id	sid	tid	token	lemma	pos
cord-292688-w4zvfkyl	1	1	key	key	JJ
cord-292688-w4zvfkyl	1	2	:	:	:
cord-292688-w4zvfkyl	1	3	cord-292688-w4zvfkyl	cord-292688-w4zvfkyl	NN
cord-292688-w4zvfkyl	1	4	authors	author	NNS
cord-292688-w4zvfkyl	1	5	:	:	:
cord-292688-w4zvfkyl	1	6	Tooze	Tooze	NNP
cord-292688-w4zvfkyl	1	7	,	,	,
cord-292688-w4zvfkyl	1	8	Sharon	Sharon	NNP
cord-292688-w4zvfkyl	1	9	A	a	DT
cord-292688-w4zvfkyl	1	10	title	title	NN
cord-292688-w4zvfkyl	1	11	:	:	:
cord-292688-w4zvfkyl	1	12	Biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	1	13	of	of	IN
cord-292688-w4zvfkyl	1	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	1	15	granules	granule	NNS
cord-292688-w4zvfkyl	1	16	in	in	IN
cord-292688-w4zvfkyl	1	17	the	the	DT
cord-292688-w4zvfkyl	1	18	trans	trans	NNP
cord-292688-w4zvfkyl	1	19	-	-	NNP
cord-292688-w4zvfkyl	1	20	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	1	21	network	network	NN
cord-292688-w4zvfkyl	1	22	of	of	IN
cord-292688-w4zvfkyl	1	23	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	1	24	and	and	CC
cord-292688-w4zvfkyl	1	25	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	1	26	cells	cell	NNS
cord-292688-w4zvfkyl	1	27	date	date	NN
cord-292688-w4zvfkyl	1	28	:	:	:
cord-292688-w4zvfkyl	1	29	1998	1998	CD
cord-292688-w4zvfkyl	1	30	-	-	SYM
cord-292688-w4zvfkyl	1	31	08	08	CD
cord-292688-w4zvfkyl	1	32	-	-	SYM
cord-292688-w4zvfkyl	1	33	14	14	CD
cord-292688-w4zvfkyl	1	34	journal	journal	NN
cord-292688-w4zvfkyl	1	35	:	:	:
cord-292688-w4zvfkyl	2	1	Biochim	Biochim	NNP
cord-292688-w4zvfkyl	2	2	Biophys	Biophys	NNP
cord-292688-w4zvfkyl	2	3	Acta	Acta	NNP
cord-292688-w4zvfkyl	2	4	Mol	Mol	NNP
cord-292688-w4zvfkyl	2	5	Cell	cell	NN
cord-292688-w4zvfkyl	2	6	Res	res	NN
cord-292688-w4zvfkyl	2	7	DOI	doi	NN
cord-292688-w4zvfkyl	2	8	:	:	:
cord-292688-w4zvfkyl	3	1	10.1016	10.1016	CD
cord-292688-w4zvfkyl	3	2	/	/	SYM
cord-292688-w4zvfkyl	3	3	s0167	s0167	CD
cord-292688-w4zvfkyl	3	4	-	-	HYPH
cord-292688-w4zvfkyl	3	5	4889(98)00059	4889(98)00059	CD
cord-292688-w4zvfkyl	3	6	-	-	SYM
cord-292688-w4zvfkyl	3	7	7	7	CD
cord-292688-w4zvfkyl	3	8	sha	sha	NN
cord-292688-w4zvfkyl	3	9	:	:	:
cord-292688-w4zvfkyl	4	1	e257484bbae4ded770ffb80615524a722433fbd1	e257484bbae4ded770ffb80615524a722433fbd1	NNS
cord-292688-w4zvfkyl	5	1	doc_id	doc_id	CD
cord-292688-w4zvfkyl	5	2	:	:	:
cord-292688-w4zvfkyl	5	3	292688	292688	CD
cord-292688-w4zvfkyl	5	4	cord_uid	cord_uid	NNS
cord-292688-w4zvfkyl	5	5	:	:	:
cord-292688-w4zvfkyl	6	1	w4zvfkyl	w4zvfkyl	NNP
cord-292688-w4zvfkyl	6	2	Secretory	secretory	JJ
cord-292688-w4zvfkyl	6	3	granule	granule	NN
cord-292688-w4zvfkyl	6	4	formation	formation	NN
cord-292688-w4zvfkyl	6	5	requires	require	VBZ
cord-292688-w4zvfkyl	6	6	selection	selection	NN
cord-292688-w4zvfkyl	6	7	of	of	IN
cord-292688-w4zvfkyl	6	8	soluble	soluble	JJ
cord-292688-w4zvfkyl	6	9	and	and	CC
cord-292688-w4zvfkyl	6	10	membrane	membrane	NN
cord-292688-w4zvfkyl	6	11	proteins	protein	NNS
cord-292688-w4zvfkyl	6	12	into	into	IN
cord-292688-w4zvfkyl	6	13	nascent	nascent	JJ
cord-292688-w4zvfkyl	6	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	6	15	granules	granule	NNS
cord-292688-w4zvfkyl	6	16	,	,	,
cord-292688-w4zvfkyl	6	17	and	and	CC
cord-292688-w4zvfkyl	6	18	exclusion	exclusion	NN
cord-292688-w4zvfkyl	6	19	of	of	IN
cord-292688-w4zvfkyl	6	20	proteins	protein	NNS
cord-292688-w4zvfkyl	6	21	not	not	RB
cord-292688-w4zvfkyl	6	22	required	require	VBN
cord-292688-w4zvfkyl	6	23	for	for	IN
cord-292688-w4zvfkyl	6	24	the	the	DT
cord-292688-w4zvfkyl	6	25	function	function	NN
cord-292688-w4zvfkyl	6	26	of	of	IN
cord-292688-w4zvfkyl	6	27	secretory	secretory	JJ
cord-292688-w4zvfkyl	6	28	granules	granule	NNS
cord-292688-w4zvfkyl	6	29	.	.	.
cord-292688-w4zvfkyl	7	1	Both	both	DT
cord-292688-w4zvfkyl	7	2	selection	selection	NN
cord-292688-w4zvfkyl	7	3	and	and	CC
cord-292688-w4zvfkyl	7	4	exclusion	exclusion	NN
cord-292688-w4zvfkyl	7	5	presumably	presumably	RB
cord-292688-w4zvfkyl	7	6	can	can	MD
cord-292688-w4zvfkyl	7	7	occur	occur	VB
cord-292688-w4zvfkyl	7	8	in	in	IN
cord-292688-w4zvfkyl	7	9	the	the	DT
cord-292688-w4zvfkyl	7	10	compartment	compartment	NN
cord-292688-w4zvfkyl	7	11	where	where	WRB
cord-292688-w4zvfkyl	7	12	assembly	assembly	NN
cord-292688-w4zvfkyl	7	13	of	of	IN
cord-292688-w4zvfkyl	7	14	the	the	DT
cord-292688-w4zvfkyl	7	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	7	16	granule	granule	NN
cord-292688-w4zvfkyl	7	17	begins	begin	VBZ
cord-292688-w4zvfkyl	7	18	,	,	,
cord-292688-w4zvfkyl	7	19	the	the	DT
cord-292688-w4zvfkyl	7	20	trans	trans	NNP
cord-292688-w4zvfkyl	7	21	most	most	JJS
cord-292688-w4zvfkyl	7	22	cisternae	cisternae	NNP
cord-292688-w4zvfkyl	7	23	of	of	IN
cord-292688-w4zvfkyl	7	24	the	the	DT
cord-292688-w4zvfkyl	7	25	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	7	26	complex	complex	NN
cord-292688-w4zvfkyl	7	27	.	.	.
cord-292688-w4zvfkyl	8	1	Current	current	JJ
cord-292688-w4zvfkyl	8	2	research	research	NN
cord-292688-w4zvfkyl	8	3	focused	focus	VBD
cord-292688-w4zvfkyl	8	4	on	on	IN
cord-292688-w4zvfkyl	8	5	the	the	DT
cord-292688-w4zvfkyl	8	6	initial	initial	JJ
cord-292688-w4zvfkyl	8	7	stages	stage	NNS
cord-292688-w4zvfkyl	8	8	of	of	IN
cord-292688-w4zvfkyl	8	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	8	10	granule	granule	NN
cord-292688-w4zvfkyl	8	11	formation	formation	NN
cord-292688-w4zvfkyl	8	12	includes	include	VBZ
cord-292688-w4zvfkyl	8	13	a	a	DT
cord-292688-w4zvfkyl	8	14	search	search	NN
cord-292688-w4zvfkyl	8	15	for	for	IN
cord-292688-w4zvfkyl	8	16	the	the	DT
cord-292688-w4zvfkyl	8	17	‘	'	``
cord-292688-w4zvfkyl	8	18	signals	signal	NNS
cord-292688-w4zvfkyl	8	19	’	'	''
cord-292688-w4zvfkyl	8	20	which	which	WDT
cord-292688-w4zvfkyl	8	21	may	may	MD
cord-292688-w4zvfkyl	8	22	mediate	mediate	VB
cord-292688-w4zvfkyl	8	23	active	active	JJ
cord-292688-w4zvfkyl	8	24	sorting	sorting	NN
cord-292688-w4zvfkyl	8	25	of	of	IN
cord-292688-w4zvfkyl	8	26	components	component	NNS
cord-292688-w4zvfkyl	8	27	into	into	IN
cord-292688-w4zvfkyl	8	28	secretory	secretory	JJ
cord-292688-w4zvfkyl	8	29	granules	granule	NNS
cord-292688-w4zvfkyl	8	30	,	,	,
cord-292688-w4zvfkyl	8	31	and	and	CC
cord-292688-w4zvfkyl	8	32	the	the	DT
cord-292688-w4zvfkyl	8	33	role	role	NN
cord-292688-w4zvfkyl	8	34	of	of	IN
cord-292688-w4zvfkyl	8	35	aggregation	aggregation	NN
cord-292688-w4zvfkyl	8	36	of	of	IN
cord-292688-w4zvfkyl	8	37	regulated	regulate	VBN
cord-292688-w4zvfkyl	8	38	secretory	secretory	JJ
cord-292688-w4zvfkyl	8	39	proteins	protein	NNS
cord-292688-w4zvfkyl	8	40	in	in	IN
cord-292688-w4zvfkyl	8	41	sorting	sorting	NN
cord-292688-w4zvfkyl	8	42	.	.	.
cord-292688-w4zvfkyl	9	1	In	in	IN
cord-292688-w4zvfkyl	9	2	addition	addition	NN
cord-292688-w4zvfkyl	9	3	,	,	,
cord-292688-w4zvfkyl	9	4	the	the	DT
cord-292688-w4zvfkyl	9	5	temporal	temporal	JJ
cord-292688-w4zvfkyl	9	6	sequence	sequence	NN
cord-292688-w4zvfkyl	9	7	of	of	IN
cord-292688-w4zvfkyl	9	8	the	the	DT
cord-292688-w4zvfkyl	9	9	sorting	sorting	NN
cord-292688-w4zvfkyl	9	10	events	event	NNS
cord-292688-w4zvfkyl	9	11	in	in	IN
cord-292688-w4zvfkyl	9	12	the	the	DT
cord-292688-w4zvfkyl	9	13	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	9	14	,	,	,
cord-292688-w4zvfkyl	9	15	and	and	CC
cord-292688-w4zvfkyl	9	16	post	post	JJ
cord-292688-w4zvfkyl	9	17	-	-	JJ
cord-292688-w4zvfkyl	9	18	Golgi	golgi	JJ
cord-292688-w4zvfkyl	9	19	compartments	compartment	NNS
cord-292688-w4zvfkyl	9	20	has	have	VBZ
cord-292688-w4zvfkyl	9	21	gained	gain	VBN
cord-292688-w4zvfkyl	9	22	much	much	JJ
cord-292688-w4zvfkyl	9	23	attention	attention	NN
cord-292688-w4zvfkyl	9	24	,	,	,
cord-292688-w4zvfkyl	9	25	as	as	IN
cord-292688-w4zvfkyl	9	26	summarized	summarize	VBN
cord-292688-w4zvfkyl	9	27	by	by	IN
cord-292688-w4zvfkyl	9	28	the	the	DT
cord-292688-w4zvfkyl	9	29	alternative	alternative	NN
cord-292688-w4zvfkyl	9	30	but	but	CC
cord-292688-w4zvfkyl	9	31	not	not	RB
cord-292688-w4zvfkyl	9	32	mutually	mutually	RB
cord-292688-w4zvfkyl	9	33	exclusive	exclusive	JJ
cord-292688-w4zvfkyl	9	34	‘	'	``
cord-292688-w4zvfkyl	9	35	sorting	sorting	NN
cord-292688-w4zvfkyl	9	36	for	for	IN
cord-292688-w4zvfkyl	9	37	entry	entry	NN
cord-292688-w4zvfkyl	9	38	’	'	''
cord-292688-w4zvfkyl	9	39	vs.	vs.	CC
cord-292688-w4zvfkyl	9	40	‘	'	``
cord-292688-w4zvfkyl	9	41	sorting	sort	VBG
cord-292688-w4zvfkyl	9	42	by	by	IN
cord-292688-w4zvfkyl	9	43	retention	retention	NN
cord-292688-w4zvfkyl	9	44	’	'	''
cord-292688-w4zvfkyl	9	45	models	model	NNS
cord-292688-w4zvfkyl	9	46	.	.	.
cord-292688-w4zvfkyl	10	1	‘	'	``
cord-292688-w4zvfkyl	10	2	Sorting	sort	VBG
cord-292688-w4zvfkyl	10	3	for	for	IN
cord-292688-w4zvfkyl	10	4	entry	entry	NN
cord-292688-w4zvfkyl	10	5	’	'	''
cord-292688-w4zvfkyl	10	6	which	which	WDT
cord-292688-w4zvfkyl	10	7	encompasses	encompass	VBZ
cord-292688-w4zvfkyl	10	8	the	the	DT
cord-292688-w4zvfkyl	10	9	most	most	RBS
cord-292688-w4zvfkyl	10	10	popular	popular	JJ
cord-292688-w4zvfkyl	10	11	models	model	NNS
cord-292688-w4zvfkyl	10	12	requires	require	VBZ
cord-292688-w4zvfkyl	10	13	selection	selection	NN
cord-292688-w4zvfkyl	10	14	of	of	IN
cord-292688-w4zvfkyl	10	15	cargo	cargo	NN
cord-292688-w4zvfkyl	10	16	and	and	CC
cord-292688-w4zvfkyl	10	17	membrane	membrane	NN
cord-292688-w4zvfkyl	10	18	and	and	CC
cord-292688-w4zvfkyl	10	19	exclusion	exclusion	NN
cord-292688-w4zvfkyl	10	20	of	of	IN
cord-292688-w4zvfkyl	10	21	non	non	JJ
cord-292688-w4zvfkyl	10	22	-	-	JJ
cord-292688-w4zvfkyl	10	23	secretory	secretory	JJ
cord-292688-w4zvfkyl	10	24	granule	granule	NN
cord-292688-w4zvfkyl	10	25	proteins	protein	NNS
cord-292688-w4zvfkyl	10	26	in	in	IN
cord-292688-w4zvfkyl	10	27	the	the	DT
cord-292688-w4zvfkyl	10	28	TGN	TGN	NNP
cord-292688-w4zvfkyl	10	29	prior	prior	RB
cord-292688-w4zvfkyl	10	30	to	to	IN
cord-292688-w4zvfkyl	10	31	secretory	secretory	JJ
cord-292688-w4zvfkyl	10	32	granule	granule	NN
cord-292688-w4zvfkyl	10	33	formation	formation	NN
cord-292688-w4zvfkyl	10	34	.	.	.
cord-292688-w4zvfkyl	11	1	‘	'	``
cord-292688-w4zvfkyl	11	2	Sorting	sort	VBG
cord-292688-w4zvfkyl	11	3	by	by	IN
cord-292688-w4zvfkyl	11	4	retention	retention	NN
cord-292688-w4zvfkyl	11	5	’	'	''
cord-292688-w4zvfkyl	11	6	stipulates	stipulate	VBZ
cord-292688-w4zvfkyl	11	7	that	that	IN
cord-292688-w4zvfkyl	11	8	protein	protein	NN
cord-292688-w4zvfkyl	11	9	selection	selection	NN
cord-292688-w4zvfkyl	11	10	or	or	CC
cord-292688-w4zvfkyl	11	11	exclusion	exclusion	NN
cord-292688-w4zvfkyl	11	12	may	may	MD
cord-292688-w4zvfkyl	11	13	occur	occur	VB
cord-292688-w4zvfkyl	11	14	after	after	IN
cord-292688-w4zvfkyl	11	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	11	16	granule	granule	NN
cord-292688-w4zvfkyl	11	17	formation	formation	NN
cord-292688-w4zvfkyl	11	18	:	:	:
cord-292688-w4zvfkyl	11	19	secretory	secretory	JJ
cord-292688-w4zvfkyl	11	20	granule	granule	NN
cord-292688-w4zvfkyl	11	21	specific	specific	JJ
cord-292688-w4zvfkyl	11	22	components	component	NNS
cord-292688-w4zvfkyl	11	23	are	be	VBP
cord-292688-w4zvfkyl	11	24	retained	retain	VBN
cord-292688-w4zvfkyl	11	25	during	during	IN
cord-292688-w4zvfkyl	11	26	maturation	maturation	NN
cord-292688-w4zvfkyl	11	27	of	of	IN
cord-292688-w4zvfkyl	11	28	the	the	DT
cord-292688-w4zvfkyl	11	29	granule	granule	NN
cord-292688-w4zvfkyl	11	30	while	while	IN
cord-292688-w4zvfkyl	11	31	non	non	JJ
cord-292688-w4zvfkyl	11	32	-	-	JJ
cord-292688-w4zvfkyl	11	33	secretory	secretory	JJ
cord-292688-w4zvfkyl	11	34	granule	granule	NN
cord-292688-w4zvfkyl	11	35	molecules	molecule	NNS
cord-292688-w4zvfkyl	11	36	are	be	VBP
cord-292688-w4zvfkyl	11	37	removed	remove	VBN
cord-292688-w4zvfkyl	11	38	in	in	IN
cord-292688-w4zvfkyl	11	39	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	11	40	which	which	WDT
cord-292688-w4zvfkyl	11	41	bud	bud	VBP
cord-292688-w4zvfkyl	11	42	from	from	IN
cord-292688-w4zvfkyl	11	43	maturing	mature	VBG
cord-292688-w4zvfkyl	11	44	secretory	secretory	JJ
cord-292688-w4zvfkyl	11	45	granules	granule	NNS
cord-292688-w4zvfkyl	11	46	.	.	.
cord-292688-w4zvfkyl	12	1	Finally	finally	RB
cord-292688-w4zvfkyl	12	2	,	,	,
cord-292688-w4zvfkyl	12	3	some	some	DT
cord-292688-w4zvfkyl	12	4	progress	progress	NN
cord-292688-w4zvfkyl	12	5	has	have	VBZ
cord-292688-w4zvfkyl	12	6	been	be	VBN
cord-292688-w4zvfkyl	12	7	made	make	VBN
cord-292688-w4zvfkyl	12	8	in	in	IN
cord-292688-w4zvfkyl	12	9	the	the	DT
cord-292688-w4zvfkyl	12	10	identification	identification	NN
cord-292688-w4zvfkyl	12	11	of	of	IN
cord-292688-w4zvfkyl	12	12	cytosolic	cytosolic	JJ
cord-292688-w4zvfkyl	12	13	components	component	NNS
cord-292688-w4zvfkyl	12	14	involved	involve	VBN
cord-292688-w4zvfkyl	12	15	in	in	IN
cord-292688-w4zvfkyl	12	16	the	the	DT
cord-292688-w4zvfkyl	12	17	budding	budding	NN
cord-292688-w4zvfkyl	12	18	of	of	IN
cord-292688-w4zvfkyl	12	19	nascent	nascent	JJ
cord-292688-w4zvfkyl	12	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	12	21	granules	granule	NNS
cord-292688-w4zvfkyl	12	22	from	from	IN
cord-292688-w4zvfkyl	12	23	the	the	DT
cord-292688-w4zvfkyl	12	24	TGN	TGN	NNP
cord-292688-w4zvfkyl	12	25	.	.	.
cord-292688-w4zvfkyl	13	1	This	this	DT
cord-292688-w4zvfkyl	13	2	review	review	NN
cord-292688-w4zvfkyl	13	3	will	will	MD
cord-292688-w4zvfkyl	13	4	focus	focus	VB
cord-292688-w4zvfkyl	13	5	on	on	IN
cord-292688-w4zvfkyl	13	6	the	the	DT
cord-292688-w4zvfkyl	13	7	recent	recent	JJ
cord-292688-w4zvfkyl	13	8	data	datum	NNS
cord-292688-w4zvfkyl	13	9	concerning	concern	VBG
cord-292688-w4zvfkyl	13	10	the	the	DT
cord-292688-w4zvfkyl	13	11	events	event	NNS
cord-292688-w4zvfkyl	13	12	in	in	IN
cord-292688-w4zvfkyl	13	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	13	14	granule	granule	NN
cord-292688-w4zvfkyl	13	15	formation	formation	NN
cord-292688-w4zvfkyl	13	16	which	which	WDT
cord-292688-w4zvfkyl	13	17	occur	occur	VBP
cord-292688-w4zvfkyl	13	18	,	,	,
cord-292688-w4zvfkyl	13	19	in	in	IN
cord-292688-w4zvfkyl	13	20	the	the	DT
cord-292688-w4zvfkyl	13	21	trans	trans	NNP
cord-292688-w4zvfkyl	13	22	-	-	NNP
cord-292688-w4zvfkyl	13	23	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	13	24	network	network	NN
cord-292688-w4zvfkyl	13	25	.	.	.
cord-292688-w4zvfkyl	14	1	Dense	dense	JJ
cord-292688-w4zvfkyl	14	2	core	core	NN
cord-292688-w4zvfkyl	14	3	secretory	secretory	NN
cord-292688-w4zvfkyl	14	4	granules	granule	NNS
cord-292688-w4zvfkyl	14	5	are	be	VBP
cord-292688-w4zvfkyl	14	6	found	find	VBN
cord-292688-w4zvfkyl	14	7	in	in	IN
cord-292688-w4zvfkyl	14	8	all	all	DT
cord-292688-w4zvfkyl	14	9	exocrine	exocrine	JJ
cord-292688-w4zvfkyl	14	10	,	,	,
cord-292688-w4zvfkyl	14	11	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	14	12	,	,	,
cord-292688-w4zvfkyl	14	13	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	14	14	,	,	,
cord-292688-w4zvfkyl	14	15	and	and	CC
cord-292688-w4zvfkyl	14	16	neuronal	neuronal	JJ
cord-292688-w4zvfkyl	14	17	cells	cell	NNS
cord-292688-w4zvfkyl	14	18	.	.	.
cord-292688-w4zvfkyl	15	1	Vesicles	Vesicles	NNP
cord-292688-w4zvfkyl	15	2	which	which	WDT
cord-292688-w4zvfkyl	15	3	are	be	VBP
cord-292688-w4zvfkyl	15	4	similar	similar	JJ
cord-292688-w4zvfkyl	15	5	to	to	IN
cord-292688-w4zvfkyl	15	6	secretory	secretory	JJ
cord-292688-w4zvfkyl	15	7	granules	granule	NNS
cord-292688-w4zvfkyl	15	8	are	be	VBP
cord-292688-w4zvfkyl	15	9	also	also	RB
cord-292688-w4zvfkyl	15	10	found	find	VBN
cord-292688-w4zvfkyl	15	11	in	in	IN
cord-292688-w4zvfkyl	15	12	cells	cell	NNS
cord-292688-w4zvfkyl	15	13	of	of	IN
cord-292688-w4zvfkyl	15	14	the	the	DT
cord-292688-w4zvfkyl	15	15	haemopoetic	haemopoetic	JJ
cord-292688-w4zvfkyl	15	16	and	and	CC
cord-292688-w4zvfkyl	15	17	immune	immune	JJ
cord-292688-w4zvfkyl	15	18	systems	system	NNS
cord-292688-w4zvfkyl	15	19	.	.	.
cord-292688-w4zvfkyl	16	1	Formation	formation	NN
cord-292688-w4zvfkyl	16	2	of	of	IN
cord-292688-w4zvfkyl	16	3	these	these	DT
cord-292688-w4zvfkyl	16	4	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	16	5	is	be	VBZ
cord-292688-w4zvfkyl	16	6	initiated	initiate	VBN
cord-292688-w4zvfkyl	16	7	in	in	IN
cord-292688-w4zvfkyl	16	8	the	the	DT
cord-292688-w4zvfkyl	16	9	trans	trans	NNP
cord-292688-w4zvfkyl	16	10	-	-	NNP
cord-292688-w4zvfkyl	16	11	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	16	12	network	network	NN
cord-292688-w4zvfkyl	16	13	(	(	-LRB-
cord-292688-w4zvfkyl	16	14	TGN	TGN	NNP
cord-292688-w4zvfkyl	16	15	)	)	-RRB-
cord-292688-w4zvfkyl	16	16	and	and	CC
cord-292688-w4zvfkyl	16	17	results	result	NNS
cord-292688-w4zvfkyl	16	18	in	in	IN
cord-292688-w4zvfkyl	16	19	the	the	DT
cord-292688-w4zvfkyl	16	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	16	21	proteins	protein	NNS
cord-292688-w4zvfkyl	16	22	being	be	VBG
cord-292688-w4zvfkyl	16	23	packaged	package	VBN
cord-292688-w4zvfkyl	16	24	in	in	IN
cord-292688-w4zvfkyl	16	25	a	a	DT
cord-292688-w4zvfkyl	16	26	concentrated	concentrated	JJ
cord-292688-w4zvfkyl	16	27	form	form	NN
cord-292688-w4zvfkyl	16	28	in	in	IN
cord-292688-w4zvfkyl	16	29	the	the	DT
cord-292688-w4zvfkyl	16	30	secretory	secretory	JJ
cord-292688-w4zvfkyl	16	31	granules	granule	NNS
cord-292688-w4zvfkyl	16	32	.	.	.
