id sid tid token lemma pos cord-329844-w969lczb 1 1 key key NN cord-329844-w969lczb 1 2 : : : cord-329844-w969lczb 1 3 cord-329844-w969lczb cord-329844-w969lczb NNS cord-329844-w969lczb 1 4 authors author NNS cord-329844-w969lczb 1 5 : : : cord-329844-w969lczb 1 6 Robson Robson NNP cord-329844-w969lczb 1 7 , , , cord-329844-w969lczb 1 8 B. B. NNP cord-329844-w969lczb 1 9 title title NN cord-329844-w969lczb 1 10 : : : cord-329844-w969lczb 1 11 Bioinformatics Bioinformatics NNP cord-329844-w969lczb 1 12 studies study NNS cord-329844-w969lczb 1 13 on on IN cord-329844-w969lczb 1 14 a a DT cord-329844-w969lczb 1 15 function function NN cord-329844-w969lczb 1 16 of of IN cord-329844-w969lczb 1 17 the the DT cord-329844-w969lczb 1 18 SARS SARS NNP cord-329844-w969lczb 1 19 - - HYPH cord-329844-w969lczb 1 20 CoV-2 CoV-2 NNP cord-329844-w969lczb 1 21 spike spike NN cord-329844-w969lczb 1 22 glycoprotein glycoprotein NN cord-329844-w969lczb 1 23 as as IN cord-329844-w969lczb 1 24 the the DT cord-329844-w969lczb 1 25 binding binding NN cord-329844-w969lczb 1 26 of of IN cord-329844-w969lczb 1 27 host host NN cord-329844-w969lczb 1 28 sialic sialic NN cord-329844-w969lczb 1 29 acid acid NN cord-329844-w969lczb 1 30 glycans glycan NNS cord-329844-w969lczb 1 31 date date NN cord-329844-w969lczb 1 32 : : : cord-329844-w969lczb 1 33 2020 2020 CD cord-329844-w969lczb 1 34 - - HYPH cord-329844-w969lczb 1 35 06 06 CD cord-329844-w969lczb 1 36 - - HYPH cord-329844-w969lczb 1 37 08 08 CD cord-329844-w969lczb 1 38 journal journal NN cord-329844-w969lczb 1 39 : : : cord-329844-w969lczb 2 1 Comput Comput NNP cord-329844-w969lczb 2 2 Biol Biol NNP cord-329844-w969lczb 2 3 Med Med NNP cord-329844-w969lczb 2 4 DOI DOI NNP cord-329844-w969lczb 2 5 : : : cord-329844-w969lczb 2 6 10.1016 10.1016 CD cord-329844-w969lczb 2 7 / / SYM cord-329844-w969lczb 2 8 j.compbiomed.2020.103849 j.compbiomed.2020.103849 NNP cord-329844-w969lczb 2 9 sha sha NNP cord-329844-w969lczb 2 10 : : : cord-329844-w969lczb 2 11 69a4aea58199a904c06040fed91705d5e4ddeea5 69a4aea58199a904c06040fed91705d5e4ddeea5 CD cord-329844-w969lczb 2 12 doc_id doc_id CD cord-329844-w969lczb 2 13 : : : cord-329844-w969lczb 2 14 329844 329844 CD cord-329844-w969lczb 2 15 cord_uid cord_uid NNS cord-329844-w969lczb 2 16 : : : cord-329844-w969lczb 2 17 w969lczb w969lczb NNP cord-329844-w969lczb 2 18 SARS SARS NNP cord-329844-w969lczb 2 19 - - HYPH cord-329844-w969lczb 2 20 CoV CoV NNP cord-329844-w969lczb 2 21 and and CC cord-329844-w969lczb 2 22 SARS SARS NNP cord-329844-w969lczb 2 23 - - HYPH cord-329844-w969lczb 2 24 CoV-2 CoV-2 NNP cord-329844-w969lczb 2 25 do do VBP cord-329844-w969lczb 2 26 not not RB cord-329844-w969lczb 2 27 appear appear VB cord-329844-w969lczb 2 28 to to TO cord-329844-w969lczb 2 29 have have VB cord-329844-w969lczb 2 30 functions function NNS cord-329844-w969lczb 2 31 of of IN cord-329844-w969lczb 2 32 a a DT cord-329844-w969lczb 2 33 hemagglutinin hemagglutinin NN cord-329844-w969lczb 2 34 and and CC cord-329844-w969lczb 2 35 neuraminidase neuraminidase NN cord-329844-w969lczb 2 36 . . . cord-329844-w969lczb 3 1 This this DT cord-329844-w969lczb 3 2 is be VBZ cord-329844-w969lczb 3 3 a a DT cord-329844-w969lczb 3 4 mystery mystery NN cord-329844-w969lczb 3 5 , , , cord-329844-w969lczb 3 6 because because IN cord-329844-w969lczb 3 7 sugar sugar NN cord-329844-w969lczb 3 8 binding binding NN cord-329844-w969lczb 3 9 activities activity NNS cord-329844-w969lczb 3 10 appear appear VBP cord-329844-w969lczb 3 11 essential essential JJ cord-329844-w969lczb 3 12 to to IN cord-329844-w969lczb 3 13 many many JJ cord-329844-w969lczb 3 14 other other JJ cord-329844-w969lczb 3 15 viruses virus NNS cord-329844-w969lczb 3 16 including include VBG cord-329844-w969lczb 3 17 influenza influenza NN cord-329844-w969lczb 3 18 and and CC cord-329844-w969lczb 3 19 even even RB cord-329844-w969lczb 3 20 most most JJS cord-329844-w969lczb 3 21 other other JJ cord-329844-w969lczb 3 22 coronaviruses coronaviruse NNS cord-329844-w969lczb 3 23 in in IN cord-329844-w969lczb 3 24 order order NN cord-329844-w969lczb 3 25 to to TO cord-329844-w969lczb 3 26 bind bind VB cord-329844-w969lczb 3 27 to to IN cord-329844-w969lczb 3 28 and and CC cord-329844-w969lczb 3 29 escape escape VB cord-329844-w969lczb 3 30 from from IN cord-329844-w969lczb 3 31 the the DT cord-329844-w969lczb 3 32 glycans glycan NNS cord-329844-w969lczb 3 33 ( ( -LRB- cord-329844-w969lczb 3 34 sugars sugar NNS cord-329844-w969lczb 3 35 , , , cord-329844-w969lczb 3 36 oligosaccharides oligosaccharide NNS cord-329844-w969lczb 3 37 or or CC cord-329844-w969lczb 3 38 polysaccharides polysaccharide NNS cord-329844-w969lczb 3 39 ) ) -RRB- cord-329844-w969lczb 3 40 characteristic characteristic NN cord-329844-w969lczb 3 41 of of IN cord-329844-w969lczb 3 42 cell cell NN cord-329844-w969lczb 3 43 surfaces surface NNS cord-329844-w969lczb 3 44 and and CC cord-329844-w969lczb 3 45 saliva saliva NN cord-329844-w969lczb 3 46 and and CC cord-329844-w969lczb 3 47 mucin mucin NN cord-329844-w969lczb 3 48 . . . cord-329844-w969lczb 4 1 The the DT cord-329844-w969lczb 4 2 S1 S1 NNP cord-329844-w969lczb 4 3 N N NNP cord-329844-w969lczb 4 4 terminal terminal NN cord-329844-w969lczb 4 5 Domains domain NNS cord-329844-w969lczb 4 6 ( ( -LRB- cord-329844-w969lczb 4 7 S1-NTD S1-NTD NNP cord-329844-w969lczb 4 8 ) ) -RRB- cord-329844-w969lczb 4 9 of of IN cord-329844-w969lczb 4 10 the the DT cord-329844-w969lczb 4 11 spike spike NN cord-329844-w969lczb 4 12 protein protein NN cord-329844-w969lczb 4 13 , , , cord-329844-w969lczb 4 14 largely largely RB cord-329844-w969lczb 4 15 responsible responsible JJ cord-329844-w969lczb 4 16 for for IN cord-329844-w969lczb 4 17 the the DT cord-329844-w969lczb 4 18 bulk bulk NN cord-329844-w969lczb 4 19 of of IN cord-329844-w969lczb 4 20 the the DT cord-329844-w969lczb 4 21 characteristic characteristic JJ cord-329844-w969lczb 4 22 knobs knob NNS cord-329844-w969lczb 4 23 at at IN cord-329844-w969lczb 4 24 the the DT cord-329844-w969lczb 4 25 end end NN cord-329844-w969lczb 4 26 of of IN cord-329844-w969lczb 4 27 the the DT cord-329844-w969lczb 4 28 spikes spike NNS cord-329844-w969lczb 4 29 of of IN cord-329844-w969lczb 4 30 SARS SARS NNP cord-329844-w969lczb 4 31 - - HYPH cord-329844-w969lczb 4 32 CoV CoV NNP cord-329844-w969lczb 4 33 and and CC cord-329844-w969lczb 4 34 SARS SARS NNP cord-329844-w969lczb 4 35 - - HYPH cord-329844-w969lczb 4 36 CoV-2 CoV-2 NNP cord-329844-w969lczb 4 37 , , , cord-329844-w969lczb 4 38 are be VBP cord-329844-w969lczb 4 39 here here RB cord-329844-w969lczb 4 40 predicted predict VBN cord-329844-w969lczb 4 41 to to TO cord-329844-w969lczb 4 42 be be VB cord-329844-w969lczb 4 43 “ " `` cord-329844-w969lczb 4 44 hiding hide VBG cord-329844-w969lczb 4 45 ” " '' cord-329844-w969lczb 4 46 sites site NNS cord-329844-w969lczb 4 47 for for IN cord-329844-w969lczb 4 48 recognizing recognize VBG cord-329844-w969lczb 4 49 and and CC cord-329844-w969lczb 4 50 binding bind VBG cord-329844-w969lczb 4 51 glycans glycan NNS cord-329844-w969lczb 4 52 containing contain VBG cord-329844-w969lczb 4 53 sialic sialic JJ cord-329844-w969lczb 4 54 acid acid NN cord-329844-w969lczb 4 55 . . . cord-329844-w969lczb 5 1 This this DT cord-329844-w969lczb 5 2 may may MD cord-329844-w969lczb 5 3 be be VB cord-329844-w969lczb 5 4 important important JJ cord-329844-w969lczb 5 5 for for IN cord-329844-w969lczb 5 6 infection infection NN cord-329844-w969lczb 5 7 and and CC cord-329844-w969lczb 5 8 the the DT cord-329844-w969lczb 5 9 ability ability NN cord-329844-w969lczb 5 10 of of IN cord-329844-w969lczb 5 11 the the DT cord-329844-w969lczb 5 12 virus virus NN cord-329844-w969lczb 5 13 to to TO cord-329844-w969lczb 5 14 locate locate VB cord-329844-w969lczb 5 15 ACE2 ACE2 NNP cord-329844-w969lczb 5 16 as as IN cord-329844-w969lczb 5 17 its -PRON- PRP$ cord-329844-w969lczb 5 18 known know VBN cord-329844-w969lczb 5 19 main main JJ cord-329844-w969lczb 5 20 host host NN cord-329844-w969lczb 5 21 cell cell NN cord-329844-w969lczb 5 22 surface surface NN cord-329844-w969lczb 5 23 receptor receptor NN cord-329844-w969lczb 5 24 , , , cord-329844-w969lczb 5 25 and and CC cord-329844-w969lczb 5 26 if if IN cord-329844-w969lczb 5 27 so so RB cord-329844-w969lczb 5 28 it -PRON- PRP cord-329844-w969lczb 5 29 becomes become VBZ cord-329844-w969lczb 5 30 a a DT cord-329844-w969lczb 5 31 pharmaceutical pharmaceutical JJ cord-329844-w969lczb 5 32 target target NN cord-329844-w969lczb 5 33 . . . cord-329844-w969lczb 6 1 It -PRON- PRP cord-329844-w969lczb 6 2 might may MD cord-329844-w969lczb 6 3 even even RB cord-329844-w969lczb 6 4 open open VB cord-329844-w969lczb 6 5 up up RP cord-329844-w969lczb 6 6 the the DT cord-329844-w969lczb 6 7 possibility possibility NN cord-329844-w969lczb 6 8 of of IN cord-329844-w969lczb 6 9 an an DT cord-329844-w969lczb 6 10 alternative alternative JJ cord-329844-w969lczb 6 11 receptor receptor NN cord-329844-w969lczb 6 12 to to IN cord-329844-w969lczb 6 13 ACE2 ACE2 NNP cord-329844-w969lczb 6 14 . . . cord-329844-w969lczb 7 1 The the DT cord-329844-w969lczb 7 2 prediction prediction NN cord-329844-w969lczb 7 3 method method NN cord-329844-w969lczb 7 4 developed develop VBN cord-329844-w969lczb 7 5 , , , cord-329844-w969lczb 7 6 which which WDT cord-329844-w969lczb 7 7 uses use VBZ cord-329844-w969lczb 7 8 amino amino NN cord-329844-w969lczb 7 9 acid acid NN cord-329844-w969lczb 7 10 residue residue NN cord-329844-w969lczb 7 11 sequence sequence NN cord-329844-w969lczb 7 12 alone alone JJ cord-329844-w969lczb 7 13 to to TO cord-329844-w969lczb 7 14 predict predict VB cord-329844-w969lczb 7 15 domains domain NNS cord-329844-w969lczb 7 16 or or CC cord-329844-w969lczb 7 17 proteins protein NNS cord-329844-w969lczb 7 18 that that WDT cord-329844-w969lczb 7 19 bind bind VBP cord-329844-w969lczb 7 20 to to IN cord-329844-w969lczb 7 21 sialic sialic JJ cord-329844-w969lczb 7 22 acids acid NNS cord-329844-w969lczb 7 23 , , , cord-329844-w969lczb 7 24 is be VBZ cord-329844-w969lczb 7 25 naïve naïve JJ cord-329844-w969lczb 7 26 , , , cord-329844-w969lczb 7 27 and and CC cord-329844-w969lczb 7 28 will will MD cord-329844-w969lczb 7 29 be be VB cord-329844-w969lczb 7 30 advanced advance VBN cord-329844-w969lczb 7 31 in in IN cord-329844-w969lczb 7 32 future future JJ cord-329844-w969lczb 7 33 work work NN cord-329844-w969lczb 7 34 . . . cord-329844-w969lczb 8 1 Nonetheless nonetheless RB cord-329844-w969lczb 8 2 , , , cord-329844-w969lczb 8 3 it -PRON- PRP cord-329844-w969lczb 8 4 was be VBD cord-329844-w969lczb 8 5 surprising surprising JJ cord-329844-w969lczb 8 6 that that IN cord-329844-w969lczb 8 7 such such PDT cord-329844-w969lczb 8 8 a a DT cord-329844-w969lczb 8 9 very very RB cord-329844-w969lczb 8 10 simple simple JJ cord-329844-w969lczb 8 11 approach approach NN cord-329844-w969lczb 8 12 was be VBD cord-329844-w969lczb 8 13 so so RB cord-329844-w969lczb 8 14 useful useful JJ cord-329844-w969lczb 8 15 , , , cord-329844-w969lczb 8 16 and and CC cord-329844-w969lczb 8 17 it -PRON- PRP cord-329844-w969lczb 8 18 can can MD cord-329844-w969lczb 8 19 easily easily RB cord-329844-w969lczb 8 20 be be VB cord-329844-w969lczb 8 21 reproduced reproduce VBN cord-329844-w969lczb 8 22 in in IN cord-329844-w969lczb 8 23 a a DT cord-329844-w969lczb 8 24 very very RB cord-329844-w969lczb 8 25 few few JJ cord-329844-w969lczb 8 26 lines line NNS cord-329844-w969lczb 8 27 of of IN cord-329844-w969lczb 8 28 computer computer NN cord-329844-w969lczb 8 29 program program NN cord-329844-w969lczb 8 30 to to TO cord-329844-w969lczb 8 31 help help VB cord-329844-w969lczb 8 32 make make VB cord-329844-w969lczb 8 33 quick quick JJ cord-329844-w969lczb 8 34 comparisons comparison NNS cord-329844-w969lczb 8 35 between between IN cord-329844-w969lczb 8 36 SARS SARS NNP cord-329844-w969lczb 8 37 - - HYPH cord-329844-w969lczb 8 38 CoV-2 CoV-2 NNP cord-329844-w969lczb 8 39 sequences sequence NNS cord-329844-w969lczb 8 40 and and CC cord-329844-w969lczb 8 41 to to TO cord-329844-w969lczb 8 42 consider consider VB cord-329844-w969lczb 8 43 the the DT cord-329844-w969lczb 8 44 effects effect NNS cord-329844-w969lczb 8 45 of of IN cord-329844-w969lczb 8 46 viral viral JJ cord-329844-w969lczb 8 47 mutations mutation NNS cord-329844-w969lczb 8 48 . . . cord-329844-w969lczb 9 1 As as RB cord-329844-w969lczb 9 2 far far RB cord-329844-w969lczb 9 3 as as IN cord-329844-w969lczb 9 4 is be VBZ cord-329844-w969lczb 9 5 known know VBN cord-329844-w969lczb 9 6 to to IN cord-329844-w969lczb 9 7 history history NN cord-329844-w969lczb 9 8 , , , cord-329844-w969lczb 9 9 no no DT cord-329844-w969lczb 9 10 coronavirus coronavirus NN cord-329844-w969lczb 9 11 [ [ -LRB- cord-329844-w969lczb 9 12 1 1 CD cord-329844-w969lczb 9 13 ] ] -RRB- cord-329844-w969lczb 9 14 has have VBZ cord-329844-w969lczb 9 15 been be VBN cord-329844-w969lczb 9 16 as as RB cord-329844-w969lczb 9 17 disturbing disturbing JJ cord-329844-w969lczb 9 18 to to IN cord-329844-w969lczb 9 19 humanity humanity NN cord-329844-w969lczb 9 20 as as IN cord-329844-w969lczb 9 21 the the DT cord-329844-w969lczb 9 22 human human JJ cord-329844-w969lczb 9 23 pandemic pandemic NN cord-329844-w969lczb 9 24 of of IN cord-329844-w969lczb 9 25 the the DT cord-329844-w969lczb 9 26 2019 2019 CD cord-329844-w969lczb 9 27 novel novel NN cord-329844-w969lczb 9 28 coronavirus coronavirus NN cord-329844-w969lczb 9 29 [ [ -LRB- cord-329844-w969lczb 9 30 2 2 CD cord-329844-w969lczb 9 31 ] ] -RRB- cord-329844-w969lczb 9 32 now now RB cord-329844-w969lczb 9 33 known know VBN cord-329844-w969lczb 9 34 as as IN cord-329844-w969lczb 9 35 SARS SARS NNP cord-329844-w969lczb 9 36 - - HYPH cord-329844-w969lczb 9 37 CoV-2 CoV-2 NNP cord-329844-w969lczb 9 38 . . . cord-329844-w969lczb 10 1 In in IN cord-329844-w969lczb 10 2 quick quick JJ cord-329844-w969lczb 10 3 response response NN cord-329844-w969lczb 10 4 to to IN cord-329844-w969lczb 10 5 determination determination NN cord-329844-w969lczb 10 6 of of IN cord-329844-w969lczb 10 7 the the DT cord-329844-w969lczb 10 8 final final JJ cord-329844-w969lczb 10 9 version version NN cord-329844-w969lczb 10 10 of of IN cord-329844-w969lczb 10 11 the the DT cord-329844-w969lczb 10 12 RNA RNA NNP cord-329844-w969lczb 10 13 sequence sequence NN cord-329844-w969lczb 10 14 of of IN cord-329844-w969lczb 10 15 the the DT cord-329844-w969lczb 10 16 Wuhan Wuhan NNP cord-329844-w969lczb 10 17 seafood seafood NN cord-329844-w969lczb 10 18 market market NN cord-329844-w969lczb 10 19 isolate isolate VBP cord-329844-w969lczb 10 20 , , , cord-329844-w969lczb 10 21 the the DT cord-329844-w969lczb 10 22 present present JJ cord-329844-w969lczb 10 23 author author NN cord-329844-w969lczb 10 24 examined examine VBD cord-329844-w969lczb 10 25 functional functional JJ cord-329844-w969lczb 10 26 sites site NNS cord-329844-w969lczb 10 27 of of IN cord-329844-w969lczb 10 28 SARS SARS NNP cord-329844-w969lczb 10 29 - - : cord-329844-w969lczb 10 30 CoV-2 CoV-2 NNP cord-329844-w969lczb 10 31 that that WDT cord-329844-w969lczb 10 32 are be VBP cord-329844-w969lczb 10 33 highly highly RB cord-329844-w969lczb 10 34 conserved conserve VBN cord-329844-w969lczb 10 35 across across IN cord-329844-w969lczb 10 36 the the DT cord-329844-w969lczb 10 37 coronaviruses coronaviruse NNS cord-329844-w969lczb 10 38 [ [ -LRB- cord-329844-w969lczb 10 39 3 3 CD cord-329844-w969lczb 10 40 , , , cord-329844-w969lczb 10 41 4 4 CD cord-329844-w969lczb 10 42 ] ] -RRB- cord-329844-w969lczb 10 43 , , , cord-329844-w969lczb 10 44 and and CC cord-329844-w969lczb 10 45 which which WDT cord-329844-w969lczb 10 46 thus thus RB cord-329844-w969lczb 10 47 likely likely JJ cord-329844-w969lczb 10 48 to to TO cord-329844-w969lczb 10 49 exhibit exhibit VB cord-329844-w969lczb 10 50 escape escape NN cord-329844-w969lczb 10 51 mutation mutation NN cord-329844-w969lczb 10 52 that that WDT cord-329844-w969lczb 10 53 can can MD cord-329844-w969lczb 10 54 quickly quickly RB cord-329844-w969lczb 10 55 undo undo VB cord-329844-w969lczb 10 56 the the DT cord-329844-w969lczb 10 57 good good JJ cord-329844-w969lczb 10 58 work work NN cord-329844-w969lczb 10 59 of of IN cord-329844-w969lczb 10 60 the the DT cord-329844-w969lczb 10 61 developers developer NNS cord-329844-w969lczb 10 62 of of IN cord-329844-w969lczb 10 63 vaccines vaccine NNS cord-329844-w969lczb 10 64 and and CC cord-329844-w969lczb 10 65 therapeutic therapeutic JJ cord-329844-w969lczb 10 66 agents agent NNS cord-329844-w969lczb 10 67 . . . cord-329844-w969lczb 11 1 So so RB cord-329844-w969lczb 11 2 far far RB cord-329844-w969lczb 11 3 , , , cord-329844-w969lczb 11 4 the the DT cord-329844-w969lczb 11 5 published publish VBN cord-329844-w969lczb 11 6 papers paper NNS cord-329844-w969lczb 11 7 have have VBP cord-329844-w969lczb 11 8 concerned concern VBN cord-329844-w969lczb 11 9 the the DT cord-329844-w969lczb 11 10 spike spike NN cord-329844-w969lczb 11 11 glycoprotein glycoprotein NN cord-329844-w969lczb 11 12 [ [ -LRB- cord-329844-w969lczb 11 13 3 3 CD cord-329844-w969lczb 11 14 ] ] -RRB- cord-329844-w969lczb 11 15 [ [ -LRB- cord-329844-w969lczb 11 16 4 4 CD cord-329844-w969lczb 11 17 ] ] -RRB- cord-329844-w969lczb 11 18 [ [ -LRB- cord-329844-w969lczb 11 19 5 5 CD cord-329844-w969lczb 11 20 ] ] -RRB- cord-329844-w969lczb 11 21 . . . cord-329844-w969lczb 12 1 Exploration exploration NN cord-329844-w969lczb 12 2 of of IN cord-329844-w969lczb 12 3 known know VBN cord-329844-w969lczb 12 4 and and CC cord-329844-w969lczb 12 5 newly newly RB cord-329844-w969lczb 12 6 found find VBN cord-329844-w969lczb 12 7 proteolytic proteolytic JJ cord-329844-w969lczb 12 8 cleavage cleavage NN cord-329844-w969lczb 12 9 sites site NNS cord-329844-w969lczb 12 10 in in IN cord-329844-w969lczb 12 11 the the DT cord-329844-w969lczb 12 12 spike spike NN cord-329844-w969lczb 12 13 glycoprotein glycoprotein NN cord-329844-w969lczb 12 14 of of IN cord-329844-w969lczb 12 15 SARS SARS NNP cord-329844-w969lczb 12 16 - - : cord-329844-w969lczb 12 17 CoV-2 CoV-2 NNP cord-329844-w969lczb 12 18 that that WDT cord-329844-w969lczb 12 19 are be VBP cord-329844-w969lczb 12 20 well well RB cord-329844-w969lczb 12 21 conserved conserved JJ cord-329844-w969lczb 12 22 is be VBZ cord-329844-w969lczb 12 23 a a DT cord-329844-w969lczb 12 24 popular popular JJ cord-329844-w969lczb 12 25 area area NN cord-329844-w969lczb 12 26 of of IN cord-329844-w969lczb 12 27 inquiry inquiry NN cord-329844-w969lczb 12 28 for for IN cord-329844-w969lczb 12 29 SARS SARS NNP cord-329844-w969lczb 12 30 researchers researcher NNS cord-329844-w969lczb 12 31 because because IN cord-329844-w969lczb 12 32 such such JJ cord-329844-w969lczb 12 33 sites site NNS cord-329844-w969lczb 12 34 can can MD cord-329844-w969lczb 12 35 interact interact VB cord-329844-w969lczb 12 36 with with IN cord-329844-w969lczb 12 37 human human JJ cord-329844-w969lczb 12 38 host host NN cord-329844-w969lczb 12 39 airway airway NN cord-329844-w969lczb 12 40 proteases protease NNS cord-329844-w969lczb 12 41 that that WDT cord-329844-w969lczb 12 42 could could MD cord-329844-w969lczb 12 43 be be VB cord-329844-w969lczb 12 44 the the DT cord-329844-w969lczb 12 45 target target NN cord-329844-w969lczb 12 46 for for IN cord-329844-w969lczb 12 47 protease protease NN cord-329844-w969lczb 12 48 inhibitors inhibitor NNS cord-329844-w969lczb 12 49 as as IN cord-329844-w969lczb 12 50 potential potential JJ cord-329844-w969lczb 12 51 drugs drug NNS cord-329844-w969lczb 12 52 ( ( -LRB- cord-329844-w969lczb 12 53 e.g. e.g. RB cord-329844-w969lczb 12 54 Ref Ref NNP cord-329844-w969lczb 12 55 [ [ -LRB- cord-329844-w969lczb 12 56 6 6 CD cord-329844-w969lczb 12 57 ] ] -RRB- cord-329844-w969lczb 12 58 ) ) -RRB- cord-329844-w969lczb 12 59 . . . cord-329844-w969lczb 13 1 The the DT cord-329844-w969lczb 13 2 difficulty difficulty NN cord-329844-w969lczb 13 3 is be VBZ cord-329844-w969lczb 13 4 that that IN cord-329844-w969lczb 13 5 inhibiting inhibit VBG cord-329844-w969lczb 13 6 the the DT cord-329844-w969lczb 13 7 action action NN cord-329844-w969lczb 13 8 of of IN cord-329844-w969lczb 13 9 human human JJ cord-329844-w969lczb 13 10 proteins protein NNS cord-329844-w969lczb 13 11 could could MD cord-329844-w969lczb 13 12 have have VB cord-329844-w969lczb 13 13 undesirable undesirable JJ cord-329844-w969lczb 13 14 effects effect NNS cord-329844-w969lczb 13 15 on on IN cord-329844-w969lczb 13 16 the the DT cord-329844-w969lczb 13 17 host host NN cord-329844-w969lczb 13 18 [ [ -LRB- cord-329844-w969lczb 13 19 6 6 CD cord-329844-w969lczb 13 20 ] ] -RRB- cord-329844-w969lczb 13 21 , , , cord-329844-w969lczb 13 22 so so IN cord-329844-w969lczb 13 23 parallel parallel JJ cord-329844-w969lczb 13 24 work work NN cord-329844-w969lczb 13 25 on on IN cord-329844-w969lczb 13 26 other other JJ cord-329844-w969lczb 13 27 kinds kind NNS cord-329844-w969lczb 13 28 of of IN cord-329844-w969lczb 13 29 functional functional JJ cord-329844-w969lczb 13 30 sites site NNS cord-329844-w969lczb 13 31 in in IN cord-329844-w969lczb 13 32 the the DT cord-329844-w969lczb 13 33 coronavirus coronavirus NN cord-329844-w969lczb 13 34 proteins protein NNS cord-329844-w969lczb 13 35 is be VBZ cord-329844-w969lczb 13 36 of of IN cord-329844-w969lczb 13 37 great great JJ cord-329844-w969lczb 13 38 importance importance NN cord-329844-w969lczb 13 39 . . . cord-329844-w969lczb 14 1 The the DT cord-329844-w969lczb 14 2 present present JJ cord-329844-w969lczb 14 3 paper paper NN cord-329844-w969lczb 14 4 explores explore VBZ cord-329844-w969lczb 14 5 another another DT cord-329844-w969lczb 14 6 potential potential JJ cord-329844-w969lczb 14 7 functional functional JJ cord-329844-w969lczb 14 8 site site NN cord-329844-w969lczb 14 9 in in IN cord-329844-w969lczb 14 10 the the DT cord-329844-w969lczb 14 11 spike spike NN cord-329844-w969lczb 14 12 protein protein NN cord-329844-w969lczb 14 13 , , , cord-329844-w969lczb 14 14 but but CC cord-329844-w969lczb 14 15 this this DT cord-329844-w969lczb 14 16 one one NN cord-329844-w969lczb 14 17 is be VBZ cord-329844-w969lczb 14 18 a a DT cord-329844-w969lczb 14 19 different different JJ cord-329844-w969lczb 14 20 because because IN cord-329844-w969lczb 14 21 the the DT cord-329844-w969lczb 14 22 site site NN cord-329844-w969lczb 14 23 is be VBZ cord-329844-w969lczb 14 24 not not RB cord-329844-w969lczb 14 25 a a DT cord-329844-w969lczb 14 26 proteolytic proteolytic JJ cord-329844-w969lczb 14 27 cleavage cleavage NN cord-329844-w969lczb 14 28 site site NN cord-329844-w969lczb 14 29 , , , cord-329844-w969lczb 14 30 and and CC cord-329844-w969lczb 14 31 it -PRON- PRP cord-329844-w969lczb 14 32 is be VBZ cord-329844-w969lczb 14 33 not not RB cord-329844-w969lczb 14 34 well well RB cord-329844-w969lczb 14 35 conserved conserve VBN cord-329844-w969lczb 14 36 , , , cord-329844-w969lczb 14 37 except except IN cord-329844-w969lczb 14 38 , , , cord-329844-w969lczb 14 39 it -PRON- PRP cord-329844-w969lczb 14 40 is be VBZ cord-329844-w969lczb 14 41 argued argue VBN cord-329844-w969lczb 14 42 , , , cord-329844-w969lczb 14 43 for for IN cord-329844-w969lczb 14 44 a a DT cord-329844-w969lczb 14 45 characteristic characteristic JJ cord-329844-w969lczb 14 46 composition composition NN cord-329844-w969lczb 14 47 of of IN cord-329844-w969lczb 14 48 particular particular JJ cord-329844-w969lczb 14 49 amino amino NN cord-329844-w969lczb 14 50 acid acid NN cord-329844-w969lczb 14 51 residues residue NNS cord-329844-w969lczb 14 52 . . . cord-329844-w969lczb 15 1 Expressed express VBD cord-329844-w969lczb 15 2 another another DT cord-329844-w969lczb 15 3 way way NN cord-329844-w969lczb 15 4 , , , cord-329844-w969lczb 15 5 there there EX cord-329844-w969lczb 15 6 can can MD cord-329844-w969lczb 15 7 exist exist VB cord-329844-w969lczb 15 8 certain certain JJ cord-329844-w969lczb 15 9 subsequences subsequence NNS cord-329844-w969lczb 15 10 of of IN cord-329844-w969lczb 15 11 a a DT cord-329844-w969lczb 15 12 protein protein NN cord-329844-w969lczb 15 13 sequence sequence NN cord-329844-w969lczb 15 14 that that WDT cord-329844-w969lczb 15 15 are be VBP cord-329844-w969lczb 15 16 well well RB cord-329844-w969lczb 15 17 conserved conserved JJ cord-329844-w969lczb 15 18 , , , cord-329844-w969lczb 15 19 but but CC cord-329844-w969lczb 15 20 only only RB cord-329844-w969lczb 15 21 in in IN cord-329844-w969lczb 15 22 respect respect NN cord-329844-w969lczb 15 23 to to IN cord-329844-w969lczb 15 24 some some DT cord-329844-w969lczb 15 25 pattern pattern NN cord-329844-w969lczb 15 26 or or CC cord-329844-w969lczb 15 27 property property NN cord-329844-w969lczb 15 28 that that WDT cord-329844-w969lczb 15 29 is be VBZ cord-329844-w969lczb 15 30 less less RBR cord-329844-w969lczb 15 31 obvious obvious JJ cord-329844-w969lczb 15 32 than than IN cord-329844-w969lczb 15 33 the the DT cord-329844-w969lczb 15 34 order order NN cord-329844-w969lczb 15 35 of of IN cord-329844-w969lczb 15 36 amino amino JJ cord-329844-w969lczb 15 37 acids acid NNS cord-329844-w969lczb 15 38 . . . cord-329844-w969lczb 16 1 Finding find VBG cord-329844-w969lczb 16 2 them -PRON- PRP cord-329844-w969lczb 16 3 ( ( -LRB- cord-329844-w969lczb 16 4 or or CC cord-329844-w969lczb 16 5 as as IN cord-329844-w969lczb 16 6 is be VBZ cord-329844-w969lczb 16 7 more more RBR cord-329844-w969lczb 16 8 correctly correctly RB cord-329844-w969lczb 16 9 stated state VBN cord-329844-w969lczb 16 10 , , , cord-329844-w969lczb 16 11 predicting predict VBG cord-329844-w969lczb 16 12 them -PRON- PRP cord-329844-w969lczb 16 13 ) ) -RRB- cord-329844-w969lczb 16 14 may may MD cord-329844-w969lczb 16 15 therefore therefore RB cord-329844-w969lczb 16 16 require require VB cord-329844-w969lczb 16 17 a a DT cord-329844-w969lczb 16 18 more more RBR cord-329844-w969lczb 16 19 subtle subtle JJ cord-329844-w969lczb 16 20 and and CC cord-329844-w969lczb 16 21 , , , cord-329844-w969lczb 16 22 in in IN cord-329844-w969lczb 16 23 the the DT cord-329844-w969lczb 16 24 present present JJ cord-329844-w969lczb 16 25 case case NN cord-329844-w969lczb 16 26 , , , cord-329844-w969lczb 16 27 novel novel JJ cord-329844-w969lczb 16 28 bioinformatics bioinformatics NN cord-329844-w969lczb 16 29 tool tool NN cord-329844-w969lczb 16 30 , , , cord-329844-w969lczb 16 31 compared compare VBN cord-329844-w969lczb 16 32 with with IN cord-329844-w969lczb 16 33 the the DT cord-329844-w969lczb 16 34 standard standard JJ cord-329844-w969lczb 16 35 bioinformatics bioinformatics NN cord-329844-w969lczb 16 36 tools tool NNS cord-329844-w969lczb 16 37 which which WDT cord-329844-w969lczb 16 38 were be VBD cord-329844-w969lczb 16 39 essential essential JJ cord-329844-w969lczb 16 40 in in IN cord-329844-w969lczb 16 41 the the DT cord-329844-w969lczb 16 42 preceding precede VBG cord-329844-w969lczb 16 43 papers paper NNS cord-329844-w969lczb 16 44 [ [ -LRB- cord-329844-w969lczb 16 45 3 3 CD cord-329844-w969lczb 16 46 ] ] -RRB- cord-329844-w969lczb 16 47 [ [ -LRB- cord-329844-w969lczb 16 48 4 4 CD cord-329844-w969lczb 16 49 ] ] -RRB- cord-329844-w969lczb 16 50 [ [ -LRB- cord-329844-w969lczb 16 51 5 5 CD cord-329844-w969lczb 16 52 ] ] -RRB- cord-329844-w969lczb 16 53 . . . cord-329844-w969lczb 17 1 Comparisons comparison NNS cord-329844-w969lczb 17 2 with with IN cord-329844-w969lczb 17 3 other other JJ cord-329844-w969lczb 17 4 proteins protein NNS cord-329844-w969lczb 17 5 as as IN cord-329844-w969lczb 17 6 described describe VBN cord-329844-w969lczb 17 7 below below RB cord-329844-w969lczb 17 8 suggest suggest VBP cord-329844-w969lczb 17 9 that that IN cord-329844-w969lczb 17 10 the the DT cord-329844-w969lczb 17 11 subsequence subsequence NN cord-329844-w969lczb 17 12 of of IN cord-329844-w969lczb 17 13 interest interest NN cord-329844-w969lczb 17 14 in in IN cord-329844-w969lczb 17 15 this this DT cord-329844-w969lczb 17 16 paper paper NN cord-329844-w969lczb 17 17 could could MD cord-329844-w969lczb 17 18 have have VB cord-329844-w969lczb 17 19 a a DT cord-329844-w969lczb 17 20 crucial crucial JJ cord-329844-w969lczb 17 21 function function NN cord-329844-w969lczb 17 22 , , , cord-329844-w969lczb 17 23 and and CC cord-329844-w969lczb 17 24 a a DT cord-329844-w969lczb 17 25 high high JJ cord-329844-w969lczb 17 26 degree degree NN cord-329844-w969lczb 17 27 of of IN cord-329844-w969lczb 17 28 conservation conservation NN cord-329844-w969lczb 17 29 is be VBZ cord-329844-w969lczb 17 30 , , , cord-329844-w969lczb 17 31 even even RB cord-329844-w969lczb 17 32 by by IN cord-329844-w969lczb 17 33 itself -PRON- PRP cord-329844-w969lczb 17 34 , , , cord-329844-w969lczb 17 35 also also RB cord-329844-w969lczb 17 36 a a DT cord-329844-w969lczb 17 37 clue clue NN cord-329844-w969lczb 17 38 as as IN cord-329844-w969lczb 17 39 having have VBG cord-329844-w969lczb 17 40 a a DT cord-329844-w969lczb 17 41 role role NN cord-329844-w969lczb 17 42 important important JJ cord-329844-w969lczb 17 43 to to IN cord-329844-w969lczb 17 44 the the DT cord-329844-w969lczb 17 45 virus virus NN cord-329844-w969lczb 17 46 [ [ -LRB- cord-329844-w969lczb 17 47 5 5 CD cord-329844-w969lczb 17 48 ] ] -RRB- cord-329844-w969lczb 17 49 . . . cord-329844-w969lczb 18 1 Hence hence RB cord-329844-w969lczb 18 2 such such PDT cord-329844-w969lczb 18 3 a a DT cord-329844-w969lczb 18 4 site site NN cord-329844-w969lczb 18 5 may may MD cord-329844-w969lczb 18 6 represent represent VB cord-329844-w969lczb 18 7 a a DT cord-329844-w969lczb 18 8 potential potential JJ cord-329844-w969lczb 18 9 therapeutic therapeutic JJ cord-329844-w969lczb 18 10 target target NN cord-329844-w969lczb 18 11 , , , cord-329844-w969lczb 18 12 perhaps perhaps RB cord-329844-w969lczb 18 13 as as RB cord-329844-w969lczb 18 14 well well RB cord-329844-w969lczb 18 15 as as IN cord-329844-w969lczb 18 16 representing represent VBG cord-329844-w969lczb 18 17 a a DT cord-329844-w969lczb 18 18 synthetic synthetic JJ cord-329844-w969lczb 18 19 vaccine vaccine NN cord-329844-w969lczb 18 20 target target NN cord-329844-w969lczb 18 21 . . . cord-329844-w969lczb 19 1 However however RB cord-329844-w969lczb 19 2 , , , cord-329844-w969lczb 19 3 until until IN cord-329844-w969lczb 19 4 very very RB cord-329844-w969lczb 19 5 recently recently RB cord-329844-w969lczb 19 6 , , , cord-329844-w969lczb 19 7 that that IN cord-329844-w969lczb 19 8 crucial crucial JJ cord-329844-w969lczb 19 9 function function NN cord-329844-w969lczb 19 10 did do VBD cord-329844-w969lczb 19 11 not not RB cord-329844-w969lczb 19 12 even even RB cord-329844-w969lczb 19 13 seem seem VB cord-329844-w969lczb 19 14 to to TO cord-329844-w969lczb 19 15 be be VB cord-329844-w969lczb 19 16 possessed possess VBN cord-329844-w969lczb 19 17 by by IN cord-329844-w969lczb 19 18 SARS SARS NNP cord-329844-w969lczb 19 19 - - HYPH cord-329844-w969lczb 19 20 CoV CoV NNP cord-329844-w969lczb 19 21 and and CC cord-329844-w969lczb 19 22 SARS SARS NNP cord-329844-w969lczb 19 23 - - HYPH cord-329844-w969lczb 19 24 CoV-2 CoV-2 NNP cord-329844-w969lczb 19 25 , , , cord-329844-w969lczb 19 26 and and CC cord-329844-w969lczb 19 27 the the DT cord-329844-w969lczb 19 28 details detail NNS cord-329844-w969lczb 19 29 have have VBP cord-329844-w969lczb 19 30 yet yet RB cord-329844-w969lczb 19 31 to to TO cord-329844-w969lczb 19 32 be be VB cord-329844-w969lczb 19 33 elucidated elucidate VBN cord-329844-w969lczb 19 34 . . . cord-329844-w969lczb 20 1 The the DT cord-329844-w969lczb 20 2 particular particular JJ cord-329844-w969lczb 20 3 virus virus NN cord-329844-w969lczb 20 4 function function NN cord-329844-w969lczb 20 5 that that WDT cord-329844-w969lczb 20 6 is be VBZ cord-329844-w969lczb 20 7 considered consider VBN cord-329844-w969lczb 20 8 in in IN cord-329844-w969lczb 20 9 the the DT cord-329844-w969lczb 20 10 present present JJ cord-329844-w969lczb 20 11 paper paper NN cord-329844-w969lczb 20 12 is be VBZ cord-329844-w969lczb 20 13 noncovalent noncovalent NN cord-329844-w969lczb 20 14 binding bind VBG cord-329844-w969lczb 20 15 to to IN cord-329844-w969lczb 20 16 the the DT cord-329844-w969lczb 20 17 sialic sialic JJ cord-329844-w969lczb 20 18 acid acid NN cord-329844-w969lczb 20 19 glycans glycan NNS cord-329844-w969lczb 20 20 , , , cord-329844-w969lczb 20 21 i.e. i.e. FW cord-329844-w969lczb 20 22 oligosaccharides oligosaccharide NNS cord-329844-w969lczb 20 23 or or CC cord-329844-w969lczb 20 24 polysaccharides polysaccharide NNS cord-329844-w969lczb 20 25 that that WDT cord-329844-w969lczb 20 26 contain contain VBP cord-329844-w969lczb 20 27 sialic sialic JJ cord-329844-w969lczb 20 28 acid acid NN cord-329844-w969lczb 20 29 residues residue NNS cord-329844-w969lczb 20 30 . . . cord-329844-w969lczb 21 1 They -PRON- PRP cord-329844-w969lczb 21 2 are be VBP cord-329844-w969lczb 21 3 sometimes sometimes RB cord-329844-w969lczb 21 4 called call VBN cord-329844-w969lczb 21 5 sialylated sialylate VBN cord-329844-w969lczb 21 6 glycans glycan NNS cord-329844-w969lczb 21 7 . . . cord-329844-w969lczb 22 1 Interest interest NN cord-329844-w969lczb 22 2 in in IN cord-329844-w969lczb 22 3 this this DT cord-329844-w969lczb 22 4 binding binding NN cord-329844-w969lczb 22 5 arose arise VBD cord-329844-w969lczb 22 6 as as IN cord-329844-w969lczb 22 7 follows follow VBZ cord-329844-w969lczb 22 8 . . . cord-329844-w969lczb 23 1 It -PRON- PRP cord-329844-w969lczb 23 2 seems seem VBZ cord-329844-w969lczb 23 3 unlikely unlikely JJ cord-329844-w969lczb 23 4 ( ( -LRB- cord-329844-w969lczb 23 5 although although IN cord-329844-w969lczb 23 6 of of IN cord-329844-w969lczb 23 7 course course NN cord-329844-w969lczb 23 8 possible possible JJ cord-329844-w969lczb 23 9 ) ) -RRB- cord-329844-w969lczb 23 10 that that WDT cord-329844-w969lczb 23 11 functions function VBZ cord-329844-w969lczb 23 12 important important JJ cord-329844-w969lczb 23 13 for for IN cord-329844-w969lczb 23 14 many many JJ cord-329844-w969lczb 23 15 different different JJ cord-329844-w969lczb 23 16 kinds kind NNS cord-329844-w969lczb 23 17 of of IN cord-329844-w969lczb 23 18 virus virus NN cord-329844-w969lczb 23 19 are be VBP cord-329844-w969lczb 23 20 of of IN cord-329844-w969lczb 23 21 little little JJ cord-329844-w969lczb 23 22 importance importance NN cord-329844-w969lczb 23 23 to to IN cord-329844-w969lczb 23 24 others other NNS cord-329844-w969lczb 23 25 , , , cord-329844-w969lczb 23 26 especially especially RB cord-329844-w969lczb 23 27 if if IN cord-329844-w969lczb 23 28 they -PRON- PRP cord-329844-w969lczb 23 29 have have VBP cord-329844-w969lczb 23 30 a a DT cord-329844-w969lczb 23 31 common common JJ cord-329844-w969lczb 23 32 lifestyle lifestyle NN cord-329844-w969lczb 23 33 such such JJ cord-329844-w969lczb 23 34 as as IN cord-329844-w969lczb 23 35 infection infection NN cord-329844-w969lczb 23 36 of of IN cord-329844-w969lczb 23 37 the the DT cord-329844-w969lczb 23 38 respiratory respiratory JJ cord-329844-w969lczb 23 39 system system NN cord-329844-w969lczb 23 40 or or CC cord-329844-w969lczb 23 41 alimentary alimentary JJ cord-329844-w969lczb 23 42 tract tract NN cord-329844-w969lczb 23 43 , , , cord-329844-w969lczb 23 44 typically typically RB cord-329844-w969lczb 23 45 reflected reflect VBN cord-329844-w969lczb 23 46 by by IN cord-329844-w969lczb 23 47 common common JJ cord-329844-w969lczb 23 48 symptoms symptom NNS cord-329844-w969lczb 23 49 . . . cord-329844-w969lczb 24 1 If if IN cord-329844-w969lczb 24 2 such such JJ cord-329844-w969lczb 24 3 functions function NNS cord-329844-w969lczb 24 4 are be VBP cord-329844-w969lczb 24 5 absent absent JJ cord-329844-w969lczb 24 6 , , , cord-329844-w969lczb 24 7 it -PRON- PRP cord-329844-w969lczb 24 8 begs beg VBZ cord-329844-w969lczb 24 9 the the DT cord-329844-w969lczb 24 10 question question NN cord-329844-w969lczb 24 11 of of IN cord-329844-w969lczb 24 12 how how WRB cord-329844-w969lczb 24 13 the the DT cord-329844-w969lczb 24 14 virus virus NN cord-329844-w969lczb 24 15 copes cope VBZ cord-329844-w969lczb 24 16 . . . cord-329844-w969lczb 25 1 Though though IN cord-329844-w969lczb 25 2 glycan glycan NN cord-329844-w969lczb 25 3 binding binding NN cord-329844-w969lczb 25 4 of of IN cord-329844-w969lczb 25 5 SARS SARS NNP cord-329844-w969lczb 25 6 - - HYPH cord-329844-w969lczb 25 7 CoV CoV NNP cord-329844-w969lczb 25 8 and and CC cord-329844-w969lczb 25 9 SARS SARS NNP cord-329844-w969lczb 25 10 - - HYPH cord-329844-w969lczb 25 11 CoV-2 CoV-2 NNP cord-329844-w969lczb 25 12 seems seem VBZ cord-329844-w969lczb 25 13 absent absent JJ cord-329844-w969lczb 25 14 , , , cord-329844-w969lczb 25 15 diminished diminish VBN cord-329844-w969lczb 25 16 , , , cord-329844-w969lczb 25 17 or or CC cord-329844-w969lczb 25 18 relatively relatively RB cord-329844-w969lczb 25 19 neglected neglected JJ cord-329844-w969lczb 25 20 in in IN cord-329844-w969lczb 25 21 the the DT cord-329844-w969lczb 25 22 literature literature NN cord-329844-w969lczb 25 23 ( ( -LRB- cord-329844-w969lczb 25 24 see see VB cord-329844-w969lczb 25 25 Section Section NNP cord-329844-w969lczb 25 26 1.5 1.5 CD cord-329844-w969lczb 25 27 ) ) -RRB- cord-329844-w969lczb 25 28 , , , cord-329844-w969lczb 25 29 many many JJ cord-329844-w969lczb 25 30 coronaviruses coronaviruse NNS cord-329844-w969lczb 25 31 such such JJ cord-329844-w969lczb 25 32 as as IN cord-329844-w969lczb 25 33 human human JJ cord-329844-w969lczb 25 34 coronavirus coronavirus NN cord-329844-w969lczb 25 35 OC43 OC43 NNP cord-329844-w969lczb 25 36 and and CC cord-329844-w969lczb 25 37 bovine bovine JJ cord-329844-w969lczb 25 38 coronavirus coronavirus NN cord-329844-w969lczb 25 39 appear appear VBP cord-329844-w969lczb 25 40 to to TO cord-329844-w969lczb 25 41 recognize recognize VB cord-329844-w969lczb 25 42 sialic sialic JJ cord-329844-w969lczb 25 43 acid acid NN cord-329844-w969lczb 25 44 as as IN cord-329844-w969lczb 25 45 a a DT cord-329844-w969lczb 25 46 receptor receptor NN cord-329844-w969lczb 25 47 . . . cord-329844-w969lczb 26 1 However however RB cord-329844-w969lczb 26 2 , , , cord-329844-w969lczb 26 3 most most JJS cord-329844-w969lczb 26 4 biology biology NN cord-329844-w969lczb 26 5 students student NNS cord-329844-w969lczb 26 6 are be VBP cord-329844-w969lczb 26 7 more more RBR cord-329844-w969lczb 26 8 familiar familiar JJ cord-329844-w969lczb 26 9 with with IN cord-329844-w969lczb 26 10 the the DT cord-329844-w969lczb 26 11 hemagglutinin hemagglutinin NN cord-329844-w969lczb 26 12 and and CC cord-329844-w969lczb 26 13 neuraminidase neuraminidase NN cord-329844-w969lczb 26 14 of of IN cord-329844-w969lczb 26 15 influenza influenza NN cord-329844-w969lczb 26 16 , , , cord-329844-w969lczb 26 17 the the DT cord-329844-w969lczb 26 18 H H NNP cord-329844-w969lczb 26 19 and and CC cord-329844-w969lczb 26 20 N N NNP cord-329844-w969lczb 26 21 in in RB cord-329844-w969lczb 26 22 , , , cord-329844-w969lczb 26 23 for for IN cord-329844-w969lczb 26 24 example example NN cord-329844-w969lczb 26 25 H1N1 H1N1 NNP cord-329844-w969lczb 26 26 ( ( -LRB- cord-329844-w969lczb 26 27 the the DT cord-329844-w969lczb 26 28 numbers number NNS cord-329844-w969lczb 26 29 such such JJ cord-329844-w969lczb 26 30 as as IN cord-329844-w969lczb 26 31 1 1 CD cord-329844-w969lczb 26 32 being be VBG cord-329844-w969lczb 26 33 based base VBN cord-329844-w969lczb 26 34 on on IN cord-329844-w969lczb 26 35 immunological immunological JJ cord-329844-w969lczb 26 36 typing typing NN cord-329844-w969lczb 26 37 of of IN cord-329844-w969lczb 26 38 these these DT cord-329844-w969lczb 26 39 proteins protein NNS cord-329844-w969lczb 26 40 ) ) -RRB- cord-329844-w969lczb 26 41 , , , cord-329844-w969lczb 26 42 that that WDT cord-329844-w969lczb 26 43 bind bind VBP cord-329844-w969lczb 26 44 to to IN cord-329844-w969lczb 26 45 glycans glycan NNS cord-329844-w969lczb 26 46 , , , cord-329844-w969lczb 26 47 ( ( -LRB- cord-329844-w969lczb 26 48 sugar sugar NN cord-329844-w969lczb 26 49 chains chain NNS cord-329844-w969lczb 26 50 , , , cord-329844-w969lczb 26 51 oligosaccharides oligosaccharide NNS cord-329844-w969lczb 26 52 or or CC cord-329844-w969lczb 26 53 polysaccharides polysaccharide NNS cord-329844-w969lczb 26 54 ) ) -RRB- cord-329844-w969lczb 26 55 at at IN cord-329844-w969lczb 26 56 cell cell NN cord-329844-w969lczb 26 57 surfaces surface NNS cord-329844-w969lczb 26 58 notably notably RB cord-329844-w969lczb 26 59 those those DT cord-329844-w969lczb 26 60 chemically chemically RB cord-329844-w969lczb 26 61 bound bind VBN cord-329844-w969lczb 26 62 to to IN cord-329844-w969lczb 26 63 membrane membrane NN cord-329844-w969lczb 26 64 proteins protein NNS cord-329844-w969lczb 26 65 , , , cord-329844-w969lczb 26 66 hence hence RB cord-329844-w969lczb 26 67 called call VBD cord-329844-w969lczb 26 68 glycoproteins glycoprotein NNS cord-329844-w969lczb 26 69 , , , cord-329844-w969lczb 26 70 of of IN cord-329844-w969lczb 26 71 host host NN cord-329844-w969lczb 26 72 cells cell NNS cord-329844-w969lczb 26 73 . . . cord-329844-w969lczb 27 1 The the DT cord-329844-w969lczb 27 2 surfaces surface NNS cord-329844-w969lczb 27 3 of of IN cord-329844-w969lczb 27 4 many many JJ cord-329844-w969lczb 27 5 animal animal NN cord-329844-w969lczb 27 6 and and CC cord-329844-w969lczb 27 7 all all RB cord-329844-w969lczb 27 8 by by IN cord-329844-w969lczb 27 9 host host NN cord-329844-w969lczb 27 10 enzymes enzyme NNS cord-329844-w969lczb 27 11 and and CC cord-329844-w969lczb 27 12 so so RB cord-329844-w969lczb 27 13 would would MD cord-329844-w969lczb 27 14 appear appear VB cord-329844-w969lczb 27 15 , , , cord-329844-w969lczb 27 16 again again RB cord-329844-w969lczb 27 17 at at IN cord-329844-w969lczb 27 18 first first JJ cord-329844-w969lczb 27 19 consideration consideration NN cord-329844-w969lczb 27 20 , , , cord-329844-w969lczb 27 21 to to TO cord-329844-w969lczb 27 22 be be VB cord-329844-w969lczb 27 23 more more RBR cord-329844-w969lczb 27 24 specific specific JJ cord-329844-w969lczb 27 25 . . . cord-329844-w969lczb 28 1 Enveloped envelop VBN cord-329844-w969lczb 28 2 viruses virus NNS cord-329844-w969lczb 28 3 such such JJ cord-329844-w969lczb 28 4 as as IN cord-329844-w969lczb 28 5 SARS SARS NNP cord-329844-w969lczb 28 6 - - : cord-329844-w969lczb 28 7 CoV-2 CoV-2 NNP cord-329844-w969lczb 28 8 also also RB cord-329844-w969lczb 28 9 have have VBP cord-329844-w969lczb 28 10 their -PRON- PRP$ cord-329844-w969lczb 28 11 own own JJ cord-329844-w969lczb 28 12 bound bind VBN cord-329844-w969lczb 28 13 sialic sialic NN cord-329844-w969lczb 28 14 acid acid NN cord-329844-w969lczb 28 15 glycans glycan NNS cord-329844-w969lczb 28 16 ( ( -LRB- cord-329844-w969lczb 28 17 the the DT cord-329844-w969lczb 28 18 spike spike NN cord-329844-w969lczb 28 19 protein protein NN cord-329844-w969lczb 28 20 is be VBZ cord-329844-w969lczb 28 21 usually usually RB cord-329844-w969lczb 28 22 referred refer VBN cord-329844-w969lczb 28 23 to to IN cord-329844-w969lczb 28 24 as as IN cord-329844-w969lczb 28 25 the the DT cord-329844-w969lczb 28 26 spike spike NN cord-329844-w969lczb 28 27 glycoprotein glycoprotein NN cord-329844-w969lczb 28 28 ) ) -RRB- cord-329844-w969lczb 28 29 , , , cord-329844-w969lczb 28 30 but but CC cord-329844-w969lczb 28 31 these these DT cord-329844-w969lczb 28 32 are be VBP cord-329844-w969lczb 28 33 of of IN cord-329844-w969lczb 28 34 less less JJR cord-329844-w969lczb 28 35 direct direct JJ cord-329844-w969lczb 28 36 interest interest NN cord-329844-w969lczb 28 37 here here RB cord-329844-w969lczb 28 38 although although IN cord-329844-w969lczb 28 39 they -PRON- PRP cord-329844-w969lczb 28 40 can can MD cord-329844-w969lczb 28 41 clearly clearly RB cord-329844-w969lczb 28 42 influence influence VB cord-329844-w969lczb 28 43 binding binding NN cord-329844-w969lczb 28 44 of of IN cord-329844-w969lczb 28 45 a a DT cord-329844-w969lczb 28 46 virus virus NN cord-329844-w969lczb 28 47 to to IN cord-329844-w969lczb 28 48 various various JJ cord-329844-w969lczb 28 49 receptors receptor NNS cord-329844-w969lczb 28 50 . . . cord-329844-w969lczb 29 1 Despite despite IN cord-329844-w969lczb 29 2 their -PRON- PRP$ cord-329844-w969lczb 29 3 diversity diversity NN cord-329844-w969lczb 29 4 , , , cord-329844-w969lczb 29 5 and and CC cord-329844-w969lczb 29 6 perhaps perhaps RB cord-329844-w969lczb 29 7 because because IN cord-329844-w969lczb 29 8 of of IN cord-329844-w969lczb 29 9 it -PRON- PRP cord-329844-w969lczb 29 10 ( ( -LRB- cord-329844-w969lczb 29 11 i.e. i.e. FW cord-329844-w969lczb 29 12 because because IN cord-329844-w969lczb 29 13 that that DT cord-329844-w969lczb 29 14 diversity diversity NN cord-329844-w969lczb 29 15 implies imply VBZ cord-329844-w969lczb 29 16 more more JJR cord-329844-w969lczb 29 17 information information NN cord-329844-w969lczb 29 18 content content NN cord-329844-w969lczb 29 19 ) ) -RRB- cord-329844-w969lczb 30 1 sialic sialic JJ cord-329844-w969lczb 30 2 acid acid NN cord-329844-w969lczb 30 3 glycans glycan NNS cord-329844-w969lczb 30 4 of of IN cord-329844-w969lczb 30 5 host host NN cord-329844-w969lczb 30 6 cells cell NNS cord-329844-w969lczb 30 7 are be VBP cord-329844-w969lczb 31 1 key key JJ cord-329844-w969lczb 31 2 molecular molecular JJ cord-329844-w969lczb 31 3 recognition recognition NN cord-329844-w969lczb 31 4 features feature VBZ cord-329844-w969lczb 31 5 not not RB cord-329844-w969lczb 31 6 only only RB cord-329844-w969lczb 31 7 for for IN cord-329844-w969lczb 31 8 entry entry NN cord-329844-w969lczb 31 9 of of IN cord-329844-w969lczb 31 10 viruses virus NNS cord-329844-w969lczb 31 11 such such JJ cord-329844-w969lczb 31 12 as as IN cord-329844-w969lczb 31 13 influenza influenza NN cord-329844-w969lczb 31 14 , , , cord-329844-w969lczb 31 15 but but CC cord-329844-w969lczb 31 16 also also RB cord-329844-w969lczb 31 17 in in IN cord-329844-w969lczb 31 18 embryonic embryonic JJ cord-329844-w969lczb 31 19 development development NN cord-329844-w969lczb 31 20 , , , cord-329844-w969lczb 31 21 neurodevelopment neurodevelopment NN cord-329844-w969lczb 31 22 , , , cord-329844-w969lczb 31 23 reprogramming reprogramming NN cord-329844-w969lczb 31 24 , , , cord-329844-w969lczb 31 25 and and CC cord-329844-w969lczb 31 26 oncogenesis oncogenesis NN cord-329844-w969lczb 31 27 . . . cord-329844-w969lczb 32 1 Correctly correctly RB cord-329844-w969lczb 32 2 speaking speak VBG cord-329844-w969lczb 32 3 , , , cord-329844-w969lczb 32 4 even even RB cord-329844-w969lczb 32 5 sialic sialic JJ cord-329844-w969lczb 32 6 acid acid NN cord-329844-w969lczb 32 7 itself -PRON- PRP cord-329844-w969lczb 32 8 is be VBZ cord-329844-w969lczb 32 9 diverse diverse JJ cord-329844-w969lczb 32 10 . . . cord-329844-w969lczb 33 1 It -PRON- PRP cord-329844-w969lczb 33 2 is be VBZ cord-329844-w969lczb 33 3 a a DT cord-329844-w969lczb 33 4 generic generic JJ cord-329844-w969lczb 33 5 term term NN cord-329844-w969lczb 33 6 for for IN cord-329844-w969lczb 33 7 a a DT cord-329844-w969lczb 33 8 family family NN cord-329844-w969lczb 33 9 of of IN cord-329844-w969lczb 33 10 derivatives derivative NNS cord-329844-w969lczb 33 11 of of IN cord-329844-w969lczb 33 12 the the DT cord-329844-w969lczb 33 13 nine nine CD cord-329844-w969lczb 33 14 - - HYPH cord-329844-w969lczb 33 15 carbon carbon NN cord-329844-w969lczb 33 16 sugar sugar NN cord-329844-w969lczb 33 17 neuraminic neuraminic JJ cord-329844-w969lczb 33 18 acid acid NN cord-329844-w969lczb 33 19 . . . cord-329844-w969lczb 34 1 The the DT cord-329844-w969lczb 34 2 sialic sialic JJ cord-329844-w969lczb 34 3 acid acid NN cord-329844-w969lczb 34 4 family family NN cord-329844-w969lczb 34 5 includes include VBZ cord-329844-w969lczb 34 6 some some DT cord-329844-w969lczb 34 7 43 43 CD cord-329844-w969lczb 34 8 derivatives derivative NNS cord-329844-w969lczb 34 9 of of IN cord-329844-w969lczb 34 10 neuraminic neuraminic JJ cord-329844-w969lczb 34 11 acid acid NN cord-329844-w969lczb 34 12 , , , cord-329844-w969lczb 34 13 but but CC cord-329844-w969lczb 34 14 these these DT cord-329844-w969lczb 34 15 acids acid NNS cord-329844-w969lczb 34 16 rarely rarely RB cord-329844-w969lczb 34 17 appear appear VBP cord-329844-w969lczb 34 18 free free JJ cord-329844-w969lczb 34 19 in in IN cord-329844-w969lczb 34 20 nature nature NN cord-329844-w969lczb 34 21 . . . cord-329844-w969lczb 35 1 Members member NNS cord-329844-w969lczb 35 2 include include VBP cord-329844-w969lczb 35 3 N n CD cord-329844-w969lczb 35 4 - - HYPH cord-329844-w969lczb 35 5 acetylneuraminic acetylneuraminic NNP cord-329844-w969lczb 35 6 acid acid NN cord-329844-w969lczb 35 7 , , , cord-329844-w969lczb 35 8 2-keto-3-deoxy 2-keto-3-deoxy CD cord-329844-w969lczb 35 9 - - HYPH cord-329844-w969lczb 35 10 D D NNP cord-329844-w969lczb 35 11 - - HYPH cord-329844-w969lczb 35 12 glycero glycero NNP cord-329844-w969lczb 35 13 - - HYPH cord-329844-w969lczb 35 14 D D NNP cord-329844-w969lczb 35 15 - - HYPH cord-329844-w969lczb 35 16 galactononulosonic galactononulosonic JJ cord-329844-w969lczb 35 17 acid acid NN cord-329844-w969lczb 35 18 , , , cord-329844-w969lczb 35 19 5,7-diamino-3,5,7,9-tetra 5,7-diamino-3,5,7,9-tetra JJ cord-329844-w969lczb 35 20 - - HYPH cord-329844-w969lczb 35 21 deoxy deoxy NN cord-329844-w969lczb 35 22 - - HYPH cord-329844-w969lczb 35 23 D d JJ cord-329844-w969lczb 35 24 - - HYPH cord-329844-w969lczb 35 25 glycero glycero NNP cord-329844-w969lczb 35 26 - - HYPH cord-329844-w969lczb 35 27 D D NNP cord-329844-w969lczb 35 28 - - HYPH cord-329844-w969lczb 35 29 galacto galacto NNP cord-329844-w969lczb 35 30 - - HYPH cord-329844-w969lczb 35 31 nonulosonic nonulosonic NNP cord-329844-w969lczb 35 32 acid acid NN cord-329844-w969lczb 35 33 , , , cord-329844-w969lczb 35 34 and and CC cord-329844-w969lczb 35 35 5,7-diamino-3,5,7,9-tetra 5,7-diamino-3,5,7,9-tetra JJ cord-329844-w969lczb 35 36 - - HYPH cord-329844-w969lczb 35 37 deoxy deoxy NN cord-329844-w969lczb 35 38 - - HYPH cord-329844-w969lczb 35 39 L l NN cord-329844-w969lczb 35 40 - - HYPH cord-329844-w969lczb 35 41 glycero glycero NNP cord-329844-w969lczb 35 42 - - HYPH cord-329844-w969lczb 35 43 L L NNP cord-329844-w969lczb 35 44 - - HYPH cord-329844-w969lczb 35 45 manno manno NNP cord-329844-w969lczb 35 46 - - HYPH cord-329844-w969lczb 35 47 nonulosonic nonulosonic NNP cord-329844-w969lczb 35 48 acid acid NN cord-329844-w969lczb 35 49 . . . cord-329844-w969lczb 36 1 If if IN cord-329844-w969lczb 36 2 the the DT cord-329844-w969lczb 36 3 term term NN cord-329844-w969lczb 36 4 " " `` cord-329844-w969lczb 36 5 sialic sialic JJ cord-329844-w969lczb 36 6 acid acid NN cord-329844-w969lczb 36 7 " " '' cord-329844-w969lczb 36 8 is be VBZ cord-329844-w969lczb 36 9 used use VBN cord-329844-w969lczb 36 10 unqualified unqualified JJ cord-329844-w969lczb 36 11 , , , cord-329844-w969lczb 36 12 it -PRON- PRP cord-329844-w969lczb 36 13 usually usually RB cord-329844-w969lczb 36 14 refers refer VBZ cord-329844-w969lczb 36 15 to to IN cord-329844-w969lczb 36 16 the the DT cord-329844-w969lczb 36 17 representative representative JJ cord-329844-w969lczb 36 18 member member NN cord-329844-w969lczb 36 19 of of IN cord-329844-w969lczb 36 20 this this DT cord-329844-w969lczb 36 21 group group NN cord-329844-w969lczb 36 22 , , , cord-329844-w969lczb 36 23 N N NNP cord-329844-w969lczb 36 24 - - HYPH cord-329844-w969lczb 36 25 acetylneuraminic acetylneuraminic NNP cord-329844-w969lczb 36 26 acid acid NN cord-329844-w969lczb 36 27 . . . cord-329844-w969lczb 37 1 The the DT cord-329844-w969lczb 37 2 variability variability NN cord-329844-w969lczb 37 3 of of IN cord-329844-w969lczb 37 4 glycans glycan NNS cord-329844-w969lczb 37 5 is be VBZ cord-329844-w969lczb 37 6 not not RB cord-329844-w969lczb 37 7 random random JJ cord-329844-w969lczb 37 8 but but CC cord-329844-w969lczb 37 9 reflects reflect VBZ cord-329844-w969lczb 37 10 their -PRON- PRP$ cord-329844-w969lczb 37 11 modes mode NNS cord-329844-w969lczb 37 12 of of IN cord-329844-w969lczb 37 13 synthesis synthesis NN cord-329844-w969lczb 37 14 . . . cord-329844-w969lczb 38 1 In in IN cord-329844-w969lczb 38 2 eukaryotes eukaryote NNS cord-329844-w969lczb 38 3 generally generally RB cord-329844-w969lczb 38 4 , , , cord-329844-w969lczb 38 5 a a DT cord-329844-w969lczb 38 6 typical typical JJ cord-329844-w969lczb 38 7 N n NN cord-329844-w969lczb 38 8 - - HYPH cord-329844-w969lczb 38 9 linked link VBN cord-329844-w969lczb 38 10 glycan glycan NN cord-329844-w969lczb 38 11 has have VBZ cord-329844-w969lczb 38 12 an an DT cord-329844-w969lczb 38 13 initial initial JJ cord-329844-w969lczb 38 14 core core NN cord-329844-w969lczb 38 15 that that WDT cord-329844-w969lczb 38 16 consists consist VBZ cord-329844-w969lczb 38 17 of of IN cord-329844-w969lczb 38 18 14 14 CD cord-329844-w969lczb 38 19 residues residue NNS cord-329844-w969lczb 38 20 ( ( -LRB- cord-329844-w969lczb 38 21 3 3 CD cord-329844-w969lczb 38 22 glucose glucose NN cord-329844-w969lczb 38 23 , , , cord-329844-w969lczb 38 24 9 9 CD cord-329844-w969lczb 38 25 mannose mannose NN cord-329844-w969lczb 38 26 , , , cord-329844-w969lczb 38 27 and and CC cord-329844-w969lczb 38 28 2 2 CD cord-329844-w969lczb 38 29 N n CD cord-329844-w969lczb 38 30 - - HYPH cord-329844-w969lczb 38 31 acetylglucosamine acetylglucosamine NNP cord-329844-w969lczb 38 32 ) ) -RRB- cord-329844-w969lczb 38 33 . . . cord-329844-w969lczb 39 1 This this DT cord-329844-w969lczb 39 2 preassembled preassembled JJ cord-329844-w969lczb 39 3 glycan glycan NN cord-329844-w969lczb 39 4 is be VBZ cord-329844-w969lczb 39 5 usually usually RB cord-329844-w969lczb 39 6 transferred transfer VBN cord-329844-w969lczb 39 7 by by IN cord-329844-w969lczb 39 8 a a DT cord-329844-w969lczb 39 9 glycosyltransferase glycosyltransferase NN cord-329844-w969lczb 39 10 oligosaccharyltransferase oligosaccharyltransferase NN cord-329844-w969lczb 39 11 to to IN cord-329844-w969lczb 39 12 a a DT cord-329844-w969lczb 39 13 nascent nascent JJ cord-329844-w969lczb 39 14 peptide peptide NN cord-329844-w969lczb 39 15 chain chain NN cord-329844-w969lczb 39 16 within within IN cord-329844-w969lczb 39 17 the the DT cord-329844-w969lczb 39 18 reticular reticular JJ cord-329844-w969lczb 39 19 lumen lumen NN cord-329844-w969lczb 39 20 . . . cord-329844-w969lczb 40 1 This this DT cord-329844-w969lczb 40 2 initial initial JJ cord-329844-w969lczb 40 3 core core NN cord-329844-w969lczb 40 4 14-sugar 14-sugar CD cord-329844-w969lczb 40 5 unit unit NN cord-329844-w969lczb 40 6 is be VBZ cord-329844-w969lczb 40 7 assembled assemble VBN cord-329844-w969lczb 40 8 in in IN cord-329844-w969lczb 40 9 the the DT cord-329844-w969lczb 40 10 cytoplasm cytoplasm NN cord-329844-w969lczb 40 11 and and CC cord-329844-w969lczb 40 12 endoplasmic endoplasmic NN cord-329844-w969lczb 40 13 reticulum reticulum NN cord-329844-w969lczb 40 14 and and CC cord-329844-w969lczb 40 15 other other JJ cord-329844-w969lczb 40 16 sugars sugar NNS cord-329844-w969lczb 40 17 may may MD cord-329844-w969lczb 40 18 be be VB cord-329844-w969lczb 40 19 added add VBN cord-329844-w969lczb 40 20 later later RB cord-329844-w969lczb 40 21 . . . cord-329844-w969lczb 41 1 In in IN cord-329844-w969lczb 41 2 contrast contrast NN cord-329844-w969lczb 41 3 , , , cord-329844-w969lczb 41 4 O o NN cord-329844-w969lczb 41 5 - - HYPH cord-329844-w969lczb 41 6 linked link VBN cord-329844-w969lczb 41 7 glycans glycan NNS cord-329844-w969lczb 41 8 are be VBP cord-329844-w969lczb 41 9 assembled assemble VBN cord-329844-w969lczb 41 10 one one CD cord-329844-w969lczb 41 11 sugar sugar NN cord-329844-w969lczb 41 12 at at IN cord-329844-w969lczb 41 13 a a DT cord-329844-w969lczb 41 14 time time NN cord-329844-w969lczb 41 15 at at IN cord-329844-w969lczb 41 16 the the DT cord-329844-w969lczb 41 17 outset outset NN cord-329844-w969lczb 41 18 on on IN cord-329844-w969lczb 41 19 proteins protein NNS cord-329844-w969lczb 41 20 in in IN cord-329844-w969lczb 41 21 the the DT cord-329844-w969lczb 41 22 Golgi Golgi NNP cord-329844-w969lczb 41 23 apparatus apparatus NN cord-329844-w969lczb 41 24 . . . cord-329844-w969lczb 42 1 There there EX cord-329844-w969lczb 42 2 are be VBP cord-329844-w969lczb 42 3 some some DT cord-329844-w969lczb 42 4 specific specific JJ cord-329844-w969lczb 42 5 features feature NNS cord-329844-w969lczb 42 6 of of IN cord-329844-w969lczb 42 7 medical medical JJ cord-329844-w969lczb 42 8 interest interest NN cord-329844-w969lczb 42 9 as as IN cord-329844-w969lczb 42 10 relevant relevant JJ cord-329844-w969lczb 42 11 to to IN cord-329844-w969lczb 42 12 the the DT cord-329844-w969lczb 42 13 human human JJ cord-329844-w969lczb 42 14 host host NN cord-329844-w969lczb 42 15 of of IN cord-329844-w969lczb 42 16 viruses virus NNS cord-329844-w969lczb 42 17 ( ( -LRB- cord-329844-w969lczb 42 18 but but CC cord-329844-w969lczb 42 19 by by IN cord-329844-w969lczb 42 20 no no DT cord-329844-w969lczb 42 21 means means NN cord-329844-w969lczb 42 22 unique unique JJ cord-329844-w969lczb 42 23 to to IN cord-329844-w969lczb 42 24 humans human NNS cord-329844-w969lczb 42 25 ) ) -RRB- cord-329844-w969lczb 42 26 . . . cord-329844-w969lczb 43 1 The the DT cord-329844-w969lczb 43 2 lung lung NN cord-329844-w969lczb 43 3 epithelial epithelial JJ cord-329844-w969lczb 43 4 glycans glycan NNS cord-329844-w969lczb 43 5 are be VBP cord-329844-w969lczb 43 6 typical typical JJ cord-329844-w969lczb 43 7 by by IN cord-329844-w969lczb 43 8 having have VBG cord-329844-w969lczb 43 9 sialic sialic JJ cord-329844-w969lczb 43 10 acids acid NNS cord-329844-w969lczb 43 11 as as IN cord-329844-w969lczb 43 12 the the DT cord-329844-w969lczb 43 13 distal distal JJ cord-329844-w969lczb 43 14 residues residue NNS cord-329844-w969lczb 43 15 , , , cord-329844-w969lczb 43 16 and and CC cord-329844-w969lczb 43 17 it -PRON- PRP cord-329844-w969lczb 43 18 is be VBZ cord-329844-w969lczb 43 19 these these DT cord-329844-w969lczb 43 20 that that IN cord-329844-w969lczb 43 21 the the DT cord-329844-w969lczb 43 22 influenza influenza NN cord-329844-w969lczb 43 23 neuraminidase neuraminidase NN cord-329844-w969lczb 43 24 cleaves cleave VBZ cord-329844-w969lczb 43 25 away away RB cord-329844-w969lczb 43 26 . . . cord-329844-w969lczb 44 1 Most most RBS cord-329844-w969lczb 44 2 soluble soluble JJ cord-329844-w969lczb 44 3 secreted secrete VBN cord-329844-w969lczb 44 4 proteins protein NNS cord-329844-w969lczb 44 5 are be VBP cord-329844-w969lczb 44 6 also also RB cord-329844-w969lczb 44 7 similarly similarly RB cord-329844-w969lczb 44 8 decorated decorate VBN cord-329844-w969lczb 44 9 with with IN cord-329844-w969lczb 44 10 such such JJ cord-329844-w969lczb 44 11 glycans glycan NNS cord-329844-w969lczb 44 12 . . . cord-329844-w969lczb 45 1 That that DT cord-329844-w969lczb 45 2 includes include VBZ cord-329844-w969lczb 45 3 the the DT cord-329844-w969lczb 45 4 proteins protein NNS cord-329844-w969lczb 45 5 that that WDT cord-329844-w969lczb 45 6 make make VBP cord-329844-w969lczb 45 7 up up RP cord-329844-w969lczb 45 8 saliva saliva NN cord-329844-w969lczb 45 9 and and CC cord-329844-w969lczb 45 10 mucus mucus NN cord-329844-w969lczb 45 11 in in IN cord-329844-w969lczb 45 12 the the DT cord-329844-w969lczb 45 13 airway airway NN cord-329844-w969lczb 45 14 , , , cord-329844-w969lczb 45 15 and and CC cord-329844-w969lczb 45 16 are be VBP cord-329844-w969lczb 45 17 in in IN cord-329844-w969lczb 45 18 general general JJ cord-329844-w969lczb 45 19 important important JJ cord-329844-w969lczb 45 20 for for IN cord-329844-w969lczb 45 21 viral viral JJ cord-329844-w969lczb 45 22 infection infection NN cord-329844-w969lczb 45 23 . . . cord-329844-w969lczb 46 1 Both both DT cord-329844-w969lczb 46 2 N N NNP cord-329844-w969lczb 46 3 - - : cord-329844-w969lczb 46 4 and and CC cord-329844-w969lczb 46 5 O O NNP cord-329844-w969lczb 46 6 - - HYPH cord-329844-w969lczb 46 7 and and CC cord-329844-w969lczb 46 8 glycosphingolipid glycosphingolipid NN cord-329844-w969lczb 46 9 - - HYPH cord-329844-w969lczb 46 10 glycans glycan NNS cord-329844-w969lczb 46 11 are be VBP cord-329844-w969lczb 46 12 found find VBN cord-329844-w969lczb 46 13 in in IN cord-329844-w969lczb 46 14 human human JJ cord-329844-w969lczb 46 15 lungs lung NNS cord-329844-w969lczb 46 16 , , , cord-329844-w969lczb 46 17 and and CC cord-329844-w969lczb 46 18 they -PRON- PRP cord-329844-w969lczb 46 19 include include VBP cord-329844-w969lczb 46 20 large large JJ cord-329844-w969lczb 46 21 and and CC cord-329844-w969lczb 46 22 complex complex JJ cord-329844-w969lczb 46 23 - - HYPH cord-329844-w969lczb 46 24 type type NN cord-329844-w969lczb 46 25 N n NN cord-329844-w969lczb 46 26 - - HYPH cord-329844-w969lczb 46 27 glycans glycan NNS cord-329844-w969lczb 46 28 with with IN cord-329844-w969lczb 46 29 linear linear JJ cord-329844-w969lczb 46 30 poly poly NNP cord-329844-w969lczb 46 31 - - HYPH cord-329844-w969lczb 46 32 N N NNP cord-329844-w969lczb 46 33 - - HYPH cord-329844-w969lczb 46 34 acetyllactosamine acetyllactosamine NN cord-329844-w969lczb 46 35 [ [ -LRB- cord-329844-w969lczb 46 36 -3Galβ1 -3Galβ1 NNP cord-329844-w969lczb 46 37 - - HYPH cord-329844-w969lczb 46 38 4GlcNAcβ1- 4GlcNAcβ1- NNP cord-329844-w969lczb 46 39 ] ] -RRB- cord-329844-w969lczb 46 40 n n CC cord-329844-w969lczb 46 41 extensions extension NNS cord-329844-w969lczb 46 42 , , , cord-329844-w969lczb 46 43 which which WDT cord-329844-w969lczb 46 44 are be VBP cord-329844-w969lczb 46 45 predominantly predominantly RB cord-329844-w969lczb 46 46 terminated terminate VBN cord-329844-w969lczb 46 47 in in IN cord-329844-w969lczb 46 48 α2,3-linked α2,3-linked CD cord-329844-w969lczb 46 49 sialic sialic JJ cord-329844-w969lczb 46 50 acid acid NN cord-329844-w969lczb 46 51 . . . cord-329844-w969lczb 47 1 In in IN cord-329844-w969lczb 47 2 contrast contrast NN cord-329844-w969lczb 47 3 , , , cord-329844-w969lczb 47 4 the the DT cord-329844-w969lczb 47 5 smaller small JJR cord-329844-w969lczb 47 6 N n CD cord-329844-w969lczb 47 7 - - HYPH cord-329844-w969lczb 47 8 glycans glycan NNS cord-329844-w969lczb 47 9 lack lack VBP cord-329844-w969lczb 47 10 poly poly JJ cord-329844-w969lczb 47 11 - - HYPH cord-329844-w969lczb 47 12 N n NN cord-329844-w969lczb 47 13 - - HYPH cord-329844-w969lczb 47 14 acetyllactosamine acetyllactosamine NNP cord-329844-w969lczb 47 15 but but CC cord-329844-w969lczb 47 16 are be VBP cord-329844-w969lczb 47 17 enriched enrich VBN cord-329844-w969lczb 47 18 in in IN cord-329844-w969lczb 47 19 α2,6-linked α2,6-linked CD cord-329844-w969lczb 47 20 sialic sialic JJ cord-329844-w969lczb 47 21 acids acid NNS cord-329844-w969lczb 47 22 . . . cord-329844-w969lczb 48 1 There there EX cord-329844-w969lczb 48 2 are be VBP cord-329844-w969lczb 48 3 also also RB cord-329844-w969lczb 48 4 large large JJ cord-329844-w969lczb 48 5 glycosphingolipid glycosphingolipid NN cord-329844-w969lczb 48 6 glycans glycan NNS cord-329844-w969lczb 48 7 , , , cord-329844-w969lczb 48 8 which which WDT cord-329844-w969lczb 48 9 also also RB cord-329844-w969lczb 48 10 consists consist VBZ cord-329844-w969lczb 48 11 of of IN cord-329844-w969lczb 48 12 poly poly NNP cord-329844-w969lczb 48 13 - - HYPH cord-329844-w969lczb 48 14 N N NNP cord-329844-w969lczb 48 15 - - HYPH cord-329844-w969lczb 48 16 acetyllactosamine acetyllactosamine NNP cord-329844-w969lczb 48 17 , , , cord-329844-w969lczb 48 18 usually usually RB cord-329844-w969lczb 48 19 terminating terminate VBG cord-329844-w969lczb 48 20 in in IN cord-329844-w969lczb 48 21 α2,3-linked α2,3-linked CD cord-329844-w969lczb 48 22 sialic sialic JJ cord-329844-w969lczb 48 23 acid acid NN cord-329844-w969lczb 48 24 . . . cord-329844-w969lczb 49 1 While while IN cord-329844-w969lczb 49 2 it -PRON- PRP cord-329844-w969lczb 49 3 is be VBZ cord-329844-w969lczb 49 4 commonly commonly RB cord-329844-w969lczb 49 5 maintained maintain VBN cord-329844-w969lczb 49 6 that that IN cord-329844-w969lczb 49 7 viruses virus NNS cord-329844-w969lczb 49 8 such such JJ cord-329844-w969lczb 49 9 as as IN cord-329844-w969lczb 49 10 influenza influenza NN cord-329844-w969lczb 49 11 virus virus NN cord-329844-w969lczb 49 12 bind bind NN cord-329844-w969lczb 49 13 to to IN cord-329844-w969lczb 49 14 the the DT cord-329844-w969lczb 49 15 sialylated sialylate VBN cord-329844-w969lczb 49 16 glycans glycan NNS cord-329844-w969lczb 49 17 , , , cord-329844-w969lczb 49 18 and and CC cord-329844-w969lczb 49 19 this this DT cord-329844-w969lczb 49 20 is be VBZ cord-329844-w969lczb 49 21 assumed assume VBN cord-329844-w969lczb 49 22 in in IN cord-329844-w969lczb 49 23 the the DT cord-329844-w969lczb 49 24 present present JJ cord-329844-w969lczb 49 25 paper paper NN cord-329844-w969lczb 49 26 , , , cord-329844-w969lczb 49 27 some some DT cord-329844-w969lczb 49 28 care care NN cord-329844-w969lczb 49 29 is be VBZ cord-329844-w969lczb 49 30 required require VBN cord-329844-w969lczb 49 31 , , , cord-329844-w969lczb 49 32 because because IN cord-329844-w969lczb 49 33 there there EX cord-329844-w969lczb 49 34 are be VBP cord-329844-w969lczb 49 35 also also RB cord-329844-w969lczb 49 36 nonsialylated nonsialylate VBN cord-329844-w969lczb 49 37 glycans glycan NNS cord-329844-w969lczb 49 38 in in IN cord-329844-w969lczb 49 39 human human JJ cord-329844-w969lczb 49 40 lungs lung NNS cord-329844-w969lczb 49 41 on on IN cord-329844-w969lczb 49 42 which which WDT cord-329844-w969lczb 49 43 viral viral JJ cord-329844-w969lczb 49 44 binding binding NN cord-329844-w969lczb 49 45 could could MD cord-329844-w969lczb 49 46 occur occur VB cord-329844-w969lczb 49 47 . . . cord-329844-w969lczb 50 1 While while IN cord-329844-w969lczb 50 2 it -PRON- PRP cord-329844-w969lczb 50 3 is be VBZ cord-329844-w969lczb 50 4 binding bind VBG cord-329844-w969lczb 50 5 of of IN cord-329844-w969lczb 50 6 viruses virus NNS cord-329844-w969lczb 50 7 to to IN cord-329844-w969lczb 50 8 sialic sialic JJ cord-329844-w969lczb 50 9 acid acid NN cord-329844-w969lczb 50 10 glycan glycan NN cord-329844-w969lczb 50 11 that that WDT cord-329844-w969lczb 50 12 is be VBZ cord-329844-w969lczb 50 13 of of IN cord-329844-w969lczb 50 14 interest interest NN cord-329844-w969lczb 50 15 here here RB cord-329844-w969lczb 50 16 , , , cord-329844-w969lczb 50 17 it -PRON- PRP cord-329844-w969lczb 50 18 should should MD cord-329844-w969lczb 50 19 be be VB cord-329844-w969lczb 50 20 kept keep VBN cord-329844-w969lczb 50 21 in in IN cord-329844-w969lczb 50 22 mind mind NN cord-329844-w969lczb 50 23 that that IN cord-329844-w969lczb 50 24 it -PRON- PRP cord-329844-w969lczb 50 25 is be VBZ cord-329844-w969lczb 50 26 often often RB cord-329844-w969lczb 50 27 associated associate VBN cord-329844-w969lczb 50 28 with with IN cord-329844-w969lczb 50 29 a a DT cord-329844-w969lczb 50 30 catalytic catalytic JJ cord-329844-w969lczb 50 31 activity activity NN cord-329844-w969lczb 50 32 in in IN cord-329844-w969lczb 50 33 which which WDT cord-329844-w969lczb 50 34 the the DT cord-329844-w969lczb 50 35 sialic sialic JJ cord-329844-w969lczb 50 36 acid acid NN cord-329844-w969lczb 50 37 glycan glycan NN cord-329844-w969lczb 50 38 is be VBZ cord-329844-w969lczb 50 39 the the DT cord-329844-w969lczb 50 40 substrate substrate NN cord-329844-w969lczb 50 41 . . . cord-329844-w969lczb 51 1 In in IN cord-329844-w969lczb 51 2 influenza influenza NN cord-329844-w969lczb 51 3 these these DT cord-329844-w969lczb 51 4 two two CD cord-329844-w969lczb 51 5 aspects aspect NNS cord-329844-w969lczb 51 6 are be VBP cord-329844-w969lczb 51 7 particularly particularly RB cord-329844-w969lczb 51 8 distinct distinct JJ cord-329844-w969lczb 51 9 by by IN cord-329844-w969lczb 51 10 being be VBG cord-329844-w969lczb 51 11 on on IN cord-329844-w969lczb 51 12 separate separate JJ cord-329844-w969lczb 51 13 surface surface NN cord-329844-w969lczb 51 14 proteins protein NNS cord-329844-w969lczb 51 15 , , , cord-329844-w969lczb 51 16 the the DT cord-329844-w969lczb 51 17 hemagglutinin hemagglutinin NN cord-329844-w969lczb 51 18 and and CC cord-329844-w969lczb 51 19 neuraminidase neuraminidase NN cord-329844-w969lczb 51 20 respectively respectively RB cord-329844-w969lczb 51 21 , , , cord-329844-w969lczb 51 22 but but CC cord-329844-w969lczb 51 23 that that DT cord-329844-w969lczb 51 24 separation separation NN cord-329844-w969lczb 51 25 is be VBZ cord-329844-w969lczb 51 26 not not RB cord-329844-w969lczb 51 27 true true JJ cord-329844-w969lczb 51 28 of of IN cord-329844-w969lczb 51 29 all all DT cord-329844-w969lczb 51 30 viruses virus NNS cord-329844-w969lczb 51 31 . . . cord-329844-w969lczb 52 1 Not not RB cord-329844-w969lczb 52 2 surprisingly surprisingly RB cord-329844-w969lczb 52 3 , , , cord-329844-w969lczb 52 4 as as IN cord-329844-w969lczb 52 5 noted note VBN cord-329844-w969lczb 52 6 above above RB cord-329844-w969lczb 52 7 , , , cord-329844-w969lczb 52 8 most most JJS cord-329844-w969lczb 52 9 coronaviruses coronaviruse NNS cord-329844-w969lczb 52 10 of of IN cord-329844-w969lczb 52 11 the the DT cord-329844-w969lczb 52 12 coronaviridae coronaviridae NNP cord-329844-w969lczb 52 13 family family NN cord-329844-w969lczb 52 14 also also RB cord-329844-w969lczb 52 15 have have VBP cord-329844-w969lczb 52 16 capabilities capability NNS cord-329844-w969lczb 52 17 to to TO cord-329844-w969lczb 52 18 bind bind VB cord-329844-w969lczb 52 19 to to IN cord-329844-w969lczb 52 20 sialic sialic JJ cord-329844-w969lczb 52 21 acid acid NN cord-329844-w969lczb 52 22 glycans glycan NNS cord-329844-w969lczb 52 23 , , , cord-329844-w969lczb 52 24 but but CC cord-329844-w969lczb 52 25 they -PRON- PRP cord-329844-w969lczb 52 26 also also RB cord-329844-w969lczb 52 27 have have VBP cord-329844-w969lczb 52 28 the the DT cord-329844-w969lczb 52 29 ability ability NN cord-329844-w969lczb 52 30 to to TO cord-329844-w969lczb 52 31 cleave cleave VB cord-329844-w969lczb 52 32 the the DT cord-329844-w969lczb 52 33 glycans glycan NNS cord-329844-w969lczb 52 34 , , , cord-329844-w969lczb 52 35 which which WDT cord-329844-w969lczb 52 36 is be VBZ cord-329844-w969lczb 52 37 often often RB cord-329844-w969lczb 52 38 described describe VBN cord-329844-w969lczb 52 39 by by IN cord-329844-w969lczb 52 40 authors author NNS cord-329844-w969lczb 52 41 as as IN cord-329844-w969lczb 52 42 a a DT cord-329844-w969lczb 52 43 " " `` cord-329844-w969lczb 52 44 receptor receptor NN cord-329844-w969lczb 52 45 destroying destroy VBG cord-329844-w969lczb 52 46 activity activity NN cord-329844-w969lczb 52 47 " " '' cord-329844-w969lczb 52 48 . . . cord-329844-w969lczb 53 1 Like like IN cord-329844-w969lczb 53 2 influenza influenza NN cord-329844-w969lczb 53 3 C c NN cord-329844-w969lczb 53 4 viruses virus NNS cord-329844-w969lczb 53 5 , , , cord-329844-w969lczb 53 6 purified purify VBN cord-329844-w969lczb 53 7 bovine bovine JJ cord-329844-w969lczb 53 8 coronavirus coronavirus NN cord-329844-w969lczb 53 9 preparations preparation NNS cord-329844-w969lczb 53 10 have have VBP cord-329844-w969lczb 53 11 an an DT cord-329844-w969lczb 53 12 esterase esterase NN cord-329844-w969lczb 53 13 activity activity NN cord-329844-w969lczb 53 14 which which WDT cord-329844-w969lczb 53 15 inactivates inactivate VBZ cord-329844-w969lczb 53 16 O o NN cord-329844-w969lczb 53 17 - - HYPH cord-329844-w969lczb 53 18 acetylsialic acetylsialic JJ cord-329844-w969lczb 53 19 acidcontaining acidcontaining NN cord-329844-w969lczb 53 20 receptors receptor NNS cord-329844-w969lczb 53 21 on on IN cord-329844-w969lczb 53 22 erythrocytes erythrocyte NNS cord-329844-w969lczb 53 23 ; ; : cord-329844-w969lczb 53 24 diisopropyl diisopropyl NNP cord-329844-w969lczb 53 25 fluorophosphate fluorophosphate NNP cord-329844-w969lczb 53 26 completely completely RB cord-329844-w969lczb 53 27 inhibited inhibit VBN cord-329844-w969lczb 53 28 this this DT cord-329844-w969lczb 53 29 receptor receptor NN cord-329844-w969lczb 53 30 - - HYPH cord-329844-w969lczb 53 31 destroying destroy VBG cord-329844-w969lczb 53 32 activity activity NN cord-329844-w969lczb 53 33 suggesting suggest VBG cord-329844-w969lczb 53 34 that that IN cord-329844-w969lczb 53 35 the the DT cord-329844-w969lczb 53 36 viral viral JJ cord-329844-w969lczb 53 37 enzyme enzyme NN cord-329844-w969lczb 53 38 is be VBZ cord-329844-w969lczb 53 39 in in IN cord-329844-w969lczb 53 40 this this DT cord-329844-w969lczb 53 41 case case NN cord-329844-w969lczb 53 42 a a DT cord-329844-w969lczb 53 43 serine serine NN cord-329844-w969lczb 53 44 esterase esterase NN cord-329844-w969lczb 53 45 [ [ -LRB- cord-329844-w969lczb 53 46 8 8 CD cord-329844-w969lczb 53 47 ] ] -RRB- cord-329844-w969lczb 53 48 . . . cord-329844-w969lczb 54 1 This this DT cord-329844-w969lczb 54 2 is be VBZ cord-329844-w969lczb 54 3 believed believe VBN cord-329844-w969lczb 54 4 to to TO cord-329844-w969lczb 54 5 facilitate facilitate VB cord-329844-w969lczb 54 6 the the DT cord-329844-w969lczb 54 7 spread spread NN cord-329844-w969lczb 54 8 of of IN cord-329844-w969lczb 54 9 virus virus NN cord-329844-w969lczb 54 10 infection infection NN cord-329844-w969lczb 54 11 by by IN cord-329844-w969lczb 54 12 removing remove VBG cord-329844-w969lczb 54 13 receptor receptor NN cord-329844-w969lczb 54 14 determinants determinant NNS cord-329844-w969lczb 54 15 from from IN cord-329844-w969lczb 54 16 the the DT cord-329844-w969lczb 54 17 surface surface NN cord-329844-w969lczb 54 18 of of IN cord-329844-w969lczb 54 19 infected infected JJ cord-329844-w969lczb 54 20 cells cell NNS cord-329844-w969lczb 54 21 ( ( -LRB- cord-329844-w969lczb 54 22 see see VB cord-329844-w969lczb 54 23 discussion discussion NN cord-329844-w969lczb 54 24 below below RB cord-329844-w969lczb 54 25 ) ) -RRB- cord-329844-w969lczb 54 26 and and CC cord-329844-w969lczb 54 27 prevent prevent VB cord-329844-w969lczb 54 28 the the DT cord-329844-w969lczb 54 29 formation formation NN cord-329844-w969lczb 54 30 of of IN cord-329844-w969lczb 54 31 virus virus NN cord-329844-w969lczb 54 32 aggregates aggregate NNS cord-329844-w969lczb 54 33 . . . cord-329844-w969lczb 55 1 Another another DT cord-329844-w969lczb 55 2 coronavirus coronavirus NN cord-329844-w969lczb 55 3 , , , cord-329844-w969lczb 55 4 porcine porcine JJ cord-329844-w969lczb 55 5 transmissible transmissible JJ cord-329844-w969lczb 55 6 gastroenteritis gastroenteritis NN cord-329844-w969lczb 55 7 virus virus NN cord-329844-w969lczb 55 8 ( ( -LRB- cord-329844-w969lczb 55 9 TGEV TGEV NNP cord-329844-w969lczb 55 10 ) ) -RRB- cord-329844-w969lczb 55 11 recognizes recognize VBZ cord-329844-w969lczb 55 12 N n CD cord-329844-w969lczb 55 13 - - HYPH cord-329844-w969lczb 55 14 glycolylneuraminic glycolylneuraminic NN cord-329844-w969lczb 55 15 acid acid NN cord-329844-w969lczb 55 16 . . . cord-329844-w969lczb 56 1 Nor nor CC cord-329844-w969lczb 56 2 does do VBZ cord-329844-w969lczb 56 3 it -PRON- PRP cord-329844-w969lczb 56 4 depend depend VB cord-329844-w969lczb 56 5 on on IN cord-329844-w969lczb 56 6 the the DT cord-329844-w969lczb 56 7 sialic sialic JJ cord-329844-w969lczb 56 8 acid acid NN cord-329844-w969lczb 56 9 binding bind VBG cord-329844-w969lczb 56 10 activity activity NN cord-329844-w969lczb 56 11 for for IN cord-329844-w969lczb 56 12 infection infection NN cord-329844-w969lczb 56 13 of of IN cord-329844-w969lczb 56 14 cultured cultured JJ cord-329844-w969lczb 56 15 cells cell NNS cord-329844-w969lczb 56 16 , , , cord-329844-w969lczb 56 17 but but CC cord-329844-w969lczb 56 18 interaction interaction NN cord-329844-w969lczb 56 19 with with IN cord-329844-w969lczb 56 20 sialoglycoconjugates sialoglycoconjugates NNP cord-329844-w969lczb 56 21 appears appear VBZ cord-329844-w969lczb 56 22 to to TO cord-329844-w969lczb 56 23 help help VB cord-329844-w969lczb 56 24 the the DT cord-329844-w969lczb 56 25 virus virus NN cord-329844-w969lczb 56 26 to to TO cord-329844-w969lczb 56 27 pass pass VB cord-329844-w969lczb 56 28 through through IN cord-329844-w969lczb 56 29 the the DT cord-329844-w969lczb 56 30 sialic sialic JJ cord-329844-w969lczb 56 31 acid acid NN cord-329844-w969lczb 56 32 - - HYPH cord-329844-w969lczb 56 33 rich rich JJ cord-329844-w969lczb 56 34 mucus mucus NN cord-329844-w969lczb 56 35 layer layer NN cord-329844-w969lczb 56 36 in in IN cord-329844-w969lczb 56 37 the the DT cord-329844-w969lczb 56 38 epithelium epithelium NN cord-329844-w969lczb 56 39 of of IN cord-329844-w969lczb 56 40 the the DT cord-329844-w969lczb 56 41 small small JJ cord-329844-w969lczb 56 42 intestine intestine NN cord-329844-w969lczb 56 43 . . . cord-329844-w969lczb 57 1 Hemagglutinin Hemagglutinin NNP cord-329844-w969lczb 57 2 - - HYPH cord-329844-w969lczb 57 3 esterases esterases NNP cord-329844-w969lczb 57 4 are be VBP cord-329844-w969lczb 57 5 a a DT cord-329844-w969lczb 57 6 family family NN cord-329844-w969lczb 57 7 of of IN cord-329844-w969lczb 57 8 viral viral JJ cord-329844-w969lczb 57 9 envelope envelope NN cord-329844-w969lczb 57 10 glycoproteins glycoprotein NNS cord-329844-w969lczb 57 11 that that WDT cord-329844-w969lczb 57 12 mediate mediate VBP cord-329844-w969lczb 57 13 reversible reversible JJ cord-329844-w969lczb 57 14 attachment attachment NN cord-329844-w969lczb 57 15 to to IN cord-329844-w969lczb 57 16 Oacetylated oacetylated JJ cord-329844-w969lczb 57 17 sialic sialic JJ cord-329844-w969lczb 57 18 acids acid NNS cord-329844-w969lczb 57 19 . . . cord-329844-w969lczb 58 1 These these DT cord-329844-w969lczb 58 2 too too RB cord-329844-w969lczb 58 3 are be VBP cord-329844-w969lczb 58 4 said say VBN cord-329844-w969lczb 58 5 to to TO cord-329844-w969lczb 58 6 be be VB cord-329844-w969lczb 58 7 receptor receptor NN cord-329844-w969lczb 58 8 - - HYPH cord-329844-w969lczb 58 9 destroying destroy VBG cord-329844-w969lczb 58 10 , , , cord-329844-w969lczb 58 11 but but CC cord-329844-w969lczb 58 12 the the DT cord-329844-w969lczb 58 13 enzymic enzymic NNP cord-329844-w969lczb 58 14 activity activity NN cord-329844-w969lczb 58 15 reaction reaction NN cord-329844-w969lczb 58 16 is be VBZ cord-329844-w969lczb 58 17 in in IN cord-329844-w969lczb 58 18 this this DT cord-329844-w969lczb 58 19 case case NN cord-329844-w969lczb 58 20 not not RB cord-329844-w969lczb 58 21 a a DT cord-329844-w969lczb 58 22 cleavage cleavage NN cord-329844-w969lczb 58 23 in in IN cord-329844-w969lczb 58 24 the the DT cord-329844-w969lczb 58 25 sense sense NN cord-329844-w969lczb 58 26 used use VBD cord-329844-w969lczb 58 27 concerning concern VBG cord-329844-w969lczb 58 28 neuraminidase neuraminidase NN cord-329844-w969lczb 58 29 , , , cord-329844-w969lczb 58 30 but but CC cord-329844-w969lczb 58 31 rather rather RB cord-329844-w969lczb 58 32 a a DT cord-329844-w969lczb 58 33 change change NN cord-329844-w969lczb 58 34 in in IN cord-329844-w969lczb 58 35 molecular molecular JJ cord-329844-w969lczb 58 36 recognition recognition NN cord-329844-w969lczb 58 37 by by IN cord-329844-w969lczb 58 38 removal removal NN cord-329844-w969lczb 58 39 from from IN cord-329844-w969lczb 58 40 of of IN cord-329844-w969lczb 58 41 the the DT cord-329844-w969lczb 58 42 acetyl acetyl NNP cord-329844-w969lczb 58 43 group group NN cord-329844-w969lczb 58 44 from from IN cord-329844-w969lczb 58 45 the the DT cord-329844-w969lczb 58 46 C9 C9 NNP cord-329844-w969lczb 58 47 position position NN cord-329844-w969lczb 58 48 of of IN cord-329844-w969lczb 58 49 the the DT cord-329844-w969lczb 58 50 above above JJ cord-329844-w969lczb 58 51 acetylated acetylated JJ cord-329844-w969lczb 58 52 neuraminic neuraminic JJ cord-329844-w969lczb 58 53 acid acid NN cord-329844-w969lczb 58 54 residues residue NNS cord-329844-w969lczb 58 55 . . . cord-329844-w969lczb 59 1 The the DT cord-329844-w969lczb 59 2 other other JJ cord-329844-w969lczb 59 3 and and CC cord-329844-w969lczb 59 4 probably probably RB cord-329844-w969lczb 59 5 major major JJ cord-329844-w969lczb 59 6 reason reason NN cord-329844-w969lczb 59 7 for for IN cord-329844-w969lczb 59 8 researchers researcher NNS cord-329844-w969lczb 59 9 thinking think VBG cord-329844-w969lczb 59 10 of of IN cord-329844-w969lczb 59 11 these these DT cord-329844-w969lczb 59 12 actions action NNS cord-329844-w969lczb 59 13 as as IN cord-329844-w969lczb 59 14 " " `` cord-329844-w969lczb 59 15 receptor receptor NN cord-329844-w969lczb 59 16 destroying destroy VBG cord-329844-w969lczb 59 17 " " '' cord-329844-w969lczb 59 18 is be VBZ cord-329844-w969lczb 59 19 because because IN cord-329844-w969lczb 59 20 the the DT cord-329844-w969lczb 59 21 picture picture NN cord-329844-w969lczb 59 22 is be VBZ cord-329844-w969lczb 59 23 a a DT cord-329844-w969lczb 59 24 little little JJ cord-329844-w969lczb 59 25 more more RBR cord-329844-w969lczb 59 26 complex complex JJ cord-329844-w969lczb 59 27 than than IN cord-329844-w969lczb 59 28 just just RB cord-329844-w969lczb 59 29 allowing allow VBG cord-329844-w969lczb 59 30 entry entry NN cord-329844-w969lczb 59 31 and and CC cord-329844-w969lczb 59 32 exit exit NN cord-329844-w969lczb 59 33 from from IN cord-329844-w969lczb 59 34 the the DT cord-329844-w969lczb 59 35 host host NN cord-329844-w969lczb 59 36 cell cell NN cord-329844-w969lczb 59 37 . . . cord-329844-w969lczb 60 1 Because because IN cord-329844-w969lczb 60 2 many many JJ cord-329844-w969lczb 60 3 viruses virus NNS cord-329844-w969lczb 60 4 attain attain VBP cord-329844-w969lczb 60 5 host host NN cord-329844-w969lczb 60 6 cell cell NN cord-329844-w969lczb 60 7 specificity specificity NN cord-329844-w969lczb 60 8 by by IN cord-329844-w969lczb 60 9 being be VBG cord-329844-w969lczb 60 10 selective selective JJ cord-329844-w969lczb 60 11 for for IN cord-329844-w969lczb 60 12 particular particular JJ cord-329844-w969lczb 60 13 types type NNS cord-329844-w969lczb 60 14 of of IN cord-329844-w969lczb 60 15 sialic sialic JJ cord-329844-w969lczb 60 16 acid acid NN cord-329844-w969lczb 60 17 , , , cord-329844-w969lczb 60 18 these these DT cord-329844-w969lczb 60 19 may may MD cord-329844-w969lczb 60 20 occur occur VB cord-329844-w969lczb 60 21 as as IN cord-329844-w969lczb 60 22 decoys decoy NNS cord-329844-w969lczb 60 23 to to IN cord-329844-w969lczb 60 24 the the DT cord-329844-w969lczb 60 25 virus virus NN cord-329844-w969lczb 60 26 on on IN cord-329844-w969lczb 60 27 off off IN cord-329844-w969lczb 60 28 - - HYPH cord-329844-w969lczb 60 29 target target NN cord-329844-w969lczb 60 30 host host NN cord-329844-w969lczb 60 31 cells cell NNS cord-329844-w969lczb 60 32 and and CC cord-329844-w969lczb 60 33 on on IN cord-329844-w969lczb 60 34 free free JJ cord-329844-w969lczb 60 35 molecules molecule NNS cord-329844-w969lczb 60 36 in in IN cord-329844-w969lczb 60 37 the the DT cord-329844-w969lczb 60 38 extracellular extracellular JJ cord-329844-w969lczb 60 39 environment environment NN cord-329844-w969lczb 60 40 . . . cord-329844-w969lczb 61 1 To to TO cord-329844-w969lczb 61 2 prevent prevent VB cord-329844-w969lczb 61 3 irreversible irreversible JJ cord-329844-w969lczb 61 4 binding binding NN cord-329844-w969lczb 61 5 to to IN cord-329844-w969lczb 61 6 these these DT cord-329844-w969lczb 61 7 decoys decoy NNS cord-329844-w969lczb 61 8 , , , cord-329844-w969lczb 61 9 many many JJ cord-329844-w969lczb 61 10 viruses virus NNS cord-329844-w969lczb 61 11 including include VBG cord-329844-w969lczb 61 12 many many JJ cord-329844-w969lczb 61 13 coronaviruses coronaviruse NNS cord-329844-w969lczb 61 14 have have VBP cord-329844-w969lczb 61 15 receptor receptor NN cord-329844-w969lczb 61 16 - - HYPH cord-329844-w969lczb 61 17 destroying destroy VBG cord-329844-w969lczb 61 18 enzymes enzyme NNS cord-329844-w969lczb 61 19 that that WDT cord-329844-w969lczb 61 20 are be VBP cord-329844-w969lczb 61 21 therefore therefore RB cord-329844-w969lczb 61 22 interesting interesting JJ cord-329844-w969lczb 61 23 targets target NNS cord-329844-w969lczb 61 24 for for IN cord-329844-w969lczb 61 25 antiviral antiviral JJ cord-329844-w969lczb 61 26 intervention intervention NN cord-329844-w969lczb 61 27 , , , cord-329844-w969lczb 61 28 exemplified exemplify VBN cord-329844-w969lczb 61 29 by by IN cord-329844-w969lczb 61 30 the the DT cord-329844-w969lczb 61 31 influenza influenza NN cord-329844-w969lczb 61 32 A a DT cord-329844-w969lczb 61 33 virus virus NN cord-329844-w969lczb 61 34 neuraminidase neuraminidase NN cord-329844-w969lczb 61 35 [ [ -LRB- cord-329844-w969lczb 61 36 9 9 CD cord-329844-w969lczb 61 37 ] ] -RRB- cord-329844-w969lczb 61 38 . . . cord-329844-w969lczb 62 1 Even even RB cord-329844-w969lczb 62 2 though though IN cord-329844-w969lczb 62 3 such such JJ cord-329844-w969lczb 62 4 glycan glycan NN cord-329844-w969lczb 62 5 binding bind VBG cord-329844-w969lczb 62 6 domains domain NNS cord-329844-w969lczb 62 7 and and CC cord-329844-w969lczb 62 8 enzymes enzyme NNS cord-329844-w969lczb 62 9 as as IN cord-329844-w969lczb 62 10 neuraminidases neuraminidase NNS cord-329844-w969lczb 62 11 are be VBP cord-329844-w969lczb 62 12 found find VBN cord-329844-w969lczb 62 13 in in IN cord-329844-w969lczb 62 14 many many JJ cord-329844-w969lczb 62 15 coronaviruses coronaviruse NNS cord-329844-w969lczb 62 16 , , , cord-329844-w969lczb 62 17 there there EX cord-329844-w969lczb 62 18 seems seem VBZ cord-329844-w969lczb 62 19 to to TO cord-329844-w969lczb 62 20 be be VB cord-329844-w969lczb 62 21 no no DT cord-329844-w969lczb 62 22 such such JJ cord-329844-w969lczb 62 23 enzymes enzyme NNS cord-329844-w969lczb 62 24 in in IN cord-329844-w969lczb 62 25 SARS SARS NNP cord-329844-w969lczb 62 26 - - HYPH cord-329844-w969lczb 62 27 CoV CoV NNP cord-329844-w969lczb 62 28 and and CC cord-329844-w969lczb 62 29 SARS SARS NNP cord-329844-w969lczb 62 30 - - HYPH cord-329844-w969lczb 62 31 CoV-2 CoV-2 NNP cord-329844-w969lczb 62 32 . . . cord-329844-w969lczb 63 1 Viruses virus NNS cord-329844-w969lczb 63 2 of of IN cord-329844-w969lczb 63 3 the the DT cord-329844-w969lczb 63 4 lower low JJR cord-329844-w969lczb 63 5 respiratory respiratory JJ cord-329844-w969lczb 63 6 tract tract NN cord-329844-w969lczb 63 7 , , , cord-329844-w969lczb 63 8 such such JJ cord-329844-w969lczb 63 9 as as IN cord-329844-w969lczb 63 10 influenza influenza NN cord-329844-w969lczb 63 11 virus virus NN cord-329844-w969lczb 63 12 , , , cord-329844-w969lczb 63 13 respiratory respiratory JJ cord-329844-w969lczb 63 14 syncytial syncytial JJ cord-329844-w969lczb 63 15 virus virus NN cord-329844-w969lczb 63 16 , , , cord-329844-w969lczb 63 17 and and CC cord-329844-w969lczb 63 18 SARS SARS NNP cord-329844-w969lczb 63 19 - - HYPH cord-329844-w969lczb 63 20 related relate VBN cord-329844-w969lczb 63 21 coronaviruses coronaviruse NNS cord-329844-w969lczb 63 22 , , , cord-329844-w969lczb 63 23 are be VBP cord-329844-w969lczb 63 24 generally generally RB cord-329844-w969lczb 63 25 considered consider VBN cord-329844-w969lczb 63 26 as as IN cord-329844-w969lczb 63 27 having have VBG cord-329844-w969lczb 63 28 key key JJ cord-329844-w969lczb 63 29 differences difference NNS cord-329844-w969lczb 63 30 that that WDT cord-329844-w969lczb 63 31 require require VBP cord-329844-w969lczb 63 32 different different JJ cord-329844-w969lczb 63 33 therapeutics therapeutic NNS cord-329844-w969lczb 63 34 [ [ -LRB- cord-329844-w969lczb 63 35 10 10 CD cord-329844-w969lczb 63 36 ] ] -RRB- cord-329844-w969lczb 63 37 even even RB cord-329844-w969lczb 63 38 though though IN cord-329844-w969lczb 63 39 relatively relatively RB cord-329844-w969lczb 63 40 little little JJ cord-329844-w969lczb 63 41 is be VBZ cord-329844-w969lczb 63 42 lost lose VBN cord-329844-w969lczb 63 43 in in IN cord-329844-w969lczb 63 44 considering consider VBG cord-329844-w969lczb 63 45 already already RB cord-329844-w969lczb 63 46 approved approve VBN cord-329844-w969lczb 63 47 drugs drug NNS cord-329844-w969lczb 63 48 for for IN cord-329844-w969lczb 63 49 one one CD cord-329844-w969lczb 63 50 of of IN cord-329844-w969lczb 63 51 such such JJ cord-329844-w969lczb 63 52 viruses virus NNS cord-329844-w969lczb 63 53 against against IN cord-329844-w969lczb 63 54 the the DT cord-329844-w969lczb 63 55 other other JJ cord-329844-w969lczb 63 56 ( ( -LRB- cord-329844-w969lczb 63 57 e.g. e.g. RB cord-329844-w969lczb 63 58 Ref Ref NNP cord-329844-w969lczb 63 59 [ [ -LRB- cord-329844-w969lczb 63 60 11 11 CD cord-329844-w969lczb 63 61 ] ] -RRB- cord-329844-w969lczb 63 62 ) ) -RRB- cord-329844-w969lczb 63 63 . . . cord-329844-w969lczb 64 1 Typically typically RB cord-329844-w969lczb 64 2 , , , cord-329844-w969lczb 64 3 the the DT cord-329844-w969lczb 64 4 apparent apparent JJ cord-329844-w969lczb 64 5 absence absence NN cord-329844-w969lczb 64 6 of of IN cord-329844-w969lczb 64 7 glycan glycan NN cord-329844-w969lczb 64 8 binding binding NN cord-329844-w969lczb 64 9 and and CC cord-329844-w969lczb 64 10 enzymic enzymic NNP cord-329844-w969lczb 64 11 sites site NNS cord-329844-w969lczb 64 12 in in IN cord-329844-w969lczb 64 13 SARS SARS NNP cord-329844-w969lczb 64 14 - - HYPH cord-329844-w969lczb 64 15 CoV CoV NNP cord-329844-w969lczb 64 16 and and CC cord-329844-w969lczb 64 17 SARS SARS NNP cord-329844-w969lczb 64 18 - - HYPH cord-329844-w969lczb 64 19 CoV-2 CoV-2 NNP cord-329844-w969lczb 64 20 has have VBZ cord-329844-w969lczb 64 21 been be VBN cord-329844-w969lczb 64 22 dismissed dismiss VBN cord-329844-w969lczb 64 23 as as IN cord-329844-w969lczb 64 24 due due IN cord-329844-w969lczb 64 25 to to IN cord-329844-w969lczb 64 26 the the DT cord-329844-w969lczb 64 27 fact fact NN cord-329844-w969lczb 64 28 that that IN cord-329844-w969lczb 64 29 the the DT cord-329844-w969lczb 64 30 virus virus NN cord-329844-w969lczb 64 31 enters enter VBZ cord-329844-w969lczb 64 32 on on IN cord-329844-w969lczb 64 33 ACE2 ACE2 NNP cord-329844-w969lczb 64 34 , , , cord-329844-w969lczb 64 35 i.e. i.e. FW cord-329844-w969lczb 64 36 angiotensin angiotensin NN cord-329844-w969lczb 64 37 converting convert VBG cord-329844-w969lczb 64 38 enzyme enzyme NN cord-329844-w969lczb 64 39 type type NN cord-329844-w969lczb 64 40 2 2 CD cord-329844-w969lczb 64 41 ( ( -LRB- cord-329844-w969lczb 64 42 e.g. e.g. RB cord-329844-w969lczb 64 43 see see VB cord-329844-w969lczb 64 44 Ref Ref NNP cord-329844-w969lczb 64 45 [ [ -LRB- cord-329844-w969lczb 64 46 5 5 CD cord-329844-w969lczb 64 47 ] ] -RRB- cord-329844-w969lczb 64 48 for for IN cord-329844-w969lczb 64 49 discussion discussion NN cord-329844-w969lczb 64 50 ) ) -RRB- cord-329844-w969lczb 64 51 , , , cord-329844-w969lczb 64 52 not not RB cord-329844-w969lczb 64 53 on on IN cord-329844-w969lczb 64 54 a a DT cord-329844-w969lczb 64 55 glycoprotein glycoprotein NN cord-329844-w969lczb 64 56 . . . cord-329844-w969lczb 65 1 This this DT cord-329844-w969lczb 65 2 does do VBZ cord-329844-w969lczb 65 3 not not RB cord-329844-w969lczb 65 4 , , , cord-329844-w969lczb 65 5 however however RB cord-329844-w969lczb 65 6 , , , cord-329844-w969lczb 65 7 escape escape VB cord-329844-w969lczb 65 8 from from IN cord-329844-w969lczb 65 9 the the DT cord-329844-w969lczb 65 10 intuitively intuitively RB cord-329844-w969lczb 65 11 important important JJ cord-329844-w969lczb 65 12 need need NN cord-329844-w969lczb 65 13 for for IN cord-329844-w969lczb 65 14 preliminary preliminary JJ cord-329844-w969lczb 65 15 binding binding NN cord-329844-w969lczb 65 16 , , , cord-329844-w969lczb 65 17 cell cell NN cord-329844-w969lczb 65 18 entry entry NN cord-329844-w969lczb 65 19 and and CC cord-329844-w969lczb 65 20 exit exit NN cord-329844-w969lczb 65 21 through through IN cord-329844-w969lczb 65 22 the the DT cord-329844-w969lczb 65 23 glycan glycan NN cord-329844-w969lczb 65 24 layer layer NN cord-329844-w969lczb 65 25 , , , cord-329844-w969lczb 65 26 and and CC cord-329844-w969lczb 65 27 probably probably RB cord-329844-w969lczb 65 28 the the DT cord-329844-w969lczb 65 29 decoy decoy NN cord-329844-w969lczb 65 30 - - HYPH cord-329844-w969lczb 65 31 related relate VBN cord-329844-w969lczb 65 32 function function NN cord-329844-w969lczb 65 33 discussed discuss VBN cord-329844-w969lczb 65 34 above above RB cord-329844-w969lczb 65 35 . . . cord-329844-w969lczb 66 1 There there EX cord-329844-w969lczb 66 2 appears appear VBZ cord-329844-w969lczb 66 3 to to TO cord-329844-w969lczb 66 4 be be VB cord-329844-w969lczb 66 5 growing grow VBG cord-329844-w969lczb 66 6 evidence evidence NN cord-329844-w969lczb 66 7 of of IN cord-329844-w969lczb 66 8 significant significant JJ cord-329844-w969lczb 66 9 lectin lectin NN cord-329844-w969lczb 66 10 - - HYPH cord-329844-w969lczb 66 11 binding bind VBG cord-329844-w969lczb 66 12 capability capability NN cord-329844-w969lczb 66 13 . . . cord-329844-w969lczb 67 1 Lectins lectin NNS cord-329844-w969lczb 67 2 are be VBP cord-329844-w969lczb 67 3 the the DT cord-329844-w969lczb 67 4 carbohydrate carbohydrate NN cord-329844-w969lczb 67 5 - - HYPH cord-329844-w969lczb 67 6 binding bind VBG cord-329844-w969lczb 67 7 proteins protein NNS cord-329844-w969lczb 67 8 that that WDT cord-329844-w969lczb 67 9 are be VBP cord-329844-w969lczb 67 10 highly highly RB cord-329844-w969lczb 67 11 specific specific JJ cord-329844-w969lczb 67 12 for for IN cord-329844-w969lczb 67 13 sugar sugar NN cord-329844-w969lczb 67 14 groups group NNS cord-329844-w969lczb 67 15 of of IN cord-329844-w969lczb 67 16 other other JJ cord-329844-w969lczb 67 17 molecules molecule NNS cord-329844-w969lczb 67 18 . . . cord-329844-w969lczb 68 1 Activation activation NN cord-329844-w969lczb 68 2 of of IN cord-329844-w969lczb 68 3 Ctype Ctype NNP cord-329844-w969lczb 68 4 lectin lectin NN cord-329844-w969lczb 68 5 receptor receptor NN cord-329844-w969lczb 68 6 and and CC cord-329844-w969lczb 68 7 other other JJ cord-329844-w969lczb 68 8 similar similar JJ cord-329844-w969lczb 68 9 receptors receptor NNS cord-329844-w969lczb 68 10 contributes contribute VBZ cord-329844-w969lczb 68 11 to to IN cord-329844-w969lczb 68 12 pro pro JJ cord-329844-w969lczb 68 13 - - JJ cord-329844-w969lczb 68 14 inflammatory inflammatory JJ cord-329844-w969lczb 68 15 response response NN cord-329844-w969lczb 68 16 to to IN cord-329844-w969lczb 68 17 many many JJ cord-329844-w969lczb 68 18 coronavirus coronavirus NN cord-329844-w969lczb 68 19 infections infection NNS cord-329844-w969lczb 68 20 . . . cord-329844-w969lczb 69 1 There there EX cord-329844-w969lczb 69 2 also also RB cord-329844-w969lczb 69 3 are be VBP cord-329844-w969lczb 69 4 studies study NNS cord-329844-w969lczb 69 5 over over IN cord-329844-w969lczb 69 6 several several JJ cord-329844-w969lczb 69 7 years year NNS cord-329844-w969lczb 69 8 that that WDT cord-329844-w969lczb 69 9 locate locate VBP cord-329844-w969lczb 69 10 glycan glycan NN cord-329844-w969lczb 69 11 binding binding NN cord-329844-w969lczb 69 12 and and CC cord-329844-w969lczb 69 13 even even RB cord-329844-w969lczb 69 14 related related JJ cord-329844-w969lczb 69 15 catalytic catalytic JJ cord-329844-w969lczb 69 16 activities activity NNS cord-329844-w969lczb 69 17 in in IN cord-329844-w969lczb 69 18 the the DT cord-329844-w969lczb 69 19 spike spike NN cord-329844-w969lczb 69 20 glycoprotein glycoprotein NN cord-329844-w969lczb 69 21 . . . cord-329844-w969lczb 70 1 It -PRON- PRP cord-329844-w969lczb 70 2 has have VBZ cord-329844-w969lczb 70 3 been be VBN cord-329844-w969lczb 70 4 noted note VBN cord-329844-w969lczb 70 5 that that IN cord-329844-w969lczb 70 6 E3 e3 NN cord-329844-w969lczb 70 7 protein protein NN cord-329844-w969lczb 70 8 of of IN cord-329844-w969lczb 70 9 bovine bovine JJ cord-329844-w969lczb 70 10 coronavirus coronavirus NN cord-329844-w969lczb 70 11 is be VBZ cord-329844-w969lczb 70 12 a a DT cord-329844-w969lczb 70 13 receptor receptor NN cord-329844-w969lczb 70 14 - - HYPH cord-329844-w969lczb 70 15 destroying destroy VBG cord-329844-w969lczb 70 16 enzyme enzyme NN cord-329844-w969lczb 70 17 with with IN cord-329844-w969lczb 70 18 acetylesterase acetylesterase NN cord-329844-w969lczb 70 19 activity activity NN cord-329844-w969lczb 70 20 [ [ -LRB- cord-329844-w969lczb 70 21 8 8 CD cord-329844-w969lczb 70 22 ] ] -RRB- cord-329844-w969lczb 70 23 , , , cord-329844-w969lczb 70 24 and and CC cord-329844-w969lczb 70 25 the the DT cord-329844-w969lczb 70 26 3D 3d JJ cord-329844-w969lczb 70 27 structure structure NN cord-329844-w969lczb 70 28 of