	IN
cord-048487-kamvao4b	33	42	the	the	DT
cord-048487-kamvao4b	33	43	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	33	44	of	of	IN
cord-048487-kamvao4b	33	45	these	these	DT
cord-048487-kamvao4b	33	46	two	two	CD
cord-048487-kamvao4b	33	47	proteins	protein	NNS
cord-048487-kamvao4b	33	48	[	[	-LRB-
cord-048487-kamvao4b	33	49	23	23	CD
cord-048487-kamvao4b	33	50	]	]	-RRB-
cord-048487-kamvao4b	33	51	.	.	.
cord-048487-kamvao4b	34	1	While	while	IN
cord-048487-kamvao4b	34	2	this	this	DT
cord-048487-kamvao4b	34	3	method	method	NN
cord-048487-kamvao4b	34	4	may	may	MD
cord-048487-kamvao4b	34	5	accurately	accurately	RB
cord-048487-kamvao4b	34	6	reflect	reflect	VB
cord-048487-kamvao4b	34	7	the	the	DT
cord-048487-kamvao4b	34	8	rate	rate	NN
cord-048487-kamvao4b	34	9	within	within	IN
cord-048487-kamvao4b	34	10	avian	avian	JJ
cord-048487-kamvao4b	34	11	and	and	CC
cord-048487-kamvao4b	34	12	human	human	JJ
cord-048487-kamvao4b	34	13	hosts	host	NNS
cord-048487-kamvao4b	34	14	,	,	,
cord-048487-kamvao4b	34	15	it	-PRON-	PRP
cord-048487-kamvao4b	34	16	neglects	neglect	VBZ
cord-048487-kamvao4b	34	17	whatever	whatever	WDT
cord-048487-kamvao4b	34	18	additional	additional	JJ
cord-048487-kamvao4b	34	19	changes	change	NNS
cord-048487-kamvao4b	34	20	in	in	IN
cord-048487-kamvao4b	34	21	the	the	DT
cord-048487-kamvao4b	34	22	rate	rate	NN
cord-048487-kamvao4b	34	23	of	of	IN
cord-048487-kamvao4b	34	24	substitution	substitution	NN
cord-048487-kamvao4b	34	25	are	be	VBP
cord-048487-kamvao4b	34	26	due	due	JJ
cord-048487-kamvao4b	34	27	to	to	IN
cord-048487-kamvao4b	34	28	the	the	DT
cord-048487-kamvao4b	34	29	process	process	NN
cord-048487-kamvao4b	34	30	of	of	IN
cord-048487-kamvao4b	34	31	zoonotic	zoonotic	JJ
cord-048487-kamvao4b	34	32	adaptation	adaptation	NN
cord-048487-kamvao4b	34	33	,	,	,
cord-048487-kamvao4b	34	34	likely	likely	RB
cord-048487-kamvao4b	34	35	leading	lead	VBG
cord-048487-kamvao4b	34	36	to	to	IN
cord-048487-kamvao4b	34	37	a	a	DT
cord-048487-kamvao4b	34	38	substantial	substantial	JJ
cord-048487-kamvao4b	34	39	underestimation	underestimation	NN
cord-048487-kamvao4b	34	40	of	of	IN
cord-048487-kamvao4b	34	41	the	the	DT
cord-048487-kamvao4b	34	42	date	date	NN
cord-048487-kamvao4b	34	43	of	of	IN
cord-048487-kamvao4b	34	44	the	the	DT
cord-048487-kamvao4b	34	45	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	34	46	.	.	.
cord-048487-kamvao4b	35	1	The	the	DT
cord-048487-kamvao4b	35	2	study	study	NN
cord-048487-kamvao4b	35	3	here	here	RB
cord-048487-kamvao4b	35	4	focuses	focus	VBZ
cord-048487-kamvao4b	35	5	on	on	IN
cord-048487-kamvao4b	35	6	influenza	influenza	NN
cord-048487-kamvao4b	35	7	,	,	,
cord-048487-kamvao4b	35	8	although	although	IN
cord-048487-kamvao4b	35	9	the	the	DT
cord-048487-kamvao4b	35	10	techniques	technique	NNS
cord-048487-kamvao4b	35	11	are	be	VBP
cord-048487-kamvao4b	35	12	readily	readily	RB
cord-048487-kamvao4b	35	13	applied	apply	VBN
cord-048487-kamvao4b	35	14	to	to	IN
cord-048487-kamvao4b	35	15	other	other	JJ
cord-048487-kamvao4b	35	16	rapidly	rapidly	RB
cord-048487-kamvao4b	35	17	evolving	evolve	VBG
cord-048487-kamvao4b	35	18	organisms	organism	NNS
cord-048487-kamvao4b	35	19	.	.	.
cord-048487-kamvao4b	36	1	Influenza	influenza	NN
cord-048487-kamvao4b	36	2	has	have	VBZ
cord-048487-kamvao4b	36	3	three	three	CD
cord-048487-kamvao4b	36	4	types	type	NNS
cord-048487-kamvao4b	36	5	,	,	,
cord-048487-kamvao4b	36	6	A	A	NNP
cord-048487-kamvao4b	36	7	,	,	,
cord-048487-kamvao4b	36	8	B	b	NN
cord-048487-kamvao4b	36	9	and	and	CC
cord-048487-kamvao4b	36	10	C	C	NNP
cord-048487-kamvao4b	36	11	,	,	,
cord-048487-kamvao4b	36	12	classified	classify	VBN
cord-048487-kamvao4b	36	13	based	base	VBN
cord-048487-kamvao4b	36	14	on	on	IN
cord-048487-kamvao4b	36	15	serological	serological	JJ
cord-048487-kamvao4b	36	16	analysis	analysis	NN
cord-048487-kamvao4b	36	17	.	.	.
cord-048487-kamvao4b	37	1	To	to	IN
cord-048487-kamvao4b	37	2	date	date	NN
cord-048487-kamvao4b	37	3	,	,	,
cord-048487-kamvao4b	37	4	only	only	RB
cord-048487-kamvao4b	37	5	type	type	NN
cord-048487-kamvao4b	37	6	A	a	DT
cord-048487-kamvao4b	37	7	sequences	sequence	NNS
cord-048487-kamvao4b	37	8	have	have	VBP
cord-048487-kamvao4b	37	9	been	be	VBN
cord-048487-kamvao4b	37	10	demonstrably	demonstrably	RB
cord-048487-kamvao4b	37	11	associated	associate	VBN
cord-048487-kamvao4b	37	12	with	with	IN
cord-048487-kamvao4b	37	13	global	global	JJ
cord-048487-kamvao4b	37	14	pandemics	pandemic	NNS
cord-048487-kamvao4b	37	15	[	[	-LRB-
cord-048487-kamvao4b	37	16	4	4	CD
cord-048487-kamvao4b	37	17	]	]	-RRB-
cord-048487-kamvao4b	37	18	.	.	.
cord-048487-kamvao4b	38	1	Since	since	IN
cord-048487-kamvao4b	38	2	modern	modern	JJ
cord-048487-kamvao4b	38	3	surveillance	surveillance	NN
cord-048487-kamvao4b	38	4	began	begin	VBD
cord-048487-kamvao4b	38	5	in	in	IN
cord-048487-kamvao4b	38	6	the	the	DT
cord-048487-kamvao4b	38	7	1930s	1930	NNS
cord-048487-kamvao4b	38	8	,	,	,
cord-048487-kamvao4b	38	9	type	type	NN
cord-048487-kamvao4b	38	10	B	b	NN
cord-048487-kamvao4b	38	11	has	have	VBZ
cord-048487-kamvao4b	38	12	only	only	RB
cord-048487-kamvao4b	38	13	been	be	VBN
cord-048487-kamvao4b	38	14	responsible	responsible	JJ
cord-048487-kamvao4b	38	15	for	for	IN
cord-048487-kamvao4b	38	16	mild	mild	JJ
cord-048487-kamvao4b	38	17	epidemics	epidemic	NNS
cord-048487-kamvao4b	38	18	while	while	IN
cord-048487-kamvao4b	38	19	type	type	NN
cord-048487-kamvao4b	38	20	C	C	NNP
cord-048487-kamvao4b	38	21	has	have	VBZ
cord-048487-kamvao4b	38	22	been	be	VBN
cord-048487-kamvao4b	38	23	nearly	nearly	RB
cord-048487-kamvao4b	38	24	asymptomatic	asymptomatic	JJ
cord-048487-kamvao4b	38	25	in	in	IN
cord-048487-kamvao4b	38	26	human	human	JJ
cord-048487-kamvao4b	38	27	infection	infection	NN
cord-048487-kamvao4b	38	28	.	.	.
cord-048487-kamvao4b	39	1	Several	several	JJ
cord-048487-kamvao4b	39	2	subtypes	subtype	NNS
cord-048487-kamvao4b	39	3	of	of	IN
cord-048487-kamvao4b	39	4	A	a	DT
cord-048487-kamvao4b	39	5	,	,	,
cord-048487-kamvao4b	39	6	notably	notably	RB
cord-048487-kamvao4b	39	7	H1N1	H1N1	NNP
cord-048487-kamvao4b	39	8	and	and	CC
cord-048487-kamvao4b	39	9	H3N2	H3N2	NNP
cord-048487-kamvao4b	39	10	,	,	,
cord-048487-kamvao4b	39	11	are	be	VBP
cord-048487-kamvao4b	39	12	currently	currently	RB
cord-048487-kamvao4b	39	13	co	co	NN
cord-048487-kamvao4b	39	14	-	-	NN
cord-048487-kamvao4b	39	15	circulating	circulate	VBG
cord-048487-kamvao4b	39	16	in	in	IN
cord-048487-kamvao4b	39	17	the	the	DT
cord-048487-kamvao4b	39	18	human	human	JJ
cord-048487-kamvao4b	39	19	population	population	NN
cord-048487-kamvao4b	39	20	.	.	.
cord-048487-kamvao4b	40	1	As	as	IN
cord-048487-kamvao4b	40	2	the	the	DT
cord-048487-kamvao4b	40	3	H1N1	H1N1	NNP
cord-048487-kamvao4b	40	4	and	and	CC
cord-048487-kamvao4b	40	5	H3N2	H3N2	NNP
cord-048487-kamvao4b	40	6	subtypes	subtype	NNS
cord-048487-kamvao4b	40	7	may	may	MD
cord-048487-kamvao4b	40	8	be	be	VB
cord-048487-kamvao4b	40	9	as	as	RB
cord-048487-kamvao4b	40	10	divergent	divergent	JJ
cord-048487-kamvao4b	40	11	from	from	IN
cord-048487-kamvao4b	40	12	each	each	DT
cord-048487-kamvao4b	40	13	other	other	JJ
cord-048487-kamvao4b	40	14	as	as	IN
cord-048487-kamvao4b	40	15	they	-PRON-	PRP
cord-048487-kamvao4b	40	16	are	be	VBP
cord-048487-kamvao4b	40	17	from	from	IN
cord-048487-kamvao4b	40	18	types	type	NNS
cord-048487-kamvao4b	40	19	B	b	NN
cord-048487-kamvao4b	40	20	and	and	CC
cord-048487-kamvao4b	40	21	C	C	NNP
cord-048487-kamvao4b	40	22	,	,	,
cord-048487-kamvao4b	40	23	we	-PRON-	PRP
cord-048487-kamvao4b	40	24	will	will	MD
cord-048487-kamvao4b	40	25	refer	refer	VB
cord-048487-kamvao4b	40	26	to	to	IN
cord-048487-kamvao4b	40	27	all	all	DT
cord-048487-kamvao4b	40	28	types	type	NNS
cord-048487-kamvao4b	40	29	and	and	CC
cord-048487-kamvao4b	40	30	subtypes	subtype	NNS
cord-048487-kamvao4b	40	31	simply	simply	RB
cord-048487-kamvao4b	40	32	as	as	IN
cord-048487-kamvao4b	40	33	subtypes	subtype	NNS
cord-048487-kamvao4b	40	34	for	for	IN
cord-048487-kamvao4b	40	35	the	the	DT
cord-048487-kamvao4b	40	36	remainder	remainder	NN
cord-048487-kamvao4b	40	37	of	of	IN
cord-048487-kamvao4b	40	38	this	this	DT
cord-048487-kamvao4b	40	39	paper	paper	NN
cord-048487-kamvao4b	40	40	.	.	.
cord-048487-kamvao4b	41	1	We	-PRON-	PRP
cord-048487-kamvao4b	41	2	select	select	VBP
cord-048487-kamvao4b	41	3	for	for	IN
cord-048487-kamvao4b	41	4	this	this	DT
cord-048487-kamvao4b	41	5	study	study	NN
cord-048487-kamvao4b	41	6	three	three	CD
cord-048487-kamvao4b	41	7	genes	gene	NNS
cord-048487-kamvao4b	41	8	,	,	,
cord-048487-kamvao4b	41	9	coding	code	VBG
cord-048487-kamvao4b	41	10	for	for	IN
cord-048487-kamvao4b	41	11	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	41	12	(	(	-LRB-
cord-048487-kamvao4b	41	13	HA	HA	NNP
cord-048487-kamvao4b	41	14	)	)	-RRB-
cord-048487-kamvao4b	41	15	,	,	,
cord-048487-kamvao4b	41	16	the	the	DT
cord-048487-kamvao4b	41	17	matrix	matrix	NN
cord-048487-kamvao4b	41	18	protein	protein	NN
cord-048487-kamvao4b	41	19	(	(	-LRB-
cord-048487-kamvao4b	41	20	MP	MP	NNP
cord-048487-kamvao4b	41	21	)	)	-RRB-
cord-048487-kamvao4b	41	22	and	and	CC
cord-048487-kamvao4b	41	23	the	the	DT
cord-048487-kamvao4b	41	24	non	non	JJ
cord-048487-kamvao4b	41	25	-	-	JJ
cord-048487-kamvao4b	41	26	structural	structural	JJ
cord-048487-kamvao4b	41	27	protein	protein	NN
cord-048487-kamvao4b	41	28	(	(	-LRB-
cord-048487-kamvao4b	41	29	NS	NS	NNP
cord-048487-kamvao4b	41	30	)	)	-RRB-
cord-048487-kamvao4b	41	31	responsible	responsible	JJ
cord-048487-kamvao4b	41	32	for	for	IN
cord-048487-kamvao4b	41	33	interfering	interfere	VBG
cord-048487-kamvao4b	41	34	with	with	IN
cord-048487-kamvao4b	41	35	host	host	NN
cord-048487-kamvao4b	41	36	immune	immune	JJ
cord-048487-kamvao4b	41	37	response	response	NN
cord-048487-kamvao4b	41	38	.	.	.
cord-048487-kamvao4b	42	1	Subtype	Subtype	NNP
cord-048487-kamvao4b	42	2	C	C	NNP
cord-048487-kamvao4b	42	3	has	have	VBZ
cord-048487-kamvao4b	42	4	a	a	DT
cord-048487-kamvao4b	42	5	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	42	6	-	-	HYPH
cord-048487-kamvao4b	42	7	esterase	esterase	NN
cord-048487-kamvao4b	42	8	gene	gene	NN
cord-048487-kamvao4b	42	9	that	that	WDT
cord-048487-kamvao4b	42	10	is	be	VBZ
cord-048487-kamvao4b	42	11	analogous	analogous	JJ
cord-048487-kamvao4b	42	12	to	to	IN
cord-048487-kamvao4b	42	13	the	the	DT
cord-048487-kamvao4b	42	14	hemagglutin	hemagglutin	NNP
cord-048487-kamvao4b	42	15	gene	gene	NN
cord-048487-kamvao4b	42	16	in	in	IN
cord-048487-kamvao4b	42	17	other	other	JJ
cord-048487-kamvao4b	42	18	subtypes	subtype	NNS
cord-048487-kamvao4b	42	19	[	[	-LRB-
cord-048487-kamvao4b	42	20	1	1	CD
cord-048487-kamvao4b	42	21	]	]	-RRB-
cord-048487-kamvao4b	42	22	.	.	.
cord-048487-kamvao4b	43	1	We	-PRON-	PRP
cord-048487-kamvao4b	43	2	hence	hence	RB
cord-048487-kamvao4b	43	3	refer	refer	VBP
cord-048487-kamvao4b	43	4	to	to	IN
cord-048487-kamvao4b	43	5	the	the	DT
cord-048487-kamvao4b	43	6	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	43	7	gene	gene	NN
cord-048487-kamvao4b	43	8	generally	generally	RB
cord-048487-kamvao4b	43	9	and	and	CC
cord-048487-kamvao4b	43	10	the	the	DT
cord-048487-kamvao4b	43	11	hemagglutininesterase	hemagglutininesterase	NNP
cord-048487-kamvao4b	43	12	gene	gene	NN
cord-048487-kamvao4b	43	13	when	when	WRB
cord-048487-kamvao4b	43	14	referring	refer	VBG
cord-048487-kamvao4b	43	15	specifically	specifically	RB
cord-048487-kamvao4b	43	16	to	to	IN
cord-048487-kamvao4b	43	17	the	the	DT
cord-048487-kamvao4b	43	18	subtype	subtype	NN
cord-048487-kamvao4b	43	19	C	c	NN
cord-048487-kamvao4b	43	20	sequences	sequence	NNS
cord-048487-kamvao4b	43	21	.	.	.
cord-048487-kamvao4b	44	1	We	-PRON-	PRP
cord-048487-kamvao4b	44	2	present	present	VBP
cord-048487-kamvao4b	44	3	a	a	DT
cord-048487-kamvao4b	44	4	simple	simple	JJ
cord-048487-kamvao4b	44	5	estimation	estimation	NN
cord-048487-kamvao4b	44	6	tool	tool	NN
cord-048487-kamvao4b	44	7	to	to	TO
cord-048487-kamvao4b	44	8	determine	determine	VB
cord-048487-kamvao4b	44	9	the	the	DT
cord-048487-kamvao4b	44	10	date	date	NN
cord-048487-kamvao4b	44	11	of	of	IN
cord-048487-kamvao4b	44	12	divergence	divergence	NN
cord-048487-kamvao4b	44	13	among	among	IN
cord-048487-kamvao4b	44	14	viral	viral	JJ
cord-048487-kamvao4b	44	15	subtypes	subtype	NNS
cord-048487-kamvao4b	44	16	that	that	WDT
cord-048487-kamvao4b	44	17	overcomes	overcome	VBZ
cord-048487-kamvao4b	44	18	the	the	DT
cord-048487-kamvao4b	44	19	difficulties	difficulty	NNS
cord-048487-kamvao4b	44	20	encountered	encounter	VBN
cord-048487-kamvao4b	44	21	with	with	IN
cord-048487-kamvao4b	44	22	use	use	NN
cord-048487-kamvao4b	44	23	of	of	IN
cord-048487-kamvao4b	44	24	the	the	DT
cord-048487-kamvao4b	44	25	MCA	MCA	NNP
cord-048487-kamvao4b	44	26	by	by	IN
cord-048487-kamvao4b	44	27	measuring	measure	VBG
cord-048487-kamvao4b	44	28	the	the	DT
cord-048487-kamvao4b	44	29	pairwise	pairwise	JJ
cord-048487-kamvao4b	44	30	rate	rate	NN
cord-048487-kamvao4b	44	31	of	of	IN
cord-048487-kamvao4b	44	32	substitution	substitution	NN
cord-048487-kamvao4b	44	33	between	between	IN
cord-048487-kamvao4b	44	34	taxa	taxon	NNS
cord-048487-kamvao4b	44	35	.	.	.
cord-048487-kamvao4b	45	1	Our	-PRON-	PRP$
cord-048487-kamvao4b	45	2	estimator	estimator	NN
cord-048487-kamvao4b	45	3	derives	derive	VBZ
cord-048487-kamvao4b	45	4	from	from	IN
cord-048487-kamvao4b	45	5	the	the	DT
cord-048487-kamvao4b	45	6	triplet	triplet	NN
cord-048487-kamvao4b	45	7	statistic	statistic	NN
cord-048487-kamvao4b	45	8	developed	develop	VBN
cord-048487-kamvao4b	45	9	in	in	IN
cord-048487-kamvao4b	45	10	[	[	-LRB-
cord-048487-kamvao4b	45	11	26	26	CD
cord-048487-kamvao4b	45	12	,	,	,
cord-048487-kamvao4b	45	13	22	22	CD
cord-048487-kamvao4b	45	14	,	,	,
cord-048487-kamvao4b	45	15	13	13	CD
cord-048487-kamvao4b	45	16	]	]	-RRB-
cord-048487-kamvao4b	45	17	,	,	,
cord-048487-kamvao4b	45	18	where	where	WRB
cord-048487-kamvao4b	45	19	each	each	DT
cord-048487-kamvao4b	45	20	sequence	sequence	NN
cord-048487-kamvao4b	45	21	member	member	NN
cord-048487-kamvao4b	45	22	of	of	IN
cord-048487-kamvao4b	45	23	the	the	DT
cord-048487-kamvao4b	45	24	triplet	triplet	NN
cord-048487-kamvao4b	45	25	draws	draw	VBZ
cord-048487-kamvao4b	45	26	from	from	IN
cord-048487-kamvao4b	45	27	a	a	DT
cord-048487-kamvao4b	45	28	different	different	JJ
cord-048487-kamvao4b	45	29	subtype	subtype	NN
cord-048487-kamvao4b	45	30	.	.	.
cord-048487-kamvao4b	46	1	In	in	IN
cord-048487-kamvao4b	46	2	this	this	DT
cord-048487-kamvao4b	46	3	manner	manner	NN
cord-048487-kamvao4b	46	4	,	,	,
cord-048487-kamvao4b	46	5	we	-PRON-	PRP
cord-048487-kamvao4b	46	6	generate	generate	VBP
cord-048487-kamvao4b	46	7	from	from	IN
cord-048487-kamvao4b	46	8	each	each	DT
cord-048487-kamvao4b	46	9	triplet	triplet	NN
cord-048487-kamvao4b	46	10	an	an	DT
cord-048487-kamvao4b	46	11	estimate	estimate	NN
cord-048487-kamvao4b	46	12	of	of	IN
cord-048487-kamvao4b	46	13	the	the	DT
cord-048487-kamvao4b	46	14	rate	rate	NN
cord-048487-kamvao4b	46	15	of	of	IN
cord-048487-kamvao4b	46	16	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	46	17	substitution	substitution	NN
cord-048487-kamvao4b	46	18	between	between	IN
cord-048487-kamvao4b	46	19	the	the	DT
cord-048487-kamvao4b	46	20	most	most	RBS
cord-048487-kamvao4b	46	21	recently	recently	RB
cord-048487-kamvao4b	46	22	diverged	diverge	VBN
cord-048487-kamvao4b	46	23	subtypes	subtype	NNS
cord-048487-kamvao4b	46	24	,	,	,
cord-048487-kamvao4b	46	25	and	and	CC
cord-048487-kamvao4b	46	26	consequently	consequently	RB
cord-048487-kamvao4b	46	27	provide	provide	VB
cord-048487-kamvao4b	46	28	an	an	DT
cord-048487-kamvao4b	46	29	estimate	estimate	NN
cord-048487-kamvao4b	46	30	of	of	IN
cord-048487-kamvao4b	46	31	the	the	DT
cord-048487-kamvao4b	46	32	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	46	33	.	.	.
cord-048487-kamvao4b	47	1	This	this	DT
cord-048487-kamvao4b	47	2	circumvents	circumvent	VBZ
cord-048487-kamvao4b	47	3	the	the	DT
cord-048487-kamvao4b	47	4	problems	problem	NNS
cord-048487-kamvao4b	47	5	posed	pose	VBN
cord-048487-kamvao4b	47	6	by	by	IN
cord-048487-kamvao4b	47	7	earlier	early	JJR
cord-048487-kamvao4b	47	8	methods	method	NNS
cord-048487-kamvao4b	47	9	by	by	IN
cord-048487-kamvao4b	47	10	directly	directly	RB
cord-048487-kamvao4b	47	11	estimating	estimate	VBG
cord-048487-kamvao4b	47	12	the	the	DT
cord-048487-kamvao4b	47	13	pairwise	pairwise	JJ
cord-048487-kamvao4b	47	14	rate	rate	NN
cord-048487-kamvao4b	47	15	of	of	IN
cord-048487-kamvao4b	47	16	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	47	17	substitution	substitution	NN
cord-048487-kamvao4b	47	18	over	over	IN
cord-048487-kamvao4b	47	19	the	the	DT
cord-048487-kamvao4b	47	20	set	set	NN
cord-048487-kamvao4b	47	21	of	of	IN
cord-048487-kamvao4b	47	22	pairs	pair	NNS
cord-048487-kamvao4b	47	23	of	of	IN
cord-048487-kamvao4b	47	24	sequences	sequence	NNS
cord-048487-kamvao4b	47	25	straddling	straddle	VBG
cord-048487-kamvao4b	47	26	the	the	DT
cord-048487-kamvao4b	47	27	subtype	subtype	NN
cord-048487-kamvao4b	47	28	divergence	divergence	NN
cord-048487-kamvao4b	47	29	without	without	IN
cord-048487-kamvao4b	47	30	any	any	DT
cord-048487-kamvao4b	47	31	further	further	JJ
cord-048487-kamvao4b	47	32	rate	rate	NN
cord-048487-kamvao4b	47	33	assumptions	assumption	NNS
cord-048487-kamvao4b	47	34	other	other	JJ
cord-048487-kamvao4b	47	35	than	than	IN
cord-048487-kamvao4b	47	36	the	the	DT
cord-048487-kamvao4b	47	37	existence	existence	NN
cord-048487-kamvao4b	47	38	of	of	IN
cord-048487-kamvao4b	47	39	a	a	DT
cord-048487-kamvao4b	47	40	mean	mean	NN
cord-048487-kamvao4b	47	41	.	.	.
cord-048487-kamvao4b	48	1	However	however	RB
cord-048487-kamvao4b	48	2	,	,	,
cord-048487-kamvao4b	48	3	this	this	DT
cord-048487-kamvao4b	48	4	method	method	NN
cord-048487-kamvao4b	48	5	is	be	VBZ
cord-048487-kamvao4b	48	6	only	only	RB
cord-048487-kamvao4b	48	7	capable	capable	JJ
cord-048487-kamvao4b	48	8	of	of	IN
cord-048487-kamvao4b	48	9	determining	determine	VBG
cord-048487-kamvao4b	48	10	the	the	DT
cord-048487-kamvao4b	48	11	rate	rate	NN
cord-048487-kamvao4b	48	12	between	between	IN
cord-048487-kamvao4b	48	13	two	two	CD
cord-048487-kamvao4b	48	14	subtypes	subtype	NNS
cord-048487-kamvao4b	48	15	where	where	WRB
cord-048487-kamvao4b	48	16	a	a	DT
cord-048487-kamvao4b	48	17	third	third	NN
cord-048487-kamvao4b	48	18	,	,	,
cord-048487-kamvao4b	48	19	more	more	RBR
cord-048487-kamvao4b	48	20	distantly	distantly	RB
cord-048487-kamvao4b	48	21	related	relate	VBN
cord-048487-kamvao4b	48	22	,	,	,
cord-048487-kamvao4b	48	23	subtype	subtype	NN
cord-048487-kamvao4b	48	24	functions	function	NNS
cord-048487-kamvao4b	48	25	as	as	IN
cord-048487-kamvao4b	48	26	an	an	DT
cord-048487-kamvao4b	48	27	outgroup	outgroup	NN
cord-048487-kamvao4b	48	28	.	.	.
cord-048487-kamvao4b	49	1	This	this	DT
cord-048487-kamvao4b	49	2	method	method	NN
cord-048487-kamvao4b	49	3	thus	thus	RB
cord-048487-kamvao4b	49	4	trades	trade	VBZ
cord-048487-kamvao4b	49	5	the	the	DT
cord-048487-kamvao4b	49	6	ad	ad	FW
cord-048487-kamvao4b	49	7	hoc	hoc	FW
cord-048487-kamvao4b	49	8	rate	rate	NN
cord-048487-kamvao4b	49	9	assumptions	assumption	NNS
cord-048487-kamvao4b	49	10	of	of	IN
cord-048487-kamvao4b	49	11	the	the	DT
cord-048487-kamvao4b	49	12	previous	previous	JJ
cord-048487-kamvao4b	49	13	methods	method	NNS
cord-048487-kamvao4b	49	14	with	with	IN
cord-048487-kamvao4b	49	15	two	two	CD
cord-048487-kamvao4b	49	16	implicit	implicit	JJ
cord-048487-kamvao4b	49	17	conditions	condition	NNS
cord-048487-kamvao4b	49	18	:	:	:
cord-048487-kamvao4b	50	1	(	(	-LRB-
cord-048487-kamvao4b	50	2	i	i	NN
cord-048487-kamvao4b	50	3	)	)	-RRB-
cord-048487-kamvao4b	50	4	that	that	IN
cord-048487-kamvao4b	50	5	subtypes	subtype	NNS
cord-048487-kamvao4b	50	6	have	have	VBP
cord-048487-kamvao4b	50	7	a	a	DT
cord-048487-kamvao4b	50	8	unique	unique	JJ
cord-048487-kamvao4b	50	9	divergence	divergence	NN
cord-048487-kamvao4b	50	10	and	and	CC
cord-048487-kamvao4b	50	11	(	(	-LRB-
cord-048487-kamvao4b	50	12	ii	ii	NN
cord-048487-kamvao4b	50	13	)	)	-RRB-
cord-048487-kamvao4b	51	1	a	a	DT
cord-048487-kamvao4b	51	2	third	third	JJ
cord-048487-kamvao4b	51	3	,	,	,
cord-048487-kamvao4b	51	4	comparable	comparable	JJ
cord-048487-kamvao4b	51	5	subtype	subtype	NN
cord-048487-kamvao4b	51	6	is	be	VBZ
cord-048487-kamvao4b	51	7	available	available	JJ
cord-048487-kamvao4b	51	8	to	to	TO
cord-048487-kamvao4b	51	9	serve	serve	VB
cord-048487-kamvao4b	51	10	as	as	IN
cord-048487-kamvao4b	51	11	an	an	DT
cord-048487-kamvao4b	51	12	outgroup	outgroup	NN
cord-048487-kamvao4b	51	13	.	.	.