cord-292688-w4zvfkyl	17	1	Unstimulated	unstimulated	JJ
cord-292688-w4zvfkyl	17	2	exocytosis	exocytosis	NN
cord-292688-w4zvfkyl	17	3	of	of	IN
cord-292688-w4zvfkyl	17	4	these	these	DT
cord-292688-w4zvfkyl	17	5	granules	granule	NNS
cord-292688-w4zvfkyl	17	6	occurs	occur	VBZ
cord-292688-w4zvfkyl	17	7	at	at	IN
cord-292688-w4zvfkyl	17	8	low	low	JJ
cord-292688-w4zvfkyl	17	9	levels	level	NNS
cord-292688-w4zvfkyl	17	10	,	,	,
cord-292688-w4zvfkyl	17	11	but	but	CC
cord-292688-w4zvfkyl	17	12	ampli¢ed	ampli¢ed	CD
cord-292688-w4zvfkyl	17	13	secretion	secretion	NN
cord-292688-w4zvfkyl	17	14	from	from	IN
cord-292688-w4zvfkyl	17	15	the	the	DT
cord-292688-w4zvfkyl	17	16	cell	cell	NN
cord-292688-w4zvfkyl	17	17	of	of	IN
cord-292688-w4zvfkyl	17	18	proteins	protein	NNS
cord-292688-w4zvfkyl	17	19	within	within	IN
cord-292688-w4zvfkyl	17	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	17	21	granules	granule	NNS
cord-292688-w4zvfkyl	17	22	is	be	VBZ
cord-292688-w4zvfkyl	17	23	regulated	regulate	VBN
cord-292688-w4zvfkyl	17	24	exclusively	exclusively	RB
cord-292688-w4zvfkyl	17	25	via	via	IN
cord-292688-w4zvfkyl	17	26	external	external	JJ
cord-292688-w4zvfkyl	17	27	stimuli	stimulus	NNS
cord-292688-w4zvfkyl	17	28	which	which	WDT
cord-292688-w4zvfkyl	17	29	triggers	trigger	VBZ
cord-292688-w4zvfkyl	17	30	the	the	DT
cord-292688-w4zvfkyl	17	31	fusion	fusion	NN
cord-292688-w4zvfkyl	17	32	of	of	IN
cord-292688-w4zvfkyl	17	33	the	the	DT
cord-292688-w4zvfkyl	17	34	secretory	secretory	JJ
cord-292688-w4zvfkyl	17	35	granule	granule	NN
cord-292688-w4zvfkyl	17	36	membrane	membrane	NN
cord-292688-w4zvfkyl	17	37	with	with	IN
cord-292688-w4zvfkyl	17	38	the	the	DT
cord-292688-w4zvfkyl	17	39	plasma	plasma	NN
cord-292688-w4zvfkyl	17	40	membrane	membrane	NN
cord-292688-w4zvfkyl	17	41	.	.	.
cord-292688-w4zvfkyl	18	1	Secretory	secretory	JJ
cord-292688-w4zvfkyl	18	2	granules	granule	NNS
cord-292688-w4zvfkyl	18	3	in	in	IN
cord-292688-w4zvfkyl	18	4	endocrine	endocrine	NN
cord-292688-w4zvfkyl	18	5	and	and	CC
cord-292688-w4zvfkyl	18	6	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	18	7	cells	cell	NNS
cord-292688-w4zvfkyl	18	8	have	have	VBP
cord-292688-w4zvfkyl	18	9	a	a	DT
cord-292688-w4zvfkyl	18	10	very	very	RB
cord-292688-w4zvfkyl	18	11	similar	similar	JJ
cord-292688-w4zvfkyl	18	12	composition	composition	NN
cord-292688-w4zvfkyl	18	13	.	.	.
cord-292688-w4zvfkyl	19	1	The	the	DT
cord-292688-w4zvfkyl	19	2	limiting	limit	VBG
cord-292688-w4zvfkyl	19	3	membrane	membrane	NN
cord-292688-w4zvfkyl	19	4	contains	contain	VBZ
cord-292688-w4zvfkyl	19	5	proteins	protein	NNS
cord-292688-w4zvfkyl	19	6	required	require	VBN
cord-292688-w4zvfkyl	19	7	for	for	IN
cord-292688-w4zvfkyl	19	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	19	9	granule	granule	NN
cord-292688-w4zvfkyl	19	10	acidi¢cation	acidi¢cation	NN
cord-292688-w4zvfkyl	19	11	,	,	,
cord-292688-w4zvfkyl	19	12	transport	transport	NN
cord-292688-w4zvfkyl	19	13	,	,	,
cord-292688-w4zvfkyl	19	14	targeting	targeting	NN
cord-292688-w4zvfkyl	19	15	and	and	CC
cord-292688-w4zvfkyl	19	16	fusion	fusion	NN
cord-292688-w4zvfkyl	19	17	,	,	,
cord-292688-w4zvfkyl	19	18	while	while	IN
cord-292688-w4zvfkyl	19	19	the	the	DT
cord-292688-w4zvfkyl	19	20	dense	dense	JJ
cord-292688-w4zvfkyl	19	21	core	core	NN
cord-292688-w4zvfkyl	19	22	content	content	NN
cord-292688-w4zvfkyl	19	23	is	be	VBZ
cord-292688-w4zvfkyl	19	24	composed	compose	VBN
cord-292688-w4zvfkyl	19	25	of	of	IN
cord-292688-w4zvfkyl	19	26	a	a	DT
cord-292688-w4zvfkyl	19	27	set	set	NN
cord-292688-w4zvfkyl	19	28	of	of	IN
cord-292688-w4zvfkyl	19	29	soluble	soluble	JJ
cord-292688-w4zvfkyl	19	30	proteins	protein	NNS
cord-292688-w4zvfkyl	19	31	,	,	,
cord-292688-w4zvfkyl	19	32	some	some	DT
cord-292688-w4zvfkyl	19	33	of	of	IN
cord-292688-w4zvfkyl	19	34	which	which	WDT
cord-292688-w4zvfkyl	19	35	are	be	VBP
cord-292688-w4zvfkyl	19	36	substrates	substrate	NNS
cord-292688-w4zvfkyl	19	37	,	,	,
cord-292688-w4zvfkyl	19	38	some	some	DT
cord-292688-w4zvfkyl	19	39	of	of	IN
cord-292688-w4zvfkyl	19	40	which	which	WDT
cord-292688-w4zvfkyl	19	41	are	be	VBP
cord-292688-w4zvfkyl	19	42	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	19	43	,	,	,
cord-292688-w4zvfkyl	19	44	others	other	NNS
cord-292688-w4zvfkyl	19	45	of	of	IN
cord-292688-w4zvfkyl	19	46	which	which	WDT
cord-292688-w4zvfkyl	19	47	have	have	VBP
cord-292688-w4zvfkyl	19	48	an	an	DT
cord-292688-w4zvfkyl	19	49	as	as	RB
cord-292688-w4zvfkyl	19	50	yet	yet	RB
cord-292688-w4zvfkyl	19	51	unidenti¢ed	unidenti¢ed	CD
cord-292688-w4zvfkyl	19	52	function	function	NN
cord-292688-w4zvfkyl	19	53	.	.	.
cord-292688-w4zvfkyl	20	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	20	2	is	be	VBZ
cord-292688-w4zvfkyl	20	3	known	know	VBN
cord-292688-w4zvfkyl	20	4	that	that	IN
cord-292688-w4zvfkyl	20	5	there	there	EX
cord-292688-w4zvfkyl	20	6	is	be	VBZ
cord-292688-w4zvfkyl	20	7	variation	variation	NN
cord-292688-w4zvfkyl	20	8	in	in	IN
cord-292688-w4zvfkyl	20	9	the	the	DT
cord-292688-w4zvfkyl	20	10	content	content	NN
cord-292688-w4zvfkyl	20	11	of	of	IN
cord-292688-w4zvfkyl	20	12	the	the	DT
cord-292688-w4zvfkyl	20	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	20	14	granule	granule	NN
cord-292688-w4zvfkyl	20	15	,	,	,
cord-292688-w4zvfkyl	20	16	depending	depend	VBG
cord-292688-w4zvfkyl	20	17	on	on	IN
cord-292688-w4zvfkyl	20	18	the	the	DT
cord-292688-w4zvfkyl	20	19	type	type	NN
cord-292688-w4zvfkyl	20	20	of	of	IN
cord-292688-w4zvfkyl	20	21	tissue	tissue	NN
cord-292688-w4zvfkyl	20	22	the	the	DT
cord-292688-w4zvfkyl	20	23	cell	cell	NN
cord-292688-w4zvfkyl	20	24	is	be	VBZ
cord-292688-w4zvfkyl	20	25	derived	derive	VBN
cord-292688-w4zvfkyl	20	26	from	from	IN
cord-292688-w4zvfkyl	20	27	,	,	,
cord-292688-w4zvfkyl	20	28	however	however	RB
cord-292688-w4zvfkyl	20	29	,	,	,
cord-292688-w4zvfkyl	20	30	very	very	RB
cord-292688-w4zvfkyl	20	31	little	little	JJ
cord-292688-w4zvfkyl	20	32	is	be	VBZ
cord-292688-w4zvfkyl	20	33	known	know	VBN
cord-292688-w4zvfkyl	20	34	about	about	IN
cord-292688-w4zvfkyl	20	35	the	the	DT
cord-292688-w4zvfkyl	20	36	membrane	membrane	NN
cord-292688-w4zvfkyl	20	37	composition	composition	NN
cord-292688-w4zvfkyl	20	38	and	and	CC
cord-292688-w4zvfkyl	20	39	the	the	DT
cord-292688-w4zvfkyl	20	40	variation	variation	NN
cord-292688-w4zvfkyl	20	41	which	which	WDT
cord-292688-w4zvfkyl	20	42	might	may	MD
cord-292688-w4zvfkyl	20	43	be	be	VB
cord-292688-w4zvfkyl	20	44	present	present	JJ
cord-292688-w4zvfkyl	20	45	in	in	IN
cord-292688-w4zvfkyl	20	46	the	the	DT
cord-292688-w4zvfkyl	20	47	molecules	molecule	NNS
cord-292688-w4zvfkyl	20	48	involved	involve	VBN
cord-292688-w4zvfkyl	20	49	in	in	IN
cord-292688-w4zvfkyl	20	50	secretory	secretory	JJ
cord-292688-w4zvfkyl	20	51	granule	granule	NN
cord-292688-w4zvfkyl	20	52	biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	20	53	,	,	,
cord-292688-w4zvfkyl	20	54	targeting	targeting	NN
cord-292688-w4zvfkyl	20	55	and	and	CC
cord-292688-w4zvfkyl	20	56	fusion	fusion	NN
cord-292688-w4zvfkyl	20	57	.	.	.
cord-292688-w4zvfkyl	21	1	Research	research	NN
cord-292688-w4zvfkyl	21	2	into	into	IN
cord-292688-w4zvfkyl	21	3	the	the	DT
cord-292688-w4zvfkyl	21	4	formation	formation	NN
cord-292688-w4zvfkyl	21	5	of	of	IN
cord-292688-w4zvfkyl	21	6	the	the	DT
cord-292688-w4zvfkyl	21	7	secretory	secretory	JJ
cord-292688-w4zvfkyl	21	8	granules	granule	NNS
cord-292688-w4zvfkyl	21	9	from	from	IN
cord-292688-w4zvfkyl	21	10	the	the	DT
cord-292688-w4zvfkyl	21	11	TGN	TGN	NNP
cord-292688-w4zvfkyl	21	12	is	be	VBZ
cord-292688-w4zvfkyl	21	13	mainly	mainly	RB
cord-292688-w4zvfkyl	21	14	concerned	concern	VBN
cord-292688-w4zvfkyl	21	15	with	with	IN
cord-292688-w4zvfkyl	21	16	how	how	WRB
cord-292688-w4zvfkyl	21	17	the	the	DT
cord-292688-w4zvfkyl	21	18	soluble	soluble	JJ
cord-292688-w4zvfkyl	21	19	regulated	regulate	VBN
cord-292688-w4zvfkyl	21	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	21	21	proteins	protein	NNS
cord-292688-w4zvfkyl	21	22	are	be	VBP
cord-292688-w4zvfkyl	21	23	targeted	target	VBN
cord-292688-w4zvfkyl	21	24	into	into	IN
cord-292688-w4zvfkyl	21	25	the	the	DT
cord-292688-w4zvfkyl	21	26	secretory	secretory	JJ
cord-292688-w4zvfkyl	21	27	granule	granule	NN
cord-292688-w4zvfkyl	21	28	,	,	,
cord-292688-w4zvfkyl	21	29	how	how	WRB
cord-292688-w4zvfkyl	21	30	soluble	soluble	JJ
cord-292688-w4zvfkyl	21	31	non	non	JJ
cord-292688-w4zvfkyl	21	32	-	-	JJ
cord-292688-w4zvfkyl	21	33	secretory	secretory	JJ
cord-292688-w4zvfkyl	21	34	granule	granule	NN
cord-292688-w4zvfkyl	21	35	proteins	protein	NNS
cord-292688-w4zvfkyl	21	36	are	be	VBP
cord-292688-w4zvfkyl	21	37	excluded	exclude	VBN
cord-292688-w4zvfkyl	21	38	,	,	,
cord-292688-w4zvfkyl	21	39	if	if	IN
cord-292688-w4zvfkyl	21	40	at	at	RB
cord-292688-w4zvfkyl	21	41	all	all	RB
cord-292688-w4zvfkyl	21	42	,	,	,
cord-292688-w4zvfkyl	21	43	what	what	WDT
cord-292688-w4zvfkyl	21	44	factors	factor	NNS
cord-292688-w4zvfkyl	21	45	determine	determine	VBP
cord-292688-w4zvfkyl	21	46	the	the	DT
cord-292688-w4zvfkyl	21	47	membrane	membrane	NN
cord-292688-w4zvfkyl	21	48	composition	composition	NN
cord-292688-w4zvfkyl	21	49	,	,	,
cord-292688-w4zvfkyl	21	50	and	and	CC
cord-292688-w4zvfkyl	21	51	how	how	WRB
cord-292688-w4zvfkyl	21	52	secretory	secretory	JJ
cord-292688-w4zvfkyl	21	53	granule	granule	NN
cord-292688-w4zvfkyl	21	54	budding	budding	NN
cord-292688-w4zvfkyl	21	55	occurs	occur	VBZ
cord-292688-w4zvfkyl	21	56	from	from	IN
cord-292688-w4zvfkyl	21	57	the	the	DT
cord-292688-w4zvfkyl	21	58	TGN	TGN	NNP
cord-292688-w4zvfkyl	21	59	.	.	.
cord-292688-w4zvfkyl	22	1	This	this	DT
cord-292688-w4zvfkyl	22	2	research	research	NN
cord-292688-w4zvfkyl	22	3	is	be	VBZ
cord-292688-w4zvfkyl	22	4	complicated	complicate	VBN
cord-292688-w4zvfkyl	22	5	by	by	IN
cord-292688-w4zvfkyl	22	6	the	the	DT
cord-292688-w4zvfkyl	22	7	fact	fact	NN
cord-292688-w4zvfkyl	22	8	that	that	IN
cord-292688-w4zvfkyl	22	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	22	10	granule	granule	NN
cord-292688-w4zvfkyl	22	11	formation	formation	NN
cord-292688-w4zvfkyl	22	12	could	could	MD
cord-292688-w4zvfkyl	22	13	occur	occur	VB
cord-292688-w4zvfkyl	22	14	in	in	IN
cord-292688-w4zvfkyl	22	15	parallel	parallel	NN
cord-292688-w4zvfkyl	22	16	with	with	IN
cord-292688-w4zvfkyl	22	17	formation	formation	NN
cord-292688-w4zvfkyl	22	18	of	of	IN
cord-292688-w4zvfkyl	22	19	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	22	20	directed	direct	VBN
cord-292688-w4zvfkyl	22	21	to	to	IN
cord-292688-w4zvfkyl	22	22	endosomes	endosome	NNS
cord-292688-w4zvfkyl	22	23	or	or	CC
cord-292688-w4zvfkyl	22	24	the	the	DT
cord-292688-w4zvfkyl	22	25	plasma	plasma	NN
cord-292688-w4zvfkyl	22	26	membrane	membrane	NN
cord-292688-w4zvfkyl	22	27	.	.	.
cord-292688-w4zvfkyl	23	1	This	this	DT
cord-292688-w4zvfkyl	23	2	review	review	NN
cord-292688-w4zvfkyl	23	3	will	will	MD
cord-292688-w4zvfkyl	23	4	explore	explore	VB
cord-292688-w4zvfkyl	23	5	the	the	DT
cord-292688-w4zvfkyl	23	6	recent	recent	JJ
cord-292688-w4zvfkyl	23	7	progress	progress	NN
cord-292688-w4zvfkyl	23	8	in	in	IN
cord-292688-w4zvfkyl	23	9	these	these	DT
cord-292688-w4zvfkyl	23	10	areas	area	NNS
cord-292688-w4zvfkyl	23	11	and	and	CC
cord-292688-w4zvfkyl	23	12	attempt	attempt	VB
cord-292688-w4zvfkyl	23	13	to	to	TO
cord-292688-w4zvfkyl	23	14	compare	compare	VB
cord-292688-w4zvfkyl	23	15	the	the	DT
cord-292688-w4zvfkyl	23	16	current	current	JJ
cord-292688-w4zvfkyl	23	17	models	model	NNS
cord-292688-w4zvfkyl	23	18	of	of	IN
cord-292688-w4zvfkyl	23	19	secretory	secretory	JJ
cord-292688-w4zvfkyl	23	20	granule	granule	NN
cord-292688-w4zvfkyl	23	21	biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	23	22	from	from	IN
cord-292688-w4zvfkyl	23	23	the	the	DT
cord-292688-w4zvfkyl	23	24	TGN	TGN	NNP
cord-292688-w4zvfkyl	23	25	in	in	IN
cord-292688-w4zvfkyl	23	26	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	23	27	cells	cell	NNS
cord-292688-w4zvfkyl	23	28	and	and	CC
cord-292688-w4zvfkyl	23	29	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	23	30	cells	cell	NNS
cord-292688-w4zvfkyl	23	31	.	.	.
cord-292688-w4zvfkyl	24	1	Regulated	regulated	JJ
cord-292688-w4zvfkyl	24	2	secretory	secretory	JJ
cord-292688-w4zvfkyl	24	3	proteins	protein	NNS
cord-292688-w4zvfkyl	24	4	are	be	VBP
cord-292688-w4zvfkyl	24	5	packaged	package	VBN
cord-292688-w4zvfkyl	24	6	into	into	IN
cord-292688-w4zvfkyl	24	7	nascent	nascent	JJ
cord-292688-w4zvfkyl	24	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	24	9	granules	granule	NNS
cord-292688-w4zvfkyl	24	10	(	(	-LRB-
cord-292688-w4zvfkyl	24	11	which	which	WDT
cord-292688-w4zvfkyl	24	12	are	be	VBP
cord-292688-w4zvfkyl	24	13	referred	refer	VBN
cord-292688-w4zvfkyl	24	14	to	to	IN
cord-292688-w4zvfkyl	24	15	as	as	RB
cord-292688-w4zvfkyl	24	16	immature	immature	JJ
cord-292688-w4zvfkyl	24	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	24	18	granules	granule	NNS
cord-292688-w4zvfkyl	24	19	(	(	-LRB-
cord-292688-w4zvfkyl	24	20	ISGs	ISGs	NNP
cord-292688-w4zvfkyl	24	21	)	)	-RRB-
cord-292688-w4zvfkyl	24	22	)	)	-RRB-
cord-292688-w4zvfkyl	24	23	in	in	IN
cord-292688-w4zvfkyl	24	24	a	a	DT
cord-292688-w4zvfkyl	24	25	process	process	NN
cord-292688-w4zvfkyl	24	26	that	that	WDT
cord-292688-w4zvfkyl	24	27	is	be	VBZ
cord-292688-w4zvfkyl	24	28	thought	think	VBN
cord-292688-w4zvfkyl	24	29	to	to	TO
cord-292688-w4zvfkyl	24	30	be	be	VB
cord-292688-w4zvfkyl	24	31	initiated	initiate	VBN
cord-292688-w4zvfkyl	24	32	by	by	IN
cord-292688-w4zvfkyl	24	33	selective	selective	JJ
cord-292688-w4zvfkyl	24	34	aggregation	aggregation	NN
cord-292688-w4zvfkyl	24	35	of	of	IN
cord-292688-w4zvfkyl	24	36	the	the	DT
cord-292688-w4zvfkyl	24	37	secretory	secretory	JJ
cord-292688-w4zvfkyl	24	38	proteins	protein	NNS
cord-292688-w4zvfkyl	24	39	in	in	IN
cord-292688-w4zvfkyl	24	40	the	the	DT
cord-292688-w4zvfkyl	24	41	TGN	TGN	NNP
cord-292688-w4zvfkyl	24	42	,	,	,
cord-292688-w4zvfkyl	24	43	followed	follow	VBN
cord-292688-w4zvfkyl	24	44	by	by	IN
cord-292688-w4zvfkyl	24	45	interaction	interaction	NN
cord-292688-w4zvfkyl	24	46	of	of	IN
cord-292688-w4zvfkyl	24	47	the	the	DT
cord-292688-w4zvfkyl	24	48	aggregate	aggregate	NN
cord-292688-w4zvfkyl	24	49	with	with	IN
cord-292688-w4zvfkyl	24	50	the	the	DT
cord-292688-w4zvfkyl	24	51	TGN	TGN	NNP
cord-292688-w4zvfkyl	24	52	membrane	membrane	NN
cord-292688-w4zvfkyl	24	53	which	which	WDT
cord-292688-w4zvfkyl	24	54	may	may	MD
cord-292688-w4zvfkyl	24	55	involve	involve	VB
cord-292688-w4zvfkyl	24	56	receptor	receptor	NN
cord-292688-w4zvfkyl	24	57	molecules	molecule	NNS
cord-292688-w4zvfkyl	24	58	.	.	.
cord-292688-w4zvfkyl	25	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	25	2	is	be	VBZ
cord-292688-w4zvfkyl	25	3	also	also	RB
cord-292688-w4zvfkyl	25	4	possible	possible	JJ
cord-292688-w4zvfkyl	25	5	that	that	IN
cord-292688-w4zvfkyl	25	6	selection	selection	NN
cord-292688-w4zvfkyl	25	7	may	may	MD
cord-292688-w4zvfkyl	25	8	be	be	VB
cord-292688-w4zvfkyl	25	9	achieved	achieve	VBN
cord-292688-w4zvfkyl	25	10	by	by	IN
cord-292688-w4zvfkyl	25	11	interaction	interaction	NN
cord-292688-w4zvfkyl	25	12	of	of	IN
cord-292688-w4zvfkyl	25	13	individual	individual	JJ
cord-292688-w4zvfkyl	25	14	regulated	regulated	JJ
cord-292688-w4zvfkyl	25	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	25	16	proteins	protein	NNS
cord-292688-w4zvfkyl	25	17	with	with	IN
cord-292688-w4zvfkyl	25	18	a	a	DT
cord-292688-w4zvfkyl	25	19	putative	putative	JJ
cord-292688-w4zvfkyl	25	20	membrane	membrane	NN
cord-292688-w4zvfkyl	25	21	receptor	receptor	NN
cord-292688-w4zvfkyl	25	22	prior	prior	RB
cord-292688-w4zvfkyl	25	23	to	to	IN
cord-292688-w4zvfkyl	25	24	aggregation	aggregation	NN
cord-292688-w4zvfkyl	25	25	.	.	.
cord-292688-w4zvfkyl	26	1	Proteins	protein	NNS
cord-292688-w4zvfkyl	26	2	which	which	WDT
cord-292688-w4zvfkyl	26	3	are	be	VBP
cord-292688-w4zvfkyl	26	4	not	not	RB
cord-292688-w4zvfkyl	26	5	present	present	JJ
cord-292688-w4zvfkyl	26	6	in	in	IN
cord-292688-w4zvfkyl	26	7	regulated	regulate	VBN
cord-292688-w4zvfkyl	26	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	26	9	protein	protein	NN
cord-292688-w4zvfkyl	26	10	aggregates	aggregate	NNS
cord-292688-w4zvfkyl	26	11	,	,	,
cord-292688-w4zvfkyl	26	12	or	or	CC
cord-292688-w4zvfkyl	26	13	do	do	VBP
cord-292688-w4zvfkyl	26	14	not	not	RB
cord-292688-w4zvfkyl	26	15	interact	interact	VB
cord-292688-w4zvfkyl	26	16	with	with	IN
cord-292688-w4zvfkyl	26	17	the	the	DT
cord-292688-w4zvfkyl	26	18	recep	recep	NNP
cord-292688-w4zvfkyl	26	19	-	-	HYPH
cord-292688-w4zvfkyl	26	20	tor	tor	NNP
cord-292688-w4zvfkyl	26	21	for	for	IN
cord-292688-w4zvfkyl	26	22	the	the	DT
cord-292688-w4zvfkyl	26	23	regulated	regulate	VBN
cord-292688-w4zvfkyl	26	24	secretory	secretory	JJ
cord-292688-w4zvfkyl	26	25	proteins	protein	NNS
cord-292688-w4zvfkyl	26	26	,	,	,
cord-292688-w4zvfkyl	26	27	are	be	VBP
cord-292688-w4zvfkyl	26	28	thought	think	VBN
cord-292688-w4zvfkyl	26	29	to	to	TO
cord-292688-w4zvfkyl	26	30	exit	exit	VB
cord-292688-w4zvfkyl	26	31	the	the	DT
cord-292688-w4zvfkyl	26	32	TGN	TGN	NNP
cord-292688-w4zvfkyl	26	33	in	in	IN
cord-292688-w4zvfkyl	26	34	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	26	35	secretory	secretory	NN
cord-292688-w4zvfkyl	26	36	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	26	37	(	(	-LRB-
cord-292688-w4zvfkyl	26	38	CSVs	CSVs	NNP
cord-292688-w4zvfkyl	26	39	)	)	-RRB-
cord-292688-w4zvfkyl	26	40	.	.	.
cord-292688-w4zvfkyl	27	1	An	an	DT
cord-292688-w4zvfkyl	27	2	alternative	alternative	JJ
cord-292688-w4zvfkyl	27	3	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	27	4	is	be	VBZ
cord-292688-w4zvfkyl	27	5	that	that	IN
cord-292688-w4zvfkyl	27	6	there	there	EX
cord-292688-w4zvfkyl	27	7	is	be	VBZ
cord-292688-w4zvfkyl	27	8	very	very	RB
cord-292688-w4zvfkyl	27	9	little	little	JJ
cord-292688-w4zvfkyl	27	10	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	27	11	secretion	secretion	NN
cord-292688-w4zvfkyl	27	12	originating	originate	VBG
cord-292688-w4zvfkyl	27	13	from	from	IN
cord-292688-w4zvfkyl	27	14	the	the	DT
cord-292688-w4zvfkyl	27	15	TGN	TGN	NNP
cord-292688-w4zvfkyl	27	16	of	of	IN
cord-292688-w4zvfkyl	27	17	regulated	regulated	JJ
cord-292688-w4zvfkyl	27	18	cells	cell	NNS
cord-292688-w4zvfkyl	27	19	,	,	,
cord-292688-w4zvfkyl	27	20	and	and	CC
cord-292688-w4zvfkyl	27	21	that	that	IN
cord-292688-w4zvfkyl	27	22	most	most	JJS
cord-292688-w4zvfkyl	27	23	molecules	molecule	NNS
cord-292688-w4zvfkyl	27	24	in	in	IN
cord-292688-w4zvfkyl	27	25	the	the	DT
cord-292688-w4zvfkyl	27	26	biosynthetic	biosynthetic	JJ
cord-292688-w4zvfkyl	27	27	pathway	pathway	NN
cord-292688-w4zvfkyl	27	28	exit	exit	NN
cord-292688-w4zvfkyl	27	29	into	into	IN
cord-292688-w4zvfkyl	27	30	ISGs	isg	NNS
cord-292688-w4zvfkyl	27	31	.	.	.