of IN cord-329844-w969lczb 70 29 coronavirus coronavirus NN cord-329844-w969lczb 70 30 hemagglutinin hemagglutinin NN cord-329844-w969lczb 70 31 - - HYPH cord-329844-w969lczb 70 32 esterase esterase NN cord-329844-w969lczb 70 33 offered offer VBD cord-329844-w969lczb 70 34 insight insight NN cord-329844-w969lczb 70 35 into into IN cord-329844-w969lczb 70 36 coronavirus coronavirus NN cord-329844-w969lczb 70 37 and and CC cord-329844-w969lczb 70 38 influenza influenza NN cord-329844-w969lczb 70 39 virus virus NN cord-329844-w969lczb 70 40 evolution evolution NN cord-329844-w969lczb 70 41 , , , cord-329844-w969lczb 70 42 with with IN cord-329844-w969lczb 70 43 implications implication NNS cord-329844-w969lczb 70 44 for for IN cord-329844-w969lczb 70 45 drug drug NN cord-329844-w969lczb 70 46 and and CC cord-329844-w969lczb 70 47 antibody antibody NN cord-329844-w969lczb 70 48 discovery discovery NN cord-329844-w969lczb 70 49 [ [ -LRB- cord-329844-w969lczb 70 50 9 9 CD cord-329844-w969lczb 70 51 ] ] -RRB- cord-329844-w969lczb 70 52 . . . cord-329844-w969lczb 71 1 The the DT cord-329844-w969lczb 71 2 location location NN cord-329844-w969lczb 71 3 of of IN cord-329844-w969lczb 71 4 any any DT cord-329844-w969lczb 71 5 sialic sialic JJ cord-329844-w969lczb 71 6 acid acid NN cord-329844-w969lczb 71 7 glycan glycan NN cord-329844-w969lczb 71 8 binding bind VBG cord-329844-w969lczb 71 9 region region NN cord-329844-w969lczb 71 10 of of IN cord-329844-w969lczb 71 11 SARS SARS NNP cord-329844-w969lczb 71 12 - - HYPH cord-329844-w969lczb 71 13 CoV-2 CoV-2 NNP cord-329844-w969lczb 71 14 is be VBZ cord-329844-w969lczb 71 15 , , , cord-329844-w969lczb 71 16 a a DT cord-329844-w969lczb 71 17 priori priori RB cord-329844-w969lczb 71 18 unclear unclear JJ cord-329844-w969lczb 71 19 , , , cord-329844-w969lczb 71 20 although although IN cord-329844-w969lczb 71 21 intuitively intuitively RB cord-329844-w969lczb 71 22 ( ( -LRB- cord-329844-w969lczb 71 23 a a LS cord-329844-w969lczb 71 24 ) ) -RRB- cord-329844-w969lczb 71 25 it -PRON- PRP cord-329844-w969lczb 71 26 would would MD cord-329844-w969lczb 71 27 likely likely RB cord-329844-w969lczb 71 28 be be VB cord-329844-w969lczb 71 29 associated associate VBN cord-329844-w969lczb 71 30 with with IN cord-329844-w969lczb 71 31 the the DT cord-329844-w969lczb 71 32 cap cap NN cord-329844-w969lczb 71 33 or or CC cord-329844-w969lczb 71 34 knob knob NN cord-329844-w969lczb 71 35 at at IN cord-329844-w969lczb 71 36 the the DT cord-329844-w969lczb 71 37 outer outer JJ cord-329844-w969lczb 71 38 end end NN cord-329844-w969lczb 71 39 of of IN cord-329844-w969lczb 71 40 the the DT cord-329844-w969lczb 71 41 spike spike NN cord-329844-w969lczb 71 42 protein protein NN cord-329844-w969lczb 71 43 , , , cord-329844-w969lczb 71 44 or or CC cord-329844-w969lczb 71 45 ( ( -LRB- cord-329844-w969lczb 71 46 b b NN cord-329844-w969lczb 71 47 ) ) -RRB- cord-329844-w969lczb 71 48 at at IN cord-329844-w969lczb 71 49 least least JJS cord-329844-w969lczb 71 50 not not RB cord-329844-w969lczb 71 51 involve involve VB cord-329844-w969lczb 71 52 exactly exactly RB cord-329844-w969lczb 71 53 the the DT cord-329844-w969lczb 71 54 same same JJ cord-329844-w969lczb 71 55 domain domain NN cord-329844-w969lczb 71 56 as as IN cord-329844-w969lczb 71 57 is be VBZ cord-329844-w969lczb 71 58 required require VBN cord-329844-w969lczb 71 59 for for IN cord-329844-w969lczb 71 60 other other JJ cord-329844-w969lczb 71 61 important important JJ cord-329844-w969lczb 71 62 functions function NNS cord-329844-w969lczb 71 63 . . . cord-329844-w969lczb 72 1 Although although IN cord-329844-w969lczb 72 2 throughout throughout IN cord-329844-w969lczb 72 3 the the DT cord-329844-w969lczb 72 4 coronaviruses coronaviruse NNS cord-329844-w969lczb 72 5 various various JJ cord-329844-w969lczb 72 6 external external JJ cord-329844-w969lczb 72 7 proteins protein NNS cord-329844-w969lczb 72 8 and and CC cord-329844-w969lczb 72 9 domains domain NNS cord-329844-w969lczb 72 10 can can MD cord-329844-w969lczb 72 11 recognize recognize VB cord-329844-w969lczb 72 12 either either CC cord-329844-w969lczb 72 13 protein protein NN cord-329844-w969lczb 72 14 or or CC cord-329844-w969lczb 72 15 sugar sugar NN cord-329844-w969lczb 72 16 receptors receptor NNS cord-329844-w969lczb 72 17 or or CC cord-329844-w969lczb 72 18 both both DT cord-329844-w969lczb 72 19 , , , cord-329844-w969lczb 72 20 the the DT cord-329844-w969lczb 72 21 majority majority NN cord-329844-w969lczb 72 22 of of IN cord-329844-w969lczb 72 23 such such JJ cord-329844-w969lczb 72 24 studies study NNS cord-329844-w969lczb 72 25 like like IN cord-329844-w969lczb 72 26 those those DT cord-329844-w969lczb 72 27 above above RB cord-329844-w969lczb 72 28 implicate implicate VBP cord-329844-w969lczb 72 29 the the DT cord-329844-w969lczb 72 30 S1 s1 NN cord-329844-w969lczb 72 31 region region NN cord-329844-w969lczb 72 32 in in IN cord-329844-w969lczb 72 33 their -PRON- PRP$ cord-329844-w969lczb 72 34 spike spike NN cord-329844-w969lczb 72 35 glycoproteins glycoprotein NNS cord-329844-w969lczb 72 36 , , , cord-329844-w969lczb 72 37 but but CC cord-329844-w969lczb 72 38 as as IN cord-329844-w969lczb 72 39 discussed discuss VBN cord-329844-w969lczb 72 40 in in IN cord-329844-w969lczb 72 41 the the DT cord-329844-w969lczb 72 42 present present JJ cord-329844-w969lczb 72 43 paper paper NN cord-329844-w969lczb 72 44 , , , cord-329844-w969lczb 72 45 there there EX cord-329844-w969lczb 72 46 are be VBP cord-329844-w969lczb 72 47 other other JJ cord-329844-w969lczb 72 48 potential potential JJ cord-329844-w969lczb 72 49 sugar sugar NN cord-329844-w969lczb 72 50 binding bind VBG cord-329844-w969lczb 72 51 sites site NNS cord-329844-w969lczb 72 52 that that WDT cord-329844-w969lczb 72 53 are be VBP cord-329844-w969lczb 72 54 still still RB cord-329844-w969lczb 72 55 within within IN cord-329844-w969lczb 72 56 the the DT cord-329844-w969lczb 72 57 spike spike NN cord-329844-w969lczb 72 58 protein protein NN cord-329844-w969lczb 72 59 . . . cord-329844-w969lczb 73 1 Overall overall RB cord-329844-w969lczb 73 2 , , , cord-329844-w969lczb 73 3 the the DT cord-329844-w969lczb 73 4 SARS SARS NNP cord-329844-w969lczb 73 5 - - HYPH cord-329844-w969lczb 73 6 CoV-2 CoV-2 NNP cord-329844-w969lczb 73 7 spike spike NN cord-329844-w969lczb 73 8 glycoprotein glycoprotein NN cord-329844-w969lczb 73 9 has have VBZ cord-329844-w969lczb 73 10 1273 1273 CD cord-329844-w969lczb 73 11 amino amino NN cord-329844-w969lczb 73 12 acid acid NN cord-329844-w969lczb 73 13 residues residue NNS cord-329844-w969lczb 73 14 and and CC cord-329844-w969lczb 73 15 until until IN cord-329844-w969lczb 73 16 early early JJ cord-329844-w969lczb 73 17 2020 2020 CD cord-329844-w969lczb 73 18 understanding understanding NN cord-329844-w969lczb 73 19 of of IN cord-329844-w969lczb 73 20 structure structure NN cord-329844-w969lczb 73 21 was be VBD cord-329844-w969lczb 73 22 heavily heavily RB cord-329844-w969lczb 73 23 based base VBN cord-329844-w969lczb 73 24 on on IN cord-329844-w969lczb 73 25 SARS SARS NNP cord-329844-w969lczb 73 26 - - HYPH cord-329844-w969lczb 73 27 CoV CoV NNP cord-329844-w969lczb 73 28 spike spike NN cord-329844-w969lczb 73 29 glycoprotein glycoprotein NN cord-329844-w969lczb 73 30 ( ( -LRB- cord-329844-w969lczb 73 31 1255 1255 CD cord-329844-w969lczb 73 32 amino amino JJ cord-329844-w969lczb 73 33 acids acid NNS cord-329844-w969lczb 73 34 ) ) -RRB- cord-329844-w969lczb 73 35 with with IN cord-329844-w969lczb 73 36 20 20 CD cord-329844-w969lczb 73 37 - - SYM cord-329844-w969lczb 73 38 27 27 CD cord-329844-w969lczb 73 39 % % NN cord-329844-w969lczb 73 40 amino amino NN cord-329844-w969lczb 73 41 acid acid NN cord-329844-w969lczb 73 42 residues residue NNS cord-329844-w969lczb 73 43 similarity similarity NN cord-329844-w969lczb 73 44 among among IN cord-329844-w969lczb 73 45 non non JJ cord-329844-w969lczb 73 46 - - JJ cord-329844-w969lczb 73 47 SARS sars JJ cord-329844-w969lczb 73 48 coronaviruses coronaviruse NNS cord-329844-w969lczb 73 49 . . . cord-329844-w969lczb 74 1 Most Most JJS cord-329844-w969lczb 74 2 of of IN cord-329844-w969lczb 74 3 the the DT cord-329844-w969lczb 74 4 spike spike NN cord-329844-w969lczb 74 5 protein protein NN cord-329844-w969lczb 74 6 appears appear VBZ cord-329844-w969lczb 74 7 to to TO cord-329844-w969lczb 74 8 be be VB cord-329844-w969lczb 74 9 involved involve VBN cord-329844-w969lczb 74 10 in in IN cord-329844-w969lczb 74 11 the the DT cord-329844-w969lczb 74 12 specific specific JJ cord-329844-w969lczb 74 13 stages stage NNS cord-329844-w969lczb 74 14 of of IN cord-329844-w969lczb 74 15 cell cell NN cord-329844-w969lczb 74 16 entry entry NN cord-329844-w969lczb 74 17 . . . cord-329844-w969lczb 75 1 The the DT cord-329844-w969lczb 75 2 spike spike NN cord-329844-w969lczb 75 3 glycoprotein glycoprotein NN cord-329844-w969lczb 75 4 of of IN cord-329844-w969lczb 75 5 SARS SARS NNP cord-329844-w969lczb 75 6 - - HYPH cord-329844-w969lczb 75 7 CoV CoV NNP cord-329844-w969lczb 75 8 and and CC cord-329844-w969lczb 75 9 SARS SARS NNP cord-329844-w969lczb 75 10 - - HYPH cord-329844-w969lczb 75 11 CoV-2 CoV-2 NNP cord-329844-w969lczb 75 12 is be VBZ cord-329844-w969lczb 75 13 translated translate VBN cord-329844-w969lczb 75 14 as as IN cord-329844-w969lczb 75 15 a a DT cord-329844-w969lczb 75 16 large large JJ cord-329844-w969lczb 75 17 polypeptide polypeptide NN cord-329844-w969lczb 75 18 that that WDT cord-329844-w969lczb 75 19 is be VBZ cord-329844-w969lczb 75 20 later later RB cord-329844-w969lczb 75 21 cleaved cleave VBN cord-329844-w969lczb 75 22 to to IN cord-329844-w969lczb 75 23 S1 S1 NNP cord-329844-w969lczb 75 24 and and CC cord-329844-w969lczb 75 25 S2 s2 NN cord-329844-w969lczb 75 26 sites site NNS cord-329844-w969lczb 75 27 . . . cord-329844-w969lczb 76 1 After after IN cord-329844-w969lczb 76 2 binding bind VBG cord-329844-w969lczb 76 3 to to IN cord-329844-w969lczb 76 4 the the DT cord-329844-w969lczb 76 5 main main JJ cord-329844-w969lczb 76 6 receptor receptor NN cord-329844-w969lczb 76 7 that that IN cord-329844-w969lczb 76 8 that that WDT cord-329844-w969lczb 76 9 is be VBZ cord-329844-w969lczb 76 10 held hold VBN cord-329844-w969lczb 76 11 to to TO cord-329844-w969lczb 76 12 be be VB cord-329844-w969lczb 76 13 primarily primarily RB cord-329844-w969lczb 76 14 ACE2 ACE2 NNP cord-329844-w969lczb 76 15 , , , cord-329844-w969lczb 76 16 the the DT cord-329844-w969lczb 76 17 host host NN cord-329844-w969lczb 76 18 proteases protease NNS cord-329844-w969lczb 76 19 activate activate VBP cord-329844-w969lczb 76 20 the the DT cord-329844-w969lczb 76 21 virus virus NN cord-329844-w969lczb 76 22 by by IN cord-329844-w969lczb 76 23 cleaving cleave VBG cord-329844-w969lczb 76 24 first first RB cord-329844-w969lczb 76 25 at at IN cord-329844-w969lczb 76 26 the the DT cord-329844-w969lczb 76 27 S1 S1 NNP cord-329844-w969lczb 76 28 / / SYM cord-329844-w969lczb 76 29 S2 S2 NNP cord-329844-w969lczb 76 30 boundary boundary NN cord-329844-w969lczb 76 31 ( ( -LRB- cord-329844-w969lczb 76 32 i.e. i.e. FW cord-329844-w969lczb 76 33 S1 S1 NNP cord-329844-w969lczb 76 34 / / SYM cord-329844-w969lczb 76 35 S2 S2 NNP cord-329844-w969lczb 76 36 site site NN cord-329844-w969lczb 76 37 ) ) -RRB- cord-329844-w969lczb 76 38 and and CC cord-329844-w969lczb 76 39 then then RB cord-329844-w969lczb 76 40 within within IN cord-329844-w969lczb 76 41 S2 s2 NN cord-329844-w969lczb 76 42 , , , cord-329844-w969lczb 76 43 i.e. i.e. FW cord-329844-w969lczb 76 44 at at IN cord-329844-w969lczb 76 45 the the DT cord-329844-w969lczb 76 46 S2 S2 NNP cord-329844-w969lczb 76 47 ' ' '' cord-329844-w969lczb 76 48 site site NN cord-329844-w969lczb 76 49 . . . cord-329844-w969lczb 77 1 The the DT cord-329844-w969lczb 77 2 spike spike NN cord-329844-w969lczb 77 3 of of IN cord-329844-w969lczb 77 4 similar similar JJ cord-329844-w969lczb 77 5 coronavirus coronavirus NN cord-329844-w969lczb 77 6 have have VBP cord-329844-w969lczb 77 7 long long RB cord-329844-w969lczb 77 8 been be VBN cord-329844-w969lczb 77 9 considered consider VBN cord-329844-w969lczb 77 10 as as IN cord-329844-w969lczb 77 11 being be VBG cord-329844-w969lczb 77 12 in in IN cord-329844-w969lczb 77 13 two two CD cord-329844-w969lczb 77 14 main main JJ cord-329844-w969lczb 77 15 states state NNS cord-329844-w969lczb 77 16 ( ( -LRB- cord-329844-w969lczb 77 17 i i NN cord-329844-w969lczb 77 18 ) ) -RRB- cord-329844-w969lczb 77 19 the the DT cord-329844-w969lczb 77 20 pre pre JJ cord-329844-w969lczb 77 21 - - JJ cord-329844-w969lczb 77 22 fusion fusion JJ cord-329844-w969lczb 77 23 form form NN cord-329844-w969lczb 77 24 ( ( -LRB- cord-329844-w969lczb 77 25 the the DT cord-329844-w969lczb 77 26 form form NN cord-329844-w969lczb 77 27 of of IN cord-329844-w969lczb 77 28 the the DT cord-329844-w969lczb 77 29 mature mature JJ cord-329844-w969lczb 77 30 virion virion NN cord-329844-w969lczb 77 31 ) ) -RRB- cord-329844-w969lczb 77 32 and and CC cord-329844-w969lczb 77 33 ( ( -LRB- cord-329844-w969lczb 77 34 ii ii LS cord-329844-w969lczb 77 35 ) ) -RRB- cord-329844-w969lczb 77 36 post post JJ cord-329844-w969lczb 77 37 - - JJ cord-329844-w969lczb 77 38 fusion fusion JJ cord-329844-w969lczb 77 39 form form NN cord-329844-w969lczb 77 40 , , , cord-329844-w969lczb 77 41 the the DT cord-329844-w969lczb 77 42 form form NN cord-329844-w969lczb 77 43 after after IN cord-329844-w969lczb 77 44 membrane membrane NN cord-329844-w969lczb 77 45 fusion fusion NN cord-329844-w969lczb 77 46 has have VBZ cord-329844-w969lczb 77 47 been be VBN cord-329844-w969lczb 77 48 completed complete VBN cord-329844-w969lczb 77 49 ) ) -RRB- cord-329844-w969lczb 77 50 . . . cord-329844-w969lczb 78 1 More more RBR cord-329844-w969lczb 78 2 detailed detailed JJ cord-329844-w969lczb 78 3 studies study NNS cord-329844-w969lczb 78 4 have have VBP cord-329844-w969lczb 78 5 split split VBN cord-329844-w969lczb 78 6 the the DT cord-329844-w969lczb 78 7 latter latter JJ cord-329844-w969lczb 78 8 into into IN cord-329844-w969lczb 78 9 a a DT cord-329844-w969lczb 78 10 prehairpin prehairpin NNP cord-329844-w969lczb 78 11 intermediate intermediate JJ cord-329844-w969lczb 78 12 state state NN cord-329844-w969lczb 78 13 , , , cord-329844-w969lczb 78 14 and and CC cord-329844-w969lczb 78 15 post post JJ cord-329844-w969lczb 78 16 - - JJ cord-329844-w969lczb 78 17 fusion fusion JJ cord-329844-w969lczb 78 18 hairpin hairpin NN cord-329844-w969lczb 78 19 state state NN cord-329844-w969lczb 78 20 . . . cord-329844-w969lczb 79 1 Somewhat somewhat RB cord-329844-w969lczb 79 2 like like IN cord-329844-w969lczb 79 3 in in IN cord-329844-w969lczb 79 4 all all DT cord-329844-w969lczb 80 1 virus virus NN cord-329844-w969lczb 80 2 Class class NN cord-329844-w969lczb 80 3 I -PRON- PRP cord-329844-w969lczb 80 4 fusion fusion NN cord-329844-w969lczb 80 5 proteins protein NNS cord-329844-w969lczb 80 6 , , , cord-329844-w969lczb 80 7 the the DT cord-329844-w969lczb 80 8 S2 S2 NNP cord-329844-w969lczb 80 9 protein protein NN cord-329844-w969lczb 80 10 contains contain VBZ cord-329844-w969lczb 80 11 two two CD cord-329844-w969lczb 80 12 heptad heptad NN cord-329844-w969lczb 80 13 repeat repeat NN cord-329844-w969lczb 80 14 regions region NNS cord-329844-w969lczb 80 15 ( ( -LRB- cord-329844-w969lczb 80 16 HRs hr NNS cord-329844-w969lczb 80 17 ) ) -RRB- cord-329844-w969lczb 80 18 of of IN cord-329844-w969lczb 80 19 which which WDT cord-329844-w969lczb 80 20 one one NN cord-329844-w969lczb 80 21 ( ( -LRB- cord-329844-w969lczb 80 22 HR2 HR2 NNP cord-329844-w969lczb 80 23 ) ) -RRB- cord-329844-w969lczb 80 24 is be VBZ cord-329844-w969lczb 80 25 located locate VBN cord-329844-w969lczb 80 26 close close RB cord-329844-w969lczb 80 27 to to IN cord-329844-w969lczb 80 28 the the DT cord-329844-w969lczb 80 29 transmembrane transmembrane NNP cord-329844-w969lczb 80 30 anchor anchor NN cord-329844-w969lczb 80 31 . . . cord-329844-w969lczb 81 1 Membrane membrane NN cord-329844-w969lczb 81 2 fusion fusion NN cord-329844-w969lczb 81 3 occurs occur VBZ cord-329844-w969lczb 81 4 when when WRB cord-329844-w969lczb 81 5 there there EX cord-329844-w969lczb 81 6 is be VBZ cord-329844-w969lczb 81 7 a a DT cord-329844-w969lczb 81 8 conformational conformational JJ cord-329844-w969lczb 81 9 change change NN cord-329844-w969lczb 81 10 in in IN cord-329844-w969lczb 81 11 the the DT cord-329844-w969lczb 81 12 HRs hr NNS cord-329844-w969lczb 81 13 to to TO cord-329844-w969lczb 81 14 form form VB cord-329844-w969lczb 81 15 a a DT cord-329844-w969lczb 81 16 fusion fusion NN cord-329844-w969lczb 81 17 core core NN cord-329844-w969lczb 81 18 . . . cord-329844-w969lczb 82 1 The the DT cord-329844-w969lczb 82 2 HRs hr NNS cord-329844-w969lczb 82 3 of of IN cord-329844-w969lczb 82 4 the the DT cord-329844-w969lczb 82 5 protein protein NN cord-329844-w969lczb 82 6 fold fold VBG cord-329844-w969lczb 82 7 into into IN cord-329844-w969lczb 82 8 a a DT cord-329844-w969lczb 82 9 coiled coil VBN cord-329844-w969lczb 82 10 - - HYPH cord-329844-w969lczb 82 11 coil coil NN cord-329844-w969lczb 82 12 structure structure NN cord-329844-w969lczb 82 13 , , , cord-329844-w969lczb 82 14 known know VBN cord-329844-w969lczb 82 15 as as IN cord-329844-w969lczb 82 16 the the DT cord-329844-w969lczb 82 17 " " `` cord-329844-w969lczb 82 18 fusogenic fusogenic JJ cord-329844-w969lczb 82 19 state state NN cord-329844-w969lczb 82 20 " " '' cord-329844-w969lczb 82 21 . . . cord-329844-w969lczb 83 1 As as IN cord-329844-w969lczb 83 2 virus virus NN cord-329844-w969lczb 83 3 and and CC cord-329844-w969lczb 83 4 target target NN cord-329844-w969lczb 83 5 cell cell NN cord-329844-w969lczb 83 6 membranes membrane NNS cord-329844-w969lczb 83 7 fuse fuse NN cord-329844-w969lczb 83 8 , , , cord-329844-w969lczb 83 9 the the DT cord-329844-w969lczb 83 10 coiled coiled JJ cord-329844-w969lczb 83 11 coil coil NN cord-329844-w969lczb 83 12 regions region NNS cord-329844-w969lczb 83 13 ( ( -LRB- cord-329844-w969lczb 83 14 called call VBN cord-329844-w969lczb 83 15 heptad heptad NNP cord-329844-w969lczb 83 16 repeats repeat VBZ cord-329844-w969lczb 83 17 ) ) -RRB- cord-329844-w969lczb 83 18 become become VBP cord-329844-w969lczb 83 19 a a DT cord-329844-w969lczb 83 20 trimer trimer NN cord-329844-w969lczb 83 21 - - HYPH cord-329844-w969lczb 83 22 of of IN cord-329844-w969lczb 83 23 - - HYPH cord-329844-w969lczb 83 24 hairpins hairpin NNS cord-329844-w969lczb 83 25 structure structure NN cord-329844-w969lczb 83 26 . . . cord-329844-w969lczb 84 1 The the DT cord-329844-w969lczb 84 2 S2 s2 NN cord-329844-w969lczb 84 3 ' ' '' cord-329844-w969lczb 84 4 cleavage cleavage NN cord-329844-w969lczb 84 5 site site NN cord-329844-w969lczb 84 6 appears appear VBZ cord-329844-w969lczb 84 7 particularly particularly RB cord-329844-w969lczb 84 8 important important JJ cord-329844-w969lczb 84 9 by by IN cord-329844-w969lczb 84 10 being be VBG cord-329844-w969lczb 84 11 well well RB cord-329844-w969lczb 84 12 conserved conserve VBN cord-329844-w969lczb 84 13 [ [ -LRB- cord-329844-w969lczb 84 14 3 3 CD cord-329844-w969lczb 84 15 ] ] -RRB- cord-329844-w969lczb 84 16 [ [ -LRB- cord-329844-w969lczb 84 17 4 4 CD cord-329844-w969lczb 84 18 ] ] -RRB- cord-329844-w969lczb 85 1 [ [ -LRB- cord-329844-w969lczb 85 2 5 5 CD cord-329844-w969lczb 85 3 ] ] -RRB- cord-329844-w969lczb 85 4 and and CC cord-329844-w969lczb 85 5 proteolysis proteolysis NN cord-329844-w969lczb 85 6 by by IN cord-329844-w969lczb 85 7 cathepsin cathepsin NN cord-329844-w969lczb 85 8 appears appear VBZ cord-329844-w969lczb 85 9 sufficient sufficient JJ cord-329844-w969lczb 85 10 to to TO cord-329844-w969lczb 85 11 expose expose VB cord-329844-w969lczb 85 12 the the DT cord-329844-w969lczb 85 13 fusion fusion NN cord-329844-w969lczb 85 14 peptide peptide NN cord-329844-w969lczb 85 15 of of IN cord-329844-w969lczb 85 16 S2 S2 NNP cord-329844-w969lczb 85 17 and and CC cord-329844-w969lczb 85 18 activate activate VB cord-329844-w969lczb 85 19 fusion fusion NN cord-329844-w969lczb 85 20 within within IN cord-329844-w969lczb 85 21 the the DT cord-329844-w969lczb 85 22 host host NN cord-329844-w969lczb 85 23 cell cell NN cord-329844-w969lczb 85 24 endosome endosome NN cord-329844-w969lczb 85 25 . . . cord-329844-w969lczb 86 1 In in IN cord-329844-w969lczb 86 2 general general JJ cord-329844-w969lczb 86 3 , , , cord-329844-w969lczb 86 4 S2 S2 NNP cord-329844-w969lczb 86 5 ' ' '' cord-329844-w969lczb 86 6 is be VBZ cord-329844-w969lczb 86 7 now now RB cord-329844-w969lczb 86 8 considered consider VBN cord-329844-w969lczb 86 9 as as IN cord-329844-w969lczb 86 10 the the DT cord-329844-w969lczb 86 11 key key JJ cord-329844-w969lczb 86 12 viral viral JJ cord-329844-w969lczb 86 13 fusion fusion NN cord-329844-w969lczb 86 14 peptide peptide NN cord-329844-w969lczb 86 15 which which WDT cord-329844-w969lczb 86 16 is be VBZ cord-329844-w969lczb 86 17 unmasked unmask VBN cord-329844-w969lczb 86 18 following follow VBG cord-329844-w969lczb 86 19 S2 s2 NN cord-329844-w969lczb 86 20 cleavage cleavage NN cord-329844-w969lczb 86 21 . . . cord-329844-w969lczb 87 1 Subsequently subsequently RB cord-329844-w969lczb 87 2 , , , cord-329844-w969lczb 87 3 S1 S1 NNP cord-329844-w969lczb 87 4 dissociates dissociate VBZ cord-329844-w969lczb 87 5 from from IN cord-329844-w969lczb 87 6 S2 S2 NNP cord-329844-w969lczb 87 7 , , , cord-329844-w969lczb 87 8 allowing allow VBG cord-329844-w969lczb 87 9 S2 S2 NNP cord-329844-w969lczb 87 10 to to TO cord-329844-w969lczb 87 11 transition transition NN cord-329844-w969lczb 87 12 to to IN cord-329844-w969lczb 87 13 the the DT cord-329844-w969lczb 87 14 post post JJ cord-329844-w969lczb 87 15 - - JJ cord-329844-w969lczb 87 16 fusion fusion JJ cord-329844-w969lczb 87 17 structure structure NN cord-329844-w969lczb 87 18 . . . cord-329844-w969lczb 88 1 The the DT cord-329844-w969lczb 88 2 following follow VBG cord-329844-w969lczb 88 3 locations location NNS cord-329844-w969lczb 88 4 in in IN cord-329844-w969lczb 88 5 the the DT cord-329844-w969lczb 88 6 sequences sequence NNS cord-329844-w969lczb 88 7 of of IN cord-329844-w969lczb 88 8 amino amino NN cord-329844-w969lczb 88 9 acid acid NN cord-329844-w969lczb 88 10 residues residue NNS cord-329844-w969lczb 88 11 apply apply VBP cord-329844-w969lczb 88 12 specifically specifically RB cord-329844-w969lczb 88 13 to to IN cord-329844-w969lczb 88 14 SARS SARS NNP cord-329844-w969lczb 88 15 - - HYPH cord-329844-w969lczb 88 16 CoV-2 CoV-2 NNP cord-329844-w969lczb 88 17 . . . cord-329844-w969lczb 89 1 These these DT cord-329844-w969lczb 89 2 vary vary VBP cord-329844-w969lczb 89 3 somewhat somewhat RB cord-329844-w969lczb 89 4 with with IN cord-329844-w969lczb 89 5 author author NN cord-329844-w969lczb 89 6 , , , cord-329844-w969lczb 89 7 and and CC cord-329844-w969lczb 89 8 the the DT cord-329844-w969lczb 89 9 following follow VBG cord-329844-w969lczb 89 10 are be VBP cord-329844-w969lczb 89 11 used use VBN cord-329844-w969lczb 89 12 here here RB cord-329844-w969lczb 89 13 . . . cord-329844-w969lczb 90 1 The the DT cord-329844-w969lczb 90 2 signal signal NN cord-329844-w969lczb 90 3 peptide peptide NN cord-329844-w969lczb 90 4 ( ( -LRB- cord-329844-w969lczb 90 5 SP SP NNP cord-329844-w969lczb 90 6 ) ) -RRB- cord-329844-w969lczb 90 7 comprises comprise VBZ cord-329844-w969lczb 90 8 residues residue NNS cord-329844-w969lczb 90 9 1 1 CD cord-329844-w969lczb 90 10 - - SYM cord-329844-w969lczb 90 11 19 19 CD cord-329844-w969lczb 90 12 . . . cord-329844-w969lczb 91 1 On on IN cord-329844-w969lczb 91 2 the the DT cord-329844-w969lczb 91 3 inside inside NN cord-329844-w969lczb 91 4 of of IN cord-329844-w969lczb 91 5 the the DT cord-329844-w969lczb 91 6 lipid lipid NN cord-329844-w969lczb 91 7 membrane membrane NN cord-329844-w969lczb 91 8 , , , cord-329844-w969lczb 91 9 the the DT cord-329844-w969lczb 91 10 carboxyl carboxyl NN cord-329844-w969lczb 91 11 terminus terminus NN cord-329844-w969lczb 91 12 ( ( -LRB- cord-329844-w969lczb 91 13 C c NN cord-329844-w969lczb 91 14 - - HYPH cord-329844-w969lczb 91 15 terminus terminus NN cord-329844-w969lczb 91 16 ) ) -RRB- cord-329844-w969lczb 91 17 is be VBZ cord-329844-w969lczb 91 18 comprised comprise VBN cord-329844-w969lczb 91 19 of of IN cord-329844-w969lczb 91 20 the the DT cord-329844-w969lczb 91 21 transmembrane transmembrane NNP cord-329844-w969lczb 91 22 region region NN cord-329844-w969lczb 91 23 ( ( -LRB- cord-329844-w969lczb 91 24 TM TM NNP cord-329844-w969lczb 91 25 ) ) -RRB- cord-329844-w969lczb 91 26 comprising comprise VBG cord-329844-w969lczb 91 27 residues residue NNS cord-329844-w969lczb 91 28 1214 1214 CD cord-329844-w969lczb 91 29 - - SYM cord-329844-w969lczb 91 30 1236 1236 CD cord-329844-w969lczb 91 31 and and CC cord-329844-w969lczb 91 32 the the DT cord-329844-w969lczb 91 33 cytoplasmic cytoplasmic JJ cord-329844-w969lczb 91 34 tail tail NN cord-329844-w969lczb 91 35 ( ( -LRB- cord-329844-w969lczb 91 36 CT CT NNP cord-329844-w969lczb 91 37 ) ) -RRB- cord-329844-w969lczb 91 38 residues1237 residues1237 NNP cord-329844-w969lczb 91 39 - - HYPH cord-329844-w969lczb 91 40 1273 1273 CD cord-329844-w969lczb 91 41 . . . cord-329844-w969lczb 92 1 The the DT cord-329844-w969lczb 92 2 extracellular extracellular JJ cord-329844-w969lczb 92 3 domain domain NN cord-329844-w969lczb 92 4 of of IN cord-329844-w969lczb 92 5 the the DT cord-329844-w969lczb 92 6 spike spike NN cord-329844-w969lczb 92 7 glycoprotein glycoprotein NN cord-329844-w969lczb 92 8 is be VBZ cord-329844-w969lczb 92 9 comprised comprise VBN cord-329844-w969lczb 92 10 of of IN cord-329844-w969lczb 92 11 N n CD cord-329844-w969lczb 92 12 - - HYPH cord-329844-w969lczb 92 13 terminal terminal NN cord-329844-w969lczb 92 14 domain domain NN cord-329844-w969lczb 92 15 ( ( -LRB- cord-329844-w969lczb 92 16 S1-NTD S1-NTD NNP cord-329844-w969lczb 92 17 ) ) -RRB- cord-329844-w969lczb 92 18 comprising comprise VBG cord-329844-w969lczb 92 19 residues residue NNS cord-329844-w969lczb 92 20 20 20 CD cord-329844-w969lczb 92 21 - - SYM cord-329844-w969lczb 92 22 286 286 CD cord-329844-w969lczb 92 23 , , , cord-329844-w969lczb 92 24 and and CC cord-329844-w969lczb 92 25 is be VBZ cord-329844-w969lczb 92 26 of of IN cord-329844-w969lczb 92 27 particular particular JJ cord-329844-w969lczb 92 28 interest interest NN cord-329844-w969lczb 92 29 here here RB cord-329844-w969lczb 92 30 . . . cord-329844-w969lczb 93 1 The the DT cord-329844-w969lczb 93 2 host host NN cord-329844-w969lczb 93 3 cell cell NN cord-329844-w969lczb 93 4 receptor receptor NN cord-329844-w969lczb 93 5 binding bind VBG cord-329844-w969lczb 93 6 domain domain NN cord-329844-w969lczb 93 7 ( ( -LRB- cord-329844-w969lczb 93 8 RBD RBD NNP cord-329844-w969lczb 93 9 ) ) -RRB- cord-329844-w969lczb 93 10 comprising comprise VBG cord-329844-w969lczb 93 11 residues residue NNS cord-329844-w969lczb 93 12 319 319 CD cord-329844-w969lczb 93 13 - - SYM cord-329844-w969lczb 93 14 541 541 CD cord-329844-w969lczb 93 15 . . . cord-329844-w969lczb 94 1 In in IN cord-329844-w969lczb 94 2 summary summary NN cord-329844-w969lczb 94 3 the the DT cord-329844-w969lczb 94 4 key key JJ cord-329844-w969lczb 94 5 regions region NNS cord-329844-w969lczb 94 6 are be VBP cord-329844-w969lczb 94 7 as as IN cord-329844-w969lczb 94 8 follows follow VBZ cord-329844-w969lczb 94 9 . . . cord-329844-w969lczb 95 1 SP SP NNP cord-329844-w969lczb 95 2 See See NNP cord-329844-w969lczb 95 3 text text NN cord-329844-w969lczb 95 4 in in IN cord-329844-w969lczb 95 5 regard regard NN cord-329844-w969lczb 95 6 to to IN cord-329844-w969lczb 95 7 the the DT cord-329844-w969lczb 95 8 significance significance NN cord-329844-w969lczb 95 9 of of IN cord-329844-w969lczb 95 10 the the DT cord-329844-w969lczb 95 11 other other JJ cord-329844-w969lczb 95 12 colors color NNS cord-329844-w969lczb 95 13 . . . cord-329844-w969lczb 96 1 Fig Fig NNP cord-329844-w969lczb 96 2 . . NNP cord-329844-w969lczb 96 3 1 1 CD cord-329844-w969lczb 96 4 shows show VBZ cord-329844-w969lczb 96 5 the the DT cord-329844-w969lczb 96 6 external external JJ cord-329844-w969lczb 96 7 part part NN cord-329844-w969lczb 96 8 20 20 CD cord-329844-w969lczb 96 9 - - SYM cord-329844-w969lczb 96 10 1213 1213 CD cord-329844-w969lczb 96 11 of of IN cord-329844-w969lczb 96 12 the the DT cord-329844-w969lczb 96 13 spike spike NN cord-329844-w969lczb 96 14 glycoprotein glycoprotein NN cord-329844-w969lczb 96 15 of of IN cord-329844-w969lczb 96 16 SARS SARS NNP cord-329844-w969lczb 96 17 - - HYPH cord-329844-w969lczb 96 18 CoV-2 CoV-2 NNP cord-329844-w969lczb 96 19 in in IN cord-329844-w969lczb 96 20 the the DT cord-329844-w969lczb 96 21 closed closed JJ cord-329844-w969lczb 96 22 state state NN cord-329844-w969lczb 96 23 prior prior RB cord-329844-w969lczb 96 24 to to IN cord-329844-w969lczb 96 25 ACE2 ACE2 NNP cord-329844-w969lczb 96 26 binding binding NN cord-329844-w969lczb 96 27 , , , cord-329844-w969lczb 96 28 with with IN cord-329844-w969lczb 96 29 S1-NTD S1-NTD NNP cord-329844-w969lczb 96 30 domain domain NN cord-329844-w969lczb 96 31 ( ( -LRB- cord-329844-w969lczb 96 32 the the DT cord-329844-w969lczb 96 33 " " `` cord-329844-w969lczb 96 34 ears ear NNS cord-329844-w969lczb 96 35 " " '' cord-329844-w969lczb 96 36 , , , cord-329844-w969lczb 96 37 dark dark JJ cord-329844-w969lczb 96 38 blue blue JJ cord-329844-w969lczb 96 39 ) ) -RRB- cord-329844-w969lczb 96 40 of of IN cord-329844-w969lczb 96 41 interest interest NN cord-329844-w969lczb 96 42 here here RB cord-329844-w969lczb 96 43 , , , cord-329844-w969lczb 96 44 RBD RBD NNP cord-329844-w969lczb 96 45 ( ( -LRB- cord-329844-w969lczb 96 46 at at IN cord-329844-w969lczb 96 47 tip tip NN cord-329844-w969lczb 96 48 , , , cord-329844-w969lczb 96 49 subdomains subdomain NNS cord-329844-w969lczb 96 50 light light VBP cord-329844-w969lczb 96 51 blue blue JJ cord-329844-w969lczb 96 52 , , , cord-329844-w969lczb 96 53 blue blue JJ cord-329844-w969lczb 96 54 - - HYPH cord-329844-w969lczb 96 55 green green JJ cord-329844-w969lczb 96 56 ) ) -RRB- cord-329844-w969lczb 96 57 , , , cord-329844-w969lczb 96 58 S2 S2 NNP cord-329844-w969lczb 96 59 ( ( -LRB- cord-329844-w969lczb 96 60 subdomains subdomain NNS cord-329844-w969lczb 96 61 , , , cord-329844-w969lczb 96 62 orange orange JJ cord-329844-w969lczb 96 63 , , , cord-329844-w969lczb 96 64 green green JJ cord-329844-w969lczb 96 65 , , , cord-329844-w969lczb 96 66 yellow yellow JJ cord-329844-w969lczb 96 67 ) ) -RRB- cord-329844-w969lczb 96 68 . . . cord-329844-w969lczb 97 1 The the DT cord-329844-w969lczb 97 2 orange orange JJ cord-329844-w969lczb 97 3 - - HYPH cord-329844-w969lczb 97 4 white white JJ cord-329844-w969lczb 97 5 , , , cord-329844-w969lczb 97 6 green green JJ cord-329844-w969lczb 97 7 - - HYPH cord-329844-w969lczb 97 8 white white JJ cord-329844-w969lczb 97 9 and and CC cord-329844-w969lczb 97 10 yellow yellow JJ cord-329844-w969lczb 97 11 - - HYPH cord-329844-w969lczb 97 12 white white JJ cord-329844-w969lczb 97 13 helical helical JJ cord-329844-w969lczb 97 14 structures structure NNS cord-329844-w969lczb 97 15 are be VBP cord-329844-w969lczb 97 16 the the DT cord-329844-w969lczb 97 17 α α NN cord-329844-w969lczb 97 18 - - HYPH cord-329844-w969lczb 97 19 helices helix NNS cord-329844-w969lczb 97 20 of of IN cord-329844-w969lczb 97 21 the the DT cord-329844-w969lczb 97 22 trimer trimer NN cord-329844-w969lczb 97 23 that that WDT cord-329844-w969lczb 97 24 form form VBP cord-329844-w969lczb 97 25 the the DT cord-329844-w969lczb 97 26 neck neck NN cord-329844-w969lczb 97 27 associated associate VBN cord-329844-w969lczb 97 28 with with IN cord-329844-w969lczb 97 29 S2 S2 NNP cord-329844-w969lczb 97 30 , , , cord-329844-w969lczb 97 31 and and CC cord-329844-w969lczb 97 32 the the DT cord-329844-w969lczb 97 33 red red JJ cord-329844-w969lczb 97 34 - - HYPH cord-329844-w969lczb 97 35 white white JJ cord-329844-w969lczb 97 36 helical helical JJ cord-329844-w969lczb 97 37 structures structure NNS cord-329844-w969lczb 97 38 are be VBP cord-329844-w969lczb 97 39 the the DT cord-329844-w969lczb 97 40 start start NN cord-329844-w969lczb 97 41 of of IN cord-329844-w969lczb 97 42 the the DT cord-329844-w969lczb 97 43 transmembrane transmembrane NN cord-329844-w969lczb 97 44 α α NN cord-329844-w969lczb 97 45 - - HYPH cord-329844-w969lczb 97 46 helices helix NNS cord-329844-w969lczb 97 47 TM TM NNP cord-329844-w969lczb 97 48 . . . cord-329844-w969lczb 98 1 In in IN cord-329844-w969lczb 98 2 at at IN cord-329844-w969lczb 98 3 least least JJS cord-329844-w969lczb 98 4 some some DT cord-329844-w969lczb 98 5 coronaviruses coronaviruse NNS cord-329844-w969lczb 98 6 , , , cord-329844-w969lczb 98 7 S1-NTD S1-NTD NNP cord-329844-w969lczb 98 8 is be VBZ cord-329844-w969lczb 98 9 known know VBN cord-329844-w969lczb 98 10 to to TO cord-329844-w969lczb 98 11 be be VB cord-329844-w969lczb 98 12 involved involve VBN cord-329844-w969lczb 98 13 in in IN cord-329844-w969lczb 98 14 binding bind VBG cord-329844-w969lczb 98 15 host host NN cord-329844-w969lczb 98 16 proteins protein NNS cord-329844-w969lczb 98 17 or or CC cord-329844-w969lczb 98 18 glycans glycan NNS cord-329844-w969lczb 98 19 , , , cord-329844-w969lczb 98 20 but but CC cord-329844-w969lczb 98 21 coronaviruses coronaviruse NNS cord-329844-w969lczb 98 22 show show VBP cord-329844-w969lczb 98 23 great great JJ cord-329844-w969lczb 98 24 diversity diversity NN cord-329844-w969lczb 98 25 in in IN cord-329844-w969lczb 98 26 their -PRON- PRP$ cord-329844-w969lczb 98 27 binding binding NN cord-329844-w969lczb 98 28 which which WDT cord-329844-w969lczb 98 29 presumably presumably RB cord-329844-w969lczb 98 30 underlies underlie VBZ cord-329844-w969lczb 98 31 their -PRON- PRP$ cord-329844-w969lczb 98 32 ability ability NN cord-329844-w969lczb 98 33 to to TO cord-329844-w969lczb 98 34 jump jump VB cord-329844-w969lczb 98 35 between between IN cord-329844-w969lczb 98 36 very very RB cord-329844-w969lczb 98 37 different different JJ cord-329844-w969lczb 98 38 host host NN cord-329844-w969lczb 98 39 species specie NNS cord-329844-w969lczb 98 40 . . . cord-329844-w969lczb 99 1 While while IN cord-329844-w969lczb 99 2 the the DT cord-329844-w969lczb 99 3 role role NN cord-329844-w969lczb 99 4 of of IN cord-329844-w969lczb 99 5 S1-NTD S1-NTD NNP cord-329844-w969lczb 99 6 Compared compare VBN cord-329844-w969lczb 99 7 with with IN cord-329844-w969lczb 99 8 the the DT cord-329844-w969lczb 99 9 current current JJ cord-329844-w969lczb 99 10 reasonably reasonably RB cord-329844-w969lczb 99 11 detailed detailed JJ cord-329844-w969lczb 99 12 knowledge knowledge NN cord-329844-w969lczb 99 13 of of IN cord-329844-w969lczb 99 14 the the DT cord-329844-w969lczb 99 15 remarkable remarkable JJ cord-329844-w969lczb 99 16 mechanism mechanism NN cord-329844-w969lczb 99 17 of of IN cord-329844-w969lczb 99 18 cell cell NN cord-329844-w969lczb 99 19 entry entry NN cord-329844-w969lczb 99 20 involving involve VBG cord-329844-w969lczb 99 21 ACE2 ACE2 NNP cord-329844-w969lczb 99 22 and and CC cord-329844-w969lczb 99 23 changes change NNS cord-329844-w969lczb 99 24 to to IN cord-329844-w969lczb 99 25 the the DT cord-329844-w969lczb 99 26 spike spike NN cord-329844-w969lczb 99 27 protein protein NN cord-329844-w969lczb 99 28 on on IN cord-329844-w969lczb 99 29 cleavage cleavage NN cord-329844-w969lczb 99 30 , , , cord-329844-w969lczb 99 31 the the DT cord-329844-w969lczb 99 32 specific specific JJ cord-329844-w969lczb 99 33 function function NN cord-329844-w969lczb 99 34 of of IN cord-329844-w969lczb 99 35 S1-NTD S1-NTD NNP cord-329844-w969lczb 99 36 of of IN cord-329844-w969lczb 99 37 SARS SARS NNP cord-329844-w969lczb 99 38 - - HYPH cord-329844-w969lczb 99 39 CoV-2 CoV-2 NNP cord-329844-w969lczb 99 40 has have VBZ cord-329844-w969lczb 99 41 not not RB cord-329844-w969lczb 99 42 been be VBN cord-329844-w969lczb 99 43 elucidated elucidate VBN cord-329844-w969lczb 99 44 ( ( -LRB- cord-329844-w969lczb 99 45 at at IN cord-329844-w969lczb 99 46 least least JJS cord-329844-w969lczb 99 47 , , , cord-329844-w969lczb 99 48 not not RB cord-329844-w969lczb 99 49 by by IN cord-329844-w969lczb 99 50 the the DT cord-329844-w969lczb 99 51 time time NN cord-329844-w969lczb 99 52 of of IN cord-329844-w969lczb 99 53 writing writing NN cord-329844-w969lczb 99 54 in in IN cord-329844-w969lczb 99 55 April April NNP cord-329844-w969lczb 99 56 2020 2020 CD cord-329844-w969lczb 99 57 ) ) -RRB- cord-329844-w969lczb 99 58 . . . cord-329844-w969lczb 100 1 As as IN cord-329844-w969lczb 100 2 noted note VBN cord-329844-w969lczb 100 3 above above RB cord-329844-w969lczb 100 4 , , , cord-329844-w969lczb 100 5 S1 S1 NNP cord-329844-w969lczb 100 6 in in IN cord-329844-w969lczb 100 7 SARS SARS NNP cord-329844-w969lczb 100 8 - - HYPH cord-329844-w969lczb 100 9 CoV-2 CoV-2 NNP cord-329844-w969lczb 100 10 is be VBZ cord-329844-w969lczb 100 11 now now RB cord-329844-w969lczb 100 12 well well RB cord-329844-w969lczb 100 13 known known JJ cord-329844-w969lczb 100 14 to to TO cord-329844-w969lczb 100 15 have have VB cord-329844-w969lczb 100 16 a a DT cord-329844-w969lczb 100 17 region region NN cord-329844-w969lczb 100 18 which which WDT cord-329844-w969lczb 100 19 is be VBZ cord-329844-w969lczb 100 20 the the DT cord-329844-w969lczb 100 21 receptor receptor NN cord-329844-w969lczb 100 22 binding bind VBG cord-329844-w969lczb 100 23 domain domain NN cord-329844-w969lczb 100 24 to to IN cord-329844-w969lczb 100 25 human human JJ cord-329844-w969lczb 100 26 ACE2 ACE2 NNP cord-329844-w969lczb 100 27 but but CC cord-329844-w969lczb 100 28 also also RB cord-329844-w969lczb 100 29 , , , cord-329844-w969lczb 100 30 significantly significantly RB cord-329844-w969lczb 100 31 for for IN cord-329844-w969lczb 100 32 what what WP cord-329844-w969lczb 100 33 follows follow VBZ cord-329844-w969lczb 100 34 in in IN cord-329844-w969lczb 100 35 the the DT cord-329844-w969lczb 100 36 text text NN cord-329844-w969lczb 100 37 below below RB cord-329844-w969lczb 100 38 , , , cord-329844-w969lczb 100 39 SARS SARS NNP cord-329844-w969lczb 100 40 - - HYPH cord-329844-w969lczb 100 41 like like JJ cord-329844-w969lczb 100 42 coronaviruses coronaviruse NNS cord-329844-w969lczb 100 43 can can MD cord-329844-w969lczb 100 44 bind bind VB cord-329844-w969lczb 100 45 CLEC4M CLEC4M NNP cord-329844-w969lczb 100 46 / / SYM cord-329844-w969lczb 100 47 DC DC NNP cord-329844-w969lczb 100 48 - - HYPH cord-329844-w969lczb 100 49 SIGNR SIGNR NNP cord-329844-w969lczb 100 50 C c NN cord-329844-w969lczb 100 51 - - HYPH cord-329844-w969lczb 100 52 type type NN cord-329844-w969lczb 100 53 lectin lectin NN cord-329844-w969lczb 100 54 domains domain NNS cord-329844-w969lczb 100 55 on on IN cord-329844-w969lczb 100 56 host host NN cord-329844-w969lczb 100 57 cells cell NNS cord-329844-w969lczb 100 58 . . . cord-329844-w969lczb 101 1 See see VB cord-329844-w969lczb 101 2 Ref Ref NNP cord-329844-w969lczb 101 3 [ [ -LRB- cord-329844-w969lczb 101 4 12 12 CD cord-329844-w969lczb 101 5 ] ] -RRB- cord-329844-w969lczb 101 6 for for IN cord-329844-w969lczb 101 7 review review NN cord-329844-w969lczb 101 8 of of IN cord-329844-w969lczb 101 9 the the DT cord-329844-w969lczb 101 10 diverse diverse JJ cord-329844-w969lczb 101 11 receptor receptor NN cord-329844-w969lczb 101 12 recognition recognition NN cord-329844-w969lczb 101 13 mechanisms mechanism NNS cord-329844-w969lczb 101 14 of of IN cord-329844-w969lczb 101 15 coronaviruses coronaviruse NNS cord-329844-w969lczb 101 16 up up IN cord-329844-w969lczb 101 17 to to IN cord-329844-w969lczb 101 18 2015 2015 CD cord-329844-w969lczb 101 19 , , , cord-329844-w969lczb 101 20 which which WDT cord-329844-w969lczb 101 21 represented represent VBD cord-329844-w969lczb 101 22 the the DT cord-329844-w969lczb 101 23 body body NN cord-329844-w969lczb 101 24 of of IN cord-329844-w969lczb 101 25 understanding understanding NN cord-329844-w969lczb 101 26 until until IN cord-329844-w969lczb 101 27 the the DT cord-329844-w969lczb 101 28 COV-19 cov-19 JJ cord-329844-w969lczb 101 29 pandemic pandemic NN cord-329844-w969lczb 101 30 . . . cord-329844-w969lczb 102 1 Bovine bovine JJ cord-329844-w969lczb 102 2 coronavirus coronavirus NN cord-329844-w969lczb 102 3 is be VBZ cord-329844-w969lczb 102 4 an an DT cord-329844-w969lczb 102 5 example example NN cord-329844-w969lczb 102 6 of of IN cord-329844-w969lczb 102 7 a a DT cord-329844-w969lczb 102 8 coronavirus coronavirus NN cord-329844-w969lczb 102 9 for for IN cord-329844-w969lczb 102 10 which which WDT cord-329844-w969lczb 102 11 it -PRON- PRP cord-329844-w969lczb 102 12 seems seem VBZ cord-329844-w969lczb 102 13 clear clear JJ cord-329844-w969lczb 102 14 that that IN cord-329844-w969lczb 102 15 S1-NTD S1-NTD NNP cord-329844-w969lczb 102 16 has have VBZ cord-329844-w969lczb 102 17 an an DT cord-329844-w969lczb 102 18 established establish VBN cord-329844-w969lczb 102 19 glycan glycan NN cord-329844-w969lczb 102 20 - - HYPH cord-329844-w969lczb 102 21 binding bind VBG cord-329844-w969lczb 102 22 function function NN cord-329844-w969lczb 102 23 . . . cord-329844-w969lczb 103 1 Although although IN cord-329844-w969lczb 103 2 the the DT cord-329844-w969lczb 103 3 structure structure NN cord-329844-w969lczb 103 4 of of IN cord-329844-w969lczb 103 5 a a DT cord-329844-w969lczb 103 6 sugar sugar NN cord-329844-w969lczb 103 7 - - HYPH cord-329844-w969lczb 103 8 bound bind VBN cord-329844-w969lczb 103 9 Bovine bovine JJ cord-329844-w969lczb 103 10 CoV cov NN cord-329844-w969lczb 103 11 S1-NTD S1-NTD NNP cord-329844-w969lczb 103 12 was be VBD cord-329844-w969lczb 103 13 not not RB cord-329844-w969lczb 103 14 available available JJ cord-329844-w969lczb 103 15 , , , cord-329844-w969lczb 103 16 some some DT cord-329844-w969lczb 103 17 conclusions conclusion NNS cord-329844-w969lczb 103 18 could could MD cord-329844-w969lczb 103 19 be be VB cord-329844-w969lczb 103 20 reached reach VBN cord-329844-w969lczb 103 21 by by IN cord-329844-w969lczb 103 22 researchers researcher NNS cord-329844-w969lczb 103 23 using use VBG cord-329844-w969lczb 103 24 structureguided structureguided JJ cord-329844-w969lczb 103 25 mutagenesis mutagenesis NN cord-329844-w969lczb 103 26 and and CC cord-329844-w969lczb 103 27 comparisons comparison NNS cord-329844-w969lczb 103 28 with with IN cord-329844-w969lczb 103 29 different different JJ cord-329844-w969lczb 103 30 coronaviruses coronaviruse NNS cord-329844-w969lczb 103 31 . . . cord-329844-w969lczb 104 1 As as RB cord-329844-w969lczb 104 2 well well RB cord-329844-w969lczb 104 3 as as IN cord-329844-w969lczb 104 4 evidence evidence NN cord-329844-w969lczb 104 5 in in IN cord-329844-w969lczb 104 6 2008 2008 CD cord-329844-w969lczb 104 7 linking link VBG cord-329844-w969lczb 104 8 hemagglutinin hemagglutinin NN cord-329844-w969lczb 104 9 - - HYPH cord-329844-w969lczb 104 10 esterase esterase NN cord-329844-w969lczb 104 11 to to IN cord-329844-w969lczb 104 12 the the DT cord-329844-w969lczb 104 13 S1 S1 NNP cord-329844-w969lczb 104 14 domain domain NN cord-329844-w969lczb 104 15 of of IN cord-329844-w969lczb 104 16 at at IN cord-329844-w969lczb 104 17 least least JJS cord-329844-w969lczb 104 18 some some DT cord-329844-w969lczb 104 19 coronaviruses coronaviruse NNS cord-329844-w969lczb 104 20 [ [ -LRB- cord-329844-w969lczb 104 21 9 9 CD cord-329844-w969lczb 104 22 ] ] -RRB- cord-329844-w969lczb 104 23 , , , cord-329844-w969lczb 104 24 Zhang Zhang NNP cord-329844-w969lczb 104 25 and and CC cord-329844-w969lczb 104 26 Yap Yap NNP cord-329844-w969lczb 104 27 [ [ -LRB- cord-329844-w969lczb 104 28 13 13 CD cord-329844-w969lczb 104 29 ] ] -RRB- cord-329844-w969lczb 104 30 had have VBD cord-329844-w969lczb 104 31 reported report VBN cord-329844-w969lczb 104 32 in in IN cord-329844-w969lczb 104 33 2004 2004 CD cord-329844-w969lczb 104 34 a a DT cord-329844-w969lczb 104 35 rational rational JJ cord-329844-w969lczb 104 36 3D 3d JJ cord-329844-w969lczb 104 37 model model NN cord-329844-w969lczb 104 38 for for IN cord-329844-w969lczb 104 39 S1 s1 NN cord-329844-w969lczb 104 40 domain domain NN cord-329844-w969lczb 104 41 of of IN cord-329844-w969lczb 104 42 SARS SARS NNP cord-329844-w969lczb 104 43 - - HYPH cord-329844-w969lczb 104 44 CoV CoV NNP cord-329844-w969lczb 104 45 spike spike NN cord-329844-w969lczb 104 46 protein protein NN cord-329844-w969lczb 104 47 by by IN cord-329844-w969lczb 104 48 fold fold JJ cord-329844-w969lczb 104 49 recognition recognition NN cord-329844-w969lczb 104 50 and and CC cord-329844-w969lczb 104 51 molecular molecular JJ cord-329844-w969lczb 104 52 modeling modeling NN cord-329844-w969lczb 104 53 techniques technique NNS cord-329844-w969lczb 104 54 , , , cord-329844-w969lczb 104 55 and and CC cord-329844-w969lczb 104 56 there there RB cord-329844-w969lczb 104 57 they -PRON- PRP cord-329844-w969lczb 104 58 noted note VBD cord-329844-w969lczb 104 59 a a DT cord-329844-w969lczb 104 60 suggestive suggestive JJ cord-329844-w969lczb 104 61 structure structure NN cord-329844-w969lczb 104 62 similarity similarity NN cord-329844-w969lczb 104 63 between between IN cord-329844-w969lczb 104 64 S1 s1 NN cord-329844-w969lczb 104 65 protein protein NN cord-329844-w969lczb 104 66 and and CC cord-329844-w969lczb 104 67 influenza influenza NN cord-329844-w969lczb 104 68 virus virus NN cord-329844-w969lczb 104 69 neuraminidase neuraminidase NN cord-329844-w969lczb 104 70 [ [ -LRB- cord-329844-w969lczb 104 71 14 14 CD cord-329844-w969lczb 104 72 ] ] -RRB- cord-329844-w969lczb 104 73 . . . cord-329844-w969lczb 105 1 This this DT cord-329844-w969lczb 105 2 opened open VBD cord-329844-w969lczb 105 3 up up RP cord-329844-w969lczb 105 4 the the DT cord-329844-w969lczb 105 5 possibility possibility NN cord-329844-w969lczb 105 6 for for IN cord-329844-w969lczb 105 7 those those DT cord-329844-w969lczb 105 8 authors author NNS cord-329844-w969lczb 105 9 that that IN cord-329844-w969lczb 105 10 existing exist VBG cord-329844-w969lczb 105 11 antiinfluenza antiinfluenza NNP cord-329844-w969lczb 105 12 virus virus NN cord-329844-w969lczb 105 13 inhibitors inhibitor NNS cord-329844-w969lczb 105 14 and and CC cord-329844-w969lczb 105 15 anti anti JJ cord-329844-w969lczb 105 16 - - JJ cord-329844-w969lczb 105 17 neuraminidase neuraminidase JJ cord-329844-w969lczb 105 18 antibody antibody NN cord-329844-w969lczb 105 19 could could MD cord-329844-w969lczb 105 20 be be VB cord-329844-w969lczb 105 21 used use VBN cord-329844-w969lczb 105 22 as as IN cord-329844-w969lczb 105 23 a a DT cord-329844-w969lczb 105 24 starting starting NN cord-329844-w969lczb 105 25 point point NN cord-329844-w969lczb 105 26 for for IN cord-329844-w969lczb 105 27 designing design VBG cord-329844-w969lczb 105 28 anti anti JJ cord-329844-w969lczb 105 29 - - JJ cord-329844-w969lczb 105 30 SARS SARS NNP cord-329844-w969lczb 105 31 drugs drug NNS cord-329844-w969lczb 105 32 , , , cord-329844-w969lczb 105 33 vaccines vaccine NNS cord-329844-w969lczb 105 34 and and CC cord-329844-w969lczb 105 35 antibodies antibody NNS cord-329844-w969lczb 105 36 [ [ -LRB- cord-329844-w969lczb 105 37 14 14 CD cord-329844-w969lczb 105 38 ] ] -RRB- cord-329844-w969lczb 105 39 . . . cord-329844-w969lczb 106 1 Based base VBN cord-329844-w969lczb 106 2 on on IN cord-329844-w969lczb 106 3 such such JJ cord-329844-w969lczb 106 4 observations observation NNS cord-329844-w969lczb 106 5 and and CC cord-329844-w969lczb 106 6 discussion discussion NN cord-329844-w969lczb 106 7 so so RB cord-329844-w969lczb 106 8 far far RB cord-329844-w969lczb 106 9 , , , cord-329844-w969lczb 106 10 it -PRON- PRP cord-329844-w969lczb 106 11 is be VBZ cord-329844-w969lczb 106 12 therefore therefore RB cord-329844-w969lczb 106 13 reasonable reasonable JJ cord-329844-w969lczb 106 14 to to TO cord-329844-w969lczb 106 15 propose propose VB cord-329844-w969lczb 106 16 that that IN cord-329844-w969lczb 106 17 S1-NTD S1-NTD NNP cord-329844-w969lczb 106 18 could could MD cord-329844-w969lczb 106 19 be be VB cord-329844-w969lczb 106 20 important important JJ cord-329844-w969lczb 106 21 in in IN cord-329844-w969lczb 106 22 the the DT cord-329844-w969lczb 106 23 binding binding NN cord-329844-w969lczb 106 24 of of IN cord-329844-w969lczb 106 25 certain certain JJ cord-329844-w969lczb 106 26 alternative alternative JJ cord-329844-w969lczb 106 27 host host NN cord-329844-w969lczb 106 28 cell cell NN cord-329844-w969lczb 106 29 surface surface NN cord-329844-w969lczb 106 30 receptors receptor NNS cord-329844-w969lczb 106 31 , , , cord-329844-w969lczb 106 32 or or CC cord-329844-w969lczb 106 33 perhaps perhaps RB cord-329844-w969lczb 106 34 which which WDT cord-329844-w969lczb 106 35 aid aid NN cord-329844-w969lczb 106 36 in in IN cord-329844-w969lczb 106 37 targeting target VBG cord-329844-w969lczb 106 38 the the DT cord-329844-w969lczb 106 39 virus virus NN cord-329844-w969lczb 106 40 to to IN cord-329844-w969lczb 106 41 ACE2 ACE2 NNP cord-329844-w969lczb 106 42 , , , cord-329844-w969lczb 106 43 and and CC cord-329844-w969lczb 106 44 so so RB cord-329844-w969lczb 106 45 might may MD cord-329844-w969lczb 106 46 provide provide VB cord-329844-w969lczb 106 47 a a DT cord-329844-w969lczb 106 48 helpful helpful JJ cord-329844-w969lczb 106 49 therapeutic therapeutic JJ cord-329844-w969lczb 106 50 target target NN cord-329844-w969lczb 106 51 ( ( -LRB- cord-329844-w969lczb 106 52 as as RB cord-329844-w969lczb 106 53 well well RB cord-329844-w969lczb 106 54 as as IN cord-329844-w969lczb 106 55 candidate candidate NN cord-329844-w969lczb 106 56 antigenic antigenic JJ cord-329844-w969lczb 106 57 site site NN cord-329844-w969lczb 106 58 for for IN cord-329844-w969lczb 106 59 synthetic synthetic JJ cord-329844-w969lczb 106 60 vaccine vaccine NN cord-329844-w969lczb 106 61 design design NN cord-329844-w969lczb 106 62 ) ) -RRB- cord-329844-w969lczb 106 63 . . . cord-329844-w969lczb 107 1 Nonetheless nonetheless RB cord-329844-w969lczb 107 2 , , , cord-329844-w969lczb 107 3 such such JJ cord-329844-w969lczb 107 4 functions function NNS cord-329844-w969lczb 107 5 if if IN cord-329844-w969lczb 107 6 present present JJ cord-329844-w969lczb 107 7 in in IN cord-329844-w969lczb 107 8 SARS SARS NNP cord-329844-w969lczb 107 9 - - HYPH cord-329844-w969lczb 107 10 CoV-2 CoV-2 NNP cord-329844-w969lczb 107 11 could could MD cord-329844-w969lczb 107 12 , , , cord-329844-w969lczb 107 13 a a FW cord-329844-w969lczb 107 14 priori priori FW cord-329844-w969lczb 107 15 , , , cord-329844-w969lczb 107 16 reside reside VB cord-329844-w969lczb 107 17 in in IN cord-329844-w969lczb 107 18 other other JJ cord-329844-w969lczb 107 19 domains domain NNS cord-329844-w969lczb 107 20 at at IN cord-329844-w969lczb 107 21 the the DT cord-329844-w969lczb 107 22 virus virus NN cord-329844-w969lczb 107 23 surface surface NN cord-329844-w969lczb 107 24 . . . cord-329844-w969lczb 108 1 The the DT cord-329844-w969lczb 108 2 challenge challenge NN cord-329844-w969lczb 108 3 for for IN cord-329844-w969lczb 108 4 research research NN cord-329844-w969lczb 108 5 here here RB cord-329844-w969lczb 108 6 is be VBZ cord-329844-w969lczb 108 7 that that IN cord-329844-w969lczb 108 8 the the DT cord-329844-w969lczb 108 9 substantial substantial JJ cord-329844-w969lczb 108 10 knowledge knowledge NN cord-329844-w969lczb 108 11 concerning concern VBG cord-329844-w969lczb 108 12 such such JJ cord-329844-w969lczb 108 13 matters matter NNS cord-329844-w969lczb 108 14 in in IN cord-329844-w969lczb 108 15 well well RB cord-329844-w969lczb 108 16 - - HYPH cord-329844-w969lczb 108 17 studied study VBN cord-329844-w969lczb 108 18 coronaviruses coronaviruse NNS cord-329844-w969lczb 108 19 is be VBZ cord-329844-w969lczb 108 20 not not RB cord-329844-w969lczb 108 21 readily readily RB cord-329844-w969lczb 108 22 transferable transferable JJ cord-329844-w969lczb 108 23 . . . cord-329844-w969lczb 109 1 Variously variously RB cord-329844-w969lczb 109 2 throughout throughout IN cord-329844-w969lczb 109 3 the the DT cord-329844-w969lczb 109 4 coronaviruses coronaviruse NNS cord-329844-w969lczb 109 5 , , , cord-329844-w969lczb 109 6 S1-NTD S1-NTD NNP cord-329844-w969lczb 109 7 , , , cord-329844-w969lczb 109 8 CTD CTD NNP cord-329844-w969lczb 109 9 and and CC cord-329844-w969lczb 109 10 S2 s2 NN cord-329844-w969lczb 109 11 regions region NNS cord-329844-w969lczb 109 12 can can MD cord-329844-w969lczb 109 13 recognize recognize VB cord-329844-w969lczb 109 14 either either CC cord-329844-w969lczb 109 15 protein protein NN cord-329844-w969lczb 109 16 or or CC cord-329844-w969lczb 109 17 sugar sugar NN cord-329844-w969lczb 109 18 receptors receptor NNS cord-329844-w969lczb 109 19 or or CC cord-329844-w969lczb 109 20 both both DT cord-329844-w969lczb 109 21 in in IN cord-329844-w969lczb 109 22 various various JJ cord-329844-w969lczb 109 23 cases case NNS cord-329844-w969lczb 109 24 , , , cord-329844-w969lczb 109 25 and and CC cord-329844-w969lczb 109 26 very very RB cord-329844-w969lczb 109 27 similar similar JJ cord-329844-w969lczb 109 28 coronavirus coronavirus NN cord-329844-w969lczb 109 29 spike spike NN cord-329844-w969lczb 109 30 protein protein NN cord-329844-w969lczb 109 31 domains domain NNS cord-329844-w969lczb 109 32 within within IN cord-329844-w969lczb 109 33 the the DT cord-329844-w969lczb 109 34 same same JJ cord-329844-w969lczb 109 35 genus genus NN cord-329844-w969lczb 109 36 may may MD cord-329844-w969lczb 109 37 recognize recognize VB cord-329844-w969lczb 109 38 different different JJ cord-329844-w969lczb 109 39 host host NN cord-329844-w969lczb 109 40 cell cell NN cord-329844-w969lczb 109 41 receptors receptor NNS cord-329844-w969lczb 109 42 , , , cord-329844-w969lczb 109 43 while while IN cord-329844-w969lczb 109 44 many many JJ cord-329844-w969lczb 109 45 very very RB cord-329844-w969lczb 109 46 different different JJ cord-329844-w969lczb 109 47 coronaviruses coronaviruse NNS cord-329844-w969lczb 109 48 may may MD cord-329844-w969lczb 109 49 recognize recognize VB cord-329844-w969lczb 109 50 the the DT cord-329844-w969lczb 109 51 same same JJ cord-329844-w969lczb 109 52 host host NN cord-329844-w969lczb 109 53 cell cell NN cord-329844-w969lczb 109 54 receptor receptor NN cord-329844-w969lczb 109 55 . . . cord-329844-w969lczb 110 1 The the DT cord-329844-w969lczb 110 2 studies study NNS cord-329844-w969lczb 110 3 mentioned mention VBN cord-329844-w969lczb 110 4 above above RB cord-329844-w969lczb 110 5 also also RB cord-329844-w969lczb 110 6 suggested suggest VBD cord-329844-w969lczb 110 7 that that IN cord-329844-w969lczb 110 8 at at IN cord-329844-w969lczb 110 9 least least JJS cord-329844-w969lczb 110 10 some some DT cord-329844-w969lczb 110 11 coronavirus coronavirus NN cord-329844-w969lczb 110 12 S1-NTDs s1-ntds CD cord-329844-w969lczb 110 13 are be VBP cord-329844-w969lczb 110 14 evolutionarily evolutionarily RB cord-329844-w969lczb 110 15 related related JJ cord-329844-w969lczb 110 16 to to IN cord-329844-w969lczb 110 17 human human JJ cord-329844-w969lczb 110 18 galectins galectin NNS cord-329844-w969lczb 110 19 , , , cord-329844-w969lczb 110 20 the the DT cord-329844-w969lczb 110 21 term term NN cord-329844-w969lczb 110 22 typically typically RB cord-329844-w969lczb 110 23 used use VBN cord-329844-w969lczb 110 24 for for IN cord-329844-w969lczb 110 25 the the DT cord-329844-w969lczb 110 26 lectins lectin NNS cord-329844-w969lczb 110 27 as as IN cord-329844-w969lczb 110 28 carbohydrate carbohydrate NN cord-329844-w969lczb 110 29 - - HYPH cord-329844-w969lczb 110 30 binding bind VBG cord-329844-w969lczb 110 31 proteins protein NNS cord-329844-w969lczb 110 32 that that WDT cord-329844-w969lczb 110 33 are be VBP cord-329844-w969lczb 110 34 specifically specifically RB cord-329844-w969lczb 110 35 involved involve VBN cord-329844-w969lczb 110 36 in in IN cord-329844-w969lczb 110 37 inflammation inflammation NN cord-329844-w969lczb 110 38 , , , cord-329844-w969lczb 110 39 immune immune JJ cord-329844-w969lczb 110 40 responses response NNS cord-329844-w969lczb 110 41 , , , cord-329844-w969lczb 110 42 cell cell NN cord-329844-w969lczb 110 43 migration migration NN cord-329844-w969lczb 110 44 , , , cord-329844-w969lczb 110 45 autophagy autophagy NN cord-329844-w969lczb 110 46 and and CC cord-329844-w969lczb 110 47 signaling signaling NN cord-329844-w969lczb 110 48 ; ; : cord-329844-w969lczb 110 49 however however RB cord-329844-w969lczb 110 50 the the DT cord-329844-w969lczb 110 51 viral viral JJ cord-329844-w969lczb 110 52 domains domain NNS cord-329844-w969lczb 110 53 derived derive VBN cord-329844-w969lczb 110 54 from from IN cord-329844-w969lczb 110 55 them -PRON- PRP cord-329844-w969lczb 110 56 have have VBP cord-329844-w969lczb 110 57 diverged diverge VBN cord-329844-w969lczb 110 58 with with IN cord-329844-w969lczb 110 59 specificities specificity NNS cord-329844-w969lczb 110 60 for for IN cord-329844-w969lczb 110 61 different different JJ cord-329844-w969lczb 110 62 sugar sugar NN cord-329844-w969lczb 110 63 receptors receptor NNS cord-329844-w969lczb 110 64 [ [ -LRB- cord-329844-w969lczb 110 65 12 12 CD cord-329844-w969lczb 110 66 ] ] -RRB- cord-329844-w969lczb 110 67 . . . cord-329844-w969lczb 111 1 Further further JJ cord-329844-w969lczb 111 2 review review NN cord-329844-w969lczb 111 3 is be VBZ cord-329844-w969lczb 111 4 given give VBN cord-329844-w969lczb 111 5 throughout throughout IN cord-329844-w969lczb 111 6 Results Results NNP cord-329844-w969lczb 111 7 Section Section NNP cord-329844-w969lczb 111 8 4 4 CD cord-329844-w969lczb 111 9 where where WRB cord-329844-w969lczb 111 10 appropriate appropriate JJ cord-329844-w969lczb 111 11 . . . cord-329844-w969lczb 112 1 Another another DT cord-329844-w969lczb 112 2 challenge challenge NN cord-329844-w969lczb 112 3 discussed discuss VBN cord-329844-w969lczb 112 4 in in IN cord-329844-w969lczb 112 5 Results Results NNP cord-329844-w969lczb 112 6 Section Section NNP cord-329844-w969lczb 112 7 4 4 CD cord-329844-w969lczb 112 8 is be VBZ cord-329844-w969lczb 112 9 that that IN cord-329844-w969lczb 112 10 key key JJ cord-329844-w969lczb 112 11 regions region NNS cord-329844-w969lczb 112 12 for for IN cord-329844-w969lczb 112 13 which which WDT cord-329844-w969lczb 112 14 an an DT cord-329844-w969lczb 112 15 experimental experimental JJ cord-329844-w969lczb 112 16 3D 3d JJ cord-329844-w969lczb 112 17 structure structure NN cord-329844-w969lczb 112 18 would would MD cord-329844-w969lczb 112 19 help help VB cord-329844-w969lczb 112 20 resolve resolve VB cord-329844-w969lczb 112 21 the the DT cord-329844-w969lczb 112 22 matter matter NN cord-329844-w969lczb 112 23 are be VBP cord-329844-w969lczb 112 24 disordered disordered JJ cord-329844-w969lczb 112 25 , , , cord-329844-w969lczb 112 26 and and CC cord-329844-w969lczb 112 27 hence hence RB cord-329844-w969lczb 112 28 invisible invisible JJ cord-329844-w969lczb 112 29 , , , cord-329844-w969lczb 112 30 in in IN cord-329844-w969lczb 112 31 current current JJ cord-329844-w969lczb 112 32 available available JJ cord-329844-w969lczb 112 33 spike spike NN cord-329844-w969lczb 112 34 protein protein NN cord-329844-w969lczb 112 35 structures structure NNS cord-329844-w969lczb 112 36 . . . cord-329844-w969lczb 113 1 Less less RBR cord-329844-w969lczb 113 2 familiar familiar JJ cord-329844-w969lczb 113 3 theoretical theoretical JJ cord-329844-w969lczb 113 4 principles principle NNS cord-329844-w969lczb 113 5 do do VBP cord-329844-w969lczb 113 6 arise arise VB cord-329844-w969lczb 113 7 in in IN cord-329844-w969lczb 113 8 the the DT cord-329844-w969lczb 113 9 knowledge knowledge NN cord-329844-w969lczb 113 10 gathering gathering NN cord-329844-w969lczb 113 11 , , , cord-329844-w969lczb 113 12 inference inference NN cord-329844-w969lczb 113 13 , , , cord-329844-w969lczb 113 14 and and CC cord-329844-w969lczb 113 15 prediction prediction NN cord-329844-w969lczb 113 16 methods method NNS cord-329844-w969lczb 113 17 developed develop VBN cord-329844-w969lczb 113 18 by by IN cord-329844-w969lczb 113 19 the the DT cord-329844-w969lczb 113 20 author author NN cord-329844-w969lczb 113 21 and and CC cord-329844-w969lczb 113 22 colleagues colleague NNS cord-329844-w969lczb 113 23 are be VBP cord-329844-w969lczb 113 24 used use VBN cord-329844-w969lczb 113 25 in in IN cord-329844-w969lczb 113 26 the the DT cord-329844-w969lczb 113 27 present present JJ cord-329844-w969lczb 113 28 COV-19 cov-19 JJ cord-329844-w969lczb 113 29 project project NN cord-329844-w969lczb 113 30 as as IN cord-329844-w969lczb 113 31 described describe VBN cord-329844-w969lczb 113 32 in in IN cord-329844-w969lczb 113 33 Ref Ref NNP cord-329844-w969lczb 113 34 [ [ -LRB- cord-329844-w969lczb 113 35 4 4 CD cord-329844-w969lczb 113 36 ] ] -RRB- cord-329844-w969lczb 113 37 . . . cord-329844-w969lczb 114 1 They -PRON- PRP cord-329844-w969lczb 114 2 also also RB cord-329844-w969lczb 114 3 include include VBP cord-329844-w969lczb 114 4 approaches approach NNS cord-329844-w969lczb 114 5 to to TO cord-329844-w969lczb 114 6 facilitate facilitate VB cord-329844-w969lczb 114 7 interaction interaction NN cord-329844-w969lczb 114 8 with with IN cord-329844-w969lczb 114 9 the the DT cord-329844-w969lczb 114 10 standard standard JJ cord-329844-w969lczb 114 11 bioinformatics bioinformatic NNS cord-329844-w969lczb 114 12 web web NN cord-329844-w969lczb 114 13 tools tool NNS cord-329844-w969lczb 114 14 which which WDT cord-329844-w969lczb 114 15 are be VBP cord-329844-w969lczb 114 16 stated state VBN cord-329844-w969lczb 114 17 below below IN cord-329844-w969lczb 114 18 in in IN cord-329844-w969lczb 114 19 Methods Methods NNPS cord-329844-w969lczb 114 20 Section Section NNP cord-329844-w969lczb 114 21 3 3 CD cord-329844-w969lczb 114 22 . . . cord-329844-w969lczb 115 1 However however RB cord-329844-w969lczb 115 2 , , , cord-329844-w969lczb 115 3 while while IN cord-329844-w969lczb 115 4 tools tool NNS cord-329844-w969lczb 115 5 of of IN cord-329844-w969lczb 115 6 these these DT cord-329844-w969lczb 115 7 various various JJ cord-329844-w969lczb 115 8 kinds kind NNS cord-329844-w969lczb 115 9 do do VBP cord-329844-w969lczb 115 10 speed speed VB cord-329844-w969lczb 115 11 and and CC cord-329844-w969lczb 115 12 facilitate facilitate VB cord-329844-w969lczb 115 13 a a DT cord-329844-w969lczb 115 14 project project NN cord-329844-w969lczb 115 15 of of IN cord-329844-w969lczb 115 16 this this DT cord-329844-w969lczb 115 17 nature nature NN cord-329844-w969lczb 115 18 , , , cord-329844-w969lczb 115 19 the the DT cord-329844-w969lczb 115 20 usual usual JJ cord-329844-w969lczb 115 21 methods method NNS cord-329844-w969lczb 115 22 of of IN cord-329844-w969lczb 115 23 investigating investigate VBG cord-329844-w969lczb 115 24 literature literature NN cord-329844-w969lczb 115 25 and and CC cord-329844-w969lczb 115 26 accessing access VBG cord-329844-w969lczb 115 27 bioinformatics bioinformatics NN cord-329844-w969lczb 115 28 data data NN cord-329844-w969lczb 115 29 bases basis NNS cord-329844-w969lczb 115 30 and and CC cord-329844-w969lczb 115 31 tool tool NN cord-329844-w969lczb 115 32 are be VBP cord-329844-w969lczb 115 33 sufficient sufficient JJ cord-329844-w969lczb 115 34 for for IN cord-329844-w969lczb 115 35 reproducibility reproducibility NN cord-329844-w969lczb 115 36 of of IN cord-329844-w969lczb 115 37 the the DT cord-329844-w969lczb 115 38 work work NN cord-329844-w969lczb 115 39 described describe VBN cord-329844-w969lczb 115 40 in in IN cord-329844-w969lczb 115 41 this this DT cord-329844-w969lczb 115 42 paper paper NN cord-329844-w969lczb 115 43 , , , cord-329844-w969lczb 115 44 at at IN cord-329844-w969lczb 115 45 least least JJS cord-329844-w969lczb 115 46 by by IN cord-329844-w969lczb 115 47 researchers researcher NNS cord-329844-w969lczb 115 48 reasonably reasonably RB cord-329844-w969lczb 115 49 familiar familiar JJ cord-329844-w969lczb 115 50 with with IN cord-329844-w969lczb 115 51 bioinformatics bioinformatic NNS cord-329844-w969lczb 115 52 and and CC cord-329844-w969lczb 115 53 protein protein NN cord-329844-w969lczb 115 54 structure structure NN cord-329844-w969lczb 115 55 . . . cord-329844-w969lczb 116 1 An an DT cord-329844-w969lczb 116 2 algorithm algorithm NN cord-329844-w969lczb 116 3 for for IN cord-329844-w969lczb 116 4 predicting predict VBG cord-329844-w969lczb 116 5 the the DT cord-329844-w969lczb 116 6 domains domain NNS cord-329844-w969lczb 116 7 and and CC cord-329844-w969lczb 116 8 proteins protein NNS cord-329844-w969lczb 116 9 involved involve VBN cord-329844-w969lczb 116 10 in in IN cord-329844-w969lczb 116 11 sialic sialic JJ cord-329844-w969lczb 116 12 acid acid NN cord-329844-w969lczb 116 13 glycan glycan NN cord-329844-w969lczb 116 14 binding binding NN cord-329844-w969lczb 116 15 is be VBZ cord-329844-w969lczb 116 16 developed develop VBN cord-329844-w969lczb 116 17 in in IN cord-329844-w969lczb 116 18 the the DT cord-329844-w969lczb 116 19 course course NN cord-329844-w969lczb 116 20 of of IN cord-329844-w969lczb 116 21 the the DT cord-329844-w969lczb 116 22 project project NN cord-329844-w969lczb 116 23 described describe VBN cord-329844-w969lczb 116 24 in in IN cord-329844-w969lczb 116 25 Results Results NNP cord-329844-w969lczb 116 26 Section Section NNP cord-329844-w969lczb 116 27 4 4 CD cord-329844-w969lczb 116 28 , , , cord-329844-w969lczb 116 29 but but CC cord-329844-w969lczb 116 30 this this DT cord-329844-w969lczb 116 31 is be VBZ cord-329844-w969lczb 116 32 primarily primarily RB cord-329844-w969lczb 116 33 of of IN cord-329844-w969lczb 116 34 a a DT cord-329844-w969lczb 116 35 highly highly RB cord-329844-w969lczb 116 36 empirical empirical JJ cord-329844-w969lczb 116 37 nature nature NN cord-329844-w969lczb 116 38 . . . cord-329844-w969lczb 117 1 Future future JJ cord-329844-w969lczb 117 2 work work NN cord-329844-w969lczb 117 3 to to TO cord-329844-w969lczb 117 4 advance advance VB cord-329844-w969lczb 117 5 this this DT cord-329844-w969lczb 117 6 algorithm algorithm NN cord-329844-w969lczb 117 7 on on IN cord-329844-w969lczb 117 8 a a DT cord-329844-w969lczb 117 9 sounder sound JJR cord-329844-w969lczb 117 10 theoretical theoretical JJ cord-329844-w969lczb 117 11 basis basis NN cord-329844-w969lczb 117 12 is be VBZ cord-329844-w969lczb 117 13 underway underway JJ cord-329844-w969lczb 117 14 . . . cord-329844-w969lczb 118 1 See see VB cord-329844-w969lczb 118 2 brief brief JJ cord-329844-w969lczb 118 3 discussion discussion NN cord-329844-w969lczb 118 4 on on IN cord-329844-w969lczb 118 5 future future JJ cord-329844-w969lczb 118 6 work work NN cord-329844-w969lczb 118 7 in in IN cord-329844-w969lczb 118 8 Discussion Discussion NNP cord-329844-w969lczb 118 9 Section Section NNP cord-329844-w969lczb 118 10 5.1 5.1 CD cord-329844-w969lczb 118 11 , , , cord-329844-w969lczb 118 12 where where WRB cord-329844-w969lczb 118 13 some some DT cord-329844-w969lczb 118 14 of of IN cord-329844-w969lczb 118 15 the the DT cord-329844-w969lczb 118 16 above above RB cord-329844-w969lczb 118 17 - - HYPH cord-329844-w969lczb 118 18 mentioned mention VBN cord-329844-w969lczb 118 19 theoretical theoretical JJ cord-329844-w969lczb 118 20 approaches approach NNS cord-329844-w969lczb 118 21 of of IN cord-329844-w969lczb 118 22 the the DT cord-329844-w969lczb 118 23 author author NN cord-329844-w969lczb 118 24 and and CC cord-329844-w969lczb 118 25 colleagues colleague NNS cord-329844-w969lczb 118 26 , , , cord-329844-w969lczb 118 27 also also RB cord-329844-w969lczb 118 28 to to TO cord-329844-w969lczb 118 29 be be VB cord-329844-w969lczb 118 30 used use VBN cord-329844-w969lczb 118 31 in in IN cord-329844-w969lczb 118 32 the the DT cord-329844-w969lczb 118 33 development development NN cord-329844-w969lczb 118 34 of of IN cord-329844-w969lczb 118 35 the the DT cord-329844-w969lczb 118 36 algorithm algorithm NN cord-329844-w969lczb 118 37 , , , cord-329844-w969lczb 118 38 are be VBP cord-329844-w969lczb 118 39 cited cite VBN cord-329844-w969lczb 118 40 . . . cord-329844-w969lczb 119 1 The the DT cord-329844-w969lczb 119 2 overall overall JJ cord-329844-w969lczb 119 3 approach approach NN cord-329844-w969lczb 119 4 comprised comprise VBD cord-329844-w969lczb 119 5 the the DT cord-329844-w969lczb 119 6 following follow VBG cord-329844-w969lczb 119 7 steps step NNS cord-329844-w969lczb 119 8 . . . cord-329844-w969lczb 120 1 i. i. NNP cord-329844-w969lczb 120 2 Automated automate VBN cord-329844-w969lczb 120 3 gathering gathering NN cord-329844-w969lczb 120 4 of of IN cord-329844-w969lczb 120 5 information information NN cord-329844-w969lczb 120 6 from from IN cord-329844-w969lczb 120 7 the the DT cord-329844-w969lczb 120 8 World World NNP cord-329844-w969lczb 120 9 Wide Wide NNP cord-329844-w969lczb 120 10 Web Web NNP cord-329844-w969lczb 120 11 regarding regard VBG cord-329844-w969lczb 120 12 hemagglutinins hemagglutinin NNS cord-329844-w969lczb 120 13 , , , cord-329844-w969lczb 120 14 neuraminidases neuraminidases NNP cord-329844-w969lczb 120 15 , , , cord-329844-w969lczb 120 16 and and CC cord-329844-w969lczb 120 17 sugar sugar NN cord-329844-w969lczb 120 18 binding binding NN cord-329844-w969lczb 120 19 proteins protein NNS cord-329844-w969lczb 120 20 , , , cord-329844-w969lczb 120 21 particularly particularly RB cord-329844-w969lczb 120 22 but but CC cord-329844-w969lczb 120 23 not not RB cord-329844-w969lczb 120 24 solely solely RB cord-329844-w969lczb 120 25 of of IN cord-329844-w969lczb 120 26 viruses virus NNS cord-329844-w969lczb 120 27 , , , cord-329844-w969lczb 120 28 using use VBG cord-329844-w969lczb 120 29 " " `` cord-329844-w969lczb 120 30 autosurfing autosurfe VBG cord-329844-w969lczb 120 31 " " '' cord-329844-w969lczb 120 32 , , , cord-329844-w969lczb 120 33 natural natural JJ cord-329844-w969lczb 120 34 language language NN cord-329844-w969lczb 120 35 processing processing NN cord-329844-w969lczb 120 36 , , , cord-329844-w969lczb 120 37 and and CC cord-329844-w969lczb 120 38 knowledge knowledge NN cord-329844-w969lczb 120 39 extraction extraction NN cord-329844-w969lczb 120 40 techniques technique NNS cord-329844-w969lczb 120 41 [ [ -LRB- cord-329844-w969lczb 120 42 4 4 CD cord-329844-w969lczb 120 43 ] ] -RRB- cord-329844-w969lczb 120 44 . . . cord-329844-w969lczb 121 1 Note note VB cord-329844-w969lczb 121 2 that that IN cord-329844-w969lczb 121 3 it -PRON- PRP cord-329844-w969lczb 121 4 is be VBZ cord-329844-w969lczb 121 5 in in IN cord-329844-w969lczb 121 6 particular particular JJ cord-329844-w969lczb 121 7 non non JJ cord-329844-w969lczb 121 8 - - JJ cord-329844-w969lczb 121 9 covalent covalent JJ cord-329844-w969lczb 121 10 sialic sialic NN cord-329844-w969lczb 121 11 acid acid NN cord-329844-w969lczb 121 12 glycan glycan NN cord-329844-w969lczb 121 13 binding bind VBG cord-329844-w969lczb 121 14 sites site NNS cord-329844-w969lczb 121 15 that that WDT cord-329844-w969lczb 121 16 are be VBP cord-329844-w969lczb 121 17 being be VBG cord-329844-w969lczb 121 18 explored explore VBN cord-329844-w969lczb 121 19 , , , cord-329844-w969lczb 121 20 not not RB cord-329844-w969lczb 121 21 for for IN cord-329844-w969lczb 121 22 example example NN cord-329844-w969lczb 121 23 asparagine asparagine NN cord-329844-w969lczb 121 24 or or CC cord-329844-w969lczb 121 25 serine serine NN cord-329844-w969lczb 121 26 or or CC cord-329844-w969lczb 121 27 threonine threonine NN cord-329844-w969lczb 121 28 sites site NNS cord-329844-w969lczb 121 29 to to TO cord-329844-w969lczb 121 30 which which WDT cord-329844-w969lczb 121 31 glycans glycan NNS cord-329844-w969lczb 121 32 are be VBP cord-329844-w969lczb 121 33 covalently covalently RB cord-329844-w969lczb 121 34 linked link VBN cord-329844-w969lczb 121 35 . . . cord-329844-w969lczb 122 1 This this DT cord-329844-w969lczb 122 2 knowledge knowledge NN cord-329844-w969lczb 122 3 gathering gathering NN cord-329844-w969lczb 122 4 approach approach NN cord-329844-w969lczb 122 5 , , , cord-329844-w969lczb 122 6 as as IN cord-329844-w969lczb 122 7 described describe VBN cord-329844-w969lczb 122 8 in in IN cord-329844-w969lczb 122 9 ref ref NN cord-329844-w969lczb 122 10 [ [ -LRB- cord-329844-w969lczb 122 11 4 4 CD cord-329844-w969lczb 122 12 ] ] -RRB- cord-329844-w969lczb 122 13 , , , cord-329844-w969lczb 122 14 is be VBZ cord-329844-w969lczb 122 15 not not RB cord-329844-w969lczb 122 16 essential essential JJ cord-329844-w969lczb 122 17 for for IN cord-329844-w969lczb 122 18 reproducing reproduce VBG cord-329844-w969lczb 122 19 the the DT cord-329844-w969lczb 122 20 present present JJ cord-329844-w969lczb 122 21 work work NN cord-329844-w969lczb 122 22 or or CC cord-329844-w969lczb 122 23 for for IN cord-329844-w969lczb 122 24 carrying carry VBG cord-329844-w969lczb 122 25 out out RP cord-329844-w969lczb 122 26 comparable comparable JJ cord-329844-w969lczb 122 27 studies study NNS cord-329844-w969lczb 122 28 , , , cord-329844-w969lczb 122 29 but but CC cord-329844-w969lczb 122 30 it -PRON- PRP cord-329844-w969lczb 122 31 does do VBZ cord-329844-w969lczb 122 32 greatly greatly RB cord-329844-w969lczb 122 33 accelerate accelerate VB cord-329844-w969lczb 122 34 research research NN cord-329844-w969lczb 122 35 and and CC cord-329844-w969lczb 122 36 preparation preparation NN cord-329844-w969lczb 122 37 of of IN cord-329844-w969lczb 122 38 the the DT cord-329844-w969lczb 122 39 scientific scientific JJ cord-329844-w969lczb 122 40 paper paper NN cord-329844-w969lczb 122 41 , , , cord-329844-w969lczb 122 42 allowing allow VBG cord-329844-w969lczb 122 43 fast fast JJ cord-329844-w969lczb 122 44 responses response NNS cord-329844-w969lczb 122 45 to to IN cord-329844-w969lczb 122 46 a a DT cord-329844-w969lczb 122 47 new new JJ cord-329844-w969lczb 122 48 epidemic epidemic NN cord-329844-w969lczb 122 49 [ [ -LRB- cord-329844-w969lczb 122 50 3 3 CD cord-329844-w969lczb 122 51 ] ] -RRB- cord-329844-w969lczb 122 52 [ [ -LRB- cord-329844-w969lczb 122 53 4 4 CD cord-329844-w969lczb 122 54 ] ] -RRB- cord-329844-w969lczb 122 55 [ [ -LRB- cord-329844-w969lczb 122 56 5 5 CD cord-329844-w969lczb 122 57 ] ] -RRB- cord-329844-w969lczb 122 58 . . . cord-329844-w969lczb 123 1 ii ii NNP cord-329844-w969lczb 123 2 . . . cord-329844-w969lczb 124 1 Attempted attempt VBN cord-329844-w969lczb 124 2 discovery discovery NN cord-329844-w969lczb 124 3 of of IN cord-329844-w969lczb 124 4 continuous continuous JJ cord-329844-w969lczb 124 5 short short JJ cord-329844-w969lczb 124 6 sequences sequence NNS cord-329844-w969lczb 124 7 of of IN cord-329844-w969lczb 124 8 amino amino NN cord-329844-w969lczb 124 9 acid acid NN cord-329844-w969lczb 124 10 residues residue NNS cord-329844-w969lczb 124 11 ( ( -LRB- cord-329844-w969lczb 124 12 potential potential JJ cord-329844-w969lczb 124 13 " " `` cord-329844-w969lczb 124 14 sequence sequence NN cord-329844-w969lczb 124 15 motifs motif NNS cord-329844-w969lczb 124 16 " " '' cord-329844-w969lczb 124 17 ) ) -RRB- cord-329844-w969lczb 124 18 with with IN cord-329844-w969lczb 124 19 patterns pattern NNS cord-329844-w969lczb 124 20 and and CC cord-329844-w969lczb 124 21 amino amino NN cord-329844-w969lczb 124 22 acid acid NN cord-329844-w969lczb 124 23 content content NN cord-329844-w969lczb 124 24 common common JJ cord-329844-w969lczb 124 25 to to IN cord-329844-w969lczb 124 26 SARS SARS NNP cord-329844-w969lczb 124 27 - - HYPH cord-329844-w969lczb 124 28 CoV-2 CoV-2 NNP cord-329844-w969lczb 124 29 spike spike NN cord-329844-w969lczb 124 30 protein protein NN cord-329844-w969lczb 124 31 amino amino NN cord-329844-w969lczb 124 32 acid acid NN cord-329844-w969lczb 124 33 sequences sequence NNS cord-329844-w969lczb 124 34 and and CC cord-329844-w969lczb 124 35 hemagglutinins hemagglutinin NNS cord-329844-w969lczb 124 36 and and CC cord-329844-w969lczb 124 37 neuraminidases neuraminidase NNS cord-329844-w969lczb 124 38 , , , cord-329844-w969lczb 124 39 particularly particularly RB cord-329844-w969lczb 124 40 those those DT cord-329844-w969lczb 124 41 of of IN cord-329844-w969lczb 124 42 influenza influenza NN cord-329844-w969lczb 124 43 viruses virus NNS cord-329844-w969lczb 124 44 . . . cord-329844-w969lczb 125 1 Also also RB cord-329844-w969lczb 125 2 , , , cord-329844-w969lczb 125 3 more more RBR cord-329844-w969lczb 125 4 generally generally RB cord-329844-w969lczb 125 5 , , , cord-329844-w969lczb 125 6 in in IN cord-329844-w969lczb 125 7 preparative preparative JJ cord-329844-w969lczb 125 8 work work NN cord-329844-w969lczb 125 9 , , , cord-329844-w969lczb 125 10 comparison comparison NN cord-329844-w969lczb 125 11 of of IN cord-329844-w969lczb 125 12 the the DT cord-329844-w969lczb 125 13 spike spike NN cord-329844-w969lczb 125 14 protein protein NN cord-329844-w969lczb 125 15 sequence sequence NN cord-329844-w969lczb 125 16 of of IN cord-329844-w969lczb 125 17 the the DT cord-329844-w969lczb 125 18 spike spike NN cord-329844-w969lczb 125 19 protein protein NN cord-329844-w969lczb 125 20 with with IN cord-329844-w969lczb 125 21 sialic sialic JJ cord-329844-w969lczb 125 22 acid acid NN cord-329844-w969lczb 125 23 glycan glycan NN cord-329844-w969lczb 125 24 binding bind VBG cord-329844-w969lczb 125 25 proteins protein NNS cord-329844-w969lczb 125 26 and and CC cord-329844-w969lczb 125 27 other other JJ cord-329844-w969lczb 125 28 sugar sugar NN cord-329844-w969lczb 125 29 binding bind VBG cord-329844-w969lczb 125 30 proteins protein NNS cord-329844-w969lczb 125 31 , , , cord-329844-w969lczb 125 32 or or CC cord-329844-w969lczb 125 33 domains domain NNS cord-329844-w969lczb 125 34 of of IN cord-329844-w969lczb 125 35 them -PRON- PRP cord-329844-w969lczb 125 36 . . . cord-329844-w969lczb 126 1 Protein protein NN cord-329844-w969lczb 126 2 sequences sequence NNS cord-329844-w969lczb 126 3 or or CC cord-329844-w969lczb 126 4 parts part NNS cord-329844-w969lczb 126 5 of of IN cord-329844-w969lczb 126 6 them -PRON- PRP cord-329844-w969lczb 126 7 used use VBD cord-329844-w969lczb 126 8 as as IN cord-329844-w969lczb 126 9 input input NN cord-329844-w969lczb 126 10 for for IN cord-329844-w969lczb 126 11 any any DT cord-329844-w969lczb 126 12 part part NN cord-329844-w969lczb 126 13 of of IN cord-329844-w969lczb 126 14 the the DT cord-329844-w969lczb 126 15 study study NN cord-329844-w969lczb 126 16 were be VBD cord-329844-w969lczb 126 17 obtained obtain VBN cord-329844-w969lczb 126 18 from from IN cord-329844-w969lczb 126 19 GenBank GenBank NNP cord-329844-w969lczb 126 20 https://www.ncbi.nlm.nih.gov/genbank/. https://www.ncbi.nlm.nih.gov/genbank/. CD cord-329844-w969lczb 127 1 The the DT cord-329844-w969lczb 127 2 standard standard JJ cord-329844-w969lczb 127 3 method method NN cord-329844-w969lczb 127 4 of of IN cord-329844-w969lczb 127 5 bioinformatics bioinformatic NNS cord-329844-w969lczb 127 6 used use VBN cord-329844-w969lczb 127 7 for for IN cord-329844-w969lczb 127 8 detecting detect VBG cord-329844-w969lczb 127 9 in in IN cord-329844-w969lczb 127 10 large large JJ cord-329844-w969lczb 127 11 protein protein NN cord-329844-w969lczb 127 12 sequence sequence NN cord-329844-w969lczb 127 13 databases database VBZ cord-329844-w969lczb 127 14 any any DT cord-329844-w969lczb 127 15 amino amino NN cord-329844-w969lczb 127 16 acid acid NN cord-329844-w969lczb 127 17 residue residue NN cord-329844-w969lczb 127 18 sequences sequence NNS cord-329844-w969lczb 127 19 similar similar JJ cord-329844-w969lczb 127 20 to to IN cord-329844-w969lczb 127 21 those those DT cord-329844-w969lczb 127 22 of of IN cord-329844-w969lczb 127 23 an an DT cord-329844-w969lczb 127 24 input input NN cord-329844-w969lczb 127 25 sequence sequence NN cord-329844-w969lczb 127 26 was be VBD cord-329844-w969lczb 127 27 primarily primarily RB cord-329844-w969lczb 127 28 BLASTp BLASTp NNS cord-329844-w969lczb 127 29 at at IN cord-329844-w969lczb 127 30 https://blast.ncbi.nlm.nih.gov/ https://blast.ncbi.nlm.nih.gov/ XX cord-329844-w969lczb 127 31 Blast.cgi Blast.cgi NNP cord-329844-w969lczb 127 32 . . . cord-329844-w969lczb 128 1 The the DT cord-329844-w969lczb 128 2 standard standard JJ cord-329844-w969lczb 128 3 tool tool NN cord-329844-w969lczb 128 4 for for IN cord-329844-w969lczb 128 5 a a DT cord-329844-w969lczb 128 6 more more RBR cord-329844-w969lczb 128 7 formal formal JJ cord-329844-w969lczb 128 8 and and CC cord-329844-w969lczb 128 9 typically typically RB cord-329844-w969lczb 128 10 multi multi JJ cord-329844-w969lczb 128 11 - - JJ cord-329844-w969lczb 128 12 sequence sequence JJ cord-329844-w969lczb 128 13 alignment alignment NN cord-329844-w969lczb 128 14 was be VBD cord-329844-w969lczb 128 15 Clustal Clustal NNP cord-329844-w969lczb 128 16 Omega Omega NNP cord-329844-w969lczb 128 17 at at IN cord-329844-w969lczb 128 18 https://www.ebi.ac.uk/ https://www.ebi.ac.uk/ NN cord-329844-w969lczb 129 1 Tools Tools NNPS cord-329844-w969lczb 129 2 / / SYM cord-329844-w969lczb 129 3 msa msa NNP cord-329844-w969lczb 129 4 / / SYM cord-329844-w969lczb 129 5 clustalo/. clustalo/. NNP cord-329844-w969lczb 130 1 These these DT cord-329844-w969lczb 130 2 tools tool NNS cord-329844-w969lczb 130 3 can can MD cord-329844-w969lczb 130 4 be be VB cord-329844-w969lczb 130 5 automatically automatically RB cord-329844-w969lczb 130 6 accessed access VBN cord-329844-w969lczb 130 7 by by IN cord-329844-w969lczb 130 8 the the DT cord-329844-w969lczb 130 9 present present JJ cord-329844-w969lczb 130 10 author author NN cord-329844-w969lczb 130 11 's 's POS cord-329844-w969lczb 130 12 methods method NNS cord-329844-w969lczb 130 13 [ [ -LRB- cord-329844-w969lczb 130 14 4 4 CD cord-329844-w969lczb 130 15 ] ] -RRB- cord-329844-w969lczb 131 1 but but CC cord-329844-w969lczb 131 2 again again RB cord-329844-w969lczb 131 3 that that DT cord-329844-w969lczb 131 4 is be VBZ cord-329844-w969lczb 131 5 not not RB cord-329844-w969lczb 131 6 essential essential JJ cord-329844-w969lczb 131 7 for for IN cord-329844-w969lczb 131 8 reproducibility reproducibility NN cord-329844-w969lczb 131 9 of of IN cord-329844-w969lczb 131 10 the the DT cord-329844-w969lczb 131 11 present present JJ cord-329844-w969lczb 131 12 work work NN cord-329844-w969lczb 131 13 . . . cord-329844-w969lczb 132 1 iii iii NNP cord-329844-w969lczb 132 2 . . . cord-329844-w969lczb 133 1 Examination examination NN cord-329844-w969lczb 133 2 of of IN cord-329844-w969lczb 133 3 patterns pattern NNS cord-329844-w969lczb 133 4 in in IN cord-329844-w969lczb 133 5 potential potential NN cord-329844-w969lczb 133 6 or or CC cord-329844-w969lczb 133 7 known know VBN cord-329844-w969lczb 133 8 short short JJ cord-329844-w969lczb 133 9 subsequences subsequence NNS cord-329844-w969lczb 133 10 in in IN cord-329844-w969lczb 133 11 small small JJ cord-329844-w969lczb 133 12 proteins protein NNS cord-329844-w969lczb 133 13 or or CC cord-329844-w969lczb 133 14 domains domain NNS cord-329844-w969lczb 133 15 known know VBN cord-329844-w969lczb 133 16 to to TO cord-329844-w969lczb 133 17 have have VB cord-329844-w969lczb 133 18 a a DT cord-329844-w969lczb 133 19 function function NN cord-329844-w969lczb 133 20 involving involve VBG cord-329844-w969lczb 133 21 non non JJ cord-329844-w969lczb 133 22 - - JJ cord-329844-w969lczb 133 23 covalent covalent JJ cord-329844-w969lczb 133 24 sialic sialic NN cord-329844-w969lczb 133 25 acid acid NN cord-329844-w969lczb 133 26 binding binding NN cord-329844-w969lczb 133 27 and and CC cord-329844-w969lczb 133 28 , , , cord-329844-w969lczb 133 29 in in IN cord-329844-w969lczb 133 30 absence absence NN cord-329844-w969lczb 133 31 of of IN cord-329844-w969lczb 133 32 any any DT cord-329844-w969lczb 133 33 clear clear JJ cord-329844-w969lczb 133 34 patterns pattern NNS cord-329844-w969lczb 133 35 , , , cord-329844-w969lczb 133 36 study study NN cord-329844-w969lczb 133 37 of of IN cord-329844-w969lczb 133 38 the the DT cord-329844-w969lczb 133 39 amino amino NN cord-329844-w969lczb 133 40 acid acid NN cord-329844-w969lczb 133 41 content content NN cord-329844-w969lczb 133 42 of of IN cord-329844-w969lczb 133 43 the the DT cord-329844-w969lczb 133 44 subsequences subsequence NNS cord-329844-w969lczb 133 45 . . . cord-329844-w969lczb 134 1 This this DT cord-329844-w969lczb 134 2 established establish VBD cord-329844-w969lczb 134 3 a a DT cord-329844-w969lczb 134 4 preliminary preliminary JJ cord-329844-w969lczb 134 5 sialic sialic NN cord-329844-w969lczb 134 6 acid acid NN cord-329844-w969lczb 134 7 glycan glycan NN cord-329844-w969lczb 134 8 binding binding NN cord-329844-w969lczb 134 9 score score NN cord-329844-w969lczb 134 10 ( ( -LRB- cord-329844-w969lczb 134 11 SABS SABS NNP cord-329844-w969lczb 134 12 ) ) -RRB- cord-329844-w969lczb 134 13 for for IN cord-329844-w969lczb 134 14 the the DT cord-329844-w969lczb 134 15 twenty twenty CD cord-329844-w969lczb 134 16 naturally naturally RB cord-329844-w969lczb 134 17 occurring occur VBG cord-329844-w969lczb 134 18 amino amino NN cord-329844-w969lczb 134 19 acid acid NN cord-329844-w969lczb 134 20 residues residue NNS cord-329844-w969lczb 134 21 . . . cord-329844-w969lczb 135 1 However however RB cord-329844-w969lczb 135 2 , , , cord-329844-w969lczb 135 3 the the DT cord-329844-w969lczb 135 4 short short JJ cord-329844-w969lczb 135 5 subsequences subsequence NNS cord-329844-w969lczb 135 6 identified identify VBN cord-329844-w969lczb 135 7 were be VBD cord-329844-w969lczb 135 8 to to TO cord-329844-w969lczb 135 9 be be VB cord-329844-w969lczb 135 10 considered consider VBN cord-329844-w969lczb 135 11 as as IN cord-329844-w969lczb 135 12 " " `` cord-329844-w969lczb 135 13 signals signal NNS cord-329844-w969lczb 135 14 " " '' cord-329844-w969lczb 135 15 or or CC cord-329844-w969lczb 135 16 " " `` cord-329844-w969lczb 135 17 fingerprints fingerprint NNS cord-329844-w969lczb 135 18 " " '' cord-329844-w969lczb 135 19 for for IN cord-329844-w969lczb 135 20 sialic sialic JJ cord-329844-w969lczb 135 21 acid acid NN cord-329844-w969lczb 135 22 glycan glycan NN cord-329844-w969lczb 135 23 binding bind VBG cord-329844-w969lczb 135 24 domains domain NNS cord-329844-w969lczb 135 25 as as IN cord-329844-w969lczb 135 26 a a DT cord-329844-w969lczb 135 27 whole whole NN cord-329844-w969lczb 135 28 . . . cord-329844-w969lczb 136 1 That that RB cord-329844-w969lczb 136 2 is is RB cord-329844-w969lczb 136 3 , , , cord-329844-w969lczb 136 4 direct direct JJ cord-329844-w969lczb 136 5 contact contact NN cord-329844-w969lczb 136 6 with with IN cord-329844-w969lczb 136 7 sialic sialic JJ cord-329844-w969lczb 136 8 acid acid NN cord-329844-w969lczb 136 9 was be VBD cord-329844-w969lczb 136 10 not not RB cord-329844-w969lczb 136 11 necessarily necessarily RB cord-329844-w969lczb 136 12 at at IN cord-329844-w969lczb 136 13 ( ( -LRB- cord-329844-w969lczb 136 14 or or CC cord-329844-w969lczb 136 15 solely solely RB cord-329844-w969lczb 136 16 at at IN cord-329844-w969lczb 136 17 ) ) -RRB- cord-329844-w969lczb 137 1 the the DT cord-329844-w969lczb 137 2 specific specific JJ cord-329844-w969lczb 137 3 short short JJ cord-329844-w969lczb 137 4 subsequence subsequence NN cord-329844-w969lczb 137 5 , , , cord-329844-w969lczb 137 6 for for IN cord-329844-w969lczb 137 7 reasons reason NNS cord-329844-w969lczb 137 8 discussed discuss VBN cord-329844-w969lczb 137 9 in in IN cord-329844-w969lczb 137 10 Results Results NNP cord-329844-w969lczb 137 11 Section Section NNP cord-329844-w969lczb 137 12 4 4 CD cord-329844-w969lczb 137 13 . . . cord-329844-w969lczb 138 1 This this DT cord-329844-w969lczb 138 2 , , , cord-329844-w969lczb 138 3 plus plus CC cord-329844-w969lczb 138 4 a a DT cord-329844-w969lczb 138 5 sequence sequence NN cord-329844-w969lczb 138 6 rather rather RB cord-329844-w969lczb 138 7 than than IN cord-329844-w969lczb 138 8 three three CD cord-329844-w969lczb 138 9 dimensional dimensional JJ cord-329844-w969lczb 138 10 structure structure NN cord-329844-w969lczb 138 11 perspective perspective NN cord-329844-w969lczb 138 12 , , , cord-329844-w969lczb 138 13 and and CC cord-329844-w969lczb 138 14 a a DT cord-329844-w969lczb 138 15 specific specific JJ cord-329844-w969lczb 138 16 focus focus NN cord-329844-w969lczb 138 17 on on IN cord-329844-w969lczb 138 18 binding bind VBG cord-329844-w969lczb 138 19 sialic sialic JJ cord-329844-w969lczb 138 20 acid acid NN cord-329844-w969lczb 138 21 glycans glycan NNS cord-329844-w969lczb 138 22 rather rather RB cord-329844-w969lczb 138 23 than than IN cord-329844-w969lczb 138 24 sugars sugar NNS cord-329844-w969lczb 138 25 in in IN cord-329844-w969lczb 138 26 general general JJ cord-329844-w969lczb 138 27 , , , cord-329844-w969lczb 138 28 resulted result VBD cord-329844-w969lczb 138 29 in in IN cord-329844-w969lczb 138 30 a a DT cord-329844-w969lczb 138 31 substantial substantial JJ cord-329844-w969lczb 138 32 difference difference NN cord-329844-w969lczb 138 33 in in IN cord-329844-w969lczb 138 34 scores score NNS cord-329844-w969lczb 138 35 from from IN cord-329844-w969lczb 138 36 another another DT cord-329844-w969lczb 138 37 major major JJ cord-329844-w969lczb 138 38 method method NN cord-329844-w969lczb 138 39 of of IN cord-329844-w969lczb 138 40 predicting predict VBG cord-329844-w969lczb 138 41 sugar sugar NN cord-329844-w969lczb 138 42 binding bind VBG cord-329844-w969lczb 138 43 regions region NNS cord-329844-w969lczb 138 44 of of IN cord-329844-w969lczb 138 45 proteins protein NNS cord-329844-w969lczb 138 46 also also RB cord-329844-w969lczb 138 47 discussed discuss VBN cord-329844-w969lczb 138 48 later later RB cord-329844-w969lczb 138 49 below below RB cord-329844-w969lczb 138 50 . . . cord-329844-w969lczb 139 1 iv iv LS cord-329844-w969lczb 139 2 . . . cord-329844-w969lczb 140 1 Development development NN cord-329844-w969lczb 140 2 of of IN cord-329844-w969lczb 140 3 the the DT cord-329844-w969lczb 140 4 above above JJ cord-329844-w969lczb 140 5 as as IN cord-329844-w969lczb 140 6 an an DT cord-329844-w969lczb 140 7 algorithm algorithm NN cord-329844-w969lczb 140 8 SABR sabr NN cord-329844-w969lczb 140 9 - - HYPH cord-329844-w969lczb 140 10 P p NN cord-329844-w969lczb 140 11 for for IN cord-329844-w969lczb 140 12 identifying identify VBG cord-329844-w969lczb 140 13 potential potential JJ cord-329844-w969lczb 140 14 small small JJ cord-329844-w969lczb 140 15 proteins protein NNS cord-329844-w969lczb 140 16 or or CC cord-329844-w969lczb 140 17 domains domain NNS cord-329844-w969lczb 140 18 of of IN cord-329844-w969lczb 140 19 proteins protein NNS cord-329844-w969lczb 140 20 that that IN cord-329844-w969lczb 140 21 non non JJ cord-329844-w969lczb 140 22 - - JJ cord-329844-w969lczb 140 23 covalently covalently RB cord-329844-w969lczb 140 24 bind bind VB cord-329844-w969lczb 140 25 sialic sialic NN cord-329844-w969lczb 140 26 acid acid NN cord-329844-w969lczb 140 27 glycans glycan NNS cord-329844-w969lczb 140 28 , , , cord-329844-w969lczb 140 29 by by IN cord-329844-w969lczb 140 30 predictions prediction NNS cord-329844-w969lczb 140 31 on on IN cord-329844-w969lczb 140 32 a a DT cord-329844-w969lczb 140 33 test test NN cord-329844-w969lczb 140 34 data datum NNS cord-329844-w969lczb 140 35 set set VBN cord-329844-w969lczb 140 36 of of IN cord-329844-w969lczb 140 37 protein protein NN cord-329844-w969lczb 140 38 sequences sequence NNS cord-329844-w969lczb 140 39 . . . cord-329844-w969lczb 141 1 As as IN cord-329844-w969lczb 141 2 noted note VBN cord-329844-w969lczb 141 3 above above IN cord-329844-w969lczb 141 4 the the DT cord-329844-w969lczb 141 5 subsequences subsequence NNS cord-329844-w969lczb 141 6 predicted predict VBN cord-329844-w969lczb 141 7 are be VBP cord-329844-w969lczb 141 8 taken take VBN cord-329844-w969lczb 141 9 to to TO cord-329844-w969lczb 141 10 indicate indicate VB cord-329844-w969lczb 141 11 the the DT cord-329844-w969lczb 141 12 glycan glycan NN cord-329844-w969lczb 141 13 binding bind VBG cord-329844-w969lczb 141 14 domain domain NN cord-329844-w969lczb 141 15 as as IN cord-329844-w969lczb 141 16 a a DT cord-329844-w969lczb 141 17 whole whole NN cord-329844-w969lczb 141 18 , , , cord-329844-w969lczb 141 19 not not RB cord-329844-w969lczb 141 20 necessarily necessarily RB cord-329844-w969lczb 141 21 the the DT cord-329844-w969lczb 141 22 sialic sialic JJ cord-329844-w969lczb 141 23 acid acid NN cord-329844-w969lczb 141 24 sites site NNS cord-329844-w969lczb 141 25 per per FW cord-329844-w969lczb 141 26 se se FW cord-329844-w969lczb 141 27 , , , cord-329844-w969lczb 141 28 but but CC cord-329844-w969lczb 141 29 they -PRON- PRP cord-329844-w969lczb 141 30 may may MD cord-329844-w969lczb 141 31 be be VB cord-329844-w969lczb 141 32 . . . cord-329844-w969lczb 142 1 This this DT cord-329844-w969lczb 142 2 approach approach NN cord-329844-w969lczb 142 3 involved involve VBD cord-329844-w969lczb 142 4 noting note VBG cord-329844-w969lczb 142 5 true true JJ cord-329844-w969lczb 142 6 positive positive JJ cord-329844-w969lczb 142 7 and and CC cord-329844-w969lczb 142 8 negative negative JJ cord-329844-w969lczb 142 9 predictions prediction NNS cord-329844-w969lczb 142 10 and and CC cord-329844-w969lczb 142 11 false false JJ cord-329844-w969lczb 142 12 positives positive NNS cord-329844-w969lczb 142 13 and and CC cord-329844-w969lczb 142 14 negative negative JJ cord-329844-w969lczb 142 15 predictions prediction NNS cord-329844-w969lczb 142 16 so so IN cord-329844-w969lczb 142 17 as as IN cord-329844-w969lczb 142 18 to to TO cord-329844-w969lczb 142 19 optimize optimize VB cord-329844-w969lczb 142 20 sensitivity sensitivity NN cord-329844-w969lczb 142 21 and and CC cord-329844-w969lczb 142 22 specificity specificity NN cord-329844-w969lczb 142 23 . . . cord-329844-w969lczb 143 1 This this DT cord-329844-w969lczb 143 2 was be VBD cord-329844-w969lczb 143 3 done do VBN cord-329844-w969lczb 143 4 specifically specifically RB cord-329844-w969lczb 143 5 in in IN cord-329844-w969lczb 143 6 regard regard NN cord-329844-w969lczb 143 7 to to IN cord-329844-w969lczb 143 8 non non JJ cord-329844-w969lczb 143 9 - - JJ cord-329844-w969lczb 143 10 covalent covalent JJ cord-329844-w969lczb 143 11 binding binding NN cord-329844-w969lczb 143 12 of of IN cord-329844-w969lczb 143 13 sialic sialic JJ cord-329844-w969lczb 143 14 acid acid NN cord-329844-w969lczb 143 15 glycans glycan NNS cord-329844-w969lczb 143 16 . . . cord-329844-w969lczb 144 1 In in IN cord-329844-w969lczb 144 2 other other JJ cord-329844-w969lczb 144 3 words word NNS cord-329844-w969lczb 144 4 , , , cord-329844-w969lczb 144 5 it -PRON- PRP cord-329844-w969lczb 144 6 was be VBD cord-329844-w969lczb 144 7 done do VBN cord-329844-w969lczb 144 8 so so IN cord-329844-w969lczb 144 9 as as IN cord-329844-w969lczb 144 10 to to IN cord-329844-w969lczb 144 11 distinguished distinguished JJ cord-329844-w969lczb 144 12 sialic sialic JJ cord-329844-w969lczb 144 13 acid acid NN cord-329844-w969lczb 144 14 glycan glycan NN cord-329844-w969lczb 144 15 binding bind VBG cord-329844-w969lczb 144 16 domains domain NNS cord-329844-w969lczb 144 17 not not RB cord-329844-w969lczb 144 18 only only RB cord-329844-w969lczb 144 19 from from IN cord-329844-w969lczb 144 20 those those DT cord-329844-w969lczb 144 21 domains domain NNS cord-329844-w969lczb 144 22 known know VBN cord-329844-w969lczb 144 23 not not RB cord-329844-w969lczb 144 24 to to TO cord-329844-w969lczb 144 25 bind bind VB cord-329844-w969lczb 144 26 sugars sugar NNS cord-329844-w969lczb 144 27 but but CC cord-329844-w969lczb 144 28 also also RB cord-329844-w969lczb 144 29 from from IN cord-329844-w969lczb 144 30 those those DT cord-329844-w969lczb 144 31 that that WDT cord-329844-w969lczb 144 32 bind bind VBP cord-329844-w969lczb 144 33 sugars sugar NNS cord-329844-w969lczb 144 34 and and CC cord-329844-w969lczb 144 35 glycans glycan NNS cord-329844-w969lczb 144 36 that that WDT cord-329844-w969lczb 144 37 do do VBP cord-329844-w969lczb 144 38 not not RB cord-329844-w969lczb 144 39 contain contain VB cord-329844-w969lczb 144 40 sialic sialic JJ cord-329844-w969lczb 144 41 acid acid NN cord-329844-w969lczb 144 42 . . . cord-329844-w969lczb 145 1 v. v. CC cord-329844-w969lczb 145 2 Examination Examination NNP cord-329844-w969lczb 