id sid tid token lemma pos cord-302514-rstvf3mc 1 1 key key NN cord-302514-rstvf3mc 1 2 : : : cord-302514-rstvf3mc 2 1 cord-302514-rstvf3mc cord-302514-rstvf3mc JJ cord-302514-rstvf3mc 2 2 authors author NNS cord-302514-rstvf3mc 2 3 : : : cord-302514-rstvf3mc 2 4 Abbas Abbas NNP cord-302514-rstvf3mc 2 5 , , , cord-302514-rstvf3mc 2 6 Wasim Wasim NNP cord-302514-rstvf3mc 2 7 ; ; : cord-302514-rstvf3mc 2 8 Kumar Kumar NNP cord-302514-rstvf3mc 2 9 , , , cord-302514-rstvf3mc 2 10 Amit Amit NNP cord-302514-rstvf3mc 2 11 ; ; : cord-302514-rstvf3mc 2 12 Herbein Herbein NNP cord-302514-rstvf3mc 2 13 , , , cord-302514-rstvf3mc 2 14 Georges Georges NNP cord-302514-rstvf3mc 2 15 title title NN cord-302514-rstvf3mc 2 16 : : : cord-302514-rstvf3mc 2 17 The the DT cord-302514-rstvf3mc 2 18 eEF1A eef1a CD cord-302514-rstvf3mc 2 19 Proteins protein NNS cord-302514-rstvf3mc 2 20 : : : cord-302514-rstvf3mc 3 1 At at IN cord-302514-rstvf3mc 3 2 the the DT cord-302514-rstvf3mc 3 3 Crossroads Crossroads NNP cord-302514-rstvf3mc 3 4 of of IN cord-302514-rstvf3mc 3 5 Oncogenesis Oncogenesis NNP cord-302514-rstvf3mc 3 6 , , , cord-302514-rstvf3mc 3 7 Apoptosis Apoptosis NNP cord-302514-rstvf3mc 3 8 , , , cord-302514-rstvf3mc 3 9 and and CC cord-302514-rstvf3mc 3 10 Viral Viral NNP cord-302514-rstvf3mc 3 11 Infections Infections NNPS cord-302514-rstvf3mc 3 12 date date NN cord-302514-rstvf3mc 3 13 : : : cord-302514-rstvf3mc 3 14 2015 2015 CD cord-302514-rstvf3mc 3 15 - - HYPH cord-302514-rstvf3mc 3 16 04 04 CD cord-302514-rstvf3mc 3 17 - - HYPH cord-302514-rstvf3mc 3 18 07 07 CD cord-302514-rstvf3mc 3 19 journal journal NN cord-302514-rstvf3mc 3 20 : : : cord-302514-rstvf3mc 4 1 Front Front NNP cord-302514-rstvf3mc 4 2 Oncol Oncol NNP cord-302514-rstvf3mc 4 3 DOI DOI NNP cord-302514-rstvf3mc 4 4 : : : cord-302514-rstvf3mc 5 1 10.3389/ 10.3389/ CD cord-302514-rstvf3mc 6 1 fonc.2015.00075 fonc.2015.00075 DT cord-302514-rstvf3mc 6 2 sha sha NNP cord-302514-rstvf3mc 6 3 : : : cord-302514-rstvf3mc 7 1 3bc7abde53bcbdc7ca555c835d5ad34a67941a80 3bc7abde53bcbdc7ca555c835d5ad34a67941a80 CD cord-302514-rstvf3mc 7 2 doc_id doc_id CD cord-302514-rstvf3mc 7 3 : : : cord-302514-rstvf3mc 7 4 302514 302514 CD cord-302514-rstvf3mc 7 5 cord_uid cord_uid NNS cord-302514-rstvf3mc 7 6 : : : cord-302514-rstvf3mc 8 1 rstvf3mc rstvf3mc NNP cord-302514-rstvf3mc 9 1 Eukaryotic eukaryotic JJ cord-302514-rstvf3mc 9 2 translation translation NN cord-302514-rstvf3mc 9 3 elongation elongation NN cord-302514-rstvf3mc 9 4 factors factor NNS cord-302514-rstvf3mc 9 5 1 1 CD cord-302514-rstvf3mc 9 6 alpha alpha NN cord-302514-rstvf3mc 9 7 , , , cord-302514-rstvf3mc 9 8 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 9 9 and and CC cord-302514-rstvf3mc 9 10 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 9 11 , , , cord-302514-rstvf3mc 9 12 are be VBP cord-302514-rstvf3mc 9 13 not not RB cord-302514-rstvf3mc 9 14 only only RB cord-302514-rstvf3mc 9 15 translation translation NN cord-302514-rstvf3mc 9 16 factors factor NNS cord-302514-rstvf3mc 9 17 but but CC cord-302514-rstvf3mc 9 18 also also RB cord-302514-rstvf3mc 9 19 pleiotropic pleiotropic JJ cord-302514-rstvf3mc 9 20 proteins protein NNS cord-302514-rstvf3mc 9 21 that that WDT cord-302514-rstvf3mc 9 22 are be VBP cord-302514-rstvf3mc 9 23 highly highly RB cord-302514-rstvf3mc 9 24 expressed express VBN cord-302514-rstvf3mc 9 25 in in IN cord-302514-rstvf3mc 9 26 human human JJ cord-302514-rstvf3mc 9 27 tumors tumor NNS cord-302514-rstvf3mc 9 28 , , , cord-302514-rstvf3mc 9 29 including include VBG cord-302514-rstvf3mc 9 30 breast breast NN cord-302514-rstvf3mc 9 31 cancer cancer NN cord-302514-rstvf3mc 9 32 , , , cord-302514-rstvf3mc 9 33 ovarian ovarian JJ cord-302514-rstvf3mc 9 34 cancer cancer NN cord-302514-rstvf3mc 9 35 , , , cord-302514-rstvf3mc 9 36 and and CC cord-302514-rstvf3mc 9 37 lung lung NN cord-302514-rstvf3mc 9 38 cancer cancer NN cord-302514-rstvf3mc 9 39 . . . cord-302514-rstvf3mc 10 1 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 10 2 modulates modulate VBZ cord-302514-rstvf3mc 10 3 cytoskeleton cytoskeleton NN cord-302514-rstvf3mc 10 4 , , , cord-302514-rstvf3mc 10 5 exhibits exhibit VBZ cord-302514-rstvf3mc 10 6 chaperone chaperone NN cord-302514-rstvf3mc 10 7 - - HYPH cord-302514-rstvf3mc 10 8 like like JJ cord-302514-rstvf3mc 10 9 activity activity NN cord-302514-rstvf3mc 10 10 and and CC cord-302514-rstvf3mc 10 11 also also RB cord-302514-rstvf3mc 10 12 controls control VBZ cord-302514-rstvf3mc 10 13 cell cell NN cord-302514-rstvf3mc 10 14 proliferation proliferation NN cord-302514-rstvf3mc 10 15 and and CC cord-302514-rstvf3mc 10 16 cell cell NN cord-302514-rstvf3mc 10 17 death death NN cord-302514-rstvf3mc 10 18 . . . cord-302514-rstvf3mc 11 1 In in IN cord-302514-rstvf3mc 11 2 contrast contrast NN cord-302514-rstvf3mc 11 3 , , , cord-302514-rstvf3mc 11 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 11 5 protein protein NN cord-302514-rstvf3mc 11 6 favors favor VBZ cord-302514-rstvf3mc 11 7 oncogenesis oncogenesis NN cord-302514-rstvf3mc 11 8 as as IN cord-302514-rstvf3mc 11 9 shown show VBN cord-302514-rstvf3mc 11 10 by by IN cord-302514-rstvf3mc 11 11 the the DT cord-302514-rstvf3mc 11 12 fact fact NN cord-302514-rstvf3mc 11 13 that that IN cord-302514-rstvf3mc 11 14 overexpression overexpression NN cord-302514-rstvf3mc 11 15 of of IN cord-302514-rstvf3mc 11 16 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 11 17 leads lead VBZ cord-302514-rstvf3mc 11 18 to to IN cord-302514-rstvf3mc 11 19 cellular cellular JJ cord-302514-rstvf3mc 11 20 transformation transformation NN cord-302514-rstvf3mc 11 21 and and CC cord-302514-rstvf3mc 11 22 gives give VBZ cord-302514-rstvf3mc 11 23 rise rise NN cord-302514-rstvf3mc 11 24 to to IN cord-302514-rstvf3mc 11 25 tumors tumor NNS cord-302514-rstvf3mc 11 26 in in IN cord-302514-rstvf3mc 11 27 nude nude JJ cord-302514-rstvf3mc 11 28 mice mouse NNS cord-302514-rstvf3mc 11 29 . . . cord-302514-rstvf3mc 12 1 The the DT cord-302514-rstvf3mc 12 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 12 3 protein protein NN cord-302514-rstvf3mc 12 4 stimulates stimulate VBZ cord-302514-rstvf3mc 12 5 the the DT cord-302514-rstvf3mc 12 6 phospholipid phospholipid NN cord-302514-rstvf3mc 12 7 signaling signal VBG cord-302514-rstvf3mc 12 8 and and CC cord-302514-rstvf3mc 12 9 activates activate VBZ cord-302514-rstvf3mc 12 10 the the DT cord-302514-rstvf3mc 12 11 Akt Akt NNP cord-302514-rstvf3mc 12 12 - - HYPH cord-302514-rstvf3mc 12 13 dependent dependent JJ cord-302514-rstvf3mc 12 14 cell cell NN cord-302514-rstvf3mc 12 15 migration migration NN cord-302514-rstvf3mc 12 16 and and CC cord-302514-rstvf3mc 12 17 actin actin NN cord-302514-rstvf3mc 12 18 remodeling remodeling NN cord-302514-rstvf3mc 12 19 that that WDT cord-302514-rstvf3mc 12 20 ultimately ultimately RB cord-302514-rstvf3mc 12 21 favors favor VBZ cord-302514-rstvf3mc 12 22 tumorigenesis tumorigenesis NN cord-302514-rstvf3mc 12 23 . . . cord-302514-rstvf3mc 13 1 In in IN cord-302514-rstvf3mc 13 2 contrast contrast NN cord-302514-rstvf3mc 13 3 , , , cord-302514-rstvf3mc 13 4 inactivation inactivation NN cord-302514-rstvf3mc 13 5 of of IN cord-302514-rstvf3mc 13 6 eEF1A eef1a CD cord-302514-rstvf3mc 13 7 proteins protein NNS cord-302514-rstvf3mc 13 8 leads lead VBZ cord-302514-rstvf3mc 13 9 to to IN cord-302514-rstvf3mc 13 10 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 13 11 , , , cord-302514-rstvf3mc 13 12 neural neural JJ cord-302514-rstvf3mc 13 13 and and CC cord-302514-rstvf3mc 13 14 muscular muscular JJ cord-302514-rstvf3mc 13 15 defects defect NNS cord-302514-rstvf3mc 13 16 , , , cord-302514-rstvf3mc 13 17 and and CC cord-302514-rstvf3mc 13 18 favors favor VBZ cord-302514-rstvf3mc 13 19 apoptosis apoptosis NN cord-302514-rstvf3mc 13 20 . . . cord-302514-rstvf3mc 14 1 Finally finally RB cord-302514-rstvf3mc 14 2 , , , cord-302514-rstvf3mc 14 3 eEF1A eef1a NN cord-302514-rstvf3mc 14 4 proteins protein NNS cord-302514-rstvf3mc 14 5 interact interact VBP cord-302514-rstvf3mc 14 6 with with IN cord-302514-rstvf3mc 14 7 several several JJ cord-302514-rstvf3mc 14 8 viral viral JJ cord-302514-rstvf3mc 14 9 proteins protein NNS cord-302514-rstvf3mc 14 10 resulting result VBG cord-302514-rstvf3mc 14 11 in in IN cord-302514-rstvf3mc 14 12 enhanced enhance VBN cord-302514-rstvf3mc 14 13 viral viral JJ cord-302514-rstvf3mc 14 14 replication replication NN cord-302514-rstvf3mc 14 15 , , , cord-302514-rstvf3mc 14 16 decreased decrease VBD cord-302514-rstvf3mc 14 17 apoptosis apoptosis NN cord-302514-rstvf3mc 14 18 , , , cord-302514-rstvf3mc 14 19 and and CC cord-302514-rstvf3mc 14 20 increased increase VBN cord-302514-rstvf3mc 14 21 cellular cellular JJ cord-302514-rstvf3mc 14 22 transformation transformation NN cord-302514-rstvf3mc 14 23 . . . cord-302514-rstvf3mc 15 1 This this DT cord-302514-rstvf3mc 15 2 review review NN cord-302514-rstvf3mc 15 3 summarizes summarize VBZ cord-302514-rstvf3mc 15 4 the the DT cord-302514-rstvf3mc 15 5 recent recent JJ cord-302514-rstvf3mc 15 6 findings finding NNS cord-302514-rstvf3mc 15 7 on on IN cord-302514-rstvf3mc 15 8 eEF1A eef1a CD cord-302514-rstvf3mc 15 9 proteins protein NNS cord-302514-rstvf3mc 15 10 indicating indicate VBG cord-302514-rstvf3mc 15 11 that that IN cord-302514-rstvf3mc 15 12 eEF1A eef1a NN cord-302514-rstvf3mc 15 13 proteins protein NNS cord-302514-rstvf3mc 15 14 play play VBP cord-302514-rstvf3mc 15 15 a a DT cord-302514-rstvf3mc 15 16 critical critical JJ cord-302514-rstvf3mc 15 17 role role NN cord-302514-rstvf3mc 15 18 in in IN cord-302514-rstvf3mc 15 19 numerous numerous JJ cord-302514-rstvf3mc 15 20 human human JJ cord-302514-rstvf3mc 15 21 diseases disease NNS cord-302514-rstvf3mc 15 22 through through IN cord-302514-rstvf3mc 15 23 enhancement enhancement NN cord-302514-rstvf3mc 15 24 of of IN cord-302514-rstvf3mc 15 25 oncogenesis oncogenesis NN cord-302514-rstvf3mc 15 26 , , , cord-302514-rstvf3mc 15 27 blockade blockade NN cord-302514-rstvf3mc 15 28 of of IN cord-302514-rstvf3mc 15 29 apoptosis apoptosis NN cord-302514-rstvf3mc 15 30 , , , cord-302514-rstvf3mc 15 31 and and CC cord-302514-rstvf3mc 15 32 increased increase VBN cord-302514-rstvf3mc 15 33 viral viral JJ cord-302514-rstvf3mc 15 34 pathogenesis pathogenesis NN cord-302514-rstvf3mc 15 35 . . . cord-302514-rstvf3mc 16 1 Translation translation NN cord-302514-rstvf3mc 16 2 is be VBZ cord-302514-rstvf3mc 16 3 the the DT cord-302514-rstvf3mc 16 4 central central JJ cord-302514-rstvf3mc 16 5 event event NN cord-302514-rstvf3mc 16 6 leading lead VBG cord-302514-rstvf3mc 16 7 to to IN cord-302514-rstvf3mc 16 8 protein protein NN cord-302514-rstvf3mc 16 9 synthesis synthesis NN cord-302514-rstvf3mc 16 10 and and CC cord-302514-rstvf3mc 16 11 translation translation NN cord-302514-rstvf3mc 16 12 factors factor NNS cord-302514-rstvf3mc 16 13 are be VBP cord-302514-rstvf3mc 16 14 key key JJ cord-302514-rstvf3mc 16 15 actors actor NNS cord-302514-rstvf3mc 16 16 involved involve VBN cord-302514-rstvf3mc 16 17 in in IN cord-302514-rstvf3mc 16 18 the the DT cord-302514-rstvf3mc 16 19 translation translation NN cord-302514-rstvf3mc 16 20 process process NN cord-302514-rstvf3mc 16 21 ( ( -LRB- cord-302514-rstvf3mc 16 22 1 1 CD cord-302514-rstvf3mc 16 23 ) ) -RRB- cord-302514-rstvf3mc 16 24 ( ( -LRB- cord-302514-rstvf3mc 16 25 2 2 LS cord-302514-rstvf3mc 16 26 ) ) -RRB- cord-302514-rstvf3mc 16 27 ( ( -LRB- cord-302514-rstvf3mc 16 28 3 3 CD cord-302514-rstvf3mc 16 29 ) ) -RRB- cord-302514-rstvf3mc 16 30 . . . cord-302514-rstvf3mc 17 1 Recently recently RB cord-302514-rstvf3mc 17 2 , , , cord-302514-rstvf3mc 17 3 it -PRON- PRP cord-302514-rstvf3mc 17 4 has have VBZ cord-302514-rstvf3mc 17 5 been be VBN cord-302514-rstvf3mc 17 6 suggested suggest VBN cord-302514-rstvf3mc 17 7 that that IN cord-302514-rstvf3mc 17 8 translation translation NN cord-302514-rstvf3mc 17 9 factors factor NNS cord-302514-rstvf3mc 17 10 could could MD cord-302514-rstvf3mc 17 11 represent represent VB cord-302514-rstvf3mc 17 12 a a DT cord-302514-rstvf3mc 17 13 new new JJ cord-302514-rstvf3mc 17 14 class class NN cord-302514-rstvf3mc 17 15 of of IN cord-302514-rstvf3mc 17 16 potential potential JJ cord-302514-rstvf3mc 17 17 oncoproteins oncoprotein NNS cord-302514-rstvf3mc 17 18 that that WDT cord-302514-rstvf3mc 17 19 could could MD cord-302514-rstvf3mc 17 20 favor favor VB cord-302514-rstvf3mc 17 21 cellular cellular JJ cord-302514-rstvf3mc 17 22 transformation transformation NN cord-302514-rstvf3mc 17 23 through through IN cord-302514-rstvf3mc 17 24 protein protein NN cord-302514-rstvf3mc 17 25 translation translation NN cord-302514-rstvf3mc 17 26 infidelity infidelity NN cord-302514-rstvf3mc 17 27 , , , cord-302514-rstvf3mc 17 28 association association NN cord-302514-rstvf3mc 17 29 with with IN cord-302514-rstvf3mc 17 30 cytoskeleton cytoskeleton NN cord-302514-rstvf3mc 17 31 alterations alteration NNS cord-302514-rstvf3mc 17 32 , , , cord-302514-rstvf3mc 17 33 and and CC cord-302514-rstvf3mc 17 34 modulation modulation NN cord-302514-rstvf3mc 17 35 of of IN cord-302514-rstvf3mc 17 36 signaling signal VBG cord-302514-rstvf3mc 17 37 pathways pathway NNS cord-302514-rstvf3mc 17 38 ( ( -LRB- cord-302514-rstvf3mc 17 39 3 3 CD cord-302514-rstvf3mc 17 40 ) ) -RRB- cord-302514-rstvf3mc 17 41 ( ( -LRB- cord-302514-rstvf3mc 17 42 4 4 LS cord-302514-rstvf3mc 17 43 ) ) -RRB- cord-302514-rstvf3mc 17 44 ( ( -LRB- cord-302514-rstvf3mc 17 45 5 5 CD cord-302514-rstvf3mc 17 46 ) ) -RRB- cord-302514-rstvf3mc 17 47 . . . cord-302514-rstvf3mc 18 1 The the DT cord-302514-rstvf3mc 18 2 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 18 3 translation translation NN cord-302514-rstvf3mc 18 4 elongation elongation NN cord-302514-rstvf3mc 18 5 factors factor NNS cord-302514-rstvf3mc 18 6 1 1 CD cord-302514-rstvf3mc 18 7 alpha alpha NN cord-302514-rstvf3mc 18 8 , , , cord-302514-rstvf3mc 18 9 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 18 10 and and CC cord-302514-rstvf3mc 18 11 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 18 12 , , , cord-302514-rstvf3mc 18 13 are be VBP cord-302514-rstvf3mc 18 14 the the DT cord-302514-rstvf3mc 18 15 second second JJ cord-302514-rstvf3mc 18 16 most most RBS cord-302514-rstvf3mc 18 17 abundant abundant JJ cord-302514-rstvf3mc 18 18 protein protein NN cord-302514-rstvf3mc 18 19 ( ( -LRB- cord-302514-rstvf3mc 18 20 1 1 CD cord-302514-rstvf3mc 18 21 - - SYM cord-302514-rstvf3mc 18 22 3 3 CD cord-302514-rstvf3mc 18 23 % % NN cord-302514-rstvf3mc 18 24 of of IN cord-302514-rstvf3mc 18 25 total total JJ cord-302514-rstvf3mc 18 26 protein protein NN cord-302514-rstvf3mc 18 27 content content NN cord-302514-rstvf3mc 18 28 ) ) -RRB- cord-302514-rstvf3mc 18 29 after after IN cord-302514-rstvf3mc 18 30 actin actin NN cord-302514-rstvf3mc 18 31 and and CC cord-302514-rstvf3mc 18 32 an an DT cord-302514-rstvf3mc 18 33 important important JJ cord-302514-rstvf3mc 18 34 component component NN cord-302514-rstvf3mc 18 35 of of IN cord-302514-rstvf3mc 18 36 translation translation NN cord-302514-rstvf3mc 18 37 machinery machinery NN cord-302514-rstvf3mc 18 38 . . . cord-302514-rstvf3mc 19 1 In in IN cord-302514-rstvf3mc 19 2 its -PRON- PRP$ cord-302514-rstvf3mc 19 3 GTP gtp NN cord-302514-rstvf3mc 19 4 bound bind VBN cord-302514-rstvf3mc 19 5 form form NN cord-302514-rstvf3mc 19 6 , , , cord-302514-rstvf3mc 19 7 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 19 8 and and CC cord-302514-rstvf3mc 19 9 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 19 10 deliver deliver VB cord-302514-rstvf3mc 19 11 the the DT cord-302514-rstvf3mc 19 12 aminoacylated aminoacylate VBN cord-302514-rstvf3mc 19 13 - - HYPH cord-302514-rstvf3mc 19 14 tRNA trna NN cord-302514-rstvf3mc 19 15 to to IN cord-302514-rstvf3mc 19 16 the the DT cord-302514-rstvf3mc 19 17 A a DT cord-302514-rstvf3mc 19 18 site site NN cord-302514-rstvf3mc 19 19 of of IN cord-302514-rstvf3mc 19 20 the the DT cord-302514-rstvf3mc 19 21 ribosome ribosome NN cord-302514-rstvf3mc 19 22 for for IN cord-302514-rstvf3mc 19 23 decoding decode VBG cord-302514-rstvf3mc 19 24 of of IN cord-302514-rstvf3mc 19 25 mRNA mrna NN cord-302514-rstvf3mc 19 26 by by IN cord-302514-rstvf3mc 19 27 codon codon NN cord-302514-rstvf3mc 19 28 - - HYPH cord-302514-rstvf3mc 19 29 anticodon anticodon NN cord-302514-rstvf3mc 19 30 interactions interaction NNS cord-302514-rstvf3mc 19 31 ( ( -LRB- cord-302514-rstvf3mc 19 32 6 6 CD cord-302514-rstvf3mc 19 33 ) ) -RRB- cord-302514-rstvf3mc 19 34 . . . cord-302514-rstvf3mc 20 1 Following follow VBG cord-302514-rstvf3mc 20 2 the the DT cord-302514-rstvf3mc 20 3 hydrolysis hydrolysis NN cord-302514-rstvf3mc 20 4 of of IN cord-302514-rstvf3mc 20 5 GTP gtp NN cord-302514-rstvf3mc 20 6 , , , cord-302514-rstvf3mc 20 7 eEF1A eef1a XX cord-302514-rstvf3mc 20 8 ( ( -LRB- cord-302514-rstvf3mc 20 9 eEF1A1 eef1a1 UH cord-302514-rstvf3mc 20 10 and and CC cord-302514-rstvf3mc 20 11 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 20 12 ) ) -RRB- cord-302514-rstvf3mc 20 13 , , , cord-302514-rstvf3mc 20 14 GDP GDP NNP cord-302514-rstvf3mc 20 15 is be VBZ cord-302514-rstvf3mc 20 16 released release VBN cord-302514-rstvf3mc 20 17 from from IN cord-302514-rstvf3mc 20 18 the the DT cord-302514-rstvf3mc 20 19 ribosome ribosome NN cord-302514-rstvf3mc 20 20 ( ( -LRB- cord-302514-rstvf3mc 20 21 6 6 CD cord-302514-rstvf3mc 20 22 ) ) -RRB- cord-302514-rstvf3mc 20 23 . . . cord-302514-rstvf3mc 21 1 Thus thus RB cord-302514-rstvf3mc 21 2 , , , cord-302514-rstvf3mc 21 3 eEF1A1 eef1a1 UH cord-302514-rstvf3mc 21 4 and and CC cord-302514-rstvf3mc 21 5 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 21 6 are be VBP cord-302514-rstvf3mc 21 7 GTP gtp NN cord-302514-rstvf3mc 21 8 - - HYPH cord-302514-rstvf3mc 21 9 binding bind VBG cord-302514-rstvf3mc 21 10 proteins protein NNS cord-302514-rstvf3mc 21 11 and and CC cord-302514-rstvf3mc 21 12 consist consist VBP cord-302514-rstvf3mc 21 13 of of IN cord-302514-rstvf3mc 21 14 three three CD cord-302514-rstvf3mc 21 15 domains domain NNS cord-302514-rstvf3mc 21 16 namely namely RB cord-302514-rstvf3mc 21 17 domain domain VBP cord-302514-rstvf3mc 21 18 I -PRON- PRP cord-302514-rstvf3mc 21 19 , , , cord-302514-rstvf3mc 21 20 domain domain NN cord-302514-rstvf3mc 21 21 II II NNP cord-302514-rstvf3mc 21 22 , , , cord-302514-rstvf3mc 21 23 and and CC cord-302514-rstvf3mc 21 24 domain domain NN cord-302514-rstvf3mc 21 25 III iii CD cord-302514-rstvf3mc 21 26 . . . cord-302514-rstvf3mc 22 1 Domain domain NN cord-302514-rstvf3mc 23 1 I -PRON- PRP cord-302514-rstvf3mc 23 2 spans span VBZ cord-302514-rstvf3mc 23 3 over over IN cord-302514-rstvf3mc 23 4 1 1 CD cord-302514-rstvf3mc 23 5 - - SYM cord-302514-rstvf3mc 23 6 240 240 CD cord-302514-rstvf3mc 23 7 residues residue NNS cord-302514-rstvf3mc 23 8 , , , cord-302514-rstvf3mc 23 9 which which WDT cord-302514-rstvf3mc 23 10 made make VBD cord-302514-rstvf3mc 23 11 up up RP cord-302514-rstvf3mc 23 12 of of IN cord-302514-rstvf3mc 23 13 a a DT cord-302514-rstvf3mc 23 14 Rossmann Rossmann NNP cord-302514-rstvf3mc 23 15 - - HYPH cord-302514-rstvf3mc 23 16 fold fold JJ cord-302514-rstvf3mc 23 17 topology topology NN cord-302514-rstvf3mc 23 18 . . . cord-302514-rstvf3mc 24 1 Domain Domain NNP cord-302514-rstvf3mc 24 2 II II NNP cord-302514-rstvf3mc 24 3 ( ( -LRB- cord-302514-rstvf3mc 24 4 241 241 CD cord-302514-rstvf3mc 24 5 - - SYM cord-302514-rstvf3mc 24 6 336 336 CD cord-302514-rstvf3mc 24 7 amino amino JJ cord-302514-rstvf3mc 24 8 acids acid NNS cord-302514-rstvf3mc 24 9 ) ) -RRB- cord-302514-rstvf3mc 24 10 and and CC cord-302514-rstvf3mc 24 11 domain domain NN cord-302514-rstvf3mc 24 12 III III NNP cord-302514-rstvf3mc 24 13 ( ( -LRB- cord-302514-rstvf3mc 24 14 residues residue NNS cord-302514-rstvf3mc 24 15 337 337 CD cord-302514-rstvf3mc 24 16 - - SYM cord-302514-rstvf3mc 24 17 443 443 CD cord-302514-rstvf3mc 24 18 ) ) -RRB- cord-302514-rstvf3mc 24 19 consist consist VBP cord-302514-rstvf3mc 24 20 of of IN cord-302514-rstvf3mc 24 21 beta beta JJ cord-302514-rstvf3mc 24 22 strands strand NNS cord-302514-rstvf3mc 24 23 and and CC cord-302514-rstvf3mc 24 24 each each DT cord-302514-rstvf3mc 24 25 domain domain NN cord-302514-rstvf3mc 24 26 contains contain VBZ cord-302514-rstvf3mc 24 27 two two CD cord-302514-rstvf3mc 24 28 beta beta NN cord-302514-rstvf3mc 24 29 sheets sheet NNS cord-302514-rstvf3mc 24 30 that that WDT cord-302514-rstvf3mc 24 31 form form VBP cord-302514-rstvf3mc 24 32 the the DT cord-302514-rstvf3mc 24 33 beta beta NN cord-302514-rstvf3mc 24 34 barrel barrel NN cord-302514-rstvf3mc 24 35 ( ( -LRB- cord-302514-rstvf3mc 24 36 7 7 CD cord-302514-rstvf3mc 24 37 - - SYM cord-302514-rstvf3mc 24 38 10 10 CD cord-302514-rstvf3mc 24 39 ) ) -RRB- cord-302514-rstvf3mc 25 1 ( ( -LRB- cord-302514-rstvf3mc 25 2 Figure figure NN cord-302514-rstvf3mc 25 3 1 1 CD cord-302514-rstvf3mc 25 4 ) ) -RRB- cord-302514-rstvf3mc 25 5 . . . cord-302514-rstvf3mc 26 1 There there EX cord-302514-rstvf3mc 26 2 are be VBP cord-302514-rstvf3mc 26 3 two two CD cord-302514-rstvf3mc 26 4 known know VBN cord-302514-rstvf3mc 26 5 isoforms isoform NNS cord-302514-rstvf3mc 26 6 of of IN cord-302514-rstvf3mc 26 7 protein protein NN cord-302514-rstvf3mc 26 8 eEF1A eef1a NN cord-302514-rstvf3mc 26 9 , , , cord-302514-rstvf3mc 26 10 i.e. i.e. FW cord-302514-rstvf3mc 26 11 , , , cord-302514-rstvf3mc 26 12 eEF1A1 eef1a1 UH cord-302514-rstvf3mc 26 13 and and CC cord-302514-rstvf3mc 26 14 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 26 15 . . . cord-302514-rstvf3mc 27 1 The the DT cord-302514-rstvf3mc 27 2 cellular cellular JJ cord-302514-rstvf3mc 27 3 expression expression NN cord-302514-rstvf3mc 27 4 of of IN cord-302514-rstvf3mc 27 5 eEF1A eef1a NN cord-302514-rstvf3mc 27 6 is be VBZ cord-302514-rstvf3mc 27 7 divided divide VBN cord-302514-rstvf3mc 27 8 into into IN cord-302514-rstvf3mc 27 9 three three CD cord-302514-rstvf3mc 27 10 classes class NNS cord-302514-rstvf3mc 27 11 . . . cord-302514-rstvf3mc 28 1 First first RB cord-302514-rstvf3mc 28 2 are be VBP cord-302514-rstvf3mc 28 3 the the DT cord-302514-rstvf3mc 28 4 majority majority NN cord-302514-rstvf3mc 28 5 of of IN cord-302514-rstvf3mc 28 6 cell cell NN cord-302514-rstvf3mc 28 7 types type NNS cord-302514-rstvf3mc 28 8 that that WDT cord-302514-rstvf3mc 28 9 express express VBP cord-302514-rstvf3mc 28 10 only only RB cord-302514-rstvf3mc 28 11 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 28 12 . . . cord-302514-rstvf3mc 29 1 Second second JJ cord-302514-rstvf3mc 29 2 , , , cord-302514-rstvf3mc 29 3 neurons neuron NNS cord-302514-rstvf3mc 29 4 and and CC cord-302514-rstvf3mc 29 5 muscle muscle NN cord-302514-rstvf3mc 29 6 cells cell NNS cord-302514-rstvf3mc 29 7 that that WDT cord-302514-rstvf3mc 29 8 express express VBP cord-302514-rstvf3mc 29 9 only only RB cord-302514-rstvf3mc 29 10 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 29 11 . . . cord-302514-rstvf3mc 30 1 Third third JJ cord-302514-rstvf3mc 30 2 class class NN cord-302514-rstvf3mc 30 3 belongs belong VBZ cord-302514-rstvf3mc 30 4 to to IN cord-302514-rstvf3mc 30 5 certain certain JJ cord-302514-rstvf3mc 30 6 tumor tumor NN cord-302514-rstvf3mc 30 7 cell cell NN cord-302514-rstvf3mc 30 8 types type NNS cord-302514-rstvf3mc 30 9 and and CC cord-302514-rstvf3mc 30 10 cell cell NN cord-302514-rstvf3mc 30 11 lines line NNS cord-302514-rstvf3mc 30 12 that that WDT cord-302514-rstvf3mc 30 13 express express VBP cord-302514-rstvf3mc 30 14 both both DT cord-302514-rstvf3mc 30 15 eEF1A eef1a CD cord-302514-rstvf3mc 30 16 isoforms isoform NNS cord-302514-rstvf3mc 30 17 ( ( -LRB- cord-302514-rstvf3mc 30 18 11 11 CD cord-302514-rstvf3mc 30 19 ) ) -RRB- cord-302514-rstvf3mc 30 20 ( ( -LRB- cord-302514-rstvf3mc 30 21 12 12 CD cord-302514-rstvf3mc 30 22 ) ) -RRB- cord-302514-rstvf3mc 30 23 ( ( -LRB- cord-302514-rstvf3mc 30 24 13 13 CD cord-302514-rstvf3mc 30 25 ) ) -RRB- cord-302514-rstvf3mc 30 26 . . . cord-302514-rstvf3mc 31 1 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 31 2 protein protein NN cord-302514-rstvf3mc 31 3 has have VBZ cord-302514-rstvf3mc 31 4 been be VBN cord-302514-rstvf3mc 31 5 mapped map VBN cord-302514-rstvf3mc 31 6 on on IN cord-302514-rstvf3mc 31 7 chromosomes chromosome NNS cord-302514-rstvf3mc 31 8 6q14 6q14 CD cord-302514-rstvf3mc 31 9 . . . cord-302514-rstvf3mc 32 1 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 32 2 protein protein NN cord-302514-rstvf3mc 32 3 shares share VBZ cord-302514-rstvf3mc 32 4 homology homology NN cord-302514-rstvf3mc 32 5 with with IN cord-302514-rstvf3mc 32 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 32 7 protein protein NN cord-302514-rstvf3mc 32 8 at at IN cord-302514-rstvf3mc 32 9 the the DT cord-302514-rstvf3mc 32 10 nucleotide nucleotide JJ cord-302514-rstvf3mc 32 11 level level NN cord-302514-rstvf3mc 32 12 ( ( -LRB- cord-302514-rstvf3mc 32 13 75 75 CD cord-302514-rstvf3mc 32 14 % % NN cord-302514-rstvf3mc 32 15 ) ) -RRB- cord-302514-rstvf3mc 32 16 and and CC cord-302514-rstvf3mc 32 17 amino amino NN cord-302514-rstvf3mc 32 18 acid acid NN cord-302514-rstvf3mc 32 19 level level NN cord-302514-rstvf3mc 32 20 ( ( -LRB- cord-302514-rstvf3mc 32 21 96 96 CD cord-302514-rstvf3mc 32 22 % % NN cord-302514-rstvf3mc 32 23 ) ) -RRB- cord-302514-rstvf3mc 32 24 . . . cord-302514-rstvf3mc 33 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 33 2 does do VBZ cord-302514-rstvf3mc 33 3 not not RB cord-302514-rstvf3mc 33 4 bind bind VB cord-302514-rstvf3mc 33 5 GDP GDP NNP cord-302514-rstvf3mc 33 6 and and CC cord-302514-rstvf3mc 33 7 GTP GTP NNP cord-302514-rstvf3mc 33 8 with with IN cord-302514-rstvf3mc 33 9 the the DT cord-302514-rstvf3mc 33 10 same same JJ cord-302514-rstvf3mc 33 11 relative relative JJ cord-302514-rstvf3mc 33 12 affinity affinity NN cord-302514-rstvf3mc 33 13 as as IN cord-302514-rstvf3mc 33 14 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 33 15 . . . cord-302514-rstvf3mc 34 1 The the DT cord-302514-rstvf3mc 34 2 GDP GDP NNP cord-302514-rstvf3mc 34 3 dissociation dissociation NN cord-302514-rstvf3mc 34 4 rate rate NN cord-302514-rstvf3mc 34 5 constant constant NN cord-302514-rstvf3mc 34 6 is be VBZ cord-302514-rstvf3mc 34 7 seven seven CD cord-302514-rstvf3mc 34 8 times time NNS cord-302514-rstvf3mc 34 9 higher high JJR cord-302514-rstvf3mc 34 10 for for IN cord-302514-rstvf3mc 34 11 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 34 12 than than IN cord-302514-rstvf3mc 34 13 for for IN cord-302514-rstvf3mc 34 14 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 34 15 . . . cord-302514-rstvf3mc 35 1 In in IN cord-302514-rstvf3mc 35 2 addition addition NN cord-302514-rstvf3mc 35 3 , , , cord-302514-rstvf3mc 35 4 the the DT cord-302514-rstvf3mc 35 5 nucleotide nucleotide JJ cord-302514-rstvf3mc 35 6 preference preference NN cord-302514-rstvf3mc 35 7 ratio ratio NN cord-302514-rstvf3mc 35 8 ( ( -LRB- cord-302514-rstvf3mc 35 9 GDP GDP NNP cord-302514-rstvf3mc 35 10 / / SYM cord-302514-rstvf3mc 35 11 GTP GTP NNP cord-302514-rstvf3mc 35 12 ) ) -RRB- cord-302514-rstvf3mc 35 13 for for IN cord-302514-rstvf3mc 35 14 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 35 15 is be VBZ cord-302514-rstvf3mc 35 16 0.82 0.82 CD cord-302514-rstvf3mc 35 17 and and CC cord-302514-rstvf3mc 35 18 for for IN cord-302514-rstvf3mc 35 19 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 35 20 is be VBZ cord-302514-rstvf3mc 35 21 1.50 1.50 CD cord-302514-rstvf3mc 35 22 ( ( -LRB- cord-302514-rstvf3mc 35 23 14 14 CD cord-302514-rstvf3mc 35 24 ) ) -RRB- cord-302514-rstvf3mc 36 1 ( ( -LRB- cord-302514-rstvf3mc 36 2 15 15 CD cord-302514-rstvf3mc 36 3 ) ) -RRB- cord-302514-rstvf3mc 36 4 ( ( -LRB- cord-302514-rstvf3mc 36 5 16 16 CD cord-302514-rstvf3mc 36 6 ) ) -RRB- cord-302514-rstvf3mc 36 7 ( ( -LRB- cord-302514-rstvf3mc 36 8 17 17 CD cord-302514-rstvf3mc 36 9 ) ) -RRB- cord-302514-rstvf3mc 36 10 . . . cord-302514-rstvf3mc 37 1 Furthermore furthermore RB cord-302514-rstvf3mc 37 2 , , , cord-302514-rstvf3mc 37 3 eEF1A eEF1A '' cord-302514-rstvf3mc 37 4 has have VBZ cord-302514-rstvf3mc 37 5 been be VBN cord-302514-rstvf3mc 37 6 shown show VBN cord-302514-rstvf3mc 37 7 to to TO cord-302514-rstvf3mc 37 8 be be VB cord-302514-rstvf3mc 37 9 a a DT cord-302514-rstvf3mc 37 10 novel novel JJ cord-302514-rstvf3mc 37 11 component component NN cord-302514-rstvf3mc 37 12 of of IN cord-302514-rstvf3mc 37 13 the the DT cord-302514-rstvf3mc 37 14 nuclear nuclear JJ cord-302514-rstvf3mc 37 15 export export NN cord-302514-rstvf3mc 37 16 machinery machinery NN cord-302514-rstvf3mc 37 17 in in IN cord-302514-rstvf3mc 37 18 mammalian mammalian JJ cord-302514-rstvf3mc 37 19 cells cell NNS cord-302514-rstvf3mc 37 20 and and CC cord-302514-rstvf3mc 37 21 is be VBZ cord-302514-rstvf3mc 37 22 involved involve VBN cord-302514-rstvf3mc 37 23 in in IN cord-302514-rstvf3mc 37 24 the the DT cord-302514-rstvf3mc 37 25 nuclear nuclear JJ cord-302514-rstvf3mc 37 26 export export NN cord-302514-rstvf3mc 37 27 of of IN cord-302514-rstvf3mc 37 28 specific specific JJ cord-302514-rstvf3mc 37 29 proteins protein NNS cord-302514-rstvf3mc 37 30 such such JJ cord-302514-rstvf3mc 37 31 as as IN cord-302514-rstvf3mc 37 32 VHL VHL NNP cord-302514-rstvf3mc 37 33 van van NNP cord-302514-rstvf3mc 37 34 Hippel Hippel NNP cord-302514-rstvf3mc 37 35 - - HYPH cord-302514-rstvf3mc 37 36 Lindau Lindau NNP cord-302514-rstvf3mc 37 37 ( ( -LRB- cord-302514-rstvf3mc 37 38 VHL VHL NNP cord-302514-rstvf3mc 37 39 ) ) -RRB- cord-302514-rstvf3mc 37 40 tumor tumor NN cord-302514-rstvf3mc 37 41 suppressor suppressor NN cord-302514-rstvf3mc 37 42 and and CC cord-302514-rstvf3mc 37 43 poly(A)-binding poly(A)-binding NNP cord-302514-rstvf3mc 37 44 protein protein NN cord-302514-rstvf3mc 37 45 ( ( -LRB- cord-302514-rstvf3mc 37 46 PABP1 pabp1 NN cord-302514-rstvf3mc 37 47 ) ) -RRB- cord-302514-rstvf3mc 37 48 ( ( -LRB- cord-302514-rstvf3mc 37 49 18 18 CD cord-302514-rstvf3mc 37 50 ) ) -RRB- cord-302514-rstvf3mc 37 51 . . . cord-302514-rstvf3mc 38 1 The the DT cord-302514-rstvf3mc 38 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 38 3 gene gene NN cord-302514-rstvf3mc 38 4 is be VBZ cord-302514-rstvf3mc 38 5 present present JJ cord-302514-rstvf3mc 38 6 in in IN cord-302514-rstvf3mc 38 7 the the DT cord-302514-rstvf3mc 38 8 common common JJ cord-302514-rstvf3mc 38 9 ancestor ancestor NN cord-302514-rstvf3mc 38 10 of of IN cord-302514-rstvf3mc 38 11 eukaryotes eukaryote NNS cord-302514-rstvf3mc 38 12 ( ( -LRB- cord-302514-rstvf3mc 38 13 Table table NN cord-302514-rstvf3mc 38 14 1 1 CD cord-302514-rstvf3mc 38 15 ; ; : cord-302514-rstvf3mc 38 16 Figure figure NN cord-302514-rstvf3mc 38 17 2 2 CD cord-302514-rstvf3mc 38 18 ) ) -RRB- cord-302514-rstvf3mc 38 19 . . . cord-302514-rstvf3mc 39 1 Human human JJ cord-302514-rstvf3mc 39 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 39 3 gene gene NN cord-302514-rstvf3mc 39 4 spans span VBZ cord-302514-rstvf3mc 39 5 approximately approximately RB cord-302514-rstvf3mc 39 6 12 12 CD cord-302514-rstvf3mc 39 7 kb kb NNP cord-302514-rstvf3mc 39 8 human human JJ cord-302514-rstvf3mc 39 9 genome genome NN cord-302514-rstvf3mc 39 10 sequence sequence NN cord-302514-rstvf3mc 39 11 , , , cord-302514-rstvf3mc 39 12 which which WDT cord-302514-rstvf3mc 39 13 consists consist VBZ cord-302514-rstvf3mc 39 14 of of IN cord-302514-rstvf3mc 39 15 eight eight CD cord-302514-rstvf3mc 39 16 exons exon NNS cord-302514-rstvf3mc 39 17 and and CC cord-302514-rstvf3mc 39 18 seven seven CD cord-302514-rstvf3mc 39 19 introns intron NNS cord-302514-rstvf3mc 39 20 plus plus CC cord-302514-rstvf3mc 39 21 2 2 CD cord-302514-rstvf3mc 39 22 kb kb NNP cord-302514-rstvf3mc 39 23 upstream upstream NNP cord-302514-rstvf3mc 39 24 promoter promoter NN cord-302514-rstvf3mc 39 25 region region NN cord-302514-rstvf3mc 39 26 , , , cord-302514-rstvf3mc 39 27 and and CC cord-302514-rstvf3mc 39 28 has have VBZ cord-302514-rstvf3mc 39 29 been be VBN cord-302514-rstvf3mc 39 30 mapped map VBN cord-302514-rstvf3mc 39 31 on on IN cord-302514-rstvf3mc 39 32 chromosome chromosome NN cord-302514-rstvf3mc 39 33 20q13.3 20q13.3 CD cord-302514-rstvf3mc 