cord-292688-w4zvfkyl	28	1	In	in	IN
cord-292688-w4zvfkyl	28	2	the	the	DT
cord-292688-w4zvfkyl	28	3	ISG	ISG	NNP
cord-292688-w4zvfkyl	28	4	,	,	,
cord-292688-w4zvfkyl	28	5	the	the	DT
cord-292688-w4zvfkyl	28	6	non	non	JJ
cord-292688-w4zvfkyl	28	7	-	-	JJ
cord-292688-w4zvfkyl	28	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	28	9	granule	granule	NN
cord-292688-w4zvfkyl	28	10	proteins	protein	NNS
cord-292688-w4zvfkyl	28	11	would	would	MD
cord-292688-w4zvfkyl	28	12	presumably	presumably	RB
cord-292688-w4zvfkyl	28	13	be	be	VB
cord-292688-w4zvfkyl	28	14	sorted	sort	VBN
cord-292688-w4zvfkyl	28	15	from	from	IN
cord-292688-w4zvfkyl	28	16	the	the	DT
cord-292688-w4zvfkyl	28	17	regulated	regulate	VBN
cord-292688-w4zvfkyl	28	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	28	19	proteins	protein	NNS
cord-292688-w4zvfkyl	28	20	via	via	IN
cord-292688-w4zvfkyl	28	21	interaction	interaction	NN
cord-292688-w4zvfkyl	28	22	with	with	IN
cord-292688-w4zvfkyl	28	23	a	a	DT
cord-292688-w4zvfkyl	28	24	receptor	receptor	NN
cord-292688-w4zvfkyl	28	25	and	and	CC
cord-292688-w4zvfkyl	28	26	removed	remove	VBN
cord-292688-w4zvfkyl	28	27	from	from	IN
cord-292688-w4zvfkyl	28	28	the	the	DT
cord-292688-w4zvfkyl	28	29	ISG	ISG	NNP
cord-292688-w4zvfkyl	28	30	in	in	IN
cord-292688-w4zvfkyl	28	31	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	28	32	-	-	HYPH
cord-292688-w4zvfkyl	28	33	like	like	JJ
cord-292688-w4zvfkyl	28	34	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	28	35	.	.	.
cord-292688-w4zvfkyl	29	1	Aggregation	aggregation	NN
cord-292688-w4zvfkyl	29	2	of	of	IN
cord-292688-w4zvfkyl	29	3	the	the	DT
cord-292688-w4zvfkyl	29	4	regulated	regulate	VBN
cord-292688-w4zvfkyl	29	5	secretory	secretory	JJ
cord-292688-w4zvfkyl	29	6	proteins	protein	NNS
cord-292688-w4zvfkyl	29	7	would	would	MD
cord-292688-w4zvfkyl	29	8	still	still	RB
cord-292688-w4zvfkyl	29	9	occur	occur	VB
cord-292688-w4zvfkyl	29	10	in	in	IN
cord-292688-w4zvfkyl	29	11	the	the	DT
cord-292688-w4zvfkyl	29	12	ISG	ISG	NNP
cord-292688-w4zvfkyl	29	13	and	and	CC
cord-292688-w4zvfkyl	29	14	would	would	MD
cord-292688-w4zvfkyl	29	15	function	function	VB
cord-292688-w4zvfkyl	29	16	to	to	TO
cord-292688-w4zvfkyl	29	17	allow	allow	VB
cord-292688-w4zvfkyl	29	18	retention	retention	NN
cord-292688-w4zvfkyl	29	19	in	in	IN
cord-292688-w4zvfkyl	29	20	the	the	DT
cord-292688-w4zvfkyl	29	21	ISG	ISG	NNP
cord-292688-w4zvfkyl	29	22	by	by	IN
cord-292688-w4zvfkyl	29	23	preventing	prevent	VBG
cord-292688-w4zvfkyl	29	24	any	any	DT
cord-292688-w4zvfkyl	29	25	interaction	interaction	NN
cord-292688-w4zvfkyl	29	26	with	with	IN
cord-292688-w4zvfkyl	29	27	receptors	receptor	NNS
cord-292688-w4zvfkyl	29	28	for	for	IN
cord-292688-w4zvfkyl	29	29	non	non	JJ
cord-292688-w4zvfkyl	29	30	-	-	JJ
cord-292688-w4zvfkyl	29	31	secretory	secretory	JJ
cord-292688-w4zvfkyl	29	32	granule	granule	NN
cord-292688-w4zvfkyl	29	33	proteins	protein	NNS
cord-292688-w4zvfkyl	29	34	.	.	.
cord-292688-w4zvfkyl	30	1	In	in	IN
cord-292688-w4zvfkyl	30	2	both	both	DT
cord-292688-w4zvfkyl	30	3	models	model	NNS
cord-292688-w4zvfkyl	30	4	,	,	,
cord-292688-w4zvfkyl	30	5	one	one	PRP
cord-292688-w4zvfkyl	30	6	could	could	MD
cord-292688-w4zvfkyl	30	7	make	make	VB
cord-292688-w4zvfkyl	30	8	predictions	prediction	NNS
cord-292688-w4zvfkyl	30	9	about	about	IN
cord-292688-w4zvfkyl	30	10	the	the	DT
cord-292688-w4zvfkyl	30	11	stoichiometry	stoichiometry	NN
cord-292688-w4zvfkyl	30	12	of	of	IN
cord-292688-w4zvfkyl	30	13	the	the	DT
cord-292688-w4zvfkyl	30	14	receptor	receptor	NN
cord-292688-w4zvfkyl	30	15	relative	relative	NN
cord-292688-w4zvfkyl	30	16	to	to	IN
cord-292688-w4zvfkyl	30	17	the	the	DT
cord-292688-w4zvfkyl	30	18	ligand	ligand	NN
cord-292688-w4zvfkyl	30	19	,	,	,
cord-292688-w4zvfkyl	30	20	depending	depend	VBG
cord-292688-w4zvfkyl	30	21	on	on	IN
cord-292688-w4zvfkyl	30	22	whether	whether	IN
cord-292688-w4zvfkyl	30	23	it	-PRON-	PRP
cord-292688-w4zvfkyl	30	24	is	be	VBZ
cord-292688-w4zvfkyl	30	25	a	a	DT
cord-292688-w4zvfkyl	30	26	single	single	JJ
cord-292688-w4zvfkyl	30	27	secretory	secretory	JJ
cord-292688-w4zvfkyl	30	28	protein	protein	NN
cord-292688-w4zvfkyl	30	29	interacting	interact	VBG
cord-292688-w4zvfkyl	30	30	with	with	IN
cord-292688-w4zvfkyl	30	31	a	a	DT
cord-292688-w4zvfkyl	30	32	single	single	JJ
cord-292688-w4zvfkyl	30	33	receptor	receptor	NN
cord-292688-w4zvfkyl	30	34	,	,	,
cord-292688-w4zvfkyl	30	35	or	or	CC
cord-292688-w4zvfkyl	30	36	an	an	DT
cord-292688-w4zvfkyl	30	37	aggregate	aggregate	NN
cord-292688-w4zvfkyl	30	38	of	of	IN
cord-292688-w4zvfkyl	30	39	regulated	regulate	VBN
cord-292688-w4zvfkyl	30	40	secretory	secretory	JJ
cord-292688-w4zvfkyl	30	41	proteins	protein	NNS
cord-292688-w4zvfkyl	30	42	interacting	interact	VBG
cord-292688-w4zvfkyl	30	43	with	with	IN
cord-292688-w4zvfkyl	30	44	a	a	DT
cord-292688-w4zvfkyl	30	45	single	single	JJ
cord-292688-w4zvfkyl	30	46	receptor	receptor	NN
cord-292688-w4zvfkyl	30	47	.	.	.
cord-292688-w4zvfkyl	31	1	In	in	IN
cord-292688-w4zvfkyl	31	2	both	both	DT
cord-292688-w4zvfkyl	31	3	models	model	NNS
cord-292688-w4zvfkyl	31	4	,	,	,
cord-292688-w4zvfkyl	31	5	interaction	interaction	NN
cord-292688-w4zvfkyl	31	6	with	with	IN
cord-292688-w4zvfkyl	31	7	a	a	DT
cord-292688-w4zvfkyl	31	8	receptor	receptor	NN
cord-292688-w4zvfkyl	31	9	would	would	MD
cord-292688-w4zvfkyl	31	10	allow	allow	VB
cord-292688-w4zvfkyl	31	11	removal	removal	NN
cord-292688-w4zvfkyl	31	12	of	of	IN
cord-292688-w4zvfkyl	31	13	non	non	JJ
cord-292688-w4zvfkyl	31	14	-	-	JJ
cord-292688-w4zvfkyl	31	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	31	16	granule	granule	NN
cord-292688-w4zvfkyl	31	17	proteins	protein	NNS
cord-292688-w4zvfkyl	31	18	from	from	IN
cord-292688-w4zvfkyl	31	19	the	the	DT
cord-292688-w4zvfkyl	31	20	forming	form	VBG
cord-292688-w4zvfkyl	31	21	or	or	CC
cord-292688-w4zvfkyl	31	22	maturing	mature	VBG
cord-292688-w4zvfkyl	31	23	secretory	secretory	JJ
cord-292688-w4zvfkyl	31	24	granule	granule	NN
cord-292688-w4zvfkyl	31	25	.	.	.
cord-292688-w4zvfkyl	32	1	An	an	DT
cord-292688-w4zvfkyl	32	2	important	important	JJ
cord-292688-w4zvfkyl	32	3	point	point	NN
cord-292688-w4zvfkyl	32	4	of	of	IN
cord-292688-w4zvfkyl	32	5	clari¢cation	clari¢cation	NN
cord-292688-w4zvfkyl	32	6	is	be	VBZ
cord-292688-w4zvfkyl	32	7	that	that	IN
cord-292688-w4zvfkyl	32	8	there	there	EX
cord-292688-w4zvfkyl	32	9	may	may	MD
cord-292688-w4zvfkyl	32	10	well	well	RB
cord-292688-w4zvfkyl	32	11	be	be	VB
cord-292688-w4zvfkyl	32	12	multiple	multiple	JJ
cord-292688-w4zvfkyl	32	13	classes	class	NNS
cord-292688-w4zvfkyl	32	14	of	of	IN
cord-292688-w4zvfkyl	32	15	receptors	receptor	NNS
cord-292688-w4zvfkyl	32	16	for	for	IN
cord-292688-w4zvfkyl	32	17	both	both	DT
cord-292688-w4zvfkyl	32	18	regulated	regulate	VBN
cord-292688-w4zvfkyl	32	19	secretory	secretory	JJ
cord-292688-w4zvfkyl	32	20	proteins	protein	NNS
cord-292688-w4zvfkyl	32	21	and	and	CC
cord-292688-w4zvfkyl	32	22	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	32	23	secretory	secretory	JJ
cord-292688-w4zvfkyl	32	24	proteins	protein	NNS
cord-292688-w4zvfkyl	32	25	in	in	IN
cord-292688-w4zvfkyl	32	26	the	the	DT
cord-292688-w4zvfkyl	32	27	TGN	TGN	NNP
cord-292688-w4zvfkyl	32	28	and	and	CC
cord-292688-w4zvfkyl	32	29	the	the	DT
cord-292688-w4zvfkyl	32	30	ISG	ISG	NNP
cord-292688-w4zvfkyl	32	31	.	.	.
cord-292688-w4zvfkyl	33	1	In	in	IN
cord-292688-w4zvfkyl	33	2	addition	addition	NN
cord-292688-w4zvfkyl	33	3	,	,	,
cord-292688-w4zvfkyl	33	4	interaction	interaction	NN
cord-292688-w4zvfkyl	33	5	of	of	IN
cord-292688-w4zvfkyl	33	6	any	any	DT
cord-292688-w4zvfkyl	33	7	ligand	ligand	NN
cord-292688-w4zvfkyl	33	8	with	with	IN
cord-292688-w4zvfkyl	33	9	its	-PRON-	PRP$
cord-292688-w4zvfkyl	33	10	receptor	receptor	NN
cord-292688-w4zvfkyl	33	11	is	be	VBZ
cord-292688-w4zvfkyl	33	12	most	most	RBS
cord-292688-w4zvfkyl	33	13	probably	probably	RB
cord-292688-w4zvfkyl	33	14	transient	transient	JJ
cord-292688-w4zvfkyl	33	15	and	and	CC
cord-292688-w4zvfkyl	33	16	disrupted	disrupt	VBD
cord-292688-w4zvfkyl	33	17	,	,	,
cord-292688-w4zvfkyl	33	18	for	for	IN
cord-292688-w4zvfkyl	33	19	example	example	NN
cord-292688-w4zvfkyl	33	20	,	,	,
cord-292688-w4zvfkyl	33	21	by	by	IN
cord-292688-w4zvfkyl	33	22	changes	change	NNS
cord-292688-w4zvfkyl	33	23	in	in	IN
cord-292688-w4zvfkyl	33	24	the	the	DT
cord-292688-w4zvfkyl	33	25	pH	ph	NN
cord-292688-w4zvfkyl	33	26	of	of	IN
cord-292688-w4zvfkyl	33	27	the	the	DT
cord-292688-w4zvfkyl	33	28	maturing	mature	VBG
cord-292688-w4zvfkyl	33	29	ISG	ISG	NNP
cord-292688-w4zvfkyl	33	30	.	.	.
cord-292688-w4zvfkyl	34	1	One	one	CD
cord-292688-w4zvfkyl	34	2	mechanism	mechanism	NN
cord-292688-w4zvfkyl	34	3	for	for	IN
cord-292688-w4zvfkyl	34	4	sorting	sort	VBG
cord-292688-w4zvfkyl	34	5	soluble	soluble	JJ
cord-292688-w4zvfkyl	34	6	secretory	secretory	JJ
cord-292688-w4zvfkyl	34	7	proteins	protein	NNS
cord-292688-w4zvfkyl	34	8	into	into	IN
cord-292688-w4zvfkyl	34	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	34	10	granules	granule	NNS
cord-292688-w4zvfkyl	34	11	is	be	VBZ
cord-292688-w4zvfkyl	34	12	via	via	IN
cord-292688-w4zvfkyl	34	13	a	a	DT
cord-292688-w4zvfkyl	34	14	selective	selective	JJ
cord-292688-w4zvfkyl	34	15	aggregation	aggregation	NN
cord-292688-w4zvfkyl	34	16	of	of	IN
cord-292688-w4zvfkyl	34	17	a	a	DT
cord-292688-w4zvfkyl	34	18	subset	subset	NN
cord-292688-w4zvfkyl	34	19	of	of	IN
cord-292688-w4zvfkyl	34	20	soluble	soluble	JJ
cord-292688-w4zvfkyl	34	21	proteins	protein	NNS
cord-292688-w4zvfkyl	34	22	to	to	IN
cord-292688-w4zvfkyl	34	23	the	the	DT
cord-292688-w4zvfkyl	34	24	exclusion	exclusion	NN
cord-292688-w4zvfkyl	34	25	of	of	IN
cord-292688-w4zvfkyl	34	26	other	other	JJ
cord-292688-w4zvfkyl	34	27	soluble	soluble	JJ
cord-292688-w4zvfkyl	34	28	,	,	,
cord-292688-w4zvfkyl	34	29	non	non	JJ
cord-292688-w4zvfkyl	34	30	-	-	JJ
cord-292688-w4zvfkyl	34	31	aggregating	aggregating	JJ
cord-292688-w4zvfkyl	34	32	secretory	secretory	JJ
cord-292688-w4zvfkyl	34	33	proteins	protein	NNS
cord-292688-w4zvfkyl	34	34	.	.	.
cord-292688-w4zvfkyl	35	1	For	for	IN
cord-292688-w4zvfkyl	35	2	e¤cient	e¤cient	NNP
cord-292688-w4zvfkyl	35	3	aggregation	aggregation	NN
cord-292688-w4zvfkyl	35	4	,	,	,
cord-292688-w4zvfkyl	35	5	the	the	DT
cord-292688-w4zvfkyl	35	6	local	local	JJ
cord-292688-w4zvfkyl	35	7	concentration	concentration	NN
cord-292688-w4zvfkyl	35	8	of	of	IN
cord-292688-w4zvfkyl	35	9	the	the	DT
cord-292688-w4zvfkyl	35	10	secretory	secretory	JJ
cord-292688-w4zvfkyl	35	11	proteins	protein	NNS
cord-292688-w4zvfkyl	35	12	should	should	MD
cord-292688-w4zvfkyl	35	13	be	be	VB
cord-292688-w4zvfkyl	35	14	high	high	JJ
cord-292688-w4zvfkyl	35	15	in	in	IN
cord-292688-w4zvfkyl	35	16	the	the	DT
cord-292688-w4zvfkyl	35	17	sorting	sorting	NN
cord-292688-w4zvfkyl	35	18	compartment	compartment	NN
cord-292688-w4zvfkyl	35	19	.	.	.
cord-292688-w4zvfkyl	36	1	Soluble	soluble	JJ
cord-292688-w4zvfkyl	36	2	regulated	regulate	VBN
cord-292688-w4zvfkyl	36	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	36	4	proteins	protein	NNS
cord-292688-w4zvfkyl	36	5	are	be	VBP
cord-292688-w4zvfkyl	36	6	for	for	IN
cord-292688-w4zvfkyl	36	7	the	the	DT
cord-292688-w4zvfkyl	36	8	most	most	JJS
cord-292688-w4zvfkyl	36	9	part	part	NN
cord-292688-w4zvfkyl	36	10	very	very	RB
cord-292688-w4zvfkyl	36	11	abundant	abundant	JJ
cord-292688-w4zvfkyl	36	12	in	in	IN
cord-292688-w4zvfkyl	36	13	cells	cell	NNS
cord-292688-w4zvfkyl	36	14	with	with	IN
cord-292688-w4zvfkyl	36	15	a	a	DT
cord-292688-w4zvfkyl	36	16	regulated	regulated	JJ
cord-292688-w4zvfkyl	36	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	36	18	pathway	pathway	NN
cord-292688-w4zvfkyl	36	19	.	.	.
cord-292688-w4zvfkyl	37	1	In	in	IN
cord-292688-w4zvfkyl	37	2	particular	particular	JJ
cord-292688-w4zvfkyl	37	3	,	,	,
cord-292688-w4zvfkyl	37	4	a	a	DT
cord-292688-w4zvfkyl	37	5	family	family	NN
cord-292688-w4zvfkyl	37	6	of	of	IN
cord-292688-w4zvfkyl	37	7	proteins	protein	NNS
cord-292688-w4zvfkyl	37	8	known	know	VBN
cord-292688-w4zvfkyl	37	9	as	as	IN
cord-292688-w4zvfkyl	37	10	the	the	DT
cord-292688-w4zvfkyl	37	11	granins	granin	NNS
cord-292688-w4zvfkyl	37	12	[	[	-LRB-
cord-292688-w4zvfkyl	37	13	1	1	CD
cord-292688-w4zvfkyl	37	14	]	]	-RRB-
cord-292688-w4zvfkyl	37	15	are	be	VBP
cord-292688-w4zvfkyl	37	16	highly	highly	RB
cord-292688-w4zvfkyl	37	17	expressed	express	VBN
cord-292688-w4zvfkyl	37	18	in	in	IN
cord-292688-w4zvfkyl	37	19	most	most	JJS
cord-292688-w4zvfkyl	37	20	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	37	21	and	and	CC
cord-292688-w4zvfkyl	37	22	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	37	23	cells	cell	NNS
cord-292688-w4zvfkyl	37	24	.	.	.
cord-292688-w4zvfkyl	38	1	The	the	DT
cord-292688-w4zvfkyl	38	2	members	member	NNS
cord-292688-w4zvfkyl	38	3	of	of	IN
cord-292688-w4zvfkyl	38	4	this	this	DT
cord-292688-w4zvfkyl	38	5	family	family	NN
cord-292688-w4zvfkyl	38	6	of	of	IN
cord-292688-w4zvfkyl	38	7	proteins	protein	NNS
cord-292688-w4zvfkyl	38	8	include	include	VBP
cord-292688-w4zvfkyl	38	9	chromogranin	chromogranin	NNS
cord-292688-w4zvfkyl	38	10	A	A	NNP
cord-292688-w4zvfkyl	38	11	(	(	-LRB-
cord-292688-w4zvfkyl	38	12	CgA	CgA	NNP
cord-292688-w4zvfkyl	38	13	)	)	-RRB-
cord-292688-w4zvfkyl	38	14	,	,	,
cord-292688-w4zvfkyl	38	15	chromogranin	chromogranin	NNP
cord-292688-w4zvfkyl	38	16	B	B	NNP
cord-292688-w4zvfkyl	38	17	(	(	-LRB-
cord-292688-w4zvfkyl	38	18	CgB	CgB	NNP
cord-292688-w4zvfkyl	38	19	)	)	-RRB-
cord-292688-w4zvfkyl	38	20	,	,	,
cord-292688-w4zvfkyl	38	21	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	38	22	II	II	NNP
cord-292688-w4zvfkyl	38	23	(	(	-LRB-
cord-292688-w4zvfkyl	38	24	SgII	SgII	NNP
cord-292688-w4zvfkyl	38	25	)	)	-RRB-
cord-292688-w4zvfkyl	38	26	,	,	,
cord-292688-w4zvfkyl	38	27	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	38	28	III	III	NNP
cord-292688-w4zvfkyl	38	29	,	,	,
cord-292688-w4zvfkyl	38	30	and	and	CC
cord-292688-w4zvfkyl	38	31	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	38	32	IV	IV	NNP
cord-292688-w4zvfkyl	38	33	(	(	-LRB-
cord-292688-w4zvfkyl	38	34	also	also	RB
cord-292688-w4zvfkyl	38	35	known	know	VBN
cord-292688-w4zvfkyl	38	36	as	as	IN
cord-292688-w4zvfkyl	38	37	7B2	7b2	CD
cord-292688-w4zvfkyl	38	38	)	)	-RRB-
cord-292688-w4zvfkyl	38	39	.	.	.
cord-292688-w4zvfkyl	39	1	Based	base	VBN
cord-292688-w4zvfkyl	39	2	on	on	IN
cord-292688-w4zvfkyl	39	3	the	the	DT
cord-292688-w4zvfkyl	39	4	primary	primary	JJ
cord-292688-w4zvfkyl	39	5	sequence	sequence	NN
cord-292688-w4zvfkyl	39	6	of	of	IN
cord-292688-w4zvfkyl	39	7	the	the	DT
cord-292688-w4zvfkyl	39	8	family	family	NN
cord-292688-w4zvfkyl	39	9	members	member	NNS
cord-292688-w4zvfkyl	39	10	,	,	,
cord-292688-w4zvfkyl	39	11	it	-PRON-	PRP
cord-292688-w4zvfkyl	39	12	is	be	VBZ
cord-292688-w4zvfkyl	39	13	thought	think	VBN
cord-292688-w4zvfkyl	39	14	they	-PRON-	PRP
cord-292688-w4zvfkyl	39	15	have	have	VBP
cord-292688-w4zvfkyl	39	16	similar	similar	JJ
cord-292688-w4zvfkyl	39	17	structural	structural	JJ
cord-292688-w4zvfkyl	39	18	features	feature	NNS
cord-292688-w4zvfkyl	39	19	which	which	WDT
cord-292688-w4zvfkyl	39	20	may	may	MD
cord-292688-w4zvfkyl	39	21	enable	enable	VB
cord-292688-w4zvfkyl	39	22	them	-PRON-	PRP
cord-292688-w4zvfkyl	39	23	to	to	TO
cord-292688-w4zvfkyl	39	24	e¤ciently	e¤ciently	RB
cord-292688-w4zvfkyl	39	25	aggregate	aggregate	VB
cord-292688-w4zvfkyl	39	26	in	in	IN
cord-292688-w4zvfkyl	39	27	the	the	DT
cord-292688-w4zvfkyl	39	28	TGN	TGN	NNP
cord-292688-w4zvfkyl	39	29	[	[	-LRB-
cord-292688-w4zvfkyl	39	30	2	2	CD
cord-292688-w4zvfkyl	39	31	]	]	-RRB-
cord-292688-w4zvfkyl	39	32	.	.	.
cord-292688-w4zvfkyl	40	1	Although	although	IN
cord-292688-w4zvfkyl	40	2	the	the	DT
cord-292688-w4zvfkyl	40	3	exact	exact	JJ
cord-292688-w4zvfkyl	40	4	function	function	NN
cord-292688-w4zvfkyl	40	5	of	of	IN
cord-292688-w4zvfkyl	40	6	the	the	DT
cord-292688-w4zvfkyl	40	7	granins	granin	NNS
cord-292688-w4zvfkyl	40	8	is	be	VBZ
cord-292688-w4zvfkyl	40	9	not	not	RB
cord-292688-w4zvfkyl	40	10	known	know	VBN
cord-292688-w4zvfkyl	40	11	,	,	,
cord-292688-w4zvfkyl	40	12	they	-PRON-	PRP
cord-292688-w4zvfkyl	40	13	might	may	MD
cord-292688-w4zvfkyl	40	14	be	be	VB
cord-292688-w4zvfkyl	40	15	acting	act	VBG
cord-292688-w4zvfkyl	40	16	as`helper	as`helper	JJ
cord-292688-w4zvfkyl	40	17	proteins	protein	NNS
cord-292688-w4zvfkyl	40	18	'	'	POS
cord-292688-w4zvfkyl	40	19	[	[	-LRB-
cord-292688-w4zvfkyl	40	20	3	3	CD
cord-292688-w4zvfkyl	40	21	]	]	-RRB-
cord-292688-w4zvfkyl	40	22	.	.	.