145 3 of of IN cord-329844-w969lczb 145 4 the the DT cord-329844-w969lczb 145 5 three three CD cord-329844-w969lczb 145 6 dimensional dimensional JJ cord-329844-w969lczb 145 7 structures structure NNS cord-329844-w969lczb 145 8 of of IN cord-329844-w969lczb 145 9 regions region NNS cord-329844-w969lczb 145 10 of of IN cord-329844-w969lczb 145 11 the the DT cord-329844-w969lczb 145 12 regions region NNS cord-329844-w969lczb 145 13 of of IN cord-329844-w969lczb 145 14 the the DT cord-329844-w969lczb 145 15 SARS SARS NNP cord-329844-w969lczb 145 16 - - HYPH cord-329844-w969lczb 145 17 CoV-2 CoV-2 NNP cord-329844-w969lczb 145 18 spike spike NN cord-329844-w969lczb 145 19 protein protein NN cord-329844-w969lczb 145 20 predicted predict VBD cord-329844-w969lczb 145 21 as as IN cord-329844-w969lczb 145 22 binding bind VBG cord-329844-w969lczb 145 23 sialic sialic JJ cord-329844-w969lczb 145 24 acid acid NN cord-329844-w969lczb 145 25 glycans glycan NNS cord-329844-w969lczb 145 26 to to TO cord-329844-w969lczb 145 27 propose propose VB cord-329844-w969lczb 145 28 and and CC cord-329844-w969lczb 145 29 locate locate VB cord-329844-w969lczb 145 30 a a DT cord-329844-w969lczb 145 31 sialic sialic JJ cord-329844-w969lczb 145 32 acid acid NN cord-329844-w969lczb 145 33 binding bind VBG cord-329844-w969lczb 145 34 function function NN cord-329844-w969lczb 145 35 of of IN cord-329844-w969lczb 145 36 SARS SARS NNP cord-329844-w969lczb 145 37 - - HYPH cord-329844-w969lczb 145 38 CoV-2 CoV-2 NNP cord-329844-w969lczb 146 1 ( ( -LRB- cord-329844-w969lczb 146 2 possibly possibly RB cord-329844-w969lczb 146 3 but but CC cord-329844-w969lczb 146 4 not not RB cord-329844-w969lczb 146 5 necessarily necessarily RB cord-329844-w969lczb 146 6 associated associate VBN cord-329844-w969lczb 146 7 with with IN cord-329844-w969lczb 146 8 some some DT cord-329844-w969lczb 146 9 kind kind NN cord-329844-w969lczb 146 10 of of IN cord-329844-w969lczb 146 11 enzymic enzymic NN cord-329844-w969lczb 146 12 activity activity NN cord-329844-w969lczb 146 13 ) ) -RRB- cord-329844-w969lczb 146 14 . . . cord-329844-w969lczb 147 1 Results result NNS cord-329844-w969lczb 147 2 and and CC cord-329844-w969lczb 147 3 discussion discussion NN cord-329844-w969lczb 147 4 in in IN cord-329844-w969lczb 147 5 the the DT cord-329844-w969lczb 147 6 present present JJ cord-329844-w969lczb 147 7 paper paper NN cord-329844-w969lczb 147 8 used use VBD cord-329844-w969lczb 147 9 the the DT cord-329844-w969lczb 147 10 same same JJ cord-329844-w969lczb 147 11 amino amino NN cord-329844-w969lczb 147 12 acid acid NN cord-329844-w969lczb 147 13 codes code NNS cord-329844-w969lczb 147 14 as as IN cord-329844-w969lczb 147 15 the the DT cord-329844-w969lczb 147 16 above above JJ cord-329844-w969lczb 147 17 tools tool NNS cord-329844-w969lczb 147 18 and and CC cord-329844-w969lczb 147 19 data datum NNS cord-329844-w969lczb 147 20 bank bank NN cord-329844-w969lczb 147 21 use use NN cord-329844-w969lczb 147 22 , , , cord-329844-w969lczb 147 23 i.e. i.e. FW cord-329844-w969lczb 147 24 the the DT cord-329844-w969lczb 147 25 IUPAC IUPAC NNP cord-329844-w969lczb 147 26 ( ( -LRB- cord-329844-w969lczb 147 27 International International NNP cord-329844-w969lczb 147 28 Union Union NNP cord-329844-w969lczb 147 29 of of IN cord-329844-w969lczb 147 30 Pure Pure NNP cord-329844-w969lczb 147 31 and and CC cord-329844-w969lczb 147 32 Applied Applied NNP cord-329844-w969lczb 147 33 Chemistry Chemistry NNP cord-329844-w969lczb 147 34 ) ) -RRB- cord-329844-w969lczb 148 1 one one CD cord-329844-w969lczb 148 2 letter letter NN cord-329844-w969lczb 148 3 amino amino NN cord-329844-w969lczb 148 4 acid acid NN cord-329844-w969lczb 148 5 codes code NNS cord-329844-w969lczb 148 6 , , , cord-329844-w969lczb 148 7 given give VBN cord-329844-w969lczb 148 8 in in IN cord-329844-w969lczb 148 9 Table Table NNP cord-329844-w969lczb 148 10 1 1 CD cord-329844-w969lczb 148 11 below below RB cord-329844-w969lczb 148 12 . . . cord-329844-w969lczb 149 1 For for IN cord-329844-w969lczb 149 2 completeness completeness NN cord-329844-w969lczb 149 3 , , , cord-329844-w969lczb 149 4 conservative conservative JJ cord-329844-w969lczb 149 5 replacements replacement NNS cord-329844-w969lczb 149 6 in in IN cord-329844-w969lczb 149 7 column column NN cord-329844-w969lczb 149 8 3 3 CD cord-329844-w969lczb 149 9 of of IN cord-329844-w969lczb 149 10 Table Table NNP cord-329844-w969lczb 149 11 1 1 CD cord-329844-w969lczb 149 12 are be VBP cord-329844-w969lczb 149 13 given give VBN cord-329844-w969lczb 149 14 . . . cord-329844-w969lczb 150 1 They -PRON- PRP cord-329844-w969lczb 150 2 relate relate VBP cord-329844-w969lczb 150 3 largely largely RB cord-329844-w969lczb 150 4 to to IN cord-329844-w969lczb 150 5 substitutions substitution NNS cord-329844-w969lczb 150 6 that that WDT cord-329844-w969lczb 150 7 can can MD cord-329844-w969lczb 150 8 usefully usefully RB cord-329844-w969lczb 150 9 be be VB cord-329844-w969lczb 150 10 made make VBN cord-329844-w969lczb 150 11 in in IN cord-329844-w969lczb 150 12 the the DT cord-329844-w969lczb 150 13 design design NN cord-329844-w969lczb 150 14 of of IN cord-329844-w969lczb 150 15 synthetic synthetic JJ cord-329844-w969lczb 150 16 peptides peptide NNS cord-329844-w969lczb 150 17 [ [ -LRB- cord-329844-w969lczb 150 18 4 4 CD cord-329844-w969lczb 150 19 , , , cord-329844-w969lczb 150 20 5 5 CD cord-329844-w969lczb 150 21 ] ] -RRB- cord-329844-w969lczb 150 22 . . . cord-329844-w969lczb 151 1 This this DT cord-329844-w969lczb 151 2 is be VBZ cord-329844-w969lczb 151 3 an an DT cord-329844-w969lczb 151 4 application application NN cord-329844-w969lczb 151 5 which which WDT cord-329844-w969lczb 151 6 is be VBZ cord-329844-w969lczb 151 7 not not RB cord-329844-w969lczb 151 8 specifically specifically RB cord-329844-w969lczb 151 9 discussed discuss VBN cord-329844-w969lczb 151 10 in in IN cord-329844-w969lczb 151 11 the the DT cord-329844-w969lczb 151 12 present present JJ cord-329844-w969lczb 151 13 paper paper NN cord-329844-w969lczb 151 14 but but CC cord-329844-w969lczb 151 15 which which WDT cord-329844-w969lczb 151 16 could could MD cord-329844-w969lczb 151 17 be be VB cord-329844-w969lczb 151 18 a a DT cord-329844-w969lczb 151 19 basis basis NN cord-329844-w969lczb 151 20 for for IN cord-329844-w969lczb 151 21 design design NN cord-329844-w969lczb 151 22 of of IN cord-329844-w969lczb 151 23 synthetic synthetic JJ cord-329844-w969lczb 151 24 vaccines vaccine NNS cord-329844-w969lczb 151 25 and and CC cord-329844-w969lczb 151 26 preventative preventative JJ cord-329844-w969lczb 151 27 or or CC cord-329844-w969lczb 151 28 therapeutic therapeutic JJ cord-329844-w969lczb 151 29 agents agent NNS cord-329844-w969lczb 151 30 [ [ -LRB- cord-329844-w969lczb 151 31 4 4 CD cord-329844-w969lczb 151 32 , , , cord-329844-w969lczb 151 33 5 5 CD cord-329844-w969lczb 151 34 ] ] -RRB- cord-329844-w969lczb 151 35 , , , cord-329844-w969lczb 151 36 in in IN cord-329844-w969lczb 151 37 this this DT cord-329844-w969lczb 151 38 case case NN cord-329844-w969lczb 151 39 targeted target VBN cord-329844-w969lczb 151 40 at at IN cord-329844-w969lczb 151 41 sialic sialic JJ cord-329844-w969lczb 151 42 acid acid NN cord-329844-w969lczb 151 43 glycan glycan NN cord-329844-w969lczb 151 44 binding bind VBG cord-329844-w969lczb 151 45 site site NN cord-329844-w969lczb 151 46 of of IN cord-329844-w969lczb 151 47 a a DT cord-329844-w969lczb 151 48 virus virus NN cord-329844-w969lczb 151 49 . . . cord-329844-w969lczb 152 1 As as IN cord-329844-w969lczb 152 2 discussed discuss VBN cord-329844-w969lczb 152 3 in in IN cord-329844-w969lczb 152 4 the the DT cord-329844-w969lczb 152 5 sequence sequence NN cord-329844-w969lczb 152 6 of of IN cord-329844-w969lczb 152 7 steps step NNS cord-329844-w969lczb 152 8 for for IN cord-329844-w969lczb 152 9 the the DT cord-329844-w969lczb 152 10 methodology methodology NN cord-329844-w969lczb 152 11 above above RB cord-329844-w969lczb 152 12 , , , cord-329844-w969lczb 152 13 the the DT cord-329844-w969lczb 152 14 sialic sialic JJ cord-329844-w969lczb 152 15 acid acid NN cord-329844-w969lczb 152 16 glycan glycan NN cord-329844-w969lczb 152 17 binding binding NN cord-329844-w969lczb 152 18 motifs motif NNS cord-329844-w969lczb 152 19 are be VBP cord-329844-w969lczb 152 20 taken take VBN cord-329844-w969lczb 152 21 to to TO cord-329844-w969lczb 152 22 be be VB cord-329844-w969lczb 152 23 indicators indicator NNS cord-329844-w969lczb 152 24 of of IN cord-329844-w969lczb 152 25 the the DT cord-329844-w969lczb 152 26 sialic sialic JJ cord-329844-w969lczb 152 27 acid acid NN cord-329844-w969lczb 152 28 binding bind VBG cord-329844-w969lczb 152 29 domain domain NN cord-329844-w969lczb 152 30 and and CC cord-329844-w969lczb 152 31 not not RB cord-329844-w969lczb 152 32 necessarily necessarily RB cord-329844-w969lczb 152 33 of of IN cord-329844-w969lczb 152 34 the the DT cord-329844-w969lczb 152 35 target target NN cord-329844-w969lczb 152 36 sites site NNS cord-329844-w969lczb 152 37 per per FW cord-329844-w969lczb 152 38 se se FW cord-329844-w969lczb 152 39 , , , cord-329844-w969lczb 152 40 but but CC cord-329844-w969lczb 152 41 they -PRON- PRP cord-329844-w969lczb 152 42 may may MD cord-329844-w969lczb 152 43 be be VB cord-329844-w969lczb 152 44 , , , cord-329844-w969lczb 152 45 and and CC cord-329844-w969lczb 152 46 often often RB cord-329844-w969lczb 152 47 are be VBP cord-329844-w969lczb 152 48 , , , cord-329844-w969lczb 152 49 potential potential JJ cord-329844-w969lczb 152 50 target target NN cord-329844-w969lczb 152 51 sites site NNS cord-329844-w969lczb 152 52 . . . cord-329844-w969lczb 153 1 The the DT cord-329844-w969lczb 153 2 list list NN cord-329844-w969lczb 153 3 of of IN cord-329844-w969lczb 153 4 conservative conservative JJ cord-329844-w969lczb 153 5 replacements replacement NNS cord-329844-w969lczb 153 6 also also RB cord-329844-w969lczb 153 7 remains remain VBZ cord-329844-w969lczb 153 8 useful useful JJ cord-329844-w969lczb 153 9 for for IN cord-329844-w969lczb 153 10 considering consider VBG cord-329844-w969lczb 153 11 substitutions substitution NNS cord-329844-w969lczb 153 12 that that WDT cord-329844-w969lczb 153 13 are be VBP cord-329844-w969lczb 153 14 conservative conservative JJ cord-329844-w969lczb 153 15 in in IN cord-329844-w969lczb 153 16 maintaining maintain VBG cord-329844-w969lczb 153 17 similar similar JJ cord-329844-w969lczb 153 18 amino amino NN cord-329844-w969lczb 153 19 acid acid NN cord-329844-w969lczb 153 20 properties property NNS cord-329844-w969lczb 153 21 when when WRB cord-329844-w969lczb 153 22 detecting detect VBG cord-329844-w969lczb 153 23 and and CC cord-329844-w969lczb 153 24 comparing compare VBG cord-329844-w969lczb 153 25 related related JJ cord-329844-w969lczb 153 26 sequences sequence NNS cord-329844-w969lczb 153 27 . . . cord-329844-w969lczb 154 1 Since since IN cord-329844-w969lczb 154 2 for for IN cord-329844-w969lczb 154 3 both both DT cord-329844-w969lczb 154 4 reasons reason NNS cord-329844-w969lczb 154 5 they -PRON- PRP cord-329844-w969lczb 154 6 be be VBP cord-329844-w969lczb 154 7 useful useful JJ cord-329844-w969lczb 154 8 in in IN cord-329844-w969lczb 154 9 deeper deep JJR cord-329844-w969lczb 154 10 consideration consideration NN cord-329844-w969lczb 154 11 of of IN cord-329844-w969lczb 154 12 many many JJ cord-329844-w969lczb 154 13 results result NNS cord-329844-w969lczb 154 14 in in IN cord-329844-w969lczb 154 15 the the DT cord-329844-w969lczb 154 16 present present JJ cord-329844-w969lczb 154 17 paper paper NN cord-329844-w969lczb 154 18 , , , cord-329844-w969lczb 154 19 some some DT cord-329844-w969lczb 154 20 comment comment NN cord-329844-w969lczb 154 21 may may MD cord-329844-w969lczb 154 22 be be VB cord-329844-w969lczb 154 23 useful useful JJ cord-329844-w969lczb 154 24 to to IN cord-329844-w969lczb 154 25 researchers researcher NNS cord-329844-w969lczb 154 26 less less RBR cord-329844-w969lczb 154 27 familiar familiar JJ cord-329844-w969lczb 154 28 with with IN cord-329844-w969lczb 154 29 bioinformatics bioinformatic NNS cord-329844-w969lczb 154 30 . . . cord-329844-w969lczb 155 1 See see VB cord-329844-w969lczb 155 2 ref ref NN cord-329844-w969lczb 155 3 [ [ -LRB- cord-329844-w969lczb 155 4 4 4 CD cord-329844-w969lczb 155 5 ] ] -RRB- cord-329844-w969lczb 155 6 for for IN cord-329844-w969lczb 155 7 a a DT cord-329844-w969lczb 155 8 further further JJ cord-329844-w969lczb 155 9 account account NN cord-329844-w969lczb 155 10 . . . cord-329844-w969lczb 156 1 Note note VB cord-329844-w969lczb 156 2 that that IN cord-329844-w969lczb 156 3 the the DT cord-329844-w969lczb 156 4 work work NN cord-329844-w969lczb 156 5 of of IN cord-329844-w969lczb 156 6 considering consider VBG cord-329844-w969lczb 156 7 what what WP cord-329844-w969lczb 156 8 is be VBZ cord-329844-w969lczb 156 9 a a DT cord-329844-w969lczb 156 10 conservative conservative JJ cord-329844-w969lczb 156 11 replacement replacement NN cord-329844-w969lczb 156 12 is be VBZ cord-329844-w969lczb 156 13 done do VBN cord-329844-w969lczb 156 14 automatically automatically RB cord-329844-w969lczb 156 15 by by IN cord-329844-w969lczb 156 16 the the DT cord-329844-w969lczb 156 17 standard standard JJ cord-329844-w969lczb 156 18 bioinformatics bioinformatic NNS cord-329844-w969lczb 156 19 tools tool NNS cord-329844-w969lczb 156 20 used use VBN cord-329844-w969lczb 156 21 . . . cord-329844-w969lczb 157 1 The the DT cord-329844-w969lczb 157 2 replacements replacement NNS cord-329844-w969lczb 157 3 in in IN cord-329844-w969lczb 157 4 Table table NN cord-329844-w969lczb 157 5 1 1 CD cord-329844-w969lczb 157 6 are be VBP cord-329844-w969lczb 157 7 consistent consistent JJ cord-329844-w969lczb 157 8 with with IN cord-329844-w969lczb 157 9 the the DT cord-329844-w969lczb 157 10 conservative conservative JJ cord-329844-w969lczb 157 11 replacement replacement NN cord-329844-w969lczb 157 12 rules rule NNS cord-329844-w969lczb 157 13 implied imply VBN cord-329844-w969lczb 157 14 by by IN cord-329844-w969lczb 157 15 the the DT cord-329844-w969lczb 157 16 tables table NNS cord-329844-w969lczb 157 17 of of IN cord-329844-w969lczb 157 18 weights weight NNS cord-329844-w969lczb 157 19 implemented implement VBN cord-329844-w969lczb 157 20 automatically automatically RB cord-329844-w969lczb 157 21 in in IN cord-329844-w969lczb 157 22 BLASTp BLASTp NNS cord-329844-w969lczb 157 23 and and CC cord-329844-w969lczb 157 24 Clustal Clustal NNP cord-329844-w969lczb 157 25 Omega Omega NNP cord-329844-w969lczb 157 26 mentioned mention VBD cord-329844-w969lczb 157 27 above above RB cord-329844-w969lczb 157 28 , , , cord-329844-w969lczb 157 29 which which WDT cord-329844-w969lczb 157 30 are be VBP cord-329844-w969lczb 157 31 discussed discuss VBN cord-329844-w969lczb 157 32 at at IN cord-329844-w969lczb 157 33 those those DT cord-329844-w969lczb 157 34 sites site NNS cord-329844-w969lczb 157 35 . . . cord-329844-w969lczb 158 1 However however RB cord-329844-w969lczb 158 2 , , , cord-329844-w969lczb 158 3 the the DT cord-329844-w969lczb 158 4 original original JJ cord-329844-w969lczb 158 5 intent intent NN cord-329844-w969lczb 158 6 as as IN cord-329844-w969lczb 158 7 an an DT cord-329844-w969lczb 158 8 application application NN cord-329844-w969lczb 158 9 to to IN cord-329844-w969lczb 158 10 peptide peptide NN cord-329844-w969lczb 158 11 design design NN cord-329844-w969lczb 158 12 means mean VBZ cord-329844-w969lczb 158 13 that that IN cord-329844-w969lczb 158 14 in in IN cord-329844-w969lczb 158 15 Table Table NNP cord-329844-w969lczb 158 16 1 1 CD cord-329844-w969lczb 158 17 there there EX cord-329844-w969lczb 158 18 is be VBZ cord-329844-w969lczb 158 19 a a DT cord-329844-w969lczb 158 20 degree degree NN cord-329844-w969lczb 158 21 of of IN cord-329844-w969lczb 158 22 asymmetry asymmetry NN cord-329844-w969lczb 158 23 based base VBN cord-329844-w969lczb 158 24 on on IN cord-329844-w969lczb 158 25 the the DT cord-329844-w969lczb 158 26 author author NN cord-329844-w969lczb 158 27 's 's POS cord-329844-w969lczb 158 28 experience experience NN cord-329844-w969lczb 158 29 in in IN cord-329844-w969lczb 158 30 peptide peptide NN cord-329844-w969lczb 158 31 design design NN cord-329844-w969lczb 158 32 [ [ -LRB- cord-329844-w969lczb 158 33 4 4 CD cord-329844-w969lczb 158 34 ] ] -RRB- cord-329844-w969lczb 158 35 because because IN cord-329844-w969lczb 158 36 one one CD cord-329844-w969lczb 158 37 is be VBZ cord-329844-w969lczb 158 38 going go VBG cord-329844-w969lczb 158 39 from from IN cord-329844-w969lczb 158 40 a a DT cord-329844-w969lczb 158 41 natural natural JJ cord-329844-w969lczb 158 42 protein protein NN cord-329844-w969lczb 158 43 state state NN cord-329844-w969lczb 158 44 to to IN cord-329844-w969lczb 158 45 less less RBR cord-329844-w969lczb 158 46 natural natural JJ cord-329844-w969lczb 158 47 one one NN cord-329844-w969lczb 158 48 without without IN cord-329844-w969lczb 158 49 evolution evolution NN cord-329844-w969lczb 158 50 making make VBG cord-329844-w969lczb 158 51 compensatory compensatory JJ cord-329844-w969lczb 158 52 changes change NNS cord-329844-w969lczb 158 53 in in IN cord-329844-w969lczb 158 54 the the DT cord-329844-w969lczb 158 55 rest rest NN cord-329844-w969lczb 158 56 of of IN cord-329844-w969lczb 158 57 the the DT cord-329844-w969lczb 158 58 protein protein NN cord-329844-w969lczb 158 59 or or CC cord-329844-w969lczb 158 60 system system NN cord-329844-w969lczb 158 61 . . . cord-329844-w969lczb 159 1 For for IN cord-329844-w969lczb 159 2 example example NN cord-329844-w969lczb 159 3 , , , cord-329844-w969lczb 159 4 empirical empirical JJ cord-329844-w969lczb 159 5 studies study NNS cord-329844-w969lczb 159 6 show show VBP cord-329844-w969lczb 159 7 that that IN cord-329844-w969lczb 159 8 serine serine NN cord-329844-w969lczb 159 9 ( ( -LRB- cord-329844-w969lczb 159 10 S s NN cord-329844-w969lczb 159 11 ) ) -RRB- cord-329844-w969lczb 159 12 can can MD cord-329844-w969lczb 159 13 be be VB cord-329844-w969lczb 159 14 replaced replace VBN cord-329844-w969lczb 159 15 by by IN cord-329844-w969lczb 159 16 alanine alanine NN cord-329844-w969lczb 159 17 ( ( -LRB- cord-329844-w969lczb 159 18 A a NN cord-329844-w969lczb 159 19 ) ) -RRB- cord-329844-w969lczb 159 20 or or CC cord-329844-w969lczb 159 21 threonine threonine NN cord-329844-w969lczb 159 22 ( ( -LRB- cord-329844-w969lczb 159 23 T T NNP cord-329844-w969lczb 159 24 ) ) -RRB- cord-329844-w969lczb 159 25 but but CC cord-329844-w969lczb 159 26 it -PRON- PRP cord-329844-w969lczb 159 27 is be VBZ cord-329844-w969lczb 159 28 frequently frequently RB cord-329844-w969lczb 159 29 important important JJ cord-329844-w969lczb 159 30 that that IN cord-329844-w969lczb 159 31 a a DT cord-329844-w969lczb 159 32 replacement replacement NN cord-329844-w969lczb 159 33 to to IN cord-329844-w969lczb 159 34 threonine threonine NN cord-329844-w969lczb 159 35 should should MD cord-329844-w969lczb 159 36 be be VB cord-329844-w969lczb 159 37 isoleucine isoleucine JJ cord-329844-w969lczb 159 38 ( ( -LRB- cord-329844-w969lczb 159 39 I i NN cord-329844-w969lczb 159 40 ) ) -RRB- cord-329844-w969lczb 159 41 in in IN cord-329844-w969lczb 159 42 order order NN cord-329844-w969lczb 159 43 to to TO cord-329844-w969lczb 159 44 retain retain VB cord-329844-w969lczb 159 45 stability stability NN cord-329844-w969lczb 159 46 of of IN cord-329844-w969lczb 159 47 a a DT cord-329844-w969lczb 159 48 βpleated βpleated JJ cord-329844-w969lczb 159 49 sheet sheet NN cord-329844-w969lczb 159 50 in in IN cord-329844-w969lczb 159 51 which which WDT cord-329844-w969lczb 159 52 they -PRON- PRP cord-329844-w969lczb 159 53 occur occur VBP cord-329844-w969lczb 159 54 . . . cord-329844-w969lczb 160 1 Strictly strictly RB cord-329844-w969lczb 160 2 speaking speak VBG cord-329844-w969lczb 160 3 , , , cord-329844-w969lczb 160 4 these these DT cord-329844-w969lczb 160 5 are be VBP cord-329844-w969lczb 160 6 just just RB cord-329844-w969lczb 160 7 fairly fairly RB cord-329844-w969lczb 160 8 crude crude JJ cord-329844-w969lczb 160 9 rules rule NNS cord-329844-w969lczb 160 10 - - : cord-329844-w969lczb 160 11 of of IN cord-329844-w969lczb 160 12 - - HYPH cord-329844-w969lczb 160 13 thumb thumb NN cord-329844-w969lczb 160 14 : : : cord-329844-w969lczb 160 15 the the DT cord-329844-w969lczb 160 16 best good JJS cord-329844-w969lczb 160 17 replacements replacement NNS cord-329844-w969lczb 160 18 are be VBP cord-329844-w969lczb 160 19 dependent dependent JJ cord-329844-w969lczb 160 20 on on IN cord-329844-w969lczb 160 21 more more RBR cord-329844-w969lczb 160 22 specific specific JJ cord-329844-w969lczb 160 23 circumstances circumstance NNS cord-329844-w969lczb 160 24 and and CC cord-329844-w969lczb 160 25 detailed detail VBN cord-329844-w969lczb 160 26 conformational conformational JJ cord-329844-w969lczb 160 27 and and CC cord-329844-w969lczb 160 28 binding bind VBG cord-329844-w969lczb 160 29 calculations calculation NNS cord-329844-w969lczb 160 30 . . . cord-329844-w969lczb 161 1 The the DT cord-329844-w969lczb 161 2 assignment assignment NN cord-329844-w969lczb 161 3 in in IN cord-329844-w969lczb 161 4 Table Table NNP cord-329844-w969lczb 161 5 1 1 CD cord-329844-w969lczb 161 6 are be VBP cord-329844-w969lczb 161 7 not not RB cord-329844-w969lczb 161 8 seen see VBN cord-329844-w969lczb 161 9 as as IN cord-329844-w969lczb 161 10 controversial controversial JJ cord-329844-w969lczb 161 11 because because IN cord-329844-w969lczb 161 12 apart apart RB cord-329844-w969lczb 161 13 from from IN cord-329844-w969lczb 161 14 the the DT cord-329844-w969lczb 161 15 asymmetry asymmetry NN cord-329844-w969lczb 161 16 they -PRON- PRP cord-329844-w969lczb 161 17 relate relate VBP cord-329844-w969lczb 161 18 to to IN cord-329844-w969lczb 161 19 the the DT cord-329844-w969lczb 161 20 " " `` cord-329844-w969lczb 161 21 interchangability interchangability NN cord-329844-w969lczb 161 22 " " '' cord-329844-w969lczb 161 23 or or CC cord-329844-w969lczb 161 24 " " `` cord-329844-w969lczb 161 25 alternative alternative JJ cord-329844-w969lczb 161 26 rule rule NN cord-329844-w969lczb 161 27 " " '' cord-329844-w969lczb 161 28 of of IN cord-329844-w969lczb 161 29 amino amino NN cord-329844-w969lczb 161 30 acid acid NN cord-329844-w969lczb 161 31 residues residue NNS cord-329844-w969lczb 161 32 by by IN cord-329844-w969lczb 161 33 many many JJ cord-329844-w969lczb 161 34 authors author NNS cord-329844-w969lczb 161 35 that that WDT cord-329844-w969lczb 161 36 are be VBP cord-329844-w969lczb 161 37 intended intend VBN cord-329844-w969lczb 161 38 as as IN cord-329844-w969lczb 161 39 universal universal JJ cord-329844-w969lczb 161 40 , , , cord-329844-w969lczb 161 41 i.e. i.e. FW cord-329844-w969lczb 161 42 intended intend VBN cord-329844-w969lczb 161 43 to to TO cord-329844-w969lczb 161 44 apply apply VB cord-329844-w969lczb 161 45 to to IN cord-329844-w969lczb 161 46 all all DT cord-329844-w969lczb 161 47 proteins protein NNS cord-329844-w969lczb 161 48 . . . cord-329844-w969lczb 162 1 This this DT cord-329844-w969lczb 162 2 is be VBZ cord-329844-w969lczb 162 3 because because IN cord-329844-w969lczb 162 4 they -PRON- PRP cord-329844-w969lczb 162 5 relate relate VBP cord-329844-w969lczb 162 6 to to IN cord-329844-w969lczb 162 7 similarity similarity NN cord-329844-w969lczb 162 8 of of IN cord-329844-w969lczb 162 9 amino amino NN cord-329844-w969lczb 162 10 acid acid NN cord-329844-w969lczb 162 11 residues residue NNS cord-329844-w969lczb 162 12 in in IN cord-329844-w969lczb 162 13 terms term NNS cord-329844-w969lczb 162 14 of of IN cord-329844-w969lczb 162 15 physicochemical physicochemical JJ cord-329844-w969lczb 162 16 , , , cord-329844-w969lczb 162 17 conformational conformational JJ cord-329844-w969lczb 162 18 , , , cord-329844-w969lczb 162 19 as as RB cord-329844-w969lczb 162 20 well well RB cord-329844-w969lczb 162 21 as as IN cord-329844-w969lczb 162 22 biological biological JJ cord-329844-w969lczb 162 23 properties property NNS cord-329844-w969lczb 162 24 of of IN cord-329844-w969lczb 162 25 many many JJ cord-329844-w969lczb 162 26 sequences sequence NNS cord-329844-w969lczb 162 27 that that WDT cord-329844-w969lczb 162 28 are be VBP cord-329844-w969lczb 162 29 at at IN cord-329844-w969lczb 162 30 least least JJS cord-329844-w969lczb 162 31 universal universal JJ cord-329844-w969lczb 162 32 to to TO cord-329844-w969lczb 162 33 , , , cord-329844-w969lczb 162 34 say say UH cord-329844-w969lczb 162 35 , , , cord-329844-w969lczb 162 36 vertebrates vertebrate NNS cord-329844-w969lczb 162 37 . . . cord-329844-w969lczb 163 1 However however RB cord-329844-w969lczb 163 2 , , , cord-329844-w969lczb 163 3 they -PRON- PRP cord-329844-w969lczb 163 4 are be VBP cord-329844-w969lczb 163 5 historically historically RB cord-329844-w969lczb 163 6 more more RBR cord-329844-w969lczb 163 7 directly directly RB cord-329844-w969lczb 163 8 empirically empirically RB cord-329844-w969lczb 163 9 based base VBN cord-329844-w969lczb 163 10 on on IN cord-329844-w969lczb 163 11 wellknown wellknown JJ cord-329844-w969lczb 163 12 studies study NNS cord-329844-w969lczb 163 13 probabilities probability NNS cord-329844-w969lczb 163 14 of of IN cord-329844-w969lczb 163 15 amino amino NN cord-329844-w969lczb 163 16 acid acid JJ cord-329844-w969lczb 163 17 differences difference NNS cord-329844-w969lczb 163 18 found find VBN cord-329844-w969lczb 163 19 by by IN cord-329844-w969lczb 163 20 comparing compare VBG cord-329844-w969lczb 163 21 amino amino NN cord-329844-w969lczb 163 22 acid acid NN cord-329844-w969lczb 163 23 residue residue NN cord-329844-w969lczb 163 24 sequences sequence NNS cord-329844-w969lczb 163 25 amongst amongst IN cord-329844-w969lczb 163 26 fairly fairly RB cord-329844-w969lczb 163 27 related related JJ cord-329844-w969lczb 163 28 proteins protein NNS cord-329844-w969lczb 163 29 from from IN cord-329844-w969lczb 163 30 a a DT cord-329844-w969lczb 163 31 wide wide JJ cord-329844-w969lczb 163 32 range range NN cord-329844-w969lczb 163 33 of of IN cord-329844-w969lczb 163 34 sets set NNS cord-329844-w969lczb 163 35 of of IN cord-329844-w969lczb 163 36 different different JJ cord-329844-w969lczb 163 37 proteins protein NNS cord-329844-w969lczb 163 38 , , , cord-329844-w969lczb 163 39 such such JJ cord-329844-w969lczb 163 40 that that IN cord-329844-w969lczb 163 41 one one NN cord-329844-w969lczb 163 42 is be VBZ cord-329844-w969lczb 163 43 comparing compare VBG cord-329844-w969lczb 163 44 sequences sequence NNS cord-329844-w969lczb 163 45 of of IN cord-329844-w969lczb 163 46 hemoglobins hemoglobin NNS cord-329844-w969lczb 163 47 , , , cord-329844-w969lczb 163 48 or or CC cord-329844-w969lczb 163 49 of of IN cord-329844-w969lczb 163 50 lysozymes lysozyme NNS cord-329844-w969lczb 163 51 , , , cord-329844-w969lczb 163 52 or or CC cord-329844-w969lczb 163 53 of of IN cord-329844-w969lczb 163 54 cytochromes cytochromes NNP cord-329844-w969lczb 163 55 C C NNP cord-329844-w969lczb 163 56 , , , cord-329844-w969lczb 163 57 and and CC cord-329844-w969lczb 163 58 so so RB cord-329844-w969lczb 163 59 on on RB cord-329844-w969lczb 163 60 . . . cord-329844-w969lczb 164 1 As as IN cord-329844-w969lczb 164 2 is be VBZ cord-329844-w969lczb 164 3 to to IN cord-329844-w969lczb 164 4 some some DT cord-329844-w969lczb 164 5 extent extent NN cord-329844-w969lczb 164 6 customary customary JJ cord-329844-w969lczb 164 7 in in IN cord-329844-w969lczb 164 8 the the DT cord-329844-w969lczb 164 9 field field NN cord-329844-w969lczb 164 10 , , , cord-329844-w969lczb 164 11 three three CD cord-329844-w969lczb 164 12 letter letter NN cord-329844-w969lczb 164 13 codes code NNS cord-329844-w969lczb 164 14 ( ( -LRB- cord-329844-w969lczb 164 15 such such JJ cord-329844-w969lczb 164 16 as as IN cord-329844-w969lczb 164 17 GLY GLY NNP cord-329844-w969lczb 164 18 for for IN cord-329844-w969lczb 164 19 glycine glycine NN cord-329844-w969lczb 164 20 ) ) -RRB- cord-329844-w969lczb 164 21 are be VBP cord-329844-w969lczb 164 22 used use VBN cord-329844-w969lczb 164 23 for for IN cord-329844-w969lczb 164 24 the the DT cord-329844-w969lczb 164 25 amino amino NN cord-329844-w969lczb 164 26 acids acid NNS cord-329844-w969lczb 164 27 in in IN cord-329844-w969lczb 164 28 the the DT cord-329844-w969lczb 164 29 molecular molecular JJ cord-329844-w969lczb 164 30 graphics graphic NNS cord-329844-w969lczb 164 31 figures figure NNS cord-329844-w969lczb 164 32 ; ; : cord-329844-w969lczb 164 33 these these DT cord-329844-w969lczb 164 34 codes code NNS cord-329844-w969lczb 164 35 are be VBP cord-329844-w969lczb 164 36 fairly fairly RB cord-329844-w969lczb 164 37 self self NN cord-329844-w969lczb 164 38 - - HYPH cord-329844-w969lczb 164 39 evident evident JJ cord-329844-w969lczb 164 40 at at IN cord-329844-w969lczb 164 41 least least JJS cord-329844-w969lczb 164 42 in in IN cord-329844-w969lczb 164 43 the the DT cord-329844-w969lczb 164 44 direction direction NN cord-329844-w969lczb 164 45 of of IN cord-329844-w969lczb 164 46 deducing deduce VBG cord-329844-w969lczb 164 47 the the DT cord-329844-w969lczb 164 48 full full JJ cord-329844-w969lczb 164 49 name name NN cord-329844-w969lczb 164 50 of of IN cord-329844-w969lczb 164 51 the the DT cord-329844-w969lczb 164 52 amino amino NN cord-329844-w969lczb 164 53 acid acid NN cord-329844-w969lczb 164 54 being be VBG cord-329844-w969lczb 164 55 represented represent VBN cord-329844-w969lczb 164 56 . . . cord-329844-w969lczb 165 1 There there EX cord-329844-w969lczb 165 2 was be VBD cord-329844-w969lczb 165 3 also also RB cord-329844-w969lczb 165 4 use use NN cord-329844-w969lczb 165 5 of of IN cord-329844-w969lczb 165 6 data datum NNS cord-329844-w969lczb 165 7 and and CC cord-329844-w969lczb 165 8 the the DT cord-329844-w969lczb 165 9 associated associate VBN cord-329844-w969lczb 165 10 graphics graphic NNS cord-329844-w969lczb 165 11 tools tool NNS cord-329844-w969lczb 165 12 in in IN cord-329844-w969lczb 165 13 the the DT cord-329844-w969lczb 165 14 Protein Protein NNP cord-329844-w969lczb 165 15 Data Data NNP cord-329844-w969lczb 165 16 Bank Bank NNP cord-329844-w969lczb 165 17 ( ( -LRB- cord-329844-w969lczb 165 18 PDB PDB NNP cord-329844-w969lczb 165 19 ) ) -RRB- cord-329844-w969lczb 165 20 at at IN cord-329844-w969lczb 165 21 https://www.rcsb.org/ https://www.rcsb.org/ ADD cord-329844-w969lczb 165 22 and and CC cord-329844-w969lczb 165 23 in in IN cord-329844-w969lczb 165 24 Japan Japan NNP cord-329844-w969lczb 165 25 https://pdbj.org/ https://pdbj.org/ . cord-329844-w969lczb 165 26 which which WDT cord-329844-w969lczb 165 27 was be VBD cord-329844-w969lczb 165 28 used use VBN cord-329844-w969lczb 165 29 for for IN cord-329844-w969lczb 165 30 Fig Fig NNP cord-329844-w969lczb 165 31 . . . cord-329844-w969lczb 166 1 1 1 LS cord-329844-w969lczb 166 2 . . . cord-329844-w969lczb 166 3 _SP cord-329844-w969lczb 167 1 Energy energy NN cord-329844-w969lczb 167 2 calculations calculation NNS cord-329844-w969lczb 167 3 by by IN cord-329844-w969lczb 167 4 the the DT cord-329844-w969lczb 167 5 author author NN cord-329844-w969lczb 167 6 's 's POS cord-329844-w969lczb 167 7 own own JJ cord-329844-w969lczb 167 8 KRUNCH KRUNCH NNP cord-329844-w969lczb 167 9 and and CC cord-329844-w969lczb 167 10 by by IN cord-329844-w969lczb 167 11 a a DT cord-329844-w969lczb 167 12 commercial commercial JJ cord-329844-w969lczb 167 13 Sculpt sculpt JJ cord-329844-w969lczb 167 14 protein protein NN cord-329844-w969lczb 167 15 modeling modeling NN cord-329844-w969lczb 167 16 package package NN cord-329844-w969lczb 167 17 were be VBD cord-329844-w969lczb 167 18 used use VBN cord-329844-w969lczb 167 19 in in IN cord-329844-w969lczb 167 20 Ref Ref NNP cord-329844-w969lczb 167 21 [ [ -LRB- cord-329844-w969lczb 167 22 4 4 CD cord-329844-w969lczb 167 23 ] ] -RRB- cord-329844-w969lczb 167 24 , , , cord-329844-w969lczb 167 25 but but CC cord-329844-w969lczb 167 26 were be VBD cord-329844-w969lczb 167 27 not not RB cord-329844-w969lczb 167 28 required require VBN cord-329844-w969lczb 167 29 for for IN cord-329844-w969lczb 167 30 the the DT cord-329844-w969lczb 167 31 present present JJ cord-329844-w969lczb 167 32 study study NN cord-329844-w969lczb 167 33 , , , cord-329844-w969lczb 167 34 with with IN cord-329844-w969lczb 167 35 the the DT cord-329844-w969lczb 167 36 exception exception NN cord-329844-w969lczb 167 37 that that IN cord-329844-w969lczb 167 38 some some DT cord-329844-w969lczb 167 39 calculations calculation NNS cord-329844-w969lczb 167 40 by by IN cord-329844-w969lczb 167 41 these these DT cord-329844-w969lczb 167 42 tools tool NNS cord-329844-w969lczb 167 43 were be VBD cord-329844-w969lczb 167 44 used use VBN cord-329844-w969lczb 167 45 to to TO cord-329844-w969lczb 167 46 obtain obtain VB cord-329844-w969lczb 167 47 earlier early RBR cord-329844-w969lczb 167 48 unpublished unpublished JJ cord-329844-w969lczb 167 49 results result NNS cord-329844-w969lczb 167 50 on on IN cord-329844-w969lczb 167 51 sugar sugar NN cord-329844-w969lczb 167 52 binding bind VBG cord-329844-w969lczb 167 53 to to IN cord-329844-w969lczb 167 54 amino amino NN cord-329844-w969lczb 167 55 acid acid NN cord-329844-w969lczb 167 56 residue residue NN cord-329844-w969lczb 167 57 sidechains sidechain NNS cord-329844-w969lczb 167 58 . . . cord-329844-w969lczb 168 1 This this DT cord-329844-w969lczb 168 2 provided provide VBD cord-329844-w969lczb 168 3 a a DT cord-329844-w969lczb 168 4 check check NN cord-329844-w969lczb 168 5 on on IN cord-329844-w969lczb 168 6 the the DT cord-329844-w969lczb 168 7 preliminary preliminary JJ cord-329844-w969lczb 168 8 sialic sialic NN cord-329844-w969lczb 168 9 acid acid NN cord-329844-w969lczb 168 10 binding bind VBG cord-329844-w969lczb 168 11 capability capability NN cord-329844-w969lczb 168 12 shown show VBN cord-329844-w969lczb 168 13 in in IN cord-329844-w969lczb 168 14 column column NN cord-329844-w969lczb 168 15 4 4 CD cord-329844-w969lczb 168 16 of of IN cord-329844-w969lczb 168 17 Table Table NNP cord-329844-w969lczb 168 18 1 1 CD cord-329844-w969lczb 168 19 , , , cord-329844-w969lczb 168 20 used use VBN cord-329844-w969lczb 168 21 initially initially RB cord-329844-w969lczb 168 22 in in IN cord-329844-w969lczb 168 23 the the DT cord-329844-w969lczb 168 24 present present JJ cord-329844-w969lczb 168 25 paper paper NN cord-329844-w969lczb 168 26 . . . cord-329844-w969lczb 169 1 KRUNCH KRUNCH NNP cord-329844-w969lczb 169 2 is be VBZ cord-329844-w969lczb 169 3 a a DT cord-329844-w969lczb 169 4 molecular molecular JJ cord-329844-w969lczb 169 5 mechanics mechanic NNS cord-329844-w969lczb 169 6 modeling modeling NN cord-329844-w969lczb 169 7 package package NN cord-329844-w969lczb 169 8 that that WDT cord-329844-w969lczb 169 9 essentially essentially RB cord-329844-w969lczb 169 10 functions function VBZ cord-329844-w969lczb 169 11 like like IN cord-329844-w969lczb 169 12 many many JJ cord-329844-w969lczb 169 13 standard standard JJ cord-329844-w969lczb 169 14 molecular molecular JJ cord-329844-w969lczb 169 15 modeling modeling NN cord-329844-w969lczb 169 16 packages package NNS cord-329844-w969lczb 169 17 . . . cord-329844-w969lczb 170 1 There there EX cord-329844-w969lczb 170 2 is be VBZ cord-329844-w969lczb 170 3 the the DT cord-329844-w969lczb 170 4 arguable arguable JJ cord-329844-w969lczb 170 5 exception exception NN cord-329844-w969lczb 170 6 that that IN cord-329844-w969lczb 170 7 it -PRON- PRP cord-329844-w969lczb 170 8 gives give VBZ cord-329844-w969lczb 170 9 much much RB cord-329844-w969lczb 170 10 more more JJR cord-329844-w969lczb 170 11 attention attention NN cord-329844-w969lczb 170 12 than than IN cord-329844-w969lczb 170 13 usual usual JJ cord-329844-w969lczb 170 14 to to IN cord-329844-w969lczb 170 15 novel novel JJ cord-329844-w969lczb 170 16 algorithms algorithm NNS cord-329844-w969lczb 170 17 for for IN cord-329844-w969lczb 170 18 navigating navigate VBG cord-329844-w969lczb 170 19 through through IN cord-329844-w969lczb 170 20 multiple multiple JJ cord-329844-w969lczb 170 21 energy energy NN cord-329844-w969lczb 170 22 minima minimum NNS cord-329844-w969lczb 170 23 and and CC cord-329844-w969lczb 170 24 discovering discover VBG cord-329844-w969lczb 170 25 new new JJ cord-329844-w969lczb 170 26 conformers conformer NNS cord-329844-w969lczb 170 27 , , , cord-329844-w969lczb 170 28 but but CC cord-329844-w969lczb 170 29 that that DT cord-329844-w969lczb 170 30 capability capability NN cord-329844-w969lczb 170 31 did do VBD cord-329844-w969lczb 170 32 not not RB cord-329844-w969lczb 170 33 appear appear VB cord-329844-w969lczb 170 34 to to TO cord-329844-w969lczb 170 35 be be VB cord-329844-w969lczb 170 36 too too RB cord-329844-w969lczb 170 37 important important JJ cord-329844-w969lczb 170 38 in in IN cord-329844-w969lczb 170 39 the the DT cord-329844-w969lczb 170 40 present present JJ cord-329844-w969lczb 170 41 study study NN cord-329844-w969lczb 170 42 . . . cord-329844-w969lczb 171 1 For for IN cord-329844-w969lczb 171 2 the the DT cord-329844-w969lczb 171 3 much much RB cord-329844-w969lczb 171 4 greater great JJR cord-329844-w969lczb 171 5 part part NN cord-329844-w969lczb 171 6 , , , cord-329844-w969lczb 171 7 however however RB cord-329844-w969lczb 171 8 , , , cord-329844-w969lczb 171 9 these these DT cord-329844-w969lczb 171 10 binding bind VBG cord-329844-w969lczb 171 11 assessments assessment NNS cord-329844-w969lczb 171 12 were be VBD cord-329844-w969lczb 171 13 based base VBN cord-329844-w969lczb 171 14 on on IN cord-329844-w969lczb 171 15 the the DT cord-329844-w969lczb 171 16 amino amino NN cord-329844-w969lczb 171 17 acid acid NN cord-329844-w969lczb 171 18 residues residue NNS cord-329844-w969lczb 171 19 observed observe VBN cord-329844-w969lczb 171 20 by by IN cord-329844-w969lczb 171 21 the the DT cord-329844-w969lczb 171 22 author author NN cord-329844-w969lczb 171 23 in in IN cord-329844-w969lczb 171 24 sequences sequence NNS cord-329844-w969lczb 171 25 involved involve VBN cord-329844-w969lczb 171 26 in in IN cord-329844-w969lczb 171 27 sugar sugar NN cord-329844-w969lczb 171 28 binding bind VBG cord-329844-w969lczb 171 29 sites site NNS cord-329844-w969lczb 171 30 in in IN cord-329844-w969lczb 171 31 proteins protein NNS cord-329844-w969lczb 171 32 ( ( -LRB- cord-329844-w969lczb 171 33 found find VBN cord-329844-w969lczb 171 34 by by IN cord-329844-w969lczb 171 35 visual visual JJ cord-329844-w969lczb 171 36 examination examination NN cord-329844-w969lczb 171 37 of of IN cord-329844-w969lczb 171 38 binding bind VBG cord-329844-w969lczb 171 39 sites site NNS cord-329844-w969lczb 171 40 of of IN cord-329844-w969lczb 171 41 entries entry NNS cord-329844-w969lczb 171 42 in in IN cord-329844-w969lczb 171 43 the the DT cord-329844-w969lczb 171 44 PDB PDB NNP cord-329844-w969lczb 171 45 ) ) -RRB- cord-329844-w969lczb 171 46 and and CC cord-329844-w969lczb 171 47 similar similar JJ cord-329844-w969lczb 171 48 qualitative qualitative JJ cord-329844-w969lczb 171 49 observations observation NNS cord-329844-w969lczb 171 50 by by IN cord-329844-w969lczb 171 51 other other JJ cord-329844-w969lczb 171 52 authors author NNS cord-329844-w969lczb 171 53 . . . cord-329844-w969lczb 172 1 That that RB cord-329844-w969lczb 172 2 is is RB cord-329844-w969lczb 172 3 , , , cord-329844-w969lczb 172 4 they -PRON- PRP cord-329844-w969lczb 172 5 also also RB cord-329844-w969lczb 172 6 reflect reflect VBP cord-329844-w969lczb 172 7 rather rather RB cord-329844-w969lczb 172 8 general general JJ cord-329844-w969lczb 172 9 opinion opinion NN cord-329844-w969lczb 172 10 of of IN cord-329844-w969lczb 172 11 what what WP cord-329844-w969lczb 172 12 amino amino JJ cord-329844-w969lczb 172 13 acids acid NNS cord-329844-w969lczb 172 14 are be VBP cord-329844-w969lczb 172 15 involved involve VBN cord-329844-w969lczb 172 16 in in IN cord-329844-w969lczb 172 17 sugar sugar NN cord-329844-w969lczb 172 18 binding binding NN cord-329844-w969lczb 172 19 and and CC cord-329844-w969lczb 173 1 in in IN cord-329844-w969lczb 173 2 its -PRON- PRP$ cord-329844-w969lczb 173 3 most most RBS cord-329844-w969lczb 173 4 general general JJ cord-329844-w969lczb 173 5 formulation formulation NN cord-329844-w969lczb 173 6 this this DT cord-329844-w969lczb 173 7 intuitively intuitively RB cord-329844-w969lczb 173 8 comprises comprise VBZ cord-329844-w969lczb 173 9 aromatic aromatic JJ cord-329844-w969lczb 173 10 residues residue NNS cord-329844-w969lczb 173 11 , , , cord-329844-w969lczb 173 12 and and CC cord-329844-w969lczb 173 13 hydrogen hydrogen NN cord-329844-w969lczb 173 14 bonding bonding NN cord-329844-w969lczb 173 15 residues residue NNS cord-329844-w969lczb 173 16 to to TO cord-329844-w969lczb 173 17 interact interact VB cord-329844-w969lczb 173 18 with with IN cord-329844-w969lczb 173 19 the the DT cord-329844-w969lczb 173 20 sugar sugar NN cord-329844-w969lczb 173 21 hydroxyl hydroxyl NN cord-329844-w969lczb 173 22 groups group NNS cord-329844-w969lczb 173 23 . . . cord-329844-w969lczb 174 1 At at IN cord-329844-w969lczb 174 2 the the DT cord-329844-w969lczb 174 3 outset outset NN cord-329844-w969lczb 174 4 , , , cord-329844-w969lczb 174 5 as as IN cord-329844-w969lczb 174 6 a a DT cord-329844-w969lczb 174 7 starting starting NN cord-329844-w969lczb 174 8 point point NN cord-329844-w969lczb 174 9 only only RB cord-329844-w969lczb 174 10 , , , cord-329844-w969lczb 174 11 column column NN cord-329844-w969lczb 174 12 4 4 CD cord-329844-w969lczb 174 13 of of IN cord-329844-w969lczb 174 14 Table Table NNP cord-329844-w969lczb 174 15 1 1 CD cord-329844-w969lczb 174 16 of of IN cord-329844-w969lczb 174 17 these these DT cord-329844-w969lczb 174 18 preliminary preliminary JJ cord-329844-w969lczb 174 19 sialic sialic NN cord-329844-w969lczb 174 20 acid acid NN cord-329844-w969lczb 174 21 binding bind VBG cord-329844-w969lczb 174 22 amino amino NN cord-329844-w969lczb 174 23 acid acid NN cord-329844-w969lczb 174 24 scores score NNS cord-329844-w969lczb 174 25 ( ( -LRB- cord-329844-w969lczb 174 26 SABS SABS NNP cord-329844-w969lczb 174 27 ) ) -RRB- cord-329844-w969lczb 174 28 are be VBP cord-329844-w969lczb 174 29 really really RB cord-329844-w969lczb 174 30 assignments assignment NNS cord-329844-w969lczb 174 31 that that WDT cord-329844-w969lczb 174 32 are be VBP cord-329844-w969lczb 174 33 qualitative qualitative JJ cord-329844-w969lczb 174 34 , , , cord-329844-w969lczb 174 35 using use VBG cord-329844-w969lczb 174 36 0 0 CD cord-329844-w969lczb 174 37 for for IN cord-329844-w969lczb 174 38 not not RB cord-329844-w969lczb 174 39 often often RB cord-329844-w969lczb 174 40 present present JJ cord-329844-w969lczb 174 41 in in IN cord-329844-w969lczb 174 42 sialic sialic JJ cord-329844-w969lczb 174 43 acid acid NN cord-329844-w969lczb 174 44 glycan glycan NN cord-329844-w969lczb 174 45 binding bind VBG cord-329844-w969lczb 174 46 sites site NNS cord-329844-w969lczb 174 47 and and CC cord-329844-w969lczb 174 48 1 1 CD cord-329844-w969lczb 174 49 for for IN cord-329844-w969lczb 174 50 often often RB cord-329844-w969lczb 174 51 present present JJ cord-329844-w969lczb 174 52 , , , cord-329844-w969lczb 174 53 . . . cord-329844-w969lczb 175 1 However however RB cord-329844-w969lczb 175 2 , , , cord-329844-w969lczb 175 3 tryptophan tryptophan NN cord-329844-w969lczb 175 4 was be VBD cord-329844-w969lczb 175 5 assigned assign VBN cord-329844-w969lczb 175 6 a a DT cord-329844-w969lczb 175 7 double double JJ cord-329844-w969lczb 175 8 score score NN cord-329844-w969lczb 175 9 of of IN cord-329844-w969lczb 175 10 2 2 CD cord-329844-w969lczb 175 11 reflecting reflect VBG cord-329844-w969lczb 175 12 its -PRON- PRP$ cord-329844-w969lczb 175 13 larger large JJR cord-329844-w969lczb 175 14 size size NN cord-329844-w969lczb 175 15 and and CC cord-329844-w969lczb 175 16 double double JJ cord-329844-w969lczb 175 17 ring ring NN cord-329844-w969lczb 175 18 . . . cord-329844-w969lczb 176 1 How how WRB cord-329844-w969lczb 176 2 reliable reliable JJ cord-329844-w969lczb 176 3 these these DT cord-329844-w969lczb 176 4 assignments assignment NNS cord-329844-w969lczb 176 5 are be VBP cord-329844-w969lczb 176 6 in in IN cord-329844-w969lczb 176 7 regard regard NN cord-329844-w969lczb 176 8 to to IN cord-329844-w969lczb 176 9 sialic sialic JJ cord-329844-w969lczb 176 10 acid acid NN cord-329844-w969lczb 176 11 glycan glycan NN cord-329844-w969lczb 176 12 binding binding NN cord-329844-w969lczb 176 13 is be VBZ cord-329844-w969lczb 176 14 what what WP cord-329844-w969lczb 176 15 is be VBZ cord-329844-w969lczb 176 16 assessed assess VBN cord-329844-w969lczb 176 17 on on IN cord-329844-w969lczb 176 18 a a DT cord-329844-w969lczb 176 19 more more RBR cord-329844-w969lczb 176 20 objective objective JJ cord-329844-w969lczb 176 21 basis basis NN cord-329844-w969lczb 176 22 by by IN cord-329844-w969lczb 176 23 the the DT cord-329844-w969lczb 176 24 prediction prediction NN cord-329844-w969lczb 176 25 method method NN cord-329844-w969lczb 176 26 developed develop VBN cord-329844-w969lczb 176 27 in in IN cord-329844-w969lczb 176 28 this this DT cord-329844-w969lczb 176 29 paper paper NN cord-329844-w969lczb 176 30 , , , cord-329844-w969lczb 176 31 including include VBG cord-329844-w969lczb 176 32 a a DT cord-329844-w969lczb 176 33 degree degree NN cord-329844-w969lczb 176 34 of of IN cord-329844-w969lczb 176 35 recalibration recalibration NN cord-329844-w969lczb 176 36 . . . cord-329844-w969lczb 177 1 The the DT cord-329844-w969lczb 177 2 marginally marginally RB cord-329844-w969lczb 177 3 modified modify VBN cord-329844-w969lczb 177 4 parameters parameter NNS cord-329844-w969lczb 177 5 are be VBP cord-329844-w969lczb 177 6 also also RB cord-329844-w969lczb 177 7 shown show VBN cord-329844-w969lczb 177 8 in in IN cord-329844-w969lczb 177 9 the the DT cord-329844-w969lczb 177 10 last last JJ cord-329844-w969lczb 177 11 column column NN cord-329844-w969lczb 177 12 Table table NN cord-329844-w969lczb 177 13 1 1 CD cord-329844-w969lczb 177 14 for for IN cord-329844-w969lczb 177 15 convenience convenience NN cord-329844-w969lczb 177 16 of of IN cord-329844-w969lczb 177 17 comparison comparison NN cord-329844-w969lczb 177 18 . . . cord-329844-w969lczb 178 1 While while IN cord-329844-w969lczb 178 2 as as IN cord-329844-w969lczb 178 3 a a DT cord-329844-w969lczb 178 4 methodological methodological JJ cord-329844-w969lczb 178 5 strategy strategy NN cord-329844-w969lczb 178 6 it -PRON- PRP cord-329844-w969lczb 178 7 was be VBD cord-329844-w969lczb 178 8 tempting tempt VBG cord-329844-w969lczb 178 9 to to TO cord-329844-w969lczb 178 10 start start VB cord-329844-w969lczb 178 11 from from IN cord-329844-w969lczb 178 12 an an DT cord-329844-w969lczb 178 13 alternative alternative JJ cord-329844-w969lczb 178 14 more more RBR cord-329844-w969lczb 178 15 objective objective JJ cord-329844-w969lczb 178 16 and and CC cord-329844-w969lczb 178 17 established established JJ cord-329844-w969lczb 178 18 approach approach NN cord-329844-w969lczb 178 19 discussed discuss VBN cord-329844-w969lczb 178 20 in in IN cord-329844-w969lczb 178 21 Results Results NNP cord-329844-w969lczb 178 22 Section Section NNP cord-329844-w969lczb 178 23 4 4 CD cord-329844-w969lczb 178 24 , , , cord-329844-w969lczb 178 25 or or CC cord-329844-w969lczb 178 26 at at IN cord-329844-w969lczb 178 27 least least JJS cord-329844-w969lczb 178 28 to to TO cord-329844-w969lczb 178 29 use use VB cord-329844-w969lczb 178 30 it -PRON- PRP cord-329844-w969lczb 178 31 as as IN cord-329844-w969lczb 178 32 a a DT cord-329844-w969lczb 178 33 starting starting NN cord-329844-w969lczb 178 34 point point NN cord-329844-w969lczb 178 35 or or CC cord-329844-w969lczb 178 36 as as IN cord-329844-w969lczb 178 37 an an DT cord-329844-w969lczb 178 38 important important JJ cord-329844-w969lczb 178 39 " " `` cord-329844-w969lczb 178 40 gold gold NN cord-329844-w969lczb 178 41 standard standard NN cord-329844-w969lczb 178 42 " " '' cord-329844-w969lczb 178 43 for for IN cord-329844-w969lczb 178 44 comparison comparison NN cord-329844-w969lczb 178 45 , , , cord-329844-w969lczb 178 46 it -PRON- PRP cord-329844-w969lczb 178 47 has have VBZ cord-329844-w969lczb 178 48 substantially substantially RB cord-329844-w969lczb 178 49 different different JJ cord-329844-w969lczb 178 50 aims aim NNS cord-329844-w969lczb 178 51 . . . cord-329844-w969lczb 179 1 As as IN cord-329844-w969lczb 179 2 a a DT cord-329844-w969lczb 179 3 first first JJ cord-329844-w969lczb 179 4 step step NN cord-329844-w969lczb 179 5 in in IN cord-329844-w969lczb 179 6 an an DT cord-329844-w969lczb 179 7 investigation investigation NN cord-329844-w969lczb 179 8 making make VBG cord-329844-w969lczb 179 9 use use NN cord-329844-w969lczb 179 10 of of IN cord-329844-w969lczb 179 11 bioinformatics bioinformatic NNS cord-329844-w969lczb 179 12 , , , cord-329844-w969lczb 179 13 a a DT cord-329844-w969lczb 179 14 common common JJ cord-329844-w969lczb 179 15 strategy strategy NN cord-329844-w969lczb 179 16 is be VBZ cord-329844-w969lczb 179 17 the the DT cord-329844-w969lczb 179 18 use use NN cord-329844-w969lczb 179 19 of of IN cord-329844-w969lczb 179 20 protein protein NN cord-329844-w969lczb 179 21 sequence sequence NN cord-329844-w969lczb 179 22 alignments alignment NNS cord-329844-w969lczb 179 23 so so IN cord-329844-w969lczb 179 24 that that IN cord-329844-w969lczb 179 25 a a DT cord-329844-w969lczb 179 26 functional functional JJ cord-329844-w969lczb 179 27 part part NN cord-329844-w969lczb 179 28 that that WDT cord-329844-w969lczb 179 29 is be VBZ cord-329844-w969lczb 179 30 known know VBN cord-329844-w969lczb 179 31 in in IN cord-329844-w969lczb 179 32 one one CD cord-329844-w969lczb 179 33 protein protein NN cord-329844-w969lczb 179 34 might may MD cord-329844-w969lczb 179 35 suggest suggest VB cord-329844-w969lczb 179 36 an an DT cord-329844-w969lczb 179 37 analogous analogous JJ cord-329844-w969lczb 179 38 functional functional JJ cord-329844-w969lczb 179 39 part part NN cord-329844-w969lczb 179 40 in in IN cord-329844-w969lczb 179 41 another another DT cord-329844-w969lczb 179 42 . . . cord-329844-w969lczb 180 1 As as IN cord-329844-w969lczb 180 2 discussed discuss VBN cord-329844-w969lczb 180 3 here here RB cord-329844-w969lczb 180 4 , , , cord-329844-w969lczb 180 5 this this DT cord-329844-w969lczb 180 6 approach approach NN cord-329844-w969lczb 180 7 has have VBZ cord-329844-w969lczb 180 8 proven prove VBN cord-329844-w969lczb 180 9 somewhat somewhat RB cord-329844-w969lczb 180 10 less less RBR cord-329844-w969lczb 180 11 successful successful JJ cord-329844-w969lczb 180 12 for for IN cord-329844-w969lczb 180 13 sialic sialic JJ cord-329844-w969lczb 180 14 acid acid NN cord-329844-w969lczb 180 15 glycan glycan NN cord-329844-w969lczb 180 16 binding bind VBG cord-329844-w969lczb 180 17 sites site NNS cord-329844-w969lczb 180 18 than than IN cord-329844-w969lczb 180 19 for for IN cord-329844-w969lczb 180 20 other other JJ cord-329844-w969lczb 180 21 functions function NNS cord-329844-w969lczb 180 22 considered consider VBN cord-329844-w969lczb 180 23 elsewhere elsewhere RB cord-329844-w969lczb 180 24 ( ( -LRB- cord-329844-w969lczb 180 25 e.g. e.g. IN cord-329844-w969lczb 180 26 refs ref NNS cord-329844-w969lczb 180 27 [ [ -LRB- cord-329844-w969lczb 180 28 3 3 CD cord-329844-w969lczb 180 29 ] ] -RRB- cord-329844-w969lczb 180 30 [ [ -LRB- cord-329844-w969lczb 180 31 4 4 CD cord-329844-w969lczb 180 32 ] ] -RRB- cord-329844-w969lczb 180 33 [ [ -LRB- cord-329844-w969lczb 180 34 5 5 CD cord-329844-w969lczb 180 35 ] ] -RRB- cord-329844-w969lczb 180 36 ) ) -RRB- cord-329844-w969lczb 180 37 , , , cord-329844-w969lczb 180 38 and and CC cord-329844-w969lczb 180 39 necessitated necessitate VBD cord-329844-w969lczb 180 40 development development NN cord-329844-w969lczb 180 41 of of IN cord-329844-w969lczb 180 42 alternative alternative JJ cord-329844-w969lczb 180 43 techniques technique NNS cord-329844-w969lczb 180 44 of of IN cord-329844-w969lczb 180 45 which which WDT cord-329844-w969lczb 180 46 discussion discussion NN cord-329844-w969lczb 180 47 occupies occupy VBZ cord-329844-w969lczb 180 48 the the DT cord-329844-w969lczb 180 49 major major JJ cord-329844-w969lczb 180 50 part part NN cord-329844-w969lczb 180 51 of of IN cord-329844-w969lczb 180 52 this this DT cord-329844-w969lczb 180 53 paper paper NN cord-329844-w969lczb 180 54 , , , cord-329844-w969lczb 180 55 but but CC cord-329844-w969lczb 180 56 the the DT cord-329844-w969lczb 180 57 results result NNS cord-329844-w969lczb 180 58 are be VBP cord-329844-w969lczb 180 59 consistent consistent JJ cord-329844-w969lczb 180 60 and and CC cord-329844-w969lczb 180 61 to to IN cord-329844-w969lczb 180 62 some some DT cord-329844-w969lczb 180 63 degree degree NN cord-329844-w969lczb 180 64 suportive suportive JJ cord-329844-w969lczb 180 65 . . . cord-329844-w969lczb 181 1 As as IN cord-329844-w969lczb 181 2 the the DT cord-329844-w969lczb 181 3 basis basis NN cord-329844-w969lczb 181 4 of of IN cord-329844-w969lczb 181 5 discussion discussion NN cord-329844-w969lczb 181 6 and and CC cord-329844-w969lczb 181 7 starting starting NN cord-329844-w969lczb 181 8 point point NN cord-329844-w969lczb 181 9 for for IN cord-329844-w969lczb 181 10 the the DT cord-329844-w969lczb 181 11 present present JJ cord-329844-w969lczb 181 12 study study NN cord-329844-w969lczb 181 13 , , , cord-329844-w969lczb 181 14 the the DT cord-329844-w969lczb 181 15 following follow VBG cord-329844-w969lczb 181 16 is be VBZ cord-329844-w969lczb 181 17 a a DT cord-329844-w969lczb 181 18 SARS SARS NNP cord-329844-w969lczb 181 19 - - HYPH cord-329844-w969lczb 181 20 CoV-2 CoV-2 NNP cord-329844-w969lczb 181 21 spike spike NN cord-329844-w969lczb 181 22 protein protein NN cord-329844-w969lczb 181 23 sequence sequence NN cord-329844-w969lczb 181 24 in in IN cord-329844-w969lczb 181 25 which which WDT cord-329844-w969lczb 181 26 the the DT cord-329844-w969lczb 181 27 S1-NTD S1-NTD NNP cord-329844-w969lczb 181 28 is be VBZ cord-329844-w969lczb 181 29 shown show VBN cord-329844-w969lczb 181 30 in in IN cord-329844-w969lczb 181 31 italics italic NNS cord-329844-w969lczb 181 32 . . . cord-329844-w969lczb 182 1 The the DT cord-329844-w969lczb 182 2 short short JJ cord-329844-w969lczb 182 3 section section NN cord-329844-w969lczb 182 4 of of IN cord-329844-w969lczb 182 5 sequence sequence NN cord-329844-w969lczb 182 6 underline underline NN cord-329844-w969lczb 182 7 emerges emerge VBZ cord-329844-w969lczb 182 8 below below RB cord-329844-w969lczb 182 9 as as IN cord-329844-w969lczb 182 10 of of IN cord-329844-w969lczb 182 11 particular particular JJ cord-329844-w969lczb 182 12 , , , cord-329844-w969lczb 182 13 but but CC cord-329844-w969lczb 182 14 by by IN cord-329844-w969lczb 182 15 no no DT cord-329844-w969lczb 182 16 means means NN cord-329844-w969lczb 182 17 sole sole JJ cord-329844-w969lczb 182 18 , , , cord-329844-w969lczb 182 19 interest interest NN cord-329844-w969lczb 182 20 . . . cord-329844-w969lczb 183 1 More more RBR cord-329844-w969lczb 183 2 subtle subtle JJ cord-329844-w969lczb 183 3 computational computational JJ cord-329844-w969lczb 183 4 techniques technique NNS cord-329844-w969lczb 183 5 based base VBN cord-329844-w969lczb 183 6 on on IN cord-329844-w969lczb 183 7 protein protein NN cord-329844-w969lczb 183 8 conformation conformation NN cord-329844-w969lczb 183 9 have have VBP cord-329844-w969lczb 183 10 in in IN cord-329844-w969lczb 183 11 this this DT cord-329844-w969lczb 183 12 project project NN cord-329844-w969lczb 183 13 suggested suggest VBD cord-329844-w969lczb 183 14 relationships relationship NNS cord-329844-w969lczb 183 15 between between IN cord-329844-w969lczb 183 16 SARS SARS NNP cord-329844-w969lczb 183 17 - - HYPH cord-329844-w969lczb 183 18 CoV CoV NNP cord-329844-w969lczb 183 19 and and CC cord-329844-w969lczb 183 20 hemagglutinins hemagglutinins NNP cord-329844-w969lczb 183 21 and and CC cord-329844-w969lczb 183 22 neuraminidases neuraminidase NNS cord-329844-w969lczb 183 23 of of IN cord-329844-w969lczb 183 24 other other JJ cord-329844-w969lczb 183 25 viruses virus NNS cord-329844-w969lczb 183 26 , , , cord-329844-w969lczb 183 27 but but CC cord-329844-w969lczb 183 28 they -PRON- PRP cord-329844-w969lczb 183 29 essentially essentially RB cord-329844-w969lczb 183 30 support support VBP cord-329844-w969lczb 183 31 prior prior JJ cord-329844-w969lczb 183 32 work work NN cord-329844-w969lczb 183 33 . . . cord-329844-w969lczb 184 1 Recall recall VB cord-329844-w969lczb 184 2 that that IN cord-329844-w969lczb 184 3 Zhang Zhang NNP cord-329844-w969lczb 184 4 and and CC cord-329844-w969lczb 184 5 Yap Yap NNP cord-329844-w969lczb 184 6 [ [ -LRB- cord-329844-w969lczb 184 7 13 13 CD cord-329844-w969lczb 184 8 ] ] -RRB- cord-329844-w969lczb 184 9 noted note VBD cord-329844-w969lczb 184 10 a a DT cord-329844-w969lczb 184 11 suggestive suggestive JJ cord-329844-w969lczb 184 12 structure structure NN cord-329844-w969lczb 184 13 similarity similarity NN cord-329844-w969lczb 184 14 between between IN cord-329844-w969lczb 184 15 SARS SARS NNP cord-329844-w969lczb 184 16 - - HYPH cord-329844-w969lczb 184 17 CoV CoV NNP cord-329844-w969lczb 184 18 S1 S1 NNP cord-329844-w969lczb 184 19 and and CC cord-329844-w969lczb 184 20 influenza influenza NN cord-329844-w969lczb 184 21 virus virus NN cord-329844-w969lczb 184 22 neuraminidase neuraminidase NN cord-329844-w969lczb 184 23 . . . cord-329844-w969lczb 185 1 Using use VBG cord-329844-w969lczb 185 2 various various JJ cord-329844-w969lczb 185 3 computational computational JJ cord-329844-w969lczb 185 4 techniques technique NNS cord-329844-w969lczb 185 5 they -PRON- PRP cord-329844-w969lczb 185 6 compared compare VBD cord-329844-w969lczb 185 7 the the DT cord-329844-w969lczb 185 8 3D 3d JJ cord-329844-w969lczb 185 9 structure structure NN cord-329844-w969lczb 185 10 of of IN cord-329844-w969lczb 185 11 SARS SARS NNP cord-329844-w969lczb 185 12 - - HYPH cord-329844-w969lczb 185 13 CoV CoV NNP cord-329844-w969lczb 185 14 S1 S1 NNP cord-329844-w969lczb 185 15 Protein Protein NNP cord-329844-w969lczb 185 16 Data Data NNP cord-329844-w969lczb 185 17 Bank Bank NNP cord-329844-w969lczb 185 18 3D 3d JJ cord-329844-w969lczb 185 19 structures structure NNS cord-329844-w969lczb 185 20 1INY 1iny CD cord-329844-w969lczb 186 1 ( ( -LRB- cord-329844-w969lczb 186 2 neuraminidase neuraminidase NN cord-329844-w969lczb 186 3 from from IN cord-329844-w969lczb 186 4 influenza influenza NN cord-329844-w969lczb 186 5 A a DT cord-329844-w969lczb 186 6 virus virus NN cord-329844-w969lczb 186 7 complexed complexe VBN cord-329844-w969lczb 186 8 with with IN cord-329844-w969lczb 186 9 a a DT cord-329844-w969lczb 186 10 sialic sialic JJ cord-329844-w969lczb 186 11 acid acid NN cord-329844-w969lczb 186 12 phosphonate phosphonate NNP cord-329844-w969lczb 186 13 analogue analogue JJ cord-329844-w969lczb 186 14 inhibitor inhibitor NN cord-329844-w969lczb 186 15 ) ) -RRB- cord-329844-w969lczb 186 16 and and CC cord-329844-w969lczb 186 17 1B9 1b9 CD cord-329844-w969lczb 186 18 T t NN cord-329844-w969lczb 186 19 ( ( -LRB- cord-329844-w969lczb 186 20 neuraminidase neuraminidase NN cord-329844-w969lczb 186 21 from from IN cord-329844-w969lczb 186 22 influenza influenza NN cord-329844-w969lczb 186 23 B B NNP cord-329844-w969lczb 186 24 virus virus NN cord-329844-w969lczb 186 25 with with IN cord-329844-w969lczb 186 26 novel novel JJ cord-329844-w969lczb 186 27 aromatic aromatic JJ cord-329844-w969lczb 186 28 inhibitors inhibitor NNS cord-329844-w969lczb 186 29 ) ) -RRB- cord-329844-w969lczb 186 30 . . . cord-329844-w969lczb 187 1 This this DT cord-329844-w969lczb 187 2 observation observation NN cord-329844-w969lczb 187 3 does do VBZ cord-329844-w969lczb 187 4 not not RB cord-329844-w969lczb 187 5 necessarily necessarily RB cord-329844-w969lczb 187 6 suggest suggest VB cord-329844-w969lczb 187 7 by by IN cord-329844-w969lczb 187 8 itself -PRON- PRP cord-329844-w969lczb 187 9 a a DT cord-329844-w969lczb 187 10 common common JJ cord-329844-w969lczb 187 11 function function NN cord-329844-w969lczb 187 12 , , , cord-329844-w969lczb 187 13 because because IN cord-329844-w969lczb 187 14 many many JJ cord-329844-w969lczb 187 15 protein protein NN cord-329844-w969lczb 187 16 folding folding NN cord-329844-w969lczb 187 17 patterns pattern NNS cord-329844-w969lczb 187 18 are be VBP cord-329844-w969lczb 187 19 used use VBN cord-329844-w969lczb 187 20 by by IN cord-329844-w969lczb 187 21 nature nature NN cord-329844-w969lczb 187 22 for for IN cord-329844-w969lczb 187 23 diverse diverse JJ cord-329844-w969lczb 187 24 purposes purpose NNS cord-329844-w969lczb 187 25 , , , cord-329844-w969lczb 187 26 but but CC cord-329844-w969lczb 187 27 armed arm VBN cord-329844-w969lczb 187 28 with with IN cord-329844-w969lczb 187 29 that that DT cord-329844-w969lczb 187 30 information information NN cord-329844-w969lczb 187 31 a a DT cord-329844-w969lczb 187 32 more more RBR cord-329844-w969lczb 187 33 careful careful JJ cord-329844-w969lczb 187 34 use use NN cord-329844-w969lczb 187 35 of of IN cord-329844-w969lczb 187 36 sequence sequence NN cord-329844-w969lczb 187 37 alignment alignment NN cord-329844-w969lczb 187 38 is be VBZ cord-329844-w969lczb 187 39 helpful helpful JJ cord-329844-w969lczb 187 40 . . . cord-329844-w969lczb 188 1 The the DT cord-329844-w969lczb 188 2 following following JJ cord-329844-w969lczb 188 3 part part NN cord-329844-w969lczb 188 4 of of IN cord-329844-w969lczb 188 5 a a DT cord-329844-w969lczb 188 6 Clustalw Clustalw NNP cord-329844-w969lczb 188 7 sequence sequence NN cord-329844-w969lczb 188 8 alignment alignment NN cord-329844-w969lczb 188 9 done do VBN cord-329844-w969lczb 188 10 in in IN cord-329844-w969lczb 188 11 the the DT cord-329844-w969lczb 188 12 present present JJ cord-329844-w969lczb 188 13 study study NN cord-329844-w969lczb 188 14 also also RB cord-329844-w969lczb 188 15 includes include VBZ cord-329844-w969lczb 188 16 the the DT cord-329844-w969lczb 188 17 hemagglutinin hemagglutinin NN cord-329844-w969lczb 188 18 esterase esterase NN cord-329844-w969lczb 188 19 sites site NNS cord-329844-w969lczb 188 20 in in IN cord-329844-w969lczb 188 21 E3 E3 NNP cord-329844-w969lczb 188 22 of of IN cord-329844-w969lczb 188 23 the the DT cord-329844-w969lczb 188 24 bovine bovine JJ cord-329844-w969lczb 188 25 coronavirus coronavirus NN cord-329844-w969lczb 188 26 [ [ -LRB- cord-329844-w969lczb 188 27 8 8 CD cord-329844-w969lczb 188 28 ] ] -RRB- cord-329844-w969lczb 188 29 ( ( -LRB- cord-329844-w969lczb 188 30 E3-CoV E3-CoV NNP cord-329844-w969lczb 188 31 - - HYPH cord-329844-w969lczb 188 32 Q14EB1.1 Q14EB1.1 NNS cord-329844-w969lczb 188 33 below below RB cord-329844-w969lczb 188 34 ) ) -RRB- cord-329844-w969lczb 189 1 and and CC cord-329844-w969lczb 189 2 that that DT cord-329844-w969lczb 189 3 studied study VBN cord-329844-w969lczb 189 4 by by IN cord-329844-w969lczb 189 5 Zeng Zeng NNP cord-329844-w969lczb 189 6 et et NNP cord-329844-w969lczb 189 7 al al NNP cord-329844-w969lczb 189 8 . . . cord-329844-w969lczb 190 1 [ [ -LRB- cord-329844-w969lczb 190 2 9 9 CD cord-329844-w969lczb 190 3 ] ] -RRB- cord-329844-w969lczb 191 1 ( ( -LRB- cord-329844-w969lczb 191 2 Hem Hem NNP cord-329844-w969lczb 191 3 - - HYPH cord-329844-w969lczb 191 4 est est NNP cord-329844-w969lczb 191 5 - - HYPH cord-329844-w969lczb 191 6 CoV-3CL5 CoV-3CL5 NNP cord-329844-w969lczb 191 7 below below RB cord-329844-w969lczb 191 8 ) ) -RRB- cord-329844-w969lczb 191 9 . . . cord-329844-w969lczb 192 1 Substrate substrate NN cord-329844-w969lczb 192 2 binding bind VBG cord-329844-w969lczb 192 3 residues residue NNS cord-329844-w969lczb 192 4 in in IN cord-329844-w969lczb 192 5 deduced deduce VBN cord-329844-w969lczb 192 6 for for IN cord-329844-w969lczb 192 7 SARS SARS NNP cord-329844-w969lczb 192 8 - - HYPH cord-329844-w969lczb 192 9 CoV CoV NNP cord-329844-w969lczb 192 10 S1 s1 NN cord-329844-w969lczb 192 11 by by IN cord-329844-w969lczb 192 12 Zhan Zhan NNP cord-329844-w969lczb 192 13 and and CC cord-329844-w969lczb 192 14 Yap Yap NNP cord-329844-w969lczb 192 15 [ [ -LRB- cord-329844-w969lczb 192 16 13 13 CD cord-329844-w969lczb 192 17 ] ] -RRB- cord-329844-w969lczb 192 18 are be VBP cord-329844-w969lczb 192 19 shown show VBN cord-329844-w969lczb 192 20 by by IN cord-329844-w969lczb 192 21 # # NN cord-329844-w969lczb 192 22 . . . cord-329844-w969lczb 192 23 : : : cord-329844-w969lczb 193 1 : : : cord-329844-w969lczb 193 2 . . . cord-329844-w969lczb 193 3 . . . cord-329844-w969lczb 194 1 * * NFP cord-329844-w969lczb 194 2 : : : cord-329844-w969lczb 194 3 . . . cord-329844-w969lczb 195 1 : : : cord-329844-w969lczb 195 2 : : : cord-329844-w969lczb 195 3 . . . cord-329844-w969lczb 196 1 : : : cord-329844-w969lczb 197 1 * * NFP cord-329844-w969lczb 197 2 . . . cord-329844-w969lczb 198 1 ---QIIFYEGVNFNPHHRF------KCFFNGSNDVWIFNKVRFYRALYSNMALFRYLTFV ---QIIFYEGVNFNPHHRF------KCFFNGSNDVWIFNKVRFYRALYSNMALFRYLTFV NNP cord-329844-w969lczb 198 2 140 140 CD cord-329844-w969lczb 198 3 . . . cord-329844-w969lczb 199 1 : : : cord-329844-w969lczb 200 1 * * NFP cord-329844-w969lczb 200 2 :* :* . cord-329844-w969lczb 201 1 : : : cord-329844-w969lczb 201 2 . . . cord-329844-w969lczb 201 3 . . . cord-329844-w969lczb 202 1 : : : cord-329844-w969lczb 202 2 : : : cord-329844-w969lczb 202 3 : : : cord-329844-w969lczb 203 1 .. .. . cord-329844-w969lczb 204 1 * * NFP cord-329844-w969lczb 204 2 . . . cord-329844-w969lczb 205 1 : : : cord-329844-w969lczb 205 2 : : : cord-329844-w969lczb 205 3 The the DT cord-329844-w969lczb 205 4 situation situation NN cord-329844-w969lczb 205 5 is be VBZ cord-329844-w969lczb 205 6 of of IN cord-329844-w969lczb 205 7 course course RB cord-329844-w969lczb 205 8 not not RB cord-329844-w969lczb 205 9 clear clear JJ cord-329844-w969lczb 205 10 when when WRB cord-329844-w969lczb 205 11 the the DT cord-329844-w969lczb 205 12 degree degree NN cord-329844-w969lczb 205 13 of of IN cord-329844-w969lczb 205 14 amino amino NN cord-329844-w969lczb 205 15 acid acid NN cord-329844-w969lczb 205 16 residue residue NN cord-329844-w969lczb 205 17 match match NN cord-329844-w969lczb 205 18 between between IN cord-329844-w969lczb 205 19 sequences sequence NNS cord-329844-w969lczb 205 20 is be VBZ cord-329844-w969lczb 205 21 poor poor JJ cord-329844-w969lczb 205 22 because because IN cord-329844-w969lczb 205 23 similarities similarity NNS cord-329844-w969lczb 205 24 can can MD cord-329844-w969lczb 205 25 arise arise VB cord-329844-w969lczb 205 26 by by IN cord-329844-w969lczb 205 27 chance chance NN cord-329844-w969lczb 205 28 , , , cord-329844-w969lczb 205 29 but but CC cord-329844-w969lczb 205 30 aligning align VBG cord-329844-w969lczb 205 31 more more JJR cord-329844-w969lczb 205 32 sequences sequence NNS cord-329844-w969lczb 205 33 can can MD cord-329844-w969lczb 205 34 be be VB cord-329844-w969lczb 205 35 insightful insightful JJ cord-329844-w969lczb 205 36 , , , cord-329844-w969lczb 205 37 and and CC cord-329844-w969lczb 205 38 in in IN cord-329844-w969lczb 205 39 this this DT cord-329844-w969lczb 205 40 case case NN cord-329844-w969lczb 205 41 including include VBG cord-329844-w969lczb 205 42 influenza influenza NN cord-329844-w969lczb 205 43 A a NN cord-329844-w969lczb 205 44 and and CC cord-329844-w969lczb 205 45 B b NN cord-329844-w969lczb 205 46 sequences sequence NNS cord-329844-w969lczb 205 47 seemed seem VBD cord-329844-w969lczb 205 48 particularly particularly RB cord-329844-w969lczb 205 49 helpful helpful JJ cord-329844-w969lczb 205 50 . . . cord-329844-w969lczb 206 1 Although although IN cord-329844-w969lczb 206 2 still still RB cord-329844-w969lczb 206 3 barely barely RB cord-329844-w969lczb 206 4 conserved conserve VBN cord-329844-w969lczb 206 5 compared compare VBN cord-329844-w969lczb 206 6 with with IN cord-329844-w969lczb 206 7 the the DT cord-329844-w969lczb 206 8 motifs motif NNS cord-329844-w969lczb 206 9 in in IN cord-329844-w969lczb 206 10 the the DT cord-329844-w969lczb 206 11 current current JJ cord-329844-w969lczb 206 12 project project NN cord-329844-w969lczb 206 13 ( ( -LRB- cord-329844-w969lczb 206 14 published publish VBN cord-329844-w969lczb 206 15 [ [ -LRB- cord-329844-w969lczb 206 16 4 4 CD cord-329844-w969lczb 206 17 , , , cord-329844-w969lczb 206 18 5 5 CD cord-329844-w969lczb 206 19 ] ] -RRB- cord-329844-w969lczb 206 20 , , , cord-329844-w969lczb 206 21 submitted submit VBN cord-329844-w969lczb 206 22 , , , cord-329844-w969lczb 206 23 or or CC cord-329844-w969lczb 206 24 under under IN cord-329844-w969lczb 206 25 investigation investigation NN cord-329844-w969lczb 206 26 ) ) -RRB- cord-329844-w969lczb 206 27 the the DT cord-329844-w969lczb 206 28 most most RBS cord-329844-w969lczb 206 29 plausible plausible JJ cord-329844-w969lczb 206 30 match match NN cord-329844-w969lczb 206 31 for for IN cord-329844-w969lczb 206 32 further further JJ cord-329844-w969lczb 206 33 study study NN cord-329844-w969lczb 206 34 is be VBZ cord-329844-w969lczb 206 35 at at IN cord-329844-w969lczb 206 36 SSSGWTAGAAAYY SSSGWTAGAAAYY NNP cord-329844-w969lczb 206 37 of of IN cord-329844-w969lczb 206 38 SARScoV2-S SARScoV2-S NNP cord-329844-w969lczb 206 39 - - HYPH cord-329844-w969lczb 206 40 MN908947.3 MN908947.3 NNP cord-329844-w969lczb 206 41 , , , cord-329844-w969lczb 206 42 because because IN cord-329844-w969lczb 206 43 others other NNS cord-329844-w969lczb 206 44 would would MD cord-329844-w969lczb 206 45 include include VB cord-329844-w969lczb 206 46 at at RB cord-329844-w969lczb 206 47 least least RBS cord-329844-w969lczb 206 48 one one CD cord-329844-w969lczb 206 49 extensive extensive JJ cord-329844-w969lczb 206 50 deletion deletion NN cord-329844-w969lczb 206 51 areas area NNS cord-329844-w969lczb 206 52 from from IN cord-329844-w969lczb 206 53 one one CD cord-329844-w969lczb 206 54 protein protein NN cord-329844-w969lczb 206 55 . . . cord-329844-w969lczb 207 1 Including include VBG cord-329844-w969lczb 207 2 influenza influenza NN cord-329844-w969lczb 207 3 A a NN cord-329844-w969lczb 207 4 and and CC cord-329844-w969lczb 207 5 B b NN cord-329844-w969lczb 207 6 sequences sequence NNS cord-329844-w969lczb 207 7 interferes interfere VBZ cord-329844-w969lczb 207 8 with with IN cord-329844-w969lczb 207 9 much much JJ cord-329844-w969lczb 207 10 of of IN cord-329844-w969lczb 207 11 the the DT cord-329844-w969lczb 207 12 alignment alignment NN cord-329844-w969lczb 207 13 but but CC cord-329844-w969lczb 207 14 it -PRON- PRP cord-329844-w969lczb 207 15 does do VBZ cord-329844-w969lczb 207 16 preserve preserve VB cord-329844-w969lczb 207 17 the the DT cord-329844-w969lczb 207 18 above above JJ cord-329844-w969lczb 207 19 match match NN cord-329844-w969lczb 207 20 . . . cord-329844-w969lczb 208 1 This this DT cord-329844-w969lczb 208 2 preserved preserve VBN cord-329844-w969lczb 208 3 match match NN cord-329844-w969lczb 208 4 region region NN cord-329844-w969lczb 208 5 also also RB cord-329844-w969lczb 208 6 places place VBZ cord-329844-w969lczb 208 7 the the DT cord-329844-w969lczb 208 8 notable notable JJ cord-329844-w969lczb 208 9 tryptophan tryptophan NN cord-329844-w969lczb 208 10 ( ( -LRB- cord-329844-w969lczb 208 11 W w NN cord-329844-w969lczb 208 12 ) ) -RRB- cord-329844-w969lczb 208 13 within within IN cord-329844-w969lczb 208 14 short short JJ cord-329844-w969lczb 208 15 distance distance NN cord-329844-w969lczb 208 16 of of IN cord-329844-w969lczb 208 17 alignment alignment NN cord-329844-w969lczb 208 18 in in IN cord-329844-w969lczb 208 19 the the DT cord-329844-w969lczb 208 20 second second JJ cord-329844-w969lczb 208 21 subsequence subsequence NN cord-329844-w969lczb 208 22 corresponding correspond VBG cord-329844-w969lczb 208 23 to to IN cord-329844-w969lczb 208 24 the the DT cord-329844-w969lczb 208 25 Zhan Zhan NNP cord-329844-w969lczb 208 26 - - HYPH cord-329844-w969lczb 208 27 Yap Yap NNP cord-329844-w969lczb 208 28 binding bind VBG cord-329844-w969lczb 208 29 site site NN cord-329844-w969lczb 208 30 , , , cord-329844-w969lczb 208 31 but but CC cord-329844-w969lczb 208 32 in in IN cord-329844-w969lczb 208 33 procedures procedure NNS cord-329844-w969lczb 208 34 of of IN cord-329844-w969lczb 208 35 this this DT cord-329844-w969lczb 208 36 kind kind NN cord-329844-w969lczb 208 37 it -PRON- PRP cord-329844-w969lczb 208 38 is be VBZ cord-329844-w969lczb 208 39 important important JJ cord-329844-w969lczb 208 40 to to TO cord-329844-w969lczb 208 41 establish establish VB cord-329844-w969lczb 208 42 that that IN cord-329844-w969lczb 208 43 such such JJ cord-329844-w969lczb 208 44 features feature NNS cord-329844-w969lczb 208 45 are be VBP cord-329844-w969lczb 208 46 not not RB cord-329844-w969lczb 208 47 simply simply RB cord-329844-w969lczb 208 48 artifacts artifact NNS cord-329844-w969lczb 208 49 of of IN cord-329844-w969lczb 208 50 the the DT cord-329844-w969lczb 208 51 particular particular JJ cord-329844-w969lczb 208 52 sequences sequence NNS cord-329844-w969lczb 208 53 included include VBD cord-329844-w969lczb 208 54 . . . cord-329844-w969lczb 209 1 The the DT cord-329844-w969lczb 209 2 essential essential JJ cord-329844-w969lczb 209 3 features feature NNS cord-329844-w969lczb 209 4 of of IN cord-329844-w969lczb 209 5 the the DT cord-329844-w969lczb 209 6 above above JJ cord-329844-w969lczb 209 7 alignments alignment NNS cord-329844-w969lczb 209 8 at at IN cord-329844-w969lczb 209 9 the the DT cord-329844-w969lczb 209 10 binding binding NN cord-329844-w969lczb 209 11 site site NN cord-329844-w969lczb 209 12 are be VBP cord-329844-w969lczb 209 13 not not RB cord-329844-w969lczb 209 14 perturbed perturb VBN cord-329844-w969lczb 209 15 by by IN cord-329844-w969lczb 209 16 removing remove VBG cord-329844-w969lczb 209 17 the the DT cord-329844-w969lczb 209 18 influenza influenza NN cord-329844-w969lczb 209 19 neuraminidases neuraminidases NNP cord-329844-w969lczb 209 20 which which WDT cord-329844-w969lczb 209 21 provided provide VBD cord-329844-w969lczb 209 22 a a DT cord-329844-w969lczb 209 23 basis basis NN cord-329844-w969lczb 209 24 for for IN cord-329844-w969lczb 209 25 the the DT cord-329844-w969lczb 209 26 Zhan Zhan NNP cord-329844-w969lczb 209 27 - - HYPH cord-329844-w969lczb 209 28 Yap Yap NNP cord-329844-w969lczb 209 29 catalytic catalytic JJ cord-329844-w969lczb 209 30 regions region NNS cord-329844-w969lczb 209 31 , , , cord-329844-w969lczb 209 32 as as IN cord-329844-w969lczb 209 33 follows follow VBZ cord-329844-w969lczb 209 34 . . . cord-329844-w969lczb 210 1 : : : cord-329844-w969lczb 210 2 : : : cord-329844-w969lczb 210 3 . . . cord-329844-w969lczb 210 4 . . . cord-329844-w969lczb 211 1 * * NFP cord-329844-w969lczb 211 2 : : : cord-329844-w969lczb 211 3 . . . cord-329844-w969lczb 212 1 : : : cord-329844-w969lczb 212 2 : : : cord-329844-w969lczb 212 3 . . . cord-329844-w969lczb 213 1 : : : cord-329844-w969lczb 214 1 * * NFP cord-329844-w969lczb 214 2 . . . cord-329844-w969lczb 215 1 ---QIIFYEGVNFNPHHRF------KCFFNGSNDVWIFNKVRFYRALYSNMALFRYLTFV ---QIIFYEGVNFNPHHRF------KCFFNGSNDVWIFNKVRFYRALYSNMALFRYLTFV NNP cord-329844-w969lczb 215 2 140 140 CD cord-329844-w969lczb 215 3 . . . cord-329844-w969lczb 216 1 : : : cord-329844-w969lczb 217 1 * * NFP cord-329844-w969lczb 217 2 :* :* . cord-329844-w969lczb 218 1 : : : cord-329844-w969lczb 218 2 . . . cord-329844-w969lczb 218 3 . . . cord-329844-w969lczb 219 1 : : : cord-329844-w969lczb 219 2 : : : cord-329844-w969lczb 219 3 : : : cord-329844-w969lczb 220 1 .. .. . cord-329844-w969lczb 221 1 * * NFP cord-329844-w969lczb 221 2 . . . cord-329844-w969lczb 222 1 : : : cord-329844-w969lczb 222 2 : : : cord-329844-w969lczb 222 3 . . . cord-329844-w969lczb 222 4 . . . cord-329844-w969lczb 223 1 # # $ cord-329844-w969lczb 223 2 # # NN cord-329844-w969lczb 223 3 # # NN cord-329844-w969lczb 223 4 # # NN cord-329844-w969lczb 223 5 Alignment Alignment NNP cord-329844-w969lczb 223 6 studies study NNS cord-329844-w969lczb 223 7 like like IN cord-329844-w969lczb 223 8 those those DT cord-329844-w969lczb 223 9 above above RB cord-329844-w969lczb 223 10 are be VBP cord-329844-w969lczb 223 11 helpful helpful JJ cord-329844-w969lczb 223 12 in in IN cord-329844-w969lczb 223 13 forming form VBG cord-329844-w969lczb 223 14 initial initial JJ cord-329844-w969lczb 223 15 hypotheses hypothesis NNS cord-329844-w969lczb 223 16 , , , cord-329844-w969lczb 223 17 but but CC cord-329844-w969lczb 223 18 they -PRON- PRP cord-329844-w969lczb 223 19 are be VBP cord-329844-w969lczb 223 20 clearly clearly RB cord-329844-w969lczb 223 21 not not RB cord-329844-w969lczb 223 22 convincing convincing JJ cord-329844-w969lczb 223 23 by by IN cord-329844-w969lczb 223 24 themselves -PRON- PRP cord-329844-w969lczb 223 25 when when WRB cord-329844-w969lczb 223 26 the the DT cord-329844-w969lczb 223 27 degrees degree NNS cord-329844-w969lczb 223 28 of of IN cord-329844-w969lczb 223 29 match match NN cord-329844-w969lczb 223 30 between between IN cord-329844-w969lczb 223 31 aligned aligned JJ cord-329844-w969lczb 223 32 residues residue NNS cord-329844-w969lczb 223 33 is be VBZ cord-329844-w969lczb 223 34 weak weak JJ cord-329844-w969lczb 223 35 ; ; : cord-329844-w969lczb 223 36 however however RB cord-329844-w969lczb 223 37 , , , cord-329844-w969lczb 223 38 it -PRON- PRP cord-329844-w969lczb 223 39 is be VBZ cord-329844-w969lczb 223 40 possible possible JJ cord-329844-w969lczb 223 41 that that IN cord-329844-w969lczb 223 42 the the DT cord-329844-w969lczb 223 43 actual actual JJ cord-329844-w969lczb 223 44 composition composition NN cord-329844-w969lczb 223 45 in in IN cord-329844-w969lczb 223 46 terms term NNS cord-329844-w969lczb 223 47 of of IN cord-329844-w969lczb 223 48 amino amino JJ cord-329844-w969lczb 223 49 acids acid NNS cord-329844-w969lczb 223 50 in in IN cord-329844-w969lczb 223 51 the the DT cord-329844-w969lczb 223 52 subsequence subsequence NN cord-329844-w969lczb 223 53 and and CC cord-329844-w969lczb 223 54 potential potential JJ cord-329844-w969lczb 223 55 motif motif NN cord-329844-w969lczb 223 56 of of IN cord-329844-w969lczb 223 57 interest interest NN cord-329844-w969lczb 223 58 is be VBZ cord-329844-w969lczb 223 59 more more RBR cord-329844-w969lczb 223 60 important important JJ cord-329844-w969lczb 223 61 than than IN cord-329844-w969lczb 223 62 their -PRON- PRP$ cord-329844-w969lczb 223 63 actual actual JJ cord-329844-w969lczb 223 64 order order NN cord-329844-w969lczb 223 65 in in IN cord-329844-w969lczb 223 66 that that DT cord-329844-w969lczb 223 67 subsequence subsequence NN cord-329844-w969lczb 223 68 . . . cord-329844-w969lczb 224 1 Based base VBN cord-329844-w969lczb 224 2 on on IN cord-329844-w969lczb 224 3 many many JJ cord-329844-w969lczb 224 4 studies study NNS cord-329844-w969lczb 224 5 exemplified exemplify VBN cord-329844-w969lczb 224 6 by by IN cord-329844-w969lczb 224 7 the the DT cord-329844-w969lczb 224 8 above above JJ cord-329844-w969lczb 224 9 , , , cord-329844-w969lczb 224 10 it -PRON- PRP cord-329844-w969lczb 224 11 was be VBD cord-329844-w969lczb 224 12 noted note VBN cord-329844-w969lczb 224 13 that that IN cord-329844-w969lczb 224 14 tryptophan tryptophan NN cord-329844-w969lczb 224 15 is be VBZ cord-329844-w969lczb 224 16 a a DT cord-329844-w969lczb 224 17 recurrent recurrent JJ cord-329844-w969lczb 224 18 , , , cord-329844-w969lczb 224 19 albeit albeit IN cord-329844-w969lczb 224 20 not not RB cord-329844-w969lczb 224 21 absolutely absolutely RB cord-329844-w969lczb 224 22 essential essential JJ cord-329844-w969lczb 224 23 , , , cord-329844-w969lczb 224 24 feature feature NN cord-329844-w969lczb 224 25 of of IN cord-329844-w969lczb 224 26 sugar sugar NN cord-329844-w969lczb 224 27 binding bind VBG cord-329844-w969lczb 224 28 including include VBG cord-329844-w969lczb 224 29 sialic sialic JJ cord-329844-w969lczb 224 30 acids acid NNS cord-329844-w969lczb 224 31 . . . cord-329844-w969lczb 225 1 References reference NNS cord-329844-w969lczb 225 2 to to IN cord-329844-w969lczb 225 3 that that DT cord-329844-w969lczb 225 4 also also RB cord-329844-w969lczb 225 5 recur recur VB cord-329844-w969lczb 225 6 throughout throughout IN cord-329844-w969lczb 225 7 the the DT cord-329844-w969lczb 225 8 biochemical biochemical JJ cord-329844-w969lczb 225 9 literature literature NN cord-329844-w969lczb 225 10 . . . cord-329844-w969lczb 226 1 For for IN cord-329844-w969lczb 226 2 example example NN cord-329844-w969lczb 226 3 , , , cord-329844-w969lczb 226 4 see see VB cord-329844-w969lczb 226 5 e.g. e.g. RB cord-329844-w969lczb 226 6 Ref Ref NNP cord-329844-w969lczb 226 7 [ [ -LRB- cord-329844-w969lczb 226 8 14 14 CD cord-329844-w969lczb 226 9 ] ] -RRB- cord-329844-w969lczb 226 10 , , , cord-329844-w969lczb 226 11 and and CC cord-329844-w969lczb 226 12 also also RB cord-329844-w969lczb 226 13 Fig Fig NNP cord-329844-w969lczb 226 14 . . . cord-329844-w969lczb 227 1 2 2 CD cord-329844-w969lczb 227 2 shows show VBZ cord-329844-w969lczb 227 3 the the DT cord-329844-w969lczb 227 4 tryptophan tryptophan NN cord-329844-w969lczb 227 5 interaction interaction NN cord-329844-w969lczb 227 6 with with IN cord-329844-w969lczb 227 7 and and CC cord-329844-w969lczb 227 8 sialic sialic JJ cord-329844-w969lczb 227 9 acid acid NN cord-329844-w969lczb 227 10 in in IN cord-329844-w969lczb 227 11 the the DT cord-329844-w969lczb 227 12 Influenza Influenza NNP cord-329844-w969lczb 227 13 Virus Virus NNP cord-329844-w969lczb 227 14 B B NNP cord-329844-w969lczb 227 15 neuraminidase neuraminidase NN cord-329844-w969lczb 227 16 ( ( -LRB- cord-329844-w969lczb 227 17 PDB PDB NNP cord-329844-w969lczb 227 18 Entry Entry NNP cord-329844-w969lczb 227 19 2BAT 2bat CD cord-329844-w969lczb 227 20 ) ) -RRB- cord-329844-w969lczb 227 21 . . . cord-329844-w969lczb 228 1 As as IN cord-329844-w969lczb 228 2 might may MD cord-329844-w969lczb 228 3 be be VB cord-329844-w969lczb 228 4 expected expect VBN cord-329844-w969lczb 228 5 by by IN cord-329844-w969lczb 228 6 their -PRON- PRP$ cord-329844-w969lczb 228 7 similar similar JJ cord-329844-w969lczb 228 8 aromatic aromatic JJ cord-329844-w969lczb 228 9 character character NN cord-329844-w969lczb 228 10 , , , cord-329844-w969lczb 228 11 the the DT cord-329844-w969lczb 228 12 alternative alternative JJ cord-329844-w969lczb 228 13 amino amino NN cord-329844-w969lczb 228 14 acid acid NN cord-329844-w969lczb 228 15 residues residue NNS cord-329844-w969lczb 228 16 as as IN cord-329844-w969lczb 228 17 sugar sugar NN cord-329844-w969lczb 228 18 binders binder NNS cord-329844-w969lczb 228 19 , , , cord-329844-w969lczb 228 20 and and CC cord-329844-w969lczb 228 21 residues residue NNS cord-329844-w969lczb 228 22 frequently frequently RB cord-329844-w969lczb 228 23 supporting support VBG cord-329844-w969lczb 228 24 tryptophan tryptophan NN cord-329844-w969lczb 228 25 in in IN cord-329844-w969lczb 228 26 the the DT cord-329844-w969lczb 228 27 binding binding NN cord-329844-w969lczb 228 28 site site NN cord-329844-w969lczb 228 29 , , , cord-329844-w969lczb 228 30 tend tend VBP cord-329844-w969lczb 228 31 to to TO cord-329844-w969lczb 228 32 be be VB cord-329844-w969lczb 228 33 aromatic aromatic JJ cord-329844-w969lczb 228 34 sidechains sidechain NNS cord-329844-w969lczb 228 35 , , , cord-329844-w969lczb 228 36 notably notably RB cord-329844-w969lczb 228 37 tyrosine tyrosine NN cord-329844-w969lczb 228 38 ( ( -LRB- cord-329844-w969lczb 228 39 Y Y NNP cord-329844-w969lczb 228 40 ) ) -RRB- cord-329844-w969lczb 228 41 , , , cord-329844-w969lczb 228 42 sometimes sometimes RB cord-329844-w969lczb 228 43 phenylalanine phenylalanine NN cord-329844-w969lczb 228 44 ( ( -LRB- cord-329844-w969lczb 228 45 F F NNP cord-329844-w969lczb 228 46 ) ) -RRB- cord-329844-w969lczb 228 47 and and CC cord-329844-w969lczb 228 48 histidine histidine NN cord-329844-w969lczb 228 49 ( ( -LRB- cord-329844-w969lczb 228 50 H H NNP cord-329844-w969lczb 228 51 ) ) -RRB- cord-329844-w969lczb 228 52 . . . cord-329844-w969lczb 229 1 A a DT cord-329844-w969lczb 229 2 preliminary preliminary JJ cord-329844-w969lczb 229 3 survey survey NN cord-329844-w969lczb 229 4 of of IN cord-329844-w969lczb 229 5 sequence sequence NN cord-329844-w969lczb 229 6 motif motif NN cord-329844-w969lczb 229 7 patterns pattern NNS cord-329844-w969lczb 229 8 in in IN cord-329844-w969lczb 229 9 sugar sugar NN cord-329844-w969lczb 229 10 binding binding NN cord-329844-w969lczb 229 11 proteins protein NNS cord-329844-w969lczb 229 12 suggests suggest VBZ cord-329844-w969lczb 229 13 that that IN cord-329844-w969lczb 229 14 invariant invariant JJ cord-329844-w969lczb 229 15 amino amino NN cord-329844-w969lczb 229 16 acid acid NN cord-329844-w969lczb 229 17 residues residue NNS cord-329844-w969lczb 229 18 across across IN cord-329844-w969lczb 229 19 a a DT cord-329844-w969lczb 229 20 family family NN cord-329844-w969lczb 229 21 of of IN cord-329844-w969lczb 229 22 proteins protein NNS cord-329844-w969lczb 229 23 tend tend VBP cord-329844-w969lczb 229 24 be be VB cord-329844-w969lczb 229 25 one one CD cord-329844-w969lczb 229 26 or or CC cord-329844-w969lczb 229 27 more more JJR cord-329844-w969lczb 229 28 of of IN cord-329844-w969lczb 229 29 the the DT cord-329844-w969lczb 229 30 above above JJ cord-329844-w969lczb 229 31 aromatic aromatic JJ cord-329844-w969lczb 229 32 residues residue NNS cord-329844-w969lczb 229 33 supported support VBN cord-329844-w969lczb 229 34 by by IN cord-329844-w969lczb 229 35 negatively negatively RB cord-329844-w969lczb 229 36 charged charge VBN cord-329844-w969lczb 229 37 aspartate aspartate NN cord-329844-w969lczb 229 38 ( ( -LRB- cord-329844-w969lczb 229 39 D D NNP cord-329844-w969lczb 229 40 ) ) -RRB- cord-329844-w969lczb 229 41 , , , cord-329844-w969lczb 229 42 asparagine asparagine NN cord-329844-w969lczb 229 43 ( ( -LRB- cord-329844-w969lczb 229 44 N N NNP cord-329844-w969lczb 229 45 ) ) -RRB- cord-329844-w969lczb 229 46 , , , cord-329844-w969lczb 229 47 serine serine NN cord-329844-w969lczb 229 48 ( ( -LRB- cord-329844-w969lczb 229 49 S S NNP cord-329844-w969lczb 229 50 ) ) -RRB- cord-329844-w969lczb 229 51 , , , cord-329844-w969lczb 229 52 threonine threonine NN cord-329844-w969lczb 229 53 ( ( -LRB- cord-329844-w969lczb 229 54 T t NN cord-329844-w969lczb 229 55 ) ) -RRB- cord-329844-w969lczb 229 56 glycine glycine NN cord-329844-w969lczb 229 57 ( ( -LRB- cord-329844-w969lczb 229 58 G g NN cord-329844-w969lczb 229 59 ) ) -RRB- cord-329844-w969lczb 229 60 and and CC cord-329844-w969lczb 229 61 sometimes sometimes RB cord-329844-w969lczb 229 62 alanine alanine NNP cord-329844-w969lczb 229 63 ( ( -LRB- cord-329844-w969lczb 229 64 A a NN cord-329844-w969lczb 229 65 ) ) -RRB- cord-329844-w969lczb 229 66 that that WDT cord-329844-w969lczb 229 67 provide provide VBP cord-329844-w969lczb 229 68 the the DT cord-329844-w969lczb 229 69 hydrogen hydrogen NN cord-329844-w969lczb 229 70 bonding bonding NN cord-329844-w969lczb 229 71 . . . cord-329844-w969lczb 230 1 However however RB cord-329844-w969lczb 230 2 , , , cord-329844-w969lczb 230 3 particularly particularly RB cord-329844-w969lczb 230 4 in in IN cord-329844-w969lczb 230 5 regard regard NN cord-329844-w969lczb 230 6 to to IN cord-329844-w969lczb 230 7 the the DT cord-329844-w969lczb 230 8 non non JJ cord-329844-w969lczb 230 9 - - JJ cord-329844-w969lczb 230 10 aromatic aromatic JJ cord-329844-w969lczb 230 11 residues residue NNS cord-329844-w969lczb 230 12 , , , cord-329844-w969lczb 230 13 the the DT cord-329844-w969lczb 230 14 binding binding NN cord-329844-w969lczb 230 15 of of IN cord-329844-w969lczb 230 16 acidic acidic JJ cord-329844-w969lczb 230 17 and and CC cord-329844-w969lczb 230 18 non non JJ cord-329844-w969lczb 230 19 - - JJ cord-329844-w969lczb 230 20 acidic acidic JJ cord-329844-w969lczb 230 21 sugars sugar NNS cord-329844-w969lczb 230 22 should should MD cord-329844-w969lczb 230 23 probably probably RB cord-329844-w969lczb 230 24 be be VB cord-329844-w969lczb 230 25 distinguished distinguish VBN cord-329844-w969lczb 230 26 . . . cord-329844-w969lczb 231 1 As as IN cord-329844-w969lczb 231 2 discussed discuss VBN cord-329844-w969lczb 231 3 later later RB cord-329844-w969lczb 231 4 below below RB cord-329844-w969lczb 231 5 , , , cord-329844-w969lczb 231 6 charged charge VBN cord-329844-w969lczb 231 7 amino amino NN cord-329844-w969lczb 231 8 acid acid NN cord-329844-w969lczb 231 9 residues residue NNS cord-329844-w969lczb 231 10 glutamate glutamate NN cord-329844-w969lczb 231 11 ( ( -LRB- cord-329844-w969lczb 231 12 E E NNP cord-329844-w969lczb 231 13 ) ) -RRB- cord-329844-w969lczb 231 14 , , , cord-329844-w969lczb 231 15 arginine arginine NN cord-329844-w969lczb 231 16 ( ( -LRB- cord-329844-w969lczb 231 17 R r NN cord-329844-w969lczb 231 18 ) ) -RRB- cord-329844-w969lczb 231 19 , , , cord-329844-w969lczb 231 20 and and CC cord-329844-w969lczb 231 21 lysine lysine NN cord-329844-w969lczb 231 22 ( ( -LRB- cord-329844-w969lczb 231 23 K K NNP cord-329844-w969lczb 231 24 ) ) -RRB- cord-329844-w969lczb 231 25 also also RB cord-329844-w969lczb 231 26 frequently frequently RB cord-329844-w969lczb 231 27 make make VBP cord-329844-w969lczb 231 28 intimate intimate JJ cord-329844-w969lczb 231 29 contact contact NN cord-329844-w969lczb 231 30 with with IN cord-329844-w969lczb 231 31 sialic sialic JJ cord-329844-w969lczb 231 32 acids acid NNS cord-329844-w969lczb 231 33 but but CC cord-329844-w969lczb 231 34 that that DT cord-329844-w969lczb 231 35 is be VBZ cord-329844-w969lczb 231 36 in in IN cord-329844-w969lczb 231 37 three three CD cord-329844-w969lczb 231 38 dimensions dimension NNS cord-329844-w969lczb 231 39 , , , cord-329844-w969lczb 231 40 not not RB cord-329844-w969lczb 231 41 together together RB cord-329844-w969lczb 231 42 in in IN cord-329844-w969lczb 231 43 a a DT cord-329844-w969lczb 231 44 subsequence subsequence NN cord-329844-w969lczb 231 45 . . . cord-329844-w969lczb 232 1 A a DT cord-329844-w969lczb 232 2 likely likely RB cord-329844-w969lczb 232 3 relevant relevant JJ cord-329844-w969lczb 232 4 observation observation NN cord-329844-w969lczb 232 5 was be VBD cord-329844-w969lczb 232 6 that that IN cord-329844-w969lczb 232 7 the the DT cord-329844-w969lczb 232 8 first first JJ cord-329844-w969lczb 232 9 set set NN cord-329844-w969lczb 232 10 of of IN cord-329844-w969lczb 232 11 amino amino NN cord-329844-w969lczb 232 12 acid acid NN cord-329844-w969lczb 232 13 residues residue NNS cord-329844-w969lczb 232 14 ( ( -LRB- cord-329844-w969lczb 232 15 the the DT cord-329844-w969lczb 232 16 set set NN cord-329844-w969lczb 232 17 containing contain VBG cord-329844-w969lczb 232 18 aspartate aspartate NN cord-329844-w969lczb 232 19 ) ) -RRB- cord-329844-w969lczb 232 20 and and CC cord-329844-w969lczb 232 21 binding bind VBG cord-329844-w969lczb 232 22 sialic sialic JJ cord-329844-w969lczb 232 23 acids acid NNS cord-329844-w969lczb 232 24 tended tend VBD cord-329844-w969lczb 232 25 to to TO cord-329844-w969lczb 232 26 occur occur VB cord-329844-w969lczb 232 27 in in IN cord-329844-w969lczb 232 28 a a DT cord-329844-w969lczb 232 29 subsequence subsequence NN cord-329844-w969lczb 232 30 that that WDT cord-329844-w969lczb 232 31 adopted adopt VBD cord-329844-w969lczb 232 32 a a DT cord-329844-w969lczb 232 33 local local JJ cord-329844-w969lczb 232 34 loop loop NN cord-329844-w969lczb 232 35 conformation conformation NN cord-329844-w969lczb 232 36 , , , cord-329844-w969lczb 232 37 while while IN cord-329844-w969lczb 232 38 the the DT cord-329844-w969lczb 232 39 second second JJ cord-329844-w969lczb 232 40 set set NN cord-329844-w969lczb 232 41 ( ( -LRB- cord-329844-w969lczb 232 42 that that IN cord-329844-w969lczb 232 43 containing contain VBG cord-329844-w969lczb 232 44 glutamate glutamate NN cord-329844-w969lczb 232 45 ) ) -RRB- cord-329844-w969lczb 232 46 were be VBD cord-329844-w969lczb 232 47 frequently frequently RB cord-329844-w969lczb 232 48 associated associate VBN cord-329844-w969lczb 232 49 with with IN cord-329844-w969lczb 232 50 α α NN cord-329844-w969lczb 232 51 - - HYPH cord-329844-w969lczb 232 52 helices helix NNS cord-329844-w969lczb 232 53 and and CC cord-329844-w969lczb 232 54 particularly particularly RB cord-329844-w969lczb 232 55 their -PRON- PRP$ cord-329844-w969lczb 232 56 termini terminus NNS cord-329844-w969lczb 232 57 . . . cord-329844-w969lczb 233 1 However however RB cord-329844-w969lczb 233 2 , , , cord-329844-w969lczb 233 3 this this DT cord-329844-w969lczb 233 4 was be VBD cord-329844-w969lczb 233 5 an an DT cord-329844-w969lczb 233 6 empirical empirical JJ cord-329844-w969lczb 233 7 and and CC cord-329844-w969lczb 233 8 qualitative qualitative JJ cord-329844-w969lczb 233 9 observation observation NN cord-329844-w969lczb 233 10 regarding regard VBG cord-329844-w969lczb 233 11 a a DT cord-329844-w969lczb 233 12 tendency tendency NN cord-329844-w969lczb 233 13 , , , cord-329844-w969lczb 233 14 and and CC cord-329844-w969lczb 233 15 a a DT cord-329844-w969lczb 233 16 more more RBR cord-329844-w969lczb 233 17 objective objective JJ cord-329844-w969lczb 233 18 quantification quantification NN cord-329844-w969lczb 233 19 of of IN cord-329844-w969lczb 233 20 the the DT cord-329844-w969lczb 233 21 importance importance NN cord-329844-w969lczb 233 22 of of IN cord-329844-w969lczb 233 23 the the DT cord-329844-w969lczb 233 24 aspartate aspartate NN cord-329844-w969lczb 233 25 set set NN cord-329844-w969lczb 233 26 is be VBZ cord-329844-w969lczb 233 27 the the DT cord-329844-w969lczb 233 28 purpose purpose NN cord-329844-w969lczb 233 29 of of IN cord-329844-w969lczb 233 30 the the DT cord-329844-w969lczb 233 31 prediction prediction NN cord-329844-w969lczb 233 32 algorithm algorithm NN cord-329844-w969lczb 233 33 developed develop VBN cord-329844-w969lczb 233 34 below below RB cord-329844-w969lczb 233 35 . . . cord-329844-w969lczb 234 1 Three three CD cord-329844-w969lczb 234 2 dimensional dimensional JJ cord-329844-w969lczb 234 3 considerations consideration NNS cord-329844-w969lczb 234 4 , , , cord-329844-w969lczb 234 5 however however RB cord-329844-w969lczb 234 6 , , , cord-329844-w969lczb 234 7 give give VB cord-329844-w969lczb 234 8 insight insight NN cord-329844-w969lczb 234 9 and and CC cord-329844-w969lczb 234 10 sometimes sometimes RB cord-329844-w969lczb 234 11 explain explain VB cord-329844-w969lczb 234 12 why why WRB cord-329844-w969lczb 234 13 influences influence NNS cord-329844-w969lczb 234 14 can can MD cord-329844-w969lczb 234 15 be be VB cord-329844-w969lczb 234 16 somewhat somewhat RB cord-329844-w969lczb 234 17 indirect indirect JJ cord-329844-w969lczb 234 18 . . . cord-329844-w969lczb 235 1 Hydrogen hydrogen NN cord-329844-w969lczb 235 2 bonding bonding NN cord-329844-w969lczb 235 3 that that WDT cord-329844-w969lczb 235 4 occurs occur VBZ cord-329844-w969lczb 235 5 between between IN cord-329844-w969lczb 235 6 the the DT cord-329844-w969lczb 235 7 hydroxyl hydroxyl NN cord-329844-w969lczb 235 8 groups group NNS cord-329844-w969lczb 235 9 of of IN cord-329844-w969lczb 235 10 carbohydrate carbohydrate NN cord-329844-w969lczb 235 11 ligands ligand NNS cord-329844-w969lczb 235 12 and and CC cord-329844-w969lczb 235 13 polar polar JJ cord-329844-w969lczb 235 14 amino amino NN cord-329844-w969lczb 235 15 acid acid NN cord-329844-w969lczb 235 16 residues residue NNS cord-329844-w969lczb 235 17 at at IN cord-329844-w969lczb 235 18 the the DT cord-329844-w969lczb 235 19 binding binding NN cord-329844-w969lczb 235 20 site site NN cord-329844-w969lczb 235 21 is be VBZ cord-329844-w969lczb 235 22 typically typically RB cord-329844-w969lczb 235 23 supported support VBN cord-329844-w969lczb 235 24 by by IN cord-329844-w969lczb 235 25 water water NN cord-329844-w969lczb 235 26 - - HYPH cord-329844-w969lczb 235 27 mediated mediate VBN cord-329844-w969lczb 235 28 hydrogen hydrogen NN cord-329844-w969lczb 235 29 bonding bonding NN cord-329844-w969lczb 235 30 networks network NNS cord-329844-w969lczb 235 31 in in IN cord-329844-w969lczb 235 32 which which WDT cord-329844-w969lczb 