39 34 . . . cord-302514-rstvf3mc 40 1 Analysis analysis NN cord-302514-rstvf3mc 40 2 of of IN cord-302514-rstvf3mc 40 3 the the DT cord-302514-rstvf3mc 40 4 region region NN cord-302514-rstvf3mc 40 5 −2064 −2064 NNP cord-302514-rstvf3mc 40 6 to to IN cord-302514-rstvf3mc 40 7 +220 +220 NNP cord-302514-rstvf3mc 40 8 reveals reveal VBZ cord-302514-rstvf3mc 40 9 that that IN cord-302514-rstvf3mc 40 10 the the DT cord-302514-rstvf3mc 40 11 promoter promoter NN cord-302514-rstvf3mc 40 12 region region NN cord-302514-rstvf3mc 40 13 contains contain VBZ cord-302514-rstvf3mc 40 14 the the DT cord-302514-rstvf3mc 40 15 binding bind VBG cord-302514-rstvf3mc 40 16 sites site NNS cord-302514-rstvf3mc 40 17 for for IN cord-302514-rstvf3mc 40 18 several several JJ cord-302514-rstvf3mc 40 19 important important JJ cord-302514-rstvf3mc 40 20 cis cis JJ cord-302514-rstvf3mc 40 21 - - HYPH cord-302514-rstvf3mc 40 22 regulatory regulatory JJ cord-302514-rstvf3mc 40 23 elements element NNS cord-302514-rstvf3mc 40 24 ( ( -LRB- cord-302514-rstvf3mc 40 25 E E NNS cord-302514-rstvf3mc 40 26 - - NNS cord-302514-rstvf3mc 40 27 boxes box NNS cord-302514-rstvf3mc 40 28 , , , cord-302514-rstvf3mc 40 29 EGR egr NN cord-302514-rstvf3mc 40 30 family family NN cord-302514-rstvf3mc 40 31 proteins protein NNS cord-302514-rstvf3mc 40 32 , , , cord-302514-rstvf3mc 40 33 GATA GATA NNP cord-302514-rstvf3mc 40 34 motif motif NN cord-302514-rstvf3mc 40 35 , , , cord-302514-rstvf3mc 40 36 and and CC cord-302514-rstvf3mc 40 37 MEF MEF NNP cord-302514-rstvf3mc 40 38 binding bind VBG cord-302514-rstvf3mc 40 39 site site NN cord-302514-rstvf3mc 40 40 ) ) -RRB- cord-302514-rstvf3mc 40 41 with with IN cord-302514-rstvf3mc 40 42 no no DT cord-302514-rstvf3mc 40 43 TATA TATA NNP cord-302514-rstvf3mc 40 44 elements element NNS cord-302514-rstvf3mc 40 45 ( ( -LRB- cord-302514-rstvf3mc 40 46 Figure figure NN cord-302514-rstvf3mc 40 47 3 3 CD cord-302514-rstvf3mc 40 48 ) ) -RRB- cord-302514-rstvf3mc 40 49 . . . cord-302514-rstvf3mc 41 1 The the DT cord-302514-rstvf3mc 41 2 core core NN cord-302514-rstvf3mc 41 3 region region NN cord-302514-rstvf3mc 41 4 of of IN cord-302514-rstvf3mc 41 5 the the DT cord-302514-rstvf3mc 41 6 promoter promoter NN cord-302514-rstvf3mc 41 7 is be VBZ cord-302514-rstvf3mc 41 8 mapped map VBN cord-302514-rstvf3mc 41 9 from from IN cord-302514-rstvf3mc 41 10 position position NN cord-302514-rstvf3mc 41 11 −16 −16 NNP cord-302514-rstvf3mc 41 12 to to IN cord-302514-rstvf3mc 41 13 +92 +92 NN cord-302514-rstvf3mc 41 14 ( ( -LRB- cord-302514-rstvf3mc 41 15 9 9 CD cord-302514-rstvf3mc 41 16 , , , cord-302514-rstvf3mc 41 17 19 19 CD cord-302514-rstvf3mc 41 18 ) ) -RRB- cord-302514-rstvf3mc 41 19 . . . cord-302514-rstvf3mc 42 1 Beyond beyond IN cord-302514-rstvf3mc 42 2 its -PRON- PRP$ cord-302514-rstvf3mc 42 3 central central JJ cord-302514-rstvf3mc 42 4 role role NN cord-302514-rstvf3mc 42 5 in in IN cord-302514-rstvf3mc 42 6 translation translation NN cord-302514-rstvf3mc 42 7 machinery machinery NN cord-302514-rstvf3mc 42 8 , , , cord-302514-rstvf3mc 42 9 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 42 10 plays play VBZ cord-302514-rstvf3mc 42 11 an an DT cord-302514-rstvf3mc 42 12 important important JJ cord-302514-rstvf3mc 42 13 role role NN cord-302514-rstvf3mc 42 14 in in IN cord-302514-rstvf3mc 42 15 cell cell NN cord-302514-rstvf3mc 42 16 cycle cycle NN cord-302514-rstvf3mc 42 17 regulation regulation NN cord-302514-rstvf3mc 42 18 , , , cord-302514-rstvf3mc 42 19 heat heat NN cord-302514-rstvf3mc 42 20 - - HYPH cord-302514-rstvf3mc 42 21 shock shock NN cord-302514-rstvf3mc 42 22 response response NN cord-302514-rstvf3mc 42 23 , , , cord-302514-rstvf3mc 42 24 aging aging NN cord-302514-rstvf3mc 42 25 , , , cord-302514-rstvf3mc 42 26 posttranslational posttranslational JJ cord-302514-rstvf3mc 42 27 modifications modification NNS cord-302514-rstvf3mc 42 28 , , , cord-302514-rstvf3mc 42 29 and and CC cord-302514-rstvf3mc 42 30 signal signal NN cord-302514-rstvf3mc 42 31 transduction transduction NN cord-302514-rstvf3mc 42 32 ( ( -LRB- cord-302514-rstvf3mc 42 33 20 20 CD cord-302514-rstvf3mc 42 34 ) ) -RRB- cord-302514-rstvf3mc 42 35 ( ( -LRB- cord-302514-rstvf3mc 42 36 21 21 CD cord-302514-rstvf3mc 42 37 ) ) -RRB- cord-302514-rstvf3mc 42 38 ( ( -LRB- cord-302514-rstvf3mc 42 39 22 22 CD cord-302514-rstvf3mc 42 40 ) ) -RRB- cord-302514-rstvf3mc 42 41 ( ( -LRB- cord-302514-rstvf3mc 42 42 23 23 CD cord-302514-rstvf3mc 42 43 ) ) -RRB- cord-302514-rstvf3mc 42 44 . . . cord-302514-rstvf3mc 43 1 Protein protein NN cord-302514-rstvf3mc 43 2 synthesis synthesis NN cord-302514-rstvf3mc 43 3 is be VBZ cord-302514-rstvf3mc 43 4 one one CD cord-302514-rstvf3mc 43 5 of of IN cord-302514-rstvf3mc 43 6 the the DT cord-302514-rstvf3mc 43 7 most most RBS cord-302514-rstvf3mc 43 8 sophisticated sophisticated JJ cord-302514-rstvf3mc 43 9 biochemical biochemical JJ cord-302514-rstvf3mc 43 10 processes process NNS cord-302514-rstvf3mc 43 11 occurring occur VBG cord-302514-rstvf3mc 43 12 in in IN cord-302514-rstvf3mc 43 13 the the DT cord-302514-rstvf3mc 43 14 cell cell NN cord-302514-rstvf3mc 43 15 , , , cord-302514-rstvf3mc 43 16 which which WDT cord-302514-rstvf3mc 43 17 requires require VBZ cord-302514-rstvf3mc 43 18 hundred hundred CD cord-302514-rstvf3mc 43 19 of of IN cord-302514-rstvf3mc 43 20 proteins protein NNS cord-302514-rstvf3mc 43 21 , , , cord-302514-rstvf3mc 43 22 including include VBG cord-302514-rstvf3mc 43 23 eEF1A eef1a CD cord-302514-rstvf3mc 43 24 proteins protein NNS cord-302514-rstvf3mc 43 25 , , , cord-302514-rstvf3mc 43 26 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 43 27 and and CC cord-302514-rstvf3mc 43 28 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 43 29 . . . cord-302514-rstvf3mc 44 1 Besides besides IN cord-302514-rstvf3mc 44 2 the the DT cord-302514-rstvf3mc 44 3 role role NN cord-302514-rstvf3mc 44 4 of of IN cord-302514-rstvf3mc 44 5 eEF1A eef1a CD cord-302514-rstvf3mc 44 6 proteins protein NNS cord-302514-rstvf3mc 44 7 in in IN cord-302514-rstvf3mc 44 8 the the DT cord-302514-rstvf3mc 44 9 translational translational JJ cord-302514-rstvf3mc 44 10 process process NN cord-302514-rstvf3mc 44 11 , , , cord-302514-rstvf3mc 44 12 an an DT cord-302514-rstvf3mc 44 13 increasing increase VBG cord-302514-rstvf3mc 44 14 series series NN cord-302514-rstvf3mc 44 15 of of IN cord-302514-rstvf3mc 44 16 data datum NNS cord-302514-rstvf3mc 44 17 are be VBP cord-302514-rstvf3mc 44 18 presently presently RB cord-302514-rstvf3mc 44 19 emerging emerge VBG cord-302514-rstvf3mc 44 20 about about IN cord-302514-rstvf3mc 44 21 the the DT cord-302514-rstvf3mc 44 22 non non JJ cord-302514-rstvf3mc 44 23 - - JJ cord-302514-rstvf3mc 44 24 canonical canonical JJ cord-302514-rstvf3mc 44 25 roles role NNS cord-302514-rstvf3mc 44 26 of of IN cord-302514-rstvf3mc 44 27 these these DT cord-302514-rstvf3mc 44 28 proteins protein NNS cord-302514-rstvf3mc 44 29 in in IN cord-302514-rstvf3mc 44 30 oncogenesis oncogenesis NN cord-302514-rstvf3mc 44 31 , , , cord-302514-rstvf3mc 44 32 modulation modulation NN cord-302514-rstvf3mc 44 33 of of IN cord-302514-rstvf3mc 44 34 apoptosis apoptosis NN cord-302514-rstvf3mc 44 35 and and CC cord-302514-rstvf3mc 44 36 viral viral JJ cord-302514-rstvf3mc 44 37 pathogenesis pathogenesis NN cord-302514-rstvf3mc 44 38 ( ( -LRB- cord-302514-rstvf3mc 44 39 1 1 CD cord-302514-rstvf3mc 44 40 , , , cord-302514-rstvf3mc 44 41 20 20 CD cord-302514-rstvf3mc 44 42 ) ) -RRB- cord-302514-rstvf3mc 44 43 . . . cord-302514-rstvf3mc 44 44 _SP cord-302514-rstvf3mc 45 1 Breast breast NN cord-302514-rstvf3mc 45 2 cancer cancer NN cord-302514-rstvf3mc 45 3 is be VBZ cord-302514-rstvf3mc 45 4 the the DT cord-302514-rstvf3mc 45 5 most most RBS cord-302514-rstvf3mc 45 6 common common JJ cord-302514-rstvf3mc 45 7 cancer cancer NN cord-302514-rstvf3mc 45 8 in in IN cord-302514-rstvf3mc 45 9 women woman NNS cord-302514-rstvf3mc 45 10 both both CC cord-302514-rstvf3mc 45 11 in in IN cord-302514-rstvf3mc 45 12 the the DT cord-302514-rstvf3mc 45 13 developing develop VBG cord-302514-rstvf3mc 45 14 and and CC cord-302514-rstvf3mc 45 15 developed developed JJ cord-302514-rstvf3mc 45 16 world world NN cord-302514-rstvf3mc 45 17 ; ; : cord-302514-rstvf3mc 45 18 there there EX cord-302514-rstvf3mc 45 19 are be VBP cord-302514-rstvf3mc 45 20 an an DT cord-302514-rstvf3mc 45 21 estimated estimated JJ cord-302514-rstvf3mc 45 22 1 1 CD cord-302514-rstvf3mc 45 23 million million CD cord-302514-rstvf3mc 45 24 new new JJ cord-302514-rstvf3mc 45 25 cases case NNS cord-302514-rstvf3mc 45 26 per per IN cord-302514-rstvf3mc 45 27 year year NN cord-302514-rstvf3mc 45 28 . . . cord-302514-rstvf3mc 46 1 The the DT cord-302514-rstvf3mc 46 2 use use NN cord-302514-rstvf3mc 46 3 of of IN cord-302514-rstvf3mc 46 4 gene gene NN cord-302514-rstvf3mc 46 5 signature signature NN cord-302514-rstvf3mc 46 6 or or CC cord-302514-rstvf3mc 46 7 the the DT cord-302514-rstvf3mc 46 8 identification identification NN cord-302514-rstvf3mc 46 9 of of IN cord-302514-rstvf3mc 46 10 changes change NNS cord-302514-rstvf3mc 46 11 in in IN cord-302514-rstvf3mc 46 12 gene gene NN cord-302514-rstvf3mc 46 13 expression expression NN cord-302514-rstvf3mc 46 14 in in IN cord-302514-rstvf3mc 46 15 breast breast NN cord-302514-rstvf3mc 46 16 tumors tumor NNS cord-302514-rstvf3mc 46 17 relative relative JJ cord-302514-rstvf3mc 46 18 to to IN cord-302514-rstvf3mc 46 19 normal normal JJ cord-302514-rstvf3mc 46 20 surrounding surround VBG cord-302514-rstvf3mc 46 21 tissue tissue NN cord-302514-rstvf3mc 46 22 is be VBZ cord-302514-rstvf3mc 46 23 of of IN cord-302514-rstvf3mc 46 24 great great JJ cord-302514-rstvf3mc 46 25 importance importance NN cord-302514-rstvf3mc 46 26 in in IN cord-302514-rstvf3mc 46 27 terms term NNS cord-302514-rstvf3mc 46 28 of of IN cord-302514-rstvf3mc 46 29 prognostic prognostic JJ cord-302514-rstvf3mc 46 30 indicators indicator NNS cord-302514-rstvf3mc 46 31 and and CC cord-302514-rstvf3mc 46 32 therapeutic therapeutic JJ cord-302514-rstvf3mc 46 33 targets target NNS cord-302514-rstvf3mc 46 34 ( ( -LRB- cord-302514-rstvf3mc 46 35 24 24 CD cord-302514-rstvf3mc 46 36 ) ) -RRB- cord-302514-rstvf3mc 46 37 . . . cord-302514-rstvf3mc 47 1 The the DT cord-302514-rstvf3mc 47 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 47 3 is be VBZ cord-302514-rstvf3mc 47 4 hardly hardly RB cord-302514-rstvf3mc 47 5 detectable detectable JJ cord-302514-rstvf3mc 47 6 in in IN cord-302514-rstvf3mc 47 7 normal normal JJ cord-302514-rstvf3mc 47 8 human human JJ cord-302514-rstvf3mc 47 9 breast breast NN cord-302514-rstvf3mc 47 10 tissue tissue NN cord-302514-rstvf3mc 47 11 but but CC cord-302514-rstvf3mc 47 12 the the DT cord-302514-rstvf3mc 47 13 expression expression NN cord-302514-rstvf3mc 47 14 of of IN cord-302514-rstvf3mc 47 15 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 47 16 is be VBZ cord-302514-rstvf3mc 47 17 strongly strongly RB cord-302514-rstvf3mc 47 18 upregulated upregulate VBN cord-302514-rstvf3mc 47 19 in in IN cord-302514-rstvf3mc 47 20 most most JJS cord-302514-rstvf3mc 47 21 of of IN cord-302514-rstvf3mc 47 22 breast breast NN cord-302514-rstvf3mc 47 23 tumors tumor NNS cord-302514-rstvf3mc 47 24 ( ( -LRB- cord-302514-rstvf3mc 47 25 25 25 CD cord-302514-rstvf3mc 47 26 , , , cord-302514-rstvf3mc 47 27 26 26 CD cord-302514-rstvf3mc 47 28 ) ) -RRB- cord-302514-rstvf3mc 47 29 . . . cord-302514-rstvf3mc 48 1 High high JJ cord-302514-rstvf3mc 48 2 levels level NNS cord-302514-rstvf3mc 48 3 of of IN cord-302514-rstvf3mc 48 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 48 5 proteins protein NNS cord-302514-rstvf3mc 48 6 are be VBP cord-302514-rstvf3mc 48 7 detected detect VBN cord-302514-rstvf3mc 48 8 in in IN cord-302514-rstvf3mc 48 9 60 60 CD cord-302514-rstvf3mc 48 10 % % NN cord-302514-rstvf3mc 48 11 of of IN cord-302514-rstvf3mc 48 12 primary primary JJ cord-302514-rstvf3mc 48 13 breast breast NN cord-302514-rstvf3mc 48 14 tumors tumor NNS cord-302514-rstvf3mc 48 15 and and CC cord-302514-rstvf3mc 48 16 metastases metastasis NNS cord-302514-rstvf3mc 48 17 , , , cord-302514-rstvf3mc 48 18 but but CC cord-302514-rstvf3mc 48 19 not not RB cord-302514-rstvf3mc 48 20 in in IN cord-302514-rstvf3mc 48 21 normal normal JJ cord-302514-rstvf3mc 48 22 epithelium epithelium NN cord-302514-rstvf3mc 48 23 ( ( -LRB- cord-302514-rstvf3mc 48 24 Table table NN cord-302514-rstvf3mc 48 25 2 2 CD cord-302514-rstvf3mc 48 26 ) ) -RRB- cord-302514-rstvf3mc 48 27 . . . cord-302514-rstvf3mc 49 1 The the DT cord-302514-rstvf3mc 49 2 expression expression NN cord-302514-rstvf3mc 49 3 of of IN cord-302514-rstvf3mc 49 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 49 5 is be VBZ cord-302514-rstvf3mc 49 6 sufficient sufficient JJ cord-302514-rstvf3mc 49 7 to to TO cord-302514-rstvf3mc 49 8 stimulate stimulate VB cord-302514-rstvf3mc 49 9 the the DT cord-302514-rstvf3mc 49 10 formation formation NN cord-302514-rstvf3mc 49 11 of of IN cord-302514-rstvf3mc 49 12 filopodia filopodia NNS cord-302514-rstvf3mc 49 13 in in IN cord-302514-rstvf3mc 49 14 BT549 BT549 NNP cord-302514-rstvf3mc 49 15 human human JJ cord-302514-rstvf3mc 49 16 breast breast NN cord-302514-rstvf3mc 49 17 cancer cancer NN cord-302514-rstvf3mc 49 18 cells cell NNS cord-302514-rstvf3mc 49 19 and and CC cord-302514-rstvf3mc 49 20 non non JJ cord-302514-rstvf3mc 49 21 - - JJ cord-302514-rstvf3mc 49 22 transformed transformed JJ cord-302514-rstvf3mc 49 23 Rat2 Rat2 NNP cord-302514-rstvf3mc 49 24 cells cell NNS cord-302514-rstvf3mc 49 25 . . . cord-302514-rstvf3mc 50 1 Moreover moreover RB cord-302514-rstvf3mc 50 2 , , , cord-302514-rstvf3mc 50 3 its -PRON- PRP$ cord-302514-rstvf3mc 50 4 expression expression NN cord-302514-rstvf3mc 50 5 is be VBZ cord-302514-rstvf3mc 50 6 sufficient sufficient JJ cord-302514-rstvf3mc 50 7 to to TO cord-302514-rstvf3mc 50 8 activate activate VB cord-302514-rstvf3mc 50 9 Akt Akt NNP cord-302514-rstvf3mc 50 10 in in IN cord-302514-rstvf3mc 50 11 a a DT cord-302514-rstvf3mc 50 12 PI3K pi3k NN cord-302514-rstvf3mc 50 13 - - HYPH cord-302514-rstvf3mc 50 14 dependent dependent JJ cord-302514-rstvf3mc 50 15 fashion fashion NN cord-302514-rstvf3mc 50 16 , , , cord-302514-rstvf3mc 50 17 as as IN cord-302514-rstvf3mc 50 18 down down IN cord-302514-rstvf3mc 50 19 - - HYPH cord-302514-rstvf3mc 50 20 regulation regulation NN cord-302514-rstvf3mc 50 21 of of IN cord-302514-rstvf3mc 50 22 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 50 23 by by IN cord-302514-rstvf3mc 50 24 siRNA siRNA NNP cord-302514-rstvf3mc 50 25 reduces reduce VBZ cord-302514-rstvf3mc 50 26 Akt Akt NNP cord-302514-rstvf3mc 50 27 activity activity NN cord-302514-rstvf3mc 50 28 . . . cord-302514-rstvf3mc 51 1 In in IN cord-302514-rstvf3mc 51 2 breast breast NN cord-302514-rstvf3mc 51 3 cancer cancer NN cord-302514-rstvf3mc 51 4 cell cell NN cord-302514-rstvf3mc 51 5 line line NN cord-302514-rstvf3mc 51 6 BT549 BT549 NNP cord-302514-rstvf3mc 51 7 , , , cord-302514-rstvf3mc 51 8 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 51 9 expression expression NN cord-302514-rstvf3mc 51 10 stimulates stimulate VBZ cord-302514-rstvf3mc 51 11 cell cell NN cord-302514-rstvf3mc 51 12 migration migration NN cord-302514-rstvf3mc 51 13 and and CC cord-302514-rstvf3mc 51 14 invasion invasion NN cord-302514-rstvf3mc 51 15 in in IN cord-302514-rstvf3mc 51 16 a a DT cord-302514-rstvf3mc 51 17 largely largely RB cord-302514-rstvf3mc 51 18 PI3 pi3 NN cord-302514-rstvf3mc 51 19 K K NNP cord-302514-rstvf3mc 51 20 and and CC cord-302514-rstvf3mc 51 21 Akt Akt NNP cord-302514-rstvf3mc 51 22 - - HYPH cord-302514-rstvf3mc 51 23 dependent dependent JJ cord-302514-rstvf3mc 51 24 manner manner NN cord-302514-rstvf3mc 51 25 , , , cord-302514-rstvf3mc 51 26 suggesting suggest VBG cord-302514-rstvf3mc 51 27 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 51 28 regulates regulate VBZ cord-302514-rstvf3mc 51 29 oncogenesis oncogenesis NN cord-302514-rstvf3mc 51 30 through through IN cord-302514-rstvf3mc 51 31 Akt Akt NNP cord-302514-rstvf3mc 51 32 and and CC cord-302514-rstvf3mc 51 33 PI3K PI3K NNP cord-302514-rstvf3mc 51 34 - - HYPH cord-302514-rstvf3mc 51 35 dependent dependent JJ cord-302514-rstvf3mc 51 36 cytoskeleton cytoskeleton NN cord-302514-rstvf3mc 51 37 remodeling remodeling NN cord-302514-rstvf3mc 51 38 ( ( -LRB- cord-302514-rstvf3mc 51 39 27 27 CD cord-302514-rstvf3mc 51 40 ) ) -RRB- cord-302514-rstvf3mc 52 1 ( ( -LRB- cord-302514-rstvf3mc 52 2 28 28 CD cord-302514-rstvf3mc 52 3 ) ) -RRB- cord-302514-rstvf3mc 52 4 ( ( -LRB- cord-302514-rstvf3mc 52 5 29 29 CD cord-302514-rstvf3mc 52 6 ) ) -RRB- cord-302514-rstvf3mc 52 7 . . . cord-302514-rstvf3mc 53 1 In in IN cord-302514-rstvf3mc 53 2 fact fact NN cord-302514-rstvf3mc 53 3 , , , cord-302514-rstvf3mc 53 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 53 5 participates participate VBZ cord-302514-rstvf3mc 53 6 in in IN cord-302514-rstvf3mc 53 7 the the DT cord-302514-rstvf3mc 53 8 regulation regulation NN cord-302514-rstvf3mc 53 9 of of IN cord-302514-rstvf3mc 53 10 the the DT cord-302514-rstvf3mc 53 11 phospholipids phospholipid NNS cord-302514-rstvf3mc 53 12 signaling signal VBG cord-302514-rstvf3mc 53 13 pathway pathway NN cord-302514-rstvf3mc 53 14 ( ( -LRB- cord-302514-rstvf3mc 53 15 Figure figure NN cord-302514-rstvf3mc 53 16 4 4 CD cord-302514-rstvf3mc 53 17 ) ) -RRB- cord-302514-rstvf3mc 53 18 . . . cord-302514-rstvf3mc 54 1 Phosphatidylinositols phosphatidylinositol NNS cord-302514-rstvf3mc 54 2 are be VBP cord-302514-rstvf3mc 54 3 negatively negatively RB cord-302514-rstvf3mc 54 4 charged charge VBN cord-302514-rstvf3mc 54 5 membrane membrane NN cord-302514-rstvf3mc 54 6 bound bind VBN cord-302514-rstvf3mc 54 7 phospholipids phospholipid NNS cord-302514-rstvf3mc 54 8 that that WDT cord-302514-rstvf3mc 54 9 participate participate VBP cord-302514-rstvf3mc 54 10 in in IN cord-302514-rstvf3mc 54 11 the the DT cord-302514-rstvf3mc 54 12 pathways pathway NNS cord-302514-rstvf3mc 54 13 that that WDT cord-302514-rstvf3mc 54 14 regulate regulate VBP cord-302514-rstvf3mc 54 15 the the DT cord-302514-rstvf3mc 54 16 cell cell NN cord-302514-rstvf3mc 54 17 proliferation proliferation NN cord-302514-rstvf3mc 54 18 , , , cord-302514-rstvf3mc 54 19 survival survival NN cord-302514-rstvf3mc 54 20 , , , cord-302514-rstvf3mc 54 21 cytoskeleton cytoskeleton NN cord-302514-rstvf3mc 54 22 organization organization NN cord-302514-rstvf3mc 54 23 , , , cord-302514-rstvf3mc 54 24 vesicular vesicular JJ cord-302514-rstvf3mc 54 25 trafficking trafficking NN cord-302514-rstvf3mc 54 26 , , , cord-302514-rstvf3mc 54 27 and and CC cord-302514-rstvf3mc 54 28 oncogenesis oncogenesis NNP cord-302514-rstvf3mc 54 29 ( ( -LRB- cord-302514-rstvf3mc 54 30 30 30 CD cord-302514-rstvf3mc 54 31 , , , cord-302514-rstvf3mc 54 32 31 31 CD cord-302514-rstvf3mc 54 33 ) ) -RRB- cord-302514-rstvf3mc 54 34 . . . cord-302514-rstvf3mc 55 1 Phosphoinositols phosphoinositol NNS cord-302514-rstvf3mc 55 2 are be VBP cord-302514-rstvf3mc 55 3 composed compose VBN cord-302514-rstvf3mc 55 4 of of IN cord-302514-rstvf3mc 55 5 an an DT cord-302514-rstvf3mc 55 6 inositol inositol NN cord-302514-rstvf3mc 55 7 ring ring NN cord-302514-rstvf3mc 55 8 in in IN cord-302514-rstvf3mc 55 9 which which WDT cord-302514-rstvf3mc 55 10 one one NN cord-302514-rstvf3mc 55 11 or or CC cord-302514-rstvf3mc 55 12 more more JJR cord-302514-rstvf3mc 55 13 −OH −oh ADD cord-302514-rstvf3mc 55 14 groups group NNS cord-302514-rstvf3mc 55 15 at at IN cord-302514-rstvf3mc 55 16 the the DT cord-302514-rstvf3mc 55 17 3- 3- NNP cord-302514-rstvf3mc 55 18 , , , cord-302514-rstvf3mc 55 19 4- 4- CD cord-302514-rstvf3mc 55 20 , , , cord-302514-rstvf3mc 55 21 and and CC cord-302514-rstvf3mc 55 22 5-position 5-position CD cord-302514-rstvf3mc 55 23 of of IN cord-302514-rstvf3mc 55 24 inositol inositol NN cord-302514-rstvf3mc 55 25 ring ring NN cord-302514-rstvf3mc 55 26 are be VBP cord-302514-rstvf3mc 55 27 esterified esterify VBN cord-302514-rstvf3mc 55 28 with with IN cord-302514-rstvf3mc 55 29 a a DT cord-302514-rstvf3mc 55 30 phosphate phosphate NN cord-302514-rstvf3mc 55 31 group group NN cord-302514-rstvf3mc 55 32 in in IN cord-302514-rstvf3mc 55 33 all all DT cord-302514-rstvf3mc 55 34 possible possible JJ cord-302514-rstvf3mc 55 35 combinations combination NNS cord-302514-rstvf3mc 55 36 . . . cord-302514-rstvf3mc 56 1 Specific specific JJ cord-302514-rstvf3mc 56 2 kinase kinase NN cord-302514-rstvf3mc 56 3 families family NNS cord-302514-rstvf3mc 56 4 ( ( -LRB- cord-302514-rstvf3mc 56 5 PI3 PI3 NNP cord-302514-rstvf3mc 56 6 K K NNP cord-302514-rstvf3mc 56 7 , , , cord-302514-rstvf3mc 56 8 PI4 PI4 NNP cord-302514-rstvf3mc 56 9 K K NNP cord-302514-rstvf3mc 56 10 , , , cord-302514-rstvf3mc 56 11 and and CC cord-302514-rstvf3mc 56 12 PI5 PI5 NNP cord-302514-rstvf3mc 56 13 K K NNP cord-302514-rstvf3mc 56 14 ) ) -RRB- cord-302514-rstvf3mc 56 15 are be VBP cord-302514-rstvf3mc 56 16 responsible responsible JJ cord-302514-rstvf3mc 56 17 for for IN cord-302514-rstvf3mc 56 18 phosphorylation phosphorylation NN cord-302514-rstvf3mc 56 19 at at IN cord-302514-rstvf3mc 56 20 these these DT cord-302514-rstvf3mc 56 21 sites site NNS cord-302514-rstvf3mc 56 22 ( ( -LRB- cord-302514-rstvf3mc 56 23 32 32 CD cord-302514-rstvf3mc 56 24 , , , cord-302514-rstvf3mc 56 25 33 33 CD cord-302514-rstvf3mc 56 26 ) ) -RRB- cord-302514-rstvf3mc 56 27 . . . cord-302514-rstvf3mc 57 1 Overexpression Overexpression NNP cord-302514-rstvf3mc 57 2 of of IN cord-302514-rstvf3mc 57 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 57 4 protein protein NN cord-302514-rstvf3mc 57 5 up up RB cord-302514-rstvf3mc 57 6 - - HYPH cord-302514-rstvf3mc 57 7 regulates regulate VBZ cord-302514-rstvf3mc 57 8 overall overall JJ cord-302514-rstvf3mc 57 9 PI4 PI4 NNP cord-302514-rstvf3mc 57 10 K K NNP cord-302514-rstvf3mc 57 11 activity activity NN cord-302514-rstvf3mc 57 12 and and CC cord-302514-rstvf3mc 57 13 cellular cellular JJ cord-302514-rstvf3mc 57 14 phosphatidylinositol phosphatidylinositol NN cord-302514-rstvf3mc 57 15 4-phosphate 4-phosphate CD cord-302514-rstvf3mc 57 16 ( ( -LRB- cord-302514-rstvf3mc 57 17 PI4P pi4p NN cord-302514-rstvf3mc 57 18 ) ) -RRB- cord-302514-rstvf3mc 57 19 generation generation NN cord-302514-rstvf3mc 57 20 in in IN cord-302514-rstvf3mc 57 21 human human JJ cord-302514-rstvf3mc 57 22 cells cell NNS cord-302514-rstvf3mc 57 23 . . . cord-302514-rstvf3mc 58 1 Furthermore furthermore RB cord-302514-rstvf3mc 58 2 , , , cord-302514-rstvf3mc 58 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 58 4 directly directly RB cord-302514-rstvf3mc 58 5 interacts interact VBZ cord-302514-rstvf3mc 58 6 with with IN cord-302514-rstvf3mc 58 7 and and CC cord-302514-rstvf3mc 58 8 activates activate VBZ cord-302514-rstvf3mc 58 9 phosphatidylinositol-4 phosphatidylinositol-4 NNP cord-302514-rstvf3mc 58 10 kinase kinase NN cord-302514-rstvf3mc 58 11 III III NNP cord-302514-rstvf3mc 58 12 β β NN cord-302514-rstvf3mc 58 13 ( ( -LRB- cord-302514-rstvf3mc 58 14 a a DT cord-302514-rstvf3mc 58 15 subfamily subfamily NN cord-302514-rstvf3mc 58 16 of of IN cord-302514-rstvf3mc 58 17 PI4 PI4 NNP cord-302514-rstvf3mc 58 18 K K NNP cord-302514-rstvf3mc 58 19 ) ) -RRB- cord-302514-rstvf3mc 58 20 , , , cord-302514-rstvf3mc 58 21 an an DT cord-302514-rstvf3mc 58 22 enzyme enzyme NN cord-302514-rstvf3mc 58 23 that that WDT cord-302514-rstvf3mc 58 24 converts convert VBZ cord-302514-rstvf3mc 58 25 phosphatidylinositol phosphatidylinositol JJ cord-302514-rstvf3mc 58 26 to to IN cord-302514-rstvf3mc 58 27 PI4P. PI4P. NNP cord-302514-rstvf3mc 58 28 Knockdown Knockdown NNP cord-302514-rstvf3mc 58 29 of of IN cord-302514-rstvf3mc 58 30 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 58 31 using use VBG cord-302514-rstvf3mc 58 32 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 58 33 siRNA siRNA NNP cord-302514-rstvf3mc 58 34 results result NNS cord-302514-rstvf3mc 58 35 in in IN cord-302514-rstvf3mc 58 36 downregulation downregulation NN cord-302514-rstvf3mc 58 37 of of IN cord-302514-rstvf3mc 58 38 phosphatidylinositol-4-kinase phosphatidylinositol-4-kinase NN cord-302514-rstvf3mc 58 39 activity activity NN cord-302514-rstvf3mc 58 40 indicating indicate VBG cord-302514-rstvf3mc 58 41 that that IN cord-302514-rstvf3mc 58 42 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 58 43 is be VBZ cord-302514-rstvf3mc 58 44 a a DT cord-302514-rstvf3mc 58 45 physiological physiological JJ cord-302514-rstvf3mc 58 46 regulator regulator NN cord-302514-rstvf3mc 58 47 of of IN cord-302514-rstvf3mc 58 48 PI4KIIIβ PI4KIIIβ NNP cord-302514-rstvf3mc 58 49 signaling signal VBG cord-302514-rstvf3mc 58 50 ( ( -LRB- cord-302514-rstvf3mc 58 51 34 34 CD cord-302514-rstvf3mc 58 52 , , , cord-302514-rstvf3mc 58 53 35 35 CD cord-302514-rstvf3mc 58 54 ) ) -RRB- cord-302514-rstvf3mc 58 55 . . . cord-302514-rstvf3mc 59 1 In in IN cord-302514-rstvf3mc 59 2 addition addition NN cord-302514-rstvf3mc 59 3 , , , cord-302514-rstvf3mc 59 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 59 5 expression expression NN cord-302514-rstvf3mc 59 6 up up RB cord-302514-rstvf3mc 59 7 - - : cord-302514-rstvf3mc 59 8 regulates regulate VBZ cord-302514-rstvf3mc 59 9 the the DT cord-302514-rstvf3mc 59 10 generation generation NN cord-302514-rstvf3mc 59 11 of of IN cord-302514-rstvf3mc 59 12 phosphatidylinositol-4,5-bisphosphate phosphatidylinositol-4,5-bisphosphate NN cord-302514-rstvf3mc 59 13 [ [ -LRB- cord-302514-rstvf3mc 59 14 PI(4,5)P2 PI(4,5)P2 NNP cord-302514-rstvf3mc 59 15 ] ] -RRB- cord-302514-rstvf3mc 59 16 in in IN cord-302514-rstvf3mc 59 17 the the DT cord-302514-rstvf3mc 59 18 cytoplasm cytoplasm NN cord-302514-rstvf3mc 59 19 and and CC cord-302514-rstvf3mc 59 20 at at IN cord-302514-rstvf3mc 59 21 the the DT cord-302514-rstvf3mc 59 22 plasma plasma NN cord-302514-rstvf3mc 59 23 membrane membrane NN cord-302514-rstvf3mc 59 24 . . . cord-302514-rstvf3mc 60 1 The the DT cord-302514-rstvf3mc 60 2 subsequent subsequent JJ cord-302514-rstvf3mc 60 3 increase increase NN cord-302514-rstvf3mc 60 4 in in IN cord-302514-rstvf3mc 60 5 PI(4,5)P2 PI(4,5)P2 NNP cord-302514-rstvf3mc 60 6 at at IN cord-302514-rstvf3mc 60 7 the the DT cord-302514-rstvf3mc 60 8 plasma plasma NN cord-302514-rstvf3mc 60 9 membrane membrane NN cord-302514-rstvf3mc 60 10 stimulates stimulate VBZ cord-302514-rstvf3mc 60 11 the the DT cord-302514-rstvf3mc 60 12 eEF1A2-induced eEF1A2-induced NNP cord-302514-rstvf3mc 60 13 filopodia filopodia NNS cord-302514-rstvf3mc 60 14 formation formation NN cord-302514-rstvf3mc 60 15 through through IN cord-302514-rstvf3mc 60 16 binding binding NN cord-302514-rstvf3mc 60 17 and and CC cord-302514-rstvf3mc 60 18 activation activation NN cord-302514-rstvf3mc 60 19 of of IN cord-302514-rstvf3mc 60 20 PI4KIII PI4KIII NNP cord-302514-rstvf3mc 60 21 β β NN cord-302514-rstvf3mc 60 22 . . . cord-302514-rstvf3mc 61 1 Therefore therefore RB cord-302514-rstvf3mc 61 2 , , , cord-302514-rstvf3mc 61 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 61 4 is be VBZ cord-302514-rstvf3mc 61 5 involved involve VBN cord-302514-rstvf3mc 61 6 in in IN cord-302514-rstvf3mc 61 7 phosphatidylinositol phosphatidylinositol JJ cord-302514-rstvf3mc 61 8 signaling signal VBG cord-302514-rstvf3mc 61 9 and and CC cord-302514-rstvf3mc 61 10 actin actin NN cord-302514-rstvf3mc 61 11 remodeling remodeling NN cord-302514-rstvf3mc 61 12 ( ( -LRB- cord-302514-rstvf3mc 61 13 34 34 CD cord-302514-rstvf3mc 61 14 , , , cord-302514-rstvf3mc 61 15 36 36 CD cord-302514-rstvf3mc 61 16 ) ) -RRB- cord-302514-rstvf3mc 61 17 . . . cord-302514-rstvf3mc 62 1 Moreover moreover RB cord-302514-rstvf3mc 62 2 , , , cord-302514-rstvf3mc 62 3 the the DT cord-302514-rstvf3mc 62 4 gene gene NN cord-302514-rstvf3mc 62 5 expression expression NN cord-302514-rstvf3mc 62 6 profiling profiling NN cord-302514-rstvf3mc 62 7 of of IN cord-302514-rstvf3mc 62 8 primary primary JJ cord-302514-rstvf3mc 62 9 mouse mouse NN cord-302514-rstvf3mc 62 10 B B NNP cord-302514-rstvf3mc 62 11 cell cell NN cord-302514-rstvf3mc 62 12 lineage lineage NN cord-302514-rstvf3mc 62 13 showed show VBD cord-302514-rstvf3mc 62 14 the the DT cord-302514-rstvf3mc 62 15 high high JJ cord-302514-rstvf3mc 62 16 expression expression NN cord-302514-rstvf3mc 62 17 of of IN cord-302514-rstvf3mc 62 18 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 62 19 in in IN cord-302514-rstvf3mc 62 20 plasmacytomas plasmacytomas NNP cord-302514-rstvf3mc 62 21 ( ( -LRB- cord-302514-rstvf3mc 62 22 PCT PCT NNP cord-302514-rstvf3mc 62 23 ) ) -RRB- cord-302514-rstvf3mc 62 24 , , , cord-302514-rstvf3mc 62 25 which which WDT cord-302514-rstvf3mc 62 26 results result VBZ cord-302514-rstvf3mc 62 27 in in IN cord-302514-rstvf3mc 62 28 progression progression NN cord-302514-rstvf3mc 62 29 Frontiers Frontiers NNP cord-302514-rstvf3mc 62 30 in in IN cord-302514-rstvf3mc 62 31 Oncology Oncology NNP cord-302514-rstvf3mc 62 32 | | NNP cord-302514-rstvf3mc 62 33 Molecular Molecular NNP cord-302514-rstvf3mc 62 34 and and CC cord-302514-rstvf3mc 62 35 Cellular Cellular NNP cord-302514-rstvf3mc 62 36 Oncology Oncology NNP cord-302514-rstvf3mc 62 37 _SP cord-302514-rstvf3mc 63 1 Transcription transcription NN cord-302514-rstvf3mc 63 2 start start NN cord-302514-rstvf3mc 63 3 site site NN cord-302514-rstvf3mc 63 4 +1 +1 NNS cord-302514-rstvf3mc 63 5 of of IN cord-302514-rstvf3mc 63 6 plasma plasma NN cord-302514-rstvf3mc 63 7 cell cell NN cord-302514-rstvf3mc 63 8 neoplasms neoplasm NNS cord-302514-rstvf3mc 63 9 in in IN cord-302514-rstvf3mc 63 10 both both DT cord-302514-rstvf3mc 63 11 mouse mouse NN cord-302514-rstvf3mc 63 12 and and CC cord-302514-rstvf3mc 63 13 human human NN cord-302514-rstvf3mc 63 14 ( ( -LRB- cord-302514-rstvf3mc 63 15 29 29 CD cord-302514-rstvf3mc 63 16 ) ) -RRB- cord-302514-rstvf3mc 63 17 . . . cord-302514-rstvf3mc 64 1 Finally finally RB cord-302514-rstvf3mc 64 2 , , , cord-302514-rstvf3mc 64 3 the the DT cord-302514-rstvf3mc 64 4 knockdown knockdown NN cord-302514-rstvf3mc 64 5 of of IN cord-302514-rstvf3mc 64 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 64 7 expression expression NN cord-302514-rstvf3mc 64 8 delays delay NNS cord-302514-rstvf3mc 64 9 or or CC cord-302514-rstvf3mc 64 10 impairs impair VBZ cord-302514-rstvf3mc 64 11 the the DT cord-302514-rstvf3mc 64 12 IL-6induced il-6induced JJ cord-302514-rstvf3mc 64 13 activation activation NN cord-302514-rstvf3mc 64 14 of of IN cord-302514-rstvf3mc 64 15 STAT3 STAT3 NNP cord-302514-rstvf3mc 64 16 and and CC cord-302514-rstvf3mc 64 17 Akt Akt NNP cord-302514-rstvf3mc 64 18 signaling signal VBG cord-302514-rstvf3mc 64 19 pathways pathway NNS cord-302514-rstvf3mc 64 20 suggesting suggest VBG cord-302514-rstvf3mc 64 21 that that DT cord-302514-rstvf3mc 64 22 activation activation NN cord-302514-rstvf3mc 64 23 of of IN cord-302514-rstvf3mc 64 24 STAT3 STAT3 NNP cord-302514-rstvf3mc 64 25 and and CC cord-302514-rstvf3mc 64 26 Akt Akt NNP cord-302514-rstvf3mc 64 27 through through IN cord-302514-rstvf3mc 64 28 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 64 29 involvement involvement NN cord-302514-rstvf3mc 64 30 that that WDT cord-302514-rstvf3mc 64 31 favors favor VBZ cord-302514-rstvf3mc 64 32 cell cell NN cord-302514-rstvf3mc 64 33 proliferation proliferation NN cord-302514-rstvf3mc 64 34 , , , cord-302514-rstvf3mc 64 35 cell cell NN cord-302514-rstvf3mc 64 36 cycle cycle NN cord-302514-rstvf3mc 64 37 progression progression NN cord-302514-rstvf3mc 64 38 , , , cord-302514-rstvf3mc 64 39 and and CC cord-302514-rstvf3mc 64 40 inhibition inhibition NN cord-302514-rstvf3mc 64 41 of of IN cord-302514-rstvf3mc 64 42 apoptosis apoptosis NN cord-302514-rstvf3mc 64 43 ( ( -LRB- cord-302514-rstvf3mc 64 44 29 29 CD cord-302514-rstvf3mc 64 45 , , , cord-302514-rstvf3mc 64 46 37 37 CD cord-302514-rstvf3mc 64 47 , , , cord-302514-rstvf3mc 64 48 38 38 CD cord-302514-rstvf3mc 64 49 ) ) -RRB- cord-302514-rstvf3mc 64 50 . . . cord-302514-rstvf3mc 65 1 Altogether altogether RB cord-302514-rstvf3mc 65 2 , , , cord-302514-rstvf3mc 65 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 65 