cord-292688-w4zvfkyl	41	1	If	if	IN
cord-292688-w4zvfkyl	41	2	sorting	sort	VBG
cord-292688-w4zvfkyl	41	3	only	only	RB
cord-292688-w4zvfkyl	41	4	occurs	occur	VBZ
cord-292688-w4zvfkyl	41	5	via	via	IN
cord-292688-w4zvfkyl	41	6	aggregation	aggregation	NN
cord-292688-w4zvfkyl	41	7	and	and	CC
cord-292688-w4zvfkyl	41	8	does	do	VBZ
cord-292688-w4zvfkyl	41	9	not	not	RB
cord-292688-w4zvfkyl	41	10	rely	rely	VB
cord-292688-w4zvfkyl	41	11	on	on	IN
cord-292688-w4zvfkyl	41	12	a	a	DT
cord-292688-w4zvfkyl	41	13	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	41	14	and	and	CC
cord-292688-w4zvfkyl	41	15	stoichiometric	stoichiometric	JJ
cord-292688-w4zvfkyl	41	16	receptor	receptor	NN
cord-292688-w4zvfkyl	41	17	-	-	HYPH
cord-292688-w4zvfkyl	41	18	ligand	ligand	NN
cord-292688-w4zvfkyl	41	19	interaction	interaction	NN
cord-292688-w4zvfkyl	41	20	,	,	,
cord-292688-w4zvfkyl	41	21	then	then	RB
cord-292688-w4zvfkyl	41	22	e¤cient	e¤cient	NNP
cord-292688-w4zvfkyl	41	23	sorting	sorting	NN
cord-292688-w4zvfkyl	41	24	of	of	IN
cord-292688-w4zvfkyl	41	25	prohormones	prohormone	NNS
cord-292688-w4zvfkyl	41	26	which	which	WDT
cord-292688-w4zvfkyl	41	27	either	either	CC
cord-292688-w4zvfkyl	41	28	have	have	VBP
cord-292688-w4zvfkyl	41	29	a	a	DT
cord-292688-w4zvfkyl	41	30	less	less	JJR
cord-292688-w4zvfkyl	41	31	than	than	IN
cord-292688-w4zvfkyl	41	32	optimal	optimal	JJ
cord-292688-w4zvfkyl	41	33	ability	ability	NN
cord-292688-w4zvfkyl	41	34	to	to	TO
cord-292688-w4zvfkyl	41	35	condense	condense	VB
cord-292688-w4zvfkyl	41	36	,	,	,
cord-292688-w4zvfkyl	41	37	or	or	CC
cord-292688-w4zvfkyl	41	38	are	be	VBP
cord-292688-w4zvfkyl	41	39	present	present	JJ
cord-292688-w4zvfkyl	41	40	at	at	IN
cord-292688-w4zvfkyl	41	41	very	very	RB
cord-292688-w4zvfkyl	41	42	low	low	JJ
cord-292688-w4zvfkyl	41	43	concentration	concentration	NN
cord-292688-w4zvfkyl	41	44	,	,	,
cord-292688-w4zvfkyl	41	45	might	may	MD
cord-292688-w4zvfkyl	41	46	be	be	VB
cord-292688-w4zvfkyl	41	47	enhanced	enhance	VBN
cord-292688-w4zvfkyl	41	48	by`helper	by`helper	NNP
cord-292688-w4zvfkyl	41	49	proteins	protein	NNS
cord-292688-w4zvfkyl	41	50	'	'	POS
cord-292688-w4zvfkyl	41	51	that	that	IN
cord-292688-w4zvfkyl	41	52	aid	aid	NN
cord-292688-w4zvfkyl	41	53	aggregate	aggregate	JJ
cord-292688-w4zvfkyl	41	54	formation	formation	NN
cord-292688-w4zvfkyl	41	55	.	.	.
cord-292688-w4zvfkyl	42	1	Recently	recently	RB
cord-292688-w4zvfkyl	42	2	,	,	,
cord-292688-w4zvfkyl	42	3	Natori	Natori	NNP
cord-292688-w4zvfkyl	42	4	and	and	CC
cord-292688-w4zvfkyl	42	5	Huttner	Huttner	NNP
cord-292688-w4zvfkyl	42	6	[	[	-LRB-
cord-292688-w4zvfkyl	42	7	4	4	CD
cord-292688-w4zvfkyl	42	8	]	]	-RRB-
cord-292688-w4zvfkyl	42	9	have	have	VBP
cord-292688-w4zvfkyl	42	10	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	42	11	that	that	IN
cord-292688-w4zvfkyl	42	12	increasing	increase	VBG
cord-292688-w4zvfkyl	42	13	the	the	DT
cord-292688-w4zvfkyl	42	14	amount	amount	NN
cord-292688-w4zvfkyl	42	15	of	of	IN
cord-292688-w4zvfkyl	42	16	CgB	cgb	NN
cord-292688-w4zvfkyl	42	17	in	in	IN
cord-292688-w4zvfkyl	42	18	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	42	19	cells	cell	NNS
cord-292688-w4zvfkyl	42	20	(	(	-LRB-
cord-292688-w4zvfkyl	42	21	a	a	DT
cord-292688-w4zvfkyl	42	22	cell	cell	NN
cord-292688-w4zvfkyl	42	23	line	line	NN
cord-292688-w4zvfkyl	42	24	derived	derive	VBN
cord-292688-w4zvfkyl	42	25	from	from	IN
cord-292688-w4zvfkyl	42	26	the	the	DT
cord-292688-w4zvfkyl	42	27	pituitary	pituitary	JJ
cord-292688-w4zvfkyl	42	28	corticotroph	corticotroph	NNS
cord-292688-w4zvfkyl	42	29	)	)	-RRB-
cord-292688-w4zvfkyl	42	30	indeed	indeed	RB
cord-292688-w4zvfkyl	42	31	promoted	promote	VBD
cord-292688-w4zvfkyl	42	32	e¤cient	e¤cient	NNP
cord-292688-w4zvfkyl	42	33	sorting	sorting	NN
cord-292688-w4zvfkyl	42	34	of	of	IN
cord-292688-w4zvfkyl	42	35	the	the	DT
cord-292688-w4zvfkyl	42	36	23	23	CD
cord-292688-w4zvfkyl	42	37	kDa	kDa	NNP
cord-292688-w4zvfkyl	42	38	POMC	POMC	NNP
cord-292688-w4zvfkyl	42	39	(	(	-LRB-
cord-292688-w4zvfkyl	42	40	pro	pro	JJ
cord-292688-w4zvfkyl	42	41	-	-	JJ
cord-292688-w4zvfkyl	42	42	opiomelanocortin	opiomelanocortin	JJ
cord-292688-w4zvfkyl	42	43	)	)	-RRB-
cord-292688-w4zvfkyl	42	44	fragment	fragment	NN
cord-292688-w4zvfkyl	42	45	into	into	IN
cord-292688-w4zvfkyl	42	46	secretory	secretory	JJ
cord-292688-w4zvfkyl	42	47	granules	granule	NNS
cord-292688-w4zvfkyl	42	48	,	,	,
cord-292688-w4zvfkyl	42	49	resulting	result	VBG
cord-292688-w4zvfkyl	42	50	in	in	IN
cord-292688-w4zvfkyl	42	51	increased	increase	VBN
cord-292688-w4zvfkyl	42	52	storage	storage	NN
cord-292688-w4zvfkyl	42	53	of	of	IN
cord-292688-w4zvfkyl	42	54	the	the	DT
cord-292688-w4zvfkyl	42	55	23	23	CD
cord-292688-w4zvfkyl	42	56	kDa	kDa	NNP
cord-292688-w4zvfkyl	42	57	POMC	POMC	NNP
cord-292688-w4zvfkyl	42	58	fragment	fragment	NN
cord-292688-w4zvfkyl	42	59	and	and	CC
cord-292688-w4zvfkyl	42	60	ACTH	ACTH	NNP
cord-292688-w4zvfkyl	42	61	.	.	.
cord-292688-w4zvfkyl	43	1	Aggregation	aggregation	NN
cord-292688-w4zvfkyl	43	2	of	of	IN
cord-292688-w4zvfkyl	43	3	SgII	SgII	NNP
cord-292688-w4zvfkyl	43	4	has	have	VBZ
cord-292688-w4zvfkyl	43	5	been	be	VBN
cord-292688-w4zvfkyl	43	6	shown	show	VBN
cord-292688-w4zvfkyl	43	7	in	in	IN
cord-292688-w4zvfkyl	43	8	vitro	vitro	FW
cord-292688-w4zvfkyl	43	9	as	as	RB
cord-292688-w4zvfkyl	43	10	well	well	RB
cord-292688-w4zvfkyl	43	11	as	as	IN
cord-292688-w4zvfkyl	43	12	in	in	IN
cord-292688-w4zvfkyl	43	13	permeabilized	permeabilized	JJ
cord-292688-w4zvfkyl	43	14	TGN	TGN	NNP
cord-292688-w4zvfkyl	43	15	membranes	membrane	NNS
cord-292688-w4zvfkyl	43	16	,	,	,
cord-292688-w4zvfkyl	43	17	under	under	IN
cord-292688-w4zvfkyl	43	18	conditions	condition	NNS
cord-292688-w4zvfkyl	43	19	(	(	-LRB-
cord-292688-w4zvfkyl	43	20	low	low	JJ
cord-292688-w4zvfkyl	43	21	pH	ph	NN
cord-292688-w4zvfkyl	43	22	,	,	,
cord-292688-w4zvfkyl	43	23	high	high	JJ
cord-292688-w4zvfkyl	43	24	Ca	Ca	NNP
cord-292688-w4zvfkyl	43	25	2	2	CD
cord-292688-w4zvfkyl	43	26	)	)	-RRB-
cord-292688-w4zvfkyl	43	27	believed	believe	VBN
cord-292688-w4zvfkyl	43	28	to	to	TO
cord-292688-w4zvfkyl	43	29	be	be	VB
cord-292688-w4zvfkyl	43	30	present	present	JJ
cord-292688-w4zvfkyl	43	31	in	in	IN
cord-292688-w4zvfkyl	43	32	the	the	DT
cord-292688-w4zvfkyl	43	33	lumenal	lumenal	JJ
cord-292688-w4zvfkyl	43	34	environment	environment	NN
cord-292688-w4zvfkyl	43	35	of	of	IN
cord-292688-w4zvfkyl	43	36	the	the	DT
cord-292688-w4zvfkyl	43	37	TGN	TGN	NNP
cord-292688-w4zvfkyl	43	38	[	[	-LRB-
cord-292688-w4zvfkyl	43	39	5	5	CD
cord-292688-w4zvfkyl	43	40	,	,	,
cord-292688-w4zvfkyl	43	41	6	6	CD
cord-292688-w4zvfkyl	43	42	]	]	-RRB-
cord-292688-w4zvfkyl	43	43	.	.	.
cord-292688-w4zvfkyl	44	1	Other	other	JJ
cord-292688-w4zvfkyl	44	2	soluble	soluble	JJ
cord-292688-w4zvfkyl	44	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	44	4	proteins	protein	NNS
cord-292688-w4zvfkyl	44	5	,	,	,
cord-292688-w4zvfkyl	44	6	other	other	JJ
cord-292688-w4zvfkyl	44	7	members	member	NNS
cord-292688-w4zvfkyl	44	8	of	of	IN
cord-292688-w4zvfkyl	44	9	the	the	DT
cord-292688-w4zvfkyl	44	10	granin	granin	NNP
cord-292688-w4zvfkyl	44	11	family	family	NN
cord-292688-w4zvfkyl	44	12	and	and	CC
cord-292688-w4zvfkyl	44	13	other	other	JJ
cord-292688-w4zvfkyl	44	14	proteins	protein	NNS
cord-292688-w4zvfkyl	44	15	found	find	VBN
cord-292688-w4zvfkyl	44	16	in	in	IN
cord-292688-w4zvfkyl	44	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	44	18	granules	granule	NNS
cord-292688-w4zvfkyl	44	19	,	,	,
cord-292688-w4zvfkyl	44	20	have	have	VBP
cord-292688-w4zvfkyl	44	21	also	also	RB
cord-292688-w4zvfkyl	44	22	been	be	VBN
cord-292688-w4zvfkyl	44	23	shown	show	VBN
cord-292688-w4zvfkyl	44	24	to	to	IN
cord-292688-w4zvfkyl	44	25	aggregate	aggregate	VB
cord-292688-w4zvfkyl	44	26	under	under	IN
cord-292688-w4zvfkyl	44	27	these	these	DT
cord-292688-w4zvfkyl	44	28	low	low	JJ
cord-292688-w4zvfkyl	44	29	pH	ph	NN
cord-292688-w4zvfkyl	44	30	,	,	,
cord-292688-w4zvfkyl	44	31	high	high	JJ
cord-292688-w4zvfkyl	44	32	Ca	Ca	NNP
cord-292688-w4zvfkyl	44	33	2	2	CD
cord-292688-w4zvfkyl	44	34	conditions	condition	NNS
cord-292688-w4zvfkyl	44	35	(	(	-LRB-
cord-292688-w4zvfkyl	44	36	see	see	VB
cord-292688-w4zvfkyl	44	37	e.g.	e.g.	JJ
cord-292688-w4zvfkyl	44	38	[	[	-LRB-
cord-292688-w4zvfkyl	44	39	7	7	CD
cord-292688-w4zvfkyl	44	40	,	,	,
cord-292688-w4zvfkyl	44	41	8	8	CD
cord-292688-w4zvfkyl	44	42	]	]	-RRB-
cord-292688-w4zvfkyl	44	43	)	)	-RRB-
cord-292688-w4zvfkyl	44	44	.	.	.
cord-292688-w4zvfkyl	45	1	Indeed	indeed	RB
cord-292688-w4zvfkyl	45	2	,	,	,
cord-292688-w4zvfkyl	45	3	morphological	morphological	JJ
cord-292688-w4zvfkyl	45	4	evidence	evidence	NN
cord-292688-w4zvfkyl	45	5	demonstrating	demonstrate	VBG
cord-292688-w4zvfkyl	45	6	the	the	DT
cord-292688-w4zvfkyl	45	7	presence	presence	NN
cord-292688-w4zvfkyl	45	8	of	of	IN
cord-292688-w4zvfkyl	45	9	aggregates	aggregate	NNS
cord-292688-w4zvfkyl	45	10	of	of	IN
cord-292688-w4zvfkyl	45	11	regulated	regulated	JJ
cord-292688-w4zvfkyl	45	12	secretory	secretory	JJ
cord-292688-w4zvfkyl	45	13	proteins	protein	NNS
cord-292688-w4zvfkyl	45	14	in	in	IN
cord-292688-w4zvfkyl	45	15	the	the	DT
cord-292688-w4zvfkyl	45	16	TGN	TGN	NNP
cord-292688-w4zvfkyl	45	17	[	[	-LRB-
cord-292688-w4zvfkyl	45	18	9	9	CD
cord-292688-w4zvfkyl	45	19	,	,	,
cord-292688-w4zvfkyl	45	20	10	10	CD
cord-292688-w4zvfkyl	45	21	]	]	-RRB-
cord-292688-w4zvfkyl	45	22	,	,	,
cord-292688-w4zvfkyl	45	23	but	but	CC
cord-292688-w4zvfkyl	45	24	not	not	RB
cord-292688-w4zvfkyl	45	25	in	in	IN
cord-292688-w4zvfkyl	45	26	earlier	early	JJR
cord-292688-w4zvfkyl	45	27	compartments	compartment	NNS
cord-292688-w4zvfkyl	45	28	under	under	IN
cord-292688-w4zvfkyl	45	29	normal	normal	JJ
cord-292688-w4zvfkyl	45	30	conditions	condition	NNS
cord-292688-w4zvfkyl	45	31	supports	support	VBZ
cord-292688-w4zvfkyl	45	32	both	both	CC
cord-292688-w4zvfkyl	45	33	the	the	DT
cord-292688-w4zvfkyl	45	34	location	location	NN
cord-292688-w4zvfkyl	45	35	of	of	IN
cord-292688-w4zvfkyl	45	36	the	the	DT
cord-292688-w4zvfkyl	45	37	initiation	initiation	NN
cord-292688-w4zvfkyl	45	38	of	of	IN
cord-292688-w4zvfkyl	45	39	aggregation	aggregation	NN
cord-292688-w4zvfkyl	45	40	and	and	CC
cord-292688-w4zvfkyl	45	41	its	-PRON-	PRP$
cord-292688-w4zvfkyl	45	42	role	role	NN
cord-292688-w4zvfkyl	45	43	in	in	IN
cord-292688-w4zvfkyl	45	44	sorting	sorting	NN
cord-292688-w4zvfkyl	45	45	.	.	.
cord-292688-w4zvfkyl	46	1	Experiments	experiment	NNS
cord-292688-w4zvfkyl	46	2	performed	perform	VBD
cord-292688-w4zvfkyl	46	3	several	several	JJ
cord-292688-w4zvfkyl	46	4	years	year	NNS
cord-292688-w4zvfkyl	46	5	ago	ago	RB
cord-292688-w4zvfkyl	46	6	with	with	IN
cord-292688-w4zvfkyl	46	7	weak	weak	JJ
cord-292688-w4zvfkyl	46	8	bases	basis	NNS
cord-292688-w4zvfkyl	46	9	,	,	,
cord-292688-w4zvfkyl	46	10	such	such	JJ
cord-292688-w4zvfkyl	46	11	as	as	IN
cord-292688-w4zvfkyl	46	12	chloroquine	chloroquine	NN
cord-292688-w4zvfkyl	46	13	and	and	CC
cord-292688-w4zvfkyl	46	14	ammonium	ammonium	NN
cord-292688-w4zvfkyl	46	15	chloride	chloride	NN
cord-292688-w4zvfkyl	46	16	argued	argue	VBD
cord-292688-w4zvfkyl	46	17	that	that	IN
cord-292688-w4zvfkyl	46	18	perturbation	perturbation	NN
cord-292688-w4zvfkyl	46	19	of	of	IN
cord-292688-w4zvfkyl	46	20	the	the	DT
cord-292688-w4zvfkyl	46	21	pH	ph	NN
cord-292688-w4zvfkyl	46	22	in	in	IN
cord-292688-w4zvfkyl	46	23	the	the	DT
cord-292688-w4zvfkyl	46	24	TGN	TGN	NNP
cord-292688-w4zvfkyl	46	25	caused	cause	VBN
cord-292688-w4zvfkyl	46	26	missorting	missorting	NN
cord-292688-w4zvfkyl	46	27	of	of	IN
cord-292688-w4zvfkyl	46	28	regulated	regulated	JJ
cord-292688-w4zvfkyl	46	29	secretory	secretory	JJ
cord-292688-w4zvfkyl	46	30	proteins	protein	NNS
cord-292688-w4zvfkyl	46	31	into	into	IN
cord-292688-w4zvfkyl	46	32	the	the	DT
cord-292688-w4zvfkyl	46	33	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	46	34	pathway	pathway	NN
cord-292688-w4zvfkyl	46	35	(	(	-LRB-
cord-292688-w4zvfkyl	46	36	see	see	VB
cord-292688-w4zvfkyl	46	37	for	for	IN
cord-292688-w4zvfkyl	46	38	example	example	NN
cord-292688-w4zvfkyl	46	39	[	[	-LRB-
cord-292688-w4zvfkyl	46	40	11	11	CD
cord-292688-w4zvfkyl	46	41	]	]	-RRB-
cord-292688-w4zvfkyl	46	42	)	)	-RRB-
cord-292688-w4zvfkyl	46	43	.	.	.
cord-292688-w4zvfkyl	47	1	Although	although	IN
cord-292688-w4zvfkyl	47	2	the	the	DT
cord-292688-w4zvfkyl	47	3	data	datum	NNS
cord-292688-w4zvfkyl	47	4	did	do	VBD
cord-292688-w4zvfkyl	47	5	not	not	RB
cord-292688-w4zvfkyl	47	6	gain	gain	VB
cord-292688-w4zvfkyl	47	7	complete	complete	JJ
cord-292688-w4zvfkyl	47	8	support	support	NN
cord-292688-w4zvfkyl	47	9	[	[	-LRB-
cord-292688-w4zvfkyl	47	10	12	12	CD
cord-292688-w4zvfkyl	47	11	]	]	-RRB-
cord-292688-w4zvfkyl	47	12	these	these	DT
cord-292688-w4zvfkyl	47	13	experiments	experiment	NNS
cord-292688-w4zvfkyl	47	14	were	be	VBD
cord-292688-w4zvfkyl	47	15	the	the	DT
cord-292688-w4zvfkyl	47	16	¢rst	¢rst	CD
cord-292688-w4zvfkyl	47	17	to	to	TO
cord-292688-w4zvfkyl	47	18	suggest	suggest	VB
cord-292688-w4zvfkyl	47	19	that	that	IN
cord-292688-w4zvfkyl	47	20	pH	pH	NNP
cord-292688-w4zvfkyl	47	21	may	may	MD
cord-292688-w4zvfkyl	47	22	have	have	VB
cord-292688-w4zvfkyl	47	23	a	a	DT
cord-292688-w4zvfkyl	47	24	role	role	NN
cord-292688-w4zvfkyl	47	25	in	in	IN
cord-292688-w4zvfkyl	47	26	the	the	DT
cord-292688-w4zvfkyl	47	27	sorting	sorting	NN
cord-292688-w4zvfkyl	47	28	of	of	IN
cord-292688-w4zvfkyl	47	29	soluble	soluble	JJ
cord-292688-w4zvfkyl	47	30	proteins	protein	NNS
cord-292688-w4zvfkyl	47	31	.	.	.
cord-292688-w4zvfkyl	48	1	More	More	JJR
cord-292688-w4zvfkyl	48	2	recent	recent	JJ
cord-292688-w4zvfkyl	48	3	results	result	NNS
cord-292688-w4zvfkyl	48	4	obtained	obtain	VBN
cord-292688-w4zvfkyl	48	5	with	with	IN
cord-292688-w4zvfkyl	48	6	streptolysin	streptolysin	NNP
cord-292688-w4zvfkyl	48	7	O	O	NNP
cord-292688-w4zvfkyl	48	8	-	-	HYPH
cord-292688-w4zvfkyl	48	9	permeabilized	permeabilized	JJ
cord-292688-w4zvfkyl	48	10	PC12	PC12	NNP
cord-292688-w4zvfkyl	48	11	cells	cell	NNS
cord-292688-w4zvfkyl	48	12	support	support	VBP
cord-292688-w4zvfkyl	48	13	the	the	DT
cord-292688-w4zvfkyl	48	14	idea	idea	NN
cord-292688-w4zvfkyl	48	15	in	in	IN
cord-292688-w4zvfkyl	48	16	that	that	DT
cord-292688-w4zvfkyl	48	17	pH	pH	NNP
cord-292688-w4zvfkyl	48	18	may	may	MD
cord-292688-w4zvfkyl	48	19	be	be	VB
cord-292688-w4zvfkyl	48	20	crucial	crucial	JJ
cord-292688-w4zvfkyl	48	21	for	for	IN
cord-292688-w4zvfkyl	48	22	sorting	sorting	NN
cord-292688-w4zvfkyl	48	23	of	of	IN
cord-292688-w4zvfkyl	48	24	regulated	regulated	JJ
cord-292688-w4zvfkyl	48	25	secretory	secretory	JJ
cord-292688-w4zvfkyl	48	26	proteins	protein	NNS
cord-292688-w4zvfkyl	48	27	in	in	IN
cord-292688-w4zvfkyl	48	28	the	the	DT
cord-292688-w4zvfkyl	48	29	TGN	TGN	NNP
cord-292688-w4zvfkyl	48	30	[	[	-LRB-
cord-292688-w4zvfkyl	48	31	13	13	CD
cord-292688-w4zvfkyl	48	32	]	]	-RRB-
cord-292688-w4zvfkyl	48	33	.	.	.
cord-292688-w4zvfkyl	49	1	Concerning	concern	VBG
cord-292688-w4zvfkyl	49	2	the	the	DT
cord-292688-w4zvfkyl	49	3	exact	exact	JJ
cord-292688-w4zvfkyl	49	4	pH	ph	NN
cord-292688-w4zvfkyl	49	5	and	and	CC
cord-292688-w4zvfkyl	49	6	Ca	Ca	NNP
cord-292688-w4zvfkyl	49	7	2	2	CD
cord-292688-w4zvfkyl	49	8	requirements	requirement	NNS
cord-292688-w4zvfkyl	49	9	in	in	IN
cord-292688-w4zvfkyl	49	10	vivo	vivo	NN
cord-292688-w4zvfkyl	49	11	,	,	,
cord-292688-w4zvfkyl	49	12	values	value	NNS
cord-292688-w4zvfkyl	49	13	for	for	IN
cord-292688-w4zvfkyl	49	14	the	the	DT
cord-292688-w4zvfkyl	49	15	pH	ph	NN
cord-292688-w4zvfkyl	49	16	in	in	IN
cord-292688-w4zvfkyl	49	17	the	the	DT
cord-292688-w4zvfkyl	49	18	TGN	TGN	NNP
cord-292688-w4zvfkyl	49	19	of	of	IN
cord-292688-w4zvfkyl	49	20	cells	cell	NNS
cord-292688-w4zvfkyl	49	21	lacking	lack	VBG
cord-292688-w4zvfkyl	49	22	a	a	DT
cord-292688-w4zvfkyl	49	23	regulated	regulated	JJ
cord-292688-w4zvfkyl	49	24	secretory	secretory	JJ
cord-292688-w4zvfkyl	49	25	pathway	pathway	NN
cord-292688-w4zvfkyl	49	26	have	have	VBP
cord-292688-w4zvfkyl	49	27	been	be	VBN
cord-292688-w4zvfkyl	49	28	proposed	propose	VBN
cord-292688-w4zvfkyl	49	29	in	in	IN
cord-292688-w4zvfkyl	49	30	two	two	CD
cord-292688-w4zvfkyl	49	31	recent	recent	JJ
cord-292688-w4zvfkyl	49	32	studies	study	NNS
cord-292688-w4zvfkyl	49	33	(	(	-LRB-
cord-292688-w4zvfkyl	49	34	6.17	6.17	CD
cord-292688-w4zvfkyl	49	35	þ	þ	CD
cord-292688-w4zvfkyl	49	36	0.02	0.02	CD
cord-292688-w4zvfkyl	49	37	and	and	CC
cord-292688-w4zvfkyl	49	38	6.45	6.45	CD
cord-292688-w4zvfkyl	49	39	þ	þ	CD
cord-292688-w4zvfkyl	49	40	0.03	0.03	CD
cord-292688-w4zvfkyl	49	41	)	)	-RRB-
cord-292688-w4zvfkyl	49	42	[	[	-LRB-
cord-292688-w4zvfkyl	49	43	14	14	CD
cord-292688-w4zvfkyl	49	44	,	,	,
cord-292688-w4zvfkyl	49	45	15	15	CD
cord-292688-w4zvfkyl	49	46	]	]	-RRB-
cord-292688-w4zvfkyl	49	47	supporting	support	VBG
cord-292688-w4zvfkyl	49	48	the	the	DT
cord-292688-w4zvfkyl	49	49	notion	notion	NN
cord-292688-w4zvfkyl	49	50	that	that	IN
cord-292688-w4zvfkyl	49	51	the	the	DT
cord-292688-w4zvfkyl	49	52	TGN	TGN	NNP
cord-292688-w4zvfkyl	49	53	is	be	VBZ
cord-292688-w4zvfkyl	49	54	slightly	slightly	RB
cord-292688-w4zvfkyl	49	55	more	more	RBR
cord-292688-w4zvfkyl	49	56	acidic	acidic	JJ
cord-292688-w4zvfkyl	49	57	than	than	IN
cord-292688-w4zvfkyl	49	58	previous	previous	JJ
cord-292688-w4zvfkyl	49	59	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	49	60	compartments	compartment	NNS
cord-292688-w4zvfkyl	49	61	,	,	,
cord-292688-w4zvfkyl	49	62	but	but	CC
cord-292688-w4zvfkyl	49	63	there	there	EX
cord-292688-w4zvfkyl	49	64	are	be	VBP
cord-292688-w4zvfkyl	49	65	still	still	RB
cord-292688-w4zvfkyl	49	66	no	no	DT
cord-292688-w4zvfkyl	49	67	data	datum	NNS
cord-292688-w4zvfkyl	49	68	available	available	JJ
cord-292688-w4zvfkyl	49	69	on	on	IN
cord-292688-w4zvfkyl	49	70	the	the	DT
cord-292688-w4zvfkyl	49	71	free	free	JJ
cord-292688-w4zvfkyl	49	72	Ca	Ca	NNP
cord-292688-w4zvfkyl	49	73	2	2	CD
cord-292688-w4zvfkyl	49	74	concentration	concentration	NN
cord-292688-w4zvfkyl	49	75	in	in	IN
cord-292688-w4zvfkyl	49	76	the	the	DT
cord-292688-w4zvfkyl	49	77	lumen	lumen	NN
cord-292688-w4zvfkyl	49	78	of	of	IN
cord-292688-w4zvfkyl	49	79	the	the	DT
cord-292688-w4zvfkyl	49	80	TGN	TGN	NNP
cord-292688-w4zvfkyl	49	81	.	.	.