235 33 serine serine NN cord-329844-w969lczb 235 34 and and CC cord-329844-w969lczb 235 35 threonine threonine NN cord-329844-w969lczb 235 36 are be VBP cord-329844-w969lczb 235 37 fairly fairly RB cord-329844-w969lczb 235 38 commonly commonly RB cord-329844-w969lczb 235 39 involved involve VBN cord-329844-w969lczb 235 40 . . . cord-329844-w969lczb 236 1 Nonetheless nonetheless RB cord-329844-w969lczb 236 2 , , , cord-329844-w969lczb 236 3 the the DT cord-329844-w969lczb 236 4 most most RBS cord-329844-w969lczb 236 5 outstanding outstanding JJ cord-329844-w969lczb 236 6 feature feature NN cord-329844-w969lczb 236 7 of of IN cord-329844-w969lczb 236 8 carbohydrate carbohydrate NN cord-329844-w969lczb 236 9 binding binding NN cord-329844-w969lczb 236 10 sites site NNS cord-329844-w969lczb 236 11 from from IN cord-329844-w969lczb 236 12 a a DT cord-329844-w969lczb 236 13 three three CD cord-329844-w969lczb 236 14 dimensional dimensional JJ cord-329844-w969lczb 236 15 perspective perspective NN cord-329844-w969lczb 236 16 would would MD cord-329844-w969lczb 236 17 appear appear VB cord-329844-w969lczb 236 18 to to TO cord-329844-w969lczb 236 19 be be VB cord-329844-w969lczb 236 20 the the DT cord-329844-w969lczb 236 21 position position NN cord-329844-w969lczb 236 22 and and CC cord-329844-w969lczb 236 23 orientation orientation NN cord-329844-w969lczb 236 24 of of IN cord-329844-w969lczb 236 25 tryptophan tryptophan NN cord-329844-w969lczb 236 26 ( ( -LRB- cord-329844-w969lczb 236 27 W W NNP cord-329844-w969lczb 236 28 ) ) -RRB- cord-329844-w969lczb 236 29 , , , cord-329844-w969lczb 236 30 tyrosine tyrosine NN cord-329844-w969lczb 236 31 ( ( -LRB- cord-329844-w969lczb 236 32 Y Y NNP cord-329844-w969lczb 236 33 ) ) -RRB- cord-329844-w969lczb 236 34 , , , cord-329844-w969lczb 236 35 and/or and/or CC cord-329844-w969lczb 236 36 phenylalanine phenylalanine NN cord-329844-w969lczb 236 37 ( ( -LRB- cord-329844-w969lczb 236 38 F F NNP cord-329844-w969lczb 236 39 ) ) -RRB- cord-329844-w969lczb 236 40 , , , cord-329844-w969lczb 236 41 which which WDT cord-329844-w969lczb 236 42 usually usually RB cord-329844-w969lczb 236 43 provide provide VBP cord-329844-w969lczb 236 44 a a DT cord-329844-w969lczb 236 45 hydrophobic hydrophobic JJ cord-329844-w969lczb 236 46 plate plate NN cord-329844-w969lczb 236 47 for for IN cord-329844-w969lczb 236 48 close close JJ cord-329844-w969lczb 236 49 interaction interaction NN cord-329844-w969lczb 236 50 with with IN cord-329844-w969lczb 236 51 the the DT cord-329844-w969lczb 236 52 planar planar JJ cord-329844-w969lczb 236 53 face face NN cord-329844-w969lczb 236 54 of of IN cord-329844-w969lczb 236 55 sugar sugar NN cord-329844-w969lczb 236 56 rings ring NNS cord-329844-w969lczb 236 57 , , , cord-329844-w969lczb 236 58 an an DT cord-329844-w969lczb 236 59 interaction interaction NN cord-329844-w969lczb 236 60 resembling resemble VBG cord-329844-w969lczb 236 61 hydrophobic hydrophobic JJ cord-329844-w969lczb 236 62 stacking stacking NN cord-329844-w969lczb 236 63 interactions interaction NNS cord-329844-w969lczb 236 64 , , , cord-329844-w969lczb 236 65 as as IN cord-329844-w969lczb 236 66 in in IN cord-329844-w969lczb 236 67 Fig Fig NNP cord-329844-w969lczb 236 68 . . . cord-329844-w969lczb 237 1 2 2 LS cord-329844-w969lczb 237 2 . . . cord-329844-w969lczb 238 1 The the DT cord-329844-w969lczb 238 2 importance importance NN cord-329844-w969lczb 238 3 of of IN cord-329844-w969lczb 238 4 these these DT cord-329844-w969lczb 238 5 and and CC cord-329844-w969lczb 238 6 to to IN cord-329844-w969lczb 238 7 some some DT cord-329844-w969lczb 238 8 extent extent NN cord-329844-w969lczb 238 9 of of IN cord-329844-w969lczb 238 10 histidine histidine NN cord-329844-w969lczb 238 11 ( ( -LRB- cord-329844-w969lczb 238 12 H H NNP cord-329844-w969lczb 238 13 ) ) -RRB- cord-329844-w969lczb 238 14 in in IN cord-329844-w969lczb 238 15 a a DT cord-329844-w969lczb 238 16 sequence sequence NN cord-329844-w969lczb 238 17 motif motif NN cord-329844-w969lczb 238 18 seems seem VBZ cord-329844-w969lczb 238 19 reasonable reasonable JJ cord-329844-w969lczb 238 20 . . . cord-329844-w969lczb 239 1 Along along IN cord-329844-w969lczb 239 2 with with IN cord-329844-w969lczb 239 3 the the DT cord-329844-w969lczb 239 4 occasional occasional JJ cord-329844-w969lczb 239 5 appearance appearance NN cord-329844-w969lczb 239 6 of of IN cord-329844-w969lczb 239 7 cysteine cysteine NN cord-329844-w969lczb 239 8 ( ( -LRB- cord-329844-w969lczb 239 9 C C NNP cord-329844-w969lczb 239 10 ) ) -RRB- cord-329844-w969lczb 239 11 , , , cord-329844-w969lczb 239 12 sometimes sometimes RB cord-329844-w969lczb 239 13 as as IN cord-329844-w969lczb 239 14 a a DT cord-329844-w969lczb 239 15 serine serine NN cord-329844-w969lczb 239 16 ( ( -LRB- cord-329844-w969lczb 239 17 S s NN cord-329844-w969lczb 239 18 ) ) -RRB- cord-329844-w969lczb 239 19 and and CC cord-329844-w969lczb 239 20 particularly particularly RB cord-329844-w969lczb 239 21 a a DT cord-329844-w969lczb 239 22 threonine threonine NN cord-329844-w969lczb 239 23 ( ( -LRB- cord-329844-w969lczb 239 24 T t NN cord-329844-w969lczb 239 25 ) ) -RRB- cord-329844-w969lczb 239 26 substitution substitution NN cord-329844-w969lczb 239 27 , , , cord-329844-w969lczb 239 28 the the DT cord-329844-w969lczb 239 29 residues residue NNS cord-329844-w969lczb 239 30 mentioned mention VBN cord-329844-w969lczb 239 31 above above RB cord-329844-w969lczb 239 32 can can MD cord-329844-w969lczb 239 33 be be VB cord-329844-w969lczb 239 34 used use VBN cord-329844-w969lczb 239 35 as as IN cord-329844-w969lczb 239 36 the the DT cord-329844-w969lczb 239 37 basis basis NN cord-329844-w969lczb 239 38 of of IN cord-329844-w969lczb 239 39 a a DT cord-329844-w969lczb 239 40 preliminary preliminary JJ cord-329844-w969lczb 239 41 and and CC cord-329844-w969lczb 239 42 essentially essentially RB cord-329844-w969lczb 239 43 qualitative qualitative JJ cord-329844-w969lczb 239 44 model model NN cord-329844-w969lczb 239 45 for for IN cord-329844-w969lczb 239 46 assessment assessment NN cord-329844-w969lczb 239 47 of of IN cord-329844-w969lczb 239 48 sugar sugar NN cord-329844-w969lczb 239 49 binding bind VBG cord-329844-w969lczb 239 50 as as IN cord-329844-w969lczb 239 51 given give VBN cord-329844-w969lczb 239 52 column column NN cord-329844-w969lczb 239 53 4 4 CD cord-329844-w969lczb 239 54 of of IN cord-329844-w969lczb 239 55 Table Table NNP cord-329844-w969lczb 239 56 1 1 CD cord-329844-w969lczb 239 57 . . . cord-329844-w969lczb 240 1 Often often RB cord-329844-w969lczb 240 2 a a DT cord-329844-w969lczb 240 3 valine valine NN cord-329844-w969lczb 240 4 ( ( -LRB- cord-329844-w969lczb 240 5 V v NN cord-329844-w969lczb 240 6 ) ) -RRB- cord-329844-w969lczb 240 7 substitution substitution NN cord-329844-w969lczb 240 8 was be VBD cord-329844-w969lczb 240 9 seen see VBN cord-329844-w969lczb 240 10 in in IN cord-329844-w969lczb 240 11 potential potential JJ cord-329844-w969lczb 240 12 glycan glycan NN cord-329844-w969lczb 240 13 binding bind VBG cord-329844-w969lczb 240 14 sites site NNS cord-329844-w969lczb 240 15 , , , cord-329844-w969lczb 240 16 although although IN cord-329844-w969lczb 240 17 this this DT cord-329844-w969lczb 240 18 was be VBD cord-329844-w969lczb 240 19 not not RB cord-329844-w969lczb 240 20 significantly significantly RB cord-329844-w969lczb 240 21 supported support VBN cord-329844-w969lczb 240 22 by by IN cord-329844-w969lczb 240 23 the the DT cord-329844-w969lczb 240 24 optimization optimization NN cord-329844-w969lczb 240 25 of of IN cord-329844-w969lczb 240 26 the the DT cord-329844-w969lczb 240 27 predictive predictive JJ cord-329844-w969lczb 240 28 technique technique NN cord-329844-w969lczb 240 29 described describe VBN cord-329844-w969lczb 240 30 below below RB cord-329844-w969lczb 240 31 . . . cord-329844-w969lczb 241 1 However however RB cord-329844-w969lczb 241 2 , , , cord-329844-w969lczb 241 3 glycans glycan NNS cord-329844-w969lczb 241 4 containing contain VBG cord-329844-w969lczb 241 5 sialic sialic JJ cord-329844-w969lczb 241 6 acids acid NNS cord-329844-w969lczb 241 7 appear appear VBP cord-329844-w969lczb 241 8 to to TO cord-329844-w969lczb 241 9 bind bind VB cord-329844-w969lczb 241 10 somewhat somewhat RB cord-329844-w969lczb 241 11 differently differently RB cord-329844-w969lczb 241 12 to to IN cord-329844-w969lczb 241 13 other other JJ cord-329844-w969lczb 241 14 sugars sugar NNS cord-329844-w969lczb 241 15 . . . cord-329844-w969lczb 242 1 Taking take VBG cord-329844-w969lczb 242 2 this this DT cord-329844-w969lczb 242 3 as as IN cord-329844-w969lczb 242 4 a a DT cord-329844-w969lczb 242 5 hypothesis hypothesis NN cord-329844-w969lczb 242 6 and and CC cord-329844-w969lczb 242 7 focusing focus VBG cord-329844-w969lczb 242 8 on on IN cord-329844-w969lczb 242 9 these these DT cord-329844-w969lczb 242 10 , , , cord-329844-w969lczb 242 11 protein protein NN cord-329844-w969lczb 242 12 sites site NNS cord-329844-w969lczb 242 13 for for IN cord-329844-w969lczb 242 14 binding bind VBG cord-329844-w969lczb 242 15 them -PRON- PRP cord-329844-w969lczb 242 16 may may MD cord-329844-w969lczb 242 17 have have VB cord-329844-w969lczb 242 18 a a DT cord-329844-w969lczb 242 19 variety variety NN cord-329844-w969lczb 242 20 of of IN cord-329844-w969lczb 242 21 affinities affinity NNS cord-329844-w969lczb 242 22 for for IN cord-329844-w969lczb 242 23 different different JJ cord-329844-w969lczb 242 24 subtypes subtype NNS cord-329844-w969lczb 242 25 . . . cord-329844-w969lczb 243 1 For for IN cord-329844-w969lczb 243 2 example example NN cord-329844-w969lczb 243 3 , , , cord-329844-w969lczb 243 4 all all DT cord-329844-w969lczb 243 5 influenza influenza NN cord-329844-w969lczb 243 6 A a DT cord-329844-w969lczb 243 7 virus virus NN cord-329844-w969lczb 243 8 strains strain NNS cord-329844-w969lczb 243 9 critically critically RB cord-329844-w969lczb 243 10 depend depend VBP cord-329844-w969lczb 243 11 on on IN cord-329844-w969lczb 243 12 sialic sialic JJ cord-329844-w969lczb 243 13 acid acid NN cord-329844-w969lczb 243 14 to to TO cord-329844-w969lczb 243 15 bind bind VB cord-329844-w969lczb 243 16 to to IN cord-329844-w969lczb 243 17 host host NN cord-329844-w969lczb 243 18 cells cell NNS cord-329844-w969lczb 243 19 and and CC cord-329844-w969lczb 243 20 the the DT cord-329844-w969lczb 243 21 different different JJ cord-329844-w969lczb 243 22 forms form NNS cord-329844-w969lczb 243 23 of of IN cord-329844-w969lczb 243 24 sialic sialic JJ cord-329844-w969lczb 243 25 acids acid NNS cord-329844-w969lczb 243 26 all all DT cord-329844-w969lczb 243 27 show show VBP cord-329844-w969lczb 243 28 different different JJ cord-329844-w969lczb 243 29 affinities affinity NNS cord-329844-w969lczb 243 30 that that WDT cord-329844-w969lczb 243 31 change change VBP cord-329844-w969lczb 243 32 with with IN cord-329844-w969lczb 243 33 influenza influenza NN cord-329844-w969lczb 243 34 A a DT cord-329844-w969lczb 243 35 virus virus NN cord-329844-w969lczb 243 36 variety variety NN cord-329844-w969lczb 243 37 , , , cord-329844-w969lczb 243 38 important important JJ cord-329844-w969lczb 243 39 because because IN cord-329844-w969lczb 243 40 it -PRON- PRP cord-329844-w969lczb 243 41 determines determine VBZ cord-329844-w969lczb 243 42 which which WDT cord-329844-w969lczb 243 43 species specie NNS cord-329844-w969lczb 243 44 can can MD cord-329844-w969lczb 243 45 be be VB cord-329844-w969lczb 243 46 infected infect VBN cord-329844-w969lczb 243 47 . . . cord-329844-w969lczb 244 1 There there EX cord-329844-w969lczb 244 2 has have VBZ cord-329844-w969lczb 244 3 also also RB cord-329844-w969lczb 244 4 been be VBN cord-329844-w969lczb 244 5 very very RB cord-329844-w969lczb 244 6 relevant relevant JJ cord-329844-w969lczb 244 7 work work NN cord-329844-w969lczb 244 8 that that WDT cord-329844-w969lczb 244 9 can can MD cord-329844-w969lczb 244 10 complicate complicate VB cord-329844-w969lczb 244 11 the the DT cord-329844-w969lczb 244 12 details detail NNS cord-329844-w969lczb 244 13 of of IN cord-329844-w969lczb 244 14 what what WP cord-329844-w969lczb 244 15 can can MD cord-329844-w969lczb 244 16 be be VB cord-329844-w969lczb 244 17 meant mean VBN cord-329844-w969lczb 244 18 by by IN cord-329844-w969lczb 244 19 , , , cord-329844-w969lczb 244 20 for for IN cord-329844-w969lczb 244 21 example example NN cord-329844-w969lczb 244 22 , , , cord-329844-w969lczb 244 23 " " `` cord-329844-w969lczb 244 24 sugar sugar NN cord-329844-w969lczb 244 25 binding binding NN cord-329844-w969lczb 244 26 motif motif NN cord-329844-w969lczb 244 27 " " '' cord-329844-w969lczb 244 28 . . . cord-329844-w969lczb 245 1 Indeed indeed RB cord-329844-w969lczb 245 2 , , , cord-329844-w969lczb 245 3 Zhang Zhang NNP cord-329844-w969lczb 245 4 and and CC cord-329844-w969lczb 245 5 Yap Yap NNP cord-329844-w969lczb 245 6 [ [ -LRB- cord-329844-w969lczb 245 7 13 13 CD cord-329844-w969lczb 245 8 ] ] -RRB- cord-329844-w969lczb 245 9 themselves -PRON- PRP cord-329844-w969lczb 245 10 noted note VBD cord-329844-w969lczb 245 11 that that IN cord-329844-w969lczb 245 12 tryptophan tryptophan NN cord-329844-w969lczb 245 13 was be VBD cord-329844-w969lczb 245 14 frequently frequently RB cord-329844-w969lczb 245 15 involved involve VBN cord-329844-w969lczb 245 16 in in IN cord-329844-w969lczb 245 17 strong strong JJ cord-329844-w969lczb 245 18 protein protein NN cord-329844-w969lczb 245 19 fold fold VBP cord-329844-w969lczb 245 20 interactions interaction NNS cord-329844-w969lczb 245 21 that that WDT cord-329844-w969lczb 245 22 stabilized stabilize VBD cord-329844-w969lczb 245 23 the the DT cord-329844-w969lczb 245 24 sugar sugar NN cord-329844-w969lczb 245 25 binding bind VBG cord-329844-w969lczb 245 26 domain domain NN cord-329844-w969lczb 245 27 fold fold NN cord-329844-w969lczb 245 28 , , , cord-329844-w969lczb 245 29 yet yet CC cord-329844-w969lczb 245 30 lacked lack VBD cord-329844-w969lczb 245 31 any any DT cord-329844-w969lczb 245 32 direct direct JJ cord-329844-w969lczb 245 33 interactions interaction NNS cord-329844-w969lczb 245 34 with with IN cord-329844-w969lczb 245 35 sugars sugar NNS cord-329844-w969lczb 245 36 . . . cord-329844-w969lczb 246 1 In in IN cord-329844-w969lczb 246 2 the the DT cord-329844-w969lczb 246 3 influenza influenza NN cord-329844-w969lczb 246 4 neuraminidase neuraminidase NN cord-329844-w969lczb 246 5 they -PRON- PRP cord-329844-w969lczb 246 6 comprised comprise VBD cord-329844-w969lczb 246 7 three three CD cord-329844-w969lczb 246 8 pairs pair NNS cord-329844-w969lczb 246 9 of of IN cord-329844-w969lczb 246 10 main main JJ cord-329844-w969lczb 246 11 chain chain NN cord-329844-w969lczb 246 12 - - HYPH cord-329844-w969lczb 246 13 side side NN cord-329844-w969lczb 246 14 chain chain NN cord-329844-w969lczb 246 15 interactions interaction NNS cord-329844-w969lczb 246 16 : : : cord-329844-w969lczb 246 17 tryptophan tryptophan NN cord-329844-w969lczb 246 18 ( ( -LRB- cord-329844-w969lczb 246 19 W W NNP cord-329844-w969lczb 246 20 ) ) -RRB- cord-329844-w969lczb 246 21 171 171 CD cord-329844-w969lczb 246 22 ( ( -LRB- cord-329844-w969lczb 246 23 donor donor NN cord-329844-w969lczb 246 24 ) ) -RRB- cord-329844-w969lczb 246 25 and and CC cord-329844-w969lczb 246 26 phenylalanine phenylalanine NN cord-329844-w969lczb 246 27 ( ( -LRB- cord-329844-w969lczb 246 28 F f NN cord-329844-w969lczb 246 29 ) ) -RRB- cord-329844-w969lczb 246 30 179 179 CD cord-329844-w969lczb 246 31 ( ( -LRB- cord-329844-w969lczb 246 32 acceptor acceptor NN cord-329844-w969lczb 246 33 ) ) -RRB- cord-329844-w969lczb 246 34 , , , cord-329844-w969lczb 246 35 alanine alanine NN cord-329844-w969lczb 246 36 ( ( -LRB- cord-329844-w969lczb 246 37 A a NN cord-329844-w969lczb 246 38 ) ) -RRB- cord-329844-w969lczb 246 39 210 210 CD cord-329844-w969lczb 246 40 ( ( -LRB- cord-329844-w969lczb 246 41 donor donor NN cord-329844-w969lczb 246 42 ) ) -RRB- cord-329844-w969lczb 246 43 and and CC cord-329844-w969lczb 246 44 phenylalanine phenylalanine NN cord-329844-w969lczb 246 45 ( ( -LRB- cord-329844-w969lczb 246 46 F F NNP cord-329844-w969lczb 246 47 ) ) -RRB- cord-329844-w969lczb 246 48 29 29 CD cord-329844-w969lczb 246 49 ( ( -LRB- cord-329844-w969lczb 246 50 acceptor acceptor NN cord-329844-w969lczb 246 51 ) ) -RRB- cord-329844-w969lczb 246 52 , , , cord-329844-w969lczb 246 53 leucine(L leucine(L NNP cord-329844-w969lczb 246 54 ) ) -RRB- cord-329844-w969lczb 246 55 209 209 CD cord-329844-w969lczb 246 56 ( ( -LRB- cord-329844-w969lczb 246 57 donor donor NN cord-329844-w969lczb 246 58 ) ) -RRB- cord-329844-w969lczb 246 59 and and CC cord-329844-w969lczb 246 60 tryptophan tryptophan NN cord-329844-w969lczb 246 61 ( ( -LRB- cord-329844-w969lczb 246 62 W w NN cord-329844-w969lczb 246 63 ) ) -RRB- cord-329844-w969lczb 246 64 171 171 CD cord-329844-w969lczb 246 65 ( ( -LRB- cord-329844-w969lczb 246 66 acceptor acceptor NN cord-329844-w969lczb 246 67 ) ) -RRB- cord-329844-w969lczb 246 68 . . . cord-329844-w969lczb 247 1 For for IN cord-329844-w969lczb 247 2 example example NN cord-329844-w969lczb 247 3 , , , cord-329844-w969lczb 247 4 tryptophan tryptophan NN cord-329844-w969lczb 247 5 accepted accept VBD cord-329844-w969lczb 247 6 one one CD cord-329844-w969lczb 247 7 N n CD cord-329844-w969lczb 247 8 - - HYPH cord-329844-w969lczb 247 9 H⋯π h⋯π NN cord-329844-w969lczb 247 10 bond bond NN cord-329844-w969lczb 247 11 from from IN cord-329844-w969lczb 247 12 Leucine Leucine NNP cord-329844-w969lczb 247 13 ( ( -LRB- cord-329844-w969lczb 247 14 L L NNP cord-329844-w969lczb 247 15 ) ) -RRB- cord-329844-w969lczb 247 16 209 209 CD cord-329844-w969lczb 247 17 and and CC cord-329844-w969lczb 247 18 donates donate VBZ cord-329844-w969lczb 247 19 one one CD cord-329844-w969lczb 247 20 N n CD cord-329844-w969lczb 247 21 - - HYPH cord-329844-w969lczb 247 22 H⋯π h⋯π NN cord-329844-w969lczb 247 23 bond bond NN cord-329844-w969lczb 247 24 to to IN cord-329844-w969lczb 247 25 phenylalanine phenylalanine NN cord-329844-w969lczb 247 26 179 179 CD cord-329844-w969lczb 247 27 . . . cord-329844-w969lczb 248 1 It -PRON- PRP cord-329844-w969lczb 248 2 is be VBZ cord-329844-w969lczb 248 3 possible possible JJ cord-329844-w969lczb 248 4 that that IN cord-329844-w969lczb 248 5 the the DT cord-329844-w969lczb 248 6 aromatic aromatic JJ cord-329844-w969lczb 248 7 residues residue NNS cord-329844-w969lczb 248 8 could could MD cord-329844-w969lczb 248 9 be be VB cord-329844-w969lczb 248 10 induced induce VBN cord-329844-w969lczb 248 11 to to TO cord-329844-w969lczb 248 12 be be VB cord-329844-w969lczb 248 13 more more RBR cord-329844-w969lczb 248 14 exposed expose VBN cord-329844-w969lczb 248 15 in in IN cord-329844-w969lczb 248 16 certain certain JJ cord-329844-w969lczb 248 17 types type NNS cord-329844-w969lczb 248 18 of of IN cord-329844-w969lczb 248 19 binding binding NN cord-329844-w969lczb 248 20 , , , cord-329844-w969lczb 248 21 but but CC cord-329844-w969lczb 248 22 the the DT cord-329844-w969lczb 248 23 above above JJ cord-329844-w969lczb 248 24 interactions interaction NNS cord-329844-w969lczb 248 25 appeared appear VBD cord-329844-w969lczb 248 26 to to TO cord-329844-w969lczb 248 27 stabilize stabilize VB cord-329844-w969lczb 248 28 the the DT cord-329844-w969lczb 248 29 structure structure NN cord-329844-w969lczb 248 30 of of IN cord-329844-w969lczb 248 31 S1 s1 NN cord-329844-w969lczb 248 32 fold fold NN cord-329844-w969lczb 248 33 motif motif NN cord-329844-w969lczb 248 34 while while IN cord-329844-w969lczb 248 35 reducing reduce VBG cord-329844-w969lczb 248 36 the the DT cord-329844-w969lczb 248 37 active active JJ cord-329844-w969lczb 248 38 site site NN cord-329844-w969lczb 248 39 cavity cavity NN cord-329844-w969lczb 248 40 for for IN cord-329844-w969lczb 248 41 ligand ligand NN cord-329844-w969lczb 248 42 binding bind VBG cord-329844-w969lczb 248 43 [ [ -LRB- cord-329844-w969lczb 248 44 13 13 CD cord-329844-w969lczb 248 45 ] ] -RRB- cord-329844-w969lczb 248 46 . . . cord-329844-w969lczb 249 1 Features feature NNS cord-329844-w969lczb 249 2 of of IN cord-329844-w969lczb 249 3 sialic sialic JJ cord-329844-w969lczb 249 4 acid acid NN cord-329844-w969lczb 249 5 glycan glycan NN cord-329844-w969lczb 249 6 binding bind VBG cord-329844-w969lczb 249 7 regions region NNS cord-329844-w969lczb 249 8 represented represent VBN cord-329844-w969lczb 249 9 by by IN cord-329844-w969lczb 249 10 a a DT cord-329844-w969lczb 249 11 run run NN cord-329844-w969lczb 249 12 of of IN cord-329844-w969lczb 249 13 amino amino NN cord-329844-w969lczb 249 14 acid acid NN cord-329844-w969lczb 249 15 residues residue NNS cord-329844-w969lczb 249 16 have have VBP cord-329844-w969lczb 249 17 diverse diverse JJ cord-329844-w969lczb 249 18 sequence sequence NN cord-329844-w969lczb 249 19 patterns pattern NNS cord-329844-w969lczb 249 20 , , , cord-329844-w969lczb 249 21 but but CC cord-329844-w969lczb 249 22 evidently evidently RB cord-329844-w969lczb 249 23 the the DT cord-329844-w969lczb 249 24 simple simple JJ cord-329844-w969lczb 249 25 presence presence NN cord-329844-w969lczb 249 26 of of IN cord-329844-w969lczb 249 27 the the DT cord-329844-w969lczb 249 28 above above JJ cord-329844-w969lczb 249 29 residues residue NNS cord-329844-w969lczb 249 30 in in IN cord-329844-w969lczb 249 31 a a DT cord-329844-w969lczb 249 32 section section NN cord-329844-w969lczb 249 33 of of IN cord-329844-w969lczb 249 34 sequence sequence NN cord-329844-w969lczb 249 35 is be VBZ cord-329844-w969lczb 249 36 itself -PRON- PRP cord-329844-w969lczb 249 37 a a DT cord-329844-w969lczb 249 38 strong strong JJ cord-329844-w969lczb 249 39 signal signal NN cord-329844-w969lczb 249 40 feature feature NN cord-329844-w969lczb 249 41 ; ; : cord-329844-w969lczb 249 42 this this DT cord-329844-w969lczb 249 43 seems seem VBZ cord-329844-w969lczb 249 44 particularly particularly RB cord-329844-w969lczb 249 45 so so RB cord-329844-w969lczb 249 46 for for IN cord-329844-w969lczb 249 47 tryptophan tryptophan NN cord-329844-w969lczb 249 48 . . . cord-329844-w969lczb 250 1 To to TO cord-329844-w969lczb 250 2 examine examine VB cord-329844-w969lczb 250 3 this this DT cord-329844-w969lczb 250 4 further further RB cord-329844-w969lczb 250 5 , , , cord-329844-w969lczb 250 6 many many JJ cord-329844-w969lczb 250 7 sequence sequence NN cord-329844-w969lczb 250 8 alignments alignment NNS cord-329844-w969lczb 250 9 were be VBD cord-329844-w969lczb 250 10 examined examine VBN cord-329844-w969lczb 250 11 that that WDT cord-329844-w969lczb 250 12 relate relate VBP cord-329844-w969lczb 250 13 to to IN cord-329844-w969lczb 250 14 role role NN cord-329844-w969lczb 250 15 of of IN cord-329844-w969lczb 250 16 the the DT cord-329844-w969lczb 250 17 aromatic aromatic JJ cord-329844-w969lczb 250 18 amino amino NN cord-329844-w969lczb 250 19 acids acid NNS cord-329844-w969lczb 250 20 and and CC cord-329844-w969lczb 250 21 the the DT cord-329844-w969lczb 250 22 contribution contribution NN cord-329844-w969lczb 250 23 of of IN cord-329844-w969lczb 250 24 tryptophan tryptophan NN cord-329844-w969lczb 250 25 to to IN cord-329844-w969lczb 250 26 known known JJ cord-329844-w969lczb 250 27 or or CC cord-329844-w969lczb 250 28 suspected suspect VBN cord-329844-w969lczb 250 29 sialic sialic JJ cord-329844-w969lczb 250 30 acid acid NN cord-329844-w969lczb 250 31 glycan glycan NN cord-329844-w969lczb 250 32 binding binding NN cord-329844-w969lczb 250 33 , , , cord-329844-w969lczb 250 34 and and CC cord-329844-w969lczb 250 35 these these DT cord-329844-w969lczb 250 36 were be VBD cord-329844-w969lczb 250 37 were be VBD cord-329844-w969lczb 250 38 investigated investigate VBN cord-329844-w969lczb 250 39 in in IN cord-329844-w969lczb 250 40 a a DT cord-329844-w969lczb 250 41 more more RBR cord-329844-w969lczb 250 42 quantitative quantitative JJ cord-329844-w969lczb 250 43 way way NN cord-329844-w969lczb 250 44 . . . cord-329844-w969lczb 251 1 For for IN cord-329844-w969lczb 251 2 example example NN cord-329844-w969lczb 251 3 , , , cord-329844-w969lczb 251 4 the the DT cord-329844-w969lczb 251 5 following follow VBG cord-329844-w969lczb 251 6 represent represent VBP cord-329844-w969lczb 251 7 a a DT cord-329844-w969lczb 251 8 summary summary NN cord-329844-w969lczb 251 9 of of IN cord-329844-w969lczb 251 10 influenza influenza NN cord-329844-w969lczb 251 11 subsequences subsequence NNS cord-329844-w969lczb 251 12 that that WDT cord-329844-w969lczb 251 13 contain contain VBP cord-329844-w969lczb 251 14 tryptophan tryptophan NN cord-329844-w969lczb 251 15 . . . cord-329844-w969lczb 252 1 With with IN cord-329844-w969lczb 252 2 it -PRON- PRP cord-329844-w969lczb 252 3 is be VBZ cord-329844-w969lczb 252 4 associated associate VBN cord-329844-w969lczb 252 5 the the DT cord-329844-w969lczb 252 6 preliminary preliminary JJ cord-329844-w969lczb 252 7 , , , cord-329844-w969lczb 252 8 essentially essentially RB cord-329844-w969lczb 252 9 qualitative qualitative JJ cord-329844-w969lczb 252 10 sialic sialic NN cord-329844-w969lczb 252 11 acid acid NN cord-329844-w969lczb 252 12 binding bind VBG cord-329844-w969lczb 252 13 residue residue NN cord-329844-w969lczb 252 14 score score NN cord-329844-w969lczb 252 15 ( ( -LRB- cord-329844-w969lczb 252 16 SAB SAB NNP cord-329844-w969lczb 252 17 - - HYPH cord-329844-w969lczb 252 18 S S NNP cord-329844-w969lczb 252 19 ) ) -RRB- cord-329844-w969lczb 252 20 discussed discuss VBD cord-329844-w969lczb 252 21 above above RB cord-329844-w969lczb 252 22 and and CC cord-329844-w969lczb 252 23 based base VBN cord-329844-w969lczb 252 24 on on IN cord-329844-w969lczb 252 25 observation observation NN cord-329844-w969lczb 252 26 of of IN cord-329844-w969lczb 252 27 multiple multiple JJ cord-329844-w969lczb 252 28 sugar sugar NN cord-329844-w969lczb 252 29 binding binding NN cord-329844-w969lczb 252 30 sites site NNS cord-329844-w969lczb 252 31 and and CC cord-329844-w969lczb 252 32 literature literature NN cord-329844-w969lczb 252 33 survey survey NN cord-329844-w969lczb 252 34 , , , cord-329844-w969lczb 252 35 to to IN cord-329844-w969lczb 252 36 each each DT cord-329844-w969lczb 252 37 of of IN cord-329844-w969lczb 252 38 the the DT cord-329844-w969lczb 252 39 amino amino NN cord-329844-w969lczb 252 40 acids acid NNS cord-329844-w969lczb 252 41 mentioned mention VBN cord-329844-w969lczb 252 42 above above RB cord-329844-w969lczb 252 43 . . . cord-329844-w969lczb 253 1 At at IN cord-329844-w969lczb 253 2 this this DT cord-329844-w969lczb 253 3 stage stage NN cord-329844-w969lczb 253 4 , , , cord-329844-w969lczb 253 5 there there EX cord-329844-w969lczb 253 6 is be VBZ cord-329844-w969lczb 253 7 no no DT cord-329844-w969lczb 253 8 significant significant JJ cord-329844-w969lczb 253 9 algorithm algorithm NN cord-329844-w969lczb 253 10 except except IN cord-329844-w969lczb 253 11 that that IN cord-329844-w969lczb 253 12 the the DT cord-329844-w969lczb 253 13 sum sum NN cord-329844-w969lczb 253 14 of of IN cord-329844-w969lczb 253 15 scores score NNS cord-329844-w969lczb 253 16 over over IN cord-329844-w969lczb 253 17 the the DT cord-329844-w969lczb 253 18 residues residue NNS cord-329844-w969lczb 253 19 in in IN cord-329844-w969lczb 253 20 the the DT cord-329844-w969lczb 253 21 short short JJ cord-329844-w969lczb 253 22 sequence sequence NN cord-329844-w969lczb 253 23 is be VBZ cord-329844-w969lczb 253 24 divided divide VBN cord-329844-w969lczb 253 25 by by IN cord-329844-w969lczb 253 26 the the DT cord-329844-w969lczb 253 27 number number NN cord-329844-w969lczb 253 28 of of IN cord-329844-w969lczb 253 29 residues residue NNS cord-329844-w969lczb 253 30 ( ( -LRB- cord-329844-w969lczb 253 31 mostly mostly RB cord-329844-w969lczb 253 32 16 16 CD cord-329844-w969lczb 253 33 or or CC cord-329844-w969lczb 253 34 17 17 CD cord-329844-w969lczb 253 35 ) ) -RRB- cord-329844-w969lczb 253 36 so so IN cord-329844-w969lczb 253 37 that that IN cord-329844-w969lczb 253 38 it -PRON- PRP cord-329844-w969lczb 253 39 expressed express VBD cord-329844-w969lczb 253 40 on on IN cord-329844-w969lczb 253 41 an an DT cord-329844-w969lczb 253 42 averaged average VBN cord-329844-w969lczb 253 43 , , , cord-329844-w969lczb 253 44 per per IN cord-329844-w969lczb 253 45 residue residue NN cord-329844-w969lczb 253 46 , , , cord-329844-w969lczb 253 47 basis basis NN cord-329844-w969lczb 253 48 for for IN cord-329844-w969lczb 253 49 that that DT cord-329844-w969lczb 253 50 sequence sequence NN cord-329844-w969lczb 253 51 . . . cord-329844-w969lczb 254 1 Recall recall VB cord-329844-w969lczb 254 2 that that IN cord-329844-w969lczb 254 3 it -PRON- PRP cord-329844-w969lczb 254 4 is be VBZ cord-329844-w969lczb 254 5 qualitative qualitative JJ cord-329844-w969lczb 254 6 that that IN cord-329844-w969lczb 254 7 the the DT cord-329844-w969lczb 254 8 amino amino NN cord-329844-w969lczb 254 9 acid acid NN cord-329844-w969lczb 254 10 residues residue NNS cord-329844-w969lczb 254 11 are be VBP cord-329844-w969lczb 254 12 given give VBN cord-329844-w969lczb 254 13 a a DT cord-329844-w969lczb 254 14 score score NN cord-329844-w969lczb 254 15 of of IN cord-329844-w969lczb 254 16 1 1 CD cord-329844-w969lczb 254 17 ( ( -LRB- cord-329844-w969lczb 254 18 and and CC cord-329844-w969lczb 254 19 0 0 NFP cord-329844-w969lczb 254 20 otherwise otherwise RB cord-329844-w969lczb 254 21 ) ) -RRB- cord-329844-w969lczb 254 22 , , , cord-329844-w969lczb 254 23 except except IN cord-329844-w969lczb 254 24 that that DT cord-329844-w969lczb 254 25 tryptophan tryptophan NN cord-329844-w969lczb 254 26 is be VBZ cord-329844-w969lczb 254 27 given give VBN cord-329844-w969lczb 254 28 an an DT cord-329844-w969lczb 254 29 extra extra JJ cord-329844-w969lczb 254 30 weight weight NN cord-329844-w969lczb 254 31 of of IN cord-329844-w969lczb 254 32 2 2 CD cord-329844-w969lczb 254 33 . . . cord-329844-w969lczb 255 1 In in IN cord-329844-w969lczb 255 2 many many JJ cord-329844-w969lczb 255 3 cases case NNS cord-329844-w969lczb 255 4 the the DT cord-329844-w969lczb 255 5 sidechain sidechain NN cord-329844-w969lczb 255 6 is be VBZ cord-329844-w969lczb 255 7 involved involve VBN cord-329844-w969lczb 255 8 , , , cord-329844-w969lczb 255 9 especially especially RB cord-329844-w969lczb 255 10 for for IN cord-329844-w969lczb 255 11 the the DT cord-329844-w969lczb 255 12 aromatic aromatic JJ cord-329844-w969lczb 255 13 residues residue NNS cord-329844-w969lczb 255 14 , , , cord-329844-w969lczb 255 15 but but CC cord-329844-w969lczb 255 16 this this DT cord-329844-w969lczb 255 17 not not RB cord-329844-w969lczb 255 18 obligatory obligatory JJ cord-329844-w969lczb 255 19 : : : cord-329844-w969lczb 255 20 it -PRON- PRP cord-329844-w969lczb 255 21 could could MD cord-329844-w969lczb 255 22 be be VB cord-329844-w969lczb 255 23 a a DT cord-329844-w969lczb 255 24 backbone backbone NN cord-329844-w969lczb 255 25 interaction interaction NN cord-329844-w969lczb 255 26 ( ( -LRB- cord-329844-w969lczb 255 27 as as IN cord-329844-w969lczb 255 28 is be VBZ cord-329844-w969lczb 255 29 necessary necessary JJ cord-329844-w969lczb 255 30 for for IN cord-329844-w969lczb 255 31 glycine glycine NN cord-329844-w969lczb 255 32 ( ( -LRB- cord-329844-w969lczb 255 33 G g NN cord-329844-w969lczb 255 34 ) ) -RRB- cord-329844-w969lczb 255 35 that that WDT cord-329844-w969lczb 255 36 lacks lack VBZ cord-329844-w969lczb 255 37 a a DT cord-329844-w969lczb 255 38 sidechain sidechain NN cord-329844-w969lczb 255 39 ) ) -RRB- cord-329844-w969lczb 255 40 . . . cord-329844-w969lczb 256 1 This this DT cord-329844-w969lczb 256 2 is be VBZ cord-329844-w969lczb 256 3 the the DT cord-329844-w969lczb 256 4 " " `` cord-329844-w969lczb 256 5 qualitative qualitative JJ cord-329844-w969lczb 256 6 " " '' cord-329844-w969lczb 256 7 model model NN cord-329844-w969lczb 256 8 that that WDT cord-329844-w969lczb 256 9 was be VBD cord-329844-w969lczb 256 10 shown show VBN cord-329844-w969lczb 256 11 in in IN cord-329844-w969lczb 256 12 Table Table NNP cord-329844-w969lczb 256 13 1 1 CD cord-329844-w969lczb 256 14 , , , cord-329844-w969lczb 256 15 which which WDT cord-329844-w969lczb 256 16 will will MD cord-329844-w969lczb 256 17 be be VB cord-329844-w969lczb 256 18 extended extend VBN cord-329844-w969lczb 256 19 to to IN cord-329844-w969lczb 256 20 the the DT cord-329844-w969lczb 256 21 SABR SABR NNP cord-329844-w969lczb 256 22 - - HYPH cord-329844-w969lczb 256 23 P p NN cord-329844-w969lczb 256 24 method method NN cord-329844-w969lczb 256 25 later later RB cord-329844-w969lczb 256 26 below below RB cord-329844-w969lczb 256 27 . . . cord-329844-w969lczb 257 1 There there EX cord-329844-w969lczb 257 2 is be VBZ cord-329844-w969lczb 257 3 in in IN cord-329844-w969lczb 257 4 the the DT cord-329844-w969lczb 257 5 following follow VBG cord-329844-w969lczb 257 6 an an DT cord-329844-w969lczb 257 7 attempt attempt NN cord-329844-w969lczb 257 8 at at IN cord-329844-w969lczb 257 9 local local JJ cord-329844-w969lczb 257 10 alignment alignment NN cord-329844-w969lczb 257 11 to to TO cord-329844-w969lczb 257 12 highlight highlight VB cord-329844-w969lczb 257 13 similar similar JJ cord-329844-w969lczb 257 14 features feature NNS cord-329844-w969lczb 257 15 because because IN cord-329844-w969lczb 257 16 there there EX cord-329844-w969lczb 257 17 is be VBZ cord-329844-w969lczb 257 18 often often RB cord-329844-w969lczb 257 19 some some DT cord-329844-w969lczb 257 20 indication indication NN cord-329844-w969lczb 257 21 that that IN cord-329844-w969lczb 257 22 a a DT cord-329844-w969lczb 257 23 motif motif NN cord-329844-w969lczb 257 24 is be VBZ cord-329844-w969lczb 257 25 reused reuse VBN cord-329844-w969lczb 257 26 even even RB cord-329844-w969lczb 257 27 within within IN cord-329844-w969lczb 257 28 a a DT cord-329844-w969lczb 257 29 protein protein NN cord-329844-w969lczb 257 30 , , , cord-329844-w969lczb 257 31 although although IN cord-329844-w969lczb 257 32 that that DT cord-329844-w969lczb 257 33 assertion assertion NN cord-329844-w969lczb 257 34 is be VBZ cord-329844-w969lczb 257 35 not not RB cord-329844-w969lczb 257 36 required require VBN cord-329844-w969lczb 257 37 for for IN cord-329844-w969lczb 257 38 present present JJ cord-329844-w969lczb 257 39 purposes purpose NNS cord-329844-w969lczb 257 40 . . . cord-329844-w969lczb 258 1 The the DT cord-329844-w969lczb 258 2 sum sum NN cord-329844-w969lczb 258 3 of of IN cord-329844-w969lczb 258 4 score score NN cord-329844-w969lczb 258 5 is be VBZ cord-329844-w969lczb 258 6 divided divide VBN cord-329844-w969lczb 258 7 by by IN cord-329844-w969lczb 258 8 the the DT cord-329844-w969lczb 258 9 sequence sequence NN cord-329844-w969lczb 258 10 length length NN cord-329844-w969lczb 258 11 that that WDT cord-329844-w969lczb 258 12 excludes exclude VBZ cord-329844-w969lczb 258 13 relative relative JJ cord-329844-w969lczb 258 14 deletions deletion NNS cord-329844-w969lczb 258 15 ' ' POS cord-329844-w969lczb 258 16 - - HYPH cord-329844-w969lczb 258 17 ' ' '' cord-329844-w969lczb 258 18 . . . cord-329844-w969lczb 259 1 Many many JJ cord-329844-w969lczb 259 2 hemaglutanin hemaglutanin NNS cord-329844-w969lczb 259 3 and and CC cord-329844-w969lczb 259 4 neuraminidase neuraminidase NN cord-329844-w969lczb 259 5 matches match NNS cord-329844-w969lczb 259 6 were be VBD cord-329844-w969lczb 259 7 found find VBN cord-329844-w969lczb 259 8 with with IN cord-329844-w969lczb 259 9 SSSGWTAGAAAYY SSSGWTAGAAAYY NNP cord-329844-w969lczb 259 10 using use VBG cord-329844-w969lczb 259 11 BLASTp BLASTp NNS cord-329844-w969lczb 259 12 , , , cord-329844-w969lczb 259 13 the the DT cord-329844-w969lczb 259 14 top top JJ cord-329844-w969lczb 259 15 100 100 CD cord-329844-w969lczb 259 16 varying vary VBG cord-329844-w969lczb 259 17 from from IN cord-329844-w969lczb 259 18 64 64 CD cord-329844-w969lczb 259 19 % % NN cord-329844-w969lczb 259 20 match match NN cord-329844-w969lczb 259 21 and and CC cord-329844-w969lczb 259 22 63 63 CD cord-329844-w969lczb 259 23 % % NN cord-329844-w969lczb 259 24 identities identity NNS cord-329844-w969lczb 259 25 that that WDT cord-329844-w969lczb 259 26 preserve preserve VBP cord-329844-w969lczb 259 27 the the DT cord-329844-w969lczb 259 28 tryptophan tryptophan NN cord-329844-w969lczb 259 29 , , , cord-329844-w969lczb 259 30 such such JJ cord-329844-w969lczb 259 31 as as IN cord-329844-w969lczb 259 32 hemagglutinin hemagglutinin NN cord-329844-w969lczb 259 33 Influenza Influenza NNP cord-329844-w969lczb 259 34 A a DT cord-329844-w969lczb 259 35 virus virus NN cord-329844-w969lczb 259 36 , , , cord-329844-w969lczb 259 37 GenBank GenBank NNP cord-329844-w969lczb 259 38 AXB35920.1 AXB35920.1 NNP cord-329844-w969lczb 259 39 SSGW SSGW NNP cord-329844-w969lczb 259 40 -- -- : cord-329844-w969lczb 259 41 GAVN GAVN NNP cord-329844-w969lczb 259 42 , , , cord-329844-w969lczb 259 43 and and CC cord-329844-w969lczb 259 44 neuraminidase neuraminidase NN cord-329844-w969lczb 259 45 , , , cord-329844-w969lczb 259 46 Influenza Influenza NNP cord-329844-w969lczb 259 47 A a DT cord-329844-w969lczb 259 48 virus virus NN cord-329844-w969lczb 259 49 AFK13818.1 AFK13818.1 NNP cord-329844-w969lczb 259 50 SGW----AAY sgw----aay NN cord-329844-w969lczb 259 51 , , , cord-329844-w969lczb 259 52 and and CC cord-329844-w969lczb 259 53 neuraminidase neuraminidase NN cord-329844-w969lczb 259 54 , , , cord-329844-w969lczb 260 1 Influenza Influenza NNP cord-329844-w969lczb 260 2 A a DT cord-329844-w969lczb 260 3 virus virus NN cord-329844-w969lczb 260 4 ANZ90284.1 ANZ90284.1 NNP cord-329844-w969lczb 260 5 , , , cord-329844-w969lczb 260 6 SSAWSASA SSAWSASA NNP cord-329844-w969lczb 260 7 . . . cord-329844-w969lczb 261 1 Looking look VBG cord-329844-w969lczb 261 2 at at IN cord-329844-w969lczb 261 3 the the DT cord-329844-w969lczb 261 4 larger large JJR cord-329844-w969lczb 261 5 sequence sequence NN cord-329844-w969lczb 261 6 context context NN cord-329844-w969lczb 261 7 , , , cord-329844-w969lczb 261 8 95 95 CD cord-329844-w969lczb 261 9 % % NN cord-329844-w969lczb 261 10 of of IN cord-329844-w969lczb 261 11 these these DT cord-329844-w969lczb 261 12 scored score VBN cord-329844-w969lczb 261 13 over over IN cord-329844-w969lczb 261 14 0.75 0.75 CD cord-329844-w969lczb 261 15 on on IN cord-329844-w969lczb 261 16 the the DT cord-329844-w969lczb 261 17 above above JJ cord-329844-w969lczb 261 18 system system NN cord-329844-w969lczb 261 19 . . . cord-329844-w969lczb 262 1 However however RB cord-329844-w969lczb 262 2 , , , cord-329844-w969lczb 262 3 nucleocapsid nucleocapsid NN cord-329844-w969lczb 262 4 proteins protein NNS cord-329844-w969lczb 262 5 of of IN cord-329844-w969lczb 262 6 Influenza Influenza NNP cord-329844-w969lczb 262 7 A a DT cord-329844-w969lczb 262 8 virus virus NN cord-329844-w969lczb 262 9 such such JJ cord-329844-w969lczb 262 10 as as IN cord-329844-w969lczb 262 11 sequence sequence NN cord-329844-w969lczb 262 12 QIQ4588 QIQ4588 NNP cord-329844-w969lczb 262 13 with with IN cord-329844-w969lczb 262 14 SG SG NNP cord-329844-w969lczb 262 15 - - HYPH cord-329844-w969lczb 262 16 TAGAA TAGAA NNP cord-329844-w969lczb 262 17 and and CC cord-329844-w969lczb 262 18 AAZ08011.1 AAZ08011.1 NNP cord-329844-w969lczb 262 19 as as IN cord-329844-w969lczb 262 20 STSG STSG NNP cord-329844-w969lczb 262 21 - - HYPH cord-329844-w969lczb 262 22 AAGAA AAGAA NNP cord-329844-w969lczb 262 23 also also RB cord-329844-w969lczb 262 24 appear appear VBP cord-329844-w969lczb 262 25 in in IN cord-329844-w969lczb 262 26 the the DT cord-329844-w969lczb 262 27 top top JJ cord-329844-w969lczb 262 28 100 100 CD cord-329844-w969lczb 262 29 matches match NNS cord-329844-w969lczb 262 30 along along IN cord-329844-w969lczb 262 31 with with IN cord-329844-w969lczb 262 32 the the DT cord-329844-w969lczb 262 33 above above JJ cord-329844-w969lczb 262 34 and and CC cord-329844-w969lczb 262 35 with with IN cord-329844-w969lczb 262 36 comparable comparable JJ cord-329844-w969lczb 262 37 scores score NNS cord-329844-w969lczb 262 38 , , , cord-329844-w969lczb 262 39 but but CC cord-329844-w969lczb 262 40 with with IN cord-329844-w969lczb 262 41 one one CD cord-329844-w969lczb 262 42 obvious obvious JJ cord-329844-w969lczb 262 43 and and CC cord-329844-w969lczb 262 44 significant significant JJ cord-329844-w969lczb 262 45 difference difference NN cord-329844-w969lczb 262 46 , , , cord-329844-w969lczb 262 47 that that IN cord-329844-w969lczb 262 48 the the DT cord-329844-w969lczb 262 49 tryptophan tryptophan NN cord-329844-w969lczb 262 50 ( ( -LRB- cord-329844-w969lczb 262 51 W W NNP cord-329844-w969lczb 262 52 ) ) -RRB- cord-329844-w969lczb 262 53 is be VBZ cord-329844-w969lczb 262 54 missing miss VBG cord-329844-w969lczb 262 55 . . . cord-329844-w969lczb 263 1 The the DT cord-329844-w969lczb 263 2 possible possible JJ cord-329844-w969lczb 263 3 importance importance NN cord-329844-w969lczb 263 4 of of IN cord-329844-w969lczb 263 5 tryptophan tryptophan NN cord-329844-w969lczb 263 6 in in IN cord-329844-w969lczb 263 7 binding bind VBG cord-329844-w969lczb 263 8 in in IN cord-329844-w969lczb 263 9 SARS SARS NNP cord-329844-w969lczb 263 10 - - HYPH cord-329844-w969lczb 263 11 CoV-2 CoV-2 NNP cord-329844-w969lczb 263 12 is be VBZ cord-329844-w969lczb 263 13 exemplified exemplify VBN cord-329844-w969lczb 263 14 in in IN cord-329844-w969lczb 263 15 the the DT cord-329844-w969lczb 263 16 following following JJ cord-329844-w969lczb 263 17 sequence sequence NN cord-329844-w969lczb 263 18 of of IN cord-329844-w969lczb 263 19 the the DT cord-329844-w969lczb 263 20 SARS SARS NNP cord-329844-w969lczb 263 21 - - HYPH cord-329844-w969lczb 263 22 CoV-2 CoV-2 NNP cord-329844-w969lczb 263 23 S1-NTD S1-NTD NNP cord-329844-w969lczb 263 24 section section NN cord-329844-w969lczb 263 25 of of IN cord-329844-w969lczb 263 26 the the DT cord-329844-w969lczb 263 27 spike spike NN cord-329844-w969lczb 263 28 glycoprotein glycoprotein NN cord-329844-w969lczb 263 29 ( ( -LRB- cord-329844-w969lczb 263 30 including include VBG cord-329844-w969lczb 263 31 the the DT cord-329844-w969lczb 263 32 signal signal NN cord-329844-w969lczb 263 33 peptide peptide NN cord-329844-w969lczb 263 34 , , , cord-329844-w969lczb 263 35 in in IN cord-329844-w969lczb 263 36 order order NN cord-329844-w969lczb 263 37 to to TO cord-329844-w969lczb 263 38 conserve conserve VB cord-329844-w969lczb 263 39 standard standard JJ cord-329844-w969lczb 263 40 numbering numbering NN cord-329844-w969lczb 263 41 ) ) -RRB- cord-329844-w969lczb 263 42 . . . cord-329844-w969lczb 264 1 The the DT cord-329844-w969lczb 264 2 sequence sequence NN cord-329844-w969lczb 264 3 is be VBZ cord-329844-w969lczb 264 4 from from IN cord-329844-w969lczb 264 5 the the DT cord-329844-w969lczb 264 6 S1-NTD S1-NTD NNP cord-329844-w969lczb 264 7 of of IN cord-329844-w969lczb 264 8 SARS SARS NNP cord-329844-w969lczb 264 9 - - HYPH cord-329844-w969lczb 264 10 CoV-2 CoV-2 NNP cord-329844-w969lczb 264 11 GenBank GenBank NNP cord-329844-w969lczb 264 12 entry entry NN cord-329844-w969lczb 264 13 MN908947.3 MN908947.3 NNP cord-329844-w969lczb 264 14 , , , cord-329844-w969lczb 264 15 along along IN cord-329844-w969lczb 264 16 with with IN cord-329844-w969lczb 264 17 a a DT cord-329844-w969lczb 264 18 brief brief JJ cord-329844-w969lczb 264 19 description description NN cord-329844-w969lczb 264 20 of of IN cord-329844-w969lczb 264 21 accessibility accessibility NN cord-329844-w969lczb 264 22 in in IN cord-329844-w969lczb 264 23 PDB PDB NNP cord-329844-w969lczb 264 24 entry entry NN cord-329844-w969lczb 264 25 6VVX 6vvx CD cord-329844-w969lczb 264 26 , , , cord-329844-w969lczb 264 27 which which WDT cord-329844-w969lczb 264 28 is be VBZ cord-329844-w969lczb 264 29 for for IN cord-329844-w969lczb 264 30 the the DT cord-329844-w969lczb 264 31 spike spike NN cord-329844-w969lczb 264 32 protein protein NN cord-329844-w969lczb 264 33 in in IN cord-329844-w969lczb 264 34 the the DT cord-329844-w969lczb 264 35 closed closed JJ cord-329844-w969lczb 264 36 state state NN cord-329844-w969lczb 264 37 . . . cord-329844-w969lczb 265 1 TRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHV TRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHV NNP cord-329844-w969lczb 265 2 60 60 CD cord-329844-w969lczb 265 3 - - SYM cord-329844-w969lczb 265 4 70 70 CD cord-329844-w969lczb 265 5 W w NN cord-329844-w969lczb 265 6 exposed expose VBN cord-329844-w969lczb 265 7 SGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPF SGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPF NNP cord-329844-w969lczb 265 8 112 112 CD cord-329844-w969lczb 265 9 - - HYPH cord-329844-w969lczb 265 10 124 124 CD cord-329844-w969lczb 265 11 cleft cleft NN cord-329844-w969lczb 265 12 LGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPI LGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPI NNP cord-329844-w969lczb 265 13 147 147 CD cord-329844-w969lczb 265 14 - - SYM cord-329844-w969lczb 265 15 160 160 CD cord-329844-w969lczb 265 16 disord disord NNS cord-329844-w969lczb 265 17 . . . cord-329844-w969lczb 266 1 NLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYN NLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYN NNP cord-329844-w969lczb 266 2 253 253 CD cord-329844-w969lczb 266 3 - - SYM cord-329844-w969lczb 266 4 265 265 CD cord-329844-w969lczb 266 5 disord disord NN cord-329844-w969lczb 266 6 . . . cord-329844-w969lczb 267 1 ENGTIT ENGTIT NNP cord-329844-w969lczb 267 2 Here here RB cord-329844-w969lczb 267 3 , , , cord-329844-w969lczb 267 4 " " '' cord-329844-w969lczb 267 5 disord disord NNP cord-329844-w969lczb 267 6 . . . cord-329844-w969lczb 267 7 " " '' cord-329844-w969lczb 267 8 means mean VBZ cord-329844-w969lczb 267 9 a a DT cord-329844-w969lczb 267 10 disordered disordered JJ cord-329844-w969lczb 267 11 ( ( -LRB- cord-329844-w969lczb 267 12 flexible flexible JJ cord-329844-w969lczb 267 13 ) ) -RRB- cord-329844-w969lczb 267 14 loop loop NN cord-329844-w969lczb 267 15 : : : cord-329844-w969lczb 267 16 the the DT cord-329844-w969lczb 267 17 tryptophan tryptophan NN cord-329844-w969lczb 267 18 ( ( -LRB- cord-329844-w969lczb 267 19 W W NNP cord-329844-w969lczb 267 20 ) ) -RRB- cord-329844-w969lczb 267 21 and and CC cord-329844-w969lczb 267 22 adjacent adjacent JJ cord-329844-w969lczb 267 23 residues residue NNS cord-329844-w969lczb 267 24 are be VBP cord-329844-w969lczb 267 25 not not RB cord-329844-w969lczb 267 26 seen see VBN cord-329844-w969lczb 267 27 in in IN cord-329844-w969lczb 267 28 the the DT cord-329844-w969lczb 267 29 experimental experimental JJ cord-329844-w969lczb 267 30 3D 3D NNP cord-329844-w969lczb 267 31 structure structure NN cord-329844-w969lczb 267 32 determination determination NN cord-329844-w969lczb 267 33 6VVX 6vvx CD cord-329844-w969lczb 267 34 . . . cord-329844-w969lczb 268 1 This this DT cord-329844-w969lczb 268 2 is be VBZ cord-329844-w969lczb 268 3 also also RB cord-329844-w969lczb 268 4 true true JJ cord-329844-w969lczb 268 5 of of IN cord-329844-w969lczb 268 6 PDB PDB NNP cord-329844-w969lczb 268 7 entry entry NN cord-329844-w969lczb 268 8 6VSB 6vsb LS cord-329844-w969lczb 268 9 the the DT cord-329844-w969lczb 268 10 spike spike NN cord-329844-w969lczb 268 11 protein protein NN cord-329844-w969lczb 268 12 in in IN cord-329844-w969lczb 268 13 the the DT cord-329844-w969lczb 268 14 open open JJ cord-329844-w969lczb 268 15 state state NN cord-329844-w969lczb 268 16 , , , cord-329844-w969lczb 268 17 6VYB 6vyb JJ cord-329844-w969lczb 268 18 and and CC cord-329844-w969lczb 268 19 other other JJ cord-329844-w969lczb 268 20 SARS SARS NNP cord-329844-w969lczb 268 21 - - HYPH cord-329844-w969lczb 268 22 CoV-2 CoV-2 NNP cord-329844-w969lczb 268 23 accessible accessible JJ cord-329844-w969lczb 268 24 to to IN cord-329844-w969lczb 268 25 the the DT cord-329844-w969lczb 268 26 author author NN cord-329844-w969lczb 268 27 at at IN cord-329844-w969lczb 268 28 the the DT cord-329844-w969lczb 268 29 time time NN cord-329844-w969lczb 268 30 of of IN cord-329844-w969lczb 268 31 writing writing NN cord-329844-w969lczb 268 32 . . . cord-329844-w969lczb 269 1 See see VB cord-329844-w969lczb 269 2 Fig Fig NNP cord-329844-w969lczb 269 3 . . . cord-329844-w969lczb 270 1 3 3 LS cord-329844-w969lczb 270 2 . . . cord-329844-w969lczb 271 1 The the DT cord-329844-w969lczb 271 2 fact fact NN cord-329844-w969lczb 271 3 that that IN cord-329844-w969lczb 271 4 disordered disordered JJ cord-329844-w969lczb 271 5 suggest suggest VBP cord-329844-w969lczb 271 6 an an DT cord-329844-w969lczb 271 7 open open JJ cord-329844-w969lczb 271 8 loop loop NN cord-329844-w969lczb 271 9 like like IN cord-329844-w969lczb 271 10 structure structure NN cord-329844-w969lczb 271 11 that that WDT cord-329844-w969lczb 271 12 be be VB cord-329844-w969lczb 271 13 may may MD cord-329844-w969lczb 271 14 be be VB cord-329844-w969lczb 271 15 capable capable JJ cord-329844-w969lczb 271 16 of of IN cord-329844-w969lczb 271 17 binding bind VBG cord-329844-w969lczb 271 18 to to IN cord-329844-w969lczb 271 19 , , , cord-329844-w969lczb 271 20 and and CC cord-329844-w969lczb 271 21 perhaps perhaps RB cord-329844-w969lczb 271 22 adjusting adjust VBG cord-329844-w969lczb 271 23 to to IN cord-329844-w969lczb 271 24 , , , cord-329844-w969lczb 271 25 disordered disordered JJ cord-329844-w969lczb 271 26 targets target NNS cord-329844-w969lczb 271 27 , , , cord-329844-w969lczb 271 28 and and CC cord-329844-w969lczb 271 29 certainly certainly RB cord-329844-w969lczb 271 30 does do VBZ cord-329844-w969lczb 271 31 not not RB cord-329844-w969lczb 271 32 prohibit prohibit VB cord-329844-w969lczb 271 33 functional functional JJ cord-329844-w969lczb 271 34 significance significance NN cord-329844-w969lczb 271 35 . . . cord-329844-w969lczb 272 1 The the DT cord-329844-w969lczb 272 2 following following JJ cord-329844-w969lczb 272 3 summary summary NN cord-329844-w969lczb 272 4 Table table NN cord-329844-w969lczb 272 5 2 2 CD cord-329844-w969lczb 272 6 has have VBZ cord-329844-w969lczb 272 7 comments comment NNS cord-329844-w969lczb 272 8 on on IN cord-329844-w969lczb 272 9 the the DT cord-329844-w969lczb 272 10 status status NN cord-329844-w969lczb 272 11 of of IN cord-329844-w969lczb 272 12 exposure exposure NN cord-329844-w969lczb 272 13 of of IN cord-329844-w969lczb 272 14 the the DT cord-329844-w969lczb 272 15 tryptophan tryptophan NN cord-329844-w969lczb 272 16 and and CC cord-329844-w969lczb 272 17 surrounding surround VBG cord-329844-w969lczb 272 18 residues residue NNS cord-329844-w969lczb 272 19 , , , cord-329844-w969lczb 272 20 and and CC cord-329844-w969lczb 272 21 on on IN cord-329844-w969lczb 272 22 the the DT cord-329844-w969lczb 272 23 involvement involvement NN cord-329844-w969lczb 272 24 in in IN cord-329844-w969lczb 272 25 binding bind VBG cord-329844-w969lczb 272 26 based base VBN cord-329844-w969lczb 272 27 on on IN cord-329844-w969lczb 272 28 alignments alignment NNS cord-329844-w969lczb 272 29 with with IN cord-329844-w969lczb 272 30 the the DT cord-329844-w969lczb 272 31 Zhang Zhang NNP cord-329844-w969lczb 272 32 - - HYPH cord-329844-w969lczb 272 33 Yap Yap NNP cord-329844-w969lczb 272 34 analysis analysis NN cord-329844-w969lczb 272 35 . . . cord-329844-w969lczb 272 36 _SP cord-329844-w969lczb 273 1 Evidently evidently RB cord-329844-w969lczb 273 2 the the DT cord-329844-w969lczb 273 3 above above JJ cord-329844-w969lczb 273 4 is be VBZ cord-329844-w969lczb 273 5 not not RB cord-329844-w969lczb 273 6 perfect perfect JJ cord-329844-w969lczb 273 7 as as IN cord-329844-w969lczb 273 8 a a DT cord-329844-w969lczb 273 9 basis basis NN cord-329844-w969lczb 273 10 for for IN cord-329844-w969lczb 273 11 a a DT cord-329844-w969lczb 273 12 prediction prediction NN cord-329844-w969lczb 273 13 method method NN cord-329844-w969lczb 273 14 , , , cord-329844-w969lczb 273 15 and and CC cord-329844-w969lczb 273 16 the the DT cord-329844-w969lczb 273 17 next next JJ cord-329844-w969lczb 273 18 step step NN cord-329844-w969lczb 273 19 in in IN cord-329844-w969lczb 273 20 this this DT cord-329844-w969lczb 273 21 study study NN cord-329844-w969lczb 273 22 required require VBD cord-329844-w969lczb 273 23 more more RBR cord-329844-w969lczb 273 24 detailed detailed JJ cord-329844-w969lczb 273 25 considerations consideration NNS cord-329844-w969lczb 273 26 . . . cord-329844-w969lczb 274 1 it -PRON- PRP cord-329844-w969lczb 274 2 also also RB cord-329844-w969lczb 274 3 required require VBD cord-329844-w969lczb 274 4 a a DT cord-329844-w969lczb 274 5 more more RBR cord-329844-w969lczb 274 6 comprehensive comprehensive JJ cord-329844-w969lczb 274 7 analysis analysis NN cord-329844-w969lczb 274 8 of of IN cord-329844-w969lczb 274 9 predictive predictive JJ cord-329844-w969lczb 274 10 capability capability NN cord-329844-w969lczb 274 11 that that WDT cord-329844-w969lczb 274 12 allows allow VBZ cord-329844-w969lczb 274 13 for for IN cord-329844-w969lczb 274 14 false false JJ cord-329844-w969lczb 274 15 positives positive NNS cord-329844-w969lczb 274 16 and and CC cord-329844-w969lczb 274 17 false false JJ cord-329844-w969lczb 274 18 negatives negative NNS cord-329844-w969lczb 274 19 . . . cord-329844-w969lczb 275 1 The the DT cord-329844-w969lczb 275 2 method method NN cord-329844-w969lczb 275 3 developed develop VBN cord-329844-w969lczb 275 4 here here RB cord-329844-w969lczb 275 5 takes take VBZ cord-329844-w969lczb 275 6 account account NN cord-329844-w969lczb 275 7 of of IN cord-329844-w969lczb 275 8 the the DT cord-329844-w969lczb 275 9 above above JJ cord-329844-w969lczb 275 10 results result NNS cord-329844-w969lczb 275 11 in in IN cord-329844-w969lczb 275 12 the the DT cord-329844-w969lczb 275 13 light light NN cord-329844-w969lczb 275 14 of of IN cord-329844-w969lczb 275 15 several several JJ cord-329844-w969lczb 275 16 pieces piece NNS cord-329844-w969lczb 275 17 of of IN cord-329844-w969lczb 275 18 experimental experimental JJ cord-329844-w969lczb 275 19 and and CC cord-329844-w969lczb 275 20 theoretical theoretical JJ cord-329844-w969lczb 275 21 evidence evidence NN cord-329844-w969lczb 275 22 , , , cord-329844-w969lczb 275 23 which which WDT cord-329844-w969lczb 275 24 is be VBZ cord-329844-w969lczb 275 25 usefully usefully RB cord-329844-w969lczb 275 26 briefly briefly NN cord-329844-w969lczb 275 27 reviewed review VBN cord-329844-w969lczb 275 28 at at IN cord-329844-w969lczb 275 29 this this DT cord-329844-w969lczb 275 30 point point NN cord-329844-w969lczb 275 31 in in IN cord-329844-w969lczb 275 32 the the DT cord-329844-w969lczb 275 33 narrative narrative NN cord-329844-w969lczb 275 34 . . . cord-329844-w969lczb 276 1 Several several JJ cord-329844-w969lczb 276 2 kinds kind NNS cord-329844-w969lczb 276 3 of of IN cord-329844-w969lczb 276 4 evidence evidence NN cord-329844-w969lczb 276 5 were be VBD cord-329844-w969lczb 276 6 taken take VBN cord-329844-w969lczb 276 7 into into IN cord-329844-w969lczb 276 8 account account NN cord-329844-w969lczb 276 9 in in IN cord-329844-w969lczb 276 10 development development NN cord-329844-w969lczb 276 11 of of IN cord-329844-w969lczb 276 12 SABR SABR NNP cord-329844-w969lczb 276 13 - - HYPH cord-329844-w969lczb 276 14 P P NNP cord-329844-w969lczb 276 15 , , , cord-329844-w969lczb 276 16 the the DT cord-329844-w969lczb 276 17 Sialic Sialic NNP cord-329844-w969lczb 276 18 Acid Acid NNP cord-329844-w969lczb 276 19 Binding Binding NNP cord-329844-w969lczb 276 20 Region Region NNP cord-329844-w969lczb 276 21 Prediction Prediction NNP cord-329844-w969lczb 276 22 . . . cord-329844-w969lczb 277 1 The the DT cord-329844-w969lczb 277 2 emerging emerge VBG cord-329844-w969lczb 277 3 principles principle NNS cord-329844-w969lczb 277 4 used use VBN cord-329844-w969lczb 277 5 , , , cord-329844-w969lczb 277 6 not not RB cord-329844-w969lczb 277 7 all all DT cord-329844-w969lczb 277 8 of of IN cord-329844-w969lczb 277 9 which which WDT cord-329844-w969lczb 277 10 are be VBP cord-329844-w969lczb 277 11 immediately immediately RB cord-329844-w969lczb 277 12 intuitive intuitive JJ cord-329844-w969lczb 277 13 , , , cord-329844-w969lczb 277 14 are be VBP cord-329844-w969lczb 277 15 argued argue VBN cord-329844-w969lczb 277 16 as as IN cord-329844-w969lczb 277 17 follows follow VBZ cord-329844-w969lczb 277 18 so so IN cord-329844-w969lczb 277 19 that that IN cord-329844-w969lczb 277 20 they -PRON- PRP cord-329844-w969lczb 277 21 may may MD cord-329844-w969lczb 277 22 help help VB cord-329844-w969lczb 277 23 researchers researcher NNS cord-329844-w969lczb 277 24 develop develop VB cord-329844-w969lczb 277 25 improved improve VBN cord-329844-w969lczb 277 26 versions version NNS cord-329844-w969lczb 277 27 . . . cord-329844-w969lczb 278 1 The the DT cord-329844-w969lczb 278 2 method method NN cord-329844-w969lczb 278 3 specifically specifically RB cord-329844-w969lczb 278 4 concerns concern VBZ cord-329844-w969lczb 278 5 predicting predict VBG cord-329844-w969lczb 278 6 regions region NNS cord-329844-w969lczb 278 7 that that WDT cord-329844-w969lczb 278 8 interact interact VBP cord-329844-w969lczb 278 9 with with IN cord-329844-w969lczb 278 10 glycans glycan NNS cord-329844-w969lczb 278 11 containing contain VBG cord-329844-w969lczb 278 12 sialic sialic JJ cord-329844-w969lczb 278 13 acid acid NN cord-329844-w969lczb 278 14 residues residue NNS cord-329844-w969lczb 278 15 . . . cord-329844-w969lczb 279 1 The the DT cord-329844-w969lczb 279 2 development development NN cord-329844-w969lczb 279 3 of of IN cord-329844-w969lczb 279 4 the the DT cord-329844-w969lczb 279 5 method method NN cord-329844-w969lczb 279 6 started start VBD cord-329844-w969lczb 279 7 with with IN cord-329844-w969lczb 279 8 the the DT cord-329844-w969lczb 279 9 qualitative qualitative JJ cord-329844-w969lczb 279 10 sialic sialic NN cord-329844-w969lczb 279 11 acid acid NN cord-329844-w969lczb 279 12 binding bind VBG cord-329844-w969lczb 279 13 region region NN cord-329844-w969lczb 279 14 SABS SABS NNP cord-329844-w969lczb 279 15 score score NN cord-329844-w969lczb 279 16 in in IN cord-329844-w969lczb 279 17 Table Table NNP cord-329844-w969lczb 279 18 1 1 CD cord-329844-w969lczb 279 19 and and CC cord-329844-w969lczb 279 20 used use VBN cord-329844-w969lczb 279 21 in in IN cord-329844-w969lczb 279 22 preliminary preliminary JJ cord-329844-w969lczb 279 23 studies study NNS cord-329844-w969lczb 279 24 above above RB cord-329844-w969lczb 279 25 . . . cord-329844-w969lczb 280 1 Other other JJ cord-329844-w969lczb 280 2 prediction prediction NN cord-329844-w969lczb 280 3 methods method NNS cord-329844-w969lczb 280 4 such such JJ cord-329844-w969lczb 280 5 as as IN cord-329844-w969lczb 280 6 that that DT cord-329844-w969lczb 280 7 discussed discuss VBN cord-329844-w969lczb 280 8 below below IN cord-329844-w969lczb 280 9 also also RB cord-329844-w969lczb 280 10 address address VBP cord-329844-w969lczb 280 11 sugars sugar NNS cord-329844-w969lczb 280 12 or or CC cord-329844-w969lczb 280 13 oligoscharrides oligoscharride VBZ cord-329844-w969lczb 280 14 in in IN cord-329844-w969lczb 280 15 general general JJ cord-329844-w969lczb 280 16 . . . cord-329844-w969lczb 281 1 Recall Recall NNP cord-329844-w969lczb 281 2 , , , cord-329844-w969lczb 281 3 however however RB cord-329844-w969lczb 281 4 , , , cord-329844-w969lczb 281 5 that that IN cord-329844-w969lczb 281 6 even even RB cord-329844-w969lczb 281 7 the the DT cord-329844-w969lczb 281 8 sialic sialic JJ cord-329844-w969lczb 281 9 acid acid NN cord-329844-w969lczb 281 10 components component NNS cord-329844-w969lczb 281 11 comprise comprise VBP cord-329844-w969lczb 281 12 a a DT cord-329844-w969lczb 281 13 fairly fairly RB cord-329844-w969lczb 281 14 diverse diverse JJ cord-329844-w969lczb 281 15 family family NN cord-329844-w969lczb 281 16 of of IN cord-329844-w969lczb 281 17 sugar sugar NN cord-329844-w969lczb 281 18 types type NNS cord-329844-w969lczb 281 19 ( ( -LRB- cord-329844-w969lczb 281 20 see see VB cord-329844-w969lczb 281 21 Introduction Introduction NNP cord-329844-w969lczb 281 22 Section Section NNP cord-329844-w969lczb 281 23 1.3 1.3 CD cord-329844-w969lczb 281 24 ) ) -RRB- cord-329844-w969lczb 281 25 . . . cord-329844-w969lczb 282 1 Also also RB cord-329844-w969lczb 282 2 , , , cord-329844-w969lczb 282 3 while while IN cord-329844-w969lczb 282 4 described describe VBN cord-329844-w969lczb 282 5 as as IN cord-329844-w969lczb 282 6 a a DT cord-329844-w969lczb 282 7 Sialic Sialic NNP cord-329844-w969lczb 282 8 Acid acid NN cord-329844-w969lczb 282 9 Binding Binding NNP cord-329844-w969lczb 282 10 Region Region NNP cord-329844-w969lczb 282 11 Prediction Prediction NNP cord-329844-w969lczb 282 12 , , , cord-329844-w969lczb 282 13 and and CC cord-329844-w969lczb 282 14 this this DT cord-329844-w969lczb 282 15 is be VBZ cord-329844-w969lczb 282 16 believed believe VBN cord-329844-w969lczb 282 17 to to TO cord-329844-w969lczb 282 18 be be VB cord-329844-w969lczb 282 19 the the DT cord-329844-w969lczb 282 20 naturally naturally RB cord-329844-w969lczb 282 21 emerging emerge VBG cord-329844-w969lczb 282 22 emphasis emphasis NN cord-329844-w969lczb 282 23 , , , cord-329844-w969lczb 282 24 it -PRON- PRP cord-329844-w969lczb 282 25 is be VBZ cord-329844-w969lczb 282 26 formally formally RB cord-329844-w969lczb 282 27 the the DT cord-329844-w969lczb 282 28 binding binding NN cord-329844-w969lczb 282 29 to to IN cord-329844-w969lczb 282 30 glycans glycan NNS cord-329844-w969lczb 282 31 that that WDT cord-329844-w969lczb 282 32 contain contain VBP cord-329844-w969lczb 282 33 sialic sialic JJ cord-329844-w969lczb 282 34 acids acid NNS cord-329844-w969lczb 282 35 that that WDT cord-329844-w969lczb 282 36 matters matter VBZ cord-329844-w969lczb 282 37 . . . cord-329844-w969lczb 283 1 ( ( -LRB- cord-329844-w969lczb 283 2 ii ii NN cord-329844-w969lczb 283 3 ) ) -RRB- cord-329844-w969lczb 284 1 The the DT cord-329844-w969lczb 284 2 emphasis emphasis NN cord-329844-w969lczb 284 3 is be VBZ cord-329844-w969lczb 284 4 also also RB cord-329844-w969lczb 284 5 on on IN cord-329844-w969lczb 284 6 binding bind VBG cord-329844-w969lczb 284 7 , , , cord-329844-w969lczb 284 8 not not RB cord-329844-w969lczb 284 9 catalysis catalysis NN cord-329844-w969lczb 284 10 . . . cord-329844-w969lczb 285 1 The the DT cord-329844-w969lczb 285 2 method method NN cord-329844-w969lczb 285 3 is be VBZ cord-329844-w969lczb 285 4 not not RB cord-329844-w969lczb 285 5 specifically specifically RB cord-329844-w969lczb 285 6 concerned concern VBN cord-329844-w969lczb 285 7 with with IN cord-329844-w969lczb 285 8 catalytic catalytic JJ cord-329844-w969lczb 285 9 amino amino NN cord-329844-w969lczb 285 10 acid acid NN cord-329844-w969lczb 285 11 residues residue NNS cord-329844-w969lczb 285 12 involved involve VBN cord-329844-w969lczb 285 13 in in IN cord-329844-w969lczb 285 14 neurominidase neurominidase NNP cord-329844-w969lczb 285 15 action action NNP cord-329844-w969lczb 285 16 ( ( -LRB- cord-329844-w969lczb 285 17 nor nor CC cord-329844-w969lczb 285 18 any any DT cord-329844-w969lczb 285 19 other other JJ cord-329844-w969lczb 285 20 activity activity NN cord-329844-w969lczb 285 21 of of IN cord-329844-w969lczb 285 22 cleaving cleave VBG cord-329844-w969lczb 285 23 modifying modify VBG cord-329844-w969lczb 285 24 the the DT cord-329844-w969lczb 285 25 glycan glycan NN cord-329844-w969lczb 285 26 to to TO cord-329844-w969lczb 285 27 reduce reduce VB cord-329844-w969lczb 285 28 virus virus NN cord-329844-w969lczb 285 29 binding binding NN cord-329844-w969lczb 285 30 , , , cord-329844-w969lczb 285 31 e.g. e.g. IN cord-329844-w969lczb 285 32 esterases esterases NNP cord-329844-w969lczb 285 33 , , , cord-329844-w969lczb 285 34 deacetylases deacetylases NNP cord-329844-w969lczb 285 35 ) ) -RRB- cord-329844-w969lczb 285 36 . . . cord-329844-w969lczb 286 1 While while IN cord-329844-w969lczb 286 2 evidence evidence NN cord-329844-w969lczb 286 3 of of IN cord-329844-w969lczb 286 4 neuraminidase neuraminidase NN cord-329844-w969lczb 286 5 activity activity NN cord-329844-w969lczb 286 6 in in IN cord-329844-w969lczb 286 7 SARS SARS NNP cord-329844-w969lczb 286 8 - - HYPH cord-329844-w969lczb 286 9 CoV-2 CoV-2 NNP cord-329844-w969lczb 286 10 would would MD cord-329844-w969lczb 286 11 be be VB cord-329844-w969lczb 286 12 very very RB cord-329844-w969lczb 286 13 important important JJ cord-329844-w969lczb 286 14 , , , cord-329844-w969lczb 286 15 the the DT cord-329844-w969lczb 286 16 current current JJ cord-329844-w969lczb 286 17 evidence evidence NN cord-329844-w969lczb 286 18 is be VBZ cord-329844-w969lczb 286 19 that that DT cord-329844-w969lczb 286 20 focus focus NN cord-329844-w969lczb 286 21 should should MD cord-329844-w969lczb 286 22 be be VB cord-329844-w969lczb 286 23 on on IN cord-329844-w969lczb 286 24 sialic sialic JJ cord-329844-w969lczb 286 25 acid acid NN cord-329844-w969lczb 286 26 binding binding NN cord-329844-w969lczb 286 27 . . . cord-329844-w969lczb 287 1 This this DT cord-329844-w969lczb 287 2 is be VBZ cord-329844-w969lczb 287 3 because because IN cord-329844-w969lczb 287 4 of of IN cord-329844-w969lczb 287 5 lack lack NN cord-329844-w969lczb 287 6 of of IN cord-329844-w969lczb 287 7 any any DT cord-329844-w969lczb 287 8 strong strong JJ cord-329844-w969lczb 287 9 evidence evidence NN cord-329844-w969lczb 287 10 for for IN cord-329844-w969lczb 287 11 such such JJ cord-329844-w969lczb 287 12 enzymic enzymic NNP cord-329844-w969lczb 287 13 activities activity NNS cord-329844-w969lczb 287 14 at at IN cord-329844-w969lczb 287 15 the the DT cord-329844-w969lczb 287 16 time time NN cord-329844-w969lczb 287 17 of of IN cord-329844-w969lczb 287 18 writing writing NN cord-329844-w969lczb 287 19 , , , cord-329844-w969lczb 287 20 and and CC cord-329844-w969lczb 287 21 also also RB cord-329844-w969lczb 287 22 because because IN cord-329844-w969lczb 287 23 neuraminidase neuraminidase NN cord-329844-w969lczb 287 24 inhibitors inhibitor NNS cord-329844-w969lczb 287 25 approved approve VBN cord-329844-w969lczb 287 26 as as IN cord-329844-w969lczb 287 27 dugs dug NNS cord-329844-w969lczb 287 28 , , , cord-329844-w969lczb 287 29 Oseltamivir Oseltamivir NNP cord-329844-w969lczb 287 30 ( ( -LRB- cord-329844-w969lczb 287 31 Tamiflu Tamiflu NNP cord-329844-w969lczb 287 32 ) ) -RRB- cord-329844-w969lczb 287 33 , , , cord-329844-w969lczb 287 34 and and CC cord-329844-w969lczb 287 35 Zanamivir Zanamivir NNP cord-329844-w969lczb 287 36 ( ( -LRB- cord-329844-w969lczb 287 37 Relenza Relenza NNP cord-329844-w969lczb 287 38 ) ) -RRB- cord-329844-w969lczb 287 39 have have VBP cord-329844-w969lczb 287 40 been be VBN cord-329844-w969lczb 287 41 tested test VBN cord-329844-w969lczb 287 42 on on IN cord-329844-w969lczb 287 43 SARS SARS NNP cord-329844-w969lczb 287 44 - - HYPH cord-329844-w969lczb 287 45 CoV-2 CoV-2 NNP cord-329844-w969lczb 287 46 in in IN cord-329844-w969lczb 287 47 vitro vitro FW cord-329844-w969lczb 287 48 and and CC cord-329844-w969lczb 287 49 were be VBD cord-329844-w969lczb 287 50 not not RB cord-329844-w969lczb 287 51 found find VBN cord-329844-w969lczb 287 52 effective effective JJ cord-329844-w969lczb 287 53 [ [ -LRB- cord-329844-w969lczb 287 54 15 15 CD cord-329844-w969lczb 287 55 ] ] -RRB- cord-329844-w969lczb 287 56 . . . cord-329844-w969lczb 288 1 It -PRON- PRP cord-329844-w969lczb 288 2 is be VBZ cord-329844-w969lczb 288 3 nonetheless nonetheless RB cord-329844-w969lczb 288 4 the the DT cord-329844-w969lczb 288 5 binding binding NN cord-329844-w969lczb 288 6 of of IN cord-329844-w969lczb 288 7 the the DT cord-329844-w969lczb 288 8 appropriate appropriate JJ cord-329844-w969lczb 288 9 glycans glycan NNS cord-329844-w969lczb 288 10 containing contain VBG cord-329844-w969lczb 288 11 sialic sialic JJ cord-329844-w969lczb 288 12 acid acid NN cord-329844-w969lczb 288 13 that that WDT cord-329844-w969lczb 288 14 may may MD cord-329844-w969lczb 288 15 still still RB cord-329844-w969lczb 288 16 be be VB cord-329844-w969lczb 288 17 important important JJ cord-329844-w969lczb 288 18 for for IN cord-329844-w969lczb 288 19 SARS SARS NNP cord-329844-w969lczb 288 20 - - HYPH cord-329844-w969lczb 288 21 CoV CoV NNP cord-329844-w969lczb 288 22 and and CC cord-329844-w969lczb 288 23 SARS SARS NNP cord-329844-w969lczb 288 24 - - HYPH cord-329844-w969lczb 288 25 CoV-2 CoV-2 NNP cord-329844-w969lczb 288 26 infection infection NN cord-329844-w969lczb 288 27 in in IN cord-329844-w969lczb 288 28 vivo vivo NN cord-329844-w969lczb 288 29 , , , cord-329844-w969lczb 288 30 as as IN cord-329844-w969lczb 288 31 it -PRON- PRP cord-329844-w969lczb 288 32 is be VBZ cord-329844-w969lczb 288 33 for for IN cord-329844-w969lczb 288 34 other other JJ cord-329844-w969lczb 288 35 viruses virus NNS cord-329844-w969lczb 288 36 [ [ -LRB- cord-329844-w969lczb 288 37 16 16 CD cord-329844-w969lczb 288 38 ] ] -RRB- cord-329844-w969lczb 288 39 . . . cord-329844-w969lczb 289 1 The the DT cord-329844-w969lczb 289 2 fact fact NN cord-329844-w969lczb 289 3 that that IN cord-329844-w969lczb 289 4 other other JJ cord-329844-w969lczb 289 5 viruses virus NNS cord-329844-w969lczb 289 6 , , , cord-329844-w969lczb 289 7 including include VBG cord-329844-w969lczb 289 8 other other JJ cord-329844-w969lczb 289 9 coronaviruses coronaviruse NNS cord-329844-w969lczb 289 10 , , , cord-329844-w969lczb 289 11 require require VBP cord-329844-w969lczb 289 12 that that DT cord-329844-w969lczb 289 13 function function NN cord-329844-w969lczb 289 14 , , , cord-329844-w969lczb 289 15 followed follow VBN cord-329844-w969lczb 289 16 by by IN cord-329844-w969lczb 289 17 any any DT cord-329844-w969lczb 289 18 demonstration demonstration NN cord-329844-w969lczb 289 19 that that WDT cord-329844-w969lczb 289 20 SARS SARS NNP cord-329844-w969lczb 289 21 - - HYPH cord-329844-w969lczb 289 22 CoV CoV NNP cord-329844-w969lczb 289 23 and and CC cord-329844-w969lczb 289 24 SARS SARS NNP cord-329844-w969lczb 289 25 - - HYPH cord-329844-w969lczb 289 26 CoV-2 CoV-2 NNP cord-329844-w969lczb 289 27 still still RB cord-329844-w969lczb 289 28 possess possess VBP cord-329844-w969lczb 289 29 that that DT cord-329844-w969lczb 289 30 function function NN cord-329844-w969lczb 289 31 , , , cord-329844-w969lczb 289 32 would would MD cord-329844-w969lczb 289 33 suggest suggest VB cord-329844-w969lczb 289 34 that that IN cord-329844-w969lczb 289 35 it -PRON- PRP cord-329844-w969lczb 289 36 could could MD cord-329844-w969lczb 289 37 still still RB cord-329844-w969lczb 289 38 be be VB cord-329844-w969lczb 289 39 a a DT cord-329844-w969lczb 289 40 target target NN cord-329844-w969lczb 289 41 for for IN cord-329844-w969lczb 289 42 pharmaceutical pharmaceutical JJ cord-329844-w969lczb 289 43 drug drug NN cord-329844-w969lczb 289 44 development development NN cord-329844-w969lczb 289 45 , , , cord-329844-w969lczb 289 46 at at IN cord-329844-w969lczb 289 47 least least JJS cord-329844-w969lczb 289 48 as as IN cord-329844-w969lczb 289 49 a a DT cord-329844-w969lczb 289 50 preventative preventative NN cord-329844-w969lczb 289 51 . . . cord-329844-w969lczb 290 1 This this DT cord-329844-w969lczb 290 2 argument argument NN cord-329844-w969lczb 290 3 is be VBZ cord-329844-w969lczb 290 4 not not RB cord-329844-w969lczb 290 5 unique unique JJ cord-329844-w969lczb 290 6 in in IN cord-329844-w969lczb 290 7 its -PRON- PRP$ cord-329844-w969lczb 290 8 general general JJ cord-329844-w969lczb 290 9 form form NN cord-329844-w969lczb 290 10 . . . cord-329844-w969lczb 291 1 For for IN cord-329844-w969lczb 291 2 example example NN cord-329844-w969lczb 291 3 , , , cord-329844-w969lczb 291 4 Fantani Fantani NNP cord-329844-w969lczb 291 5 and and CC cord-329844-w969lczb 291 6 colleagues colleague NNS cord-329844-w969lczb 291 7 believe believe VBP cord-329844-w969lczb 291 8 that that IN cord-329844-w969lczb 291 9 the the DT cord-329844-w969lczb 291 10 SARS SARS NNP cord-329844-w969lczb 291 11 - - HYPH cord-329844-w969lczb 291 12 CoV-2 CoV-2 NNP cord-329844-w969lczb 291 13 also also RB cord-329844-w969lczb 291 14 uses use VBZ cord-329844-w969lczb 291 15 sialic sialic JJ cord-329844-w969lczb 291 16 acids acid NNS cord-329844-w969lczb 291 17 linked link VBN cord-329844-w969lczb 291 18 to to TO cord-329844-w969lczb 291 19 host host VB cord-329844-w969lczb 291 20 cell cell NN cord-329844-w969lczb 291 21 surface surface NN cord-329844-w969lczb 291 22 gangliosides ganglioside NNS cord-329844-w969lczb 291 23 to to TO cord-329844-w969lczb 291 24 somehow somehow RB cord-329844-w969lczb 291 25 facilitate facilitate VB cord-329844-w969lczb 291 26 host host NN cord-329844-w969lczb 291 27 cell cell NN cord-329844-w969lczb 291 28 entry entry NN cord-329844-w969lczb 291 29 and and CC cord-329844-w969lczb 291 30 so so RB cord-329844-w969lczb 291 31 could could MD cord-329844-w969lczb 291 32 represent represent VB cord-329844-w969lczb 291 33 a a DT cord-329844-w969lczb 291 34 therepeutic therepeutic JJ cord-329844-w969lczb 291 35 target target NN cord-329844-w969lczb 291 36 [ [ -LRB- cord-329844-w969lczb 291 37 17 17 CD cord-329844-w969lczb 291 38 ] ] -RRB- cord-329844-w969lczb 291 39 . . . cord-329844-w969lczb 292 1 ( ( -LRB- cord-329844-w969lczb 292 2 iii iii NN cord-329844-w969lczb 292 3 ) ) -RRB- cord-329844-w969lczb 293 1 The the DT cord-329844-w969lczb 293 2 method method NN cord-329844-w969lczb 293 3 seeks seek VBZ cord-329844-w969lczb 293 4 to to TO cord-329844-w969lczb 293 5 predict predict VB cord-329844-w969lczb 293 6 whole whole JJ cord-329844-w969lczb 293 7 domains domain NNS cord-329844-w969lczb 293 8 and and CC cord-329844-w969lczb 293 9 proteins protein NNS cord-329844-w969lczb 293 10 that that WDT cord-329844-w969lczb 293 11 bind bind VBP cord-329844-w969lczb 293 12 sialic sialic NN cord-329844-w969lczb 293 13 acid acid NN cord-329844-w969lczb 293 14 , , , cord-329844-w969lczb 293 15 not not RB cord-329844-w969lczb 293 16 specific specific JJ cord-329844-w969lczb 293 17 short short JJ cord-329844-w969lczb 293 18 sequence sequence NN cord-329844-w969lczb 293 19 motifs motif NNS cord-329844-w969lczb 293 20 . . . cord-329844-w969lczb 294 1 That that DT cord-329844-w969lczb 294 2 is be VBZ cord-329844-w969lczb 294 3 the the DT cord-329844-w969lczb 294 4 case case NN cord-329844-w969lczb 294 5 even even RB cord-329844-w969lczb 294 6 though though IN cord-329844-w969lczb 294 7 the the DT cord-329844-w969lczb 294 8 predictions prediction NNS cord-329844-w969lczb 294 9 assign assign VBP cord-329844-w969lczb 294 10 a a DT cord-329844-w969lczb 294 11 sialic sialic JJ cord-329844-w969lczb 294 12 acid acid NN cord-329844-w969lczb 294 13 binding binding NN cord-329844-w969lczb 294 14 score score NN cord-329844-w969lczb 294 15 to to IN cord-329844-w969lczb 294 16 each each DT cord-329844-w969lczb 294 17 residue residue NN cord-329844-w969lczb 294 18 in in IN cord-329844-w969lczb 294 19 the the DT cord-329844-w969lczb 294 20 domain domain NN cord-329844-w969lczb 294 21 or or CC cord-329844-w969lczb 294 22 protein protein NN cord-329844-w969lczb 294 23 , , , cord-329844-w969lczb 294 24 which which WDT cord-329844-w969lczb 294 25 can can MD cord-329844-w969lczb 294 26 of of IN cord-329844-w969lczb 294 27 course course NN cord-329844-w969lczb 294 28 still still RB cord-329844-w969lczb 294 29 be be VB cord-329844-w969lczb 294 30 inspected inspect VBN cord-329844-w969lczb 294 31 as as IN cord-329844-w969lczb 294 32 of of IN cord-329844-w969lczb 294 33 potential potential JJ cord-329844-w969lczb 294 34 involvement involvement NN cord-329844-w969lczb 294 35 in in IN cord-329844-w969lczb 294 36 direct direct JJ cord-329844-w969lczb 294 37 binding binding NN cord-329844-w969lczb 294 38 . . . cord-329844-w969lczb 295 1 The the DT cord-329844-w969lczb 295 2 threshold threshold NN cord-329844-w969lczb 295 3 and and CC cord-329844-w969lczb 295 4 scale scale NN cord-329844-w969lczb 295 5 of of IN cord-329844-w969lczb 295 6 the the DT cord-329844-w969lczb 295 7 SABR SABR NNP cord-329844-w969lczb 295 8 - - HYPH cord-329844-w969lczb 295 9 P p NN cord-329844-w969lczb 295 10 prediction prediction NN cord-329844-w969lczb 295 11 method method NN cord-329844-w969lczb 295 12 is be VBZ cord-329844-w969lczb 295 13 set set VBN cord-329844-w969lczb 295 14 such such JJ cord-329844-w969lczb 295 15 that that IN cord-329844-w969lczb 295 16 any any DT cord-329844-w969lczb 295 17 residue residue NN cord-329844-w969lczb 295 18 ( ( -LRB- cord-329844-w969lczb 295 19 in in IN cord-329844-w969lczb 295 20 practice practice NN cord-329844-w969lczb 295 21 it -PRON- PRP cord-329844-w969lczb 295 22 is be VBZ cord-329844-w969lczb 295 23 almost almost RB cord-329844-w969lczb 295 24 always always RB cord-329844-w969lczb 295 25 a a DT cord-329844-w969lczb 295 26 continuous continuous JJ cord-329844-w969lczb 295 27 run run NN cord-329844-w969lczb 295 28 of of IN cord-329844-w969lczb 295 29 residues residue NNS cord-329844-w969lczb 295 30 ) ) -RRB- cord-329844-w969lczb 295 31 with with IN cord-329844-w969lczb 295 32 a a DT cord-329844-w969lczb 295 33 sialic sialic JJ cord-329844-w969lczb 295 34 acid acid NN cord-329844-w969lczb 295 35 binding binding NN cord-329844-w969lczb 295 36 score score NN cord-329844-w969lczb 295 37 of of IN cord-329844-w969lczb 295 38 more more JJR cord-329844-w969lczb 295 39 than than IN cord-329844-w969lczb 295 40 100 100 CD cord-329844-w969lczb 295 41 signals signal NNS cord-329844-w969lczb 295 42 that that IN cord-329844-w969lczb 295 43 the the DT cord-329844-w969lczb 295 44 whole whole JJ cord-329844-w969lczb 295 45 domain domain NN cord-329844-w969lczb 295 46 or or CC cord-329844-w969lczb 295 47 protein protein NN cord-329844-w969lczb 295 48 , , , cord-329844-w969lczb 295 49 whichever whichever WDT cord-329844-w969lczb 295 50 was be VBD cord-329844-w969lczb 295 51 provided provide VBN cord-329844-w969lczb 295 52 as as IN cord-329844-w969lczb 295 53 the the DT cord-329844-w969lczb 295 54 whole whole JJ cord-329844-w969lczb 295 55 sequence sequence NN cord-329844-w969lczb 295 56 in in IN cord-329844-w969lczb 295 57 input input NN cord-329844-w969lczb 295 58 , , , cord-329844-w969lczb 295 59 is be VBZ cord-329844-w969lczb 295 60 a a DT cord-329844-w969lczb 295 61 binding binding JJ cord-329844-w969lczb 295 62 module module NN cord-329844-w969lczb 295 63 for for IN cord-329844-w969lczb 295 64 glycans glycan NNS cord-329844-w969lczb 295 65 containing contain VBG cord-329844-w969lczb 295 66 sialic sialic JJ cord-329844-w969lczb 295 67 acid acid NN cord-329844-w969lczb 295 68 . . . cord-329844-w969lczb 296 1 There there EX cord-329844-w969lczb 296 2 are be VBP cord-329844-w969lczb 296 3 several several JJ cord-329844-w969lczb 296 4 reasons reason NNS cord-329844-w969lczb 296 5 for for IN cord-329844-w969lczb 296 6 using use VBG cord-329844-w969lczb 296 7 this this DT cord-329844-w969lczb 296 8 as as IN cord-329844-w969lczb 296 9 a a DT cord-329844-w969lczb 296 10 marker marker NN cord-329844-w969lczb 296 11 of of IN cord-329844-w969lczb 296 12 a a DT cord-329844-w969lczb 296 13 domain domain NN cord-329844-w969lczb 296 14 or or CC cord-329844-w969lczb 296 15 protein protein NN cord-329844-w969lczb 296 16 of of IN cord-329844-w969lczb 296 17 interest interest NN cord-329844-w969lczb 296 18 . . . cord-329844-w969lczb 297 1 One one CD cord-329844-w969lczb 297 2 is be VBZ cord-329844-w969lczb 297 3 that that IN cord-329844-w969lczb 297 4 the the DT cord-329844-w969lczb 297 5 binding binding NN cord-329844-w969lczb 297 6 is be VBZ cord-329844-w969lczb 297 7 to to IN cord-329844-w969lczb 297 8 the the DT cord-329844-w969lczb 297 9 whole whole JJ cord-329844-w969lczb 297 10 glycan glycan NN cord-329844-w969lczb 297 11 as as IN cord-329844-w969lczb 297 12 an an DT cord-329844-w969lczb 297 13 oligosaccharide oligosaccharide NN cord-329844-w969lczb 297 14 or or CC cord-329844-w969lczb 297 15 polysaccharide polysaccharide NN cord-329844-w969lczb 297 16 , , , cord-329844-w969lczb 297 17 not not RB cord-329844-w969lczb 297 18 necessarily necessarily RB cord-329844-w969lczb 297 19 the the DT cord-329844-w969lczb 297 20 sialic sialic JJ cord-329844-w969lczb 297 21 acid acid NN cord-329844-w969lczb 297 22 components component NNS cord-329844-w969lczb 297 23 per per FW cord-329844-w969lczb 297 24 se se FW cord-329844-w969lczb 297 25 , , , cord-329844-w969lczb 297 26 and and CC cord-329844-w969lczb 297 27 therefore therefore RB cord-329844-w969lczb 297 28 the the DT cord-329844-w969lczb 297 29 ligand ligand NN cord-329844-w969lczb 297 30 is be VBZ cord-329844-w969lczb 297 31 a a DT cord-329844-w969lczb 297 32 large large JJ cord-329844-w969lczb 297 33 structure structure NN cord-329844-w969lczb 297 34 that that WDT cord-329844-w969lczb 297 35 could could MD cord-329844-w969lczb 297 36 involve involve VB cord-329844-w969lczb 297 37 several several JJ cord-329844-w969lczb 297 38 binding bind VBG cord-329844-w969lczb 297 39 sites site NNS cord-329844-w969lczb 297 40 . . . cord-329844-w969lczb 298 1 Recall recall VB cord-329844-w969lczb 298 2 that that IN cord-329844-w969lczb 298 3 tryptophan tryptophan NN cord-329844-w969lczb 298 4 was be VBD cord-329844-w969lczb 298 5 found find VBN cord-329844-w969lczb 298 6 to to TO cord-329844-w969lczb 298 7 be be VB cord-329844-w969lczb 298 8 frequently frequently RB cord-329844-w969lczb 298 9 involved involve VBN cord-329844-w969lczb 298 10 in in IN cord-329844-w969lczb 298 11 strong strong JJ cord-329844-w969lczb 298 12 protein protein NN cord-329844-w969lczb 298 13 fold fold VBP cord-329844-w969lczb 298 14 interactions interaction NNS cord-329844-w969lczb 298 15 that that WDT cord-329844-w969lczb 298 16 stabilized stabilize VBD cord-329844-w969lczb 298 17 the the DT cord-329844-w969lczb 298 18 sugar sugar NN cord-329844-w969lczb 298 19 binding bind VBG cord-329844-w969lczb 298 20 domain domain NN cord-329844-w969lczb 298 21 fold fold NN cord-329844-w969lczb 298 22 , , , cord-329844-w969lczb 298 23 yet yet CC cord-329844-w969lczb 298 24 were be VBD cord-329844-w969lczb 298 25 lacking lack VBG cord-329844-w969lczb 298 26 any any DT cord-329844-w969lczb 298 27 direct direct JJ cord-329844-w969lczb 298 28 interactions interaction NNS cord-329844-w969lczb 298 29 with with IN cord-329844-w969lczb 298 30 sugars sugar NNS cord-329844-w969lczb 298 31 and and CC cord-329844-w969lczb 298 32 even even RB cord-329844-w969lczb 298 33 buried bury VBD cord-329844-w969lczb 298 34 [ [ -LRB- cord-329844-w969lczb 298 35 13 13 CD cord-329844-w969lczb 298 36 ] ] -RRB- cord-329844-w969lczb 298 37 . . . cord-329844-w969lczb 299 1 There there EX cord-329844-w969lczb 299 2 are be VBP cord-329844-w969lczb 299 3 at at IN cord-329844-w969lczb 299 4 least least JJS cord-329844-w969lczb 299 5 somewhere somewhere RB cord-329844-w969lczb 299 6 between between IN cord-329844-w969lczb 299 7 10 10 CD cord-329844-w969lczb 299 8 and and CC cord-329844-w969lczb 299 9 100 100 CD cord-329844-w969lczb 299 10 amino amino NN cord-329844-w969lczb 299 11 acid acid NN cord-329844-w969lczb 299 12 residue residue NN cord-329844-w969lczb 299 13 sequence sequence NN cord-329844-w969lczb 299 14 motifs motif NNS cord-329844-w969lczb 299 15 known know VBN cord-329844-w969lczb 299 16 to to TO cord-329844-w969lczb 299 17 be be VB cord-329844-w969lczb 299 18 associated associate VBN cord-329844-w969lczb 299 19 with with IN cord-329844-w969lczb 299 20 sugar sugar NN cord-329844-w969lczb 299 21 binding bind VBG cord-329844-w969lczb 299 22 in in IN cord-329844-w969lczb 299 23 general general JJ cord-329844-w969lczb 299 24 , , , cord-329844-w969lczb 299 25 and and CC cord-329844-w969lczb 299 26 they -PRON- PRP cord-329844-w969lczb 299 27 fall fall VBP cord-329844-w969lczb 299 28 into into IN cord-329844-w969lczb 299 29 some some DT cord-329844-w969lczb 299 30 7 7 CD cord-329844-w969lczb 299 31 fold fold NN cord-329844-w969lczb 299 32 motifs motif NNS cord-329844-w969lczb 299 33 [ [ -LRB- cord-329844-w969lczb 299 34 18 18 CD cord-329844-w969lczb 299 35 ] ] -RRB- cord-329844-w969lczb 299 36 . . . cord-329844-w969lczb 300 1 Also also RB cord-329844-w969lczb 300 2 , , , cord-329844-w969lczb 300 3 as as IN cord-329844-w969lczb 300 4 the the DT cord-329844-w969lczb 300 5 function function NN cord-329844-w969lczb 300 6 of of IN cord-329844-w969lczb 300 7 sialic sialic JJ cord-329844-w969lczb 300 8 acid acid NN cord-329844-w969lczb 300 9 recognition recognition NN cord-329844-w969lczb 300 10 may may MD cord-329844-w969lczb 300 11 be be VB cord-329844-w969lczb 300 12 to to TO cord-329844-w969lczb 300 13 guide guide VB cord-329844-w969lczb 300 14 the the DT cord-329844-w969lczb 300 15 virus virus NN cord-329844-w969lczb 300 16 to to IN cord-329844-w969lczb 300 17 and and CC cord-329844-w969lczb 300 18 across across IN cord-329844-w969lczb 300 19 the the DT cord-329844-w969lczb 300 20 host host NN cord-329844-w969lczb 300 21 cell cell NN cord-329844-w969lczb 300 22 surface surface NN cord-329844-w969lczb 300 23 [ [ -LRB- cord-329844-w969lczb 300 24 17 17 CD cord-329844-w969lczb 300 25 ] ] -RRB- cord-329844-w969lczb 300 26 , , , cord-329844-w969lczb 300 27 sites site NNS cord-329844-w969lczb 300 28 on on IN cord-329844-w969lczb 300 29 the the DT cord-329844-w969lczb 300 30 virus virus NN cord-329844-w969lczb 300 31 that that WDT cord-329844-w969lczb 300 32 enable enable VBP cord-329844-w969lczb 300 33 this this DT cord-329844-w969lczb 300 34 motility motility NN cord-329844-w969lczb 300 35 and and CC cord-329844-w969lczb 300 36 hunt hunt VB cord-329844-w969lczb 300 37 out out RP cord-329844-w969lczb 300 38 points point NNS cord-329844-w969lczb 300 39 for for IN cord-329844-w969lczb 300 40 catalysis catalysis NN cord-329844-w969lczb 300 41 or or CC cord-329844-w969lczb 300 42 simply simply RB cord-329844-w969lczb 300 43 the the DT cord-329844-w969lczb 300 44 strong strong JJ cord-329844-w969lczb 300 45 binding binding NN cord-329844-w969lczb 300 46 appear appear VBP cord-329844-w969lczb 300 47 to to TO cord-329844-w969lczb 300 48 be be VB cord-329844-w969lczb 300 49 as as RB cord-329844-w969lczb 300 50 important important JJ cord-329844-w969lczb 300 51 as as IN cord-329844-w969lczb 300 52 key key JJ cord-329844-w969lczb 300 53 strong strong JJ cord-329844-w969lczb 300 54 binding bind VBG cord-329844-w969lczb 300 55 and and CC cord-329844-w969lczb 300 56 catalytic catalytic JJ cord-329844-w969lczb 300 57 sites site NNS cord-329844-w969lczb 300 58 themselves -PRON- PRP cord-329844-w969lczb 301 1 ( ( -LRB- cord-329844-w969lczb 301 2 e.g. e.g. RB cord-329844-w969lczb 301 3 Ref Ref NNP cord-329844-w969lczb 301 4 [ [ -LRB- cord-329844-w969lczb 301 5 18 18 CD cord-329844-w969lczb 301 6 ] ] -RRB- cord-329844-w969lczb 301 7 ) ) -RRB- cord-329844-w969lczb 301 8 . . . cord-329844-w969lczb 302 1 In in IN cord-329844-w969lczb 302 2 addition addition NN cord-329844-w969lczb 302 3 , , , cord-329844-w969lczb 302 4 predictions prediction NNS cord-329844-w969lczb 302 5 of of IN cord-329844-w969lczb 302 6 localized localized JJ cord-329844-w969lczb 302 7 regions region NNS cord-329844-w969lczb 302 8 of of IN cord-329844-w969lczb 302 9 proteins protein NNS cord-329844-w969lczb 302 10 as as IN cord-329844-w969lczb 302 11 sugar sugar NN cord-329844-w969lczb 302 12 binding binding NN cord-329844-w969lczb 302 13 sites site NNS cord-329844-w969lczb 302 14 are be VBP cord-329844-w969lczb 302 15 naturally naturally RB cord-329844-w969lczb 302 16 not not RB cord-329844-w969lczb 302 17 as as RB cord-329844-w969lczb 302 18 good good JJ cord-329844-w969lczb 302 19 as as IN cord-329844-w969lczb 302 20 those those DT cord-329844-w969lczb 302 21 based base VBN cord-329844-w969lczb 302 22 on on IN cord-329844-w969lczb 302 23 predicting predict VBG cord-329844-w969lczb 302 24 that that IN cord-329844-w969lczb 302 25 a a DT cord-329844-w969lczb 302 26 whole whole JJ cord-329844-w969lczb 302 27 domain domain NN cord-329844-w969lczb 302 28 or or CC cord-329844-w969lczb 302 29 protein protein NN cord-329844-w969lczb 302 30 is be VBZ cord-329844-w969lczb 302 31 involved involve VBN cord-329844-w969lczb 302 32 in in IN cord-329844-w969lczb 302 33 sugar sugar NN cord-329844-w969lczb 302 34 binding binding NN cord-329844-w969lczb 302 35 , , , cord-329844-w969lczb 302 36 but but CC cord-329844-w969lczb 302 37 such such PDT cord-329844-w969lczb 302 38 a a DT cord-329844-w969lczb 302 39 prediction prediction NN cord-329844-w969lczb 302 40 remains remain VBZ cord-329844-w969lczb 302 41 valuable valuable JJ cord-329844-w969lczb 302 42 and and CC cord-329844-w969lczb 302 43 indeed indeed RB cord-329844-w969lczb 302 44 well well RB cord-329844-w969lczb 302 45 suited suited JJ cord-329844-w969lczb 302 46 to to IN cord-329844-w969lczb 302 47 the the DT cord-329844-w969lczb 302 48 present present JJ cord-329844-w969lczb 302 49 study study NN cord-329844-w969lczb 302 50 . . . cord-329844-w969lczb 303 1 In in IN cord-329844-w969lczb 303 2 a a DT cord-329844-w969lczb 303 3 particularly particularly RB cord-329844-w969lczb 303 4 detailed detailed JJ cord-329844-w969lczb 303 5 investigation investigation NN cord-329844-w969lczb 303 6 by by IN cord-329844-w969lczb 303 7 Taroni Taroni NNP cord-329844-w969lczb 303 8 et et FW cord-329844-w969lczb 303 9 al al NNP cord-329844-w969lczb 303 10 . . . cord-329844-w969lczb 304 1 , , , cord-329844-w969lczb 304 2 analysis analysis NN cord-329844-w969lczb 304 3 of of IN cord-329844-w969lczb 304 4 the the DT cord-329844-w969lczb 304 5 characteristic characteristic JJ cord-329844-w969lczb 304 6 properties property NNS cord-329844-w969lczb 304 7 of of IN cord-329844-w969lczb 304 8 sugar sugar NN cord-329844-w969lczb 304 9 binding binding NN cord-329844-w969lczb 304 10 sites site NNS cord-329844-w969lczb 304 11 was be VBD cord-329844-w969lczb 304 12 performed perform VBN cord-329844-w969lczb 304 13 on on IN cord-329844-w969lczb 304 14 a a DT cord-329844-w969lczb 304 15 set set NN cord-329844-w969lczb 304 16 of of IN cord-329844-w969lczb 304 17 19 19 CD cord-329844-w969lczb 304 18 sugar sugar NN cord-329844-w969lczb 304 19 binding bind VBG cord-329844-w969lczb 304 20 proteins protein NNS cord-329844-w969lczb 304 21 [ [ -LRB- cord-329844-w969lczb 304 22 19 19 CD cord-329844-w969lczb 304 23 ] ] -RRB- cord-329844-w969lczb 304 24 . . . cord-329844-w969lczb 305 1 Their -PRON- PRP$ cord-329844-w969lczb 305 2 prediction prediction NN cord-329844-w969lczb 305 3 was be VBD cord-329844-w969lczb 305 4 optimized optimize VBN cord-329844-w969lczb 305 5 on on IN cord-329844-w969lczb 305 6 a a DT cord-329844-w969lczb 305 7 training training NN cord-329844-w969lczb 305 8 set set NN cord-329844-w969lczb 305 9 of of IN cord-329844-w969lczb 305 10 19 19 CD cord-329844-w969lczb 305 11 non non JJ cord-329844-w969lczb 305 12 - - JJ cord-329844-w969lczb 305 13 homologous homologous JJ cord-329844-w969lczb 305 14 carbohydrate carbohydrate NN cord-329844-w969lczb 305 15 binding bind VBG cord-329844-w969lczb 305 16 structures structure NNS cord-329844-w969lczb 305 17 and and CC cord-329844-w969lczb 305 18 tested test VBN cord-329844-w969lczb 305 19 on on IN cord-329844-w969lczb 305 20 a a DT cord-329844-w969lczb 305 21 test test NN cord-329844-w969lczb 305 22 set set VBN cord-329844-w969lczb 305 23 of of IN cord-329844-w969lczb 305 24 40 40 CD cord-329844-w969lczb 305 25 protein protein NN cord-329844-w969lczb 305 26 - - HYPH cord-329844-w969lczb 305 27 carbohydrate carbohydrate NN cord-329844-w969lczb 305 28 complexes complex NNS cord-329844-w969lczb 305 29 . . . cord-329844-w969lczb 306 1 The the DT cord-329844-w969lczb 306 2 thoroughness thoroughness NN cord-329844-w969lczb 306 3 of of IN cord-329844-w969lczb 306 4 that that DT cord-329844-w969lczb 306 5 study study NN cord-329844-w969lczb 306 6 and and CC cord-329844-w969lczb 306 7 the the DT cord-329844-w969lczb 306 8 inclusion inclusion NN cord-329844-w969lczb 306 9 of of IN cord-329844-w969lczb 306 10 many many JJ cord-329844-w969lczb 306 11 kinds kind NNS cord-329844-w969lczb 306 12 of of IN cord-329844-w969lczb 306 13 information information NN cord-329844-w969lczb 306 14 would would MD cord-329844-w969lczb 306 15 make make VB cord-329844-w969lczb 306 16 it -PRON- PRP cord-329844-w969lczb 306 17 a a DT cord-329844-w969lczb 306 18 reasonable reasonable JJ cord-329844-w969lczb 306 19 choice choice NN cord-329844-w969lczb 306 20 of of IN cord-329844-w969lczb 306 21 " " `` cord-329844-w969lczb 306 22 gold gold NN cord-329844-w969lczb 306 23 standard standard NN cord-329844-w969lczb 306 24 " " '' cord-329844-w969lczb 306 25 for for IN cord-329844-w969lczb 306 26 comparison comparison NN cord-329844-w969lczb 306 27 , , , cord-329844-w969lczb 306 28 except except IN cord-329844-w969lczb 306 29 that that IN cord-329844-w969lczb 306 30 the the DT cord-329844-w969lczb 306 31 aims aim NNS cord-329844-w969lczb 306 32 were be VBD cord-329844-w969lczb 306 33 substantially substantially RB cord-329844-w969lczb 306 34 different different JJ cord-329844-w969lczb 306 35 , , , cord-329844-w969lczb 306 36 and and CC cord-329844-w969lczb 306 37 the the DT cord-329844-w969lczb 306 38 overall overall JJ cord-329844-w969lczb 306 39 accuracy accuracy NN cord-329844-w969lczb 306 40 of of IN cord-329844-w969lczb 306 41 prediction prediction NN cord-329844-w969lczb 306 42 achieved achieve VBN cord-329844-w969lczb 306 43 was be VBD cord-329844-w969lczb 306 44 only only RB cord-329844-w969lczb 306 45 65 65 CD cord-329844-w969lczb 306 46 % % NN cord-329844-w969lczb 306 47 . . . cord-329844-w969lczb 307 1 It -PRON- PRP cord-329844-w969lczb 307 2 is be VBZ cord-329844-w969lczb 307 3 true true JJ cord-329844-w969lczb 307 4 nonetheless nonetheless RB cord-329844-w969lczb 307 5 that that IN cord-329844-w969lczb 307 6 results result NNS cord-329844-w969lczb 307 7 were be VBD cord-329844-w969lczb 307 8 very very RB cord-329844-w969lczb 307 9 good good JJ cord-329844-w969lczb 307 10 for for IN cord-329844-w969lczb 307 11 carbohydrate carbohydrate NN cord-329844-w969lczb 307 12 - - HYPH cord-329844-w969lczb 307 13 binding bind VBG cord-329844-w969lczb 307 14 enzymes enzyme NNS cord-329844-w969lczb 307 15 as as IN cord-329844-w969lczb 307 16 opposed oppose VBN cord-329844-w969lczb 307 17 to to IN cord-329844-w969lczb 307 18 lectins lectin NNS cord-329844-w969lczb 307 19 , , , cord-329844-w969lczb 307 20 with with IN cord-329844-w969lczb 307 21 a a DT cord-329844-w969lczb 307 22 rate rate NN cord-329844-w969lczb 307 23 of of IN cord-329844-w969lczb 307 24 success success NN cord-329844-w969lczb 307 25 of of IN cord-329844-w969lczb 307 26 87 87 CD cord-329844-w969lczb 307 27 % % NN cord-329844-w969lczb 307 28 . . . cord-329844-w969lczb 308 1 This this DT cord-329844-w969lczb 308 2 emphasis emphasis NN cord-329844-w969lczb 308 3 on on IN cord-329844-w969lczb 308 4 enzyme enzyme NN cord-329844-w969lczb 308 5 catalytic catalytic JJ cord-329844-w969lczb 308 6 sites site NNS cord-329844-w969lczb 308 7 again again RB cord-329844-w969lczb 308 8 argues argue VBZ cord-329844-w969lczb 308 9 for for IN cord-329844-w969lczb 308 10 avoiding avoid VBG cord-329844-w969lczb 308 11 the the DT cord-329844-w969lczb 308 12 use use NN cord-329844-w969lczb 308 13 of of IN cord-329844-w969lczb 308 14 this this DT cord-329844-w969lczb 308 15 kind kind NN cord-329844-w969lczb 308 16 of of IN cord-329844-w969lczb 308 17 approach approach NN cord-329844-w969lczb 308 18 in in IN cord-329844-w969lczb 308 19 the the DT cord-329844-w969lczb 308 20 present present JJ cord-329844-w969lczb 308 21 paper paper NN cord-329844-w969lczb 308 22 , , , cord-329844-w969lczb 308 23 as as IN cord-329844-w969lczb 308 24 covered cover VBN cord-329844-w969lczb 308 25 by by IN cord-329844-w969lczb 308 26 point point NN cord-329844-w969lczb 308 27 ( ( -LRB- cord-329844-w969lczb 308 28 i i NN cord-329844-w969lczb 308 29 ) ) -RRB- cord-329844-w969lczb 308 30 above above RB cord-329844-w969lczb 308 31 . . . cord-329844-w969lczb 309 1 In in IN cord-329844-w969lczb 309 2 summary summary NN cord-329844-w969lczb 309 3 , , , cord-329844-w969lczb 309 4 it -PRON- PRP cord-329844-w969lczb 309 5 may may MD cord-329844-w969lczb 309 6 be be VB cord-329844-w969lczb 309 7 that that IN cord-329844-w969lczb 309 8 a a DT cord-329844-w969lczb 309 9 large large JJ cord-329844-w969lczb 309 10 domain domain