4 protein protein NN cord-302514-rstvf3mc 65 5 activates activate VBZ cord-302514-rstvf3mc 65 6 the the DT cord-302514-rstvf3mc 65 7 PIK PIK NNP cord-302514-rstvf3mc 65 8 - - HYPH cord-302514-rstvf3mc 65 9 Akt Akt NNP cord-302514-rstvf3mc 65 10 - - HYPH cord-302514-rstvf3mc 65 11 STAT3 STAT3 NNP cord-302514-rstvf3mc 65 12 pathways pathway NNS cord-302514-rstvf3mc 65 13 that that WDT cord-302514-rstvf3mc 65 14 have have VBP cord-302514-rstvf3mc 65 15 been be VBN cord-302514-rstvf3mc 65 16 extensively extensively RB cord-302514-rstvf3mc 65 17 shown show VBN cord-302514-rstvf3mc 65 18 to to TO cord-302514-rstvf3mc 65 19 favor favor VB cord-302514-rstvf3mc 65 20 cellular cellular JJ cord-302514-rstvf3mc 65 21 transformation transformation NN cord-302514-rstvf3mc 65 22 and and CC cord-302514-rstvf3mc 65 23 oncogenesis oncogenesis NNP cord-302514-rstvf3mc 65 24 ( ( -LRB- cord-302514-rstvf3mc 65 25 39 39 CD cord-302514-rstvf3mc 65 26 ) ) -RRB- cord-302514-rstvf3mc 66 1 ( ( -LRB- cord-302514-rstvf3mc 66 2 40 40 CD cord-302514-rstvf3mc 66 3 ) ) -RRB- cord-302514-rstvf3mc 66 4 ( ( -LRB- cord-302514-rstvf3mc 66 5 41 41 CD cord-302514-rstvf3mc 66 6 ) ) -RRB- cord-302514-rstvf3mc 66 7 ( ( -LRB- cord-302514-rstvf3mc 66 8 42 42 CD cord-302514-rstvf3mc 66 9 ) ) -RRB- cord-302514-rstvf3mc 66 10 ( ( -LRB- cord-302514-rstvf3mc 66 11 43 43 CD cord-302514-rstvf3mc 66 12 ) ) -RRB- cord-302514-rstvf3mc 66 13 ( ( -LRB- cord-302514-rstvf3mc 66 14 44 44 CD cord-302514-rstvf3mc 66 15 ) ) -RRB- cord-302514-rstvf3mc 67 1 ( ( -LRB- cord-302514-rstvf3mc 67 2 Figure figure NN cord-302514-rstvf3mc 67 3 4 4 CD cord-302514-rstvf3mc 67 4 ) ) -RRB- cord-302514-rstvf3mc 67 5 . . . cord-302514-rstvf3mc 68 1 In in IN cord-302514-rstvf3mc 68 2 breast breast NN cord-302514-rstvf3mc 68 3 cancer cancer NN cord-302514-rstvf3mc 68 4 , , , cord-302514-rstvf3mc 68 5 the the DT cord-302514-rstvf3mc 68 6 genes gene NNS cord-302514-rstvf3mc 68 7 in in IN cord-302514-rstvf3mc 68 8 20q13 20q13 CD cord-302514-rstvf3mc 68 9 are be VBP cord-302514-rstvf3mc 68 10 frequently frequently RB cord-302514-rstvf3mc 68 11 amplified amplify VBN cord-302514-rstvf3mc 68 12 and and CC cord-302514-rstvf3mc 68 13 have have VBP cord-302514-rstvf3mc 68 14 been be VBN cord-302514-rstvf3mc 68 15 shown show VBN cord-302514-rstvf3mc 68 16 by by IN cord-302514-rstvf3mc 68 17 using use VBG cord-302514-rstvf3mc 68 18 comparative comparative JJ cord-302514-rstvf3mc 68 19 genomic genomic JJ cord-302514-rstvf3mc 68 20 hybridization hybridization NN cord-302514-rstvf3mc 68 21 and and CC cord-302514-rstvf3mc 68 22 fluorescence fluorescence NN cord-302514-rstvf3mc 68 23 in in IN cord-302514-rstvf3mc 68 24 situ situ NN cord-302514-rstvf3mc 68 25 hybridization hybridization NN cord-302514-rstvf3mc 68 26 ( ( -LRB- cord-302514-rstvf3mc 68 27 45 45 CD cord-302514-rstvf3mc 68 28 ) ) -RRB- cord-302514-rstvf3mc 68 29 . . . cord-302514-rstvf3mc 69 1 The the DT cord-302514-rstvf3mc 69 2 differential differential JJ cord-302514-rstvf3mc 69 3 screening screening NN cord-302514-rstvf3mc 69 4 of of IN cord-302514-rstvf3mc 69 5 cDNA cdna NN cord-302514-rstvf3mc 69 6 libraries library NNS cord-302514-rstvf3mc 69 7 from from IN cord-302514-rstvf3mc 69 8 metastatic metastatic JJ cord-302514-rstvf3mc 69 9 and and CC cord-302514-rstvf3mc 69 10 non non JJ cord-302514-rstvf3mc 69 11 - - JJ cord-302514-rstvf3mc 69 12 metastatic metastatic JJ cord-302514-rstvf3mc 69 13 cell cell NN cord-302514-rstvf3mc 69 14 lines line NNS cord-302514-rstvf3mc 69 15 derived derive VBN cord-302514-rstvf3mc 69 16 from from IN cord-302514-rstvf3mc 69 17 the the DT cord-302514-rstvf3mc 69 18 same same JJ cord-302514-rstvf3mc 69 19 parental parental JJ cord-302514-rstvf3mc 69 20 rat rat NN cord-302514-rstvf3mc 69 21 mammary mammary JJ cord-302514-rstvf3mc 69 22 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 69 23 showed show VBD cord-302514-rstvf3mc 69 24 a a DT cord-302514-rstvf3mc 69 25 1.5-fold 1.5-fold CD cord-302514-rstvf3mc 69 26 overexpression overexpression NN cord-302514-rstvf3mc 69 27 of of IN cord-302514-rstvf3mc 69 28 eEF1A eef1a CD cord-302514-rstvf3mc 69 29 in in IN cord-302514-rstvf3mc 69 30 the the DT cord-302514-rstvf3mc 69 31 metastatic metastatic NN cord-302514-rstvf3mc 69 32 compared compare VBN cord-302514-rstvf3mc 69 33 to to IN cord-302514-rstvf3mc 69 34 the the DT cord-302514-rstvf3mc 69 35 non non JJ cord-302514-rstvf3mc 69 36 - - JJ cord-302514-rstvf3mc 69 37 metastatic metastatic JJ cord-302514-rstvf3mc 69 38 cells cell NNS cord-302514-rstvf3mc 69 39 ( ( -LRB- cord-302514-rstvf3mc 69 40 46 46 CD cord-302514-rstvf3mc 69 41 ) ) -RRB- cord-302514-rstvf3mc 69 42 . . . cord-302514-rstvf3mc 70 1 Studying study VBG cord-302514-rstvf3mc 70 2 cancer cancer NN cord-302514-rstvf3mc 70 3 cell cell NN cord-302514-rstvf3mc 70 4 lines line NNS cord-302514-rstvf3mc 70 5 derived derive VBN cord-302514-rstvf3mc 70 6 from from IN cord-302514-rstvf3mc 70 7 breast breast NN cord-302514-rstvf3mc 70 8 , , , cord-302514-rstvf3mc 70 9 lung lung NN cord-302514-rstvf3mc 70 10 , , , cord-302514-rstvf3mc 70 11 prostate prostate NN cord-302514-rstvf3mc 70 12 , , , cord-302514-rstvf3mc 70 13 and and CC cord-302514-rstvf3mc 70 14 skin skin NN cord-302514-rstvf3mc 70 15 , , , cord-302514-rstvf3mc 70 16 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 70 17 gene gene NN cord-302514-rstvf3mc 70 18 expression expression NN cord-302514-rstvf3mc 70 19 exhibited exhibit VBD cord-302514-rstvf3mc 70 20 the the DT cord-302514-rstvf3mc 70 21 highest high JJS cord-302514-rstvf3mc 70 22 alteration alteration NN cord-302514-rstvf3mc 70 23 in in IN cord-302514-rstvf3mc 70 24 the the DT cord-302514-rstvf3mc 70 25 cancer cancer NN cord-302514-rstvf3mc 70 26 cell cell NN cord-302514-rstvf3mc 70 27 lines line NNS cord-302514-rstvf3mc 70 28 compared compare VBN cord-302514-rstvf3mc 70 29 to to IN cord-302514-rstvf3mc 70 30 normal normal JJ cord-302514-rstvf3mc 70 31 controls control NNS cord-302514-rstvf3mc 70 32 using use VBG cord-302514-rstvf3mc 70 33 a a DT cord-302514-rstvf3mc 70 34 profiling profiling NN cord-302514-rstvf3mc 70 35 array array NN cord-302514-rstvf3mc 70 36 ( ( -LRB- cord-302514-rstvf3mc 70 37 47 47 CD cord-302514-rstvf3mc 70 38 ) ) -RRB- cord-302514-rstvf3mc 70 39 ( ( -LRB- cord-302514-rstvf3mc 70 40 48 48 CD cord-302514-rstvf3mc 70 41 ) ) -RRB- cord-302514-rstvf3mc 70 42 ( ( -LRB- cord-302514-rstvf3mc 70 43 49 49 CD cord-302514-rstvf3mc 70 44 ) ) -RRB- cord-302514-rstvf3mc 70 45 ( ( -LRB- cord-302514-rstvf3mc 70 46 50 50 CD cord-302514-rstvf3mc 70 47 ) ) -RRB- cord-302514-rstvf3mc 70 48 . . . cord-302514-rstvf3mc 71 1 Ovarian ovarian JJ cord-302514-rstvf3mc 71 2 cancer cancer NN cord-302514-rstvf3mc 71 3 represents represent VBZ cord-302514-rstvf3mc 71 4 4 4 CD cord-302514-rstvf3mc 71 5 % % NN cord-302514-rstvf3mc 71 6 of of IN cord-302514-rstvf3mc 71 7 all all DT cord-302514-rstvf3mc 71 8 female female JJ cord-302514-rstvf3mc 71 9 cancer cancer NN cord-302514-rstvf3mc 71 10 . . . cord-302514-rstvf3mc 72 1 It -PRON- PRP cord-302514-rstvf3mc 72 2 has have VBZ cord-302514-rstvf3mc 72 3 the the DT cord-302514-rstvf3mc 72 4 highest high JJS cord-302514-rstvf3mc 72 5 fatality fatality NN cord-302514-rstvf3mc 72 6 to to TO cord-302514-rstvf3mc 72 7 case case NN cord-302514-rstvf3mc 72 8 ratio ratio NN cord-302514-rstvf3mc 72 9 of of IN cord-302514-rstvf3mc 72 10 all all DT cord-302514-rstvf3mc 72 11 gynecological gynecological JJ cord-302514-rstvf3mc 72 12 cancers cancer NNS cord-302514-rstvf3mc 72 13 because because IN cord-302514-rstvf3mc 72 14 the the DT cord-302514-rstvf3mc 72 15 majority majority NN cord-302514-rstvf3mc 72 16 of of IN cord-302514-rstvf3mc 72 17 cases case NNS cord-302514-rstvf3mc 72 18 are be VBP cord-302514-rstvf3mc 72 19 diagnosed diagnose VBN cord-302514-rstvf3mc 72 20 in in IN cord-302514-rstvf3mc 72 21 the the DT cord-302514-rstvf3mc 72 22 late late JJ cord-302514-rstvf3mc 72 23 stage stage NN cord-302514-rstvf3mc 72 24 . . . cord-302514-rstvf3mc 73 1 Despite despite IN cord-302514-rstvf3mc 73 2 of of IN cord-302514-rstvf3mc 73 3 significant significant JJ cord-302514-rstvf3mc 73 4 efforts effort NNS cord-302514-rstvf3mc 73 5 to to TO cord-302514-rstvf3mc 73 6 improve improve VB cord-302514-rstvf3mc 73 7 the the DT cord-302514-rstvf3mc 73 8 early early JJ cord-302514-rstvf3mc 73 9 detection detection NN cord-302514-rstvf3mc 73 10 and and CC cord-302514-rstvf3mc 73 11 advances advance NNS cord-302514-rstvf3mc 73 12 www.frontiersin.org www.frontiersin.org IN cord-302514-rstvf3mc 73 13 _SP cord-302514-rstvf3mc 73 14 Cell Cell NNP cord-302514-rstvf3mc 73 15 proliferation proliferation NN cord-302514-rstvf3mc 73 16 Apoptosis apoptosis NN cord-302514-rstvf3mc 73 17 inhibition inhibition NN cord-302514-rstvf3mc 73 18 Cell cell NN cord-302514-rstvf3mc 73 19 survival survival NN cord-302514-rstvf3mc 74 1 JAK JAK NNP cord-302514-rstvf3mc 74 2 / / SYM cord-302514-rstvf3mc 74 3 STAT STAT NNP cord-302514-rstvf3mc 74 4 FIGURE figure NN cord-302514-rstvf3mc 75 1 4 4 LS cord-302514-rstvf3mc 75 2 | | NNP cord-302514-rstvf3mc 75 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 75 4 activates activate VBZ cord-302514-rstvf3mc 75 5 the the DT cord-302514-rstvf3mc 75 6 phospholipid phospholipid NN cord-302514-rstvf3mc 75 7 , , , cord-302514-rstvf3mc 75 8 JAK JAK NNP cord-302514-rstvf3mc 75 9 / / SYM cord-302514-rstvf3mc 75 10 STAT STAT NNP cord-302514-rstvf3mc 75 11 , , , cord-302514-rstvf3mc 75 12 and and CC cord-302514-rstvf3mc 75 13 Akt Akt NNP cord-302514-rstvf3mc 75 14 pathways pathway NNS cord-302514-rstvf3mc 75 15 . . . cord-302514-rstvf3mc 76 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 76 2 is be VBZ cord-302514-rstvf3mc 76 3 a a DT cord-302514-rstvf3mc 76 4 physiological physiological JJ cord-302514-rstvf3mc 76 5 regulator regulator NN cord-302514-rstvf3mc 76 6 of of IN cord-302514-rstvf3mc 76 7 phosphatidylinositol-4-kinase phosphatidylinositol-4-kinase NN cord-302514-rstvf3mc 76 8 ( ( -LRB- cord-302514-rstvf3mc 76 9 PI4 PI4 NNP cord-302514-rstvf3mc 76 10 K K NNP cord-302514-rstvf3mc 76 11 ) ) -RRB- cord-302514-rstvf3mc 76 12 . . . cord-302514-rstvf3mc 77 1 It -PRON- PRP cord-302514-rstvf3mc 77 2 directly directly RB cord-302514-rstvf3mc 77 3 interacts interact VBZ cord-302514-rstvf3mc 77 4 with with IN cord-302514-rstvf3mc 77 5 phosphatidyloinositol-4 phosphatidyloinositol-4 NNP cord-302514-rstvf3mc 77 6 kinase kinase NN cord-302514-rstvf3mc 77 7 III III NNP cord-302514-rstvf3mc 77 8 β β NN cord-302514-rstvf3mc 77 9 ( ( -LRB- cord-302514-rstvf3mc 77 10 PI4KIIIβ PI4KIIIβ NNP cord-302514-rstvf3mc 77 11 ) ) -RRB- cord-302514-rstvf3mc 77 12 and and CC cord-302514-rstvf3mc 77 13 enhances enhance VBZ cord-302514-rstvf3mc 77 14 its -PRON- PRP$ cord-302514-rstvf3mc 77 15 lipid lipid NN cord-302514-rstvf3mc 77 16 kinase kinase NN cord-302514-rstvf3mc 77 17 activity activity NN cord-302514-rstvf3mc 77 18 by by IN cord-302514-rstvf3mc 77 19 converting convert VBG cord-302514-rstvf3mc 77 20 the the DT cord-302514-rstvf3mc 77 21 phosphatidylinositol phosphatidylinositol NN cord-302514-rstvf3mc 77 22 ( ( -LRB- cord-302514-rstvf3mc 77 23 PtdIns PtdIns NNP cord-302514-rstvf3mc 77 24 ) ) -RRB- cord-302514-rstvf3mc 77 25 into into IN cord-302514-rstvf3mc 77 26 phosphatidylinositol-4-phosphate phosphatidylinositol-4-phosphate NNP cord-302514-rstvf3mc 77 27 ( ( -LRB- cord-302514-rstvf3mc 77 28 PtdIns4P PtdIns4P NNP cord-302514-rstvf3mc 77 29 ) ) -RRB- cord-302514-rstvf3mc 77 30 . . . cord-302514-rstvf3mc 78 1 Then then RB cord-302514-rstvf3mc 78 2 PI4KIIIβ PI4KIIIβ NNP cord-302514-rstvf3mc 78 3 and and CC cord-302514-rstvf3mc 78 4 PtdIns4P PtdIns4P NNS cord-302514-rstvf3mc 78 5 increase increase VB cord-302514-rstvf3mc 78 6 the the DT cord-302514-rstvf3mc 78 7 phosphatidylinositol-4,5 phosphatidylinositol-4,5 JJ cord-302514-rstvf3mc 78 8 bisphosphate bisphosphate NN cord-302514-rstvf3mc 78 9 generation generation NN cord-302514-rstvf3mc 78 10 at at IN cord-302514-rstvf3mc 78 11 the the DT cord-302514-rstvf3mc 78 12 plasma plasma NN cord-302514-rstvf3mc 78 13 membrane membrane NN cord-302514-rstvf3mc 78 14 level level NN cord-302514-rstvf3mc 78 15 , , , cord-302514-rstvf3mc 78 16 which which WDT cord-302514-rstvf3mc 78 17 results result VBZ cord-302514-rstvf3mc 78 18 in in IN cord-302514-rstvf3mc 78 19 the the DT cord-302514-rstvf3mc 78 20 filopodia filopodia NNS cord-302514-rstvf3mc 78 21 formation formation NN cord-302514-rstvf3mc 78 22 and and CC cord-302514-rstvf3mc 78 23 actin actin NN cord-302514-rstvf3mc 78 24 remodeling remodeling NN cord-302514-rstvf3mc 78 25 . . . cord-302514-rstvf3mc 79 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 79 2 also also RB cord-302514-rstvf3mc 79 3 directly directly RB cord-302514-rstvf3mc 79 4 or or CC cord-302514-rstvf3mc 79 5 indirectly indirectly RB cord-302514-rstvf3mc 79 6 regulates regulate VBZ cord-302514-rstvf3mc 80 1 the the DT cord-302514-rstvf3mc 80 2 JAK JAK NNP cord-302514-rstvf3mc 80 3 / / SYM cord-302514-rstvf3mc 80 4 STAT STAT NNP cord-302514-rstvf3mc 80 5 and and CC cord-302514-rstvf3mc 80 6 Akt Akt NNP cord-302514-rstvf3mc 80 7 signaling signal VBG cord-302514-rstvf3mc 80 8 pathways pathway NNS cord-302514-rstvf3mc 80 9 . . . cord-302514-rstvf3mc 81 1 in in IN cord-302514-rstvf3mc 81 2 chemotherapy chemotherapy NN cord-302514-rstvf3mc 81 3 , , , cord-302514-rstvf3mc 81 4 metastasis metastasis NN cord-302514-rstvf3mc 81 5 remains remain VBZ cord-302514-rstvf3mc 81 6 a a DT cord-302514-rstvf3mc 81 7 major major JJ cord-302514-rstvf3mc 81 8 challenge challenge NN cord-302514-rstvf3mc 81 9 in in IN cord-302514-rstvf3mc 81 10 clinical clinical JJ cord-302514-rstvf3mc 81 11 management management NN cord-302514-rstvf3mc 81 12 of of IN cord-302514-rstvf3mc 81 13 ovarian ovarian JJ cord-302514-rstvf3mc 81 14 cancer cancer NN cord-302514-rstvf3mc 81 15 ( ( -LRB- cord-302514-rstvf3mc 81 16 51 51 CD cord-302514-rstvf3mc 81 17 ) ) -RRB- cord-302514-rstvf3mc 82 1 ( ( -LRB- cord-302514-rstvf3mc 82 2 52 52 CD cord-302514-rstvf3mc 82 3 ) ) -RRB- cord-302514-rstvf3mc 83 1 ( ( -LRB- cord-302514-rstvf3mc 83 2 53 53 CD cord-302514-rstvf3mc 83 3 ) ) -RRB- cord-302514-rstvf3mc 83 4 ( ( -LRB- cord-302514-rstvf3mc 83 5 54 54 CD cord-302514-rstvf3mc 83 6 ) ) -RRB- cord-302514-rstvf3mc 83 7 . . . cord-302514-rstvf3mc 84 1 The the DT cord-302514-rstvf3mc 84 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 84 3 gene gene NN cord-302514-rstvf3mc 84 4 is be VBZ cord-302514-rstvf3mc 84 5 not not RB cord-302514-rstvf3mc 84 6 expressed express VBN cord-302514-rstvf3mc 84 7 in in IN cord-302514-rstvf3mc 84 8 normal normal JJ cord-302514-rstvf3mc 84 9 ovary ovary NN cord-302514-rstvf3mc 84 10 but but CC cord-302514-rstvf3mc 84 11 highly highly RB cord-302514-rstvf3mc 84 12 expressed express VBN cord-302514-rstvf3mc 84 13 in in IN cord-302514-rstvf3mc 84 14 ovarian ovarian JJ cord-302514-rstvf3mc 84 15 cancer cancer NN cord-302514-rstvf3mc 84 16 ( ( -LRB- cord-302514-rstvf3mc 84 17 55 55 CD cord-302514-rstvf3mc 84 18 ) ) -RRB- cord-302514-rstvf3mc 84 19 . . . cord-302514-rstvf3mc 85 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 85 2 expression expression NN cord-302514-rstvf3mc 85 3 enhances enhance VBZ cord-302514-rstvf3mc 85 4 the the DT cord-302514-rstvf3mc 85 5 ovarian ovarian JJ cord-302514-rstvf3mc 85 6 cell cell NN cord-302514-rstvf3mc 85 7 growth growth NN cord-302514-rstvf3mc 85 8 in in IN cord-302514-rstvf3mc 85 9 vitro vitro FW cord-302514-rstvf3mc 85 10 and and CC cord-302514-rstvf3mc 85 11 favors favor VBZ cord-302514-rstvf3mc 85 12 the the DT cord-302514-rstvf3mc 85 13 tumorsphere tumorsphere NNP cord-302514-rstvf3mc 85 14 formation formation NN cord-302514-rstvf3mc 85 15 ( ( -LRB- cord-302514-rstvf3mc 85 16 56 56 CD cord-302514-rstvf3mc 85 17 ) ) -RRB- cord-302514-rstvf3mc 85 18 , , , cord-302514-rstvf3mc 85 19 suggesting suggest VBG cord-302514-rstvf3mc 85 20 that that IN cord-302514-rstvf3mc 85 21 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 85 22 could could MD cord-302514-rstvf3mc 85 23 favor favor VB cord-302514-rstvf3mc 85 24 the the DT cord-302514-rstvf3mc 85 25 development development NN cord-302514-rstvf3mc 85 26 of of IN cord-302514-rstvf3mc 85 27 ovarian ovarian JJ cord-302514-rstvf3mc 85 28 primary primary JJ cord-302514-rstvf3mc 85 29 tumor tumor NN cord-302514-rstvf3mc 85 30 formation formation NN cord-302514-rstvf3mc 85 31 . . . cord-302514-rstvf3mc 86 1 High high JJ cord-302514-rstvf3mc 86 2 levels level NNS cord-302514-rstvf3mc 86 3 of of IN cord-302514-rstvf3mc 86 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 86 5 expression expression NN cord-302514-rstvf3mc 86 6 was be VBD cord-302514-rstvf3mc 86 7 observed observe VBN cord-302514-rstvf3mc 86 8 in in IN cord-302514-rstvf3mc 86 9 30 30 CD cord-302514-rstvf3mc 86 10 % % NN cord-302514-rstvf3mc 86 11 all all PDT cord-302514-rstvf3mc 86 12 the the DT cord-302514-rstvf3mc 86 13 primary primary JJ cord-302514-rstvf3mc 86 14 ovarian ovarian JJ cord-302514-rstvf3mc 86 15 tumors tumor NNS cord-302514-rstvf3mc 86 16 , , , cord-302514-rstvf3mc 86 17 50 50 CD cord-302514-rstvf3mc 86 18 % % NN cord-302514-rstvf3mc 86 19 of of IN cord-302514-rstvf3mc 86 20 serous serous JJ cord-302514-rstvf3mc 86 21 tumors tumor NNS cord-302514-rstvf3mc 86 22 , , , cord-302514-rstvf3mc 86 23 30 30 CD cord-302514-rstvf3mc 86 24 % % NN cord-302514-rstvf3mc 86 25 of of IN cord-302514-rstvf3mc 86 26 endometrioid endometrioid NN cord-302514-rstvf3mc 86 27 tumors tumor NNS cord-302514-rstvf3mc 86 28 , , , cord-302514-rstvf3mc 86 29 19 19 CD cord-302514-rstvf3mc 86 30 % % NN cord-302514-rstvf3mc 86 31 of of IN cord-302514-rstvf3mc 86 32 mucinous mucinous JJ cord-302514-rstvf3mc 86 33 tumors tumor NNS cord-302514-rstvf3mc 86 34 , , , cord-302514-rstvf3mc 86 35 and and CC cord-302514-rstvf3mc 86 36 8 8 CD cord-302514-rstvf3mc 86 37 % % NN cord-302514-rstvf3mc 86 38 of of IN cord-302514-rstvf3mc 86 39 clear clear JJ cord-302514-rstvf3mc 86 40 - - HYPH cord-302514-rstvf3mc 86 41 cell cell NN cord-302514-rstvf3mc 86 42 tumors tumor NNS cord-302514-rstvf3mc 86 43 ( ( -LRB- cord-302514-rstvf3mc 86 44 Table table NN cord-302514-rstvf3mc 86 45 2 2 CD cord-302514-rstvf3mc 86 46 ) ) -RRB- cord-302514-rstvf3mc 86 47 ( ( -LRB- cord-302514-rstvf3mc 86 48 56 56 CD cord-302514-rstvf3mc 86 49 ) ) -RRB- cord-302514-rstvf3mc 86 50 . . . cord-302514-rstvf3mc 87 1 Furthermore furthermore RB cord-302514-rstvf3mc 87 2 , , , cord-302514-rstvf3mc 87 3 the the DT cord-302514-rstvf3mc 87 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 87 5 protein protein NN cord-302514-rstvf3mc 87 6 and and CC cord-302514-rstvf3mc 87 7 RNA RNA NNP cord-302514-rstvf3mc 87 8 expression expression NN cord-302514-rstvf3mc 87 9 levels level NNS cord-302514-rstvf3mc 87 10 are be VBP cord-302514-rstvf3mc 87 11 upregulated upregulate VBN cord-302514-rstvf3mc 87 12 in in IN cord-302514-rstvf3mc 87 13 clear clear JJ cord-302514-rstvf3mc 87 14 - - HYPH cord-302514-rstvf3mc 87 15 cell cell NN cord-302514-rstvf3mc 87 16 ovarian ovarian JJ cord-302514-rstvf3mc 87 17 carcinoma carcinoma NN cord-302514-rstvf3mc 87 18 by by IN cord-302514-rstvf3mc 87 19 75 75 CD cord-302514-rstvf3mc 87 20 and and CC cord-302514-rstvf3mc 87 21 33 33 CD cord-302514-rstvf3mc 87 22 % % NN cord-302514-rstvf3mc 87 23 respectively respectively RB cord-302514-rstvf3mc 87 24 . . . cord-302514-rstvf3mc 88 1 The the DT cord-302514-rstvf3mc 88 2 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 88 3 gene gene NN cord-302514-rstvf3mc 88 4 is be VBZ cord-302514-rstvf3mc 88 5 unmethylated unmethylate VBN cord-302514-rstvf3mc 88 6 both both DT cord-302514-rstvf3mc 88 7 in in IN cord-302514-rstvf3mc 88 8 normal normal JJ cord-302514-rstvf3mc 88 9 and and CC cord-302514-rstvf3mc 88 10 tumor tumor NN cord-302514-rstvf3mc 88 11 cells cell NNS cord-302514-rstvf3mc 88 12 , , , cord-302514-rstvf3mc 88 13 suggesting suggest VBG cord-302514-rstvf3mc 88 14 that that IN cord-302514-rstvf3mc 88 15 up up NN cord-302514-rstvf3mc 88 16 - - HYPH cord-302514-rstvf3mc 88 17 regulation regulation NN cord-302514-rstvf3mc 88 18 of of IN cord-302514-rstvf3mc 88 19 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 88 20 gene gene NN cord-302514-rstvf3mc 88 21 expression expression NN cord-302514-rstvf3mc 88 22 is be VBZ cord-302514-rstvf3mc 88 23 not not RB cord-302514-rstvf3mc 88 24 dependent dependent JJ cord-302514-rstvf3mc 88 25 on on IN cord-302514-rstvf3mc 88 26 epigenetic epigenetic JJ cord-302514-rstvf3mc 88 27 modifications modification NNS cord-302514-rstvf3mc 88 28 ( ( -LRB- cord-302514-rstvf3mc 88 29 at at IN cord-302514-rstvf3mc 88 30 least least JJS cord-302514-rstvf3mc 88 31 for for IN cord-302514-rstvf3mc 88 32 the the DT cord-302514-rstvf3mc 88 33 methylation methylation NN cord-302514-rstvf3mc 88 34 status status NN cord-302514-rstvf3mc 88 35 ) ) -RRB- cord-302514-rstvf3mc 88 36 , , , cord-302514-rstvf3mc 88 37 but but CC cord-302514-rstvf3mc 88 38 instead instead RB cord-302514-rstvf3mc 88 39 that that IN cord-302514-rstvf3mc 88 40 the the DT cord-302514-rstvf3mc 88 41 inappropriate inappropriate JJ cord-302514-rstvf3mc 88 42 expression expression NN cord-302514-rstvf3mc 88 43 of of IN cord-302514-rstvf3mc 88 44 trans trans NNP cord-302514-rstvf3mc 88 45 - - JJ cord-302514-rstvf3mc 88 46 acting act VBG cord-302514-rstvf3mc 88 47 factor(s factor(s NNP cord-302514-rstvf3mc 88 48 ) ) -RRB- cord-302514-rstvf3mc 88 49 could could MD cord-302514-rstvf3mc 88 50 be be VB cord-302514-rstvf3mc 88 51 involved involve VBN cord-302514-rstvf3mc 88 52 ( ( -LRB- cord-302514-rstvf3mc 88 53 55 55 CD cord-302514-rstvf3mc 88 54 ) ) -RRB- cord-302514-rstvf3mc 88 55 . . . cord-302514-rstvf3mc 89 1 The the DT cord-302514-rstvf3mc 89 2 enhanced enhanced JJ cord-302514-rstvf3mc 89 3 expression expression NN cord-302514-rstvf3mc 89 4 of of IN cord-302514-rstvf3mc 89 5 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 89 6 protein protein NN cord-302514-rstvf3mc 89 7 in in IN cord-302514-rstvf3mc 89 8 ovarian ovarian JJ cord-302514-rstvf3mc 89 9 cancers cancer NNS cord-302514-rstvf3mc 89 10 correlates correlate VBZ cord-302514-rstvf3mc 89 11 with with IN cord-302514-rstvf3mc 89 12 poor poor JJ cord-302514-rstvf3mc 89 13 prognosis prognosis NN cord-302514-rstvf3mc 89 14 ( ( -LRB- cord-302514-rstvf3mc 89 15 57 57 CD cord-302514-rstvf3mc 89 16 ) ) -RRB- cord-302514-rstvf3mc 89 17 . . . cord-302514-rstvf3mc 90 1 The the DT cord-302514-rstvf3mc 90 2 oncogenic oncogenic JJ cord-302514-rstvf3mc 90 3 properties property NNS cord-302514-rstvf3mc 90 4 of of IN cord-302514-rstvf3mc 90 5 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 90 6 have have VBP cord-302514-rstvf3mc 90 7 also also RB cord-302514-rstvf3mc 90 8 been be VBN cord-302514-rstvf3mc 90 9 studied study VBN cord-302514-rstvf3mc 90 10 in in IN cord-302514-rstvf3mc 90 11 different different JJ cord-302514-rstvf3mc 90 12 ovarian ovarian JJ cord-302514-rstvf3mc 90 13 tumors tumor NNS cord-302514-rstvf3mc 90 14 and and CC cord-302514-rstvf3mc 90 15 established establish VBD cord-302514-rstvf3mc 90 16 cell cell NN cord-302514-rstvf3mc 90 17 lines line NNS cord-302514-rstvf3mc 90 18 . . . cord-302514-rstvf3mc 91 1 In in IN cord-302514-rstvf3mc 91 2 rodent rodent NN cord-302514-rstvf3mc 91 3 fibroblasts fibroblast NNS cord-302514-rstvf3mc 91 4 , , , cord-302514-rstvf3mc 91 5 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 91 6 protein protein NN cord-302514-rstvf3mc 91 7 favors favor VBZ cord-302514-rstvf3mc 91 8 anchorage anchorage NNP cord-302514-rstvf3mc 91 9 - - HYPH cord-302514-rstvf3mc 91 10 independent independent JJ cord-302514-rstvf3mc 91 11 growth growth NN cord-302514-rstvf3mc 91 12 and and CC cord-302514-rstvf3mc 91 13 results result NNS cord-302514-rstvf3mc 91 14 in in IN cord-302514-rstvf3mc 91 15 decreased decrease VBN cord-302514-rstvf3mc 91 16 doubling double VBG cord-302514-rstvf3mc 91 17 time time NN cord-302514-rstvf3mc 91 18 during during IN cord-302514-rstvf3mc 91 19 cellular cellular JJ cord-302514-rstvf3mc 91 20 proliferation proliferation NN cord-302514-rstvf3mc 91 21 . . . cord-302514-rstvf3mc 92 1 Furthermore furthermore RB cord-302514-rstvf3mc 92 2 , , , cord-302514-rstvf3mc 92 3 the the DT cord-302514-rstvf3mc 92 4 induced induce VBN cord-302514-rstvf3mc 92 5 expression expression NN cord-302514-rstvf3mc 92 6 of of IN cord-302514-rstvf3mc 92 7 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 92 8 in in IN cord-302514-rstvf3mc 92 9 NIH3T3 NIH3T3 NNP cord-302514-rstvf3mc 92 10 cells cell NNS cord-302514-rstvf3mc 92 11 makes make VBZ cord-302514-rstvf3mc 92 12 them -PRON- PRP cord-302514-rstvf3mc 92 13 tumorigenic tumorigenic JJ cord-302514-rstvf3mc 92 14 and and CC cord-302514-rstvf3mc 92 15 increases increase VBZ cord-302514-rstvf3mc 92 16 the the DT cord-302514-rstvf3mc 92 17 growth growth NN cord-302514-rstvf3mc 92 18 rate rate NN cord-302514-rstvf3mc 92 19 of of IN cord-302514-rstvf3mc 92 20 ES-2 ES-2 NNP cord-302514-rstvf3mc 92 21 ovarian ovarian JJ cord-302514-rstvf3mc 92 22 carcinoma carcinoma NN cord-302514-rstvf3mc 92 23 cells cell NNS cord-302514-rstvf3mc 92 24 xenografted xenografte VBN cord-302514-rstvf3mc 92 25 in in IN cord-302514-rstvf3mc 92 26 nude nude JJ cord-302514-rstvf3mc 92 27 mice mouse NNS cord-302514-rstvf3mc 92 28 ( ( -LRB- cord-302514-rstvf3mc 92 29 40 40 CD cord-302514-rstvf3mc 92 30 ) ) -RRB- cord-302514-rstvf3mc 92 31 . . . cord-302514-rstvf3mc 93 1 The the DT cord-302514-rstvf3mc 93 2 transcription transcription NN cord-302514-rstvf3mc 93 3 factor factor NN cord-302514-rstvf3mc 93 4 ZNF217 ZNF217 NNP cord-302514-rstvf3mc 93 5 and and CC cord-302514-rstvf3mc 93 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 93 7 , , , cord-302514-rstvf3mc 93 8 both both DT cord-302514-rstvf3mc 93 9 located locate VBN cord-302514-rstvf3mc 93 10 on on IN cord-302514-rstvf3mc 93 11 chromosome chromosome NN cord-302514-rstvf3mc 93 12 20q13 20q13 CD cord-302514-rstvf3mc 93 13 , , , cord-302514-rstvf3mc 93 14 are be VBP cord-302514-rstvf3mc 93 15 frequently frequently RB cord-302514-rstvf3mc 93 16 amplified amplify VBN cord-302514-rstvf3mc 93 17 in in IN cord-302514-rstvf3mc 93 18 ovarian ovarian JJ cord-302514-rstvf3mc 93 19 epithelial epithelial JJ cord-302514-rstvf3mc 93 20 carcinomas carcinoma NNS cord-302514-rstvf3mc 93 21 . . . cord-302514-rstvf3mc 94 1 The the DT cord-302514-rstvf3mc 94 2 stable stable JJ cord-302514-rstvf3mc 94 3 preneoplastic preneoplastic JJ cord-302514-rstvf3mc 94 4 ovarian ovarian JJ cord-302514-rstvf3mc 94 5 cell cell NN cord-302514-rstvf3mc 94 6 lines line NNS cord-302514-rstvf3mc 94 7 that that WDT cord-302514-rstvf3mc 94 8 over over IN cord-302514-rstvf3mc 94 9 - - HYPH cord-302514-rstvf3mc 94 10 express express NN cord-302514-rstvf3mc 94 11 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 94 12 provides provide VBZ cord-302514-rstvf3mc 94 13 the the DT cord-302514-rstvf3mc 94 14 evidence evidence NN cord-302514-rstvf3mc 94 15 that that IN cord-302514-rstvf3mc 94 16 up up IN cord-302514-rstvf3mc 94 17 - - HYPH cord-302514-rstvf3mc 94 18 regulation regulation NN cord-302514-rstvf3mc 94 19 of of IN cord-302514-rstvf3mc 94 20 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 94 21 expression expression NN cord-302514-rstvf3mc 94 22 contributes contribute VBZ cord-302514-rstvf3mc 94 23 to to IN cord-302514-rstvf3mc 94 24 the the DT cord-302514-rstvf3mc 94 25 neoplastic neoplastic JJ cord-302514-rstvf3mc 94 26 properties property NNS cord-302514-rstvf3mc 94 27 of of IN cord-302514-rstvf3mc 94 28 precursor precursor NN cord-302514-rstvf3mc 94 29 cells cell NNS cord-302514-rstvf3mc 94 30 of of IN cord-302514-rstvf3mc 94 31 ovarian ovarian JJ cord-302514-rstvf3mc 94 32 carcinomas carcinoma NNS cord-302514-rstvf3mc 94 33 mediated mediate VBN cord-302514-rstvf3mc 94 34 through through IN cord-302514-rstvf3mc 94 35 ZNF217 ZNF217 NNP cord-302514-rstvf3mc 94 36 ( ( -LRB- cord-302514-rstvf3mc 94 37 58 58 CD cord-302514-rstvf3mc 94 38 ) ) -RRB- cord-302514-rstvf3mc 94 39 . . . cord-302514-rstvf3mc 95 1 Resveratrol Resveratrol NNP cord-302514-rstvf3mc 95 2 , , , cord-302514-rstvf3mc 95 3 a a DT cord-302514-rstvf3mc 95 4 phytoalexin phytoalexin NN cord-302514-rstvf3mc 95 5 produced produce VBN cord-302514-rstvf3mc 95 6 naturally naturally RB cord-302514-rstvf3mc 95 7 by by IN cord-302514-rstvf3mc 95 8 several several JJ cord-302514-rstvf3mc 95 9 fruit fruit NN cord-302514-rstvf3mc 95 10 plants plant NNS cord-302514-rstvf3mc 95 11 , , , cord-302514-rstvf3mc 95 12 has have VBZ cord-302514-rstvf3mc 95 13 been be VBN cord-302514-rstvf3mc 95 14 extensively extensively RB cord-302514-rstvf3mc 95 15 studied study VBN cord-302514-rstvf3mc 95 16 for for IN cord-302514-rstvf3mc 95 17 its -PRON- PRP$ cord-302514-rstvf3mc 95 18 chemopreventive chemopreventive JJ cord-302514-rstvf3mc 95 19 and and CC cord-302514-rstvf3mc 95 20 chemotherapeutic chemotherapeutic JJ cord-302514-rstvf3mc 95 21 effects effect NNS cord-302514-rstvf3mc 95 22 in in IN cord-302514-rstvf3mc 95 23 cancer cancer NN cord-302514-rstvf3mc 95 24 and and CC cord-302514-rstvf3mc 95 25 animal animal NN cord-302514-rstvf3mc 95 26 models model NNS cord-302514-rstvf3mc 95 27 . . . cord-302514-rstvf3mc 96 1 Resveratrol resveratrol NN cord-302514-rstvf3mc 96 2 blocks block VBZ cord-302514-rstvf3mc 96 3 the the DT cord-302514-rstvf3mc 96 4 angiogenesis angiogenesis NN cord-302514-rstvf3mc 96 5 , , , cord-302514-rstvf3mc 96 6 induces induce VBZ cord-302514-rstvf3mc 96 7 the the DT cord-302514-rstvf3mc 96 8 autophagocytosis autophagocytosis NN cord-302514-rstvf3mc 96 9 and and CC cord-302514-rstvf3mc 96 10 apoptosis apoptosis NN cord-302514-rstvf3mc 96 11 in in IN cord-302514-rstvf3mc 96 12 proliferating proliferate VBG cord-302514-rstvf3mc 96 13 cells cell NNS cord-302514-rstvf3mc 96 14 , , , cord-302514-rstvf3mc 96 15 and and CC cord-302514-rstvf3mc 96 16 is be VBZ cord-302514-rstvf3mc 96 17 a a DT cord-302514-rstvf3mc 96 18 well well RB cord-302514-rstvf3mc 96 19 - - HYPH cord-302514-rstvf3mc 96 20 known know VBN cord-302514-rstvf3mc 96 21 sirtuin sirtuin NNP cord-302514-rstvf3mc 96 22 1 1 CD cord-302514-rstvf3mc 96 23 activator activator NN cord-302514-rstvf3mc 96 24 ( ( -LRB- cord-302514-rstvf3mc 96 25 59 59 CD cord-302514-rstvf3mc 96 26 , , , cord-302514-rstvf3mc 96 27 60 60 CD cord-302514-rstvf3mc 96 28 ) ) -RRB- cord-302514-rstvf3mc 96 29 . . . cord-302514-rstvf3mc 97 1 The the DT cord-302514-rstvf3mc 97 2 expression expression NN cord-302514-rstvf3mc 97 3 of of IN cord-302514-rstvf3mc 97 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 97 5 is be VBZ cord-302514-rstvf3mc 97 6 increased increase VBN cord-302514-rstvf3mc 97 7 in in IN cord-302514-rstvf3mc 97 8 the the DT cord-302514-rstvf3mc 97 9 PA-1 PA-1 NNP cord-302514-rstvf3mc 97 10 ovarian ovarian JJ cord-302514-rstvf3mc 97 11 cell cell NN cord-302514-rstvf3mc 97 12 line line NN cord-302514-rstvf3mc 97 13 after after IN cord-302514-rstvf3mc 97 14 serum serum NN cord-302514-rstvf3mc 97 15 or or CC cord-302514-rstvf3mc 97 16 insulin insulin NN cord-302514-rstvf3mc 97 17 stimulation stimulation NN cord-302514-rstvf3mc 97 18 . . . cord-302514-rstvf3mc 98 1 Resveratrol resveratrol NN cord-302514-rstvf3mc 98 2 up up RB cord-302514-rstvf3mc 98 3 - - : cord-302514-rstvf3mc 98 4 regulates regulate VBZ cord-302514-rstvf3mc 98 5 the the DT cord-302514-rstvf3mc 98 6 caspase-3 caspase-3 NNP cord-302514-rstvf3mc 98 7 level level NN cord-302514-rstvf3mc 98 8 in in IN cord-302514-rstvf3mc 98 9 PA-1 PA-1 NNP cord-302514-rstvf3mc 98 10 cells cell NNS cord-302514-rstvf3mc 98 11 by by IN cord-302514-rstvf3mc 98 12 down down RB cord-302514-rstvf3mc 98 13 regulating regulate VBG cord-302514-rstvf3mc 98 14 the the DT cord-302514-rstvf3mc 98 15 expression expression NN cord-302514-rstvf3mc 98 16 of of IN cord-302514-rstvf3mc 98 17 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 98 18 via via IN cord-302514-rstvf3mc 98 19 the the DT cord-302514-rstvf3mc 98 20 blockade blockade NN cord-302514-rstvf3mc 98 21 of of IN cord-302514-rstvf3mc 98 22 upstream upstream JJ cord-302514-rstvf3mc 98 23 Akt Akt NNP cord-302514-rstvf3mc 98 24 pathway pathway NN cord-302514-rstvf3mc 98 25 . . . cord-302514-rstvf3mc 99 1 Additionally additionally RB