id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276260-iccaqz8u	Namsolleck, Pawel	Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?	2020-08-17		.txt	text/plain	2465	151	48	On the other hand, as part of the Protective Arm of RAS, Ang II also stimulates the angiotensin II type 2 receptor (AT 2 R) and this octapeptide can be further cleaved by the carboxypeptidase ACE2 to yield angiotensin-(1-7) (Ang-(1-7)), an agonist of the Mas receptor (MasR). Here we consider therapeutic perspectives of stable and specific AT 2 R and MasR agonists in The balance between the Detrimental and Protective Arm of RAS is in several aspects seriously disturbed in COVID-19, thus causing a potentially lethal disease (Fig. 1) . Abbreviations RAS: Renin angiotensin system; SARS: Severe acute respiratory syndrome; CoV-2: Coronavirus 2; COVID-19: Coronavirus disease 2019; ARDS: Acute respiratory distress syndrome; AT 2 R: Angiotensin II type 2 receptor; MasR: Mas receptor; ARB: Angiotensin II type 1 receptor blocker; ACE: Angiotensin converting enzyme; ACEi: Angiotensin converting enzyme inhibitor; Ang II: Angiotensin II; Ang-(1-7): Angiotensin-(1-7)	./cache/cord-276260-iccaqz8u.txt	./txt/cord-276260-iccaqz8u.txt