NN cord-329844-w969lczb 309 11 or or CC cord-329844-w969lczb 309 12 protein protein NN cord-329844-w969lczb 309 13 that that WDT cord-329844-w969lczb 309 14 has have VBZ cord-329844-w969lczb 309 15 strong strong JJ cord-329844-w969lczb 309 16 signals signal NNS cord-329844-w969lczb 309 17 for for IN cord-329844-w969lczb 309 18 sialic sialic JJ cord-329844-w969lczb 309 19 acid acid NN cord-329844-w969lczb 309 20 binding binding NN cord-329844-w969lczb 309 21 may may MD cord-329844-w969lczb 309 22 be be VB cord-329844-w969lczb 309 23 indicative indicative JJ cord-329844-w969lczb 309 24 of of IN cord-329844-w969lczb 309 25 a a DT cord-329844-w969lczb 309 26 sialic sialic JJ cord-329844-w969lczb 309 27 acid acid NN cord-329844-w969lczb 309 28 binding binding NN cord-329844-w969lczb 309 29 and/or and/or CC cord-329844-w969lczb 309 30 catalytic catalytic JJ cord-329844-w969lczb 309 31 function function NN cord-329844-w969lczb 309 32 even even RB cord-329844-w969lczb 309 33 if if IN cord-329844-w969lczb 309 34 a a DT cord-329844-w969lczb 309 35 specific specific JJ cord-329844-w969lczb 309 36 short short JJ cord-329844-w969lczb 309 37 subsection subsection NN cord-329844-w969lczb 309 38 of of IN cord-329844-w969lczb 309 39 the the DT cord-329844-w969lczb 309 40 sequence sequence NN cord-329844-w969lczb 309 41 predicted predict VBD cord-329844-w969lczb 309 42 as as IN cord-329844-w969lczb 309 43 binding bind VBG cord-329844-w969lczb 309 44 sialic sialic JJ cord-329844-w969lczb 309 45 acids acid NNS cord-329844-w969lczb 309 46 is be VBZ cord-329844-w969lczb 309 47 not not RB cord-329844-w969lczb 309 48 in in IN cord-329844-w969lczb 309 49 the the DT cord-329844-w969lczb 309 50 position position NN cord-329844-w969lczb 309 51 for for IN cord-329844-w969lczb 309 52 which which WDT cord-329844-w969lczb 309 53 a a DT cord-329844-w969lczb 309 54 strong strong JJ cord-329844-w969lczb 309 55 binding binding NN cord-329844-w969lczb 309 56 or or CC cord-329844-w969lczb 309 57 catalysis catalysis NN cord-329844-w969lczb 309 58 has have VBZ cord-329844-w969lczb 309 59 been be VBN cord-329844-w969lczb 309 60 observed observe VBN cord-329844-w969lczb 309 61 . . . cord-329844-w969lczb 310 1 subsequences subsequence NNS cord-329844-w969lczb 310 2 . . . cord-329844-w969lczb 311 1 Only only RB cord-329844-w969lczb 311 2 the the DT cord-329844-w969lczb 311 3 sequence sequence NN cord-329844-w969lczb 311 4 is be VBZ cord-329844-w969lczb 311 5 considered consider VBN cord-329844-w969lczb 311 6 in in IN cord-329844-w969lczb 311 7 the the DT cord-329844-w969lczb 311 8 method method NN cord-329844-w969lczb 311 9 , , , cord-329844-w969lczb 311 10 not not RB cord-329844-w969lczb 311 11 residues residue NNS cord-329844-w969lczb 311 12 brought bring VBN cord-329844-w969lczb 311 13 together together RB cord-329844-w969lczb 311 14 by by IN cord-329844-w969lczb 311 15 the the DT cord-329844-w969lczb 311 16 folding folding NN cord-329844-w969lczb 311 17 of of IN cord-329844-w969lczb 311 18 the the DT cord-329844-w969lczb 311 19 protein protein NN cord-329844-w969lczb 311 20 in in IN cord-329844-w969lczb 311 21 space space NN cord-329844-w969lczb 311 22 . . . cord-329844-w969lczb 312 1 Most Most JJS cord-329844-w969lczb 312 2 prediction prediction NN cord-329844-w969lczb 312 3 methods method NNS cord-329844-w969lczb 312 4 for for IN cord-329844-w969lczb 312 5 predicting predict VBG cord-329844-w969lczb 312 6 sugar sugar NN cord-329844-w969lczb 312 7 binding binding NN cord-329844-w969lczb 312 8 such such JJ cord-329844-w969lczb 312 9 as as IN cord-329844-w969lczb 312 10 the the DT cord-329844-w969lczb 312 11 example example NN cord-329844-w969lczb 312 12 of of IN cord-329844-w969lczb 312 13 Taroni Taroni NNP cord-329844-w969lczb 312 14 et et FW cord-329844-w969lczb 312 15 al al NNP cord-329844-w969lczb 312 16 . . . cord-329844-w969lczb 313 1 [ [ -LRB- cord-329844-w969lczb 313 2 19 19 CD cord-329844-w969lczb 313 3 ] ] -RRB- cord-329844-w969lczb 313 4 discussed discuss VBN cord-329844-w969lczb 313 5 above above RB cord-329844-w969lczb 313 6 are be VBP cord-329844-w969lczb 313 7 not not RB cord-329844-w969lczb 313 8 based base VBN cord-329844-w969lczb 313 9 on on IN cord-329844-w969lczb 313 10 sequence sequence NN cord-329844-w969lczb 313 11 and and CC cord-329844-w969lczb 313 12 the the DT cord-329844-w969lczb 313 13 sugar sugar NN cord-329844-w969lczb 313 14 - - HYPH cord-329844-w969lczb 313 15 binding bind VBG cord-329844-w969lczb 313 16 propensity propensity NN cord-329844-w969lczb 313 17 of of IN cord-329844-w969lczb 313 18 amino amino JJ cord-329844-w969lczb 313 19 acids acid NNS cord-329844-w969lczb 313 20 in in IN cord-329844-w969lczb 313 21 short short JJ cord-329844-w969lczb 313 22 segments segment NNS cord-329844-w969lczb 313 23 alone alone RB cord-329844-w969lczb 313 24 , , , cord-329844-w969lczb 313 25 but but CC cord-329844-w969lczb 313 26 on on IN cord-329844-w969lczb 313 27 regions region NNS cord-329844-w969lczb 313 28 on on IN cord-329844-w969lczb 313 29 a a DT cord-329844-w969lczb 313 30 protein protein NN cord-329844-w969lczb 313 31 surface surface NN cord-329844-w969lczb 313 32 that that WDT cord-329844-w969lczb 313 33 require require VBP cord-329844-w969lczb 313 34 account account NN cord-329844-w969lczb 313 35 of of IN cord-329844-w969lczb 313 36 3D 3d JJ cord-329844-w969lczb 313 37 structural structural JJ cord-329844-w969lczb 313 38 information information NN cord-329844-w969lczb 313 39 , , , cord-329844-w969lczb 313 40 analogous analogous JJ cord-329844-w969lczb 313 41 to to IN cord-329844-w969lczb 313 42 " " `` cord-329844-w969lczb 313 43 discontinuous discontinuous JJ cord-329844-w969lczb 313 44 " " '' cord-329844-w969lczb 313 45 epitopes epitope NNS cord-329844-w969lczb 313 46 or or CC cord-329844-w969lczb 313 47 " " `` cord-329844-w969lczb 313 48 discontinuous discontinuous JJ cord-329844-w969lczb 313 49 determinants determinant NNS cord-329844-w969lczb 313 50 " " '' cord-329844-w969lczb 313 51 of of IN cord-329844-w969lczb 313 52 a a DT cord-329844-w969lczb 313 53 pathogen pathogen NN cord-329844-w969lczb 313 54 protein protein NN cord-329844-w969lczb 313 55 in in IN cord-329844-w969lczb 313 56 the the DT cord-329844-w969lczb 313 57 study study NN cord-329844-w969lczb 313 58 of of IN cord-329844-w969lczb 313 59 immune immune JJ cord-329844-w969lczb 313 60 response response NN cord-329844-w969lczb 313 61 and and CC cord-329844-w969lczb 313 62 in in IN cord-329844-w969lczb 313 63 synthetic synthetic JJ cord-329844-w969lczb 313 64 vaccine vaccine NN cord-329844-w969lczb 313 65 design design NN cord-329844-w969lczb 313 66 . . . cord-329844-w969lczb 314 1 This this DT cord-329844-w969lczb 314 2 kind kind NN cord-329844-w969lczb 314 3 of of IN cord-329844-w969lczb 314 4 approach approach NN cord-329844-w969lczb 314 5 was be VBD cord-329844-w969lczb 314 6 abandoned abandon VBN cord-329844-w969lczb 314 7 in in IN cord-329844-w969lczb 314 8 the the DT cord-329844-w969lczb 314 9 present present JJ cord-329844-w969lczb 314 10 study study NN cord-329844-w969lczb 314 11 not not RB cord-329844-w969lczb 314 12 just just RB cord-329844-w969lczb 314 13 because because IN cord-329844-w969lczb 314 14 it -PRON- PRP cord-329844-w969lczb 314 15 took take VBD cord-329844-w969lczb 314 16 away away RB cord-329844-w969lczb 314 17 the the DT cord-329844-w969lczb 314 18 emphasis emphasis NN cord-329844-w969lczb 314 19 on on IN cord-329844-w969lczb 314 20 the the DT cord-329844-w969lczb 314 21 binding binding NN cord-329844-w969lczb 314 22 functions function NNS cord-329844-w969lczb 314 23 of of IN cord-329844-w969lczb 314 24 whole whole JJ cord-329844-w969lczb 314 25 domains domain NNS cord-329844-w969lczb 314 26 or or CC cord-329844-w969lczb 314 27 proteins protein NNS cord-329844-w969lczb 315 1 but but CC cord-329844-w969lczb 315 2 most most RBS cord-329844-w969lczb 315 3 importantly importantly RB cord-329844-w969lczb 315 4 because because IN cord-329844-w969lczb 315 5 many many JJ cord-329844-w969lczb 315 6 of of IN cord-329844-w969lczb 315 7 the the DT cord-329844-w969lczb 315 8 sites site NNS cord-329844-w969lczb 315 9 of of IN cord-329844-w969lczb 315 10 particular particular JJ cord-329844-w969lczb 315 11 interest interest NN cord-329844-w969lczb 315 12 are be VBP cord-329844-w969lczb 315 13 in in IN cord-329844-w969lczb 315 14 disordered disordered JJ cord-329844-w969lczb 315 15 regions region NNS cord-329844-w969lczb 315 16 , , , cord-329844-w969lczb 315 17 or or CC cord-329844-w969lczb 315 18 otherwise otherwise RB cord-329844-w969lczb 315 19 invisible invisible JJ cord-329844-w969lczb 315 20 in in IN cord-329844-w969lczb 315 21 the the DT cord-329844-w969lczb 315 22 available available JJ cord-329844-w969lczb 315 23 experimental experimental JJ cord-329844-w969lczb 315 24 3D 3d JJ cord-329844-w969lczb 315 25 structure structure NN cord-329844-w969lczb 315 26 , , , cord-329844-w969lczb 315 27 as as IN cord-329844-w969lczb 315 28 discussed discuss VBN cord-329844-w969lczb 315 29 later later RB cord-329844-w969lczb 315 30 below below RB cord-329844-w969lczb 315 31 . . . cord-329844-w969lczb 316 1 It -PRON- PRP cord-329844-w969lczb 316 2 might may MD cord-329844-w969lczb 316 3 even even RB cord-329844-w969lczb 316 4 be be VB cord-329844-w969lczb 316 5 that that IN cord-329844-w969lczb 316 6 a a DT cord-329844-w969lczb 316 7 degree degree NN cord-329844-w969lczb 316 8 of of IN cord-329844-w969lczb 316 9 disorder disorder NN cord-329844-w969lczb 316 10 is be VBZ cord-329844-w969lczb 316 11 important important JJ cord-329844-w969lczb 316 12 for for IN cord-329844-w969lczb 316 13 binding bind VBG cord-329844-w969lczb 316 14 some some DT cord-329844-w969lczb 316 15 sugars sugar NNS cord-329844-w969lczb 316 16 . . . cord-329844-w969lczb 317 1 Also also RB cord-329844-w969lczb 317 2 and and CC cord-329844-w969lczb 317 3 not not RB cord-329844-w969lczb 317 4 least least JJS cord-329844-w969lczb 317 5 , , , cord-329844-w969lczb 317 6 3D 3d JJ cord-329844-w969lczb 317 7 structural structural JJ cord-329844-w969lczb 317 8 information information NN cord-329844-w969lczb 317 9 is be VBZ cord-329844-w969lczb 317 10 not not RB cord-329844-w969lczb 317 11 always always RB cord-329844-w969lczb 317 12 available available JJ cord-329844-w969lczb 317 13 . . . cord-329844-w969lczb 318 1 ( ( -LRB- cord-329844-w969lczb 318 2 v v LS cord-329844-w969lczb 318 3 ) ) -RRB- cord-329844-w969lczb 318 4 Glycophilicty Glycophilicty NNP cord-329844-w969lczb 318 5 parameters parameter NNS cord-329844-w969lczb 318 6 for for IN cord-329844-w969lczb 318 7 amino amino NN cord-329844-w969lczb 318 8 acid acid NN cord-329844-w969lczb 318 9 residues residue NNS cord-329844-w969lczb 318 10 or or CC cord-329844-w969lczb 318 11 sequence sequence NN cord-329844-w969lczb 318 12 patterns pattern NNS cord-329844-w969lczb 318 13 as as IN cord-329844-w969lczb 318 14 obtained obtain VBN cord-329844-w969lczb 318 15 by by IN cord-329844-w969lczb 318 16 other other JJ cord-329844-w969lczb 318 17 workers worker NNS cord-329844-w969lczb 318 18 were be VBD cord-329844-w969lczb 318 19 not not RB cord-329844-w969lczb 318 20 used use VBN cord-329844-w969lczb 318 21 . . . cord-329844-w969lczb 319 1 This this DT cord-329844-w969lczb 319 2 is be VBZ cord-329844-w969lczb 319 3 particularly particularly RB cord-329844-w969lczb 319 4 because because IN cord-329844-w969lczb 319 5 , , , cord-329844-w969lczb 319 6 the the DT cord-329844-w969lczb 319 7 aims aim NNS cord-329844-w969lczb 319 8 , , , cord-329844-w969lczb 319 9 i.e. i.e. FW cord-329844-w969lczb 319 10 what what WDT cord-329844-w969lczb 319 11 things thing NNS cord-329844-w969lczb 319 12 are be VBP cord-329844-w969lczb 319 13 wanted want VBN cord-329844-w969lczb 319 14 to to TO cord-329844-w969lczb 319 15 be be VB cord-329844-w969lczb 319 16 known know VBN cord-329844-w969lczb 319 17 , , , cord-329844-w969lczb 319 18 are be VBP cord-329844-w969lczb 319 19 usually usually RB cord-329844-w969lczb 319 20 very very RB cord-329844-w969lczb 319 21 different different JJ cord-329844-w969lczb 319 22 in in IN cord-329844-w969lczb 319 23 these these DT cord-329844-w969lczb 319 24 methods method NNS cord-329844-w969lczb 319 25 . . . cord-329844-w969lczb 320 1 Although although IN cord-329844-w969lczb 320 2 Taroni Taroni NNP cord-329844-w969lczb 320 3 et et FW cord-329844-w969lczb 320 4 al al NNP cord-329844-w969lczb 320 5 . . NNP cord-329844-w969lczb 320 6 showed show VBD cord-329844-w969lczb 320 7 that that IN cord-329844-w969lczb 320 8 out out IN cord-329844-w969lczb 320 9 of of IN cord-329844-w969lczb 320 10 6 6 CD cord-329844-w969lczb 320 11 partially partially RB cord-329844-w969lczb 320 12 parameters parameter NNS cord-329844-w969lczb 320 13 partially partially RB cord-329844-w969lczb 320 14 dependent dependent JJ cord-329844-w969lczb 320 15 on on IN cord-329844-w969lczb 320 16 3D 3d JJ cord-329844-w969lczb 320 17 information information NN cord-329844-w969lczb 320 18 the the DT cord-329844-w969lczb 320 19 sugar sugar NN cord-329844-w969lczb 320 20 binding bind VBG cord-329844-w969lczb 320 21 propensities propensity NNS cord-329844-w969lczb 320 22 of of IN cord-329844-w969lczb 320 23 certain certain JJ cord-329844-w969lczb 320 24 amino amino NN cord-329844-w969lczb 320 25 acids acid NNS cord-329844-w969lczb 320 26 was be VBD cord-329844-w969lczb 320 27 prominent prominent JJ cord-329844-w969lczb 320 28 in in IN cord-329844-w969lczb 320 29 having have VBG cord-329844-w969lczb 320 30 discriminatory discriminatory JJ cord-329844-w969lczb 320 31 power power NN cord-329844-w969lczb 320 32 , , , cord-329844-w969lczb 320 33 this this DT cord-329844-w969lczb 320 34 was be VBD cord-329844-w969lczb 320 35 in in IN cord-329844-w969lczb 320 36 regard regard NN cord-329844-w969lczb 320 37 to to IN cord-329844-w969lczb 320 38 the the DT cord-329844-w969lczb 320 39 tendency tendency NN cord-329844-w969lczb 320 40 for for IN cord-329844-w969lczb 320 41 being be VBG cord-329844-w969lczb 320 42 in in IN cord-329844-w969lczb 320 43 putative putative JJ cord-329844-w969lczb 320 44 a a DT cord-329844-w969lczb 320 45 sugar sugar NN cord-329844-w969lczb 320 46 binding bind VBG cord-329844-w969lczb 320 47 patch patch NN cord-329844-w969lczb 320 48 compared compare VBN cord-329844-w969lczb 320 49 with with IN cord-329844-w969lczb 320 50 protein protein NN cord-329844-w969lczb 320 51 surfaces surface NNS cord-329844-w969lczb 320 52 in in IN cord-329844-w969lczb 320 53 general general JJ cord-329844-w969lczb 320 54 ( ( -LRB- cord-329844-w969lczb 320 55 requiring require VBG cord-329844-w969lczb 320 56 ordered order VBN cord-329844-w969lczb 320 57 conformation conformation NN cord-329844-w969lczb 320 58 and and CC cord-329844-w969lczb 320 59 experimental experimental JJ cord-329844-w969lczb 320 60 information information NN cord-329844-w969lczb 320 61 about about IN cord-329844-w969lczb 320 62 it -PRON- PRP cord-329844-w969lczb 320 63 ) ) -RRB- cord-329844-w969lczb 320 64 . . . cord-329844-w969lczb 321 1 At at IN cord-329844-w969lczb 321 2 the the DT cord-329844-w969lczb 321 3 same same JJ cord-329844-w969lczb 321 4 time time NN cord-329844-w969lczb 321 5 , , , cord-329844-w969lczb 321 6 it -PRON- PRP cord-329844-w969lczb 321 7 still still RB cord-329844-w969lczb 321 8 concerns concern VBZ cord-329844-w969lczb 321 9 a a DT cord-329844-w969lczb 321 10 specific specific JJ cord-329844-w969lczb 321 11 region region NN cord-329844-w969lczb 321 12 of of IN cord-329844-w969lczb 321 13 a a DT cord-329844-w969lczb 321 14 kind kind NN cord-329844-w969lczb 321 15 rather rather RB cord-329844-w969lczb 321 16 than than IN cord-329844-w969lczb 321 17 predictions prediction NNS cord-329844-w969lczb 321 18 of of IN cord-329844-w969lczb 321 19 domain domain NN cord-329844-w969lczb 321 20 or or CC cord-329844-w969lczb 321 21 proteins protein NNS cord-329844-w969lczb 321 22 as as IN cord-329844-w969lczb 321 23 sugar sugar NN cord-329844-w969lczb 321 24 binding bind VBG cord-329844-w969lczb 321 25 as as IN cord-329844-w969lczb 321 26 a a DT cord-329844-w969lczb 321 27 whole whole NN cord-329844-w969lczb 321 28 . . . cord-329844-w969lczb 322 1 Perhaps perhaps RB cord-329844-w969lczb 322 2 most most RBS cord-329844-w969lczb 322 3 importantly importantly RB cord-329844-w969lczb 322 4 these these DT cord-329844-w969lczb 322 5 studies study NNS cord-329844-w969lczb 322 6 were be VBD cord-329844-w969lczb 322 7 concerned concern VBN cord-329844-w969lczb 322 8 with with IN cord-329844-w969lczb 322 9 binding bind VBG cord-329844-w969lczb 322 10 sugars sugar NNS cord-329844-w969lczb 322 11 in in IN cord-329844-w969lczb 322 12 general general JJ cord-329844-w969lczb 322 13 ( ( -LRB- cord-329844-w969lczb 322 14 not not RB cord-329844-w969lczb 322 15 specifically specifically RB cord-329844-w969lczb 322 16 sialic sialic JJ cord-329844-w969lczb 322 17 acids acid NNS cord-329844-w969lczb 322 18 ) ) -RRB- cord-329844-w969lczb 322 19 . . . cord-329844-w969lczb 323 1 Not not RB cord-329844-w969lczb 323 2 surprisingly surprisingly RB cord-329844-w969lczb 323 3 , , , cord-329844-w969lczb 323 4 therefore therefore RB cord-329844-w969lczb 323 5 , , , cord-329844-w969lczb 323 6 the the DT cord-329844-w969lczb 323 7 amino amino NN cord-329844-w969lczb 323 8 acid acid NN cord-329844-w969lczb 323 9 residue residue NN cord-329844-w969lczb 323 10 propensities propensity NNS cord-329844-w969lczb 323 11 have have VBP cord-329844-w969lczb 323 12 no no DT cord-329844-w969lczb 323 13 significant significant JJ cord-329844-w969lczb 323 14 overall overall JJ cord-329844-w969lczb 323 15 correlation correlation NN cord-329844-w969lczb 323 16 with with IN cord-329844-w969lczb 323 17 the the DT cord-329844-w969lczb 323 18 propensities propensity NNS cord-329844-w969lczb 323 19 in in IN cord-329844-w969lczb 323 20 Table table NN cord-329844-w969lczb 323 21 1 1 CD cord-329844-w969lczb 323 22 used use VBD cord-329844-w969lczb 323 23 and and CC cord-329844-w969lczb 323 24 developed develop VBN cord-329844-w969lczb 323 25 in in IN cord-329844-w969lczb 323 26 the the DT cord-329844-w969lczb 323 27 present present JJ cord-329844-w969lczb 323 28 paper paper NN cord-329844-w969lczb 323 29 . . . cord-329844-w969lczb 324 1 Notably notably RB cord-329844-w969lczb 324 2 , , , cord-329844-w969lczb 324 3 alanine alanine NN cord-329844-w969lczb 324 4 ( ( -LRB- cord-329844-w969lczb 324 5 A A NNP cord-329844-w969lczb 324 6 ) ) -RRB- cord-329844-w969lczb 324 7 , , , cord-329844-w969lczb 324 8 serine serine NN cord-329844-w969lczb 324 9 ( ( -LRB- cord-329844-w969lczb 324 10 S S NNP cord-329844-w969lczb 324 11 ) ) -RRB- cord-329844-w969lczb 324 12 , , , cord-329844-w969lczb 324 13 threonine threonine NN cord-329844-w969lczb 324 14 ( ( -LRB- cord-329844-w969lczb 324 15 T T NNP cord-329844-w969lczb 324 16 ) ) -RRB- cord-329844-w969lczb 324 17 and and CC cord-329844-w969lczb 324 18 cysteine cysteine NN cord-329844-w969lczb 324 19 ( ( -LRB- cord-329844-w969lczb 324 20 C C NNP cord-329844-w969lczb 324 21 ) ) -RRB- cord-329844-w969lczb 324 22 have have VBP cord-329844-w969lczb 324 23 a a DT cord-329844-w969lczb 324 24 propensity propensity NN cord-329844-w969lczb 324 25 against against IN cord-329844-w969lczb 324 26 sugar sugar NN cord-329844-w969lczb 324 27 binding bind VBG cord-329844-w969lczb 324 28 in in IN cord-329844-w969lczb 324 29 their -PRON- PRP$ cord-329844-w969lczb 324 30 approach approach NN cord-329844-w969lczb 324 31 . . . cord-329844-w969lczb 325 1 There there EX cord-329844-w969lczb 325 2 is be VBZ cord-329844-w969lczb 325 3 nonetheless nonetheless RB cord-329844-w969lczb 325 4 the the DT cord-329844-w969lczb 325 5 significant significant JJ cord-329844-w969lczb 325 6 exception exception NN cord-329844-w969lczb 325 7 that that IN cord-329844-w969lczb 325 8 tryptophan tryptophan NN cord-329844-w969lczb 325 9 ( ( -LRB- cord-329844-w969lczb 325 10 W W NNP cord-329844-w969lczb 325 11 ) ) -RRB- cord-329844-w969lczb 325 12 is be VBZ cord-329844-w969lczb 325 13 the the DT cord-329844-w969lczb 325 14 strongest strong JJS cord-329844-w969lczb 325 15 in in IN cord-329844-w969lczb 325 16 both both CC cord-329844-w969lczb 325 17 that that DT cord-329844-w969lczb 325 18 and and CC cord-329844-w969lczb 325 19 the the DT cord-329844-w969lczb 325 20 present present JJ cord-329844-w969lczb 325 21 study study NN cord-329844-w969lczb 325 22 . . . cord-329844-w969lczb 326 1 ( ( -LRB- cord-329844-w969lczb 326 2 vi vi NNP cord-329844-w969lczb 326 3 ) ) -RRB- cord-329844-w969lczb 327 1 A a DT cord-329844-w969lczb 327 2 simple simple JJ cord-329844-w969lczb 327 3 predictive predictive JJ cord-329844-w969lczb 327 4 model model NN cord-329844-w969lczb 327 5 was be VBD cord-329844-w969lczb 327 6 developed develop VBN cord-329844-w969lczb 327 7 based base VBN cord-329844-w969lczb 327 8 on on IN cord-329844-w969lczb 327 9 optimized optimize VBN cord-329844-w969lczb 327 10 parameters parameter NNS cord-329844-w969lczb 327 11 . . . cord-329844-w969lczb 328 1 If if IN cord-329844-w969lczb 328 2 a a DT cord-329844-w969lczb 328 3 simpler simple JJR cord-329844-w969lczb 328 4 method method NN cord-329844-w969lczb 328 5 works work VBZ cord-329844-w969lczb 328 6 as as RB cord-329844-w969lczb 328 7 well well RB cord-329844-w969lczb 328 8 as as IN cord-329844-w969lczb 328 9 a a DT cord-329844-w969lczb 328 10 more more RBR cord-329844-w969lczb 328 11 rigorous rigorous JJ cord-329844-w969lczb 328 12 approach approach NN cord-329844-w969lczb 328 13 , , , cord-329844-w969lczb 328 14 it -PRON- PRP cord-329844-w969lczb 328 15 can can MD cord-329844-w969lczb 328 16 sometimes sometimes RB cord-329844-w969lczb 328 17 provide provide VB cord-329844-w969lczb 328 18 insight insight NN cord-329844-w969lczb 328 19 and and CC cord-329844-w969lczb 328 20 help help VB cord-329844-w969lczb 328 21 build build VB cord-329844-w969lczb 328 22 even even RB cord-329844-w969lczb 328 23 better well RBR cord-329844-w969lczb 328 24 rigorous rigorous JJ cord-329844-w969lczb 328 25 approaches approach NNS cord-329844-w969lczb 328 26 . . . cord-329844-w969lczb 329 1 The the DT cord-329844-w969lczb 329 2 method method NN cord-329844-w969lczb 329 3 used use VBN cord-329844-w969lczb 329 4 in in IN cord-329844-w969lczb 329 5 the the DT cord-329844-w969lczb 329 6 present present JJ cord-329844-w969lczb 329 7 case case NN cord-329844-w969lczb 329 8 was be VBD cord-329844-w969lczb 329 9 initially initially RB cord-329844-w969lczb 329 10 based base VBN cord-329844-w969lczb 329 11 on on IN cord-329844-w969lczb 329 12 the the DT cord-329844-w969lczb 329 13 GOR GOR NNP cord-329844-w969lczb 329 14 method method NN cord-329844-w969lczb 329 15 [ [ -LRB- cord-329844-w969lczb 329 16 20 20 CD cord-329844-w969lczb 329 17 ] ] -RRB- cord-329844-w969lczb 329 18 for for IN cord-329844-w969lczb 329 19 protein protein NN cord-329844-w969lczb 329 20 secondary secondary JJ cord-329844-w969lczb 329 21 structure structure NN cord-329844-w969lczb 329 22 prediction prediction NN cord-329844-w969lczb 329 23 in in IN cord-329844-w969lczb 329 24 which which WDT cord-329844-w969lczb 329 25 sialic sialic JJ cord-329844-w969lczb 329 26 acid acid NN cord-329844-w969lczb 329 27 glycan glycan NN cord-329844-w969lczb 329 28 binding bind VBG cord-329844-w969lczb 329 29 state state NN cord-329844-w969lczb 329 30 of of IN cord-329844-w969lczb 329 31 residues residue NNS cord-329844-w969lczb 329 32 replaced replace VBD cord-329844-w969lczb 329 33 α α NN cord-329844-w969lczb 329 34 - - HYPH cord-329844-w969lczb 329 35 helix helix NNP cord-329844-w969lczb 329 36 , , , cord-329844-w969lczb 329 37 β β NN cord-329844-w969lczb 329 38 - - HYPH cord-329844-w969lczb 329 39 sheet sheet NN cord-329844-w969lczb 329 40 , , , cord-329844-w969lczb 329 41 and and CC cord-329844-w969lczb 329 42 coil coil NN cord-329844-w969lczb 329 43 ( ( -LRB- cord-329844-w969lczb 329 44 or or CC cord-329844-w969lczb 329 45 loop loop NN cord-329844-w969lczb 329 46 ) ) -RRB- cord-329844-w969lczb 329 47 states state NNS cord-329844-w969lczb 329 48 of of IN cord-329844-w969lczb 329 49 residues residue NNS cord-329844-w969lczb 329 50 . . . cord-329844-w969lczb 330 1 However however RB cord-329844-w969lczb 330 2 , , , cord-329844-w969lczb 330 3 it -PRON- PRP cord-329844-w969lczb 330 4 was be VBD cord-329844-w969lczb 330 5 found find VBN cord-329844-w969lczb 330 6 that that IN cord-329844-w969lczb 330 7 the the DT cord-329844-w969lczb 330 8 results result NNS cord-329844-w969lczb 330 9 were be VBD cord-329844-w969lczb 330 10 essentially essentially RB cord-329844-w969lczb 330 11 reproduced reproduce VBN cord-329844-w969lczb 330 12 by by IN cord-329844-w969lczb 330 13 a a DT cord-329844-w969lczb 330 14 simpler simple JJR cord-329844-w969lczb 330 15 model model NN cord-329844-w969lczb 330 16 . . . cord-329844-w969lczb 331 1 This this DT cord-329844-w969lczb 331 2 is be VBZ cord-329844-w969lczb 331 3 primarily primarily RB cord-329844-w969lczb 331 4 because because IN cord-329844-w969lczb 331 5 the the DT cord-329844-w969lczb 331 6 directional directional JJ cord-329844-w969lczb 331 7 effects effect NNS cord-329844-w969lczb 331 8 ( ( -LRB- cord-329844-w969lczb 331 9 in in IN cord-329844-w969lczb 331 10 terms term NNS cord-329844-w969lczb 331 11 of of IN cord-329844-w969lczb 331 12 N n CD cord-329844-w969lczb 331 13 - - HYPH cord-329844-w969lczb 331 14 terminal terminal JJ cord-329844-w969lczb 331 15 direction direction NN cord-329844-w969lczb 331 16 or or CC cord-329844-w969lczb 331 17 C c NN cord-329844-w969lczb 331 18 - - HYPH cord-329844-w969lczb 331 19 terminal terminal JJ cord-329844-w969lczb 331 20 direction direction NN cord-329844-w969lczb 331 21 along along IN cord-329844-w969lczb 331 22 the the DT cord-329844-w969lczb 331 23 amino amino NN cord-329844-w969lczb 331 24 acid acid NN cord-329844-w969lczb 331 25 residue residue NN cord-329844-w969lczb 331 26 sequence sequence NN cord-329844-w969lczb 331 27 ) ) -RRB- cord-329844-w969lczb 331 28 was be VBD cord-329844-w969lczb 331 29 found find VBN cord-329844-w969lczb 331 30 to to TO cord-329844-w969lczb 331 31 be be VB cord-329844-w969lczb 331 32 equivalent equivalent JJ cord-329844-w969lczb 331 33 ( ( -LRB- cord-329844-w969lczb 331 34 i.e. i.e. FW cord-329844-w969lczb 331 35 , , , cord-329844-w969lczb 331 36 symmetrical symmetrical JJ cord-329844-w969lczb 331 37 ) ) -RRB- cord-329844-w969lczb 331 38 and and CC cord-329844-w969lczb 331 39 to to TO cord-329844-w969lczb 331 40 persist persist VB cord-329844-w969lczb 331 41 for for IN cord-329844-w969lczb 331 42 some some DT cord-329844-w969lczb 331 43 8 8 CD cord-329844-w969lczb 331 44 residues residue NNS cord-329844-w969lczb 331 45 in in IN cord-329844-w969lczb 331 46 both both DT cord-329844-w969lczb 331 47 directions direction NNS cord-329844-w969lczb 331 48 , , , cord-329844-w969lczb 331 49 very very RB cord-329844-w969lczb 331 50 like like IN cord-329844-w969lczb 331 51 the the DT cord-329844-w969lczb 331 52 influence influence NN cord-329844-w969lczb 331 53 of of IN cord-329844-w969lczb 331 54 alanine alanine NN cord-329844-w969lczb 331 55 on on IN cord-329844-w969lczb 331 56 α α NN cord-329844-w969lczb 331 57 - - HYPH cord-329844-w969lczb 331 58 helix helix NN cord-329844-w969lczb 331 59 formation formation NN cord-329844-w969lczb 331 60 in in IN cord-329844-w969lczb 331 61 the the DT cord-329844-w969lczb 331 62 GOR GOR NNP cord-329844-w969lczb 331 63 method method NN cord-329844-w969lczb 331 64 [ [ -LRB- cord-329844-w969lczb 331 65 20 20 CD cord-329844-w969lczb 331 66 ] ] -RRB- cord-329844-w969lczb 331 67 . . . cord-329844-w969lczb 332 1 Consequently consequently RB cord-329844-w969lczb 332 2 the the DT cord-329844-w969lczb 332 3 final final JJ cord-329844-w969lczb 332 4 method method NN cord-329844-w969lczb 332 5 used use VBN cord-329844-w969lczb 332 6 in in IN cord-329844-w969lczb 332 7 the the DT cord-329844-w969lczb 332 8 present present JJ cord-329844-w969lczb 332 9 study study NN cord-329844-w969lczb 332 10 consisted consist VBD cord-329844-w969lczb 332 11 of of IN cord-329844-w969lczb 332 12 just just RB cord-329844-w969lczb 332 13 two two CD cord-329844-w969lczb 332 14 changes change NNS cord-329844-w969lczb 332 15 to to IN cord-329844-w969lczb 332 16 that that DT cord-329844-w969lczb 332 17 used use VBN cord-329844-w969lczb 332 18 in in IN cord-329844-w969lczb 332 19 previous previous JJ cord-329844-w969lczb 332 20 Results result NNS cord-329844-w969lczb 332 21 Section section NN cord-329844-w969lczb 332 22 4.3 4.3 CD cord-329844-w969lczb 332 23 above above RB cord-329844-w969lczb 332 24 , , , cord-329844-w969lczb 332 25 the the DT cord-329844-w969lczb 332 26 second second JJ cord-329844-w969lczb 332 27 being being NN cord-329844-w969lczb 332 28 described describe VBN cord-329844-w969lczb 332 29 in in IN cord-329844-w969lczb 332 30 point point NN cord-329844-w969lczb 332 31 ( ( -LRB- cord-329844-w969lczb 332 32 vii vii NN cord-329844-w969lczb 332 33 ) ) -RRB- cord-329844-w969lczb 332 34 below below RB cord-329844-w969lczb 332 35 . . . cord-329844-w969lczb 333 1 The the DT cord-329844-w969lczb 333 2 qualitative qualitative JJ cord-329844-w969lczb 333 3 scores score NNS cord-329844-w969lczb 333 4 as as IN cord-329844-w969lczb 333 5 parameters parameter NNS cord-329844-w969lczb 333 6 to to IN cord-329844-w969lczb 333 7 types type NNS cord-329844-w969lczb 333 8 of of IN cord-329844-w969lczb 333 9 amino amino NN cord-329844-w969lczb 333 10 acid acid NN cord-329844-w969lczb 333 11 residue residue NN cord-329844-w969lczb 333 12 as as IN cord-329844-w969lczb 333 13 shown show VBN cord-329844-w969lczb 333 14 in in IN cord-329844-w969lczb 333 15 Table Table NNP cord-329844-w969lczb 333 16 1 1 CD cord-329844-w969lczb 333 17 were be VBD cord-329844-w969lczb 333 18 based base VBN cord-329844-w969lczb 333 19 on on IN cord-329844-w969lczb 333 20 visual visual JJ cord-329844-w969lczb 333 21 observations observation NNS cord-329844-w969lczb 333 22 by by IN cord-329844-w969lczb 333 23 the the DT cord-329844-w969lczb 333 24 present present JJ cord-329844-w969lczb 333 25 author author NN cord-329844-w969lczb 333 26 and and CC cord-329844-w969lczb 333 27 a a DT cord-329844-w969lczb 333 28 survey survey NN cord-329844-w969lczb 333 29 of of IN cord-329844-w969lczb 333 30 sites site NNS cord-329844-w969lczb 333 31 in in IN cord-329844-w969lczb 333 32 the the DT cord-329844-w969lczb 333 33 literature literature NN cord-329844-w969lczb 333 34 , , , cord-329844-w969lczb 333 35 and and CC cord-329844-w969lczb 333 36 this this DT cord-329844-w969lczb 333 37 was be VBD cord-329844-w969lczb 333 38 improved improve VBN cord-329844-w969lczb 333 39 by by IN cord-329844-w969lczb 333 40 optimization optimization NN cord-329844-w969lczb 333 41 on on IN cord-329844-w969lczb 333 42 essentially essentially RB cord-329844-w969lczb 333 43 the the DT cord-329844-w969lczb 333 44 same same JJ cord-329844-w969lczb 333 45 set set NN cord-329844-w969lczb 333 46 of of IN cord-329844-w969lczb 333 47 proteins protein NNS cord-329844-w969lczb 333 48 examined examine VBN cord-329844-w969lczb 333 49 . . . cord-329844-w969lczb 334 1 The the DT cord-329844-w969lczb 334 2 20 20 CD cord-329844-w969lczb 334 3 amino amino NN cord-329844-w969lczb 334 4 acids acid NNS cord-329844-w969lczb 334 5 were be VBD cord-329844-w969lczb 334 6 initially initially RB cord-329844-w969lczb 334 7 assigned assign VBN cord-329844-w969lczb 334 8 the the DT cord-329844-w969lczb 334 9 qualitative qualitative JJ cord-329844-w969lczb 334 10 parameters parameter NNS cord-329844-w969lczb 334 11 of of IN cord-329844-w969lczb 334 12 Table table NN cord-329844-w969lczb 334 13 1 1 CD cord-329844-w969lczb 334 14 , , , cord-329844-w969lczb 334 15 then then RB cord-329844-w969lczb 334 16 these these DT cord-329844-w969lczb 334 17 20 20 CD cord-329844-w969lczb 334 18 parameters parameter NNS cord-329844-w969lczb 334 19 were be VBD cord-329844-w969lczb 334 20 optimized optimize VBN cord-329844-w969lczb 334 21 to to TO cord-329844-w969lczb 334 22 optimize optimize VB cord-329844-w969lczb 334 23 sialic sialic JJ cord-329844-w969lczb 334 24 acid acid NN cord-329844-w969lczb 334 25 glycan glycan NN cord-329844-w969lczb 334 26 binding bind VBG cord-329844-w969lczb 334 27 predictions prediction NNS cord-329844-w969lczb 334 28 as as IN cord-329844-w969lczb 334 29 positive positive JJ cord-329844-w969lczb 334 30 for for IN cord-329844-w969lczb 334 31 20 20 CD cord-329844-w969lczb 334 32 sialic sialic JJ cord-329844-w969lczb 334 33 acid acid NN cord-329844-w969lczb 334 34 glycan glycan NN cord-329844-w969lczb 334 35 binding bind VBG cord-329844-w969lczb 334 36 proteins protein NNS cord-329844-w969lczb 334 37 , , , cord-329844-w969lczb 334 38 and and CC cord-329844-w969lczb 334 39 negative negative JJ cord-329844-w969lczb 334 40 for for IN cord-329844-w969lczb 334 41 10 10 CD cord-329844-w969lczb 334 42 proteins protein NNS cord-329844-w969lczb 334 43 not not RB cord-329844-w969lczb 334 44 considered consider VBN cord-329844-w969lczb 334 45 as as IN cord-329844-w969lczb 334 46 binding bind VBG cord-329844-w969lczb 334 47 sugars sugar NNS cord-329844-w969lczb 334 48 , , , cord-329844-w969lczb 334 49 and and CC cord-329844-w969lczb 334 50 10 10 CD cord-329844-w969lczb 334 51 proteins protein NNS cord-329844-w969lczb 334 52 such such JJ cord-329844-w969lczb 334 53 as as IN cord-329844-w969lczb 334 54 lectins lectin NNS cord-329844-w969lczb 334 55 that that WDT cord-329844-w969lczb 334 56 bind bind VBP cord-329844-w969lczb 334 57 other other JJ cord-329844-w969lczb 334 58 sugars sugar NNS cord-329844-w969lczb 334 59 that that WDT cord-329844-w969lczb 334 60 do do VBP cord-329844-w969lczb 334 61 not not RB cord-329844-w969lczb 334 62 contain contain VB cord-329844-w969lczb 334 63 sialic sialic JJ cord-329844-w969lczb 334 64 acids acid NNS cord-329844-w969lczb 334 65 . . . cord-329844-w969lczb 335 1 This this DT cord-329844-w969lczb 335 2 gave give VBD cord-329844-w969lczb 335 3 as as IN cord-329844-w969lczb 335 4 before before IN cord-329844-w969lczb 335 5 glycine glycine NN cord-329844-w969lczb 335 6 ( ( -LRB- cord-329844-w969lczb 335 7 G G NNP cord-329844-w969lczb 335 8 ) ) -RRB- cord-329844-w969lczb 335 9 , , , cord-329844-w969lczb 335 10 alanine alanine NN cord-329844-w969lczb 335 11 ( ( -LRB- cord-329844-w969lczb 335 12 A a NN cord-329844-w969lczb 335 13 ) ) -RRB- cord-329844-w969lczb 335 14 aspartate aspartate NN cord-329844-w969lczb 335 15 ( ( -LRB- cord-329844-w969lczb 335 16 D D NNP cord-329844-w969lczb 335 17 ) ) -RRB- cord-329844-w969lczb 335 18 , , , cord-329844-w969lczb 335 19 asparagine asparagine NN cord-329844-w969lczb 335 20 ( ( -LRB- cord-329844-w969lczb 335 21 N N NNP cord-329844-w969lczb 335 22 ) ) -RRB- cord-329844-w969lczb 335 23 , , , cord-329844-w969lczb 335 24 serine serine NN cord-329844-w969lczb 335 25 ( ( -LRB- cord-329844-w969lczb 335 26 S S NNP cord-329844-w969lczb 335 27 ) ) -RRB- cord-329844-w969lczb 335 28 , , , cord-329844-w969lczb 335 29 threonine threonine NN cord-329844-w969lczb 335 30 ( ( -LRB- cord-329844-w969lczb 335 31 T T NNP cord-329844-w969lczb 335 32 ) ) -RRB- cord-329844-w969lczb 335 33 , , , cord-329844-w969lczb 335 34 cystine cystine NN cord-329844-w969lczb 335 35 / / SYM cord-329844-w969lczb 335 36 cysteine cysteine NN cord-329844-w969lczb 335 37 ( ( -LRB- cord-329844-w969lczb 335 38 C c NN cord-329844-w969lczb 335 39 ) ) -RRB- cord-329844-w969lczb 335 40 each each DT cord-329844-w969lczb 335 41 with with IN cord-329844-w969lczb 335 42 a a DT cord-329844-w969lczb 335 43 score score NN cord-329844-w969lczb 335 44 of of IN cord-329844-w969lczb 335 45 1 1 CD cord-329844-w969lczb 335 46 , , , cord-329844-w969lczb 335 47 and and CC cord-329844-w969lczb 335 48 the the DT cord-329844-w969lczb 335 49 rest rest NN cord-329844-w969lczb 335 50 assigned assign VBN cord-329844-w969lczb 335 51 0 0 CD cord-329844-w969lczb 335 52 , , , cord-329844-w969lczb 335 53 except except IN cord-329844-w969lczb 335 54 for for IN cord-329844-w969lczb 335 55 tyrosine tyrosine NN cord-329844-w969lczb 335 56 ( ( -LRB- cord-329844-w969lczb 335 57 Y Y NNP cord-329844-w969lczb 335 58 phenylalanine phenylalanine NN cord-329844-w969lczb 335 59 ( ( -LRB- cord-329844-w969lczb 335 60 F F NNP cord-329844-w969lczb 335 61 ) ) -RRB- cord-329844-w969lczb 335 62 and and CC cord-329844-w969lczb 335 63 histidine histidine NN cord-329844-w969lczb 335 64 ( ( -LRB- cord-329844-w969lczb 335 65 H h NN cord-329844-w969lczb 335 66 ) ) -RRB- cord-329844-w969lczb 335 67 that that WDT cord-329844-w969lczb 335 68 were be VBD cord-329844-w969lczb 335 69 now now RB cord-329844-w969lczb 335 70 assigned assign VBN cord-329844-w969lczb 335 71 larger large JJR cord-329844-w969lczb 335 72 parameter parameter NN cord-329844-w969lczb 335 73 values value NNS cord-329844-w969lczb 335 74 of of IN cord-329844-w969lczb 335 75 2 2 CD cord-329844-w969lczb 335 76 and and CC cord-329844-w969lczb 335 77 tryptophan tryptophan NN cord-329844-w969lczb 335 78 ( ( -LRB- cord-329844-w969lczb 335 79 W w NN cord-329844-w969lczb 335 80 ) ) -RRB- cord-329844-w969lczb 335 81 that that WDT cord-329844-w969lczb 335 82 was be VBD cord-329844-w969lczb 335 83 assigned assign VBN cord-329844-w969lczb 335 84 a a DT cord-329844-w969lczb 335 85 larger large JJR cord-329844-w969lczb 335 86 parameter parameter NN cord-329844-w969lczb 335 87 value value NN cord-329844-w969lczb 335 88 of of IN cord-329844-w969lczb 335 89 4 4 CD cord-329844-w969lczb 335 90 . . . cord-329844-w969lczb 336 1 ( ( -LRB- cord-329844-w969lczb 336 2 vii vii NN cord-329844-w969lczb 336 3 ) ) -RRB- cord-329844-w969lczb 336 4 Parameters parameter NNS cord-329844-w969lczb 336 5 describing describe VBG cord-329844-w969lczb 336 6 directional directional JJ cord-329844-w969lczb 336 7 influences influence NNS cord-329844-w969lczb 336 8 of of IN cord-329844-w969lczb 336 9 amino amino NN cord-329844-w969lczb 336 10 acid acid NN cord-329844-w969lczb 336 11 residues residue NNS cord-329844-w969lczb 336 12 were be VBD cord-329844-w969lczb 336 13 modeled model VBN cord-329844-w969lczb 336 14 in in IN cord-329844-w969lczb 336 15 a a DT cord-329844-w969lczb 336 16 simple simple JJ cord-329844-w969lczb 336 17 way way NN cord-329844-w969lczb 336 18 . . . cord-329844-w969lczb 337 1 In in IN cord-329844-w969lczb 337 2 part part NN cord-329844-w969lczb 337 3 this this DT cord-329844-w969lczb 337 4 is be VBZ cord-329844-w969lczb 337 5 a a DT cord-329844-w969lczb 337 6 response response NN cord-329844-w969lczb 337 7 to to IN cord-329844-w969lczb 337 8 the the DT cord-329844-w969lczb 337 9 above above JJ cord-329844-w969lczb 337 10 point point NN cord-329844-w969lczb 337 11 that that IN cord-329844-w969lczb 337 12 the the DT cord-329844-w969lczb 337 13 directional directional JJ cord-329844-w969lczb 337 14 effects effect NNS cord-329844-w969lczb 337 15 ( ( -LRB- cord-329844-w969lczb 337 16 in in IN cord-329844-w969lczb 337 17 terms term NNS cord-329844-w969lczb 337 18 of of IN cord-329844-w969lczb 337 19 N n CD cord-329844-w969lczb 337 20 - - HYPH cord-329844-w969lczb 337 21 terminal terminal JJ cord-329844-w969lczb 337 22 direction direction NN cord-329844-w969lczb 337 23 or or CC cord-329844-w969lczb 337 24 C c NN cord-329844-w969lczb 337 25 - - HYPH cord-329844-w969lczb 337 26 terminal terminal JJ cord-329844-w969lczb 337 27 direction direction NN cord-329844-w969lczb 337 28 along along IN cord-329844-w969lczb 337 29 the the DT cord-329844-w969lczb 337 30 amino amino NN cord-329844-w969lczb 337 31 acid acid NN cord-329844-w969lczb 337 32 residue residue NN cord-329844-w969lczb 337 33 sequence sequence NN cord-329844-w969lczb 337 34 ) ) -RRB- cord-329844-w969lczb 337 35 are be VBP cord-329844-w969lczb 337 36 symmetrical symmetrical JJ cord-329844-w969lczb 337 37 , , , cord-329844-w969lczb 337 38 but but CC cord-329844-w969lczb 337 39 more more JJR cord-329844-w969lczb 337 40 specifically specifically RB cord-329844-w969lczb 337 41 the the DT cord-329844-w969lczb 337 42 essential essential JJ cord-329844-w969lczb 337 43 features feature NNS cord-329844-w969lczb 337 44 of of IN cord-329844-w969lczb 337 45 the the DT cord-329844-w969lczb 337 46 interactions interaction NNS cord-329844-w969lczb 337 47 between between IN cord-329844-w969lczb 337 48 neighboring neighboring NN cord-329844-w969lczb 337 49 residues residue NNS cord-329844-w969lczb 337 50 can can MD cord-329844-w969lczb 337 51 be be VB cord-329844-w969lczb 337 52 deduced deduce VBN cord-329844-w969lczb 337 53 from from IN cord-329844-w969lczb 337 54 parameters parameter NNS cord-329844-w969lczb 337 55 like like IN cord-329844-w969lczb 337 56 those those DT cord-329844-w969lczb 337 57 in in IN cord-329844-w969lczb 337 58 Table Table NNP cord-329844-w969lczb 337 59 1 1 CD cord-329844-w969lczb 337 60 in in IN cord-329844-w969lczb 337 61 much much RB cord-329844-w969lczb 337 62 the the DT cord-329844-w969lczb 337 63 same same JJ cord-329844-w969lczb 337 64 way way NN cord-329844-w969lczb 337 65 as as IN cord-329844-w969lczb 337 66 the the DT cord-329844-w969lczb 337 67 shape shape NN cord-329844-w969lczb 337 68 of of IN cord-329844-w969lczb 337 69 an an DT cord-329844-w969lczb 337 70 equilateral equilateral JJ cord-329844-w969lczb 337 71 triangle triangle NN cord-329844-w969lczb 337 72 standing stand VBG cord-329844-w969lczb 337 73 on on IN cord-329844-w969lczb 337 74 its -PRON- PRP$ cord-329844-w969lczb 337 75 base base NN cord-329844-w969lczb 337 76 can can MD cord-329844-w969lczb 337 77 be be VB cord-329844-w969lczb 337 78 deduced deduce VBN cord-329844-w969lczb 337 79 from from IN cord-329844-w969lczb 337 80 its -PRON- PRP$ cord-329844-w969lczb 337 81 height height NN cord-329844-w969lczb 337 82 . . . cord-329844-w969lczb 338 1 As as RB cord-329844-w969lczb 338 2 well well RB cord-329844-w969lczb 338 3 as as IN cord-329844-w969lczb 338 4 using use VBG cord-329844-w969lczb 338 5 new new JJ cord-329844-w969lczb 338 6 parameters parameter NNS cord-329844-w969lczb 338 7 , , , cord-329844-w969lczb 338 8 the the DT cord-329844-w969lczb 338 9 initial initial JJ cord-329844-w969lczb 338 10 score score NN cord-329844-w969lczb 338 11 for for IN cord-329844-w969lczb 338 12 a a DT cord-329844-w969lczb 338 13 particular particular JJ cord-329844-w969lczb 338 14 residue residue NN cord-329844-w969lczb 338 15 was be VBD cord-329844-w969lczb 338 16 computed compute VBN cord-329844-w969lczb 338 17 in in IN cord-329844-w969lczb 338 18 the the DT cord-329844-w969lczb 338 19 same same JJ cord-329844-w969lczb 338 20 way way NN cord-329844-w969lczb 338 21 as as IN cord-329844-w969lczb 338 22 that that DT cord-329844-w969lczb 338 23 for for IN cord-329844-w969lczb 338 24 the the DT cord-329844-w969lczb 338 25 whole whole JJ cord-329844-w969lczb 338 26 segment segment NN cord-329844-w969lczb 338 27 of of IN cord-329844-w969lczb 338 28 17 17 CD cord-329844-w969lczb 338 29 residues residue NNS cord-329844-w969lczb 338 30 in in IN cord-329844-w969lczb 338 31 Section section NN cord-329844-w969lczb 338 32 4.3 4.3 CD cord-329844-w969lczb 338 33 , , , cord-329844-w969lczb 338 34 but but CC cord-329844-w969lczb 338 35 was be VBD cord-329844-w969lczb 338 36 specifically specifically RB cord-329844-w969lczb 338 37 considered consider VBN cord-329844-w969lczb 338 38 as as IN cord-329844-w969lczb 338 39 associated associate VBN cord-329844-w969lczb 338 40 with with IN cord-329844-w969lczb 338 41 the the DT cord-329844-w969lczb 338 42 central central JJ cord-329844-w969lczb 338 43 residue residue NN cord-329844-w969lczb 338 44 , , , cord-329844-w969lczb 338 45 and and CC cord-329844-w969lczb 338 46 the the DT cord-329844-w969lczb 338 47 sum sum NN cord-329844-w969lczb 338 48 was be VBD cord-329844-w969lczb 338 49 retained retain VBN cord-329844-w969lczb 338 50 as as IN cord-329844-w969lczb 338 51 that that DT cord-329844-w969lczb 338 52 sum sum NN cord-329844-w969lczb 338 53 rather rather RB cord-329844-w969lczb 338 54 than than IN cord-329844-w969lczb 338 55 the the DT cord-329844-w969lczb 338 56 overall overall JJ cord-329844-w969lczb 338 57 score score NN cord-329844-w969lczb 338 58 being be VBG cord-329844-w969lczb 338 59 averaged average VBN cord-329844-w969lczb 338 60 by by IN cord-329844-w969lczb 338 61 the the DT cord-329844-w969lczb 338 62 number number NN cord-329844-w969lczb 338 63 of of IN cord-329844-w969lczb 338 64 residues residue NNS cord-329844-w969lczb 338 65 in in IN cord-329844-w969lczb 338 66 the the DT cord-329844-w969lczb 338 67 segment segment NN cord-329844-w969lczb 338 68 . . . cord-329844-w969lczb 339 1 Deletions deletion NNS cord-329844-w969lczb 339 2 to to TO cord-329844-w969lczb 339 3 consider consider VB cord-329844-w969lczb 339 4 alignments alignment NNS cord-329844-w969lczb 339 5 of of IN cord-329844-w969lczb 339 6 segments segment NNS cord-329844-w969lczb 339 7 were be VBD cord-329844-w969lczb 339 8 not not RB cord-329844-w969lczb 339 9 applied apply VBN cord-329844-w969lczb 339 10 in in IN cord-329844-w969lczb 339 11 the the DT cord-329844-w969lczb 339 12 SABR SABR NNP cord-329844-w969lczb 339 13 - - HYPH cord-329844-w969lczb 339 14 P p NN cord-329844-w969lczb 339 15 method method NN cord-329844-w969lczb 339 16 . . . cord-329844-w969lczb 340 1 The the DT cord-329844-w969lczb 340 2 above above JJ cord-329844-w969lczb 340 3 sum sum NN cord-329844-w969lczb 340 4 associated associate VBN cord-329844-w969lczb 340 5 with with IN cord-329844-w969lczb 340 6 each each DT cord-329844-w969lczb 340 7 central central JJ cord-329844-w969lczb 340 8 , , , cord-329844-w969lczb 340 9 i.e. i.e. FW cord-329844-w969lczb 340 10 9 9 CD cord-329844-w969lczb 340 11 th th XX cord-329844-w969lczb 340 12 , , , cord-329844-w969lczb 340 13 residue residue NN cord-329844-w969lczb 340 14 , , , cord-329844-w969lczb 340 15 was be VBD cord-329844-w969lczb 340 16 then then RB cord-329844-w969lczb 340 17 averaged average VBN cord-329844-w969lczb 340 18 over over IN cord-329844-w969lczb 340 19 the the DT cord-329844-w969lczb 340 20 corresponding correspond VBG cord-329844-w969lczb 340 21 sums sum NNS cord-329844-w969lczb 340 22 from from IN cord-329844-w969lczb 340 23 the the DT cord-329844-w969lczb 340 24 residues residue NNS cord-329844-w969lczb 340 25 up up RP cord-329844-w969lczb 340 26 to to TO cord-329844-w969lczb 340 27 8 8 CD cord-329844-w969lczb 340 28 away away RB cord-329844-w969lczb 340 29 on on IN cord-329844-w969lczb 340 30 the the DT cord-329844-w969lczb 340 31 N n CD cord-329844-w969lczb 340 32 - - HYPH cord-329844-w969lczb 340 33 terminal terminal JJ cord-329844-w969lczb 340 34 direction direction NN cord-329844-w969lczb 340 35 up up IN cord-329844-w969lczb 340 36 to to TO cord-329844-w969lczb 340 37 8 8 CD cord-329844-w969lczb 340 38 residues residue NNS cord-329844-w969lczb 340 39 in in IN cord-329844-w969lczb 340 40 the the DT cord-329844-w969lczb 340 41 C c NN cord-329844-w969lczb 340 42 - - HYPH cord-329844-w969lczb 340 43 terminal terminal NN cord-329844-w969lczb 340 44 direction direction NN cord-329844-w969lczb 340 45 including include VBG cord-329844-w969lczb 340 46 the the DT cord-329844-w969lczb 340 47 central central JJ cord-329844-w969lczb 340 48 residue residue NN cord-329844-w969lczb 340 49 being be VBG cord-329844-w969lczb 340 50 addressed address VBN cord-329844-w969lczb 340 51 . . . cord-329844-w969lczb 341 1 This this DT cord-329844-w969lczb 341 2 was be VBD cord-329844-w969lczb 341 3 done do VBN cord-329844-w969lczb 341 4 for for IN cord-329844-w969lczb 341 5 every every DT cord-329844-w969lczb 341 6 residue residue NN cord-329844-w969lczb 341 7 in in IN cord-329844-w969lczb 341 8 the the DT cord-329844-w969lczb 341 9 input input NN cord-329844-w969lczb 341 10 sequence sequence NN cord-329844-w969lczb 341 11 . . . cord-329844-w969lczb 342 1 It -PRON- PRP cord-329844-w969lczb 342 2 formally formally RB cord-329844-w969lczb 342 3 models model VBZ cord-329844-w969lczb 342 4 parameters parameter NNS cord-329844-w969lczb 342 5 describing describe VBG cord-329844-w969lczb 342 6 the the DT cord-329844-w969lczb 342 7 directional directional JJ cord-329844-w969lczb 342 8 characteristics characteristic NNS cord-329844-w969lczb 342 9 of of IN cord-329844-w969lczb 342 10 different different JJ cord-329844-w969lczb 342 11 types type NNS cord-329844-w969lczb 342 12 of of IN cord-329844-w969lczb 342 13 amino amino NN cord-329844-w969lczb 342 14 acid acid NN cord-329844-w969lczb 342 15 residue residue NN cord-329844-w969lczb 342 16 , , , cord-329844-w969lczb 342 17 albeit albeit IN cord-329844-w969lczb 342 18 in in IN cord-329844-w969lczb 342 19 a a DT cord-329844-w969lczb 342 20 highly highly RB cord-329844-w969lczb 342 21 empirical empirical JJ cord-329844-w969lczb 342 22 way way NN cord-329844-w969lczb 342 23 . . . cord-329844-w969lczb 343 1 However however RB cord-329844-w969lczb 343 2 , , , cord-329844-w969lczb 343 3 it -PRON- PRP cord-329844-w969lczb 343 4 is be VBZ cord-329844-w969lczb 343 5 simply simply RB cord-329844-w969lczb 343 6 analogous analogous JJ cord-329844-w969lczb 343 7 to to IN cord-329844-w969lczb 343 8 a a DT cord-329844-w969lczb 343 9 smoothing smoothing NN cord-329844-w969lczb 343 10 of of IN cord-329844-w969lczb 343 11 the the DT cord-329844-w969lczb 343 12 propensity propensity NN cord-329844-w969lczb 343 13 plot plot NN cord-329844-w969lczb 343 14 for for IN cord-329844-w969lczb 343 15 residues residue NNS cord-329844-w969lczb 343 16 along along IN cord-329844-w969lczb 343 17 the the DT cord-329844-w969lczb 343 18 overall overall JJ cord-329844-w969lczb 343 19 input input NN cord-329844-w969lczb 343 20 sequence sequence NN cord-329844-w969lczb 343 21 . . . cord-329844-w969lczb 344 1 ( ( -LRB- cord-329844-w969lczb 344 2 viii viii NNP cord-329844-w969lczb 344 3 ) ) -RRB- cord-329844-w969lczb 344 4 Plot Plot NNP cord-329844-w969lczb 344 5 scaling scaling NN cord-329844-w969lczb 344 6 was be VBD cord-329844-w969lczb 344 7 applied apply VBN cord-329844-w969lczb 344 8 to to TO cord-329844-w969lczb 344 9 produce produce VB cord-329844-w969lczb 344 10 a a DT cord-329844-w969lczb 344 11 convenient convenient JJ cord-329844-w969lczb 344 12 decision decision NN cord-329844-w969lczb 344 13 threshold threshold NN cord-329844-w969lczb 344 14 . . . cord-329844-w969lczb 345 1 An an DT cord-329844-w969lczb 345 2 appropriate appropriate JJ cord-329844-w969lczb 345 3 height height NN cord-329844-w969lczb 345 4 scale scale NN cord-329844-w969lczb 345 5 of of IN cord-329844-w969lczb 345 6 the the DT cord-329844-w969lczb 345 7 plot plot NN cord-329844-w969lczb 345 8 , , , cord-329844-w969lczb 345 9 in in IN cord-329844-w969lczb 345 10 which which WDT cord-329844-w969lczb 345 11 a a DT cord-329844-w969lczb 345 12 residue residue NN cord-329844-w969lczb 345 13 with with IN cord-329844-w969lczb 345 14 a a DT cord-329844-w969lczb 345 15 score score NN cord-329844-w969lczb 345 16 of of IN cord-329844-w969lczb 345 17 over over IN cord-329844-w969lczb 345 18 100 100 CD cord-329844-w969lczb 345 19 would would MD cord-329844-w969lczb 345 20 be be VB cord-329844-w969lczb 345 21 considered consider VBN cord-329844-w969lczb 345 22 as as IN cord-329844-w969lczb 345 23 the the DT cord-329844-w969lczb 345 24 whole whole JJ cord-329844-w969lczb 345 25 input input NN cord-329844-w969lczb 345 26 sequence sequence NN cord-329844-w969lczb 345 27 indicative indicative JJ cord-329844-w969lczb 345 28 of of IN cord-329844-w969lczb 345 29 a a DT cord-329844-w969lczb 345 30 sialic sialic JJ cord-329844-w969lczb 345 31 acid acid NN cord-329844-w969lczb 345 32 residue residue NN cord-329844-w969lczb 345 33 binding bind VBG cord-329844-w969lczb 345 34 domain domain NN cord-329844-w969lczb 345 35 or or CC cord-329844-w969lczb 345 36 protein protein NN cord-329844-w969lczb 345 37 , , , cord-329844-w969lczb 345 38 was be VBD cord-329844-w969lczb 345 39 obtained obtain VBN cord-329844-w969lczb 345 40 by by IN cord-329844-w969lczb 345 41 an an DT cord-329844-w969lczb 345 42 empirical empirical JJ cord-329844-w969lczb 345 43 pseudo pseudo JJ cord-329844-w969lczb 345 44 - - JJ cord-329844-w969lczb 345 45 normalization normalization NN cord-329844-w969lczb 345 46 consisting consist VBG cord-329844-w969lczb 345 47 of of IN cord-329844-w969lczb 345 48 dividing divide VBG cord-329844-w969lczb 345 49 each each DT cord-329844-w969lczb 345 50 residue residue NN cord-329844-w969lczb 345 51 score score NN cord-329844-w969lczb 345 52 by by IN cord-329844-w969lczb 345 53 300 300 CD cord-329844-w969lczb 345 54 . . . cord-329844-w969lczb 346 1 Whenever whenever WRB cord-329844-w969lczb 346 2 the the DT cord-329844-w969lczb 346 3 final final JJ cord-329844-w969lczb 346 4 results result NNS cord-329844-w969lczb 346 5 by by IN cord-329844-w969lczb 346 6 SABR SABR NNP cord-329844-w969lczb 346 7 - - HYPH cord-329844-w969lczb 346 8 P P NNP cord-329844-w969lczb 346 9 are be VBP cord-329844-w969lczb 346 10 expressed express VBN cord-329844-w969lczb 346 11 as as IN cord-329844-w969lczb 346 12 a a DT cord-329844-w969lczb 346 13 percentage percentage NN cord-329844-w969lczb 346 14 - - HYPH cord-329844-w969lczb 346 15 like like JJ cord-329844-w969lczb 346 16 score score NN cord-329844-w969lczb 346 17 by by IN cord-329844-w969lczb 346 18 multiplying multiply VBG cord-329844-w969lczb 346 19 all all DT cord-329844-w969lczb 346 20 residue residue NN cord-329844-w969lczb 346 21 scores score NNS cord-329844-w969lczb 346 22 on on IN cord-329844-w969lczb 346 23 the the DT cord-329844-w969lczb 346 24 plot plot NN cord-329844-w969lczb 346 25 by by IN cord-329844-w969lczb 346 26 100 100 CD cord-329844-w969lczb 346 27 , , , cord-329844-w969lczb 346 28 this this DT cord-329844-w969lczb 346 29 is be VBZ cord-329844-w969lczb 346 30 of of IN cord-329844-w969lczb 346 31 course course NN cord-329844-w969lczb 346 32 equivalent equivalent JJ cord-329844-w969lczb 346 33 to to IN cord-329844-w969lczb 346 34 dividing divide VBG cord-329844-w969lczb 346 35 by by IN cord-329844-w969lczb 346 36 3 3 CD cord-329844-w969lczb 346 37 . . . cord-329844-w969lczb 347 1 On on IN cord-329844-w969lczb 347 2 that that DT cord-329844-w969lczb 347 3 percentage percentage NN cord-329844-w969lczb 347 4 basis basis NN cord-329844-w969lczb 347 5 , , , cord-329844-w969lczb 347 6 there there EX cord-329844-w969lczb 347 7 seems seem VBZ cord-329844-w969lczb 347 8 no no DT cord-329844-w969lczb 347 9 benefit benefit NN cord-329844-w969lczb 347 10 it -PRON- PRP cord-329844-w969lczb 347 11 describing describe VBG cord-329844-w969lczb 347 12 scores score NNS cord-329844-w969lczb 347 13 more more RBR cord-329844-w969lczb 347 14 accurately accurately RB cord-329844-w969lczb 347 15 than than IN cord-329844-w969lczb 347 16 to to IN cord-329844-w969lczb 347 17 the the DT cord-329844-w969lczb 347 18 nearest near JJS cord-329844-w969lczb 347 19 integer integer NN cord-329844-w969lczb 347 20 . . . cord-329844-w969lczb 348 1 In in IN cord-329844-w969lczb 348 2 summary summary NN cord-329844-w969lczb 348 3 , , , cord-329844-w969lczb 348 4 the the DT cord-329844-w969lczb 348 5 essential essential JJ cord-329844-w969lczb 348 6 features feature NNS cord-329844-w969lczb 348 7 of of IN cord-329844-w969lczb 348 8 the the DT cord-329844-w969lczb 348 9 simple simple JJ cord-329844-w969lczb 348 10 resulting result VBG cord-329844-w969lczb 348 11 algorithm algorithm NN cord-329844-w969lczb 348 12 are be VBP cord-329844-w969lczb 348 13 as as IN cord-329844-w969lczb 348 14 follows follow VBZ cord-329844-w969lczb 348 15 . . . cord-329844-w969lczb 349 1 ( ( -LRB- cord-329844-w969lczb 349 2 1 1 LS cord-329844-w969lczb 349 3 ) ) -RRB- cord-329844-w969lczb 349 4 Residue Residue NNP cord-329844-w969lczb 349 5 Binding Binding NNP cord-329844-w969lczb 349 6 Parameter Parameter NNP cord-329844-w969lczb 349 7 Assignment Assignment NNP cord-329844-w969lczb 349 8 . . . cord-329844-w969lczb 350 1 Examine examine VB cord-329844-w969lczb 350 2 every every DT cord-329844-w969lczb 350 3 residue residue NN cord-329844-w969lczb 350 4 in in IN cord-329844-w969lczb 350 5 the the DT cord-329844-w969lczb 350 6 sequence sequence NN cord-329844-w969lczb 350 7 and and CC cord-329844-w969lczb 350 8 assign assign VB cord-329844-w969lczb 350 9 it -PRON- PRP cord-329844-w969lczb 350 10 the the DT cord-329844-w969lczb 350 11 parameter parameter NN cord-329844-w969lczb 350 12 0,1,2,3 0,1,2,3 XX cord-329844-w969lczb 350 13 , , , cord-329844-w969lczb 350 14 or or CC cord-329844-w969lczb 350 15 4 4 CD cord-329844-w969lczb 350 16 of of IN cord-329844-w969lczb 350 17 the the DT cord-329844-w969lczb 350 18 SABR SABR NNP cord-329844-w969lczb 350 19 - - HYPH cord-329844-w969lczb 350 20 P p NN cord-329844-w969lczb 350 21 prediction prediction NN cord-329844-w969lczb 350 22 method method NN cord-329844-w969lczb 350 23 refined refined JJ cord-329844-w969lczb 350 24 parameter parameter NN cord-329844-w969lczb 350 25 ( ( -LRB- cord-329844-w969lczb 350 26 last last JJ cord-329844-w969lczb 350 27 column column NN cord-329844-w969lczb 350 28 of of IN cord-329844-w969lczb 350 29 Table Table NNP cord-329844-w969lczb 350 30 1 1 CD cord-329844-w969lczb 350 31 ) ) -RRB- cord-329844-w969lczb 350 32 . . . cord-329844-w969lczb 351 1 ( ( -LRB- cord-329844-w969lczb 351 2 2 2 LS cord-329844-w969lczb 351 3 ) ) -RRB- cord-329844-w969lczb 352 1 Basic basic JJ cord-329844-w969lczb 352 2 Motif Motif NNP cord-329844-w969lczb 352 3 Score score NN cord-329844-w969lczb 352 4 . . . cord-329844-w969lczb 353 1 For for IN cord-329844-w969lczb 353 2 each each DT cord-329844-w969lczb 353 3 residue residue NN cord-329844-w969lczb 353 4 number number NN cord-329844-w969lczb 353 5 i i PRP cord-329844-w969lczb 353 6 , , , cord-329844-w969lczb 353 7 obtain obtain VB cord-329844-w969lczb 353 8 a a DT cord-329844-w969lczb 353 9 score score NN cord-329844-w969lczb 353 10 by by IN cord-329844-w969lczb 353 11 summing sum VBG cord-329844-w969lczb 353 12 over over RP cord-329844-w969lczb 353 13 the the DT cord-329844-w969lczb 353 14 run run NN cord-329844-w969lczb 353 15 of of IN cord-329844-w969lczb 353 16 17 17 CD cord-329844-w969lczb 353 17 residues residue NNS cord-329844-w969lczb 353 18 of of IN cord-329844-w969lczb 353 19 which which WDT cord-329844-w969lczb 353 20 i i PRP cord-329844-w969lczb 353 21 is be VBZ cord-329844-w969lczb 353 22 the the DT cord-329844-w969lczb 353 23 central central JJ cord-329844-w969lczb 353 24 ( ( -LRB- cord-329844-w969lczb 353 25 9 9 CD cord-329844-w969lczb 353 26 th th CD cord-329844-w969lczb 353 27 ) ) -RRB- cord-329844-w969lczb 353 28 residue residue NN cord-329844-w969lczb 353 29 and and CC cord-329844-w969lczb 353 30 assign assign VB cord-329844-w969lczb 353 31 the the DT cord-329844-w969lczb 353 32 resulting result VBG cord-329844-w969lczb 353 33 sum sum NN cord-329844-w969lczb 353 34 ( ( -LRB- cord-329844-w969lczb 353 35 the the DT cord-329844-w969lczb 353 36 score score NN cord-329844-w969lczb 353 37 ) ) -RRB- cord-329844-w969lczb 353 38 to to IN cord-329844-w969lczb 353 39 each each DT cord-329844-w969lczb 353 40 residue residue NN cord-329844-w969lczb 354 1 i i PRP cord-329844-w969lczb 354 2 ( ( -LRB- cord-329844-w969lczb 354 3 providing provide VBG cord-329844-w969lczb 354 4 that that IN cord-329844-w969lczb 354 5 a a DT cord-329844-w969lczb 354 6 residue residue NN cord-329844-w969lczb 354 7 numbers number NNS cord-329844-w969lczb 354 8 i-8 i-8 NN cord-329844-w969lczb 354 9 , , , cord-329844-w969lczb 354 10 i-7 i-7 NNP cord-329844-w969lczb 354 11 etc etc FW cord-329844-w969lczb 354 12 . . . cord-329844-w969lczb 355 1 up up IN cord-329844-w969lczb 355 2 to to IN cord-329844-w969lczb 355 3 i+8 i+8 NNP cord-329844-w969lczb 355 4 lies lie NNS cord-329844-w969lczb 355 5 within within IN cord-329844-w969lczb 355 6 the the DT cord-329844-w969lczb 355 7 sequence sequence NN cord-329844-w969lczb 355 8 ) ) -RRB- cord-329844-w969lczb 355 9 . . . cord-329844-w969lczb 356 1 [ [ -LRB- cord-329844-w969lczb 356 2 20 20 CD cord-329844-w969lczb 356 3 ] ] -RRB- cord-329844-w969lczb 356 4 by by IN cord-329844-w969lczb 356 5 repeating repeat VBG cord-329844-w969lczb 356 6 step step NN cord-329844-w969lczb 356 7 ( ( -LRB- cord-329844-w969lczb 356 8 2 2 LS cord-329844-w969lczb 356 9 ) ) -RRB- cord-329844-w969lczb 356 10 with with IN cord-329844-w969lczb 356 11 the the DT cord-329844-w969lczb 356 12 resulting result VBG cord-329844-w969lczb 356 13 scores score NNS cord-329844-w969lczb 356 14 , , , cord-329844-w969lczb 356 15 but but CC cord-329844-w969lczb 356 16 do do VBP cord-329844-w969lczb 356 17 not not RB cord-329844-w969lczb 356 18 add add VB cord-329844-w969lczb 356 19 the the DT cord-329844-w969lczb 356 20 basic basic JJ cord-329844-w969lczb 356 21 motif motif NN cord-329844-w969lczb 356 22 score score NN cord-329844-w969lczb 356 23 for for IN cord-329844-w969lczb 356 24 each each DT cord-329844-w969lczb 356 25 residue residue NN cord-329844-w969lczb 356 26 i i PRP cord-329844-w969lczb 356 27 to to IN cord-329844-w969lczb 356 28 itself -PRON- PRP cord-329844-w969lczb 356 29 . . . cord-329844-w969lczb 357 1 More more RBR cord-329844-w969lczb 357 2 specifically specifically RB cord-329844-w969lczb 357 3 stated state VBN cord-329844-w969lczb 357 4 , , , cord-329844-w969lczb 357 5 examine examine VB cord-329844-w969lczb 357 6 the the DT cord-329844-w969lczb 357 7 above above JJ cord-329844-w969lczb 357 8 basic basic JJ cord-329844-w969lczb 357 9 motif motif NN cord-329844-w969lczb 357 10 score score NN cord-329844-w969lczb 357 11 for for IN cord-329844-w969lczb 357 12 each each DT cord-329844-w969lczb 358 1 i i PRP cord-329844-w969lczb 358 2 th th XX cord-329844-w969lczb 358 3 residue residue NN cord-329844-w969lczb 358 4 from from IN cord-329844-w969lczb 358 5 i=1 i=1 NNS cord-329844-w969lczb 358 6 to to TO cord-329844-w969lczb 358 7 end end NN cord-329844-w969lczb 358 8 of of IN cord-329844-w969lczb 358 9 sequence sequence NN cord-329844-w969lczb 358 10 in in IN cord-329844-w969lczb 358 11 turn turn NN cord-329844-w969lczb 358 12 , , , cord-329844-w969lczb 358 13 and and CC cord-329844-w969lczb 358 14 add add VB cord-329844-w969lczb 358 15 it -PRON- PRP cord-329844-w969lczb 358 16 to to IN cord-329844-w969lczb 358 17 the the DT cord-329844-w969lczb 358 18 score score NN cord-329844-w969lczb 358 19 of of IN cord-329844-w969lczb 358 20 the the DT cord-329844-w969lczb 358 21 residue residue NN cord-329844-w969lczb 358 22 at at IN cord-329844-w969lczb 358 23 i-8 i-8 NNP cord-329844-w969lczb 358 24 , , , cord-329844-w969lczb 358 25 i-7 i-7 NNP cord-329844-w969lczb 358 26 , , , cord-329844-w969lczb 358 27 etc etc FW cord-329844-w969lczb 358 28 up up IN cord-329844-w969lczb 358 29 to to IN cord-329844-w969lczb 358 30 i-1 i-1 NNP cord-329844-w969lczb 358 31 , , , cord-329844-w969lczb 358 32 and and CC cord-329844-w969lczb 358 33 to to IN cord-329844-w969lczb 358 34 the the DT cord-329844-w969lczb 358 35 score score NN cord-329844-w969lczb 358 36 of of IN cord-329844-w969lczb 358 37 the the DT cord-329844-w969lczb 358 38 residue residue NN cord-329844-w969lczb 358 39 i+1 i+1 NN cord-329844-w969lczb 358 40 , , , cord-329844-w969lczb 358 41 i+2 i+2 NN cord-329844-w969lczb 358 42 , , , cord-329844-w969lczb 358 43 etc etc FW cord-329844-w969lczb 358 44 . . . cord-329844-w969lczb 359 1 up up IN cord-329844-w969lczb 359 2 to to IN cord-329844-w969lczb 359 3 i+8 i+8 PRP cord-329844-w969lczb 359 4 ( ( -LRB- cord-329844-w969lczb 359 5 providing provide VBG cord-329844-w969lczb 359 6 that that IN cord-329844-w969lczb 359 7 the the DT cord-329844-w969lczb 359 8 residue residue NN cord-329844-w969lczb 359 9 numbers number NNS cord-329844-w969lczb 359 10 i-8 i-8 NN cord-329844-w969lczb 359 11 etc etc FW cord-329844-w969lczb 359 12 . . . cord-329844-w969lczb 360 1 lie lie VB cord-329844-w969lczb 360 2 within within IN cord-329844-w969lczb 360 3 the the DT cord-329844-w969lczb 360 4 sequence sequence NN cord-329844-w969lczb 360 5 ) ) -RRB- cord-329844-w969lczb 360 6 . . . cord-329844-w969lczb 361 1 ( ( -LRB- cord-329844-w969lczb 361 2 4 4 LS cord-329844-w969lczb 361 3 ) ) -RRB- cord-329844-w969lczb 361 4 Normalized normalize VBN cord-329844-w969lczb 361 5 Score score NN cord-329844-w969lczb 361 6 as as IN cord-329844-w969lczb 361 7 SABR SABR NNP cord-329844-w969lczb 361 8 - - HYPH cord-329844-w969lczb 361 9 P p NN cord-329844-w969lczb 361 10 propensity propensity NN cord-329844-w969lczb 361 11 . . . cord-329844-w969lczb 362 1 Examine examine VB cord-329844-w969lczb 362 2 each each DT cord-329844-w969lczb 362 3 smoothed smooth VBN cord-329844-w969lczb 362 4 score score NN cord-329844-w969lczb 362 5 resulting result VBG cord-329844-w969lczb 362 6 from from IN cord-329844-w969lczb 362 7 the the DT cord-329844-w969lczb 362 8 above above JJ cord-329844-w969lczb 362 9 for for IN cord-329844-w969lczb 362 10 each each DT cord-329844-w969lczb 362 11 residue residue NN cord-329844-w969lczb 362 12 i i NN cord-329844-w969lczb 362 13 , , , cord-329844-w969lczb 362 14 and and CC cord-329844-w969lczb 362 15 divide divide VB cord-329844-w969lczb 362 16 by by IN cord-329844-w969lczb 362 17 300 300 CD cord-329844-w969lczb 362 18 . . . cord-329844-w969lczb 363 1 This this DT cord-329844-w969lczb 363 2 is be VBZ cord-329844-w969lczb 363 3 the the DT cord-329844-w969lczb 363 4 current current JJ cord-329844-w969lczb 363 5 value value NN cord-329844-w969lczb 363 6 of of IN cord-329844-w969lczb 363 7 the the DT cord-329844-w969lczb 363 8 optimized optimize VBN cord-329844-w969lczb 363 9 normalization normalization NN cord-329844-w969lczb 363 10 parameter parameter NN cord-329844-w969lczb 363 11 that that WDT cord-329844-w969lczb 363 12 sets set VBZ cord-329844-w969lczb 363 13 the the DT cord-329844-w969lczb 363 14 threshold threshold NN cord-329844-w969lczb 363 15 as as IN cord-329844-w969lczb 363 16 100 100 CD cord-329844-w969lczb 363 17 above above IN cord-329844-w969lczb 363 18 which which WDT cord-329844-w969lczb 363 19 sialic sialic JJ cord-329844-w969lczb 363 20 acid acid NN cord-329844-w969lczb 363 21 glycan glycan NN cord-329844-w969lczb 363 22 binding binding NN cord-329844-w969lczb 363 23 is be VBZ cord-329844-w969lczb 363 24 predicted predict VBN cord-329844-w969lczb 363 25 . . . cord-329844-w969lczb 364 1 ( ( -LRB- cord-329844-w969lczb 364 2 5 5 LS cord-329844-w969lczb 364 3 ) ) -RRB- cord-329844-w969lczb 364 4 Reporting reporting NN cord-329844-w969lczb 364 5 . . . cord-329844-w969lczb 365 1 The the DT cord-329844-w969lczb 365 2 normalized normalized JJ cord-329844-w969lczb 365 3 score score NN cord-329844-w969lczb 365 4 ( ( -LRB- cord-329844-w969lczb 365 5 SABR SABR NNP cord-329844-w969lczb 365 6 - - HYPH cord-329844-w969lczb 365 7 P p NN cord-329844-w969lczb 365 8 propensity propensity NN cord-329844-w969lczb 365 9 ) ) -RRB- cord-329844-w969lczb 365 10 is be VBZ cord-329844-w969lczb 365 11 plotted plot VBN cord-329844-w969lczb 365 12 as as IN cord-329844-w969lczb 365 13 a a DT cord-329844-w969lczb 365 14 function function NN cord-329844-w969lczb 365 15 of of IN cord-329844-w969lczb 365 16 residue residue JJ cord-329844-w969lczb 365 17 number number NN cord-329844-w969lczb 365 18 from from IN cord-329844-w969lczb 365 19 1 1 CD cord-329844-w969lczb 365 20 to to IN cord-329844-w969lczb 365 21 end end NN cord-329844-w969lczb 365 22 of of IN cord-329844-w969lczb 365 23 the the DT cord-329844-w969lczb 365 24 sequence sequence NN cord-329844-w969lczb 365 25 , , , cord-329844-w969lczb 365 26 i.e. i.e. FW cord-329844-w969lczb 365 27 as as IN cord-329844-w969lczb 365 28 a a DT cord-329844-w969lczb 365 29 " " `` cord-329844-w969lczb 365 30 SABR SABR NNP cord-329844-w969lczb 365 31 - - HYPH cord-329844-w969lczb 365 32 P p NN cord-329844-w969lczb 365 33 propensity propensity NN cord-329844-w969lczb 365 34 plot plot NN cord-329844-w969lczb 365 35 " " '' cord-329844-w969lczb 365 36 . . . cord-329844-w969lczb 366 1 The the DT cord-329844-w969lczb 366 2 actual actual JJ cord-329844-w969lczb 366 3 predictions prediction NNS cord-329844-w969lczb 366 4 are be VBP cord-329844-w969lczb 366 5 also also RB cord-329844-w969lczb 366 6 written write VBN cord-329844-w969lczb 366 7 out out RP cord-329844-w969lczb 366 8 separately separately RB cord-329844-w969lczb 366 9 as as IN cord-329844-w969lczb 366 10 text text NN cord-329844-w969lczb 366 11 and and CC cord-329844-w969lczb 366 12 these these DT cord-329844-w969lczb 366 13 report report VBP cord-329844-w969lczb 366 14 only only RB cord-329844-w969lczb 366 15 the the DT cord-329844-w969lczb 366 16 amino amino NN cord-329844-w969lczb 366 17 acid acid NN cord-329844-w969lczb 366 18 residue residue NN cord-329844-w969lczb 366 19 ( ( -LRB- cord-329844-w969lczb 366 20 as as IN cord-329844-w969lczb 366 21 G G NNP cord-329844-w969lczb 366 22 , , , cord-329844-w969lczb 366 23 A A NNP cord-329844-w969lczb 366 24 , , , cord-329844-w969lczb 366 25 V v NN cord-329844-w969lczb 366 26 , , , cord-329844-w969lczb 366 27 etc etc FW cord-329844-w969lczb 366 28 . . . cord-329844-w969lczb 366 29 ) ) -RRB- cord-329844-w969lczb 367 1 along along IN cord-329844-w969lczb 367 2 with with IN cord-329844-w969lczb 367 3 the the DT cord-329844-w969lczb 367 4 score score NN cord-329844-w969lczb 367 5 , , , cord-329844-w969lczb 367 6 for for IN cord-329844-w969lczb 367 7 those those DT cord-329844-w969lczb 367 8 residues residue NNS cord-329844-w969lczb 367 9 for for IN cord-329844-w969lczb 367 10 which which WDT cord-329844-w969lczb 367 11 the the DT cord-329844-w969lczb 367 12 normalized normalize VBN cord-329844-w969lczb 367 13 scores score NNS cord-329844-w969lczb 367 14 exceed exceed VBP cord-329844-w969lczb 367 15 100 100 CD cord-329844-w969lczb 367 16 . . . cord-329844-w969lczb 368 1 Particularly particularly RB cord-329844-w969lczb 368 2 because because IN cord-329844-w969lczb 368 3 of of IN cord-329844-w969lczb 368 4 step step NN cord-329844-w969lczb 368 5 ( ( -LRB- cord-329844-w969lczb 368 6 3 3 CD cord-329844-w969lczb 368 7 ) ) -RRB- cord-329844-w969lczb 368 8 , , , cord-329844-w969lczb 368 9 these these DT cord-329844-w969lczb 368 10 will will MD cord-329844-w969lczb 368 11 tend tend VB cord-329844-w969lczb 368 12 to to TO cord-329844-w969lczb 368 13 occur occur VB cord-329844-w969lczb 368 14 conveniently conveniently RB cord-329844-w969lczb 368 15 in in IN cord-329844-w969lczb 368 16 runs run NNS cord-329844-w969lczb 368 17 of of IN cord-329844-w969lczb 368 18 approximately approximately RB cord-329844-w969lczb 368 19 8 8 CD cord-329844-w969lczb 368 20 - - SYM cord-329844-w969lczb 368 21 18 18 CD cord-329844-w969lczb 368 22 contiguous contiguous JJ cord-329844-w969lczb 368 23 residues residue NNS cord-329844-w969lczb 368 24 , , , cord-329844-w969lczb 368 25 but but CC cord-329844-w969lczb 368 26 sometimes sometimes RB cord-329844-w969lczb 368 27 shorter short JJR cord-329844-w969lczb 368 28 . . . cord-329844-w969lczb 369 1 In in IN cord-329844-w969lczb 369 2 the the DT cord-329844-w969lczb 369 3 present present JJ cord-329844-w969lczb 369 4 study study NN cord-329844-w969lczb 369 5 the the DT cord-329844-w969lczb 369 6 normalized normalized JJ cord-329844-w969lczb 369 7 score score NN cord-329844-w969lczb 369 8 was be VBD cord-329844-w969lczb 369 9 formalized formalize VBN cord-329844-w969lczb 369 10 as as IN cord-329844-w969lczb 369 11 a a DT cord-329844-w969lczb 369 12 simple simple JJ cord-329844-w969lczb 369 13 measure measure NN cord-329844-w969lczb 369 14 by by IN cord-329844-w969lczb 369 15 rounding round VBG cord-329844-w969lczb 369 16 to to IN cord-329844-w969lczb 369 17 the the DT cord-329844-w969lczb 369 18 nearest near JJS cord-329844-w969lczb 369 19 integer integer NN cord-329844-w969lczb 369 20 prior prior RB cord-329844-w969lczb 369 21 to to IN cord-329844-w969lczb 369 22 reporting reporting NN cord-329844-w969lczb 369 23 , , , cord-329844-w969lczb 369 24 though though IN cord-329844-w969lczb 369 25 this this DT cord-329844-w969lczb 369 26 made make VBD cord-329844-w969lczb 369 27 no no DT cord-329844-w969lczb 369 28 significant significant JJ cord-329844-w969lczb 369 29 difference difference NN cord-329844-w969lczb 369 30 in in IN cord-329844-w969lczb 369 31 the the DT cord-329844-w969lczb 369 32 present present JJ cord-329844-w969lczb 369 33 paper paper NN cord-329844-w969lczb 369 34 . . . cord-329844-w969lczb 370 1 This this DT cord-329844-w969lczb 370 2 simple simple JJ cord-329844-w969lczb 370 3 approach approach NN cord-329844-w969lczb 370 4 will will MD cord-329844-w969lczb 370 5 be be VB cord-329844-w969lczb 370 6 better well RBR cord-329844-w969lczb 370 7 developed develop VBN cord-329844-w969lczb 370 8 as as IN cord-329844-w969lczb 370 9 a a DT cord-329844-w969lczb 370 10 GOR GOR NNP cord-329844-w969lczb 370 11 - - HYPH cord-329844-w969lczb 370 12 like like JJ cord-329844-w969lczb 370 13 method method NN cord-329844-w969lczb 370 14 , , , cord-329844-w969lczb 370 15 but but CC cord-329844-w969lczb 370 16 for for IN cord-329844-w969lczb 370 17 present present JJ cord-329844-w969lczb 370 18 purposes purpose NNS cord-329844-w969lczb 370 19 it -PRON- PRP cord-329844-w969lczb 370 20 suffices suffice VBZ cord-329844-w969lczb 370 21 to to TO cord-329844-w969lczb 370 22 give give VB cord-329844-w969lczb 370 23 an an DT cord-329844-w969lczb 370 24 estimate estimate NN cord-329844-w969lczb 370 25 of of IN cord-329844-w969lczb 370 26 the the DT cord-329844-w969lczb 370 27 likely likely JJ cord-329844-w969lczb 370 28 sialic sialic JJ cord-329844-w969lczb 370 29 acid acid NN cord-329844-w969lczb 370 30 glycan glycan NN cord-329844-w969lczb 370 31 binding bind VBG cord-329844-w969lczb 370 32 domains domain NNS cord-329844-w969lczb 370 33 on on IN cord-329844-w969lczb 370 34 the the DT cord-329844-w969lczb 370 35 spike spike NN cord-329844-w969lczb 370 36 protein protein NN cord-329844-w969lczb 370 37 and and CC cord-329844-w969lczb 370 38 proceed proceed VB cord-329844-w969lczb 370 39 with with IN cord-329844-w969lczb 370 40 further further JJ cord-329844-w969lczb 370 41 investigations investigation NNS cord-329844-w969lczb 370 42 and and CC cord-329844-w969lczb 370 43 results result NNS cord-329844-w969lczb 370 44 described describe VBN cord-329844-w969lczb 370 45 below below RB cord-329844-w969lczb 370 46 . . . cord-329844-w969lczb 371 1 At at IN cord-329844-w969lczb 371 2 the the DT cord-329844-w969lczb 371 3 above above RB cord-329844-w969lczb 371 4 optimized optimize VBN cord-329844-w969lczb 371 5 threshold threshold NN cord-329844-w969lczb 371 6 , , , cord-329844-w969lczb 371 7 this this DT cord-329844-w969lczb 371 8 the the DT cord-329844-w969lczb 371 9 example example NN cord-329844-w969lczb 371 10 SABR SABR NNP cord-329844-w969lczb 371 11 - - HYPH cord-329844-w969lczb 371 12 P p NN cord-329844-w969lczb 371 13 propensity propensity NN cord-329844-w969lczb 371 14 plots plot NNS cord-329844-w969lczb 371 15 shown show VBN cord-329844-w969lczb 371 16 in in IN cord-329844-w969lczb 371 17 Fig Fig NNP cord-329844-w969lczb 371 18 . . . cord-329844-w969lczb 372 1 4 4 LS cord-329844-w969lczb 372 2 . . . cord-329844-w969lczb 373 1 The the DT cord-329844-w969lczb 373 2 initial initial JJ cord-329844-w969lczb 373 3 studies study NNS cord-329844-w969lczb 373 4 using use VBG cord-329844-w969lczb 373 5 a a DT cord-329844-w969lczb 373 6 random random JJ cord-329844-w969lczb 373 7 selection selection NN cord-329844-w969lczb 373 8 ( ( -LRB- cord-329844-w969lczb 373 9 more more RBR cord-329844-w969lczb 373 10 correctly correctly RB cord-329844-w969lczb 373 11 stated state VBN cord-329844-w969lczb 373 12 , , , cord-329844-w969lczb 373 13 an an DT cord-329844-w969lczb 373 14 arbitrary arbitrary JJ cord-329844-w969lczb 373 15 selection selection NN cord-329844-w969lczb 373 16 ) ) -RRB- cord-329844-w969lczb 373 17 of of IN cord-329844-w969lczb 373 18 proteins protein NNS cord-329844-w969lczb 373 19 except except IN cord-329844-w969lczb 373 20 that that IN cord-329844-w969lczb 373 21 a a DT cord-329844-w969lczb 373 22 predominance predominance NN cord-329844-w969lczb 373 23 of of IN cord-329844-w969lczb 373 24 sialic sialic JJ cord-329844-w969lczb 373 25 acid acid NN cord-329844-w969lczb 373 26 or or CC cord-329844-w969lczb 373 27 sialic sialic JJ cord-329844-w969lczb 373 28 acid acid NN cord-329844-w969lczb 373 29 glycan glycan NN cord-329844-w969lczb 373 30 binding bind VBG cord-329844-w969lczb 373 31 proteins protein NNS cord-329844-w969lczb 373 32 were be VBD cord-329844-w969lczb 373 33 sought seek VBN cord-329844-w969lczb 373 34 , , , cord-329844-w969lczb 373 35 the the DT cord-329844-w969lczb 373 36 method method NN cord-329844-w969lczb 373 37 initially initially RB cord-329844-w969lczb 373 38 gave give VBD cord-329844-w969lczb 373 39 18 18 CD cord-329844-w969lczb 373 40 true true JJ cord-329844-w969lczb 373 41 positives positive NNS cord-329844-w969lczb 373 42 out out IN cord-329844-w969lczb 373 43 of of IN cord-329844-w969lczb 373 44 20 20 CD cord-329844-w969lczb 373 45 proteins protein NNS cord-329844-w969lczb 373 46 representing represent VBG cord-329844-w969lczb 373 47 group group NN cord-329844-w969lczb 373 48 A A NNP cord-329844-w969lczb 373 49 , , , cord-329844-w969lczb 373 50 i.e. i.e. FW cord-329844-w969lczb 373 51 those those DT cord-329844-w969lczb 373 52 that that WDT cord-329844-w969lczb 373 53 are be VBP cord-329844-w969lczb 373 54 known know VBN cord-329844-w969lczb 373 55 to to TO cord-329844-w969lczb 373 56 bind bind VB cord-329844-w969lczb 373 57 sialic sialic JJ cord-329844-w969lczb 373 58 acids acid NNS cord-329844-w969lczb 373 59 or or CC cord-329844-w969lczb 373 60 glycan glycan NN cord-329844-w969lczb 373 61 molecules molecule NNS cord-329844-w969lczb 373 62 containing contain VBG cord-329844-w969lczb 373 63 them -PRON- PRP cord-329844-w969lczb 373 64 , , , cord-329844-w969lczb 373 65 10 10 CD cord-329844-w969lczb 373 66 true true JJ cord-329844-w969lczb 373 67 negatives negative NNS cord-329844-w969lczb 373 68 for for IN cord-329844-w969lczb 373 69 prediction prediction NN cord-329844-w969lczb 373 70 of of IN cord-329844-w969lczb 373 71 the the DT cord-329844-w969lczb 373 72 above above JJ cord-329844-w969lczb 373 73 same same JJ cord-329844-w969lczb 373 74 kind kind NN cord-329844-w969lczb 373 75 of of IN cord-329844-w969lczb 373 76 sialic sialic JJ cord-329844-w969lczb 373 77 acid acid NN cord-329844-w969lczb 373 78 binding bind VBG cord-329844-w969lczb 373 79 out out IN cord-329844-w969lczb 373 80 of of IN cord-329844-w969lczb 373 81 group group NN cord-329844-w969lczb 373 82 B b NN cord-329844-w969lczb 373 83 , , , cord-329844-w969lczb 373 84 i.e. i.e. FW cord-329844-w969lczb 373 85 10 10 CD cord-329844-w969lczb 373 86 proteins protein NNS cord-329844-w969lczb 373 87 believed believe VBN cord-329844-w969lczb 373 88 not not RB cord-329844-w969lczb 373 89 to to TO cord-329844-w969lczb 373 90 bind bind VB cord-329844-w969lczb 373 91 any any DT cord-329844-w969lczb 373 92 kinds kind NNS cord-329844-w969lczb 373 93 of of IN cord-329844-w969lczb 373 94 sugars sugar NNS cord-329844-w969lczb 373 95 significantly significantly RB cord-329844-w969lczb 373 96 , , , cord-329844-w969lczb 373 97 and and CC cord-329844-w969lczb 373 98 6 6 CD cord-329844-w969lczb 373 99 true true JJ cord-329844-w969lczb 373 100 negatives negative NNS cord-329844-w969lczb 373 101 for for IN cord-329844-w969lczb 373 102 the the DT cord-329844-w969lczb 373 103 10 10 CD cord-329844-w969lczb 373 104 proteins protein NNS cord-329844-w969lczb 373 105 comprising comprise VBG cord-329844-w969lczb 373 106 group group NN cord-329844-w969lczb 373 107 C C NNP cord-329844-w969lczb 373 108 , , , cord-329844-w969lczb 373 109 i.e. i.e. FW cord-329844-w969lczb 373 110 proteins protein NNS cord-329844-w969lczb 373 111 that that WDT cord-329844-w969lczb 373 112 bind bind VBP cord-329844-w969lczb 373 113 sugars sugar NNS cord-329844-w969lczb 373 114 but but CC cord-329844-w969lczb 373 115 not not RB cord-329844-w969lczb 373 116 those those DT cord-329844-w969lczb 373 117 containing contain VBG cord-329844-w969lczb 373 118 sialic sialic JJ cord-329844-w969lczb 373 119 acids acid NNS cord-329844-w969lczb 373 120 , , , cord-329844-w969lczb 373 121 and and CC cord-329844-w969lczb 373 122 so so RB cord-329844-w969lczb 373 123 representing represent VBG cord-329844-w969lczb 373 124 the the DT cord-329844-w969lczb 373 125 biggest big JJS cord-329844-w969lczb 373 126 challenge challenge NN cord-329844-w969lczb 373 127 . . . cord-329844-w969lczb 374 1 This this DT cord-329844-w969lczb 374 2 initial initial JJ cord-329844-w969lczb 374 3 result result NN cord-329844-w969lczb 374 4 represented represent VBD cord-329844-w969lczb 374 5 85 85 CD cord-329844-w969lczb 374 6 % % NN cord-329844-w969lczb 374 7 accuracy accuracy NN cord-329844-w969lczb 374 8 , , , cord-329844-w969lczb 374 9 82 82 CD cord-329844-w969lczb 374 10 % % NN cord-329844-w969lczb 374 11 sensitivity sensitivity NN cord-329844-w969lczb 374 12 , , , cord-329844-w969lczb 374 13 and and CC cord-329844-w969lczb 374 14 80 80 CD cord-329844-w969lczb 374 15 % % NN cord-329844-w969lczb 374 16 specificity specificity NN cord-329844-w969lczb 374 17 , , , cord-329844-w969lczb 374 18 a a DT cord-329844-w969lczb 374 19 reasonable reasonable JJ cord-329844-w969lczb 374 20 preliminary preliminary JJ cord-329844-w969lczb 374 21 result result NN cord-329844-w969lczb 374 22 for for IN cord-329844-w969lczb 374 23 such such PDT cord-329844-w969lczb 374 24 a a DT cord-329844-w969lczb 374 25 simple simple JJ cord-329844-w969lczb 374 26 model model NN cord-329844-w969lczb 374 27 . . . cord-329844-w969lczb 375 1 Note note VB cord-329844-w969lczb 375 2 that that IN cord-329844-w969lczb 375 3 there there EX cord-329844-w969lczb 375 4 were be VBD cord-329844-w969lczb 375 5 initially initially RB cord-329844-w969lczb 375 6 no no DT cord-329844-w969lczb 375 7 false false JJ cord-329844-w969lczb 375 8 negatives negative NNS cord-329844-w969lczb 375 9 for for IN cord-329844-w969lczb 375 10 those those DT cord-329844-w969lczb 375 11 proteins protein NNS cord-329844-w969lczb 375 12 not not RB cord-329844-w969lczb 375 13 believed believe VBN cord-329844-w969lczb 375 14 to to TO cord-329844-w969lczb 375 15 bind bind VB cord-329844-w969lczb 375 16 any any DT cord-329844-w969lczb 375 17 kinds kind NNS cord-329844-w969lczb 375 18 of of IN cord-329844-w969lczb 375 19 sugars sugar NNS cord-329844-w969lczb 375 20 , , , cord-329844-w969lczb 375 21 so so IN cord-329844-w969lczb 375 22 a a DT cord-329844-w969lczb 375 23 specific specific JJ cord-329844-w969lczb 375 24 search search NN cord-329844-w969lczb 375 25 for for IN cord-329844-w969lczb 375 26 at at RB cord-329844-w969lczb 375 27 least least RBS cord-329844-w969lczb 375 28 one one CD cord-329844-w969lczb 375 29 case case NN cord-329844-w969lczb 375 30 of of IN cord-329844-w969lczb 375 31 a a DT cord-329844-w969lczb 375 32 false false JJ cord-329844-w969lczb 375 33 negative negative NN cord-329844-w969lczb 375 34 ( ( -LRB- cord-329844-w969lczb 375 35 discussed discuss VBN cord-329844-w969lczb 375 36 below below IN cord-329844-w969lczb 375 37 ) ) -RRB- cord-329844-w969lczb 375 38 , , , cord-329844-w969lczb 375 39 which which WDT cord-329844-w969lczb 375 40 is be VBZ cord-329844-w969lczb 375 41 strictly strictly RB cord-329844-w969lczb 375 42 speaking speak VBG cord-329844-w969lczb 375 43 a a DT cord-329844-w969lczb 375 44 bias bias NN cord-329844-w969lczb 375 45 , , , cord-329844-w969lczb 375 46 dropped drop VBD cord-329844-w969lczb 375 47 the the DT cord-329844-w969lczb 375 48 prediction prediction NN cord-329844-w969lczb 375 49 quality quality NN cord-329844-w969lczb 375 50 to to IN cord-329844-w969lczb 375 51 83 83 CD cord-329844-w969lczb 375 52 % % NN cord-329844-w969lczb 375 53 accuracy accuracy NN cord-329844-w969lczb 375 54 , , , cord-329844-w969lczb 375 55 sensitivity sensitivity NN cord-329844-w969lczb 375 56 82 82 CD cord-329844-w969lczb 375 57 % % NN cord-329844-w969lczb 375 58 , , , cord-329844-w969lczb 375 59 and and CC cord-329844-w969lczb 375 60 76 76 CD cord-329844-w969lczb 375 61 % % NN cord-329844-w969lczb 375 62 specificity specificity NN cord-329844-w969lczb 375 63 . . . cord-329844-w969lczb 376 1 A a DT cord-329844-w969lczb 376 2 recent recent JJ cord-329844-w969lczb 376 3 number number NN cord-329844-w969lczb 376 4 of of IN cord-329844-w969lczb 376 5 further further JJ cord-329844-w969lczb 376 6 studies study NNS cord-329844-w969lczb 376 7 exemplified exemplify VBN cord-329844-w969lczb 376 8 in in IN cord-329844-w969lczb 376 9 the the DT cord-329844-w969lczb 376 10 discussion discussion NN cord-329844-w969lczb 376 11 below below RB cord-329844-w969lczb 376 12 were be VBD cord-329844-w969lczb 376 13 also also RB cord-329844-w969lczb 376 14 , , , cord-329844-w969lczb 376 15 strictly strictly RB cord-329844-w969lczb 376 16 speaking speak VBG cord-329844-w969lczb 376 17 , , , cord-329844-w969lczb 376 18 a a DT cord-329844-w969lczb 376 19 bias bias NN cord-329844-w969lczb 376 20 including include VBG cord-329844-w969lczb 376 21 comparisons comparison NNS cord-329844-w969lczb 376 22 between between IN cord-329844-w969lczb 376 23 weakly weakly RB cord-329844-w969lczb 376 24 homologous homologous JJ cord-329844-w969lczb 376 25 proteins protein NNS cord-329844-w969lczb 376 26 , , , cord-329844-w969lczb 376 27 extended extend VBD cord-329844-w969lczb 376 28 the the DT cord-329844-w969lczb 376 29 sample sample NN cord-329844-w969lczb 376 30 to to IN cord-329844-w969lczb 376 31 80 80 CD cord-329844-w969lczb 376 32 proteins protein NNS cord-329844-w969lczb 376 33 and and CC cord-329844-w969lczb 376 34 reproduced reproduce VBD cord-329844-w969lczb 376 35 the the DT cord-329844-w969lczb 376 36 original original JJ cord-329844-w969lczb 376 37 quality quality NN cord-329844-w969lczb 376 38 to to IN cord-329844-w969lczb 376 39 within within IN cord-329844-w969lczb 376 40 the the DT cord-329844-w969lczb 376 41 nearest near JJS cord-329844-w969lczb 376 42 percentage percentage NN cord-329844-w969lczb 376 43 : : : cord-329844-w969lczb 376 44 85 85 CD cord-329844-w969lczb 376 45 % % NN cord-329844-w969lczb 376 46 accuracy accuracy NN cord-329844-w969lczb 376 47 , , , cord-329844-w969lczb 376 48 82 82 CD cord-329844-w969lczb 376 49 % % NN cord-329844-w969lczb 376 50 sensitivity sensitivity NN cord-329844-w969lczb 376 51 , , , cord-329844-w969lczb 376 52 and and CC cord-329844-w969lczb 376 53 80 80 CD cord-329844-w969lczb 376 54 % % NN cord-329844-w969lczb 376 55 specificity specificity NN cord-329844-w969lczb 376 56 . . . cord-329844-w969lczb 377 1 Fig Fig NNP cord-329844-w969lczb 377 2 . . . cord-329844-w969lczb 378 1 4 4 LS cord-329844-w969lczb 378 2 . . . cord-329844-w969lczb 379 1 Examples example NNS cord-329844-w969lczb 379 2 of of IN cord-329844-w969lczb 379 3 Prediction Prediction NNP cord-329844-w969lczb 379 4 of of IN cord-329844-w969lczb 379 5 Sialic Sialic NNP cord-329844-w969lczb 379 6 Acid Acid NNP cord-329844-w969lczb 379 7 Binding Binding NNP cord-329844-w969lczb 379 8 Sites site NNS cord-329844-w969lczb 379 9 by by IN cord-329844-w969lczb 379 10 SABR SABR NNP cord-329844-w969lczb 379 11 - - HYPH cord-329844-w969lczb 379 12 P. p. NN cord-329844-w969lczb 380 1 In in IN cord-329844-w969lczb 380 2 each each DT cord-329844-w969lczb 380 3 case case NN cord-329844-w969lczb 380 4 , , , cord-329844-w969lczb 380 5 the the DT cord-329844-w969lczb 380 6 abscissa abscissa NN cord-329844-w969lczb 380 7 ( ( -LRB- cord-329844-w969lczb 380 8 x x NN cord-329844-w969lczb 380 9 axis axis NN cord-329844-w969lczb 380 10 ) ) -RRB- cord-329844-w969lczb 380 11 is be VBZ cord-329844-w969lczb 380 12 the the DT cord-329844-w969lczb 380 13 distance distance NN cord-329844-w969lczb 380 14 along along IN cord-329844-w969lczb 380 15 the the DT cord-329844-w969lczb 380 16 sequence sequence NN cord-329844-w969lczb 380 17 ( ( -LRB- cord-329844-w969lczb 380 18 residue residue NN cord-329844-w969lczb 380 19 number number NN cord-329844-w969lczb 380 20 ) ) -RRB- cord-329844-w969lczb 380 21 and and CC cord-329844-w969lczb 380 22 the the DT cord-329844-w969lczb 380 23 ordinate ordinate NN cord-329844-w969lczb 380 24 ( ( -LRB- cord-329844-w969lczb 380 25 y y NNP cord-329844-w969lczb 380 26 axis axis NN cord-329844-w969lczb 380 27 ) ) -RRB- cord-329844-w969lczb 381 1 is be VBZ cord-329844-w969lczb 381 2 the the DT cord-329844-w969lczb 381 3 predicted predict VBN cord-329844-w969lczb 381 4 sialic sialic JJ cord-329844-w969lczb 381 5 acid acid NN cord-329844-w969lczb 381 6 glycan glycan NN cord-329844-w969lczb 381 7 binding bind VBG cord-329844-w969lczb 381 8 propensity propensity NN cord-329844-w969lczb 381 9 . . . cord-329844-w969lczb 382 1 Scores score NNS cord-329844-w969lczb 382 2 above above IN cord-329844-w969lczb 382 3 a a DT cord-329844-w969lczb 382 4 threshold threshold NN cord-329844-w969lczb 382 5 of of IN cord-329844-w969lczb 382 6 100 100 CD cord-329844-w969lczb 382 7 ( ( -LRB- cord-329844-w969lczb 382 8 red red JJ cord-329844-w969lczb 382 9 line line NN cord-329844-w969lczb 382 10 ) ) -RRB- cord-329844-w969lczb 382 11 for for IN cord-329844-w969lczb 382 12 any any DT cord-329844-w969lczb 382 13 residues residue NNS cord-329844-w969lczb 382 14 are be VBP cord-329844-w969lczb 382 15 taken take VBN cord-329844-w969lczb 382 16 as as IN cord-329844-w969lczb 382 17 a a DT cord-329844-w969lczb 382 18 prediction prediction NN cord-329844-w969lczb 382 19 that that IN cord-329844-w969lczb 382 20 the the DT cord-329844-w969lczb 382 21 domain domain NN cord-329844-w969lczb 382 22 or or CC cord-329844-w969lczb 382 23 protein protein NN cord-329844-w969lczb 382 24 binds bind VBZ cord-329844-w969lczb 382 25 sialic sialic JJ cord-329844-w969lczb 382 26 acid acid NN cord-329844-w969lczb 382 27 glycans glycan NNS cord-329844-w969lczb 382 28 . . . cord-329844-w969lczb 383 1 At at IN cord-329844-w969lczb 383 2 this this DT cord-329844-w969lczb 383 3 stage stage NN cord-329844-w969lczb 383 4 of of IN cord-329844-w969lczb 383 5 the the DT cord-329844-w969lczb 383 6 present present JJ cord-329844-w969lczb 383 7 project project NN cord-329844-w969lczb 383 8 the the DT cord-329844-w969lczb 383 9 predictive predictive JJ cord-329844-w969lczb 383 10 method method NN cord-329844-w969lczb 383 11 was be VBD cord-329844-w969lczb 383 12 only only RB cord-329844-w969lczb 383 13 required require VBN cord-329844-w969lczb 383 14 to to TO cord-329844-w969lczb 383 15 give give VB cord-329844-w969lczb 383 16 approximate approximate JJ cord-329844-w969lczb 383 17 results result NNS cord-329844-w969lczb 383 18 as as IN cord-329844-w969lczb 383 19 guidelines guideline NNS cord-329844-w969lczb 383 20 as as IN cord-329844-w969lczb 383 21 to to IN cord-329844-w969lczb 383 22 the the DT cord-329844-w969lczb 383 23 regions region NNS cord-329844-w969lczb 383 24 the the DT cord-329844-w969lczb 383 25 spike spike NN cord-329844-w969lczb 383 26 protein protein NN cord-329844-w969lczb 383 27 that that WDT cord-329844-w969lczb 383 28 might may MD cord-329844-w969lczb 383 29 be be VB cord-329844-w969lczb 383 30 further further RB cord-329844-w969lczb 383 31 examine examine VB cord-329844-w969lczb 383 32 for for IN cord-329844-w969lczb 383 33 sialic sialic JJ cord-329844-w969lczb 383 34 acid acid NN cord-329844-w969lczb 383 35 glycan glycan NN cord-329844-w969lczb 383 36 binding binding NN cord-329844-w969lczb 383 37 capability capability NN cord-329844-w969lczb 383 38 , , , cord-329844-w969lczb 383 39 but but CC cord-329844-w969lczb 383 40 the the DT cord-329844-w969lczb 383 41 method method NN cord-329844-w969lczb 383 42 appears appear VBZ cord-329844-w969lczb 383 43 promising promise VBG cord-329844-w969lczb 383 44 and and CC cord-329844-w969lczb 383 45 justifies justify VBZ cord-329844-w969lczb 383 46 some some DT cord-329844-w969lczb 383 47 further further JJ cord-329844-w969lczb 383 48 comments comment NNS cord-329844-w969lczb 383 49 and and CC cord-329844-w969lczb 383 50 some some DT cord-329844-w969lczb 383 51 further further JJ cord-329844-w969lczb 383 52 exploratory exploratory JJ cord-329844-w969lczb 383 53 investigation investigation NN cord-329844-w969lczb 383 54 , , , cord-329844-w969lczb 383 55 as as IN cord-329844-w969lczb 383 56 follows follow VBZ cord-329844-w969lczb 383 57 . . . cord-329844-w969lczb 384 1 In in IN cord-329844-w969lczb 384 2 group group NN cord-329844-w969lczb 384 3 A A NNP cord-329844-w969lczb 384 4 , , , cord-329844-w969lczb 384 5 proteins protein NNS cord-329844-w969lczb 384 6 being be VBG cord-329844-w969lczb 384 7 tested test VBN cord-329844-w969lczb 384 8 are be VBP cord-329844-w969lczb 384 9 believed believe VBN cord-329844-w969lczb 384 10 to to TO cord-329844-w969lczb 384 11 be be VB cord-329844-w969lczb 384 12 able able JJ cord-329844-w969lczb 384 13 to to TO cord-329844-w969lczb 384 14 accommodate accommodate VB cord-329844-w969lczb 384 15 sialic sialic JJ cord-329844-w969lczb 384 16 acid acid NN cord-329844-w969lczb 384 17 , , , cord-329844-w969lczb 384 18 sialic sialic JJ cord-329844-w969lczb 384 19 acid acid NN cord-329844-w969lczb 384 20 glycan glycan NN cord-329844-w969lczb 384 21 , , , cord-329844-w969lczb 384 22 and and CC cord-329844-w969lczb 384 23 related related JJ cord-329844-w969lczb 384 24 compounds compound NNS cord-329844-w969lczb 384 25 by by IN cord-329844-w969lczb 384 26 non non JJ cord-329844-w969lczb 384 27 - - JJ cord-329844-w969lczb 384 28 covalent covalent JJ cord-329844-w969lczb 384 29 binding binding NN cord-329844-w969lczb 384 30 . . . cord-329844-w969lczb 385 1 Predicted predict VBN cord-329844-w969lczb 385 2 correctly correctly RB cord-329844-w969lczb 385 3 , , , cord-329844-w969lczb 385 4 these these DT cord-329844-w969lczb 385 5 would would MD cord-329844-w969lczb 385 6 represent represent VB cord-329844-w969lczb 385 7 the the DT cord-329844-w969lczb 385 8 true true JJ cord-329844-w969lczb 385 9 positives positive NNS cord-329844-w969lczb 385 10 , , , cord-329844-w969lczb 385 11 but but CC cord-329844-w969lczb 385 12 predicted predict VBD cord-329844-w969lczb 385 13 incorrectly incorrectly RB cord-329844-w969lczb 385 14 , , , cord-329844-w969lczb 385 15 they -PRON- PRP cord-329844-w969lczb 385 16 would would MD cord-329844-w969lczb 385 17 represent represent VB cord-329844-w969lczb 385 18 false false JJ cord-329844-w969lczb 385 19 negatives negative NNS cord-329844-w969lczb 385 20 . . . cord-329844-w969lczb 386 1 Such such JJ cord-329844-w969lczb 386 2 proteins protein NNS cord-329844-w969lczb 386 3 include include VBP cord-329844-w969lczb 386 4 various various JJ cord-329844-w969lczb 386 5 hemagglutinins hemagglutinin NNS cord-329844-w969lczb 386 6 such such JJ cord-329844-w969lczb 386 7 as as IN cord-329844-w969lczb 386 8 that that DT cord-329844-w969lczb 386 9 of of IN cord-329844-w969lczb 386 10 influenza influenza NN cord-329844-w969lczb 386 11 A a NN cord-329844-w969lczb 386 12 at at IN cord-329844-w969lczb 386 13 GenBank GenBank NNP cord-329844-w969lczb 386 14 CAA24291 CAA24291 NNP cord-329844-w969lczb 386 15 . . . cord-329844-w969lczb 387 1 Generally generally RB cord-329844-w969lczb 387 2 arbitrarily arbitrarily RB cord-329844-w969lczb 387 3 selected select VBN cord-329844-w969lczb 387 4 neuraminidases neuraminidase NNS cord-329844-w969lczb 387 5 and and CC cord-329844-w969lczb 387 6 hemagglutinins hemagglutinin NNS cord-329844-w969lczb 387 7 are be VBP cord-329844-w969lczb 387 8 true true JJ cord-329844-w969lczb 387 9 positives positive NNS cord-329844-w969lczb 387 10 but but CC cord-329844-w969lczb 387 11 the the DT cord-329844-w969lczb 387 12 above above JJ cord-329844-w969lczb 387 13 kind kind NN cord-329844-w969lczb 387 14 of of IN cord-329844-w969lczb 387 15 pattern pattern NN cord-329844-w969lczb 387 16 , , , cord-329844-w969lczb 387 17 a a DT cord-329844-w969lczb 387 18 segment segment NN cord-329844-w969lczb 387 19 of of IN cord-329844-w969lczb 387 20 approximately approximately RB cord-329844-w969lczb 387 21 9 9 CD cord-329844-w969lczb 387 22 - - SYM cord-329844-w969lczb 387 23 23 23 CD cord-329844-w969lczb 387 24 residues residue NNS cord-329844-w969lczb 387 25 with with IN cord-329844-w969lczb 387 26 a a DT cord-329844-w969lczb 387 27 score score NN cord-329844-w969lczb 387 28 exceeding exceed VBG cord-329844-w969lczb 387 29 100 100 CD cord-329844-w969lczb 387 30 and and CC cord-329844-w969lczb 387 31 centered center