cord-048487-kamvao4b	52	1	In	in	IN
cord-048487-kamvao4b	52	2	exchange	exchange	NN
cord-048487-kamvao4b	52	3	,	,	,
cord-048487-kamvao4b	52	4	we	-PRON-	PRP
cord-048487-kamvao4b	52	5	arrive	arrive	VBP
cord-048487-kamvao4b	52	6	at	at	IN
cord-048487-kamvao4b	52	7	a	a	DT
cord-048487-kamvao4b	52	8	precise	precise	JJ
cord-048487-kamvao4b	52	9	statistical	statistical	JJ
cord-048487-kamvao4b	52	10	measure	measure	NN
cord-048487-kamvao4b	52	11	of	of	IN
cord-048487-kamvao4b	52	12	the	the	DT
cord-048487-kamvao4b	52	13	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	52	14	that	that	WDT
cord-048487-kamvao4b	52	15	converges	converge	VBZ
cord-048487-kamvao4b	52	16	as	as	IN
cord-048487-kamvao4b	52	17	the	the	DT
cord-048487-kamvao4b	52	18	number	number	NN
cord-048487-kamvao4b	52	19	of	of	IN
cord-048487-kamvao4b	52	20	taxa	taxon	NNS
cord-048487-kamvao4b	52	21	increases	increase	NNS
cord-048487-kamvao4b	52	22	and	and	CC
cord-048487-kamvao4b	52	23	is	be	VBZ
cord-048487-kamvao4b	52	24	robust	robust	JJ
cord-048487-kamvao4b	52	25	to	to	IN
cord-048487-kamvao4b	52	26	the	the	DT
cord-048487-kamvao4b	52	27	balancing	balancing	NN
cord-048487-kamvao4b	52	28	of	of	IN
cord-048487-kamvao4b	52	29	the	the	DT
cord-048487-kamvao4b	52	30	numbers	number	NNS
cord-048487-kamvao4b	52	31	of	of	IN
cord-048487-kamvao4b	52	32	taxa	taxon	NNS
cord-048487-kamvao4b	52	33	between	between	IN
cord-048487-kamvao4b	52	34	different	different	JJ
cord-048487-kamvao4b	52	35	subtypes	subtype	NNS
cord-048487-kamvao4b	52	36	.	.	.
cord-048487-kamvao4b	53	1	We	-PRON-	PRP
cord-048487-kamvao4b	53	2	show	show	VBP
cord-048487-kamvao4b	53	3	that	that	IN
cord-048487-kamvao4b	53	4	applying	apply	VBG
cord-048487-kamvao4b	53	5	this	this	DT
cord-048487-kamvao4b	53	6	method	method	NN
cord-048487-kamvao4b	53	7	to	to	IN
cord-048487-kamvao4b	53	8	dating	date	VBG
cord-048487-kamvao4b	53	9	the	the	DT
cord-048487-kamvao4b	53	10	divergence	divergence	NN
cord-048487-kamvao4b	53	11	of	of	IN
cord-048487-kamvao4b	53	12	influenza	influenza	NN
cord-048487-kamvao4b	53	13	subtypes	subtype	NNS
cord-048487-kamvao4b	53	14	A	A	NNP
cord-048487-kamvao4b	53	15	-	-	:
cord-048487-kamvao4b	53	16	H3N2	H3N2	NNP
cord-048487-kamvao4b	53	17	and	and	CC
cord-048487-kamvao4b	53	18	B	B	NNP
cord-048487-kamvao4b	53	19	gives	give	VBZ
cord-048487-kamvao4b	53	20	a	a	DT
cord-048487-kamvao4b	53	21	time	time	NN
cord-048487-kamvao4b	53	22	of	of	IN
cord-048487-kamvao4b	53	23	diver	diver	NN
cord-048487-kamvao4b	53	24	-	-	HYPH
cord-048487-kamvao4b	53	25	gence	gence	NNP
cord-048487-kamvao4b	53	26	approximately	approximately	RB
cord-048487-kamvao4b	53	27	100	100	CD
cord-048487-kamvao4b	53	28	years	year	NNS
cord-048487-kamvao4b	53	29	before	before	IN
cord-048487-kamvao4b	53	30	present	present	JJ
cord-048487-kamvao4b	53	31	,	,	,
cord-048487-kamvao4b	53	32	substantially	substantially	RB
cord-048487-kamvao4b	53	33	more	more	RBR
cord-048487-kamvao4b	53	34	recent	recent	JJ
cord-048487-kamvao4b	53	35	than	than	IN
cord-048487-kamvao4b	53	36	previous	previous	JJ
cord-048487-kamvao4b	53	37	estimates	estimate	NNS
cord-048487-kamvao4b	53	38	.	.	.
cord-048487-kamvao4b	54	1	To	to	TO
cord-048487-kamvao4b	54	2	calculate	calculate	VB
cord-048487-kamvao4b	54	3	the	the	DT
cord-048487-kamvao4b	54	4	rate	rate	NN
cord-048487-kamvao4b	54	5	of	of	IN
cord-048487-kamvao4b	54	6	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	54	7	substitution	substitution	NN
cord-048487-kamvao4b	54	8	,	,	,
cord-048487-kamvao4b	54	9	we	-PRON-	PRP
cord-048487-kamvao4b	54	10	require	require	VBP
cord-048487-kamvao4b	54	11	a	a	DT
cord-048487-kamvao4b	54	12	measurement	measurement	NN
cord-048487-kamvao4b	54	13	of	of	IN
cord-048487-kamvao4b	54	14	the	the	DT
cord-048487-kamvao4b	54	15	number	number	NN
cord-048487-kamvao4b	54	16	of	of	IN
cord-048487-kamvao4b	54	17	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	54	18	substitutions	substitution	NNS
cord-048487-kamvao4b	54	19	occurring	occur	VBG
cord-048487-kamvao4b	54	20	in	in	IN
cord-048487-kamvao4b	54	21	a	a	DT
cord-048487-kamvao4b	54	22	given	give	VBN
cord-048487-kamvao4b	54	23	time	time	NN
cord-048487-kamvao4b	54	24	interval	interval	NN
cord-048487-kamvao4b	54	25	.	.	.
cord-048487-kamvao4b	55	1	Starting	start	VBG
cord-048487-kamvao4b	55	2	from	from	IN
cord-048487-kamvao4b	55	3	a	a	DT
cord-048487-kamvao4b	55	4	given	give	VBN
cord-048487-kamvao4b	55	5	set	set	NN
cord-048487-kamvao4b	55	6	of	of	IN
cord-048487-kamvao4b	55	7	aligned	align	VBN
cord-048487-kamvao4b	55	8	sequences	sequence	NNS
cord-048487-kamvao4b	55	9	{	{	-LRB-
cord-048487-kamvao4b	55	10	s	s	NN
cord-048487-kamvao4b	55	11	1	1	CD
cord-048487-kamvao4b	55	12	,	,	,
cord-048487-kamvao4b	55	13	...	...	NFP
cord-048487-kamvao4b	55	14	,	,	,
cord-048487-kamvao4b	55	15	s	s	NN
cord-048487-kamvao4b	55	16	n	n	NN
cord-048487-kamvao4b	55	17	}	}	-RRB-
cord-048487-kamvao4b	55	18	for	for	IN
cord-048487-kamvao4b	55	19	n	n	CD
cord-048487-kamvao4b	55	20	taxa	taxon	NNS
cord-048487-kamvao4b	55	21	,	,	,
cord-048487-kamvao4b	55	22	we	-PRON-	PRP
cord-048487-kamvao4b	55	23	define	define	VBP
cord-048487-kamvao4b	55	24	the	the	DT
cord-048487-kamvao4b	55	25	pairwise	pairwise	JJ
cord-048487-kamvao4b	55	26	distance	distance	NN
cord-048487-kamvao4b	55	27	in	in	IN
cord-048487-kamvao4b	55	28	number	number	NN
cord-048487-kamvao4b	55	29	of	of	IN
cord-048487-kamvao4b	55	30	substitutions	substitution	NNS
cord-048487-kamvao4b	55	31	to	to	TO
cord-048487-kamvao4b	55	32	be	be	VB
cord-048487-kamvao4b	55	33	the	the	DT
cord-048487-kamvao4b	55	34	estimates	estimate	NNS
cord-048487-kamvao4b	55	35	{	{	-LRB-
cord-048487-kamvao4b	55	36	K	K	NNP
cord-048487-kamvao4b	55	37	ij	ij	NNP
cord-048487-kamvao4b	55	38	}	}	-RRB-
cord-048487-kamvao4b	55	39	under	under	IN
cord-048487-kamvao4b	55	40	a	a	DT
cord-048487-kamvao4b	55	41	given	give	VBN
cord-048487-kamvao4b	55	42	model	model	NN
cord-048487-kamvao4b	55	43	of	of	IN
cord-048487-kamvao4b	55	44	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	55	45	substitution	substitution	NN
cord-048487-kamvao4b	55	46	.	.	.
cord-048487-kamvao4b	56	1	Naturally	naturally	RB
cord-048487-kamvao4b	56	2	the	the	DT
cord-048487-kamvao4b	56	3	unobservable	unobservable	JJ
cord-048487-kamvao4b	56	4	true	true	JJ
cord-048487-kamvao4b	56	5	values	value	NNS
cord-048487-kamvao4b	56	6	{	{	-LRB-
cord-048487-kamvao4b	56	7	D	d	NN
cord-048487-kamvao4b	56	8	ij	ij	NN
cord-048487-kamvao4b	56	9	}	}	-RRB-
cord-048487-kamvao4b	56	10	of	of	IN
cord-048487-kamvao4b	56	11	the	the	DT
cord-048487-kamvao4b	56	12	pairwise	pairwise	JJ
cord-048487-kamvao4b	56	13	distances	distance	NNS
cord-048487-kamvao4b	56	14	differ	differ	VBP
cord-048487-kamvao4b	56	15	from	from	IN
cord-048487-kamvao4b	56	16	their	-PRON-	PRP$
cord-048487-kamvao4b	56	17	estimates	estimate	NNS
cord-048487-kamvao4b	56	18	{	{	-LRB-
cord-048487-kamvao4b	56	19	K	K	NNP
cord-048487-kamvao4b	56	20	ij	ij	NNP
cord-048487-kamvao4b	56	21	}	}	-RRB-
cord-048487-kamvao4b	56	22	.	.	.
cord-048487-kamvao4b	57	1	To	to	TO
cord-048487-kamvao4b	57	2	understand	understand	VB
cord-048487-kamvao4b	57	3	this	this	DT
cord-048487-kamvao4b	57	4	difference	difference	NN
cord-048487-kamvao4b	57	5	,	,	,
cord-048487-kamvao4b	57	6	we	-PRON-	PRP
cord-048487-kamvao4b	57	7	associate	associate	VBP
cord-048487-kamvao4b	57	8	each	each	DT
cord-048487-kamvao4b	57	9	D	d	NN
cord-048487-kamvao4b	57	10	ij	ij	NN
cord-048487-kamvao4b	57	11	with	with	IN
cord-048487-kamvao4b	57	12	an	an	DT
cord-048487-kamvao4b	57	13	error	error	NN
cord-048487-kamvao4b	57	14	ε	ε	NN
cord-048487-kamvao4b	57	15	ij	ij	NNP
cord-048487-kamvao4b	57	16	and	and	CC
cord-048487-kamvao4b	57	17	assume	assume	VB
cord-048487-kamvao4b	57	18	that	that	IN
cord-048487-kamvao4b	57	19	ε	ε	NNP
cord-048487-kamvao4b	57	20	ij	ij	NNP
cord-048487-kamvao4b	57	21	tends	tend	VBZ
cord-048487-kamvao4b	57	22	to	to	IN
cord-048487-kamvao4b	57	23	zero	zero	CD
cord-048487-kamvao4b	57	24	as	as	IN
cord-048487-kamvao4b	57	25	sequence	sequence	NN
cord-048487-kamvao4b	57	26	lengths	length	NNS
cord-048487-kamvao4b	57	27	increase	increase	VBP
cord-048487-kamvao4b	57	28	without	without	IN
cord-048487-kamvao4b	57	29	bound	bind	VBN
cord-048487-kamvao4b	57	30	.	.	.
cord-048487-kamvao4b	58	1	We	-PRON-	PRP
cord-048487-kamvao4b	58	2	further	further	RB
cord-048487-kamvao4b	58	3	assume	assume	VBP
cord-048487-kamvao4b	58	4	that	that	IN
cord-048487-kamvao4b	58	5	the	the	DT
cord-048487-kamvao4b	58	6	covariance	covariance	NN
cord-048487-kamvao4b	58	7	between	between	IN
cord-048487-kamvao4b	58	8	errors	error	NNS
cord-048487-kamvao4b	58	9	,	,	,
cord-048487-kamvao4b	58	10	cov(ε	cov(ε	NNP
cord-048487-kamvao4b	58	11	ij	ij	NNP
cord-048487-kamvao4b	58	12	;	;	:
cord-048487-kamvao4b	58	13	ε	ε	NNP
cord-048487-kamvao4b	58	14	mn	mn	NNP
cord-048487-kamvao4b	58	15	)	)	-RRB-
cord-048487-kamvao4b	58	16	,	,	,
cord-048487-kamvao4b	58	17	is	be	VBZ
cord-048487-kamvao4b	58	18	bounded	bound	VBN
cord-048487-kamvao4b	58	19	and	and	CC
cord-048487-kamvao4b	58	20	known	know	VBN
cord-048487-kamvao4b	58	21	.	.	.
cord-048487-kamvao4b	59	1	For	for	IN
cord-048487-kamvao4b	59	2	time	time	NN
cord-048487-kamvao4b	59	3	measurements	measurement	NNS
cord-048487-kamvao4b	59	4	,	,	,
cord-048487-kamvao4b	59	5	we	-PRON-	PRP
cord-048487-kamvao4b	59	6	assume	assume	VBP
cord-048487-kamvao4b	59	7	that	that	IN
cord-048487-kamvao4b	59	8	each	each	DT
cord-048487-kamvao4b	59	9	sequence	sequence	NN
cord-048487-kamvao4b	59	10	is	be	VBZ
cord-048487-kamvao4b	59	11	labeled	label	VBN
cord-048487-kamvao4b	59	12	by	by	IN
cord-048487-kamvao4b	59	13	a	a	DT
cord-048487-kamvao4b	59	14	sampling	sampling	NN
cord-048487-kamvao4b	59	15	time	time	NN
cord-048487-kamvao4b	59	16	t	t	NNP
cord-048487-kamvao4b	59	17	i	i	PRP
cord-048487-kamvao4b	59	18	given	give	VBN
cord-048487-kamvao4b	59	19	in	in	IN
cord-048487-kamvao4b	59	20	consistent	consistent	JJ
cord-048487-kamvao4b	59	21	units	unit	NNS
cord-048487-kamvao4b	59	22	.	.	.
cord-048487-kamvao4b	60	1	Since	since	IN
cord-048487-kamvao4b	60	2	we	-PRON-	PRP
cord-048487-kamvao4b	60	3	know	know	VBP
cord-048487-kamvao4b	60	4	only	only	RB
cord-048487-kamvao4b	60	5	the	the	DT
cord-048487-kamvao4b	60	6	sampling	sampling	NN
cord-048487-kamvao4b	60	7	time	time	NN
cord-048487-kamvao4b	60	8	of	of	IN
cord-048487-kamvao4b	60	9	a	a	DT
cord-048487-kamvao4b	60	10	given	give	VBN
cord-048487-kamvao4b	60	11	sample	sample	NN
cord-048487-kamvao4b	60	12	up	up	RP
cord-048487-kamvao4b	60	13	to	to	IN
cord-048487-kamvao4b	60	14	the	the	DT
cord-048487-kamvao4b	60	15	unit	unit	NN
cord-048487-kamvao4b	60	16	of	of	IN
cord-048487-kamvao4b	60	17	time	time	NN
cord-048487-kamvao4b	60	18	reported	report	VBN
cord-048487-kamvao4b	60	19	(	(	-LRB-
cord-048487-kamvao4b	60	20	day	day	NN
cord-048487-kamvao4b	60	21	,	,	,
cord-048487-kamvao4b	60	22	month	month	NN
cord-048487-kamvao4b	60	23	,	,	,
cord-048487-kamvao4b	60	24	year	year	NN
cord-048487-kamvao4b	60	25	)	)	-RRB-
cord-048487-kamvao4b	60	26	we	-PRON-	PRP
cord-048487-kamvao4b	60	27	posit	posit	VBP
cord-048487-kamvao4b	60	28	an	an	DT
cord-048487-kamvao4b	60	29	uniform	uniform	JJ
cord-048487-kamvao4b	60	30	error	error	NN
cord-048487-kamvao4b	61	1	ν	ν	NNP
cord-048487-kamvao4b	61	2	i	i	NN
cord-048487-kamvao4b	61	3	~	~	NFP
cord-048487-kamvao4b	61	4	U	u	NN
cord-048487-kamvao4b	61	5	[	[	-LRB-
cord-048487-kamvao4b	61	6	0	0	NFP
cord-048487-kamvao4b	61	7	,	,	,
cord-048487-kamvao4b	61	8	1	1	CD
cord-048487-kamvao4b	61	9	]	]	-RRB-
cord-048487-kamvao4b	61	10	underlying	underlie	VBG
cord-048487-kamvao4b	61	11	each	each	DT
cord-048487-kamvao4b	61	12	t	t	NN
cord-048487-kamvao4b	61	13	i	i	PRP
cord-048487-kamvao4b	61	14	over	over	IN
cord-048487-kamvao4b	61	15	the	the	DT
cord-048487-kamvao4b	61	16	unit	unit	NN
cord-048487-kamvao4b	61	17	sampling	sampling	NN
cord-048487-kamvao4b	61	18	interval	interval	NN
cord-048487-kamvao4b	61	19	.	.	.
cord-048487-kamvao4b	62	1	To	to	TO
cord-048487-kamvao4b	62	2	complete	complete	VB
cord-048487-kamvao4b	62	3	the	the	DT
cord-048487-kamvao4b	62	4	error	error	NN
cord-048487-kamvao4b	62	5	structure	structure	NN
cord-048487-kamvao4b	62	6	specification	specification	NN
cord-048487-kamvao4b	62	7	we	-PRON-	PRP
cord-048487-kamvao4b	62	8	force	force	VBP
cord-048487-kamvao4b	62	9	the	the	DT
cord-048487-kamvao4b	62	10	two	two	CD
cord-048487-kamvao4b	62	11	forms	form	NNS
cord-048487-kamvao4b	62	12	of	of	IN
cord-048487-kamvao4b	62	13	error	error	NN
cord-048487-kamvao4b	62	14	(	(	-LRB-
cord-048487-kamvao4b	62	15	ν	ν	NNP
cord-048487-kamvao4b	62	16	i	i	NNP
cord-048487-kamvao4b	62	17	and	and	CC
cord-048487-kamvao4b	62	18	ε	ε	NNP
cord-048487-kamvao4b	62	19	ij	ij	NNP
cord-048487-kamvao4b	62	20	)	)	-RRB-
cord-048487-kamvao4b	62	21	to	to	TO
cord-048487-kamvao4b	62	22	be	be	VB
cord-048487-kamvao4b	62	23	independent	independent	JJ
cord-048487-kamvao4b	62	24	.	.	.
cord-048487-kamvao4b	63	1	Finally	finally	RB
cord-048487-kamvao4b	63	2	,	,	,
cord-048487-kamvao4b	63	3	for	for	IN
cord-048487-kamvao4b	63	4	a	a	DT
cord-048487-kamvao4b	63	5	set	set	NN
cord-048487-kamvao4b	63	6	of	of	IN
cord-048487-kamvao4b	63	7	three	three	CD
cord-048487-kamvao4b	63	8	sequences	sequence	NNS
cord-048487-kamvao4b	63	9	(	(	-LRB-
cord-048487-kamvao4b	63	10	s	s	NNP
cord-048487-kamvao4b	63	11	i	i	NNP
cord-048487-kamvao4b	63	12	,	,	,
cord-048487-kamvao4b	63	13	s	s	NNP
cord-048487-kamvao4b	63	14	j	j	NNP
cord-048487-kamvao4b	63	15	,	,	,
cord-048487-kamvao4b	63	16	s	s	NNP
cord-048487-kamvao4b	63	17	k	k	NNP
cord-048487-kamvao4b	63	18	)	)	-RRB-
cord-048487-kamvao4b	63	19	and	and	CC
cord-048487-kamvao4b	63	20	their	-PRON-	PRP$
cord-048487-kamvao4b	63	21	associated	associate	VBN
cord-048487-kamvao4b	63	22	pairwise	pairwise	JJ
cord-048487-kamvao4b	63	23	distances	distance	NNS
cord-048487-kamvao4b	63	24	,	,	,
cord-048487-kamvao4b	63	25	we	-PRON-	PRP
cord-048487-kamvao4b	63	26	enforce	enforce	VBP
cord-048487-kamvao4b	63	27	a	a	DT
cord-048487-kamvao4b	63	28	fixed	fix	VBN
cord-048487-kamvao4b	63	29	topology	topology	NN
cord-048487-kamvao4b	63	30	among	among	IN
cord-048487-kamvao4b	63	31	sequences	sequence	NNS
cord-048487-kamvao4b	63	32	,	,	,
cord-048487-kamvao4b	63	33	as	as	IN
cord-048487-kamvao4b	63	34	shown	show	VBN
cord-048487-kamvao4b	63	35	in	in	IN
cord-048487-kamvao4b	63	36	Figure	figure	NN
cord-048487-kamvao4b	63	37	1	1	CD
cord-048487-kamvao4b	63	38	,	,	,
cord-048487-kamvao4b	63	39	via	via	IN
cord-048487-kamvao4b	63	40	methods	method	NNS
cord-048487-kamvao4b	63	41	outlined	outline	VBN
cord-048487-kamvao4b	63	42	in	in	IN
cord-048487-kamvao4b	63	43	[	[	-LRB-
cord-048487-kamvao4b	63	44	26	26	CD
cord-048487-kamvao4b	63	45	]	]	-RRB-
cord-048487-kamvao4b	63	46	.	.	.
cord-048487-kamvao4b	64	1	We	-PRON-	PRP
cord-048487-kamvao4b	64	2	augment	augment	VBP
cord-048487-kamvao4b	64	3	the	the	DT
cord-048487-kamvao4b	64	4	topology	topology	NN
cord-048487-kamvao4b	64	5	with	with	IN
cord-048487-kamvao4b	64	6	the	the	DT
cord-048487-kamvao4b	64	7	observed	observed	JJ
cord-048487-kamvao4b	64	8	sampling	sampling	NN
cord-048487-kamvao4b	64	9	times	time	NNS
cord-048487-kamvao4b	64	10	of	of	IN
cord-048487-kamvao4b	64	11	the	the	DT
cord-048487-kamvao4b	64	12	three	three	CD
cord-048487-kamvao4b	64	13	sequences	sequence	NNS
cord-048487-kamvao4b	64	14	,	,	,
cord-048487-kamvao4b	64	15	α	α	NN
cord-048487-kamvao4b	64	16	,	,	,
cord-048487-kamvao4b	64	17	the	the	DT
cord-048487-kamvao4b	64	18	divergence	divergence	NN
cord-048487-kamvao4b	64	19	time	time	NN
cord-048487-kamvao4b	64	20	between	between	IN
cord-048487-kamvao4b	64	21	the	the	DT
cord-048487-kamvao4b	64	22	two	two	CD
cord-048487-kamvao4b	64	23	sequences	sequence	NNS
cord-048487-kamvao4b	64	24	of	of	IN
cord-048487-kamvao4b	64	25	interest	interest	NN
cord-048487-kamvao4b	64	26	and	and	CC
cord-048487-kamvao4b	64	27	β	β	NN
cord-048487-kamvao4b	64	28	,	,	,
cord-048487-kamvao4b	64	29	the	the	DT
cord-048487-kamvao4b	64	30	divergence	divergence	NN
cord-048487-kamvao4b	64	31	time	time	NN
cord-048487-kamvao4b	64	32	of	of	IN
cord-048487-kamvao4b	64	33	all	all	DT
cord-048487-kamvao4b	64	34	sequences	sequence	NNS
cord-048487-kamvao4b	64	35	.	.	.
cord-048487-kamvao4b	65	1	When	when	WRB
cord-048487-kamvao4b	65	2	necessary	necessary	JJ
cord-048487-kamvao4b	65	3	for	for	IN
cord-048487-kamvao4b	65	4	clarity	clarity	NN
cord-048487-kamvao4b	65	5	,	,	,
cord-048487-kamvao4b	65	6	we	-PRON-	PRP
cord-048487-kamvao4b	65	7	write	write	VBP
cord-048487-kamvao4b	65	8	α	α	NNP
cord-048487-kamvao4b	65	9	ij	ij	NN
cord-048487-kamvao4b	65	10	to	to	TO
cord-048487-kamvao4b	65	11	indicate	indicate	VB
cord-048487-kamvao4b	65	12	the	the	DT
cord-048487-kamvao4b	65	13	true	true	JJ
cord-048487-kamvao4b	65	14	time	time	NN
cord-048487-kamvao4b	65	15	of	of	IN
cord-048487-kamvao4b	65	16	divergence	divergence	NN
cord-048487-kamvao4b	65	17	between	between	IN
cord-048487-kamvao4b	65	18	sequences	sequence	NNS
cord-048487-kamvao4b	66	1	i	i	PRP
cord-048487-kamvao4b	66	2	and	and	CC
cord-048487-kamvao4b	66	3	j.	j.	NNP
cord-048487-kamvao4b	66	4	Under	under	IN
cord-048487-kamvao4b	66	5	our	-PRON-	PRP$
cord-048487-kamvao4b	66	6	triplet	triplet	NN
cord-048487-kamvao4b	66	7	method	method	NN
cord-048487-kamvao4b	66	8	,	,	,
cord-048487-kamvao4b	66	9	we	-PRON-	PRP
cord-048487-kamvao4b	66	10	aim	aim	VBP
cord-048487-kamvao4b	66	11	to	to	TO
cord-048487-kamvao4b	66	12	estimate	estimate	VB
cord-048487-kamvao4b	66	13	the	the	DT
cord-048487-kamvao4b	66	14	true	true	JJ
cord-048487-kamvao4b	66	15	rate	rate	NN
cord-048487-kamvao4b	66	16	of	of	IN
cord-048487-kamvao4b	66	17	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	66	18	substitution	substitution	NN
cord-048487-kamvao4b	66	19	,	,	,
cord-048487-kamvao4b	66	20	p	p	NN
cord-048487-kamvao4b	66	21	ij	ij	NN
cord-048487-kamvao4b	66	22	,	,	,
cord-048487-kamvao4b	66	23	between	between	IN
cord-048487-kamvao4b	66	24	sequences	sequence	NNS
cord-048487-kamvao4b	66	25	s	s	NNP
cord-048487-kamvao4b	66	26	i	i	NNP
cord-048487-kamvao4b	66	27	and	and	CC
cord-048487-kamvao4b	66	28	s	s	NNP
cord-048487-kamvao4b	66	29	j	j	NNP
cord-048487-kamvao4b	66	30	with	with	IN
cord-048487-kamvao4b	66	31	an	an	DT
cord-048487-kamvao4b	66	32	unobserved	unobserved	JJ
cord-048487-kamvao4b	66	33	error	error	NN
cord-048487-kamvao4b	66	34	δ	δ	NN
cord-048487-kamvao4b	66	35	ij	ij	NN
cord-048487-kamvao4b	66	36	.	.	.
cord-048487-kamvao4b	67	1	With	with	IN
cord-048487-kamvao4b	67	2	respect	respect	NN
cord-048487-kamvao4b	67	3	to	to	IN
cord-048487-kamvao4b	67	4	outgroup	outgroup	NN
cord-048487-kamvao4b	67	5	sequence	sequence	NN
cord-048487-kamvao4b	68	1	k	k	NNP
cord-048487-kamvao4b	68	2	,	,	,
cord-048487-kamvao4b	68	3	an	an	DT
cord-048487-kamvao4b	68	4	unbiased	unbiased	JJ
cord-048487-kamvao4b	68	5	estimate	estimate	NN
cord-048487-kamvao4b	68	6	is	be	VBZ
cord-048487-kamvao4b	68	7	where	where	WRB
cord-048487-kamvao4b	68	8	the	the	DT
cord-048487-kamvao4b	68	9	factor	factor	NN
cord-048487-kamvao4b	68	10	corrects	correct	VBZ
cord-048487-kamvao4b	68	11	for	for	IN
cord-048487-kamvao4b	68	12	bias	bias	NN
cord-048487-kamvao4b	68	13	resulting	result	VBG
cord-048487-kamvao4b	68	14	from	from	IN
cord-048487-kamvao4b	68	15	the	the	DT
cord-048487-kamvao4b	68	16	time	time	NN
cord-048487-kamvao4b	68	17	sampling	sampling	NN
cord-048487-kamvao4b	68	18	error	error	NN
cord-048487-kamvao4b	68	19	structure	structure	NN
cord-048487-kamvao4b	68	20	(	(	-LRB-
cord-048487-kamvao4b	68	21	see	see	VB
cord-048487-kamvao4b	68	22	Appendix	Appendix	NNP
cord-048487-kamvao4b	68	23	for	for	IN
cord-048487-kamvao4b	68	24	derivation	derivation	NN
cord-048487-kamvao4b	68	25	)	)	-RRB-
cord-048487-kamvao4b	68	26	.	.	.