cord-292688-w4zvfkyl	50	1	Interpretation	interpretation	NN
cord-292688-w4zvfkyl	50	2	of	of	IN
cord-292688-w4zvfkyl	50	3	all	all	PDT
cord-292688-w4zvfkyl	50	4	these	these	DT
cord-292688-w4zvfkyl	50	5	results	result	NNS
cord-292688-w4zvfkyl	50	6	to	to	TO
cord-292688-w4zvfkyl	50	7	determine	determine	VB
cord-292688-w4zvfkyl	50	8	the	the	DT
cord-292688-w4zvfkyl	50	9	precise	precise	JJ
cord-292688-w4zvfkyl	50	10	role	role	NN
cord-292688-w4zvfkyl	50	11	of	of	IN
cord-292688-w4zvfkyl	50	12	pH	pH	NNP
cord-292688-w4zvfkyl	51	1	and	and	CC
cord-292688-w4zvfkyl	51	2	Ca	Ca	NNP
cord-292688-w4zvfkyl	51	3	2	2	CD
cord-292688-w4zvfkyl	51	4	in	in	IN
cord-292688-w4zvfkyl	51	5	the	the	DT
cord-292688-w4zvfkyl	51	6	TGN	TGN	NNP
cord-292688-w4zvfkyl	51	7	requires	require	VBZ
cord-292688-w4zvfkyl	51	8	accurate	accurate	JJ
cord-292688-w4zvfkyl	51	9	measurements	measurement	NNS
cord-292688-w4zvfkyl	51	10	for	for	IN
cord-292688-w4zvfkyl	51	11	pH	ph	NN
cord-292688-w4zvfkyl	52	1	and	and	CC
cord-292688-w4zvfkyl	52	2	Ca	Ca	NNP
cord-292688-w4zvfkyl	52	3	2	2	CD
cord-292688-w4zvfkyl	52	4	in	in	IN
cord-292688-w4zvfkyl	52	5	the	the	DT
cord-292688-w4zvfkyl	52	6	lumen	lumen	NN
cord-292688-w4zvfkyl	52	7	of	of	IN
cord-292688-w4zvfkyl	52	8	the	the	DT
cord-292688-w4zvfkyl	52	9	TGN	TGN	NNP
cord-292688-w4zvfkyl	52	10	in	in	IN
cord-292688-w4zvfkyl	52	11	cells	cell	NNS
cord-292688-w4zvfkyl	52	12	with	with	IN
cord-292688-w4zvfkyl	52	13	a	a	DT
cord-292688-w4zvfkyl	52	14	regulated	regulated	JJ
cord-292688-w4zvfkyl	52	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	52	16	pathway	pathway	NN
cord-292688-w4zvfkyl	52	17	.	.	.
cord-292688-w4zvfkyl	53	1	Some	some	DT
cord-292688-w4zvfkyl	53	2	controversy	controversy	NN
cord-292688-w4zvfkyl	53	3	exists	exist	VBZ
cord-292688-w4zvfkyl	53	4	concerning	concern	VBG
cord-292688-w4zvfkyl	53	5	the	the	DT
cord-292688-w4zvfkyl	53	6	role	role	NN
cord-292688-w4zvfkyl	53	7	of	of	IN
cord-292688-w4zvfkyl	53	8	the	the	DT
cord-292688-w4zvfkyl	53	9	TGN	TGN	NNP
cord-292688-w4zvfkyl	53	10	-	-	HYPH
cord-292688-w4zvfkyl	53	11	localized	localize	VBN
cord-292688-w4zvfkyl	53	12	aggregation	aggregation	NN
cord-292688-w4zvfkyl	53	13	event	event	NN
cord-292688-w4zvfkyl	53	14	in	in	IN
cord-292688-w4zvfkyl	53	15	sorting	sorting	NN
cord-292688-w4zvfkyl	53	16	which	which	WDT
cord-292688-w4zvfkyl	53	17	may	may	MD
cord-292688-w4zvfkyl	53	18	relate	relate	VB
cord-292688-w4zvfkyl	53	19	to	to	IN
cord-292688-w4zvfkyl	53	20	di¡erences	di¡erence	NNS
cord-292688-w4zvfkyl	53	21	between	between	IN
cord-292688-w4zvfkyl	53	22	the	the	DT
cord-292688-w4zvfkyl	53	23	cellular	cellular	JJ
cord-292688-w4zvfkyl	53	24	systems	system	NNS
cord-292688-w4zvfkyl	53	25	studied	study	VBD
cord-292688-w4zvfkyl	53	26	.	.	.
cord-292688-w4zvfkyl	54	1	L	L	NNP
cord-292688-w4zvfkyl	54	2	-	-	HYPH
cord-292688-w4zvfkyl	54	3	Cells	cell	NNS
cord-292688-w4zvfkyl	54	4	of	of	IN
cord-292688-w4zvfkyl	54	5	the	the	DT
cord-292688-w4zvfkyl	54	6	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	54	7	pancreas	pancrea	NNS
cord-292688-w4zvfkyl	54	8	secrete	secrete	VBP
cord-292688-w4zvfkyl	54	9	large	large	JJ
cord-292688-w4zvfkyl	54	10	quantities	quantity	NNS
cord-292688-w4zvfkyl	54	11	of	of	IN
cord-292688-w4zvfkyl	54	12	insulin	insulin	NN
cord-292688-w4zvfkyl	54	13	[	[	-LRB-
cord-292688-w4zvfkyl	54	14	16	16	CD
cord-292688-w4zvfkyl	54	15	]	]	-RRB-
cord-292688-w4zvfkyl	54	16	.	.	.
cord-292688-w4zvfkyl	55	1	Insulin	insulin	NN
cord-292688-w4zvfkyl	55	2	forms	form	VBZ
cord-292688-w4zvfkyl	55	3	insoluble	insoluble	JJ
cord-292688-w4zvfkyl	55	4	,	,	,
cord-292688-w4zvfkyl	55	5	close	close	JJ
cord-292688-w4zvfkyl	55	6	packed	pack	VBN
cord-292688-w4zvfkyl	55	7	crystalline	crystalline	JJ
cord-292688-w4zvfkyl	55	8	arrays	array	NNS
cord-292688-w4zvfkyl	55	9	in	in	IN
cord-292688-w4zvfkyl	55	10	the	the	DT
cord-292688-w4zvfkyl	55	11	presence	presence	NN
cord-292688-w4zvfkyl	55	12	of	of	IN
cord-292688-w4zvfkyl	55	13	zinc	zinc	NN
cord-292688-w4zvfkyl	55	14	,	,	,
cord-292688-w4zvfkyl	55	15	whereas	whereas	IN
cord-292688-w4zvfkyl	55	16	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	55	17	has	have	VBZ
cord-292688-w4zvfkyl	55	18	distinct	distinct	JJ
cord-292688-w4zvfkyl	55	19	physical	physical	JJ
cord-292688-w4zvfkyl	55	20	properties	property	NNS
cord-292688-w4zvfkyl	55	21	which	which	WDT
cord-292688-w4zvfkyl	55	22	prevent	prevent	VBP
cord-292688-w4zvfkyl	55	23	its	-PRON-	PRP$
cord-292688-w4zvfkyl	55	24	condensation	condensation	NN
cord-292688-w4zvfkyl	55	25	into	into	IN
cord-292688-w4zvfkyl	55	26	insoluble	insoluble	JJ
cord-292688-w4zvfkyl	55	27	crystals	crystal	NNS
cord-292688-w4zvfkyl	55	28	.	.	.
cord-292688-w4zvfkyl	56	1	Processing	processing	NN
cord-292688-w4zvfkyl	56	2	of	of	IN
cord-292688-w4zvfkyl	56	3	proinsulin	proinsulin	NN
cord-292688-w4zvfkyl	56	4	to	to	IN
cord-292688-w4zvfkyl	56	5	insulin	insulin	NN
cord-292688-w4zvfkyl	56	6	,	,	,
cord-292688-w4zvfkyl	56	7	which	which	WDT
cord-292688-w4zvfkyl	56	8	requires	require	VBZ
cord-292688-w4zvfkyl	56	9	two	two	CD
cord-292688-w4zvfkyl	56	10	processing	processing	NN
cord-292688-w4zvfkyl	56	11	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	56	12	,	,	,
cord-292688-w4zvfkyl	56	13	prohormone	prohormone	NN
cord-292688-w4zvfkyl	56	14	converting	convert	VBG
cord-292688-w4zvfkyl	56	15	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	56	16	(	(	-LRB-
cord-292688-w4zvfkyl	56	17	PCs	pc	NNS
cord-292688-w4zvfkyl	56	18	)	)	-RRB-
cord-292688-w4zvfkyl	56	19	1	1	CD
cord-292688-w4zvfkyl	56	20	and	and	CC
cord-292688-w4zvfkyl	56	21	2	2	CD
cord-292688-w4zvfkyl	56	22	,	,	,
cord-292688-w4zvfkyl	56	23	acting	act	VBG
cord-292688-w4zvfkyl	56	24	at	at	IN
cord-292688-w4zvfkyl	56	25	two	two	CD
cord-292688-w4zvfkyl	56	26	distinct	distinct	JJ
cord-292688-w4zvfkyl	56	27	sites	site	NNS
cord-292688-w4zvfkyl	56	28	(	(	-LRB-
cord-292688-w4zvfkyl	56	29	for	for	IN
cord-292688-w4zvfkyl	56	30	review	review	NN
cord-292688-w4zvfkyl	56	31	see	see	VB
cord-292688-w4zvfkyl	56	32	[	[	-LRB-
cord-292688-w4zvfkyl	56	33	17	17	CD
cord-292688-w4zvfkyl	56	34	]	]	-RRB-
cord-292688-w4zvfkyl	56	35	)	)	-RRB-
cord-292688-w4zvfkyl	56	36	,	,	,
cord-292688-w4zvfkyl	56	37	is	be	VBZ
cord-292688-w4zvfkyl	56	38	crucial	crucial	JJ
cord-292688-w4zvfkyl	56	39	for	for	IN
cord-292688-w4zvfkyl	56	40	the	the	DT
cord-292688-w4zvfkyl	56	41	condensation	condensation	NN
cord-292688-w4zvfkyl	56	42	of	of	IN
cord-292688-w4zvfkyl	56	43	insulin	insulin	NN
cord-292688-w4zvfkyl	56	44	.	.	.
cord-292688-w4zvfkyl	57	1	However	however	RB
cord-292688-w4zvfkyl	57	2	,	,	,
cord-292688-w4zvfkyl	57	3	the	the	DT
cord-292688-w4zvfkyl	57	4	intracellular	intracellular	JJ
cord-292688-w4zvfkyl	57	5	location	location	NN
cord-292688-w4zvfkyl	57	6	where	where	WRB
cord-292688-w4zvfkyl	57	7	processing	processing	NN
cord-292688-w4zvfkyl	57	8	of	of	IN
cord-292688-w4zvfkyl	57	9	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	57	10	and	and	CC
cord-292688-w4zvfkyl	57	11	other	other	JJ
cord-292688-w4zvfkyl	57	12	prohormones	prohormone	NNS
cord-292688-w4zvfkyl	57	13	begins	begin	VBZ
cord-292688-w4zvfkyl	57	14	is	be	VBZ
cord-292688-w4zvfkyl	57	15	unresolved	unresolved	JJ
cord-292688-w4zvfkyl	57	16	.	.	.
cord-292688-w4zvfkyl	58	1	There	there	EX
cord-292688-w4zvfkyl	58	2	are	be	VBP
cord-292688-w4zvfkyl	58	3	reports	report	NNS
cord-292688-w4zvfkyl	58	4	which	which	WDT
cord-292688-w4zvfkyl	58	5	demonstrate	demonstrate	VBP
cord-292688-w4zvfkyl	58	6	that	that	IN
cord-292688-w4zvfkyl	58	7	processing	processing	NN
cord-292688-w4zvfkyl	58	8	of	of	IN
cord-292688-w4zvfkyl	58	9	prohormones	prohormone	NNS
cord-292688-w4zvfkyl	58	10	by	by	IN
cord-292688-w4zvfkyl	58	11	PC	pc	NN
cord-292688-w4zvfkyl	58	12	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	58	13	can	can	MD
cord-292688-w4zvfkyl	58	14	begin	begin	VB
cord-292688-w4zvfkyl	58	15	in	in	IN
cord-292688-w4zvfkyl	58	16	the	the	DT
cord-292688-w4zvfkyl	58	17	TGN	TGN	NNP
cord-292688-w4zvfkyl	58	18	[	[	-LRB-
cord-292688-w4zvfkyl	58	19	4	4	CD
cord-292688-w4zvfkyl	58	20	,	,	,
cord-292688-w4zvfkyl	58	21	18	18	CD
cord-292688-w4zvfkyl	58	22	,	,	,
cord-292688-w4zvfkyl	58	23	19	19	CD
cord-292688-w4zvfkyl	58	24	]	]	-RRB-
cord-292688-w4zvfkyl	58	25	whereas	whereas	IN
cord-292688-w4zvfkyl	58	26	other	other	JJ
cord-292688-w4zvfkyl	58	27	studies	study	NNS
cord-292688-w4zvfkyl	58	28	indicate	indicate	VBP
cord-292688-w4zvfkyl	58	29	that	that	IN
cord-292688-w4zvfkyl	58	30	processing	processing	NN
cord-292688-w4zvfkyl	58	31	is	be	VBZ
cord-292688-w4zvfkyl	58	32	initiated	initiate	VBN
cord-292688-w4zvfkyl	58	33	in	in	IN
cord-292688-w4zvfkyl	58	34	the	the	DT
cord-292688-w4zvfkyl	58	35	ISG	ISG	NNP
cord-292688-w4zvfkyl	58	36	[	[	-LRB-
cord-292688-w4zvfkyl	58	37	20	20	CD
cord-292688-w4zvfkyl	58	38	^	^	SYM
cord-292688-w4zvfkyl	58	39	22	22	CD
cord-292688-w4zvfkyl	58	40	]	]	-RRB-
cord-292688-w4zvfkyl	58	41	.	.	.
cord-292688-w4zvfkyl	59	1	Proinsulin	proinsulin	JJ
cord-292688-w4zvfkyl	59	2	conversion	conversion	NN
cord-292688-w4zvfkyl	59	3	has	have	VBZ
cord-292688-w4zvfkyl	59	4	been	be	VBN
cord-292688-w4zvfkyl	59	5	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	59	6	to	to	TO
cord-292688-w4zvfkyl	59	7	occur	occur	VB
cord-292688-w4zvfkyl	59	8	only	only	RB
cord-292688-w4zvfkyl	59	9	in	in	IN
cord-292688-w4zvfkyl	59	10	secretory	secretory	JJ
cord-292688-w4zvfkyl	59	11	granules	granule	NNS
cord-292688-w4zvfkyl	59	12	(	(	-LRB-
cord-292688-w4zvfkyl	59	13	[	[	-LRB-
cord-292688-w4zvfkyl	59	14	23	23	CD
cord-292688-w4zvfkyl	59	15	^	^	SYM
cord-292688-w4zvfkyl	59	16	25	25	CD
cord-292688-w4zvfkyl	59	17	]	]	-RRB-
cord-292688-w4zvfkyl	59	18	and	and	CC
cord-292688-w4zvfkyl	59	19	references	reference	NNS
cord-292688-w4zvfkyl	59	20	included	include	VBN
cord-292688-w4zvfkyl	59	21	therein	therein	RB
cord-292688-w4zvfkyl	59	22	)	)	-RRB-
cord-292688-w4zvfkyl	59	23	.	.	.
cord-292688-w4zvfkyl	60	1	Therefore	therefore	RB
cord-292688-w4zvfkyl	60	2	,	,	,
cord-292688-w4zvfkyl	60	3	if	if	IN
cord-292688-w4zvfkyl	60	4	sorting	sorting	NN
cord-292688-w4zvfkyl	60	5	of	of	IN
cord-292688-w4zvfkyl	60	6	regulated	regulated	JJ
cord-292688-w4zvfkyl	60	7	secretory	secretory	JJ
cord-292688-w4zvfkyl	60	8	proteins	protein	NNS
cord-292688-w4zvfkyl	60	9	into	into	IN
cord-292688-w4zvfkyl	60	10	dense	dense	JJ
cord-292688-w4zvfkyl	60	11	cores	core	NNS
cord-292688-w4zvfkyl	60	12	relies	rely	VBZ
cord-292688-w4zvfkyl	60	13	on	on	IN
cord-292688-w4zvfkyl	60	14	exclusion	exclusion	NN
cord-292688-w4zvfkyl	60	15	of	of	IN
cord-292688-w4zvfkyl	60	16	soluble	soluble	JJ
cord-292688-w4zvfkyl	60	17	non	non	JJ
cord-292688-w4zvfkyl	60	18	-	-	JJ
cord-292688-w4zvfkyl	60	19	granule	granule	JJ
cord-292688-w4zvfkyl	60	20	material	material	NN
cord-292688-w4zvfkyl	60	21	through	through	IN
cord-292688-w4zvfkyl	60	22	aggregation	aggregation	NN
cord-292688-w4zvfkyl	60	23	,	,	,
cord-292688-w4zvfkyl	60	24	or	or	CC
cord-292688-w4zvfkyl	60	25	condensation	condensation	NN
cord-292688-w4zvfkyl	60	26	,	,	,
cord-292688-w4zvfkyl	60	27	insulin	insulin	NN
cord-292688-w4zvfkyl	60	28	can	can	MD
cord-292688-w4zvfkyl	60	29	only	only	RB
cord-292688-w4zvfkyl	60	30	be	be	VB
cord-292688-w4zvfkyl	60	31	sorted	sort	VBN
cord-292688-w4zvfkyl	60	32	in	in	IN
cord-292688-w4zvfkyl	60	33	a	a	DT
cord-292688-w4zvfkyl	60	34	post	post	JJ
cord-292688-w4zvfkyl	60	35	-	-	JJ
cord-292688-w4zvfkyl	60	36	TGN	tgn	JJ
cord-292688-w4zvfkyl	60	37	compartment	compartment	NN
cord-292688-w4zvfkyl	60	38	.	.	.
cord-292688-w4zvfkyl	61	1	This	this	DT
cord-292688-w4zvfkyl	61	2	result	result	NN
cord-292688-w4zvfkyl	61	3	also	also	RB
cord-292688-w4zvfkyl	61	4	implies	imply	VBZ
cord-292688-w4zvfkyl	61	5	that	that	IN
cord-292688-w4zvfkyl	61	6	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	61	7	can	can	MD
cord-292688-w4zvfkyl	61	8	not	not	RB
cord-292688-w4zvfkyl	61	9	be	be	VB
cord-292688-w4zvfkyl	61	10	sorted	sort	VBN
cord-292688-w4zvfkyl	61	11	by	by	IN
cord-292688-w4zvfkyl	61	12	aggregation	aggregation	NN
cord-292688-w4zvfkyl	61	13	in	in	IN
cord-292688-w4zvfkyl	61	14	the	the	DT
cord-292688-w4zvfkyl	61	15	TGN	TGN	NNP
cord-292688-w4zvfkyl	61	16	or	or	CC
cord-292688-w4zvfkyl	61	17	any	any	DT
cord-292688-w4zvfkyl	61	18	post	post	JJ
cord-292688-w4zvfkyl	61	19	-	-	JJ
cord-292688-w4zvfkyl	61	20	TGN	tgn	JJ
cord-292688-w4zvfkyl	61	21	compartment	compartment	NN
cord-292688-w4zvfkyl	61	22	.	.	.
cord-292688-w4zvfkyl	62	1	These	these	DT
cord-292688-w4zvfkyl	62	2	results	result	NNS
cord-292688-w4zvfkyl	62	3	have	have	VBP
cord-292688-w4zvfkyl	62	4	provided	provide	VBN
cord-292688-w4zvfkyl	62	5	the	the	DT
cord-292688-w4zvfkyl	62	6	basis	basis	NN
cord-292688-w4zvfkyl	62	7	for	for	IN
cord-292688-w4zvfkyl	62	8	the`sorting	the`sorting	NNP
cord-292688-w4zvfkyl	63	1	by	by	IN
cord-292688-w4zvfkyl	63	2	retention	retention	NN
cord-292688-w4zvfkyl	63	3	'	'	''
cord-292688-w4zvfkyl	63	4	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	63	5	[	[	-LRB-
cord-292688-w4zvfkyl	63	6	26	26	CD
cord-292688-w4zvfkyl	63	7	]	]	-RRB-
cord-292688-w4zvfkyl	64	1	(	(	-LRB-
cord-292688-w4zvfkyl	64	2	Fig	Fig	NNP
cord-292688-w4zvfkyl	64	3	.	.	NNP
cord-292688-w4zvfkyl	64	4	1	1	CD
cord-292688-w4zvfkyl	64	5	)	)	-RRB-
cord-292688-w4zvfkyl	64	6	.	.	.
cord-292688-w4zvfkyl	65	1	This	this	DT
cord-292688-w4zvfkyl	65	2	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	65	3	suggests	suggest	VBZ
cord-292688-w4zvfkyl	65	4	that	that	IN
cord-292688-w4zvfkyl	65	5	regulated	regulate	VBN
cord-292688-w4zvfkyl	65	6	secretory	secretory	JJ
cord-292688-w4zvfkyl	65	7	proteins	protein	NNS
cord-292688-w4zvfkyl	65	8	are	be	VBP
cord-292688-w4zvfkyl	65	9	sorted	sort	VBN
cord-292688-w4zvfkyl	65	10	largely	largely	RB
cord-292688-w4zvfkyl	65	11	by	by	IN
cord-292688-w4zvfkyl	65	12	retention	retention	NN
cord-292688-w4zvfkyl	65	13	in	in	IN
cord-292688-w4zvfkyl	65	14	a	a	DT
cord-292688-w4zvfkyl	65	15	post	post	JJ
cord-292688-w4zvfkyl	65	16	-	-	JJ
cord-292688-w4zvfkyl	65	17	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	65	18	ISG	ISG	NNP
cord-292688-w4zvfkyl	65	19	.	.	.