VBN cord-329844-w969lczb 387 32 on on IN cord-329844-w969lczb 387 33 tryptophan tryptophan NN cord-329844-w969lczb 387 34 with with IN cord-329844-w969lczb 387 35 the the DT cord-329844-w969lczb 387 36 peak peak NN cord-329844-w969lczb 387 37 score score NN cord-329844-w969lczb 387 38 , , , cord-329844-w969lczb 387 39 is be VBZ cord-329844-w969lczb 387 40 not not RB cord-329844-w969lczb 387 41 universal universal JJ cord-329844-w969lczb 387 42 . . . cord-329844-w969lczb 388 1 Sometimes sometimes RB cord-329844-w969lczb 388 2 it -PRON- PRP cord-329844-w969lczb 388 3 is be VBZ cord-329844-w969lczb 388 4 another another DT cord-329844-w969lczb 388 5 hydrophobic hydrophobic JJ cord-329844-w969lczb 388 6 residue residue NN cord-329844-w969lczb 388 7 . . . cord-329844-w969lczb 389 1 In in IN cord-329844-w969lczb 389 2 a a DT cord-329844-w969lczb 389 3 " " `` cord-329844-w969lczb 389 4 haemaglutinin haemaglutinin NNP cord-329844-w969lczb 389 5 repeat repeat NN cord-329844-w969lczb 389 6 - - HYPH cord-329844-w969lczb 389 7 containing contain VBG cord-329844-w969lczb 389 8 protein protein NN cord-329844-w969lczb 389 9 " " '' cord-329844-w969lczb 389 10 of of IN cord-329844-w969lczb 389 11 a a DT cord-329844-w969lczb 389 12 yet yet RB cord-329844-w969lczb 389 13 to to TO cord-329844-w969lczb 389 14 be be VB cord-329844-w969lczb 389 15 fully fully RB cord-329844-w969lczb 389 16 classified classify VBN cord-329844-w969lczb 389 17 micororganism micororganism NN cord-329844-w969lczb 389 18 Candidatus Candidatus NNP cord-329844-w969lczb 389 19 Kentron Kentron NNP cord-329844-w969lczb 389 20 a a DT cord-329844-w969lczb 389 21 tryptophan tryptophan NN cord-329844-w969lczb 389 22 ( ( -LRB- cord-329844-w969lczb 389 23 W w NN cord-329844-w969lczb 389 24 ) ) -RRB- cord-329844-w969lczb 389 25 with with IN cord-329844-w969lczb 389 26 a a DT cord-329844-w969lczb 389 27 score score NN cord-329844-w969lczb 389 28 of of IN cord-329844-w969lczb 389 29 118 118 CD cord-329844-w969lczb 389 30 is be VBZ cord-329844-w969lczb 389 31 slightly slightly RB cord-329844-w969lczb 389 32 displaced displace VBN cord-329844-w969lczb 389 33 from from IN cord-329844-w969lczb 389 34 the the DT cord-329844-w969lczb 389 35 central central JJ cord-329844-w969lczb 389 36 peak peak NN cord-329844-w969lczb 389 37 of of IN cord-329844-w969lczb 389 38 119 119 CD cord-329844-w969lczb 389 39 associated associate VBN cord-329844-w969lczb 389 40 with with IN cord-329844-w969lczb 389 41 a a DT cord-329844-w969lczb 389 42 run run NN cord-329844-w969lczb 389 43 of of IN cord-329844-w969lczb 389 44 three three CD cord-329844-w969lczb 389 45 glycines glycine NNS cord-329844-w969lczb 389 46 ( ( -LRB- cord-329844-w969lczb 389 47 G G NNP cord-329844-w969lczb 389 48 ) ) -RRB- cord-329844-w969lczb 389 49 . . . cord-329844-w969lczb 390 1 It -PRON- PRP cord-329844-w969lczb 390 2 is be VBZ cord-329844-w969lczb 390 3 two two CD cord-329844-w969lczb 390 4 glutamate glutamate NN cord-329844-w969lczb 390 5 residues residue NNS cord-329844-w969lczb 390 6 ( ( -LRB- cord-329844-w969lczb 390 7 E E NNP cord-329844-w969lczb 390 8 ) ) -RRB- cord-329844-w969lczb 390 9 , , , cord-329844-w969lczb 390 10 negatively negatively RB cord-329844-w969lczb 390 11 charged charge VBN cord-329844-w969lczb 390 12 that that WDT cord-329844-w969lczb 390 13 are be VBP cord-329844-w969lczb 390 14 in in IN cord-329844-w969lczb 390 15 the the DT cord-329844-w969lczb 390 16 vicinity vicinity NN cord-329844-w969lczb 390 17 in in IN cord-329844-w969lczb 390 18 the the DT cord-329844-w969lczb 390 19 sequence sequence NN cord-329844-w969lczb 390 20 that that WDT cord-329844-w969lczb 390 21 appear appear VBP cord-329844-w969lczb 390 22 to to TO cord-329844-w969lczb 390 23 perturb perturb VB cord-329844-w969lczb 390 24 the the DT cord-329844-w969lczb 390 25 usual usual JJ cord-329844-w969lczb 390 26 central central JJ cord-329844-w969lczb 390 27 role role NN cord-329844-w969lczb 390 28 of of IN cord-329844-w969lczb 390 29 tryptophan tryptophan NN cord-329844-w969lczb 390 30 . . . cord-329844-w969lczb 391 1 Similarly similarly RB cord-329844-w969lczb 391 2 , , , cord-329844-w969lczb 391 3 a a DT cord-329844-w969lczb 391 4 rat rat NN cord-329844-w969lczb 391 5 neuraminidase neuraminidase NN cord-329844-w969lczb 391 6 is be VBZ cord-329844-w969lczb 391 7 of of IN cord-329844-w969lczb 391 8 some some DT cord-329844-w969lczb 391 9 interest interest NN cord-329844-w969lczb 391 10 in in IN cord-329844-w969lczb 391 11 that that IN cord-329844-w969lczb 391 12 the the DT cord-329844-w969lczb 391 13 predicted predict VBN cord-329844-w969lczb 391 14 sequence sequence NN cord-329844-w969lczb 391 15 SLDHGHTW SLDHGHTW NNP cord-329844-w969lczb 391 16 surrounds surround VBZ cord-329844-w969lczb 391 17 the the DT cord-329844-w969lczb 391 18 glycine glycine NN cord-329844-w969lczb 391 19 ( ( -LRB- cord-329844-w969lczb 391 20 G G NNP cord-329844-w969lczb 391 21 ) ) -RRB- cord-329844-w969lczb 391 22 with with IN cord-329844-w969lczb 391 23 peak peak NN cord-329844-w969lczb 391 24 score score NN cord-329844-w969lczb 391 25 106 106 CD cord-329844-w969lczb 391 26 and and CC cord-329844-w969lczb 391 27 terminates terminate VBZ cord-329844-w969lczb 391 28 at at IN cord-329844-w969lczb 391 29 tryptophan tryptophan NN cord-329844-w969lczb 391 30 ( ( -LRB- cord-329844-w969lczb 391 31 W w NN cord-329844-w969lczb 391 32 ) ) -RRB- cord-329844-w969lczb 391 33 with with IN cord-329844-w969lczb 391 34 a a DT cord-329844-w969lczb 391 35 score score NN cord-329844-w969lczb 391 36 of of IN cord-329844-w969lczb 391 37 102 102 CD cord-329844-w969lczb 391 38 . . . cord-329844-w969lczb 392 1 The the DT cord-329844-w969lczb 392 2 tryptophan tryptophan NN cord-329844-w969lczb 392 3 is be VBZ cord-329844-w969lczb 392 4 , , , cord-329844-w969lczb 392 5 however however RB cord-329844-w969lczb 392 6 , , , cord-329844-w969lczb 392 7 immediately immediately RB cord-329844-w969lczb 392 8 followed follow VBD cord-329844-w969lczb 392 9 by by IN cord-329844-w969lczb 392 10 a a DT cord-329844-w969lczb 392 11 glutamate glutamate NN cord-329844-w969lczb 392 12 ( ( -LRB- cord-329844-w969lczb 392 13 E e NN cord-329844-w969lczb 392 14 ) ) -RRB- cord-329844-w969lczb 392 15 . . . cord-329844-w969lczb 393 1 The the DT cord-329844-w969lczb 393 2 significance significance NN cord-329844-w969lczb 393 3 of of IN cord-329844-w969lczb 393 4 the the DT cord-329844-w969lczb 393 5 above above JJ cord-329844-w969lczb 393 6 comments comment NNS cord-329844-w969lczb 393 7 is be VBZ cord-329844-w969lczb 393 8 as as IN cord-329844-w969lczb 393 9 follows follow VBZ cord-329844-w969lczb 393 10 . . . cord-329844-w969lczb 394 1 Of of IN cord-329844-w969lczb 394 2 the the DT cord-329844-w969lczb 394 3 amino amino NN cord-329844-w969lczb 394 4 acids acid NNS cord-329844-w969lczb 394 5 with with IN cord-329844-w969lczb 394 6 charged charge VBN cord-329844-w969lczb 394 7 sidechains sidechain NNS cord-329844-w969lczb 394 8 , , , cord-329844-w969lczb 394 9 only only RB cord-329844-w969lczb 394 10 aspartate aspartate NN cord-329844-w969lczb 394 11 ( ( -LRB- cord-329844-w969lczb 394 12 D D NNP cord-329844-w969lczb 394 13 ) ) -RRB- cord-329844-w969lczb 394 14 and and CC cord-329844-w969lczb 394 15 histidine histidine NN cord-329844-w969lczb 394 16 ( ( -LRB- cord-329844-w969lczb 394 17 H h NN cord-329844-w969lczb 394 18 ) ) -RRB- cord-329844-w969lczb 394 19 appear appear VBP cord-329844-w969lczb 394 20 to to TO cord-329844-w969lczb 394 21 favor favor VB cord-329844-w969lczb 394 22 such such JJ cord-329844-w969lczb 394 23 binding binding NN cord-329844-w969lczb 394 24 in in IN cord-329844-w969lczb 394 25 the the DT cord-329844-w969lczb 394 26 present present JJ cord-329844-w969lczb 394 27 author author NN cord-329844-w969lczb 394 28 's 's POS cord-329844-w969lczb 394 29 analysis analysis NN cord-329844-w969lczb 394 30 , , , cord-329844-w969lczb 394 31 while while IN cord-329844-w969lczb 394 32 glutamate glutamate NN cord-329844-w969lczb 394 33 ( ( -LRB- cord-329844-w969lczb 394 34 E e NN cord-329844-w969lczb 394 35 ) ) -RRB- cord-329844-w969lczb 394 36 arginine arginine NN cord-329844-w969lczb 394 37 ( ( -LRB- cord-329844-w969lczb 394 38 R r NN cord-329844-w969lczb 394 39 ) ) -RRB- cord-329844-w969lczb 394 40 , , , cord-329844-w969lczb 394 41 lysine lysine NN cord-329844-w969lczb 394 42 ( ( -LRB- cord-329844-w969lczb 394 43 K K NNP cord-329844-w969lczb 394 44 ) ) -RRB- cord-329844-w969lczb 394 45 have have VB cord-329844-w969lczb 394 46 zero zero CD cord-329844-w969lczb 394 47 valued value VBN cord-329844-w969lczb 394 48 parameters parameter NNS cord-329844-w969lczb 394 49 and and CC cord-329844-w969lczb 394 50 so so RB cord-329844-w969lczb 394 51 are be VBP cord-329844-w969lczb 394 52 contraindications contraindication NNS cord-329844-w969lczb 394 53 of of IN cord-329844-w969lczb 394 54 sialic sialic JJ cord-329844-w969lczb 394 55 acid acid NN cord-329844-w969lczb 394 56 or or CC cord-329844-w969lczb 394 57 sialic sialic JJ cord-329844-w969lczb 394 58 acid acid NN cord-329844-w969lczb 394 59 glycan glycan NN cord-329844-w969lczb 394 60 binding binding NN cord-329844-w969lczb 394 61 . . . cord-329844-w969lczb 395 1 However however RB cord-329844-w969lczb 395 2 , , , cord-329844-w969lczb 395 3 the the DT cord-329844-w969lczb 395 4 latter latter JJ cord-329844-w969lczb 395 5 three three CD cord-329844-w969lczb 395 6 charged charge VBN cord-329844-w969lczb 395 7 amino amino NN cord-329844-w969lczb 395 8 acid acid NN cord-329844-w969lczb 395 9 residue residue NN cord-329844-w969lczb 395 10 can can MD cord-329844-w969lczb 395 11 sometimes sometimes RB cord-329844-w969lczb 395 12 be be VB cord-329844-w969lczb 395 13 found find VBN cord-329844-w969lczb 395 14 in in IN cord-329844-w969lczb 395 15 scialic scialic JJ cord-329844-w969lczb 395 16 acid acid NN cord-329844-w969lczb 395 17 binding bind VBG cord-329844-w969lczb 395 18 sites site NNS cord-329844-w969lczb 395 19 and and CC cord-329844-w969lczb 395 20 in in IN cord-329844-w969lczb 395 21 sites site NNS cord-329844-w969lczb 395 22 predicted predict VBN cord-329844-w969lczb 395 23 as as IN cord-329844-w969lczb 395 24 such such JJ cord-329844-w969lczb 395 25 by by IN cord-329844-w969lczb 395 26 the the DT cord-329844-w969lczb 395 27 present present JJ cord-329844-w969lczb 395 28 method method NN cord-329844-w969lczb 395 29 . . . cord-329844-w969lczb 396 1 Indeed indeed RB cord-329844-w969lczb 396 2 , , , cord-329844-w969lczb 396 3 they -PRON- PRP cord-329844-w969lczb 396 4 are be VBP cord-329844-w969lczb 396 5 often often RB cord-329844-w969lczb 396 6 dominant dominant JJ cord-329844-w969lczb 396 7 features feature NNS cord-329844-w969lczb 396 8 of of IN cord-329844-w969lczb 396 9 residues residue NNS cord-329844-w969lczb 396 10 directly directly RB cord-329844-w969lczb 396 11 interacting interact VBG cord-329844-w969lczb 396 12 with with IN cord-329844-w969lczb 396 13 sialic sialic JJ cord-329844-w969lczb 396 14 acid acid NN cord-329844-w969lczb 396 15 . . . cord-329844-w969lczb 397 1 in in IN cord-329844-w969lczb 397 2 the the DT cord-329844-w969lczb 397 3 sialic sialic JJ cord-329844-w969lczb 397 4 acid acid NN cord-329844-w969lczb 397 5 binding bind VBG cord-329844-w969lczb 397 6 site site NN cord-329844-w969lczb 397 7 of of IN cord-329844-w969lczb 397 8 the the DT cord-329844-w969lczb 397 9 globular globular JJ cord-329844-w969lczb 397 10 head head NN cord-329844-w969lczb 397 11 region region NN cord-329844-w969lczb 397 12 of of IN cord-329844-w969lczb 397 13 the the DT cord-329844-w969lczb 397 14 Newcastle Newcastle NNP cord-329844-w969lczb 397 15 disease disease NN cord-329844-w969lczb 397 16 virus virus NN cord-329844-w969lczb 397 17 haemagluttinin haemagluttinin NNP cord-329844-w969lczb 397 18 a a DT cord-329844-w969lczb 397 19 glutamate glutamate NN cord-329844-w969lczb 397 20 ( ( -LRB- cord-329844-w969lczb 397 21 E E NNP cord-329844-w969lczb 397 22 ) ) -RRB- cord-329844-w969lczb 397 23 , , . cord-329844-w969lczb 398 1 three three CD cord-329844-w969lczb 398 2 arginine arginine NN cord-329844-w969lczb 398 3 residues residue NNS cord-329844-w969lczb 398 4 ( ( -LRB- cord-329844-w969lczb 398 5 R r NN cord-329844-w969lczb 398 6 ) ) -RRB- cord-329844-w969lczb 398 7 and and CC cord-329844-w969lczb 398 8 a a DT cord-329844-w969lczb 398 9 lysine lysine NN cord-329844-w969lczb 398 10 ( ( -LRB- cord-329844-w969lczb 398 11 K K NNP cord-329844-w969lczb 398 12 ) ) -RRB- cord-329844-w969lczb 398 13 are be VBP cord-329844-w969lczb 398 14 intimate intimate JJ cord-329844-w969lczb 398 15 contact contact NN cord-329844-w969lczb 398 16 with with IN cord-329844-w969lczb 398 17 sialic sialic JJ cord-329844-w969lczb 398 18 acid acid NN cord-329844-w969lczb 398 19 ligand ligand NN cord-329844-w969lczb 398 20 . . . cord-329844-w969lczb 399 1 A a DT cord-329844-w969lczb 399 2 difference difference NN cord-329844-w969lczb 399 3 is be VBZ cord-329844-w969lczb 399 4 that that IN cord-329844-w969lczb 399 5 these these DT cord-329844-w969lczb 399 6 residues residue NNS cord-329844-w969lczb 399 7 make make VBP cord-329844-w969lczb 399 8 intimate intimate JJ cord-329844-w969lczb 399 9 contact contact NN cord-329844-w969lczb 399 10 in in IN cord-329844-w969lczb 399 11 space space NN cord-329844-w969lczb 399 12 and and CC cord-329844-w969lczb 399 13 are be VBP cord-329844-w969lczb 399 14 not not RB cord-329844-w969lczb 399 15 together together RB cord-329844-w969lczb 399 16 in in IN cord-329844-w969lczb 399 17 a a DT cord-329844-w969lczb 399 18 one one CD cord-329844-w969lczb 399 19 or or CC cord-329844-w969lczb 399 20 very very RB cord-329844-w969lczb 399 21 few few JJ cord-329844-w969lczb 399 22 subsequences subsequence NNS cord-329844-w969lczb 399 23 . . . cord-329844-w969lczb 400 1 That that RB cord-329844-w969lczb 400 2 is is RB cord-329844-w969lczb 400 3 , , , cord-329844-w969lczb 400 4 they -PRON- PRP cord-329844-w969lczb 400 5 do do VBP cord-329844-w969lczb 400 6 not not RB cord-329844-w969lczb 400 7 necessarily necessarily RB cord-329844-w969lczb 400 8 constitute constitute VB cord-329844-w969lczb 400 9 a a DT cord-329844-w969lczb 400 10 sequence sequence NN cord-329844-w969lczb 400 11 motif motif NN cord-329844-w969lczb 400 12 . . . cord-329844-w969lczb 401 1 The the DT cord-329844-w969lczb 401 2 actual actual JJ cord-329844-w969lczb 401 3 extent extent NN cord-329844-w969lczb 401 4 of of IN cord-329844-w969lczb 401 5 any any DT cord-329844-w969lczb 401 6 counter counter JJ cord-329844-w969lczb 401 7 - - JJ cord-329844-w969lczb 401 8 predictive predictive JJ cord-329844-w969lczb 401 9 impact impact NN cord-329844-w969lczb 401 10 of of IN cord-329844-w969lczb 401 11 the the DT cord-329844-w969lczb 401 12 above above RB cord-329844-w969lczb 401 13 charged charge VBN cord-329844-w969lczb 401 14 residues residue NNS cord-329844-w969lczb 401 15 other other JJ cord-329844-w969lczb 401 16 than than IN cord-329844-w969lczb 401 17 aspartate aspartate NN cord-329844-w969lczb 401 18 ( ( -LRB- cord-329844-w969lczb 401 19 D D NNP cord-329844-w969lczb 401 20 ) ) -RRB- cord-329844-w969lczb 401 21 and and CC cord-329844-w969lczb 401 22 histidine histidine NN cord-329844-w969lczb 401 23 ( ( -LRB- cord-329844-w969lczb 401 24 H H NNP cord-329844-w969lczb 401 25 ) ) -RRB- cord-329844-w969lczb 401 26 , , , cord-329844-w969lczb 401 27 when when WRB cord-329844-w969lczb 401 28 they -PRON- PRP cord-329844-w969lczb 401 29 together together RB cord-329844-w969lczb 401 30 in in IN cord-329844-w969lczb 401 31 a a DT cord-329844-w969lczb 401 32 subsequence subsequence NN cord-329844-w969lczb 401 33 of of IN cord-329844-w969lczb 401 34 amino amino JJ cord-329844-w969lczb 401 35 acids acid NNS cord-329844-w969lczb 401 36 examined examine VBN cord-329844-w969lczb 401 37 by by IN cord-329844-w969lczb 401 38 the the DT cord-329844-w969lczb 401 39 present present JJ cord-329844-w969lczb 401 40 algorithm algorithm NN cord-329844-w969lczb 401 41 , , , cord-329844-w969lczb 401 42 can can MD cord-329844-w969lczb 401 43 be be VB cord-329844-w969lczb 401 44 seen see VBN cord-329844-w969lczb 401 45 in in IN cord-329844-w969lczb 401 46 false false JJ cord-329844-w969lczb 401 47 negatives negative NNS cord-329844-w969lczb 401 48 . . . cord-329844-w969lczb 402 1 The the DT cord-329844-w969lczb 402 2 neuraminidase neuraminidase NN cord-329844-w969lczb 402 3 of of IN cord-329844-w969lczb 402 4 the the DT cord-329844-w969lczb 402 5 plant plant NN cord-329844-w969lczb 402 6 Striga Striga NNP cord-329844-w969lczb 402 7 asiatica asiatica NN cord-329844-w969lczb 402 8 ( ( -LRB- cord-329844-w969lczb 402 9 Asian asian JJ cord-329844-w969lczb 402 10 witchweed witchweed NN cord-329844-w969lczb 402 11 ) ) -RRB- cord-329844-w969lczb 402 12 , , , cord-329844-w969lczb 402 13 was be VBD cord-329844-w969lczb 402 14 one one CD cord-329844-w969lczb 402 15 of of IN cord-329844-w969lczb 402 16 the the DT cord-329844-w969lczb 402 17 false false JJ cord-329844-w969lczb 402 18 negatives negative NNS cord-329844-w969lczb 402 19 : : : cord-329844-w969lczb 402 20 the the DT cord-329844-w969lczb 402 21 analogous analogous JJ cord-329844-w969lczb 402 22 region region NN cord-329844-w969lczb 402 23 to to IN cord-329844-w969lczb 402 24 many many JJ cord-329844-w969lczb 402 25 of of IN cord-329844-w969lczb 402 26 the the DT cord-329844-w969lczb 402 27 above above JJ cord-329844-w969lczb 402 28 , , , cord-329844-w969lczb 402 29 at at IN cord-329844-w969lczb 402 30 least least JJS cord-329844-w969lczb 402 31 in in IN cord-329844-w969lczb 402 32 the the DT cord-329844-w969lczb 402 33 sense sense NN cord-329844-w969lczb 402 34 of of IN cord-329844-w969lczb 402 35 surrounding surround VBG cord-329844-w969lczb 402 36 the the DT cord-329844-w969lczb 402 37 only only JJ cord-329844-w969lczb 402 38 tryptophan tryptophan NN cord-329844-w969lczb 402 39 ( ( -LRB- cord-329844-w969lczb 402 40 W W NNP cord-329844-w969lczb 402 41 ) ) -RRB- cord-329844-w969lczb 402 42 and and CC cord-329844-w969lczb 402 43 with with IN cord-329844-w969lczb 402 44 the the DT cord-329844-w969lczb 402 45 peak peak NN cord-329844-w969lczb 402 46 value value NN cord-329844-w969lczb 402 47 , , , cord-329844-w969lczb 402 48 is be VBZ cord-329844-w969lczb 402 49 EGAVDRWRGEANF EGAVDRWRGEANF NNP cord-329844-w969lczb 402 50 where where WRB cord-329844-w969lczb 402 51 the the DT cord-329844-w969lczb 402 52 tryptophan tryptophan NN cord-329844-w969lczb 402 53 ( ( -LRB- cord-329844-w969lczb 402 54 W W NNP cord-329844-w969lczb 402 55 ) ) -RRB- cord-329844-w969lczb 402 56 has have VBZ cord-329844-w969lczb 402 57 only only RB cord-329844-w969lczb 402 58 a a DT cord-329844-w969lczb 402 59 peak peak NN cord-329844-w969lczb 402 60 value value NN cord-329844-w969lczb 402 61 of of IN cord-329844-w969lczb 402 62 88 88 CD cord-329844-w969lczb 402 63 , , , cord-329844-w969lczb 402 64 and and CC cord-329844-w969lczb 402 65 has have VBZ cord-329844-w969lczb 402 66 an an DT cord-329844-w969lczb 402 67 arginine arginine NN cord-329844-w969lczb 402 68 ( ( -LRB- cord-329844-w969lczb 402 69 R r NN cord-329844-w969lczb 402 70 ) ) -RRB- cord-329844-w969lczb 402 71 , , , cord-329844-w969lczb 402 72 positively positively RB cord-329844-w969lczb 402 73 charged charge VBN cord-329844-w969lczb 402 74 , , , cord-329844-w969lczb 402 75 on on IN cord-329844-w969lczb 402 76 both both DT cord-329844-w969lczb 402 77 sides side NNS cord-329844-w969lczb 402 78 . . . cord-329844-w969lczb 403 1 The the DT cord-329844-w969lczb 403 2 other other JJ cord-329844-w969lczb 403 3 false false JJ cord-329844-w969lczb 403 4 negative negative JJ cord-329844-w969lczb 403 5 in in IN cord-329844-w969lczb 403 6 the the DT cord-329844-w969lczb 403 7 original original JJ cord-329844-w969lczb 403 8 study study NN cord-329844-w969lczb 403 9 was be VBD cord-329844-w969lczb 403 10 a a DT cord-329844-w969lczb 403 11 bacterial bacterial JJ cord-329844-w969lczb 403 12 ( ( -LRB- cord-329844-w969lczb 403 13 Chryseobacterium Chryseobacterium NNP cord-329844-w969lczb 403 14 ) ) -RRB- cord-329844-w969lczb 403 15 haemagluttinin haemagluttinin NNP cord-329844-w969lczb 403 16 with with IN cord-329844-w969lczb 403 17 the the DT cord-329844-w969lczb 403 18 peak peak NN cord-329844-w969lczb 403 19 value value NN cord-329844-w969lczb 403 20 of of IN cord-329844-w969lczb 403 21 93 93 CD cord-329844-w969lczb 403 22 at at IN cord-329844-w969lczb 403 23 a a DT cord-329844-w969lczb 403 24 tryptophan tryptophan NN cord-329844-w969lczb 403 25 , , , cord-329844-w969lczb 403 26 but but CC cord-329844-w969lczb 403 27 with with IN cord-329844-w969lczb 403 28 two two CD cord-329844-w969lczb 403 29 lysine lysine NN cord-329844-w969lczb 403 30 residues residue NNS cord-329844-w969lczb 403 31 ( ( -LRB- cord-329844-w969lczb 403 32 K K NNP cord-329844-w969lczb 403 33 ) ) -RRB- cord-329844-w969lczb 403 34 , , , cord-329844-w969lczb 403 35 also also RB cord-329844-w969lczb 403 36 positively positively RB cord-329844-w969lczb 403 37 charged charge VBN cord-329844-w969lczb 403 38 sidechains sidechain NNS cord-329844-w969lczb 403 39 , , , cord-329844-w969lczb 403 40 in in IN cord-329844-w969lczb 403 41 the the DT cord-329844-w969lczb 403 42 vicinity vicinity NN cord-329844-w969lczb 403 43 . . . cord-329844-w969lczb 404 1 Later later JJ cord-329844-w969lczb 404 2 studies study NNS cord-329844-w969lczb 404 3 also also RB cord-329844-w969lczb 404 4 noted note VBD cord-329844-w969lczb 404 5 that that IN cord-329844-w969lczb 404 6 N n NN cord-329844-w969lczb 404 7 - - HYPH cord-329844-w969lczb 404 8 acetyl acetyl NN cord-329844-w969lczb 404 9 neuraminic neuraminic JJ cord-329844-w969lczb 404 10 acid acid NN cord-329844-w969lczb 404 11 synthetase synthetase NNP cord-329844-w969lczb 404 12 NeuB NeuB NNP cord-329844-w969lczb 404 13 of of IN cord-329844-w969lczb 404 14 E. E. NNP cord-329844-w969lczb 404 15 coli coli NNS cord-329844-w969lczb 404 16 , , , cord-329844-w969lczb 404 17 which which WDT cord-329844-w969lczb 404 18 has have VBZ cord-329844-w969lczb 404 19 score score NN cord-329844-w969lczb 404 20 of of IN cord-329844-w969lczb 404 21 any any DT cord-329844-w969lczb 404 22 residue residue NN cord-329844-w969lczb 404 23 to to IN cord-329844-w969lczb 404 24 more more JJR cord-329844-w969lczb 404 25 than than IN cord-329844-w969lczb 404 26 100 100 CD cord-329844-w969lczb 404 27 . . . cord-329844-w969lczb 405 1 For for IN cord-329844-w969lczb 405 2 example example NN cord-329844-w969lczb 405 3 , , , cord-329844-w969lczb 405 4 in in IN cord-329844-w969lczb 405 5 the the DT cord-329844-w969lczb 405 6 case case NN cord-329844-w969lczb 405 7 of of IN cord-329844-w969lczb 405 8 the the DT cord-329844-w969lczb 405 9 witchweed witchweed NN cord-329844-w969lczb 405 10 neuraminidase neuraminidase NN cord-329844-w969lczb 405 11 , , , cord-329844-w969lczb 405 12 changing change VBG cord-329844-w969lczb 405 13 RWR RWR NNP cord-329844-w969lczb 405 14 to to IN cord-329844-w969lczb 405 15 SWS SWS NNP cord-329844-w969lczb 405 16 raised raise VBD cord-329844-w969lczb 405 17 the the DT cord-329844-w969lczb 405 18 peak peak NN cord-329844-w969lczb 405 19 value value NN cord-329844-w969lczb 405 20 at at IN cord-329844-w969lczb 405 21 the the DT cord-329844-w969lczb 405 22 tryptophan tryptophan NN cord-329844-w969lczb 405 23 to to IN cord-329844-w969lczb 405 24 99 99 CD cord-329844-w969lczb 405 25 , , , cord-329844-w969lczb 405 26 a a DT cord-329844-w969lczb 405 27 significant significant JJ cord-329844-w969lczb 405 28 increase increase NN cord-329844-w969lczb 405 29 but but CC cord-329844-w969lczb 405 30 still still RB cord-329844-w969lczb 405 31 not not RB cord-329844-w969lczb 405 32 exceeding exceed VBG cord-329844-w969lczb 405 33 100 100 CD cord-329844-w969lczb 405 34 . . . cord-329844-w969lczb 406 1 In in IN cord-329844-w969lczb 406 2 some some DT cord-329844-w969lczb 406 3 cases case NNS cord-329844-w969lczb 406 4 a a DT cord-329844-w969lczb 406 5 value value NN cord-329844-w969lczb 406 6 exceeding exceed VBG cord-329844-w969lczb 406 7 100 100 CD cord-329844-w969lczb 406 8 can can MD cord-329844-w969lczb 406 9 of of IN cord-329844-w969lczb 406 10 course course RB cord-329844-w969lczb 406 11 attained attain VBN cord-329844-w969lczb 406 12 . . . cord-329844-w969lczb 407 1 A a DT cord-329844-w969lczb 407 2 false false JJ cord-329844-w969lczb 407 3 negative negative NN cord-329844-w969lczb 407 4 also also RB cord-329844-w969lczb 407 5 found find VBN cord-329844-w969lczb 407 6 in in IN cord-329844-w969lczb 407 7 later later JJ cord-329844-w969lczb 407 8 studies study NNS cord-329844-w969lczb 407 9 investigating investigate VBG cord-329844-w969lczb 407 10 these these DT cord-329844-w969lczb 407 11 issues issue NNS cord-329844-w969lczb 407 12 was be VBD cord-329844-w969lczb 407 13 the the DT cord-329844-w969lczb 407 14 ox ox NN cord-329844-w969lczb 407 15 neuraminidase neuraminidase NN cord-329844-w969lczb 407 16 , , , cord-329844-w969lczb 407 17 with with IN cord-329844-w969lczb 407 18 the the DT cord-329844-w969lczb 407 19 subsequence subsequence NN cord-329844-w969lczb 407 20 DDHGVSWRYGGGVS DDHGVSWRYGGGVS NNP cord-329844-w969lczb 407 21 containing contain VBG cord-329844-w969lczb 407 22 the the DT cord-329844-w969lczb 407 23 tryptophan tryptophan NN cord-329844-w969lczb 407 24 ( ( -LRB- cord-329844-w969lczb 407 25 W w NN cord-329844-w969lczb 407 26 ) ) -RRB- cord-329844-w969lczb 407 27 with with IN cord-329844-w969lczb 407 28 peak peak NN cord-329844-w969lczb 407 29 value value NN cord-329844-w969lczb 407 30 96 96 CD cord-329844-w969lczb 407 31 . . . cord-329844-w969lczb 408 1 Changing change VBG cord-329844-w969lczb 408 2 to to IN cord-329844-w969lczb 408 3 an an DT cord-329844-w969lczb 408 4 serine serine NN cord-329844-w969lczb 408 5 ( ( -LRB- cord-329844-w969lczb 408 6 S s NN cord-329844-w969lczb 408 7 ) ) -RRB- cord-329844-w969lczb 408 8 the the DT cord-329844-w969lczb 408 9 arginine arginine NN cord-329844-w969lczb 408 10 ( ( -LRB- cord-329844-w969lczb 408 11 R r NN cord-329844-w969lczb 408 12 ) ) -RRB- cord-329844-w969lczb 409 1 adjacent adjacent JJ cord-329844-w969lczb 409 2 to to IN cord-329844-w969lczb 409 3 the the DT cord-329844-w969lczb 409 4 tryptophan tryptophan NN cord-329844-w969lczb 409 5 ( ( -LRB- cord-329844-w969lczb 409 6 W w NN cord-329844-w969lczb 409 7 ) ) -RRB- cord-329844-w969lczb 409 8 did do VBD cord-329844-w969lczb 409 9 have have VB cord-329844-w969lczb 409 10 an an DT cord-329844-w969lczb 409 11 effect effect NN cord-329844-w969lczb 409 12 , , , cord-329844-w969lczb 409 13 albeit albeit IN cord-329844-w969lczb 409 14 that that IN cord-329844-w969lczb 409 15 the the DT cord-329844-w969lczb 409 16 only only JJ cord-329844-w969lczb 409 17 change change NN cord-329844-w969lczb 409 18 was be VBD cord-329844-w969lczb 409 19 having have VBG cord-329844-w969lczb 409 20 the the DT cord-329844-w969lczb 409 21 tryptophan tryptophan NN cord-329844-w969lczb 409 22 as as IN cord-329844-w969lczb 409 23 the the DT cord-329844-w969lczb 409 24 only only JJ cord-329844-w969lczb 409 25 residue residue NN cord-329844-w969lczb 409 26 predicted predict VBD cord-329844-w969lczb 409 27 , , , cord-329844-w969lczb 409 28 with with IN cord-329844-w969lczb 409 29 a a DT cord-329844-w969lczb 409 30 marginal marginal JJ cord-329844-w969lczb 409 31 score score NN cord-329844-w969lczb 409 32 of of IN cord-329844-w969lczb 409 33 101 101 CD cord-329844-w969lczb 409 34 . . . cord-329844-w969lczb 410 1 Two two CD cord-329844-w969lczb 410 2 kinds kind NNS cord-329844-w969lczb 410 3 of of IN cord-329844-w969lczb 410 4 potential potential JJ cord-329844-w969lczb 410 5 true true JJ cord-329844-w969lczb 410 6 negative negative JJ cord-329844-w969lczb 410 7 or or CC cord-329844-w969lczb 410 8 false false JJ cord-329844-w969lczb 410 9 negative negative JJ cord-329844-w969lczb 410 10 were be VBD cord-329844-w969lczb 410 11 distinguished distinguish VBN cord-329844-w969lczb 410 12 in in IN cord-329844-w969lczb 410 13 the the DT cord-329844-w969lczb 410 14 study study NN cord-329844-w969lczb 410 15 . . . cord-329844-w969lczb 411 1 The the DT cord-329844-w969lczb 411 2 group group NN cord-329844-w969lczb 411 3 that that WDT cord-329844-w969lczb 411 4 appeared appear VBD cord-329844-w969lczb 411 5 to to TO cord-329844-w969lczb 411 6 do do VB cord-329844-w969lczb 411 7 particularly particularly RB cord-329844-w969lczb 411 8 well well RB cord-329844-w969lczb 411 9 at at IN cord-329844-w969lczb 411 10 predicting predict VBG cord-329844-w969lczb 411 11 those those DT cord-329844-w969lczb 411 12 proteins protein NNS cord-329844-w969lczb 411 13 that that WDT cord-329844-w969lczb 411 14 do do VBP cord-329844-w969lczb 411 15 not not RB cord-329844-w969lczb 411 16 binding bind VBG cord-329844-w969lczb 411 17 sialic sialic JJ cord-329844-w969lczb 411 18 acid acid NN cord-329844-w969lczb 411 19 or or CC cord-329844-w969lczb 411 20 sialic sialic JJ cord-329844-w969lczb 411 21 acid acid NN cord-329844-w969lczb 411 22 glycan glycan NN cord-329844-w969lczb 411 23 was be VBD cord-329844-w969lczb 411 24 , , , cord-329844-w969lczb 411 25 perhaps perhaps RB cord-329844-w969lczb 411 26 not not RB cord-329844-w969lczb 411 27 surprisingly surprisingly RB cord-329844-w969lczb 411 28 , , , cord-329844-w969lczb 411 29 group group NN cord-329844-w969lczb 411 30 B b NN cord-329844-w969lczb 411 31 , , , cord-329844-w969lczb 411 32 i.e. i.e. FW cord-329844-w969lczb 411 33 those those DT cord-329844-w969lczb 411 34 proteins protein NNS cord-329844-w969lczb 411 35 not not RB cord-329844-w969lczb 411 36 expected expect VBN cord-329844-w969lczb 411 37 to to TO cord-329844-w969lczb 411 38 bind bind VB cord-329844-w969lczb 411 39 any any DT cord-329844-w969lczb 411 40 kind kind NN cord-329844-w969lczb 411 41 of of IN cord-329844-w969lczb 411 42 sugars sugar NNS cord-329844-w969lczb 411 43 . . . cord-329844-w969lczb 412 1 Out out IN cord-329844-w969lczb 412 2 of of IN cord-329844-w969lczb 412 3 the the DT cord-329844-w969lczb 412 4 original original JJ cord-329844-w969lczb 412 5 sample sample NN cord-329844-w969lczb 412 6 of of IN cord-329844-w969lczb 412 7 10 10 CD cord-329844-w969lczb 412 8 proteins protein NNS cord-329844-w969lczb 412 9 not not RB cord-329844-w969lczb 412 10 expected expect VBN cord-329844-w969lczb 412 11 to to TO cord-329844-w969lczb 412 12 bind bind VB cord-329844-w969lczb 412 13 any any DT cord-329844-w969lczb 412 14 kinds kind NNS cord-329844-w969lczb 412 15 of of IN cord-329844-w969lczb 412 16 sugars sugar NNS cord-329844-w969lczb 412 17 significantly significantly RB cord-329844-w969lczb 412 18 , , , cord-329844-w969lczb 412 19 and and CC cord-329844-w969lczb 412 20 that that DT cord-329844-w969lczb 412 21 also also RB cord-329844-w969lczb 412 22 confirmed confirm VBD cord-329844-w969lczb 412 23 that that IN cord-329844-w969lczb 412 24 expectation expectation NN cord-329844-w969lczb 412 25 , , , cord-329844-w969lczb 412 26 i.e. i.e. FW cord-329844-w969lczb 412 27 true true JJ cord-329844-w969lczb 412 28 negatives negative NNS cord-329844-w969lczb 412 29 as as RB cord-329844-w969lczb 412 30 far far RB cord-329844-w969lczb 412 31 as as IN cord-329844-w969lczb 412 32 predicting predict VBG cord-329844-w969lczb 412 33 sialic sialic JJ cord-329844-w969lczb 412 34 acid acid NN cord-329844-w969lczb 412 35 binding binding NN cord-329844-w969lczb 412 36 is be VBZ cord-329844-w969lczb 412 37 concerned concern VBN cord-329844-w969lczb 412 38 , , , cord-329844-w969lczb 412 39 two two CD cord-329844-w969lczb 412 40 ( ( -LRB- cord-329844-w969lczb 412 41 i i NN cord-329844-w969lczb 412 42 ) ) -RRB- cord-329844-w969lczb 412 43 hemoglobin hemoglobin NN cord-329844-w969lczb 412 44 and and CC cord-329844-w969lczb 412 45 ( ( -LRB- cord-329844-w969lczb 412 46 ii ii NN cord-329844-w969lczb 412 47 ) ) -RRB- cord-329844-w969lczb 412 48 trypsin trypsin NN cord-329844-w969lczb 412 49 precursor precursor NN cord-329844-w969lczb 412 50 for for IN cord-329844-w969lczb 412 51 which which WDT cord-329844-w969lczb 412 52 the the DT cord-329844-w969lczb 412 53 prediction prediction NN cord-329844-w969lczb 412 54 plots plot VBZ cord-329844-w969lczb 412 55 for for IN cord-329844-w969lczb 412 56 which which WDT cord-329844-w969lczb 412 57 are be VBP cord-329844-w969lczb 412 58 shown show VBN cord-329844-w969lczb 412 59 in in IN cord-329844-w969lczb 412 60 Fig Fig NNP cord-329844-w969lczb 412 61 . . . cord-329844-w969lczb 413 1 4 4 LS cord-329844-w969lczb 413 2 . . . cord-329844-w969lczb 414 1 The the DT cord-329844-w969lczb 414 2 others other NNS cord-329844-w969lczb 414 3 not not RB cord-329844-w969lczb 414 4 shown show VBN cord-329844-w969lczb 414 5 are be VBP cord-329844-w969lczb 414 6 mostly mostly RB cord-329844-w969lczb 414 7 quite quite RB cord-329844-w969lczb 414 8 large large JJ cord-329844-w969lczb 414 9 proteins protein NNS cord-329844-w969lczb 414 10 containing contain VBG cord-329844-w969lczb 414 11 more more JJR cord-329844-w969lczb 414 12 than than IN cord-329844-w969lczb 414 13 5 5 CD cord-329844-w969lczb 414 14 tryptophan tryptophan NN cord-329844-w969lczb 414 15 residues residue NNS cord-329844-w969lczb 414 16 ( ( -LRB- cord-329844-w969lczb 414 17 W w NN cord-329844-w969lczb 414 18 ) ) -RRB- cord-329844-w969lczb 414 19 sites site NNS cord-329844-w969lczb 414 20 , , , cord-329844-w969lczb 414 21 for for IN cord-329844-w969lczb 414 22 which which WDT cord-329844-w969lczb 414 23 the the DT cord-329844-w969lczb 414 24 method method NN cord-329844-w969lczb 414 25 still still RB cord-329844-w969lczb 414 26 correctly correctly RB cord-329844-w969lczb 414 27 predicted predict VBN cord-329844-w969lczb 414 28 as as IN cord-329844-w969lczb 414 29 non non JJ cord-329844-w969lczb 414 30 - - JJ cord-329844-w969lczb 414 31 sialic sialic JJ cord-329844-w969lczb 414 32 - - HYPH cord-329844-w969lczb 414 33 acid acid NN cord-329844-w969lczb 414 34 binders binder NNS cord-329844-w969lczb 414 35 , , , cord-329844-w969lczb 414 36 and and CC cord-329844-w969lczb 414 37 so so RB cord-329844-w969lczb 414 38 worthy worthy JJ cord-329844-w969lczb 414 39 of of IN cord-329844-w969lczb 414 40 some some DT cord-329844-w969lczb 414 41 comments comment NNS cord-329844-w969lczb 414 42 . . . cord-329844-w969lczb 415 1 They -PRON- PRP cord-329844-w969lczb 415 2 included include VBD cord-329844-w969lczb 415 3 ( ( -LRB- cord-329844-w969lczb 415 4 iii iii NN cord-329844-w969lczb 415 5 ) ) -RRB- cord-329844-w969lczb 415 6 human human JJ cord-329844-w969lczb 415 7 ubiquitin ubiquitin NN cord-329844-w969lczb 415 8 C C NNP cord-329844-w969lczb 415 9 of of IN cord-329844-w969lczb 415 10 685 685 CD cord-329844-w969lczb 415 11 residues residue NNS cord-329844-w969lczb 415 12 and and CC cord-329844-w969lczb 415 13 no no DT cord-329844-w969lczb 415 14 tryptophans tryptophan NNS cord-329844-w969lczb 415 15 ( ( -LRB- cord-329844-w969lczb 415 16 W W NNP cord-329844-w969lczb 415 17 ) ) -RRB- cord-329844-w969lczb 415 18 and and CC cord-329844-w969lczb 415 19 no no DT cord-329844-w969lczb 415 20 residue residue NN cord-329844-w969lczb 415 21 score score NN cord-329844-w969lczb 415 22 exceeding exceed VBG cord-329844-w969lczb 415 23 56 56 CD cord-329844-w969lczb 415 24 , , , cord-329844-w969lczb 415 25 in in IN cord-329844-w969lczb 415 26 contrast contrast NN cord-329844-w969lczb 415 27 to to IN cord-329844-w969lczb 415 28 ( ( -LRB- cord-329844-w969lczb 415 29 iv iv LS cord-329844-w969lczb 415 30 ) ) -RRB- cord-329844-w969lczb 415 31 human human JJ cord-329844-w969lczb 415 32 progesterone progesterone NN cord-329844-w969lczb 415 33 receptor receptor NN cord-329844-w969lczb 415 34 of of IN cord-329844-w969lczb 415 35 933 933 CD cord-329844-w969lczb 415 36 residues residue NNS cord-329844-w969lczb 415 37 of of IN cord-329844-w969lczb 415 38 which which WDT cord-329844-w969lczb 416 1 6 6 CD cord-329844-w969lczb 416 2 were be VBD cord-329844-w969lczb 416 3 tryptophan tryptophan NN cord-329844-w969lczb 416 4 but but CC cord-329844-w969lczb 416 5 none none NN cord-329844-w969lczb 416 6 of of IN cord-329844-w969lczb 416 7 which which WDT cord-329844-w969lczb 416 8 exceeded exceed VBD cord-329844-w969lczb 416 9 100 100 CD cord-329844-w969lczb 417 1 ( ( -LRB- cord-329844-w969lczb 417 2 one one PRP cord-329844-w969lczb 417 3 had have VBD cord-329844-w969lczb 417 4 the the DT cord-329844-w969lczb 417 5 highest high JJS cord-329844-w969lczb 417 6 score score NN cord-329844-w969lczb 417 7 of of IN cord-329844-w969lczb 417 8 95 95 CD cord-329844-w969lczb 417 9 ) ) -RRB- cord-329844-w969lczb 417 10 . . . cord-329844-w969lczb 418 1 The the DT cord-329844-w969lczb 418 2 remaining remain VBG cord-329844-w969lczb 418 3 true true JJ cord-329844-w969lczb 418 4 negative negative JJ cord-329844-w969lczb 418 5 cases case NNS cord-329844-w969lczb 418 6 are be VBP cord-329844-w969lczb 418 7 ( ( -LRB- cord-329844-w969lczb 418 8 v v LS cord-329844-w969lczb 418 9 ) ) -RRB- cord-329844-w969lczb 418 10 fatty fatty JJ cord-329844-w969lczb 418 11 acid acid NN cord-329844-w969lczb 418 12 oxidation oxidation NN cord-329844-w969lczb 418 13 complex complex NN cord-329844-w969lczb 419 1 subunit subunit NNP cord-329844-w969lczb 419 2 alpha alpha NN cord-329844-w969lczb 419 3 FadB FadB NNP cord-329844-w969lczb 419 4 of of IN cord-329844-w969lczb 419 5 Acinetobacter Acinetobacter NNP cord-329844-w969lczb 419 6 calcoaceticus calcoaceticus NNP cord-329844-w969lczb 419 7 of of IN cord-329844-w969lczb 419 8 a a DT cord-329844-w969lczb 419 9 substantial substantial JJ cord-329844-w969lczb 419 10 717 717 CD cord-329844-w969lczb 419 11 residues residue NNS cord-329844-w969lczb 419 12 , , , cord-329844-w969lczb 419 13 ( ( -LRB- cord-329844-w969lczb 419 14 vi vi NNP cord-329844-w969lczb 419 15 ) ) -RRB- cord-329844-w969lczb 419 16 the the DT cord-329844-w969lczb 419 17 mitochondrial mitochondrial NN cord-329844-w969lczb 419 18 NADH NADH NNP cord-329844-w969lczb 419 19 - - HYPH cord-329844-w969lczb 419 20 ubiquinone ubiquinone NN cord-329844-w969lczb 419 21 oxidoreductase oxidoreductase NNP cord-329844-w969lczb 419 22 75 75 CD cord-329844-w969lczb 419 23 kDa kDa NNP cord-329844-w969lczb 419 24 subunit subunit NN cord-329844-w969lczb 419 25 of of IN cord-329844-w969lczb 419 26 the the DT cord-329844-w969lczb 419 27 camel camel NN cord-329844-w969lczb 419 28 , , , cord-329844-w969lczb 419 29 which which WDT cord-329844-w969lczb 419 30 comprised comprise VBD cord-329844-w969lczb 419 31 a a DT cord-329844-w969lczb 419 32 substantial substantial JJ cord-329844-w969lczb 419 33 733 733 CD cord-329844-w969lczb 419 34 residues residue NNS cord-329844-w969lczb 419 35 but but CC cord-329844-w969lczb 419 36 did do VBD cord-329844-w969lczb 419 37 notably notably RB cord-329844-w969lczb 419 38 not not RB cord-329844-w969lczb 419 39 exceed exceed VB cord-329844-w969lczb 419 40 a a DT cord-329844-w969lczb 419 41 score score NN cord-329844-w969lczb 419 42 of of IN cord-329844-w969lczb 419 43 77 77 CD cord-329844-w969lczb 419 44 for for IN cord-329844-w969lczb 419 45 any any DT cord-329844-w969lczb 419 46 residue residue NN cord-329844-w969lczb 419 47 , , , cord-329844-w969lczb 419 48 ( ( -LRB- cord-329844-w969lczb 419 49 vii vii NN cord-329844-w969lczb 419 50 ) ) -RRB- cord-329844-w969lczb 419 51 human human JJ cord-329844-w969lczb 419 52 cytochrome cytochrome NN cord-329844-w969lczb 419 53 C C NNP cord-329844-w969lczb 419 54 with with IN cord-329844-w969lczb 419 55 a a DT cord-329844-w969lczb 419 56 maximum maximum JJ cord-329844-w969lczb 419 57 score score NN cord-329844-w969lczb 419 58 of of IN cord-329844-w969lczb 419 59 87 87 CD cord-329844-w969lczb 419 60 for for IN cord-329844-w969lczb 419 61 the the DT cord-329844-w969lczb 419 62 second second JJ cord-329844-w969lczb 419 63 tyrosine tyrosine NN cord-329844-w969lczb 419 64 ( ( -LRB- cord-329844-w969lczb 419 65 Y Y NNP cord-329844-w969lczb 419 66 ) ) -RRB- cord-329844-w969lczb 419 67 in in IN cord-329844-w969lczb 419 68 TGQAPGYSYTATAANKN TGQAPGYSYTATAANKN NNP cord-329844-w969lczb 419 69 , , , cord-329844-w969lczb 419 70 and and CC cord-329844-w969lczb 419 71 ( ( -LRB- cord-329844-w969lczb 419 72 viii viii NNP cord-329844-w969lczb 419 73 ) ) -RRB- cord-329844-w969lczb 419 74 alcohol alcohol NN cord-329844-w969lczb 419 75 dehydrogenase dehydrogenase NN cord-329844-w969lczb 419 76 ( ( -LRB- cord-329844-w969lczb 419 77 human human NN cord-329844-w969lczb 419 78 , , , cord-329844-w969lczb 419 79 1A 1a LS cord-329844-w969lczb 419 80 ) ) -RRB- cord-329844-w969lczb 419 81 that that WDT cord-329844-w969lczb 419 82 did do VBD cord-329844-w969lczb 419 83 not not RB cord-329844-w969lczb 419 84 exceed exceed VB cord-329844-w969lczb 419 85 a a DT cord-329844-w969lczb 419 86 score score NN cord-329844-w969lczb 419 87 of of IN cord-329844-w969lczb 419 88 81 81 CD cord-329844-w969lczb 419 89 for for IN cord-329844-w969lczb 419 90 any any DT cord-329844-w969lczb 419 91 residue residue NN cord-329844-w969lczb 419 92 despite despite IN cord-329844-w969lczb 419 93 the the DT cord-329844-w969lczb 419 94 " " `` cord-329844-w969lczb 419 95 concern concern NN cord-329844-w969lczb 419 96 " " '' cord-329844-w969lczb 419 97 that that IN cord-329844-w969lczb 419 98 ethanol ethanol NN cord-329844-w969lczb 419 99 having have VBG cord-329844-w969lczb 419 100 basic basic JJ cord-329844-w969lczb 419 101 sugar sugar NN cord-329844-w969lczb 419 102 - - HYPH cord-329844-w969lczb 419 103 like like JJ cord-329844-w969lczb 419 104 features feature NNS cord-329844-w969lczb 420 1 and and CC cord-329844-w969lczb 420 2 so so RB cord-329844-w969lczb 420 3 could could MD cord-329844-w969lczb 420 4 , , , cord-329844-w969lczb 420 5 a a FW cord-329844-w969lczb 420 6 priori priori FW cord-329844-w969lczb 420 7 , , , cord-329844-w969lczb 420 8 be be VB cord-329844-w969lczb 420 9 marginal marginal JJ cord-329844-w969lczb 420 10 . . . cord-329844-w969lczb 421 1 Perhaps perhaps RB cord-329844-w969lczb 421 2 unfairly unfairly RB cord-329844-w969lczb 421 3 included include VBN cord-329844-w969lczb 421 4 as as IN cord-329844-w969lczb 421 5 rather rather RB cord-329844-w969lczb 421 6 small small JJ cord-329844-w969lczb 421 7 , , , cord-329844-w969lczb 421 8 ( ( -LRB- cord-329844-w969lczb 421 9 ix ix NN cord-329844-w969lczb 421 10 ) ) -RRB- cord-329844-w969lczb 421 11 proinsulin proinsulin NNP cord-329844-w969lczb 421 12 nonetheless nonetheless RB cord-329844-w969lczb 421 13 does do VBZ cord-329844-w969lczb 421 14 contain contain VB cord-329844-w969lczb 421 15 a a DT cord-329844-w969lczb 421 16 tryptophan tryptophan NN cord-329844-w969lczb 421 17 ( ( -LRB- cord-329844-w969lczb 421 18 W w NN cord-329844-w969lczb 421 19 ) ) -RRB- cord-329844-w969lczb 421 20 which which WDT cord-329844-w969lczb 421 21 correctly correctly RB cord-329844-w969lczb 421 22 did do VBD cord-329844-w969lczb 421 23 not not RB cord-329844-w969lczb 421 24 exceed exceed VB cord-329844-w969lczb 421 25 100 100 CD cord-329844-w969lczb 421 26 and and CC cord-329844-w969lczb 421 27 indeed indeed RB cord-329844-w969lczb 421 28 only only RB cord-329844-w969lczb 421 29 had have VBD cord-329844-w969lczb 421 30 a a DT cord-329844-w969lczb 421 31 score score NN cord-329844-w969lczb 421 32 of of IN cord-329844-w969lczb 421 33 72 72 CD cord-329844-w969lczb 421 34 in in IN cord-329844-w969lczb 421 35 LLALLALWGPDPAAA LLALLALWGPDPAAA NNP cord-329844-w969lczb 421 36 ; ; : cord-329844-w969lczb 421 37 the the DT cord-329844-w969lczb 421 38 phenylalanine phenylalanine NN cord-329844-w969lczb 421 39 ( ( -LRB- cord-329844-w969lczb 421 40 F F NNP cord-329844-w969lczb 421 41 ) ) -RRB- cord-329844-w969lczb 421 42 in in IN cord-329844-w969lczb 421 43 GPDPAAAFVNQHLCG GPDPAAAFVNQHLCG NNP cord-329844-w969lczb 421 44 had have VBD cord-329844-w969lczb 421 45 a a DT cord-329844-w969lczb 421 46 highest high JJS cord-329844-w969lczb 421 47 score score NN cord-329844-w969lczb 421 48 of of IN cord-329844-w969lczb 421 49 81 81 CD cord-329844-w969lczb 421 50 in in IN cord-329844-w969lczb 421 51 the the DT cord-329844-w969lczb 421 52 sequence sequence NN cord-329844-w969lczb 421 53 . . . cord-329844-w969lczb 422 1 In in IN cord-329844-w969lczb 422 2 the the DT cord-329844-w969lczb 422 3 initial initial JJ cord-329844-w969lczb 422 4 study study NN cord-329844-w969lczb 422 5 , , , cord-329844-w969lczb 422 6 the the DT cord-329844-w969lczb 422 7 case case NN cord-329844-w969lczb 422 8 most most RBS cord-329844-w969lczb 422 9 closely closely RB cord-329844-w969lczb 422 10 approaching approach VBG cord-329844-w969lczb 422 11 a a DT cord-329844-w969lczb 422 12 false false JJ cord-329844-w969lczb 422 13 positive positive JJ cord-329844-w969lczb 422 14 in in IN cord-329844-w969lczb 422 15 this this DT cord-329844-w969lczb 422 16 group group NN cord-329844-w969lczb 422 17 was be VBD cord-329844-w969lczb 423 1 ( ( -LRB- cord-329844-w969lczb 423 2 x x LS cord-329844-w969lczb 423 3 ) ) -RRB- cord-329844-w969lczb 423 4 human human JJ cord-329844-w969lczb 423 5 prothrombin prothrombin NN cord-329844-w969lczb 423 6 with with IN cord-329844-w969lczb 423 7 a a DT cord-329844-w969lczb 423 8 substantial substantial JJ cord-329844-w969lczb 423 9 number number NN cord-329844-w969lczb 423 10 of of IN cord-329844-w969lczb 423 11 622 622 CD cord-329844-w969lczb 423 12 residues residue NNS cord-329844-w969lczb 423 13 , , , cord-329844-w969lczb 423 14 there there EX cord-329844-w969lczb 423 15 was be VBD cord-329844-w969lczb 423 16 only only RB cord-329844-w969lczb 423 17 one one CD cord-329844-w969lczb 423 18 residue residue NN cord-329844-w969lczb 423 19 , , , cord-329844-w969lczb 423 20 glycine glycine NN cord-329844-w969lczb 423 21 ( ( -LRB- cord-329844-w969lczb 423 22 G G NNP cord-329844-w969lczb 423 23 ) ) -RRB- cord-329844-w969lczb 423 24 , , , cord-329844-w969lczb 423 25 that that WDT cord-329844-w969lczb 423 26 reached reach VBD cord-329844-w969lczb 423 27 a a DT cord-329844-w969lczb 423 28 score score NN cord-329844-w969lczb 423 29 of of IN cord-329844-w969lczb 423 30 100 100 CD cord-329844-w969lczb 423 31 , , , cord-329844-w969lczb 423 32 and and CC cord-329844-w969lczb 423 33 a a DT cord-329844-w969lczb 423 34 residue residue NN cord-329844-w969lczb 423 35 score score NN cord-329844-w969lczb 423 36 should should MD cord-329844-w969lczb 423 37 exceed exceed VB cord-329844-w969lczb 423 38 100 100 CD cord-329844-w969lczb 423 39 to to TO cord-329844-w969lczb 423 40 classify classify VB cord-329844-w969lczb 423 41 the the DT cord-329844-w969lczb 423 42 whole whole JJ cord-329844-w969lczb 423 43 domain domain NN cord-329844-w969lczb 423 44 or or CC cord-329844-w969lczb 423 45 protein protein NN cord-329844-w969lczb 423 46 as as IN cord-329844-w969lczb 423 47 sialic sialic JJ cord-329844-w969lczb 423 48 acid acid NN cord-329844-w969lczb 423 49 binding binding NN cord-329844-w969lczb 423 50 . . . cord-329844-w969lczb 424 1 It -PRON- PRP cord-329844-w969lczb 424 2 is be VBZ cord-329844-w969lczb 424 3 possibly possibly RB cord-329844-w969lczb 424 4 best well RBS cord-329844-w969lczb 424 5 declared declare VBN cord-329844-w969lczb 424 6 as as IN cord-329844-w969lczb 424 7 an an DT cord-329844-w969lczb 424 8 example example NN cord-329844-w969lczb 424 9 of of IN cord-329844-w969lczb 424 10 a a DT cord-329844-w969lczb 424 11 marginal marginal JJ cord-329844-w969lczb 424 12 case case NN cord-329844-w969lczb 424 13 . . . cord-329844-w969lczb 425 1 Although although IN cord-329844-w969lczb 425 2 at at IN cord-329844-w969lczb 425 3 the the DT cord-329844-w969lczb 425 4 outset outset NN cord-329844-w969lczb 425 5 false false JJ cord-329844-w969lczb 425 6 positives positive NNS cord-329844-w969lczb 425 7 were be VBD cord-329844-w969lczb 425 8 expected expect VBN cord-329844-w969lczb 425 9 to to TO cord-329844-w969lczb 425 10 appear appear VB cord-329844-w969lczb 425 11 in in IN cord-329844-w969lczb 425 12 this this DT cord-329844-w969lczb 425 13 non non JJ cord-329844-w969lczb 425 14 - - JJ cord-329844-w969lczb 425 15 sugar sugar NN cord-329844-w969lczb 425 16 - - HYPH cord-329844-w969lczb 425 17 binding bind VBG cord-329844-w969lczb 425 18 group group NN cord-329844-w969lczb 425 19 groups group NNS cord-329844-w969lczb 425 20 as as IN cord-329844-w969lczb 425 21 the the DT cord-329844-w969lczb 425 22 sample sample NN cord-329844-w969lczb 425 23 is be VBZ cord-329844-w969lczb 425 24 increased increase VBN cord-329844-w969lczb 425 25 , , , cord-329844-w969lczb 425 26 not not RB cord-329844-w969lczb 425 27 least least JJS cord-329844-w969lczb 425 28 because because IN cord-329844-w969lczb 425 29 of of IN cord-329844-w969lczb 425 30 the the DT cord-329844-w969lczb 425 31 preliminary preliminary JJ cord-329844-w969lczb 425 32 nature nature NN cord-329844-w969lczb 425 33 of of IN cord-329844-w969lczb 425 34 the the DT cord-329844-w969lczb 425 35 method method NN cord-329844-w969lczb 425 36 . . . cord-329844-w969lczb 426 1 Human human JJ cord-329844-w969lczb 426 2 angiotensin angiotensin NN cord-329844-w969lczb 426 3 converting convert VBG cord-329844-w969lczb 426 4 enzyme enzyme NN cord-329844-w969lczb 426 5 type type NN cord-329844-w969lczb 426 6 2 2 CD cord-329844-w969lczb 426 7 ( ( -LRB- cord-329844-w969lczb 426 8 ACE2 ACE2 NNP cord-329844-w969lczb 426 9 ) ) -RRB- cord-329844-w969lczb 426 10 was be VBD cord-329844-w969lczb 426 11 the the DT cord-329844-w969lczb 426 12 first first JJ cord-329844-w969lczb 426 13 exception exception NN cord-329844-w969lczb 426 14 found find VBN cord-329844-w969lczb 426 15 and and CC cord-329844-w969lczb 426 16 it -PRON- PRP cord-329844-w969lczb 426 17 is be VBZ cord-329844-w969lczb 426 18 a a DT cord-329844-w969lczb 426 19 significant significant JJ cord-329844-w969lczb 426 20 exception exception NN cord-329844-w969lczb 426 21 in in IN cord-329844-w969lczb 426 22 that that IN cord-329844-w969lczb 426 23 it -PRON- PRP cord-329844-w969lczb 426 24 had have VBD cord-329844-w969lczb 426 25 two two CD cord-329844-w969lczb 426 26 substantial substantial JJ cord-329844-w969lczb 426 27 regions region NNS cord-329844-w969lczb 426 28 198 198 CD cord-329844-w969lczb 426 29 - - HYPH cord-329844-w969lczb 426 30 276 276 CD cord-329844-w969lczb 426 31 and and CC cord-329844-w969lczb 426 32 599 599 CD cord-329844-w969lczb 426 33 - - SYM cord-329844-w969lczb 426 34 610 610 CD cord-329844-w969lczb 427 1 both both DT cord-329844-w969lczb 427 2 exceeding exceed VBG cord-329844-w969lczb 427 3 scores score NNS cord-329844-w969lczb 427 4 of of IN cord-329844-w969lczb 427 5 100 100 CD cord-329844-w969lczb 427 6 throughout throughout IN cord-329844-w969lczb 427 7 and and CC cord-329844-w969lczb 427 8 peaking peak VBG cord-329844-w969lczb 427 9 at at IN cord-329844-w969lczb 427 10 substantial substantial JJ cord-329844-w969lczb 427 11 scores score NNS cord-329844-w969lczb 427 12 of of IN cord-329844-w969lczb 427 13 112 112 CD cord-329844-w969lczb 427 14 . . . cord-329844-w969lczb 428 1 This this DT cord-329844-w969lczb 428 2 group group NN cord-329844-w969lczb 428 3 is be VBZ cord-329844-w969lczb 428 4 interesting interesting JJ cord-329844-w969lczb 428 5 in in IN cord-329844-w969lczb 428 6 that that IN cord-329844-w969lczb 428 7 persistently persistently RB cord-329844-w969lczb 428 8 predicting predict VBG cord-329844-w969lczb 428 9 these these DT cord-329844-w969lczb 428 10 as as IN cord-329844-w969lczb 428 11 false false JJ cord-329844-w969lczb 428 12 positives positive NNS cord-329844-w969lczb 428 13 might may MD cord-329844-w969lczb 428 14 incline incline VB cord-329844-w969lczb 428 15 a a DT cord-329844-w969lczb 428 16 researcher researcher NN cord-329844-w969lczb 428 17 to to TO cord-329844-w969lczb 428 18 abandon abandon VB cord-329844-w969lczb 428 19 specifically specifically RB cord-329844-w969lczb 428 20 predicting predict VBG cord-329844-w969lczb 428 21 sialic sialic JJ cord-329844-w969lczb 428 22 acid acid NN cord-329844-w969lczb 428 23 glycan glycan NN cord-329844-w969lczb 428 24 binding binding NN cord-329844-w969lczb 428 25 and and CC cord-329844-w969lczb 428 26 instead instead RB cord-329844-w969lczb 428 27 consider consider VB cord-329844-w969lczb 428 28 their -PRON- PRP$ cord-329844-w969lczb 428 29 method method NN cord-329844-w969lczb 428 30 as as RB cord-329844-w969lczb 428 31 better well RBR cord-329844-w969lczb 428 32 positioned position VBN cord-329844-w969lczb 428 33 to to TO cord-329844-w969lczb 428 34 predict predict VB cord-329844-w969lczb 428 35 sugar sugar NN cord-329844-w969lczb 428 36 binding bind VBG cord-329844-w969lczb 428 37 in in IN cord-329844-w969lczb 428 38 general general JJ cord-329844-w969lczb 428 39 , , , cord-329844-w969lczb 428 40 but but CC cord-329844-w969lczb 428 41 this this DT cord-329844-w969lczb 428 42 turned turn VBD cord-329844-w969lczb 428 43 out out RP cord-329844-w969lczb 428 44 not not RB cord-329844-w969lczb 428 45 to to TO cord-329844-w969lczb 428 46 be be VB cord-329844-w969lczb 428 47 the the DT cord-329844-w969lczb 428 48 case case NN cord-329844-w969lczb 428 49 . . . cord-329844-w969lczb 429 1 For for IN cord-329844-w969lczb 429 2 Group Group NNP cord-329844-w969lczb 429 3 C C NNP cord-329844-w969lczb 429 4 , , , cord-329844-w969lczb 429 5 i.e. i.e. FW cord-329844-w969lczb 429 6 those those DT cord-329844-w969lczb 429 7 sugar sugar NN cord-329844-w969lczb 429 8 - - HYPH cord-329844-w969lczb 429 9 binding bind VBG cord-329844-w969lczb 429 10 proteins protein NNS cord-329844-w969lczb 429 11 that that WDT cord-329844-w969lczb 429 12 are be VBP cord-329844-w969lczb 429 13 believed believe VBN cord-329844-w969lczb 429 14 to to TO cord-329844-w969lczb 429 15 bind bind VB cord-329844-w969lczb 429 16 sugars sugar NNS cord-329844-w969lczb 429 17 but but CC cord-329844-w969lczb 429 18 not not RB cord-329844-w969lczb 429 19 to to TO cord-329844-w969lczb 429 20 bind bind VB cord-329844-w969lczb 429 21 sialic sialic JJ cord-329844-w969lczb 429 22 acids acid NNS cord-329844-w969lczb 429 23 or or CC cord-329844-w969lczb 429 24 glycans glycan NNS cord-329844-w969lczb 429 25 containing contain VBG cord-329844-w969lczb 429 26 them -PRON- PRP cord-329844-w969lczb 429 27 , , , cord-329844-w969lczb 429 28 the the DT cord-329844-w969lczb 429 29 prediction prediction NN cord-329844-w969lczb 429 30 plots plot VBZ cord-329844-w969lczb 429 31 for for IN cord-329844-w969lczb 429 32 the the DT cord-329844-w969lczb 429 33 6 6 CD cord-329844-w969lczb 429 34 true true JJ cord-329844-w969lczb 429 35 negatives negative NNS cord-329844-w969lczb 429 36 are be VBP cord-329844-w969lczb 429 37 shown show VBN cord-329844-w969lczb 429 38 to to IN cord-329844-w969lczb 429 39 the the DT cord-329844-w969lczb 429 40 lower low JJR cord-329844-w969lczb 429 41 right right NN cord-329844-w969lczb 429 42 in in IN cord-329844-w969lczb 429 43 Fig Fig NNP cord-329844-w969lczb 429 44 . . . cord-329844-w969lczb 430 1 4 4 LS cord-329844-w969lczb 430 2 . . . cord-329844-w969lczb 431 1 Human human JJ cord-329844-w969lczb 431 2 α α NN cord-329844-w969lczb 431 3 - - HYPH cord-329844-w969lczb 431 4 amylase amylase NN cord-329844-w969lczb 431 5 , , , cord-329844-w969lczb 431 6 not not RB cord-329844-w969lczb 431 7 shown show VBN cord-329844-w969lczb 431 8 , , , cord-329844-w969lczb 431 9 was be VBD cord-329844-w969lczb 431 10 an an DT cord-329844-w969lczb 431 11 interesting interesting JJ cord-329844-w969lczb 431 12 false false JJ cord-329844-w969lczb 431 13 positive positive JJ cord-329844-w969lczb 431 14 with with IN cord-329844-w969lczb 431 15 subsequence subsequence NN cord-329844-w969lczb 431 16 of of IN cord-329844-w969lczb 431 17 residues residue NNS cord-329844-w969lczb 431 18 all all DT cord-329844-w969lczb 431 19 only only RB cord-329844-w969lczb 431 20 marginally marginally RB cord-329844-w969lczb 431 21 exceeding exceed VBG cord-329844-w969lczb 431 22 100 100 CD cord-329844-w969lczb 431 23 YSGWDFWGEGW YSGWDFWGEGW NNPS cord-329844-w969lczb 431 24 but but CC cord-329844-w969lczb 431 25 containing contain VBG cord-329844-w969lczb 431 26 three three CD cord-329844-w969lczb 431 27 tryptophans tryptophan NNS cord-329844-w969lczb 431 28 ( ( -LRB- cord-329844-w969lczb 431 29 W w NN cord-329844-w969lczb 431 30 ) ) -RRB- cord-329844-w969lczb 431 31 of of IN cord-329844-w969lczb 431 32 which which WDT cord-329844-w969lczb 431 33 the the DT cord-329844-w969lczb 431 34 first first JJ cord-329844-w969lczb 431 35 had have VBD cord-329844-w969lczb 431 36 the the DT cord-329844-w969lczb 431 37 highest high JJS cord-329844-w969lczb 431 38 score score NN cord-329844-w969lczb 431 39 of of IN cord-329844-w969lczb 431 40 103 103 CD cord-329844-w969lczb 431 41 . . . cord-329844-w969lczb 432 1 The the DT cord-329844-w969lczb 432 2 human human JJ cord-329844-w969lczb 432 3 lysozyme lysozyme NNS cord-329844-w969lczb 432 4 precursor precursor NN cord-329844-w969lczb 432 5 was be VBD cord-329844-w969lczb 432 6 also also RB cord-329844-w969lczb 432 7 a a DT cord-329844-w969lczb 432 8 false false JJ cord-329844-w969lczb 432 9 positive positive JJ cord-329844-w969lczb 432 10 , , , cord-329844-w969lczb 432 11 albeit albeit IN cord-329844-w969lczb 432 12 only only RB cord-329844-w969lczb 432 13 marginally marginally RB cord-329844-w969lczb 432 14 so so RB cord-329844-w969lczb 432 15 , , , cord-329844-w969lczb 432 16 with with IN cord-329844-w969lczb 432 17 one one CD cord-329844-w969lczb 432 18 sequence sequence NN cord-329844-w969lczb 432 19 KWESGYNTRA KWESGYNTRA NNP cord-329844-w969lczb 432 20 exceeding exceed VBG cord-329844-w969lczb 432 21 100 100 CD cord-329844-w969lczb 432 22 and and CC cord-329844-w969lczb 432 23 with with IN cord-329844-w969lczb 432 24 the the DT cord-329844-w969lczb 432 25 peak peak NN cord-329844-w969lczb 432 26 at at IN cord-329844-w969lczb 432 27 tyrosine tyrosine NN cord-329844-w969lczb 432 28 ( ( -LRB- cord-329844-w969lczb 432 29 Y Y NNP cord-329844-w969lczb 432 30 ) ) -RRB- cord-329844-w969lczb 432 31 with with IN cord-329844-w969lczb 432 32 a a DT cord-329844-w969lczb 432 33 score score NN cord-329844-w969lczb 432 34 of of IN cord-329844-w969lczb 432 35 103 103 CD cord-329844-w969lczb 432 36 . . . cord-329844-w969lczb 433 1 In in IN cord-329844-w969lczb 433 2 later later JJ cord-329844-w969lczb 433 3 studies study NNS cord-329844-w969lczb 433 4 examining examine VBG cord-329844-w969lczb 433 5 the the DT cord-329844-w969lczb 433 6 effect effect NN cord-329844-w969lczb 433 7 of of IN cord-329844-w969lczb 433 8 considering consider VBG cord-329844-w969lczb 433 9 weakly weakly RB cord-329844-w969lczb 433 10 homologous homologous JJ cord-329844-w969lczb 433 11 sequences sequence NNS cord-329844-w969lczb 433 12 , , , cord-329844-w969lczb 433 13 the the DT cord-329844-w969lczb 433 14 significantly significantly RB cord-329844-w969lczb 433 15 different different JJ cord-329844-w969lczb 433 16 hen hen NN cord-329844-w969lczb 433 17 lysozyme lysozyme NN cord-329844-w969lczb 433 18 precursor precursor NN cord-329844-w969lczb 433 19 is be VBZ cord-329844-w969lczb 433 20 interesting interesting JJ cord-329844-w969lczb 433 21 as as IN cord-329844-w969lczb 433 22 still still RB cord-329844-w969lczb 433 23 being be VBG cord-329844-w969lczb 433 24 a a DT cord-329844-w969lczb 433 25 false false JJ cord-329844-w969lczb 433 26 positive positive JJ cord-329844-w969lczb 433 27 but but CC cord-329844-w969lczb 433 28 representing represent VBG cord-329844-w969lczb 433 29 and and CC cord-329844-w969lczb 433 30 even even RB cord-329844-w969lczb 433 31 more more RBR cord-329844-w969lczb 433 32 marginal marginal JJ cord-329844-w969lczb 433 33 case case NN cord-329844-w969lczb 433 34 , , , cord-329844-w969lczb 433 35 having have VBG cord-329844-w969lczb 433 36 one one CD cord-329844-w969lczb 433 37 short short JJ cord-329844-w969lczb 433 38 subsequence subsequence NN cord-329844-w969lczb 433 39 with with IN cord-329844-w969lczb 433 40 residues residue NNS cord-329844-w969lczb 433 41 exceeding exceed VBG cord-329844-w969lczb 433 42 100 100 CD cord-329844-w969lczb 433 43 , , , cord-329844-w969lczb 433 44 namely namely RB cord-329844-w969lczb 433 45 WV WV NNP cord-329844-w969lczb 433 46 , , , cord-329844-w969lczb 433 47 with with IN cord-329844-w969lczb 433 48 tryptophan tryptophan NN cord-329844-w969lczb 433 49 ( ( -LRB- cord-329844-w969lczb 433 50 W w NN cord-329844-w969lczb 433 51 ) ) -RRB- cord-329844-w969lczb 433 52 with with IN cord-329844-w969lczb 433 53 final final JJ cord-329844-w969lczb 433 54 score score NN cord-329844-w969lczb 433 55 102 102 CD cord-329844-w969lczb 433 56 followed follow VBN cord-329844-w969lczb 433 57 by by IN cord-329844-w969lczb 433 58 valine valine NN cord-329844-w969lczb 433 59 ( ( -LRB- cord-329844-w969lczb 433 60 V v NN cord-329844-w969lczb 433 61 ) ) -RRB- cord-329844-w969lczb 433 62 with with IN cord-329844-w969lczb 433 63 final final JJ cord-329844-w969lczb 433 64 score score NN cord-329844-w969lczb 433 65 101 101 CD cord-329844-w969lczb 433 66 . . . cord-329844-w969lczb 434 1 While while IN cord-329844-w969lczb 434 2 there there EX cord-329844-w969lczb 434 3 are be VBP cord-329844-w969lczb 434 4 significant significant JJ cord-329844-w969lczb 434 5 amounts amount NNS cord-329844-w969lczb 434 6 of of IN cord-329844-w969lczb 434 7 sialic sialic JJ cord-329844-w969lczb 434 8 acids acid NNS cord-329844-w969lczb 434 9 in in IN cord-329844-w969lczb 434 10 hen hen NN cord-329844-w969lczb 434 11 egg egg NN cord-329844-w969lczb 434 12 white white JJ cord-329844-w969lczb 434 13 , , , cord-329844-w969lczb 434 14 the the DT cord-329844-w969lczb 434 15 author author NN cord-329844-w969lczb 434 16 is be VBZ cord-329844-w969lczb 434 17 not not RB cord-329844-w969lczb 434 18 aware aware JJ cord-329844-w969lczb 434 19 of of IN cord-329844-w969lczb 434 20 any any DT cord-329844-w969lczb 434 21 extract extract NN cord-329844-w969lczb 434 22 of of IN cord-329844-w969lczb 434 23 hen hen NNP cord-329844-w969lczb 434 24 egg egg NNP cord-329844-w969lczb 434 25 white white NNP cord-329844-w969lczb 434 26 lysozyme lysozyme NNS cord-329844-w969lczb 434 27 that that WDT cord-329844-w969lczb 434 28 has have VBZ cord-329844-w969lczb 434 29 these these DT cord-329844-w969lczb 434 30 bound bind VBN cord-329844-w969lczb 434 31 to to IN cord-329844-w969lczb 434 32 the the DT cord-329844-w969lczb 434 33 protein protein NN cord-329844-w969lczb 434 34 . . . cord-329844-w969lczb 435 1 Evidently evidently RB cord-329844-w969lczb 435 2 comparisons comparison NNS cord-329844-w969lczb 435 3 of of IN cord-329844-w969lczb 435 4 homologous homologous JJ cord-329844-w969lczb 435 5 proteins protein NNS cord-329844-w969lczb 435 6 might may MD cord-329844-w969lczb 435 7 be be VB cord-329844-w969lczb 435 8 helpful helpful JJ cord-329844-w969lczb 435 9 to to TO cord-329844-w969lczb 435 10 improve improve VB cord-329844-w969lczb 435 11 prediction prediction NN cord-329844-w969lczb 435 12 power power NN cord-329844-w969lczb 435 13 . . . cord-329844-w969lczb 436 1 Another another DT cord-329844-w969lczb 436 2 false false JJ cord-329844-w969lczb 436 3 positive positive NN cord-329844-w969lczb 436 4 is be VBZ cord-329844-w969lczb 436 5 the the DT cord-329844-w969lczb 436 6 human human JJ cord-329844-w969lczb 436 7 ATP ATP NNP cord-329844-w969lczb 436 8 - - HYPH cord-329844-w969lczb 436 9 dependent dependent JJ cord-329844-w969lczb 436 10 translocase translocase NN cord-329844-w969lczb 436 11 ABCB1 ABCB1 NNP cord-329844-w969lczb 436 12 isoform isoform NN cord-329844-w969lczb 436 13 2 2 CD cord-329844-w969lczb 436 14 which which WDT cord-329844-w969lczb 436 15 has have VBZ cord-329844-w969lczb 436 16 a a DT cord-329844-w969lczb 436 17 ribose ribose NN cord-329844-w969lczb 436 18 binding bind VBG cord-329844-w969lczb 436 19 site site NN cord-329844-w969lczb 436 20 has have VBZ cord-329844-w969lczb 436 21 a a DT cord-329844-w969lczb 436 22 considerable considerable JJ cord-329844-w969lczb 436 23 size size NN cord-329844-w969lczb 436 24 of of IN cord-329844-w969lczb 436 25 1,280 1,280 CD cord-329844-w969lczb 436 26 residues residue NNS cord-329844-w969lczb 436 27 yet yet RB cord-329844-w969lczb 436 28 with with IN cord-329844-w969lczb 436 29 just just RB cord-329844-w969lczb 436 30 one one CD cord-329844-w969lczb 436 31 subsequence subsequence NN cord-329844-w969lczb 436 32 , , , cord-329844-w969lczb 436 33 SYALAFWYGMMYFSYAGCF SYALAFWYGMMYFSYAGCF NNP cord-329844-w969lczb 436 34 , , , cord-329844-w969lczb 436 35 exceeding exceed VBG cord-329844-w969lczb 436 36 100 100 CD cord-329844-w969lczb 436 37 , , , cord-329844-w969lczb 436 38 and and CC cord-329844-w969lczb 436 39 has have VBZ cord-329844-w969lczb 436 40 the the DT cord-329844-w969lczb 436 41 peak peak NN cord-329844-w969lczb 436 42 of of IN cord-329844-w969lczb 436 43 107 107 CD cord-329844-w969lczb 436 44 at at IN cord-329844-w969lczb 436 45 the the DT cord-329844-w969lczb 436 46 tryptophan tryptophan NN cord-329844-w969lczb 436 47 ( ( -LRB- cord-329844-w969lczb 436 48 W W NNP cord-329844-w969lczb 436 49 ) ) -RRB- cord-329844-w969lczb 436 50 . . . cord-329844-w969lczb 437 1 For for IN cord-329844-w969lczb 437 2 such such JJ cord-329844-w969lczb 437 3 reasons reason NNS cord-329844-w969lczb 437 4 , , , cord-329844-w969lczb 437 5 one one PRP cord-329844-w969lczb 437 6 may may MD cord-329844-w969lczb 437 7 suspect suspect VB cord-329844-w969lczb 437 8 that that IN cord-329844-w969lczb 437 9 a a DT cord-329844-w969lczb 437 10 fairer fair JJR cord-329844-w969lczb 437 11 set set NN cord-329844-w969lczb 437 12 of of IN cord-329844-w969lczb 437 13 criteria criterion NNS cord-329844-w969lczb 437 14 for for IN cord-329844-w969lczb 437 15 assessing assess VBG cord-329844-w969lczb 437 16 predictive predictive JJ cord-329844-w969lczb 437 17 performance performance NN cord-329844-w969lczb 437 18 would would MD cord-329844-w969lczb 437 19 be be VB cord-329844-w969lczb 437 20 an an DT cord-329844-w969lczb 437 21 average average NN cord-329844-w969lczb 437 22 per per IN cord-329844-w969lczb 437 23 residue residue NN cord-329844-w969lczb 437 24 basis basis NN cord-329844-w969lczb 437 25 . . . cord-329844-w969lczb 438 1 One one CD cord-329844-w969lczb 438 2 of of IN cord-329844-w969lczb 438 3 the the DT cord-329844-w969lczb 438 4 more more RBR cord-329844-w969lczb 438 5 recent recent JJ cord-329844-w969lczb 438 6 studies study NNS cord-329844-w969lczb 438 7 included include VBD cord-329844-w969lczb 438 8 the the DT cord-329844-w969lczb 438 9 SARS SARS NNP cord-329844-w969lczb 438 10 - - HYPH cord-329844-w969lczb 438 11 CoV-2 CoV-2 NNP cord-329844-w969lczb 438 12 polyprotein polyprotein NN cord-329844-w969lczb 438 13 which which WDT cord-329844-w969lczb 438 14 contains contain VBZ cord-329844-w969lczb 438 15 proteins protein NNS cord-329844-w969lczb 438 16 with with IN cord-329844-w969lczb 438 17 known know VBN cord-329844-w969lczb 438 18 RNA RNA NNP cord-329844-w969lczb 438 19 and and CC cord-329844-w969lczb 438 20 ribose ribose NN cord-329844-w969lczb 438 21 binding binding NN cord-329844-w969lczb 438 22 functions function NNS cord-329844-w969lczb 438 23 . . . cord-329844-w969lczb 439 1 Out out IN cord-329844-w969lczb 439 2 of of IN cord-329844-w969lczb 439 3 7095 7095 CD cord-329844-w969lczb 439 4 residues residue NNS cord-329844-w969lczb 439 5 , , , cord-329844-w969lczb 439 6 184 184 CD cord-329844-w969lczb 439 7 residues residue NNS cord-329844-w969lczb 439 8 exceeded exceed VBD cord-329844-w969lczb 439 9 scores score NNS cord-329844-w969lczb 439 10 of of IN cord-329844-w969lczb 439 11 100 100 CD cord-329844-w969lczb 439 12 . . . cord-329844-w969lczb 440 1 The the DT cord-329844-w969lczb 440 2 proteins protein NNS cord-329844-w969lczb 440 3 and and CC cord-329844-w969lczb 440 4 domains domain NNS cord-329844-w969lczb 440 5 there there RB cord-329844-w969lczb 440 6 , , , cord-329844-w969lczb 440 7 however however RB cord-329844-w969lczb 440 8 , , , cord-329844-w969lczb 440 9 include include VBP cord-329844-w969lczb 440 10 several several JJ cord-329844-w969lczb 440 11 of of IN cord-329844-w969lczb 440 12 which which WDT cord-329844-w969lczb 440 13 all all DT cord-329844-w969lczb 440 14 possible possible JJ cord-329844-w969lczb 440 15 functions function NNS cord-329844-w969lczb 440 16 are be VBP cord-329844-w969lczb 440 17 not not RB cord-329844-w969lczb 440 18 yet yet RB cord-329844-w969lczb 440 19 known know VBN cord-329844-w969lczb 440 20 . . . cord-329844-w969lczb 441 1 Evidently evidently RB cord-329844-w969lczb 441 2 , , , cord-329844-w969lczb 441 3 those those DT cord-329844-w969lczb 441 4 regions region NNS cord-329844-w969lczb 441 5 with with IN cord-329844-w969lczb 441 6 scores score NNS cord-329844-w969lczb 441 7 over over IN cord-329844-w969lczb 441 8 100 100 CD cord-329844-w969lczb 441 9 , , , cord-329844-w969lczb 441 10 by by IN cord-329844-w969lczb 441 11 virtue virtue NN cord-329844-w969lczb 441 12 of of IN cord-329844-w969lczb 441 13 being be VBG cord-329844-w969lczb 441 14 in in IN cord-329844-w969lczb 441 15 proteins protein NNS cord-329844-w969lczb 441 16 of of IN cord-329844-w969lczb 441 17 SARS SARS NNP cord-329844-w969lczb 441 18 - - HYPH cord-329844-w969lczb 441 19 CoV-2 CoV-2 NNP cord-329844-w969lczb 441 20 , , , cord-329844-w969lczb 441 21 are be VBP cord-329844-w969lczb 441 22 certainly certainly RB cord-329844-w969lczb 441 23 worthy worthy JJ cord-329844-w969lczb 441 24 of of IN cord-329844-w969lczb 441 25 future future JJ cord-329844-w969lczb 441 26 further further JJ cord-329844-w969lczb 441 27 examination examination NN cord-329844-w969lczb 441 28 in in IN cord-329844-w969lczb 441 29 this this DT cord-329844-w969lczb 441 30 project project NN cord-329844-w969lczb 441 31 . . . cord-329844-w969lczb 442 1 However however RB cord-329844-w969lczb 442 2 , , , cord-329844-w969lczb 442 3 this this DT cord-329844-w969lczb 442 4 was be VBD cord-329844-w969lczb 442 5 considered consider VBN cord-329844-w969lczb 442 6 beyond beyond IN cord-329844-w969lczb 442 7 present present JJ cord-329844-w969lczb 442 8 scope scope NN cord-329844-w969lczb 442 9 for for IN cord-329844-w969lczb 442 10 the the DT cord-329844-w969lczb 442 11 present present JJ cord-329844-w969lczb 442 12 paper paper NN cord-329844-w969lczb 442 13 , , , cord-329844-w969lczb 442 14 as as IN cord-329844-w969lczb 442 15 the the DT cord-329844-w969lczb 442 16 focus focus NN cord-329844-w969lczb 442 17 is be VBZ cord-329844-w969lczb 442 18 on on IN cord-329844-w969lczb 442 19 the the DT cord-329844-w969lczb 442 20 spike spike NN cord-329844-w969lczb 442 21 glycoprotein glycoprotein NN cord-329844-w969lczb 442 22 . . . cord-329844-w969lczb 443 1 The the DT cord-329844-w969lczb 443 2 more more RBR cord-329844-w969lczb 443 3 recent recent JJ cord-329844-w969lczb 443 4 studies study NNS cord-329844-w969lczb 443 5 of of IN cord-329844-w969lczb 443 6 sugar sugar NN cord-329844-w969lczb 443 7 binding bind VBG cord-329844-w969lczb 443 8 proteins protein NNS cord-329844-w969lczb 443 9 that that WDT cord-329844-w969lczb 443 10 did do VBD cord-329844-w969lczb 443 11 not not RB cord-329844-w969lczb 443 12 include include VB cord-329844-w969lczb 443 13 suspected suspect VBN cord-329844-w969lczb 443 14 sialic sialic JJ cord-329844-w969lczb 443 15 acid acid NN cord-329844-w969lczb 443 16 or or CC cord-329844-w969lczb 443 17 sialic sialic JJ cord-329844-w969lczb 443 18 acid acid NN cord-329844-w969lczb 443 19 glycan glycan NN cord-329844-w969lczb 443 20 binding bind VBG cord-329844-w969lczb 443 21 regions region NNS cord-329844-w969lczb 443 22 included include VBD cord-329844-w969lczb 443 23 sugar sugar NN cord-329844-w969lczb 443 24 isomerases isomerase NNS cord-329844-w969lczb 443 25 , , , cord-329844-w969lczb 443 26 such such JJ cord-329844-w969lczb 443 27 as as IN cord-329844-w969lczb 443 28 the the DT cord-329844-w969lczb 443 29 L l NN cord-329844-w969lczb 443 30 - - HYPH cord-329844-w969lczb 443 31 rhamnose rhamnose JJ cord-329844-w969lczb 443 32 isomerase isomerase NN cord-329844-w969lczb 443 33 of of IN cord-329844-w969lczb 443 34 Rubinisphaera Rubinisphaera NNP cord-329844-w969lczb 443 35 brasiliensis brasiliensis NN cord-329844-w969lczb 443 36 , , , cord-329844-w969lczb 443 37 which which WDT cord-329844-w969lczb 443 38 with with IN cord-329844-w969lczb 443 39 423 423 CD cord-329844-w969lczb 443 40 residues residue NNS cord-329844-w969lczb 443 41 containing contain VBG cord-329844-w969lczb 443 42 9 9 CD cord-329844-w969lczb 443 43 tryptophans tryptophan NNS cord-329844-w969lczb 443 44 ( ( -LRB- cord-329844-w969lczb 443 45 W W NNP cord-329844-w969lczb 443 46 ) ) -RRB- cord-329844-w969lczb 443 47 was be VBD cord-329844-w969lczb 443 48 a a DT cord-329844-w969lczb 443 49 true true JJ cord-329844-w969lczb 443 50 negative negative JJ cord-329844-w969lczb 443 51 . . . cord-329844-w969lczb 444 1 They -PRON- PRP cord-329844-w969lczb 444 2 also also RB cord-329844-w969lczb 444 3 included include VBD cord-329844-w969lczb 444 4 a a DT cord-329844-w969lczb 444 5 comparison comparison NN cord-329844-w969lczb 444 6 between between IN cord-329844-w969lczb 444 7 sugar sugar NN cord-329844-w969lczb 444 8 transporter transporter NN cord-329844-w969lczb 444 9 proteins protein NNS cord-329844-w969lczb 444 10 , , , cord-329844-w969lczb 444 11 such such JJ cord-329844-w969lczb 444 12 as as IN cord-329844-w969lczb 444 13 the the DT cord-329844-w969lczb 444 14 UDP udp NN cord-329844-w969lczb 444 15 - - HYPH cord-329844-w969lczb 444 16 galactose galactose NN cord-329844-w969lczb 444 17 transporter transporter NN cord-329844-w969lczb 444 18 of of IN cord-329844-w969lczb 444 19 Drosophila Drosophila NNP cord-329844-w969lczb 444 20 melanogaster melanogaster NN cord-329844-w969lczb 444 21 had have VBD cord-329844-w969lczb 444 22 357 357 CD cord-329844-w969lczb 444 23 residues residue NNS cord-329844-w969lczb 444 24 including include VBG cord-329844-w969lczb 444 25 4 4 CD cord-329844-w969lczb 444 26 tryptophans tryptophan NNS cord-329844-w969lczb 444 27 ( ( -LRB- cord-329844-w969lczb 444 28 W W NNP cord-329844-w969lczb 444 29 ) ) -RRB- cord-329844-w969lczb 444 30 , , , cord-329844-w969lczb 444 31 the the DT cord-329844-w969lczb 444 32 PTS PTS NNP cord-329844-w969lczb 444 33 fructose fructose NN cord-329844-w969lczb 444 34 transporter transporter NN cord-329844-w969lczb 444 35 subunit subunit NN cord-329844-w969lczb 444 36 EIIC EIIC NNP cord-329844-w969lczb 444 37 of of IN cord-329844-w969lczb 444 38 Aeromonas Aeromonas NNP cord-329844-w969lczb 444 39 hydrophila hydrophila NN cord-329844-w969lczb 444 40 with with IN cord-329844-w969lczb 444 41 589 589 CD cord-329844-w969lczb 444 42 residues residue NNS cord-329844-w969lczb 444 43 containing contain VBG cord-329844-w969lczb 444 44 7 7 CD cord-329844-w969lczb 444 45 tryptophans tryptophan NNS cord-329844-w969lczb 444 46 , , , cord-329844-w969lczb 444 47 and and CC cord-329844-w969lczb 444 48 a a DT cord-329844-w969lczb 444 49 facilitated facilitate VBN cord-329844-w969lczb 444 50 glucose glucose NN cord-329844-w969lczb 444 51 transporter transporter NN cord-329844-w969lczb 444 52 member member NN cord-329844-w969lczb 444 53 1 1 CD cord-329844-w969lczb 444 54 , , , cord-329844-w969lczb 444 55 which which WDT cord-329844-w969lczb 444 56 despite despite IN cord-329844-w969lczb 444 57 having have VBG cord-329844-w969lczb 444 58 492 492 CD cord-329844-w969lczb 444 59 residues residue NNS cord-329844-w969lczb 444 60 containing contain VBG cord-329844-w969lczb 444 61 6 6 CD cord-329844-w969lczb 444 62 tryptophans tryptophan NNS cord-329844-w969lczb 444 63 ( ( -LRB- cord-329844-w969lczb 444 64 W W NNP cord-329844-w969lczb 444 65 ) ) -RRB- cord-329844-w969lczb 444 66 , , , cord-329844-w969lczb 444 67 all all DT cord-329844-w969lczb 444 68 of of IN cord-329844-w969lczb 444 69 which which WDT cord-329844-w969lczb 444 70 were be VBD cord-329844-w969lczb 444 71 true true JJ cord-329844-w969lczb 444 72 positives positive NNS cord-329844-w969lczb 444 73 by by IN cord-329844-w969lczb 444 74 not not RB cord-329844-w969lczb 444 75 predicting predict VBG cord-329844-w969lczb 444 76 any any DT cord-329844-w969lczb 444 77 sialic sialic JJ cord-329844-w969lczb 444 78 acid acid NN cord-329844-w969lczb 444 79 or or CC cord-329844-w969lczb 444 80 sialic sialic JJ cord-329844-w969lczb 444 81 acid acid NN cord-329844-w969lczb 444 82 glycan glycan NN cord-329844-w969lczb 444 83 ability ability NN cord-329844-w969lczb 444 84 . . . cord-329844-w969lczb 445 1 However however RB cord-329844-w969lczb 445 2 , , , cord-329844-w969lczb 445 3 some some DT cord-329844-w969lczb 445 4 sugar sugar NN cord-329844-w969lczb 445 5 transporters transporter NNS cord-329844-w969lczb 445 6 were be VBD cord-329844-w969lczb 445 7 false false JJ cord-329844-w969lczb 445 8 positives positive NNS cord-329844-w969lczb 445 9 . . . cord-329844-w969lczb 446 1 For for IN cord-329844-w969lczb 446 2 example example NN cord-329844-w969lczb 446 3 , , , cord-329844-w969lczb 446 4 the the DT cord-329844-w969lczb 446 5 arabinose arabinose JJ cord-329844-w969lczb 446 6 transporter transporter NN cord-329844-w969lczb 446 7 of of IN cord-329844-w969lczb 446 8 E. E. NNP cord-329844-w969lczb 446 9 coli coli NNS cord-329844-w969lczb 446 10 had have VBD cord-329844-w969lczb 446 11 the the DT cord-329844-w969lczb 446 12 subsequence subsequence NN cord-329844-w969lczb 446 13 FWLYTA FWLYTA NNP cord-329844-w969lczb 446 14 which which WDT cord-329844-w969lczb 446 15 exceeded exceed VBD cord-329844-w969lczb 446 16 100 100 CD cord-329844-w969lczb 446 17 with with IN cord-329844-w969lczb 446 18 the the DT cord-329844-w969lczb 446 19 tryptophan tryptophan NN cord-329844-w969lczb 446 20 scoring score VBG cord-329844-w969lczb 446 21 104 104 CD cord-329844-w969lczb 446 22 . . . cord-329844-w969lczb 447 1 Armed arm VBN cord-329844-w969lczb 447 2 with with IN cord-329844-w969lczb 447 3 the the DT cord-329844-w969lczb 447 4 above above JJ cord-329844-w969lczb 447 5 predictions prediction NNS cord-329844-w969lczb 447 6 and and CC cord-329844-w969lczb 447 7 insights insight NNS cord-329844-w969lczb 447 8 , , , cord-329844-w969lczb 447 9 one one PRP cord-329844-w969lczb 447 10 may may MD cord-329844-w969lczb 447 11 make make VB cord-329844-w969lczb 447 12 better well RBR cord-329844-w969lczb 447 13 informed informed JJ cord-329844-w969lczb 447 14 judgements judgement NNS cord-329844-w969lczb 447 15 as as IN cord-329844-w969lczb 447 16 to to IN cord-329844-w969lczb 447 17 whether whether IN cord-329844-w969lczb 447 18 a a DT cord-329844-w969lczb 447 19 domain domain NN cord-329844-w969lczb 447 20 for for IN cord-329844-w969lczb 447 21 non non AFX cord-329844-w969lczb 447 22 - - JJ cord-329844-w969lczb 447 23 covalently covalently RB cord-329844-w969lczb 447 24 binding bind VBG cord-329844-w969lczb 447 25 host host NN cord-329844-w969lczb 447 26 sialic sialic NN cord-329844-w969lczb 447 27 acid acid NN cord-329844-w969lczb 447 28 glcycans glcycan NNS cord-329844-w969lczb 447 29 may may MD cord-329844-w969lczb 447 30 exist exist VB cord-329844-w969lczb 447 31 in in IN cord-329844-w969lczb 447 32 the the DT cord-329844-w969lczb 447 33 SARS SARS NNP cord-329844-w969lczb 447 34 - - HYPH cord-329844-w969lczb 447 35 CoV-2 CoV-2 NNP cord-329844-w969lczb 447 36 spike spike NN cord-329844-w969lczb 447 37 protein protein NN cord-329844-w969lczb 447 38 . . . cord-329844-w969lczb 448 1 The the DT cord-329844-w969lczb 448 2 above above JJ cord-329844-w969lczb 448 3 results result NNS cord-329844-w969lczb 448 4 suggesting suggest VBG cord-329844-w969lczb 448 5 the the DT cord-329844-w969lczb 448 6 ability ability NN cord-329844-w969lczb 448 7 to to TO cord-329844-w969lczb 448 8 distinguish distinguish VB cord-329844-w969lczb 448 9 between between IN cord-329844-w969lczb 448 10 three three CD cord-329844-w969lczb 448 11 classes class NNS cord-329844-w969lczb 448 12 of of IN cord-329844-w969lczb 448 13 protein protein NN cord-329844-w969lczb 448 14 in in IN cord-329844-w969lczb 448 15 relation relation NN cord-329844-w969lczb 448 16 to to IN cord-329844-w969lczb 448 17 sialic sialic JJ cord-329844-w969lczb 448 18 acid acid NN cord-329844-w969lczb 448 19 glycan glycan NN cord-329844-w969lczb 448 20 binding binding NN cord-329844-w969lczb 448 21 is be VBZ cord-329844-w969lczb 448 22 perhaps perhaps RB cord-329844-w969lczb 448 23 surprising surprising JJ cord-329844-w969lczb 448 24 , , , cord-329844-w969lczb 448 25 not not RB cord-329844-w969lczb 448 26 least least JJS cord-329844-w969lczb 448 27 because because IN cord-329844-w969lczb 448 28 non non JJ cord-329844-w969lczb 448 29 - - JJ cord-329844-w969lczb 448 30 sialic sialic JJ cord-329844-w969lczb 448 31 sugars sugar NNS cord-329844-w969lczb 448 32 such such JJ cord-329844-w969lczb 448 33 as as IN cord-329844-w969lczb 448 34 fucose fucose JJ cord-329844-w969lczb 448 35 and and CC cord-329844-w969lczb 448 36 mannose mannose NN cord-329844-w969lczb 448 37 can can MD cord-329844-w969lczb 448 38 occur occur VB cord-329844-w969lczb 448 39 in in IN cord-329844-w969lczb 448 40 cell cell NN cord-329844-w969lczb 448 41 surface surface NN cord-329844-w969lczb 448 42 glycans glycan NNS cord-329844-w969lczb 448 43 ( ( -LRB- cord-329844-w969lczb 448 44 including include VBG cord-329844-w969lczb 448 45 sialic sialic JJ cord-329844-w969lczb 448 46 acid acid NN cord-329844-w969lczb 448 47 glycans glycan NNS cord-329844-w969lczb 448 48 ) ) -RRB- cord-329844-w969lczb 448 49 as as IN cord-329844-w969lczb 448 50 indicated indicate VBN cord-329844-w969lczb 448 51 in in IN cord-329844-w969lczb 448 52 Introduction Introduction NNP cord-329844-w969lczb 448 53 Section Section NNP cord-329844-w969lczb 448 54 1.3 1.3 CD cord-329844-w969lczb 448 55 . . . cord-329844-w969lczb 449 1 This this DT cord-329844-w969lczb 449 2 is be VBZ cord-329844-w969lczb 449 3 discussed discuss VBN cord-329844-w969lczb 449 4 in in IN cord-329844-w969lczb 449 5 Discussion Discussion NNP cord-329844-w969lczb 449 6 Section Section NNP cord-329844-w969lczb 449 7 5.2 5.2 CD cord-329844-w969lczb 449 8 . . . cord-329844-w969lczb 450 1 At at IN cord-329844-w969lczb 450 2 this this DT cord-329844-w969lczb 450 3 stage stage NN cord-329844-w969lczb 450 4 , , , cord-329844-w969lczb 450 5 only only RB cord-329844-w969lczb 450 6 the the DT cord-329844-w969lczb 450 7 ability ability NN cord-329844-w969lczb 450 8 to to TO cord-329844-w969lczb 450 9 show show VB cord-329844-w969lczb 450 10 propensities propensity NNS cord-329844-w969lczb 450 11 in in IN cord-329844-w969lczb 450 12 different different JJ cord-329844-w969lczb 450 13 regions region NNS cord-329844-w969lczb 450 14 of of IN cord-329844-w969lczb 450 15 the the DT cord-329844-w969lczb 450 16 SARS SARS NNP cord-329844-w969lczb 450 17 - - HYPH cord-329844-w969lczb 450 18 CoV-2 CoV-2 NNP cord-329844-w969lczb 450 19 ( ( -LRB- cord-329844-w969lczb 450 20 GenBank GenBank NNP cord-329844-w969lczb 450 21 entry entry NN cord-329844-w969lczb 450 22 MN908947.3 MN908947.3 NNP cord-329844-w969lczb 450 23 ) ) -RRB- cord-329844-w969lczb 450 24 spike spike NN cord-329844-w969lczb 450 25 glycoprotein glycoprotein NN cord-329844-w969lczb 450 26 is be VBZ cord-329844-w969lczb 450 27 required require VBN cord-329844-w969lczb 450 28 . . . cord-329844-w969lczb 450 29 _SP cord-329844-w969lczb 451 1 In in IN cord-329844-w969lczb 451 2 this this DT cord-329844-w969lczb 451 3 stage stage NN cord-329844-w969lczb 451 4 of of IN cord-329844-w969lczb 451 5 the the DT cord-329844-w969lczb 451 6 study study NN cord-329844-w969lczb 451 7 the the DT cord-329844-w969lczb 451 8 predicted predict VBN cord-329844-w969lczb 451 9 regions region NNS cord-329844-w969lczb 451 10 of of IN cord-329844-w969lczb 451 11 the the DT cord-329844-w969lczb 451 12 SARS SARS NNP cord-329844-w969lczb 451 13 - - HYPH cord-329844-w969lczb 451 14 CoV CoV NNP cord-329844-w969lczb 451 15 spike spike NN cord-329844-w969lczb 451 16 protein protein NN cord-329844-w969lczb 451 17 were be VBD cord-329844-w969lczb 451 18 examined examine VBN cord-329844-w969lczb 451 19 in in IN cord-329844-w969lczb 451 20 more more JJR cord-329844-w969lczb 451 21 detail detail NN cord-329844-w969lczb 451 22 . . . cord-329844-w969lczb 452 1 While while IN cord-329844-w969lczb 452 2 as as IN cord-329844-w969lczb 452 3 discussed discuss VBN cord-329844-w969lczb 452 4 above above IN cord-329844-w969lczb 452 5 tryptophan tryptophan NN cord-329844-w969lczb 452 6 can can MD cord-329844-w969lczb 452 7 be be VB cord-329844-w969lczb 452 8 involved involve VBN cord-329844-w969lczb 452 9 in in IN cord-329844-w969lczb 452 10 the the DT cord-329844-w969lczb 452 11 fundamental fundamental JJ cord-329844-w969lczb 452 12 structure structure NN cord-329844-w969lczb 452 13 of of IN cord-329844-w969lczb 452 14 a a DT cord-329844-w969lczb 452 15 sialic sialic JJ cord-329844-w969lczb 452 16 acid acid NN cord-329844-w969lczb 452 17 binding bind VBG cord-329844-w969lczb 452 18 domain domain NN cord-329844-w969lczb 452 19 , , , cord-329844-w969lczb 452 20 an an DT cord-329844-w969lczb 452 21 exposed expose VBN cord-329844-w969lczb 452 22 tryptophan tryptophan NN cord-329844-w969lczb 452 23 like like IN cord-329844-w969lczb 452 24 that that DT cord-329844-w969lczb 452 25 binding bind VBG cord-329844-w969lczb 452 26 a a DT cord-329844-w969lczb 452 27 sialic sialic JJ cord-329844-w969lczb 452 28 acid acid NN cord-329844-w969lczb 452 29 glycan glycan NN cord-329844-w969lczb 452 30 in in IN cord-329844-w969lczb 452 31 Fig Fig NNP cord-329844-w969lczb 452 32 . . . cord-329844-w969lczb 453 1 2 2 CD cord-329844-w969lczb 453 2 would would MD cord-329844-w969lczb 453 3 be be VB cord-329844-w969lczb 453 4 particularly particularly RB cord-329844-w969lczb 453 5 persuasive persuasive JJ cord-329844-w969lczb 453 6 . . . cord-329844-w969lczb 454 1 The the DT cord-329844-w969lczb 454 2 first first JJ cord-329844-w969lczb 454 3 predicted predict VBN cord-329844-w969lczb 454 4 sialic sialic JJ cord-329844-w969lczb 454 5 acid acid NN cord-329844-w969lczb 454 6 binding bind VBG cord-329844-w969lczb 454 7 motif motif NN cord-329844-w969lczb 454 8 is be VBZ cord-329844-w969lczb 454 9 segment segment NN cord-329844-w969lczb 454 10 FFSNVTWFHAIHV FFSNVTWFHAIHV NNP cord-329844-w969lczb 454 11 58 58 CD cord-329844-w969lczb 454 12 - - SYM cord-329844-w969lczb 454 13 70 70 CD cord-329844-w969lczb 454 14 with with IN cord-329844-w969lczb 454 15 SABR SABR NNP cord-329844-w969lczb 454 16 - - HYPH cord-329844-w969lczb 454 17 P p NN cord-329844-w969lczb 454 18 score score NN cord-329844-w969lczb 454 19 ranging range VBG cord-329844-w969lczb 454 20 from from IN cord-329844-w969lczb 454 21 101 101 CD cord-329844-w969lczb 454 22 for for IN cord-329844-w969lczb 454 23 valine valine NN cord-329844-w969lczb 454 24 ( ( -LRB- cord-329844-w969lczb 454 25 V v NN cord-329844-w969lczb 454 26 ) ) -RRB- cord-329844-w969lczb 454 27 to to IN cord-329844-w969lczb 454 28 113 113 CD cord-329844-w969lczb 454 29 for for IN cord-329844-w969lczb 454 30 tryptophan tryptophan NN cord-329844-w969lczb 454 31 ( ( -LRB- cord-329844-w969lczb 454 32 W W NNP cord-329844-w969lczb 454 33 ) ) -RRB- cord-329844-w969lczb 454 34 and and CC cord-329844-w969lczb 454 35 for for IN cord-329844-w969lczb 454 36 phenylalanine phenylalanine NN cord-329844-w969lczb 454 37 ( ( -LRB- cord-329844-w969lczb 454 38 As as IN cord-329844-w969lczb 454 39 shown show VBN cord-329844-w969lczb 454 40 in in IN cord-329844-w969lczb 454 41 fig fig NN cord-329844-w969lczb 454 42 . . . cord-329844-w969lczb 455 1 6 6 CD cord-329844-w969lczb 455 2 , , , cord-329844-w969lczb 455 3 the the DT cord-329844-w969lczb 455 4 tryptophan tryptophan NN cord-329844-w969lczb 455 5 sidechain sidechain NN cord-329844-w969lczb 455 6 in in IN cord-329844-w969lczb 455 7 FFSNVTWFHAIHV FFSNVTWFHAIHV NNP cord-329844-w969lczb 455 8 as as IN cord-329844-w969lczb 455 9 residues residue NNS cord-329844-w969lczb 455 10 58 58 CD cord-329844-w969lczb 455 11 - - SYM cord-329844-w969lczb 455 12 70 70 CD cord-329844-w969lczb 455 13 of of IN cord-329844-w969lczb 455 14 the the DT cord-329844-w969lczb 455 15 sars sars NNP cord-329844-w969lczb 455 16 - - HYPH cord-329844-w969lczb 455 17 cov-3 cov-3 NNP cord-329844-w969lczb 455 18 spike spike NN cord-329844-w969lczb 455 19 glycoprotein glycoprotein NN cord-329844-w969lczb 455 20 is be VBZ cord-329844-w969lczb 455 21 exposed expose VBN cord-329844-w969lczb 455 22 in in IN cord-329844-w969lczb 455 23 a a DT cord-329844-w969lczb 455 24 site site NN cord-329844-w969lczb 455 25 that that WDT cord-329844-w969lczb 455 26 has have VBZ cord-329844-w969lczb 455 27 all all PDT cord-329844-w969lczb 455 28 the the DT cord-329844-w969lczb 455 29 appearance appearance NN cord-329844-w969lczb 455 30 of of IN cord-329844-w969lczb 455 31 a a DT cord-329844-w969lczb 455 32 sialic sialic JJ cord-329844-w969lczb 455 33 acid acid NN cord-329844-w969lczb 455 34 glycan glycan NN cord-329844-w969lczb 455 35 binding binding NN cord-329844-w969lczb 455 36 site site NN cord-329844-w969lczb 455 37 , , , cord-329844-w969lczb 455 38 comparable comparable JJ cord-329844-w969lczb 455 39 with with IN cord-329844-w969lczb 455 40 the the DT cord-329844-w969lczb 455 41 influenza influenza NN cord-329844-w969lczb 455 42 virus virus NN cord-329844-w969lczb 455 43 B b NN cord-329844-w969lczb 455 44 neuraminidase neuraminidase NN cord-329844-w969lczb 455 45 ( ( -LRB- cord-329844-w969lczb 455 46 PDB PDB NNP cord-329844-w969lczb 455 47 entry entry NN cord-329844-w969lczb 455 48 2BAT 2bat CD cord-329844-w969lczb 455 49 ) ) -RRB- cord-329844-w969lczb 455 50 tryptophan tryptophan NN cord-329844-w969lczb 455 51 site site NN cord-329844-w969lczb 455 52 known know VBN cord-329844-w969lczb 455 53 to to TO cord-329844-w969lczb 455 54 have have VB cord-329844-w969lczb 455 55 interaction interaction NN cord-329844-w969lczb 455 56 with with IN cord-329844-w969lczb 455 57 and and CC cord-329844-w969lczb 455 58 sialic sialic JJ cord-329844-w969lczb 455 59 acid acid NN cord-329844-w969lczb 455 60 , , , cord-329844-w969lczb 455 61 that that WDT cord-329844-w969lczb 455 62 was be VBD cord-329844-w969lczb 455 63 shown show VBN cord-329844-w969lczb 455 64 in in IN cord-329844-w969lczb 455 65 Fig Fig NNP cord-329844-w969lczb 455 66 . . NNP cord-329844-w969lczb 455 67 2 2 CD cord-329844-w969lczb 455 68 . . . cord-329844-w969lczb 456 1 The the DT cord-329844-w969lczb 456 2 Tryptophan tryptophan NN cord-329844-w969lczb 456 3 sidechain sidechain NN cord-329844-w969lczb 456 4 in in IN cord-329844-w969lczb 456 5 FFSNVTWFHAIHV FFSNVTWFHAIHV NNP cord-329844-w969lczb 456 6 58 58 CD cord-329844-w969lczb 456 7 - - SYM cord-329844-w969lczb 456 8 70 70 CD cord-329844-w969lczb 456 9 of of IN cord-329844-w969lczb 456 10 Spike Spike NNP cord-329844-w969lczb 456 11 Glycoprotein Glycoprotein NNP cord-329844-w969lczb 456 12 is be VBZ cord-329844-w969lczb 456 13 Exposed expose VBN cord-329844-w969lczb 456 14 in in IN cord-329844-w969lczb 456 15 a a DT cord-329844-w969lczb 456 16 Site site NN cord-329844-w969lczb 456 17 that that WDT cord-329844-w969lczb 456 18 Has have VBZ cord-329844-w969lczb 456 19 all all PDT cord-329844-w969lczb 456 20 the the DT cord-329844-w969lczb 456 21 Appearance Appearance NNP cord-329844-w969lczb 456 22 of of IN cord-329844-w969lczb 456 23 a a DT cord-329844-w969lczb 456 24 Sialic Sialic NNP cord-329844-w969lczb 456 25 Acid acid NN cord-329844-w969lczb 456 26 Glycan Glycan NNP cord-329844-w969lczb 456 27 binding binding NN cord-329844-w969lczb 456 28 site site NN cord-329844-w969lczb 456 29 . . . cord-329844-w969lczb 457 1 It -PRON- PRP cord-329844-w969lczb 457 2 is be VBZ cord-329844-w969lczb 457 3 useful useful JJ cord-329844-w969lczb 457 4 to to TO cord-329844-w969lczb 457 5 see see VB cord-329844-w969lczb 457 6 how how WRB cord-329844-w969lczb 457 7 recurrent recurrent JJ cord-329844-w969lczb 457 8 a a DT cord-329844-w969lczb 457 9 potential potential JJ cord-329844-w969lczb 457 10 more more RBR cord-329844-w969lczb 457 11 universal universal JJ cord-329844-w969lczb 457 12 motif motif NN cord-329844-w969lczb 457 13 may may MD cord-329844-w969lczb 457 14 be be VB cord-329844-w969lczb 457 15 , , , cord-329844-w969lczb 457 16 to to TO cord-329844-w969lczb 457 17 give give VB cord-329844-w969lczb 457 18 insight insight NN cord-329844-w969lczb 457 19 , , , cord-329844-w969lczb 457 20 to to TO cord-329844-w969lczb 457 21 avoid avoid VB cord-329844-w969lczb 457 22 cross cross JJ cord-329844-w969lczb 457 23 reactions reaction NNS cord-329844-w969lczb 457 24 of of IN cord-329844-w969lczb 457 25 vaccine vaccine NN cord-329844-w969lczb 457 26 in in IN cord-329844-w969lczb 457 27 human human JJ cord-329844-w969lczb 457 28 and and CC cord-329844-w969lczb 457 29 veterinary veterinary JJ cord-329844-w969lczb 457 30 patients patient NNS cord-329844-w969lczb 457 31 as as IN cord-329844-w969lczb 457 32 hosts host NNS cord-329844-w969lczb 457 33 , , , cord-329844-w969lczb 457 34 to to TO cord-329844-w969lczb 457 35 detect detect VB cord-329844-w969lczb 457 36 an an DT cord-329844-w969lczb 457 37 underlying underlying JJ cord-329844-w969lczb 457 38 common common JJ cord-329844-w969lczb 457 39 function function NN cord-329844-w969lczb 457 40 that that WDT cord-329844-w969lczb 457 41 one one PRP cord-329844-w969lczb 457 42 might may MD cord-329844-w969lczb 457 43 not not RB cord-329844-w969lczb 457 44 wish wish VB cord-329844-w969lczb 457 45 to to TO cord-329844-w969lczb 457 46 inhibit inhibit VB cord-329844-w969lczb 457 47 in in IN cord-329844-w969lczb 457 48 the the DT cord-329844-w969lczb 457 49 host host NN cord-329844-w969lczb 457 50 with with IN cord-329844-w969lczb 457 51 an an DT cord-329844-w969lczb 457 52 anti anti JJ cord-329844-w969lczb 457 53 - - JJ cord-329844-w969lczb 457 54 viral viral JJ cord-329844-w969lczb 457 55 therapeutic therapeutic JJ cord-329844-w969lczb 457 56 , , , cord-329844-w969lczb 457 57 and and CC cord-329844-w969lczb 457 58 so so RB cord-329844-w969lczb 457 59 on on RB cord-329844-w969lczb 457 60 . . . cord-329844-w969lczb 458 1 A a DT cord-329844-w969lczb 458 2 BLAST blast NN cord-329844-w969lczb 458 3 search search NN cord-329844-w969lczb 458 4 on on IN cord-329844-w969lczb 458 5 non non NNS cord-329844-w969lczb 458 6 - - NNS cord-329844-w969lczb 458 7 viruses virus NNS cord-329844-w969lczb 458 8 picks pick NNS cord-329844-w969lczb 458 9 this this DT cord-329844-w969lczb 458 10 subsequence subsequence NN cord-329844-w969lczb 458 11 up up RP cord-329844-w969lczb 458 12 as as IN cord-329844-w969lczb 458 13 FFSNVTNIAWIHAI FFSNVTNIAWIHAI NNP cord-329844-w969lczb 458 14 of of IN cord-329844-w969lczb 458 15 Parasteatoda Parasteatoda NNP cord-329844-w969lczb 458 16 tepidariorum tepidariorum NNP cord-329844-w969lczb 458 17 , , , cord-329844-w969lczb 458 18 the the DT cord-329844-w969lczb 458 19 common common JJ cord-329844-w969lczb 458 20 house house NNP cord-329844-w969lczb 458 21 spider spider NN cord-329844-w969lczb 458 22 , , , cord-329844-w969lczb 458 23 and and CC cord-329844-w969lczb 458 24 related related JJ cord-329844-w969lczb 458 25 sequences sequence NNS cord-329844-w969lczb 458 26 , , , cord-329844-w969lczb 458 27 a a DT cord-329844-w969lczb 458 28 zinc zinc NN cord-329844-w969lczb 458 29 figure figure NN cord-329844-w969lczb 458 30 domain domain NN cord-329844-w969lczb 458 31 because because IN cord-329844-w969lczb 458 32 it -PRON- PRP cord-329844-w969lczb 458 33 contains contain VBZ cord-329844-w969lczb 458 34 FYVE FYVE NNP cord-329844-w969lczb 458 35 the the DT cord-329844-w969lczb 458 36 zinc zinc NN cord-329844-w969lczb 458 37 finger finger NN cord-329844-w969lczb 458 38 motif motif NN cord-329844-w969lczb 458 39 , , , cord-329844-w969lczb 458 40 but but CC cord-329844-w969lczb 458 41 more more RBR cord-329844-w969lczb 458 42 abundantly abundantly RB cord-329844-w969lczb 458 43 it -PRON- PRP cord-329844-w969lczb 458 44 picks pick VBZ cord-329844-w969lczb 458 45 up up RP cord-329844-w969lczb 458 46 sugar sugar NN cord-329844-w969lczb 458 47 - - HYPH cord-329844-w969lczb 458 48 binding bind VBG cord-329844-w969lczb 458 49 proteins protein NNS cord-329844-w969lczb 458 50 such such JJ cord-329844-w969lczb 458 51 as as IN cord-329844-w969lczb 458 52 glycosyl glycosyl JJ cord-329844-w969lczb 458 53 transferases transferase NNS cord-329844-w969lczb 458 54 such such JJ cord-329844-w969lczb 458 55 as as IN cord-329844-w969lczb 458 56 FFSPVWARTPNVTWFH FFSPVWARTPNVTWFH NNP cord-329844-w969lczb 458 57 - - HYPH