cord-048487-kamvao4b	69	1	We	-PRON-	PRP
cord-048487-kamvao4b	69	2	superscript	superscript	VBP
cord-048487-kamvao4b	69	3	to	to	TO
cord-048487-kamvao4b	69	4	denote	denote	VB
cord-048487-kamvao4b	69	5	its	-PRON-	PRP$
cord-048487-kamvao4b	69	6	weak	weak	JJ
cord-048487-kamvao4b	69	7	dependence	dependence	NN
cord-048487-kamvao4b	69	8	on	on	IN
cord-048487-kamvao4b	69	9	outgroup	outgroup	NN
cord-048487-kamvao4b	69	10	sequence	sequence	NN
cord-048487-kamvao4b	69	11	k.	k.	NNP
cord-048487-kamvao4b	69	12	Dependence	Dependence	NNP
cord-048487-kamvao4b	69	13	is	be	VBZ
cord-048487-kamvao4b	69	14	weak	weak	JJ
cord-048487-kamvao4b	69	15	as	as	IN
cord-048487-kamvao4b	69	16	the	the	DT
cord-048487-kamvao4b	69	17	path	path	NN
cord-048487-kamvao4b	69	18	of	of	IN
cord-048487-kamvao4b	69	19	evolution	evolution	NN
cord-048487-kamvao4b	69	20	from	from	IN
cord-048487-kamvao4b	69	21	t	t	NNP
cord-048487-kamvao4b	69	22	k	k	NNP
cord-048487-kamvao4b	69	23	to	to	IN
cord-048487-kamvao4b	69	24	α	α	NNP
cord-048487-kamvao4b	69	25	is	be	VBZ
cord-048487-kamvao4b	69	26	shared	share	VBN
cord-048487-kamvao4b	69	27	between	between	IN
cord-048487-kamvao4b	69	28	the	the	DT
cord-048487-kamvao4b	69	29	paths	path	NNS
cord-048487-kamvao4b	69	30	from	from	IN
cord-048487-kamvao4b	69	31	sequence	sequence	NN
cord-048487-kamvao4b	69	32	k	k	NN
cord-048487-kamvao4b	69	33	to	to	IN
cord-048487-kamvao4b	69	34	both	both	DT
cord-048487-kamvao4b	69	35	sequence	sequence	NN
cord-048487-kamvao4b	69	36	i	i	PRP
cord-048487-kamvao4b	69	37	and	and	CC
cord-048487-kamvao4b	69	38	sequence	sequence	NN
cord-048487-kamvao4b	69	39	j	j	NNP
cord-048487-kamvao4b	69	40	and	and	CC
cord-048487-kamvao4b	69	41	hence	hence	RB
cord-048487-kamvao4b	69	42	largely	largely	RB
cord-048487-kamvao4b	69	43	cancels	cancel	VBZ
cord-048487-kamvao4b	69	44	out	out	RP
cord-048487-kamvao4b	69	45	in	in	IN
cord-048487-kamvao4b	69	46	Equation	equation	NN
cord-048487-kamvao4b	69	47	1	1	CD
cord-048487-kamvao4b	69	48	.	.	.
cord-048487-kamvao4b	70	1	We	-PRON-	PRP
cord-048487-kamvao4b	70	2	make	make	VBP
cord-048487-kamvao4b	70	3	this	this	DT
cord-048487-kamvao4b	70	4	transparent	transparent	JJ
cord-048487-kamvao4b	70	5	in	in	IN
cord-048487-kamvao4b	70	6	the	the	DT
cord-048487-kamvao4b	70	7	following	follow	VBG
cord-048487-kamvao4b	70	8	derivation	derivation	NN
cord-048487-kamvao4b	70	9	.	.	.
cord-048487-kamvao4b	71	1	For	for	IN
cord-048487-kamvao4b	71	2	brevity	brevity	NN
cord-048487-kamvao4b	71	3	,	,	,
cord-048487-kamvao4b	71	4	we	-PRON-	PRP
cord-048487-kamvao4b	71	5	consider	consider	VBP
cord-048487-kamvao4b	71	6	only	only	RB
cord-048487-kamvao4b	71	7	unobservable	unobservable	JJ
cord-048487-kamvao4b	71	8	true	true	JJ
cord-048487-kamvao4b	71	9	values	value	NNS
cord-048487-kamvao4b	71	10	,	,	,
cord-048487-kamvao4b	71	11	ignoring	ignore	VBG
cord-048487-kamvao4b	71	12	error	error	NN
cord-048487-kamvao4b	71	13	terms	term	NNS
cord-048487-kamvao4b	71	14	.	.	.
cord-048487-kamvao4b	72	1	Let	let	VB
cord-048487-kamvao4b	72	2	u	u	PRP
cord-048487-kamvao4b	72	3	be	be	VB
cord-048487-kamvao4b	72	4	the	the	DT
cord-048487-kamvao4b	72	5	location	location	NN
cord-048487-kamvao4b	72	6	on	on	IN
cord-048487-kamvao4b	72	7	the	the	DT
cord-048487-kamvao4b	72	8	triplet	triplet	NN
cord-048487-kamvao4b	72	9	in	in	IN
cord-048487-kamvao4b	72	10	Figure	figure	NN
cord-048487-kamvao4b	72	11	1	1	CD
cord-048487-kamvao4b	72	12	corresponding	correspond	VBG
cord-048487-kamvao4b	72	13	to	to	IN
cord-048487-kamvao4b	72	14	time	time	NN
cord-048487-kamvao4b	72	15	α	α	NN
cord-048487-kamvao4b	72	16	and	and	CC
cord-048487-kamvao4b	72	17	let	let	VB
cord-048487-kamvao4b	72	18	p	p	NN
cord-048487-kamvao4b	72	19	xy	xy	PRP
cord-048487-kamvao4b	72	20	be	be	VB
cord-048487-kamvao4b	72	21	the	the	DT
cord-048487-kamvao4b	72	22	true	true	JJ
cord-048487-kamvao4b	72	23	rate	rate	NN
cord-048487-kamvao4b	72	24	along	along	IN
cord-048487-kamvao4b	72	25	the	the	DT
cord-048487-kamvao4b	72	26	path	path	NN
cord-048487-kamvao4b	72	27	connecting	connect	VBG
cord-048487-kamvao4b	72	28	locations	location	NNS
cord-048487-kamvao4b	73	1	x	x	LS
cord-048487-kamvao4b	74	1	and	and	CC
cord-048487-kamvao4b	74	2	y.	y.	NNP
cord-048487-kamvao4b	75	1	Then	then	RB
cord-048487-kamvao4b	75	2	,	,	,
cord-048487-kamvao4b	75	3	as	as	IN
cord-048487-kamvao4b	75	4	distance	distance	NN
cord-048487-kamvao4b	75	5	is	be	VBZ
cord-048487-kamvao4b	75	6	rate	rate	NN
cord-048487-kamvao4b	75	7	multiplied	multiply	VBN
cord-048487-kamvao4b	75	8	by	by	IN
cord-048487-kamvao4b	75	9	time	time	NN
cord-048487-kamvao4b	75	10	,	,	,
cord-048487-kamvao4b	75	11	we	-PRON-	PRP
cord-048487-kamvao4b	75	12	have	have	VBP
cord-048487-kamvao4b	75	13	Subtracting	subtract	VBG
cord-048487-kamvao4b	75	14	the	the	DT
cord-048487-kamvao4b	75	15	first	first	JJ
cord-048487-kamvao4b	75	16	equation	equation	NN
cord-048487-kamvao4b	75	17	from	from	IN
cord-048487-kamvao4b	75	18	the	the	DT
cord-048487-kamvao4b	75	19	second	second	JJ
cord-048487-kamvao4b	75	20	equation	equation	NN
cord-048487-kamvao4b	75	21	,	,	,
cord-048487-kamvao4b	75	22	which	which	WDT
cord-048487-kamvao4b	75	23	is	be	VBZ
cord-048487-kamvao4b	75	24	equivalent	equivalent	JJ
cord-048487-kamvao4b	75	25	to	to	IN
cord-048487-kamvao4b	75	26	Equation	equation	NN
cord-048487-kamvao4b	75	27	1	1	CD
cord-048487-kamvao4b	75	28	.	.	.
cord-048487-kamvao4b	76	1	This	this	DT
cord-048487-kamvao4b	76	2	derivation	derivation	NN
cord-048487-kamvao4b	76	3	makes	make	VBZ
cord-048487-kamvao4b	76	4	clear	clear	JJ
cord-048487-kamvao4b	76	5	that	that	IN
cord-048487-kamvao4b	76	6	the	the	DT
cord-048487-kamvao4b	76	7	estimator	estimator	NN
cord-048487-kamvao4b	76	8	(	(	-LRB-
cord-048487-kamvao4b	76	9	1	1	CD
cord-048487-kamvao4b	76	10	)	)	-RRB-
cord-048487-kamvao4b	76	11	measures	measure	VBZ
cord-048487-kamvao4b	76	12	the	the	DT
cord-048487-kamvao4b	76	13	rate	rate	NN
cord-048487-kamvao4b	76	14	along	along	IN
cord-048487-kamvao4b	76	15	the	the	DT
cord-048487-kamvao4b	76	16	path	path	NN
cord-048487-kamvao4b	76	17	from	from	IN
cord-048487-kamvao4b	76	18	sequence	sequence	NN
cord-048487-kamvao4b	76	19	i	i	PRP
cord-048487-kamvao4b	76	20	to	to	TO
cord-048487-kamvao4b	76	21	sequence	sequence	VB
cord-048487-kamvao4b	76	22	j	j	NNP
cord-048487-kamvao4b	76	23	,	,	,
cord-048487-kamvao4b	76	24	with	with	IN
cord-048487-kamvao4b	76	25	only	only	JJ
cord-048487-kamvao4b	76	26	incidental	incidental	JJ
cord-048487-kamvao4b	76	27	dependence	dependence	NN
cord-048487-kamvao4b	76	28	on	on	IN
cord-048487-kamvao4b	76	29	sequence	sequence	NN
cord-048487-kamvao4b	77	1	k.	k.	NNP
cord-048487-kamvao4b	78	1	The	the	DT
cord-048487-kamvao4b	78	2	variance	variance	NN
cord-048487-kamvao4b	78	3	for	for	IN
cord-048487-kamvao4b	78	4	the	the	DT
cord-048487-kamvao4b	78	5	estimator	estimator	NN
cord-048487-kamvao4b	78	6	(	(	-LRB-
cord-048487-kamvao4b	78	7	1	1	CD
cord-048487-kamvao4b	78	8	)	)	-RRB-
cord-048487-kamvao4b	78	9	is	be	VBZ
cord-048487-kamvao4b	78	10	well	well	RB
cord-048487-kamvao4b	78	11	approximated	approximate	VBN
cord-048487-kamvao4b	78	12	by	by	IN
cord-048487-kamvao4b	78	13	Further	further	RB
cord-048487-kamvao4b	78	14	,	,	,
cord-048487-kamvao4b	78	15	we	-PRON-	PRP
cord-048487-kamvao4b	78	16	can	can	MD
cord-048487-kamvao4b	78	17	estimate	estimate	VB
cord-048487-kamvao4b	78	18	the	the	DT
cord-048487-kamvao4b	78	19	time	time	NN
cord-048487-kamvao4b	78	20	of	of	IN
cord-048487-kamvao4b	78	21	subtype	subtype	NN
cord-048487-kamvao4b	78	22	divergence	divergence	NN
cord-048487-kamvao4b	78	23	α	α	NNP
cord-048487-kamvao4b	78	24	(	(	-LRB-
cord-048487-kamvao4b	78	25	Figure	figure	NN
cord-048487-kamvao4b	78	26	1	1	CD
cord-048487-kamvao4b	78	27	)	)	-RRB-
cord-048487-kamvao4b	78	28	between	between	IN
cord-048487-kamvao4b	78	29	sequences	sequence	NNS
cord-048487-kamvao4b	78	30	via	via	IN
cord-048487-kamvao4b	79	1	We	-PRON-	PRP
cord-048487-kamvao4b	79	2	note	note	VBP
cord-048487-kamvao4b	79	3	that	that	IN
cord-048487-kamvao4b	79	4	the	the	DT
cord-048487-kamvao4b	79	5	term	term	NN
cord-048487-kamvao4b	79	6	t	t	NN
cord-048487-kamvao4b	80	1	i	i	PRP
cord-048487-kamvao4b	80	2	+	+	CC
cord-048487-kamvao4b	81	1	t	t	NNP
cord-048487-kamvao4b	81	2	j	j	NNP
cord-048487-kamvao4b	81	3	-1	-1	NNP
cord-048487-kamvao4b	81	4	is	be	VBZ
cord-048487-kamvao4b	81	5	used	use	VBN
cord-048487-kamvao4b	81	6	rather	rather	RB
cord-048487-kamvao4b	81	7	than	than	IN
cord-048487-kamvao4b	82	1	t	t	NNP
cord-048487-kamvao4b	82	2	i	i	NNP
cord-048487-kamvao4b	82	3	+	+	CC
cord-048487-kamvao4b	82	4	t	t	NNP
cord-048487-kamvao4b	82	5	j	j	NNP
cord-048487-kamvao4b	82	6	to	to	TO
cord-048487-kamvao4b	82	7	account	account	VB
cord-048487-kamvao4b	82	8	for	for	IN
cord-048487-kamvao4b	82	9	the	the	DT
cord-048487-kamvao4b	82	10	expected	expected	JJ
cord-048487-kamvao4b	82	11	error	error	NN
cord-048487-kamvao4b	82	12	coming	come	VBG
cord-048487-kamvao4b	82	13	from	from	IN
cord-048487-kamvao4b	82	14	the	the	DT
cord-048487-kamvao4b	82	15	uniformly	uniformly	RB
cord-048487-kamvao4b	82	16	The	the	DT
cord-048487-kamvao4b	82	17	phylogenetic	phylogenetic	JJ
cord-048487-kamvao4b	82	18	relationships	relationship	NNS
cord-048487-kamvao4b	82	19	between	between	IN
cord-048487-kamvao4b	82	20	three	three	CD
cord-048487-kamvao4b	82	21	sequences	sequence	NNS
cord-048487-kamvao4b	82	22	s	s	NNP
cord-048487-kamvao4b	82	23	i	i	NNP
cord-048487-kamvao4b	82	24	,	,	,
cord-048487-kamvao4b	82	25	s	s	NNP
cord-048487-kamvao4b	82	26	j	j	NNP
cord-048487-kamvao4b	82	27	and	and	CC
cord-048487-kamvao4b	82	28	s	s	NNP
cord-048487-kamvao4b	82	29	k	k	XX
cord-048487-kamvao4b	82	30	,	,	,
cord-048487-kamvao4b	82	31	sampled	sample	VBN
cord-048487-kamvao4b	82	32	on	on	IN
cord-048487-kamvao4b	82	33	dates	date	NNS
cord-048487-kamvao4b	82	34	t	t	NNP
cord-048487-kamvao4b	82	35	i	i	NNP
cord-048487-kamvao4b	82	36	,	,	,
cord-048487-kamvao4b	82	37	t	t	NNP
cord-048487-kamvao4b	82	38	j	j	NNP
cord-048487-kamvao4b	82	39	and	and	CC
cord-048487-kamvao4b	82	40	t	t	NNP
cord-048487-kamvao4b	82	41	k	k	NNP
cord-048487-kamvao4b	82	42	respectively	respectively	RB
cord-048487-kamvao4b	82	43	As	as	IN
cord-048487-kamvao4b	82	44	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	82	45	data	data	NN
cord-048487-kamvao4b	82	46	increases	increase	NNS
cord-048487-kamvao4b	82	47	without	without	IN
cord-048487-kamvao4b	82	48	bound	bind	VBN
cord-048487-kamvao4b	82	49	,	,	,
cord-048487-kamvao4b	82	50	K	K	NNP
cord-048487-kamvao4b	82	51	ij	ij	NN
cord-048487-kamvao4b	82	52	→	→	SYM
cord-048487-kamvao4b	82	53	D	d	NN
cord-048487-kamvao4b	82	54	ij	ij	NN
cord-048487-kamvao4b	82	55	and	and	CC
cord-048487-kamvao4b	82	56	→	→	SYM
cord-048487-kamvao4b	82	57	p	p	NN
cord-048487-kamvao4b	82	58	ij	ij	NN
cord-048487-kamvao4b	82	59	,	,	,
cord-048487-kamvao4b	82	60	ensuring	ensure	VBG
cord-048487-kamvao4b	82	61	that	that	IN
cord-048487-kamvao4b	82	62	→	→	SYM
cord-048487-kamvao4b	82	63	α	α	NN
cord-048487-kamvao4b	82	64	ij	ij	NN
cord-048487-kamvao4b	82	65	.	.	.
cord-048487-kamvao4b	83	1	For	for	IN
cord-048487-kamvao4b	83	2	finite	finite	JJ
cord-048487-kamvao4b	83	3	sequence	sequence	NN
cord-048487-kamvao4b	83	4	lengths	length	NNS
cord-048487-kamvao4b	83	5	,	,	,
cord-048487-kamvao4b	83	6	this	this	DT
cord-048487-kamvao4b	83	7	relation	relation	NN
cord-048487-kamvao4b	83	8	ensures	ensure	VBZ
cord-048487-kamvao4b	83	9	that	that	DT
cord-048487-kamvao4b	83	10	.	.	.
cord-048487-kamvao4b	84	1	To	to	TO
cord-048487-kamvao4b	84	2	gain	gain	VB
cord-048487-kamvao4b	84	3	an	an	DT
cord-048487-kamvao4b	84	4	understanding	understanding	NN
cord-048487-kamvao4b	84	5	of	of	IN
cord-048487-kamvao4b	84	6	this	this	DT
cord-048487-kamvao4b	84	7	estimator	estimator	NN
cord-048487-kamvao4b	84	8	,	,	,
cord-048487-kamvao4b	84	9	we	-PRON-	PRP
cord-048487-kamvao4b	84	10	note	note	VBP
cord-048487-kamvao4b	84	11	that	that	IN
cord-048487-kamvao4b	84	12	with	with	IN
cord-048487-kamvao4b	84	13	a	a	DT
cord-048487-kamvao4b	84	14	standard	standard	JJ
cord-048487-kamvao4b	84	15	model	model	NN
cord-048487-kamvao4b	84	16	of	of	IN
cord-048487-kamvao4b	84	17	substitution	substitution	NN
cord-048487-kamvao4b	84	18	(	(	-LRB-
cord-048487-kamvao4b	84	19	e.g.	e.g.	RB
cord-048487-kamvao4b	84	20	JC69	JC69	NNP
cord-048487-kamvao4b	84	21	,	,	,
cord-048487-kamvao4b	84	22	HKY85	HKY85	NNP
cord-048487-kamvao4b	84	23	)	)	-RRB-
cord-048487-kamvao4b	84	24	,	,	,
cord-048487-kamvao4b	84	25	a	a	DT
cord-048487-kamvao4b	84	26	rate	rate	NN
cord-048487-kamvao4b	84	27	of	of	IN
cord-048487-kamvao4b	84	28	substitution	substitution	NN
cord-048487-kamvao4b	84	29	of	of	IN
cord-048487-kamvao4b	84	30	10	10	CD
cord-048487-kamvao4b	84	31	-4	-4	NNS
cord-048487-kamvao4b	84	32	(	(	-LRB-
cord-048487-kamvao4b	84	33	s	s	NNP
cord-048487-kamvao4b	84	34	/	/	SYM
cord-048487-kamvao4b	84	35	s	s	NNP
cord-048487-kamvao4b	84	36	/	/	SYM
cord-048487-kamvao4b	84	37	yr	yr	NN
cord-048487-kamvao4b	84	38	)	)	-RRB-
cord-048487-kamvao4b	84	39	and	and	CC
cord-048487-kamvao4b	84	40	a	a	DT
cord-048487-kamvao4b	84	41	sequence	sequence	NN
cord-048487-kamvao4b	84	42	of	of	IN
cord-048487-kamvao4b	84	43	2000	2000	CD
cord-048487-kamvao4b	84	44	nucleotides	nucleotide	NNS
cord-048487-kamvao4b	84	45	,	,	,
cord-048487-kamvao4b	84	46	the	the	DT
cord-048487-kamvao4b	84	47	above	above	JJ
cord-048487-kamvao4b	84	48	estimator	estimator	NN
cord-048487-kamvao4b	84	49	yields	yield	VBZ
cord-048487-kamvao4b	84	50	a	a	DT
cord-048487-kamvao4b	84	51	standard	standard	JJ
cord-048487-kamvao4b	84	52	error	error	NN
cord-048487-kamvao4b	84	53	of	of	IN
cord-048487-kamvao4b	84	54	approximately	approximately	RB
cord-048487-kamvao4b	84	55	23	23	CD
cord-048487-kamvao4b	84	56	years	year	NNS
cord-048487-kamvao4b	84	57	[	[	-LRB-
cord-048487-kamvao4b	84	58	20	20	CD
cord-048487-kamvao4b	84	59	]	]	-RRB-
cord-048487-kamvao4b	84	60	.	.	.
cord-048487-kamvao4b	85	1	The	the	DT
cord-048487-kamvao4b	85	2	above	above	JJ
cord-048487-kamvao4b	85	3	derivations	derivation	NNS
cord-048487-kamvao4b	85	4	express	express	VBP
cord-048487-kamvao4b	85	5	our	-PRON-	PRP$
cord-048487-kamvao4b	85	6	rate	rate	NN
cord-048487-kamvao4b	85	7	and	and	CC
cord-048487-kamvao4b	85	8	time	time	NN
cord-048487-kamvao4b	85	9	estimates	estimate	NNS
cord-048487-kamvao4b	85	10	for	for	IN
cord-048487-kamvao4b	85	11	a	a	DT
cord-048487-kamvao4b	85	12	single	single	JJ
cord-048487-kamvao4b	85	13	triplet	triplet	NN
cord-048487-kamvao4b	85	14	of	of	IN
cord-048487-kamvao4b	85	15	sequences	sequence	NNS
cord-048487-kamvao4b	85	16	.	.	.
cord-048487-kamvao4b	86	1	We	-PRON-	PRP
cord-048487-kamvao4b	86	2	now	now	RB
cord-048487-kamvao4b	86	3	consider	consider	VBP
cord-048487-kamvao4b	86	4	estimates	estimate	NNS
cord-048487-kamvao4b	86	5	that	that	WDT
cord-048487-kamvao4b	86	6	combine	combine	VBP
cord-048487-kamvao4b	86	7	information	information	NN
cord-048487-kamvao4b	86	8	across	across	IN
cord-048487-kamvao4b	86	9	multiple	multiple	JJ
cord-048487-kamvao4b	86	10	representative	representative	JJ
cord-048487-kamvao4b	86	11	sequences	sequence	NNS
cord-048487-kamvao4b	86	12	from	from	IN
cord-048487-kamvao4b	86	13	each	each	DT
cord-048487-kamvao4b	86	14	subtype	subtype	NN
cord-048487-kamvao4b	86	15	.	.	.
cord-048487-kamvao4b	87	1	For	for	IN
cord-048487-kamvao4b	87	2	discussion	discussion	NN
cord-048487-kamvao4b	87	3	,	,	,
cord-048487-kamvao4b	87	4	we	-PRON-	PRP
cord-048487-kamvao4b	87	5	label	label	VBP
cord-048487-kamvao4b	87	6	subtypes	subtype	VBZ
cord-048487-kamvao4b	87	7	A	A	NNP
cord-048487-kamvao4b	87	8	,	,	,
cord-048487-kamvao4b	87	9	B	b	NN
cord-048487-kamvao4b	87	10	and	and	CC
cord-048487-kamvao4b	87	11	C	C	NNP
cord-048487-kamvao4b	87	12	(	(	-LRB-
cord-048487-kamvao4b	87	13	which	which	WDT
cord-048487-kamvao4b	87	14	are	be	VBP
cord-048487-kamvao4b	87	15	only	only	RB
cord-048487-kamvao4b	87	16	incidentally	incidentally	RB
cord-048487-kamvao4b	87	17	the	the	DT
cord-048487-kamvao4b	87	18	same	same	JJ
cord-048487-kamvao4b	87	19	as	as	IN
cord-048487-kamvao4b	87	20	the	the	DT
cord-048487-kamvao4b	87	21	labels	label	NNS
cord-048487-kamvao4b	87	22	for	for	IN
cord-048487-kamvao4b	87	23	influenza	influenza	NN
cord-048487-kamvao4b	87	24	)	)	-RRB-
cord-048487-kamvao4b	88	1	and	and	CC
cord-048487-kamvao4b	88	2	we	-PRON-	PRP
cord-048487-kamvao4b	88	3	assume	assume	VBP
cord-048487-kamvao4b	88	4	the	the	DT
cord-048487-kamvao4b	88	5	topology	topology	NN
cord-048487-kamvao4b	88	6	in	in	IN
cord-048487-kamvao4b	88	7	Figure	figure	NN
cord-048487-kamvao4b	88	8	1	1	CD
cord-048487-kamvao4b	88	9	for	for	IN
cord-048487-kamvao4b	88	10	these	these	DT
cord-048487-kamvao4b	88	11	groups	group	NNS
cord-048487-kamvao4b	88	12	.	.	.
cord-048487-kamvao4b	89	1	We	-PRON-	PRP
cord-048487-kamvao4b	89	2	let	let	VBP
cord-048487-kamvao4b	89	3	n	n	NN
cord-048487-kamvao4b	89	4	r	r	NN
cord-048487-kamvao4b	89	5	,	,	,
cord-048487-kamvao4b	89	6	where	where	WRB
cord-048487-kamvao4b	89	7	r	r	NN
cord-048487-kamvao4b	89	8	∈	∈	NN
cord-048487-kamvao4b	89	9	{	{	-LRB-
cord-048487-kamvao4b	89	10	A	a	NN
cord-048487-kamvao4b	89	11	,	,	,
cord-048487-kamvao4b	89	12	where	where	WRB
cord-048487-kamvao4b	89	13	P	p	NN
cord-048487-kamvao4b	89	14	α	α	NN
cord-048487-kamvao4b	89	15	is	be	VBZ
cord-048487-kamvao4b	89	16	the	the	DT
cord-048487-kamvao4b	89	17	sum	sum	NN
cord-048487-kamvao4b	89	18	of	of	IN
cord-048487-kamvao4b	89	19	the	the	DT
cord-048487-kamvao4b	89	20	inverse	inverse	JJ
cord-048487-kamvao4b	89	21	variance	variance	NN
cord-048487-kamvao4b	89	22	of	of	IN
cord-048487-kamvao4b	89	23	each	each	DT
cord-048487-kamvao4b	89	24	estimate	estimate	NN
cord-048487-kamvao4b	89	25	,	,	,
cord-048487-kamvao4b	89	26	.	.	.
cord-048487-kamvao4b	90	1	Having	have	VBG
cord-048487-kamvao4b	90	2	found	find	VBN
cord-048487-kamvao4b	90	3	,	,	,
cord-048487-kamvao4b	90	4	we	-PRON-	PRP
cord-048487-kamvao4b	90	5	estimate	estimate	VBP
cord-048487-kamvao4b	90	6	its	-PRON-	PRP$
cord-048487-kamvao4b	90	7	variance	variance	NN
cord-048487-kamvao4b	90	8	by	by	IN
cord-048487-kamvao4b	90	9	a	a	DT
cord-048487-kamvao4b	90	10	bootstrap	bootstrap	NN
cord-048487-kamvao4b	90	11	resampling	resampling	NN
cord-048487-kamvao4b	90	12	of	of	IN
cord-048487-kamvao4b	90	13	sequences	sequence	NNS
cord-048487-kamvao4b	90	14	from	from	IN
cord-048487-kamvao4b	90	15	each	each	DT
cord-048487-kamvao4b	90	16	subtype	subtype	NN
cord-048487-kamvao4b	90	17	[	[	-LRB-
cord-048487-kamvao4b	90	18	8	8	CD
cord-048487-kamvao4b	90	19	]	]	-RRB-
cord-048487-kamvao4b	90	20	.	.	.
cord-048487-kamvao4b	91	1	The	the	DT
cord-048487-kamvao4b	91	2	computational	computational	JJ
cord-048487-kamvao4b	91	3	efficiency	efficiency	NN
cord-048487-kamvao4b	91	4	of	of	IN
cord-048487-kamvao4b	91	5	this	this	DT
cord-048487-kamvao4b	91	6	estimator	estimator	NN
cord-048487-kamvao4b	91	7	is	be	VBZ
cord-048487-kamvao4b	91	8	on	on	IN
cord-048487-kamvao4b	91	9	the	the	DT
cord-048487-kamvao4b	91	10	order	order	NN
cord-048487-kamvao4b	91	11	O(n	o(n	NN
cord-048487-kamvao4b	91	12	3	3	CD
cord-048487-kamvao4b	91	13	)	)	-RRB-
cord-048487-kamvao4b	91	14	for	for	IN
cord-048487-kamvao4b	91	15	a	a	DT
cord-048487-kamvao4b	91	16	tree	tree	NN
cord-048487-kamvao4b	91	17	of	of	IN
cord-048487-kamvao4b	91	18	n	n	NN
cord-048487-kamvao4b	91	19	taxa	taxon	NNS
cord-048487-kamvao4b	91	20	.	.	.
cord-048487-kamvao4b	92	1	This	this	DT
cord-048487-kamvao4b	92	2	is	be	VBZ
cord-048487-kamvao4b	92	3	natural	natural	JJ
cord-048487-kamvao4b	92	4	as	as	IN
cord-048487-kamvao4b	92	5	each	each	DT
cord-048487-kamvao4b	92	6	of	of	IN
cord-048487-kamvao4b	92	7	the	the	DT
cord-048487-kamvao4b	92	8	initial	initial	JJ
cord-048487-kamvao4b	92	9	rate	rate	NN
cord-048487-kamvao4b	92	10	estimates	estimate	NNS
cord-048487-kamvao4b	92	11	is	be	VBZ
cord-048487-kamvao4b	92	12	composed	compose	VBN
cord-048487-kamvao4b	92	13	of	of	IN
cord-048487-kamvao4b	92	14	information	information	NN
cord-048487-kamvao4b	92	15	concerning	concern	VBG
cord-048487-kamvao4b	92	16	three	three	CD
cord-048487-kamvao4b	92	17	taxa	taxon	NNS
cord-048487-kamvao4b	92	18	.	.	.