cord-302514-rstvf3mc 99 2 , , , cord-302514-rstvf3mc 99 3 resveratrol resveratrol NN cord-302514-rstvf3mc 99 4 suppresses suppress VBZ cord-302514-rstvf3mc 99 5 growth growth NN cord-302514-rstvf3mc 99 6 of of IN cord-302514-rstvf3mc 99 7 human human JJ cord-302514-rstvf3mc 99 8 ovarian ovarian JJ cord-302514-rstvf3mc 99 9 cancer cancer NN cord-302514-rstvf3mc 99 10 cells cell NNS cord-302514-rstvf3mc 99 11 in in IN cord-302514-rstvf3mc 99 12 culture culture NN cord-302514-rstvf3mc 99 13 and and CC cord-302514-rstvf3mc 99 14 in in IN cord-302514-rstvf3mc 99 15 a a DT cord-302514-rstvf3mc 99 16 murine murine JJ cord-302514-rstvf3mc 99 17 xenograft xenograft NN cord-302514-rstvf3mc 99 18 model model NN cord-302514-rstvf3mc 99 19 with with IN cord-302514-rstvf3mc 99 20 reduced reduced JJ cord-302514-rstvf3mc 99 21 expression expression NN cord-302514-rstvf3mc 99 22 of of IN cord-302514-rstvf3mc 99 23 proliferating proliferate VBG cord-302514-rstvf3mc 99 24 cell cell NN cord-302514-rstvf3mc 99 25 nuclear nuclear JJ cord-302514-rstvf3mc 99 26 antigen antigen NN cord-302514-rstvf3mc 99 27 and and CC cord-302514-rstvf3mc 99 28 increased increase VBN cord-302514-rstvf3mc 99 29 TUNEL TUNEL NNP cord-302514-rstvf3mc 99 30 staining staining NN cord-302514-rstvf3mc 99 31 ( ( -LRB- cord-302514-rstvf3mc 99 32 61 61 CD cord-302514-rstvf3mc 99 33 ) ) -RRB- cord-302514-rstvf3mc 99 34 . . . cord-302514-rstvf3mc 100 1 All all DT cord-302514-rstvf3mc 100 2 together together RB cord-302514-rstvf3mc 100 3 resveratrol resveratrol JJ cord-302514-rstvf3mc 100 4 down down RB cord-302514-rstvf3mc 100 5 - - HYPH cord-302514-rstvf3mc 100 6 regulates regulate VBZ cord-302514-rstvf3mc 100 7 eEF1A2 eef1a2 NN cord-302514-rstvf3mc 100 8 in in IN cord-302514-rstvf3mc 100 9 ovarian ovarian JJ cord-302514-rstvf3mc 100 10 cancer cancer NN cord-302514-rstvf3mc 100 11 cells cell NNS cord-302514-rstvf3mc 100 12 and and CC cord-302514-rstvf3mc 100 13 thereby thereby RB cord-302514-rstvf3mc 100 14 favors favor VBZ cord-302514-rstvf3mc 100 15 apoptosis apoptosis NN cord-302514-rstvf3mc 100 16 . . . cord-302514-rstvf3mc 101 1 Lung lung NN cord-302514-rstvf3mc 101 2 cancer cancer NN cord-302514-rstvf3mc 101 3 is be VBZ cord-302514-rstvf3mc 101 4 the the DT cord-302514-rstvf3mc 101 5 most most RBS cord-302514-rstvf3mc 101 6 common common JJ cord-302514-rstvf3mc 101 7 cause cause NN cord-302514-rstvf3mc 101 8 of of IN cord-302514-rstvf3mc 101 9 cancer cancer NN cord-302514-rstvf3mc 101 10 related relate VBN cord-302514-rstvf3mc 101 11 death death NN cord-302514-rstvf3mc 101 12 both both CC cord-302514-rstvf3mc 101 13 in in IN cord-302514-rstvf3mc 101 14 men man NNS cord-302514-rstvf3mc 101 15 and and CC cord-302514-rstvf3mc 101 16 women woman NNS cord-302514-rstvf3mc 101 17 . . . cord-302514-rstvf3mc 102 1 It -PRON- PRP cord-302514-rstvf3mc 102 2 accounts account VBZ cord-302514-rstvf3mc 102 3 for for IN cord-302514-rstvf3mc 102 4 1.3 1.3 CD cord-302514-rstvf3mc 102 5 million million CD cord-302514-rstvf3mc 102 6 deaths death NNS cord-302514-rstvf3mc 102 7 worldwide worldwide RB cord-302514-rstvf3mc 102 8 annually annually RB cord-302514-rstvf3mc 102 9 . . . cord-302514-rstvf3mc 103 1 In in IN cord-302514-rstvf3mc 103 2 spite spite NN cord-302514-rstvf3mc 103 3 of of IN cord-302514-rstvf3mc 103 4 continuous continuous JJ cord-302514-rstvf3mc 103 5 efforts effort NNS cord-302514-rstvf3mc 103 6 and and CC cord-302514-rstvf3mc 103 7 clinical clinical JJ cord-302514-rstvf3mc 103 8 Frontiers Frontiers NNPS cord-302514-rstvf3mc 103 9 in in IN cord-302514-rstvf3mc 103 10 Oncology Oncology NNP cord-302514-rstvf3mc 103 11 | | NNP cord-302514-rstvf3mc 103 12 Molecular Molecular NNP cord-302514-rstvf3mc 103 13 and and CC cord-302514-rstvf3mc 103 14 Cellular Cellular NNP cord-302514-rstvf3mc 103 15 Oncology Oncology NNP cord-302514-rstvf3mc 103 16 trials trial NNS cord-302514-rstvf3mc 103 17 to to TO cord-302514-rstvf3mc 103 18 develop develop VB cord-302514-rstvf3mc 103 19 new new JJ cord-302514-rstvf3mc 103 20 diagnostic diagnostic JJ cord-302514-rstvf3mc 103 21 and and CC cord-302514-rstvf3mc 103 22 prognostic prognostic JJ cord-302514-rstvf3mc 103 23 markers marker NNS cord-302514-rstvf3mc 103 24 , , , cord-302514-rstvf3mc 103 25 a a DT cord-302514-rstvf3mc 103 26 better well JJR cord-302514-rstvf3mc 103 27 understanding understanding NN cord-302514-rstvf3mc 103 28 of of IN cord-302514-rstvf3mc 103 29 the the DT cord-302514-rstvf3mc 103 30 molecular molecular JJ cord-302514-rstvf3mc 103 31 pathways pathway NNS cord-302514-rstvf3mc 103 32 involved involve VBN cord-302514-rstvf3mc 103 33 in in IN cord-302514-rstvf3mc 103 34 lung lung NN cord-302514-rstvf3mc 103 35 cancer cancer NN cord-302514-rstvf3mc 103 36 is be VBZ cord-302514-rstvf3mc 103 37 essential essential JJ cord-302514-rstvf3mc 103 38 for for IN cord-302514-rstvf3mc 103 39 developing develop VBG cord-302514-rstvf3mc 103 40 new new JJ cord-302514-rstvf3mc 103 41 therapeutic therapeutic JJ cord-302514-rstvf3mc 103 42 targets target NNS cord-302514-rstvf3mc 103 43 ( ( -LRB- cord-302514-rstvf3mc 103 44 62 62 CD cord-302514-rstvf3mc 103 45 , , , cord-302514-rstvf3mc 103 46 63 63 CD cord-302514-rstvf3mc 103 47 ) ) -RRB- cord-302514-rstvf3mc 103 48 . . . cord-302514-rstvf3mc 104 1 Four four CD cord-302514-rstvf3mc 104 2 lung lung NN cord-302514-rstvf3mc 104 3 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 104 4 cell cell NN cord-302514-rstvf3mc 104 5 lines line NNS cord-302514-rstvf3mc 104 6 ( ( -LRB- cord-302514-rstvf3mc 104 7 HKULC HKULC NNP cord-302514-rstvf3mc 104 8 1 1 CD cord-302514-rstvf3mc 104 9 - - SYM cord-302514-rstvf3mc 104 10 4 4 CD cord-302514-rstvf3mc 104 11 ) ) -RRB- cord-302514-rstvf3mc 104 12 were be VBD cord-302514-rstvf3mc 104 13 established establish VBN cord-302514-rstvf3mc 104 14 from from IN cord-302514-rstvf3mc 104 15 patients patient NNS cord-302514-rstvf3mc 104 16 with with IN cord-302514-rstvf3mc 104 17 different different JJ cord-302514-rstvf3mc 104 18 clinical clinical JJ cord-302514-rstvf3mc 104 19 characteristics characteristic NNS cord-302514-rstvf3mc 104 20 . . . cord-302514-rstvf3mc 105 1 Comprehensive comprehensive JJ cord-302514-rstvf3mc 105 2 studies study NNS cord-302514-rstvf3mc 105 3 of of IN cord-302514-rstvf3mc 105 4 these these DT cord-302514-rstvf3mc 105 5 cell cell NN cord-302514-rstvf3mc 105 6 lines line NNS cord-302514-rstvf3mc 105 7 show show VBP cord-302514-rstvf3mc 105 8 that that IN cord-302514-rstvf3mc 105 9 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 105 10 is be VBZ cord-302514-rstvf3mc 105 11 a a DT cord-302514-rstvf3mc 105 12 putative putative JJ cord-302514-rstvf3mc 105 13 oncogene oncogene NN cord-302514-rstvf3mc 105 14 that that WDT cord-302514-rstvf3mc 105 15 is be VBZ cord-302514-rstvf3mc 105 16 highly highly RB cord-302514-rstvf3mc 105 17 expressed express VBN cord-302514-rstvf3mc 105 18 in in IN cord-302514-rstvf3mc 105 19 all all PDT cord-302514-rstvf3mc 105 20 the the DT cord-302514-rstvf3mc 105 21 HKULC HKULC NNP cord-302514-rstvf3mc 105 22 cell cell NN cord-302514-rstvf3mc 105 23 lines line NNS cord-302514-rstvf3mc 105 24 ( ( -LRB- cord-302514-rstvf3mc 105 25 64 64 CD cord-302514-rstvf3mc 105 26 ) ) -RRB- cord-302514-rstvf3mc 105 27 . . . cord-302514-rstvf3mc 106 1 In in IN cord-302514-rstvf3mc 106 2 addition addition NN cord-302514-rstvf3mc 106 3 , , , cord-302514-rstvf3mc 106 4 high high JJ cord-302514-rstvf3mc 106 5 - - HYPH cord-302514-rstvf3mc 106 6 resolution resolution NN cord-302514-rstvf3mc 106 7 analysis analysis NN cord-302514-rstvf3mc 106 8 of of IN cord-302514-rstvf3mc 106 9 genomic genomic JJ cord-302514-rstvf3mc 106 10 aberration aberration NN cord-302514-rstvf3mc 106 11 by by IN cord-302514-rstvf3mc 106 12 metaphase metaphase NN cord-302514-rstvf3mc 106 13 and and CC cord-302514-rstvf3mc 106 14 comparative comparative JJ cord-302514-rstvf3mc 106 15 genomic genomic JJ cord-302514-rstvf3mc 106 16 hybridization hybridization NN cord-302514-rstvf3mc 106 17 array array NN cord-302514-rstvf3mc 106 18 identify identify VB cord-302514-rstvf3mc 106 19 the the DT cord-302514-rstvf3mc 106 20 involvement involvement NN cord-302514-rstvf3mc 106 21 of of IN cord-302514-rstvf3mc 106 22 the the DT cord-302514-rstvf3mc 106 23 20q 20q CD cord-302514-rstvf3mc 106 24 region region NN cord-302514-rstvf3mc 106 25 , , , cord-302514-rstvf3mc 106 26 suggesting suggest VBG cord-302514-rstvf3mc 106 27 the the DT cord-302514-rstvf3mc 106 28 potential potential JJ cord-302514-rstvf3mc 106 29 role role NN cord-302514-rstvf3mc 106 30 of of IN cord-302514-rstvf3mc 106 31 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 106 32 as as IN cord-302514-rstvf3mc 106 33 a a DT cord-302514-rstvf3mc 106 34 candidate candidate NN cord-302514-rstvf3mc 106 35 tumor tumor NN cord-302514-rstvf3mc 106 36 gene gene NN cord-302514-rstvf3mc 106 37 in in IN cord-302514-rstvf3mc 106 38 lung lung NN cord-302514-rstvf3mc 106 39 cancer cancer NN cord-302514-rstvf3mc 106 40 cell cell NN cord-302514-rstvf3mc 106 41 lines line NNS cord-302514-rstvf3mc 106 42 ( ( -LRB- cord-302514-rstvf3mc 106 43 41 41 CD cord-302514-rstvf3mc 106 44 ) ) -RRB- cord-302514-rstvf3mc 106 45 . . . cord-302514-rstvf3mc 107 1 In in IN cord-302514-rstvf3mc 107 2 another another DT cord-302514-rstvf3mc 107 3 study study NN cord-302514-rstvf3mc 107 4 , , , cord-302514-rstvf3mc 107 5 183 183 CD cord-302514-rstvf3mc 107 6 genes gene NNS cord-302514-rstvf3mc 107 7 with with IN cord-302514-rstvf3mc 107 8 increment increment NN cord-302514-rstvf3mc 107 9 in in IN cord-302514-rstvf3mc 107 10 both both DT cord-302514-rstvf3mc 107 11 genomic genomic JJ cord-302514-rstvf3mc 107 12 copy copy NN cord-302514-rstvf3mc 107 13 number number NN cord-302514-rstvf3mc 107 14 and and CC cord-302514-rstvf3mc 107 15 transcript transcript NN cord-302514-rstvf3mc 107 16 in in IN cord-302514-rstvf3mc 107 17 six six CD cord-302514-rstvf3mc 107 18 lung lung NN cord-302514-rstvf3mc 107 19 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 107 20 were be VBD cord-302514-rstvf3mc 107 21 analyzed analyze VBN cord-302514-rstvf3mc 107 22 . . . cord-302514-rstvf3mc 108 1 Forty forty CD cord-302514-rstvf3mc 108 2 - - HYPH cord-302514-rstvf3mc 108 3 two two CD cord-302514-rstvf3mc 108 4 proteins protein NNS cord-302514-rstvf3mc 108 5 were be VBD cord-302514-rstvf3mc 108 6 overexpressed overexpresse VBN cord-302514-rstvf3mc 108 7 in in IN cord-302514-rstvf3mc 108 8 these these DT cord-302514-rstvf3mc 108 9 cell cell NN cord-302514-rstvf3mc 108 10 lines line NNS cord-302514-rstvf3mc 108 11 as as IN cord-302514-rstvf3mc 108 12 compared compare VBN cord-302514-rstvf3mc 108 13 to to IN cord-302514-rstvf3mc 108 14 the the DT cord-302514-rstvf3mc 108 15 normal normal JJ cord-302514-rstvf3mc 108 16 cells cell NNS cord-302514-rstvf3mc 108 17 . . . cord-302514-rstvf3mc 109 1 Comparing compare VBG cord-302514-rstvf3mc 109 2 the the DT cord-302514-rstvf3mc 109 3 183 183 CD cord-302514-rstvf3mc 109 4 genes gene NNS cord-302514-rstvf3mc 109 5 with with IN cord-302514-rstvf3mc 109 6 the the DT cord-302514-rstvf3mc 109 7 42 42 CD cord-302514-rstvf3mc 109 8 proteins protein NNS cord-302514-rstvf3mc 109 9 , , , cord-302514-rstvf3mc 109 10 the the DT cord-302514-rstvf3mc 109 11 expression expression NN cord-302514-rstvf3mc 109 12 of of IN cord-302514-rstvf3mc 109 13 four four CD cord-302514-rstvf3mc 109 14 candidates candidate NNS cord-302514-rstvf3mc 109 15 , , , cord-302514-rstvf3mc 109 16 namely namely RB cord-302514-rstvf3mc 109 17 , , , cord-302514-rstvf3mc 109 18 PRDX1 PRDX1 NNP cord-302514-rstvf3mc 109 19 , , , cord-302514-rstvf3mc 109 20 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 109 21 , , , cord-302514-rstvf3mc 109 22 CALR CALR NNP cord-302514-rstvf3mc 109 23 , , , cord-302514-rstvf3mc 109 24 and and CC cord-302514-rstvf3mc 109 25 KCIP-1 KCIP-1 NNP cord-302514-rstvf3mc 109 26 was be VBD cord-302514-rstvf3mc 109 27 correlated correlate VBN cord-302514-rstvf3mc 109 28 with with IN cord-302514-rstvf3mc 109 29 increased increase VBN cord-302514-rstvf3mc 109 30 DNA dna NN cord-302514-rstvf3mc 109 31 copy copy NN cord-302514-rstvf3mc 109 32 number number NN cord-302514-rstvf3mc 109 33 and and CC cord-302514-rstvf3mc 109 34 transcript transcript NN cord-302514-rstvf3mc 109 35 levels level NNS cord-302514-rstvf3mc 109 36 . . . cord-302514-rstvf3mc 110 1 Furthermore furthermore RB cord-302514-rstvf3mc 110 2 , , , cord-302514-rstvf3mc 110 3 expression expression NN cord-302514-rstvf3mc 110 4 of of IN cord-302514-rstvf3mc 110 5 siRNA siRNA NNP cord-302514-rstvf3mc 110 6 targeting target VBG cord-302514-rstvf3mc 110 7 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 110 8 and and CC cord-302514-rstvf3mc 110 9 KCIP-1 KCIP-1 NNPS cord-302514-rstvf3mc 110 10 in in IN cord-302514-rstvf3mc 110 11 these these DT cord-302514-rstvf3mc 110 12 cell cell NN cord-302514-rstvf3mc 110 13 lines line NNS cord-302514-rstvf3mc 110 14 suppressed suppress VBD cord-302514-rstvf3mc 110 15 cellular cellular JJ cord-302514-rstvf3mc 110 16 proliferation proliferation NN cord-302514-rstvf3mc 110 17 and and CC cord-302514-rstvf3mc 110 18 triggered trigger VBD cord-302514-rstvf3mc 110 19 apoptosis apoptosis NN cord-302514-rstvf3mc 110 20 . . . cord-302514-rstvf3mc 111 1 Therefore therefore RB cord-302514-rstvf3mc 111 2 , , , cord-302514-rstvf3mc 111 3 the the DT cord-302514-rstvf3mc 111 4 overexpression overexpression NN cord-302514-rstvf3mc 111 5 of of IN cord-302514-rstvf3mc 111 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 111 7 and and CC cord-302514-rstvf3mc 111 8 KCIP-1 KCIP-1 NNP cord-302514-rstvf3mc 111 9 in in IN cord-302514-rstvf3mc 111 10 lung lung NN cord-302514-rstvf3mc 111 11 tumor tumor NN cord-302514-rstvf3mc 111 12 samples sample NNS cord-302514-rstvf3mc 111 13 strongly strongly RB cord-302514-rstvf3mc 111 14 suggests suggest VBZ cord-302514-rstvf3mc 111 15 that that IN cord-302514-rstvf3mc 111 16 both both DT cord-302514-rstvf3mc 111 17 proteins protein NNS cord-302514-rstvf3mc 111 18 could could MD cord-302514-rstvf3mc 111 19 be be VB cord-302514-rstvf3mc 111 20 involved involve VBN cord-302514-rstvf3mc 111 21 in in IN cord-302514-rstvf3mc 111 22 lung lung NN cord-302514-rstvf3mc 111 23 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 111 24 and and CC cord-302514-rstvf3mc 111 25 could could MD cord-302514-rstvf3mc 111 26 be be VB cord-302514-rstvf3mc 111 27 potential potential JJ cord-302514-rstvf3mc 111 28 therapeutic therapeutic JJ cord-302514-rstvf3mc 111 29 targets target NNS cord-302514-rstvf3mc 111 30 in in IN cord-302514-rstvf3mc 111 31 lung lung NN cord-302514-rstvf3mc 111 32 cancer cancer NN cord-302514-rstvf3mc 111 33 ( ( -LRB- cord-302514-rstvf3mc 111 34 42 42 CD cord-302514-rstvf3mc 111 35 ) ) -RRB- cord-302514-rstvf3mc 111 36 . . . cord-302514-rstvf3mc 112 1 Hepatocellular hepatocellular JJ cord-302514-rstvf3mc 112 2 carcinoma carcinoma NN cord-302514-rstvf3mc 112 3 ( ( -LRB- cord-302514-rstvf3mc 112 4 HCC HCC NNP cord-302514-rstvf3mc 112 5 ) ) -RRB- cord-302514-rstvf3mc 112 6 is be VBZ cord-302514-rstvf3mc 112 7 one one CD cord-302514-rstvf3mc 112 8 of of IN cord-302514-rstvf3mc 112 9 the the DT cord-302514-rstvf3mc 112 10 most most RBS cord-302514-rstvf3mc 112 11 common common JJ cord-302514-rstvf3mc 112 12 malignant malignant JJ cord-302514-rstvf3mc 112 13 tumors tumor NNS cord-302514-rstvf3mc 112 14 in in IN cord-302514-rstvf3mc 112 15 humans human NNS cord-302514-rstvf3mc 112 16 ( ( -LRB- cord-302514-rstvf3mc 112 17 65 65 CD cord-302514-rstvf3mc 112 18 , , , cord-302514-rstvf3mc 112 19 66 66 CD cord-302514-rstvf3mc 112 20 ) ) -RRB- cord-302514-rstvf3mc 112 21 . . . cord-302514-rstvf3mc 113 1 HCC HCC NNP cord-302514-rstvf3mc 113 2 cell cell NN cord-302514-rstvf3mc 113 3 lines line NNS cord-302514-rstvf3mc 113 4 , , , cord-302514-rstvf3mc 113 5 HepG2 HepG2 NNP cord-302514-rstvf3mc 113 6 , , , cord-302514-rstvf3mc 113 7 HuH7 HuH7 NNS cord-302514-rstvf3mc 113 8 , , , cord-302514-rstvf3mc 113 9 and and CC cord-302514-rstvf3mc 114 1 JHH6 jhh6 JJ cord-302514-rstvf3mc 114 2 show show NN cord-302514-rstvf3mc 114 3 increased increase VBN cord-302514-rstvf3mc 114 4 expression expression NN cord-302514-rstvf3mc 114 5 of of IN cord-302514-rstvf3mc 114 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 114 7 as as IN cord-302514-rstvf3mc 114 8 compare compare NN cord-302514-rstvf3mc 114 9 to to IN cord-302514-rstvf3mc 114 10 normal normal JJ cord-302514-rstvf3mc 114 11 liver liver NN cord-302514-rstvf3mc 114 12 tissue tissue NN cord-302514-rstvf3mc 114 13 , , , cord-302514-rstvf3mc 114 14 but but CC cord-302514-rstvf3mc 114 15 the the DT cord-302514-rstvf3mc 114 16 mRNA mrna NN cord-302514-rstvf3mc 114 17 of of IN cord-302514-rstvf3mc 114 18 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 114 19 is be VBZ cord-302514-rstvf3mc 114 20 markedly markedly RB cord-302514-rstvf3mc 114 21 increased increase VBN cord-302514-rstvf3mc 114 22 only only RB cord-302514-rstvf3mc 114 23 in in IN cord-302514-rstvf3mc 114 24 JHH6 JHH6 NNP cord-302514-rstvf3mc 114 25 cells cell NNS cord-302514-rstvf3mc 114 26 ( ( -LRB- cord-302514-rstvf3mc 114 27 43 43 CD cord-302514-rstvf3mc 114 28 ) ) -RRB- cord-302514-rstvf3mc 114 29 . . . cord-302514-rstvf3mc 115 1 In in IN cord-302514-rstvf3mc 115 2 addition addition NN cord-302514-rstvf3mc 115 3 , , , cord-302514-rstvf3mc 115 4 the the DT cord-302514-rstvf3mc 115 5 MDM4 MDM4 NNP cord-302514-rstvf3mc 115 6 and and CC cord-302514-rstvf3mc 115 7 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 115 8 proteins protein NNS cord-302514-rstvf3mc 115 9 show show VBP cord-302514-rstvf3mc 115 10 increased increase VBN cord-302514-rstvf3mc 115 11 expression expression NN cord-302514-rstvf3mc 115 12 in in IN cord-302514-rstvf3mc 115 13 cryptogenic cryptogenic JJ cord-302514-rstvf3mc 115 14 HCC HCC NNP cord-302514-rstvf3mc 115 15 ( ( -LRB- cord-302514-rstvf3mc 115 16 44 44 CD cord-302514-rstvf3mc 115 17 ) ) -RRB- cord-302514-rstvf3mc 115 18 . . . cord-302514-rstvf3mc 116 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 116 2 gene gene NN cord-302514-rstvf3mc 116 3 silencing silencing NN cord-302514-rstvf3mc 116 4 reduces reduce VBZ cord-302514-rstvf3mc 116 5 cell cell NN cord-302514-rstvf3mc 116 6 viability viability NN cord-302514-rstvf3mc 116 7 , , , cord-302514-rstvf3mc 116 8 proliferation proliferation NN cord-302514-rstvf3mc 116 9 , , , cord-302514-rstvf3mc 116 10 and and CC cord-302514-rstvf3mc 116 11 increases increase VBZ cord-302514-rstvf3mc 116 12 the the DT cord-302514-rstvf3mc 116 13 apoptosis apoptosis NN cord-302514-rstvf3mc 116 14 rates rate NNS cord-302514-rstvf3mc 116 15 in in IN cord-302514-rstvf3mc 116 16 HCC HCC NNP cord-302514-rstvf3mc 116 17 cell cell NN cord-302514-rstvf3mc 116 18 lines line NNS cord-302514-rstvf3mc 116 19 ( ( -LRB- cord-302514-rstvf3mc 116 20 44 44 CD cord-302514-rstvf3mc 116 21 ) ) -RRB- cord-302514-rstvf3mc 116 22 . . . cord-302514-rstvf3mc 117 1 Furthermore furthermore RB cord-302514-rstvf3mc 117 2 , , , cord-302514-rstvf3mc 117 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 117 4 is be VBZ cord-302514-rstvf3mc 117 5 overexpressed overexpresse VBN cord-302514-rstvf3mc 117 6 in in IN cord-302514-rstvf3mc 117 7 43 43 CD cord-302514-rstvf3mc 117 8 % % NN cord-302514-rstvf3mc 117 9 of of IN cord-302514-rstvf3mc 117 10 HCC HCC NNP cord-302514-rstvf3mc 117 11 and and CC cord-302514-rstvf3mc 117 12 activates activate VBZ cord-302514-rstvf3mc 117 13 the the DT cord-302514-rstvf3mc 117 14 Akt Akt NNP cord-302514-rstvf3mc 117 15 pathway pathway NN cord-302514-rstvf3mc 117 16 as as IN cord-302514-rstvf3mc 117 17 observed observe VBN cord-302514-rstvf3mc 117 18 in in IN cord-302514-rstvf3mc 117 19 40 40 CD cord-302514-rstvf3mc 117 20 - - SYM cord-302514-rstvf3mc 117 21 60 60 CD cord-302514-rstvf3mc 117 22 % % NN cord-302514-rstvf3mc 117 23 of of IN cord-302514-rstvf3mc 117 24 primary primary JJ cord-302514-rstvf3mc 117 25 HCCs hcc NNS cord-302514-rstvf3mc 117 26 ( ( -LRB- cord-302514-rstvf3mc 117 27 Table table NN cord-302514-rstvf3mc 117 28 2 2 CD cord-302514-rstvf3mc 117 29 ) ) -RRB- cord-302514-rstvf3mc 117 30 ( ( -LRB- cord-302514-rstvf3mc 117 31 44 44 CD cord-302514-rstvf3mc 117 32 , , , cord-302514-rstvf3mc 117 33 67 67 CD cord-302514-rstvf3mc 117 34 ) ) -RRB- cord-302514-rstvf3mc 117 35 . . . cord-302514-rstvf3mc 118 1 Using use VBG cord-302514-rstvf3mc 118 2 array array NN cord-302514-rstvf3mc 118 3 based base VBN cord-302514-rstvf3mc 118 4 comparative comparative JJ cord-302514-rstvf3mc 118 5 genomic genomic JJ cord-302514-rstvf3mc 118 6 hybridization hybridization NN cord-302514-rstvf3mc 118 7 , , , cord-302514-rstvf3mc 118 8 frequent frequent JJ cord-302514-rstvf3mc 118 9 amplification amplification NN cord-302514-rstvf3mc 118 10 and and CC cord-302514-rstvf3mc 118 11 gain gain NN cord-302514-rstvf3mc 118 12 of of IN cord-302514-rstvf3mc 118 13 DNA dna NN cord-302514-rstvf3mc 118 14 copy copy NN cord-302514-rstvf3mc 118 15 number number NN cord-302514-rstvf3mc 118 16 at at IN cord-302514-rstvf3mc 118 17 1q 1q CD cord-302514-rstvf3mc 118 18 , , , cord-302514-rstvf3mc 118 19 6p 6p CD cord-302514-rstvf3mc 118 20 , , , cord-302514-rstvf3mc 118 21 8q 8q NNP cord-302514-rstvf3mc 118 22 , , , cord-302514-rstvf3mc 118 23 17q 17q CD cord-302514-rstvf3mc 118 24 , , , cord-302514-rstvf3mc 118 25 and and CC cord-302514-rstvf3mc 118 26 20q 20q NNS cord-302514-rstvf3mc 118 27 were be VBD cord-302514-rstvf3mc 118 28 observed observe VBN cord-302514-rstvf3mc 118 29 in in IN cord-302514-rstvf3mc 118 30 HCCs hcc NNS cord-302514-rstvf3mc 118 31 , , , cord-302514-rstvf3mc 118 32 suggesting suggest VBG cord-302514-rstvf3mc 118 33 that that IN cord-302514-rstvf3mc 118 34 these these DT cord-302514-rstvf3mc 118 35 genetic genetic JJ cord-302514-rstvf3mc 118 36 aberrations aberration NNS cord-302514-rstvf3mc 118 37 might may MD cord-302514-rstvf3mc 118 38 facilitate facilitate VB cord-302514-rstvf3mc 118 39 the the DT cord-302514-rstvf3mc 118 40 malignant malignant JJ cord-302514-rstvf3mc 118 41 transformation transformation NN cord-302514-rstvf3mc 118 42 ( ( -LRB- cord-302514-rstvf3mc 118 43 68 68 CD cord-302514-rstvf3mc 118 44 ) ) -RRB- cord-302514-rstvf3mc 118 45 . . . cord-302514-rstvf3mc 119 1 Pancreatic pancreatic JJ cord-302514-rstvf3mc 119 2 cancer cancer NN cord-302514-rstvf3mc 119 3 is be VBZ cord-302514-rstvf3mc 119 4 one one CD cord-302514-rstvf3mc 119 5 of of IN cord-302514-rstvf3mc 119 6 the the DT cord-302514-rstvf3mc 119 7 unsolved unsolved JJ cord-302514-rstvf3mc 119 8 health health NN cord-302514-rstvf3mc 119 9 problems problem NNS cord-302514-rstvf3mc 119 10 associated associate VBN cord-302514-rstvf3mc 119 11 with with IN cord-302514-rstvf3mc 119 12 aggressive aggressive JJ cord-302514-rstvf3mc 119 13 malignancies malignancy NNS cord-302514-rstvf3mc 119 14 and and CC cord-302514-rstvf3mc 119 15 therefore therefore RB cord-302514-rstvf3mc 119 16 there there EX cord-302514-rstvf3mc 119 17 is be VBZ cord-302514-rstvf3mc 119 18 need need NN cord-302514-rstvf3mc 119 19 to to TO cord-302514-rstvf3mc 119 20 develop develop VB cord-302514-rstvf3mc 119 21 improved improve VBN cord-302514-rstvf3mc 119 22 early early JJ cord-302514-rstvf3mc 119 23 diagnosis diagnosis NN cord-302514-rstvf3mc 119 24 tools tool NNS cord-302514-rstvf3mc 119 25 ( ( -LRB- cord-302514-rstvf3mc 119 26 69 69 CD cord-302514-rstvf3mc 119 27 , , , cord-302514-rstvf3mc 119 28 70 70 CD cord-302514-rstvf3mc 119 29 ) ) -RRB- cord-302514-rstvf3mc 119 30 . . . cord-302514-rstvf3mc 120 1 The the DT cord-302514-rstvf3mc 120 2 expression expression NN cord-302514-rstvf3mc 120 3 of of IN cord-302514-rstvf3mc 120 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 120 5 gene gene NN cord-302514-rstvf3mc 120 6 , , , cord-302514-rstvf3mc 120 7 located locate VBN cord-302514-rstvf3mc 120 8 on on IN cord-302514-rstvf3mc 120 9 chromosome chromosome NN cord-302514-rstvf3mc 120 10 20q13 20q13 CD cord-302514-rstvf3mc 120 11 is be VBZ cord-302514-rstvf3mc 120 12 significantly significantly RB cord-302514-rstvf3mc 120 13 upregulated upregulate VBN cord-302514-rstvf3mc 120 14 in in IN cord-302514-rstvf3mc 120 15 pancreatic pancreatic JJ cord-302514-rstvf3mc 120 16 cancer cancer NN cord-302514-rstvf3mc 120 17 . . . cord-302514-rstvf3mc 121 1 Although although IN cord-302514-rstvf3mc 121 2 little little JJ cord-302514-rstvf3mc 121 3 or or CC cord-302514-rstvf3mc 121 4 no no DT cord-302514-rstvf3mc 121 5 eEF1A2 eef1a2 XX cord-302514-rstvf3mc 121 6 expression expression NN cord-302514-rstvf3mc 121 7 is be VBZ cord-302514-rstvf3mc 121 8 present present JJ cord-302514-rstvf3mc 121 9 in in IN cord-302514-rstvf3mc 121 10 normal normal JJ cord-302514-rstvf3mc 121 11 pancreatic pancreatic JJ cord-302514-rstvf3mc 121 12 tissue tissue NN cord-302514-rstvf3mc 121 13 , , , cord-302514-rstvf3mc 121 14 83 83 CD cord-302514-rstvf3mc 121 15 % % NN cord-302514-rstvf3mc 121 16 of of IN cord-302514-rstvf3mc 121 17 pancreatic pancreatic JJ cord-302514-rstvf3mc 121 18 cancers cancer NNS cord-302514-rstvf3mc 121 19 display display NN cord-302514-rstvf3mc 121 20 increased increase VBN cord-302514-rstvf3mc 121 21 expression expression NN cord-302514-rstvf3mc 121 22 of of IN cord-302514-rstvf3mc 121 23 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 121 24 , , , cord-302514-rstvf3mc 121 25 suggesting suggest VBG cord-302514-rstvf3mc 121 26 that that IN cord-302514-rstvf3mc 121 27 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 121 28 plays play VBZ cord-302514-rstvf3mc 121 29 an an DT cord-302514-rstvf3mc 121 30 important important JJ cord-302514-rstvf3mc 121 31 role role NN cord-302514-rstvf3mc 121 32 in in IN cord-302514-rstvf3mc 121 33 pancreatic pancreatic JJ cord-302514-rstvf3mc 121 34 carcinogenesis carcinogenesis NN cord-302514-rstvf3mc 121 35 ( ( -LRB- cord-302514-rstvf3mc 121 36 71 71 CD cord-302514-rstvf3mc 121 37 ) ) -RRB- cord-302514-rstvf3mc 122 1 ( ( -LRB- cord-302514-rstvf3mc 122 2 72 72 CD cord-302514-rstvf3mc 122 3 ) ) -RRB- cord-302514-rstvf3mc 122 4 ( ( -LRB- cord-302514-rstvf3mc 122 5 73 73 CD cord-302514-rstvf3mc 122 6 ) ) -RRB- cord-302514-rstvf3mc 122 7 . . . cord-302514-rstvf3mc 123 1 Cell cell NN cord-302514-rstvf3mc 123 2 proliferation proliferation NN cord-302514-rstvf3mc 123 3 and and CC cord-302514-rstvf3mc 123 4 cell cell NN cord-302514-rstvf3mc 123 5 death death NN cord-302514-rstvf3mc 123 6 are be VBP cord-302514-rstvf3mc 123 7 highly highly RB cord-302514-rstvf3mc 123 8 regulated regulate VBN cord-302514-rstvf3mc 123 9 and and CC cord-302514-rstvf3mc 123 10 coordinated coordinate VBN cord-302514-rstvf3mc 123 11 during during IN cord-302514-rstvf3mc 123 12 the the DT cord-302514-rstvf3mc 123 13 normal normal JJ cord-302514-rstvf3mc 123 14 development development NN cord-302514-rstvf3mc 123 15 , , , cord-302514-rstvf3mc 123 16 and and CC cord-302514-rstvf3mc 123 17 both both DT cord-302514-rstvf3mc 123 18 are be VBP cord-302514-rstvf3mc 123 19 crucial crucial JJ cord-302514-rstvf3mc 123 20 for for IN cord-302514-rstvf3mc 123 21 the the DT cord-302514-rstvf3mc 123 22 maintenance maintenance NN cord-302514-rstvf3mc 123 23 of of IN cord-302514-rstvf3mc 123 24 tissue tissue NN cord-302514-rstvf3mc 123 25 homeostasis homeostasis NN cord-302514-rstvf3mc 123 26 . . . cord-302514-rstvf3mc 124 1 Impaired impaired JJ cord-302514-rstvf3mc 124 2 apoptosis apoptosis NN cord-302514-rstvf3mc 124 3 can can MD cord-302514-rstvf3mc 124 4 lead lead VB cord-302514-rstvf3mc 124 5 to to IN cord-302514-rstvf3mc 124 6 autoimmunity autoimmunity NN cord-302514-rstvf3mc 124 7 or or CC cord-302514-rstvf3mc 124 8 malignancy malignancy NN cord-302514-rstvf3mc 124 9 ( ( -LRB- cord-302514-rstvf3mc 124 10 74 74 CD cord-302514-rstvf3mc 124 11 , , , cord-302514-rstvf3mc 124 12 75 75 CD cord-302514-rstvf3mc 124 13 ) ) -RRB- cord-302514-rstvf3mc 124 14 . . . cord-302514-rstvf3mc 125 1 An an DT cord-302514-rstvf3mc 125 2 increasing increase VBG cord-302514-rstvf3mc 125 3 number number NN cord-302514-rstvf3mc 125 4 of of IN cord-302514-rstvf3mc 125 5 evidence evidence NN cord-302514-rstvf3mc 125 6 suggests suggest VBZ cord-302514-rstvf3mc 125 7 the the DT cord-302514-rstvf3mc 125 8 involvement involvement NN cord-302514-rstvf3mc 125 9 of of IN cord-302514-rstvf3mc 125 10 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 125 11 at at IN cord-302514-rstvf3mc 125 12 the the DT cord-302514-rstvf3mc 125 13 onset onset NN cord-302514-rstvf3mc 125 14 of of IN cord-302514-rstvf3mc 125 15 cell cell NN cord-302514-rstvf3mc 125 16 transformation transformation NN cord-302514-rstvf3mc 125 17 . . . cord-302514-rstvf3mc 126 1 Peroxiredoxin-1 Peroxiredoxin-1 NNP cord-302514-rstvf3mc 126 2 ( ( -LRB- cord-302514-rstvf3mc 126 3 Prx-1 Prx-1 NNP cord-302514-rstvf3mc 126 4 ) ) -RRB- cord-302514-rstvf3mc 126 5 is be VBZ cord-302514-rstvf3mc 126 6 a a DT cord-302514-rstvf3mc 126 7 protein protein NN cord-302514-rstvf3mc 126 8 that that WDT cord-302514-rstvf3mc 126 9 is be VBZ cord-302514-rstvf3mc 126 10 ubiquitously ubiquitously RB cord-302514-rstvf3mc 126 11 expressed express VBN cord-302514-rstvf3mc 126 12 in in IN cord-302514-rstvf3mc 126 13 all all DT cord-302514-rstvf3mc 126 14 mammalian mammalian JJ cord-302514-rstvf3mc 126 15 cells cell NNS cord-302514-rstvf3mc 126 16 and and CC cord-302514-rstvf3mc 126 17 protects protect VBZ cord-302514-rstvf3mc 126 18 the the DT cord-302514-rstvf3mc 126 19 cells cell NNS cord-302514-rstvf3mc 126 20 from from IN cord-302514-rstvf3mc 126 21 oxidative oxidative JJ cord-302514-rstvf3mc 126 22 stress stress NN cord-302514-rstvf3mc 126 23 by by IN cord-302514-rstvf3mc 126 24 reducing reduce VBG cord-302514-rstvf3mc 126 25 the the DT cord-302514-rstvf3mc 126 26 range range NN cord-302514-rstvf3mc 126 27 of of IN cord-302514-rstvf3mc 126 28 reactive reactive JJ cord-302514-rstvf3mc 126 29 oxygen oxygen NN cord-302514-rstvf3mc 126 30 species specie NNS cord-302514-rstvf3mc 126 31 . . . cord-302514-rstvf3mc 127 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 127 2 interacts interact VBZ cord-302514-rstvf3mc 127 3 directly directly RB cord-302514-rstvf3mc 127 4 with with IN cord-302514-rstvf3mc 127 5 Prx-1 Prx-1 NNP cord-302514-rstvf3mc 127 6 and and CC cord-302514-rstvf3mc 127 7 protects protect VBZ cord-302514-rstvf3mc 127 8 the the DT cord-302514-rstvf3mc 127 9 cells cell NNS cord-302514-rstvf3mc 127 10 from from IN cord-302514-rstvf3mc 127 11 stress stress NN cord-302514-rstvf3mc 127 12 - - HYPH cord-302514-rstvf3mc 127 13 induced induce VBN cord-302514-rstvf3mc 127 14 apoptosis apoptosis NN cord-302514-rstvf3mc 127 15 by by IN cord-302514-rstvf3mc 127 16 the the DT cord-302514-rstvf3mc 127 17 down down JJ cord-302514-rstvf3mc 127 18 - - HYPH cord-302514-rstvf3mc 127 19 regulation regulation NN cord-302514-rstvf3mc 127 20 of of IN cord-302514-rstvf3mc 127 21 caspase-3 caspase-3 NNP cord-302514-rstvf3mc 127 22 and and CC cord-302514-rstvf3mc 127 23 caspase-8 caspase-8 NNP cord-302514-rstvf3mc 127 24 activation activation NN cord-302514-rstvf3mc 127 25 parallel parallel NN cord-302514-rstvf3mc 127 26 to to IN cord-302514-rstvf3mc 127 27 increased increase VBN cord-302514-rstvf3mc 127 28 expression expression NN cord-302514-rstvf3mc 127 29 of of IN cord-302514-rstvf3mc 127 30 the the DT cord-302514-rstvf3mc 127 31 pro pro JJ cord-302514-rstvf3mc 127 32 - - JJ cord-302514-rstvf3mc 127 33 survival survival JJ cord-302514-rstvf3mc 127 34 factor factor NN cord-302514-rstvf3mc 128 1 Akt Akt NNP cord-302514-rstvf3mc 128 2 ( ( -LRB- cord-302514-rstvf3mc 128 3 76 76 CD cord-302514-rstvf3mc 128 4 , , , cord-302514-rstvf3mc 128 5 77 77 CD cord-302514-rstvf3mc 128 6 ) ) -RRB- cord-302514-rstvf3mc 128 7 . . . cord-302514-rstvf3mc 129 1 Additionally additionally RB cord-302514-rstvf3mc 129 2 , , , cord-302514-rstvf3mc 129 3 the the DT cord-302514-rstvf3mc 129 4 eEF1A eef1a CD cord-302514-rstvf3mc 129 5 expression expression NN cord-302514-rstvf3mc 129 6 varies vary VBZ cord-302514-rstvf3mc 129 7 in in IN cord-302514-rstvf3mc 129 8 cells cell NNS cord-302514-rstvf3mc 129 9 treated treat VBN cord-302514-rstvf3mc 129 10 with with IN cord-302514-rstvf3mc 129 11 various various JJ cord-302514-rstvf3mc 129 12 concentrations concentration NNS cord-302514-rstvf3mc 129 13 of of