cord-292688-w4zvfkyl	66	1	Non	non	JJ
cord-292688-w4zvfkyl	66	2	-	-	JJ
cord-292688-w4zvfkyl	66	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	66	4	granule	granule	NN
cord-292688-w4zvfkyl	66	5	proteins	protein	NNS
cord-292688-w4zvfkyl	66	6	,	,	,
cord-292688-w4zvfkyl	66	7	or	or	CC
cord-292688-w4zvfkyl	66	8	processing	process	VBG
cord-292688-w4zvfkyl	66	9	remnants	remnant	NNS
cord-292688-w4zvfkyl	66	10	of	of	IN
cord-292688-w4zvfkyl	66	11	regulated	regulated	JJ
cord-292688-w4zvfkyl	66	12	secretory	secretory	JJ
cord-292688-w4zvfkyl	66	13	proteins	protein	NNS
cord-292688-w4zvfkyl	66	14	,	,	,
cord-292688-w4zvfkyl	66	15	such	such	JJ
cord-292688-w4zvfkyl	66	16	as	as	IN
cord-292688-w4zvfkyl	66	17	the	the	DT
cord-292688-w4zvfkyl	66	18	C	C	NNP
cord-292688-w4zvfkyl	66	19	-	-	HYPH
cord-292688-w4zvfkyl	66	20	peptide	peptide	NN
cord-292688-w4zvfkyl	66	21	(	(	-LRB-
cord-292688-w4zvfkyl	66	22	which	which	WDT
cord-292688-w4zvfkyl	66	23	is	be	VBZ
cord-292688-w4zvfkyl	66	24	derived	derive	VBN
cord-292688-w4zvfkyl	66	25	from	from	IN
cord-292688-w4zvfkyl	66	26	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	66	27	and	and	CC
cord-292688-w4zvfkyl	66	28	not	not	RB
cord-292688-w4zvfkyl	66	29	found	find	VBN
cord-292688-w4zvfkyl	66	30	in	in	IN
cord-292688-w4zvfkyl	66	31	mature	mature	JJ
cord-292688-w4zvfkyl	66	32	insulin	insulin	NN
cord-292688-w4zvfkyl	66	33	)	)	-RRB-
cord-292688-w4zvfkyl	66	34	,	,	,
cord-292688-w4zvfkyl	66	35	can	can	MD
cord-292688-w4zvfkyl	66	36	be	be	VB
cord-292688-w4zvfkyl	66	37	in	in	IN
cord-292688-w4zvfkyl	66	38	part	part	NN
cord-292688-w4zvfkyl	66	39	removed	remove	VBN
cord-292688-w4zvfkyl	66	40	by	by	IN
cord-292688-w4zvfkyl	66	41	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	66	42	-	-	HYPH
cord-292688-w4zvfkyl	66	43	like	like	JJ
cord-292688-w4zvfkyl	66	44	vesicle	vesicle	NN
cord-292688-w4zvfkyl	66	45	budding	bud	VBG
cord-292688-w4zvfkyl	66	46	from	from	IN
cord-292688-w4zvfkyl	66	47	the	the	DT
cord-292688-w4zvfkyl	66	48	ISG	ISG	NNP
cord-292688-w4zvfkyl	66	49	,	,	,
cord-292688-w4zvfkyl	66	50	although	although	IN
cord-292688-w4zvfkyl	66	51	the	the	DT
cord-292688-w4zvfkyl	66	52	e¤ciency	e¤ciency	NN
cord-292688-w4zvfkyl	66	53	of	of	IN
cord-292688-w4zvfkyl	66	54	this	this	DT
cord-292688-w4zvfkyl	66	55	removal	removal	NN
cord-292688-w4zvfkyl	66	56	is	be	VBZ
cord-292688-w4zvfkyl	66	57	likely	likely	JJ
cord-292688-w4zvfkyl	66	58	to	to	TO
cord-292688-w4zvfkyl	66	59	be	be	VB
cord-292688-w4zvfkyl	66	60	related	relate	VBN
cord-292688-w4zvfkyl	66	61	to	to	IN
cord-292688-w4zvfkyl	66	62	whether	whether	IN
cord-292688-w4zvfkyl	66	63	a	a	DT
cord-292688-w4zvfkyl	66	64	selection	selection	NN
cord-292688-w4zvfkyl	66	65	process	process	NN
cord-292688-w4zvfkyl	66	66	(	(	-LRB-
cord-292688-w4zvfkyl	66	67	i.e.	i.e.	FW
cord-292688-w4zvfkyl	66	68	receptor	receptor	NN
cord-292688-w4zvfkyl	66	69	-	-	HYPH
cord-292688-w4zvfkyl	66	70	mediated	mediate	VBN
cord-292688-w4zvfkyl	66	71	)	)	-RRB-
cord-292688-w4zvfkyl	66	72	process	process	NN
cord-292688-w4zvfkyl	66	73	is	be	VBZ
cord-292688-w4zvfkyl	66	74	employed	employ	VBN
cord-292688-w4zvfkyl	66	75	.	.	.
cord-292688-w4zvfkyl	67	1	Thus	thus	RB
cord-292688-w4zvfkyl	67	2	,	,	,
cord-292688-w4zvfkyl	67	3	the	the	DT
cord-292688-w4zvfkyl	67	4	e¤ciency	e¤ciency	NN
cord-292688-w4zvfkyl	67	5	for	for	IN
cord-292688-w4zvfkyl	67	6	removal	removal	NN
cord-292688-w4zvfkyl	67	7	from	from	IN
cord-292688-w4zvfkyl	67	8	ISGs	isg	NNS
cord-292688-w4zvfkyl	67	9	might	may	MD
cord-292688-w4zvfkyl	67	10	be	be	VB
cord-292688-w4zvfkyl	67	11	expected	expect	VBN
cord-292688-w4zvfkyl	67	12	to	to	TO
cord-292688-w4zvfkyl	67	13	vary	vary	VB
cord-292688-w4zvfkyl	67	14	for	for	IN
cord-292688-w4zvfkyl	67	15	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	67	16	proteins	protein	NNS
cord-292688-w4zvfkyl	67	17	(	(	-LRB-
cord-292688-w4zvfkyl	67	18	see	see	VB
cord-292688-w4zvfkyl	67	19	below	below	RB
cord-292688-w4zvfkyl	67	20	)	)	-RRB-
cord-292688-w4zvfkyl	67	21	.	.	.
cord-292688-w4zvfkyl	68	1	An	an	DT
cord-292688-w4zvfkyl	68	2	interesting	interesting	JJ
cord-292688-w4zvfkyl	68	3	example	example	NN
cord-292688-w4zvfkyl	68	4	which	which	WDT
cord-292688-w4zvfkyl	68	5	reinforces	reinforce	VBZ
cord-292688-w4zvfkyl	68	6	the	the	DT
cord-292688-w4zvfkyl	68	7	importance	importance	NN
cord-292688-w4zvfkyl	68	8	of	of	IN
cord-292688-w4zvfkyl	68	9	the	the	DT
cord-292688-w4zvfkyl	68	10	precise	precise	JJ
cord-292688-w4zvfkyl	68	11	location	location	NN
cord-292688-w4zvfkyl	68	12	of	of	IN
cord-292688-w4zvfkyl	68	13	prohormone	prohormone	NN
cord-292688-w4zvfkyl	68	14	processing	processing	NN
cord-292688-w4zvfkyl	68	15	on	on	IN
cord-292688-w4zvfkyl	68	16	sorting	sorting	NN
cord-292688-w4zvfkyl	68	17	comes	come	VBZ
cord-292688-w4zvfkyl	68	18	from	from	IN
cord-292688-w4zvfkyl	68	19	experiments	experiment	NNS
cord-292688-w4zvfkyl	68	20	done	do	VBN
cord-292688-w4zvfkyl	68	21	on	on	IN
cord-292688-w4zvfkyl	68	22	Aplysia	Aplysia	NNP
cord-292688-w4zvfkyl	68	23	californica	californica	NN
cord-292688-w4zvfkyl	68	24	[	[	-LRB-
cord-292688-w4zvfkyl	68	25	27	27	CD
cord-292688-w4zvfkyl	68	26	]	]	-RRB-
cord-292688-w4zvfkyl	68	27	and	and	CC
cord-292688-w4zvfkyl	68	28	Lymnaea	Lymnaea	NNP
cord-292688-w4zvfkyl	68	29	stagnalis	stagnalis	NNP
cord-292688-w4zvfkyl	68	30	[	[	-LRB-
cord-292688-w4zvfkyl	68	31	28	28	CD
cord-292688-w4zvfkyl	68	32	]	]	-RRB-
cord-292688-w4zvfkyl	68	33	.	.	.
cord-292688-w4zvfkyl	69	1	These	these	DT
cord-292688-w4zvfkyl	69	2	two	two	CD
cord-292688-w4zvfkyl	69	3	model	model	NN
cord-292688-w4zvfkyl	69	4	systems	system	NNS
cord-292688-w4zvfkyl	69	5	have	have	VBP
cord-292688-w4zvfkyl	69	6	been	be	VBN
cord-292688-w4zvfkyl	69	7	used	use	VBN
cord-292688-w4zvfkyl	69	8	to	to	TO
cord-292688-w4zvfkyl	69	9	demonstrate	demonstrate	VB
cord-292688-w4zvfkyl	69	10	that	that	DT
cord-292688-w4zvfkyl	69	11	sorting	sorting	NN
cord-292688-w4zvfkyl	69	12	of	of	IN
cord-292688-w4zvfkyl	69	13	proELH	proelh	NN
cord-292688-w4zvfkyl	69	14	(	(	-LRB-
cord-292688-w4zvfkyl	69	15	egg	egg	NN
cord-292688-w4zvfkyl	69	16	-	-	HYPH
cord-292688-w4zvfkyl	69	17	laying	lay	VBG
cord-292688-w4zvfkyl	69	18	hormone	hormone	NN
cord-292688-w4zvfkyl	69	19	)	)	-RRB-
cord-292688-w4zvfkyl	69	20	can	can	MD
cord-292688-w4zvfkyl	69	21	be	be	VB
cord-292688-w4zvfkyl	69	22	in£uenced	in£uence	VBN
cord-292688-w4zvfkyl	69	23	by	by	IN
cord-292688-w4zvfkyl	69	24	the	the	DT
cord-292688-w4zvfkyl	69	25	location	location	NN
cord-292688-w4zvfkyl	69	26	of	of	IN
cord-292688-w4zvfkyl	69	27	cleavage	cleavage	NN
cord-292688-w4zvfkyl	69	28	,	,	,
cord-292688-w4zvfkyl	69	29	which	which	WDT
cord-292688-w4zvfkyl	69	30	in	in	IN
cord-292688-w4zvfkyl	69	31	turn	turn	NN
cord-292688-w4zvfkyl	69	32	presumably	presumably	RB
cord-292688-w4zvfkyl	69	33	a¡ects	a¡ect	VBZ
cord-292688-w4zvfkyl	69	34	the	the	DT
cord-292688-w4zvfkyl	69	35	hormones	hormone	NNS
cord-292688-w4zvfkyl	69	36	ability	ability	NN
cord-292688-w4zvfkyl	69	37	to	to	TO
cord-292688-w4zvfkyl	69	38	aggregate	aggregate	VB
cord-292688-w4zvfkyl	69	39	or	or	CC
cord-292688-w4zvfkyl	69	40	condense	condense	VB
cord-292688-w4zvfkyl	69	41	.	.	.
cord-292688-w4zvfkyl	70	1	In	in	IN
cord-292688-w4zvfkyl	70	2	Aplysia	Aplysia	NNP
cord-292688-w4zvfkyl	70	3	,	,	,
cord-292688-w4zvfkyl	70	4	the	the	DT
cord-292688-w4zvfkyl	70	5	proELH	proelh	NN
cord-292688-w4zvfkyl	70	6	is	be	VBZ
cord-292688-w4zvfkyl	70	7	cleaved	cleave	VBN
cord-292688-w4zvfkyl	70	8	in	in	IN
cord-292688-w4zvfkyl	70	9	the	the	DT
cord-292688-w4zvfkyl	70	10	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	70	11	and	and	CC
cord-292688-w4zvfkyl	70	12	the	the	DT
cord-292688-w4zvfkyl	70	13	two	two	CD
cord-292688-w4zvfkyl	70	14	N	n	CD
cord-292688-w4zvfkyl	70	15	-	-	HYPH
cord-292688-w4zvfkyl	70	16	terminal	terminal	NN
cord-292688-w4zvfkyl	70	17	and	and	CC
cord-292688-w4zvfkyl	70	18	C	c	NN
cord-292688-w4zvfkyl	70	19	-	-	HYPH
cord-292688-w4zvfkyl	70	20	terminal	terminal	NN
cord-292688-w4zvfkyl	70	21	intermediates	intermediate	NNS
cord-292688-w4zvfkyl	70	22	are	be	VBP
cord-292688-w4zvfkyl	70	23	sorted	sort	VBN
cord-292688-w4zvfkyl	70	24	into	into	IN
cord-292688-w4zvfkyl	70	25	two	two	CD
cord-292688-w4zvfkyl	70	26	distinct	distinct	JJ
cord-292688-w4zvfkyl	70	27	populations	population	NNS
cord-292688-w4zvfkyl	70	28	of	of	IN
cord-292688-w4zvfkyl	70	29	large	large	JJ
cord-292688-w4zvfkyl	70	30	dense	dense	JJ
cord-292688-w4zvfkyl	70	31	core	core	NN
cord-292688-w4zvfkyl	70	32	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	70	33	(	(	-LRB-
cord-292688-w4zvfkyl	70	34	LDCVs	ldcv	NNS
cord-292688-w4zvfkyl	70	35	)	)	-RRB-
cord-292688-w4zvfkyl	70	36	[	[	-LRB-
cord-292688-w4zvfkyl	70	37	27	27	CD
cord-292688-w4zvfkyl	70	38	]	]	-RRB-
cord-292688-w4zvfkyl	70	39	.	.	.
cord-292688-w4zvfkyl	71	1	Lymnaea	Lymnaea	NNP
cord-292688-w4zvfkyl	71	2	presents	present	VBZ
cord-292688-w4zvfkyl	71	3	a	a	DT
cord-292688-w4zvfkyl	71	4	more	more	RBR
cord-292688-w4zvfkyl	71	5	complicated	complicated	JJ
cord-292688-w4zvfkyl	71	6	scenario	scenario	NN
cord-292688-w4zvfkyl	71	7	in	in	IN
cord-292688-w4zvfkyl	71	8	that	that	IN
cord-292688-w4zvfkyl	71	9	there	there	EX
cord-292688-w4zvfkyl	71	10	are	be	VBP
cord-292688-w4zvfkyl	72	1	two	two	CD
cord-292688-w4zvfkyl	72	2	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	72	3	types	type	NNS
cord-292688-w4zvfkyl	72	4	of	of	IN
cord-292688-w4zvfkyl	72	5	neurones	neurone	NNS
cord-292688-w4zvfkyl	72	6	which	which	WDT
cord-292688-w4zvfkyl	72	7	produce	produce	VBP
cord-292688-w4zvfkyl	72	8	ELH	ELH	NNP
cord-292688-w4zvfkyl	72	9	:	:	:
cord-292688-w4zvfkyl	72	10	in	in	IN
cord-292688-w4zvfkyl	72	11	one	one	CD
cord-292688-w4zvfkyl	72	12	type	type	NN
cord-292688-w4zvfkyl	72	13	(	(	-LRB-
cord-292688-w4zvfkyl	72	14	type	type	NN
cord-292688-w4zvfkyl	72	15	I	-PRON-	PRP
cord-292688-w4zvfkyl	72	16	neurones	neurone	NNS
cord-292688-w4zvfkyl	72	17	)	)	-RRB-
cord-292688-w4zvfkyl	72	18	processing	processing	NN
cord-292688-w4zvfkyl	72	19	occurs	occur	VBZ
cord-292688-w4zvfkyl	72	20	in	in	IN
cord-292688-w4zvfkyl	72	21	the	the	DT
cord-292688-w4zvfkyl	72	22	TGN	TGN	NNP
cord-292688-w4zvfkyl	72	23	and	and	CC
cord-292688-w4zvfkyl	72	24	results	result	NNS
cord-292688-w4zvfkyl	72	25	in	in	IN
cord-292688-w4zvfkyl	72	26	the	the	DT
cord-292688-w4zvfkyl	72	27	appearance	appearance	NN
cord-292688-w4zvfkyl	72	28	of	of	IN
cord-292688-w4zvfkyl	72	29	two	two	CD
cord-292688-w4zvfkyl	72	30	morphologically	morphologically	RB
cord-292688-w4zvfkyl	72	31	distinguishable	distinguishable	JJ
cord-292688-w4zvfkyl	72	32	condensed	condense	VBN
cord-292688-w4zvfkyl	72	33	protein	protein	NN
cord-292688-w4zvfkyl	72	34	cores	core	NNS
cord-292688-w4zvfkyl	72	35	,	,	,
cord-292688-w4zvfkyl	72	36	containing	contain	VBG
cord-292688-w4zvfkyl	72	37	either	either	CC
cord-292688-w4zvfkyl	72	38	the	the	DT
cord-292688-w4zvfkyl	72	39	N	n	CD
cord-292688-w4zvfkyl	72	40	-	-	HYPH
cord-292688-w4zvfkyl	72	41	terminal	terminal	NN
cord-292688-w4zvfkyl	72	42	or	or	CC
cord-292688-w4zvfkyl	72	43	C	c	NN
cord-292688-w4zvfkyl	72	44	-	-	HYPH
cord-292688-w4zvfkyl	72	45	terminal	terminal	NN
cord-292688-w4zvfkyl	72	46	region	region	NN
cord-292688-w4zvfkyl	72	47	of	of	IN
cord-292688-w4zvfkyl	72	48	ELH	ELH	NNP
cord-292688-w4zvfkyl	72	49	,	,	,
cord-292688-w4zvfkyl	72	50	which	which	WDT
cord-292688-w4zvfkyl	72	51	are	be	VBP
cord-292688-w4zvfkyl	72	52	sorted	sort	VBN
cord-292688-w4zvfkyl	72	53	to	to	IN
cord-292688-w4zvfkyl	72	54	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	72	55	populations	population	NNS
cord-292688-w4zvfkyl	72	56	of	of	IN
cord-292688-w4zvfkyl	72	57	secretory	secretory	JJ
cord-292688-w4zvfkyl	72	58	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	72	59	,	,	,
cord-292688-w4zvfkyl	72	60	LEG	leg	NN
cord-292688-w4zvfkyl	72	61	(	(	-LRB-
cord-292688-w4zvfkyl	72	62	large	large	JJ
cord-292688-w4zvfkyl	72	63	electrondense	electrondense	NN
cord-292688-w4zvfkyl	72	64	granule	granule	NN
cord-292688-w4zvfkyl	72	65	)	)	-RRB-
cord-292688-w4zvfkyl	72	66	and	and	CC
cord-292688-w4zvfkyl	72	67	LDCVs	ldcv	NNS
cord-292688-w4zvfkyl	72	68	[	[	-LRB-
cord-292688-w4zvfkyl	72	69	28	28	CD
cord-292688-w4zvfkyl	72	70	]	]	-RRB-
cord-292688-w4zvfkyl	72	71	.	.	.
cord-292688-w4zvfkyl	73	1	In	in	IN
cord-292688-w4zvfkyl	73	2	the	the	DT
cord-292688-w4zvfkyl	73	3	second	second	JJ
cord-292688-w4zvfkyl	73	4	type	type	NN
cord-292688-w4zvfkyl	73	5	of	of	IN
cord-292688-w4zvfkyl	73	6	neurone	neurone	NN
cord-292688-w4zvfkyl	73	7	(	(	-LRB-
cord-292688-w4zvfkyl	73	8	type	type	NN
cord-292688-w4zvfkyl	73	9	II	II	NNP
cord-292688-w4zvfkyl	73	10	)	)	-RRB-
cord-292688-w4zvfkyl	73	11	,	,	,
cord-292688-w4zvfkyl	73	12	the	the	DT
cord-292688-w4zvfkyl	73	13	ELH	ELH	NNP
cord-292688-w4zvfkyl	73	14	is	be	VBZ
cord-292688-w4zvfkyl	73	15	not	not	RB
cord-292688-w4zvfkyl	73	16	cleaved	cleave	VBN
cord-292688-w4zvfkyl	73	17	in	in	IN
cord-292688-w4zvfkyl	73	18	the	the	DT
cord-292688-w4zvfkyl	73	19	TGN	TGN	NNP
cord-292688-w4zvfkyl	73	20	and	and	CC
cord-292688-w4zvfkyl	73	21	is	be	VBZ
cord-292688-w4zvfkyl	73	22	sorted	sort	VBN
cord-292688-w4zvfkyl	73	23	into	into	IN
cord-292688-w4zvfkyl	73	24	the	the	DT
cord-292688-w4zvfkyl	73	25	LDCVs	ldcv	NNS
cord-292688-w4zvfkyl	73	26	as	as	IN
cord-292688-w4zvfkyl	73	27	a	a	DT
cord-292688-w4zvfkyl	73	28	prohormone	prohormone	NN
cord-292688-w4zvfkyl	73	29	,	,	,
cord-292688-w4zvfkyl	73	30	after	after	IN
cord-292688-w4zvfkyl	73	31	which	which	WDT
cord-292688-w4zvfkyl	73	32	it	-PRON-	PRP
cord-292688-w4zvfkyl	73	33	undergoes	undergo	VBZ
cord-292688-w4zvfkyl	73	34	cleavage	cleavage	NN
cord-292688-w4zvfkyl	73	35	to	to	TO
cord-292688-w4zvfkyl	73	36	mature	mature	VB
cord-292688-w4zvfkyl	73	37	ELH	ELH	NNP
cord-292688-w4zvfkyl	73	38	.	.	.
cord-292688-w4zvfkyl	74	1	This	this	DT
cord-292688-w4zvfkyl	74	2	raises	raise	VBZ
cord-292688-w4zvfkyl	74	3	an	an	DT
cord-292688-w4zvfkyl	74	4	interesting	interesting	JJ
cord-292688-w4zvfkyl	74	5	question	question	NN
cord-292688-w4zvfkyl	74	6	concerning	concern	VBG
cord-292688-w4zvfkyl	74	7	how	how	WRB
cord-292688-w4zvfkyl	74	8	proteins	protein	NNS
cord-292688-w4zvfkyl	74	9	exit	exit	NN
cord-292688-w4zvfkyl	74	10	from	from	IN
cord-292688-w4zvfkyl	74	11	the	the	DT
cord-292688-w4zvfkyl	74	12	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	74	13	in	in	IN
cord-292688-w4zvfkyl	74	14	type	type	NN
cord-292688-w4zvfkyl	74	15	I	-PRON-	PRP
cord-292688-w4zvfkyl	74	16	and	and	CC
cord-292688-w4zvfkyl	74	17	type	type	NN
cord-292688-w4zvfkyl	74	18	II	II	NNP
cord-292688-w4zvfkyl	74	19	neurones	neurone	NNS
cord-292688-w4zvfkyl	74	20	.	.	.
cord-292688-w4zvfkyl	75	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	75	2	would	would	MD
cord-292688-w4zvfkyl	75	3	be	be	VB
cord-292688-w4zvfkyl	75	4	of	of	IN
cord-292688-w4zvfkyl	75	5	great	great	JJ
cord-292688-w4zvfkyl	75	6	interest	interest	NN
cord-292688-w4zvfkyl	75	7	to	to	TO
cord-292688-w4zvfkyl	75	8	compare	compare	VB
cord-292688-w4zvfkyl	75	9	the	the	DT
cord-292688-w4zvfkyl	75	10	sorting	sorting	NN
cord-292688-w4zvfkyl	75	11	of	of	IN
cord-292688-w4zvfkyl	75	12	true`constitutive	true`constitutive	NNP
cord-292688-w4zvfkyl	75	13	'	'	POS
cord-292688-w4zvfkyl	75	14	proteins	protein	NNS
cord-292688-w4zvfkyl	75	15	in	in	IN
cord-292688-w4zvfkyl	75	16	type	type	NN
cord-292688-w4zvfkyl	75	17	I	-PRON-	PRP
cord-292688-w4zvfkyl	75	18	and	and	CC
cord-292688-w4zvfkyl	75	19	type	type	NN
cord-292688-w4zvfkyl	75	20	II	II	NNP
cord-292688-w4zvfkyl	75	21	neurones	neurone	NNS
cord-292688-w4zvfkyl	75	22	to	to	TO
cord-292688-w4zvfkyl	75	23	see	see	VB
cord-292688-w4zvfkyl	75	24	if	if	IN
cord-292688-w4zvfkyl	75	25	in	in	IN
cord-292688-w4zvfkyl	75	26	type	type	NN
cord-292688-w4zvfkyl	75	27	I	-PRON-	PRP
cord-292688-w4zvfkyl	75	28	neurones	neurone	NNS
cord-292688-w4zvfkyl	75	29	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	75	30	secretory	secretory	JJ
cord-292688-w4zvfkyl	75	31	proteins	protein	NNS
cord-292688-w4zvfkyl	75	32	are	be	VBP
cord-292688-w4zvfkyl	75	33	secreted	secrete	VBN
cord-292688-w4zvfkyl	75	34	constitutively	constitutively	RB
cord-292688-w4zvfkyl	75	35	,	,	,
cord-292688-w4zvfkyl	75	36	implying	imply	VBG
cord-292688-w4zvfkyl	75	37	that	that	IN
cord-292688-w4zvfkyl	75	38	CSVs	csv	NNS
cord-292688-w4zvfkyl	75	39	are	be	VBP
cord-292688-w4zvfkyl	75	40	formed	form	VBN
cord-292688-w4zvfkyl	75	41	directly	directly	RB
cord-292688-w4zvfkyl	75	42	from	from	IN
cord-292688-w4zvfkyl	75	43	the	the	DT
cord-292688-w4zvfkyl	75	44	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	75	45	,	,	,
cord-292688-w4zvfkyl	75	46	and	and	CC
cord-292688-w4zvfkyl	75	47	likewise	likewise	RB
cord-292688-w4zvfkyl	75	48	if	if	IN
cord-292688-w4zvfkyl	75	49	in	in	IN
cord-292688-w4zvfkyl	75	50	type	type	NN
cord-292688-w4zvfkyl	75	51	II	II	NNP
cord-292688-w4zvfkyl	75	52	neurones	neurone	NNS
cord-292688-w4zvfkyl	75	53	if	if	IN
cord-292688-w4zvfkyl	75	54	these	these	DT
cord-292688-w4zvfkyl	75	55	proteins	protein	NNS
cord-292688-w4zvfkyl	75	56	are	be	VBP
cord-292688-w4zvfkyl	75	57	secreted	secrete	VBN
cord-292688-w4zvfkyl	75	58	in	in	IN
cord-292688-w4zvfkyl	75	59	a	a	DT
cord-292688-w4zvfkyl	75	60	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	75	61	-	-	HYPH
cord-292688-w4zvfkyl	75	62	like	like	JJ
cord-292688-w4zvfkyl	75	63	fashion	fashion	NN
cord-292688-w4zvfkyl	75	64	,	,	,
cord-292688-w4zvfkyl	75	65	implying	imply	VBG
cord-292688-w4zvfkyl	75	66	secretion	secretion	NN
cord-292688-w4zvfkyl	75	67	originates	originate	VBZ
cord-292688-w4zvfkyl	75	68	from	from	IN
cord-292688-w4zvfkyl	75	69	ISGs	isg	NNS
cord-292688-w4zvfkyl	75	70	.	.	.