cord-048487-kamvao4b	93	1	While	while	IN
cord-048487-kamvao4b	93	2	the	the	DT
cord-048487-kamvao4b	93	3	growth	growth	NN
cord-048487-kamvao4b	93	4	of	of	IN
cord-048487-kamvao4b	93	5	computational	computational	JJ
cord-048487-kamvao4b	93	6	expense	expense	NN
cord-048487-kamvao4b	93	7	in	in	IN
cord-048487-kamvao4b	93	8	the	the	DT
cord-048487-kamvao4b	93	9	number	number	NN
cord-048487-kamvao4b	93	10	of	of	IN
cord-048487-kamvao4b	93	11	taxa	taxon	NNS
cord-048487-kamvao4b	93	12	may	may	MD
cord-048487-kamvao4b	93	13	appear	appear	VB
cord-048487-kamvao4b	93	14	unpleasant	unpleasant	JJ
cord-048487-kamvao4b	93	15	,	,	,
cord-048487-kamvao4b	93	16	in	in	IN
cord-048487-kamvao4b	93	17	practice	practice	NN
cord-048487-kamvao4b	93	18	this	this	DT
cord-048487-kamvao4b	93	19	algorithm	algorithm	NN
cord-048487-kamvao4b	93	20	is	be	VBZ
cord-048487-kamvao4b	93	21	both	both	CC
cord-048487-kamvao4b	93	22	fast	fast	JJ
cord-048487-kamvao4b	93	23	and	and	CC
cord-048487-kamvao4b	93	24	stable	stable	JJ
cord-048487-kamvao4b	93	25	,	,	,
cord-048487-kamvao4b	93	26	owing	owe	VBG
cord-048487-kamvao4b	93	27	to	to	IN
cord-048487-kamvao4b	93	28	the	the	DT
cord-048487-kamvao4b	93	29	absence	absence	NN
cord-048487-kamvao4b	93	30	of	of	IN
cord-048487-kamvao4b	93	31	costly	costly	JJ
cord-048487-kamvao4b	93	32	optimization	optimization	NN
cord-048487-kamvao4b	93	33	procedures	procedure	NNS
cord-048487-kamvao4b	93	34	for	for	IN
cord-048487-kamvao4b	93	35	parameter	parameter	NN
cord-048487-kamvao4b	93	36	inference	inference	NN
cord-048487-kamvao4b	93	37	,	,	,
cord-048487-kamvao4b	93	38	and	and	CC
cord-048487-kamvao4b	93	39	is	be	VBZ
cord-048487-kamvao4b	93	40	able	able	JJ
cord-048487-kamvao4b	93	41	to	to	TO
cord-048487-kamvao4b	93	42	handle	handle	VB
cord-048487-kamvao4b	93	43	data	data	NN
cord-048487-kamvao4b	93	44	sets	set	NNS
cord-048487-kamvao4b	93	45	of	of	IN
cord-048487-kamvao4b	93	46	thousands	thousand	NNS
cord-048487-kamvao4b	93	47	of	of	IN
cord-048487-kamvao4b	93	48	taxa	taxon	NNS
cord-048487-kamvao4b	93	49	.	.	.
cord-048487-kamvao4b	94	1	The	the	DT
cord-048487-kamvao4b	94	2	authors	author	NNS
cord-048487-kamvao4b	94	3	detail	detail	VBP
cord-048487-kamvao4b	94	4	the	the	DT
cord-048487-kamvao4b	94	5	computational	computational	JJ
cord-048487-kamvao4b	94	6	efficiency	efficiency	NN
cord-048487-kamvao4b	94	7	of	of	IN
cord-048487-kamvao4b	94	8	a	a	DT
cord-048487-kamvao4b	94	9	similar	similar	JJ
cord-048487-kamvao4b	94	10	statistic	statistic	NN
cord-048487-kamvao4b	94	11	in	in	IN
cord-048487-kamvao4b	94	12	[	[	-LRB-
cord-048487-kamvao4b	94	13	26	26	CD
cord-048487-kamvao4b	94	14	]	]	-RRB-
cord-048487-kamvao4b	94	15	.	.	.
cord-048487-kamvao4b	95	1	As	as	IN
cord-048487-kamvao4b	95	2	an	an	DT
cord-048487-kamvao4b	95	3	example	example	NN
cord-048487-kamvao4b	95	4	,	,	,
cord-048487-kamvao4b	95	5	for	for	IN
cord-048487-kamvao4b	95	6	the	the	DT
cord-048487-kamvao4b	95	7	data	datum	NNS
cord-048487-kamvao4b	95	8	presented	present	VBN
cord-048487-kamvao4b	95	9	below	below	IN
cord-048487-kamvao4b	95	10	all	all	DT
cord-048487-kamvao4b	95	11	computations	computation	NNS
cord-048487-kamvao4b	95	12	required	require	VBN
cord-048487-kamvao4b	95	13	only	only	RB
cord-048487-kamvao4b	95	14	a	a	DT
cord-048487-kamvao4b	95	15	few	few	JJ
cord-048487-kamvao4b	95	16	seconds	second	NNS
cord-048487-kamvao4b	95	17	on	on	IN
cord-048487-kamvao4b	95	18	a	a	DT
cord-048487-kamvao4b	95	19	desktop	desktop	NN
cord-048487-kamvao4b	95	20	computer	computer	NN
cord-048487-kamvao4b	95	21	.	.	.
cord-048487-kamvao4b	96	1	We	-PRON-	PRP
cord-048487-kamvao4b	96	2	demonstrate	demonstrate	VBP
cord-048487-kamvao4b	96	3	the	the	DT
cord-048487-kamvao4b	96	4	advantage	advantage	NN
cord-048487-kamvao4b	96	5	of	of	IN
cord-048487-kamvao4b	96	6	our	-PRON-	PRP$
cord-048487-kamvao4b	96	7	triplet	triplet	NN
cord-048487-kamvao4b	96	8	estimator	estimator	NN
cord-048487-kamvao4b	96	9	through	through	IN
cord-048487-kamvao4b	96	10	analysis	analysis	NN
cord-048487-kamvao4b	96	11	of	of	IN
cord-048487-kamvao4b	96	12	influenza	influenza	NN
cord-048487-kamvao4b	96	13	A	A	NNP
cord-048487-kamvao4b	96	14	-	-	:
cord-048487-kamvao4b	96	15	H3N2	H3N2	NNP
cord-048487-kamvao4b	96	16	/	/	SYM
cord-048487-kamvao4b	96	17	B	b	NN
cord-048487-kamvao4b	96	18	subtype	subtype	NN
cord-048487-kamvao4b	96	19	divergence	divergence	NN
cord-048487-kamvao4b	96	20	using	use	VBG
cord-048487-kamvao4b	96	21	the	the	DT
cord-048487-kamvao4b	96	22	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	96	23	(	(	-LRB-
cord-048487-kamvao4b	96	24	HA	HA	NNP
cord-048487-kamvao4b	96	25	)	)	-RRB-
cord-048487-kamvao4b	96	26	,	,	,
cord-048487-kamvao4b	96	27	matrix	matrix	NN
cord-048487-kamvao4b	96	28	protein	protein	NN
cord-048487-kamvao4b	96	29	(	(	-LRB-
cord-048487-kamvao4b	96	30	MP	MP	NNP
cord-048487-kamvao4b	96	31	)	)	-RRB-
cord-048487-kamvao4b	96	32	and	and	CC
cord-048487-kamvao4b	96	33	non	non	JJ
cord-048487-kamvao4b	96	34	-	-	JJ
cord-048487-kamvao4b	96	35	structural	structural	JJ
cord-048487-kamvao4b	96	36	(	(	-LRB-
cord-048487-kamvao4b	96	37	NS	NS	NNP
cord-048487-kamvao4b	96	38	)	)	-RRB-
cord-048487-kamvao4b	96	39	genes	gene	NNS
cord-048487-kamvao4b	96	40	.	.	.
cord-048487-kamvao4b	97	1	Each	each	DT
cord-048487-kamvao4b	97	2	analysis	analysis	NN
cord-048487-kamvao4b	97	3	is	be	VBZ
cord-048487-kamvao4b	97	4	performed	perform	VBN
cord-048487-kamvao4b	97	5	on	on	IN
cord-048487-kamvao4b	97	6	60	60	CD
cord-048487-kamvao4b	97	7	gene	gene	NN
cord-048487-kamvao4b	97	8	sequences	sequence	NNS
cord-048487-kamvao4b	97	9	constructed	construct	VBN
cord-048487-kamvao4b	97	10	from	from	IN
cord-048487-kamvao4b	97	11	20	20	CD
cord-048487-kamvao4b	97	12	genomes	genome	NNS
cord-048487-kamvao4b	97	13	each	each	DT
cord-048487-kamvao4b	97	14	drawn	draw	VBN
cord-048487-kamvao4b	97	15	from	from	IN
cord-048487-kamvao4b	97	16	influenza	influenza	NN
cord-048487-kamvao4b	97	17	subtypes	subtype	NNS
cord-048487-kamvao4b	98	1	A	a	LS
cord-048487-kamvao4b	98	2	-	-	:
cord-048487-kamvao4b	98	3	H3N2	H3N2	NNP
cord-048487-kamvao4b	98	4	,	,	,
cord-048487-kamvao4b	98	5	B	B	NNP
cord-048487-kamvao4b	98	6	and	and	CC
cord-048487-kamvao4b	98	7	C.	C.	NNP
cord-048487-kamvao4b	99	1	We	-PRON-	PRP
cord-048487-kamvao4b	99	2	download	download	VBP
cord-048487-kamvao4b	99	3	these	these	DT
cord-048487-kamvao4b	99	4	data	datum	NNS
cord-048487-kamvao4b	99	5	along	along	IN
cord-048487-kamvao4b	99	6	with	with	IN
cord-048487-kamvao4b	99	7	their	-PRON-	PRP$
cord-048487-kamvao4b	99	8	dates	date	NNS
cord-048487-kamvao4b	99	9	of	of	IN
cord-048487-kamvao4b	99	10	sampling	sampling	NN
cord-048487-kamvao4b	99	11	from	from	IN
cord-048487-kamvao4b	99	12	the	the	DT
cord-048487-kamvao4b	99	13	Los	Los	NNP
cord-048487-kamvao4b	99	14	Alamos	Alamos	NNP
cord-048487-kamvao4b	99	15	Influenza	Influenza	NNP
cord-048487-kamvao4b	99	16	Database	Database	NNP
cord-048487-kamvao4b	99	17	[	[	-LRB-
cord-048487-kamvao4b	99	18	16	16	CD
cord-048487-kamvao4b	99	19	]	]	-RRB-
cord-048487-kamvao4b	99	20	.	.	.
cord-048487-kamvao4b	100	1	We	-PRON-	PRP
cord-048487-kamvao4b	100	2	perform	perform	VBP
cord-048487-kamvao4b	100	3	sequence	sequence	NN
cord-048487-kamvao4b	100	4	alignment	alignment	NN
cord-048487-kamvao4b	100	5	using	use	VBG
cord-048487-kamvao4b	100	6	ClustalX	clustalx	PRP
cord-048487-kamvao4b	100	7	[	[	-LRB-
cord-048487-kamvao4b	100	8	24	24	CD
cord-048487-kamvao4b	100	9	,	,	,
cord-048487-kamvao4b	100	10	version	version	NN
cord-048487-kamvao4b	100	11	1.8	1.8	CD
cord-048487-kamvao4b	100	12	]	]	-RRB-
cord-048487-kamvao4b	100	13	.	.	.
cord-048487-kamvao4b	101	1	For	for	IN
cord-048487-kamvao4b	101	2	consistency	consistency	NN
cord-048487-kamvao4b	101	3	with	with	IN
cord-048487-kamvao4b	101	4	previous	previous	JJ
cord-048487-kamvao4b	101	5	studies	study	NNS
cord-048487-kamvao4b	101	6	of	of	IN
cord-048487-kamvao4b	101	7	A	A	NNP
cord-048487-kamvao4b	101	8	-	-	:
cord-048487-kamvao4b	101	9	H3N2	H3N2	NNP
cord-048487-kamvao4b	101	10	HA	HA	NNP
cord-048487-kamvao4b	101	11	evolution	evolution	NN
cord-048487-kamvao4b	101	12	,	,	,
cord-048487-kamvao4b	101	13	we	-PRON-	PRP
cord-048487-kamvao4b	101	14	use	use	VBP
cord-048487-kamvao4b	101	15	the	the	DT
cord-048487-kamvao4b	101	16	HKY	HKY	NNP
cord-048487-kamvao4b	101	17	model	model	NN
cord-048487-kamvao4b	101	18	of	of	IN
cord-048487-kamvao4b	101	19	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	101	20	substitution	substitution	NN
cord-048487-kamvao4b	101	21	[	[	-LRB-
cord-048487-kamvao4b	101	22	10	10	CD
cord-048487-kamvao4b	101	23	]	]	-RRB-
cord-048487-kamvao4b	101	24	.	.	.
cord-048487-kamvao4b	102	1	We	-PRON-	PRP
cord-048487-kamvao4b	102	2	use	use	VBP
cord-048487-kamvao4b	102	3	the	the	DT
cord-048487-kamvao4b	102	4	TREBLE	treble	NN
cord-048487-kamvao4b	102	5	algorithm	algorithm	NN
cord-048487-kamvao4b	102	6	,	,	,
cord-048487-kamvao4b	102	7	which	which	WDT
cord-048487-kamvao4b	102	8	implements	implement	VBZ
cord-048487-kamvao4b	102	9	a	a	DT
cord-048487-kamvao4b	102	10	MCA	MCA	NNP
cord-048487-kamvao4b	102	11	,	,	,
cord-048487-kamvao4b	102	12	on	on	IN
cord-048487-kamvao4b	102	13	sets	set	NNS
cord-048487-kamvao4b	102	14	of	of	IN
cord-048487-kamvao4b	102	15	sequences	sequence	NNS
cord-048487-kamvao4b	102	16	solely	solely	RB
cord-048487-kamvao4b	102	17	drawn	draw	VBN
cord-048487-kamvao4b	102	18	from	from	IN
cord-048487-kamvao4b	102	19	a	a	DT
cord-048487-kamvao4b	102	20	single	single	JJ
cord-048487-kamvao4b	102	21	subtype	subtype	NN
cord-048487-kamvao4b	102	22	to	to	TO
cord-048487-kamvao4b	102	23	derive	derive	VB
cord-048487-kamvao4b	102	24	within	within	IN
cord-048487-kamvao4b	102	25	-	-	HYPH
cord-048487-kamvao4b	102	26	subtype	subtype	NN
cord-048487-kamvao4b	102	27	rates	rate	NNS
cord-048487-kamvao4b	102	28	.	.	.
cord-048487-kamvao4b	103	1	The	the	DT
cord-048487-kamvao4b	103	2	phylogenetic	phylogenetic	JJ
cord-048487-kamvao4b	103	3	tree	tree	NN
cord-048487-kamvao4b	103	4	,	,	,
cord-048487-kamvao4b	103	5	generated	generate	VBN
cord-048487-kamvao4b	103	6	by	by	IN
cord-048487-kamvao4b	103	7	TREBLE	TREBLE	NNP
cord-048487-kamvao4b	103	8	,	,	,
cord-048487-kamvao4b	103	9	for	for	IN
cord-048487-kamvao4b	103	10	the	the	DT
cord-048487-kamvao4b	103	11	HA	HA	NNP
cord-048487-kamvao4b	103	12	gene	gene	NN
cord-048487-kamvao4b	103	13	is	be	VBZ
cord-048487-kamvao4b	103	14	depicted	depict	VBN
cord-048487-kamvao4b	103	15	in	in	IN
cord-048487-kamvao4b	103	16	Figure	figure	NN
cord-048487-kamvao4b	103	17	2	2	CD
cord-048487-kamvao4b	103	18	(	(	-LRB-
cord-048487-kamvao4b	103	19	±	±	CD
cord-048487-kamvao4b	103	20	0.48	0.48	CD
cord-048487-kamvao4b	103	21	)	)	-RRB-
cord-048487-kamvao4b	103	22	×	×	NN
cord-048487-kamvao4b	103	23	10	10	CD
cord-048487-kamvao4b	104	1	-3	-3	NNP
cord-048487-kamvao4b	105	1	s	s	NNP
cord-048487-kamvao4b	105	2	/	/	SYM
cord-048487-kamvao4b	105	3	s	s	NNP
cord-048487-kamvao4b	105	4	/	/	SYM
cord-048487-kamvao4b	105	5	yr	yr	NN
cord-048487-kamvao4b	105	6	and	and	CC
cord-048487-kamvao4b	105	7	the	the	DT
cord-048487-kamvao4b	105	8	subtype	subtype	NN
cord-048487-kamvao4b	105	9	C	c	NN
cord-048487-kamvao4b	105	10	rate	rate	NN
cord-048487-kamvao4b	105	11	is	be	VBZ
cord-048487-kamvao4b	105	12	1.31	1.31	CD
cord-048487-kamvao4b	105	13	(	(	-LRB-
cord-048487-kamvao4b	105	14	±	±	CD
cord-048487-kamvao4b	105	15	0.33	0.33	CD
cord-048487-kamvao4b	105	16	)	)	-RRB-
cord-048487-kamvao4b	105	17	×	×	NN
cord-048487-kamvao4b	105	18	10	10	CD
cord-048487-kamvao4b	106	1	-3	-3	NNP
cord-048487-kamvao4b	107	1	s	s	NNP
cord-048487-kamvao4b	107	2	/	/	SYM
cord-048487-kamvao4b	107	3	s	s	NNP
cord-048487-kamvao4b	107	4	/	/	SYM
cord-048487-kamvao4b	107	5	yr	yr	NN
cord-048487-kamvao4b	107	6	.	.	.
cord-048487-kamvao4b	108	1	Lastly	lastly	RB
cord-048487-kamvao4b	108	2	,	,	,
cord-048487-kamvao4b	108	3	for	for	IN
cord-048487-kamvao4b	108	4	the	the	DT
cord-048487-kamvao4b	108	5	NS	NS	NNP
cord-048487-kamvao4b	108	6	gene	gene	NN
cord-048487-kamvao4b	108	7	,	,	,
cord-048487-kamvao4b	108	8	the	the	DT
cord-048487-kamvao4b	108	9	rates	rate	NNS
cord-048487-kamvao4b	108	10	are	be	VBP
cord-048487-kamvao4b	108	11	similar	similar	JJ
cord-048487-kamvao4b	108	12	to	to	IN
cord-048487-kamvao4b	108	13	those	those	DT
cord-048487-kamvao4b	108	14	of	of	IN
cord-048487-kamvao4b	108	15	the	the	DT
cord-048487-kamvao4b	108	16	MP	MP	NNP
cord-048487-kamvao4b	108	17	gene	gene	NN
cord-048487-kamvao4b	108	18	.	.	.
cord-048487-kamvao4b	109	1	The	the	DT
cord-048487-kamvao4b	109	2	subtype	subtype	NN
cord-048487-kamvao4b	109	3	A	a	NN
cord-048487-kamvao4b	109	4	-	-	:
cord-048487-kamvao4b	109	5	H3N2	H3N2	NNP
cord-048487-kamvao4b	109	6	rate	rate	NN
cord-048487-kamvao4b	109	7	is	be	VBZ
cord-048487-kamvao4b	109	8	2.14	2.14	CD
cord-048487-kamvao4b	109	9	(	(	-LRB-
cord-048487-kamvao4b	109	10	±	±	CD
cord-048487-kamvao4b	109	11	0.25	0.25	CD
cord-048487-kamvao4b	109	12	)	)	-RRB-
cord-048487-kamvao4b	109	13	×	×	NN
cord-048487-kamvao4b	109	14	10	10	CD
cord-048487-kamvao4b	110	1	-3	-3	NNP
cord-048487-kamvao4b	111	1	s	s	NNP
cord-048487-kamvao4b	111	2	/	/	SYM
cord-048487-kamvao4b	111	3	s	s	NNP
cord-048487-kamvao4b	111	4	/	/	SYM
cord-048487-kamvao4b	111	5	yr	yr	NN
cord-048487-kamvao4b	111	6	,	,	,
cord-048487-kamvao4b	111	7	the	the	DT
cord-048487-kamvao4b	111	8	subtype	subtype	NN
cord-048487-kamvao4b	111	9	B	b	NN
cord-048487-kamvao4b	111	10	rate	rate	NN
cord-048487-kamvao4b	111	11	is	be	VBZ
cord-048487-kamvao4b	111	12	1.92	1.92	CD
cord-048487-kamvao4b	111	13	(	(	-LRB-
cord-048487-kamvao4b	111	14	±	±	CD
cord-048487-kamvao4b	111	15	0.20	0.20	CD
cord-048487-kamvao4b	111	16	)	)	-RRB-
cord-048487-kamvao4b	111	17	×	×	NN
cord-048487-kamvao4b	111	18	10	10	CD
cord-048487-kamvao4b	112	1	-3	-3	NNP
cord-048487-kamvao4b	112	2	s	s	NNP
cord-048487-kamvao4b	112	3	/	/	SYM
cord-048487-kamvao4b	112	4	s	s	NNP
cord-048487-kamvao4b	112	5	/	/	SYM
cord-048487-kamvao4b	112	6	yr	yr	NN
cord-048487-kamvao4b	112	7	,	,	,
cord-048487-kamvao4b	112	8	and	and	CC
cord-048487-kamvao4b	112	9	the	the	DT
cord-048487-kamvao4b	112	10	subtype	subtype	NN
cord-048487-kamvao4b	112	11	C	c	NN
cord-048487-kamvao4b	112	12	rate	rate	NN
cord-048487-kamvao4b	112	13	is	be	VBZ
cord-048487-kamvao4b	112	14	1.68	1.68	CD
cord-048487-kamvao4b	112	15	(	(	-LRB-
cord-048487-kamvao4b	112	16	±	±	CD
cord-048487-kamvao4b	112	17	0.51	0.51	CD
cord-048487-kamvao4b	112	18	)	)	-RRB-
cord-048487-kamvao4b	113	1	×	×	NN
cord-048487-kamvao4b	113	2	10	10	CD
cord-048487-kamvao4b	114	1	-3	-3	NNP
cord-048487-kamvao4b	114	2	s	s	NNP
cord-048487-kamvao4b	114	3	/	/	SYM
cord-048487-kamvao4b	114	4	s	s	NNP
cord-048487-kamvao4b	114	5	/	/	SYM
cord-048487-kamvao4b	114	6	yr	yr	NN
cord-048487-kamvao4b	114	7	.	.	.
cord-048487-kamvao4b	115	1	Table	table	NN
cord-048487-kamvao4b	115	2	1	1	CD
cord-048487-kamvao4b	115	3	presents	present	VBZ
cord-048487-kamvao4b	115	4	these	these	DT
cord-048487-kamvao4b	115	5	results	result	NNS
cord-048487-kamvao4b	115	6	.	.	.
cord-048487-kamvao4b	116	1	Figure	figure	NN
cord-048487-kamvao4b	116	2	3	3	CD
cord-048487-kamvao4b	116	3	provides	provide	VBZ
cord-048487-kamvao4b	116	4	histograms	histogram	NNS
cord-048487-kamvao4b	116	5	of	of	IN
cord-048487-kamvao4b	116	6	the	the	DT
cord-048487-kamvao4b	116	7	bootstrap	bootstrap	NN
cord-048487-kamvao4b	116	8	distributions	distribution	NNS
cord-048487-kamvao4b	116	9	for	for	IN
cord-048487-kamvao4b	116	10	all	all	DT
cord-048487-kamvao4b	116	11	three	three	CD
cord-048487-kamvao4b	116	12	genes	gene	NNS
cord-048487-kamvao4b	116	13	and	and	CC
cord-048487-kamvao4b	116	14	subtypes	subtype	NNS
cord-048487-kamvao4b	116	15	.	.	.
cord-048487-kamvao4b	117	1	Assuming	assume	VBG
cord-048487-kamvao4b	117	2	a	a	DT
cord-048487-kamvao4b	117	3	molecular	molecular	JJ
cord-048487-kamvao4b	117	4	clock	clock	NN
cord-048487-kamvao4b	117	5	within	within	IN
cord-048487-kamvao4b	117	6	a	a	DT
cord-048487-kamvao4b	117	7	subtype	subtype	NN
cord-048487-kamvao4b	117	8	and	and	CC
cord-048487-kamvao4b	117	9	with	with	IN
cord-048487-kamvao4b	117	10	the	the	DT
cord-048487-kamvao4b	117	11	rates	rate	NNS
cord-048487-kamvao4b	117	12	above	above	RB
cord-048487-kamvao4b	117	13	,	,	,
cord-048487-kamvao4b	117	14	we	-PRON-	PRP
cord-048487-kamvao4b	117	15	generated	generate	VBD
cord-048487-kamvao4b	117	16	the	the	DT
cord-048487-kamvao4b	117	17	corresponding	corresponding	JJ
cord-048487-kamvao4b	117	18	dates	date	NNS
cord-048487-kamvao4b	117	19	of	of	IN
cord-048487-kamvao4b	117	20	the	the	DT
cord-048487-kamvao4b	117	21	TMCRA	TMCRA	NNS
cord-048487-kamvao4b	117	22	.	.	.
cord-048487-kamvao4b	118	1	Figure	figure	NN
cord-048487-kamvao4b	118	2	3	3	CD
cord-048487-kamvao4b	118	3	shows	show	VBZ
cord-048487-kamvao4b	118	4	histograms	histogram	NNS
cord-048487-kamvao4b	118	5	of	of	IN
cord-048487-kamvao4b	118	6	the	the	DT
cord-048487-kamvao4b	118	7	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	118	8	estimates	estimate	NNS
cord-048487-kamvao4b	118	9	for	for	IN
cord-048487-kamvao4b	118	10	different	different	JJ
cord-048487-kamvao4b	118	11	genes	gene	NNS
cord-048487-kamvao4b	118	12	and	and	CC
cord-048487-kamvao4b	118	13	subtypes	subtype	NNS
cord-048487-kamvao4b	118	14	.	.	.
cord-048487-kamvao4b	119	1	All	all	DT
cord-048487-kamvao4b	119	2	genes	gene	NNS
cord-048487-kamvao4b	119	3	are	be	VBP
cord-048487-kamvao4b	119	4	similar	similar	JJ
cord-048487-kamvao4b	119	5	in	in	IN
cord-048487-kamvao4b	119	6	dating	date	VBG
cord-048487-kamvao4b	119	7	the	the	DT
cord-048487-kamvao4b	119	8	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	119	9	for	for	IN
cord-048487-kamvao4b	119	10	A	A	NNP
cord-048487-kamvao4b	119	11	-	-	:
cord-048487-kamvao4b	119	12	H3N2	H3N2	NNP
cord-048487-kamvao4b	119	13	to	to	IN
cord-048487-kamvao4b	119	14	approximately	approximately	RB
cord-048487-kamvao4b	119	15	1965	1965	CD
cord-048487-kamvao4b	119	16	(	(	-LRB-
cord-048487-kamvao4b	119	17	1964	1964	CD
cord-048487-kamvao4b	119	18	,	,	,
cord-048487-kamvao4b	119	19	1965	1965	CD
cord-048487-kamvao4b	119	20	,	,	,
cord-048487-kamvao4b	119	21	and	and	CC
cord-048487-kamvao4b	119	22	1962	1962	CD
cord-048487-kamvao4b	119	23	for	for	IN
cord-048487-kamvao4b	119	24	HA	HA	NNP
cord-048487-kamvao4b	119	25	,	,	,
cord-048487-kamvao4b	119	26	MP	MP	NNP
cord-048487-kamvao4b	119	27	and	and	CC
cord-048487-kamvao4b	119	28	NS	NS	NNP
cord-048487-kamvao4b	119	29	genes	gene	NNS
cord-048487-kamvao4b	119	30	,	,	,
cord-048487-kamvao4b	119	31	respectively	respectively	RB
cord-048487-kamvao4b	119	32	)	)	-RRB-
cord-048487-kamvao4b	119	33	.	.	.
cord-048487-kamvao4b	120	1	These	these	DT
cord-048487-kamvao4b	120	2	dates	date	NNS
cord-048487-kamvao4b	120	3	are	be	VBP
cord-048487-kamvao4b	120	4	consistent	consistent	JJ
cord-048487-kamvao4b	120	5	with	with	IN
cord-048487-kamvao4b	120	6	the	the	DT
cord-048487-kamvao4b	120	7	emergence	emergence	NN
cord-048487-kamvao4b	120	8	of	of	IN
cord-048487-kamvao4b	120	9	the	the	DT
cord-048487-kamvao4b	120	10	A	A	NNP
cord-048487-kamvao4b	120	11	-	-	HYPH
cord-048487-kamvao4b	120	12	H3N2	H3N2	NNP
cord-048487-kamvao4b	120	13	subtype	subtype	NN
cord-048487-kamvao4b	120	14	into	into	IN
cord-048487-kamvao4b	120	15	global	global	JJ
cord-048487-kamvao4b	120	16	circulation	circulation	NN
cord-048487-kamvao4b	120	17	dur	dur	NN
cord-048487-kamvao4b	120	18	-	-	:
cord-048487-kamvao4b	120	19	ing	e	VBG
cord-048487-kamvao4b	120	20	the	the	DT
cord-048487-kamvao4b	120	21	1968	1968	CD
cord-048487-kamvao4b	120	22	pandemic	pandemic	NN
cord-048487-kamvao4b	120	23	[	[	-LRB-
cord-048487-kamvao4b	120	24	1	1	CD
cord-048487-kamvao4b	120	25	]	]	-RRB-
cord-048487-kamvao4b	120	26	.	.	.