cord-329844-w969lczb 458 58 HV HV NNP cord-329844-w969lczb 458 59 of of IN cord-329844-w969lczb 458 60 actinobacteria actinobacteria NN cord-329844-w969lczb 458 61 , , , cord-329844-w969lczb 458 62 Ribulosephosphate Ribulosephosphate NNP cord-329844-w969lczb 458 63 3-epimerase 3-epimerase CD cord-329844-w969lczb 458 64 of of IN cord-329844-w969lczb 458 65 animals animal NNS cord-329844-w969lczb 458 66 , , , cord-329844-w969lczb 458 67 a a DT cord-329844-w969lczb 458 68 - - HYPH cord-329844-w969lczb 458 69 amylase amylase NN cord-329844-w969lczb 458 70 of of IN cord-329844-w969lczb 458 71 the the DT cord-329844-w969lczb 458 72 Chitinophagia Chitinophagia NNP cord-329844-w969lczb 458 73 ( ( -LRB- cord-329844-w969lczb 458 74 " " `` cord-329844-w969lczb 458 75 chitin chitin NN cord-329844-w969lczb 458 76 eating eat VBG cord-329844-w969lczb 458 77 " " '' cord-329844-w969lczb 458 78 ) ) -RRB- cord-329844-w969lczb 458 79 bacteria bacteria NNS cord-329844-w969lczb 458 80 , , , cord-329844-w969lczb 458 81 C c NN cord-329844-w969lczb 458 82 - - HYPH cord-329844-w969lczb 458 83 type type NN cord-329844-w969lczb 458 84 lectin lectin NN cord-329844-w969lczb 458 85 37Db 37db CD cord-329844-w969lczb 458 86 - - HYPH cord-329844-w969lczb 458 87 like like JJ cord-329844-w969lczb 458 88 of of IN cord-329844-w969lczb 458 89 Drosophila drosophila JJ cord-329844-w969lczb 458 90 hydei hydei NN cord-329844-w969lczb 458 91 , , , cord-329844-w969lczb 458 92 and and CC cord-329844-w969lczb 458 93 related related JJ cord-329844-w969lczb 458 94 sugar sugar NN cord-329844-w969lczb 458 95 binding bind VBG cord-329844-w969lczb 458 96 proteins protein NNS cord-329844-w969lczb 458 97 , , , cord-329844-w969lczb 458 98 all all DT cord-329844-w969lczb 458 99 varying vary VBG cord-329844-w969lczb 458 100 around around IN cord-329844-w969lczb 458 101 100 100 CD cord-329844-w969lczb 458 102 % % NN cord-329844-w969lczb 458 103 cover cover NN cord-329844-w969lczb 458 104 and and CC cord-329844-w969lczb 458 105 55 55 CD cord-329844-w969lczb 458 106 % % NN cord-329844-w969lczb 458 107 match match NN cord-329844-w969lczb 458 108 , , , cord-329844-w969lczb 458 109 92 92 CD cord-329844-w969lczb 458 110 % % NN cord-329844-w969lczb 458 111 cover cover NN cord-329844-w969lczb 458 112 71 71 CD cord-329844-w969lczb 458 113 % % NN cord-329844-w969lczb 458 114 match match NN cord-329844-w969lczb 458 115 , , , cord-329844-w969lczb 458 116 76 76 CD cord-329844-w969lczb 458 117 % % NN cord-329844-w969lczb 458 118 cover cover NN cord-329844-w969lczb 458 119 70 70 CD cord-329844-w969lczb 458 120 % % NN cord-329844-w969lczb 458 121 match match NN cord-329844-w969lczb 458 122 , , , cord-329844-w969lczb 458 123 and and CC cord-329844-w969lczb 458 124 so so RB cord-329844-w969lczb 458 125 on on RB cord-329844-w969lczb 458 126 . . . cord-329844-w969lczb 459 1 The the DT cord-329844-w969lczb 459 2 second second JJ cord-329844-w969lczb 459 3 predicted predict VBD cord-329844-w969lczb 459 4 sialic sialic JJ cord-329844-w969lczb 459 5 acid acid NN cord-329844-w969lczb 459 6 binding binding NN cord-329844-w969lczb 459 7 subsequence subsequence NN cord-329844-w969lczb 459 8 SSSGWTAGAAA SSSGWTAGAAA NNP cord-329844-w969lczb 459 9 has have VBZ cord-329844-w969lczb 459 10 been be VBN cord-329844-w969lczb 459 11 of of IN cord-329844-w969lczb 459 12 interest interest NN cord-329844-w969lczb 459 13 in in IN cord-329844-w969lczb 459 14 the the DT cord-329844-w969lczb 459 15 preceding precede VBG cord-329844-w969lczb 459 16 Sections section NNS cord-329844-w969lczb 459 17 4.1 4.1 CD cord-329844-w969lczb 459 18 - - SYM cord-329844-w969lczb 459 19 4.4 4.4 CD cord-329844-w969lczb 459 20 , , , cord-329844-w969lczb 459 21 where where WRB cord-329844-w969lczb 459 22 it -PRON- PRP cord-329844-w969lczb 459 23 seemed seem VBD cord-329844-w969lczb 459 24 a a DT cord-329844-w969lczb 459 25 likely likely JJ cord-329844-w969lczb 459 26 sugar sugar NN cord-329844-w969lczb 459 27 binding binding NN cord-329844-w969lczb 459 28 site site NN cord-329844-w969lczb 459 29 based base VBN cord-329844-w969lczb 459 30 on on IN cord-329844-w969lczb 459 31 circumstantial circumstantial JJ cord-329844-w969lczb 459 32 evidence evidence NN cord-329844-w969lczb 459 33 such such JJ cord-329844-w969lczb 459 34 as as IN cord-329844-w969lczb 459 35 homologies homology NNS cord-329844-w969lczb 459 36 to to IN cord-329844-w969lczb 459 37 neurmaindiases neurmaindiases NNP cord-329844-w969lczb 459 38 and and CC cord-329844-w969lczb 459 39 glycan glycan NN cord-329844-w969lczb 459 40 esterases esterase NNS cord-329844-w969lczb 459 41 . . . cord-329844-w969lczb 460 1 Unfortunately unfortunately RB cord-329844-w969lczb 460 2 , , , cord-329844-w969lczb 460 3 it -PRON- PRP cord-329844-w969lczb 460 4 lies lie VBZ cord-329844-w969lczb 460 5 in in IN cord-329844-w969lczb 460 6 the the DT cord-329844-w969lczb 460 7 range range NN cord-329844-w969lczb 460 8 that that WDT cord-329844-w969lczb 460 9 generally generally RB cord-329844-w969lczb 460 10 disordered disorder VBN cord-329844-w969lczb 460 11 in in IN cord-329844-w969lczb 460 12 experimental experimental JJ cord-329844-w969lczb 460 13 3D 3d JJ cord-329844-w969lczb 460 14 structure structure NN cord-329844-w969lczb 460 15 , , , cord-329844-w969lczb 460 16 e.g. e.g. RB cord-329844-w969lczb 460 17 residues residue NNS cord-329844-w969lczb 460 18 246 246 CD cord-329844-w969lczb 460 19 - - HYPH cord-329844-w969lczb 460 20 262 262 CD cord-329844-w969lczb 460 21 in in IN cord-329844-w969lczb 460 22 VVX vvx NN cord-329844-w969lczb 460 23 ( ( -LRB- cord-329844-w969lczb 460 24 spike spike NN cord-329844-w969lczb 460 25 closed close VBN cord-329844-w969lczb 460 26 state state NN cord-329844-w969lczb 460 27 ) ) -RRB- cord-329844-w969lczb 460 28 and and CC cord-329844-w969lczb 460 29 243 243 CD cord-329844-w969lczb 460 30 - - SYM cord-329844-w969lczb 460 31 262 262 CD cord-329844-w969lczb 460 32 in in IN cord-329844-w969lczb 460 33 VYB VYB NNP cord-329844-w969lczb 460 34 ( ( -LRB- cord-329844-w969lczb 460 35 spike spike XX cord-329844-w969lczb 460 36 open open JJ cord-329844-w969lczb 460 37 state state NN cord-329844-w969lczb 460 38 ) ) -RRB- cord-329844-w969lczb 460 39 . . . cord-329844-w969lczb 461 1 It -PRON- PRP cord-329844-w969lczb 461 2 also also RB cord-329844-w969lczb 461 3 has have VBZ cord-329844-w969lczb 461 4 modest modest JJ cord-329844-w969lczb 461 5 maximum maximum JJ cord-329844-w969lczb 461 6 scores score NNS cord-329844-w969lczb 461 7 of of IN cord-329844-w969lczb 461 8 109 109 CD cord-329844-w969lczb 461 9 , , , cord-329844-w969lczb 461 10 but but CC cord-329844-w969lczb 461 11 the the DT cord-329844-w969lczb 461 12 above above JJ cord-329844-w969lczb 461 13 considerations consideration NNS cord-329844-w969lczb 461 14 do do VBP cord-329844-w969lczb 461 15 not not RB cord-329844-w969lczb 461 16 prohibit prohibit VB cord-329844-w969lczb 461 17 its -PRON- PRP$ cord-329844-w969lczb 461 18 potential potential JJ cord-329844-w969lczb 461 19 importance importance NN cord-329844-w969lczb 461 20 . . . cord-329844-w969lczb 462 1 Again again RB cord-329844-w969lczb 462 2 , , , cord-329844-w969lczb 462 3 as as IN cord-329844-w969lczb 462 4 for for IN cord-329844-w969lczb 462 5 the the DT cord-329844-w969lczb 462 6 previous previous JJ cord-329844-w969lczb 462 7 subsequence subsequence NN cord-329844-w969lczb 462 8 , , , cord-329844-w969lczb 462 9 it -PRON- PRP cord-329844-w969lczb 462 10 is be VBZ cord-329844-w969lczb 462 11 useful useful JJ cord-329844-w969lczb 462 12 to to TO cord-329844-w969lczb 462 13 see see VB cord-329844-w969lczb 462 14 how how WRB cord-329844-w969lczb 462 15 recurrent recurrent JJ cord-329844-w969lczb 462 16 a a DT cord-329844-w969lczb 462 17 potential potential JJ cord-329844-w969lczb 462 18 more more RBR cord-329844-w969lczb 462 19 universal universal JJ cord-329844-w969lczb 462 20 motif motif NN cord-329844-w969lczb 462 21 may may MD cord-329844-w969lczb 462 22 be be VB cord-329844-w969lczb 462 23 . . . cord-329844-w969lczb 463 1 BLASTp BLASTp NNP cord-329844-w969lczb 463 2 searches search NNS cord-329844-w969lczb 463 3 of of IN cord-329844-w969lczb 463 4 non non NNS cord-329844-w969lczb 463 5 - - NNS cord-329844-w969lczb 463 6 viruses virus NNS cord-329844-w969lczb 463 7 find find VBP cord-329844-w969lczb 463 8 subsequences subsequence NNS cord-329844-w969lczb 463 9 in in IN cord-329844-w969lczb 463 10 sugar sugar NN cord-329844-w969lczb 463 11 binding binding NN cord-329844-w969lczb 463 12 proteins protein NNS cord-329844-w969lczb 463 13 such such JJ cord-329844-w969lczb 463 14 as as IN cord-329844-w969lczb 463 15 SSAGWTAGAA SSAGWTAGAA NNP cord-329844-w969lczb 463 16 of of IN cord-329844-w969lczb 463 17 microbacteria microbacteria NNP cord-329844-w969lczb 463 18 ( ( -LRB- cord-329844-w969lczb 463 19 90 90 CD cord-329844-w969lczb 463 20 % % NN cord-329844-w969lczb 463 21 cover cover NN cord-329844-w969lczb 463 22 90 90 CD cord-329844-w969lczb 463 23 % % NN cord-329844-w969lczb 463 24 match match NN cord-329844-w969lczb 463 25 ) ) -RRB- cord-329844-w969lczb 463 26 , , , cord-329844-w969lczb 463 27 but but CC cord-329844-w969lczb 463 28 compared compare VBN cord-329844-w969lczb 463 29 with with IN cord-329844-w969lczb 463 30 FFSNVTWFHAIHV FFSNVTWFHAIHV NNP cord-329844-w969lczb 463 31 discussed discuss VBN cord-329844-w969lczb 463 32 above above RB cord-329844-w969lczb 463 33 , , , cord-329844-w969lczb 463 34 searche searche NN cord-329844-w969lczb 463 35 generate generate VBP cord-329844-w969lczb 463 36 a a DT cord-329844-w969lczb 463 37 lot lot NN cord-329844-w969lczb 463 38 of of IN cord-329844-w969lczb 463 39 closer close JJR cord-329844-w969lczb 463 40 matches match NNS cord-329844-w969lczb 463 41 ( ( -LRB- cord-329844-w969lczb 463 42 many many JJ cord-329844-w969lczb 463 43 100 100 CD cord-329844-w969lczb 463 44 % % NN cord-329844-w969lczb 463 45 matches match NNS cord-329844-w969lczb 463 46 with with IN cord-329844-w969lczb 463 47 the the DT cord-329844-w969lczb 463 48 top top JJ cord-329844-w969lczb 463 49 99 99 CD cord-329844-w969lczb 463 50 at at IN cord-329844-w969lczb 463 51 100 100 CD cord-329844-w969lczb 463 52 % % NN cord-329844-w969lczb 463 53 cover cover NN cord-329844-w969lczb 463 54 82 82 CD cord-329844-w969lczb 463 55 % % NN cord-329844-w969lczb 463 56 match match NN cord-329844-w969lczb 463 57 or or CC cord-329844-w969lczb 463 58 better well JJR cord-329844-w969lczb 463 59 ) ) -RRB- cord-329844-w969lczb 463 60 which which WDT cord-329844-w969lczb 463 61 , , , cord-329844-w969lczb 463 62 however however RB cord-329844-w969lczb 463 63 , , , cord-329844-w969lczb 463 64 involve involve VBP cord-329844-w969lczb 463 65 an an DT cord-329844-w969lczb 463 66 even even RB cord-329844-w969lczb 463 67 more more RBR cord-329844-w969lczb 463 68 diverse diverse JJ cord-329844-w969lczb 463 69 set set NN cord-329844-w969lczb 463 70 of of IN cord-329844-w969lczb 463 71 proteins protein NNS cord-329844-w969lczb 463 72 . . . cord-329844-w969lczb 464 1 At at IN cord-329844-w969lczb 464 2 first first JJ cord-329844-w969lczb 464 3 examination examination NN cord-329844-w969lczb 464 4 most most RBS cord-329844-w969lczb 464 5 appear appear VBP cord-329844-w969lczb 464 6 less less RBR cord-329844-w969lczb 464 7 directly directly RB cord-329844-w969lczb 464 8 relevant relevant JJ cord-329844-w969lczb 464 9 to to IN cord-329844-w969lczb 464 10 sugar sugar NN cord-329844-w969lczb 464 11 , , , cord-329844-w969lczb 464 12 but but CC cord-329844-w969lczb 464 13 many many JJ cord-329844-w969lczb 464 14 of of IN cord-329844-w969lczb 464 15 these these DT cord-329844-w969lczb 464 16 merit merit NN cord-329844-w969lczb 464 17 more more JJR cord-329844-w969lczb 464 18 examination examination NN cord-329844-w969lczb 464 19 . . . cord-329844-w969lczb 465 1 Details detail NNS cord-329844-w969lczb 465 2 of of IN cord-329844-w969lczb 465 3 each each DT cord-329844-w969lczb 465 4 case case NN cord-329844-w969lczb 465 5 are be VBP cord-329844-w969lczb 465 6 beyond beyond IN cord-329844-w969lczb 465 7 present present JJ cord-329844-w969lczb 465 8 scope scope NN cord-329844-w969lczb 465 9 , , , cord-329844-w969lczb 465 10 but but CC cord-329844-w969lczb 466 1 for for IN cord-329844-w969lczb 466 2 example example NN cord-329844-w969lczb 466 3 a a DT cord-329844-w969lczb 466 4 particularly particularly RB cord-329844-w969lczb 466 5 recurrent recurrent JJ cord-329844-w969lczb 466 6 match match NN cord-329844-w969lczb 466 7 example example NN cord-329844-w969lczb 466 8 is be VBZ cord-329844-w969lczb 466 9 SSSGWTAGA SSSGWTAGA NNP cord-329844-w969lczb 466 10 or or CC cord-329844-w969lczb 466 11 similar similar JJ cord-329844-w969lczb 466 12 sequences sequence NNS cord-329844-w969lczb 466 13 of of IN cord-329844-w969lczb 466 14 proteins protein NNS cord-329844-w969lczb 466 15 that that WDT cord-329844-w969lczb 466 16 contain contain VBP cord-329844-w969lczb 466 17 the the DT cord-329844-w969lczb 466 18 twin twin JJ cord-329844-w969lczb 466 19 - - HYPH cord-329844-w969lczb 466 20 arginine arginine NN cord-329844-w969lczb 466 21 translocation translocation NN cord-329844-w969lczb 466 22 pathway pathway NN cord-329844-w969lczb 466 23 signal signal NN cord-329844-w969lczb 466 24 of of IN cord-329844-w969lczb 466 25 most most JJS cord-329844-w969lczb 466 26 bacteria bacteria NNS cord-329844-w969lczb 466 27 and and CC cord-329844-w969lczb 466 28 archaea archaea NNS cord-329844-w969lczb 466 29 . . . cord-329844-w969lczb 467 1 For for IN cord-329844-w969lczb 467 2 example example NN cord-329844-w969lczb 467 3 such such JJ cord-329844-w969lczb 467 4 as as IN cord-329844-w969lczb 467 5 Ruegeria Ruegeria NNP cord-329844-w969lczb 467 6 marisrubri marisrubri NNP cord-329844-w969lczb 467 7 , , , cord-329844-w969lczb 467 8 of of IN cord-329844-w969lczb 467 9 the the DT cord-329844-w969lczb 467 10 Rhodobacteraceae Rhodobacteraceae NNP cord-329844-w969lczb 467 11 has have VBZ cord-329844-w969lczb 467 12 the the DT cord-329844-w969lczb 467 13 above above JJ cord-329844-w969lczb 467 14 matching match VBG cord-329844-w969lczb 467 15 subsequence subsequence NN cord-329844-w969lczb 467 16 . . . cord-329844-w969lczb 468 1 The the DT cord-329844-w969lczb 468 2 twin twin JJ cord-329844-w969lczb 468 3 - - HYPH cord-329844-w969lczb 468 4 arginine arginine NN cord-329844-w969lczb 468 5 translocation translocation NN cord-329844-w969lczb 468 6 pathway pathway NN cord-329844-w969lczb 468 7 transports transport NNS cord-329844-w969lczb 468 8 folded fold VBD cord-329844-w969lczb 468 9 proteins protein NNS cord-329844-w969lczb 468 10 across across IN cord-329844-w969lczb 468 11 the the DT cord-329844-w969lczb 468 12 cytoplasmic cytoplasmic JJ cord-329844-w969lczb 468 13 membrane membrane NN cord-329844-w969lczb 468 14 of of IN cord-329844-w969lczb 468 15 these these DT cord-329844-w969lczb 468 16 microorganisms microorganism NNS cord-329844-w969lczb 468 17 . . . cord-329844-w969lczb 469 1 The the DT cord-329844-w969lczb 469 2 proteins protein NNS cord-329844-w969lczb 469 3 are be VBP cord-329844-w969lczb 469 4 targeted target VBN cord-329844-w969lczb 469 5 by by IN cord-329844-w969lczb 469 6 signal signal NN cord-329844-w969lczb 469 7 peptides peptide NNS cord-329844-w969lczb 469 8 containing contain VBG cord-329844-w969lczb 469 9 a a DT cord-329844-w969lczb 469 10 conserved conserve VBN cord-329844-w969lczb 469 11 twin twin NN cord-329844-w969lczb 469 12 - - HYPH cord-329844-w969lczb 469 13 arginine arginine NN cord-329844-w969lczb 469 14 motif motif NN cord-329844-w969lczb 469 15 , , , cord-329844-w969lczb 469 16 and and CC cord-329844-w969lczb 469 17 the the DT cord-329844-w969lczb 469 18 literature literature NN cord-329844-w969lczb 469 19 does do VBZ cord-329844-w969lczb 469 20 not not RB cord-329844-w969lczb 469 21 always always RB cord-329844-w969lczb 469 22 mention mention VB cord-329844-w969lczb 469 23 any any DT cord-329844-w969lczb 469 24 N n NN cord-329844-w969lczb 469 25 - - HYPH cord-329844-w969lczb 469 26 glycosylation glycosylation NN cord-329844-w969lczb 469 27 and and CC cord-329844-w969lczb 469 28 indeed indeed RB cord-329844-w969lczb 469 29 there there EX cord-329844-w969lczb 469 30 may may MD cord-329844-w969lczb 469 31 not not RB cord-329844-w969lczb 469 32 in in IN cord-329844-w969lczb 469 33 every every DT cord-329844-w969lczb 469 34 case case NN cord-329844-w969lczb 469 35 be be VB cord-329844-w969lczb 469 36 any any DT cord-329844-w969lczb 469 37 directly directly RB cord-329844-w969lczb 469 38 relevant relevant JJ cord-329844-w969lczb 469 39 evidence evidence NN cord-329844-w969lczb 469 40 of of IN cord-329844-w969lczb 469 41 such such JJ cord-329844-w969lczb 469 42 . . . cord-329844-w969lczb 470 1 However however RB cord-329844-w969lczb 470 2 , , , cord-329844-w969lczb 470 3 there there EX cord-329844-w969lczb 470 4 is be VBZ cord-329844-w969lczb 470 5 certainly certainly RB cord-329844-w969lczb 470 6 known know VBN cord-329844-w969lczb 470 7 involvement involvement NN cord-329844-w969lczb 470 8 in in IN cord-329844-w969lczb 470 9 the the DT cord-329844-w969lczb 470 10 production production NN cord-329844-w969lczb 470 11 of of IN cord-329844-w969lczb 470 12 secretory secretory JJ cord-329844-w969lczb 470 13 and and CC cord-329844-w969lczb 470 14 extracellular extracellular JJ cord-329844-w969lczb 470 15 N n CD cord-329844-w969lczb 470 16 - - HYPH cord-329844-w969lczb 470 17 linked link VBN cord-329844-w969lczb 470 18 glycoproteins glycoprotein NNS cord-329844-w969lczb 470 19 in in IN cord-329844-w969lczb 470 20 bacteria bacteria NNS cord-329844-w969lczb 470 21 such such JJ cord-329844-w969lczb 470 22 as as IN cord-329844-w969lczb 470 23 Escherichia Escherichia NNP cord-329844-w969lczb 470 24 coli coli NNS cord-329844-w969lczb 470 25 . . . cord-329844-w969lczb 471 1 The the DT cord-329844-w969lczb 471 2 third third JJ cord-329844-w969lczb 471 3 predicted predict VBN cord-329844-w969lczb 471 4 subsequence subsequence NN cord-329844-w969lczb 471 5 is be VBZ cord-329844-w969lczb 471 6 HWKWPWYIWL HWKWPWYIWL NNP cord-329844-w969lczb 471 7 1102 1102 CD cord-329844-w969lczb 471 8 - - SYM cord-329844-w969lczb 471 9 1218 1218 CD cord-329844-w969lczb 471 10 with with IN cord-329844-w969lczb 471 11 a a DT cord-329844-w969lczb 471 12 peak peak NN cord-329844-w969lczb 471 13 score score NN cord-329844-w969lczb 471 14 of of IN cord-329844-w969lczb 471 15 108 108 CD cord-329844-w969lczb 471 16 relates relate NNS cord-329844-w969lczb 471 17 to to IN cord-329844-w969lczb 471 18 IKWPWYIWL IKWPWYIWL NNP cord-329844-w969lczb 471 19 in in IN cord-329844-w969lczb 471 20 the the DT cord-329844-w969lczb 471 21 original original JJ cord-329844-w969lczb 471 22 Wuhan Wuhan NNP cord-329844-w969lczb 471 23 seafood seafood NN cord-329844-w969lczb 471 24 market market NN cord-329844-w969lczb 471 25 isolate isolate NN cord-329844-w969lczb 471 26 ( ( -LRB- cord-329844-w969lczb 471 27 GenBank GenBank NNP cord-329844-w969lczb 471 28 MN908947.3 MN908947.3 NNP cord-329844-w969lczb 471 29 ) ) -RRB- cord-329844-w969lczb 471 30 and and CC cord-329844-w969lczb 471 31 lies lie VBZ cord-329844-w969lczb 471 32 at at IN cord-329844-w969lczb 471 33 the the DT cord-329844-w969lczb 471 34 boundary boundary NN cord-329844-w969lczb 471 35 between between IN cord-329844-w969lczb 471 36 the the DT cord-329844-w969lczb 471 37 C C NNP cord-329844-w969lczb 471 38 - - HYPH cord-329844-w969lczb 471 39 terminal terminal JJ cord-329844-w969lczb 471 40 end end NN cord-329844-w969lczb 471 41 of of IN cord-329844-w969lczb 471 42 S2 s2 NN cord-329844-w969lczb 471 43 and and CC cord-329844-w969lczb 471 44 the the DT cord-329844-w969lczb 471 45 transmembrane transmembrane NN cord-329844-w969lczb 471 46 part part NN cord-329844-w969lczb 471 47 1214 1214 CD cord-329844-w969lczb 471 48 - - SYM cord-329844-w969lczb 471 49 1273 1273 CD cord-329844-w969lczb 471 50 . . . cord-329844-w969lczb 472 1 Its -PRON- PRP$ cord-329844-w969lczb 472 2 3D 3d JJ cord-329844-w969lczb 472 3 structure structure NN cord-329844-w969lczb 472 4 is be VBZ cord-329844-w969lczb 472 5 not not RB cord-329844-w969lczb 472 6 , , , cord-329844-w969lczb 472 7 to to IN cord-329844-w969lczb 472 8 the the DT cord-329844-w969lczb 472 9 present present JJ cord-329844-w969lczb 472 10 author author NN cord-329844-w969lczb 472 11 's 's POS cord-329844-w969lczb 472 12 knowledge knowledge NN cord-329844-w969lczb 472 13 , , , cord-329844-w969lczb 472 14 available available JJ cord-329844-w969lczb 472 15 , , , cord-329844-w969lczb 472 16 as as IN cord-329844-w969lczb 472 17 it -PRON- PRP cord-329844-w969lczb 472 18 lies lie VBZ cord-329844-w969lczb 472 19 in in IN cord-329844-w969lczb 472 20 residues residue NNS cord-329844-w969lczb 472 21 1147 1147 CD cord-329844-w969lczb 472 22 onward onward RB cord-329844-w969lczb 472 23 are be VBP cord-329844-w969lczb 472 24 generally generally RB cord-329844-w969lczb 472 25 excluded exclude VBN cord-329844-w969lczb 472 26 from from IN cord-329844-w969lczb 472 27 experimental experimental JJ cord-329844-w969lczb 472 28 structure structure NN cord-329844-w969lczb 472 29 ( ( -LRB- cord-329844-w969lczb 472 30 e.g. e.g. RB cord-329844-w969lczb 472 31 VVX VVX NNP cord-329844-w969lczb 472 32 and and CC cord-329844-w969lczb 472 33 VYB VYB NNP cord-329844-w969lczb 472 34 ) ) -RRB- cord-329844-w969lczb 472 35 . . . cord-329844-w969lczb 473 1 Again again RB cord-329844-w969lczb 473 2 , , , cord-329844-w969lczb 473 3 matches match NNS cord-329844-w969lczb 473 4 with with IN cord-329844-w969lczb 473 5 non non JJ cord-329844-w969lczb 473 6 - - JJ cord-329844-w969lczb 473 7 virus virus JJ cord-329844-w969lczb 473 8 or or CC cord-329844-w969lczb 473 9 host host NN cord-329844-w969lczb 473 10 proteins protein NNS cord-329844-w969lczb 473 11 may may MD cord-329844-w969lczb 473 12 be be VB cord-329844-w969lczb 473 13 of of IN cord-329844-w969lczb 473 14 interest interest NN cord-329844-w969lczb 473 15 as as RB cord-329844-w969lczb 473 16 biologically biologically RB cord-329844-w969lczb 473 17 and and CC cord-329844-w969lczb 473 18 medically medically RB cord-329844-w969lczb 473 19 important important JJ cord-329844-w969lczb 473 20 . . . cord-329844-w969lczb 474 1 BLASTp BLASTp NNP cord-329844-w969lczb 474 2 searches search VBZ cord-329844-w969lczb 474 3 on on IN cord-329844-w969lczb 474 4 non non NNS cord-329844-w969lczb 474 5 - - NNS cord-329844-w969lczb 474 6 viruses virus NNS cord-329844-w969lczb 474 7 with with IN cord-329844-w969lczb 474 8 the the DT cord-329844-w969lczb 474 9 sequence sequence NN cord-329844-w969lczb 474 10 as as IN cord-329844-w969lczb 474 11 query query NN cord-329844-w969lczb 474 12 inappropriately inappropriately RB cord-329844-w969lczb 474 13 pick pick VB cord-329844-w969lczb 474 14 up up RP cord-329844-w969lczb 474 15 a a DT cord-329844-w969lczb 474 16 lot lot NN cord-329844-w969lczb 474 17 of of IN cord-329844-w969lczb 474 18 coronaviruses coronaviruse NNS cord-329844-w969lczb 474 19 by by IN cord-329844-w969lczb 474 20 accidentally accidentally RB cord-329844-w969lczb 474 21 relating relate VBG cord-329844-w969lczb 474 22 to to IN cord-329844-w969lczb 474 23 the the DT cord-329844-w969lczb 474 24 host host NN cord-329844-w969lczb 474 25 name name NN cord-329844-w969lczb 474 26 , , , cord-329844-w969lczb 474 27 but but CC cord-329844-w969lczb 474 28 this this DT cord-329844-w969lczb 474 29 is be VBZ cord-329844-w969lczb 474 30 indicative indicative JJ cord-329844-w969lczb 474 31 of of IN cord-329844-w969lczb 474 32 a a DT cord-329844-w969lczb 474 33 strong strong JJ cord-329844-w969lczb 474 34 recurrence recurrence NN cord-329844-w969lczb 474 35 of of IN cord-329844-w969lczb 474 36 the the DT cord-329844-w969lczb 474 37 motif motif NN cord-329844-w969lczb 474 38 across across IN cord-329844-w969lczb 474 39 coronaviruses coronaviruse NNS cord-329844-w969lczb 474 40 . . . cord-329844-w969lczb 475 1 Otherwise otherwise RB cord-329844-w969lczb 475 2 , , , cord-329844-w969lczb 475 3 there there EX cord-329844-w969lczb 475 4 is be VBZ cord-329844-w969lczb 475 5 a a DT cord-329844-w969lczb 475 6 diverse diverse JJ cord-329844-w969lczb 475 7 set set NN cord-329844-w969lczb 475 8 of of IN cord-329844-w969lczb 475 9 matches match NNS cord-329844-w969lczb 475 10 especially especially RB cord-329844-w969lczb 475 11 but but CC cord-329844-w969lczb 475 12 not not RB cord-329844-w969lczb 475 13 solely solely RB cord-329844-w969lczb 475 14 with with IN cord-329844-w969lczb 475 15 bacterial bacterial JJ cord-329844-w969lczb 475 16 proteins protein NNS cord-329844-w969lczb 475 17 , , , cord-329844-w969lczb 475 18 and and CC cord-329844-w969lczb 475 19 unfortunately unfortunately RB cord-329844-w969lczb 475 20 most most JJS cord-329844-w969lczb 475 21 are be VBP cord-329844-w969lczb 475 22 described describe VBN cord-329844-w969lczb 475 23 as as IN cord-329844-w969lczb 475 24 hypothetical hypothetical JJ cord-329844-w969lczb 475 25 proteins protein NNS cord-329844-w969lczb 475 26 for for IN cord-329844-w969lczb 475 27 which which WDT cord-329844-w969lczb 475 28 the the DT cord-329844-w969lczb 475 29 function function NN cord-329844-w969lczb 475 30 is be VBZ cord-329844-w969lczb 475 31 typically typically RB cord-329844-w969lczb 475 32 unclear unclear JJ cord-329844-w969lczb 475 33 . . . cord-329844-w969lczb 476 1 Of of IN cord-329844-w969lczb 476 2 those those DT cord-329844-w969lczb 476 3 that that WDT cord-329844-w969lczb 476 4 are be VBP cord-329844-w969lczb 476 5 named name VBN cord-329844-w969lczb 476 6 , , , cord-329844-w969lczb 476 7 there there EX cord-329844-w969lczb 476 8 are be VBP cord-329844-w969lczb 476 9 some some DT cord-329844-w969lczb 476 10 indications indication NNS cord-329844-w969lczb 476 11 of of IN cord-329844-w969lczb 476 12 involvements involvement NNS cord-329844-w969lczb 476 13 with with IN cord-329844-w969lczb 476 14 sugar sugar NN cord-329844-w969lczb 476 15 binding bind VBG cord-329844-w969lczb 476 16 in in IN cord-329844-w969lczb 476 17 many many JJ cord-329844-w969lczb 476 18 cases case NNS cord-329844-w969lczb 476 19 . . . cord-329844-w969lczb 477 1 Many many JJ cord-329844-w969lczb 477 2 are be VBP cord-329844-w969lczb 477 3 ribosome ribosome NN cord-329844-w969lczb 477 4 proteins protein NNS cord-329844-w969lczb 477 5 or or CC cord-329844-w969lczb 477 6 phosphatases phosphatase NNS cord-329844-w969lczb 477 7 relevant relevant JJ cord-329844-w969lczb 477 8 directly directly RB cord-329844-w969lczb 477 9 or or CC cord-329844-w969lczb 477 10 indirectly indirectly RB cord-329844-w969lczb 477 11 to to IN cord-329844-w969lczb 477 12 RNA RNA NNP cord-329844-w969lczb 477 13 or or CC cord-329844-w969lczb 477 14 ribose ribose NN cord-329844-w969lczb 477 15 binding binding NN cord-329844-w969lczb 477 16 . . . cord-329844-w969lczb 478 1 The the DT cord-329844-w969lczb 478 2 PAP2 PAP2 NNP cord-329844-w969lczb 478 3 superfamily superfamily NN cord-329844-w969lczb 478 4 is be VBZ cord-329844-w969lczb 478 5 characterized characterize VBN cord-329844-w969lczb 478 6 by by IN cord-329844-w969lczb 478 7 a a DT cord-329844-w969lczb 478 8 core core NN cord-329844-w969lczb 478 9 consisting consist VBG cord-329844-w969lczb 478 10 of of IN cord-329844-w969lczb 478 11 a a DT cord-329844-w969lczb 478 12 5-helical 5-helical CD cord-329844-w969lczb 478 13 bundle bundle NN cord-329844-w969lczb 478 14 and and CC cord-329844-w969lczb 478 15 includes include VBZ cord-329844-w969lczb 478 16 functions function NNS cord-329844-w969lczb 478 17 involving involve VBG cord-329844-w969lczb 478 18 glycerol glycerol NN cord-329844-w969lczb 478 19 phosphates phosphate NNS cord-329844-w969lczb 478 20 but but CC cord-329844-w969lczb 478 21 also also RB cord-329844-w969lczb 478 22 sugars sugar VBZ cord-329844-w969lczb 478 23 such such JJ cord-329844-w969lczb 478 24 as as IN cord-329844-w969lczb 478 25 in in IN cord-329844-w969lczb 478 26 the the DT cord-329844-w969lczb 478 27 case case NN cord-329844-w969lczb 478 28 of of IN cord-329844-w969lczb 478 29 Glucose-6-phosphatase Glucose-6-phosphatase NNP cord-329844-w969lczb 478 30 . . . cord-329844-w969lczb 479 1 This this DT cord-329844-w969lczb 479 2 subsequence subsequence NN cord-329844-w969lczb 479 3 HWKWPWYIWL HWKWPWYIWL NNP cord-329844-w969lczb 479 4 also also RB cord-329844-w969lczb 479 5 matches match VBZ cord-329844-w969lczb 479 6 sequences sequence NNS cord-329844-w969lczb 479 7 in in IN cord-329844-w969lczb 479 8 proteins protein NNS cord-329844-w969lczb 479 9 with with IN cord-329844-w969lczb 479 10 an an DT cord-329844-w969lczb 479 11 SPFH SPFH NNP cord-329844-w969lczb 479 12 domain domain NN cord-329844-w969lczb 479 13 which which WDT cord-329844-w969lczb 479 14 is be VBZ cord-329844-w969lczb 479 15 implicated implicate VBN cord-329844-w969lczb 479 16 in in IN cord-329844-w969lczb 479 17 regulating regulate VBG cord-329844-w969lczb 479 18 targeted target VBN cord-329844-w969lczb 479 19 protein protein NN cord-329844-w969lczb 479 20 turnover turnover NN cord-329844-w969lczb 479 21 in in IN cord-329844-w969lczb 479 22 stomatins stomatin NNS cord-329844-w969lczb 479 23 and and CC cord-329844-w969lczb 479 24 other other JJ cord-329844-w969lczb 479 25 membrane membrane NN cord-329844-w969lczb 479 26 - - HYPH cord-329844-w969lczb 479 27 associated associate VBN cord-329844-w969lczb 479 28 proteins protein NNS cord-329844-w969lczb 479 29 . . . cord-329844-w969lczb 480 1 HWKWPWYIWL HWKWPWYIWL NNP cord-329844-w969lczb 480 2 has have VBZ cord-329844-w969lczb 480 3 of of IN cord-329844-w969lczb 480 4 course course NN cord-329844-w969lczb 480 5 a a DT cord-329844-w969lczb 480 6 notable notable JJ cord-329844-w969lczb 480 7 tryptophan tryptophan NN cord-329844-w969lczb 480 8 ( ( -LRB- cord-329844-w969lczb 480 9 W w NN cord-329844-w969lczb 480 10 ) ) -RRB- cord-329844-w969lczb 480 11 repeat repeat VB cord-329844-w969lczb 480 12 that that WDT cord-329844-w969lczb 480 13 hints hint VBZ cord-329844-w969lczb 480 14 a a DT cord-329844-w969lczb 480 15 special special JJ cord-329844-w969lczb 480 16 role role NN cord-329844-w969lczb 480 17 of of IN cord-329844-w969lczb 480 18 its -PRON- PRP$ cord-329844-w969lczb 480 19 own own JJ cord-329844-w969lczb 480 20 , , , cord-329844-w969lczb 480 21 certainly certainly RB cord-329844-w969lczb 480 22 worthy worthy JJ cord-329844-w969lczb 480 23 of of IN cord-329844-w969lczb 480 24 analysis analysis NN cord-329844-w969lczb 480 25 but but CC cord-329844-w969lczb 480 26 outside outside JJ cord-329844-w969lczb 480 27 present present JJ cord-329844-w969lczb 480 28 scope scope NN cord-329844-w969lczb 480 29 . . . cord-329844-w969lczb 481 1 In in IN cord-329844-w969lczb 481 2 general general JJ cord-329844-w969lczb 481 3 , , , cord-329844-w969lczb 481 4 however however RB cord-329844-w969lczb 481 5 , , , cord-329844-w969lczb 481 6 it -PRON- PRP cord-329844-w969lczb 481 7 does do VBZ cord-329844-w969lczb 481 8 appear appear VB cord-329844-w969lczb 481 9 that that IN cord-329844-w969lczb 481 10 across across IN cord-329844-w969lczb 481 11 many many JJ cord-329844-w969lczb 481 12 proteins protein NNS cord-329844-w969lczb 481 13 it -PRON- PRP cord-329844-w969lczb 481 14 has have VBZ cord-329844-w969lczb 481 15 other other JJ cord-329844-w969lczb 481 16 functions function NNS cord-329844-w969lczb 481 17 than than IN cord-329844-w969lczb 481 18 sugar sugar NN cord-329844-w969lczb 481 19 binding binding NN cord-329844-w969lczb 481 20 ( ( -LRB- cord-329844-w969lczb 481 21 perhaps perhaps RB cord-329844-w969lczb 481 22 diverse diverse JJ cord-329844-w969lczb 481 23 or or CC cord-329844-w969lczb 481 24 multiple multiple JJ cord-329844-w969lczb 481 25 functions function NNS cord-329844-w969lczb 481 26 ) ) -RRB- cord-329844-w969lczb 481 27 , , , cord-329844-w969lczb 481 28 although although IN cord-329844-w969lczb 481 29 sugar sugar NN cord-329844-w969lczb 481 30 binding binding NN cord-329844-w969lczb 481 31 is be VBZ cord-329844-w969lczb 481 32 not not RB cord-329844-w969lczb 481 33 excluded exclude VBN cord-329844-w969lczb 481 34 . . . cord-329844-w969lczb 482 1 The the DT cord-329844-w969lczb 482 2 significance significance NN cord-329844-w969lczb 482 3 and and CC cord-329844-w969lczb 482 4 innovation innovation NN cord-329844-w969lczb 482 5 of of IN cord-329844-w969lczb 482 6 the the DT cord-329844-w969lczb 482 7 present present JJ cord-329844-w969lczb 482 8 work work NN cord-329844-w969lczb 482 9 is be VBZ cord-329844-w969lczb 482 10 that that IN cord-329844-w969lczb 482 11 it -PRON- PRP cord-329844-w969lczb 482 12 proposes propose VBZ cord-329844-w969lczb 482 13 a a DT cord-329844-w969lczb 482 14 sialic sialic JJ cord-329844-w969lczb 482 15 acid acid NN cord-329844-w969lczb 482 16 glycan glycan NN cord-329844-w969lczb 482 17 binding binding NN cord-329844-w969lczb 482 18 function function NN cord-329844-w969lczb 482 19 for for IN cord-329844-w969lczb 482 20 the the DT cord-329844-w969lczb 482 21 SARS SARS NNP cord-329844-w969lczb 482 22 - - HYPH cord-329844-w969lczb 482 23 CoV-2 CoV-2 NNP cord-329844-w969lczb 482 24 spike spike NN cord-329844-w969lczb 482 25 protein protein NN cord-329844-w969lczb 482 26 that that WDT cord-329844-w969lczb 482 27 has have VBZ cord-329844-w969lczb 482 28 been be VBN cord-329844-w969lczb 482 29 largely largely RB cord-329844-w969lczb 482 30 neglected neglect VBN cord-329844-w969lczb 482 31 by by IN cord-329844-w969lczb 482 32 other other JJ cord-329844-w969lczb 482 33 workers worker NNS cord-329844-w969lczb 482 34 , , , cord-329844-w969lczb 482 35 apparently apparently RB cord-329844-w969lczb 482 36 on on IN cord-329844-w969lczb 482 37 the the DT cord-329844-w969lczb 482 38 rationale rationale NN cord-329844-w969lczb 482 39 that that WDT cord-329844-w969lczb 482 40 ACE-2 ACE-2 NNP cord-329844-w969lczb 482 41 binding binding NN cord-329844-w969lczb 482 42 is be VBZ cord-329844-w969lczb 482 43 the the DT cord-329844-w969lczb 482 44 important important JJ cord-329844-w969lczb 482 45 first first JJ cord-329844-w969lczb 482 46 step step NN cord-329844-w969lczb 482 47 in in IN cord-329844-w969lczb 482 48 cell cell NN cord-329844-w969lczb 482 49 entry entry NN cord-329844-w969lczb 482 50 . . . cord-329844-w969lczb 483 1 Sites site NNS cord-329844-w969lczb 483 2 involved involve VBN cord-329844-w969lczb 483 3 in in IN cord-329844-w969lczb 483 4 the the DT cord-329844-w969lczb 483 5 characteristic characteristic JJ cord-329844-w969lczb 483 6 cap cap NN cord-329844-w969lczb 483 7 or or CC cord-329844-w969lczb 483 8 knob knob NN cord-329844-w969lczb 483 9 of of IN cord-329844-w969lczb 483 10 the the DT cord-329844-w969lczb 483 11 spike spike NN cord-329844-w969lczb 483 12 protein protein NN cord-329844-w969lczb 483 13 appear appear VBP cord-329844-w969lczb 483 14 partially partially RB cord-329844-w969lczb 483 15 persuasive persuasive JJ cord-329844-w969lczb 483 16 in in IN cord-329844-w969lczb 483 17 the the DT cord-329844-w969lczb 483 18 light light NN cord-329844-w969lczb 483 19 of of IN cord-329844-w969lczb 483 20 their -PRON- PRP$ cord-329844-w969lczb 483 21 role role NN cord-329844-w969lczb 483 22 as as IN cord-329844-w969lczb 483 23 binding bind VBG cord-329844-w969lczb 483 24 to to IN cord-329844-w969lczb 483 25 host host NN cord-329844-w969lczb 483 26 cells cell NNS cord-329844-w969lczb 483 27 . . . cord-329844-w969lczb 484 1 There there EX cord-329844-w969lczb 484 2 is be VBZ cord-329844-w969lczb 484 3 a a DT cord-329844-w969lczb 484 4 further further JJ cord-329844-w969lczb 484 5 possible possible JJ cord-329844-w969lczb 484 6 site site NN cord-329844-w969lczb 484 7 towards towards IN cord-329844-w969lczb 484 8 the the DT cord-329844-w969lczb 484 9 base base NN cord-329844-w969lczb 484 10 of of IN cord-329844-w969lczb 484 11 the the DT cord-329844-w969lczb 484 12 external external JJ cord-329844-w969lczb 484 13 part part NN cord-329844-w969lczb 484 14 of of IN cord-329844-w969lczb 484 15 the the DT cord-329844-w969lczb 484 16 spike spike NN cord-329844-w969lczb 484 17 protein protein NN cord-329844-w969lczb 484 18 , , , cord-329844-w969lczb 484 19 which which WDT cord-329844-w969lczb 484 20 seems seem VBZ cord-329844-w969lczb 484 21 less less RBR cord-329844-w969lczb 484 22 likely likely JJ cord-329844-w969lczb 484 23 by by IN cord-329844-w969lczb 484 24 virtue virtue NN cord-329844-w969lczb 484 25 of of IN cord-329844-w969lczb 484 26 its -PRON- PRP$ cord-329844-w969lczb 484 27 position position NN cord-329844-w969lczb 484 28 and and CC cord-329844-w969lczb 484 29 weaker weak JJR cord-329844-w969lczb 484 30 prediction prediction NN cord-329844-w969lczb 484 31 . . . cord-329844-w969lczb 485 1 Interaction interaction NN cord-329844-w969lczb 485 2 with with IN cord-329844-w969lczb 485 3 sialic sialic JJ cord-329844-w969lczb 485 4 acid acid NN cord-329844-w969lczb 485 5 glycan glycan NN cord-329844-w969lczb 485 6 with with IN cord-329844-w969lczb 485 7 or or CC cord-329844-w969lczb 485 8 without without IN cord-329844-w969lczb 485 9 associated associated JJ cord-329844-w969lczb 485 10 catalytic catalytic JJ cord-329844-w969lczb 485 11 activity activity NN cord-329844-w969lczb 485 12 would would MD cord-329844-w969lczb 485 13 be be VB cord-329844-w969lczb 485 14 consistent consistent JJ cord-329844-w969lczb 485 15 with with IN cord-329844-w969lczb 485 16 such such JJ cord-329844-w969lczb 485 17 functions function NNS cord-329844-w969lczb 485 18 observed observe VBN cord-329844-w969lczb 485 19 in in IN cord-329844-w969lczb 485 20 many many JJ cord-329844-w969lczb 485 21 respiratory respiratory JJ cord-329844-w969lczb 485 22 and and CC cord-329844-w969lczb 485 23 alimentary alimentary JJ cord-329844-w969lczb 485 24 tract tract NN cord-329844-w969lczb 485 25 viruses virus NNS cord-329844-w969lczb 485 26 , , , cord-329844-w969lczb 485 27 and and CC cord-329844-w969lczb 485 28 not not RB cord-329844-w969lczb 485 29 least least JJS cord-329844-w969lczb 485 30 in in IN cord-329844-w969lczb 485 31 many many JJ cord-329844-w969lczb 485 32 or or CC cord-329844-w969lczb 485 33 most most JJS cord-329844-w969lczb 485 34 other other JJ cord-329844-w969lczb 485 35 coronaviruses coronaviruse NNS cord-329844-w969lczb 485 36 , , , cord-329844-w969lczb 485 37 and and CC cord-329844-w969lczb 485 38 so so RB cord-329844-w969lczb 485 39 such such PDT cord-329844-w969lczb 485 40 a a DT cord-329844-w969lczb 485 41 function function NN cord-329844-w969lczb 485 42 must must MD cord-329844-w969lczb 485 43 be be VB cord-329844-w969lczb 485 44 important important JJ cord-329844-w969lczb 485 45 to to IN cord-329844-w969lczb 485 46 these these DT cord-329844-w969lczb 485 47 viruses virus NNS cord-329844-w969lczb 485 48 . . . cord-329844-w969lczb 486 1 On on IN cord-329844-w969lczb 486 2 these these DT cord-329844-w969lczb 486 3 grounds ground NNS cord-329844-w969lczb 486 4 , , , cord-329844-w969lczb 486 5 it -PRON- PRP cord-329844-w969lczb 486 6 may may MD cord-329844-w969lczb 486 7 be be VB cord-329844-w969lczb 486 8 a a DT cord-329844-w969lczb 486 9 target target NN cord-329844-w969lczb 486 10 for for IN cord-329844-w969lczb 486 11 therapeutic therapeutic JJ cord-329844-w969lczb 486 12 agents agent NNS cord-329844-w969lczb 486 13 against against IN cord-329844-w969lczb 486 14 SARS SARS NNP cord-329844-w969lczb 486 15 - - HYPH cord-329844-w969lczb 486 16 CoV-2 CoV-2 NNP cord-329844-w969lczb 486 17 , , , cord-329844-w969lczb 486 18 particularly particularly RB cord-329844-w969lczb 486 19 perhaps perhaps RB cord-329844-w969lczb 486 20 preventatives preventative NNS cord-329844-w969lczb 486 21 as as RB cord-329844-w969lczb 486 22 well well RB cord-329844-w969lczb 486 23 as as IN cord-329844-w969lczb 486 24 means mean NNS cord-329844-w969lczb 486 25 of of IN cord-329844-w969lczb 486 26 impeding impede VBG cord-329844-w969lczb 486 27 spread spread NN cord-329844-w969lczb 486 28 from from IN cord-329844-w969lczb 486 29 lung lung NN cord-329844-w969lczb 486 30 cell cell NN cord-329844-w969lczb 486 31 to to IN cord-329844-w969lczb 486 32 lung lung NN cord-329844-w969lczb 486 33 cell cell NN cord-329844-w969lczb 486 34 , , , cord-329844-w969lczb 486 35 and and CC cord-329844-w969lczb 486 36 an an DT cord-329844-w969lczb 486 37 exposed expose VBN cord-329844-w969lczb 486 38 target target NN cord-329844-w969lczb 486 39 for for IN cord-329844-w969lczb 486 40 antibodies antibody NNS cord-329844-w969lczb 486 41 raised raise VBN cord-329844-w969lczb 486 42 by by IN cord-329844-w969lczb 486 43 synthetic synthetic JJ cord-329844-w969lczb 486 44 vaccines vaccine NNS cord-329844-w969lczb 486 45 . . . cord-329844-w969lczb 487 1 Although although IN cord-329844-w969lczb 487 2 other other JJ cord-329844-w969lczb 487 3 authors author NNS cord-329844-w969lczb 487 4 have have VBP cord-329844-w969lczb 487 5 recently recently RB cord-329844-w969lczb 487 6 touched touch VBN cord-329844-w969lczb 487 7 on on IN cord-329844-w969lczb 487 8 such such PDT cord-329844-w969lczb 487 9 a a DT cord-329844-w969lczb 487 10 glycan glycan NN cord-329844-w969lczb 487 11 binding bind VBG cord-329844-w969lczb 487 12 ability ability NN cord-329844-w969lczb 487 13 in in IN cord-329844-w969lczb 487 14 SARS SARS NNP cord-329844-w969lczb 487 15 ( ( -LRB- cord-329844-w969lczb 487 16 as as IN cord-329844-w969lczb 487 17 discussed discuss VBN cord-329844-w969lczb 487 18 in in IN cord-329844-w969lczb 487 19 this this DT cord-329844-w969lczb 487 20 paper paper NN cord-329844-w969lczb 487 21 above above RB cord-329844-w969lczb 487 22 and and CC cord-329844-w969lczb 487 23 particularly particularly RB cord-329844-w969lczb 487 24 below below RB cord-329844-w969lczb 487 25 ) ) -RRB- cord-329844-w969lczb 487 26 , , , cord-329844-w969lczb 487 27 it -PRON- PRP cord-329844-w969lczb 487 28 has have VBZ cord-329844-w969lczb 487 29 not not RB cord-329844-w969lczb 487 30 been be VBN cord-329844-w969lczb 487 31 to to IN cord-329844-w969lczb 487 32 the the DT cord-329844-w969lczb 487 33 present present JJ cord-329844-w969lczb 487 34 author author NN cord-329844-w969lczb 487 35 's 's POS cord-329844-w969lczb 487 36 knowledge knowledge NN cord-329844-w969lczb 487 37 analyzed analyze VBN cord-329844-w969lczb 487 38 in in IN cord-329844-w969lczb 487 39 comparable comparable JJ cord-329844-w969lczb 487 40 detail detail NN cord-329844-w969lczb 487 41 and and CC cord-329844-w969lczb 487 42 do do VBP cord-329844-w969lczb 487 43 not not RB cord-329844-w969lczb 487 44 appear appear VB cord-329844-w969lczb 487 45 to to TO cord-329844-w969lczb 487 46 relate relate VB cord-329844-w969lczb 487 47 to to IN cord-329844-w969lczb 487 48 the the DT cord-329844-w969lczb 487 49 same same JJ cord-329844-w969lczb 487 50 site site NN cord-329844-w969lczb 487 51 . . . cord-329844-w969lczb 488 1 Nor nor CC cord-329844-w969lczb 488 2 do do VBP cord-329844-w969lczb 488 3 they -PRON- PRP cord-329844-w969lczb 488 4 propose propose VB cord-329844-w969lczb 488 5 a a DT cord-329844-w969lczb 488 6 general general JJ cord-329844-w969lczb 488 7 prediction prediction NN cord-329844-w969lczb 488 8 method method NN cord-329844-w969lczb 488 9 for for IN cord-329844-w969lczb 488 10 sialic sialic JJ cord-329844-w969lczb 488 11 acid acid NN cord-329844-w969lczb 488 12 glycan glycan NN cord-329844-w969lczb 488 13 binding binding NN cord-329844-w969lczb 488 14 as as IN cord-329844-w969lczb 488 15 described describe VBN cord-329844-w969lczb 488 16 in in IN cord-329844-w969lczb 488 17 the the DT cord-329844-w969lczb 488 18 present present JJ cord-329844-w969lczb 488 19 paper paper NN cord-329844-w969lczb 488 20 . . . cord-329844-w969lczb 489 1 Of of RB cord-329844-w969lczb 489 2 course course RB cord-329844-w969lczb 489 3 , , , cord-329844-w969lczb 489 4 in in IN cord-329844-w969lczb 489 5 the the DT cord-329844-w969lczb 489 6 present present JJ cord-329844-w969lczb 489 7 paper paper NN cord-329844-w969lczb 489 8 this this DT cord-329844-w969lczb 489 9 is be VBZ cord-329844-w969lczb 489 10 still still RB cord-329844-w969lczb 489 11 a a DT cord-329844-w969lczb 489 12 prediction prediction NN cord-329844-w969lczb 489 13 and and CC cord-329844-w969lczb 489 14 not not RB cord-329844-w969lczb 489 15 an an DT cord-329844-w969lczb 489 16 experimental experimental JJ cord-329844-w969lczb 489 17 result result NN cord-329844-w969lczb 489 18 , , , cord-329844-w969lczb 489 19 but but CC cord-329844-w969lczb 489 20 it -PRON- PRP cord-329844-w969lczb 489 21 will will MD cord-329844-w969lczb 489 22 hopefully hopefully RB cord-329844-w969lczb 489 23 encourage encourage VB cord-329844-w969lczb 489 24 experimental experimental JJ cord-329844-w969lczb 489 25 researchers researcher NNS cord-329844-w969lczb 489 26 to to TO cord-329844-w969lczb 489 27 investigate investigate VB cord-329844-w969lczb 489 28 the the DT cord-329844-w969lczb 489 29 glycan glycan NN cord-329844-w969lczb 489 30 binding bind VBG cord-329844-w969lczb 489 31 properties property NNS cord-329844-w969lczb 489 32 of of IN cord-329844-w969lczb 489 33 SARS SARS NNP cord-329844-w969lczb 489 34 - - : cord-329844-w969lczb 489 35 CoV-2 CoV-2 NNP cord-329844-w969lczb 489 36 more more RBR cord-329844-w969lczb 489 37 extensively extensively RB cord-329844-w969lczb 489 38 . . . cord-329844-w969lczb 490 1 A a DT cord-329844-w969lczb 490 2 further further JJ cord-329844-w969lczb 490 3 innovative innovative JJ cord-329844-w969lczb 490 4 feature feature NN cord-329844-w969lczb 490 5 is be VBZ cord-329844-w969lczb 490 6 that that DT cord-329844-w969lczb 490 7 predictive predictive JJ cord-329844-w969lczb 490 8 method method NN cord-329844-w969lczb 490 9 , , , cord-329844-w969lczb 490 10 which which WDT cord-329844-w969lczb 490 11 is be VBZ cord-329844-w969lczb 490 12 expected expect VBN cord-329844-w969lczb 490 13 to to TO cord-329844-w969lczb 490 14 be be VB cord-329844-w969lczb 490 15 worthy worthy JJ cord-329844-w969lczb 490 16 of of IN cord-329844-w969lczb 490 17 investigation investigation NN cord-329844-w969lczb 490 18 for for IN cord-329844-w969lczb 490 19 the the DT cord-329844-w969lczb 490 20 proteins protein NNS cord-329844-w969lczb 490 21 of of IN cord-329844-w969lczb 490 22 other other JJ cord-329844-w969lczb 490 23 viruses virus NNS cord-329844-w969lczb 490 24 and and CC cord-329844-w969lczb 490 25 even even RB cord-329844-w969lczb 490 26 of of IN cord-329844-w969lczb 490 27 other other JJ cord-329844-w969lczb 490 28 organisms organism NNS cord-329844-w969lczb 490 29 . . . cord-329844-w969lczb 491 1 Like like IN cord-329844-w969lczb 491 2 many many JJ cord-329844-w969lczb 491 3 predictive predictive JJ cord-329844-w969lczb 491 4 methods method NNS cord-329844-w969lczb 491 5 in in IN cord-329844-w969lczb 491 6 bioinformatics bioinformatic NNS cord-329844-w969lczb 491 7 it -PRON- PRP cord-329844-w969lczb 491 8 is be VBZ cord-329844-w969lczb 491 9 not not RB cord-329844-w969lczb 491 10 perfect perfect JJ cord-329844-w969lczb 491 11 , , , cord-329844-w969lczb 491 12 i.e. i.e. FW cord-329844-w969lczb 491 13 there there EX cord-329844-w969lczb 491 14 are be VBP cord-329844-w969lczb 491 15 false false JJ cord-329844-w969lczb 491 16 positives positive NNS cord-329844-w969lczb 491 17 and and CC cord-329844-w969lczb 491 18 false false JJ cord-329844-w969lczb 491 19 negatives negative NNS cord-329844-w969lczb 491 20 in in IN cord-329844-w969lczb 491 21 prediction prediction NN cord-329844-w969lczb 491 22 , , , cord-329844-w969lczb 491 23 so so CC cord-329844-w969lczb 491 24 it -PRON- PRP cord-329844-w969lczb 491 25 is be VBZ cord-329844-w969lczb 491 26 actually actually RB cord-329844-w969lczb 491 27 conceivable conceivable JJ cord-329844-w969lczb 491 28 that that IN cord-329844-w969lczb 491 29 the the DT cord-329844-w969lczb 491 30 method method NN cord-329844-w969lczb 491 31 is be VBZ cord-329844-w969lczb 491 32 useful useful JJ cord-329844-w969lczb 491 33 even even RB cord-329844-w969lczb 491 34 if if IN cord-329844-w969lczb 491 35 it -PRON- PRP cord-329844-w969lczb 491 36 is be VBZ cord-329844-w969lczb 491 37 not not RB cord-329844-w969lczb 491 38 correct correct JJ cord-329844-w969lczb 491 39 in in IN cord-329844-w969lczb 491 40 the the DT cord-329844-w969lczb 491 41 particular particular JJ cord-329844-w969lczb 491 42 case case NN cord-329844-w969lczb 491 43 of of IN cord-329844-w969lczb 491 44 SARS SARS NNP cord-329844-w969lczb 491 45 - - HYPH cord-329844-w969lczb 491 46 CoV-2 CoV-2 NNP cord-329844-w969lczb 491 47 . . . cord-329844-w969lczb 492 1 In in IN cord-329844-w969lczb 492 2 that that DT cord-329844-w969lczb 492 3 sense sense NN cord-329844-w969lczb 492 4 , , , cord-329844-w969lczb 492 5 it -PRON- PRP cord-329844-w969lczb 492 6 may may MD cord-329844-w969lczb 492 7 emerge emerge VB cord-329844-w969lczb 492 8 as as IN cord-329844-w969lczb 492 9 the the DT cord-329844-w969lczb 492 10 more more RBR cord-329844-w969lczb 492 11 important important JJ cord-329844-w969lczb 492 12 contribution contribution NN cord-329844-w969lczb 492 13 . . . cord-329844-w969lczb 493 1 Work work VB cord-329844-w969lczb 493 2 . . . cord-329844-w969lczb 494 1 The the DT cord-329844-w969lczb 494 2 current current JJ cord-329844-w969lczb 494 3 SABR SABR NNP cord-329844-w969lczb 494 4 - - HYPH cord-329844-w969lczb 494 5 P p NN cord-329844-w969lczb 494 6 predictive predictive JJ cord-329844-w969lczb 494 7 algorithm algorithm NN cord-329844-w969lczb 494 8 is be VBZ cord-329844-w969lczb 494 9 naïve naïve JJ cord-329844-w969lczb 494 10 and and CC cord-329844-w969lczb 494 11 it -PRON- PRP cord-329844-w969lczb 494 12 is be VBZ cord-329844-w969lczb 494 13 not not RB cord-329844-w969lczb 494 14 expected expect VBN cord-329844-w969lczb 494 15 that that IN cord-329844-w969lczb 494 16 it -PRON- PRP cord-329844-w969lczb 494 17 will will MD cord-329844-w969lczb 494 18 resemble resemble VB cord-329844-w969lczb 494 19 closely closely RB cord-329844-w969lczb 494 20 the the DT cord-329844-w969lczb 494 21 final final JJ cord-329844-w969lczb 494 22 refined refined JJ cord-329844-w969lczb 494 23 form form NN cord-329844-w969lczb 494 24 of of IN cord-329844-w969lczb 494 25 the the DT cord-329844-w969lczb 494 26 algorithm algorithm NN cord-329844-w969lczb 494 27 , , , cord-329844-w969lczb 494 28 which which WDT cord-329844-w969lczb 494 29 will will MD cord-329844-w969lczb 494 30 based base VBN cord-329844-w969lczb 494 31 on on IN cord-329844-w969lczb 494 32 more more RBR cord-329844-w969lczb 494 33 rigorously rigorously RB cord-329844-w969lczb 494 34 on on IN cord-329844-w969lczb 494 35 principles principle NNS cord-329844-w969lczb 494 36 closer close RBR cord-329844-w969lczb 494 37 to to IN cord-329844-w969lczb 494 38 those those DT cord-329844-w969lczb 494 39 of of IN cord-329844-w969lczb 494 40 the the DT cord-329844-w969lczb 494 41 GOR GOR NNP cord-329844-w969lczb 494 42 method method NN cord-329844-w969lczb 494 43 [ [ -LRB- cord-329844-w969lczb 494 44 20 20 CD cord-329844-w969lczb 494 45 ] ] -RRB- cord-329844-w969lczb 494 46 , , . cord-329844-w969lczb 495 1 the the DT cord-329844-w969lczb 495 2 Hyperbolic hyperbolic JJ cord-329844-w969lczb 495 3 Dirac Dirac NNP cord-329844-w969lczb 495 4 Net Net NNP cord-329844-w969lczb 495 5 [ [ -LRB- cord-329844-w969lczb 495 6 21 21 CD cord-329844-w969lczb 495 7 ] ] -RRB- cord-329844-w969lczb 495 8 [ [ -LRB- cord-329844-w969lczb 495 9 22 22 CD cord-329844-w969lczb 495 10 ] ] -RRB- cord-329844-w969lczb 495 11 [ [ -LRB- cord-329844-w969lczb 495 12 23 23 CD cord-329844-w969lczb 495 13 ] ] -RRB- cord-329844-w969lczb 495 14 , , , cord-329844-w969lczb 495 15 the the DT cord-329844-w969lczb 495 16 association association NN cord-329844-w969lczb 495 17 Q Q NNP cord-329844-w969lczb 495 18 - - HYPH cord-329844-w969lczb 495 19 UEL UEL NNP cord-329844-w969lczb 495 20 language language NN cord-329844-w969lczb 495 21 , , , cord-329844-w969lczb 495 22 and and CC cord-329844-w969lczb 495 23 the the DT cord-329844-w969lczb 495 24 BionIngine BionIngine NNP cord-329844-w969lczb 495 25 implementation implementation NN cord-329844-w969lczb 495 26 including include VBG cord-329844-w969lczb 495 27 its -PRON- PRP$ cord-329844-w969lczb 495 28 new new JJ cord-329844-w969lczb 495 29 algorithms algorithm NNS cord-329844-w969lczb 495 30 [ [ -LRB- cord-329844-w969lczb 495 31 25 25 CD cord-329844-w969lczb 495 32 ] ] -RRB- cord-329844-w969lczb 495 33 [ [ -LRB- cord-329844-w969lczb 495 34 26 26 CD cord-329844-w969lczb 495 35 ] ] -RRB- cord-329844-w969lczb 495 36 [ [ -LRB- cord-329844-w969lczb 495 37 27 27 CD cord-329844-w969lczb 495 38 ] ] -RRB- cord-329844-w969lczb 495 39 [ [ -LRB- cord-329844-w969lczb 495 40 28 28 CD cord-329844-w969lczb 495 41 ] ] -RRB- cord-329844-w969lczb 495 42 . . . cord-329844-w969lczb 496 1 The the DT cord-329844-w969lczb 496 2 impression impression NN cord-329844-w969lczb 496 3 of of IN cord-329844-w969lczb 496 4 good good JJ cord-329844-w969lczb 496 5 performance performance NN cord-329844-w969lczb 496 6 for for IN cord-329844-w969lczb 496 7 the the DT cord-329844-w969lczb 496 8 current current JJ cord-329844-w969lczb 496 9 SABR SABR NNP cord-329844-w969lczb 496 10 - - HYPH cord-329844-w969lczb 496 11 P p NN cord-329844-w969lczb 496 12 method method NN cord-329844-w969lczb 496 13 largely largely RB cord-329844-w969lczb 496 14 arises arise VBZ cord-329844-w969lczb 496 15 from from IN cord-329844-w969lczb 496 16 the the DT cord-329844-w969lczb 496 17 fact fact NN cord-329844-w969lczb 496 18 that that IN cord-329844-w969lczb 496 19 it -PRON- PRP cord-329844-w969lczb 496 20 is be VBZ cord-329844-w969lczb 496 21 only only RB cord-329844-w969lczb 496 22 required require VBN cord-329844-w969lczb 496 23 to to TO cord-329844-w969lczb 496 24 predict predict VB cord-329844-w969lczb 496 25 the the DT cord-329844-w969lczb 496 26 sialic sialic JJ cord-329844-w969lczb 496 27 acid acid NN cord-329844-w969lczb 496 28 glycan glycan NN cord-329844-w969lczb 496 29 binding bind VBG cord-329844-w969lczb 496 30 properties property NNS cord-329844-w969lczb 496 31 of of IN cord-329844-w969lczb 496 32 whole whole JJ cord-329844-w969lczb 496 33 domains domain NNS cord-329844-w969lczb 496 34 or or CC cord-329844-w969lczb 496 35 proteins protein NNS cord-329844-w969lczb 496 36 , , , cord-329844-w969lczb 496 37 not not RB cord-329844-w969lczb 496 38 highly highly RB cord-329844-w969lczb 496 39 localized localize VBN cord-329844-w969lczb 496 40 subsequences subsequence NNS cord-329844-w969lczb 496 41 or or CC cord-329844-w969lczb 496 42 surface surface NN cord-329844-w969lczb 496 43 patches patch NNS cord-329844-w969lczb 496 44 . . . cord-329844-w969lczb 497 1 In in IN cord-329844-w969lczb 497 2 essence essence NN cord-329844-w969lczb 497 3 , , , cord-329844-w969lczb 497 4 the the DT cord-329844-w969lczb 497 5 method method NN cord-329844-w969lczb 497 6 is be VBZ cord-329844-w969lczb 497 7 really really RB cord-329844-w969lczb 497 8 doing do VBG cord-329844-w969lczb 497 9 little little JJ cord-329844-w969lczb 497 10 more more JJR cord-329844-w969lczb 497 11 than than IN cord-329844-w969lczb 497 12 capture capture VB cord-329844-w969lczb 497 13 and and CC cord-329844-w969lczb 497 14 quantify quantify VB cord-329844-w969lczb 497 15 in in IN cord-329844-w969lczb 497 16 an an DT cord-329844-w969lczb 497 17 algorithm algorithm NN cord-329844-w969lczb 497 18 the the DT cord-329844-w969lczb 497 19 visual visual JJ cord-329844-w969lczb 497 20 inspection inspection NN cord-329844-w969lczb 497 21 of of IN cord-329844-w969lczb 497 22 sugar sugar NN cord-329844-w969lczb 497 23 binding binding NN cord-329844-w969lczb 497 24 domains domain NNS cord-329844-w969lczb 497 25 and and CC cord-329844-w969lczb 497 26 proteins protein NNS cord-329844-w969lczb 497 27 and and CC cord-329844-w969lczb 497 28 the the DT cord-329844-w969lczb 497 29 observations observation NNS cord-329844-w969lczb 497 30 of of IN cord-329844-w969lczb 497 31 other other JJ cord-329844-w969lczb 497 32 workers worker NNS cord-329844-w969lczb 497 33 as as IN cord-329844-w969lczb 497 34 discussed discuss VBN cord-329844-w969lczb 497 35 above above RB cord-329844-w969lczb 497 36 . . . cord-329844-w969lczb 498 1 However however RB cord-329844-w969lczb 498 2 , , , cord-329844-w969lczb 498 3 the the DT cord-329844-w969lczb 498 4 method method NN cord-329844-w969lczb 498 5 was be VBD cord-329844-w969lczb 498 6 only only RB cord-329844-w969lczb 498 7 required require VBN cord-329844-w969lczb 498 8 to to TO cord-329844-w969lczb 498 9 help help VB cord-329844-w969lczb 498 10 explore explore VB cord-329844-w969lczb 498 11 potential potential JJ cord-329844-w969lczb 498 12 non non JJ cord-329844-w969lczb 498 13 - - JJ cord-329844-w969lczb 498 14 covalent covalent JJ cord-329844-w969lczb 498 15 sialic sialic NN cord-329844-w969lczb 498 16 acid acid NN cord-329844-w969lczb 498 17 glycan glycan NN cord-329844-w969lczb 498 18 binding bind VBG cord-329844-w969lczb 498 19 sites site NNS cord-329844-w969lczb 498 20 in in IN cord-329844-w969lczb 498 21 the the DT cord-329844-w969lczb 498 22 spike spike NN cord-329844-w969lczb 498 23 glycoprotein glycoprotein NN cord-329844-w969lczb 498 24 , , , cord-329844-w969lczb 498 25 and and CC cord-329844-w969lczb 498 26 in in IN cord-329844-w969lczb 498 27 that that DT cord-329844-w969lczb 498 28 regard regard NN cord-329844-w969lczb 498 29 it -PRON- PRP cord-329844-w969lczb 498 30 has have VBZ cord-329844-w969lczb 498 31 proven prove VBN cord-329844-w969lczb 498 32 adequate adequate JJ cord-329844-w969lczb 498 33 and and CC cord-329844-w969lczb 498 34 valuable valuable JJ cord-329844-w969lczb 498 35 for for IN cord-329844-w969lczb 498 36 present present JJ cord-329844-w969lczb 498 37 purposes purpose NNS cord-329844-w969lczb 498 38 . . . cord-329844-w969lczb 499 1 It -PRON- PRP cord-329844-w969lczb 499 2 also also RB cord-329844-w969lczb 499 3 suggests suggest VBZ cord-329844-w969lczb 499 4 a a DT cord-329844-w969lczb 499 5 more more RBR cord-329844-w969lczb 499 6 refined refined JJ cord-329844-w969lczb 499 7 approach approach NN cord-329844-w969lczb 499 8 may may MD cord-329844-w969lczb 499 9 perform perform VB cord-329844-w969lczb 499 10 well well RB cord-329844-w969lczb 499 11 because because IN cord-329844-w969lczb 499 12 false false JJ cord-329844-w969lczb 499 13 positives positive NNS cord-329844-w969lczb 499 14 and and CC cord-329844-w969lczb 499 15 false false JJ cord-329844-w969lczb 499 16 negatives negative NNS cord-329844-w969lczb 499 17 were be VBD cord-329844-w969lczb 499 18 mainly mainly RB cord-329844-w969lczb 499 19 just just RB cord-329844-w969lczb 499 20 over over IN cord-329844-w969lczb 499 21 the the DT cord-329844-w969lczb 499 22 boundary boundary NN cord-329844-w969lczb 499 23 and and CC cord-329844-w969lczb 499 24 just just RB cord-329844-w969lczb 499 25 under under IN cord-329844-w969lczb 499 26 it -PRON- PRP cord-329844-w969lczb 499 27 respectively respectively RB cord-329844-w969lczb 499 28 . . . cord-329844-w969lczb 500 1 The the DT cord-329844-w969lczb 500 2 current current JJ cord-329844-w969lczb 500 3 predictions prediction NNS cord-329844-w969lczb 500 4 also also RB cord-329844-w969lczb 500 5 indicate indicate VBP cord-329844-w969lczb 500 6 a a DT cord-329844-w969lczb 500 7 research research NN cord-329844-w969lczb 500 8 direction direction NN cord-329844-w969lczb 500 9 in in IN cord-329844-w969lczb 500 10 which which WDT cord-329844-w969lczb 500 11 to to TO cord-329844-w969lczb 500 12 explore explore VB cord-329844-w969lczb 500 13 . . . cord-329844-w969lczb 501 1 The the DT cord-329844-w969lczb 501 2 parameters parameter NNS cord-329844-w969lczb 501 3 for for IN cord-329844-w969lczb 501 4 the the DT cord-329844-w969lczb 501 5 general general JJ cord-329844-w969lczb 501 6 sugar sugar NN cord-329844-w969lczb 501 7 binding bind VBG cord-329844-w969lczb 501 8 capacity capacity NN cord-329844-w969lczb 501 9 of of IN cord-329844-w969lczb 501 10 amino amino JJ cord-329844-w969lczb 501 11 acids acid NNS cord-329844-w969lczb 501 12 residues residue NNS cord-329844-w969lczb 501 13 are be VBP cord-329844-w969lczb 501 14 very very RB cord-329844-w969lczb 501 15 different different JJ cord-329844-w969lczb 501 16 to to IN cord-329844-w969lczb 501 17 those those DT cord-329844-w969lczb 501 18 used use VBN cord-329844-w969lczb 501 19 by by IN cord-329844-w969lczb 501 20 other other JJ cord-329844-w969lczb 501 21 workers worker NNS cord-329844-w969lczb 501 22 and and CC cord-329844-w969lczb 501 23 here here RB cord-329844-w969lczb 501 24 the the DT cord-329844-w969lczb 501 25 focus focus NN cord-329844-w969lczb 501 26 has have VBZ cord-329844-w969lczb 501 27 been be VBN cord-329844-w969lczb 501 28 on on IN cord-329844-w969lczb 501 29 sialic sialic JJ cord-329844-w969lczb 501 30 glycans glycan NNS cord-329844-w969lczb 501 31 versus versus IN cord-329844-w969lczb 501 32 other other JJ cord-329844-w969lczb 501 33 saccharide saccharide NN cord-329844-w969lczb 501 34 - - HYPH cord-329844-w969lczb 501 35 based base VBN cord-329844-w969lczb 501 36 molecules molecule NNS cord-329844-w969lczb 501 37 . . . cord-329844-w969lczb 502 1 In in IN cord-329844-w969lczb 502 2 this this DT cord-329844-w969lczb 502 3 , , , cord-329844-w969lczb 502 4 perhaps perhaps RB cord-329844-w969lczb 502 5 the the DT cord-329844-w969lczb 502 6 most most RBS cord-329844-w969lczb 502 7 surprising surprising JJ cord-329844-w969lczb 502 8 finding finding NN cord-329844-w969lczb 502 9 of of IN cord-329844-w969lczb 502 10 all all DT cord-329844-w969lczb 502 11 is be VBZ cord-329844-w969lczb 502 12 the the DT cord-329844-w969lczb 502 13 apparent apparent JJ cord-329844-w969lczb 502 14 ability ability NN cord-329844-w969lczb 502 15 of of IN cord-329844-w969lczb 502 16 the the DT cord-329844-w969lczb 502 17 method method NN cord-329844-w969lczb 502 18 to to TO cord-329844-w969lczb 502 19 distinguish distinguish VB cord-329844-w969lczb 502 20 between between IN cord-329844-w969lczb 502 21 sialic sialic JJ cord-329844-w969lczb 502 22 acid acid NN cord-329844-w969lczb 502 23 containing contain VBG cord-329844-w969lczb 502 24 glycans glycan NNS cord-329844-w969lczb 502 25 and and CC cord-329844-w969lczb 502 26 other other JJ cord-329844-w969lczb 502 27 sugars sugar NNS cord-329844-w969lczb 502 28 in in IN cord-329844-w969lczb 502 29 the the DT cord-329844-w969lczb 502 30 case case NN cord-329844-w969lczb 502 31 of of IN cord-329844-w969lczb 502 32 lectins lectin NNS cord-329844-w969lczb 502 33 . . . cord-329844-w969lczb 503 1 This this DT cord-329844-w969lczb 503 2 is be VBZ cord-329844-w969lczb 503 3 because because IN cord-329844-w969lczb 503 4 non non JJ cord-329844-w969lczb 503 5 - - JJ cord-329844-w969lczb 503 6 sialic sialic JJ cord-329844-w969lczb 503 7 sugars sugar NNS cord-329844-w969lczb 503 8 such such JJ cord-329844-w969lczb 503 9 as as IN cord-329844-w969lczb 503 10 mannose mannose NN cord-329844-w969lczb 503 11 and and CC cord-329844-w969lczb 503 12 fucose fucose NNS cord-329844-w969lczb 503 13 can can MD cord-329844-w969lczb 503 14 occur occur VB cord-329844-w969lczb 503 15 in in RB cord-329844-w969lczb 503 16 in in IN cord-329844-w969lczb 503 17 sialic sialic JJ cord-329844-w969lczb 503 18 acid acid NN cord-329844-w969lczb 503 19 glycans glycan NNS cord-329844-w969lczb 503 20 , , , cord-329844-w969lczb 503 21 and and CC cord-329844-w969lczb 503 22 prediction prediction NN cord-329844-w969lczb 503 23 results result NNS cord-329844-w969lczb 503 24 hint hint VBP cord-329844-w969lczb 503 25 that that IN cord-329844-w969lczb 503 26 there there EX cord-329844-w969lczb 503 27 is be VBZ cord-329844-w969lczb 503 28 likely likely JJ cord-329844-w969lczb 503 29 to to TO cord-329844-w969lczb 503 30 be be VB cord-329844-w969lczb 503 31 some some DT cord-329844-w969lczb 503 32 distinguishing distinguishing JJ cord-329844-w969lczb 503 33 feature feature NN cord-329844-w969lczb 503 34 for for IN cord-329844-w969lczb 503 35 a a DT cord-329844-w969lczb 503 36 majority majority NN cord-329844-w969lczb 503 37 of of IN cord-329844-w969lczb 503 38 cases case NNS cord-329844-w969lczb 503 39 that that WDT cord-329844-w969lczb 503 40 makes make VBZ cord-329844-w969lczb 503 41 a a DT cord-329844-w969lczb 503 42 specific specific JJ cord-329844-w969lczb 503 43 recognition recognition NN cord-329844-w969lczb 503 44 . . . cord-329844-w969lczb 504 1 In in IN cord-329844-w969lczb 504 2 this this DT cord-329844-w969lczb 504 3 respect respect NN cord-329844-w969lczb 504 4 it -PRON- PRP cord-329844-w969lczb 504 5 would would MD cord-329844-w969lczb 504 6 seem seem VB cord-329844-w969lczb 504 7 initially initially RB cord-329844-w969lczb 504 8 of of IN cord-329844-w969lczb 504 9 concern concern NN cord-329844-w969lczb 504 10 for for IN cord-329844-w969lczb 504 11 the the DT cord-329844-w969lczb 504 12 sensibleness sensibleness NN cord-329844-w969lczb 504 13 of of IN cord-329844-w969lczb 504 14 the the DT cord-329844-w969lczb 504 15 predictions prediction NNS cord-329844-w969lczb 504 16 that that WDT cord-329844-w969lczb 504 17 , , , cord-329844-w969lczb 504 18 for for IN cord-329844-w969lczb 504 19 example example NN cord-329844-w969lczb 504 20 , , , cord-329844-w969lczb 504 21 mannose mannose NN cord-329844-w969lczb 504 22 - - HYPH cord-329844-w969lczb 504 23 binding bind VBG cord-329844-w969lczb 504 24 lectin lectin NN cord-329844-w969lczb 504 25 binds bind VBZ cord-329844-w969lczb 504 26 to to IN cord-329844-w969lczb 504 27 a a DT cord-329844-w969lczb 504 28 range range NN cord-329844-w969lczb 504 29 of of IN cord-329844-w969lczb 504 30 sugars sugar NNS cord-329844-w969lczb 504 31 that that WDT cord-329844-w969lczb 504 32 also also RB cord-329844-w969lczb 504 33 include include VBP cord-329844-w969lczb 504 34 N n NN cord-329844-w969lczb 504 35 - - HYPH cord-329844-w969lczb 504 36 acetyl acetyl NN cord-329844-w969lczb 504 37 - - HYPH cord-329844-w969lczb 504 38 D d NN cord-329844-w969lczb 504 39 - - HYPH cord-329844-w969lczb 504 40 glucosamine glucosamine NN cord-329844-w969lczb 504 41 , , , cord-329844-w969lczb 504 42 N N NNP cord-329844-w969lczb 504 43 - - HYPH cord-329844-w969lczb 504 44 acetyl acetyl NNP cord-329844-w969lczb 504 45 - - HYPH cord-329844-w969lczb 504 46 mannosamine mannosamine NNP cord-329844-w969lczb 504 47 , , , cord-329844-w969lczb 504 48 fucose fucose NNP cord-329844-w969lczb 504 49 and and CC cord-329844-w969lczb 504 50 glucose glucose NN cord-329844-w969lczb 504 51 . . . cord-329844-w969lczb 505 1 It -PRON- PRP cord-329844-w969lczb 505 2 is be VBZ cord-329844-w969lczb 505 3 therefore therefore RB cord-329844-w969lczb 505 4 possible possible JJ cord-329844-w969lczb 505 5 that that DT cord-329844-w969lczb 505 6 research research NN cord-329844-w969lczb 505 7 in in IN cord-329844-w969lczb 505 8 this this DT cord-329844-w969lczb 505 9 direction direction NN cord-329844-w969lczb 505 10 will will MD cord-329844-w969lczb 505 11 not not RB cord-329844-w969lczb 505 12 be be VB cord-329844-w969lczb 505 13 so so RB cord-329844-w969lczb 505 14 profitable profitable JJ cord-329844-w969lczb 505 15 because because IN cord-329844-w969lczb 505 16 the the DT cord-329844-w969lczb 505 17 above above JJ cord-329844-w969lczb 505 18 distinguishing distinguishing JJ cord-329844-w969lczb 505 19 behavior behavior NN cord-329844-w969lczb 505 20 of of IN cord-329844-w969lczb 505 21 the the DT cord-329844-w969lczb 505 22 algorithm algorithm NN cord-329844-w969lczb 505 23 might may MD cord-329844-w969lczb 505 24 be be VB cord-329844-w969lczb 505 25 to to IN cord-329844-w969lczb 505 26 some some DT cord-329844-w969lczb 505 27 extent extent NN cord-329844-w969lczb 505 28 coincidental coincidental JJ cord-329844-w969lczb 505 29 . . . cord-329844-w969lczb 506 1 Be be VB cord-329844-w969lczb 506 2 that that DT cord-329844-w969lczb 506 3 as as IN cord-329844-w969lczb 506 4 it -PRON- PRP cord-329844-w969lczb 506 5 may may MD cord-329844-w969lczb 506 6 , , , cord-329844-w969lczb 506 7 the the DT cord-329844-w969lczb 506 8 predictions prediction NNS cord-329844-w969lczb 506 9 are be VBP cord-329844-w969lczb 506 10 remarkably remarkably RB cord-329844-w969lczb 506 11 much much RB cord-329844-w969lczb 506 12 better well JJR cord-329844-w969lczb 506 13 than than IN cord-329844-w969lczb 506 14 expected expect VBN cord-329844-w969lczb 506 15 , , , cord-329844-w969lczb 506 16 and and CC cord-329844-w969lczb 506 17 should should MD cord-329844-w969lczb 506 18 certainly certainly RB cord-329844-w969lczb 506 19 be be VB cord-329844-w969lczb 506 20 challenged challenge VBN cord-329844-w969lczb 506 21 by by IN cord-329844-w969lczb 506 22 researchers researcher NNS cord-329844-w969lczb 506 23 in in IN cord-329844-w969lczb 506 24 order order NN cord-329844-w969lczb 506 25 to to TO cord-329844-w969lczb 506 26 improve improve VB cord-329844-w969lczb 506 27 such such JJ cord-329844-w969lczb 506 28 methods method NNS cord-329844-w969lczb 506 29 . . . cord-329844-w969lczb 507 1 Specifically specifically RB cord-329844-w969lczb 507 2 , , , cord-329844-w969lczb 507 3 a a DT cord-329844-w969lczb 507 4 larger large JJR cord-329844-w969lczb 507 5 sample sample NN cord-329844-w969lczb 507 6 may may MD cord-329844-w969lczb 507 7 require require VB cord-329844-w969lczb 507 8 a a DT cord-329844-w969lczb 507 9 threshold threshold NN cord-329844-w969lczb 507 10 adjustment adjustment NN cord-329844-w969lczb 507 11 or or CC cord-329844-w969lczb 507 12 corresponding corresponding JJ cord-329844-w969lczb 507 13 rescaling rescaling NN cord-329844-w969lczb 507 14 , , , cord-329844-w969lczb 507 15 perhaps perhaps RB cord-329844-w969lczb 507 16 resulting result VBG cord-329844-w969lczb 507 17 in in IN cord-329844-w969lczb 507 18 a a DT cord-329844-w969lczb 507 19 deterioration deterioration NN cord-329844-w969lczb 507 20 of of IN cord-329844-w969lczb 507 21 performance performance NN cord-329844-w969lczb 507 22 particularly particularly RB cord-329844-w969lczb 507 23 in in IN cord-329844-w969lczb 507 24 regard regard NN cord-329844-w969lczb 507 25 to to IN cord-329844-w969lczb 507 26 distinguishing distinguish VBG cord-329844-w969lczb 507 27 lectins lectin NNS cord-329844-w969lczb 507 28 . . . cord-329844-w969lczb 508 1 Nonetheless nonetheless RB cord-329844-w969lczb 508 2 , , , cord-329844-w969lczb 508 3 it -PRON- PRP cord-329844-w969lczb 508 4 is be VBZ cord-329844-w969lczb 508 5 noteworthy noteworthy JJ cord-329844-w969lczb 508 6 that that IN cord-329844-w969lczb 508 7 ultimately ultimately RB cord-329844-w969lczb 508 8 human human JJ cord-329844-w969lczb 508 9 glycan glycan NN cord-329844-w969lczb 508 10 binding bind VBG cord-329844-w969lczb 508 11 proteins protein NNS cord-329844-w969lczb 508 12 have have VBP cord-329844-w969lczb 508 13 to to TO cord-329844-w969lczb 508 14 overcome overcome VB cord-329844-w969lczb 508 15 the the DT cord-329844-w969lczb 508 16 same same JJ cord-329844-w969lczb 508 17 problem problem NN cord-329844-w969lczb 508 18 as as IN cord-329844-w969lczb 508 19 the the DT cord-329844-w969lczb 508 20 above above JJ cord-329844-w969lczb 508 21 kind kind NN cord-329844-w969lczb 508 22 of of IN cord-329844-w969lczb 508 23 prediction prediction NN cord-329844-w969lczb 508 24 algorithm algorithm NN cord-329844-w969lczb 508 25 . . . cord-329844-w969lczb 509 1 While while IN cord-329844-w969lczb 509 2 this this DT cord-329844-w969lczb 509 3 broad broad JJ cord-329844-w969lczb 509 4 range range NN cord-329844-w969lczb 509 5 of of IN cord-329844-w969lczb 509 6 sugar sugar NN cord-329844-w969lczb 509 7 recognition recognition NN cord-329844-w969lczb 509 8 by by IN cord-329844-w969lczb 509 9 the the DT cord-329844-w969lczb 509 10 mannose mannose NN cord-329844-w969lczb 509 11 - - HYPH cord-329844-w969lczb 509 12 binding bind VBG cord-329844-w969lczb 509 13 lection lection NN cord-329844-w969lczb 509 14 permits permit VBZ cord-329844-w969lczb 509 15 that that DT cord-329844-w969lczb 509 16 lectin lectin NN cord-329844-w969lczb 509 17 to to TO cord-329844-w969lczb 509 18 interact interact VB cord-329844-w969lczb 509 19 with with IN cord-329844-w969lczb 509 20 a a DT cord-329844-w969lczb 509 21 wide wide JJ cord-329844-w969lczb 509 22 selection selection NN cord-329844-w969lczb 509 23 of of IN cord-329844-w969lczb 509 24 pathogens pathogen NNS cord-329844-w969lczb 509 25 ( ( -LRB- cord-329844-w969lczb 509 26 viruses virus NNS cord-329844-w969lczb 509 27 , , , cord-329844-w969lczb 509 28 bacteria bacteria NNS cord-329844-w969lczb 509 29 , , , cord-329844-w969lczb 509 30 yeasts yeast NNS cord-329844-w969lczb 509 31 , , , cord-329844-w969lczb 509 32 fungi fungus NNS cord-329844-w969lczb 509 33 and and CC cord-329844-w969lczb 509 34 protozoa protozoan NNS cord-329844-w969lczb 509 35 ) ) -RRB- cord-329844-w969lczb 509 36 decorated decorate VBN cord-329844-w969lczb 509 37 with with IN cord-329844-w969lczb 509 38 such such JJ cord-329844-w969lczb 509 39 sugars sugar NNS cord-329844-w969lczb 509 40 , , , cord-329844-w969lczb 509 41 there there EX cord-329844-w969lczb 509 42 must must MD cord-329844-w969lczb 509 43 be be VB cord-329844-w969lczb 509 44 some some DT cord-329844-w969lczb 509 45 kind kind NN cord-329844-w969lczb 509 46 of of IN cord-329844-w969lczb 509 47 distinguishing distinguishing JJ cord-329844-w969lczb 509 48 aspect aspect NN cord-329844-w969lczb 509 49 such such JJ cord-329844-w969lczb 509 50 that that WDT cord-329844-w969lczb 509 51 is be VBZ cord-329844-w969lczb 509 52 not not RB cord-329844-w969lczb 509 53 decoyed decoy VBN cord-329844-w969lczb 509 54 by by IN cord-329844-w969lczb 509 55 the the DT cord-329844-w969lczb 509 56 sialic sialic JJ cord-329844-w969lczb 509 57 acid acid NN cord-329844-w969lczb 509 58 glycans glycan NNS cord-329844-w969lczb 509 59 of of IN cord-329844-w969lczb 509 60 the the DT cord-329844-w969lczb 509 61 human human JJ cord-329844-w969lczb 509 62 host host NN cord-329844-w969lczb 509 63 . . . cord-329844-w969lczb 510 1 A a DT cord-329844-w969lczb 510 2 more more RBR cord-329844-w969lczb 510 3 mundane mundane JJ cord-329844-w969lczb 510 4 problem problem NN cord-329844-w969lczb 510 5 in in IN cord-329844-w969lczb 510 6 extending extend VBG cord-329844-w969lczb 510 7 the the DT cord-329844-w969lczb 510 8 study study NN cord-329844-w969lczb 510 9 is be VBZ cord-329844-w969lczb 510 10 that that IN cord-329844-w969lczb 510 11 the the DT cord-329844-w969lczb 510 12 correct correct JJ cord-329844-w969lczb 510 13 state state NN cord-329844-w969lczb 510 14 as as IN cord-329844-w969lczb 510 15 sialic sialic JJ cord-329844-w969lczb 510 16 acid acid NN cord-329844-w969lczb 510 17 glycan glycan NN cord-329844-w969lczb 510 18 binding binding NN cord-329844-w969lczb 510 19 , , , cord-329844-w969lczb 510 20 other other JJ cord-329844-w969lczb 510 21 sugar sugar NN cord-329844-w969lczb 510 22 binding binding NN cord-329844-w969lczb 510 23 , , , cord-329844-w969lczb 510 24 or or CC cord-329844-w969lczb 510 25 not not RB cord-329844-w969lczb 510 26 binding bind VBG cord-329844-w969lczb 510 27 any any DT cord-329844-w969lczb 510 28 kind kind NN cord-329844-w969lczb 510 29 of of IN cord-329844-w969lczb 510 30 sugar sugar NN cord-329844-w969lczb 510 31 , , , cord-329844-w969lczb 510 32 may may MD cord-329844-w969lczb 510 33 be be VB cord-329844-w969lczb 510 34 uncertain uncertain JJ cord-329844-w969lczb 510 35 or or CC cord-329844-w969lczb 510 36 a a DT cord-329844-w969lczb 510 37 matter matter NN cord-329844-w969lczb 510 38 of of IN cord-329844-w969lczb 510 39 degree degree NN cord-329844-w969lczb 510 40 . . . cord-329844-w969lczb 511 1 Further further JJ cord-329844-w969lczb 511 2 studies study NNS cord-329844-w969lczb 511 3 at at IN cord-329844-w969lczb 511 4 time time NN cord-329844-w969lczb 511 5 of of IN cord-329844-w969lczb 511 6 writing writing NN cord-329844-w969lczb 511 7 suggested suggest VBD cord-329844-w969lczb 511 8 only only RB cord-329844-w969lczb 511 9 about about RB cord-329844-w969lczb 511 10 70 70 CD cord-329844-w969lczb 511 11 % % NN cord-329844-w969lczb 511 12 for for IN cord-329844-w969lczb 511 13 each each DT cord-329844-w969lczb 511 14 of of IN cord-329844-w969lczb 511 15 accuracy accuracy NN cord-329844-w969lczb 511 16 , , , cord-329844-w969lczb 511 17 sensitivity sensitivity NN cord-329844-w969lczb 511 18 , , , cord-329844-w969lczb 511 19 and and CC cord-329844-w969lczb 511 20 specificity specificity NN cord-329844-w969lczb 511 21 , , , cord-329844-w969lczb 511 22 but but CC cord-329844-w969lczb 511 23 this this DT cord-329844-w969lczb 511 24 larger large JJR cord-329844-w969lczb 511 25 set set NN cord-329844-w969lczb 511 26 is be VBZ cord-329844-w969lczb 511 27 , , , cord-329844-w969lczb 511 28 as as RB cord-329844-w969lczb 511 29 yet yet RB cord-329844-w969lczb 511 30 , , , cord-329844-w969lczb 511 31 of of IN cord-329844-w969lczb 511 32 dubious dubious JJ cord-329844-w969lczb 511 33 quality quality NN cord-329844-w969lczb 511 34 for for IN cord-329844-w969lczb 511 35 the the DT cord-329844-w969lczb 511 36 purpose purpose NN cord-329844-w969lczb 511 37 . . . cord-329844-w969lczb 512 1 Some some DT cord-329844-w969lczb 512 2 proteins protein NNS cord-329844-w969lczb 512 3 were be VBD cord-329844-w969lczb 512 4 believed believe VBN cord-329844-w969lczb 512 5 , , , cord-329844-w969lczb 512 6 rather rather RB cord-329844-w969lczb 512 7 than than IN cord-329844-w969lczb 512 8 known know VBN cord-329844-w969lczb 512 9 , , , cord-329844-w969lczb 512 10 to to TO cord-329844-w969lczb 512 11 bind bind VB cord-329844-w969lczb 512 12 sialic sialic JJ cord-329844-w969lczb 512 13 acid acid NN cord-329844-w969lczb 512 14 glycans glycan NNS cord-329844-w969lczb 512 15 , , , cord-329844-w969lczb 512 16 binding binding NN cord-329844-w969lczb 512 17 might may MD cord-329844-w969lczb 512 18 be be VB cord-329844-w969lczb 512 19 weak weak JJ cord-329844-w969lczb 512 20 or or CC cord-329844-w969lczb 512 21 less less RBR cord-329844-w969lczb 512 22 specific specific JJ cord-329844-w969lczb 512 23 or or CC cord-329844-w969lczb 512 24 of of IN cord-329844-w969lczb 512 25 multiple multiple JJ cord-329844-w969lczb 512 26 types type NNS cord-329844-w969lczb 512 27 , , , cord-329844-w969lczb 512 28 or or CC cord-329844-w969lczb 512 29 the the DT cord-329844-w969lczb 512 30 domain domain NN cord-329844-w969lczb 512 31 or or CC cord-329844-w969lczb 512 32 approximate approximate JJ cord-329844-w969lczb 512 33 location location NN cord-329844-w969lczb 512 34 of of IN cord-329844-w969lczb 512 35 the the DT cord-329844-w969lczb 512 36 binding binding NN cord-329844-w969lczb 512 37 site site NN cord-329844-w969lczb 512 38 can can MD cord-329844-w969lczb 512 39 be be VB cord-329844-w969lczb 512 40 unclear unclear JJ cord-329844-w969lczb 512 41 . . . cord-329844-w969lczb 513 1 Related relate VBN cord-329844-w969lczb 513 2 to to IN cord-329844-w969lczb 513 3 that that DT cord-329844-w969lczb 513 4 is be VBZ cord-329844-w969lczb 513 5 a a DT cord-329844-w969lczb 513 6 difficulty difficulty NN cord-329844-w969lczb 513 7 that that WDT cord-329844-w969lczb 513 8 the the DT cord-329844-w969lczb 513 9 performance performance NN cord-329844-w969lczb 513 10 of of IN cord-329844-w969lczb 513 11 any any DT cord-329844-w969lczb 513 12 prediction prediction NN cord-329844-w969lczb 513 13 method method NN cord-329844-w969lczb 513 14 of of IN cord-329844-w969lczb 513 15 this this DT cord-329844-w969lczb 513 16 kind kind NN cord-329844-w969lczb 513 17 is be VBZ cord-329844-w969lczb 513 18 defensible defensible JJ cord-329844-w969lczb 513 19 , , , cord-329844-w969lczb 513 20 and and CC cord-329844-w969lczb 513 21 possibly possibly RB cord-329844-w969lczb 513 22 unfairly unfairly RB cord-329844-w969lczb 513 23 defensible defensible JJ cord-329844-w969lczb 513 24 , , , cord-329844-w969lczb 513 25 in in IN cord-329844-w969lczb 513 26 regard regard NN cord-329844-w969lczb 513 27 to to IN cord-329844-w969lczb 513 28 false false JJ cord-329844-w969lczb 513 29 positives positive NNS cord-329844-w969lczb 513 30 : : : cord-329844-w969lczb 513 31 it -PRON- PRP cord-329844-w969lczb 513 32 may may MD cord-329844-w969lczb 513 33 be be VB cord-329844-w969lczb 513 34 that that DT cord-329844-w969lczb 513 35 experiment experiment NN cord-329844-w969lczb 513 36 shows show VBZ cord-329844-w969lczb 513 37 that that IN cord-329844-w969lczb 513 38 a a DT cord-329844-w969lczb 513 39 particular particular JJ cord-329844-w969lczb 513 40 virus virus NN cord-329844-w969lczb 513 41 predicted predict VBD cord-329844-w969lczb 513 42 to to TO cord-329844-w969lczb 513 43 bind bind VB cord-329844-w969lczb 513 44 sialic sialic JJ cord-329844-w969lczb 513 45 acid acid NN cord-329844-w969lczb 513 46 glycans glycan NNS cord-329844-w969lczb 513 47 does do VBZ cord-329844-w969lczb 513 48 not not RB cord-329844-w969lczb 513 49 specifically specifically RB cord-329844-w969lczb 513 50 do do VB cord-329844-w969lczb 513 51 so so RB cord-329844-w969lczb 513 52 , , , cord-329844-w969lczb 513 53 but but CC cord-329844-w969lczb 513 54 perhaps perhaps RB cord-329844-w969lczb 513 55 it -PRON- PRP cord-329844-w969lczb 513 56 once once RB cord-329844-w969lczb 513 57 did do VBD cord-329844-w969lczb 513 58 , , , cord-329844-w969lczb 513 59 in in IN cord-329844-w969lczb 513 60 evolutionary evolutionary JJ cord-329844-w969lczb 513 61 terms term NNS cord-329844-w969lczb 513 62 . . . cord-329844-w969lczb 514 1 This this DT cord-329844-w969lczb 514 2 is be VBZ cord-329844-w969lczb 514 3 particularly particularly RB cord-329844-w969lczb 514 4 relevant relevant JJ cord-329844-w969lczb 514 5 in in IN cord-329844-w969lczb 514 6 regard regard NN cord-329844-w969lczb 514 7 to to IN cord-329844-w969lczb 514 8 studying study VBG cord-329844-w969lczb 514 9 coronaviruses coronaviruse NNS cord-329844-w969lczb 514 10 because because IN cord-329844-w969lczb 514 11 , , , cord-329844-w969lczb 514 12 as as IN cord-329844-w969lczb 514 13 discussed discuss VBN cord-329844-w969lczb 514 14 above above RB cord-329844-w969lczb 514 15 , , , cord-329844-w969lczb 514 16 many many JJ cord-329844-w969lczb 514 17 coronaviruses coronaviruse NNS cord-329844-w969lczb 514 18 certainly certainly RB cord-329844-w969lczb 514 19 do do VBP cord-329844-w969lczb 514 20 bind bind VB cord-329844-w969lczb 514 21 sialic sialic JJ cord-329844-w969lczb 514 22 acid acid NN cord-329844-w969lczb 514 23 glycans glycan NNS cord-329844-w969lczb 514 24 . . . cord-329844-w969lczb 515 1 Of of RB cord-329844-w969lczb 515 2 course course RB cord-329844-w969lczb 515 3 , , , cord-329844-w969lczb 515 4 the the DT cord-329844-w969lczb 515 5 prediction prediction NN cord-329844-w969lczb 515 6 method method NN cord-329844-w969lczb 515 7 would would MD cord-329844-w969lczb 515 8 then then RB cord-329844-w969lczb 515 9 still still RB cord-329844-w969lczb 515 10 be be VB cord-329844-w969lczb 515 11 subject subject JJ cord-329844-w969lczb 515 12 to to IN cord-329844-w969lczb 515 13 the the DT cord-329844-w969lczb 515 14 criticism criticism NN cord-329844-w969lczb 515 15 that that IN cord-329844-w969lczb 515 16 it -PRON- PRP cord-329844-w969lczb 515 17 insufficiently insufficiently RB cord-329844-w969lczb 515 18 sophisticated sophisticated JJ cord-329844-w969lczb 515 19 to to TO cord-329844-w969lczb 515 20 manage manage VB cord-329844-w969lczb 515 21 the the DT cord-329844-w969lczb 515 22 impact impact NN cord-329844-w969lczb 515 23 of of IN cord-329844-w969lczb 515 24 small small JJ cord-329844-w969lczb 515 25 changes change NNS cord-329844-w969lczb 515 26 . . . cord-329844-w969lczb 516 1 For for IN cord-329844-w969lczb 516 2 purely purely RB cord-329844-w969lczb 516 3 theoretical theoretical JJ cord-329844-w969lczb 516 4 methods method NNS cord-329844-w969lczb 516 5 , , , cord-329844-w969lczb 516 6 that that WDT cord-329844-w969lczb 516 7 may may MD cord-329844-w969lczb 516 8 be be VB cord-329844-w969lczb 516 9 an an DT cord-329844-w969lczb 516 10 issue issue NN cord-329844-w969lczb 516 11 for for IN cord-329844-w969lczb 516 12 some some DT cord-329844-w969lczb 516 13 time time NN cord-329844-w969lczb 516 14 : : : cord-329844-w969lczb 516 15 in in IN cord-329844-w969lczb 516 16 the the DT cord-329844-w969lczb 516 17 present present JJ cord-329844-w969lczb 516 18 author author NN cord-329844-w969lczb 516 19 's 's POS cord-329844-w969lczb 516 20 experience experience NN cord-329844-w969lczb 516 21 even even RB cord-329844-w969lczb 516 22 simulations simulation NNS cord-329844-w969lczb 516 23 of of IN cord-329844-w969lczb 516 24 binding bind VBG cord-329844-w969lczb 516 25 of of IN cord-329844-w969lczb 516 26 sugars sugar NNS cord-329844-w969lczb 516 27 to to IN cord-329844-w969lczb 516 28 proteins protein NNS cord-329844-w969lczb 516 29 in in IN cord-329844-w969lczb 516 30 atomic atomic JJ cord-329844-w969lczb 516 31 detail detail NN cord-329844-w969lczb 516 32 tend tend VBP cord-329844-w969lczb 516 33 to to TO cord-329844-w969lczb 516 34 be be VB cord-329844-w969lczb 516 35 difficult difficult JJ cord-329844-w969lczb 516 36 in in IN cord-329844-w969lczb 516 37 view view NN cord-329844-w969lczb 516 38 of of IN cord-329844-w969lczb 516 39 the the DT cord-329844-w969lczb 516 40 complex complex JJ cord-329844-w969lczb 516 41 role role NN cord-329844-w969lczb 516 42 of of IN cord-329844-w969lczb 516 43 water water NN cord-329844-w969lczb 516 44 molecules molecule NNS cord-329844-w969lczb 516 45 . . . cord-329844-w969lczb 517 1 For for IN cord-329844-w969lczb 517 2 example example NN cord-329844-w969lczb 517 3 , , , cord-329844-w969lczb 517 4 water water NN cord-329844-w969lczb 517 5 molecules molecule NNS cord-329844-w969lczb 517 6 commonly commonly RB cord-329844-w969lczb 517 7 represent represent VBP cord-329844-w969lczb 517 8 protein protein NN cord-329844-w969lczb 517 9 - - HYPH cord-329844-w969lczb 517 10 to to IN cord-329844-w969lczb 517 11 - - HYPH cord-329844-w969lczb 517 12 sugar sugar NN cord-329844-w969lczb 517 13 bridges bridge NNS cord-329844-w969lczb 517 14 as as IN cord-329844-w969lczb 517 15 discussed discuss VBN cord-329844-w969lczb 517 16 in in IN cord-329844-w969lczb 517 17 this this DT cord-329844-w969lczb 517 18 paper paper NN cord-329844-w969lczb 517 19 . . . cord-329844-w969lczb 518 1 Potential potential JJ cord-329844-w969lczb 518 2 biological biological JJ cord-329844-w969lczb 518 3 implications implication NNS cord-329844-w969lczb 518 4 arguably arguably RB cord-329844-w969lczb 518 5 support support VBP cord-329844-w969lczb 518 6 the the DT cord-329844-w969lczb 518 7 above above JJ cord-329844-w969lczb 518 8 prediction prediction NN cord-329844-w969lczb 518 9 for for IN cord-329844-w969lczb 518 10 SARS SARS NNP cord-329844-w969lczb 518 11 - - HYPH cord-329844-w969lczb 518 12 CoV-2 CoV-2 NNP cord-329844-w969lczb 518 13 spike spike NN cord-329844-w969lczb 518 14 protein protein NN cord-329844-w969lczb 518 15 . . . cord-329844-w969lczb 519 1 That that RB cord-329844-w969lczb 519 2 is is RB cord-329844-w969lczb 519 3 , , , cord-329844-w969lczb 519 4 the the DT cord-329844-w969lczb 519 5 story story NN cord-329844-w969lczb 519 6 " " `` cord-329844-w969lczb 519 7 makes make VBZ cord-329844-w969lczb 519 8 sense sense NN cord-329844-w969lczb 519 9 " " '' cord-329844-w969lczb 519 10 . . . cord-329844-w969lczb 520 1 Although although IN cord-329844-w969lczb 520 2 the the DT cord-329844-w969lczb 520 3 involvement involvement NN cord-329844-w969lczb 520 4 of of IN cord-329844-w969lczb 520 5 SARS SARS NNP cord-329844-w969lczb 520 6 - - HYPH cord-329844-w969lczb 520 7 CoV CoV NNP cord-329844-w969lczb 520 8 and and CC cord-329844-w969lczb 520 9 SARS SARS NNP cord-329844-w969lczb 520 10 - - HYPH cord-329844-w969lczb 520 11 CoV-2 CoV-2 NNP cord-329844-w969lczb 520 12 with with IN cord-329844-w969lczb 520 13 sialic sialic JJ cord-329844-w969lczb 520 14 acid acid NN cord-329844-w969lczb 520 15 glycans glycan NNS cord-329844-w969lczb 520 16 has have VBZ cord-329844-w969lczb 520 17 been be VBN cord-329844-w969lczb 520 18 rather rather RB cord-329844-w969lczb 520 19 neglected neglect VBN cord-329844-w969lczb 520 20 in in IN cord-329844-w969lczb 520 21 the the DT cord-329844-w969lczb 520 22 literature literature NN cord-329844-w969lczb 520 23 ( ( -LRB- cord-329844-w969lczb 520 24 but but CC cord-329844-w969lczb 520 25 see see VB cord-329844-w969lczb 520 26 below below RB cord-329844-w969lczb 520 27 ) ) -RRB- cord-329844-w969lczb 520 28 , , , cord-329844-w969lczb 520 29 such such JJ cord-329844-w969lczb 520 30 involvement involvement NN cord-329844-w969lczb 520 31 represents represent VBZ cord-329844-w969lczb 520 32 a a DT cord-329844-w969lczb 520 33 prominent prominent JJ cord-329844-w969lczb 520 34 and and CC cord-329844-w969lczb 520 35 well well RB cord-329844-w969lczb 520 36 known know VBN cord-329844-w969lczb 520 37 feature feature NN cord-329844-w969lczb 520 38 in in IN cord-329844-w969lczb 520 39 the the DT cord-329844-w969lczb 520 40 life life NN cord-329844-w969lczb 520 41 history history NN cord-329844-w969lczb 520 42 of of IN cord-329844-w969lczb 520 43 influenza influenza NN cord-329844-w969lczb 520 44 and and CC cord-329844-w969lczb 520 45 other other JJ cord-329844-w969lczb 520 46 viruses virus NNS cord-329844-w969lczb 520 47 , , , cord-329844-w969lczb 520 48 and and CC cord-329844-w969lczb 520 49 appears appear VBZ cord-329844-w969lczb 520 50 no no DT cord-329844-w969lczb 520 51 less less RBR cord-329844-w969lczb 520 52 important important JJ cord-329844-w969lczb 520 53 in in IN cord-329844-w969lczb 520 54 the the DT cord-329844-w969lczb 520 55 life life NN cord-329844-w969lczb 520 56 of of IN cord-329844-w969lczb 520 57 many many JJ cord-329844-w969lczb 520 58 other other JJ cord-329844-w969lczb 520 59 coronaviruses coronaviruse NNS cord-329844-w969lczb 520 60 . . . cord-329844-w969lczb 521 1 Admittedly admittedly RB cord-329844-w969lczb 521 2 , , , cord-329844-w969lczb 521 3 HIV HIV NNP cord-329844-w969lczb 521 4 and and CC cord-329844-w969lczb 521 5 many many JJ cord-329844-w969lczb 521 6 other other JJ cord-329844-w969lczb 521 7 enveloped envelop VBN cord-329844-w969lczb 521 8 viruses virus NNS cord-329844-w969lczb 521 9 do do VBP cord-329844-w969lczb 521 10 not not RB cord-329844-w969lczb 521 11 encode encode VB cord-329844-w969lczb 521 12 hemagglutinin hemagglutinin NN cord-329844-w969lczb 521 13 for for IN cord-329844-w969lczb 521 14 sialic sialic JJ cord-329844-w969lczb 521 15 acid acid NN cord-329844-w969lczb 521 16 binding binding NN cord-329844-w969lczb 521 17 . . . cord-329844-w969lczb 522 1 Instead instead RB cord-329844-w969lczb 522 2 , , , cord-329844-w969lczb 522 3 they -PRON- PRP cord-329844-w969lczb 522 4 interact interact VBP cord-329844-w969lczb 522 5 using use VBG cord-329844-w969lczb 522 6 N n CD cord-329844-w969lczb 522 7 - - HYPH cord-329844-w969lczb 522 8 terminal terminal JJ cord-329844-w969lczb 522 9 sialic sialic NN cord-329844-w969lczb 522 10 acid acid NN cord-329844-w969lczb 522 11 bound bind VBN cord-329844-w969lczb 522 12 to to IN cord-329844-w969lczb 522 13 envelope envelope NN cord-329844-w969lczb 522 14 - - HYPH cord-329844-w969lczb 522 15 associated associate VBN cord-329844-w969lczb 522 16 proteins protein NNS cord-329844-w969lczb 522 17 , , , cord-329844-w969lczb 522 18 like like IN cord-329844-w969lczb 522 19 gp120 gp120 NNP cord-329844-w969lczb 522 20 on on IN cord-329844-w969lczb 522 21 HIV-1 HIV-1 NNP cord-329844-w969lczb 522 22 . . . cord-329844-w969lczb 523 1 However however RB cord-329844-w969lczb 523 2 , , , cord-329844-w969lczb 523 3 the the DT cord-329844-w969lczb 523 4 mode mode NN cord-329844-w969lczb 523 5 of of IN cord-329844-w969lczb 523 6 infection infection NN cord-329844-w969lczb 523 7 is be VBZ cord-329844-w969lczb 523 8 different different JJ cord-329844-w969lczb 523 9 . . . cord-329844-w969lczb 524 1 The the DT cord-329844-w969lczb 524 2 SARS SARS NNP cord-329844-w969lczb 524 3 - - HYPH cord-329844-w969lczb 524 4 CoV-2 CoV-2 NNP cord-329844-w969lczb 524 5 coronavirus coronavirus NN cord-329844-w969lczb 524 6 can can MD cord-329844-w969lczb 524 7 not not RB cord-329844-w969lczb 524 8 jump jump VB cord-329844-w969lczb 524 9 in in IN cord-329844-w969lczb 524 10 a a DT cord-329844-w969lczb 524 11 magical magical JJ cord-329844-w969lczb 524 12 way way NN cord-329844-w969lczb 524 13 from from IN cord-329844-w969lczb 524 14 contaminated contaminated JJ cord-329844-w969lczb 524 15 surfaces surface NNS cord-329844-w969lczb 524 16 to to IN cord-329844-w969lczb 524 17 the the DT cord-329844-w969lczb 524 18 lung lung NN cord-329844-w969lczb 524 19 , , , cord-329844-w969lczb 524 20 and and CC cord-329844-w969lczb 524 21 it -PRON- PRP cord-329844-w969lczb 524 22 is be VBZ cord-329844-w969lczb 524 23 doubtful doubtful JJ cord-329844-w969lczb 524 24 that that IN cord-329844-w969lczb 524 25 infective infective JJ cord-329844-w969lczb 524 26 small small JJ cord-329844-w969lczb 524 27 loads load NNS cord-329844-w969lczb 524 28 of of IN cord-329844-w969lczb 524 29 virus virus NN cord-329844-w969lczb 524 30 rely rely VBP cord-329844-w969lczb 524 31 on on IN cord-329844-w969lczb 524 32 chance chance NN cord-329844-w969lczb 524 33 to to TO cord-329844-w969lczb 524 34 travel travel VB cord-329844-w969lczb 524 35 from from IN cord-329844-w969lczb 524 36 the the DT cord-329844-w969lczb 524 37 infecting infect VBG cord-329844-w969lczb 524 38 person person NN cord-329844-w969lczb 524 39 to to IN cord-329844-w969lczb 524 40 the the DT cord-329844-w969lczb 524 41 lung lung NN cord-329844-w969lczb 524 42 cell cell NN cord-329844-w969lczb 524 43 ACE2 ACE2 NNP cord-329844-w969lczb 524 44 receptor receptor NN cord-329844-w969lczb 524 45 of of IN cord-329844-w969lczb 524 46 the the DT cord-329844-w969lczb 524 47 next next JJ cord-329844-w969lczb 524 48 human human JJ cord-329844-w969lczb 524 49 host host NN cord-329844-w969lczb 524 50 . . . cord-329844-w969lczb 525 1 It -PRON- PRP cord-329844-w969lczb 525 2 is be VBZ cord-329844-w969lczb 525 3 as as RB cord-329844-w969lczb 525 4 yet yet RB cord-329844-w969lczb 525 5 unclear unclear JJ cord-329844-w969lczb 525 6 how how WRB cord-329844-w969lczb 525 7 many many JJ cord-329844-w969lczb 525 8 virus virus NN cord-329844-w969lczb 525 9 particles particle NNS cord-329844-w969lczb 525 10 of of IN cord-329844-w969lczb 525 11 SARS SARS NNP cord-329844-w969lczb 525 12 - - HYPH cord-329844-w969lczb 525 13 CoV-2 CoV-2 NNP cord-329844-w969lczb 525 14 are be VBP cord-329844-w969lczb 525 15 needed need VBN cord-329844-w969lczb 525 16 for for IN cord-329844-w969lczb 525 17 infection infection NN cord-329844-w969lczb 525 18 , , , cord-329844-w969lczb 525 19 but but CC cord-329844-w969lczb 525 20 the the DT cord-329844-w969lczb 525 21 virus virus NN cord-329844-w969lczb 525 22 is be VBZ cord-329844-w969lczb 525 23 clearly clearly RB cord-329844-w969lczb 525 24 very very RB cord-329844-w969lczb 525 25 contagious contagious JJ cord-329844-w969lczb 525 26 , , , cord-329844-w969lczb 525 27 and and CC cord-329844-w969lczb 525 28 this this DT cord-329844-w969lczb 525 29 may may MD cord-329844-w969lczb 525 30 be be VB cord-329844-w969lczb 525 31 because because IN cord-329844-w969lczb 525 32 rather rather RB cord-329844-w969lczb 525 33 few few JJ cord-329844-w969lczb 525 34 particles particle NNS cord-329844-w969lczb 525 35 are be VBP cord-329844-w969lczb 525 36 needed need VBN cord-329844-w969lczb 525 37 for for IN cord-329844-w969lczb 525 38 infection infection NN cord-329844-w969lczb 525 39 . . . cord-329844-w969lczb 526 1 In in IN cord-329844-w969lczb 526 2 any any DT cord-329844-w969lczb 526 3 event event NN cord-329844-w969lczb 526 4 , , , cord-329844-w969lczb 526 5 the the DT cord-329844-w969lczb 526 6 virus virus NN cord-329844-w969lczb 526 7 has have VBZ cord-329844-w969lczb 526 8 to to TO cord-329844-w969lczb 526 9 survive survive VB cord-329844-w969lczb 526 10 , , , cord-329844-w969lczb 526 11 and and CC cord-329844-w969lczb 526 12 ideally ideally RB cord-329844-w969lczb 526 13 even even RB cord-329844-w969lczb 526 14 benefit benefit VB cord-329844-w969lczb 526 15 for for IN cord-329844-w969lczb 526 16 its -PRON- PRP$ cord-329844-w969lczb 526 17 survival survival NN cord-329844-w969lczb 526 18 , , , cord-329844-w969lczb 526 19 stages stage NNS cord-329844-w969lczb 526 20 in in IN cord-329844-w969lczb 526 21 a a DT cord-329844-w969lczb 526 22 complex complex JJ cord-329844-w969lczb 526 23 journey journey NN cord-329844-w969lczb 526 24 in