cord-292688-w4zvfkyl	76	1	Interestingly	interestingly	RB
cord-292688-w4zvfkyl	76	2	,	,	,
cord-292688-w4zvfkyl	76	3	the	the	DT
cord-292688-w4zvfkyl	76	4	LDCVs	ldcv	NNS
cord-292688-w4zvfkyl	76	5	from	from	IN
cord-292688-w4zvfkyl	76	6	the	the	DT
cord-292688-w4zvfkyl	76	7	two	two	CD
cord-292688-w4zvfkyl	76	8	types	type	NNS
cord-292688-w4zvfkyl	76	9	of	of	IN
cord-292688-w4zvfkyl	76	10	neurones	neurones	NNP
cord-292688-w4zvfkyl	76	11	di¡er	di¡er	NNP
cord-292688-w4zvfkyl	76	12	in	in	IN
cord-292688-w4zvfkyl	76	13	size	size	NN
cord-292688-w4zvfkyl	76	14	,	,	,
cord-292688-w4zvfkyl	76	15	the	the	DT
cord-292688-w4zvfkyl	76	16	LDCV	LDCV	NNP
cord-292688-w4zvfkyl	76	17	from	from	IN
cord-292688-w4zvfkyl	76	18	the	the	DT
cord-292688-w4zvfkyl	76	19	type	type	NN
cord-292688-w4zvfkyl	76	20	I	-PRON-	PRP
cord-292688-w4zvfkyl	76	21	neurone	neurone	NN
cord-292688-w4zvfkyl	76	22	having	have	VBG
cord-292688-w4zvfkyl	76	23	a	a	DT
cord-292688-w4zvfkyl	76	24	size	size	NN
cord-292688-w4zvfkyl	76	25	of	of	IN
cord-292688-w4zvfkyl	76	26	approximately	approximately	RB
cord-292688-w4zvfkyl	76	27	150	150	CD
cord-292688-w4zvfkyl	76	28	nm	nm	NN
cord-292688-w4zvfkyl	76	29	whereas	whereas	IN
cord-292688-w4zvfkyl	76	30	the	the	DT
cord-292688-w4zvfkyl	76	31	LDCVs	ldcv	NNS
cord-292688-w4zvfkyl	76	32	in	in	IN
cord-292688-w4zvfkyl	76	33	the	the	DT
cord-292688-w4zvfkyl	76	34	type	type	NN
cord-292688-w4zvfkyl	76	35	II	II	NNP
cord-292688-w4zvfkyl	76	36	neurone	neurone	NN
cord-292688-w4zvfkyl	76	37	was	be	VBD
cord-292688-w4zvfkyl	76	38	90	90	CD
cord-292688-w4zvfkyl	76	39	nm	nm	CD
cord-292688-w4zvfkyl	76	40	[	[	-LRB-
cord-292688-w4zvfkyl	76	41	28	28	CD
cord-292688-w4zvfkyl	76	42	]	]	-RRB-
cord-292688-w4zvfkyl	76	43	suggesting	suggest	VBG
cord-292688-w4zvfkyl	76	44	that	that	IN
cord-292688-w4zvfkyl	76	45	the	the	DT
cord-292688-w4zvfkyl	76	46	composition	composition	NN
cord-292688-w4zvfkyl	76	47	of	of	IN
cord-292688-w4zvfkyl	76	48	the	the	DT
cord-292688-w4zvfkyl	76	49	content	content	NN
cord-292688-w4zvfkyl	76	50	has	have	VBZ
cord-292688-w4zvfkyl	76	51	an	an	DT
cord-292688-w4zvfkyl	76	52	in£uence	in£uence	NNP
cord-292688-w4zvfkyl	76	53	6	6	CD
cord-292688-w4zvfkyl	76	54	Fig	fig	NN
cord-292688-w4zvfkyl	76	55	.	.	NN
cord-292688-w4zvfkyl	76	56	1	1	CD
cord-292688-w4zvfkyl	76	57	.	.	.
cord-292688-w4zvfkyl	77	1	Depicted	depict	VBN
cord-292688-w4zvfkyl	77	2	in	in	IN
cord-292688-w4zvfkyl	77	3	a	a	DT
cord-292688-w4zvfkyl	77	4	very	very	RB
cord-292688-w4zvfkyl	77	5	simple	simple	JJ
cord-292688-w4zvfkyl	77	6	fashion	fashion	NN
cord-292688-w4zvfkyl	77	7	is	be	VBZ
cord-292688-w4zvfkyl	77	8	a	a	DT
cord-292688-w4zvfkyl	77	9	scheme	scheme	NN
cord-292688-w4zvfkyl	77	10	of	of	IN
cord-292688-w4zvfkyl	77	11	the	the	DT
cord-292688-w4zvfkyl	77	12	sorting	sorting	NN
cord-292688-w4zvfkyl	77	13	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	77	14	in	in	IN
cord-292688-w4zvfkyl	77	15	the	the	DT
cord-292688-w4zvfkyl	77	16	secretory	secretory	JJ
cord-292688-w4zvfkyl	77	17	pathway	pathway	NN
cord-292688-w4zvfkyl	77	18	of	of	IN
cord-292688-w4zvfkyl	77	19	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	77	20	and	and	CC
cord-292688-w4zvfkyl	77	21	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	77	22	cells	cell	NNS
cord-292688-w4zvfkyl	77	23	proposed	propose	VBN
cord-292688-w4zvfkyl	77	24	by	by	IN
cord-292688-w4zvfkyl	77	25	Arvan	Arvan	NNP
cord-292688-w4zvfkyl	77	26	and	and	CC
cord-292688-w4zvfkyl	77	27	colleagues	colleague	NNS
cord-292688-w4zvfkyl	77	28	[	[	-LRB-
cord-292688-w4zvfkyl	77	29	26	26	CD
cord-292688-w4zvfkyl	77	30	]	]	-RRB-
cord-292688-w4zvfkyl	77	31	to	to	TO
cord-292688-w4zvfkyl	77	32	explain	explain	VB
cord-292688-w4zvfkyl	77	33	the	the	DT
cord-292688-w4zvfkyl	77	34	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	77	35	models	model	NNS
cord-292688-w4zvfkyl	77	36	for	for	IN
cord-292688-w4zvfkyl	77	37	formation	formation	NN
cord-292688-w4zvfkyl	77	38	of	of	IN
cord-292688-w4zvfkyl	77	39	regulated	regulate	VBN
cord-292688-w4zvfkyl	77	40	secretory	secretory	JJ
cord-292688-w4zvfkyl	77	41	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	77	42	from	from	IN
cord-292688-w4zvfkyl	77	43	the	the	DT
cord-292688-w4zvfkyl	77	44	TGN	TGN	NNP
cord-292688-w4zvfkyl	77	45	,	,	,
cord-292688-w4zvfkyl	77	46	i.e.	i.e.	FW
cord-292688-w4zvfkyl	77	47	sorting	sort	VBG
cord-292688-w4zvfkyl	77	48	for	for	IN
cord-292688-w4zvfkyl	77	49	entry	entry	NN
cord-292688-w4zvfkyl	77	50	vs.	vs.	FW
cord-292688-w4zvfkyl	77	51	sorting	sorting	NN
cord-292688-w4zvfkyl	77	52	by	by	IN
cord-292688-w4zvfkyl	77	53	retention	retention	NN
cord-292688-w4zvfkyl	77	54	.	.	.
cord-292688-w4zvfkyl	78	1	Also	also	RB
cord-292688-w4zvfkyl	78	2	included	include	VBN
cord-292688-w4zvfkyl	78	3	are	be	VBP
cord-292688-w4zvfkyl	78	4	other	other	JJ
cord-292688-w4zvfkyl	78	5	vesicle	vesicle	NN
cord-292688-w4zvfkyl	78	6	classes	class	NNS
cord-292688-w4zvfkyl	78	7	,	,	,
cord-292688-w4zvfkyl	78	8	such	such	JJ
cord-292688-w4zvfkyl	78	9	as	as	IN
cord-292688-w4zvfkyl	78	10	CSVs	csv	NNS
cord-292688-w4zvfkyl	78	11	and	and	CC
cord-292688-w4zvfkyl	78	12	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	78	13	-	-	HYPH
cord-292688-w4zvfkyl	78	14	like	like	JJ
cord-292688-w4zvfkyl	78	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	78	16	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	78	17	,	,	,
cord-292688-w4zvfkyl	78	18	as	as	RB
cord-292688-w4zvfkyl	78	19	well	well	RB
cord-292688-w4zvfkyl	78	20	as	as	IN
cord-292688-w4zvfkyl	78	21	a	a	DT
cord-292688-w4zvfkyl	78	22	pathway	pathway	NN
cord-292688-w4zvfkyl	78	23	for	for	IN
cord-292688-w4zvfkyl	78	24	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	78	25	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	78	26	(	(	-LRB-
cord-292688-w4zvfkyl	78	27	blue	blue	JJ
cord-292688-w4zvfkyl	78	28	circle	circle	NN
cord-292688-w4zvfkyl	78	29	)	)	-RRB-
cord-292688-w4zvfkyl	78	30	and	and	CC
cord-292688-w4zvfkyl	78	31	MPR	MPR	NNP
cord-292688-w4zvfkyl	78	32	(	(	-LRB-
cord-292688-w4zvfkyl	78	33	black	black	JJ
cord-292688-w4zvfkyl	78	34	cup	cup	NN
cord-292688-w4zvfkyl	78	35	-	-	HYPH
cord-292688-w4zvfkyl	78	36	shaped	shape	VBN
cord-292688-w4zvfkyl	78	37	object	object	NN
cord-292688-w4zvfkyl	78	38	)	)	-RRB-
cord-292688-w4zvfkyl	78	39	.	.	.
cord-292688-w4zvfkyl	79	1	The	the	DT
cord-292688-w4zvfkyl	79	2	low	low	JJ
cord-292688-w4zvfkyl	79	3	amount	amount	NN
cord-292688-w4zvfkyl	79	4	of	of	IN
cord-292688-w4zvfkyl	79	5	missorted	missorted	JJ
cord-292688-w4zvfkyl	79	6	proteins	protein	NNS
cord-292688-w4zvfkyl	79	7	,	,	,
cord-292688-w4zvfkyl	79	8	such	such	JJ
cord-292688-w4zvfkyl	79	9	as	as	IN
cord-292688-w4zvfkyl	79	10	furin	furin	NN
cord-292688-w4zvfkyl	79	11	[	[	-LRB-
cord-292688-w4zvfkyl	79	12	62	62	CD
cord-292688-w4zvfkyl	79	13	]	]	-RRB-
cord-292688-w4zvfkyl	79	14	,	,	,
cord-292688-w4zvfkyl	79	15	and	and	CC
cord-292688-w4zvfkyl	79	16	MPR	MPR	NNP
cord-292688-w4zvfkyl	79	17	found	find	VBD
cord-292688-w4zvfkyl	79	18	in	in	IN
cord-292688-w4zvfkyl	79	19	the	the	DT
cord-292688-w4zvfkyl	79	20	ISG	ISG	NNP
cord-292688-w4zvfkyl	79	21	in	in	IN
cord-292688-w4zvfkyl	79	22	the	the	DT
cord-292688-w4zvfkyl	79	23	top	top	JJ
cord-292688-w4zvfkyl	79	24	panel	panel	NN
cord-292688-w4zvfkyl	79	25	have	have	VBP
cord-292688-w4zvfkyl	79	26	not	not	RB
cord-292688-w4zvfkyl	79	27	been	be	VBN
cord-292688-w4zvfkyl	79	28	illustrated	illustrate	VBN
cord-292688-w4zvfkyl	79	29	for	for	IN
cord-292688-w4zvfkyl	79	30	simplicity	simplicity	NN
cord-292688-w4zvfkyl	79	31	.	.	.
cord-292688-w4zvfkyl	80	1	The	the	DT
cord-292688-w4zvfkyl	80	2	regulated	regulated	JJ
cord-292688-w4zvfkyl	80	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	80	4	proteins	protein	NNS
cord-292688-w4zvfkyl	80	5	are	be	VBP
cord-292688-w4zvfkyl	80	6	shown	show	VBN
cord-292688-w4zvfkyl	80	7	as	as	IN
cord-292688-w4zvfkyl	80	8	yellow	yellow	JJ
cord-292688-w4zvfkyl	80	9	circles	circle	NNS
cord-292688-w4zvfkyl	80	10	,	,	,
cord-292688-w4zvfkyl	80	11	and	and	CC
cord-292688-w4zvfkyl	80	12	the	the	DT
cord-292688-w4zvfkyl	80	13	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	80	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	80	15	proteins	protein	NNS
cord-292688-w4zvfkyl	80	16	are	be	VBP
cord-292688-w4zvfkyl	80	17	shown	show	VBN
cord-292688-w4zvfkyl	80	18	as	as	IN
cord-292688-w4zvfkyl	80	19	red	red	JJ
cord-292688-w4zvfkyl	80	20	circles	circle	NNS
cord-292688-w4zvfkyl	80	21	.	.	.
cord-292688-w4zvfkyl	81	1	For	for	IN
cord-292688-w4zvfkyl	81	2	simplicity	simplicity	NN
cord-292688-w4zvfkyl	81	3	,	,	,
cord-292688-w4zvfkyl	81	4	all	all	DT
cord-292688-w4zvfkyl	81	5	coats	coat	NNS
cord-292688-w4zvfkyl	81	6	and	and	CC
cord-292688-w4zvfkyl	81	7	coat	coat	NN
cord-292688-w4zvfkyl	81	8	proteins	protein	NNS
cord-292688-w4zvfkyl	81	9	have	have	VBP
cord-292688-w4zvfkyl	81	10	been	be	VBN
cord-292688-w4zvfkyl	81	11	omitted	omit	VBN
cord-292688-w4zvfkyl	81	12	,	,	,
cord-292688-w4zvfkyl	81	13	as	as	RB
cord-292688-w4zvfkyl	81	14	well	well	RB
cord-292688-w4zvfkyl	81	15	as	as	IN
cord-292688-w4zvfkyl	81	16	any	any	DT
cord-292688-w4zvfkyl	81	17	putative	putative	JJ
cord-292688-w4zvfkyl	81	18	interactions	interaction	NNS
cord-292688-w4zvfkyl	81	19	of	of	IN
cord-292688-w4zvfkyl	81	20	the	the	DT
cord-292688-w4zvfkyl	81	21	regulated	regulate	VBN
cord-292688-w4zvfkyl	81	22	secretory	secretory	JJ
cord-292688-w4zvfkyl	81	23	proteins	protein	NNS
cord-292688-w4zvfkyl	81	24	with	with	IN
cord-292688-w4zvfkyl	81	25	the	the	DT
cord-292688-w4zvfkyl	81	26	membrane	membrane	NN
cord-292688-w4zvfkyl	81	27	.	.	.
cord-292688-w4zvfkyl	82	1	on	on	IN
cord-292688-w4zvfkyl	82	2	the	the	DT
cord-292688-w4zvfkyl	82	3	¢nal	¢nal	JJ
cord-292688-w4zvfkyl	82	4	size	size	NN
cord-292688-w4zvfkyl	82	5	.	.	.
cord-292688-w4zvfkyl	83	1	In	in	IN
cord-292688-w4zvfkyl	83	2	support	support	NN
cord-292688-w4zvfkyl	83	3	of	of	IN
cord-292688-w4zvfkyl	83	4	this	this	DT
cord-292688-w4zvfkyl	83	5	idea	idea	NN
cord-292688-w4zvfkyl	83	6	,	,	,
cord-292688-w4zvfkyl	83	7	a	a	DT
cord-292688-w4zvfkyl	83	8	size	size	NN
cord-292688-w4zvfkyl	83	9	difference	difference	NN
cord-292688-w4zvfkyl	83	10	has	have	VBZ
cord-292688-w4zvfkyl	83	11	also	also	RB
cord-292688-w4zvfkyl	83	12	been	be	VBN
cord-292688-w4zvfkyl	83	13	seen	see	VBN
cord-292688-w4zvfkyl	83	14	in	in	IN
cord-292688-w4zvfkyl	83	15	the	the	DT
cord-292688-w4zvfkyl	83	16	secretory	secretory	JJ
cord-292688-w4zvfkyl	83	17	granules	granule	NNS
cord-292688-w4zvfkyl	83	18	in	in	IN
cord-292688-w4zvfkyl	83	19	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	83	20	cells	cell	NNS
cord-292688-w4zvfkyl	83	21	of	of	IN
cord-292688-w4zvfkyl	83	22	the	the	DT
cord-292688-w4zvfkyl	83	23	pituitary	pituitary	NN
cord-292688-w4zvfkyl	83	24	(	(	-LRB-
cord-292688-w4zvfkyl	83	25	for	for	IN
cord-292688-w4zvfkyl	83	26	review	review	NN
cord-292688-w4zvfkyl	83	27	see	see	VB
cord-292688-w4zvfkyl	83	28	[	[	-LRB-
cord-292688-w4zvfkyl	83	29	29	29	CD
cord-292688-w4zvfkyl	83	30	]	]	-RRB-
cord-292688-w4zvfkyl	83	31	)	)	-RRB-
cord-292688-w4zvfkyl	83	32	.	.	.
cord-292688-w4zvfkyl	84	1	While	while	IN
cord-292688-w4zvfkyl	84	2	the	the	DT
cord-292688-w4zvfkyl	84	3	data	datum	NNS
cord-292688-w4zvfkyl	84	4	to	to	IN
cord-292688-w4zvfkyl	84	5	support`sorting	support`sorting	NNP
cord-292688-w4zvfkyl	84	6	by	by	IN
cord-292688-w4zvfkyl	84	7	retention	retention	NN
cord-292688-w4zvfkyl	84	8	'	'	''
cord-292688-w4zvfkyl	84	9	[	[	-LRB-
cord-292688-w4zvfkyl	84	10	30	30	CD
cord-292688-w4zvfkyl	84	11	]	]	-RRB-
cord-292688-w4zvfkyl	84	12	is	be	VBZ
cord-292688-w4zvfkyl	84	13	compelling	compelling	JJ
cord-292688-w4zvfkyl	84	14	,	,	,
cord-292688-w4zvfkyl	84	15	the	the	DT
cord-292688-w4zvfkyl	84	16	data	datum	NNS
cord-292688-w4zvfkyl	84	17	to	to	TO
cord-292688-w4zvfkyl	84	18	support	support	VB
cord-292688-w4zvfkyl	84	19	the`sorting	the`sorting	NNP
cord-292688-w4zvfkyl	84	20	for	for	IN
cord-292688-w4zvfkyl	84	21	entry	entry	NN
cord-292688-w4zvfkyl	84	22	'	'	''
cord-292688-w4zvfkyl	84	23	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	84	24	,	,	,
cord-292688-w4zvfkyl	84	25	where	where	WRB
cord-292688-w4zvfkyl	84	26	the	the	DT
cord-292688-w4zvfkyl	84	27	bulk	bulk	NN
cord-292688-w4zvfkyl	84	28	of	of	IN
cord-292688-w4zvfkyl	84	29	sorting	sorting	NN
cord-292688-w4zvfkyl	84	30	has	have	VBZ
cord-292688-w4zvfkyl	84	31	been	be	VBN
cord-292688-w4zvfkyl	84	32	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	84	33	to	to	TO
cord-292688-w4zvfkyl	84	34	occur	occur	VB
cord-292688-w4zvfkyl	84	35	in	in	IN
cord-292688-w4zvfkyl	84	36	the	the	DT
cord-292688-w4zvfkyl	84	37	TGN	TGN	NNP
cord-292688-w4zvfkyl	84	38	prior	prior	RB
cord-292688-w4zvfkyl	84	39	to	to	IN
cord-292688-w4zvfkyl	84	40	ISG	ISG	NNP
cord-292688-w4zvfkyl	84	41	formation	formation	NN
cord-292688-w4zvfkyl	84	42	,	,	,
cord-292688-w4zvfkyl	84	43	is	be	VBZ
cord-292688-w4zvfkyl	84	44	equally	equally	RB
cord-292688-w4zvfkyl	84	45	compelling	compelling	JJ
cord-292688-w4zvfkyl	84	46	(	(	-LRB-
cord-292688-w4zvfkyl	84	47	see	see	VB
cord-292688-w4zvfkyl	84	48	above	above	RB
cord-292688-w4zvfkyl	84	49	)	)	-RRB-
cord-292688-w4zvfkyl	84	50	.	.	.
cord-292688-w4zvfkyl	85	1	To	to	TO
cord-292688-w4zvfkyl	85	2	reconcile	reconcile	VB
cord-292688-w4zvfkyl	85	3	these	these	DT
cord-292688-w4zvfkyl	85	4	two	two	CD
cord-292688-w4zvfkyl	85	5	hypotheses	hypothesis	NNS
cord-292688-w4zvfkyl	85	6	,	,	,
cord-292688-w4zvfkyl	85	7	it	-PRON-	PRP
cord-292688-w4zvfkyl	85	8	has	have	VBZ
cord-292688-w4zvfkyl	85	9	been	be	VBN
cord-292688-w4zvfkyl	85	10	suggested	suggest	VBN
cord-292688-w4zvfkyl	85	11	[	[	-LRB-
cord-292688-w4zvfkyl	85	12	22	22	CD
cord-292688-w4zvfkyl	85	13	,	,	,
cord-292688-w4zvfkyl	85	14	31	31	CD
cord-292688-w4zvfkyl	85	15	]	]	-RRB-
cord-292688-w4zvfkyl	85	16	that	that	IN
cord-292688-w4zvfkyl	85	17	whether	whether	IN
cord-292688-w4zvfkyl	85	18	sorting	sorting	NN
cord-292688-w4zvfkyl	85	19	is	be	VBZ
cord-292688-w4zvfkyl	85	20	predominantly	predominantly	RB
cord-292688-w4zvfkyl	85	21	TGNbased	tgnbased	JJ
cord-292688-w4zvfkyl	85	22	(	(	-LRB-
cord-292688-w4zvfkyl	85	23	sorting	sort	VBG
cord-292688-w4zvfkyl	85	24	for	for	IN
cord-292688-w4zvfkyl	85	25	entry	entry	NN
cord-292688-w4zvfkyl	85	26	)	)	-RRB-
cord-292688-w4zvfkyl	85	27	or	or	CC
cord-292688-w4zvfkyl	85	28	ISG	ISG	NNP
cord-292688-w4zvfkyl	85	29	-	-	HYPH
cord-292688-w4zvfkyl	85	30	based	base	VBN
cord-292688-w4zvfkyl	85	31	(	(	-LRB-
cord-292688-w4zvfkyl	85	32	sorting	sort	VBG
cord-292688-w4zvfkyl	85	33	by	by	IN
cord-292688-w4zvfkyl	85	34	retention	retention	NN
cord-292688-w4zvfkyl	85	35	)	)	-RRB-
cord-292688-w4zvfkyl	85	36	might	may	MD
cord-292688-w4zvfkyl	85	37	depend	depend	VB
cord-292688-w4zvfkyl	85	38	both	both	DT
cord-292688-w4zvfkyl	85	39	on	on	IN
cord-292688-w4zvfkyl	85	40	the	the	DT
cord-292688-w4zvfkyl	85	41	propensity	propensity	NN
cord-292688-w4zvfkyl	85	42	of	of	IN
cord-292688-w4zvfkyl	85	43	the	the	DT
cord-292688-w4zvfkyl	85	44	major	major	JJ
cord-292688-w4zvfkyl	85	45	prohormone	prohormone	NN
cord-292688-w4zvfkyl	85	46	species	specie	NNS
cord-292688-w4zvfkyl	85	47	to	to	TO
cord-292688-w4zvfkyl	85	48	aggregate	aggregate	VB
cord-292688-w4zvfkyl	85	49	,	,	,
cord-292688-w4zvfkyl	85	50	or	or	CC
cord-292688-w4zvfkyl	85	51	not	not	RB
cord-292688-w4zvfkyl	85	52	,	,	,
cord-292688-w4zvfkyl	85	53	and	and	CC
cord-292688-w4zvfkyl	85	54	the	the	DT
cord-292688-w4zvfkyl	85	55	relative	relative	JJ
cord-292688-w4zvfkyl	85	56	rates	rate	NNS
cord-292688-w4zvfkyl	85	57	of	of	IN
cord-292688-w4zvfkyl	85	58	prohormone	prohormone	NN
cord-292688-w4zvfkyl	85	59	synthesis	synthesis	NN
cord-292688-w4zvfkyl	85	60	and	and	CC
cord-292688-w4zvfkyl	85	61	vesicle	vesicle	NN
cord-292688-w4zvfkyl	85	62	formation	formation	NN
cord-292688-w4zvfkyl	85	63	in	in	IN
cord-292688-w4zvfkyl	85	64	the	the	DT
cord-292688-w4zvfkyl	85	65	TGN	TGN	NNP
cord-292688-w4zvfkyl	85	66	.	.	.
cord-292688-w4zvfkyl	86	1	The	the	DT
cord-292688-w4zvfkyl	86	2	paradigm	paradigm	NN
cord-292688-w4zvfkyl	86	3	for	for	IN
cord-292688-w4zvfkyl	86	4	sorting	sort	VBG
cord-292688-w4zvfkyl	86	5	of	of	IN
cord-292688-w4zvfkyl	86	6	soluble	soluble	JJ
cord-292688-w4zvfkyl	86	7	proteins	protein	NNS
cord-292688-w4zvfkyl	86	8	into	into	IN
cord-292688-w4zvfkyl	86	9	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	86	10	is	be	VBZ
cord-292688-w4zvfkyl	86	11	receptor	receptor	NN
cord-292688-w4zvfkyl	86	12	-	-	HYPH
cord-292688-w4zvfkyl	86	13	mediated	mediate	VBN
cord-292688-w4zvfkyl	86	14	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	86	15	at	at	IN
cord-292688-w4zvfkyl	86	16	the	the	DT
cord-292688-w4zvfkyl	86	17	plasma	plasma	NN
cord-292688-w4zvfkyl	86	18	membrane	membrane	NN
cord-292688-w4zvfkyl	86	19	:	:	:
cord-292688-w4zvfkyl	86	20	a	a	DT
cord-292688-w4zvfkyl	86	21	receptor	receptor	NN
cord-292688-w4zvfkyl	86	22	binds	bind	VBZ
cord-292688-w4zvfkyl	86	23	a	a	DT
cord-292688-w4zvfkyl	86	24	ligand	ligand	NN
cord-292688-w4zvfkyl	86	25	and	and	CC
cord-292688-w4zvfkyl	86	26	sequesters	sequester	VBZ
cord-292688-w4zvfkyl	86	27	the	the	DT
cord-292688-w4zvfkyl	86	28	ligand	ligand	NN
cord-292688-w4zvfkyl	86	29	for	for	IN
cord-292688-w4zvfkyl	86	30	transport	transport	NN
cord-292688-w4zvfkyl	86	31	to	to	IN
cord-292688-w4zvfkyl	86	32	a	a	DT
cord-292688-w4zvfkyl	86	33	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	86	34	compartment	compartment	NN
cord-292688-w4zvfkyl	86	35	in	in	IN
cord-292688-w4zvfkyl	86	36	a	a	DT
cord-292688-w4zvfkyl	86	37	coat	coat	NN
cord-292688-w4zvfkyl	86	38	-	-	HYPH
cord-292688-w4zvfkyl	86	39	dependent	dependent	JJ
cord-292688-w4zvfkyl	86	40	fashion	fashion	NN
cord-292688-w4zvfkyl	86	41	.	.	.