cord-048487-kamvao4b	121	1	Both	both	DT
cord-048487-kamvao4b	121	2	the	the	DT
cord-048487-kamvao4b	121	3	MP	MP	NNP
cord-048487-kamvao4b	121	4	and	and	CC
cord-048487-kamvao4b	121	5	NS	NS	NNP
cord-048487-kamvao4b	121	6	genes	gene	NNS
cord-048487-kamvao4b	121	7	date	date	VBP
cord-048487-kamvao4b	121	8	the	the	DT
cord-048487-kamvao4b	121	9	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	121	10	of	of	IN
cord-048487-kamvao4b	121	11	subtype	subtype	NN
cord-048487-kamvao4b	121	12	B	b	NN
cord-048487-kamvao4b	121	13	to	to	IN
cord-048487-kamvao4b	121	14	1943	1943	CD
cord-048487-kamvao4b	121	15	,	,	,
cord-048487-kamvao4b	121	16	while	while	IN
cord-048487-kamvao4b	121	17	the	the	DT
cord-048487-kamvao4b	121	18	HA	HA	NNP
cord-048487-kamvao4b	121	19	rate	rate	NN
cord-048487-kamvao4b	121	20	places	place	NNS
cord-048487-kamvao4b	121	21	the	the	DT
cord-048487-kamvao4b	121	22	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	121	23	at	at	IN
cord-048487-kamvao4b	121	24	1953	1953	CD
cord-048487-kamvao4b	121	25	.	.	.
cord-048487-kamvao4b	122	1	This	this	DT
cord-048487-kamvao4b	122	2	latter	latter	JJ
cord-048487-kamvao4b	122	3	value	value	NN
cord-048487-kamvao4b	122	4	is	be	VBZ
cord-048487-kamvao4b	122	5	inconsistent	inconsistent	JJ
cord-048487-kamvao4b	122	6	with	with	IN
cord-048487-kamvao4b	122	7	the	the	DT
cord-048487-kamvao4b	122	8	influenza	influenza	NN
cord-048487-kamvao4b	122	9	B	b	IN
cord-048487-kamvao4b	122	10	sub	sub	NN
cord-048487-kamvao4b	122	11	-	-	NNS
cord-048487-kamvao4b	122	12	epidemics	epidemic	NNS
cord-048487-kamvao4b	122	13	of	of	IN
cord-048487-kamvao4b	122	14	1950	1950	CD
cord-048487-kamvao4b	122	15	-	-	SYM
cord-048487-kamvao4b	122	16	51	51	CD
cord-048487-kamvao4b	122	17	but	but	CC
cord-048487-kamvao4b	122	18	is	be	VBZ
cord-048487-kamvao4b	122	19	consistent	consistent	JJ
cord-048487-kamvao4b	122	20	with	with	IN
cord-048487-kamvao4b	122	21	the	the	DT
cord-048487-kamvao4b	122	22	emergence	emergence	NN
cord-048487-kamvao4b	122	23	of	of	IN
cord-048487-kamvao4b	122	24	the	the	DT
cord-048487-kamvao4b	122	25	more	more	RBR
cord-048487-kamvao4b	122	26	lethal	lethal	JJ
cord-048487-kamvao4b	122	27	Victoria	Victoria	NNP
cord-048487-kamvao4b	122	28	strain	strain	NN
cord-048487-kamvao4b	122	29	of	of	IN
cord-048487-kamvao4b	122	30	influenza	influenza	NN
cord-048487-kamvao4b	122	31	B	b	NN
cord-048487-kamvao4b	122	32	in	in	IN
cord-048487-kamvao4b	122	33	1953	1953	CD
cord-048487-kamvao4b	122	34	[	[	-LRB-
cord-048487-kamvao4b	122	35	11	11	CD
cord-048487-kamvao4b	122	36	]	]	-RRB-
cord-048487-kamvao4b	122	37	.	.	.
cord-048487-kamvao4b	123	1	Each	each	DT
cord-048487-kamvao4b	123	2	of	of	IN
cord-048487-kamvao4b	123	3	these	these	DT
cord-048487-kamvao4b	123	4	estimates	estimate	NNS
cord-048487-kamvao4b	123	5	has	have	VBZ
cord-048487-kamvao4b	123	6	a	a	DT
cord-048487-kamvao4b	123	7	standard	standard	JJ
cord-048487-kamvao4b	123	8	error	error	NN
cord-048487-kamvao4b	123	9	of	of	IN
cord-048487-kamvao4b	123	10	approximately	approximately	RB
cord-048487-kamvao4b	123	11	2	2	CD
cord-048487-kamvao4b	123	12	years	year	NNS
cord-048487-kamvao4b	123	13	and	and	CC
cord-048487-kamvao4b	123	14	so	so	RB
cord-048487-kamvao4b	123	15	these	these	DT
cord-048487-kamvao4b	123	16	discrepancies	discrepancy	NNS
cord-048487-kamvao4b	123	17	may	may	MD
cord-048487-kamvao4b	123	18	be	be	VB
cord-048487-kamvao4b	123	19	accounted	account	VBN
cord-048487-kamvao4b	123	20	by	by	IN
cord-048487-kamvao4b	123	21	measurement	measurement	NN
cord-048487-kamvao4b	123	22	uncertainty	uncertainty	NN
cord-048487-kamvao4b	123	23	.	.	.
cord-048487-kamvao4b	124	1	The	the	DT
cord-048487-kamvao4b	124	2	10	10	CD
cord-048487-kamvao4b	124	3	year	year	NN
cord-048487-kamvao4b	124	4	gap	gap	NN
cord-048487-kamvao4b	124	5	between	between	IN
cord-048487-kamvao4b	124	6	the	the	DT
cord-048487-kamvao4b	124	7	TMCRA	TMCRA	NNP
cord-048487-kamvao4b	124	8	suggested	suggest	VBN
cord-048487-kamvao4b	124	9	by	by	IN
cord-048487-kamvao4b	124	10	the	the	DT
cord-048487-kamvao4b	124	11	different	different	JJ
cord-048487-kamvao4b	124	12	genes	gene	NNS
cord-048487-kamvao4b	124	13	can	can	MD
cord-048487-kamvao4b	124	14	be	be	VB
cord-048487-kamvao4b	124	15	explained	explain	VBN
cord-048487-kamvao4b	124	16	by	by	IN
cord-048487-kamvao4b	124	17	a	a	DT
cord-048487-kamvao4b	124	18	reassortment	reassortment	JJ
cord-048487-kamvao4b	124	19	event	event	NN
cord-048487-kamvao4b	124	20	.	.	.
cord-048487-kamvao4b	125	1	Finally	finally	RB
cord-048487-kamvao4b	125	2	,	,	,
cord-048487-kamvao4b	125	3	the	the	DT
cord-048487-kamvao4b	125	4	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	125	5	of	of	IN
cord-048487-kamvao4b	125	6	subtype	subtype	NN
cord-048487-kamvao4b	125	7	C	C	NNP
cord-048487-kamvao4b	125	8	is	be	VBZ
cord-048487-kamvao4b	125	9	calculated	calculate	VBN
cord-048487-kamvao4b	125	10	as	as	IN
cord-048487-kamvao4b	125	11	1952	1952	CD
cord-048487-kamvao4b	125	12	and	and	CC
cord-048487-kamvao4b	125	13	1953	1953	CD
cord-048487-kamvao4b	125	14	by	by	IN
cord-048487-kamvao4b	125	15	the	the	DT
cord-048487-kamvao4b	125	16	MP	MP	NNP
cord-048487-kamvao4b	125	17	and	and	CC
cord-048487-kamvao4b	125	18	NS	NS	NNP
cord-048487-kamvao4b	125	19	genes	gene	NNS
cord-048487-kamvao4b	125	20	,	,	,
cord-048487-kamvao4b	125	21	respectively	respectively	RB
cord-048487-kamvao4b	125	22	,	,	,
cord-048487-kamvao4b	125	23	while	while	IN
cord-048487-kamvao4b	125	24	the	the	DT
cord-048487-kamvao4b	125	25	HA	HA	NNP
cord-048487-kamvao4b	125	26	gene	gene	NN
cord-048487-kamvao4b	125	27	places	place	VBZ
cord-048487-kamvao4b	125	28	the	the	DT
cord-048487-kamvao4b	125	29	TMCRA	TMCRA	NNP
cord-048487-kamvao4b	125	30	at	at	IN
cord-048487-kamvao4b	125	31	1906	1906	CD
cord-048487-kamvao4b	125	32	.	.	.
cord-048487-kamvao4b	126	1	This	this	DT
cord-048487-kamvao4b	126	2	nearly	nearly	RB
cord-048487-kamvao4b	126	3	half	half	JJ
cord-048487-kamvao4b	126	4	century	century	NN
cord-048487-kamvao4b	126	5	discrepancy	discrepancy	NN
cord-048487-kamvao4b	126	6	suggests	suggest	VBZ
cord-048487-kamvao4b	126	7	that	that	IN
cord-048487-kamvao4b	126	8	the	the	DT
cord-048487-kamvao4b	126	9	subtype	subtype	NN
cord-048487-kamvao4b	126	10	C	C	NNP
cord-048487-kamvao4b	126	11	HA	HA	NNP
cord-048487-kamvao4b	126	12	gene	gene	NN
cord-048487-kamvao4b	126	13	experienced	experience	VBD
cord-048487-kamvao4b	126	14	a	a	DT
cord-048487-kamvao4b	126	15	markedly	markedly	RB
cord-048487-kamvao4b	126	16	different	different	JJ
cord-048487-kamvao4b	126	17	evolutionary	evolutionary	JJ
cord-048487-kamvao4b	126	18	history	history	NN
cord-048487-kamvao4b	126	19	than	than	IN
cord-048487-kamvao4b	126	20	either	either	CC
cord-048487-kamvao4b	126	21	the	the	DT
cord-048487-kamvao4b	126	22	MP	MP	NNP
cord-048487-kamvao4b	126	23	or	or	CC
cord-048487-kamvao4b	126	24	the	the	DT
cord-048487-kamvao4b	126	25	NS	NS	NNP
cord-048487-kamvao4b	126	26	gene	gene	NN
cord-048487-kamvao4b	126	27	.	.	.
cord-048487-kamvao4b	127	1	A	a	DT
cord-048487-kamvao4b	127	2	biologically	biologically	RB
cord-048487-kamvao4b	127	3	plausible	plausible	JJ
cord-048487-kamvao4b	127	4	explanation	explanation	NN
cord-048487-kamvao4b	127	5	would	would	MD
cord-048487-kamvao4b	127	6	be	be	VB
cord-048487-kamvao4b	127	7	a	a	DT
cord-048487-kamvao4b	127	8	reassortment	reassortment	JJ
cord-048487-kamvao4b	127	9	event	event	NN
cord-048487-kamvao4b	127	10	.	.	.
cord-048487-kamvao4b	128	1	Another	another	DT
cord-048487-kamvao4b	128	2	possible	possible	JJ
cord-048487-kamvao4b	128	3	explanation	explanation	NN
cord-048487-kamvao4b	128	4	is	be	VBZ
cord-048487-kamvao4b	128	5	that	that	IN
cord-048487-kamvao4b	128	6	non	non	JJ
cord-048487-kamvao4b	128	7	-	-	JJ
cord-048487-kamvao4b	128	8	MCA	mca	JJ
cord-048487-kamvao4b	128	9	rate	rate	NN
cord-048487-kamvao4b	128	10	behavior	behavior	NN
cord-048487-kamvao4b	128	11	has	have	VBZ
cord-048487-kamvao4b	128	12	lead	lead	NN
cord-048487-kamvao4b	128	13	to	to	IN
cord-048487-kamvao4b	128	14	substantial	substantial	JJ
cord-048487-kamvao4b	128	15	bias	bias	NN
cord-048487-kamvao4b	128	16	in	in	IN
cord-048487-kamvao4b	128	17	dating	date	VBG
cord-048487-kamvao4b	128	18	the	the	DT
cord-048487-kamvao4b	128	19	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	128	20	.	.	.
cord-048487-kamvao4b	129	1	We	-PRON-	PRP
cord-048487-kamvao4b	129	2	now	now	RB
cord-048487-kamvao4b	129	3	compare	compare	VBP
cord-048487-kamvao4b	129	4	the	the	DT
cord-048487-kamvao4b	129	5	results	result	NNS
cord-048487-kamvao4b	129	6	from	from	IN
cord-048487-kamvao4b	129	7	pairwise	pairwise	JJ
cord-048487-kamvao4b	129	8	rate	rate	NN
cord-048487-kamvao4b	129	9	estimates	estimate	NNS
cord-048487-kamvao4b	129	10	across	across	IN
cord-048487-kamvao4b	129	11	subtypes	subtype	NNS
cord-048487-kamvao4b	129	12	A	A	NNP
cord-048487-kamvao4b	129	13	-	-	:
cord-048487-kamvao4b	129	14	H3N2	H3N2	NNP
cord-048487-kamvao4b	129	15	and	and	CC
cord-048487-kamvao4b	129	16	B	B	NNP
cord-048487-kamvao4b	129	17	with	with	IN
cord-048487-kamvao4b	129	18	those	those	DT
cord-048487-kamvao4b	129	19	from	from	IN
cord-048487-kamvao4b	129	20	application	application	NN
cord-048487-kamvao4b	129	21	of	of	IN
cord-048487-kamvao4b	129	22	the	the	DT
cord-048487-kamvao4b	129	23	MCA	MCA	NNP
cord-048487-kamvao4b	129	24	to	to	IN
cord-048487-kamvao4b	129	25	the	the	DT
cord-048487-kamvao4b	129	26	same	same	JJ
cord-048487-kamvao4b	129	27	data	datum	NNS
cord-048487-kamvao4b	129	28	.	.	.
cord-048487-kamvao4b	130	1	These	these	DT
cord-048487-kamvao4b	130	2	results	result	NNS
cord-048487-kamvao4b	130	3	are	be	VBP
cord-048487-kamvao4b	130	4	summarized	summarize	VBN
cord-048487-kamvao4b	130	5	in	in	IN
cord-048487-kamvao4b	130	6	Table	Table	NNP
cord-048487-kamvao4b	130	7	2	2	CD
cord-048487-kamvao4b	130	8	and	and	CC
cord-048487-kamvao4b	130	9	Histograms	Histograms	NNPS
cord-048487-kamvao4b	130	10	of	of	IN
cord-048487-kamvao4b	130	11	the	the	DT
cord-048487-kamvao4b	130	12	time	time	NN
cord-048487-kamvao4b	130	13	of	of	IN
cord-048487-kamvao4b	130	14	most	most	RBS
cord-048487-kamvao4b	130	15	recent	recent	JJ
cord-048487-kamvao4b	130	16	common	common	JJ
cord-048487-kamvao4b	130	17	ancestor	ancestor	NN
cord-048487-kamvao4b	130	18	for	for	IN
cord-048487-kamvao4b	130	19	subtypes	subtype	NNS
cord-048487-kamvao4b	131	1	A	a	LS
cord-048487-kamvao4b	131	2	-	-	:
cord-048487-kamvao4b	131	3	H3N2	H3N2	NNP
cord-048487-kamvao4b	131	4	,	,	,
cord-048487-kamvao4b	131	5	B	B	NNP
cord-048487-kamvao4b	131	6	and	and	CC
cord-048487-kamvao4b	131	7	C	C	NNP
cord-048487-kamvao4b	131	8	,	,	,
cord-048487-kamvao4b	131	9	respectively	respectively	RB
cord-048487-kamvao4b	131	10	,	,	,
cord-048487-kamvao4b	131	11	derived	derive	VBN
cord-048487-kamvao4b	131	12	from	from	IN
cord-048487-kamvao4b	131	13	molecular	molecular	JJ
cord-048487-kamvao4b	131	14	clock	clock	NN
cord-048487-kamvao4b	131	15	estimates	estimate	NNS
cord-048487-kamvao4b	131	16	on	on	IN
cord-048487-kamvao4b	131	17	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	131	18	(	(	-LRB-
cord-048487-kamvao4b	131	19	HA	HA	NNP
cord-048487-kamvao4b	131	20	)	)	-RRB-
cord-048487-kamvao4b	131	21	,	,	,
cord-048487-kamvao4b	131	22	matrix	matrix	NN
cord-048487-kamvao4b	131	23	(	(	-LRB-
cord-048487-kamvao4b	131	24	MP	MP	NNP
cord-048487-kamvao4b	131	25	)	)	-RRB-
cord-048487-kamvao4b	131	26	and	and	CC
cord-048487-kamvao4b	132	1	nonstructural	nonstructural	NNP
cord-048487-kamvao4b	132	2	(	(	-LRB-
cord-048487-kamvao4b	132	3	NS	NS	NNP
cord-048487-kamvao4b	132	4	)	)	-RRB-
cord-048487-kamvao4b	132	5	gene	gene	NN
cord-048487-kamvao4b	132	6	sequences	sequence	NNS
cord-048487-kamvao4b	133	1	This	this	DT
cord-048487-kamvao4b	133	2	discrepancy	discrepancy	NN
cord-048487-kamvao4b	133	3	between	between	IN
cord-048487-kamvao4b	133	4	the	the	DT
cord-048487-kamvao4b	133	5	two	two	CD
cord-048487-kamvao4b	133	6	sets	set	NNS
cord-048487-kamvao4b	133	7	of	of	IN
cord-048487-kamvao4b	133	8	estimates	estimate	NNS
cord-048487-kamvao4b	133	9	of	of	IN
cord-048487-kamvao4b	133	10	the	the	DT
cord-048487-kamvao4b	133	11	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	133	12	likely	likely	RB
cord-048487-kamvao4b	133	13	owes	owe	VBZ
cord-048487-kamvao4b	133	14	to	to	IN
cord-048487-kamvao4b	133	15	the	the	DT
cord-048487-kamvao4b	133	16	inability	inability	NN
cord-048487-kamvao4b	133	17	of	of	IN
cord-048487-kamvao4b	133	18	the	the	DT
cord-048487-kamvao4b	133	19	MCA	MCA	NNP
cord-048487-kamvao4b	133	20	to	to	TO
cord-048487-kamvao4b	133	21	integrate	integrate	VB
cord-048487-kamvao4b	133	22	information	information	NN
cord-048487-kamvao4b	133	23	from	from	IN
cord-048487-kamvao4b	133	24	the	the	DT
cord-048487-kamvao4b	133	25	period	period	NN
cord-048487-kamvao4b	133	26	of	of	IN
cord-048487-kamvao4b	133	27	evolution	evolution	NN
cord-048487-kamvao4b	133	28	between	between	IN
cord-048487-kamvao4b	133	29	the	the	DT
cord-048487-kamvao4b	133	30	two	two	CD
cord-048487-kamvao4b	133	31	subtypes	subtype	NNS
cord-048487-kamvao4b	133	32	,	,	,
cord-048487-kamvao4b	133	33	leading	lead	VBG
cord-048487-kamvao4b	133	34	to	to	IN
cord-048487-kamvao4b	133	35	a	a	DT
cord-048487-kamvao4b	133	36	substantial	substantial	JJ
cord-048487-kamvao4b	133	37	underestimate	underestimate	NN
cord-048487-kamvao4b	133	38	of	of	IN
cord-048487-kamvao4b	133	39	the	the	DT
cord-048487-kamvao4b	133	40	rate	rate	NN
cord-048487-kamvao4b	133	41	of	of	IN
cord-048487-kamvao4b	133	42	substitution	substitution	NN
cord-048487-kamvao4b	133	43	,	,	,
cord-048487-kamvao4b	133	44	and	and	CC
cord-048487-kamvao4b	133	45	consequent	consequent	JJ
cord-048487-kamvao4b	133	46	underestimation	underestimation	NN
cord-048487-kamvao4b	133	47	of	of	IN
cord-048487-kamvao4b	133	48	the	the	DT
cord-048487-kamvao4b	133	49	date	date	NN
cord-048487-kamvao4b	133	50	of	of	IN
cord-048487-kamvao4b	133	51	the	the	DT
cord-048487-kamvao4b	133	52	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	133	53	.	.	.
cord-048487-kamvao4b	134	1	We	-PRON-	PRP
cord-048487-kamvao4b	134	2	present	present	VBP
cord-048487-kamvao4b	134	3	a	a	DT
cord-048487-kamvao4b	134	4	new	new	JJ
cord-048487-kamvao4b	134	5	method	method	NN
cord-048487-kamvao4b	134	6	for	for	IN
cord-048487-kamvao4b	134	7	ascertaining	ascertain	VBG
cord-048487-kamvao4b	134	8	the	the	DT
cord-048487-kamvao4b	134	9	rate	rate	NN
cord-048487-kamvao4b	134	10	of	of	IN
cord-048487-kamvao4b	134	11	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	134	12	substitution	substitution	NN
cord-048487-kamvao4b	134	13	between	between	IN
cord-048487-kamvao4b	134	14	subtypes	subtype	NNS
cord-048487-kamvao4b	134	15	and	and	CC
cord-048487-kamvao4b	134	16	apply	apply	VB
cord-048487-kamvao4b	134	17	this	this	DT
cord-048487-kamvao4b	134	18	method	method	NN
cord-048487-kamvao4b	134	19	together	together	RB
cord-048487-kamvao4b	134	20	with	with	IN
cord-048487-kamvao4b	134	21	traditional	traditional	JJ
cord-048487-kamvao4b	134	22	MCA	MCA	NNP
cord-048487-kamvao4b	134	23	methods	method	NNS
cord-048487-kamvao4b	134	24	to	to	IN
cord-048487-kamvao4b	134	25	date	date	NN
cord-048487-kamvao4b	134	26	the	the	DT
cord-048487-kamvao4b	134	27	divergence	divergence	NN
cord-048487-kamvao4b	134	28	of	of	IN
cord-048487-kamvao4b	134	29	influenza	influenza	NN
cord-048487-kamvao4b	134	30	subtypes	subtype	NNS
cord-048487-kamvao4b	134	31	A	A	NNP
cord-048487-kamvao4b	134	32	-	-	:
cord-048487-kamvao4b	134	33	H3N2	H3N2	NNP
cord-048487-kamvao4b	134	34	,	,	,
cord-048487-kamvao4b	134	35	B	B	NNP
cord-048487-kamvao4b	134	36	,	,	,
cord-048487-kamvao4b	134	37	and	and	CC
cord-048487-kamvao4b	134	38	C.	C.	NNP
cord-048487-kamvao4b	135	1	We	-PRON-	PRP
cord-048487-kamvao4b	135	2	use	use	VBP
cord-048487-kamvao4b	135	3	three	three	CD
cord-048487-kamvao4b	135	4	genes	gene	NNS
cord-048487-kamvao4b	135	5	,	,	,
cord-048487-kamvao4b	135	6	HA	HA	NNP
cord-048487-kamvao4b	135	7	,	,	,
cord-048487-kamvao4b	135	8	MP	MP	NNP
cord-048487-kamvao4b	135	9	and	and	CC
cord-048487-kamvao4b	135	10	NS	NS	NNP
cord-048487-kamvao4b	135	11	,	,	,
cord-048487-kamvao4b	135	12	to	to	IN
cord-048487-kamvao4b	135	13	date	date	NN
cord-048487-kamvao4b	135	14	two	two	CD
cord-048487-kamvao4b	135	15	types	type	NNS
cord-048487-kamvao4b	135	16	of	of	IN
cord-048487-kamvao4b	135	17	divergence	divergence	NN
cord-048487-kamvao4b	135	18	events	event	NNS
cord-048487-kamvao4b	135	19	:	:	:
cord-048487-kamvao4b	135	20	the	the	DT
cord-048487-kamvao4b	135	21	time	time	NN
cord-048487-kamvao4b	135	22	of	of	IN
cord-048487-kamvao4b	135	23	the	the	DT
cord-048487-kamvao4b	135	24	most	most	RBS
cord-048487-kamvao4b	135	25	recent	recent	JJ
cord-048487-kamvao4b	135	26	common	common	NN
cord-048487-kamvao4b	135	27	of	of	IN
cord-048487-kamvao4b	135	28	each	each	DT
cord-048487-kamvao4b	135	29	subtype	subtype	NN
cord-048487-kamvao4b	135	30	and	and	CC
cord-048487-kamvao4b	135	31	the	the	DT
cord-048487-kamvao4b	135	32	time	time	NN
cord-048487-kamvao4b	135	33	of	of	IN
cord-048487-kamvao4b	135	34	divergence	divergence	NN
cord-048487-kamvao4b	135	35	between	between	IN
cord-048487-kamvao4b	135	36	two	two	CD
cord-048487-kamvao4b	135	37	subtypes	subtype	NNS
cord-048487-kamvao4b	135	38	,	,	,
cord-048487-kamvao4b	135	39	A	A	NNP
cord-048487-kamvao4b	135	40	-	-	HYPH
cord-048487-kamvao4b	135	41	H3N2	H3N2	NNP
cord-048487-kamvao4b	135	42	and	and	CC
cord-048487-kamvao4b	135	43	B.	B.	NNP
cord-048487-kamvao4b	136	1	For	for	IN
cord-048487-kamvao4b	136	2	the	the	DT
cord-048487-kamvao4b	136	3	former	former	JJ
cord-048487-kamvao4b	136	4	event	event	NN
cord-048487-kamvao4b	136	5	type	type	NN
cord-048487-kamvao4b	136	6	,	,	,
cord-048487-kamvao4b	136	7	we	-PRON-	PRP
cord-048487-kamvao4b	136	8	show	show	VBP
cord-048487-kamvao4b	136	9	that	that	IN
cord-048487-kamvao4b	136	10	the	the	DT
cord-048487-kamvao4b	136	11	three	three	CD
cord-048487-kamvao4b	136	12	genes	gene	NNS
cord-048487-kamvao4b	136	13	are	be	VBP
cord-048487-kamvao4b	136	14	loosely	loosely	RB
cord-048487-kamvao4b	136	15	consistent	consistent	JJ
cord-048487-kamvao4b	136	16	in	in	IN
cord-048487-kamvao4b	136	17	their	-PRON-	PRP$
cord-048487-kamvao4b	136	18	dating	dating	NN
cord-048487-kamvao4b	136	19	of	of	IN
cord-048487-kamvao4b	136	20	the	the	DT
cord-048487-kamvao4b	136	21	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	136	22	of	of	IN
cord-048487-kamvao4b	136	23	the	the	DT
cord-048487-kamvao4b	136	24	subtypes	subtype	NNS
cord-048487-kamvao4b	136	25	,	,	,
cord-048487-kamvao4b	136	26	with	with	IN
cord-048487-kamvao4b	136	27	the	the	DT
cord-048487-kamvao4b	136	28	notable	notable	JJ
cord-048487-kamvao4b	136	29	exception	exception	NN
cord-048487-kamvao4b	136	30	of	of	IN
cord-048487-kamvao4b	136	31	the	the	DT
cord-048487-kamvao4b	136	32	HA	HA	NNP
cord-048487-kamvao4b	136	33	-	-	HYPH
cord-048487-kamvao4b	136	34	derived	derive	VBN
cord-048487-kamvao4b	136	35	estimate	estimate	NN
cord-048487-kamvao4b	136	36	of	of	IN
cord-048487-kamvao4b	136	37	subtype	subtype	NN
cord-048487-kamvao4b	136	38	C	C	NNP
cord-048487-kamvao4b	136	39	's	's	POS
cord-048487-kamvao4b	136	40	TMRCA	TMRCA	NNP
cord-048487-kamvao4b	136	41	approximately	approximately	RB
cord-048487-kamvao4b	136	42	50	50	CD
cord-048487-kamvao4b	136	43	years	year	NNS
cord-048487-kamvao4b	136	44	before	before	IN
cord-048487-kamvao4b	136	45	the	the	DT
cord-048487-kamvao4b	136	46	MP	MP	NNP
cord-048487-kamvao4b	136	47	-	-	:
cord-048487-kamvao4b	136	48	and	and	CC
cord-048487-kamvao4b	136	49	NS	NS	NNP
cord-048487-kamvao4b	136	50	-	-	HYPH
cord-048487-kamvao4b	136	51	derived	derive	VBN
cord-048487-kamvao4b	136	52	estimates	estimate	NNS
cord-048487-kamvao4b	136	53	.	.	.
cord-048487-kamvao4b	137	1	This	this	DT
cord-048487-kamvao4b	137	2	discrepancy	discrepancy	NN
cord-048487-kamvao4b	137	3	may	may	MD
cord-048487-kamvao4b	137	4	indicate	indicate	VB
cord-048487-kamvao4b	137	5	either	either	CC
cord-048487-kamvao4b	137	6	that	that	IN
cord-048487-kamvao4b	137	7	subtype	subtype	NN
cord-048487-kamvao4b	137	8	C	C	NNP
cord-048487-kamvao4b	137	9	's	's	POS
cord-048487-kamvao4b	137	10	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	137	11	-	-	HYPH
cord-048487-kamvao4b	137	12	esterase	esterase	NN
cord-048487-kamvao4b	137	13	gene	gene	NN
cord-048487-kamvao4b	137	14	engaged	engage	VBN
cord-048487-kamvao4b	137	15	in	in	IN
cord-048487-kamvao4b	137	16	a	a	DT
cord-048487-kamvao4b	137	17	biologically	biologically	RB
cord-048487-kamvao4b	137	18	significant	significant	JJ
cord-048487-kamvao4b	137	19	event	event	NN
cord-048487-kamvao4b	137	20	,	,	,
cord-048487-kamvao4b	137	21	such	such	JJ
cord-048487-kamvao4b	137	22	as	as	IN
cord-048487-kamvao4b	137	23	reassortment	reassortment	NN
cord-048487-kamvao4b	137	24	,	,	,
cord-048487-kamvao4b	137	25	or	or	CC
cord-048487-kamvao4b	137	26	that	that	IN
cord-048487-kamvao4b	137	27	MCA	MCA	NNP
cord-048487-kamvao4b	137	28	estimation	estimation	NN
cord-048487-kamvao4b	137	29	does	do	VBZ
cord-048487-kamvao4b	137	30	not	not	RB
cord-048487-kamvao4b	137	31	adequately	adequately	RB
cord-048487-kamvao4b	137	32	model	model	VB
cord-048487-kamvao4b	137	33	the	the	DT
cord-048487-kamvao4b	137	34	evolution	evolution	NN
cord-048487-kamvao4b	137	35	of	of	IN
cord-048487-kamvao4b	137	36	the	the	DT
cord-048487-kamvao4b	137	37	gene	gene	NN
cord-048487-kamvao4b	137	38	.	.	.