IN cord-302514-rstvf3mc 129 14 hydrogen hydrogen NN cord-302514-rstvf3mc 129 15 peroxide peroxide NN cord-302514-rstvf3mc 129 16 , , , cord-302514-rstvf3mc 129 17 a a DT cord-302514-rstvf3mc 129 18 strong strong JJ cord-302514-rstvf3mc 129 19 apoptotic apoptotic JJ cord-302514-rstvf3mc 129 20 inducer inducer NN cord-302514-rstvf3mc 129 21 associated associate VBN cord-302514-rstvf3mc 129 22 with with IN cord-302514-rstvf3mc 129 23 decreased decrease VBN cord-302514-rstvf3mc 129 24 mitochondrial mitochondrial JJ cord-302514-rstvf3mc 129 25 respiration respiration NN cord-302514-rstvf3mc 129 26 and and CC cord-302514-rstvf3mc 129 27 an an DT cord-302514-rstvf3mc 129 28 inhibitor inhibitor NN cord-302514-rstvf3mc 129 29 of of IN cord-302514-rstvf3mc 129 30 Prx-1 Prx-1 NNP cord-302514-rstvf3mc 129 31 ( ( -LRB- cord-302514-rstvf3mc 129 32 78 78 CD cord-302514-rstvf3mc 129 33 , , , cord-302514-rstvf3mc 129 34 79 79 CD cord-302514-rstvf3mc 129 35 ) ) -RRB- cord-302514-rstvf3mc 129 36 . . . cord-302514-rstvf3mc 130 1 Finally finally RB cord-302514-rstvf3mc 130 2 , , , cord-302514-rstvf3mc 130 3 eEF1A eef1a PRP cord-302514-rstvf3mc 130 4 provides provide VBZ cord-302514-rstvf3mc 130 5 protection protection NN cord-302514-rstvf3mc 130 6 against against IN cord-302514-rstvf3mc 130 7 all all DT cord-302514-rstvf3mc 130 8 endoplasmic endoplasmic NN cord-302514-rstvf3mc 130 9 reticulum reticulum NN cord-302514-rstvf3mc 130 10 ( ( -LRB- cord-302514-rstvf3mc 130 11 ER ER NNP cord-302514-rstvf3mc 130 12 ) ) -RRB- cord-302514-rstvf3mc 130 13 stress stress NN cord-302514-rstvf3mc 130 14 - - HYPH cord-302514-rstvf3mc 130 15 mediated mediate VBN cord-302514-rstvf3mc 130 16 cell cell NN cord-302514-rstvf3mc 130 17 death death NN cord-302514-rstvf3mc 130 18 . . . cord-302514-rstvf3mc 131 1 FL5.12 FL5.12 NNP cord-302514-rstvf3mc 131 2 cells cell NNS cord-302514-rstvf3mc 131 3 are be VBP cord-302514-rstvf3mc 131 4 non non JJ cord-302514-rstvf3mc 131 5 - - JJ cord-302514-rstvf3mc 131 6 transformed transform VBN cord-302514-rstvf3mc 131 7 murine murine JJ cord-302514-rstvf3mc 131 8 B b NN cord-302514-rstvf3mc 131 9 - - HYPH cord-302514-rstvf3mc 131 10 cells cell NNS cord-302514-rstvf3mc 131 11 that that WDT cord-302514-rstvf3mc 131 12 require require VBP cord-302514-rstvf3mc 131 13 IL-3 IL-3 NNP cord-302514-rstvf3mc 131 14 for for IN cord-302514-rstvf3mc 131 15 growth growth NN cord-302514-rstvf3mc 131 16 , , , cord-302514-rstvf3mc 131 17 survival survival NN cord-302514-rstvf3mc 131 18 , , , cord-302514-rstvf3mc 131 19 and and CC cord-302514-rstvf3mc 131 20 proliferation proliferation NN cord-302514-rstvf3mc 131 21 . . . cord-302514-rstvf3mc 132 1 Enforced enforce VBN cord-302514-rstvf3mc 132 2 expression expression NN cord-302514-rstvf3mc 132 3 of of IN cord-302514-rstvf3mc 132 4 eEF1A eef1a NN cord-302514-rstvf3mc 132 5 in in IN cord-302514-rstvf3mc 132 6 these these DT cord-302514-rstvf3mc 132 7 cells cell NNS cord-302514-rstvf3mc 132 8 protects protect VBZ cord-302514-rstvf3mc 132 9 them -PRON- PRP cord-302514-rstvf3mc 132 10 from from IN cord-302514-rstvf3mc 132 11 IL-3 IL-3 NNP cord-302514-rstvf3mc 132 12 withdrawal withdrawal NN cord-302514-rstvf3mc 132 13 without without IN cord-302514-rstvf3mc 132 14 cellular cellular JJ cord-302514-rstvf3mc 132 15 transformation transformation NN cord-302514-rstvf3mc 132 16 ( ( -LRB- cord-302514-rstvf3mc 132 17 80 80 CD cord-302514-rstvf3mc 132 18 ) ) -RRB- cord-302514-rstvf3mc 132 19 . . . cord-302514-rstvf3mc 133 1 Wasted wasted JJ cord-302514-rstvf3mc 133 2 mouse mouse NN cord-302514-rstvf3mc 133 3 is be VBZ cord-302514-rstvf3mc 133 4 a a DT cord-302514-rstvf3mc 133 5 spontaneous spontaneous JJ cord-302514-rstvf3mc 133 6 autosomal autosomal JJ cord-302514-rstvf3mc 133 7 recessive recessive JJ cord-302514-rstvf3mc 133 8 mutation mutation NN cord-302514-rstvf3mc 133 9 associated associate VBN cord-302514-rstvf3mc 133 10 with with IN cord-302514-rstvf3mc 133 11 neurological neurological JJ cord-302514-rstvf3mc 133 12 defects defect NNS cord-302514-rstvf3mc 133 13 , , , cord-302514-rstvf3mc 133 14 immune immune JJ cord-302514-rstvf3mc 133 15 system system NN cord-302514-rstvf3mc 133 16 abnormalities abnormality NNS cord-302514-rstvf3mc 133 17 , , , cord-302514-rstvf3mc 133 18 and and CC cord-302514-rstvf3mc 133 19 defective defective JJ cord-302514-rstvf3mc 133 20 response response NN cord-302514-rstvf3mc 133 21 to to IN cord-302514-rstvf3mc 133 22 DNA dna NN cord-302514-rstvf3mc 133 23 damage damage NN cord-302514-rstvf3mc 133 24 repair repair NN cord-302514-rstvf3mc 133 25 www.frontiersin.org www.frontiersin.org NN cord-302514-rstvf3mc 133 26 in in IN cord-302514-rstvf3mc 133 27 immune immune JJ cord-302514-rstvf3mc 133 28 cells cell NNS cord-302514-rstvf3mc 133 29 . . . cord-302514-rstvf3mc 134 1 Thymus thymus NN cord-302514-rstvf3mc 134 2 and and CC cord-302514-rstvf3mc 134 3 spleen spleen NNS cord-302514-rstvf3mc 134 4 from from IN cord-302514-rstvf3mc 134 5 wasted waste VBN cord-302514-rstvf3mc 134 6 mice mouse NNS cord-302514-rstvf3mc 134 7 show show VBP cord-302514-rstvf3mc 134 8 extensive extensive JJ cord-302514-rstvf3mc 134 9 apoptosis apoptosis NN cord-302514-rstvf3mc 134 10 . . . cord-302514-rstvf3mc 135 1 The the DT cord-302514-rstvf3mc 135 2 loss loss NN cord-302514-rstvf3mc 135 3 of of IN cord-302514-rstvf3mc 135 4 activity activity NN cord-302514-rstvf3mc 135 5 in in IN cord-302514-rstvf3mc 135 6 wasted waste VBN cord-302514-rstvf3mc 135 7 mice mouse NNS cord-302514-rstvf3mc 135 8 and and CC cord-302514-rstvf3mc 135 9 immunological immunological JJ cord-302514-rstvf3mc 135 10 abnormalities abnormality NNS cord-302514-rstvf3mc 135 11 are be VBP cord-302514-rstvf3mc 135 12 solely solely RB cord-302514-rstvf3mc 135 13 linked link VBN cord-302514-rstvf3mc 135 14 to to IN cord-302514-rstvf3mc 135 15 the the DT cord-302514-rstvf3mc 135 16 presence presence NN cord-302514-rstvf3mc 135 17 of of IN cord-302514-rstvf3mc 135 18 a a DT cord-302514-rstvf3mc 135 19 deletion deletion NN cord-302514-rstvf3mc 135 20 in in IN cord-302514-rstvf3mc 135 21 the the DT cord-302514-rstvf3mc 135 22 eef1a2 eef1a2 NNP cord-302514-rstvf3mc 135 23 gene gene NN cord-302514-rstvf3mc 135 24 ( ( -LRB- cord-302514-rstvf3mc 135 25 81 81 CD cord-302514-rstvf3mc 135 26 ) ) -RRB- cord-302514-rstvf3mc 135 27 ( ( -LRB- cord-302514-rstvf3mc 135 28 82 82 CD cord-302514-rstvf3mc 135 29 ) ) -RRB- cord-302514-rstvf3mc 135 30 ( ( -LRB- cord-302514-rstvf3mc 135 31 83 83 CD cord-302514-rstvf3mc 135 32 ) ) -RRB- cord-302514-rstvf3mc 135 33 ( ( -LRB- cord-302514-rstvf3mc 135 34 84 84 CD cord-302514-rstvf3mc 135 35 ) ) -RRB- cord-302514-rstvf3mc 135 36 . . . cord-302514-rstvf3mc 136 1 Furthermore furthermore RB cord-302514-rstvf3mc 136 2 , , , cord-302514-rstvf3mc 136 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 136 4 is be VBZ cord-302514-rstvf3mc 136 5 highly highly RB cord-302514-rstvf3mc 136 6 expressed express VBN cord-302514-rstvf3mc 136 7 in in IN cord-302514-rstvf3mc 136 8 terminally terminally RB cord-302514-rstvf3mc 136 9 differentiated differentiate VBN cord-302514-rstvf3mc 136 10 cells cell NNS cord-302514-rstvf3mc 136 11 such such JJ cord-302514-rstvf3mc 136 12 as as IN cord-302514-rstvf3mc 136 13 neurons neuron NNS cord-302514-rstvf3mc 136 14 , , , cord-302514-rstvf3mc 136 15 cardiomyocytes cardiomyocyte NNS cord-302514-rstvf3mc 136 16 , , , cord-302514-rstvf3mc 136 17 and and CC cord-302514-rstvf3mc 136 18 myofibers myofiber NNS cord-302514-rstvf3mc 136 19 . . . cord-302514-rstvf3mc 137 1 During during IN cord-302514-rstvf3mc 137 2 skeletal skeletal JJ cord-302514-rstvf3mc 137 3 muscle muscle NN cord-302514-rstvf3mc 137 4 development development NN cord-302514-rstvf3mc 137 5 , , , cord-302514-rstvf3mc 137 6 undifferentiated undifferentiated JJ cord-302514-rstvf3mc 137 7 myoblasts myoblast NNS cord-302514-rstvf3mc 137 8 are be VBP cord-302514-rstvf3mc 137 9 susceptible susceptible JJ cord-302514-rstvf3mc 137 10 to to IN cord-302514-rstvf3mc 137 11 serum serum NN cord-302514-rstvf3mc 137 12 deprived deprive VBN cord-302514-rstvf3mc 137 13 caspase caspase NN cord-302514-rstvf3mc 137 14 3-mediated 3-mediated CD cord-302514-rstvf3mc 137 15 apoptosis apoptosis NN cord-302514-rstvf3mc 137 16 but but CC cord-302514-rstvf3mc 137 17 become become VB cord-302514-rstvf3mc 137 18 resistant resistant JJ cord-302514-rstvf3mc 137 19 to to IN cord-302514-rstvf3mc 137 20 apoptosis apoptosis NN cord-302514-rstvf3mc 137 21 after after IN cord-302514-rstvf3mc 137 22 differentiating differentiate VBG cord-302514-rstvf3mc 137 23 into into IN cord-302514-rstvf3mc 137 24 myotubes myotube NNS cord-302514-rstvf3mc 137 25 . . . cord-302514-rstvf3mc 138 1 In in IN cord-302514-rstvf3mc 138 2 muscle muscle NN cord-302514-rstvf3mc 138 3 cells cell NNS cord-302514-rstvf3mc 138 4 , , , cord-302514-rstvf3mc 138 5 the the DT cord-302514-rstvf3mc 138 6 eEF1A1 eef1a1 NN cord-302514-rstvf3mc 138 7 is be VBZ cord-302514-rstvf3mc 138 8 expressed express VBN cord-302514-rstvf3mc 138 9 during during IN cord-302514-rstvf3mc 138 10 embryonic embryonic JJ cord-302514-rstvf3mc 138 11 development development NN cord-302514-rstvf3mc 138 12 of of IN cord-302514-rstvf3mc 138 13 myoblast myoblast NNP cord-302514-rstvf3mc 138 14 but but CC cord-302514-rstvf3mc 138 15 is be VBZ cord-302514-rstvf3mc 138 16 replaced replace VBN cord-302514-rstvf3mc 138 17 by by IN cord-302514-rstvf3mc 138 18 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 138 19 after after IN cord-302514-rstvf3mc 138 20 2 2 CD cord-302514-rstvf3mc 138 21 weeks week NNS cord-302514-rstvf3mc 138 22 of of IN cord-302514-rstvf3mc 138 23 birth birth NN cord-302514-rstvf3mc 138 24 indicating indicate VBG cord-302514-rstvf3mc 138 25 that that IN cord-302514-rstvf3mc 138 26 the the DT cord-302514-rstvf3mc 138 27 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 138 28 isoform isoform NN cord-302514-rstvf3mc 138 29 plays play VBZ cord-302514-rstvf3mc 138 30 a a DT cord-302514-rstvf3mc 138 31 pro pro JJ cord-302514-rstvf3mc 138 32 - - JJ cord-302514-rstvf3mc 138 33 apoptotic apoptotic JJ cord-302514-rstvf3mc 138 34 role role NN cord-302514-rstvf3mc 138 35 while while IN cord-302514-rstvf3mc 138 36 the the DT cord-302514-rstvf3mc 138 37 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 138 38 isoform isoform NN cord-302514-rstvf3mc 138 39 displays display VBZ cord-302514-rstvf3mc 138 40 anti anti JJ cord-302514-rstvf3mc 138 41 - - JJ cord-302514-rstvf3mc 138 42 apoptotic apoptotic JJ cord-302514-rstvf3mc 138 43 properties property NNS cord-302514-rstvf3mc 138 44 ( ( -LRB- cord-302514-rstvf3mc 138 45 85 85 CD cord-302514-rstvf3mc 138 46 , , , cord-302514-rstvf3mc 138 47 86 86 CD cord-302514-rstvf3mc 138 48 ) ) -RRB- cord-302514-rstvf3mc 138 49 . . . cord-302514-rstvf3mc 139 1 The the DT cord-302514-rstvf3mc 139 2 eEF1A eef1a NN cord-302514-rstvf3mc 139 3 proteins protein NNS cord-302514-rstvf3mc 139 4 play play VBP cord-302514-rstvf3mc 139 5 a a DT cord-302514-rstvf3mc 139 6 critical critical JJ cord-302514-rstvf3mc 139 7 role role NN cord-302514-rstvf3mc 139 8 in in IN cord-302514-rstvf3mc 139 9 several several JJ cord-302514-rstvf3mc 139 10 viral viral JJ cord-302514-rstvf3mc 139 11 infections infection NNS cord-302514-rstvf3mc 139 12 at at IN cord-302514-rstvf3mc 139 13 distinct distinct JJ cord-302514-rstvf3mc 139 14 stages stage NNS cord-302514-rstvf3mc 139 15 of of IN cord-302514-rstvf3mc 139 16 the the DT cord-302514-rstvf3mc 139 17 viral viral JJ cord-302514-rstvf3mc 139 18 cycle cycle NN cord-302514-rstvf3mc 139 19 [ [ -LRB- cord-302514-rstvf3mc 139 20 reviewed review VBN cord-302514-rstvf3mc 139 21 in in IN cord-302514-rstvf3mc 139 22 Ref Ref NNP cord-302514-rstvf3mc 139 23 . . . cord-302514-rstvf3mc 140 1 ( ( -LRB- cord-302514-rstvf3mc 140 2 87 87 CD cord-302514-rstvf3mc 140 3 ) ) -RRB- cord-302514-rstvf3mc 140 4 ] ] -RRB- cord-302514-rstvf3mc 141 1 ( ( -LRB- cord-302514-rstvf3mc 141 2 Table table NN cord-302514-rstvf3mc 141 3 3 3 CD cord-302514-rstvf3mc 141 4 ) ) -RRB- cord-302514-rstvf3mc 141 5 . . . cord-302514-rstvf3mc 142 1 Among among IN cord-302514-rstvf3mc 142 2 the the DT cord-302514-rstvf3mc 142 3 most most RBS cord-302514-rstvf3mc 142 4 studied study VBN cord-302514-rstvf3mc 142 5 viruses virus NNS cord-302514-rstvf3mc 142 6 , , , cord-302514-rstvf3mc 142 7 human human JJ cord-302514-rstvf3mc 142 8 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 142 9 virus virus NN cord-302514-rstvf3mc 142 10 ( ( -LRB- cord-302514-rstvf3mc 142 11 HIV HIV NNP cord-302514-rstvf3mc 142 12 ) ) -RRB- cord-302514-rstvf3mc 142 13 interacts interact VBZ cord-302514-rstvf3mc 142 14 with with IN cord-302514-rstvf3mc 142 15 numerous numerous JJ cord-302514-rstvf3mc 142 16 cellular cellular JJ cord-302514-rstvf3mc 142 17 proteins protein NNS cord-302514-rstvf3mc 142 18 , , , cord-302514-rstvf3mc 142 19 including include VBG cord-302514-rstvf3mc 142 20 eEF1A eef1a NN cord-302514-rstvf3mc 142 21 ( ( -LRB- cord-302514-rstvf3mc 142 22 88 88 CD cord-302514-rstvf3mc 142 23 ) ) -RRB- cord-302514-rstvf3mc 142 24 . . . cord-302514-rstvf3mc 143 1 First first RB cord-302514-rstvf3mc 143 2 , , , cord-302514-rstvf3mc 143 3 eEF1A eEF1A '' cord-302514-rstvf3mc 143 4 has have VBZ cord-302514-rstvf3mc 143 5 been be VBN cord-302514-rstvf3mc 143 6 detected detect VBN cord-302514-rstvf3mc 143 7 as as IN cord-302514-rstvf3mc 143 8 part part NN cord-302514-rstvf3mc 143 9 of of IN cord-302514-rstvf3mc 143 10 the the DT cord-302514-rstvf3mc 143 11 HIV HIV NNP cord-302514-rstvf3mc 143 12 virions virion NNS cord-302514-rstvf3mc 143 13 as as IN cord-302514-rstvf3mc 143 14 an an DT cord-302514-rstvf3mc 143 15 actin actin NN cord-302514-rstvf3mc 143 16 - - HYPH cord-302514-rstvf3mc 143 17 binding bind VBG cord-302514-rstvf3mc 143 18 protein protein NN cord-302514-rstvf3mc 143 19 ( ( -LRB- cord-302514-rstvf3mc 143 20 89 89 CD cord-302514-rstvf3mc 143 21 ) ) -RRB- cord-302514-rstvf3mc 143 22 . . . cord-302514-rstvf3mc 144 1 Second second RB cord-302514-rstvf3mc 144 2 , , , cord-302514-rstvf3mc 144 3 eEF1A eEF1A '' cord-302514-rstvf3mc 144 4 has have VBZ cord-302514-rstvf3mc 144 5 been be VBN cord-302514-rstvf3mc 144 6 reported report VBN cord-302514-rstvf3mc 144 7 to to TO cord-302514-rstvf3mc 144 8 plays play VBZ cord-302514-rstvf3mc 144 9 a a DT cord-302514-rstvf3mc 144 10 critical critical JJ cord-302514-rstvf3mc 144 11 role role NN cord-302514-rstvf3mc 144 12 at at IN cord-302514-rstvf3mc 144 13 early early JJ cord-302514-rstvf3mc 144 14 stages stage NNS cord-302514-rstvf3mc 144 15 of of IN cord-302514-rstvf3mc 144 16 HIV HIV NNP cord-302514-rstvf3mc 144 17 replication replication NN cord-302514-rstvf3mc 144 18 ( ( -LRB- cord-302514-rstvf3mc 144 19 Figure figure NN cord-302514-rstvf3mc 144 20 5 5 CD cord-302514-rstvf3mc 144 21 ) ) -RRB- cord-302514-rstvf3mc 144 22 . . . cord-302514-rstvf3mc 145 1 eEF1A eef1a UH cord-302514-rstvf3mc 145 2 and and CC cord-302514-rstvf3mc 145 3 also also RB cord-302514-rstvf3mc 145 4 EF1 ef1 VBP cord-302514-rstvf3mc 145 5 G g NN cord-302514-rstvf3mc 145 6 are be VBP cord-302514-rstvf3mc 145 7 part part NN cord-302514-rstvf3mc 145 8 of of IN cord-302514-rstvf3mc 145 9 HIV HIV NNP cord-302514-rstvf3mc 145 10 reverse reverse NN cord-302514-rstvf3mc 145 11 transcription transcription NN cord-302514-rstvf3mc 145 12 complex complex NN cord-302514-rstvf3mc 145 13 ( ( -LRB- cord-302514-rstvf3mc 145 14 RTC RTC NNP cord-302514-rstvf3mc 145 15 ) ) -RRB- cord-302514-rstvf3mc 145 16 ( ( -LRB- cord-302514-rstvf3mc 145 17 90 90 CD cord-302514-rstvf3mc 145 18 ) ) -RRB- cord-302514-rstvf3mc 145 19 . . . cord-302514-rstvf3mc 146 1 Both both DT cord-302514-rstvf3mc 146 2 eEF1A eef1a CD cord-302514-rstvf3mc 146 3 and and CC cord-302514-rstvf3mc 146 4 EF1 EF1 NNP cord-302514-rstvf3mc 146 5 G g NN cord-302514-rstvf3mc 146 6 proteins protein NNS cord-302514-rstvf3mc 146 7 coimmunoprecipitated coimmunoprecipitate VBN cord-302514-rstvf3mc 146 8 with with IN cord-302514-rstvf3mc 146 9 the the DT cord-302514-rstvf3mc 146 10 p51 p51 NN cord-302514-rstvf3mc 146 11 subunit subunit NN cord-302514-rstvf3mc 146 12 of of IN cord-302514-rstvf3mc 146 13 reverse reverse JJ cord-302514-rstvf3mc 146 14 transcriptase transcriptase NN cord-302514-rstvf3mc 146 15 ( ( -LRB- cord-302514-rstvf3mc 146 16 RT RT NNP cord-302514-rstvf3mc 146 17 ) ) -RRB- cord-302514-rstvf3mc 146 18 and and CC cord-302514-rstvf3mc 146 19 integrase integrase NN cord-302514-rstvf3mc 146 20 using use VBG cord-302514-rstvf3mc 146 21 an an DT cord-302514-rstvf3mc 146 22 endogenous endogenous JJ cord-302514-rstvf3mc 146 23 reverse reverse NN cord-302514-rstvf3mc 146 24 transcription transcription NN cord-302514-rstvf3mc 146 25 assay assay NN cord-302514-rstvf3mc 146 26 ( ( -LRB- cord-302514-rstvf3mc 146 27 90 90 CD cord-302514-rstvf3mc 146 28 ) ) -RRB- cord-302514-rstvf3mc 146 29 ( ( -LRB- cord-302514-rstvf3mc 146 30 Figure figure NN cord-302514-rstvf3mc 146 31 5 5 CD cord-302514-rstvf3mc 146 32 ) ) -RRB- cord-302514-rstvf3mc 146 33 . . . cord-302514-rstvf3mc 147 1 The the DT cord-302514-rstvf3mc 147 2 depletion depletion NN cord-302514-rstvf3mc 147 3 of of IN cord-302514-rstvf3mc 147 4 eEF1A eef1a CD cord-302514-rstvf3mc 147 5 and and CC cord-302514-rstvf3mc 147 6 EF1 ef1 NN cord-302514-rstvf3mc 147 7 G G NNP cord-302514-rstvf3mc 147 8 using use VBG cord-302514-rstvf3mc 147 9 siRNAs siRNAs NNP cord-302514-rstvf3mc 147 10 decreased decrease VBD cord-302514-rstvf3mc 147 11 reverse reverse NN cord-302514-rstvf3mc 147 12 transcription transcription NN cord-302514-rstvf3mc 147 13 parallel parallel NN cord-302514-rstvf3mc 147 14 to to IN cord-302514-rstvf3mc 147 15 reduced reduced JJ cord-302514-rstvf3mc 147 16 levels level NNS cord-302514-rstvf3mc 147 17 of of IN cord-302514-rstvf3mc 147 18 RTC RTC NNP cord-302514-rstvf3mc 147 19 in in IN cord-302514-rstvf3mc 147 20 treated treat VBN cord-302514-rstvf3mc 147 21 cells cell NNS cord-302514-rstvf3mc 147 22 ( ( -LRB- cord-302514-rstvf3mc 147 23 90 90 CD cord-302514-rstvf3mc 147 24 ) ) -RRB- cord-302514-rstvf3mc 147 25 . . . cord-302514-rstvf3mc 148 1 Since since IN cord-302514-rstvf3mc 148 2 integrase integrase NN cord-302514-rstvf3mc 148 3 is be VBZ cord-302514-rstvf3mc 148 4 also also RB cord-302514-rstvf3mc 148 5 an an DT cord-302514-rstvf3mc 148 6 RT RT NNP cord-302514-rstvf3mc 148 7 binding bind VBG cord-302514-rstvf3mc 148 8 protein protein NN cord-302514-rstvf3mc 148 9 , , , cord-302514-rstvf3mc 148 10 a a DT cord-302514-rstvf3mc 148 11 tight tight JJ cord-302514-rstvf3mc 148 12 interplay interplay NN cord-302514-rstvf3mc 148 13 between between IN cord-302514-rstvf3mc 148 14 RT RT NNP cord-302514-rstvf3mc 148 15 , , , cord-302514-rstvf3mc 148 16 integrase integrase NN cord-302514-rstvf3mc 148 17 , , , cord-302514-rstvf3mc 148 18 and and CC cord-302514-rstvf3mc 148 19 eEF1A eef1a NN cord-302514-rstvf3mc 148 20 could could MD cord-302514-rstvf3mc 148 21 be be VB cord-302514-rstvf3mc 148 22 involved involve VBN cord-302514-rstvf3mc 148 23 in in IN cord-302514-rstvf3mc 148 24 several several JJ cord-302514-rstvf3mc 148 25 stages stage NNS cord-302514-rstvf3mc 148 26 of of IN cord-302514-rstvf3mc 148 27 HIV HIV NNP cord-302514-rstvf3mc 148 28 replication replication NN cord-302514-rstvf3mc 148 29 . . . cord-302514-rstvf3mc 149 1 Actually actually RB cord-302514-rstvf3mc 149 2 , , , cord-302514-rstvf3mc 149 3 integrase integrase NNP cord-302514-rstvf3mc 149 4 has have VBZ cord-302514-rstvf3mc 149 5 been be VBN cord-302514-rstvf3mc 149 6 shown show VBN cord-302514-rstvf3mc 149 7 to to TO cord-302514-rstvf3mc 149 8 interact interact VB cord-302514-rstvf3mc 149 9 with with IN cord-302514-rstvf3mc 149 10 eEF1A eef1a CD cord-302514-rstvf3mc 150 1 in in IN cord-302514-rstvf3mc 150 2 vitro vitro FW cord-302514-rstvf3mc 150 3 ( ( -LRB- cord-302514-rstvf3mc 150 4 91 91 CD cord-302514-rstvf3mc 150 5 , , , cord-302514-rstvf3mc 150 6 92 92 CD cord-302514-rstvf3mc 150 7 ) ) -RRB- cord-302514-rstvf3mc 150 8 . . . cord-302514-rstvf3mc 150 9 eEF1A eef1a NN cord-302514-rstvf3mc 150 10 also also RB cord-302514-rstvf3mc 150 11 interacts interact VBZ cord-302514-rstvf3mc 150 12 with with IN cord-302514-rstvf3mc 150 13 other other JJ cord-302514-rstvf3mc 150 14 viral viral JJ cord-302514-rstvf3mc 150 15 proteins protein NNS cord-302514-rstvf3mc 150 16 involved involve VBN cord-302514-rstvf3mc 150 17 in in IN cord-302514-rstvf3mc 150 18 early early JJ cord-302514-rstvf3mc 150 19 stages stage NNS cord-302514-rstvf3mc 150 20 of of IN cord-302514-rstvf3mc 150 21 HIV HIV NNP cord-302514-rstvf3mc 150 22 replication replication NN cord-302514-rstvf3mc 150 23 such such JJ cord-302514-rstvf3mc 150 24 as as IN cord-302514-rstvf3mc 150 25 Nef Nef NNP cord-302514-rstvf3mc 150 26 and and CC cord-302514-rstvf3mc 150 27 Tat Tat NNP cord-302514-rstvf3mc 150 28 . . . cord-302514-rstvf3mc 151 1 Several several JJ cord-302514-rstvf3mc 151 2 reports report NNS cord-302514-rstvf3mc 151 3 indicate indicate VBP cord-302514-rstvf3mc 151 4 that that IN cord-302514-rstvf3mc 151 5 HIV HIV NNP cord-302514-rstvf3mc 151 6 Nef Nef NNP cord-302514-rstvf3mc 151 7 interacts interact VBZ cord-302514-rstvf3mc 151 8 with with IN cord-302514-rstvf3mc 151 9 eEF1A eef1a CD cord-302514-rstvf3mc 151 10 ( ( -LRB- cord-302514-rstvf3mc 151 11 77 77 CD cord-302514-rstvf3mc 151 12 , , , cord-302514-rstvf3mc 151 13 93 93 CD cord-302514-rstvf3mc 151 14 ) ) -RRB- cord-302514-rstvf3mc 152 1 ( ( -LRB- cord-302514-rstvf3mc 152 2 Figure figure NN cord-302514-rstvf3mc 152 3 5 5 CD cord-302514-rstvf3mc 152 4 ) ) -RRB- cord-302514-rstvf3mc 152 5 . . . cord-302514-rstvf3mc 153 1 Abbas Abbas NNP cord-302514-rstvf3mc 153 2 and and CC cord-302514-rstvf3mc 153 3 colleagues colleague NNS cord-302514-rstvf3mc 153 4 have have VBP cord-302514-rstvf3mc 153 5 shown show VBN cord-302514-rstvf3mc 153 6 that that IN cord-302514-rstvf3mc 153 7 the the DT cord-302514-rstvf3mc 153 8 Nef Nef NNP cord-302514-rstvf3mc 153 9 - - HYPH cord-302514-rstvf3mc 153 10 eEF1A eef1a CD cord-302514-rstvf3mc 153 11 interaction interaction NN cord-302514-rstvf3mc 153 12 favors favor VBZ cord-302514-rstvf3mc 153 13 the the DT cord-302514-rstvf3mc 153 14 nucleo nucleo JJ cord-302514-rstvf3mc 153 15 - - JJ cord-302514-rstvf3mc 153 16 cytoplasmic cytoplasmic JJ cord-302514-rstvf3mc 153 17 shuttling shuttling NN cord-302514-rstvf3mc 153 18 of of IN cord-302514-rstvf3mc 153 19 eEF1A eef1a CD cord-302514-rstvf3mc 153 20 and and CC cord-302514-rstvf3mc 153 21 ultimately ultimately RB cord-302514-rstvf3mc 153 22 inhibits inhibit VBZ cord-302514-rstvf3mc 153 23 stress stress NN cord-302514-rstvf3mc 153 24 - - HYPH cord-302514-rstvf3mc 153 25 mediated mediate VBN cord-302514-rstvf3mc 153 26 apoptosis apoptosis NN cord-302514-rstvf3mc 153 27 in in IN cord-302514-rstvf3mc 153 28 monocyte monocyte NNP cord-302514-rstvf3mc 153 29 - - HYPH cord-302514-rstvf3mc 153 30 derived derive VBN cord-302514-rstvf3mc 153 31 macrophages macrophage NNS cord-302514-rstvf3mc 153 32 ( ( -LRB- cord-302514-rstvf3mc 153 33 77 77 CD cord-302514-rstvf3mc 153 34 ) ) -RRB- cord-302514-rstvf3mc 153 35 . . . cord-302514-rstvf3mc 154 1 Additionally additionally RB cord-302514-rstvf3mc 154 2 , , , cord-302514-rstvf3mc 154 3 Nef Nef NNP cord-302514-rstvf3mc 154 4 interaction interaction NN cord-302514-rstvf3mc 154 5 with with IN cord-302514-rstvf3mc 154 6 actin actin NN cord-302514-rstvf3mc 154 7 impairs impair VBZ cord-302514-rstvf3mc 154 8 human human JJ cord-302514-rstvf3mc 154 9 podocyte podocyte NNP cord-302514-rstvf3mc 154 10 actin actin NNP cord-302514-rstvf3mc 154 11 cytoskeletal cytoskeletal JJ cord-302514-rstvf3mc 154 12 integrity integrity NN cord-302514-rstvf3mc 154 13 and and CC cord-302514-rstvf3mc 154 14 eEF1A eef1a NN cord-302514-rstvf3mc 154 15 could could MD cord-302514-rstvf3mc 154 16 play play VB cord-302514-rstvf3mc 154 17 a a DT cord-302514-rstvf3mc 154 18 role role NN cord-302514-rstvf3mc 154 19 in in IN cord-302514-rstvf3mc 154 20 the the DT cord-302514-rstvf3mc 154 21 development development NN cord-302514-rstvf3mc 154 22 of of IN cord-302514-rstvf3mc 154 23 podocyte podocyte NNP cord-302514-rstvf3mc 154 24 phenotype phenotype NN cord-302514-rstvf3mc 154 25 in in IN cord-302514-rstvf3mc 154 26 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 154 27 associated associate VBD cord-302514-rstvf3mc 154 28 nephropathy nephropathy NN cord-302514-rstvf3mc 154 29 ( ( -LRB- cord-302514-rstvf3mc 154 30 93 93 CD cord-302514-rstvf3mc 154 31 ) ) -RRB- cord-302514-rstvf3mc 154 32 . . . cord-302514-rstvf3mc 155 1 The the DT cord-302514-rstvf3mc 155 2 trans trans JJ cord-302514-rstvf3mc 155 3 - - JJ cord-302514-rstvf3mc 155 4 activation activation JJ cord-302514-rstvf3mc 155 5 response response NN cord-302514-rstvf3mc 155 6 ( ( -LRB- cord-302514-rstvf3mc 155 7 TAR tar NN cord-302514-rstvf3mc 155 8 ) ) -RRB- cord-302514-rstvf3mc 155 9 element element NN cord-302514-rstvf3mc 155 10 is be VBZ cord-302514-rstvf3mc 155 11 critical critical JJ cord-302514-rstvf3mc 155 12 for for IN cord-302514-rstvf3mc 155 13 the the DT cord-302514-rstvf3mc 155 14 activation activation NN cord-302514-rstvf3mc 155 15 of of IN cord-302514-rstvf3mc 155 16 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 155 17 transcription transcription NN cord-302514-rstvf3mc 155 18 . . . cord-302514-rstvf3mc 156 1 eEF1A eef1a NN cord-302514-rstvf3mc 156 2 stimulates stimulate VBZ cord-302514-rstvf3mc 156 3 the the DT cord-302514-rstvf3mc 156 4 RNA RNA NNP cord-302514-rstvf3mc 156 5 polymerase polymerase NN cord-302514-rstvf3mc 156 6 II II NNP cord-302514-rstvf3mc 156 7 and and CC cord-302514-rstvf3mc 156 8 TRP-185 trp-185 DT cord-302514-rstvf3mc 156 9 binding bind VBG cord-302514-rstvf3mc 156 10 to to IN cord-302514-rstvf3mc 156 11 TAR TAR NNP cord-302514-rstvf3mc 156 12 RNA RNA NNP cord-302514-rstvf3mc 156 13 , , , cord-302514-rstvf3mc 156 14 which which WDT cord-302514-rstvf3mc 156 15 in in IN cord-302514-rstvf3mc 156 16 turn turn NN cord-302514-rstvf3mc 156 17 regulates regulate VBZ cord-302514-rstvf3mc 156 18 the the DT cord-302514-rstvf3mc 156 19 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 156 20 gene gene NN cord-302514-rstvf3mc 156 21 expression expression NN cord-302514-rstvf3mc 156 22 ( ( -LRB- cord-302514-rstvf3mc 156 23 94 94 CD cord-302514-rstvf3mc 156 24 ) ) -RRB- cord-302514-rstvf3mc 156 25 . . . cord-302514-rstvf3mc 157 1 eEF1A eef1a NN cord-302514-rstvf3mc 157 2 has have VBZ cord-302514-rstvf3mc 157 3 been be VBN cord-302514-rstvf3mc 157 4 described describe VBN cord-302514-rstvf3mc 157 5 to to TO cord-302514-rstvf3mc 157 6 interact interact VB cord-302514-rstvf3mc 157 7 with with IN cord-302514-rstvf3mc 157 8 the the DT cord-302514-rstvf3mc 157 9 HIV HIV NNP cord-302514-rstvf3mc 157 10 Gag Gag NNP cord-302514-rstvf3mc 157 11 protein protein NN cord-302514-rstvf3mc 157 12 ( ( -LRB- cord-302514-rstvf3mc 157 13 88 88 CD cord-302514-rstvf3mc 157 14 ) ) -RRB- cord-302514-rstvf3mc 157 15 . . . cord-302514-rstvf3mc 158 1 Finally finally RB cord-302514-rstvf3mc 158 2 , , , cord-302514-rstvf3mc 158 3 eEF1A eEF1A '' cord-302514-rstvf3mc 158 4 is be VBZ cord-302514-rstvf3mc 158 5 responsible responsible JJ cord-302514-rstvf3mc 158 6 for for IN cord-302514-rstvf3mc 158 7 the the DT cord-302514-rstvf3mc 158 8 selection selection NN cord-302514-rstvf3mc 158 9 and and CC cord-302514-rstvf3mc 158 10 binding binding NN cord-302514-rstvf3mc 158 11 of of IN cord-302514-rstvf3mc 158 12 cognate cognate JJ cord-302514-rstvf3mc 158 13 aminoacyl aminoacyl NNS cord-302514-rstvf3mc 158 14 - - : cord-302514-rstvf3mc 158 15 tRNAs trna NNS cord-302514-rstvf3mc 158 16 to to IN cord-302514-rstvf3mc 158 17 the the DT cord-302514-rstvf3mc 158 18 A a DT cord-302514-rstvf3mc 158 19 site site NN cord-302514-rstvf3mc 158 20 of of IN cord-302514-rstvf3mc 158 21 the the DT cord-302514-rstvf3mc 158 22 ribosome ribosome NN cord-302514-rstvf3mc 158 23 . . . cord-302514-rstvf3mc 159 1 HIV HIV NNP cord-302514-rstvf3mc 159 2 Nef Nef NNP cord-302514-rstvf3mc 159 3 interacts interact VBZ cord-302514-rstvf3mc 159 4 with with IN cord-302514-rstvf3mc 159 5 two two CD cord-302514-rstvf3mc 159 6 components component NNS cord-302514-rstvf3mc 159 7 of of IN cord-302514-rstvf3mc 159 8 the the DT cord-302514-rstvf3mc 159 9 40S 40s CD cord-302514-rstvf3mc 159 10 small small JJ cord-302514-rstvf3mc 159 11 ribosomal ribosomal JJ cord-302514-rstvf3mc 159 12 subunit subunit NN cord-302514-rstvf3mc 159 13 , , , cord-302514-rstvf3mc 159 14 the the DT cord-302514-rstvf3mc 159 15 RPS10 RPS10 NNP cord-302514-rstvf3mc 159 16 protein protein NN cord-302514-rstvf3mc 159 17 , , , cord-302514-rstvf3mc 159 18 and and CC cord-302514-rstvf3mc 159 19 the the DT cord-302514-rstvf3mc 159 20 18S 18S NNPS cord-302514-rstvf3mc 159 21 rRNA rRNA NNP cord-302514-rstvf3mc 159 22 , , , cord-302514-rstvf3mc 159 23 and and CC cord-302514-rstvf3mc 159 24 also also RB cord-302514-rstvf3mc 159 25 to to IN cord-302514-rstvf3mc 159 26 tRNAs trnas ADD cord-302514-rstvf3mc 159 27 , , , cord-302514-rstvf3mc 159 28 and and CC cord-302514-rstvf3mc 159 29 has have VBZ cord-302514-rstvf3mc 159 30 been be VBN cord-302514-rstvf3mc 159 31 reported report VBN cord-302514-rstvf3mc 159 32 to to TO cord-302514-rstvf3mc 159 33 decrease decrease VB cord-302514-rstvf3mc 159 34 translation translation NN cord-302514-rstvf3mc 159 35 using use VBG cord-302514-rstvf3mc 159 36 an an DT cord-302514-rstvf3mc 159 37 in in FW cord-302514-rstvf3mc 159 38 vitro vitro FW cord-302514-rstvf3mc 159 39 translation translation NN cord-302514-rstvf3mc 159 40 assay assay NN cord-302514-rstvf3mc 159 41 ( ( -LRB- cord-302514-rstvf3mc 159 42 95 95 CD cord-302514-rstvf3mc 159 43 ) ) -RRB- cord-302514-rstvf3mc 159 44 . . . cord-302514-rstvf3mc 160 1 We -PRON- PRP cord-302514-rstvf3mc 160 2 can can MD cord-302514-rstvf3mc 160 3 not not RB cord-302514-rstvf3mc 160 4 exclude exclude VB cord-302514-rstvf3mc 160 5 that that IN cord-302514-rstvf3mc 160 6 eEF1A eef1a NN cord-302514-rstvf3mc 160 7 that that WDT cord-302514-rstvf3mc 160 8 binds bind VBZ cord-302514-rstvf3mc 160 9 to to IN cord-302514-rstvf3mc 160 10 both both CC cord-302514-rstvf3mc 160 11 Nef Nef NNP cord-302514-rstvf3mc 160 12 and and CC cord-302514-rstvf3mc 160 13 tRNA tRNA NNP cord-302514-rstvf3mc 160 14 participates participate VBZ cord-302514-rstvf3mc 160 15 in in IN cord-302514-rstvf3mc 160 16 the the DT cord-302514-rstvf3mc 160 17 control control NN cord-302514-rstvf3mc 160 18 of of IN cord-302514-rstvf3mc 160 19 translation translation NN cord-302514-rstvf3mc 160 20 in in IN cord-302514-rstvf3mc 160 21 HIV HIV NNP cord-302514-rstvf3mc 160 22 - - HYPH cord-302514-rstvf3mc 160 23 infected infect VBN cord-302514-rstvf3mc 160 24 cells cell NNS cord-302514-rstvf3mc 160 25 . . . cord-302514-rstvf3mc 161 1 Interestingly interestingly RB cord-302514-rstvf3mc 161 2 , , , cord-302514-rstvf3mc 161 3 EF1-delta EF1-delta NNP cord-302514-rstvf3mc 161 4 has have VBZ cord-302514-rstvf3mc 161 5 been be VBN cord-302514-rstvf3mc 161 6 reported report VBN cord-302514-rstvf3mc 161 7 to to TO cord-302514-rstvf3mc 161 8 interact interact VB cord-302514-rstvf3mc 161 9 with with IN cord-302514-rstvf3mc 161 10 the the DT cord-302514-rstvf3mc 161 11 second second JJ cord-302514-rstvf3mc 161 12 coding coding NN cord-302514-rstvf3mc 161 13 exon exon NN cord-302514-rstvf3mc 161 14 of of IN cord-302514-rstvf3mc 161 15 HIV HIV NNP cord-302514-rstvf3mc 161 16 Tat Tat NNP cord-302514-rstvf3mc 161 17 , , , cord-302514-rstvf3mc 161 18 and and CC cord-302514-rstvf3mc 161 19 to to TO cord-302514-rstvf3mc 161 20 result result VB cord-302514-rstvf3mc 161 21 in in IN cord-302514-rstvf3mc 161 22 reduced reduce VBN cord-302514-rstvf3mc 161 23 efficiency efficiency NN cord-302514-rstvf3mc 161 24 of of IN cord-302514-rstvf3mc 161 25 the the DT cord-302514-rstvf3mc 161 26 translation translation NN cord-302514-rstvf3mc 161 27 of of IN cord-302514-rstvf3mc 161 28 cellular cellular JJ cord-302514-rstvf3mc 161 29 proteins protein NNS cord-302514-rstvf3mc 161 30 , , , cord-302514-rstvf3mc 161 31 but but CC cord-302514-rstvf3mc 161 32 not not RB cord-302514-rstvf3mc 161 33 of of IN cord-302514-rstvf3mc 161 34 viral viral JJ cord-302514-rstvf3mc 161 35 mRNAs mrna NNS cord-302514-rstvf3mc 161 36 ( ( -LRB- cord-302514-rstvf3mc 