in IN cord-329844-w969lczb 526 25 mucus mucus NN cord-329844-w969lczb 526 26 of of IN cord-329844-w969lczb 526 27 a a DT cord-329844-w969lczb 526 28 sneeze sneeze NN cord-329844-w969lczb 526 29 or or CC cord-329844-w969lczb 526 30 on on IN cord-329844-w969lczb 526 31 hands hand NNS cord-329844-w969lczb 526 32 , , , cord-329844-w969lczb 526 33 face face NN cord-329844-w969lczb 526 34 , , , cord-329844-w969lczb 526 35 eye eye NN cord-329844-w969lczb 526 36 , , , cord-329844-w969lczb 526 37 nose nose NN cord-329844-w969lczb 526 38 , , , cord-329844-w969lczb 526 39 or or CC cord-329844-w969lczb 526 40 mouth mouth NN cord-329844-w969lczb 526 41 , , , cord-329844-w969lczb 526 42 and and CC cord-329844-w969lczb 526 43 in in IN cord-329844-w969lczb 526 44 the the DT cord-329844-w969lczb 526 45 various various JJ cord-329844-w969lczb 526 46 stages stage NNS cord-329844-w969lczb 526 47 of of IN cord-329844-w969lczb 526 48 the the DT cord-329844-w969lczb 526 49 airway airway NN cord-329844-w969lczb 526 50 . . . cord-329844-w969lczb 527 1 Initial initial JJ cord-329844-w969lczb 527 2 cell cell NN cord-329844-w969lczb 527 3 entry entry NN cord-329844-w969lczb 527 4 points point NNS cord-329844-w969lczb 527 5 are be VBP cord-329844-w969lczb 527 6 unlikely unlikely JJ cord-329844-w969lczb 527 7 to to TO cord-329844-w969lczb 527 8 be be VB cord-329844-w969lczb 527 9 only only RB cord-329844-w969lczb 527 10 the the DT cord-329844-w969lczb 527 11 lung lung NN cord-329844-w969lczb 527 12 epithelium epithelium NN cord-329844-w969lczb 527 13 . . . cord-329844-w969lczb 528 1 SARS SARS NNP cord-329844-w969lczb 528 2 - - HYPH cord-329844-w969lczb 528 3 CoV-2 CoV-2 NNP cord-329844-w969lczb 528 4 entry entry NN cord-329844-w969lczb 528 5 factors factor NNS cord-329844-w969lczb 528 6 are be VBP cord-329844-w969lczb 528 7 highly highly RB cord-329844-w969lczb 528 8 expressed express VBN cord-329844-w969lczb 528 9 in in IN cord-329844-w969lczb 528 10 nasal nasal JJ cord-329844-w969lczb 528 11 epithelial epithelial JJ cord-329844-w969lczb 528 12 cells cell NNS cord-329844-w969lczb 528 13 together together RB cord-329844-w969lczb 528 14 with with IN cord-329844-w969lczb 528 15 innate innate JJ cord-329844-w969lczb 528 16 immune immune JJ cord-329844-w969lczb 528 17 genes gene NNS cord-329844-w969lczb 528 18 [ [ -LRB- cord-329844-w969lczb 528 19 20 20 CD cord-329844-w969lczb 528 20 ] ] -RRB- cord-329844-w969lczb 528 21 . . . cord-329844-w969lczb 529 1 Viral viral JJ cord-329844-w969lczb 529 2 mechanisms mechanism NNS cord-329844-w969lczb 529 3 relating relate VBG cord-329844-w969lczb 529 4 to to IN cord-329844-w969lczb 529 5 these these DT cord-329844-w969lczb 529 6 various various JJ cord-329844-w969lczb 529 7 surfaces surface NNS cord-329844-w969lczb 529 8 could could MD cord-329844-w969lczb 529 9 be be VB cord-329844-w969lczb 529 10 fairly fairly RB cord-329844-w969lczb 529 11 sophisticated sophisticated JJ cord-329844-w969lczb 529 12 . . . cord-329844-w969lczb 530 1 In in IN cord-329844-w969lczb 530 2 biology biology NN cord-329844-w969lczb 530 3 in in IN cord-329844-w969lczb 530 4 general general JJ cord-329844-w969lczb 530 5 , , , cord-329844-w969lczb 530 6 flexibility flexibility NN cord-329844-w969lczb 530 7 in in IN cord-329844-w969lczb 530 8 carbohydrate carbohydrate NN cord-329844-w969lczb 530 9 recognition recognition NN cord-329844-w969lczb 530 10 contributes contribute VBZ cord-329844-w969lczb 530 11 to to IN cord-329844-w969lczb 530 12 the the DT cord-329844-w969lczb 530 13 targeting targeting JJ cord-329844-w969lczb 530 14 efficiency efficiency NN cord-329844-w969lczb 530 15 of of IN cord-329844-w969lczb 530 16 carbohydrate carbohydrate NN cord-329844-w969lczb 530 17 - - HYPH cord-329844-w969lczb 530 18 active active JJ cord-329844-w969lczb 530 19 enzymes enzyme NNS cord-329844-w969lczb 530 20 in in IN cord-329844-w969lczb 530 21 environments environment NNS cord-329844-w969lczb 530 22 where where WRB cord-329844-w969lczb 530 23 there there EX cord-329844-w969lczb 530 24 is be VBZ cord-329844-w969lczb 530 25 diverse diverse JJ cord-329844-w969lczb 530 26 range range NN cord-329844-w969lczb 530 27 of of IN cord-329844-w969lczb 530 28 saccharides saccharide NNS cord-329844-w969lczb 530 29 [ [ -LRB- cord-329844-w969lczb 530 30 18 18 CD cord-329844-w969lczb 530 31 ] ] -RRB- cord-329844-w969lczb 530 32 . . . cord-329844-w969lczb 531 1 In in IN cord-329844-w969lczb 531 2 a a DT cord-329844-w969lczb 531 3 virus virus NN cord-329844-w969lczb 531 4 , , , cord-329844-w969lczb 531 5 more more JJR cord-329844-w969lczb 531 6 than than IN cord-329844-w969lczb 531 7 one one CD cord-329844-w969lczb 531 8 saccharide saccharide NN cord-329844-w969lczb 531 9 - - HYPH cord-329844-w969lczb 531 10 binding bind VBG cord-329844-w969lczb 531 11 site site NN cord-329844-w969lczb 531 12 or or CC cord-329844-w969lczb 531 13 multiple multiple JJ cord-329844-w969lczb 531 14 sugar sugar NN cord-329844-w969lczb 531 15 binding bind VBG cord-329844-w969lczb 531 16 sites site NNS cord-329844-w969lczb 531 17 in in IN cord-329844-w969lczb 531 18 a a DT cord-329844-w969lczb 531 19 protein protein NN cord-329844-w969lczb 531 20 could could MD cord-329844-w969lczb 531 21 act act VB cord-329844-w969lczb 531 22 to to TO cord-329844-w969lczb 531 23 increase increase VB cord-329844-w969lczb 531 24 or or CC cord-329844-w969lczb 531 25 decrease decrease VB cord-329844-w969lczb 531 26 the the DT cord-329844-w969lczb 531 27 overall overall JJ cord-329844-w969lczb 531 28 affinity affinity NN cord-329844-w969lczb 531 29 and and CC cord-329844-w969lczb 531 30 increase increase NN cord-329844-w969lczb 531 31 or or CC cord-329844-w969lczb 531 32 decrease decrease VB cord-329844-w969lczb 531 33 virus virus NN cord-329844-w969lczb 531 34 mobility mobility NN cord-329844-w969lczb 531 35 at at IN cord-329844-w969lczb 531 36 different different JJ cord-329844-w969lczb 531 37 locations location NNS cord-329844-w969lczb 531 38 , , , cord-329844-w969lczb 531 39 while while IN cord-329844-w969lczb 531 40 conformational conformational JJ cord-329844-w969lczb 531 41 changes change NNS cord-329844-w969lczb 531 42 could could MD cord-329844-w969lczb 531 43 make make VB cord-329844-w969lczb 531 44 available available JJ cord-329844-w969lczb 531 45 some some DT cord-329844-w969lczb 531 46 sites site NNS cord-329844-w969lczb 531 47 and and CC cord-329844-w969lczb 531 48 not not RB cord-329844-w969lczb 531 49 others other NNS cord-329844-w969lczb 531 50 could could MD cord-329844-w969lczb 531 51 regulate regulate VB cord-329844-w969lczb 531 52 the the DT cord-329844-w969lczb 531 53 extent extent NN cord-329844-w969lczb 531 54 of of IN cord-329844-w969lczb 531 55 movement movement NN cord-329844-w969lczb 531 56 of of IN cord-329844-w969lczb 531 57 the the DT cord-329844-w969lczb 531 58 virus virus NN cord-329844-w969lczb 531 59 . . . cord-329844-w969lczb 532 1 Some some DT cord-329844-w969lczb 532 2 binding bind VBG cord-329844-w969lczb 532 3 sites site NNS cord-329844-w969lczb 532 4 have have VBP cord-329844-w969lczb 532 5 evolved evolve VBN cord-329844-w969lczb 532 6 to to TO cord-329844-w969lczb 532 7 distinguish distinguish VB cord-329844-w969lczb 532 8 not not RB cord-329844-w969lczb 532 9 just just RB cord-329844-w969lczb 532 10 the the DT cord-329844-w969lczb 532 11 sugar sugar NN cord-329844-w969lczb 532 12 residue residue NN cord-329844-w969lczb 532 13 components component NNS cord-329844-w969lczb 532 14 but but CC cord-329844-w969lczb 532 15 several several JJ cord-329844-w969lczb 532 16 types type NNS cord-329844-w969lczb 532 17 of of IN cord-329844-w969lczb 532 18 monosaccharide monosaccharide NN cord-329844-w969lczb 532 19 or or CC cord-329844-w969lczb 532 20 glycosidic glycosidic JJ cord-329844-w969lczb 532 21 bond bond NN cord-329844-w969lczb 532 22 linkage linkage NN cord-329844-w969lczb 532 23 . . . cord-329844-w969lczb 533 1 Once once RB cord-329844-w969lczb 533 2 having have VBG cord-329844-w969lczb 533 3 reached reach VBN cord-329844-w969lczb 533 4 the the DT cord-329844-w969lczb 533 5 vicinity vicinity NN cord-329844-w969lczb 533 6 of of IN cord-329844-w969lczb 533 7 a a DT cord-329844-w969lczb 533 8 cell cell NN cord-329844-w969lczb 533 9 with with IN cord-329844-w969lczb 533 10 an an DT cord-329844-w969lczb 533 11 ACE2 ACE2 NNP cord-329844-w969lczb 533 12 receptor receptor NN cord-329844-w969lczb 533 13 , , , cord-329844-w969lczb 533 14 the the DT cord-329844-w969lczb 533 15 virus virus NN cord-329844-w969lczb 533 16 still still RB cord-329844-w969lczb 533 17 needs need VBZ cord-329844-w969lczb 533 18 to to TO cord-329844-w969lczb 533 19 recognize recognize VB cord-329844-w969lczb 533 20 the the DT cord-329844-w969lczb 533 21 cell cell NN cord-329844-w969lczb 533 22 surface surface NN cord-329844-w969lczb 533 23 and and CC cord-329844-w969lczb 533 24 raft raft NN cord-329844-w969lczb 533 25 across across IN cord-329844-w969lczb 533 26 the the DT cord-329844-w969lczb 533 27 cell cell NN cord-329844-w969lczb 533 28 surface surface NN cord-329844-w969lczb 533 29 to to TO cord-329844-w969lczb 533 30 reach reach VB cord-329844-w969lczb 533 31 the the DT cord-329844-w969lczb 533 32 ACE2 ACE2 NNP cord-329844-w969lczb 533 33 receptor receptor NN cord-329844-w969lczb 533 34 . . . cord-329844-w969lczb 534 1 Fantani Fantani NNP cord-329844-w969lczb 534 2 et et NNP cord-329844-w969lczb 534 3 . . . cord-329844-w969lczb 535 1 al al NNP cord-329844-w969lczb 536 1 [ [ -LRB- cord-329844-w969lczb 536 2 17 17 CD cord-329844-w969lczb 536 3 ] ] -RRB- cord-329844-w969lczb 536 4 argued argue VBD cord-329844-w969lczb 536 5 that that IN cord-329844-w969lczb 536 6 a a DT cord-329844-w969lczb 536 7 new new JJ cord-329844-w969lczb 536 8 type type NN cord-329844-w969lczb 536 9 of of IN cord-329844-w969lczb 536 10 ganglioside ganglioside NN cord-329844-w969lczb 536 11 - - HYPH cord-329844-w969lczb 536 12 binding bind VBG cord-329844-w969lczb 536 13 domain domain NN cord-329844-w969lczb 536 14 exists exist VBZ cord-329844-w969lczb 536 15 at at IN cord-329844-w969lczb 536 16 the the DT cord-329844-w969lczb 536 17 tip tip NN cord-329844-w969lczb 536 18 of of IN cord-329844-w969lczb 536 19 the the DT cord-329844-w969lczb 536 20 N n CD cord-329844-w969lczb 536 21 - - HYPH cord-329844-w969lczb 536 22 terminal terminal NN cord-329844-w969lczb 536 23 domain domain NN cord-329844-w969lczb 536 24 of of IN cord-329844-w969lczb 536 25 the the DT cord-329844-w969lczb 536 26 SARS SARS NNP cord-329844-w969lczb 536 27 - - HYPH cord-329844-w969lczb 536 28 CoV-2 CoV-2 NNP cord-329844-w969lczb 536 29 S S NNP cord-329844-w969lczb 536 30 protein protein NN cord-329844-w969lczb 536 31 , , , cord-329844-w969lczb 536 32 and and CC cord-329844-w969lczb 536 33 that that IN cord-329844-w969lczb 536 34 the the DT cord-329844-w969lczb 536 35 subsequence subsequence NN cord-329844-w969lczb 536 36 111 111 CD cord-329844-w969lczb 536 37 - - SYM cord-329844-w969lczb 536 38 158 158 CD cord-329844-w969lczb 536 39 , , , cord-329844-w969lczb 536 40 conserved conserve VBN cord-329844-w969lczb 536 41 among among IN cord-329844-w969lczb 536 42 clinical clinical JJ cord-329844-w969lczb 536 43 isolates isolate NNS cord-329844-w969lczb 536 44 , , , cord-329844-w969lczb 536 45 may may MD cord-329844-w969lczb 536 46 improve improve VB cord-329844-w969lczb 536 47 attachment attachment NN cord-329844-w969lczb 536 48 of of IN cord-329844-w969lczb 536 49 the the DT cord-329844-w969lczb 536 50 virus virus NN cord-329844-w969lczb 536 51 to to IN cord-329844-w969lczb 536 52 lipid lipid NN cord-329844-w969lczb 536 53 rafts raft NNS cord-329844-w969lczb 536 54 and and CC cord-329844-w969lczb 536 55 facilitate facilitate VB cord-329844-w969lczb 536 56 contact contact NN cord-329844-w969lczb 536 57 with with IN cord-329844-w969lczb 536 58 the the DT cord-329844-w969lczb 536 59 ACE-2 ACE-2 NNP cord-329844-w969lczb 536 60 receptor receptor NN cord-329844-w969lczb 536 61 . . . cord-329844-w969lczb 537 1 This this DT cord-329844-w969lczb 537 2 study study NN cord-329844-w969lczb 537 3 also also RB cord-329844-w969lczb 537 4 showed show VBD cord-329844-w969lczb 537 5 that that IN cord-329844-w969lczb 537 6 , , , cord-329844-w969lczb 537 7 in in IN cord-329844-w969lczb 537 8 the the DT cord-329844-w969lczb 537 9 presence presence NN cord-329844-w969lczb 537 10 of of IN cord-329844-w969lczb 537 11 CLQ CLQ NNP cord-329844-w969lczb 537 12 or or CC cord-329844-w969lczb 537 13 its -PRON- PRP$ cord-329844-w969lczb 537 14 more more RBR cord-329844-w969lczb 537 15 active active JJ cord-329844-w969lczb 537 16 derivative derivative NN cord-329844-w969lczb 537 17 , , , cord-329844-w969lczb 537 18 hydroxychloroquine hydroxychloroquine NNP cord-329844-w969lczb 537 19 , , , cord-329844-w969lczb 537 20 the the DT cord-329844-w969lczb 537 21 spike spike NN cord-329844-w969lczb 537 22 protein protein NN cord-329844-w969lczb 537 23 is be VBZ cord-329844-w969lczb 537 24 no no RB cord-329844-w969lczb 537 25 longer longer RB cord-329844-w969lczb 537 26 able able JJ cord-329844-w969lczb 537 27 to to TO cord-329844-w969lczb 537 28 bind bind VB cord-329844-w969lczb 537 29 gangliosides ganglioside NNS cord-329844-w969lczb 537 30 [ [ -LRB- cord-329844-w969lczb 537 31 17 17 CD cord-329844-w969lczb 537 32 ] ] -RRB- cord-329844-w969lczb 537 33 . . . cord-329844-w969lczb 538 1 The the DT cord-329844-w969lczb 538 2 present present JJ cord-329844-w969lczb 538 3 study study NN cord-329844-w969lczb 538 4 does do VBZ cord-329844-w969lczb 538 5 not not RB cord-329844-w969lczb 538 6 support support VB cord-329844-w969lczb 538 7 ( ( -LRB- cord-329844-w969lczb 538 8 nor nor CC cord-329844-w969lczb 538 9 necessarily necessarily RB cord-329844-w969lczb 538 10 refute refute VB cord-329844-w969lczb 538 11 ) ) -RRB- cord-329844-w969lczb 538 12 their -PRON- PRP$ cord-329844-w969lczb 538 13 conclusions conclusion NNS cord-329844-w969lczb 538 14 in in IN cord-329844-w969lczb 538 15 terms term NNS cord-329844-w969lczb 538 16 of of IN cord-329844-w969lczb 538 17 such such JJ cord-329844-w969lczb 538 18 specific specific JJ cord-329844-w969lczb 538 19 details detail NNS cord-329844-w969lczb 538 20 , , , cord-329844-w969lczb 538 21 but but CC cord-329844-w969lczb 538 22 the the DT cord-329844-w969lczb 538 23 general general JJ cord-329844-w969lczb 538 24 argument argument NN cord-329844-w969lczb 538 25 concerning concern VBG cord-329844-w969lczb 538 26 guidance guidance NN cord-329844-w969lczb 538 27 to to IN cord-329844-w969lczb 538 28 the the DT cord-329844-w969lczb 538 29 ACE-2 ACE-2 NNP cord-329844-w969lczb 538 30 receptor receptor NN cord-329844-w969lczb 538 31 is be VBZ cord-329844-w969lczb 538 32 compatible compatible JJ cord-329844-w969lczb 538 33 . . . cord-329844-w969lczb 539 1 Very very RB cord-329844-w969lczb 539 2 recently recently RB cord-329844-w969lczb 539 3 Milanetti Milanetti NNP cord-329844-w969lczb 539 4 and and CC cord-329844-w969lczb 539 5 colleagues colleague NNS cord-329844-w969lczb 539 6 have have VBP cord-329844-w969lczb 539 7 made make VBN cord-329844-w969lczb 539 8 available available JJ cord-329844-w969lczb 539 9 a a DT cord-329844-w969lczb 539 10 preprint preprint NN cord-329844-w969lczb 539 11 [ [ -LRB- cord-329844-w969lczb 539 12 30 30 CD cord-329844-w969lczb 539 13 ] ] -RRB- cord-329844-w969lczb 539 14 that that WDT cord-329844-w969lczb 539 15 is be VBZ cord-329844-w969lczb 539 16 tune tune NN cord-329844-w969lczb 539 17 with with IN cord-329844-w969lczb 539 18 such such JJ cord-329844-w969lczb 539 19 ideas idea NNS cord-329844-w969lczb 539 20 , , , cord-329844-w969lczb 539 21 and and CC cord-329844-w969lczb 539 22 specifically specifically RB cord-329844-w969lczb 539 23 states state VBZ cord-329844-w969lczb 539 24 that that IN cord-329844-w969lczb 539 25 binding bind VBG cord-329844-w969lczb 539 26 silvic silvic JJ cord-329844-w969lczb 539 27 acids acid NNS cord-329844-w969lczb 539 28 provides provide VBZ cord-329844-w969lczb 539 29 a a DT cord-329844-w969lczb 539 30 second second JJ cord-329844-w969lczb 539 31 means mean NNS cord-329844-w969lczb 539 32 of of IN cord-329844-w969lczb 539 33 entry entry NN cord-329844-w969lczb 539 34 , , , cord-329844-w969lczb 539 35 other other JJ cord-329844-w969lczb 539 36 than than IN cord-329844-w969lczb 539 37 ACE2 ACE2 NNP cord-329844-w969lczb 539 38 . . . cord-329844-w969lczb 540 1 Rather rather RB cord-329844-w969lczb 540 2 like like IN cord-329844-w969lczb 540 3 the the DT cord-329844-w969lczb 540 4 approach approach NN cord-329844-w969lczb 540 5 of of IN cord-329844-w969lczb 540 6 Thornton Thornton NNP cord-329844-w969lczb 540 7 et et NNP cord-329844-w969lczb 540 8 al al NNP cord-329844-w969lczb 540 9 . . . cord-329844-w969lczb 541 1 [ [ -LRB- cord-329844-w969lczb 541 2 19 19 CD cord-329844-w969lczb 541 3 ] ] -RRB- cord-329844-w969lczb 541 4 , , , cord-329844-w969lczb 541 5 this this DT cord-329844-w969lczb 541 6 is be VBZ cord-329844-w969lczb 541 7 based base VBN cord-329844-w969lczb 541 8 more more RBR cord-329844-w969lczb 541 9 on on IN cord-329844-w969lczb 541 10 interactions interaction NNS cord-329844-w969lczb 541 11 between between IN cord-329844-w969lczb 541 12 surfaces surface NNS cord-329844-w969lczb 541 13 of of IN cord-329844-w969lczb 541 14 molecules molecule NNS cord-329844-w969lczb 541 15 in in IN cord-329844-w969lczb 541 16 three three CD cord-329844-w969lczb 541 17 dimensional dimensional JJ cord-329844-w969lczb 541 18 space space NN cord-329844-w969lczb 541 19 . . . cord-329844-w969lczb 542 1 The the DT cord-329844-w969lczb 542 2 results result NNS cord-329844-w969lczb 542 3 and and CC cord-329844-w969lczb 542 4 conclusions conclusion NNS cord-329844-w969lczb 542 5 of of IN cord-329844-w969lczb 542 6 this this DT cord-329844-w969lczb 542 7 study study NN cord-329844-w969lczb 542 8 are be VBP cord-329844-w969lczb 542 9 speculative speculative JJ cord-329844-w969lczb 542 10 in in IN cord-329844-w969lczb 542 11 the the DT cord-329844-w969lczb 542 12 sense sense NN cord-329844-w969lczb 542 13 that that IN cord-329844-w969lczb 542 14 they -PRON- PRP cord-329844-w969lczb 542 15 are be VBP cord-329844-w969lczb 542 16 applications application NNS cord-329844-w969lczb 542 17 of of IN cord-329844-w969lczb 542 18 computers computer NNS cord-329844-w969lczb 542 19 ( ( -LRB- cord-329844-w969lczb 542 20 using use VBG cord-329844-w969lczb 542 21 the the DT cord-329844-w969lczb 542 22 techniques technique NNS cord-329844-w969lczb 542 23 of of IN cord-329844-w969lczb 542 24 bioinformatics bioinformatic NNS cord-329844-w969lczb 542 25 and and CC cord-329844-w969lczb 542 26 a a DT cord-329844-w969lczb 542 27 new new JJ cord-329844-w969lczb 542 28 predictive predictive JJ cord-329844-w969lczb 542 29 method method NN cord-329844-w969lczb 542 30 ) ) -RRB- cord-329844-w969lczb 542 31 , , , cord-329844-w969lczb 542 32 and and CC cord-329844-w969lczb 542 33 hence hence RB cord-329844-w969lczb 542 34 they -PRON- PRP cord-329844-w969lczb 542 35 are be VBP cord-329844-w969lczb 542 36 essentially essentially RB cord-329844-w969lczb 542 37 theoretical theoretical JJ cord-329844-w969lczb 542 38 . . . cord-329844-w969lczb 543 1 Their -PRON- PRP$ cord-329844-w969lczb 543 2 role role NN cord-329844-w969lczb 543 3 has have VBZ cord-329844-w969lczb 543 4 been be VBN cord-329844-w969lczb 543 5 to to TO cord-329844-w969lczb 543 6 highlight highlight VB cord-329844-w969lczb 543 7 the the DT cord-329844-w969lczb 543 8 likelihood likelihood NN cord-329844-w969lczb 543 9 that that IN cord-329844-w969lczb 543 10 the the DT cord-329844-w969lczb 543 11 SARS SARS NNP cord-329844-w969lczb 543 12 - - HYPH cord-329844-w969lczb 543 13 CoV-2 CoV-2 NNP cord-329844-w969lczb 543 14 spike spike NN cord-329844-w969lczb 543 15 has have VBZ cord-329844-w969lczb 543 16 a a DT cord-329844-w969lczb 543 17 biological biological JJ cord-329844-w969lczb 543 18 function function NN cord-329844-w969lczb 543 19 of of IN cord-329844-w969lczb 543 20 binding bind VBG cord-329844-w969lczb 543 21 host host NN cord-329844-w969lczb 543 22 cell cell NN cord-329844-w969lczb 543 23 sialic sialic NN cord-329844-w969lczb 543 24 acid acid NN cord-329844-w969lczb 543 25 glycans glycan NNS cord-329844-w969lczb 543 26 ( ( -LRB- cord-329844-w969lczb 543 27 and and CC cord-329844-w969lczb 543 28 probably probably RB cord-329844-w969lczb 543 29 across across IN cord-329844-w969lczb 543 30 cells cell NNS cord-329844-w969lczb 543 31 surfaces surface NNS cord-329844-w969lczb 543 32 by by IN cord-329844-w969lczb 543 33 that that DT cord-329844-w969lczb 543 34 means means NN cord-329844-w969lczb 543 35 , , , cord-329844-w969lczb 543 36 as as IN cord-329844-w969lczb 543 37 discussed discuss VBN cord-329844-w969lczb 543 38 below below RB cord-329844-w969lczb 543 39 ) ) -RRB- cord-329844-w969lczb 543 40 . . . cord-329844-w969lczb 544 1 In in IN cord-329844-w969lczb 544 2 particular particular JJ cord-329844-w969lczb 544 3 , , , cord-329844-w969lczb 544 4 a a DT cord-329844-w969lczb 544 5 domain domain NN cord-329844-w969lczb 544 6 in in IN cord-329844-w969lczb 544 7 the the DT cord-329844-w969lczb 544 8 cap cap NN cord-329844-w969lczb 544 9 or or CC cord-329844-w969lczb 544 10 knob knob NN cord-329844-w969lczb 544 11 of of IN cord-329844-w969lczb 544 12 the the DT cord-329844-w969lczb 544 13 SARS SARS NNP cord-329844-w969lczb 544 14 - - HYPH cord-329844-w969lczb 544 15 CoV-2 CoV-2 NNP cord-329844-w969lczb 544 16 spike spike NN cord-329844-w969lczb 544 17 , , , cord-329844-w969lczb 544 18 which which WDT cord-329844-w969lczb 544 19 has have VBZ cord-329844-w969lczb 544 20 so so RB cord-329844-w969lczb 544 21 far far RB cord-329844-w969lczb 544 22 been be VBN cord-329844-w969lczb 544 23 somewhat somewhat RB cord-329844-w969lczb 544 24 neglected neglect VBN cord-329844-w969lczb 544 25 , , , cord-329844-w969lczb 544 26 is be VBZ cord-329844-w969lczb 544 27 involved involve VBN cord-329844-w969lczb 544 28 in in IN cord-329844-w969lczb 544 29 the the DT cord-329844-w969lczb 544 30 non non JJ cord-329844-w969lczb 544 31 - - JJ cord-329844-w969lczb 544 32 covalent covalent JJ cord-329844-w969lczb 544 33 binding binding NN cord-329844-w969lczb 544 34 of of IN cord-329844-w969lczb 544 35 host host NN cord-329844-w969lczb 544 36 sialic sialic NN cord-329844-w969lczb 544 37 acid acid NN cord-329844-w969lczb 544 38 glycans glycan NNS cord-329844-w969lczb 544 39 . . . cord-329844-w969lczb 545 1 It -PRON- PRP cord-329844-w969lczb 545 2 is be VBZ cord-329844-w969lczb 545 3 perhaps perhaps RB cord-329844-w969lczb 545 4 curious curious JJ cord-329844-w969lczb 545 5 that that IN cord-329844-w969lczb 545 6 subsequences subsequence NNS cord-329844-w969lczb 545 7 found find VBN cord-329844-w969lczb 545 8 as as IN cord-329844-w969lczb 545 9 conserved conserve VBN cord-329844-w969lczb 545 10 by by IN cord-329844-w969lczb 545 11 use use NN cord-329844-w969lczb 545 12 of of IN cord-329844-w969lczb 545 13 bioinformatics bioinformatics NN cord-329844-w969lczb 545 14 tools tool NNS cord-329844-w969lczb 545 15 such such JJ cord-329844-w969lczb 545 16 BLASTp BLASTp NNS cord-329844-w969lczb 545 17 and and CC cord-329844-w969lczb 545 18 Clustal Clustal NNP cord-329844-w969lczb 545 19 Omega Omega NNP cord-329844-w969lczb 545 20 ( ( -LRB- cord-329844-w969lczb 545 21 also also RB cord-329844-w969lczb 545 22 used use VBN cord-329844-w969lczb 545 23 here here RB cord-329844-w969lczb 545 24 as as IN cord-329844-w969lczb 545 25 described describe VBN cord-329844-w969lczb 545 26 in in IN cord-329844-w969lczb 545 27 Methods Methods NNPS cord-329844-w969lczb 545 28 Section Section NNP cord-329844-w969lczb 545 29 4.1 4.1 CD cord-329844-w969lczb 545 30 ) ) -RRB- cord-329844-w969lczb 545 31 , , , cord-329844-w969lczb 545 32 or or CC cord-329844-w969lczb 545 33 detected detect VBN cord-329844-w969lczb 545 34 as as IN cord-329844-w969lczb 545 35 a a DT cord-329844-w969lczb 545 36 known known JJ cord-329844-w969lczb 545 37 or or CC cord-329844-w969lczb 545 38 new new JJ cord-329844-w969lczb 545 39 functional functional JJ cord-329844-w969lczb 545 40 motif motif NN cord-329844-w969lczb 545 41 , , , cord-329844-w969lczb 545 42 often often RB cord-329844-w969lczb 545 43 seem seem VBP cord-329844-w969lczb 545 44 in in IN cord-329844-w969lczb 545 45 the the DT cord-329844-w969lczb 545 46 literature literature NN cord-329844-w969lczb 545 47 to to TO cord-329844-w969lczb 545 48 be be VB cord-329844-w969lczb 545 49 considered consider VBN cord-329844-w969lczb 545 50 as as IN cord-329844-w969lczb 545 51 having have VBG cord-329844-w969lczb 545 52 the the DT cord-329844-w969lczb 545 53 status status NN cord-329844-w969lczb 545 54 of of IN cord-329844-w969lczb 545 55 experiment experiment NN cord-329844-w969lczb 545 56 or or CC cord-329844-w969lczb 545 57 observation observation NN cord-329844-w969lczb 545 58 , , , cord-329844-w969lczb 545 59 while while IN cord-329844-w969lczb 545 60 consideration consideration NN cord-329844-w969lczb 545 61 of of IN cord-329844-w969lczb 545 62 more more JJR cord-329844-w969lczb 545 63 complex complex JJ cord-329844-w969lczb 545 64 patterns pattern NNS cord-329844-w969lczb 545 65 with with IN cord-329844-w969lczb 545 66 more more JJR cord-329844-w969lczb 545 67 sequence sequence NN cord-329844-w969lczb 545 68 options option NNS cord-329844-w969lczb 545 69 tend tend VBP cord-329844-w969lczb 545 70 to to TO cord-329844-w969lczb 545 71 be be VB cord-329844-w969lczb 545 72 treated treat VBN cord-329844-w969lczb 545 73 as as IN cord-329844-w969lczb 545 74 theory theory NN cord-329844-w969lczb 545 75 and and CC cord-329844-w969lczb 545 76 prediction prediction NN cord-329844-w969lczb 545 77 . . . cord-329844-w969lczb 546 1 This this DT cord-329844-w969lczb 546 2 caution caution NN cord-329844-w969lczb 546 3 is be VBZ cord-329844-w969lczb 546 4 justified justify VBN cord-329844-w969lczb 546 5 in in IN cord-329844-w969lczb 546 6 the the DT cord-329844-w969lczb 546 7 present present JJ cord-329844-w969lczb 546 8 study study NN cord-329844-w969lczb 546 9 because because IN cord-329844-w969lczb 546 10 further further JJ cord-329844-w969lczb 546 11 study study NN cord-329844-w969lczb 546 12 and and CC cord-329844-w969lczb 546 13 confirmation confirmation NN cord-329844-w969lczb 546 14 is be VBZ cord-329844-w969lczb 546 15 required require VBN cord-329844-w969lczb 546 16 along along IN cord-329844-w969lczb 546 17 the the DT cord-329844-w969lczb 546 18 lines line NNS cord-329844-w969lczb 546 19 discussed discuss VBN cord-329844-w969lczb 546 20 in in IN cord-329844-w969lczb 546 21 Discussion Discussion NNP cord-329844-w969lczb 546 22 section section NN cord-329844-w969lczb 546 23 5 5 CD cord-329844-w969lczb 546 24 above above RB cord-329844-w969lczb 546 25 . . . cord-329844-w969lczb 547 1 above above RB cord-329844-w969lczb 547 2 . . . cord-329844-w969lczb 548 1 To to IN cord-329844-w969lczb 548 2 the the DT cord-329844-w969lczb 548 3 extent extent NN cord-329844-w969lczb 548 4 that that IN cord-329844-w969lczb 548 5 it -PRON- PRP cord-329844-w969lczb 548 6 is be VBZ cord-329844-w969lczb 548 7 a a DT cord-329844-w969lczb 548 8 prediction prediction NN cord-329844-w969lczb 548 9 , , , cord-329844-w969lczb 548 10 it -PRON- PRP cord-329844-w969lczb 548 11 is be VBZ cord-329844-w969lczb 548 12 a a DT cord-329844-w969lczb 548 13 prediction prediction NN cord-329844-w969lczb 548 14 for for IN cord-329844-w969lczb 548 15 SARS SARS NNP cord-329844-w969lczb 548 16 - - HYPH cord-329844-w969lczb 548 17 CoV-2 CoV-2 NNP cord-329844-w969lczb 548 18 made make VBD cord-329844-w969lczb 548 19 in in IN cord-329844-w969lczb 548 20 advance advance NN cord-329844-w969lczb 548 21 of of IN cord-329844-w969lczb 548 22 experiment experiment NN cord-329844-w969lczb 548 23 in in IN cord-329844-w969lczb 548 24 order order NN cord-329844-w969lczb 548 25 to to TO cord-329844-w969lczb 548 26 provide provide VB cord-329844-w969lczb 548 27 an an DT cord-329844-w969lczb 548 28 objective objective JJ cord-329844-w969lczb 548 29 and and CC cord-329844-w969lczb 548 30 fair fair JJ cord-329844-w969lczb 548 31 test test NN cord-329844-w969lczb 548 32 of of IN cord-329844-w969lczb 548 33 the the DT cord-329844-w969lczb 548 34 methodology methodology NN cord-329844-w969lczb 548 35 and and CC cord-329844-w969lczb 548 36 it -PRON- PRP cord-329844-w969lczb 548 37 is be VBZ cord-329844-w969lczb 548 38 hoped hope VBN cord-329844-w969lczb 548 39 that that IN cord-329844-w969lczb 548 40 it -PRON- PRP cord-329844-w969lczb 548 41 will will MD cord-329844-w969lczb 548 42 stimulate stimulate VB cord-329844-w969lczb 548 43 experimental experimental JJ cord-329844-w969lczb 548 44 study study NN cord-329844-w969lczb 548 45 in in IN cord-329844-w969lczb 548 46 this this DT cord-329844-w969lczb 548 47 area area NN cord-329844-w969lczb 548 48 whether whether IN cord-329844-w969lczb 548 49 the the DT cord-329844-w969lczb 548 50 experiments experiment NNS cord-329844-w969lczb 548 51 confirm confirm VBP cord-329844-w969lczb 548 52 or or CC cord-329844-w969lczb 548 53 refute refute VBP cord-329844-w969lczb 548 54 that that DT cord-329844-w969lczb 548 55 prediction prediction NN cord-329844-w969lczb 548 56 . . . cord-329844-w969lczb 549 1 Either either DT cord-329844-w969lczb 549 2 result result NN cord-329844-w969lczb 549 3 would would MD cord-329844-w969lczb 549 4 likely likely RB cord-329844-w969lczb 549 5 be be VB cord-329844-w969lczb 549 6 of of IN cord-329844-w969lczb 549 7 ultimate ultimate JJ cord-329844-w969lczb 549 8 medical medical JJ cord-329844-w969lczb 549 9 importance importance NN cord-329844-w969lczb 549 10 . . . cord-329844-w969lczb 550 1 This this DT cord-329844-w969lczb 550 2 is be VBZ cord-329844-w969lczb 550 3 essentially essentially RB cord-329844-w969lczb 550 4 typical typical JJ cord-329844-w969lczb 550 5 of of IN cord-329844-w969lczb 550 6 the the DT cord-329844-w969lczb 550 7 more more RBR cord-329844-w969lczb 550 8 interesting interesting JJ cord-329844-w969lczb 550 9 roles role NNS cord-329844-w969lczb 550 10 of of IN cord-329844-w969lczb 550 11 computers computer NNS cord-329844-w969lczb 550 12 in in IN cord-329844-w969lczb 550 13 biomedical biomedical JJ cord-329844-w969lczb 550 14 research research NN cord-329844-w969lczb 550 15 , , , cord-329844-w969lczb 550 16 although although IN cord-329844-w969lczb 550 17 the the DT cord-329844-w969lczb 550 18 general general JJ cord-329844-w969lczb 550 19 infrastructure infrastructure NN cord-329844-w969lczb 550 20 and and CC cord-329844-w969lczb 550 21 support support NN cord-329844-w969lczb 550 22 that that IN cord-329844-w969lczb 550 23 they -PRON- PRP cord-329844-w969lczb 550 24 provide provide VBP cord-329844-w969lczb 550 25 for for IN cord-329844-w969lczb 550 26 more more JJR cord-329844-w969lczb 550 27 routine routine JJ cord-329844-w969lczb 550 28 tasks task NNS cord-329844-w969lczb 550 29 is be VBZ cord-329844-w969lczb 550 30 of of IN cord-329844-w969lczb 550 31 course course NN cord-329844-w969lczb 550 32 of of IN cord-329844-w969lczb 550 33 great great JJ cord-329844-w969lczb 550 34 importance importance NN cord-329844-w969lczb 550 35 . . . cord-329844-w969lczb 551 1 The the DT cord-329844-w969lczb 551 2 present present JJ cord-329844-w969lczb 551 3 paper paper NN cord-329844-w969lczb 551 4 possibly possibly RB cord-329844-w969lczb 551 5 still still RB cord-329844-w969lczb 551 6 stands stand VBZ cord-329844-w969lczb 551 7 as as IN cord-329844-w969lczb 551 8 the the DT cord-329844-w969lczb 551 9 first first JJ cord-329844-w969lczb 551 10 reported report VBN cord-329844-w969lczb 551 11 attempt attempt NN cord-329844-w969lczb 551 12 to to TO cord-329844-w969lczb 551 13 establish establish VB cord-329844-w969lczb 551 14 means mean NNS cord-329844-w969lczb 551 15 of of IN cord-329844-w969lczb 551 16 making make VBG cord-329844-w969lczb 551 17 use use NN cord-329844-w969lczb 551 18 of of IN cord-329844-w969lczb 551 19 sequence sequence NN cord-329844-w969lczb 551 20 motifs motif NNS cord-329844-w969lczb 551 21 that that WDT cord-329844-w969lczb 551 22 could could MD cord-329844-w969lczb 551 23 be be VB cord-329844-w969lczb 551 24 recognized recognize VBN cord-329844-w969lczb 551 25 between between IN cord-329844-w969lczb 551 26 strains strain NNS cord-329844-w969lczb 551 27 , , , cord-329844-w969lczb 551 28 albeit albeit IN cord-329844-w969lczb 551 29 that that IN cord-329844-w969lczb 551 30 the the DT cord-329844-w969lczb 551 31 order order NN cord-329844-w969lczb 551 32 and and CC cord-329844-w969lczb 551 33 to to IN cord-329844-w969lczb 551 34 some some DT cord-329844-w969lczb 551 35 extent extent NN cord-329844-w969lczb 551 36 precise precise JJ cord-329844-w969lczb 551 37 nature nature NN cord-329844-w969lczb 551 38 of of IN cord-329844-w969lczb 551 39 the the DT cord-329844-w969lczb 551 40 amino amino NN cord-329844-w969lczb 551 41 acid acid NN cord-329844-w969lczb 551 42 residues residue NNS cord-329844-w969lczb 551 43 of of IN cord-329844-w969lczb 551 44 amino amino NN cord-329844-w969lczb 551 45 acid acid NN cord-329844-w969lczb 551 46 residues residue NNS cord-329844-w969lczb 551 47 appears appear VBZ cord-329844-w969lczb 551 48 less less RBR cord-329844-w969lczb 551 49 important important JJ cord-329844-w969lczb 551 50 , , , cord-329844-w969lczb 551 51 or or CC cord-329844-w969lczb 551 52 perhaps perhaps RB cord-329844-w969lczb 551 53 more more RBR cord-329844-w969lczb 551 54 subtle subtle JJ cord-329844-w969lczb 551 55 , , , cord-329844-w969lczb 551 56 than than IN cord-329844-w969lczb 551 57 has have VBZ cord-329844-w969lczb 551 58 been be VBN cord-329844-w969lczb 551 59 considered consider VBN cord-329844-w969lczb 551 60 in in IN cord-329844-w969lczb 551 61 previous previous JJ cord-329844-w969lczb 551 62 papers paper NNS cord-329844-w969lczb 551 63 in in IN cord-329844-w969lczb 551 64 this this DT cord-329844-w969lczb 551 65 series series NN cord-329844-w969lczb 551 66 [ [ -LRB- cord-329844-w969lczb 551 67 4 4 CD cord-329844-w969lczb 551 68 , , , cord-329844-w969lczb 551 69 5 5 CD cord-329844-w969lczb 551 70 ] ] -RRB- cord-329844-w969lczb 551 71 , , , cord-329844-w969lczb 551 72 which which WDT cord-329844-w969lczb 551 73 is be VBZ cord-329844-w969lczb 551 74 why why WRB cord-329844-w969lczb 551 75 it -PRON- PRP cord-329844-w969lczb 551 76 required require VBD cord-329844-w969lczb 551 77 the the DT cord-329844-w969lczb 551 78 development development NN cord-329844-w969lczb 551 79 of of IN cord-329844-w969lczb 551 80 the the DT cord-329844-w969lczb 551 81 predictive predictive JJ cord-329844-w969lczb 551 82 technique technique NN cord-329844-w969lczb 551 83 ( ( -LRB- cord-329844-w969lczb 551 84 SABR SABR NNP cord-329844-w969lczb 551 85 - - HYPH cord-329844-w969lczb 551 86 P p NN cord-329844-w969lczb 551 87 ) ) -RRB- cord-329844-w969lczb 551 88 . . . cord-329844-w969lczb 552 1 This this DT cord-329844-w969lczb 552 2 will will MD cord-329844-w969lczb 552 3 be be VB cord-329844-w969lczb 552 4 advanced advance VBN cord-329844-w969lczb 552 5 in in IN cord-329844-w969lczb 552 6 future future JJ cord-329844-w969lczb 552 7 work work NN cord-329844-w969lczb 552 8 , , , cord-329844-w969lczb 552 9 but but CC cord-329844-w969lczb 552 10 the the DT cord-329844-w969lczb 552 11 present present JJ cord-329844-w969lczb 552 12 method method NN cord-329844-w969lczb 552 13 already already RB cord-329844-w969lczb 552 14 helps help VBZ cord-329844-w969lczb 552 15 to to TO cord-329844-w969lczb 552 16 make make VB cord-329844-w969lczb 552 17 quick quick JJ cord-329844-w969lczb 552 18 comparisons comparison NNS cord-329844-w969lczb 552 19 between between IN cord-329844-w969lczb 552 20 SARS SARS NNP cord-329844-w969lczb 552 21 - - HYPH cord-329844-w969lczb 552 22 CoV-2 CoV-2 NNP cord-329844-w969lczb 552 23 sequences sequence NNS cord-329844-w969lczb 552 24 and and CC cord-329844-w969lczb 552 25 to to TO cord-329844-w969lczb 552 26 consider consider VB cord-329844-w969lczb 552 27 the the DT cord-329844-w969lczb 552 28 effects effect NNS cord-329844-w969lczb 552 29 of of IN cord-329844-w969lczb 552 30 viral viral JJ cord-329844-w969lczb 552 31 mutations mutation NNS cord-329844-w969lczb 552 32 . . . cord-329844-w969lczb 553 1 However however RB cord-329844-w969lczb 553 2 , , , cord-329844-w969lczb 553 3 it -PRON- PRP cord-329844-w969lczb 553 4 was be VBD cord-329844-w969lczb 553 5 surprising surprising JJ cord-329844-w969lczb 553 6 that that IN cord-329844-w969lczb 553 7 a a DT cord-329844-w969lczb 553 8 very very RB cord-329844-w969lczb 553 9 simple simple JJ cord-329844-w969lczb 553 10 approach approach NN cord-329844-w969lczb 553 11 was be VBD cord-329844-w969lczb 553 12 so so RB cord-329844-w969lczb 553 13 useful useful JJ cord-329844-w969lczb 553 14 , , , cord-329844-w969lczb 553 15 and and CC cord-329844-w969lczb 553 16 it -PRON- PRP cord-329844-w969lczb 553 17 can can MD cord-329844-w969lczb 553 18 easily easily RB cord-329844-w969lczb 553 19 be be VB cord-329844-w969lczb 553 20 reproduced reproduce VBN cord-329844-w969lczb 553 21 in in IN cord-329844-w969lczb 553 22 a a DT cord-329844-w969lczb 553 23 very very RB cord-329844-w969lczb 553 24 few few JJ cord-329844-w969lczb 553 25 lines line NNS cord-329844-w969lczb 553 26 of of IN cord-329844-w969lczb 553 27 computer computer NN cord-329844-w969lczb 553 28 program program NN cord-329844-w969lczb 553 29 . . . cord-329844-w969lczb 554 1 The the DT cord-329844-w969lczb 554 2 important important JJ cord-329844-w969lczb 554 3 consequence consequence NN cord-329844-w969lczb 554 4 of of IN cord-329844-w969lczb 554 5 the the DT cord-329844-w969lczb 554 6 present present JJ cord-329844-w969lczb 554 7 study study NN cord-329844-w969lczb 554 8 , , , cord-329844-w969lczb 554 9 however however RB cord-329844-w969lczb 554 10 , , , cord-329844-w969lczb 554 11 is be VBZ cord-329844-w969lczb 554 12 that that IN cord-329844-w969lczb 554 13 there there EX cord-329844-w969lczb 554 14 are be VBP cord-329844-w969lczb 554 15 already already RB cord-329844-w969lczb 554 16 a a DT cord-329844-w969lczb 554 17 variety variety NN cord-329844-w969lczb 554 18 of of IN cord-329844-w969lczb 554 19 inhibitors inhibitor NNS cord-329844-w969lczb 554 20 of of IN cord-329844-w969lczb 554 21 sialic sialic JJ cord-329844-w969lczb 554 22 acid acid NN cord-329844-w969lczb 554 23 binding binding NN cord-329844-w969lczb 554 24 that that WDT cord-329844-w969lczb 554 25 may may MD cord-329844-w969lczb 554 26 serve serve VB cord-329844-w969lczb 554 27 as as IN cord-329844-w969lczb 554 28 anti anti JJ cord-329844-w969lczb 554 29 - - JJ cord-329844-w969lczb 554 30 viral viral JJ cord-329844-w969lczb 554 31 agents agent NNS cord-329844-w969lczb 554 32 , , , cord-329844-w969lczb 554 33 and and CC cord-329844-w969lczb 554 34 this this DT cord-329844-w969lczb 554 35 will will MD cord-329844-w969lczb 554 36 be be VB cord-329844-w969lczb 554 37 examined examine VBN cord-329844-w969lczb 554 38 elsewhere elsewhere RB cord-329844-w969lczb 554 39 . . . cord-329844-w969lczb 555 1 • • NNP cord-329844-w969lczb 556 1 This this DT cord-329844-w969lczb 556 2 paper paper NN cord-329844-w969lczb 556 3 extends extend VBZ cord-329844-w969lczb 556 4 the the DT cord-329844-w969lczb 556 5 studies study NNS cord-329844-w969lczb 556 6 of of IN cord-329844-w969lczb 556 7 the the DT cord-329844-w969lczb 556 8 author author NN cord-329844-w969lczb 556 9 's 's POS cord-329844-w969lczb 556 10 previous previous JJ cord-329844-w969lczb 556 11 SARS SARS NNP cord-329844-w969lczb 556 12 - - HYPH cord-329844-w969lczb 556 13 CoV-2 CoV-2 NNP cord-329844-w969lczb 556 14 papers paper NNS cord-329844-w969lczb 556 15 . . . cord-329844-w969lczb 557 1 • • NNP cord-329844-w969lczb 558 1 Designing design VBG cord-329844-w969lczb 558 2 vaccine vaccine NN cord-329844-w969lczb 558 3 and and CC cord-329844-w969lczb 558 4 drugs drug NNS cord-329844-w969lczb 558 5 must must MD cord-329844-w969lczb 558 6 seek seek VB cord-329844-w969lczb 558 7 to to TO cord-329844-w969lczb 558 8 avoid avoid VB cord-329844-w969lczb 558 9 escape escape NN cord-329844-w969lczb 558 10 mutations mutation NNS cord-329844-w969lczb 558 11 . . . cord-329844-w969lczb 559 1 • • NNP cord-329844-w969lczb 560 1 Strangely strangely RB cord-329844-w969lczb 560 2 , , , cord-329844-w969lczb 560 3 SARS SARS NNP cord-329844-w969lczb 560 4 - - HYPH cord-329844-w969lczb 560 5 CoV CoV NNP cord-329844-w969lczb 560 6 and and CC cord-329844-w969lczb 560 7 SARS SARS NNP cord-329844-w969lczb 560 8 - - HYPH cord-329844-w969lczb 560 9 CoV-2 CoV-2 NNP cord-329844-w969lczb 560 10 appear appear VBP cord-329844-w969lczb 560 11 to to TO cord-329844-w969lczb 560 12 lack lack VB cord-329844-w969lczb 560 13 sialic sialic NN cord-329844-w969lczb 560 14 acid acid NN cord-329844-w969lczb 560 15 binding binding NN cord-329844-w969lczb 560 16 functions function NNS cord-329844-w969lczb 560 17 . . . cord-329844-w969lczb 561 1 • • NNP cord-329844-w969lczb 562 1 Sequence sequence NN cord-329844-w969lczb 562 2 motifs motif NNS cord-329844-w969lczb 562 3 are be VBP cord-329844-w969lczb 562 4 found find VBN cord-329844-w969lczb 562 5 , , , cord-329844-w969lczb 562 6 but but CC cord-329844-w969lczb 562 7 they -PRON- PRP cord-329844-w969lczb 562 8 require require VBP cord-329844-w969lczb 562 9 a a DT cord-329844-w969lczb 562 10 simple simple JJ cord-329844-w969lczb 562 11 prediction prediction NN cord-329844-w969lczb 562 12 method method NN cord-329844-w969lczb 562 13 . . . cord-329844-w969lczb 563 1 The the DT cord-329844-w969lczb 563 2 molecular molecular JJ cord-329844-w969lczb 563 3 biology biology NN cord-329844-w969lczb 563 4 of of IN cord-329844-w969lczb 563 5 coronaviruses coronaviruse NNS cord-329844-w969lczb 563 6 Genomic Genomic NNP cord-329844-w969lczb 563 7 characterization characterization NN cord-329844-w969lczb 563 8 and and CC cord-329844-w969lczb 563 9 epidemiology epidemiology NN cord-329844-w969lczb 563 10 of of IN cord-329844-w969lczb 563 11 2019 2019 CD cord-329844-w969lczb 563 12 novel novel JJ cord-329844-w969lczb 563 13 coronavirus coronavirus NN cord-329844-w969lczb 563 14 : : : cord-329844-w969lczb 563 15 implications implication NNS cord-329844-w969lczb 563 16 for for IN cord-329844-w969lczb 563 17 virus virus NN cord-329844-w969lczb 563 18 origins origin NNS cord-329844-w969lczb 563 19 and and CC cord-329844-w969lczb 563 20 receptor receptor NN cord-329844-w969lczb 563 21 binding binding NN cord-329844-w969lczb 563 22 , , , cord-329844-w969lczb 563 23 www.thelancet www.thelancet NNP cord-329844-w969lczb 563 24 Preliminary Preliminary NNP cord-329844-w969lczb 563 25 Bioinformatics Bioinformatics NNP cord-329844-w969lczb 563 26 Studies Studies NNPS cord-329844-w969lczb 563 27 on on IN cord-329844-w969lczb 563 28 the the DT cord-329844-w969lczb 563 29 Design Design NNP cord-329844-w969lczb 563 30 of of IN cord-329844-w969lczb 563 31 Synthetic Synthetic NNP cord-329844-w969lczb 563 32 Vaccines Vaccines NNPS cord-329844-w969lczb 563 33 and and CC cord-329844-w969lczb 563 34 Preventative Preventative NNP cord-329844-w969lczb 563 35 Peptidomimetic Peptidomimetic NNP cord-329844-w969lczb 563 36 Antagonists Antagonists NNP cord-329844-w969lczb 563 37 against against IN cord-329844-w969lczb 563 38 the the DT cord-329844-w969lczb 563 39 Wuhan Wuhan NNP cord-329844-w969lczb 563 40 Seafood Seafood NNP cord-329844-w969lczb 563 41 Market Market NNP cord-329844-w969lczb 563 42 Coronavirus Coronavirus NNP cord-329844-w969lczb 563 43 . . . cord-329844-w969lczb 564 1 Possible possible JJ cord-329844-w969lczb 564 2 Importance importance NN cord-329844-w969lczb 564 3 of of IN cord-329844-w969lczb 564 4 the the DT cord-329844-w969lczb 564 5 KRSFIEDLLFNKV KRSFIEDLLFNKV NNP cord-329844-w969lczb 564 6 Motif Motif NNP cord-329844-w969lczb 564 7 Preliminary preliminary JJ cord-329844-w969lczb 564 8 bioinformatics bioinformatic NNS cord-329844-w969lczb 564 9 studies study NNS cord-329844-w969lczb 564 10 on on IN cord-329844-w969lczb 564 11 the the DT cord-329844-w969lczb 564 12 design design NN cord-329844-w969lczb 564 13 of of IN cord-329844-w969lczb 564 14 a a DT cord-329844-w969lczb 564 15 synthetic synthetic JJ cord-329844-w969lczb 564 16 vaccine vaccine NN cord-329844-w969lczb 564 17 and and CC cord-329844-w969lczb 564 18 a a DT cord-329844-w969lczb 564 19 preventative preventative JJ cord-329844-w969lczb 564 20 peptidomimetic peptidomimetic JJ cord-329844-w969lczb 564 21 antagonist antagonist NN cord-329844-w969lczb 564 22 against against IN cord-329844-w969lczb 564 23 the the DT cord-329844-w969lczb 564 24 SARS SARS NNP cord-329844-w969lczb 564 25 - - HYPH cord-329844-w969lczb 564 26 CoV-2 CoV-2 NNP cord-329844-w969lczb 565 1 ( ( -LRB- cord-329844-w969lczb 565 2 2019-nCoV 2019-ncov CD cord-329844-w969lczb 565 3 , , , cord-329844-w969lczb 565 4 COVID-19 COVID-19 NNP cord-329844-w969lczb 565 5 ) ) -RRB- cord-329844-w969lczb 565 6 coronavirus coronavirus NN cord-329844-w969lczb 565 7 COVID-19 COVID-19 NNP cord-329844-w969lczb 565 8 Coronavirus Coronavirus NNP cord-329844-w969lczb 565 9 Spike Spike NNP cord-329844-w969lczb 565 10 Protein Protein NNP cord-329844-w969lczb 565 11 Analysis Analysis NNP cord-329844-w969lczb 565 12 for for IN cord-329844-w969lczb 565 13 Synthetic synthetic JJ cord-329844-w969lczb 565 14 Vaccines Vaccines NNPS cord-329844-w969lczb 565 15 , , , cord-329844-w969lczb 565 16 a a DT cord-329844-w969lczb 565 17 Peptidomimetic Peptidomimetic NNP cord-329844-w969lczb 565 18 Antagonist Antagonist NNP cord-329844-w969lczb 565 19 , , , cord-329844-w969lczb 565 20 and and CC cord-329844-w969lczb 565 21 Therapeutic therapeutic JJ cord-329844-w969lczb 565 22 Drugs drug NNS cord-329844-w969lczb 565 23 , , , cord-329844-w969lczb 565 24 and and CC cord-329844-w969lczb 565 25 Analysis Analysis NNP cord-329844-w969lczb 565 26 of of IN cord-329844-w969lczb 565 27 a a DT cord-329844-w969lczb 565 28 Proposed propose VBN cord-329844-w969lczb 565 29 Achilles Achilles NNP cord-329844-w969lczb 565 30 ' ' '' cord-329844-w969lczb 565 31 Heel Heel NNP cord-329844-w969lczb 565 32 Conserved Conserved NNP cord-329844-w969lczb 565 33 Region Region NNP cord-329844-w969lczb 565 34 to to TO cord-329844-w969lczb 565 35 Minimize minimize VB cord-329844-w969lczb 565 36 Probability probability NN cord-329844-w969lczb 565 37 of of IN cord-329844-w969lczb 565 38 Escape Escape NNP cord-329844-w969lczb 565 39 Mutations Mutations NNPS cord-329844-w969lczb 565 40 and and CC cord-329844-w969lczb 565 41 Drug Drug NNP cord-329844-w969lczb 565 42 Resistance Resistance NNP cord-329844-w969lczb 566 1 The the DT cord-329844-w969lczb 566 2 spike spike NN cord-329844-w969lczb 566 3 glycoprotein glycoprotein NN cord-329844-w969lczb 566 4 of of IN cord-329844-w969lczb 566 5 the the DT cord-329844-w969lczb 566 6 new new JJ cord-329844-w969lczb 566 7 coronavirus coronavirus NN cord-329844-w969lczb 566 8 2019-nCoV 2019-ncov CD cord-329844-w969lczb 566 9 contains contain VBZ cord-329844-w969lczb 566 10 a a DT cord-329844-w969lczb 566 11 furin furin NN cord-329844-w969lczb 566 12 - - HYPH cord-329844-w969lczb 566 13 like like JJ cord-329844-w969lczb 566 14 cleavage cleavage NN cord-329844-w969lczb 566 15 site site NN cord-329844-w969lczb 566 16 absent absent JJ cord-329844-w969lczb 566 17 in in IN cord-329844-w969lczb 566 18 CoV cov NN cord-329844-w969lczb 566 19 of of IN cord-329844-w969lczb 566 20 the the DT cord-329844-w969lczb 566 21 same same JJ cord-329844-w969lczb 566 22 clade clade NN cord-329844-w969lczb 567 1 Neuraminidase Neuraminidase NNP cord-329844-w969lczb 567 2 Is be VBZ cord-329844-w969lczb 567 3 Important important JJ cord-329844-w969lczb 567 4 for for IN cord-329844-w969lczb 567 5 the the DT cord-329844-w969lczb 567 6 Initiation Initiation NNP cord-329844-w969lczb 567 7 of of IN cord-329844-w969lczb 567 8 Influenza Influenza NNP cord-329844-w969lczb 567 9 Virus Virus NNP cord-329844-w969lczb 567 10 Infection Infection NNP cord-329844-w969lczb 567 11 in in IN cord-329844-w969lczb 567 12 Human Human NNP cord-329844-w969lczb 567 13 Airway Airway NNP cord-329844-w969lczb 567 14 Epithelium epithelium NN cord-329844-w969lczb 568 1 The the DT cord-329844-w969lczb 568 2 E3 e3 NN cord-329844-w969lczb 568 3 protein protein NN cord-329844-w969lczb 568 4 of of IN cord-329844-w969lczb 568 5 bovine bovine JJ cord-329844-w969lczb 568 6 coronavirus coronavirus NN cord-329844-w969lczb 568 7 is be VBZ cord-329844-w969lczb 568 8 a a DT cord-329844-w969lczb 568 9 receptor receptor NN cord-329844-w969lczb 568 10 - - HYPH cord-329844-w969lczb 568 11 destroying destroy VBG cord-329844-w969lczb 568 12 enzyme enzyme NN cord-329844-w969lczb 568 13 with with IN cord-329844-w969lczb 568 14 acetylesterase acetylesterase NN cord-329844-w969lczb 568 15 activity activity NN cord-329844-w969lczb 568 16 Structure Structure NNP cord-329844-w969lczb 568 17 of of IN cord-329844-w969lczb 568 18 coronavirus coronavirus NN cord-329844-w969lczb 568 19 hemagglutinin hemagglutinin NN cord-329844-w969lczb 568 20 - - HYPH cord-329844-w969lczb 568 21 esterase esterase NN cord-329844-w969lczb 568 22 offers offer VBZ cord-329844-w969lczb 568 23 insight insight NN cord-329844-w969lczb 568 24 into into IN cord-329844-w969lczb 568 25 corona corona NN cord-329844-w969lczb 568 26 and and CC cord-329844-w969lczb 568 27 influenza influenza NN cord-329844-w969lczb 568 28 virus virus NN cord-329844-w969lczb 568 29 evolution evolution NN cord-329844-w969lczb 568 30 Overview Overview NNP cord-329844-w969lczb 568 31 of of IN cord-329844-w969lczb 568 32 Current Current NNP cord-329844-w969lczb 568 33 Therapeutics Therapeutics NNP cord-329844-w969lczb 568 34 and and CC cord-329844-w969lczb 568 35 Novel Novel NNP cord-329844-w969lczb 568 36 Candidates Candidates NNPS cord-329844-w969lczb 568 37 Against against IN cord-329844-w969lczb 568 38 Influenza Influenza NNP cord-329844-w969lczb 568 39 , , , cord-329844-w969lczb 568 40 Respiratory Respiratory NNP cord-329844-w969lczb 568 41 Syncytial Syncytial NNP cord-329844-w969lczb 568 42 Virus Virus NNP cord-329844-w969lczb 568 43 , , , cord-329844-w969lczb 568 44 and and CC cord-329844-w969lczb 569 1 Middle Middle NNP cord-329844-w969lczb 569 2 East East NNP cord-329844-w969lczb 569 3 Respiratory Respiratory NNP cord-329844-w969lczb 569 4 Syndrome Syndrome NNP cord-329844-w969lczb 569 5 Coronavirus Coronavirus NNP cord-329844-w969lczb 569 6 Infections Infections NNPS cord-329844-w969lczb 569 7 Drug Drug NNP cord-329844-w969lczb 569 8 treatment treatment NN cord-329844-w969lczb 569 9 options option NNS cord-329844-w969lczb 569 10 for for IN cord-329844-w969lczb 569 11 the the DT cord-329844-w969lczb 569 12 2019-new 2019-new CD cord-329844-w969lczb 569 13 coronavirus coronavirus NN cord-329844-w969lczb 569 14 ( ( -LRB- cord-329844-w969lczb 569 15 2019-nCoV 2019-ncov CD cord-329844-w969lczb 569 16 ) ) -RRB- cord-329844-w969lczb 569 17 Receptor receptor NN cord-329844-w969lczb 569 18 Recognition Recognition NNP cord-329844-w969lczb 569 19 Mechanisms Mechanisms NNPS cord-329844-w969lczb 569 20 of of IN cord-329844-w969lczb 569 21 Coronaviruses Coronaviruses NNPS cord-329844-w969lczb 569 22 : : : cord-329844-w969lczb 569 23 a a DT cord-329844-w969lczb 569 24 Decade decade NN cord-329844-w969lczb 569 25 of of IN cord-329844-w969lczb 569 26 Structural Structural NNP cord-329844-w969lczb 569 27 Studies Studies NNPS cord-329844-w969lczb 569 28 Journal Journal NNP cord-329844-w969lczb 569 29 of of IN cord-329844-w969lczb 569 30 Virology Virology NNP cord-329844-w969lczb 570 1 The the DT cord-329844-w969lczb 570 2 3D 3d JJ cord-329844-w969lczb 570 3 structure structure NN cord-329844-w969lczb 570 4 analysis analysis NN cord-329844-w969lczb 570 5 of of IN cord-329844-w969lczb 570 6 SARS SARS NNP cord-329844-w969lczb 570 7 - - HYPH cord-329844-w969lczb 570 8 CoV CoV NNP cord-329844-w969lczb 570 9 S1 S1 NNP cord-329844-w969lczb 570 10 protein protein NN cord-329844-w969lczb 570 11 reveals reveal VBZ cord-329844-w969lczb 570 12 a a DT cord-329844-w969lczb 570 13 link link NN cord-329844-w969lczb 570 14 to to IN cord-329844-w969lczb 570 15 influenza influenza NN cord-329844-w969lczb 570 16 virus virus NN cord-329844-w969lczb 570 17 neuraminidase neuraminidase NN cord-329844-w969lczb 570 18 and and CC cord-329844-w969lczb 570 19 implications implication NNS cord-329844-w969lczb 570 20 for for IN cord-329844-w969lczb 570 21 drug drug NN cord-329844-w969lczb 570 22 and and CC cord-329844-w969lczb 570 23 antibody antibody NN cord-329844-w969lczb 570 24 discovery discovery NN cord-329844-w969lczb 570 25 Tryptophan tryptophan NN cord-329844-w969lczb 570 26 residues residue NNS cord-329844-w969lczb 570 27 and and CC cord-329844-w969lczb 570 28 the the DT cord-329844-w969lczb 570 29 sugar sugar NN cord-329844-w969lczb 570 30 binding binding NN cord-329844-w969lczb 570 31 site site NN cord-329844-w969lczb 570 32 of of IN cord-329844-w969lczb 570 33 potato potato NN cord-329844-w969lczb 570 34 lectin lectin NN cord-329844-w969lczb 570 35 Inhibition Inhibition NNP cord-329844-w969lczb 570 36 of of IN cord-329844-w969lczb 570 37 SARS SARS NNP cord-329844-w969lczb 570 38 Coronavirus Coronavirus NNP cord-329844-w969lczb 570 39 Infection Infection NNP cord-329844-w969lczb 571 1 In in IN cord-329844-w969lczb 571 2 Vitro Vitro NNP cord-329844-w969lczb 571 3 with with IN cord-329844-w969lczb 571 4 Clinically clinically RB cord-329844-w969lczb 571 5 Approved approve VBN cord-329844-w969lczb 571 6 Antiviral antiviral JJ cord-329844-w969lczb 571 7 Drugs drug NNS cord-329844-w969lczb 572 1 Sialic Sialic NNP cord-329844-w969lczb 572 2 acids acid NNS cord-329844-w969lczb 572 3 as as IN cord-329844-w969lczb 572 4 receptor receptor NN cord-329844-w969lczb 572 5 determinants determinant NNS cord-329844-w969lczb 572 6 for for IN cord-329844-w969lczb 572 7 coronaviruses coronaviruse NNS cord-329844-w969lczb 573 1 Structural structural JJ cord-329844-w969lczb 573 2 and and CC cord-329844-w969lczb 573 3 molecular molecular JJ cord-329844-w969lczb 573 4 modelling modelling NN cord-329844-w969lczb 573 5 studies study NNS cord-329844-w969lczb 573 6 reveal reveal VBP cord-329844-w969lczb 573 7 a a DT cord-329844-w969lczb 573 8 new new JJ cord-329844-w969lczb 573 9 mechanism mechanism NN cord-329844-w969lczb 573 10 of of IN cord-329844-w969lczb 573 11 action action NN cord-329844-w969lczb 573 12 of of IN cord-329844-w969lczb 573 13 chloroquine chloroquine NNP cord-329844-w969lczb 573 14 and and CC cord-329844-w969lczb 573 15 hydroxychloroquine hydroxychloroquine NN cord-329844-w969lczb 573 16 against against IN cord-329844-w969lczb 573 17 SARS SARS NNP cord-329844-w969lczb 573 18 - - HYPH cord-329844-w969lczb 573 19 CoV-2 CoV-2 NNP cord-329844-w969lczb 573 20 infection infection NN cord-329844-w969lczb 573 21 Carbohydrate carbohydrate NN cord-329844-w969lczb 573 22 - - HYPH cord-329844-w969lczb 573 23 Binding Binding NNP cord-329844-w969lczb 573 24 Modules Modules NNPS cord-329844-w969lczb 573 25 Analysis Analysis NNP cord-329844-w969lczb 573 26 and and CC cord-329844-w969lczb 573 27 prediction prediction NN cord-329844-w969lczb 573 28 of of IN cord-329844-w969lczb 573 29 carbohydrate carbohydrate NN cord-329844-w969lczb 573 30 binding binding NN cord-329844-w969lczb 573 31 sites site NNS cord-329844-w969lczb 574 1 GOR GOR NNP cord-329844-w969lczb 574 2 method method NN cord-329844-w969lczb 574 3 for for IN cord-329844-w969lczb 574 4 predicting predict VBG cord-329844-w969lczb 574 5 protein protein NN cord-329844-w969lczb 574 6 secondary secondary JJ cord-329844-w969lczb 574 7 structure structure NN cord-329844-w969lczb 574 8 from from IN cord-329844-w969lczb 574 9 amino amino NN cord-329844-w969lczb 574 10 acid acid NN cord-329844-w969lczb 574 11 sequence sequence NN cord-329844-w969lczb 575 1 Hyperbolic hyperbolic JJ cord-329844-w969lczb 575 2 Dirac Dirac NNP cord-329844-w969lczb 575 3 Nets Nets NNPS cord-329844-w969lczb 575 4 for for IN cord-329844-w969lczb 575 5 Medical Medical NNP cord-329844-w969lczb 575 6 Decision Decision NNP cord-329844-w969lczb 575 7 Support Support NNP cord-329844-w969lczb 575 8 . . . cord-329844-w969lczb 576 1 Theory theory NN cord-329844-w969lczb 576 2 , , , cord-329844-w969lczb 576 3 Methods Methods NNPS cord-329844-w969lczb 576 4 , , , cord-329844-w969lczb 576 5 and and CC cord-329844-w969lczb 576 6 Comparison comparison NN cord-329844-w969lczb 576 7 with with IN cord-329844-w969lczb 576 8 Bayes Bayes NNP cord-329844-w969lczb 576 9 Nets Nets NNPS cord-329844-w969lczb 576 10 Split Split NNP cord-329844-w969lczb 576 11 - - HYPH cord-329844-w969lczb 576 12 Complex Complex NNP cord-329844-w969lczb 576 13 Numbers Numbers NNPS cord-329844-w969lczb 576 14 and and CC cord-329844-w969lczb 576 15 Dirac Dirac NNP cord-329844-w969lczb 576 16 Bra Bra NNP cord-329844-w969lczb 576 17 - - HYPH cord-329844-w969lczb 576 18 Kets Kets NNP cord-329844-w969lczb 576 19 Bidirectional Bidirectional NNP cord-329844-w969lczb 576 20 General General NNP cord-329844-w969lczb 576 21 Graphs Graphs NNP cord-329844-w969lczb 576 22 for for IN cord-329844-w969lczb 576 23 inference inference NN cord-329844-w969lczb 576 24 . . . cord-329844-w969lczb 577 1 Principles principle NNS cord-329844-w969lczb 577 2 and and CC cord-329844-w969lczb 577 3 implications implication NNS cord-329844-w969lczb 577 4 for for IN cord-329844-w969lczb 577 5 medicine medicine NN cord-329844-w969lczb 577 6 Suggestions suggestion NNS cord-329844-w969lczb 577 7 for for IN cord-329844-w969lczb 577 8 a a DT cord-329844-w969lczb 577 9 Web Web NNP cord-329844-w969lczb 577 10 Based Based NNP cord-329844-w969lczb 577 11 Universal Universal NNP cord-329844-w969lczb 577 12 Exchange Exchange NNP cord-329844-w969lczb 577 13 and and CC cord-329844-w969lczb 577 14 Inference Inference NNP cord-329844-w969lczb 577 15 Language Language NNP cord-329844-w969lczb 577 16 for for IN cord-329844-w969lczb 577 17 Medicine Medicine NNP cord-329844-w969lczb 577 18 Implementation Implementation NNP cord-329844-w969lczb 577 19 of of IN cord-329844-w969lczb 577 20 a a DT cord-329844-w969lczb 577 21 web web NN cord-329844-w969lczb 577 22 based base VBN cord-329844-w969lczb 577 23 universal universal JJ cord-329844-w969lczb 577 24 exchange exchange NN cord-329844-w969lczb 577 25 and and CC cord-329844-w969lczb 577 26 inference inference NN cord-329844-w969lczb 577 27 language language NN cord-329844-w969lczb 577 28 for for IN cord-329844-w969lczb 577 29 medicine medicine NN cord-329844-w969lczb 577 30 . . . cord-329844-w969lczb 578 1 Sparse sparse JJ cord-329844-w969lczb 578 2 data datum NNS cord-329844-w969lczb 578 3 , , , cord-329844-w969lczb 578 4 probabilities probability NNS cord-329844-w969lczb 578 5 and and CC cord-329844-w969lczb 578 6 inference inference NN cord-329844-w969lczb 578 7 in in IN cord-329844-w969lczb 578 8 data datum NNS cord-329844-w969lczb 578 9 mining mining NN cord-329844-w969lczb 578 10 of of IN cord-329844-w969lczb 578 11 clinical clinical JJ cord-329844-w969lczb 578 12 data datum NNS cord-329844-w969lczb 578 13 repositories repository NNS cord-329844-w969lczb 578 14 Studies Studies NNPS cord-329844-w969lczb 578 15 in in IN cord-329844-w969lczb 578 16 Using use VBG cord-329844-w969lczb 578 17 a a DT cord-329844-w969lczb 578 18 Universal Universal NNP cord-329844-w969lczb 578 19 Exchange Exchange NNP cord-329844-w969lczb 578 20 and and CC cord-329844-w969lczb 578 21 Inference Inference NNP cord-329844-w969lczb 578 22 Language Language NNP cord-329844-w969lczb 578 23 for for IN cord-329844-w969lczb 578 24 Evidence evidence NN cord-329844-w969lczb 578 25 Based Based NNP cord-329844-w969lczb 578 26 Medicine Medicine NNP cord-329844-w969lczb 578 27 . . . cord-329844-w969lczb 579 1 Semi semi JJ cord-329844-w969lczb 579 2 - - JJ cord-329844-w969lczb 579 3 Automated automated JJ cord-329844-w969lczb 579 4 Learning Learning NNP cord-329844-w969lczb 579 5 and and CC cord-329844-w969lczb 579 6 Reasoning reason VBG cord-329844-w969lczb 579 7 for for IN cord-329844-w969lczb 579 8 PICO PICO NNP cord-329844-w969lczb 579 9 Methodology Methodology NNP cord-329844-w969lczb 579 10 , , , cord-329844-w969lczb 579 11 Systematic Systematic NNP cord-329844-w969lczb 579 12 Review Review NNP cord-329844-w969lczb 579 13 , , , cord-329844-w969lczb 579 14 and and CC cord-329844-w969lczb 579 15 Environmental Environmental NNP cord-329844-w969lczb 579 16 Epidemiology Epidemiology NNP cord-329844-w969lczb 579 17 Studies Studies NNPS cord-329844-w969lczb 579 18 in in IN cord-329844-w969lczb 579 19 the the DT cord-329844-w969lczb 579 20 Extensively extensively RB cord-329844-w969lczb 579 21 Automatic Automatic NNP cord-329844-w969lczb 579 22 Construction Construction NNP cord-329844-w969lczb 579 23 of of IN cord-329844-w969lczb 579 24 Large Large NNP cord-329844-w969lczb 579 25 Odds Odds NNPS cord-329844-w969lczb 579 26 - - HYPH cord-329844-w969lczb 579 27 Based base VBN cord-329844-w969lczb 579 28 Inference Inference NNP cord-329844-w969lczb 579 29 Networks Networks NNP cord-329844-w969lczb 579 30 from from IN cord-329844-w969lczb 579 31 Structured Structured NNP cord-329844-w969lczb 579 32 Data Data NNP cord-329844-w969lczb 579 33 . . . cord-329844-w969lczb 580 1 Examples example NNS cord-329844-w969lczb 580 2 from from IN cord-329844-w969lczb 580 3 Medical Medical NNP cord-329844-w969lczb 580 4 , , , cord-329844-w969lczb 580 5 Bioinformatics Bioinformatics NNP cord-329844-w969lczb 580 6 , , , cord-329844-w969lczb 580 7 and and CC cord-329844-w969lczb 580 8 Health Health NNP cord-329844-w969lczb 580 9 Insurance Insurance NNP cord-329844-w969lczb 580 10 Claims Claims NNP cord-329844-w969lczb 580 11 Data Data NNP cord-329844-w969lczb 580 12 Extension Extension NNP cord-329844-w969lczb 580 13 of of IN cord-329844-w969lczb 580 14 the the DT cord-329844-w969lczb 580 15 Quantum Quantum NNP cord-329844-w969lczb 580 16 Universal Universal NNP cord-329844-w969lczb 580 17 Exchange Exchange NNP cord-329844-w969lczb 580 18 Language Language NNP cord-329844-w969lczb 580 19 to to IN cord-329844-w969lczb 580 20 precision precision NN cord-329844-w969lczb 580 21 medicine medicine NN cord-329844-w969lczb 580 22 and and CC cord-329844-w969lczb 580 23 drug drug NN cord-329844-w969lczb 580 24 lead lead NN cord-329844-w969lczb 580 25 discovery discovery NN cord-329844-w969lczb 580 26 . . . cord-329844-w969lczb 581 1 Preliminary preliminary JJ cord-329844-w969lczb 581 2 example example NN cord-329844-w969lczb 581 3 studies study NNS cord-329844-w969lczb 581 4 using use VBG cord-329844-w969lczb 581 5 the the DT cord-329844-w969lczb 581 6 mitochondrial mitochondrial JJ cord-329844-w969lczb 581 7 genome genome NN cord-329844-w969lczb 581 8 SARS SARS NNP cord-329844-w969lczb 581 9 - - HYPH cord-329844-w969lczb 581 10 CoV-2 CoV-2 NNP cord-329844-w969lczb 581 11 entry entry NN cord-329844-w969lczb 581 12 factors factor NNS cord-329844-w969lczb 581 13 are be VBP cord-329844-w969lczb 581 14 highly highly RB cord-329844-w969lczb 581 15 expressed express VBN cord-329844-w969lczb 581 16 in in IN cord-329844-w969lczb 581 17 nasal nasal JJ cord-329844-w969lczb 581 18 epithelial epithelial JJ cord-329844-w969lczb 581 19 cells cell NNS cord-329844-w969lczb 581 20 together together RB cord-329844-w969lczb 581 21 with with IN cord-329844-w969lczb 581 22 innate innate JJ cord-329844-w969lczb 581 23 immune immune JJ cord-329844-w969lczb 581 24 genes gene NNS cord-329844-w969lczb 582 1 In in IN cord-329844-w969lczb 582 2 - - HYPH cord-329844-w969lczb 582 3 Silico Silico NNP cord-329844-w969lczb 582 4 evidence evidence NN cord-329844-w969lczb 582 5 for for IN cord-329844-w969lczb 582 6 two two CD cord-329844-w969lczb 582 7 receptors receptor NNS cord-329844-w969lczb 582 8 based base VBN cord-329844-w969lczb 582 9 strategy strategy NN cord-329844-w969lczb 582 10 of of IN cord-329844-w969lczb 583 1 SARS SARS NNP cord-329844-w969lczb 583 2 - - HYPH cord-329844-w969lczb 583 3 CoV-2 CoV-2 NNP cord-329844-w969lczb 583 4 Barry Barry NNP cord-329844-w969lczb 583 5 was be VBD cord-329844-w969lczb 583 6 a a DT cord-329844-w969lczb 583 7 pioneer pioneer NN cord-329844-w969lczb 583 8 in in IN cord-329844-w969lczb 583 9 bioinformatics bioinformatic NNS cord-329844-w969lczb 583 10 , , , cord-329844-w969lczb 583 11 protein protein NN cord-329844-w969lczb 583 12 modelling modelling NN cord-329844-w969lczb 583 13 , , , cord-329844-w969lczb 583 14 and and CC cord-329844-w969lczb 583 15 computer computer NN cord-329844-w969lczb 583 16 - - HYPH cord-329844-w969lczb 583 17 aided aid VBN cord-329844-w969lczb 583 18 drug drug NN cord-329844-w969lczb 583 19 design design NN cord-329844-w969lczb 583 20 , , , cord-329844-w969lczb 583 21 interests interest NNS cord-329844-w969lczb 583 22 that that WDT cord-329844-w969lczb 583 23 he -PRON- PRP cord-329844-w969lczb 583 24 actively actively RB cord-329844-w969lczb 583 25 continues continue VBZ cord-329844-w969lczb 583 26 today today NN cord-329844-w969lczb 583 27 . . . cord-329844-w969lczb 584 1 He -PRON- PRP cord-329844-w969lczb 584 2 is be VBZ cord-329844-w969lczb 584 3 the the DT cord-329844-w969lczb 584 4 recipient recipient NN cord-329844-w969lczb 584 5 of of IN cord-329844-w969lczb 584 6 several several JJ cord-329844-w969lczb 584 7 honours honour NNS cord-329844-w969lczb 584 8 including include VBG cord-329844-w969lczb 584 9 the the DT cord-329844-w969lczb 584 10 Asklepios Asklepios NNP cord-329844-w969lczb 584 11 Award Award NNP cord-329844-w969lczb 584 12 for for IN cord-329844-w969lczb 584 13 Outstanding Outstanding NNP cord-329844-w969lczb 584 14 Vision Vision NNP cord-329844-w969lczb 584 15 in in IN cord-329844-w969lczb 584 16 Science Science NNP cord-329844-w969lczb 584 17 and and CC cord-329844-w969lczb 584 18 Technology Technology NNP cord-329844-w969lczb 584 19 at at IN cord-329844-w969lczb 584 20 the the DT cord-329844-w969lczb 584 21 Future Future NNP cord-329844-w969lczb 584 22 of of IN cord-329844-w969lczb 584 23 Health Health NNP cord-329844-w969lczb 584 24 Technology Technology NNP cord-329844-w969lczb 584 25 Congress Congress NNP cord-329844-w969lczb 584 26 at at IN cord-329844-w969lczb 584 27 M.I.T. M.I.T. NNP cord-329844-w969lczb 584 28 in in IN cord-329844-w969lczb 584 29 2002 2002 CD cord-329844-w969lczb 584 30 . . . cord-329844-w969lczb 585 1 He -PRON- PRP cord-329844-w969lczb 585 2 has have VBZ cord-329844-w969lczb 585 3 helped help VBN cord-329844-w969lczb 585 4 start start VB cord-329844-w969lczb 585 5 up up RP cord-329844-w969lczb 585 6 several several JJ cord-329844-w969lczb 585 7 other other JJ cord-329844-w969lczb 585 8 companies company NNS cord-329844-w969lczb 585 9 or or CC cord-329844-w969lczb 585 10 divisions division NNS cord-329844-w969lczb 585 11 in in IN cord-329844-w969lczb 585 12 the the DT cord-329844-w969lczb 585 13 UK UK NNP cord-329844-w969lczb 585 14 and and CC cord-329844-w969lczb 585 15 USA USA NNP cord-329844-w969lczb 585 16 . . . cord-329844-w969lczb 586 1 Barry Barry NNP cord-329844-w969lczb 586 2 continues continue VBZ cord-329844-w969lczb 586 3 as as IN cord-329844-w969lczb 586 4 CEO ceo NN cord-329844-w969lczb 586 5 of of IN cord-329844-w969lczb 586 6 The the DT cord-329844-w969lczb 586 7 Dirac Dirac NNP cord-329844-w969lczb 586 8 Foundation Foundation NNP cord-329844-w969lczb 586 9 in in IN cord-329844-w969lczb 586 10 the the DT cord-329844-w969lczb 586 11 UK UK NNP cord-329844-w969lczb 586 12 , , , cord-329844-w969lczb 586 13 and and CC cord-329844-w969lczb 586 14 Distinguished Distinguished NNP cord-329844-w969lczb 586 15 Scientist Scientist NNP cord-329844-w969lczb 586 16 Prior prior RB cord-329844-w969lczb 586 17 to to IN cord-329844-w969lczb 586 18 that that DT cord-329844-w969lczb 587 1 , , , cord-329844-w969lczb 587 2 he -PRON- PRP cord-329844-w969lczb 587 3 was be VBD cord-329844-w969lczb 587 4 CSO CSO NNP cord-329844-w969lczb 587 5 of of IN cord-329844-w969lczb 587 6 Gryphon Gryphon NNP cord-329844-w969lczb 587 7 Sciences Sciences NNPS cord-329844-w969lczb 587 8 ( ( -LRB- cord-329844-w969lczb 587 9 later later RB cord-329844-w969lczb 587 10 Gryphon Gryphon NNP cord-329844-w969lczb 587 11 Pharmaceuticals Pharmaceuticals NNPS cord-329844-w969lczb 587 12 ) ) -RRB- cord-329844-w969lczb 587 13 in in IN cord-329844-w969lczb 587 14 South South NNP cord-329844-w969lczb 587 15 San San NNP cord-329844-w969lczb 587 16 Francisco Francisco NNP cord-329844-w969lczb 587 17 , , , cord-329844-w969lczb 587 18 California California NNP cord-329844-w969lczb 587 19 , , , cord-329844-w969lczb 587 20 a a DT cord-329844-w969lczb 587 21 bio bio JJ cord-329844-w969lczb 587 22 - - JJ cord-329844-w969lczb 587 23 nanotechnology nanotechnology JJ cord-329844-w969lczb 587 24 ultrastructural ultrastructural JJ cord-329844-w969lczb 587 25 chemistry chemistry NN cord-329844-w969lczb 587 26 start start NN cord-329844-w969lczb 587 27 - - HYPH cord-329844-w969lczb 587 28 up up NN cord-329844-w969lczb 587 29 largely largely RB cord-329844-w969lczb 587 30 held hold VBN cord-329844-w969lczb 587 31 and and CC cord-329844-w969lczb 587 32 then then RB cord-329844-w969lczb 587 33 acquired acquire VBN cord-329844-w969lczb 587 34 by by IN cord-329844-w969lczb 587 35 SmithKline SmithKline NNP cord-329844-w969lczb 587 36 Beecham Beecham NNP cord-329844-w969lczb 587 37 . . . cord-329844-w969lczb 588 1 Before before IN cord-329844-w969lczb 588 2 moving move VBG cord-329844-w969lczb 588 3 to to IN cord-329844-w969lczb 588 4 the the DT cord-329844-w969lczb 588 5 US US NNP cord-329844-w969lczb 588 6 , , , cord-329844-w969lczb 588 7 Barry Barry NNP cord-329844-w969lczb 588 8 was be VBD cord-329844-w969lczb 588 9 the the DT cord-329844-w969lczb 588 10 scientific scientific JJ cord-329844-w969lczb 588 11 founder founder NN cord-329844-w969lczb 588 12 of of IN cord-329844-w969lczb 588 13 Proteus Proteus NNP cord-329844-w969lczb 588 14 International International NNP cord-329844-w969lczb 588 15 plc plc NNP cord-329844-w969lczb 588 16 in in IN cord-329844-w969lczb 588 17 the the DT cord-329844-w969lczb 588 18 UK UK NNP cord-329844-w969lczb 588 19 , , , cord-329844-w969lczb 588 20 designing design VBG cord-329844-w969lczb 588 21 and and CC cord-329844-w969lczb 588 22 leading lead VBG cord-329844-w969lczb 588 23 the the DT cord-329844-w969lczb 588 24 development development NN cord-329844-w969lczb 588 25 of of IN cord-329844-w969lczb 588 26 the the DT cord-329844-w969lczb 588 27 PROMETHEUS PROMETHEUS NNP cord-329844-w969lczb 588 28 Expert Expert NNP cord-329844-w969lczb 588 29 System System NNP cord-329844-w969lczb 588 30 and and CC cord-329844-w969lczb 588 31 its -PRON- PRP$ cord-329844-w969lczb 588 32 underlying underlying JJ cord-329844-w969lczb 588 33 GLOBAL GLOBAL NNP cord-329844-w969lczb 588 34 Expert Expert NNP cord-329844-w969lczb 588 35 System System NNP cord-329844-w969lczb 588 36 , , , cord-329844-w969lczb 588 37 bioinformatics bioinformatic NNS cord-329844-w969lczb 588 38 and and CC cord-329844-w969lczb 588 39 simulation simulation NN cord-329844-w969lczb 588 40 language language NN cord-329844-w969lczb 588 41 for for IN cord-329844-w969lczb 588 42 drug drug NN cord-329844-w969lczb 588 43 , , , cord-329844-w969lczb 588 44 vaccine vaccine NN cord-329844-w969lczb 588 45 , , , cord-329844-w969lczb 588 46 and and CC cord-329844-w969lczb 588 47 diagnostic diagnostic JJ cord-329844-w969lczb 588 48 discovery discovery NN cord-329844-w969lczb 588 49 . . . cord-329844-w969lczb 589 1 It -PRON- PRP cord-329844-w969lczb 589 2 sold sell VBD cord-329844-w969lczb 589 3 for for IN cord-329844-w969lczb 589 4 the the DT cord-329844-w969lczb 589 5 equivalent equivalent NN cord-329844-w969lczb 589 6 of of IN cord-329844-w969lczb 589 7 $ $ $ cord-329844-w969lczb 589 8 9.4 9.4 CD cord-329844-w969lczb 589 9 million million CD cord-329844-w969lczb 589 10 to to IN cord-329844-w969lczb 589 11 the the DT cord-329844-w969lczb 589 12 pharmaceutical pharmaceutical JJ cord-329844-w969lczb 589 13 industry industry NN cord-329844-w969lczb 589 14 in in IN cord-329844-w969lczb 589 15 the the DT cord-329844-w969lczb 589 16 mid-1990s mid-1990 NNS cord-329844-w969lczb 589 17 . . . cord-329844-w969lczb 590 1 At at IN cord-329844-w969lczb 590 2 Proteus Proteus NNP cord-329844-w969lczb 590 3 , , , cord-329844-w969lczb 590 4 he -PRON- PRP cord-329844-w969lczb 590 5 also also RB cord-329844-w969lczb 590 6 led lead VBD cord-329844-w969lczb 590 7 the the DT cord-329844-w969lczb 590 8 team team NN cord-329844-w969lczb 590 9 that that WDT cord-329844-w969lczb 590 10 used use VBD cord-329844-w969lczb 590 11 the the DT cord-329844-w969lczb 590 12 above above JJ cord-329844-w969lczb 590 13 Expert Expert NNP cord-329844-w969lczb 590 14 System System NNP cord-329844-w969lczb 590 15 to to TO cord-329844-w969lczb 590 16 invent invent VB cord-329844-w969lczb 590 17 and and CC cord-329844-w969lczb 590 18 patent patent VB cord-329844-w969lczb 590 19 several several JJ cord-329844-w969lczb 590 20 diagnostics diagnostic NNS cord-329844-w969lczb 590 21 and and CC cord-329844-w969lczb 590 22 vaccines vaccine NNS cord-329844-w969lczb 590 23 including include VBG cord-329844-w969lczb 590 24 the the DT cord-329844-w969lczb 590 25 Mad mad JJ cord-329844-w969lczb 590 26 Cow cow NN cord-329844-w969lczb 590 27 disease disease NN cord-329844-w969lczb 590 28 diagnostic diagnostic JJ cord-329844-w969lczb 590 29 subsequently subsequently RB cord-329844-w969lczb 590 30 marketed market VBN cord-329844-w969lczb 590 31 worldwide worldwide RB cord-329844-w969lczb 590 32 by by IN cord-329844-w969lczb 590 33 Abbott Abbott NNP cord-329844-w969lczb 590 34 as as IN cord-329844-w969lczb 590 35 a a DT cord-329844-w969lczb 590 36 whitepaper whitepaper NN cord-329844-w969lczb 590 37 to to IN cord-329844-w969lczb 590 38 the the DT cord-329844-w969lczb 590 39 President President NNP cord-329844-w969lczb 590 40 of of IN cord-329844-w969lczb 590 41 the the DT cord-329844-w969lczb 590 42 United United NNP cord-329844-w969lczb 590 43 States States NNP cord-329844-w969lczb 590 44 . . . cord-329844-w969lczb 591 1 He -PRON- PRP cord-329844-w969lczb 591 2 was be VBD cord-329844-w969lczb 591 3 also also RB cord-329844-w969lczb 591 4 an an DT cord-329844-w969lczb 591 5 advisor advisor NN cord-329844-w969lczb 591 6 in in IN cord-329844-w969lczb 591 7 relation relation NN cord-329844-w969lczb 591 8 to to IN cord-329844-w969lczb 591 9 a a DT cord-329844-w969lczb 591 10 major major JJ cord-329844-w969lczb 591 11 scientific scientific JJ cord-329844-w969lczb 591 12 computer computer NN cord-329844-w969lczb 591 13 - - HYPH cord-329844-w969lczb 591 14 aided aid VBN cord-329844-w969lczb 591 15 drug drug NN cord-329844-w969lczb 591 16 design design NN cord-329844-w969lczb 591 17 collaboration collaboration NN cord-329844-w969lczb 591 18 and and CC cord-329844-w969lczb 591 19 network network NN cord-329844-w969lczb 591 20 for for IN cord-329844-w969lczb 591 21 Peter Peter NNP cord-329844-w969lczb 591 22 Feinstein Feinstein NNP cord-329844-w969lczb 591 23 Consultants Consultants NNP cord-329844-w969lczb 591 24 between between IN cord-329844-w969lczb 591 25 work work NN cord-329844-w969lczb 591 26 between between IN cord-329844-w969lczb 591 27 US US NNP cord-329844-w969lczb 591 28 scientists scientist NNS cord-329844-w969lczb 591 29 and and CC cord-329844-w969lczb 591 30 the the DT cord-329844-w969lczb 591 31 Russian russian JJ cord-329844-w969lczb 591 32 Science Science NNP cord-329844-w969lczb 591 33 City City NNP cord-329844-w969lczb 591 34 Arzamas Arzamas NNP cord-329844-w969lczb 591 35 . . . cord-329844-w969lczb 592 1 For for IN cord-329844-w969lczb 592 2 five five CD cord-329844-w969lczb 592 3 years year NNS cord-329844-w969lczb 592 4 , , , cord-329844-w969lczb 592 5 Barry Barry NNP cord-329844-w969lczb 592 6 was be VBD cord-329844-w969lczb 592 7 a a DT cord-329844-w969lczb 592 8 Nature Nature NNP cord-329844-w969lczb 592 9 " " '' cord-329844-w969lczb 592 10 News News NNP cord-329844-w969lczb 592 11 and and CC cord-329844-w969lczb 592 12 Views Views NNPS cord-329844-w969lczb 592 13 " " '' cord-329844-w969lczb 592 14 Correspondent correspondent NN cord-329844-w969lczb 592 15 on on IN cord-329844-w969lczb 592 16 biomolecules biomolecule NNS cord-329844-w969lczb 592 17 . . . cord-329844-w969lczb 593 1 He -PRON- PRP cord-329844-w969lczb 593 2 was be VBD cord-329844-w969lczb 593 3 Visiting visit VBG cord-329844-w969lczb 593 4 Scholar Scholar NNP cord-329844-w969lczb 593 5 Stanford Stanford NNP cord-329844-w969lczb 593 6 University University NNP cord-329844-w969lczb 593 7 School School NNP cord-329844-w969lczb 593 8 of of IN cord-329844-w969lczb 593 9 Medicine Medicine NNP cord-329844-w969lczb 593 10 1997 1997 CD cord-329844-w969lczb 593 11 - - SYM cord-329844-w969lczb 593 12 1998 1998 CD cord-329844-w969lczb 593 13 , , , cord-329844-w969lczb 593 14 Professorial Professorial NNP cord-329844-w969lczb 593 15 Lecturer Lecturer NNP cord-329844-w969lczb 593 16 Mount Mount NNP cord-329844-w969lczb 593 17 Sinai Sinai NNP cord-329844-w969lczb 593 18 NYC NYC NNP cord-329844-w969lczb 593 19 during during IN cord-329844-w969lczb 593 20 part part NN cord-329844-w969lczb 593 21 of of IN cord-329844-w969lczb 593 22 his -PRON- PRP$ cord-329844-w969lczb 593 23 period period NN cord-329844-w969lczb 593 24 at at IN cord-329844-w969lczb 593 25 IBM IBM NNP cord-329844-w969lczb 593 26 Corporation Corporation NNP cord-329844-w969lczb 593 27 , , , cord-329844-w969lczb 593 28 and and CC cord-329844-w969lczb 593 29 held hold VBD cord-329844-w969lczb 593 30 visiting visit VBG cord-329844-w969lczb 593 31 positions position NNS cord-329844-w969lczb 593 32 and and CC cord-329844-w969lczb 593 33 professorships professorship NNS cord-329844-w969lczb 593 34 in in IN cord-329844-w969lczb 593 35 INRA INRA NNP cord-329844-w969lczb 593 36 and and CC cord-329844-w969lczb 593 37 U U NNP cord-329844-w969lczb 593 38 Quantum Quantum NNP cord-329844-w969lczb 593 39 Universal Universal NNP cord-329844-w969lczb 593 40 Exchange Exchange NNP cord-329844-w969lczb 593 41 Language Language NNP cord-329844-w969lczb 593 42 and and CC cord-329844-w969lczb 593 43 Hyperbolic Hyperbolic NNP cord-329844-w969lczb 593 44 Dirac Dirac NNP cord-329844-w969lczb 593 45 Nets Nets NNPS cord-329844-w969lczb 593 46 for for IN cord-329844-w969lczb 593 47 Precision Precision NNP cord-329844-w969lczb 593 48 Medicine Medicine NNP cord-329844-w969lczb 593 49 and and CC cord-329844-w969lczb 593 50 Drug Drug NNP cord-329844-w969lczb 593 51 Design Design NNP cord-329844-w969lczb 593 52 . . . cord-329844-w969lczb 594 1 Proposals proposal NNS cord-329844-w969lczb 594 2 with with IN cord-329844-w969lczb 594 3 Examples example NNS cord-329844-w969lczb 594 4 from from IN cord-329844-w969lczb 594 5 Mitochondrial Mitochondrial NNP cord-329844-w969lczb 594 6 Studies Studies NNP cord-329844-w969lczb 594 7 Studies Studies NNPS cord-329844-w969lczb 594 8 in in IN cord-329844-w969lczb 594 9 the the DT cord-329844-w969lczb 594 10 use use NN cord-329844-w969lczb 594 11 of of IN cord-329844-w969lczb 594 12 data datum NNS cord-329844-w969lczb 594 13 mining mining NN cord-329844-w969lczb 594 14 , , , cord-329844-w969lczb 594 15 prediction prediction NN cord-329844-w969lczb 594 16 algorithms algorithm NNS cord-329844-w969lczb 594 17 , , , cord-329844-w969lczb 594 18 and and CC cord-329844-w969lczb 594 19 a a DT cord-329844-w969lczb 594 20 universal universal JJ cord-329844-w969lczb 594 21 exchange exchange NN cord-329844-w969lczb 594 22 and and CC cord-329844-w969lczb 594 23 inference inference NN cord-329844-w969lczb 594 24 language language NN cord-329844-w969lczb 594 25 in in IN cord-329844-w969lczb 594 26 the the DT cord-329844-w969lczb 594 27 analysis analysis NN cord-329844-w969lczb 594 28 of of IN cord-329844-w969lczb 594 29 socioeconomic socioeconomic JJ cord-329844-w969lczb 594 30 health health NN cord-329844-w969lczb 594 31 data datum NNS cord-329844-w969lczb 594 32 Bidirectional Bidirectional NNP cord-329844-w969lczb 594 33 General General NNP cord-329844-w969lczb 594 34 Graphs Graphs NNP cord-329844-w969lczb 594 35 for for IN cord-329844-w969lczb 594 36 inference inference NN cord-329844-w969lczb 594 37 . . . cord-329844-w969lczb 595 1 Principles principle NNS cord-329844-w969lczb 595 2 and and CC cord-329844-w969lczb 595 3 implications implication NNS cord-329844-w969lczb 595 4 for for IN cord-329844-w969lczb 595 5 medicine medicine NN cord-329844-w969lczb 595 6 Studies Studies NNPS cord-329844-w969lczb 595 7 in in IN cord-329844-w969lczb 595 8 the the DT cord-329844-w969lczb 595 9 Extensively extensively RB cord-329844-w969lczb 595 10 Automatic Automatic NNP cord-329844-w969lczb 595 11 Construction Construction NNP cord-329844-w969lczb 595 12 of of IN cord-329844-w969lczb 595 13 Large Large NNP cord-329844-w969lczb 595 14 Odds Odds NNPS cord-329844-w969lczb 595 15 - - HYPH cord-329844-w969lczb 595 16 Based base VBN cord-329844-w969lczb 595 17 Inference Inference NNP cord-329844-w969lczb 595 18 Networks Networks NNP cord-329844-w969lczb 595 19 from from IN cord-329844-w969lczb 595 20 Structured Structured NNP cord-329844-w969lczb 595 21 Data Data NNP cord-329844-w969lczb 595 22 . . . cord-329844-w969lczb 596 1 Examples example NNS cord-329844-w969lczb 596 2 from from IN cord-329844-w969lczb 596 3 Medical Medical NNP cord-329844-w969lczb 596 4 , , , cord-329844-w969lczb 596 5 Bioinformatics Bioinformatics NNP cord-329844-w969lczb 596 6 , , , cord-329844-w969lczb 596 7 and and CC cord-329844-w969lczb 596 8 Health Health NNP cord-329844-w969lczb 596 9 Insurance Insurance NNP cord-329844-w969lczb 596 10 Claims Claims NNP cord-329844-w969lczb 596 11 Data Data NNP cord-329844-w969lczb 596 12 Studies Studies NNPS cord-329844-w969lczb 596 13 in in IN cord-329844-w969lczb 596 14 Using use VBG cord-329844-w969lczb 596 15 a a DT cord-329844-w969lczb 596 16 Universal Universal NNP cord-329844-w969lczb 596 17 Exchange Exchange NNP cord-329844-w969lczb 596 18 and and CC cord-329844-w969lczb 596 19 Inference Inference NNP cord-329844-w969lczb 596 20 Language Language NNP cord-329844-w969lczb 596 21 for for IN cord-329844-w969lczb 596 22 Evidence evidence NN cord-329844-w969lczb 596 23 Based Based NNP cord-329844-w969lczb 596 24 Medicine Medicine NNP cord-329844-w969lczb 596 25 . . . cord-329844-w969lczb 597 1 Semi semi JJ cord-329844-w969lczb 597 2 - - JJ cord-329844-w969lczb 597 3 Automated automated JJ cord-329844-w969lczb 597 4 Learning Learning NNP cord-329844-w969lczb 597 5 and and CC cord-329844-w969lczb 597 6 Reasoning reason VBG cord-329844-w969lczb 597 7 for for IN cord-329844-w969lczb 597 8 PICO PICO NNP cord-329844-w969lczb 597 9 Methodology Methodology NNP cord-329844-w969lczb 597 10 , , , cord-329844-w969lczb 597 11 Systematic Systematic NNP cord-329844-w969lczb 597 12 Review Review NNP cord-329844-w969lczb 597 13 , , , cord-329844-w969lczb 597 14 and and CC cord-329844-w969lczb 597 15 Environmental Environmental NNP cord-329844-w969lczb 597 16 Epidemiology Epidemiology NNP cord-329844-w969lczb 597 17 Studies Studies NNPS cord-329844-w969lczb 597 18 of of IN cord-329844-w969lczb 597 19 the the DT cord-329844-w969lczb 597 20 Role role NN cord-329844-w969lczb 597 21 of of IN cord-329844-w969lczb 597 22 a a DT cord-329844-w969lczb 597 23 Smart Smart NNP cord-329844-w969lczb 597 24 Web web NN cord-329844-w969lczb 597 25 for for IN cord-329844-w969lczb 597 26 Precision Precision NNP cord-329844-w969lczb 597 27 Medicine Medicine NNP cord-329844-w969lczb 597 28 Supported support VBN cord-329844-w969lczb 597 29 by by IN cord-329844-w969lczb 597 30 Biobanking Biobanking NNP cord-329844-w969lczb 597 31 Data Data NNP cord-329844-w969lczb 597 32 - - HYPH cord-329844-w969lczb 597 33 Mining Mining NNP cord-329844-w969lczb 597 34 to to TO cord-329844-w969lczb 597 35 Build build VB cord-329844-w969lczb 597 36 a a DT cord-329844-w969lczb 597 37 Knowledge Knowledge NNP cord-329844-w969lczb 597 38 Representation Representation NNP cord-329844-w969lczb 597 39 Store Store NNP cord-329844-w969lczb 597 40 for for IN cord-329844-w969lczb 597 41 Clinical Clinical NNP cord-329844-w969lczb 597 42 Decision Decision NNP cord-329844-w969lczb 597 43 Support Support NNP cord-329844-w969lczb 597 44 . . . cord-329844-w969lczb 598 1 Studies study NNS cord-329844-w969lczb 598 2 on on IN cord-329844-w969lczb 598 3 Curation Curation NNP cord-329844-w969lczb 598 4 and and CC cord-329844-w969lczb 598 5 Validation Validation NNP cord-329844-w969lczb 598 6 based base VBN cord-329844-w969lczb 598 7 on on IN cord-329844-w969lczb 598 8 Machine Machine NNP cord-329844-w969lczb 598 9 Performance Performance NNP cord-329844-w969lczb 598 10 in in IN cord-329844-w969lczb 598 11 Multiple Multiple NNP cord-329844-w969lczb 598 12 Choice Choice NNP cord-329844-w969lczb 598 13 Medical medical JJ cord-329844-w969lczb 598 14 Licensing licensing NN cord-329844-w969lczb 598 15 Examinations examination NNS cord-329844-w969lczb 599 1 Interesting interesting JJ cord-329844-w969lczb 599 2 things thing NNS cord-329844-w969lczb 599 3 for for IN cord-329844-w969lczb 599 4 computer computer NN cord-329844-w969lczb 599 5 systems system NNS cord-329844-w969lczb 599 6 to to TO cord-329844-w969lczb 599 7 do do VB cord-329844-w969lczb 599 8 : : : cord-329844-w969lczb 599 9 Keeping keeping NN cord-329844-w969lczb 599 10 and and CC cord-329844-w969lczb 599 11 data data NN cord-329844-w969lczb 599 12 mining mining NN cord-329844-w969lczb 599 13 millions million NNS cord-329844-w969lczb 599 14 of of IN cord-329844-w969lczb 599 15 patient patient JJ cord-329844-w969lczb 599 16 records record NNS cord-329844-w969lczb 599 17 , , , cord-329844-w969lczb 599 18 guiding guide VBG cord-329844-w969lczb 599 19 patients patient NNS cord-329844-w969lczb 599 20 and and CC cord-329844-w969lczb 599 21 physicians physician NNS cord-329844-w969lczb 599 22 , , , cord-329844-w969lczb 599 23 and and CC cord-329844-w969lczb 599 24 passing pass VBG cord-329844-w969lczb 599 25 medical medical JJ cord-329844-w969lczb 599 26 licensing licensing NN cord-329844-w969lczb 599 27 exams exam NNS cord-329844-w969lczb 599 28 Implementation implementation NN cord-329844-w969lczb 599 29 of of IN cord-329844-w969lczb 599 30 a a DT cord-329844-w969lczb 599 31 web web NN cord-329844-w969lczb 599 32 based base VBN cord-329844-w969lczb 599 33 universal universal JJ cord-329844-w969lczb 599 34 exchange exchange NN cord-329844-w969lczb 599 35 and and CC cord-329844-w969lczb 599 36 inference inference NN cord-329844-w969lczb 599 37 language language NN cord-329844-w969lczb 599 38 for for IN cord-329844-w969lczb 599 39 medicine medicine NN cord-329844-w969lczb 599 40 . . . cord-329844-w969lczb 600 1 Sparse sparse JJ cord-329844-w969lczb 600 2 data datum NNS cord-329844-w969lczb 600 3 , , , cord-329844-w969lczb 600 4 probabilities probability NNS cord-329844-w969lczb 600 5 and and CC cord-329844-w969lczb 600 6 inference inference NN cord-329844-w969lczb 600 7 in in IN cord-329844-w969lczb 600 8 data datum NNS cord-329844-w969lczb 600 9 mining mining NN cord-329844-w969lczb 600 10 of of IN cord-329844-w969lczb 600 11 clinical clinical JJ cord-329844-w969lczb 600 12 data data NN cord-329844-w969lczb 600 13 repositories repository NNS cord-329844-w969lczb 600 14 Split Split NNP cord-329844-w969lczb 600 15 - - HYPH cord-329844-w969lczb 600 16 Complex Complex NNP cord-329844-w969lczb 600 17 Numbers Numbers NNPS cord-329844-w969lczb 600 18 and and CC cord-329844-w969lczb 600 19 Dirac Dirac NNP cord-329844-w969lczb 600 20 Bra Bra NNP cord-329844-w969lczb 600 21 - - HYPH cord-329844-w969lczb 600 22 Kets Kets NNP cord-329844-w969lczb 600 23 Suggestions suggestion NNS cord-329844-w969lczb 600 24 for for IN cord-329844-w969lczb 600 25 a a DT cord-329844-w969lczb 600 26 Web Web NNP cord-329844-w969lczb 600 27 Based Based NNP cord-329844-w969lczb 600 28 Universal Universal NNP cord-329844-w969lczb 600 29 Exchange Exchange NNP cord-329844-w969lczb 600 30 and and CC cord-329844-w969lczb 600 31 Inference Inference NNP cord-329844-w969lczb 600 32 Language Language NNP cord-329844-w969lczb 600 33 for for IN cord-329844-w969lczb 600 34 Medicine Medicine NNP cord-329844-w969lczb 600 35 . . . cord-329844-w969lczb 601 1 Continuity continuity NN cord-329844-w969lczb 601 2 of of IN cord-329844-w969lczb 601 3 Patient Patient NNP cord-329844-w969lczb 601 4 Care Care NNP cord-329844-w969lczb 601 5 with with IN cord-329844-w969lczb 601 6 PCAST PCAST NNP cord-329844-w969lczb 601 7 Disaggregation Disaggregation NNP cord-329844-w969lczb 601 8 POPPER POPPER NNP cord-329844-w969lczb 601 9 , , , cord-329844-w969lczb 601 10 a a DT cord-329844-w969lczb 601 11 Simple Simple NNP cord-329844-w969lczb 601 12 Programming Programming NNP cord-329844-w969lczb 601 13 Language Language NNP cord-329844-w969lczb 601 14 for for IN cord-329844-w969lczb 601 15 Probabilistic Probabilistic NNP cord-329844-w969lczb 601 16 Semantic Semantic NNP cord-329844-w969lczb 601 17 Inference Inference NNP cord-329844-w969lczb 601 18 in in IN cord-329844-w969lczb 601 19 Medicine Medicine NNP cord-329844-w969lczb 602 1 Hyperbolic hyperbolic JJ cord-329844-w969lczb 602 2 Dirac Dirac NNP cord-329844-w969lczb 602 3 Nets Nets NNPS cord-329844-w969lczb 602 4 for for IN cord-329844-w969lczb 602 5 Medical Medical NNP cord-329844-w969lczb 602 6 Decision Decision NNP cord-329844-w969lczb 602 7 Support Support NNP cord-329844-w969lczb 602 8 . . . cord-329844-w969lczb 603 1 Theory theory NN cord-329844-w969lczb 603 2 , , , cord-329844-w969lczb 603 3 Methods Methods NNPS cord-329844-w969lczb 603 4 , , , cord-329844-w969lczb 603 5 and and CC cord-329844-w969lczb 603 6 Comparison comparison NN cord-329844-w969lczb 603 7 with with IN cord-329844-w969lczb 603 8 Bayes Bayes NNP cord-329844-w969lczb 603 9 Nets Nets NNPS cord-329844-w969lczb 603 10 Suggestions Suggestions NNPS cord-329844-w969lczb 603 11 for for IN cord-329844-w969lczb 603 12 a a DT cord-329844-w969lczb 603 13 Web Web NNP cord-329844-w969lczb 603 14 Based Based NNP cord-329844-w969lczb 603 15 Universal Universal NNP cord-329844-w969lczb 603 16 Exchange Exchange NNP cord-329844-w969lczb 603 17 and and CC cord-329844-w969lczb 603 18 Inference Inference NNP cord-329844-w969lczb 603 19 Language Language NNP cord-329844-w969lczb 603 20 for for IN cord-329844-w969lczb 603 21 Medicine Medicine NNP cord-329844-w969lczb 604 1 The the DT cord-329844-w969lczb 604 2 Concept Concept NNP cord-329844-w969lczb 604 3 of of IN cord-329844-w969lczb 604 4 Novel Novel NNP cord-329844-w969lczb 604 5 Compositions Compositions NNPS cord-329844-w969lczb 604 6 of of IN cord-329844-w969lczb 604 7 Matter Matter NNP cord-329844-w969lczb 604 8 . . . cord-329844-w969lczb 605 1 A a DT cord-329844-w969lczb 605 2 Theoretical theoretical JJ cord-329844-w969lczb 605 3 Analysis Analysis NNP cord-329844-w969lczb 605 4 Towards towards IN cord-329844-w969lczb 605 5 New New NNP cord-329844-w969lczb 605 6 Tools Tools NNPS cord-329844-w969lczb 605 7 for for IN cord-329844-w969lczb 605 8 Pharmacoepidemiology Pharmacoepidemiology NNP cord-329844-w969lczb 606 1 The the DT cord-329844-w969lczb 606 2 Role role NN cord-329844-w969lczb 606 3 of of IN cord-329844-w969lczb 606 4 Information Information NNP cord-329844-w969lczb 606 5 Drug Drug NNP cord-329844-w969lczb 606 6 discovery discovery NN cord-329844-w969lczb 606 7 using use VBG cord-329844-w969lczb 606 8 very very RB cord-329844-w969lczb 606 9 large large JJ cord-329844-w969lczb 606 10 numbers number NNS cord-329844-w969lczb 606 11 of of IN cord-329844-w969lczb 606 12 patents patent NNS cord-329844-w969lczb 606 13 . . . cord-329844-w969lczb 607 1 General general JJ cord-329844-w969lczb 607 2 strategy strategy NN cord-329844-w969lczb 607 3 with with IN cord-329844-w969lczb 607 4 extensive extensive JJ cord-329844-w969lczb 607 5 use use NN cord-329844-w969lczb 607 6 of of IN cord-329844-w969lczb 607 7 match match NN cord-329844-w969lczb 607 8 and and CC cord-329844-w969lczb 607 9 edit edit VB cord-329844-w969lczb 607 10 operations operation NNS cord-329844-w969lczb 607 11 Considerations consideration NNS cord-329844-w969lczb 607 12 , , , cord-329844-w969lczb 607 13 for for IN cord-329844-w969lczb 607 14 a a DT cord-329844-w969lczb 607 15 Universal Universal NNP cord-329844-w969lczb 607 16 Exchange Exchange NNP cord-329844-w969lczb 607 17 Language Language NNP cord-329844-w969lczb 607 18 for for IN cord-329844-w969lczb 607 19 Healthcare Healthcare NNP cord-329844-w969lczb 607 20 Quantum Quantum NNP cord-329844-w969lczb 607 21 Mechanics Mechanics NNPS cord-329844-w969lczb 607 22 in in IN cord-329844-w969lczb 607 23 Artificial Artificial NNP cord-329844-w969lczb 607 24 Intelligence Intelligence NNP cord-329844-w969lczb 607 25 and and CC cord-329844-w969lczb 607 26 Decision Decision NNP cord-329844-w969lczb 607 27 Support Support NNP cord-329844-w969lczb 607 28 . . . cord-329844-w969lczb 608 1 A a DT cord-329844-w969lczb 608 2 Review Review NNP cord-329844-w969lczb 609 1 This this DT cord-329844-w969lczb 609 2 project project NN cord-329844-w969lczb 609 3 used use VBD cord-329844-w969lczb 609 4 some some DT cord-329844-w969lczb 609 5 of of IN cord-329844-w969lczb 609 6 the the DT cord-329844-w969lczb 609 7 knowledge knowledge NN cord-329844-w969lczb 609 8 gathering gathering NN cord-329844-w969lczb 609 9 methods method NNS cord-329844-w969lczb 609 10 described describe VBN cord-329844-w969lczb 609 11 in in IN cord-329844-w969lczb 609 12 preceding precede VBG cord-329844-w969lczb 609 13 papers paper NNS cord-329844-w969lczb 609 14 although although IN cord-329844-w969lczb 609 15 the the DT cord-329844-w969lczb 609 16 work work NN cord-329844-w969lczb 609 17 is be VBZ cord-329844-w969lczb 609 18 described describe VBN cord-329844-w969lczb 609 19 entirely entirely RB cord-329844-w969lczb 609 20 in in IN cord-329844-w969lczb 609 21 terms term NNS cord-329844-w969lczb 609 22 of of IN cord-329844-w969lczb 609 23 standard standard JJ cord-329844-w969lczb 609 24 bioinformatics bioinformatic NNS cord-329844-w969lczb 609 25 tools tool NNS cord-329844-w969lczb 609 26 . . . cord-329844-w969lczb 610 1 These these DT cord-329844-w969lczb 610 2 knowledge knowledge NN cord-329844-w969lczb 610 3 gathering gathering NN cord-329844-w969lczb 610 4 methods method NNS cord-329844-w969lczb 610 5 are be VBP cord-329844-w969lczb 610 6 used use VBN cord-329844-w969lczb 610 7 , , , cord-329844-w969lczb 610 8 amongst amongst IN cord-329844-w969lczb 610 9 many many JJ cord-329844-w969lczb 610 10 others other NNS cord-329844-w969lczb 610 11 in in IN cord-329844-w969lczb 610 12 an an DT cord-329844-w969lczb 610 13 integrated integrated JJ cord-329844-w969lczb 610 14 way way NN cord-329844-w969lczb 610 15 , , , cord-329844-w969lczb 610 16 in in IN cord-329844-w969lczb 610 17 the the DT cord-329844-w969lczb 610 18 algorithms algorithm NNS cord-329844-w969lczb 610 19 and and CC cord-329844-w969lczb 610 20 internal internal JJ cord-329844-w969lczb 610 21 architectural architectural JJ cord-329844-w969lczb 610 22 features feature NNS cord-329844-w969lczb 610 23 of of IN cord-329844-w969lczb 610 24 the the DT cord-329844-w969lczb 610 25 BioIngine.com bioingine.com ADD cord-329844-w969lczb 610 26 , , , cord-329844-w969lczb 610 27 a a DT cord-329844-w969lczb 610 28 distributed distribute VBN cord-329844-w969lczb 610 29 system system NN cord-329844-w969lczb 610 30 developed develop VBN cord-329844-w969lczb 610 31 by by IN cord-329844-w969lczb 611 1 Ingine Ingine NNP cord-329844-w969lczb 611 2 Inc. Inc. NNP cord-329844-w969lczb 611 3 Cleveland Cleveland NNP cord-329844-w969lczb 611 4 , , , cord-329844-w969lczb 611 5 Ohio Ohio NNP cord-329844-w969lczb 611 6 , , , cord-329844-w969lczb 611 7 for for IN cord-329844-w969lczb 611 8 the the DT cord-329844-w969lczb 611 9 mining mining NN cord-329844-w969lczb 611 10 of of IN cord-329844-w969lczb 611 11 , , , cord-329844-w969lczb 611 12 and and CC cord-329844-w969lczb 611 13 inference inference NN cord-329844-w969lczb 611 14 from from IN cord-329844-w969lczb 611 15 , , , cord-329844-w969lczb 611 16 Very Very NNP cord-329844-w969lczb 611 17 Big Big NNP cord-329844-w969lczb 611 18 Data datum NNS cord-329844-w969lczb 611 19 for for IN cord-329844-w969lczb 611 20 commercial commercial JJ cord-329844-w969lczb 611 21 purposes purpose NNS cord-329844-w969lczb 611 22 . . .