cord-048487-kamvao4b	138	1	For	for	IN
cord-048487-kamvao4b	138	2	the	the	DT
cord-048487-kamvao4b	138	3	divergence	divergence	NN
cord-048487-kamvao4b	138	4	between	between	IN
cord-048487-kamvao4b	138	5	subtypes	subtype	NNS
cord-048487-kamvao4b	138	6	A	A	NNP
cord-048487-kamvao4b	138	7	-	-	:
cord-048487-kamvao4b	138	8	H3N2	H3N2	NNP
cord-048487-kamvao4b	138	9	and	and	CC
cord-048487-kamvao4b	138	10	B	B	NNP
cord-048487-kamvao4b	138	11	,	,	,
cord-048487-kamvao4b	138	12	previous	previous	JJ
cord-048487-kamvao4b	138	13	studies	study	NNS
cord-048487-kamvao4b	138	14	using	use	VBG
cord-048487-kamvao4b	138	15	the	the	DT
cord-048487-kamvao4b	138	16	MCA	MCA	NNP
cord-048487-kamvao4b	138	17	generally	generally	RB
cord-048487-kamvao4b	138	18	place	place	VBP
cord-048487-kamvao4b	138	19	a	a	DT
cord-048487-kamvao4b	138	20	time	time	NN
cord-048487-kamvao4b	138	21	of	of	IN
cord-048487-kamvao4b	138	22	divergence	divergence	NN
cord-048487-kamvao4b	138	23	of	of	IN
cord-048487-kamvao4b	138	24	several	several	JJ
cord-048487-kamvao4b	138	25	hundred	hundred	CD
cord-048487-kamvao4b	138	26	years	year	NNS
cord-048487-kamvao4b	138	27	ago	ago	RB
cord-048487-kamvao4b	138	28	,	,	,
cord-048487-kamvao4b	138	29	ranging	range	VBG
cord-048487-kamvao4b	138	30	from	from	IN
cord-048487-kamvao4b	138	31	the	the	DT
cord-048487-kamvao4b	138	32	16th	16th	NN
cord-048487-kamvao4b	138	33	to	to	IN
cord-048487-kamvao4b	138	34	early	early	JJ
cord-048487-kamvao4b	138	35	19th	19th	JJ
cord-048487-kamvao4b	138	36	centuries	century	NNS
cord-048487-kamvao4b	138	37	.	.	.
cord-048487-kamvao4b	139	1	Other	other	JJ
cord-048487-kamvao4b	139	2	analysis	analysis	NN
cord-048487-kamvao4b	139	3	have	have	VBP
cord-048487-kamvao4b	139	4	yielded	yield	VBN
cord-048487-kamvao4b	139	5	estimates	estimate	NNS
cord-048487-kamvao4b	139	6	of	of	IN
cord-048487-kamvao4b	139	7	3600	3600	CD
cord-048487-kamvao4b	139	8	years	year	NNS
cord-048487-kamvao4b	139	9	ago	ago	RB
cord-048487-kamvao4b	139	10	[	[	-LRB-
cord-048487-kamvao4b	139	11	23	23	CD
cord-048487-kamvao4b	139	12	]	]	-RRB-
cord-048487-kamvao4b	139	13	.	.	.
cord-048487-kamvao4b	140	1	In	in	IN
cord-048487-kamvao4b	140	2	the	the	DT
cord-048487-kamvao4b	140	3	current	current	JJ
cord-048487-kamvao4b	140	4	study	study	NN
cord-048487-kamvao4b	140	5	,	,	,
cord-048487-kamvao4b	140	6	application	application	NN
cord-048487-kamvao4b	140	7	of	of	IN
cord-048487-kamvao4b	140	8	the	the	DT
cord-048487-kamvao4b	140	9	MCA	MCA	NNP
cord-048487-kamvao4b	140	10	yielded	yield	VBD
cord-048487-kamvao4b	140	11	estimates	estimate	NNS
cord-048487-kamvao4b	140	12	in	in	IN
cord-048487-kamvao4b	140	13	the	the	DT
cord-048487-kamvao4b	140	14	last	last	JJ
cord-048487-kamvao4b	140	15	half	half	NN
cord-048487-kamvao4b	140	16	of	of	IN
cord-048487-kamvao4b	140	17	the	the	DT
cord-048487-kamvao4b	140	18	18th	18th	JJ
cord-048487-kamvao4b	140	19	century	century	NN
cord-048487-kamvao4b	140	20	.	.	.
cord-048487-kamvao4b	141	1	However	however	RB
cord-048487-kamvao4b	141	2	,	,	,
cord-048487-kamvao4b	141	3	applying	apply	VBG
cord-048487-kamvao4b	141	4	the	the	DT
cord-048487-kamvao4b	141	5	pairwise	pairwise	JJ
cord-048487-kamvao4b	141	6	rate	rate	NN
cord-048487-kamvao4b	141	7	estimate	estimate	NN
cord-048487-kamvao4b	141	8	developed	develop	VBN
cord-048487-kamvao4b	141	9	above	above	IN
cord-048487-kamvao4b	141	10	we	-PRON-	PRP
cord-048487-kamvao4b	141	11	find	find	VBP
cord-048487-kamvao4b	141	12	uniformly	uniformly	RB
cord-048487-kamvao4b	141	13	,	,	,
cord-048487-kamvao4b	141	14	across	across	IN
cord-048487-kamvao4b	141	15	genes	gene	NNS
cord-048487-kamvao4b	141	16	,	,	,
cord-048487-kamvao4b	141	17	that	that	IN
cord-048487-kamvao4b	141	18	the	the	DT
cord-048487-kamvao4b	141	19	divergence	divergence	NN
cord-048487-kamvao4b	141	20	likely	likely	RB
cord-048487-kamvao4b	141	21	occurred	occur	VBD
cord-048487-kamvao4b	141	22	in	in	IN
cord-048487-kamvao4b	141	23	the	the	DT
cord-048487-kamvao4b	141	24	very	very	RB
cord-048487-kamvao4b	141	25	early	early	JJ
cord-048487-kamvao4b	141	26	20th	20th	JJ
cord-048487-kamvao4b	141	27	century	century	NN
cord-048487-kamvao4b	141	28	.	.	.
cord-048487-kamvao4b	142	1	The	the	DT
cord-048487-kamvao4b	142	2	discrepancy	discrepancy	NN
cord-048487-kamvao4b	142	3	between	between	IN
cord-048487-kamvao4b	142	4	these	these	DT
cord-048487-kamvao4b	142	5	two	two	CD
cord-048487-kamvao4b	142	6	measures	measure	NNS
cord-048487-kamvao4b	142	7	is	be	VBZ
cord-048487-kamvao4b	142	8	likely	likely	JJ
cord-048487-kamvao4b	142	9	due	due	IN
cord-048487-kamvao4b	142	10	to	to	IN
cord-048487-kamvao4b	142	11	the	the	DT
cord-048487-kamvao4b	142	12	increased	increase	VBN
cord-048487-kamvao4b	142	13	modeling	modeling	NN
cord-048487-kamvao4b	142	14	flexibility	flexibility	NN
cord-048487-kamvao4b	142	15	of	of	IN
cord-048487-kamvao4b	142	16	the	the	DT
cord-048487-kamvao4b	142	17	pairwise	pairwise	JJ
cord-048487-kamvao4b	142	18	rate	rate	NN
cord-048487-kamvao4b	142	19	estimate	estimate	NN
cord-048487-kamvao4b	142	20	relative	relative	JJ
cord-048487-kamvao4b	142	21	to	to	IN
cord-048487-kamvao4b	142	22	the	the	DT
cord-048487-kamvao4b	142	23	MCA	MCA	NNP
cord-048487-kamvao4b	142	24	.	.	.
cord-048487-kamvao4b	143	1	This	this	DT
cord-048487-kamvao4b	143	2	discrepancy	discrepancy	NN
cord-048487-kamvao4b	143	3	between	between	IN
cord-048487-kamvao4b	143	4	the	the	DT
cord-048487-kamvao4b	143	5	rates	rate	NNS
cord-048487-kamvao4b	143	6	and	and	CC
cord-048487-kamvao4b	143	7	corresponding	correspond	VBG
cord-048487-kamvao4b	143	8	TMCRA	TMCRA	NNP
cord-048487-kamvao4b	143	9	estimates	estimate	NNS
cord-048487-kamvao4b	143	10	has	have	VBZ
cord-048487-kamvao4b	143	11	important	important	JJ
cord-048487-kamvao4b	143	12	biological	biological	JJ
cord-048487-kamvao4b	143	13	consequence	consequence	NN
cord-048487-kamvao4b	143	14	.	.	.
cord-048487-kamvao4b	144	1	The	the	DT
cord-048487-kamvao4b	144	2	phylogenetic	phylogenetic	JJ
cord-048487-kamvao4b	144	3	divergence	divergence	NN
cord-048487-kamvao4b	144	4	between	between	IN
cord-048487-kamvao4b	144	5	subtype	subtype	NN
cord-048487-kamvao4b	144	6	A	a	NN
cord-048487-kamvao4b	144	7	-	-	:
cord-048487-kamvao4b	144	8	H3N2	H3N2	NNP
cord-048487-kamvao4b	144	9	and	and	CC
cord-048487-kamvao4b	144	10	B	B	NNP
cord-048487-kamvao4b	144	11	corresponds	correspond	VBZ
cord-048487-kamvao4b	144	12	to	to	IN
cord-048487-kamvao4b	144	13	a	a	DT
cord-048487-kamvao4b	144	14	subspeciation	subspeciation	NN
cord-048487-kamvao4b	144	15	event	event	NN
cord-048487-kamvao4b	144	16	for	for	IN
cord-048487-kamvao4b	144	17	the	the	DT
cord-048487-kamvao4b	144	18	virus	virus	NN
cord-048487-kamvao4b	144	19	.	.	.
cord-048487-kamvao4b	145	1	The	the	DT
cord-048487-kamvao4b	145	2	results	result	NNS
cord-048487-kamvao4b	145	3	in	in	IN
cord-048487-kamvao4b	145	4	this	this	DT
cord-048487-kamvao4b	145	5	study	study	NN
cord-048487-kamvao4b	145	6	indicate	indicate	VBP
cord-048487-kamvao4b	145	7	that	that	IN
cord-048487-kamvao4b	145	8	the	the	DT
cord-048487-kamvao4b	145	9	process	process	NN
cord-048487-kamvao4b	145	10	of	of	IN
cord-048487-kamvao4b	145	11	speciation	speciation	NN
cord-048487-kamvao4b	145	12	is	be	VBZ
cord-048487-kamvao4b	145	13	not	not	RB
cord-048487-kamvao4b	145	14	neutral	neutral	JJ
cord-048487-kamvao4b	145	15	but	but	CC
cord-048487-kamvao4b	145	16	instead	instead	RB
cord-048487-kamvao4b	145	17	a	a	DT
cord-048487-kamvao4b	145	18	period	period	NN
cord-048487-kamvao4b	145	19	of	of	IN
cord-048487-kamvao4b	145	20	rapid	rapid	JJ
cord-048487-kamvao4b	145	21	and	and	CC
cord-048487-kamvao4b	145	22	intense	intense	JJ
cord-048487-kamvao4b	145	23	genetic	genetic	JJ
cord-048487-kamvao4b	145	24	change	change	NN
cord-048487-kamvao4b	145	25	.	.	.
cord-048487-kamvao4b	146	1	The	the	DT
cord-048487-kamvao4b	146	2	three	three	CD
cord-048487-kamvao4b	146	3	genes	gene	NNS
cord-048487-kamvao4b	146	4	studied	study	VBN
cord-048487-kamvao4b	146	5	here	here	RB
cord-048487-kamvao4b	146	6	consistently	consistently	RB
cord-048487-kamvao4b	146	7	show	show	VBP
cord-048487-kamvao4b	146	8	large	large	JJ
cord-048487-kamvao4b	146	9	acceleration	acceleration	NN
cord-048487-kamvao4b	146	10	in	in	IN
cord-048487-kamvao4b	146	11	the	the	DT
cord-048487-kamvao4b	146	12	rate	rate	NN
cord-048487-kamvao4b	146	13	of	of	IN
cord-048487-kamvao4b	146	14	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	146	15	substitution	substitution	NN
cord-048487-kamvao4b	146	16	for	for	IN
cord-048487-kamvao4b	146	17	the	the	DT
cord-048487-kamvao4b	146	18	divergence	divergence	NN
cord-048487-kamvao4b	146	19	period	period	NN
cord-048487-kamvao4b	146	20	relative	relative	JJ
cord-048487-kamvao4b	146	21	to	to	IN
cord-048487-kamvao4b	146	22	the	the	DT
cord-048487-kamvao4b	146	23	rates	rate	NNS
cord-048487-kamvao4b	146	24	observed	observe	VBN
cord-048487-kamvao4b	146	25	within	within	IN
cord-048487-kamvao4b	146	26	a	a	DT
cord-048487-kamvao4b	146	27	stable	stable	JJ
cord-048487-kamvao4b	146	28	subtype	subtype	NN
cord-048487-kamvao4b	146	29	.	.	.
cord-048487-kamvao4b	147	1	This	this	DT
cord-048487-kamvao4b	147	2	study	study	NN
cord-048487-kamvao4b	147	3	gives	give	VBZ
cord-048487-kamvao4b	147	4	strong	strong	JJ
cord-048487-kamvao4b	147	5	evidence	evidence	NN
cord-048487-kamvao4b	147	6	that	that	IN
cord-048487-kamvao4b	147	7	,	,	,
cord-048487-kamvao4b	147	8	at	at	IN
cord-048487-kamvao4b	147	9	least	least	JJS
cord-048487-kamvao4b	147	10	for	for	IN
cord-048487-kamvao4b	147	11	influenza	influenza	JJ
cord-048487-kamvao4b	147	12	viral	viral	JJ
cord-048487-kamvao4b	147	13	subtype	subtype	NN
cord-048487-kamvao4b	147	14	divergence	divergence	NN
cord-048487-kamvao4b	147	15	,	,	,
cord-048487-kamvao4b	147	16	the	the	DT
cord-048487-kamvao4b	147	17	process	process	NN
cord-048487-kamvao4b	147	18	of	of	IN
cord-048487-kamvao4b	147	19	subspeciation	subspeciation	NN
cord-048487-kamvao4b	147	20	is	be	VBZ
cord-048487-kamvao4b	147	21	associated	associate	VBN
cord-048487-kamvao4b	147	22	not	not	RB
cord-048487-kamvao4b	147	23	just	just	RB
cord-048487-kamvao4b	147	24	with	with	IN
cord-048487-kamvao4b	147	25	large	large	JJ
cord-048487-kamvao4b	147	26	genomic	genomic	JJ
cord-048487-kamvao4b	147	27	changes	change	NNS
cord-048487-kamvao4b	147	28	but	but	CC
cord-048487-kamvao4b	147	29	also	also	RB
cord-048487-kamvao4b	147	30	with	with	IN
cord-048487-kamvao4b	147	31	an	an	DT
cord-048487-kamvao4b	147	32	accelerated	accelerated	JJ
cord-048487-kamvao4b	147	33	,	,	,
cord-048487-kamvao4b	147	34	finite	finite	JJ
cord-048487-kamvao4b	147	35	process	process	NN
cord-048487-kamvao4b	147	36	of	of	IN
cord-048487-kamvao4b	147	37	adaption	adaption	NN
cord-048487-kamvao4b	147	38	.	.	.
cord-048487-kamvao4b	148	1	Histograms	Histograms	NNP
cord-048487-kamvao4b	148	2	of	of	IN
cord-048487-kamvao4b	148	3	the	the	DT
cord-048487-kamvao4b	148	4	time	time	NN
cord-048487-kamvao4b	148	5	of	of	IN
cord-048487-kamvao4b	148	6	most	most	RBS
cord-048487-kamvao4b	148	7	recent	recent	JJ
cord-048487-kamvao4b	148	8	common	common	JJ
cord-048487-kamvao4b	148	9	ancestor	ancestor	NN
cord-048487-kamvao4b	148	10	of	of	IN
cord-048487-kamvao4b	148	11	subtypes	subtype	NNS
cord-048487-kamvao4b	148	12	A	A	NNP
cord-048487-kamvao4b	148	13	-	-	:
cord-048487-kamvao4b	148	14	H3N2	H3N2	NNP
cord-048487-kamvao4b	148	15	and	and	CC
cord-048487-kamvao4b	148	16	B	B	NNP
cord-048487-kamvao4b	148	17	,	,	,
cord-048487-kamvao4b	148	18	derived	derive	VBN
cord-048487-kamvao4b	148	19	from	from	IN
cord-048487-kamvao4b	148	20	molecular	molecular	JJ
cord-048487-kamvao4b	148	21	clock	clock	NN
cord-048487-kamvao4b	148	22	estimates	estimate	NNS
cord-048487-kamvao4b	148	23	(	(	-LRB-
cord-048487-kamvao4b	148	24	light	light	JJ
cord-048487-kamvao4b	148	25	grey	grey	NN
cord-048487-kamvao4b	148	26	)	)	-RRB-
cord-048487-kamvao4b	148	27	and	and	CC
cord-048487-kamvao4b	148	28	pairwise	pairwise	JJ
cord-048487-kamvao4b	148	29	estimates	estimate	NNS
cord-048487-kamvao4b	148	30	(	(	-LRB-
cord-048487-kamvao4b	148	31	dark	dark	NNP
cord-048487-kamvao4b	148	32	grey	grey	NNP
cord-048487-kamvao4b	148	33	)	)	-RRB-
cord-048487-kamvao4b	148	34	on	on	IN
cord-048487-kamvao4b	148	35	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	148	36	(	(	-LRB-
cord-048487-kamvao4b	148	37	HA	HA	NNP
cord-048487-kamvao4b	148	38	)	)	-RRB-
cord-048487-kamvao4b	148	39	,	,	,
cord-048487-kamvao4b	148	40	matrix	matrix	NN
cord-048487-kamvao4b	148	41	(	(	-LRB-
cord-048487-kamvao4b	148	42	MP	MP	NNP
cord-048487-kamvao4b	148	43	)	)	-RRB-
cord-048487-kamvao4b	148	44	and	and	CC
cord-048487-kamvao4b	148	45	nonstructural	nonstructural	JJ
cord-048487-kamvao4b	148	46	(	(	-LRB-
cord-048487-kamvao4b	148	47	NS	NS	NNP
cord-048487-kamvao4b	148	48	)	)	-RRB-
cord-048487-kamvao4b	148	49	gene	gene	NN
cord-048487-kamvao4b	148	50	sequences	sequence	NNS
cord-048487-kamvao4b	148	51	Assuming	assume	VBG
cord-048487-kamvao4b	148	52	that	that	IN
cord-048487-kamvao4b	148	53	the	the	DT
cord-048487-kamvao4b	148	54	more	more	RBR
cord-048487-kamvao4b	148	55	recent	recent	JJ
cord-048487-kamvao4b	148	56	estimate	estimate	NN
cord-048487-kamvao4b	148	57	is	be	VBZ
cord-048487-kamvao4b	148	58	correct	correct	JJ
cord-048487-kamvao4b	148	59	,	,	,
cord-048487-kamvao4b	148	60	a	a	DT
cord-048487-kamvao4b	148	61	subsequent	subsequent	JJ
cord-048487-kamvao4b	148	62	question	question	NN
cord-048487-kamvao4b	148	63	is	be	VBZ
cord-048487-kamvao4b	148	64	whether	whether	IN
cord-048487-kamvao4b	148	65	or	or	CC
cord-048487-kamvao4b	148	66	not	not	RB
cord-048487-kamvao4b	148	67	a	a	DT
cord-048487-kamvao4b	148	68	pandemic	pandemic	NN
cord-048487-kamvao4b	148	69	or	or	CC
cord-048487-kamvao4b	148	70	epidemic	epidemic	NN
cord-048487-kamvao4b	148	71	associates	associate	NNS
cord-048487-kamvao4b	148	72	with	with	IN
cord-048487-kamvao4b	148	73	subtype	subtype	NN
cord-048487-kamvao4b	148	74	A	A	NNP
cord-048487-kamvao4b	148	75	-	-	:
cord-048487-kamvao4b	148	76	H3N2	H3N2	NNP
cord-048487-kamvao4b	148	77	/	/	SYM
cord-048487-kamvao4b	148	78	B	b	NN
cord-048487-kamvao4b	148	79	divergence	divergence	NN
cord-048487-kamvao4b	148	80	.	.	.
cord-048487-kamvao4b	149	1	In	in	IN
cord-048487-kamvao4b	149	2	the	the	DT
cord-048487-kamvao4b	149	3	twentieth	twentieth	JJ
cord-048487-kamvao4b	149	4	century	century	NN
cord-048487-kamvao4b	149	5	,	,	,
cord-048487-kamvao4b	149	6	all	all	DT
cord-048487-kamvao4b	149	7	influenza	influenza	NN
cord-048487-kamvao4b	149	8	pandemics	pandemic	NNS
cord-048487-kamvao4b	149	9	associate	associate	VBP
cord-048487-kamvao4b	149	10	with	with	IN
cord-048487-kamvao4b	149	11	the	the	DT
cord-048487-kamvao4b	149	12	emergence	emergence	NN
cord-048487-kamvao4b	149	13	or	or	CC
cord-048487-kamvao4b	149	14	reemergence	reemergence	NN
cord-048487-kamvao4b	149	15	of	of	IN
cord-048487-kamvao4b	149	16	subtypes	subtype	NNS
cord-048487-kamvao4b	149	17	(	(	-LRB-
cord-048487-kamvao4b	149	18	A	A	NNP
cord-048487-kamvao4b	149	19	-	-	HYPH
cord-048487-kamvao4b	149	20	H1N1	H1N1	NNP
cord-048487-kamvao4b	149	21	in	in	IN
cord-048487-kamvao4b	149	22	1918	1918	CD
cord-048487-kamvao4b	149	23	,	,	,
cord-048487-kamvao4b	149	24	A	A	NNP
cord-048487-kamvao4b	149	25	-	-	:
cord-048487-kamvao4b	149	26	H2N2	H2N2	NNP
cord-048487-kamvao4b	149	27	in	in	IN
cord-048487-kamvao4b	149	28	1957	1957	CD
cord-048487-kamvao4b	149	29	and	and	CC
cord-048487-kamvao4b	149	30	A	A	NNP
cord-048487-kamvao4b	149	31	-	-	:
cord-048487-kamvao4b	149	32	H3N2	H3N2	NNP
cord-048487-kamvao4b	149	33	in	in	IN
cord-048487-kamvao4b	149	34	1968	1968	CD
cord-048487-kamvao4b	149	35	)	)	-RRB-
cord-048487-kamvao4b	149	36	.	.	.
cord-048487-kamvao4b	150	1	Serological	serological	JJ
cord-048487-kamvao4b	150	2	analysis	analysis	NN
cord-048487-kamvao4b	150	3	indicates	indicate	VBZ
cord-048487-kamvao4b	150	4	that	that	IN
cord-048487-kamvao4b	150	5	the	the	DT
cord-048487-kamvao4b	150	6	1897	1897	CD
cord-048487-kamvao4b	150	7	pandemic	pandemic	NN
cord-048487-kamvao4b	150	8	was	be	VBD
cord-048487-kamvao4b	150	9	likely	likely	JJ
cord-048487-kamvao4b	150	10	due	due	IN
cord-048487-kamvao4b	150	11	to	to	IN
cord-048487-kamvao4b	150	12	subtype	subtype	NN
cord-048487-kamvao4b	150	13	A	A	NNP
cord-048487-kamvao4b	150	14	-	-	:
cord-048487-kamvao4b	150	15	H2N2	H2N2	NNP
cord-048487-kamvao4b	150	16	.	.	.
cord-048487-kamvao4b	151	1	However	however	RB
cord-048487-kamvao4b	151	2	,	,	,
cord-048487-kamvao4b	151	3	the	the	DT
cord-048487-kamvao4b	151	4	pandemic	pandemic	NN
cord-048487-kamvao4b	151	5	of	of	IN
cord-048487-kamvao4b	151	6	1900	1900	CD
cord-048487-kamvao4b	151	7	is	be	VBZ
cord-048487-kamvao4b	151	8	of	of	IN
cord-048487-kamvao4b	151	9	uncertain	uncertain	JJ
cord-048487-kamvao4b	151	10	type	type	NN
cord-048487-kamvao4b	151	11	,	,	,
cord-048487-kamvao4b	151	12	although	although	IN
cord-048487-kamvao4b	151	13	it	-PRON-	PRP
cord-048487-kamvao4b	151	14	is	be	VBZ
cord-048487-kamvao4b	151	15	commonly	commonly	RB
cord-048487-kamvao4b	151	16	reported	report	VBN
cord-048487-kamvao4b	151	17	in	in	IN
cord-048487-kamvao4b	151	18	the	the	DT
cord-048487-kamvao4b	151	19	literature	literature	NN
cord-048487-kamvao4b	151	20	as	as	IN
cord-048487-kamvao4b	151	21	being	be	VBG
cord-048487-kamvao4b	151	22	due	due	JJ
cord-048487-kamvao4b	151	23	to	to	IN
cord-048487-kamvao4b	151	24	A	a	DT
cord-048487-kamvao4b	151	25	-	-	:
cord-048487-kamvao4b	151	26	H3N2	H3N2	NNP
cord-048487-kamvao4b	151	27	[	[	-LRB-
cord-048487-kamvao4b	151	28	4	4	CD
cord-048487-kamvao4b	151	29	]	]	-RRB-
cord-048487-kamvao4b	151	30	.	.	.
cord-048487-kamvao4b	152	1	The	the	DT
cord-048487-kamvao4b	152	2	above	above	JJ
cord-048487-kamvao4b	152	3	analysis	analysis	NN
cord-048487-kamvao4b	152	4	suggests	suggest	VBZ
cord-048487-kamvao4b	152	5	that	that	IN
cord-048487-kamvao4b	152	6	it	-PRON-	PRP
cord-048487-kamvao4b	152	7	is	be	VBZ
cord-048487-kamvao4b	152	8	possible	possible	JJ
cord-048487-kamvao4b	152	9	to	to	TO
cord-048487-kamvao4b	152	10	postulate	postulate	VB
cord-048487-kamvao4b	152	11	that	that	IN
cord-048487-kamvao4b	152	12	the	the	DT
cord-048487-kamvao4b	152	13	cause	cause	NN
cord-048487-kamvao4b	152	14	of	of	IN
cord-048487-kamvao4b	152	15	this	this	DT
cord-048487-kamvao4b	152	16	pandemic	pandemic	NN
cord-048487-kamvao4b	152	17	is	be	VBZ
cord-048487-kamvao4b	152	18	due	due	JJ
cord-048487-kamvao4b	152	19	to	to	IN
cord-048487-kamvao4b	152	20	the	the	DT
cord-048487-kamvao4b	152	21	emergence	emergence	NN
cord-048487-kamvao4b	152	22	of	of	IN
cord-048487-kamvao4b	152	23	subtype	subtype	NN
cord-048487-kamvao4b	152	24	A	a	NN
cord-048487-kamvao4b	152	25	-	-	:
cord-048487-kamvao4b	152	26	H3N2	H3N2	NNP
cord-048487-kamvao4b	152	27	or	or	CC
cord-048487-kamvao4b	152	28	B.	B.	NNP
cord-048487-kamvao4b	153	1	As	as	IN
cord-048487-kamvao4b	153	2	noted	note	VBN
cord-048487-kamvao4b	153	3	above	above	RB
cord-048487-kamvao4b	153	4	,	,	,
cord-048487-kamvao4b	153	5	we	-PRON-	PRP
cord-048487-kamvao4b	153	6	condition	condition	VBP
cord-048487-kamvao4b	153	7	the	the	DT
cord-048487-kamvao4b	153	8	results	result	NNS
cord-048487-kamvao4b	153	9	presented	present	VBN
cord-048487-kamvao4b	153	10	here	here	RB
cord-048487-kamvao4b	153	11	on	on	IN
cord-048487-kamvao4b	153	12	a	a	DT
cord-048487-kamvao4b	153	13	specific	specific	JJ
cord-048487-kamvao4b	153	14	sequence	sequence	NN
cord-048487-kamvao4b	153	15	alignment	alignment	NN
cord-048487-kamvao4b	153	16	.	.	.