161 37 96 96 CD cord-302514-rstvf3mc 161 38 ) ) -RRB- cord-302514-rstvf3mc 161 39 . . . cord-302514-rstvf3mc 162 1 Since since IN cord-302514-rstvf3mc 162 2 overexpression overexpression NN cord-302514-rstvf3mc 162 3 of of IN cord-302514-rstvf3mc 162 4 eEF1A eef1a NN cord-302514-rstvf3mc 162 5 has have VBZ cord-302514-rstvf3mc 162 6 been be VBN cord-302514-rstvf3mc 162 7 reported report VBN cord-302514-rstvf3mc 162 8 in in IN cord-302514-rstvf3mc 162 9 several several JJ cord-302514-rstvf3mc 162 10 cancers cancer NNS cord-302514-rstvf3mc 162 11 , , , cord-302514-rstvf3mc 162 12 we -PRON- PRP cord-302514-rstvf3mc 162 13 can can MD cord-302514-rstvf3mc 162 14 not not RB cord-302514-rstvf3mc 162 15 exclude exclude VB cord-302514-rstvf3mc 162 16 a a DT cord-302514-rstvf3mc 162 17 link link NN cord-302514-rstvf3mc 162 18 between between IN cord-302514-rstvf3mc 162 19 oncoviruses oncoviruse NNS cord-302514-rstvf3mc 162 20 and and CC cord-302514-rstvf3mc 162 21 eEF1A. eEF1A. NNP cord-302514-rstvf3mc 163 1 Among among IN cord-302514-rstvf3mc 163 2 oncoviruses oncoviruse NNS cord-302514-rstvf3mc 163 3 , , , cord-302514-rstvf3mc 163 4 hepatitis hepatitis NN cord-302514-rstvf3mc 163 5 B B NNP cord-302514-rstvf3mc 163 6 virus virus NN cord-302514-rstvf3mc 163 7 expresses express VBZ cord-302514-rstvf3mc 163 8 the the DT cord-302514-rstvf3mc 163 9 HBx hbx NN cord-302514-rstvf3mc 163 10 protein protein NN cord-302514-rstvf3mc 163 11 that that WDT cord-302514-rstvf3mc 163 12 has have VBZ cord-302514-rstvf3mc 163 13 been be VBN cord-302514-rstvf3mc 163 14 previously previously RB cord-302514-rstvf3mc 163 15 involved involve VBN cord-302514-rstvf3mc 163 16 in in IN cord-302514-rstvf3mc 163 17 liver liver NN cord-302514-rstvf3mc 163 18 cancer cancer NN cord-302514-rstvf3mc 163 19 , , , cord-302514-rstvf3mc 163 20 especially especially RB cord-302514-rstvf3mc 163 21 HCC HCC NNP cord-302514-rstvf3mc 163 22 ( ( -LRB- cord-302514-rstvf3mc 163 23 110 110 CD cord-302514-rstvf3mc 163 24 ) ) -RRB- cord-302514-rstvf3mc 163 25 . . . cord-302514-rstvf3mc 164 1 HBx HBx NNP cord-302514-rstvf3mc 164 2 protein protein NN cord-302514-rstvf3mc 164 3 has have VBZ cord-302514-rstvf3mc 164 4 been be VBN cord-302514-rstvf3mc 164 5 reported report VBN cord-302514-rstvf3mc 164 6 to to TO cord-302514-rstvf3mc 164 7 interact interact VB cord-302514-rstvf3mc 164 8 with with IN cord-302514-rstvf3mc 164 9 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 164 10 in in IN cord-302514-rstvf3mc 164 11 Huh-7 Huh-7 NNP cord-302514-rstvf3mc 164 12 hepatoma hepatoma NN cord-302514-rstvf3mc 164 13 cells cell NNS cord-302514-rstvf3mc 164 14 infected infect VBN cord-302514-rstvf3mc 164 15 with with IN cord-302514-rstvf3mc 164 16 recombinant recombinant JJ cord-302514-rstvf3mc 164 17 adenovirus adenovirus NN cord-302514-rstvf3mc 164 18 expressing express VBG cord-302514-rstvf3mc 164 19 HBx HBx NNP cord-302514-rstvf3mc 164 20 protein protein NN cord-302514-rstvf3mc 164 21 ( ( -LRB- cord-302514-rstvf3mc 164 22 97 97 CD cord-302514-rstvf3mc 164 23 ) ) -RRB- cord-302514-rstvf3mc 164 24 . . . cord-302514-rstvf3mc 165 1 Interaction Interaction NNP cord-302514-rstvf3mc 165 2 of of IN cord-302514-rstvf3mc 165 3 HBx HBx NNP cord-302514-rstvf3mc 165 4 protein protein NN cord-302514-rstvf3mc 165 5 with with IN cord-302514-rstvf3mc 165 6 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 165 7 blocks block NNS cord-302514-rstvf3mc 165 8 filamentous filamentous JJ cord-302514-rstvf3mc 165 9 actin actin NN cord-302514-rstvf3mc 165 10 bundling bundling NN cord-302514-rstvf3mc 165 11 ( ( -LRB- cord-302514-rstvf3mc 165 12 97 97 CD cord-302514-rstvf3mc 165 13 ) ) -RRB- cord-302514-rstvf3mc 165 14 . . . cord-302514-rstvf3mc 166 1 Interestingly interestingly RB cord-302514-rstvf3mc 166 2 , , , cord-302514-rstvf3mc 166 3 the the DT cord-302514-rstvf3mc 166 4 hepatitis hepatitis NN cord-302514-rstvf3mc 166 5 delta delta NNP cord-302514-rstvf3mc 166 6 virus virus NN cord-302514-rstvf3mc 166 7 ( ( -LRB- cord-302514-rstvf3mc 166 8 HDV HDV NNP cord-302514-rstvf3mc 166 9 ) ) -RRB- cord-302514-rstvf3mc 166 10 that that WDT cord-302514-rstvf3mc 166 11 can can MD cord-302514-rstvf3mc 166 12 propagate propagate VB cord-302514-rstvf3mc 166 13 only only RB cord-302514-rstvf3mc 166 14 in in IN cord-302514-rstvf3mc 166 15 the the DT cord-302514-rstvf3mc 166 16 presence presence NN cord-302514-rstvf3mc 166 17 of of IN cord-302514-rstvf3mc 166 18 HBV HBV NNP cord-302514-rstvf3mc 166 19 has have VBZ cord-302514-rstvf3mc 166 20 a a DT cord-302514-rstvf3mc 166 21 RNA RNA NNP cord-302514-rstvf3mc 166 22 genome genome NN cord-302514-rstvf3mc 166 23 that that WDT cord-302514-rstvf3mc 166 24 also also RB cord-302514-rstvf3mc 166 25 interacts interact VBZ cord-302514-rstvf3mc 166 26 with with IN cord-302514-rstvf3mc 166 27 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 166 28 ( ( -LRB- cord-302514-rstvf3mc 166 29 98 98 CD cord-302514-rstvf3mc 166 30 ) ) -RRB- cord-302514-rstvf3mc 166 31 . . . cord-302514-rstvf3mc 167 1 A a DT cord-302514-rstvf3mc 167 2 dozen dozen NN cord-302514-rstvf3mc 167 3 of of IN cord-302514-rstvf3mc 167 4 human human JJ cord-302514-rstvf3mc 167 5 papillomavirus papillomavirus NN cord-302514-rstvf3mc 167 6 ( ( -LRB- cord-302514-rstvf3mc 167 7 HPV hpv NN cord-302514-rstvf3mc 167 8 ) ) -RRB- cord-302514-rstvf3mc 167 9 types type NNS cord-302514-rstvf3mc 167 10 including include VBG cord-302514-rstvf3mc 167 11 HPV16 hpv16 ADD cord-302514-rstvf3mc 167 12 and and CC cord-302514-rstvf3mc 167 13 HPV18 HPV18 NNP cord-302514-rstvf3mc 167 14 are be VBP cord-302514-rstvf3mc 167 15 well well RB cord-302514-rstvf3mc 167 16 - - HYPH cord-302514-rstvf3mc 167 17 known know VBN cord-302514-rstvf3mc 167 18 oncoviruses oncoviruse NNS cord-302514-rstvf3mc 167 19 that that WDT cord-302514-rstvf3mc 167 20 express express VBP cord-302514-rstvf3mc 167 21 two two CD cord-302514-rstvf3mc 167 22 oncoproteins oncoprotein NNS cord-302514-rstvf3mc 167 23 E6 E6 NNP cord-302514-rstvf3mc 167 24 and and CC cord-302514-rstvf3mc 167 25 E7 E7 NNP cord-302514-rstvf3mc 167 26 , , , cord-302514-rstvf3mc 167 27 and and CC cord-302514-rstvf3mc 167 28 favor favor VB cord-302514-rstvf3mc 167 29 cellular cellular JJ cord-302514-rstvf3mc 167 30 transformation transformation NN cord-302514-rstvf3mc 167 31 , , , cord-302514-rstvf3mc 167 32 oncogenesis oncogenesis NNP cord-302514-rstvf3mc 167 33 , , , cord-302514-rstvf3mc 167 34 and and CC cord-302514-rstvf3mc 167 35 the the DT cord-302514-rstvf3mc 167 36 appearance appearance NN cord-302514-rstvf3mc 167 37 of of IN cord-302514-rstvf3mc 167 38 cervical cervical JJ cord-302514-rstvf3mc 167 39 cancers cancer NNS cord-302514-rstvf3mc 167 40 ( ( -LRB- cord-302514-rstvf3mc 167 41 111 111 CD cord-302514-rstvf3mc 167 42 ) ) -RRB- cord-302514-rstvf3mc 167 43 . . . cord-302514-rstvf3mc 168 1 E7 E7 NNP cord-302514-rstvf3mc 168 2 protein protein NN cord-302514-rstvf3mc 168 3 of of IN cord-302514-rstvf3mc 168 4 HPV38 HPV38 NNP cord-302514-rstvf3mc 168 5 has have VBZ cord-302514-rstvf3mc 168 6 been be VBN cord-302514-rstvf3mc 168 7 shown show VBN cord-302514-rstvf3mc 168 8 to to TO cord-302514-rstvf3mc 168 9 interact interact VB cord-302514-rstvf3mc 168 10 with with IN cord-302514-rstvf3mc 168 11 both both CC cord-302514-rstvf3mc 168 12 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 168 13 and and CC cord-302514-rstvf3mc 168 14 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 168 15 proteins protein NNS cord-302514-rstvf3mc 168 16 leading lead VBG cord-302514-rstvf3mc 168 17 to to IN cord-302514-rstvf3mc 168 18 cellular cellular JJ cord-302514-rstvf3mc 168 19 immortalization immortalization NN cord-302514-rstvf3mc 168 20 and and CC cord-302514-rstvf3mc 168 21 transformation transformation NN cord-302514-rstvf3mc 168 22 of of IN cord-302514-rstvf3mc 168 23 primary primary JJ cord-302514-rstvf3mc 168 24 keratinocytes keratinocyte NNS cord-302514-rstvf3mc 168 25 probably probably RB cord-302514-rstvf3mc 168 26 through through IN cord-302514-rstvf3mc 168 27 disruption disruption NN cord-302514-rstvf3mc 168 28 of of IN cord-302514-rstvf3mc 168 29 actin actin NN cord-302514-rstvf3mc 168 30 stress stress NN cord-302514-rstvf3mc 168 31 fiber fiber NN cord-302514-rstvf3mc 168 32 formation formation NN cord-302514-rstvf3mc 168 33 , , , cord-302514-rstvf3mc 168 34 a a DT cord-302514-rstvf3mc 168 35 critical critical JJ cord-302514-rstvf3mc 168 36 event event NN cord-302514-rstvf3mc 168 37 linked link VBN cord-302514-rstvf3mc 168 38 to to IN cord-302514-rstvf3mc 168 39 tumor tumor NN cord-302514-rstvf3mc 168 40 formation formation NN cord-302514-rstvf3mc 168 41 ( ( -LRB- cord-302514-rstvf3mc 168 42 99 99 CD cord-302514-rstvf3mc 168 43 ) ) -RRB- cord-302514-rstvf3mc 168 44 . . . cord-302514-rstvf3mc 169 1 eEF1A eef1a NN cord-302514-rstvf3mc 169 2 facilitates facilitate VBZ cord-302514-rstvf3mc 169 3 virus virus NN cord-302514-rstvf3mc 169 4 replication replication NN cord-302514-rstvf3mc 169 5 complex complex NN cord-302514-rstvf3mc 169 6 ( ( -LRB- cord-302514-rstvf3mc 169 7 RPC RPC NNP cord-302514-rstvf3mc 169 8 ) ) -RRB- cord-302514-rstvf3mc 169 9 assembly assembly NN cord-302514-rstvf3mc 169 10 and and CC cord-302514-rstvf3mc 169 11 favors favor VBZ cord-302514-rstvf3mc 169 12 replication replication NN cord-302514-rstvf3mc 169 13 of of IN cord-302514-rstvf3mc 169 14 West West NNP cord-302514-rstvf3mc 169 15 Nile Nile NNP cord-302514-rstvf3mc 169 16 virus virus NN cord-302514-rstvf3mc 169 17 and and CC cord-302514-rstvf3mc 169 18 dengue dengue NN cord-302514-rstvf3mc 169 19 virus virus NN cord-302514-rstvf3mc 169 20 ( ( -LRB- cord-302514-rstvf3mc 169 21 100 100 CD cord-302514-rstvf3mc 169 22 ) ) -RRB- cord-302514-rstvf3mc 169 23 ( ( -LRB- cord-302514-rstvf3mc 169 24 101 101 CD cord-302514-rstvf3mc 169 25 ) ) -RRB- cord-302514-rstvf3mc 169 26 ( ( -LRB- cord-302514-rstvf3mc 169 27 102 102 CD cord-302514-rstvf3mc 169 28 ) ) -RRB- cord-302514-rstvf3mc 169 29 . . . cord-302514-rstvf3mc 170 1 Similarly similarly RB cord-302514-rstvf3mc 170 2 , , , cord-302514-rstvf3mc 170 3 eEF1A eEF1A '' cord-302514-rstvf3mc 170 4 interacts interact VBZ cord-302514-rstvf3mc 170 5 with with IN cord-302514-rstvf3mc 170 6 the the DT cord-302514-rstvf3mc 170 7 nucleocapsid nucleocapsid NNP cord-302514-rstvf3mc 170 8 protein protein NN cord-302514-rstvf3mc 170 9 of of IN cord-302514-rstvf3mc 170 10 transmissible transmissible JJ cord-302514-rstvf3mc 170 11 gastroenteritis gastroenteritis NN cord-302514-rstvf3mc 170 12 coronavirus coronavirus NN cord-302514-rstvf3mc 170 13 ( ( -LRB- cord-302514-rstvf3mc 170 14 TGEV TGEV NNP cord-302514-rstvf3mc 170 15 ) ) -RRB- cord-302514-rstvf3mc 170 16 and and CC cord-302514-rstvf3mc 170 17 favors favor VBZ cord-302514-rstvf3mc 170 18 TGEV TGEV NNP cord-302514-rstvf3mc 170 19 replication replication NN cord-302514-rstvf3mc 170 20 ( ( -LRB- cord-302514-rstvf3mc 170 21 103 103 CD cord-302514-rstvf3mc 170 22 ) ) -RRB- cord-302514-rstvf3mc 170 23 . . . cord-302514-rstvf3mc 171 1 Since since IN cord-302514-rstvf3mc 171 2 eEF1A eef1a NN cord-302514-rstvf3mc 171 3 is be VBZ cord-302514-rstvf3mc 171 4 found find VBN cord-302514-rstvf3mc 171 5 in in IN cord-302514-rstvf3mc 171 6 highly highly RB cord-302514-rstvf3mc 171 7 purified purify VBN cord-302514-rstvf3mc 171 8 virions virion NNS cord-302514-rstvf3mc 171 9 of of IN cord-302514-rstvf3mc 171 10 numerous numerous JJ cord-302514-rstvf3mc 171 11 RNA RNA NNP cord-302514-rstvf3mc 171 12 and and CC cord-302514-rstvf3mc 171 13 DNA dna NN cord-302514-rstvf3mc 171 14 viruses virus NNS cord-302514-rstvf3mc 171 15 including include VBG cord-302514-rstvf3mc 171 16 vesicular vesicular JJ cord-302514-rstvf3mc 171 17 stomatitis stomatitis NN cord-302514-rstvf3mc 171 18 virus virus NN cord-302514-rstvf3mc 171 19 ( ( -LRB- cord-302514-rstvf3mc 171 20 104 104 CD cord-302514-rstvf3mc 171 21 ) ) -RRB- cord-302514-rstvf3mc 171 22 , , , cord-302514-rstvf3mc 171 23 vaccinia vaccinia NN cord-302514-rstvf3mc 171 24 virus virus NN cord-302514-rstvf3mc 171 25 ( ( -LRB- cord-302514-rstvf3mc 171 26 105 105 CD cord-302514-rstvf3mc 171 27 , , , cord-302514-rstvf3mc 171 28 106 106 CD cord-302514-rstvf3mc 171 29 ) ) -RRB- cord-302514-rstvf3mc 171 30 , , , cord-302514-rstvf3mc 171 31 cytomegalovirus cytomegalovirus NNP cord-302514-rstvf3mc 171 32 ( ( -LRB- cord-302514-rstvf3mc 171 33 107 107 CD cord-302514-rstvf3mc 171 34 , , , cord-302514-rstvf3mc 171 35 108 108 CD cord-302514-rstvf3mc 171 36 ) ) -RRB- cord-302514-rstvf3mc 171 37 , , , cord-302514-rstvf3mc 171 38 severe severe JJ cord-302514-rstvf3mc 171 39 acute acute JJ cord-302514-rstvf3mc 171 40 respiratory respiratory JJ cord-302514-rstvf3mc 171 41 syndrome syndrome NN cord-302514-rstvf3mc 171 42 coronavirus coronavirus NN cord-302514-rstvf3mc 171 43 ( ( -LRB- cord-302514-rstvf3mc 171 44 SARS SARS NNP cord-302514-rstvf3mc 171 45 - - HYPH cord-302514-rstvf3mc 171 46 CoV CoV NNP cord-302514-rstvf3mc 171 47 ) ) -RRB- cord-302514-rstvf3mc 171 48 ( ( -LRB- cord-302514-rstvf3mc 171 49 109 109 CD cord-302514-rstvf3mc 171 50 ) ) -RRB- cord-302514-rstvf3mc 171 51 , , , cord-302514-rstvf3mc 171 52 and and CC cord-302514-rstvf3mc 171 53 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 171 54 ( ( -LRB- cord-302514-rstvf3mc 171 55 88 88 CD cord-302514-rstvf3mc 171 56 , , , cord-302514-rstvf3mc 171 57 112 112 CD cord-302514-rstvf3mc 171 58 ) ) -RRB- cord-302514-rstvf3mc 171 59 , , , cord-302514-rstvf3mc 171 60 its -PRON- PRP$ cord-302514-rstvf3mc 171 61 role role NN cord-302514-rstvf3mc 171 62 in in IN cord-302514-rstvf3mc 171 63 viral viral JJ cord-302514-rstvf3mc 171 64 pathogenesis pathogenesis NN cord-302514-rstvf3mc 171 65 needs need VBZ cord-302514-rstvf3mc 171 66 to to TO cord-302514-rstvf3mc 171 67 be be VB cord-302514-rstvf3mc 171 68 further further RB cord-302514-rstvf3mc 171 69 investigated investigate VBN cord-302514-rstvf3mc 171 70 . . . cord-302514-rstvf3mc 172 1 Recent recent JJ cord-302514-rstvf3mc 172 2 findings finding NNS cord-302514-rstvf3mc 172 3 in in IN cord-302514-rstvf3mc 172 4 the the DT cord-302514-rstvf3mc 172 5 field field NN cord-302514-rstvf3mc 172 6 of of IN cord-302514-rstvf3mc 172 7 cellular cellular JJ cord-302514-rstvf3mc 172 8 and and CC cord-302514-rstvf3mc 172 9 molecular molecular JJ cord-302514-rstvf3mc 172 10 biology biology NN cord-302514-rstvf3mc 172 11 reveal reveal VBP cord-302514-rstvf3mc 172 12 that that IN cord-302514-rstvf3mc 172 13 the the DT cord-302514-rstvf3mc 172 14 eEF1A eef1a NN cord-302514-rstvf3mc 172 15 proteins protein NNS cord-302514-rstvf3mc 172 16 are be VBP cord-302514-rstvf3mc 172 17 not not RB cord-302514-rstvf3mc 172 18 only only RB cord-302514-rstvf3mc 172 19 involved involve VBN cord-302514-rstvf3mc 172 20 in in IN cord-302514-rstvf3mc 172 21 the the DT cord-302514-rstvf3mc 172 22 translational translational JJ cord-302514-rstvf3mc 172 23 process process NN cord-302514-rstvf3mc 172 24 but but CC cord-302514-rstvf3mc 172 25 display display NN cord-302514-rstvf3mc 172 26 also also RB cord-302514-rstvf3mc 172 27 non non JJ cord-302514-rstvf3mc 172 28 - - JJ cord-302514-rstvf3mc 172 29 canonical canonical JJ cord-302514-rstvf3mc 172 30 functions function NNS cord-302514-rstvf3mc 172 31 . . . cord-302514-rstvf3mc 173 1 The the DT cord-302514-rstvf3mc 173 2 specific specific JJ cord-302514-rstvf3mc 173 3 up up JJ cord-302514-rstvf3mc 173 4 - - HYPH cord-302514-rstvf3mc 173 5 regulation regulation NN cord-302514-rstvf3mc 173 6 of of IN cord-302514-rstvf3mc 173 7 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 173 8 in in IN cord-302514-rstvf3mc 173 9 numerous numerous JJ cord-302514-rstvf3mc 173 10 tumors tumor NNS cord-302514-rstvf3mc 173 11 and and CC cord-302514-rstvf3mc 173 12 its -PRON- PRP$ cord-302514-rstvf3mc 173 13 transforming transform VBG cord-302514-rstvf3mc 173 14 properties property NNS cord-302514-rstvf3mc 173 15 indicate indicate VBP cord-302514-rstvf3mc 173 16 that that IN cord-302514-rstvf3mc 173 17 it -PRON- PRP cord-302514-rstvf3mc 173 18 could could MD cord-302514-rstvf3mc 173 19 play play VB cord-302514-rstvf3mc 173 20 a a DT cord-302514-rstvf3mc 173 21 significant significant JJ cord-302514-rstvf3mc 173 22 role role NN cord-302514-rstvf3mc 173 23 in in IN cord-302514-rstvf3mc 173 24 tumorigenesis tumorigenesis NN cord-302514-rstvf3mc 173 25 . . . cord-302514-rstvf3mc 174 1 Furthermore furthermore RB cord-302514-rstvf3mc 174 2 , , , cord-302514-rstvf3mc 174 3 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 174 4 activates activate VBZ cord-302514-rstvf3mc 174 5 the the DT cord-302514-rstvf3mc 174 6 phospholipid phospholipid NN cord-302514-rstvf3mc 174 7 and and CC cord-302514-rstvf3mc 174 8 Akt Akt NNP cord-302514-rstvf3mc 174 9 signaling signal VBG cord-302514-rstvf3mc 174 10 pathways pathway NNS cord-302514-rstvf3mc 174 11 favoring favor VBG cord-302514-rstvf3mc 174 12 cell cell NN cord-302514-rstvf3mc 174 13 survival survival NN cord-302514-rstvf3mc 174 14 . . . cord-302514-rstvf3mc 175 1 Additionally additionally RB cord-302514-rstvf3mc 175 2 , , , cord-302514-rstvf3mc 175 3 eEF1A eef1a NN cord-302514-rstvf3mc 175 4 proteins protein NNS cord-302514-rstvf3mc 175 5 block block VBP cord-302514-rstvf3mc 175 6 apoptosis apoptosis NN cord-302514-rstvf3mc 175 7 and and CC cord-302514-rstvf3mc 175 8 favors favor VBZ cord-302514-rstvf3mc 175 9 viral viral JJ cord-302514-rstvf3mc 175 10 replication replication NN cord-302514-rstvf3mc 175 11 . . . cord-302514-rstvf3mc 176 1 All all RB cord-302514-rstvf3mc 176 2 together together RB cord-302514-rstvf3mc 176 3 , , , cord-302514-rstvf3mc 176 4 the the DT cord-302514-rstvf3mc 176 5 non non JJ cord-302514-rstvf3mc 176 6 - - JJ cord-302514-rstvf3mc 176 7 canonical canonical JJ cord-302514-rstvf3mc 176 8 functions function NNS cord-302514-rstvf3mc 176 9 of of IN cord-302514-rstvf3mc 176 10 eEF1A eef1a CD cord-302514-rstvf3mc 176 11 proteins protein NNS cord-302514-rstvf3mc 176 12 are be VBP cord-302514-rstvf3mc 176 13 involved involve VBN cord-302514-rstvf3mc 176 14 at at IN cord-302514-rstvf3mc 176 15 the the DT cord-302514-rstvf3mc 176 16 crossroads crossroads NNP cord-302514-rstvf3mc 176 17 of of IN cord-302514-rstvf3mc 176 18 oncogenesis oncogenesis NNP cord-302514-rstvf3mc 176 19 , , , cord-302514-rstvf3mc 176 20 blockade blockade NN cord-302514-rstvf3mc 176 21 of of IN cord-302514-rstvf3mc 176 22 apoptosis apoptosis NN cord-302514-rstvf3mc 176 23 , , , cord-302514-rstvf3mc 176 24 and and CC cord-302514-rstvf3mc 176 25 viral viral JJ cord-302514-rstvf3mc 176 26 pathogenesis pathogenesis NN cord-302514-rstvf3mc 176 27 . . . cord-302514-rstvf3mc 177 1 Therefore therefore RB cord-302514-rstvf3mc 177 2 , , , cord-302514-rstvf3mc 177 3 the the DT cord-302514-rstvf3mc 177 4 eEF1A eef1a NN cord-302514-rstvf3mc 177 5 proteins protein NNS cord-302514-rstvf3mc 177 6 might may MD cord-302514-rstvf3mc 177 7 play play VB cord-302514-rstvf3mc 177 8 an an DT cord-302514-rstvf3mc 177 9 important important JJ cord-302514-rstvf3mc 177 10 role role NN cord-302514-rstvf3mc 177 11 in in IN cord-302514-rstvf3mc 177 12 the the DT cord-302514-rstvf3mc 177 13 pathophysiology pathophysiology NN cord-302514-rstvf3mc 177 14 of of IN cord-302514-rstvf3mc 177 15 tumors tumor NNS cord-302514-rstvf3mc 177 16 and and CC cord-302514-rstvf3mc 177 17 apoptosis apoptosis NN cord-302514-rstvf3mc 177 18 , , , cord-302514-rstvf3mc 177 19 especially especially RB cord-302514-rstvf3mc 177 20 in in IN cord-302514-rstvf3mc 177 21 response response NN cord-302514-rstvf3mc 177 22 to to TO cord-302514-rstvf3mc 177 23 stress stress NN cord-302514-rstvf3mc 177 24 and and CC cord-302514-rstvf3mc 177 25 viral viral JJ cord-302514-rstvf3mc 177 26 infections infection NNS cord-302514-rstvf3mc 177 27 . . . cord-302514-rstvf3mc 178 1 Future future JJ cord-302514-rstvf3mc 178 2 studies study NNS cord-302514-rstvf3mc 178 3 need need VBP cord-302514-rstvf3mc 178 4 to to TO cord-302514-rstvf3mc 178 5 be be VB cord-302514-rstvf3mc 178 6 done do VBN cord-302514-rstvf3mc 178 7 to to TO cord-302514-rstvf3mc 178 8 further further RB cord-302514-rstvf3mc 178 9 highlight highlight VB cord-302514-rstvf3mc 178 10 the the DT cord-302514-rstvf3mc 178 11 role role NN cord-302514-rstvf3mc 178 12 of of IN cord-302514-rstvf3mc 178 13 eEF1A eef1a CD cord-302514-rstvf3mc 178 14 proteins protein NNS cord-302514-rstvf3mc 178 15 in in IN cord-302514-rstvf3mc 178 16 human human JJ cord-302514-rstvf3mc 178 17 diseases disease NNS cord-302514-rstvf3mc 178 18 . . . cord-302514-rstvf3mc 179 1 WA WA NNP cord-302514-rstvf3mc 179 2 and and CC cord-302514-rstvf3mc 179 3 AK AK NNP cord-302514-rstvf3mc 179 4 were be VBD cord-302514-rstvf3mc 179 5 responsible responsible JJ cord-302514-rstvf3mc 179 6 for for IN cord-302514-rstvf3mc 179 7 drafting draft VBG cord-302514-rstvf3mc 179 8 and and CC cord-302514-rstvf3mc 179 9 revising revise VBG cord-302514-rstvf3mc 179 10 the the DT cord-302514-rstvf3mc 179 11 manuscript manuscript NN cord-302514-rstvf3mc 179 12 . . . cord-302514-rstvf3mc 180 1 GH GH NNP cord-302514-rstvf3mc 180 2 was be VBD cord-302514-rstvf3mc 180 3 involved involve VBN cord-302514-rstvf3mc 180 4 in in IN cord-302514-rstvf3mc 180 5 critical critical JJ cord-302514-rstvf3mc 180 6 reading reading NN cord-302514-rstvf3mc 180 7 of of IN cord-302514-rstvf3mc 180 8 the the DT cord-302514-rstvf3mc 180 9 manuscript manuscript NN cord-302514-rstvf3mc 180 10 . . . cord-302514-rstvf3mc 181 1 Not not RB cord-302514-rstvf3mc 181 2 just just RB cord-302514-rstvf3mc 181 3 for for IN cord-302514-rstvf3mc 181 4 housekeeping housekeeping NN cord-302514-rstvf3mc 181 5 : : : cord-302514-rstvf3mc 181 6 protein protein NN cord-302514-rstvf3mc 181 7 initiation initiation NN cord-302514-rstvf3mc 181 8 and and CC cord-302514-rstvf3mc 181 9 elongation elongation NN cord-302514-rstvf3mc 181 10 factors factor NNS cord-302514-rstvf3mc 181 11 in in IN cord-302514-rstvf3mc 181 12 cell cell NN cord-302514-rstvf3mc 181 13 growth growth NN cord-302514-rstvf3mc 181 14 and and CC cord-302514-rstvf3mc 181 15 tumorigenesis tumorigenesis NN cord-302514-rstvf3mc 181 16 Central central JJ cord-302514-rstvf3mc 181 17 dogma dogma NN cord-302514-rstvf3mc 181 18 at at IN cord-302514-rstvf3mc 181 19 the the DT cord-302514-rstvf3mc 181 20 single single JJ cord-302514-rstvf3mc 181 21 - - HYPH cord-302514-rstvf3mc 181 22 molecule molecule NN cord-302514-rstvf3mc 181 23 level level NN cord-302514-rstvf3mc 181 24 in in IN cord-302514-rstvf3mc 181 25 living living NN cord-302514-rstvf3mc 181 26 cells cell NNS cord-302514-rstvf3mc 182 1 Protein protein NN cord-302514-rstvf3mc 182 2 - - HYPH cord-302514-rstvf3mc 182 3 protein protein NN cord-302514-rstvf3mc 182 4 interactions interaction NNS cord-302514-rstvf3mc 182 5 and and CC cord-302514-rstvf3mc 182 6 cancer cancer NN cord-302514-rstvf3mc 182 7 : : : cord-302514-rstvf3mc 182 8 targeting target VBG cord-302514-rstvf3mc 182 9 the the DT cord-302514-rstvf3mc 182 10 central central JJ cord-302514-rstvf3mc 182 11 dogma dogma NN cord-302514-rstvf3mc 182 12 Modulation modulation NN cord-302514-rstvf3mc 182 13 of of IN cord-302514-rstvf3mc 182 14 molecular molecular JJ cord-302514-rstvf3mc 182 15 mechanisms mechanism NNS cord-302514-rstvf3mc 182 16 involved involve VBN cord-302514-rstvf3mc 182 17 in in IN cord-302514-rstvf3mc 182 18 protein protein NN cord-302514-rstvf3mc 182 19 synthesis synthesis NN cord-302514-rstvf3mc 182 20 machinery machinery NN cord-302514-rstvf3mc 182 21 as as IN cord-302514-rstvf3mc 182 22 a a DT cord-302514-rstvf3mc 182 23 new new JJ cord-302514-rstvf3mc 182 24 tool tool NN cord-302514-rstvf3mc 182 25 for for IN cord-302514-rstvf3mc 182 26 the the DT cord-302514-rstvf3mc 182 27 control control NN cord-302514-rstvf3mc 182 28 of of IN cord-302514-rstvf3mc 182 29 cell cell NN cord-302514-rstvf3mc 182 30 proliferation proliferation NN cord-302514-rstvf3mc 182 31 Targets target NNS cord-302514-rstvf3mc 182 32 and and CC cord-302514-rstvf3mc 182 33 mechanisms mechanism NNS cord-302514-rstvf3mc 182 34 for for IN cord-302514-rstvf3mc 182 35 the the DT cord-302514-rstvf3mc 182 36 regulation regulation NN cord-302514-rstvf3mc 182 37 of of IN cord-302514-rstvf3mc 182 38 translation translation NN cord-302514-rstvf3mc 182 39 in in IN cord-302514-rstvf3mc 182 40 malignant malignant JJ cord-302514-rstvf3mc 182 41 transformation transformation NN cord-302514-rstvf3mc 182 42 Regulation regulation NN cord-302514-rstvf3mc 182 43 of of IN cord-302514-rstvf3mc 182 44 peptide peptide NN cord-302514-rstvf3mc 182 45 - - HYPH cord-302514-rstvf3mc 182 46 chain chain NN cord-302514-rstvf3mc 182 47 elongation elongation NN cord-302514-rstvf3mc 182 48 in in IN cord-302514-rstvf3mc 182 49 mammalian mammalian JJ cord-302514-rstvf3mc 182 50 cells cell NNS cord-302514-rstvf3mc 182 51 Structural structural JJ cord-302514-rstvf3mc 182 52 models model NNS cord-302514-rstvf3mc 182 53 of of IN cord-302514-rstvf3mc 182 54 human human JJ cord-302514-rstvf3mc 182 55 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 182 56 and and CC cord-302514-rstvf3mc 182 57 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 182 58 reveal reveal VB cord-302514-rstvf3mc 182 59 two two CD cord-302514-rstvf3mc 182 60 distinct distinct JJ cord-302514-rstvf3mc 182 61 surface surface NN cord-302514-rstvf3mc 182 62 clusters cluster NNS cord-302514-rstvf3mc 182 63 of of IN cord-302514-rstvf3mc 182 64 sequence sequence NN cord-302514-rstvf3mc 182 65 variation variation NN cord-302514-rstvf3mc 182 66 and and CC cord-302514-rstvf3mc 182 67 potential potential JJ cord-302514-rstvf3mc 182 68 differences difference NNS cord-302514-rstvf3mc 182 69 in in IN cord-302514-rstvf3mc 182 70 phosphorylation phosphorylation NN cord-302514-rstvf3mc 182 71 Molecular molecular JJ cord-302514-rstvf3mc 182 72 docking docking NN cord-302514-rstvf3mc 182 73 uncovers uncover VBZ cord-302514-rstvf3mc 182 74 TSPY TSPY NNP cord-302514-rstvf3mc 182 75 binds bind VBZ cord-302514-rstvf3mc 182 76 more more RBR cord-302514-rstvf3mc 182 77 efficiently efficiently RB cord-302514-rstvf3mc 182 78 with with IN cord-302514-rstvf3mc 182 79 eEF1A2 eef1a2 XX cord-302514-rstvf3mc 182 80 compared compare VBN cord-302514-rstvf3mc 182 81 to to IN cord-302514-rstvf3mc 182 82 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 182 83 Purification purification NN cord-302514-rstvf3mc 182 84 , , , cord-302514-rstvf3mc 182 85 crystallization crystallization NN cord-302514-rstvf3mc 182 86 and and CC cord-302514-rstvf3mc 182 87 preliminary preliminary JJ cord-302514-rstvf3mc 182 88 X x NN cord-302514-rstvf3mc 182 89 - - NN cord-302514-rstvf3mc 182 90 ray ray NN cord-302514-rstvf3mc 182 91 crystallographic crystallographic JJ cord-302514-rstvf3mc 182 92 analysis analysis NN cord-302514-rstvf3mc 182 93 of of IN cord-302514-rstvf3mc 182 94 mammalian mammalian JJ cord-302514-rstvf3mc 182 95 translation translation NN cord-302514-rstvf3mc 182 96 elongation elongation NN cord-302514-rstvf3mc 182 97 factor factor NN cord-302514-rstvf3mc 182 98 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 182 99 SWISS swiss JJ cord-302514-rstvf3mc 182 100 - - HYPH cord-302514-rstvf3mc 182 101 MODEL model NN cord-302514-rstvf3mc 182 102 : : : cord-302514-rstvf3mc 182 103 an an DT cord-302514-rstvf3mc 182 104 automated automate VBN cord-302514-rstvf3mc 182 105 protein protein NN cord-302514-rstvf3mc 182 106 homology homology NN cord-302514-rstvf3mc 182 107 - - HYPH cord-302514-rstvf3mc 182 108 modeling model VBG cord-302514-rstvf3mc 182 109 server server NN cord-302514-rstvf3mc 182 110 Tissue tissue NN cord-302514-rstvf3mc 182 111 - - HYPH cord-302514-rstvf3mc 182 112 dependent dependent JJ cord-302514-rstvf3mc 182 113 variation variation NN cord-302514-rstvf3mc 182 114 in in IN cord-302514-rstvf3mc 182 115 the the DT cord-302514-rstvf3mc 182 116 expression expression NN cord-302514-rstvf3mc 182 117 of of IN cord-302514-rstvf3mc 182 118 elongation elongation NN cord-302514-rstvf3mc 182 119 factor-1 factor-1 NNP cord-302514-rstvf3mc 182 120 alpha alpha NN cord-302514-rstvf3mc 182 121 isoforms isoform NNS cord-302514-rstvf3mc 182 122 : : : cord-302514-rstvf3mc 182 123 isolation isolation NN cord-302514-rstvf3mc 182 124 and and CC cord-302514-rstvf3mc 182 125 characterisation characterisation NN cord-302514-rstvf3mc 182 126 of of IN cord-302514-rstvf3mc 182 127 a a DT cord-302514-rstvf3mc 182 128 cDNA cdna NN cord-302514-rstvf3mc 182 129 encoding encode VBG cord-302514-rstvf3mc 182 130 a a DT cord-302514-rstvf3mc 182 131 novel novel JJ cord-302514-rstvf3mc 182 132 variant variant NN cord-302514-rstvf3mc 182 133 of of IN cord-302514-rstvf3mc 182 134 human human JJ cord-302514-rstvf3mc 182 135 elongation elongation NN cord-302514-rstvf3mc 182 136 - - HYPH cord-302514-rstvf3mc 182 137 factor factor NN cord-302514-rstvf3mc 182 138 1 1 CD cord-302514-rstvf3mc 182 139 alpha alpha NN cord-302514-rstvf3mc 183 1 The the DT cord-302514-rstvf3mc 183 2 many many JJ cord-302514-rstvf3mc 183 3 roles role NNS cord-302514-rstvf3mc 183 4 of of IN cord-302514-rstvf3mc 183 5 the the DT cord-302514-rstvf3mc 183 6 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 183 7 elongation elongation NN cord-302514-rstvf3mc 183 8 factor factor NN cord-302514-rstvf3mc 183 9 1 1 CD cord-302514-rstvf3mc 183 10 complex complex NN cord-302514-rstvf3mc 184 1 In in IN cord-302514-rstvf3mc 184 2 vivo vivo NN cord-302514-rstvf3mc 184 3 characterization characterization NN cord-302514-rstvf3mc 184 4 of of IN cord-302514-rstvf3mc 184 5 the the DT cord-302514-rstvf3mc 184 6 role role NN cord-302514-rstvf3mc 184 7 of of IN cord-302514-rstvf3mc 184 8 tissue tissue NN cord-302514-rstvf3mc 184 9 - - HYPH cord-302514-rstvf3mc 184 10 specific specific JJ cord-302514-rstvf3mc 184 11 translation translation NN cord-302514-rstvf3mc 184 12 elongation elongation NN cord-302514-rstvf3mc 184 13 factor factor NN cord-302514-rstvf3mc 184 14 1A2 1a2 CD cord-302514-rstvf3mc 184 15 in in IN cord-302514-rstvf3mc 184 16 protein protein NN cord-302514-rstvf3mc 184 17 synthesis synthesis NN cord-302514-rstvf3mc 184 18 reveals reveal VBZ cord-302514-rstvf3mc 184 19 insights insight NNS cord-302514-rstvf3mc 184 20 into into IN cord-302514-rstvf3mc 184 21 muscle muscle NN cord-302514-rstvf3mc 184 22 atrophy atrophy NN cord-302514-rstvf3mc 185 1 The the DT cord-302514-rstvf3mc 185 2 elongation elongation NN cord-302514-rstvf3mc 185 3 factor factor NN cord-302514-rstvf3mc 185 4 1 1 CD cord-302514-rstvf3mc 185 5 A-2 A-2 NNP cord-302514-rstvf3mc 185 6 isoform isoform NN cord-302514-rstvf3mc 185 7 from from IN cord-302514-rstvf3mc 185 8 rabbit rabbit NN cord-302514-rstvf3mc 185 9 : : : cord-302514-rstvf3mc 185 10 cloning cloning NN cord-302514-rstvf3mc 185 11 of of IN cord-302514-rstvf3mc 185 12 the the DT cord-302514-rstvf3mc 185 13 cDNA cdna NN cord-302514-rstvf3mc 185 14 and and CC cord-302514-rstvf3mc 185 15 characterization characterization NN cord-302514-rstvf3mc 185 16 of of IN cord-302514-rstvf3mc 185 17 the the DT cord-302514-rstvf3mc 185 18 protein protein NN cord-302514-rstvf3mc 185 19 Assignment Assignment NNP cord-302514-rstvf3mc 185 20 of of IN cord-302514-rstvf3mc 185 21 human human JJ cord-302514-rstvf3mc 185 22 elongation elongation NN cord-302514-rstvf3mc 185 23 factor factor NN cord-302514-rstvf3mc 185 24 1alpha 1alpha CD cord-302514-rstvf3mc 185 25 genes gene NNS cord-302514-rstvf3mc 185 26 : : : cord-302514-rstvf3mc 185 27 eEF1A eef1a CD cord-302514-rstvf3mc 185 28 maps map NNS cord-302514-rstvf3mc 185 29 to to TO cord-302514-rstvf3mc 185 30 chromosome chromosome VB cord-302514-rstvf3mc 185 31 6q14 6q14 CD cord-302514-rstvf3mc 185 32 and and CC cord-302514-rstvf3mc 185 33 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 185 34 to to IN cord-302514-rstvf3mc 185 35 20q13 20q13 CD cord-302514-rstvf3mc 185 36 Highly highly RB cord-302514-rstvf3mc 185 37 homologous homologous JJ cord-302514-rstvf3mc 185 38 eEF1A1 eef1a1 DT cord-302514-rstvf3mc 185 39 and and CC cord-302514-rstvf3mc 185 40 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 185 41 exhibit exhibit VB cord-302514-rstvf3mc 185 42 differential differential JJ cord-302514-rstvf3mc 185 43 post post JJ cord-302514-rstvf3mc 185 44 - - JJ cord-302514-rstvf3mc 185 45 translational translational JJ cord-302514-rstvf3mc 185 46 modification modification NN cord-302514-rstvf3mc 185 47 with with IN cord-302514-rstvf3mc 185 48 significant significant JJ cord-302514-rstvf3mc 185 49 enrichment enrichment NN cord-302514-rstvf3mc 185 50 around around IN cord-302514-rstvf3mc 185 51 localised localised JJ cord-302514-rstvf3mc 185 52 sites site NNS cord-302514-rstvf3mc 185 53 of of IN cord-302514-rstvf3mc 185 54 sequence sequence NN cord-302514-rstvf3mc 185 55 variation variation NN cord-302514-rstvf3mc 185 56 Raf Raf NNP cord-302514-rstvf3mc 185 57 kinases kinase NNS cord-302514-rstvf3mc 185 58 mediate mediate VBP cord-302514-rstvf3mc 185 59 the the DT cord-302514-rstvf3mc 185 60 phosphorylation phosphorylation NN cord-302514-rstvf3mc 185 61 of of IN cord-302514-rstvf3mc 185 62 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 185 63 translation translation NN cord-302514-rstvf3mc 185 64 elongation elongation NN cord-302514-rstvf3mc 185 65 factor factor NN cord-302514-rstvf3mc 185 66 1A 1a NN cord-302514-rstvf3mc 185 67 and and CC cord-302514-rstvf3mc 185 68 regulate regulate VB cord-302514-rstvf3mc 185 69 its -PRON- PRP$ cord-302514-rstvf3mc 185 70 stability stability NN cord-302514-rstvf3mc 185 71 in in IN cord-302514-rstvf3mc 185 72 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 185 73 cells cell NNS cord-302514-rstvf3mc 185 74 eEF1A eEF1A VBG cord-302514-rstvf3mc 185 75 is be VBZ cord-302514-rstvf3mc 185 76 a a DT cord-302514-rstvf3mc 185 77 novel novel JJ cord-302514-rstvf3mc 185 78 component component NN cord-302514-rstvf3mc 185 79 of of IN cord-302514-rstvf3mc 185 80 the the DT cord-302514-rstvf3mc 185 81 mammalian mammalian JJ cord-302514-rstvf3mc 185 82 nuclear nuclear JJ cord-302514-rstvf3mc 185 83 protein protein NN cord-302514-rstvf3mc 185 84 export export NN cord-302514-rstvf3mc 185 85 machinery machinery NN cord-302514-rstvf3mc 186 1 The the DT cord-302514-rstvf3mc 186 2 human human JJ cord-302514-rstvf3mc 186 3 elongation elongation NN cord-302514-rstvf3mc 186 4 factor factor NN cord-302514-rstvf3mc 186 5 1 1 CD cord-302514-rstvf3mc 186 6 A-2 a-2 NN cord-302514-rstvf3mc 186 7 gene gene NN cord-302514-rstvf3mc 186 8 ( ( -LRB- cord-302514-rstvf3mc 186 9 EEF1A2 EEF1A2 NNP cord-302514-rstvf3mc 186 10 ) ) -RRB- cord-302514-rstvf3mc 186 11 : : : cord-302514-rstvf3mc 186 12 complete complete VB cord-302514-rstvf3mc 186 13 sequence sequence NN cord-302514-rstvf3mc 186 14 and and CC cord-302514-rstvf3mc 186 15 characterization characterization NN cord-302514-rstvf3mc 186 16 of of IN cord-302514-rstvf3mc 186 17 gene gene NN cord-302514-rstvf3mc 186 18 structure structure NN cord-302514-rstvf3mc 186 19 and and CC cord-302514-rstvf3mc 186 20 promoter promoter NN cord-302514-rstvf3mc 186 21 activity activity NN cord-302514-rstvf3mc 187 1 The the DT cord-302514-rstvf3mc 187 2 translation translation NN cord-302514-rstvf3mc 187 3 elongation elongation NN cord-302514-rstvf3mc 187 4 factor factor NN cord-302514-rstvf3mc 187 5 1A 1a NN cord-302514-rstvf3mc 187 6 in in IN cord-302514-rstvf3mc 187 7 tumorigenesis tumorigenesis NN cord-302514-rstvf3mc 187 8 , , , cord-302514-rstvf3mc 187 9 signal signal NN cord-302514-rstvf3mc 187 10 transduction transduction NN cord-302514-rstvf3mc 187 11 and and CC cord-302514-rstvf3mc 187 12 apoptosis apoptosis NN cord-302514-rstvf3mc 187 13 : : : cord-302514-rstvf3mc 187 14 review review VB cord-302514-rstvf3mc 187 15 article article NN cord-302514-rstvf3mc 187 16 Degradation degradation NN cord-302514-rstvf3mc 187 17 of of IN cord-302514-rstvf3mc 187 18 newly newly RB cord-302514-rstvf3mc 187 19 synthesized synthesize VBN cord-302514-rstvf3mc 187 20 polypeptides polypeptide NNS cord-302514-rstvf3mc 187 21 by by IN cord-302514-rstvf3mc 187 22 ribosome ribosome NN cord-302514-rstvf3mc 187 23 - - HYPH cord-302514-rstvf3mc 187 24 associated associate VBN cord-302514-rstvf3mc 187 25 RACK1 rack1 NN cord-302514-rstvf3mc 187 26 / / SYM cord-302514-rstvf3mc 187 27 c c NN cord-302514-rstvf3mc 187 28 - - : cord-302514-rstvf3mc 187 29 Jun Jun NNP cord-302514-rstvf3mc 187 30 N N NNP cord-302514-rstvf3mc 187 31 - - HYPH cord-302514-rstvf3mc 187 32 terminal terminal NN cord-302514-rstvf3mc 187 33 kinase kinase NN cord-302514-rstvf3mc 187 34 / / SYM cord-302514-rstvf3mc 187 35 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 187 36 elongation elongation NN cord-302514-rstvf3mc 187 37 factor factor NN cord-302514-rstvf3mc 188 1 1A2 1a2 CD cord-302514-rstvf3mc 188 2 complex complex JJ cord-302514-rstvf3mc 188 3 Exome Exome NNP cord-302514-rstvf3mc 188 4 sequencing sequencing NN cord-302514-rstvf3mc 188 5 reveals reveal VBZ cord-302514-rstvf3mc 188 6 new new JJ cord-302514-rstvf3mc 188 7 causal causal JJ cord-302514-rstvf3mc 188 8 mutations mutation NNS cord-302514-rstvf3mc 188 9 in in IN cord-302514-rstvf3mc 188 10 children child NNS cord-302514-rstvf3mc 188 11 with with IN cord-302514-rstvf3mc 188 12 epileptic epileptic JJ cord-302514-rstvf3mc 188 13 encephalopathies encephalopathy NNS cord-302514-rstvf3mc 189 1 The the DT cord-302514-rstvf3mc 189 2 utrophin utrophin JJ cord-302514-rstvf3mc 189 3 A A NNP cord-302514-rstvf3mc 189 4 5'-UTR 5'-utr CD cord-302514-rstvf3mc 189 5 drives drive NNS cord-302514-rstvf3mc 189 6 cap cap NN cord-302514-rstvf3mc 189 7 - - HYPH cord-302514-rstvf3mc 189 8 independent independent JJ cord-302514-rstvf3mc 189 9 translation translation NN cord-302514-rstvf3mc 189 10 exclusively exclusively RB cord-302514-rstvf3mc 189 11 in in IN cord-302514-rstvf3mc 189 12 skeletal skeletal JJ cord-302514-rstvf3mc 189 13 muscles muscle NNS cord-302514-rstvf3mc 189 14 of of IN cord-302514-rstvf3mc 189 15 transgenic transgenic JJ cord-302514-rstvf3mc 189 16 mice mouse NNS cord-302514-rstvf3mc 189 17 and and CC cord-302514-rstvf3mc 189 18 interacts interact VBZ cord-302514-rstvf3mc 189 19 with with IN cord-302514-rstvf3mc 189 20 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 189 21 Shaping shape VBG cord-302514-rstvf3mc 189 22 the the DT cord-302514-rstvf3mc 189 23 future future NN cord-302514-rstvf3mc 189 24 of of IN cord-302514-rstvf3mc 189 25 biomarker biomarker NN cord-302514-rstvf3mc 189 26 research research NN cord-302514-rstvf3mc 189 27 in in IN cord-302514-rstvf3mc 189 28 breast breast NN cord-302514-rstvf3mc 189 29 cancer cancer NN cord-302514-rstvf3mc 189 30 to to TO cord-302514-rstvf3mc 189 31 ensure ensure VB cord-302514-rstvf3mc 189 32 clinical clinical JJ cord-302514-rstvf3mc 189 33 relevance relevance NN cord-302514-rstvf3mc 190 1 Translation translation NN cord-302514-rstvf3mc 190 2 elongation elongation NN cord-302514-rstvf3mc 190 3 factor factor NN cord-302514-rstvf3mc 191 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 191 2 is be VBZ cord-302514-rstvf3mc 191 3 a a DT cord-302514-rstvf3mc 191 4 potential potential JJ cord-302514-rstvf3mc 191 5 oncoprotein oncoprotein NN cord-302514-rstvf3mc 191 6 that that WDT cord-302514-rstvf3mc 191 7 is be VBZ cord-302514-rstvf3mc 191 8 overexpressed overexpresse VBN cord-302514-rstvf3mc 191 9 in in IN cord-302514-rstvf3mc 191 10 two two CD cord-302514-rstvf3mc 191 11 - - HYPH cord-302514-rstvf3mc 191 12 thirds third NNS cord-302514-rstvf3mc 191 13 of of IN cord-302514-rstvf3mc 191 14 breast breast NN cord-302514-rstvf3mc 191 15 tumours tumour NNS cord-302514-rstvf3mc 191 16 Novel novel JJ cord-302514-rstvf3mc 191 17 flavonoids flavonoid NNS cord-302514-rstvf3mc 191 18 with with IN cord-302514-rstvf3mc 191 19 antiproliferative antiproliferative JJ cord-302514-rstvf3mc 191 20 activities activity NNS cord-302514-rstvf3mc 191 21 against against IN cord-302514-rstvf3mc 191 22 breast breast NN cord-302514-rstvf3mc 191 23 cancer cancer NN cord-302514-rstvf3mc 191 24 cells cell NNS cord-302514-rstvf3mc 192 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 192 2 activates activate VBZ cord-302514-rstvf3mc 192 3 Akt Akt NNP cord-302514-rstvf3mc 192 4 and and CC cord-302514-rstvf3mc 192 5 stimulates stimulate VBZ cord-302514-rstvf3mc 192 6 Akt Akt NNP cord-302514-rstvf3mc 192 7 - - HYPH cord-302514-rstvf3mc 192 8 dependent dependent JJ cord-302514-rstvf3mc 192 9 actin actin NN cord-302514-rstvf3mc 192 10 remodeling remodeling NN cord-302514-rstvf3mc 192 11 , , , cord-302514-rstvf3mc 192 12 invasion invasion NN cord-302514-rstvf3mc 192 13 and and CC cord-302514-rstvf3mc 192 14 migration migration NN cord-302514-rstvf3mc 192 15 Elongation elongation NN cord-302514-rstvf3mc 192 16 factor factor NN cord-302514-rstvf3mc 192 17 1 1 CD cord-302514-rstvf3mc 192 18 alpha alpha NN cord-302514-rstvf3mc 192 19 interacts interact VBZ cord-302514-rstvf3mc 192 20 with with IN cord-302514-rstvf3mc 192 21 phospho phospho NNP cord-302514-rstvf3mc 192 22 - - HYPH cord-302514-rstvf3mc 192 23 Akt Akt NNP cord-302514-rstvf3mc 192 24 in in IN cord-302514-rstvf3mc 192 25 breast breast NN cord-302514-rstvf3mc 192 26 cancer cancer NN cord-302514-rstvf3mc 192 27 cells cell NNS cord-302514-rstvf3mc 192 28 and and CC cord-302514-rstvf3mc 192 29 regulates regulate VBZ cord-302514-rstvf3mc 192 30 their -PRON- PRP$ cord-302514-rstvf3mc 192 31 proliferation proliferation NN cord-302514-rstvf3mc 192 32 , , , cord-302514-rstvf3mc 192 33 survival survival NN cord-302514-rstvf3mc 192 34 and and CC cord-302514-rstvf3mc 192 35 motility motility NN cord-302514-rstvf3mc 192 36 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 192 37 promotes promote VBZ cord-302514-rstvf3mc 192 38 cell cell NN cord-302514-rstvf3mc 192 39 growth growth NN cord-302514-rstvf3mc 192 40 , , , cord-302514-rstvf3mc 192 41 inhibits inhibit VBZ cord-302514-rstvf3mc 192 42 apoptosis apoptosis NN cord-302514-rstvf3mc 192 43 and and CC cord-302514-rstvf3mc 192 44 activates activate VBZ cord-302514-rstvf3mc 192 45 JAK JAK NNP cord-302514-rstvf3mc 192 46 / / SYM cord-302514-rstvf3mc 192 47 STAT stat NN cord-302514-rstvf3mc 192 48 and and CC cord-302514-rstvf3mc 192 49 AKT AKT NNP cord-302514-rstvf3mc 192 50 signaling signal VBG cord-302514-rstvf3mc 192 51 in in IN cord-302514-rstvf3mc 192 52 mouse mouse NN cord-302514-rstvf3mc 192 53 plasmacytomas plasmacytomas NNP cord-302514-rstvf3mc 192 54 Phosphoinositide Phosphoinositide NNP cord-302514-rstvf3mc 192 55 kinases kinase NNS cord-302514-rstvf3mc 192 56 Phosphoinositide Phosphoinositide NNP cord-302514-rstvf3mc 192 57 signalling signal VBG cord-302514-rstvf3mc 192 58 in in IN cord-302514-rstvf3mc 192 59 cancer cancer NN cord-302514-rstvf3mc 192 60 : : : cord-302514-rstvf3mc 192 61 beyond beyond IN cord-302514-rstvf3mc 192 62 PI3 PI3 NNP cord-302514-rstvf3mc 192 63 K K NNP cord-302514-rstvf3mc 192 64 and and CC cord-302514-rstvf3mc 192 65 PTEN PTEN NNP cord-302514-rstvf3mc 192 66 Phosphatidylinositol Phosphatidylinositol NNP cord-302514-rstvf3mc 192 67 4-kinases 4-kinases CD cord-302514-rstvf3mc 192 68 : : : cord-302514-rstvf3mc 193 1 old old JJ cord-302514-rstvf3mc 193 2 enzymes enzyme NNS cord-302514-rstvf3mc 193 3 with with IN cord-302514-rstvf3mc 193 4 emerging emerge VBG cord-302514-rstvf3mc 193 5 functions function NNS cord-302514-rstvf3mc 194 1 Phosphoinositide Phosphoinositide NNP cord-302514-rstvf3mc 194 2 kinases kinase NNS cord-302514-rstvf3mc 194 3 Binding bind VBG cord-302514-rstvf3mc 194 4 of of IN cord-302514-rstvf3mc 194 5 elongation elongation NN cord-302514-rstvf3mc 194 6 factor factor NN cord-302514-rstvf3mc 194 7 eEF1A2 eef1a2 XX cord-302514-rstvf3mc 194 8 to to IN cord-302514-rstvf3mc 194 9 phosphatidylinositol phosphatidylinositol NN cord-302514-rstvf3mc 195 1 4-kinase 4-kinase CD cord-302514-rstvf3mc 196 1 beta beta NN cord-302514-rstvf3mc 196 2 stimulates stimulate VBZ cord-302514-rstvf3mc 196 3 lipid lipid NN cord-302514-rstvf3mc 196 4 kinase kinase NN cord-302514-rstvf3mc 196 5 activity activity NN cord-302514-rstvf3mc 196 6 and and CC cord-302514-rstvf3mc 196 7 phosphatidylinositol phosphatidylinositol JJ cord-302514-rstvf3mc 196 8 4-phosphate 4-phosphate CD cord-302514-rstvf3mc 196 9 generation generation NN cord-302514-rstvf3mc 197 1 The the DT cord-302514-rstvf3mc 197 2 lipid lipid NN cord-302514-rstvf3mc 197 3 kinase kinase NN cord-302514-rstvf3mc 198 1 PI4KIIIbeta PI4KIIIbeta NNP cord-302514-rstvf3mc 198 2 and and CC cord-302514-rstvf3mc 198 3 the the DT cord-302514-rstvf3mc 198 4 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 198 5 oncogene oncogene NN cord-302514-rstvf3mc 198 6 cooperate cooperate VB cord-302514-rstvf3mc 198 7 to to TO cord-302514-rstvf3mc 198 8 disrupt disrupt VB cord-302514-rstvf3mc 198 9 three three CD cord-302514-rstvf3mc 198 10 - - HYPH cord-302514-rstvf3mc 198 11 dimensional dimensional JJ cord-302514-rstvf3mc 198 12 in in IN cord-302514-rstvf3mc 198 13 vitro vitro FW cord-302514-rstvf3mc 198 14 acinar acinar NN cord-302514-rstvf3mc 198 15 morphogenesis morphogenesis NN cord-302514-rstvf3mc 198 16 Eukaryotic eukaryotic JJ cord-302514-rstvf3mc 198 17 elongation elongation NN cord-302514-rstvf3mc 198 18 factor factor NN cord-302514-rstvf3mc 198 19 1A2 1a2 CD cord-302514-rstvf3mc 198 20 cooperates cooperate VBZ cord-302514-rstvf3mc 198 21 with with IN cord-302514-rstvf3mc 198 22 phosphatidylinositol-4 phosphatidylinositol-4 NNP cord-302514-rstvf3mc 198 23 kinase kinase NN cord-302514-rstvf3mc 198 24 III iii CD cord-302514-rstvf3mc 198 25 beta beta NN cord-302514-rstvf3mc 198 26 to to TO cord-302514-rstvf3mc 198 27 stimulate stimulate VB cord-302514-rstvf3mc 198 28 production production NN cord-302514-rstvf3mc 198 29 of of IN cord-302514-rstvf3mc 198 30 filopodia filopodia NNS cord-302514-rstvf3mc 198 31 through through IN cord-302514-rstvf3mc 198 32 increased increase VBN cord-302514-rstvf3mc 198 33 phosphatidylinositol-4,5 phosphatidylinositol-4,5 JJ cord-302514-rstvf3mc 198 34 bisphosphate bisphosphate JJ cord-302514-rstvf3mc 198 35 generation generation NN cord-302514-rstvf3mc 198 36 Proto proto JJ cord-302514-rstvf3mc 198 37 - - HYPH cord-302514-rstvf3mc 198 38 oncogenic oncogenic JJ cord-302514-rstvf3mc 198 39 isoform isoform NN cord-302514-rstvf3mc 198 40 A2 a2 NN cord-302514-rstvf3mc 198 41 of of IN cord-302514-rstvf3mc 198 42 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 198 43 translation translation NN cord-302514-rstvf3mc 198 44 elongation elongation NN cord-302514-rstvf3mc 198 45 factor factor NN cord-302514-rstvf3mc 198 46 eEF1 eEF1 NNP cord-302514-rstvf3mc 198 47 is be VBZ cord-302514-rstvf3mc 198 48 a a DT cord-302514-rstvf3mc 198 49 target target NN cord-302514-rstvf3mc 198 50 of of IN cord-302514-rstvf3mc 198 51 miR-663 miR-663 NNP cord-302514-rstvf3mc 198 52 and and CC cord-302514-rstvf3mc 198 53 miR-744 miR-744 NNP cord-302514-rstvf3mc 198 54 Tumor Tumor NNP cord-302514-rstvf3mc 198 55 suppressor suppressor NN cord-302514-rstvf3mc 198 56 p16(INK4a p16(INK4a NNP cord-302514-rstvf3mc 198 57 ) ) -RRB- cord-302514-rstvf3mc 198 58 inhibits inhibit VBZ cord-302514-rstvf3mc 198 59 cancer cancer NN cord-302514-rstvf3mc 198 60 cell cell NN cord-302514-rstvf3mc 198 61 growth growth NN cord-302514-rstvf3mc 198 62 by by IN cord-302514-rstvf3mc 198 63 downregulating downregulate VBG cord-302514-rstvf3mc 198 64 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 198 65 through through IN cord-302514-rstvf3mc 198 66 a a DT cord-302514-rstvf3mc 198 67 direct direct JJ cord-302514-rstvf3mc 198 68 interaction interaction NN cord-302514-rstvf3mc 198 69 Expression expression NN cord-302514-rstvf3mc 198 70 of of IN cord-302514-rstvf3mc 198 71 protein protein NN cord-302514-rstvf3mc 198 72 elongation elongation NN cord-302514-rstvf3mc 198 73 factor factor NN cord-302514-rstvf3mc 199 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 199 2 predicts predict VBZ cord-302514-rstvf3mc 199 3 favorable favorable JJ cord-302514-rstvf3mc 199 4 outcome outcome NN cord-302514-rstvf3mc 199 5 in in IN cord-302514-rstvf3mc 199 6 breast breast NN cord-302514-rstvf3mc 199 7 cancer cancer NN cord-302514-rstvf3mc 199 8 Protein Protein NNP cord-302514-rstvf3mc 199 9 elongation elongation NN cord-302514-rstvf3mc 199 10 factor factor NN cord-302514-rstvf3mc 200 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 200 2 is be VBZ cord-302514-rstvf3mc 200 3 a a DT cord-302514-rstvf3mc 200 4 putative putative JJ cord-302514-rstvf3mc 200 5 oncogene oncogene NN cord-302514-rstvf3mc 200 6 in in IN cord-302514-rstvf3mc 200 7 ovarian ovarian JJ cord-302514-rstvf3mc 200 8 cancer cancer NN cord-302514-rstvf3mc 200 9 High high JJ cord-302514-rstvf3mc 200 10 resolution resolution NN cord-302514-rstvf3mc 200 11 analysis analysis NN cord-302514-rstvf3mc 200 12 of of IN cord-302514-rstvf3mc 200 13 genomic genomic JJ cord-302514-rstvf3mc 200 14 aberrations aberration NNS cord-302514-rstvf3mc 200 15 by by IN cord-302514-rstvf3mc 200 16 metaphase metaphase NN cord-302514-rstvf3mc 200 17 and and CC cord-302514-rstvf3mc 200 18 array array VB cord-302514-rstvf3mc 200 19 comparative comparative JJ cord-302514-rstvf3mc 200 20 genomic genomic JJ cord-302514-rstvf3mc 200 21 hybridization hybridization NN cord-302514-rstvf3mc 201 1 identifies identify VBZ cord-302514-rstvf3mc 201 2 candidate candidate NN cord-302514-rstvf3mc 201 3 tumour tumour NN cord-302514-rstvf3mc 201 4 genes gene NNS cord-302514-rstvf3mc 201 5 in in IN cord-302514-rstvf3mc 201 6 lung lung NN cord-302514-rstvf3mc 201 7 cancer cancer NN cord-302514-rstvf3mc 201 8 cell cell NN cord-302514-rstvf3mc 201 9 lines line NNS cord-302514-rstvf3mc 201 10 Identification Identification NNP cord-302514-rstvf3mc 201 11 of of IN cord-302514-rstvf3mc 201 12 putative putative JJ cord-302514-rstvf3mc 201 13 oncogenes oncogene NNS cord-302514-rstvf3mc 201 14 in in IN cord-302514-rstvf3mc 201 15 lung lung NN cord-302514-rstvf3mc 201 16 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 201 17 by by IN cord-302514-rstvf3mc 201 18 a a DT cord-302514-rstvf3mc 201 19 comprehensive comprehensive JJ cord-302514-rstvf3mc 201 20 functional functional JJ cord-302514-rstvf3mc 201 21 genomic genomic JJ cord-302514-rstvf3mc 201 22 approach approach NN cord-302514-rstvf3mc 202 1 The the DT cord-302514-rstvf3mc 202 2 expression expression NN cord-302514-rstvf3mc 202 3 levels level NNS cord-302514-rstvf3mc 202 4 of of IN cord-302514-rstvf3mc 202 5 the the DT cord-302514-rstvf3mc 202 6 translational translational JJ cord-302514-rstvf3mc 202 7 factors factor NNS cord-302514-rstvf3mc 202 8 eEF1A eef1a CD cord-302514-rstvf3mc 202 9 1/2 1/2 CD cord-302514-rstvf3mc 202 10 correlate correlate VBP cord-302514-rstvf3mc 202 11 with with IN cord-302514-rstvf3mc 202 12 cell cell NN cord-302514-rstvf3mc 202 13 growth growth NN cord-302514-rstvf3mc 202 14 but but CC cord-302514-rstvf3mc 202 15 not not RB cord-302514-rstvf3mc 202 16 apoptosis apoptosis NN cord-302514-rstvf3mc 202 17 in in IN cord-302514-rstvf3mc 202 18 hepatocellular hepatocellular JJ cord-302514-rstvf3mc 202 19 carcinoma carcinoma NN cord-302514-rstvf3mc 202 20 cell cell NN cord-302514-rstvf3mc 202 21 lines line NNS cord-302514-rstvf3mc 202 22 with with IN cord-302514-rstvf3mc 202 23 different different JJ cord-302514-rstvf3mc 202 24 differentiation differentiation NN cord-302514-rstvf3mc 202 25 grade grade NN cord-302514-rstvf3mc 202 26 Etiology etiology NN cord-302514-rstvf3mc 202 27 - - HYPH cord-302514-rstvf3mc 202 28 dependent dependent JJ cord-302514-rstvf3mc 202 29 molecular molecular JJ cord-302514-rstvf3mc 202 30 mechanisms mechanism NNS cord-302514-rstvf3mc 202 31 in in IN cord-302514-rstvf3mc 202 32 human human JJ cord-302514-rstvf3mc 202 33 hepatocarcinogenesis hepatocarcinogenesis NN cord-302514-rstvf3mc 202 34 Amplification amplification NN cord-302514-rstvf3mc 202 35 of of IN cord-302514-rstvf3mc 202 36 chromosomal chromosomal JJ cord-302514-rstvf3mc 202 37 region region NN cord-302514-rstvf3mc 202 38 20q13 20q13 CD cord-302514-rstvf3mc 202 39 in in IN cord-302514-rstvf3mc 202 40 invasive invasive JJ cord-302514-rstvf3mc 202 41 breast breast NN cord-302514-rstvf3mc 202 42 cancer cancer NN cord-302514-rstvf3mc 202 43 : : : cord-302514-rstvf3mc 203 1 prognostic prognostic JJ cord-302514-rstvf3mc 203 2 implications implication NNS cord-302514-rstvf3mc 204 1 Elongation elongation NN cord-302514-rstvf3mc 204 2 factor-1 factor-1 NNP cord-302514-rstvf3mc 204 3 alpha alpha NN cord-302514-rstvf3mc 204 4 is be VBZ cord-302514-rstvf3mc 204 5 an an DT cord-302514-rstvf3mc 204 6 overexpressed overexpressed JJ cord-302514-rstvf3mc 204 7 actin actin NN cord-302514-rstvf3mc 204 8 binding bind VBG cord-302514-rstvf3mc 204 9 protein protein NN cord-302514-rstvf3mc 204 10 in in IN cord-302514-rstvf3mc 204 11 metastatic metastatic JJ cord-302514-rstvf3mc 204 12 rat rat NN cord-302514-rstvf3mc 204 13 mammary mammary JJ cord-302514-rstvf3mc 204 14 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 204 15 Expression Expression NNP cord-302514-rstvf3mc 204 16 profile profile NN cord-302514-rstvf3mc 204 17 of of IN cord-302514-rstvf3mc 204 18 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 204 19 translation translation NN cord-302514-rstvf3mc 204 20 factors factor NNS cord-302514-rstvf3mc 204 21 in in IN cord-302514-rstvf3mc 204 22 human human JJ cord-302514-rstvf3mc 204 23 cancer cancer NN cord-302514-rstvf3mc 204 24 tissues tissue NNS cord-302514-rstvf3mc 204 25 and and CC cord-302514-rstvf3mc 204 26 cell cell NN cord-302514-rstvf3mc 204 27 lines line NNS cord-302514-rstvf3mc 205 1 Up up IN cord-302514-rstvf3mc 205 2 - - HYPH cord-302514-rstvf3mc 205 3 regulation regulation NN cord-302514-rstvf3mc 205 4 of of IN cord-302514-rstvf3mc 205 5 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 205 6 promotes promote VBZ cord-302514-rstvf3mc 205 7 proliferation proliferation NN cord-302514-rstvf3mc 205 8 and and CC cord-302514-rstvf3mc 205 9 inhibits inhibit VBZ cord-302514-rstvf3mc 205 10 apoptosis apoptosis NN cord-302514-rstvf3mc 205 11 in in IN cord-302514-rstvf3mc 205 12 prostate prostate NN cord-302514-rstvf3mc 205 13 cancer cancer NN cord-302514-rstvf3mc 205 14 iTRAQ itraq IN cord-302514-rstvf3mc 205 15 identification identification NN cord-302514-rstvf3mc 205 16 of of IN cord-302514-rstvf3mc 205 17 candidate candidate NN cord-302514-rstvf3mc 205 18 serum serum NN cord-302514-rstvf3mc 205 19 biomarkers biomarker NNS cord-302514-rstvf3mc 205 20 associated associate VBN cord-302514-rstvf3mc 205 21 with with IN cord-302514-rstvf3mc 205 22 metastatic metastatic JJ cord-302514-rstvf3mc 205 23 progression progression NN cord-302514-rstvf3mc 205 24 of of IN cord-302514-rstvf3mc 205 25 human human JJ cord-302514-rstvf3mc 205 26 prostate prostate NN cord-302514-rstvf3mc 205 27 cancer cancer NN cord-302514-rstvf3mc 205 28 Elongation Elongation NNP cord-302514-rstvf3mc 205 29 factor-1 factor-1 NNP cord-302514-rstvf3mc 205 30 alpha alpha NN cord-302514-rstvf3mc 205 31 gene gene NN cord-302514-rstvf3mc 205 32 determines determine VBZ cord-302514-rstvf3mc 205 33 susceptibility susceptibility NN cord-302514-rstvf3mc 205 34 to to IN cord-302514-rstvf3mc 205 35 transformation transformation NN cord-302514-rstvf3mc 205 36 Ovarian ovarian JJ cord-302514-rstvf3mc 205 37 cancer cancer NN cord-302514-rstvf3mc 205 38 : : : cord-302514-rstvf3mc 205 39 strategies strategy NNS cord-302514-rstvf3mc 205 40 for for IN cord-302514-rstvf3mc 205 41 overcoming overcome VBG cord-302514-rstvf3mc 205 42 resistance resistance NN cord-302514-rstvf3mc 205 43 to to IN cord-302514-rstvf3mc 205 44 chemotherapy chemotherapy NN cord-302514-rstvf3mc 205 45 Ovarian ovarian JJ cord-302514-rstvf3mc 205 46 cancer cancer NN cord-302514-rstvf3mc 205 47 metastasis metastasis NN cord-302514-rstvf3mc 205 48 : : : cord-302514-rstvf3mc 205 49 integrating integrate VBG cord-302514-rstvf3mc 205 50 insights insight NNS cord-302514-rstvf3mc 205 51 from from IN cord-302514-rstvf3mc 205 52 disparate disparate JJ cord-302514-rstvf3mc 205 53 model model NN cord-302514-rstvf3mc 205 54 organisms organism NNS cord-302514-rstvf3mc 205 55 Ovarian ovarian JJ cord-302514-rstvf3mc 205 56 cancer cancer NN cord-302514-rstvf3mc 205 57 Therapeutic therapeutic JJ cord-302514-rstvf3mc 205 58 strategies strategy NNS cord-302514-rstvf3mc 205 59 in in IN cord-302514-rstvf3mc 205 60 epithelial epithelial JJ cord-302514-rstvf3mc 205 61 ovarian ovarian JJ cord-302514-rstvf3mc 205 62 cancer cancer NN cord-302514-rstvf3mc 205 63 Expression expression NN cord-302514-rstvf3mc 205 64 of of IN cord-302514-rstvf3mc 205 65 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 205 66 is be VBZ cord-302514-rstvf3mc 205 67 associated associate VBN cord-302514-rstvf3mc 205 68 with with IN cord-302514-rstvf3mc 205 69 clear clear JJ cord-302514-rstvf3mc 205 70 cell cell NN cord-302514-rstvf3mc 205 71 histology histology NN cord-302514-rstvf3mc 205 72 in in IN cord-302514-rstvf3mc 205 73 ovarian ovarian JJ cord-302514-rstvf3mc 205 74 carcinomas carcinoma NNS cord-302514-rstvf3mc 205 75 : : : cord-302514-rstvf3mc 205 76 overexpression overexpression NN cord-302514-rstvf3mc 205 77 of of IN cord-302514-rstvf3mc 205 78 the the DT cord-302514-rstvf3mc 205 79 gene gene NN cord-302514-rstvf3mc 205 80 is be VBZ cord-302514-rstvf3mc 205 81 not not RB cord-302514-rstvf3mc 205 82 dependent dependent JJ cord-302514-rstvf3mc 205 83 on on IN cord-302514-rstvf3mc 205 84 modifications modification NNS cord-302514-rstvf3mc 205 85 at at IN cord-302514-rstvf3mc 205 86 the the DT cord-302514-rstvf3mc 205 87 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 205 88 locus locus NN cord-302514-rstvf3mc 206 1 The the DT cord-302514-rstvf3mc 206 2 prognostic prognostic JJ cord-302514-rstvf3mc 206 3 significance significance NN cord-302514-rstvf3mc 206 4 of of IN cord-302514-rstvf3mc 206 5 elongation elongation NN cord-302514-rstvf3mc 206 6 factor factor NN cord-302514-rstvf3mc 206 7 eEF1A2 eef1a2 NN cord-302514-rstvf3mc 206 8 in in IN cord-302514-rstvf3mc 206 9 ovarian ovarian JJ cord-302514-rstvf3mc 206 10 cancer cancer NN cord-302514-rstvf3mc 206 11 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 206 12 as as IN cord-302514-rstvf3mc 206 13 a a DT cord-302514-rstvf3mc 206 14 putative putative JJ cord-302514-rstvf3mc 206 15 oncogene oncogene NN cord-302514-rstvf3mc 207 1 The the DT cord-302514-rstvf3mc 207 2 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 207 3 translation translation NN cord-302514-rstvf3mc 207 4 elongation elongation NN cord-302514-rstvf3mc 207 5 factor factor NN cord-302514-rstvf3mc 207 6 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 207 7 induces induce VBZ cord-302514-rstvf3mc 207 8 neoplastic neoplastic JJ cord-302514-rstvf3mc 207 9 properties property NNS cord-302514-rstvf3mc 207 10 and and CC cord-302514-rstvf3mc 207 11 mediates mediate VBZ cord-302514-rstvf3mc 207 12 tumorigenic tumorigenic JJ cord-302514-rstvf3mc 207 13 effects effect NNS cord-302514-rstvf3mc 207 14 of of IN cord-302514-rstvf3mc 207 15 ZNF217 ZNF217 NNP cord-302514-rstvf3mc 207 16 in in IN cord-302514-rstvf3mc 207 17 precursor precursor NN cord-302514-rstvf3mc 207 18 cells cell NNS cord-302514-rstvf3mc 207 19 of of IN cord-302514-rstvf3mc 207 20 human human JJ cord-302514-rstvf3mc 207 21 ovarian ovarian JJ cord-302514-rstvf3mc 207 22 carcinomas carcinoma NNS cord-302514-rstvf3mc 207 23 Cancer cancer NN cord-302514-rstvf3mc 207 24 chemopreventive chemopreventive JJ cord-302514-rstvf3mc 207 25 and and CC cord-302514-rstvf3mc 207 26 therapeutic therapeutic JJ cord-302514-rstvf3mc 207 27 potential potential NN cord-302514-rstvf3mc 207 28 of of IN cord-302514-rstvf3mc 207 29 resveratrol resveratrol NN cord-302514-rstvf3mc 207 30 : : : cord-302514-rstvf3mc 207 31 mechanistic mechanistic JJ cord-302514-rstvf3mc 207 32 perspectives perspective NNS cord-302514-rstvf3mc 207 33 Resveratrol Resveratrol NNP cord-302514-rstvf3mc 207 34 , , , cord-302514-rstvf3mc 207 35 a a DT cord-302514-rstvf3mc 207 36 sirtuin sirtuin NN cord-302514-rstvf3mc 207 37 1 1 CD cord-302514-rstvf3mc 207 38 activator activator NN cord-302514-rstvf3mc 207 39 , , , cord-302514-rstvf3mc 208 1 increases increase VBZ cord-302514-rstvf3mc 208 2 IL-6 IL-6 NNP cord-302514-rstvf3mc 208 3 production production NN cord-302514-rstvf3mc 208 4 by by IN cord-302514-rstvf3mc 208 5 peripheral peripheral JJ cord-302514-rstvf3mc 208 6 blood blood NN cord-302514-rstvf3mc 208 7 mononuclear mononuclear NN cord-302514-rstvf3mc 208 8 cells cell NNS cord-302514-rstvf3mc 208 9 of of IN cord-302514-rstvf3mc 208 10 patients patient NNS cord-302514-rstvf3mc 208 11 with with IN cord-302514-rstvf3mc 208 12 knee knee NN cord-302514-rstvf3mc 208 13 osteoarthritis osteoarthritis NN cord-302514-rstvf3mc 209 1 Resveratrol resveratrol NN cord-302514-rstvf3mc 209 2 suppresses suppress VBZ cord-302514-rstvf3mc 209 3 growth growth NN cord-302514-rstvf3mc 209 4 of of IN cord-302514-rstvf3mc 209 5 human human JJ cord-302514-rstvf3mc 209 6 ovarian ovarian JJ cord-302514-rstvf3mc 209 7 cancer cancer NN cord-302514-rstvf3mc 209 8 cells cell NNS cord-302514-rstvf3mc 209 9 in in IN cord-302514-rstvf3mc 209 10 culture culture NN cord-302514-rstvf3mc 209 11 and and CC cord-302514-rstvf3mc 209 12 in in IN cord-302514-rstvf3mc 209 13 a a DT cord-302514-rstvf3mc 209 14 murine murine JJ cord-302514-rstvf3mc 209 15 xenograft xenograft NN cord-302514-rstvf3mc 209 16 model model NN cord-302514-rstvf3mc 209 17 : : : cord-302514-rstvf3mc 209 18 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 209 19 elongation elongation NN cord-302514-rstvf3mc 209 20 factor factor NN cord-302514-rstvf3mc 209 21 1A2 1a2 CD cord-302514-rstvf3mc 209 22 as as IN cord-302514-rstvf3mc 209 23 a a DT cord-302514-rstvf3mc 209 24 potential potential JJ cord-302514-rstvf3mc 209 25 target target NN cord-302514-rstvf3mc 209 26 Cancer cancer NN cord-302514-rstvf3mc 209 27 statistics statistic NNS cord-302514-rstvf3mc 209 28 Comparison comparison NN cord-302514-rstvf3mc 209 29 of of IN cord-302514-rstvf3mc 209 30 time time NN cord-302514-rstvf3mc 209 31 trends trend NNS cord-302514-rstvf3mc 209 32 in in IN cord-302514-rstvf3mc 209 33 lung lung NN cord-302514-rstvf3mc 209 34 cancer cancer NN cord-302514-rstvf3mc 209 35 mortality mortality NN cord-302514-rstvf3mc 209 36 ( ( -LRB- cord-302514-rstvf3mc 209 37 1990 1990 CD cord-302514-rstvf3mc 209 38 - - SYM cord-302514-rstvf3mc 209 39 2006 2006 CD cord-302514-rstvf3mc 209 40 ) ) -RRB- cord-302514-rstvf3mc 209 41 in in IN cord-302514-rstvf3mc 209 42 the the DT cord-302514-rstvf3mc 209 43 world world NN cord-302514-rstvf3mc 209 44 , , , cord-302514-rstvf3mc 209 45 from from IN cord-302514-rstvf3mc 209 46 the the DT cord-302514-rstvf3mc 209 47 WHO WHO NNP cord-302514-rstvf3mc 209 48 mortality mortality NN cord-302514-rstvf3mc 209 49 database database NN cord-302514-rstvf3mc 209 50 Establishment Establishment NNP cord-302514-rstvf3mc 209 51 and and CC cord-302514-rstvf3mc 209 52 expression expression NN cord-302514-rstvf3mc 209 53 profiling profiling NN cord-302514-rstvf3mc 209 54 of of IN cord-302514-rstvf3mc 209 55 new new JJ cord-302514-rstvf3mc 209 56 lung lung NN cord-302514-rstvf3mc 209 57 cancer cancer NN cord-302514-rstvf3mc 209 58 cell cell NN cord-302514-rstvf3mc 209 59 lines line NNS cord-302514-rstvf3mc 209 60 from from IN cord-302514-rstvf3mc 209 61 Chinese chinese JJ cord-302514-rstvf3mc 209 62 smokers smoker NNS cord-302514-rstvf3mc 209 63 and and CC cord-302514-rstvf3mc 209 64 lifetime lifetime NN cord-302514-rstvf3mc 209 65 never never RB cord-302514-rstvf3mc 209 66 - - HYPH cord-302514-rstvf3mc 209 67 smokers smoker NNS cord-302514-rstvf3mc 209 68 Molecular molecular JJ cord-302514-rstvf3mc 209 69 pathology pathology NN cord-302514-rstvf3mc 209 70 in in IN cord-302514-rstvf3mc 209 71 early early JJ cord-302514-rstvf3mc 209 72 hepatocarcinogenesis hepatocarcinogenesis NN cord-302514-rstvf3mc 209 73 CT CT NNP cord-302514-rstvf3mc 209 74 and and CC cord-302514-rstvf3mc 209 75 MRI MRI NNP cord-302514-rstvf3mc 209 76 of of IN cord-302514-rstvf3mc 209 77 hepatocellular hepatocellular JJ cord-302514-rstvf3mc 209 78 carcinoma carcinoma NN cord-302514-rstvf3mc 209 79 : : : cord-302514-rstvf3mc 209 80 an an DT cord-302514-rstvf3mc 209 81 update update NN cord-302514-rstvf3mc 209 82 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 209 83 inactivates inactivate VBZ cord-302514-rstvf3mc 209 84 p53 p53 NN cord-302514-rstvf3mc 209 85 by by IN cord-302514-rstvf3mc 209 86 way way NN