cord-048487-kamvao4b	154	1	As	as	IN
cord-048487-kamvao4b	154	2	the	the	DT
cord-048487-kamvao4b	154	3	question	question	NN
cord-048487-kamvao4b	154	4	under	under	IN
cord-048487-kamvao4b	154	5	consideration	consideration	NN
cord-048487-kamvao4b	154	6	concerns	concern	VBZ
cord-048487-kamvao4b	154	7	the	the	DT
cord-048487-kamvao4b	154	8	divergence	divergence	NN
cord-048487-kamvao4b	154	9	of	of	IN
cord-048487-kamvao4b	154	10	specific	specific	JJ
cord-048487-kamvao4b	154	11	genes	gene	NNS
cord-048487-kamvao4b	154	12	and	and	CC
cord-048487-kamvao4b	154	13	proteins	protein	NNS
cord-048487-kamvao4b	154	14	over	over	IN
cord-048487-kamvao4b	154	15	a	a	DT
cord-048487-kamvao4b	154	16	(	(	-LRB-
cord-048487-kamvao4b	154	17	presumably	presumably	RB
cord-048487-kamvao4b	154	18	)	)	-RRB-
cord-048487-kamvao4b	154	19	long	long	JJ
cord-048487-kamvao4b	154	20	time	time	NN
cord-048487-kamvao4b	154	21	scale	scale	NN
cord-048487-kamvao4b	154	22	,	,	,
cord-048487-kamvao4b	154	23	the	the	DT
cord-048487-kamvao4b	154	24	capacity	capacity	NN
cord-048487-kamvao4b	154	25	to	to	TO
cord-048487-kamvao4b	154	26	generate	generate	VB
cord-048487-kamvao4b	154	27	reasonable	reasonable	JJ
cord-048487-kamvao4b	154	28	alignments	alignment	NNS
cord-048487-kamvao4b	154	29	diminishes	diminish	VBZ
cord-048487-kamvao4b	154	30	with	with	IN
cord-048487-kamvao4b	154	31	increasing	increase	VBG
cord-048487-kamvao4b	154	32	time	time	NN
cord-048487-kamvao4b	154	33	of	of	IN
cord-048487-kamvao4b	154	34	divergence	divergence	NN
cord-048487-kamvao4b	154	35	between	between	IN
cord-048487-kamvao4b	154	36	types	type	NNS
cord-048487-kamvao4b	154	37	,	,	,
cord-048487-kamvao4b	154	38	conditional	conditional	JJ
cord-048487-kamvao4b	154	39	on	on	IN
cord-048487-kamvao4b	154	40	the	the	DT
cord-048487-kamvao4b	154	41	rate	rate	NN
cord-048487-kamvao4b	154	42	of	of	IN
cord-048487-kamvao4b	154	43	substitution	substitution	NN
cord-048487-kamvao4b	154	44	.	.	.
cord-048487-kamvao4b	155	1	We	-PRON-	PRP
cord-048487-kamvao4b	155	2	find	find	VBP
cord-048487-kamvao4b	155	3	that	that	IN
cord-048487-kamvao4b	155	4	for	for	IN
cord-048487-kamvao4b	155	5	the	the	DT
cord-048487-kamvao4b	155	6	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	155	7	gene	gene	NN
cord-048487-kamvao4b	155	8	,	,	,
cord-048487-kamvao4b	155	9	a	a	DT
cord-048487-kamvao4b	155	10	proportion	proportion	NN
cord-048487-kamvao4b	155	11	of	of	IN
cord-048487-kamvao4b	155	12	sequence	sequence	NN
cord-048487-kamvao4b	155	13	alignments	alignment	NNS
cord-048487-kamvao4b	155	14	support	support	VBP
cord-048487-kamvao4b	155	15	the	the	DT
cord-048487-kamvao4b	155	16	split	split	NN
cord-048487-kamvao4b	155	17	of	of	IN
cord-048487-kamvao4b	155	18	subtype	subtype	NN
cord-048487-kamvao4b	155	19	B	b	NN
cord-048487-kamvao4b	155	20	from	from	IN
cord-048487-kamvao4b	155	21	subtype	subtype	NN
cord-048487-kamvao4b	155	22	C	c	NN
cord-048487-kamvao4b	155	23	after	after	IN
cord-048487-kamvao4b	155	24	the	the	DT
cord-048487-kamvao4b	155	25	split	split	NN
cord-048487-kamvao4b	155	26	between	between	IN
cord-048487-kamvao4b	155	27	subtypes	subtype	NNS
cord-048487-kamvao4b	155	28	A	A	NNP
cord-048487-kamvao4b	155	29	-	-	:
cord-048487-kamvao4b	155	30	H3N2	H3N2	NNP
cord-048487-kamvao4b	155	31	and	and	CC
cord-048487-kamvao4b	155	32	B	B	NNP
cord-048487-kamvao4b	155	33	,	,	,
cord-048487-kamvao4b	155	34	in	in	IN
cord-048487-kamvao4b	155	35	opposition	opposition	NN
cord-048487-kamvao4b	155	36	to	to	IN
cord-048487-kamvao4b	155	37	the	the	DT
cord-048487-kamvao4b	155	38	topology	topology	NN
cord-048487-kamvao4b	155	39	enforced	enforce	VBN
cord-048487-kamvao4b	155	40	in	in	IN
cord-048487-kamvao4b	155	41	our	-PRON-	PRP$
cord-048487-kamvao4b	155	42	analysis	analysis	NN
cord-048487-kamvao4b	155	43	.	.	.
cord-048487-kamvao4b	156	1	Hence	hence	RB
cord-048487-kamvao4b	156	2	,	,	,
cord-048487-kamvao4b	156	3	to	to	IN
cord-048487-kamvao4b	156	4	some	some	DT
cord-048487-kamvao4b	156	5	unknown	unknown	JJ
cord-048487-kamvao4b	156	6	degree	degree	NN
cord-048487-kamvao4b	156	7	,	,	,
cord-048487-kamvao4b	156	8	our	-PRON-	PRP$
cord-048487-kamvao4b	156	9	analysis	analysis	NN
cord-048487-kamvao4b	156	10	is	be	VBZ
cord-048487-kamvao4b	156	11	necessarily	necessarily	RB
cord-048487-kamvao4b	156	12	biased	bias	VBN
cord-048487-kamvao4b	156	13	by	by	IN
cord-048487-kamvao4b	156	14	the	the	DT
cord-048487-kamvao4b	156	15	choice	choice	NN
cord-048487-kamvao4b	156	16	of	of	IN
cord-048487-kamvao4b	156	17	alignment	alignment	NN
cord-048487-kamvao4b	156	18	.	.	.
cord-048487-kamvao4b	157	1	This	this	DT
cord-048487-kamvao4b	157	2	suggests	suggest	VBZ
cord-048487-kamvao4b	157	3	that	that	IN
cord-048487-kamvao4b	157	4	improved	improve	VBN
cord-048487-kamvao4b	157	5	dating	dating	NN
cord-048487-kamvao4b	157	6	can	can	MD
cord-048487-kamvao4b	157	7	be	be	VB
cord-048487-kamvao4b	157	8	found	find	VBN
cord-048487-kamvao4b	157	9	by	by	IN
cord-048487-kamvao4b	157	10	integrating	integrate	VBG
cord-048487-kamvao4b	157	11	estimation	estimation	NN
cord-048487-kamvao4b	157	12	procedures	procedure	NNS
cord-048487-kamvao4b	157	13	over	over	IN
cord-048487-kamvao4b	157	14	an	an	DT
cord-048487-kamvao4b	157	15	ensemble	ensemble	NN
cord-048487-kamvao4b	157	16	of	of	IN
cord-048487-kamvao4b	157	17	alignments	alignment	NNS
cord-048487-kamvao4b	157	18	[	[	-LRB-
cord-048487-kamvao4b	157	19	19	19	CD
cord-048487-kamvao4b	157	20	]	]	-RRB-
cord-048487-kamvao4b	157	21	.	.	.
cord-048487-kamvao4b	158	1	The	the	DT
cord-048487-kamvao4b	158	2	pairwise	pairwise	JJ
cord-048487-kamvao4b	158	3	estimate	estimate	NN
cord-048487-kamvao4b	158	4	method	method	NN
cord-048487-kamvao4b	158	5	presented	present	VBN
cord-048487-kamvao4b	158	6	above	above	RB
cord-048487-kamvao4b	158	7	is	be	VBZ
cord-048487-kamvao4b	158	8	accurate	accurate	JJ
cord-048487-kamvao4b	158	9	in	in	IN
cord-048487-kamvao4b	158	10	the	the	DT
cord-048487-kamvao4b	158	11	scale	scale	NN
cord-048487-kamvao4b	158	12	where	where	WRB
cord-048487-kamvao4b	158	13	is	be	VBZ
cord-048487-kamvao4b	158	14	the	the	DT
cord-048487-kamvao4b	158	15	total	total	JJ
cord-048487-kamvao4b	158	16	time	time	NN
cord-048487-kamvao4b	158	17	over	over	IN
cord-048487-kamvao4b	158	18	the	the	DT
cord-048487-kamvao4b	158	19	phylogeny	phylogeny	NN
cord-048487-kamvao4b	158	20	and	and	CC
cord-048487-kamvao4b	158	21	p	p	NN
cord-048487-kamvao4b	158	22	is	be	VBZ
cord-048487-kamvao4b	158	23	mean	mean	JJ
cord-048487-kamvao4b	158	24	rate	rate	NN
cord-048487-kamvao4b	158	25	over	over	IN
cord-048487-kamvao4b	158	26	the	the	DT
cord-048487-kamvao4b	158	27	phylogeny	phylogeny	NN
cord-048487-kamvao4b	158	28	[	[	-LRB-
cord-048487-kamvao4b	158	29	26	26	CD
cord-048487-kamvao4b	158	30	]	]	-RRB-
cord-048487-kamvao4b	158	31	.	.	.
cord-048487-kamvao4b	159	1	This	this	DT
cord-048487-kamvao4b	159	2	relation	relation	NN
cord-048487-kamvao4b	159	3	dictates	dictate	VBZ
cord-048487-kamvao4b	159	4	that	that	IN
cord-048487-kamvao4b	159	5	as	as	IN
cord-048487-kamvao4b	159	6	divergence	divergence	NN
cord-048487-kamvao4b	159	7	events	event	NNS
cord-048487-kamvao4b	159	8	become	become	VBP
cord-048487-kamvao4b	159	9	more	more	RBR
cord-048487-kamvao4b	159	10	remote	remote	JJ
cord-048487-kamvao4b	159	11	the	the	DT
cord-048487-kamvao4b	159	12	ability	ability	NN
cord-048487-kamvao4b	159	13	of	of	IN
cord-048487-kamvao4b	159	14	the	the	DT
cord-048487-kamvao4b	159	15	triplet	triplet	NN
cord-048487-kamvao4b	159	16	method	method	NN
cord-048487-kamvao4b	159	17	to	to	TO
cord-048487-kamvao4b	159	18	resolve	resolve	VB
cord-048487-kamvao4b	159	19	the	the	DT
cord-048487-kamvao4b	159	20	time	time	NN
cord-048487-kamvao4b	159	21	of	of	IN
cord-048487-kamvao4b	159	22	divergence	divergence	NN
cord-048487-kamvao4b	159	23	diminishes	diminish	VBZ
cord-048487-kamvao4b	159	24	.	.	.
cord-048487-kamvao4b	160	1	While	while	IN
cord-048487-kamvao4b	160	2	this	this	DT
cord-048487-kamvao4b	160	3	limit	limit	NN
cord-048487-kamvao4b	160	4	prohibits	prohibit	VBZ
cord-048487-kamvao4b	160	5	the	the	DT
cord-048487-kamvao4b	160	6	calculation	calculation	NN
cord-048487-kamvao4b	160	7	of	of	IN
cord-048487-kamvao4b	160	8	remote	remote	JJ
cord-048487-kamvao4b	160	9	divergence	divergence	NN
cord-048487-kamvao4b	160	10	events	event	NNS
cord-048487-kamvao4b	160	11	,	,	,
cord-048487-kamvao4b	160	12	the	the	DT
cord-048487-kamvao4b	160	13	example	example	NN
cord-048487-kamvao4b	160	14	presented	present	VBN
cord-048487-kamvao4b	160	15	above	above	IN
cord-048487-kamvao4b	160	16	lies	lie	NNS
cord-048487-kamvao4b	160	17	within	within	IN
cord-048487-kamvao4b	160	18	the	the	DT
cord-048487-kamvao4b	160	19	appropriate	appropriate	JJ
cord-048487-kamvao4b	160	20	scale	scale	NN
cord-048487-kamvao4b	160	21	.	.	.
cord-048487-kamvao4b	161	1	In	in	IN
cord-048487-kamvao4b	161	2	place	place	NN
cord-048487-kamvao4b	161	3	of	of	IN
cord-048487-kamvao4b	161	4	a	a	DT
cord-048487-kamvao4b	161	5	specific	specific	JJ
cord-048487-kamvao4b	161	6	MCA	MCA	NNP
cord-048487-kamvao4b	161	7	,	,	,
cord-048487-kamvao4b	161	8	the	the	DT
cord-048487-kamvao4b	161	9	estimates	estimate	NNS
cord-048487-kamvao4b	161	10	presented	present	VBN
cord-048487-kamvao4b	161	11	here	here	RB
cord-048487-kamvao4b	161	12	directly	directly	RB
cord-048487-kamvao4b	161	13	calculate	calculate	VB
cord-048487-kamvao4b	161	14	the	the	DT
cord-048487-kamvao4b	161	15	rate	rate	NN
cord-048487-kamvao4b	161	16	of	of	IN
cord-048487-kamvao4b	161	17	substitutions	substitution	NNS
cord-048487-kamvao4b	161	18	between	between	IN
cord-048487-kamvao4b	161	19	taxa	taxon	NNS
cord-048487-kamvao4b	161	20	from	from	IN
cord-048487-kamvao4b	161	21	different	different	JJ
cord-048487-kamvao4b	161	22	viral	viral	JJ
cord-048487-kamvao4b	161	23	subtypes	subtype	NNS
cord-048487-kamvao4b	161	24	.	.	.
cord-048487-kamvao4b	162	1	As	as	IN
cord-048487-kamvao4b	162	2	such	such	JJ
cord-048487-kamvao4b	162	3	estimates	estimate	NNS
cord-048487-kamvao4b	162	4	span	span	VBP
cord-048487-kamvao4b	162	5	paths	path	NNS
cord-048487-kamvao4b	162	6	between	between	IN
cord-048487-kamvao4b	162	7	subtypes	subtype	NNS
cord-048487-kamvao4b	162	8	,	,	,
cord-048487-kamvao4b	162	9	they	-PRON-	PRP
cord-048487-kamvao4b	162	10	simultaneously	simultaneously	RB
cord-048487-kamvao4b	162	11	capture	capture	VBP
cord-048487-kamvao4b	162	12	the	the	DT
cord-048487-kamvao4b	162	13	rate	rate	NN
cord-048487-kamvao4b	162	14	evolution	evolution	NN
cord-048487-kamvao4b	162	15	along	along	IN
cord-048487-kamvao4b	162	16	branches	branch	NNS
cord-048487-kamvao4b	162	17	both	both	CC
cord-048487-kamvao4b	162	18	within	within	IN
cord-048487-kamvao4b	162	19	and	and	CC
cord-048487-kamvao4b	162	20	between	between	IN
cord-048487-kamvao4b	162	21	subtypes	subtype	NNS
cord-048487-kamvao4b	162	22	.	.	.
cord-048487-kamvao4b	163	1	From	from	IN
cord-048487-kamvao4b	163	2	these	these	DT
cord-048487-kamvao4b	163	3	estimates	estimate	NNS
cord-048487-kamvao4b	163	4	,	,	,
cord-048487-kamvao4b	163	5	we	-PRON-	PRP
cord-048487-kamvao4b	163	6	are	be	VBP
cord-048487-kamvao4b	163	7	able	able	JJ
cord-048487-kamvao4b	163	8	to	to	TO
cord-048487-kamvao4b	163	9	directly	directly	RB
cord-048487-kamvao4b	163	10	infer	infer	VB
cord-048487-kamvao4b	163	11	the	the	DT
cord-048487-kamvao4b	163	12	time	time	NN
cord-048487-kamvao4b	163	13	of	of	IN
cord-048487-kamvao4b	163	14	divergence	divergence	NN
cord-048487-kamvao4b	163	15	between	between	IN
cord-048487-kamvao4b	163	16	subtypes	subtype	NNS
cord-048487-kamvao4b	163	17	.	.	.
cord-048487-kamvao4b	164	1	As	as	IN
cord-048487-kamvao4b	164	2	a	a	DT
cord-048487-kamvao4b	164	3	trade	trade	NN
cord-048487-kamvao4b	164	4	-	-	HYPH
cord-048487-kamvao4b	164	5	off	off	NN
cord-048487-kamvao4b	164	6	for	for	IN
cord-048487-kamvao4b	164	7	limited	limited	JJ
cord-048487-kamvao4b	164	8	MCAs	mca	NNS
cord-048487-kamvao4b	164	9	,	,	,
cord-048487-kamvao4b	164	10	the	the	DT
cord-048487-kamvao4b	164	11	method	method	NN
cord-048487-kamvao4b	164	12	requires	require	VBZ
cord-048487-kamvao4b	164	13	an	an	DT
cord-048487-kamvao4b	164	14	outgroup	outgroup	NN
cord-048487-kamvao4b	164	15	subtype	subtype	NN
cord-048487-kamvao4b	164	16	to	to	TO
cord-048487-kamvao4b	164	17	function	function	VB
cord-048487-kamvao4b	164	18	as	as	IN
cord-048487-kamvao4b	164	19	an	an	DT
cord-048487-kamvao4b	164	20	origin	origin	NN
cord-048487-kamvao4b	164	21	relative	relative	JJ
cord-048487-kamvao4b	164	22	to	to	IN
cord-048487-kamvao4b	164	23	the	the	DT
cord-048487-kamvao4b	164	24	subtypes	subtype	NNS
cord-048487-kamvao4b	164	25	under	under	IN
cord-048487-kamvao4b	164	26	consideration	consideration	NN
cord-048487-kamvao4b	164	27	.	.	.
cord-048487-kamvao4b	165	1	We	-PRON-	PRP
cord-048487-kamvao4b	165	2	feel	feel	VBP
cord-048487-kamvao4b	165	3	that	that	IN
cord-048487-kamvao4b	165	4	the	the	DT
cord-048487-kamvao4b	165	5	triplet	triplet	NN
cord-048487-kamvao4b	165	6	method	method	NN
cord-048487-kamvao4b	165	7	provides	provide	VBZ
cord-048487-kamvao4b	165	8	a	a	DT
cord-048487-kamvao4b	165	9	simple	simple	JJ
cord-048487-kamvao4b	165	10	and	and	CC
cord-048487-kamvao4b	165	11	widely	widely	RB
cord-048487-kamvao4b	165	12	applicable	applicable	JJ
cord-048487-kamvao4b	165	13	way	way	NN
cord-048487-kamvao4b	165	14	to	to	TO
cord-048487-kamvao4b	165	15	calculate	calculate	VB
cord-048487-kamvao4b	165	16	the	the	DT
cord-048487-kamvao4b	165	17	dates	date	NNS
cord-048487-kamvao4b	165	18	of	of	IN
cord-048487-kamvao4b	165	19	divergence	divergence	NN
cord-048487-kamvao4b	165	20	of	of	IN
cord-048487-kamvao4b	165	21	rapidly	rapidly	RB
cord-048487-kamvao4b	165	22	evolving	evolve	VBG
cord-048487-kamvao4b	165	23	organisms	organism	NNS
cord-048487-kamvao4b	165	24	without	without	IN
cord-048487-kamvao4b	165	25	the	the	DT
cord-048487-kamvao4b	165	26	pitfalls	pitfall	NNS
cord-048487-kamvao4b	165	27	of	of	IN
cord-048487-kamvao4b	165	28	the	the	DT
cord-048487-kamvao4b	165	29	MCA	MCA	NNP
cord-048487-kamvao4b	165	30	.	.	.
cord-048487-kamvao4b	166	1	We	-PRON-	PRP
cord-048487-kamvao4b	166	2	present	present	VBP
cord-048487-kamvao4b	166	3	a	a	DT
cord-048487-kamvao4b	166	4	simple	simple	JJ
cord-048487-kamvao4b	166	5	method	method	NN
cord-048487-kamvao4b	166	6	for	for	IN
cord-048487-kamvao4b	166	7	calculating	calculate	VBG
cord-048487-kamvao4b	166	8	the	the	DT
cord-048487-kamvao4b	166	9	time	time	NN
cord-048487-kamvao4b	166	10	of	of	IN
cord-048487-kamvao4b	166	11	viral	viral	JJ
cord-048487-kamvao4b	166	12	subtype	subtype	NN
cord-048487-kamvao4b	166	13	divergence	divergence	NN
cord-048487-kamvao4b	166	14	that	that	WDT
cord-048487-kamvao4b	166	15	does	do	VBZ
cord-048487-kamvao4b	166	16	not	not	RB
cord-048487-kamvao4b	166	17	assume	assume	VB
cord-048487-kamvao4b	166	18	a	a	DT
cord-048487-kamvao4b	166	19	molecular	molecular	JJ
cord-048487-kamvao4b	166	20	clock	clock	NN
cord-048487-kamvao4b	166	21	over	over	IN
cord-048487-kamvao4b	166	22	the	the	DT
cord-048487-kamvao4b	166	23	entire	entire	JJ
cord-048487-kamvao4b	166	24	phylogeny	phylogeny	NN
cord-048487-kamvao4b	166	25	.	.	.
cord-048487-kamvao4b	167	1	Additionally	additionally	RB
cord-048487-kamvao4b	167	2	,	,	,
cord-048487-kamvao4b	167	3	the	the	DT
cord-048487-kamvao4b	167	4	estimator	estimator	NN
cord-048487-kamvao4b	167	5	of	of	IN
cord-048487-kamvao4b	167	6	this	this	DT
cord-048487-kamvao4b	167	7	method	method	NN
cord-048487-kamvao4b	167	8	,	,	,
cord-048487-kamvao4b	167	9	a	a	DT
cord-048487-kamvao4b	167	10	weighted	weighted	JJ
cord-048487-kamvao4b	167	11	sum	sum	NN
cord-048487-kamvao4b	167	12	of	of	IN
cord-048487-kamvao4b	167	13	pairwise	pairwise	JJ
cord-048487-kamvao4b	167	14	estimates	estimate	NNS
cord-048487-kamvao4b	167	15	,	,	,
cord-048487-kamvao4b	167	16	furnishes	furnish	VBZ
cord-048487-kamvao4b	167	17	a	a	DT
cord-048487-kamvao4b	167	18	defined	define	VBN
cord-048487-kamvao4b	167	19	variance	variance	NN
cord-048487-kamvao4b	167	20	for	for	IN
cord-048487-kamvao4b	167	21	the	the	DT
cord-048487-kamvao4b	167	22	time	time	NN
cord-048487-kamvao4b	167	23	of	of	IN
cord-048487-kamvao4b	167	24	the	the	DT
cord-048487-kamvao4b	167	25	most	most	RBS
cord-048487-kamvao4b	167	26	common	common	JJ
cord-048487-kamvao4b	167	27	ancestor	ancestor	NN
cord-048487-kamvao4b	167	28	between	between	IN
cord-048487-kamvao4b	167	29	subtypes	subtype	NNS
cord-048487-kamvao4b	167	30	.	.	.
cord-048487-kamvao4b	168	1	As	as	IN
cord-048487-kamvao4b	168	2	a	a	DT
cord-048487-kamvao4b	168	3	tradeoff	tradeoff	NN
cord-048487-kamvao4b	168	4	for	for	IN
cord-048487-kamvao4b	168	5	this	this	DT
cord-048487-kamvao4b	168	6	increased	increase	VBN
cord-048487-kamvao4b	168	7	precision	precision	NN
cord-048487-kamvao4b	168	8	,	,	,
cord-048487-kamvao4b	168	9	the	the	DT
cord-048487-kamvao4b	168	10	structure	structure	NN
cord-048487-kamvao4b	168	11	of	of	IN
cord-048487-kamvao4b	168	12	the	the	DT
cord-048487-kamvao4b	168	13	triplet	triplet	NN
cord-048487-kamvao4b	168	14	statistic	statistic	NN
cord-048487-kamvao4b	168	15	requires	require	VBZ
cord-048487-kamvao4b	168	16	an	an	DT
cord-048487-kamvao4b	168	17	outgroup	outgroup	NN
cord-048487-kamvao4b	168	18	set	set	NN
cord-048487-kamvao4b	168	19	of	of	IN
cord-048487-kamvao4b	168	20	sequences	sequence	NNS
cord-048487-kamvao4b	168	21	,	,	,
cord-048487-kamvao4b	168	22	usually	usually	RB
cord-048487-kamvao4b	168	23	a	a	DT
cord-048487-kamvao4b	168	24	closely	closely	RB
cord-048487-kamvao4b	168	25	related	relate	VBN
cord-048487-kamvao4b	168	26	subtype	subtype	NN
cord-048487-kamvao4b	168	27	.	.	.
cord-048487-kamvao4b	169	1	We	-PRON-	PRP
cord-048487-kamvao4b	169	2	apply	apply	VBP
cord-048487-kamvao4b	169	3	this	this	DT
cord-048487-kamvao4b	169	4	estimator	estimator	NN
cord-048487-kamvao4b	169	5	to	to	IN
cord-048487-kamvao4b	169	6	the	the	DT
cord-048487-kamvao4b	169	7	case	case	NN
cord-048487-kamvao4b	169	8	of	of	IN
cord-048487-kamvao4b	169	9	influenza	influenza	NN
cord-048487-kamvao4b	169	10	subtype	subtype	NN
cord-048487-kamvao4b	169	11	divergence	divergence	NN
cord-048487-kamvao4b	169	12	,	,	,
cord-048487-kamvao4b	169	13	considering	consider	VBG
cord-048487-kamvao4b	169	14	three	three	CD
cord-048487-kamvao4b	169	15	genes	gene	NNS
cord-048487-kamvao4b	169	16	.	.	.
cord-048487-kamvao4b	170	1	We	-PRON-	PRP
cord-048487-kamvao4b	170	2	show	show	VBP
cord-048487-kamvao4b	170	3	that	that	IN
cord-048487-kamvao4b	170	4	the	the	DT
cord-048487-kamvao4b	170	5	estimated	estimate	VBN
cord-048487-kamvao4b	170	6	divergence	divergence	NN
cord-048487-kamvao4b	170	7	time	time	NN
cord-048487-kamvao4b	170	8	of	of	IN
cord-048487-kamvao4b	170	9	subtypes	subtype	NNS
cord-048487-kamvao4b	171	1	A	a	LS
cord-048487-kamvao4b	171	2	-	-	:
cord-048487-kamvao4b	171	3	H3N2	H3N2	NNP
cord-048487-kamvao4b	171	4	and	and	CC
cord-048487-kamvao4b	171	5	B	B	NNP
cord-048487-kamvao4b	171	6	is	be	VBZ
cord-048487-kamvao4b	171	7	more	more	JJR
cord-048487-kamvao4b	171	8	than	than	IN
cord-048487-kamvao4b	171	9	a	a	DT
cord-048487-kamvao4b	171	10	century	century	NN
cord-048487-kamvao4b	171	11	later	later	RB
cord-048487-kamvao4b	171	12	than	than	IN
cord-048487-kamvao4b	171	13	those	those	DT
cord-048487-kamvao4b	171	14	calculated	calculate	VBN
cord-048487-kamvao4b	171	15	with	with	IN
cord-048487-kamvao4b	171	16	a	a	DT
cord-048487-kamvao4b	171	17	molecular	molecular	JJ
cord-048487-kamvao4b	171	18	clock	clock	NN
cord-048487-kamvao4b	171	19	.	.	.
cord-048487-kamvao4b	172	1	Since	since	IN
cord-048487-kamvao4b	172	2	we	-PRON-	PRP
cord-048487-kamvao4b	172	3	assume	assume	VBP
cord-048487-kamvao4b	172	4	that	that	IN
cord-048487-kamvao4b	172	5	the	the	DT
cord-048487-kamvao4b	172	6	ν	ν	NNP
cord-048487-kamvao4b	172	7	and	and	CC
cord-048487-kamvao4b	172	8	ε	ε	NNP
cord-048487-kamvao4b	172	9	structures	structure	NNS
cord-048487-kamvao4b	172	10	are	be	VBP
cord-048487-kamvao4b	172	11	independent	independent	JJ
cord-048487-kamvao4b	172	12	,	,	,
cord-048487-kamvao4b	172	13	the	the	DT
cord-048487-kamvao4b	172	14	right	right	JJ
cord-048487-kamvao4b	172	15	side	side	NN
cord-048487-kamvao4b	172	16	of	of	IN
cord-048487-kamvao4b	172	17	the	the	DT
cord-048487-kamvao4b	172	18	equation	equation	NN
cord-048487-kamvao4b	172	19	can	can	MD
cord-048487-kamvao4b	172	20	be	be	VB
cord-048487-kamvao4b	172	21	further	further	RB
cord-048487-kamvao4b	172	22	reduced	reduce	VBN
cord-048487-kamvao4b	172	23	,	,	,
cord-048487-kamvao4b	172	24	yielding	yield	VBG
cord-048487-kamvao4b	172	25	Let	let	NN
cord-048487-kamvao4b	173	1	Δt	Δt	NNS
cord-048487-kamvao4b	173	2	=	=	NFP
cord-048487-kamvao4b	174	1	t	t	NNP
cord-048487-kamvao4b	174	2	i	i	NNP
cord-048487-kamvao4b	174	3	-t	-t	:
cord-048487-kamvao4b	174	4	j	j	NNP
cord-048487-kamvao4b	174	5	.	.	.
cord-048487-kamvao4b	175	1	The	the	DT
cord-048487-kamvao4b	175	2	final	final	JJ
cord-048487-kamvao4b	175	3	expectation	expectation	NN
cord-048487-kamvao4b	175	4	on	on	IN
cord-048487-kamvao4b	175	5	the	the	DT
cord-048487-kamvao4b	175	6	right	right	JJ
cord-048487-kamvao4b	175	7	hand	hand	NN
cord-048487-kamvao4b	175	8	side	side	NN
cord-048487-kamvao4b	175	9	resolves	resolve	VBZ
cord-048487-kamvao4b	175	10	by	by	IN
cord-048487-kamvao4b	175	11	direct	direct	JJ
cord-048487-kamvao4b	175	12	integration	integration	NN
cord-048487-kamvao4b	175	13	,	,	,
cord-048487-kamvao4b	175	14	We	-PRON-	PRP
cord-048487-kamvao4b	175	15	note	note	VBP
cord-048487-kamvao4b	175	16	that	that	IN
cord-048487-kamvao4b	175	17	as	as	IN
cord-048487-kamvao4b	175	18	the	the	DT
cord-048487-kamvao4b	175	19	sampling	sampling	NN
cord-048487-kamvao4b	175	20	time	time	NN
cord-048487-kamvao4b	175	21	is	be	VBZ
cord-048487-kamvao4b	175	22	independent	independent	JJ
cord-048487-kamvao4b	175	23	of	of	IN
cord-048487-kamvao4b	175	24	the	the	DT
cord-048487-kamvao4b	175	25	rate	rate	NN
cord-048487-kamvao4b	175	26	of	of	IN
cord-048487-kamvao4b	175	27	nucleotide	nucleotide	JJ
cord-048487-kamvao4b	175	28	substitution	substitution	NN
cord-048487-kamvao4b	175	29	,	,	,
cord-048487-kamvao4b	175	30	the	the	DT
cord-048487-kamvao4b	175	31	error	error	NN
cord-048487-kamvao4b	175	32	increases	increase	VBZ
cord-048487-kamvao4b	175	33	in	in	IN
cord-048487-kamvao4b	175	34	proportion	proportion	NN
cord-048487-kamvao4b	175	35	to	to	IN
cord-048487-kamvao4b	175	36	the	the	DT
cord-048487-kamvao4b	175	37	magnitude	magnitude	NN
cord-048487-kamvao4b	175	38	of	of	IN
cord-048487-kamvao4b	175	39	the	the	DT
cord-048487-kamvao4b	175	40	initial	initial	JJ
cord-048487-kamvao4b	175	41	statistic	statistic	NN
cord-048487-kamvao4b	175	42	.	.	.