cord-302514-rstvf3mc 209 87 of of IN cord-302514-rstvf3mc 209 88 PI3K PI3K NNP cord-302514-rstvf3mc 209 89 / / SYM cord-302514-rstvf3mc 209 90 AKT AKT NNP cord-302514-rstvf3mc 209 91 / / SYM cord-302514-rstvf3mc 209 92 mTOR mtor JJ cord-302514-rstvf3mc 209 93 - - HYPH cord-302514-rstvf3mc 209 94 dependent dependent JJ cord-302514-rstvf3mc 209 95 stabilization stabilization NN cord-302514-rstvf3mc 209 96 of of IN cord-302514-rstvf3mc 209 97 MDM4 MDM4 NNP cord-302514-rstvf3mc 209 98 in in IN cord-302514-rstvf3mc 209 99 hepatocellular hepatocellular JJ cord-302514-rstvf3mc 209 100 carcinoma carcinoma NN cord-302514-rstvf3mc 209 101 Hepatocellular Hepatocellular NNP cord-302514-rstvf3mc 209 102 carcinoma carcinoma NN cord-302514-rstvf3mc 209 103 pathogenesis pathogenesis NN cord-302514-rstvf3mc 209 104 : : : cord-302514-rstvf3mc 209 105 from from IN cord-302514-rstvf3mc 209 106 genes gene NNS cord-302514-rstvf3mc 209 107 to to IN cord-302514-rstvf3mc 209 108 environment environment NN cord-302514-rstvf3mc 209 109 Pancreatic pancreatic JJ cord-302514-rstvf3mc 209 110 cancer cancer NN cord-302514-rstvf3mc 210 1 The the DT cord-302514-rstvf3mc 210 2 epidemiology epidemiology NN cord-302514-rstvf3mc 210 3 of of IN cord-302514-rstvf3mc 210 4 pancreatic pancreatic JJ cord-302514-rstvf3mc 210 5 cancer cancer NN cord-302514-rstvf3mc 210 6 in in IN cord-302514-rstvf3mc 210 7 the the DT cord-302514-rstvf3mc 210 8 United United NNP cord-302514-rstvf3mc 210 9 States States NNP cord-302514-rstvf3mc 210 10 : : : cord-302514-rstvf3mc 210 11 changes change NNS cord-302514-rstvf3mc 210 12 below below IN cord-302514-rstvf3mc 210 13 the the DT cord-302514-rstvf3mc 210 14 surface surface NN cord-302514-rstvf3mc 210 15 Regulation regulation NN cord-302514-rstvf3mc 210 16 and and CC cord-302514-rstvf3mc 210 17 functional functional JJ cord-302514-rstvf3mc 210 18 role role NN cord-302514-rstvf3mc 210 19 of of IN cord-302514-rstvf3mc 210 20 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 210 21 in in IN cord-302514-rstvf3mc 210 22 pancreatic pancreatic JJ cord-302514-rstvf3mc 210 23 carcinoma carcinoma NN cord-302514-rstvf3mc 210 24 eEF1A2 eef1a2 NN cord-302514-rstvf3mc 210 25 promotes promote VBZ cord-302514-rstvf3mc 210 26 cell cell NN cord-302514-rstvf3mc 210 27 migration migration NN cord-302514-rstvf3mc 210 28 , , , cord-302514-rstvf3mc 210 29 invasion invasion NN cord-302514-rstvf3mc 210 30 and and CC cord-302514-rstvf3mc 210 31 metastasis metastasis NN cord-302514-rstvf3mc 210 32 in in IN cord-302514-rstvf3mc 210 33 pancreatic pancreatic JJ cord-302514-rstvf3mc 210 34 cancer cancer NN cord-302514-rstvf3mc 210 35 by by IN cord-302514-rstvf3mc 210 36 upregulating upregulate VBG cord-302514-rstvf3mc 210 37 MMP-9 MMP-9 NNP cord-302514-rstvf3mc 210 38 expression expression NN cord-302514-rstvf3mc 210 39 through through IN cord-302514-rstvf3mc 210 40 Akt Akt NNP cord-302514-rstvf3mc 210 41 activation activation NN cord-302514-rstvf3mc 210 42 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 210 43 protein protein NN cord-302514-rstvf3mc 210 44 expression expression NN cord-302514-rstvf3mc 210 45 correlates correlate VBZ cord-302514-rstvf3mc 210 46 with with IN cord-302514-rstvf3mc 210 47 lymph lymph NN cord-302514-rstvf3mc 210 48 node node NN cord-302514-rstvf3mc 210 49 metastasis metastasis NN cord-302514-rstvf3mc 210 50 and and CC cord-302514-rstvf3mc 210 51 decreased decrease VBD cord-302514-rstvf3mc 210 52 survival survival NN cord-302514-rstvf3mc 210 53 in in IN cord-302514-rstvf3mc 210 54 pancreatic pancreatic JJ cord-302514-rstvf3mc 210 55 ductal ductal JJ cord-302514-rstvf3mc 210 56 adenocarcinoma adenocarcinoma NN cord-302514-rstvf3mc 210 57 Apoptosis apoptosis NN cord-302514-rstvf3mc 210 58 - - HYPH cord-302514-rstvf3mc 210 59 induced induce VBN cord-302514-rstvf3mc 210 60 compensatory compensatory JJ cord-302514-rstvf3mc 210 61 proliferation proliferation NN cord-302514-rstvf3mc 210 62 . . . cord-302514-rstvf3mc 211 1 The the DT cord-302514-rstvf3mc 211 2 cell cell NN cord-302514-rstvf3mc 211 3 is be VBZ cord-302514-rstvf3mc 211 4 dead dead JJ cord-302514-rstvf3mc 211 5 . . . cord-302514-rstvf3mc 212 1 Long long RB cord-302514-rstvf3mc 212 2 live live VB cord-302514-rstvf3mc 212 3 the the DT cord-302514-rstvf3mc 212 4 cell cell NN cord-302514-rstvf3mc 212 5 ! ! . cord-302514-rstvf3mc 213 1 Bcl-2-regulated bcl-2-regulated JJ cord-302514-rstvf3mc 213 2 apoptosis apoptosis NN cord-302514-rstvf3mc 213 3 : : : cord-302514-rstvf3mc 214 1 mechanism mechanism NN cord-302514-rstvf3mc 214 2 and and CC cord-302514-rstvf3mc 214 3 therapeutic therapeutic JJ cord-302514-rstvf3mc 214 4 potential potential JJ cord-302514-rstvf3mc 214 5 Mouse mouse NN cord-302514-rstvf3mc 214 6 translation translation NN cord-302514-rstvf3mc 214 7 elongation elongation NN cord-302514-rstvf3mc 214 8 factor factor NN cord-302514-rstvf3mc 214 9 eEF1A-2 eef1a-2 NN cord-302514-rstvf3mc 214 10 interacts interact VBZ cord-302514-rstvf3mc 214 11 with with IN cord-302514-rstvf3mc 214 12 Prdx Prdx NNP cord-302514-rstvf3mc 214 13 - - : cord-302514-rstvf3mc 214 14 I -PRON- PRP cord-302514-rstvf3mc 214 15 to to TO cord-302514-rstvf3mc 214 16 protect protect VB cord-302514-rstvf3mc 214 17 cells cell NNS cord-302514-rstvf3mc 214 18 against against IN cord-302514-rstvf3mc 214 19 apoptotic apoptotic JJ cord-302514-rstvf3mc 214 20 death death NN cord-302514-rstvf3mc 214 21 induced induce VBN cord-302514-rstvf3mc 214 22 by by IN cord-302514-rstvf3mc 214 23 oxidative oxidative JJ cord-302514-rstvf3mc 214 24 stress stress NN cord-302514-rstvf3mc 214 25 Blockade Blockade NNP cord-302514-rstvf3mc 214 26 of of IN cord-302514-rstvf3mc 214 27 BFA BFA NNP cord-302514-rstvf3mc 214 28 - - HYPH cord-302514-rstvf3mc 214 29 mediated mediate VBN cord-302514-rstvf3mc 214 30 apoptosis apoptosis NN cord-302514-rstvf3mc 214 31 in in IN cord-302514-rstvf3mc 214 32 macrophages macrophage NNS cord-302514-rstvf3mc 214 33 by by IN cord-302514-rstvf3mc 214 34 the the DT cord-302514-rstvf3mc 214 35 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 214 36 Nef Nef NNP cord-302514-rstvf3mc 214 37 protein protein NN cord-302514-rstvf3mc 214 38 Rapid Rapid NNP cord-302514-rstvf3mc 214 39 up up IN cord-302514-rstvf3mc 214 40 - - HYPH cord-302514-rstvf3mc 214 41 regulation regulation NN cord-302514-rstvf3mc 214 42 of of IN cord-302514-rstvf3mc 214 43 peptide peptide NN cord-302514-rstvf3mc 214 44 elongation elongation NN cord-302514-rstvf3mc 214 45 factor factor NN cord-302514-rstvf3mc 215 1 EF-1alpha EF-1alpha NNP cord-302514-rstvf3mc 215 2 protein protein NN cord-302514-rstvf3mc 215 3 levels level NNS cord-302514-rstvf3mc 215 4 is be VBZ cord-302514-rstvf3mc 215 5 an an DT cord-302514-rstvf3mc 215 6 immediate immediate JJ cord-302514-rstvf3mc 215 7 early early JJ cord-302514-rstvf3mc 215 8 event event NN cord-302514-rstvf3mc 215 9 during during IN cord-302514-rstvf3mc 215 10 oxidative oxidative JJ cord-302514-rstvf3mc 215 11 stress stress NN cord-302514-rstvf3mc 215 12 - - HYPH cord-302514-rstvf3mc 215 13 induced induce VBN cord-302514-rstvf3mc 215 14 apoptosis apoptosis NN cord-302514-rstvf3mc 215 15 Inactivation inactivation NN cord-302514-rstvf3mc 215 16 of of IN cord-302514-rstvf3mc 215 17 a a DT cord-302514-rstvf3mc 215 18 peroxiredoxin peroxiredoxin NN cord-302514-rstvf3mc 215 19 by by IN cord-302514-rstvf3mc 215 20 hydrogen hydrogen NN cord-302514-rstvf3mc 215 21 peroxide peroxide NN cord-302514-rstvf3mc 215 22 is be VBZ cord-302514-rstvf3mc 215 23 critical critical JJ cord-302514-rstvf3mc 215 24 for for IN cord-302514-rstvf3mc 215 25 thioredoxin thioredoxin NN cord-302514-rstvf3mc 215 26 - - HYPH cord-302514-rstvf3mc 215 27 mediated mediate VBN cord-302514-rstvf3mc 215 28 repair repair NN cord-302514-rstvf3mc 215 29 of of IN cord-302514-rstvf3mc 215 30 oxidized oxidized JJ cord-302514-rstvf3mc 215 31 proteins protein NNS cord-302514-rstvf3mc 215 32 and and CC cord-302514-rstvf3mc 215 33 cell cell NN cord-302514-rstvf3mc 215 34 survival survival NN cord-302514-rstvf3mc 216 1 Elongation elongation NN cord-302514-rstvf3mc 216 2 factor-1 factor-1 NNP cord-302514-rstvf3mc 216 3 alpha alpha NN cord-302514-rstvf3mc 216 4 is be VBZ cord-302514-rstvf3mc 216 5 a a DT cord-302514-rstvf3mc 216 6 selective selective JJ cord-302514-rstvf3mc 216 7 regulator regulator NN cord-302514-rstvf3mc 216 8 of of IN cord-302514-rstvf3mc 216 9 growth growth NN cord-302514-rstvf3mc 216 10 factor factor NN cord-302514-rstvf3mc 216 11 withdrawal withdrawal NN cord-302514-rstvf3mc 216 12 and and CC cord-302514-rstvf3mc 216 13 ER ER NNP cord-302514-rstvf3mc 216 14 stress stress NN cord-302514-rstvf3mc 216 15 - - HYPH cord-302514-rstvf3mc 216 16 induced induce VBN cord-302514-rstvf3mc 216 17 apoptosis apoptosis NN cord-302514-rstvf3mc 216 18 Translation translation NN cord-302514-rstvf3mc 216 19 elongation elongation NN cord-302514-rstvf3mc 216 20 factor factor NN cord-302514-rstvf3mc 217 1 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 217 2 is be VBZ cord-302514-rstvf3mc 217 3 essential essential JJ cord-302514-rstvf3mc 217 4 for for IN cord-302514-rstvf3mc 217 5 post post JJ cord-302514-rstvf3mc 217 6 - - JJ cord-302514-rstvf3mc 217 7 weaning weaning JJ cord-302514-rstvf3mc 217 8 survival survival NN cord-302514-rstvf3mc 217 9 in in IN cord-302514-rstvf3mc 217 10 mice mouse NNS cord-302514-rstvf3mc 218 1 The the DT cord-302514-rstvf3mc 218 2 lethal lethal JJ cord-302514-rstvf3mc 218 3 mutation mutation NN cord-302514-rstvf3mc 218 4 of of IN cord-302514-rstvf3mc 218 5 the the DT cord-302514-rstvf3mc 218 6 mouse mouse NN cord-302514-rstvf3mc 218 7 wasted waste VBN cord-302514-rstvf3mc 218 8 ( ( -LRB- cord-302514-rstvf3mc 218 9 wst wst NNP cord-302514-rstvf3mc 218 10 ) ) -RRB- cord-302514-rstvf3mc 218 11 is be VBZ cord-302514-rstvf3mc 218 12 a a DT cord-302514-rstvf3mc 218 13 deletion deletion NN cord-302514-rstvf3mc 218 14 that that WDT cord-302514-rstvf3mc 218 15 abolishes abolish VBZ cord-302514-rstvf3mc 218 16 expression expression NN cord-302514-rstvf3mc 218 17 of of IN cord-302514-rstvf3mc 218 18 a a DT cord-302514-rstvf3mc 218 19 tissue tissue NN cord-302514-rstvf3mc 218 20 - - HYPH cord-302514-rstvf3mc 218 21 specific specific JJ cord-302514-rstvf3mc 218 22 isoform isoform NN cord-302514-rstvf3mc 218 23 of of IN cord-302514-rstvf3mc 218 24 translation translation NN cord-302514-rstvf3mc 218 25 elongation elongation NN cord-302514-rstvf3mc 218 26 factor factor NN cord-302514-rstvf3mc 218 27 1alpha 1alpha CD cord-302514-rstvf3mc 218 28 , , , cord-302514-rstvf3mc 218 29 encoded encode VBN cord-302514-rstvf3mc 218 30 by by IN cord-302514-rstvf3mc 218 31 the the DT cord-302514-rstvf3mc 218 32 Eef1a2 Eef1a2 NNP cord-302514-rstvf3mc 218 33 gene gene NN cord-302514-rstvf3mc 219 1 The the DT cord-302514-rstvf3mc 219 2 wst wst NNP cord-302514-rstvf3mc 219 3 gene gene NN cord-302514-rstvf3mc 219 4 regulates regulate VBZ cord-302514-rstvf3mc 219 5 multiple multiple JJ cord-302514-rstvf3mc 219 6 forms form NNS cord-302514-rstvf3mc 219 7 of of IN cord-302514-rstvf3mc 219 8 thymocyte thymocyte NN cord-302514-rstvf3mc 219 9 apoptosis apoptosis NN cord-302514-rstvf3mc 219 10 De De NNP cord-302514-rstvf3mc 219 11 novo novo NNP cord-302514-rstvf3mc 219 12 eEF1A2 eEF1A2 NNP cord-302514-rstvf3mc 219 13 mutations mutation NNS cord-302514-rstvf3mc 219 14 in in IN cord-302514-rstvf3mc 219 15 patients patient NNS cord-302514-rstvf3mc 219 16 with with IN cord-302514-rstvf3mc 219 17 characteristic characteristic JJ cord-302514-rstvf3mc 219 18 facial facial JJ cord-302514-rstvf3mc 219 19 features feature NNS cord-302514-rstvf3mc 219 20 , , , cord-302514-rstvf3mc 219 21 intellectual intellectual JJ cord-302514-rstvf3mc 219 22 disability disability NN cord-302514-rstvf3mc 219 23 , , , cord-302514-rstvf3mc 219 24 autistic autistic JJ cord-302514-rstvf3mc 219 25 behaviors behavior NNS cord-302514-rstvf3mc 219 26 and and CC cord-302514-rstvf3mc 219 27 epilepsy epilepsy NN cord-302514-rstvf3mc 219 28 Peptide Peptide NNP cord-302514-rstvf3mc 219 29 elongation elongation NN cord-302514-rstvf3mc 219 30 factor factor NN cord-302514-rstvf3mc 219 31 eEF1A-2 eEF1A-2 NNP cord-302514-rstvf3mc 219 32 / / SYM cord-302514-rstvf3mc 219 33 S1 S1 NNP cord-302514-rstvf3mc 219 34 expression expression NN cord-302514-rstvf3mc 219 35 in in IN cord-302514-rstvf3mc 219 36 cultured cultured JJ cord-302514-rstvf3mc 219 37 differentiated differentiated JJ cord-302514-rstvf3mc 219 38 myotubes myotube NNS cord-302514-rstvf3mc 219 39 and and CC cord-302514-rstvf3mc 219 40 its -PRON- PRP$ cord-302514-rstvf3mc 219 41 protective protective JJ cord-302514-rstvf3mc 219 42 effect effect NN cord-302514-rstvf3mc 219 43 against against IN cord-302514-rstvf3mc 219 44 caspase-3-mediated caspase-3-mediated JJ cord-302514-rstvf3mc 219 45 apoptosis apoptosis NN cord-302514-rstvf3mc 219 46 eEF1A2 eef1a2 NN cord-302514-rstvf3mc 219 47 and and CC cord-302514-rstvf3mc 219 48 neuronal neuronal JJ cord-302514-rstvf3mc 219 49 degeneration degeneration NN cord-302514-rstvf3mc 220 1 The the DT cord-302514-rstvf3mc 220 2 unexpected unexpected JJ cord-302514-rstvf3mc 220 3 roles role NNS cord-302514-rstvf3mc 220 4 of of IN cord-302514-rstvf3mc 220 5 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 220 6 translation translation NN cord-302514-rstvf3mc 220 7 elongation elongation NN cord-302514-rstvf3mc 220 8 factors factor NNS cord-302514-rstvf3mc 220 9 in in IN cord-302514-rstvf3mc 220 10 RNA RNA NNP cord-302514-rstvf3mc 220 11 virus virus NN cord-302514-rstvf3mc 220 12 replication replication NN cord-302514-rstvf3mc 220 13 and and CC cord-302514-rstvf3mc 220 14 pathogenesis pathogenesis NN cord-302514-rstvf3mc 220 15 Translation translation NN cord-302514-rstvf3mc 220 16 elongation elongation NN cord-302514-rstvf3mc 220 17 factor factor NN cord-302514-rstvf3mc 220 18 1-alpha 1-alpha CD cord-302514-rstvf3mc 220 19 interacts interact VBZ cord-302514-rstvf3mc 220 20 specifically specifically RB cord-302514-rstvf3mc 220 21 with with IN cord-302514-rstvf3mc 220 22 the the DT cord-302514-rstvf3mc 220 23 human human JJ cord-302514-rstvf3mc 220 24 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 220 25 virus virus NN cord-302514-rstvf3mc 220 26 type type NN cord-302514-rstvf3mc 220 27 1 1 CD cord-302514-rstvf3mc 220 28 Gag Gag NNP cord-302514-rstvf3mc 220 29 polyprotein polyprotein NN cord-302514-rstvf3mc 221 1 Actinbinding actinbinde VBG cord-302514-rstvf3mc 221 2 cellular cellular JJ cord-302514-rstvf3mc 221 3 proteins protein NNS cord-302514-rstvf3mc 221 4 inside inside IN cord-302514-rstvf3mc 221 5 human human JJ cord-302514-rstvf3mc 221 6 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 221 7 virus virus NN cord-302514-rstvf3mc 221 8 type type NN cord-302514-rstvf3mc 221 9 1 1 CD cord-302514-rstvf3mc 221 10 Eukaryotic eukaryotic JJ cord-302514-rstvf3mc 221 11 elongation elongation NN cord-302514-rstvf3mc 221 12 factor factor NN cord-302514-rstvf3mc 221 13 1 1 CD cord-302514-rstvf3mc 221 14 complex complex JJ cord-302514-rstvf3mc 221 15 subunits subunit NNS cord-302514-rstvf3mc 221 16 are be VBP cord-302514-rstvf3mc 221 17 critical critical JJ cord-302514-rstvf3mc 221 18 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 221 19 reverse reverse NN cord-302514-rstvf3mc 221 20 transcription transcription NN cord-302514-rstvf3mc 221 21 cofactors cofactor NNS cord-302514-rstvf3mc 221 22 Identification identification NN cord-302514-rstvf3mc 221 23 of of IN cord-302514-rstvf3mc 221 24 cellular cellular JJ cord-302514-rstvf3mc 221 25 factors factor NNS cord-302514-rstvf3mc 221 26 binding bind VBG cord-302514-rstvf3mc 221 27 to to IN cord-302514-rstvf3mc 221 28 acetylated acetylated JJ cord-302514-rstvf3mc 221 29 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 221 30 integrase integrase NN cord-302514-rstvf3mc 221 31 Functional functional JJ cord-302514-rstvf3mc 221 32 interactions interaction NNS cord-302514-rstvf3mc 221 33 of of IN cord-302514-rstvf3mc 221 34 human human JJ cord-302514-rstvf3mc 221 35 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 221 36 virus virus NN cord-302514-rstvf3mc 221 37 type type NN cord-302514-rstvf3mc 221 38 1 1 CD cord-302514-rstvf3mc 221 39 integrase integrase NN cord-302514-rstvf3mc 221 40 with with IN cord-302514-rstvf3mc 221 41 human human NN cord-302514-rstvf3mc 221 42 and and CC cord-302514-rstvf3mc 221 43 yeast yeast NN cord-302514-rstvf3mc 221 44 HSP60 HSP60 NNP cord-302514-rstvf3mc 221 45 Nef Nef NNP cord-302514-rstvf3mc 221 46 interaction interaction NN cord-302514-rstvf3mc 221 47 with with IN cord-302514-rstvf3mc 221 48 actin actin NN cord-302514-rstvf3mc 221 49 compromises compromise NNS cord-302514-rstvf3mc 221 50 human human JJ cord-302514-rstvf3mc 221 51 podocyte podocyte NNP cord-302514-rstvf3mc 221 52 actin actin NNP cord-302514-rstvf3mc 221 53 cytoskeletal cytoskeletal JJ cord-302514-rstvf3mc 221 54 integrity integrity NN cord-302514-rstvf3mc 221 55 Identification identification NN cord-302514-rstvf3mc 221 56 of of IN cord-302514-rstvf3mc 221 57 a a DT cord-302514-rstvf3mc 221 58 group group NN cord-302514-rstvf3mc 221 59 of of IN cord-302514-rstvf3mc 221 60 cellular cellular JJ cord-302514-rstvf3mc 221 61 cofactors cofactor NNS cord-302514-rstvf3mc 221 62 that that WDT cord-302514-rstvf3mc 221 63 stimulate stimulate VBP cord-302514-rstvf3mc 221 64 the the DT cord-302514-rstvf3mc 221 65 binding binding NN cord-302514-rstvf3mc 221 66 of of IN cord-302514-rstvf3mc 221 67 RNA RNA NNP cord-302514-rstvf3mc 221 68 polymerase polymerase NN cord-302514-rstvf3mc 221 69 II II NNP cord-302514-rstvf3mc 221 70 and and CC cord-302514-rstvf3mc 221 71 TRP-185 trp-185 DT cord-302514-rstvf3mc 221 72 to to IN cord-302514-rstvf3mc 221 73 human human JJ cord-302514-rstvf3mc 221 74 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 221 75 virus virus NN cord-302514-rstvf3mc 221 76 1 1 CD cord-302514-rstvf3mc 221 77 TAR tar NN cord-302514-rstvf3mc 221 78 RNA RNA NNP cord-302514-rstvf3mc 222 1 The the DT cord-302514-rstvf3mc 222 2 HIV-1 HIV-1 NNP cord-302514-rstvf3mc 222 3 Nef Nef NNP cord-302514-rstvf3mc 222 4 protein protein NN cord-302514-rstvf3mc 222 5 interacts interact VBZ cord-302514-rstvf3mc 222 6 with with IN cord-302514-rstvf3mc 222 7 two two CD cord-302514-rstvf3mc 222 8 components component NNS cord-302514-rstvf3mc 222 9 of of IN cord-302514-rstvf3mc 222 10 the the DT cord-302514-rstvf3mc 222 11 40S 40s CD cord-302514-rstvf3mc 222 12 small small JJ cord-302514-rstvf3mc 222 13 ribosomal ribosomal JJ cord-302514-rstvf3mc 222 14 subunit subunit NN cord-302514-rstvf3mc 222 15 , , , cord-302514-rstvf3mc 222 16 the the DT cord-302514-rstvf3mc 222 17 RPS10 RPS10 NNP cord-302514-rstvf3mc 222 18 protein protein NN cord-302514-rstvf3mc 222 19 and and CC cord-302514-rstvf3mc 222 20 the the DT cord-302514-rstvf3mc 222 21 18S 18S NNPS cord-302514-rstvf3mc 222 22 rRNA rRNA NNP cord-302514-rstvf3mc 222 23 Interaction Interaction NNP cord-302514-rstvf3mc 222 24 of of IN cord-302514-rstvf3mc 222 25 the the DT cord-302514-rstvf3mc 222 26 second second JJ cord-302514-rstvf3mc 222 27 coding coding NN cord-302514-rstvf3mc 222 28 exon exon NN cord-302514-rstvf3mc 222 29 of of IN cord-302514-rstvf3mc 222 30 Tat Tat NNP cord-302514-rstvf3mc 222 31 with with IN cord-302514-rstvf3mc 222 32 human human JJ cord-302514-rstvf3mc 222 33 EF-1 EF-1 NNP cord-302514-rstvf3mc 222 34 delta delta NN cord-302514-rstvf3mc 222 35 delineates delineate VBZ cord-302514-rstvf3mc 222 36 a a DT cord-302514-rstvf3mc 222 37 mechanism mechanism NN cord-302514-rstvf3mc 222 38 for for IN cord-302514-rstvf3mc 222 39 HIV-1-mediated hiv-1-mediated JJ cord-302514-rstvf3mc 222 40 shut shut NN cord-302514-rstvf3mc 222 41 - - HYPH cord-302514-rstvf3mc 222 42 off off NN cord-302514-rstvf3mc 222 43 of of IN cord-302514-rstvf3mc 222 44 host host NN cord-302514-rstvf3mc 222 45 mRNA mrna NN cord-302514-rstvf3mc 223 1 translation translation NN cord-302514-rstvf3mc 223 2 Hepatitis Hepatitis NNP cord-302514-rstvf3mc 223 3 B B NNP cord-302514-rstvf3mc 223 4 virus virus NN cord-302514-rstvf3mc 224 1 X x NN cord-302514-rstvf3mc 224 2 protein protein NN cord-302514-rstvf3mc 224 3 blocks block VBZ cord-302514-rstvf3mc 224 4 filamentous filamentous JJ cord-302514-rstvf3mc 224 5 actin actin NN cord-302514-rstvf3mc 224 6 bundles bundle NNS cord-302514-rstvf3mc 224 7 by by IN cord-302514-rstvf3mc 224 8 interaction interaction NN cord-302514-rstvf3mc 224 9 with with IN cord-302514-rstvf3mc 224 10 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 224 11 translation translation NN cord-302514-rstvf3mc 224 12 elongation elongation NN cord-302514-rstvf3mc 224 13 factor factor NN cord-302514-rstvf3mc 224 14 1 1 CD cord-302514-rstvf3mc 224 15 alpha alpha NN cord-302514-rstvf3mc 224 16 1 1 CD cord-302514-rstvf3mc 225 1 The the DT cord-302514-rstvf3mc 225 2 hepatitis hepatitis NN cord-302514-rstvf3mc 225 3 delta delta NNP cord-302514-rstvf3mc 225 4 virus virus NN cord-302514-rstvf3mc 225 5 RNA RNA NNP cord-302514-rstvf3mc 225 6 genome genome NN cord-302514-rstvf3mc 225 7 interacts interact VBZ cord-302514-rstvf3mc 225 8 with with IN cord-302514-rstvf3mc 225 9 eEF1A1 eEF1A1 NNP cord-302514-rstvf3mc 225 10 , , , cord-302514-rstvf3mc 225 11 p54(nrb p54(nrb NNP cord-302514-rstvf3mc 225 12 ) ) -RRB- cord-302514-rstvf3mc 226 1 Cutaneous cutaneous JJ cord-302514-rstvf3mc 226 2 human human JJ cord-302514-rstvf3mc 226 3 papillomavirus papillomavirus NN cord-302514-rstvf3mc 226 4 type type NN cord-302514-rstvf3mc 226 5 38 38 CD cord-302514-rstvf3mc 226 6 E7 E7 NNP cord-302514-rstvf3mc 226 7 regulates regulate VBZ cord-302514-rstvf3mc 226 8 actin actin NN cord-302514-rstvf3mc 226 9 cytoskeleton cytoskeleton NN cord-302514-rstvf3mc 226 10 structure structure NN cord-302514-rstvf3mc 226 11 for for IN cord-302514-rstvf3mc 226 12 increasing increase VBG cord-302514-rstvf3mc 226 13 cell cell NN cord-302514-rstvf3mc 226 14 proliferation proliferation NN cord-302514-rstvf3mc 226 15 through through IN cord-302514-rstvf3mc 226 16 CK2 CK2 NNP cord-302514-rstvf3mc 226 17 and and CC cord-302514-rstvf3mc 226 18 the the DT cord-302514-rstvf3mc 226 19 eukaryotic eukaryotic JJ cord-302514-rstvf3mc 226 20 elongation elongation NN cord-302514-rstvf3mc 226 21 factor factor NN cord-302514-rstvf3mc 226 22 1A 1a NN cord-302514-rstvf3mc 226 23 Translation translation NN cord-302514-rstvf3mc 226 24 elongation elongation NN cord-302514-rstvf3mc 227 1 factor-1 factor-1 NNP cord-302514-rstvf3mc 227 2 alpha alpha NN cord-302514-rstvf3mc 227 3 interacts interact VBZ cord-302514-rstvf3mc 227 4 with with IN cord-302514-rstvf3mc 227 5 the the DT cord-302514-rstvf3mc 227 6 3 3 CD cord-302514-rstvf3mc 227 7 ' ' POS cord-302514-rstvf3mc 227 8 stem stem NN cord-302514-rstvf3mc 227 9 - - HYPH cord-302514-rstvf3mc 227 10 loop loop NN cord-302514-rstvf3mc 227 11 region region NN cord-302514-rstvf3mc 227 12 of of IN cord-302514-rstvf3mc 227 13 West West NNP cord-302514-rstvf3mc 227 14 Nile Nile NNP cord-302514-rstvf3mc 227 15 virus virus NN cord-302514-rstvf3mc 227 16 genomic genomic JJ cord-302514-rstvf3mc 227 17 RNA RNA NNP cord-302514-rstvf3mc 227 18 Interaction Interaction NNP cord-302514-rstvf3mc 227 19 between between IN cord-302514-rstvf3mc 227 20 the the DT cord-302514-rstvf3mc 227 21 cellular cellular JJ cord-302514-rstvf3mc 227 22 protein protein NN cord-302514-rstvf3mc 227 23 eEF1A eef1a CD cord-302514-rstvf3mc 227 24 and and CC cord-302514-rstvf3mc 227 25 the the DT cord-302514-rstvf3mc 227 26 3'-terminal 3'-terminal JJ cord-302514-rstvf3mc 227 27 stem stem NN cord-302514-rstvf3mc 227 28 - - HYPH cord-302514-rstvf3mc 227 29 loop loop NN cord-302514-rstvf3mc 227 30 of of IN cord-302514-rstvf3mc 227 31 West West NNP cord-302514-rstvf3mc 227 32 Nile Nile NNP cord-302514-rstvf3mc 227 33 virus virus NN cord-302514-rstvf3mc 227 34 genomic genomic JJ cord-302514-rstvf3mc 227 35 RNA RNA NNP cord-302514-rstvf3mc 228 1 facilitates facilitate VBZ cord-302514-rstvf3mc 228 2 viral viral JJ cord-302514-rstvf3mc 228 3 minus minus JJ cord-302514-rstvf3mc 228 4 - - HYPH cord-302514-rstvf3mc 228 5 strand strand NN cord-302514-rstvf3mc 228 6 RNA RNA NNP cord-302514-rstvf3mc 228 7 synthesis synthesis NN cord-302514-rstvf3mc 228 8 Reduced reduce VBN cord-302514-rstvf3mc 228 9 sphingosine sphingosine NNP cord-302514-rstvf3mc 228 10 kinase kinase NN cord-302514-rstvf3mc 228 11 1 1 CD cord-302514-rstvf3mc 228 12 activity activity NN cord-302514-rstvf3mc 228 13 in in IN cord-302514-rstvf3mc 228 14 dengue dengue NN cord-302514-rstvf3mc 228 15 virus virus NN cord-302514-rstvf3mc 229 1 type-2 type-2 NN cord-302514-rstvf3mc 229 2 infected infected JJ cord-302514-rstvf3mc 229 3 cells cell NNS cord-302514-rstvf3mc 229 4 can can MD cord-302514-rstvf3mc 229 5 be be VB cord-302514-rstvf3mc 229 6 mediated mediate VBN cord-302514-rstvf3mc 229 7 by by IN cord-302514-rstvf3mc 229 8 the the DT cord-302514-rstvf3mc 229 9 3 3 CD cord-302514-rstvf3mc 229 10 ' ' POS cord-302514-rstvf3mc 229 11 untranslated untranslated JJ cord-302514-rstvf3mc 229 12 region region NN cord-302514-rstvf3mc 229 13 of of IN cord-302514-rstvf3mc 229 14 dengue dengue NN cord-302514-rstvf3mc 229 15 virus virus NN cord-302514-rstvf3mc 229 16 type-2 type-2 NNP cord-302514-rstvf3mc 229 17 RNA RNA NNP cord-302514-rstvf3mc 229 18 EF1A EF1A NNS cord-302514-rstvf3mc 229 19 interacting interact VBG cord-302514-rstvf3mc 229 20 with with IN cord-302514-rstvf3mc 229 21 nucleocapsid nucleocapsid NNP cord-302514-rstvf3mc 229 22 protein protein NN cord-302514-rstvf3mc 229 23 of of IN cord-302514-rstvf3mc 229 24 transmissible transmissible JJ cord-302514-rstvf3mc 229 25 gastroenteritis gastroenteritis JJ cord-302514-rstvf3mc 229 26 coronavirus coronavirus NN cord-302514-rstvf3mc 229 27 and and CC cord-302514-rstvf3mc 229 28 plays play VBZ cord-302514-rstvf3mc 229 29 a a DT cord-302514-rstvf3mc 229 30 role role NN cord-302514-rstvf3mc 229 31 in in IN cord-302514-rstvf3mc 229 32 virus virus NN cord-302514-rstvf3mc 229 33 replication replication NN cord-302514-rstvf3mc 229 34 Analysis Analysis NNP cord-302514-rstvf3mc 229 35 of of IN cord-302514-rstvf3mc 229 36 virion virion NN cord-302514-rstvf3mc 229 37 associated associate VBD cord-302514-rstvf3mc 229 38 host host NN cord-302514-rstvf3mc 229 39 proteins protein NNS cord-302514-rstvf3mc 229 40 in in IN cord-302514-rstvf3mc 229 41 vesicular vesicular JJ cord-302514-rstvf3mc 229 42 stomatitis stomatitis NN cord-302514-rstvf3mc 229 43 virus virus NN cord-302514-rstvf3mc 229 44 using use VBG cord-302514-rstvf3mc 229 45 a a DT cord-302514-rstvf3mc 229 46 proteomics proteomic NNS cord-302514-rstvf3mc 229 47 approach approach NN cord-302514-rstvf3mc 229 48 Vaccinia Vaccinia NNP cord-302514-rstvf3mc 229 49 virus virus NN cord-302514-rstvf3mc 229 50 proteome proteome NN cord-302514-rstvf3mc 229 51 : : : cord-302514-rstvf3mc 229 52 identification identification NN cord-302514-rstvf3mc 229 53 of of IN cord-302514-rstvf3mc 229 54 proteins protein NNS cord-302514-rstvf3mc 229 55 in in IN cord-302514-rstvf3mc 229 56 vaccinia vaccinia NN cord-302514-rstvf3mc 229 57 virus virus NN cord-302514-rstvf3mc 229 58 intracellular intracellular JJ cord-302514-rstvf3mc 229 59 mature mature JJ cord-302514-rstvf3mc 229 60 virion virion NN cord-302514-rstvf3mc 229 61 particles particle NNS cord-302514-rstvf3mc 229 62 Protein Protein NNP cord-302514-rstvf3mc 229 63 composition composition NN cord-302514-rstvf3mc 229 64 of of IN cord-302514-rstvf3mc 229 65 the the DT cord-302514-rstvf3mc 229 66 vaccinia vaccinia NN cord-302514-rstvf3mc 229 67 virus virus NN cord-302514-rstvf3mc 229 68 mature mature JJ cord-302514-rstvf3mc 229 69 virion virion NN cord-302514-rstvf3mc 229 70 Identification identification NN cord-302514-rstvf3mc 229 71 of of IN cord-302514-rstvf3mc 229 72 proteins protein NNS cord-302514-rstvf3mc 229 73 associated associate VBN cord-302514-rstvf3mc 229 74 with with IN cord-302514-rstvf3mc 229 75 murine murine JJ cord-302514-rstvf3mc 229 76 cytomegalovirus cytomegalovirus NN cord-302514-rstvf3mc 229 77 virions virion NNS cord-302514-rstvf3mc 229 78 Identification Identification NNP cord-302514-rstvf3mc 229 79 of of IN cord-302514-rstvf3mc 229 80 proteins protein NNS cord-302514-rstvf3mc 229 81 in in IN cord-302514-rstvf3mc 229 82 human human JJ cord-302514-rstvf3mc 229 83 cytomegalovirus cytomegalovirus NN cord-302514-rstvf3mc 229 84 ( ( -LRB- cord-302514-rstvf3mc 229 85 HCMV HCMV NNP cord-302514-rstvf3mc 229 86 ) ) -RRB- cord-302514-rstvf3mc 229 87 particles particle NNS cord-302514-rstvf3mc 229 88 : : : cord-302514-rstvf3mc 229 89 the the DT cord-302514-rstvf3mc 229 90 HCMV HCMV NNP cord-302514-rstvf3mc 229 91 proteome proteome NN cord-302514-rstvf3mc 229 92 Proteomics Proteomics NNP cord-302514-rstvf3mc 229 93 analysis analysis NN cord-302514-rstvf3mc 229 94 unravels unravel VBZ cord-302514-rstvf3mc 229 95 the the DT cord-302514-rstvf3mc 229 96 functional functional JJ cord-302514-rstvf3mc 229 97 repertoire repertoire NN cord-302514-rstvf3mc 229 98 of of IN cord-302514-rstvf3mc 229 99 coronavirus coronavirus NN cord-302514-rstvf3mc 229 100 nonstructural nonstructural JJ cord-302514-rstvf3mc 229 101 protein protein NN cord-302514-rstvf3mc 229 102 3 3 CD cord-302514-rstvf3mc 229 103 Molecular Molecular NNP cord-302514-rstvf3mc 229 104 functions function NNS cord-302514-rstvf3mc 229 105 and and CC cord-302514-rstvf3mc 229 106 biological biological JJ cord-302514-rstvf3mc 229 107 roles role NNS cord-302514-rstvf3mc 229 108 of of IN cord-302514-rstvf3mc 229 109 hepatitis hepatitis NN cord-302514-rstvf3mc 229 110 B B NNP cord-302514-rstvf3mc 229 111 virus virus NN cord-302514-rstvf3mc 230 1 x x LS cord-302514-rstvf3mc 230 2 protein protein NN cord-302514-rstvf3mc 231 1 The the DT cord-302514-rstvf3mc 231 2 biological biological JJ cord-302514-rstvf3mc 231 3 properties property NNS cord-302514-rstvf3mc 231 4 of of IN cord-302514-rstvf3mc 231 5 E6 E6 NNP cord-302514-rstvf3mc 231 6 and and CC cord-302514-rstvf3mc 231 7 E7 E7 NNP cord-302514-rstvf3mc 231 8 oncoproteins oncoprotein NNS cord-302514-rstvf3mc 231 9 from from IN cord-302514-rstvf3mc 231 10 human human JJ cord-302514-rstvf3mc 231 11 papillomaviruses papillomaviruse NNS cord-302514-rstvf3mc 231 12 Proteomic Proteomic NNP cord-302514-rstvf3mc 231 13 and and CC cord-302514-rstvf3mc 231 14 biochemical biochemical JJ cord-302514-rstvf3mc 231 15 analysis analysis NN cord-302514-rstvf3mc 231 16 of of IN cord-302514-rstvf3mc 231 17 purified purify VBN cord-302514-rstvf3mc 231 18 human human JJ cord-302514-rstvf3mc 231 19 immunodeficiency immunodeficiency NN cord-302514-rstvf3mc 231 20 virus virus NN cord-302514-rstvf3mc 231 21 type type NN cord-302514-rstvf3mc 231 22 1 1 CD cord-302514-rstvf3mc 231 23 produced produce VBD cord-302514-rstvf3mc 231 24 from from IN cord-302514-rstvf3mc 231 25 infected infected JJ cord-302514-rstvf3mc 231 26 monocyte monocyte NNP cord-302514-rstvf3mc 231 27 - - HYPH cord-302514-rstvf3mc 231 28 derived derive VBN cord-302514-rstvf3mc 231 29 macrophages macrophage NNS cord-302514-rstvf3mc 231 30 The the DT cord-302514-rstvf3mc 231 31 authors author NNS cord-302514-rstvf3mc 231 32 declare declare VBP cord-302514-rstvf3mc 231 33 that that IN cord-302514-rstvf3mc 231 34 the the DT cord-302514-rstvf3mc 231 35 research research NN cord-302514-rstvf3mc 231 36 was be VBD cord-302514-rstvf3mc 231 37 conducted conduct VBN cord-302514-rstvf3mc 231 38 in in IN cord-302514-rstvf3mc 231 39 the the DT cord-302514-rstvf3mc 231 40 absence absence NN cord-302514-rstvf3mc 231 41 of of IN cord-302514-rstvf3mc 231 42 any any DT cord-302514-rstvf3mc 231 43 commercial commercial JJ cord-302514-rstvf3mc 231 44 or or CC cord-302514-rstvf3mc 231 45 financial financial JJ cord-302514-rstvf3mc 231 46 relationships relationship NNS cord-302514-rstvf3mc 231 47 that that WDT cord-302514-rstvf3mc 231 48 could could MD cord-302514-rstvf3mc 231 49 be be VB cord-302514-rstvf3mc 231 50 construed construe VBN cord-302514-rstvf3mc 231 51 as as IN cord-302514-rstvf3mc 231 52 a a DT cord-302514-rstvf3mc 231 53 potential potential JJ cord-302514-rstvf3mc 231 54 conflict conflict NN cord-302514-rstvf3mc 231 55 of of IN cord-302514-rstvf3mc 231 56 interest interest NN cord-302514-rstvf3mc 231 57 . . .