cord-048487-kamvao4b	176	1	We	-PRON-	PRP
cord-048487-kamvao4b	176	2	can	can	MD
cord-048487-kamvao4b	176	3	then	then	RB
cord-048487-kamvao4b	176	4	create	create	VB
cord-048487-kamvao4b	176	5	a	a	DT
cord-048487-kamvao4b	176	6	new	new	JJ
cord-048487-kamvao4b	176	7	,	,	,
cord-048487-kamvao4b	176	8	unbiased	unbiased	JJ
cord-048487-kamvao4b	176	9	statistic	statistic	NN
cord-048487-kamvao4b	176	10	by	by	IN
cord-048487-kamvao4b	176	11	counterbalancing	counterbalance	VBG
cord-048487-kamvao4b	176	12	the	the	DT
cord-048487-kamvao4b	176	13	original	original	JJ
cord-048487-kamvao4b	176	14	statistic	statistic	NN
cord-048487-kamvao4b	176	15	with	with	IN
cord-048487-kamvao4b	176	16	this	this	DT
cord-048487-kamvao4b	176	17	factor	factor	NN
cord-048487-kamvao4b	176	18	,	,	,
cord-048487-kamvao4b	176	19	making	make	VBG
cord-048487-kamvao4b	176	20	a	a	DT
cord-048487-kamvao4b	176	21	new	new	JJ
cord-048487-kamvao4b	176	22	statistic	statistic	NN
cord-048487-kamvao4b	176	23	Influenza	Influenza	NNP
cord-048487-kamvao4b	176	24	virus	virus	NN
cord-048487-kamvao4b	176	25	genetics	genetics	NN
cord-048487-kamvao4b	176	26	Epidemiology	epidemiology	NN
cord-048487-kamvao4b	176	27	of	of	IN
cord-048487-kamvao4b	176	28	influenza	influenza	NN
cord-048487-kamvao4b	176	29	C	C	NNP
cord-048487-kamvao4b	176	30	virus	virus	NN
cord-048487-kamvao4b	176	31	in	in	IN
cord-048487-kamvao4b	176	32	man	man	NN
cord-048487-kamvao4b	176	33	:	:	:
cord-048487-kamvao4b	176	34	multiple	multiple	JJ
cord-048487-kamvao4b	176	35	evolutionary	evolutionary	JJ
cord-048487-kamvao4b	176	36	lineages	lineage	NNS
cord-048487-kamvao4b	176	37	and	and	CC
cord-048487-kamvao4b	176	38	low	low	JJ
cord-048487-kamvao4b	176	39	rate	rate	NN
cord-048487-kamvao4b	176	40	of	of	IN
cord-048487-kamvao4b	176	41	change	change	NN
cord-048487-kamvao4b	176	42	Avian	avian	JJ
cord-048487-kamvao4b	176	43	influenza	influenza	NN
cord-048487-kamvao4b	176	44	virus	virus	NN
cord-048487-kamvao4b	176	45	exhibits	exhibit	VBZ
cord-048487-kamvao4b	176	46	rapid	rapid	JJ
cord-048487-kamvao4b	176	47	evolutionary	evolutionary	JJ
cord-048487-kamvao4b	176	48	dynamics	dynamic	NNS
cord-048487-kamvao4b	177	1	Influenza	influenza	NN
cord-048487-kamvao4b	177	2	pandemic	pandemic	NN
cord-048487-kamvao4b	177	3	periodicity	periodicity	NN
cord-048487-kamvao4b	177	4	,	,	,
cord-048487-kamvao4b	177	5	virus	virus	NN
cord-048487-kamvao4b	177	6	recycling	recycling	NN
cord-048487-kamvao4b	177	7	,	,	,
cord-048487-kamvao4b	177	8	and	and	CC
cord-048487-kamvao4b	177	9	the	the	DT
cord-048487-kamvao4b	177	10	art	art	NN
cord-048487-kamvao4b	177	11	of	of	IN
cord-048487-kamvao4b	177	12	risk	risk	NN
cord-048487-kamvao4b	177	13	assessment	assessment	NN
cord-048487-kamvao4b	177	14	.	.	.
cord-048487-kamvao4b	178	1	Emerging	emerge	VBG
cord-048487-kamvao4b	178	2	Infectious	Infectious	NNP
cord-048487-kamvao4b	178	3	Diseases	Diseases	NNPS
cord-048487-kamvao4b	179	1	Relaxed	relaxed	JJ
cord-048487-kamvao4b	179	2	phylogenetics	phylogenetic	NNS
cord-048487-kamvao4b	179	3	and	and	CC
cord-048487-kamvao4b	179	4	dating	date	VBG
cord-048487-kamvao4b	179	5	with	with	IN
cord-048487-kamvao4b	179	6	confidence	confidence	NN
cord-048487-kamvao4b	179	7	Estimating	estimating	NN
cord-048487-kamvao4b	179	8	mutation	mutation	NN
cord-048487-kamvao4b	179	9	parameters	parameter	NNS
cord-048487-kamvao4b	179	10	,	,	,
cord-048487-kamvao4b	179	11	population	population	NN
cord-048487-kamvao4b	179	12	history	history	NN
cord-048487-kamvao4b	179	13	and	and	CC
cord-048487-kamvao4b	179	14	genealogy	genealogy	NN
cord-048487-kamvao4b	179	15	simultaneously	simultaneously	RB
cord-048487-kamvao4b	179	16	from	from	IN
cord-048487-kamvao4b	179	17	temporally	temporally	RB
cord-048487-kamvao4b	179	18	spaced	space	VBN
cord-048487-kamvao4b	179	19	sequence	sequence	NN
cord-048487-kamvao4b	179	20	data	datum	NNS
cord-048487-kamvao4b	179	21	Measurably	measurably	RB
cord-048487-kamvao4b	179	22	evolving	evolve	VBG
cord-048487-kamvao4b	179	23	populations	population	NNS
cord-048487-kamvao4b	179	24	Ecological	ecological	JJ
cord-048487-kamvao4b	179	25	and	and	CC
cord-048487-kamvao4b	179	26	immunologial	immunologial	JJ
cord-048487-kamvao4b	179	27	determinants	determinant	NNS
cord-048487-kamvao4b	179	28	of	of	IN
cord-048487-kamvao4b	179	29	influenza	influenza	NN
cord-048487-kamvao4b	179	30	evolution	evolution	NN
cord-048487-kamvao4b	179	31	Dating	date	VBG
cord-048487-kamvao4b	179	32	the	the	DT
cord-048487-kamvao4b	179	33	human	human	JJ
cord-048487-kamvao4b	179	34	-	-	HYPH
cord-048487-kamvao4b	179	35	ape	ape	NN
cord-048487-kamvao4b	179	36	splitting	splitting	NN
cord-048487-kamvao4b	179	37	by	by	IN
cord-048487-kamvao4b	179	38	a	a	DT
cord-048487-kamvao4b	179	39	molecular	molecular	JJ
cord-048487-kamvao4b	179	40	clock	clock	NN
cord-048487-kamvao4b	179	41	of	of	IN
cord-048487-kamvao4b	179	42	mitochondrial	mitochondrial	JJ
cord-048487-kamvao4b	179	43	DNA	dna	NN
cord-048487-kamvao4b	180	1	A	a	DT
cord-048487-kamvao4b	180	2	twenty	twenty	CD
cord-048487-kamvao4b	180	3	-	-	HYPH
cord-048487-kamvao4b	180	4	one	one	CD
cord-048487-kamvao4b	180	5	-	-	HYPH
cord-048487-kamvao4b	180	6	year	year	NN
cord-048487-kamvao4b	180	7	experience	experience	NN
cord-048487-kamvao4b	180	8	with	with	IN
cord-048487-kamvao4b	180	9	anitgenic	anitgenic	NNP
cord-048487-kamvao4b	180	10	variation	variation	NN
cord-048487-kamvao4b	180	11	among	among	IN
cord-048487-kamvao4b	180	12	influenza	influenza	NN
cord-048487-kamvao4b	180	13	B	b	NN
cord-048487-kamvao4b	180	14	viruses	virus	NNS
cord-048487-kamvao4b	181	1	Robust	robust	JJ
cord-048487-kamvao4b	181	2	statistics	statistic	NNS
cord-048487-kamvao4b	181	3	:	:	:
cord-048487-kamvao4b	181	4	A	a	DT
cord-048487-kamvao4b	181	5	review	review	NN
cord-048487-kamvao4b	181	6	Statistical	statistical	JJ
cord-048487-kamvao4b	181	7	estimation	estimation	NN
cord-048487-kamvao4b	181	8	of	of	IN
cord-048487-kamvao4b	181	9	parameters	parameter	NNS
cord-048487-kamvao4b	181	10	in	in	IN
cord-048487-kamvao4b	181	11	a	a	DT
cord-048487-kamvao4b	181	12	phylogenetic	phylogenetic	JJ
cord-048487-kamvao4b	181	13	tree	tree	NN
cord-048487-kamvao4b	181	14	using	use	VBG
cord-048487-kamvao4b	181	15	a	a	DT
cord-048487-kamvao4b	181	16	dynamics	dynamic	NNS
cord-048487-kamvao4b	181	17	model	model	NN
cord-048487-kamvao4b	181	18	of	of	IN
cord-048487-kamvao4b	181	19	the	the	DT
cord-048487-kamvao4b	181	20	substitutional	substitutional	JJ
cord-048487-kamvao4b	181	21	process	process	NN
cord-048487-kamvao4b	181	22	Tracing	trace	VBG
cord-048487-kamvao4b	181	23	the	the	DT
cord-048487-kamvao4b	181	24	origin	origin	NN
cord-048487-kamvao4b	181	25	and	and	CC
cord-048487-kamvao4b	181	26	history	history	NN
cord-048487-kamvao4b	181	27	of	of	IN
cord-048487-kamvao4b	181	28	the	the	DT
cord-048487-kamvao4b	181	29	HIV-2	HIV-2	NNP
cord-048487-kamvao4b	181	30	epidemic	epidemic	NN
cord-048487-kamvao4b	181	31	.	.	.
cord-048487-kamvao4b	182	1	Proceeding	proceed	VBG
cord-048487-kamvao4b	182	2	of	of	IN
cord-048487-kamvao4b	182	3	the	the	DT
cord-048487-kamvao4b	182	4	National	National	NNP
cord-048487-kamvao4b	182	5	Academy	Academy	NNP
cord-048487-kamvao4b	182	6	of	of	IN
cord-048487-kamvao4b	182	7	Sciences	Sciences	NNPS
cord-048487-kamvao4b	182	8	Date	Date	NNP
cord-048487-kamvao4b	182	9	of	of	IN
cord-048487-kamvao4b	182	10	origin	origin	NN
cord-048487-kamvao4b	182	11	of	of	IN
cord-048487-kamvao4b	182	12	the	the	DT
cord-048487-kamvao4b	182	13	SARS	SARS	NNP
cord-048487-kamvao4b	182	14	coronavirus	coronavirus	NN
cord-048487-kamvao4b	182	15	strains	strain	NNS
cord-048487-kamvao4b	183	1	The	the	DT
cord-048487-kamvao4b	183	2	value	value	NN
cord-048487-kamvao4b	183	3	of	of	IN
cord-048487-kamvao4b	183	4	a	a	DT
cord-048487-kamvao4b	183	5	database	database	NN
cord-048487-kamvao4b	183	6	in	in	IN
cord-048487-kamvao4b	183	7	surveillance	surveillance	NN
cord-048487-kamvao4b	183	8	and	and	CC
cord-048487-kamvao4b	183	9	vaccine	vaccine	NN
cord-048487-kamvao4b	183	10	selection	selection	NN
cord-048487-kamvao4b	183	11	Transmissibility	transmissibility	NN
cord-048487-kamvao4b	183	12	of	of	IN
cord-048487-kamvao4b	183	13	1918	1918	CD
cord-048487-kamvao4b	183	14	pandemic	pandemic	NN
cord-048487-kamvao4b	183	15	influenza	influenza	NN
cord-048487-kamvao4b	183	16	Estimating	estimate	VBG
cord-048487-kamvao4b	183	17	the	the	DT
cord-048487-kamvao4b	183	18	rate	rate	NN
cord-048487-kamvao4b	183	19	of	of	IN
cord-048487-kamvao4b	183	20	molecular	molecular	JJ
cord-048487-kamvao4b	183	21	evolution	evolution	NN
cord-048487-kamvao4b	183	22	:	:	:
cord-048487-kamvao4b	184	1	Incorporating	incorporate	VBG
cord-048487-kamvao4b	184	2	non	non	JJ
cord-048487-kamvao4b	184	3	-	-	JJ
cord-048487-kamvao4b	184	4	contemporaneous	contemporaneous	JJ
cord-048487-kamvao4b	184	5	sequences	sequence	NNS
cord-048487-kamvao4b	184	6	into	into	IN
cord-048487-kamvao4b	184	7	maximum	maximum	JJ
cord-048487-kamvao4b	184	8	likelihood	likelihood	NN
cord-048487-kamvao4b	184	9	phylogenies	phylogeny	NNS
cord-048487-kamvao4b	184	10	Joint	joint	JJ
cord-048487-kamvao4b	184	11	Bayesian	bayesian	JJ
cord-048487-kamvao4b	184	12	estimation	estimation	NN
cord-048487-kamvao4b	184	13	of	of	IN
cord-048487-kamvao4b	184	14	alignment	alignment	NN
cord-048487-kamvao4b	184	15	and	and	CC
cord-048487-kamvao4b	184	16	phylogeny	phylogeny	NN
cord-048487-kamvao4b	184	17	Tests	test	NNS
cord-048487-kamvao4b	184	18	of	of	IN
cord-048487-kamvao4b	184	19	applicability	applicability	NN
cord-048487-kamvao4b	184	20	of	of	IN
cord-048487-kamvao4b	184	21	several	several	JJ
cord-048487-kamvao4b	184	22	substitution	substitution	NN
cord-048487-kamvao4b	184	23	models	model	NNS
cord-048487-kamvao4b	184	24	for	for	IN
cord-048487-kamvao4b	184	25	DNA	dna	NN
cord-048487-kamvao4b	184	26	sequence	sequence	NN
cord-048487-kamvao4b	184	27	data	data	NN
cord-048487-kamvao4b	184	28	r8s	r8s	CD
cord-048487-kamvao4b	184	29	:	:	:
cord-048487-kamvao4b	185	1	inferring	infer	VBG
cord-048487-kamvao4b	185	2	absolute	absolute	JJ
cord-048487-kamvao4b	185	3	rates	rate	NNS
cord-048487-kamvao4b	185	4	of	of	IN
cord-048487-kamvao4b	185	5	molecular	molecular	JJ
cord-048487-kamvao4b	185	6	evolution	evolution	NN
cord-048487-kamvao4b	185	7	and	and	CC
cord-048487-kamvao4b	185	8	divergence	divergence	NN
cord-048487-kamvao4b	185	9	times	time	NNS
cord-048487-kamvao4b	185	10	in	in	IN
cord-048487-kamvao4b	185	11	the	the	DT
cord-048487-kamvao4b	185	12	absence	absence	NN
cord-048487-kamvao4b	185	13	of	of	IN
cord-048487-kamvao4b	185	14	a	a	DT
cord-048487-kamvao4b	185	15	molecular	molecular	JJ
cord-048487-kamvao4b	185	16	clock	clock	NN
cord-048487-kamvao4b	185	17	A	a	DT
cord-048487-kamvao4b	185	18	viral	viral	JJ
cord-048487-kamvao4b	185	19	sampling	sampling	NN
cord-048487-kamvao4b	185	20	design	design	NN
cord-048487-kamvao4b	185	21	for	for	IN
cord-048487-kamvao4b	185	22	testing	test	VBG
cord-048487-kamvao4b	185	23	the	the	DT
cord-048487-kamvao4b	185	24	molecular	molecular	JJ
cord-048487-kamvao4b	185	25	clock	clock	NN
cord-048487-kamvao4b	185	26	and	and	CC
cord-048487-kamvao4b	185	27	for	for	IN
cord-048487-kamvao4b	185	28	estimating	estimate	VBG
cord-048487-kamvao4b	185	29	evolutionary	evolutionary	JJ
cord-048487-kamvao4b	185	30	rates	rate	NNS
cord-048487-kamvao4b	185	31	and	and	CC
cord-048487-kamvao4b	185	32	divergence	divergence	NN
cord-048487-kamvao4b	185	33	times	time	NNS
cord-048487-kamvao4b	185	34	Origin	Origin	NNP
cord-048487-kamvao4b	185	35	and	and	CC
cord-048487-kamvao4b	185	36	evolution	evolution	NN
cord-048487-kamvao4b	185	37	of	of	IN
cord-048487-kamvao4b	185	38	influenza	influenza	NN
cord-048487-kamvao4b	185	39	hemagglutinin	hemagglutinin	NN
cord-048487-kamvao4b	185	40	genes	gene	NNS
cord-048487-kamvao4b	186	1	The	the	DT
cord-048487-kamvao4b	186	2	Clustal	Clustal	NNP
cord-048487-kamvao4b	186	3	X	X	NNP
cord-048487-kamvao4b	186	4	windows	windows	NNP
cord-048487-kamvao4b	186	5	interface	interface	NN
cord-048487-kamvao4b	186	6	:	:	:
cord-048487-kamvao4b	186	7	flexible	flexible	JJ
cord-048487-kamvao4b	186	8	strategies	strategy	NNS
cord-048487-kamvao4b	186	9	for	for	IN
cord-048487-kamvao4b	186	10	multiple	multiple	JJ
cord-048487-kamvao4b	186	11	sequence	sequence	NN
cord-048487-kamvao4b	186	12	alignment	alignment	NN
cord-048487-kamvao4b	186	13	aided	aid	VBN
cord-048487-kamvao4b	186	14	by	by	IN
cord-048487-kamvao4b	186	15	quality	quality	NN
cord-048487-kamvao4b	186	16	analysis	analysis	NN
cord-048487-kamvao4b	186	17	tools	tool	NNS
cord-048487-kamvao4b	186	18	Inferring	infer	VBG
cord-048487-kamvao4b	186	19	the	the	DT
cord-048487-kamvao4b	186	20	rate	rate	NN
cord-048487-kamvao4b	186	21	and	and	CC
cord-048487-kamvao4b	186	22	timescale	timescale	NN
cord-048487-kamvao4b	186	23	of	of	IN
cord-048487-kamvao4b	186	24	Dengue	Dengue	NNP
cord-048487-kamvao4b	186	25	virus	virus	NN
cord-048487-kamvao4b	186	26	evolution	evolution	NN
cord-048487-kamvao4b	186	27	JDO'B	JDO'B	NNP
cord-048487-kamvao4b	186	28	collected	collect	VBD
cord-048487-kamvao4b	186	29	the	the	DT
cord-048487-kamvao4b	186	30	data	datum	NNS
cord-048487-kamvao4b	186	31	,	,	,
cord-048487-kamvao4b	186	32	designed	design	VBN
cord-048487-kamvao4b	186	33	and	and	CC
cord-048487-kamvao4b	186	34	performed	perform	VBD
cord-048487-kamvao4b	186	35	the	the	DT
cord-048487-kamvao4b	186	36	study	study	NN
cord-048487-kamvao4b	186	37	and	and	CC
cord-048487-kamvao4b	186	38	wrote	write	VBD
cord-048487-kamvao4b	186	39	the	the	DT
cord-048487-kamvao4b	186	40	initial	initial	JJ
cord-048487-kamvao4b	186	41	manuscript	manuscript	NN
cord-048487-kamvao4b	186	42	.	.	.
cord-048487-kamvao4b	187	1	ZSS	ZSS	NNP
cord-048487-kamvao4b	187	2	provided	provide	VBD
cord-048487-kamvao4b	187	3	extensive	extensive	JJ
cord-048487-kamvao4b	187	4	review	review	NN
cord-048487-kamvao4b	187	5	of	of	IN
cord-048487-kamvao4b	187	6	the	the	DT
cord-048487-kamvao4b	187	7	study	study	NN
cord-048487-kamvao4b	187	8	design	design	NN
cord-048487-kamvao4b	187	9	and	and	CC
cord-048487-kamvao4b	187	10	provided	provide	VBN
cord-048487-kamvao4b	187	11	assistance	assistance	NN
cord-048487-kamvao4b	187	12	in	in	IN
cord-048487-kamvao4b	187	13	revising	revise	VBG
cord-048487-kamvao4b	187	14	the	the	DT
cord-048487-kamvao4b	187	15	manuscript	manuscript	NN
cord-048487-kamvao4b	187	16	.	.	.
cord-048487-kamvao4b	188	1	MAS	MAS	NNP
cord-048487-kamvao4b	188	2	contributed	contribute	VBD
cord-048487-kamvao4b	188	3	extensive	extensive	JJ
cord-048487-kamvao4b	188	4	work	work	NN
cord-048487-kamvao4b	188	5	in	in	IN
cord-048487-kamvao4b	188	6	reviewing	review	VBG
cord-048487-kamvao4b	188	7	and	and	CC
cord-048487-kamvao4b	188	8	revising	revise	VBG
cord-048487-kamvao4b	188	9	the	the	DT
cord-048487-kamvao4b	188	10	manuscript	manuscript	NN
cord-048487-kamvao4b	188	11	.	.	.
cord-048487-kamvao4b	189	1	Initially	initially	RB
cord-048487-kamvao4b	189	2	,	,	,
cord-048487-kamvao4b	189	3	one	one	PRP
cord-048487-kamvao4b	189	4	might	may	MD
cord-048487-kamvao4b	189	5	define	define	VB
cord-048487-kamvao4b	189	6	an	an	DT
cord-048487-kamvao4b	189	7	estimator	estimator	NN
cord-048487-kamvao4b	189	8	of	of	IN
cord-048487-kamvao4b	189	9	the	the	DT
cord-048487-kamvao4b	189	10	conditional	conditional	JJ
cord-048487-kamvao4b	189	11	pairwise	pairwise	JJ
cord-048487-kamvao4b	189	12	rate	rate	NN
cord-048487-kamvao4b	189	13	to	to	TO
cord-048487-kamvao4b	189	14	be	be	VB
cord-048487-kamvao4b	189	15	that	that	DT
cord-048487-kamvao4b	189	16	has	have	VBZ
cord-048487-kamvao4b	189	17	been	be	VBN
cord-048487-kamvao4b	189	18	previously	previously	RB
cord-048487-kamvao4b	189	19	used	use	VBN
cord-048487-kamvao4b	189	20	in	in	IN
cord-048487-kamvao4b	189	21	the	the	DT
cord-048487-kamvao4b	189	22	paper	paper	NN
cord-048487-kamvao4b	189	23	outlining	outline	VBG
cord-048487-kamvao4b	189	24	the	the	DT
cord-048487-kamvao4b	189	25	TREBLE	treble	NN
cord-048487-kamvao4b	189	26	algorithm	algorithm	NN
cord-048487-kamvao4b	189	27	[	[	-LRB-
cord-048487-kamvao4b	189	28	26	26	CD
cord-048487-kamvao4b	189	29	]	]	-RRB-
cord-048487-kamvao4b	189	30	,	,	,
cord-048487-kamvao4b	189	31	and	and	CC
cord-048487-kamvao4b	189	32	originates	originate	VBZ
cord-048487-kamvao4b	189	33	in	in	IN
cord-048487-kamvao4b	189	34	[	[	-LRB-
cord-048487-kamvao4b	189	35	13	13	CD
cord-048487-kamvao4b	189	36	]	]	-RRB-
cord-048487-kamvao4b	189	37	.	.	.
cord-048487-kamvao4b	190	1	However	however	RB
cord-048487-kamvao4b	190	2	,	,	,
cord-048487-kamvao4b	190	3	this	this	DT
cord-048487-kamvao4b	190	4	apparently	apparently	RB
cord-048487-kamvao4b	190	5	natural	natural	JJ
cord-048487-kamvao4b	190	6	statistic	statistic	NN
cord-048487-kamvao4b	190	7	is	be	VBZ
cord-048487-kamvao4b	190	8	substantially	substantially	RB
cord-048487-kamvao4b	190	9	biased	biased	JJ
cord-048487-kamvao4b	190	10	when	when	WRB
cord-048487-kamvao4b	190	11	the	the	DT
cord-048487-kamvao4b	190	12	sampling	sampling	NN
cord-048487-kamvao4b	190	13	times	time	NNS
cord-048487-kamvao4b	190	14	of	of	IN
cord-048487-kamvao4b	190	15	sequences	sequence	NNS
cord-048487-kamvao4b	190	16	i	i	PRP
cord-048487-kamvao4b	190	17	and	and	CC
cord-048487-kamvao4b	190	18	j	j	NNP
cord-048487-kamvao4b	190	19	are	be	VBP
cord-048487-kamvao4b	190	20	close	close	JJ
cord-048487-kamvao4b	190	21	.	.	.
cord-048487-kamvao4b	191	1	To	to	TO
cord-048487-kamvao4b	191	2	be	be	VB
cord-048487-kamvao4b	191	3	seen	see	VBN
cord-048487-kamvao4b	191	4	in	in	IN
cord-048487-kamvao4b	191	5	the	the	DT
cord-048487-kamvao4b	191	6	following	follow	VBG
cord-048487-kamvao4b	191	7	derivation	derivation	NN
cord-048487-kamvao4b	191	8	,	,	,
cord-048487-kamvao4b	191	9	this	this	DT
cord-048487-kamvao4b	191	10	bias	bias	NN
cord-048487-kamvao4b	191	11	is	be	VBZ
cord-048487-kamvao4b	191	12	the	the	DT
cord-048487-kamvao4b	191	13	result	result	NN
cord-048487-kamvao4b	191	14	of	of	IN
cord-048487-kamvao4b	191	15	the	the	DT
cord-048487-kamvao4b	191	16	time	time	NN
cord-048487-kamvao4b	191	17	sampling	sampling	NN
cord-048487-kamvao4b	191	18	error	error	NN
cord-048487-kamvao4b	191	19	structure	structure	NN
cord-048487-kamvao4b	191	20	.	.	.
cord-048487-kamvao4b	192	1	As	as	IN
cord-048487-kamvao4b	192	2	the	the	DT
cord-048487-kamvao4b	192	3	true	true	JJ
cord-048487-kamvao4b	192	4	value	value	NN
cord-048487-kamvao4b	192	5	of	of	IN
cord-048487-kamvao4b	192	6	the	the	DT
cord-048487-kamvao4b	192	7	rate	rate	NN
cord-048487-kamvao4b	192	8	of	of	IN
cord-048487-kamvao4b	192	9	substitution	substitution	NN
cord-048487-kamvao4b	192	10	is	be	VBZ
cord-048487-kamvao4b	192	11	given	give	VBN
cord-048487-kamvao4b	192	12	by	by	IN
cord-048487-kamvao4b	192	13	we	-PRON-	PRP
cord-048487-kamvao4b	192	14	then	then	RB
cord-048487-kamvao4b	192	15	have	have	VBP
cord-048487-kamvao4b	192	16	an	an	DT
cord-048487-kamvao4b	192	17	expression	expression	NN
cord-048487-kamvao4b	192	18	for	for	IN
cord-048487-kamvao4b	192	19	the	the	DT
cord-048487-kamvao4b	192	20	error	error	NN
cord-048487-kamvao4b	192	21	:	:	:
cord-048487-kamvao4b	192	22	Taking	take	VBG
cord-048487-kamvao4b	192	23	the	the	DT
cord-048487-kamvao4b	192	24	expectation	expectation	NN
cord-048487-kamvao4b	192	25	yields	yield	VBZ
cord-048487-kamvao4b	192	26	the	the	DT
cord-048487-kamvao4b	192	27	bias	bias	NN
cord-048487-kamvao4b	192	28	:	:	:
cord-048487-kamvao4b	192	29	Publish	publish	VB
cord-048487-kamvao4b	192	30	with	with	IN
cord-048487-kamvao4b	192	31	Bio	Bio	NNP
cord-048487-kamvao4b	192	32	Med	Med	NNP
cord-048487-kamvao4b	192	33	Central	Central	NNP
cord-048487-kamvao4b	192	34	and	and	CC
cord-048487-kamvao4b	192	35	every	every	DT
cord-048487-kamvao4b	192	36	scientist	scientist	NN
cord-048487-kamvao4b	192	37	can	can	MD
cord-048487-kamvao4b	192	38	read	read	VB
cord-048487-kamvao4b	192	39	your	-PRON-	PRP$
cord-048487-kamvao4b	192	40	work	work	NN
cord-048487-kamvao4b	192	41	free	free	JJ
cord-048487-kamvao4b	192	42	of	of	IN
cord-048487-kamvao4b	192	43	charge	charge	NN
cord-048487-kamvao4b	192	44	)	)	-RRB-
cord-048487-kamvao4b	192	45	.	.	.
cord-048487-kamvao4b	192	46	 	 	_SP