cord-292688-w4zvfkyl	87	1	This	this	DT
cord-292688-w4zvfkyl	87	2	model	model	NN
cord-292688-w4zvfkyl	87	3	has	have	VBZ
cord-292688-w4zvfkyl	87	4	been	be	VBN
cord-292688-w4zvfkyl	87	5	extended	extend	VBN
cord-292688-w4zvfkyl	87	6	to	to	IN
cord-292688-w4zvfkyl	87	7	a	a	DT
cord-292688-w4zvfkyl	87	8	variety	variety	NN
cord-292688-w4zvfkyl	87	9	of	of	IN
cord-292688-w4zvfkyl	87	10	intracellular	intracellular	JJ
cord-292688-w4zvfkyl	87	11	transport	transport	NN
cord-292688-w4zvfkyl	87	12	events	event	NNS
cord-292688-w4zvfkyl	87	13	including	include	VBG
cord-292688-w4zvfkyl	87	14	sorting	sort	VBG
cord-292688-w4zvfkyl	87	15	of	of	IN
cord-292688-w4zvfkyl	87	16	regulated	regulated	JJ
cord-292688-w4zvfkyl	87	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	87	18	proteins	protein	NNS
cord-292688-w4zvfkyl	87	19	in	in	IN
cord-292688-w4zvfkyl	87	20	the	the	DT
cord-292688-w4zvfkyl	87	21	TGN	TGN	NNP
cord-292688-w4zvfkyl	87	22	[	[	-LRB-
cord-292688-w4zvfkyl	87	23	32	32	CD
cord-292688-w4zvfkyl	87	24	]	]	-RRB-
cord-292688-w4zvfkyl	87	25	.	.	.
cord-292688-w4zvfkyl	88	1	Regardless	regardless	RB
cord-292688-w4zvfkyl	88	2	of	of	IN
cord-292688-w4zvfkyl	88	3	whether	whether	IN
cord-292688-w4zvfkyl	88	4	a	a	DT
cord-292688-w4zvfkyl	88	5	single	single	JJ
cord-292688-w4zvfkyl	88	6	molecule	molecule	NN
cord-292688-w4zvfkyl	88	7	or	or	CC
cord-292688-w4zvfkyl	88	8	a	a	DT
cord-292688-w4zvfkyl	88	9	molecular	molecular	JJ
cord-292688-w4zvfkyl	88	10	aggregate	aggregate	NN
cord-292688-w4zvfkyl	88	11	is	be	VBZ
cord-292688-w4zvfkyl	88	12	sorted	sort	VBN
cord-292688-w4zvfkyl	88	13	,	,	,
cord-292688-w4zvfkyl	88	14	this	this	DT
cord-292688-w4zvfkyl	88	15	paradigm	paradigm	NN
cord-292688-w4zvfkyl	88	16	has	have	VBZ
cord-292688-w4zvfkyl	88	17	remained	remain	VBN
cord-292688-w4zvfkyl	88	18	attractive	attractive	JJ
cord-292688-w4zvfkyl	88	19	enough	enough	RB
cord-292688-w4zvfkyl	88	20	for	for	IN
cord-292688-w4zvfkyl	88	21	investigators	investigator	NNS
cord-292688-w4zvfkyl	88	22	to	to	TO
cord-292688-w4zvfkyl	88	23	continue	continue	VB
cord-292688-w4zvfkyl	88	24	to	to	TO
cord-292688-w4zvfkyl	88	25	pursue	pursue	VB
cord-292688-w4zvfkyl	88	26	the	the	DT
cord-292688-w4zvfkyl	88	27	putative`sorting	putative`sorting	NNP
cord-292688-w4zvfkyl	88	28	receptor	receptor	NN
cord-292688-w4zvfkyl	88	29	'	'	''
cord-292688-w4zvfkyl	88	30	.	.	.
cord-292688-w4zvfkyl	89	1	The	the	DT
cord-292688-w4zvfkyl	89	2	putative	putative	JJ
cord-292688-w4zvfkyl	89	3	sorting	sorting	NN
cord-292688-w4zvfkyl	89	4	receptor	receptor	NN
cord-292688-w4zvfkyl	89	5	could	could	MD
cord-292688-w4zvfkyl	89	6	then	then	RB
cord-292688-w4zvfkyl	89	7	interact	interact	VB
cord-292688-w4zvfkyl	89	8	directly	directly	RB
cord-292688-w4zvfkyl	89	9	or	or	CC
cord-292688-w4zvfkyl	89	10	indirectly	indirectly	RB
cord-292688-w4zvfkyl	89	11	with	with	IN
cord-292688-w4zvfkyl	89	12	the	the	DT
cord-292688-w4zvfkyl	89	13	cytosolic	cytosolic	JJ
cord-292688-w4zvfkyl	89	14	machinery	machinery	NN
cord-292688-w4zvfkyl	89	15	involved	involve	VBN
cord-292688-w4zvfkyl	89	16	in	in	IN
cord-292688-w4zvfkyl	89	17	the	the	DT
cord-292688-w4zvfkyl	89	18	vesicle	vesicle	NN
cord-292688-w4zvfkyl	89	19	formation	formation	NN
cord-292688-w4zvfkyl	89	20	.	.	.
cord-292688-w4zvfkyl	90	1	The	the	DT
cord-292688-w4zvfkyl	90	2	search	search	NN
cord-292688-w4zvfkyl	90	3	for	for	IN
cord-292688-w4zvfkyl	90	4	a	a	DT
cord-292688-w4zvfkyl	90	5	sorting	sorting	NN
cord-292688-w4zvfkyl	90	6	receptor	receptor	NN
cord-292688-w4zvfkyl	90	7	has	have	VBZ
cord-292688-w4zvfkyl	90	8	been	be	VBN
cord-292688-w4zvfkyl	90	9	approached	approach	VBN
cord-292688-w4zvfkyl	90	10	from	from	IN
cord-292688-w4zvfkyl	90	11	both	both	CC
cord-292688-w4zvfkyl	90	12	the	the	DT
cord-292688-w4zvfkyl	90	13	ligand	ligand	NN
cord-292688-w4zvfkyl	90	14	side	side	NN
cord-292688-w4zvfkyl	90	15	,	,	,
cord-292688-w4zvfkyl	90	16	i.e.	i.e.	FW
cord-292688-w4zvfkyl	90	17	identi¢cation	identi¢cation	NN
cord-292688-w4zvfkyl	90	18	of	of	IN
cord-292688-w4zvfkyl	90	19	sorting	sort	VBG
cord-292688-w4zvfkyl	90	20	signals	signal	NNS
cord-292688-w4zvfkyl	90	21	in	in	IN
cord-292688-w4zvfkyl	90	22	the	the	DT
cord-292688-w4zvfkyl	90	23	ligand	ligand	NN
cord-292688-w4zvfkyl	90	24	,	,	,
cord-292688-w4zvfkyl	90	25	and	and	CC
cord-292688-w4zvfkyl	90	26	the	the	DT
cord-292688-w4zvfkyl	90	27	receptor	receptor	NN
cord-292688-w4zvfkyl	90	28	side	side	NN
cord-292688-w4zvfkyl	90	29	,	,	,
cord-292688-w4zvfkyl	90	30	i.e.	i.e.	FW
cord-292688-w4zvfkyl	90	31	identi-¢cation	identi-¢cation	NN
cord-292688-w4zvfkyl	90	32	of	of	IN
cord-292688-w4zvfkyl	90	33	membrane	membrane	NN
cord-292688-w4zvfkyl	90	34	proteins	protein	NNS
cord-292688-w4zvfkyl	90	35	which	which	WDT
cord-292688-w4zvfkyl	90	36	bind	bind	VBP
cord-292688-w4zvfkyl	90	37	regulated	regulated	JJ
cord-292688-w4zvfkyl	90	38	secretory	secretory	JJ
cord-292688-w4zvfkyl	90	39	proteins	protein	NNS
cord-292688-w4zvfkyl	90	40	.	.	.
cord-292688-w4zvfkyl	91	1	Recent	recent	JJ
cord-292688-w4zvfkyl	91	2	experiments	experiment	NNS
cord-292688-w4zvfkyl	91	3	have	have	VBP
cord-292688-w4zvfkyl	91	4	focused	focus	VBN
cord-292688-w4zvfkyl	91	5	on	on	IN
cord-292688-w4zvfkyl	91	6	an	an	DT
cord-292688-w4zvfkyl	91	7	N	n	CD
cord-292688-w4zvfkyl	91	8	-	-	HYPH
cord-292688-w4zvfkyl	91	9	terminal	terminal	JJ
cord-292688-w4zvfkyl	91	10	disulphide	disulphide	NN
cord-292688-w4zvfkyl	91	11	loop	loop	NN
cord-292688-w4zvfkyl	91	12	structure	structure	NN
cord-292688-w4zvfkyl	91	13	found	find	VBN
cord-292688-w4zvfkyl	91	14	in	in	IN
cord-292688-w4zvfkyl	91	15	POMC	POMC	NNP
cord-292688-w4zvfkyl	91	16	,	,	,
cord-292688-w4zvfkyl	91	17	provasopressin	provasopressin	NN
cord-292688-w4zvfkyl	91	18	,	,	,
cord-292688-w4zvfkyl	91	19	pro	pro	JJ
cord-292688-w4zvfkyl	91	20	-	-	JJ
cord-292688-w4zvfkyl	91	21	oxytocin	oxytocin	JJ
cord-292688-w4zvfkyl	91	22	,	,	,
cord-292688-w4zvfkyl	91	23	prodynorphin	prodynorphin	NNP
cord-292688-w4zvfkyl	91	24	,	,	,
cord-292688-w4zvfkyl	91	25	proenkephalin	proenkephalin	NNP
cord-292688-w4zvfkyl	91	26	,	,	,
cord-292688-w4zvfkyl	91	27	CgA	CgA	NNP
cord-292688-w4zvfkyl	91	28	and	and	CC
cord-292688-w4zvfkyl	91	29	CgB	cgb	JJ
cord-292688-w4zvfkyl	91	30	[	[	-LRB-
cord-292688-w4zvfkyl	91	31	1	1	CD
cord-292688-w4zvfkyl	91	32	,	,	,
cord-292688-w4zvfkyl	91	33	33	33	CD
cord-292688-w4zvfkyl	91	34	]	]	-RRB-
cord-292688-w4zvfkyl	91	35	.	.	.
cord-292688-w4zvfkyl	92	1	The	the	DT
cord-292688-w4zvfkyl	92	2	N	n	CD
cord-292688-w4zvfkyl	92	3	-	-	HYPH
cord-292688-w4zvfkyl	92	4	terminal	terminal	NN
cord-292688-w4zvfkyl	92	5	26	26	CD
cord-292688-w4zvfkyl	92	6	amino	amino	JJ
cord-292688-w4zvfkyl	92	7	acids	acid	NNS
cord-292688-w4zvfkyl	92	8	of	of	IN
cord-292688-w4zvfkyl	92	9	POMC	POMC	NNP
cord-292688-w4zvfkyl	92	10	have	have	VBP
cord-292688-w4zvfkyl	92	11	been	be	VBN
cord-292688-w4zvfkyl	92	12	shown	show	VBN
cord-292688-w4zvfkyl	92	13	to	to	TO
cord-292688-w4zvfkyl	92	14	contain	contain	VB
cord-292688-w4zvfkyl	92	15	a	a	DT
cord-292688-w4zvfkyl	92	16	signal	signal	NN
cord-292688-w4zvfkyl	92	17	which	which	WDT
cord-292688-w4zvfkyl	92	18	sorts	sort	VBZ
cord-292688-w4zvfkyl	92	19	a	a	DT
cord-292688-w4zvfkyl	92	20	reporter	reporter	NN
cord-292688-w4zvfkyl	92	21	molecule	molecule	NN
cord-292688-w4zvfkyl	92	22	into	into	IN
cord-292688-w4zvfkyl	92	23	secretory	secretory	JJ
cord-292688-w4zvfkyl	92	24	granules	granule	NNS
cord-292688-w4zvfkyl	92	25	in	in	IN
cord-292688-w4zvfkyl	92	26	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	92	27	cells	cell	NNS
cord-292688-w4zvfkyl	92	28	[	[	-LRB-
cord-292688-w4zvfkyl	92	29	34	34	CD
cord-292688-w4zvfkyl	92	30	]	]	-RRB-
cord-292688-w4zvfkyl	92	31	.	.	.
cord-292688-w4zvfkyl	93	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	93	2	has	have	VBZ
cord-292688-w4zvfkyl	93	3	been	be	VBN
cord-292688-w4zvfkyl	93	4	further	further	RB
cord-292688-w4zvfkyl	93	5	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	93	6	that	that	IN
cord-292688-w4zvfkyl	93	7	a	a	DT
cord-292688-w4zvfkyl	93	8	disulphide	disulphide	JJ
cord-292688-w4zvfkyl	93	9	bond	bond	NN
cord-292688-w4zvfkyl	93	10	,	,	,
cord-292688-w4zvfkyl	93	11	within	within	IN
cord-292688-w4zvfkyl	93	12	this	this	DT
cord-292688-w4zvfkyl	93	13	sequence	sequence	NN
cord-292688-w4zvfkyl	93	14	of	of	IN
cord-292688-w4zvfkyl	93	15	26	26	CD
cord-292688-w4zvfkyl	93	16	amino	amino	JJ
cord-292688-w4zvfkyl	93	17	acids	acid	NNS
cord-292688-w4zvfkyl	93	18	,	,	,
cord-292688-w4zvfkyl	93	19	forms	form	VBZ
cord-292688-w4zvfkyl	93	20	an	an	DT
cord-292688-w4zvfkyl	93	21	amphipathic	amphipathic	JJ
cord-292688-w4zvfkyl	93	22	loop	loop	NN
cord-292688-w4zvfkyl	93	23	structure	structure	NN
cord-292688-w4zvfkyl	93	24	which	which	WDT
cord-292688-w4zvfkyl	93	25	may	may	MD
cord-292688-w4zvfkyl	93	26	play	play	VB
cord-292688-w4zvfkyl	93	27	a	a	DT
cord-292688-w4zvfkyl	93	28	role	role	NN
cord-292688-w4zvfkyl	93	29	in	in	IN
cord-292688-w4zvfkyl	93	30	sorting	sort	VBG
cord-292688-w4zvfkyl	93	31	POMC	POMC	NNP
cord-292688-w4zvfkyl	93	32	to	to	IN
cord-292688-w4zvfkyl	93	33	ISGs	ISGs	NNPS
cord-292688-w4zvfkyl	93	34	[	[	-LRB-
cord-292688-w4zvfkyl	93	35	33	33	CD
cord-292688-w4zvfkyl	93	36	]	]	-RRB-
cord-292688-w4zvfkyl	93	37	.	.	.
cord-292688-w4zvfkyl	94	1	This	this	DT
cord-292688-w4zvfkyl	94	2	data	data	NN
cord-292688-w4zvfkyl	94	3	is	be	VBZ
cord-292688-w4zvfkyl	94	4	supported	support	VBN
cord-292688-w4zvfkyl	94	5	by	by	IN
cord-292688-w4zvfkyl	94	6	experiments	experiment	NNS
cord-292688-w4zvfkyl	94	7	in	in	IN
cord-292688-w4zvfkyl	94	8	which	which	WDT
cord-292688-w4zvfkyl	94	9	the	the	DT
cord-292688-w4zvfkyl	94	10	analogous	analogous	JJ
cord-292688-w4zvfkyl	94	11	disulphide	disulphide	JJ
cord-292688-w4zvfkyl	94	12	bond	bond	NN
cord-292688-w4zvfkyl	94	13	of	of	IN
cord-292688-w4zvfkyl	94	14	CgB	CgB	NNP
cord-292688-w4zvfkyl	94	15	was	be	VBD
cord-292688-w4zvfkyl	94	16	disrupted	disrupt	VBN
cord-292688-w4zvfkyl	94	17	by	by	IN
cord-292688-w4zvfkyl	94	18	incubation	incubation	NN
cord-292688-w4zvfkyl	94	19	of	of	IN
cord-292688-w4zvfkyl	94	20	PC12	pc12	JJ
cord-292688-w4zvfkyl	94	21	cells	cell	NNS
cord-292688-w4zvfkyl	94	22	with	with	IN
cord-292688-w4zvfkyl	94	23	DTT	DTT	NNP
cord-292688-w4zvfkyl	94	24	,	,	,
cord-292688-w4zvfkyl	94	25	leading	lead	VBG
cord-292688-w4zvfkyl	94	26	to	to	IN
cord-292688-w4zvfkyl	94	27	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	94	28	secretion	secretion	NN
cord-292688-w4zvfkyl	94	29	of	of	IN
cord-292688-w4zvfkyl	94	30	CgB	cgb	JJ
cord-292688-w4zvfkyl	94	31	[	[	-LRB-
cord-292688-w4zvfkyl	94	32	35	35	CD
cord-292688-w4zvfkyl	94	33	]	]	-RRB-
cord-292688-w4zvfkyl	94	34	.	.	.
cord-292688-w4zvfkyl	95	1	In	in	IN
cord-292688-w4zvfkyl	95	2	pursuit	pursuit	NN
cord-292688-w4zvfkyl	95	3	of	of	IN
cord-292688-w4zvfkyl	95	4	a	a	DT
cord-292688-w4zvfkyl	95	5	receptor	receptor	NN
cord-292688-w4zvfkyl	95	6	which	which	WDT
cord-292688-w4zvfkyl	95	7	would	would	MD
cord-292688-w4zvfkyl	95	8	recognize	recognize	VB
cord-292688-w4zvfkyl	95	9	the	the	DT
cord-292688-w4zvfkyl	95	10	sorting	sorting	NN
cord-292688-w4zvfkyl	95	11	motif	motif	NN
cord-292688-w4zvfkyl	95	12	researchers	researcher	NNS
cord-292688-w4zvfkyl	95	13	have	have	VBP
cord-292688-w4zvfkyl	95	14	used	use	VBN
cord-292688-w4zvfkyl	95	15	assays	assay	NNS
cord-292688-w4zvfkyl	95	16	based	base	VBN
cord-292688-w4zvfkyl	95	17	on	on	IN
cord-292688-w4zvfkyl	95	18	the	the	DT
cord-292688-w4zvfkyl	95	19	binding	binding	NN
cord-292688-w4zvfkyl	95	20	of	of	IN
cord-292688-w4zvfkyl	95	21	solubilized	solubilized	JJ
cord-292688-w4zvfkyl	95	22	secretory	secretory	JJ
cord-292688-w4zvfkyl	95	23	granule	granule	NN
cord-292688-w4zvfkyl	95	24	membrane	membrane	NN
cord-292688-w4zvfkyl	95	25	components	component	NNS
cord-292688-w4zvfkyl	95	26	to	to	IN
cord-292688-w4zvfkyl	95	27	immobilized	immobilize	VBN
cord-292688-w4zvfkyl	95	28	regulated	regulated	JJ
cord-292688-w4zvfkyl	95	29	secretory	secretory	JJ
cord-292688-w4zvfkyl	95	30	proteins	protein	NNS
cord-292688-w4zvfkyl	95	31	.	.	.
cord-292688-w4zvfkyl	96	1	As	as	IN
cord-292688-w4zvfkyl	96	2	some	some	DT
cord-292688-w4zvfkyl	96	3	granule`matrix	granule`matrix	NNP
cord-292688-w4zvfkyl	96	4	'	'	POS
cord-292688-w4zvfkyl	96	5	proteins	protein	NNS
cord-292688-w4zvfkyl	96	6	such	such	JJ
cord-292688-w4zvfkyl	96	7	as	as	IN
cord-292688-w4zvfkyl	96	8	CgB	cgb	JJ
cord-292688-w4zvfkyl	96	9	exist	exist	VBP
cord-292688-w4zvfkyl	96	10	as	as	IN
cord-292688-w4zvfkyl	96	11	membrane	membrane	NN
cord-292688-w4zvfkyl	96	12	-	-	HYPH
cord-292688-w4zvfkyl	96	13	bound	bind	VBN
cord-292688-w4zvfkyl	96	14	isoforms	isoform	NNS
cord-292688-w4zvfkyl	96	15	[	[	-LRB-
cord-292688-w4zvfkyl	96	16	36	36	CD
cord-292688-w4zvfkyl	96	17	]	]	-RRB-
cord-292688-w4zvfkyl	96	18	,	,	,
cord-292688-w4zvfkyl	96	19	it	-PRON-	PRP
cord-292688-w4zvfkyl	96	20	has	have	VBZ
cord-292688-w4zvfkyl	96	21	been	be	VBN
cord-292688-w4zvfkyl	96	22	suggested	suggest	VBN
cord-292688-w4zvfkyl	96	23	that	that	IN
cord-292688-w4zvfkyl	96	24	the	the	DT
cord-292688-w4zvfkyl	96	25	membrane	membrane	NN
cord-292688-w4zvfkyl	96	26	bound	bind	VBN
cord-292688-w4zvfkyl	96	27	forms	form	NNS
cord-292688-w4zvfkyl	96	28	of	of	IN
cord-292688-w4zvfkyl	96	29	such	such	JJ
cord-292688-w4zvfkyl	96	30	proteins	protein	NNS
cord-292688-w4zvfkyl	96	31	would	would	MD
cord-292688-w4zvfkyl	96	32	act	act	VB
cord-292688-w4zvfkyl	96	33	as	as	IN
cord-292688-w4zvfkyl	96	34	nucleating	nucleate	VBG
cord-292688-w4zvfkyl	96	35	receptors	receptor	NNS
cord-292688-w4zvfkyl	96	36	to	to	TO
cord-292688-w4zvfkyl	96	37	recruit	recruit	VB
cord-292688-w4zvfkyl	96	38	soluble	soluble	JJ
cord-292688-w4zvfkyl	96	39	regulated	regulated	JJ
cord-292688-w4zvfkyl	96	40	secretory	secretory	JJ
cord-292688-w4zvfkyl	96	41	proteins	protein	NNS
cord-292688-w4zvfkyl	96	42	[	[	-LRB-
cord-292688-w4zvfkyl	96	43	3	3	CD
cord-292688-w4zvfkyl	96	44	]	]	-RRB-
cord-292688-w4zvfkyl	96	45	.	.	.
cord-292688-w4zvfkyl	97	1	Indeed	indeed	RB
cord-292688-w4zvfkyl	97	2	,	,	,
cord-292688-w4zvfkyl	97	3	recent	recent	JJ
cord-292688-w4zvfkyl	97	4	experiments	experiment	NNS
cord-292688-w4zvfkyl	97	5	have	have	VBP
cord-292688-w4zvfkyl	97	6	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	97	7	that	that	IN
cord-292688-w4zvfkyl	97	8	the	the	DT
cord-292688-w4zvfkyl	97	9	membrane	membrane	NN
cord-292688-w4zvfkyl	97	10	associated	associate	VBN
cord-292688-w4zvfkyl	97	11	form	form	NN
cord-292688-w4zvfkyl	97	12	of	of	IN
cord-292688-w4zvfkyl	97	13	carboxypeptidase	carboxypeptidase	NN
cord-292688-w4zvfkyl	97	14	E	e	NN
cord-292688-w4zvfkyl	97	15	,	,	,
cord-292688-w4zvfkyl	97	16	a	a	DT
cord-292688-w4zvfkyl	97	17	granule	granule	NN
cord-292688-w4zvfkyl	97	18	speci¢c	speci¢c	NNP
cord-292688-w4zvfkyl	97	19	carboxypeptidase	carboxypeptidase	NN
cord-292688-w4zvfkyl	97	20	[	[	-LRB-
cord-292688-w4zvfkyl	97	21	37	37	CD
cord-292688-w4zvfkyl	97	22	]	]	-RRB-
cord-292688-w4zvfkyl	97	23	,	,	,
cord-292688-w4zvfkyl	97	24	can	can	MD
cord-292688-w4zvfkyl	97	25	function	function	VB
cord-292688-w4zvfkyl	97	26	as	as	IN
cord-292688-w4zvfkyl	97	27	a	a	DT
cord-292688-w4zvfkyl	97	28	sorting	sorting	NN
cord-292688-w4zvfkyl	97	29	receptor	receptor	NN
cord-292688-w4zvfkyl	97	30	[	[	-LRB-
cord-292688-w4zvfkyl	97	31	38	38	CD
cord-292688-w4zvfkyl	97	32	]	]	-RRB-
cord-292688-w4zvfkyl	97	33	.	.	.
cord-292688-w4zvfkyl	98	1	These	these	DT
cord-292688-w4zvfkyl	98	2	observations	observation	NNS
cord-292688-w4zvfkyl	98	3	are	be	VBP
cord-292688-w4zvfkyl	98	4	the	the	DT
cord-292688-w4zvfkyl	98	5	subject	subject	NN
cord-292688-w4zvfkyl	98	6	of	of	IN
cord-292688-w4zvfkyl	98	7	some	some	DT
cord-292688-w4zvfkyl	98	8	debate	debate	NN
cord-292688-w4zvfkyl	98	9	[	[	-LRB-
cord-292688-w4zvfkyl	98	10	31	31	CD
cord-292688-w4zvfkyl	98	11	]	]	-RRB-
cord-292688-w4zvfkyl	98	12	;	;	:
cord-292688-w4zvfkyl	98	13	in	in	IN
cord-292688-w4zvfkyl	98	14	particular	particular	JJ
cord-292688-w4zvfkyl	98	15	,	,	,
cord-292688-w4zvfkyl	98	16	in	in	IN
cord-292688-w4zvfkyl	98	17	light	light	NN
cord-292688-w4zvfkyl	98	18	of	of	IN
cord-292688-w4zvfkyl	98	19	a	a	DT
cord-292688-w4zvfkyl	98	20	recent	recent	JJ
cord-292688-w4zvfkyl	98	21	report	report	NN
cord-292688-w4zvfkyl	98	22	by	by	IN
cord-292688-w4zvfkyl	98	23	Halban	Halban	NNP
cord-292688-w4zvfkyl	98	24	[	[	-LRB-
cord-292688-w4zvfkyl	98	25	39	39	CD
cord-292688-w4zvfkyl	98	26	]	]	-RRB-
cord-292688-w4zvfkyl	98	27	where	where	WRB
cord-292688-w4zvfkyl	98	28	the	the	DT
cord-292688-w4zvfkyl	98	29	absence	absence	NN
cord-292688-w4zvfkyl	98	30	of	of	IN
cord-292688-w4zvfkyl	98	31	carboxypeptidase	carboxypeptidase	NN
cord-292688-w4zvfkyl	98	32	E	e	NN
cord-292688-w4zvfkyl	98	33	in	in	IN
cord-292688-w4zvfkyl	98	34	a	a	DT
cord-292688-w4zvfkyl	98	35	mouse	mouse	NN
cord-292688-w4zvfkyl	98	36	mutant	mutant	JJ
cord-292688-w4zvfkyl	98	37	CPE	CPE	NNP
cord-292688-w4zvfkyl	98	38	fatafat	fatafat	NN
cord-292688-w4zvfkyl	98	39	[	[	-LRB-
cord-292688-w4zvfkyl	98	40	40	40	CD
cord-292688-w4zvfkyl	98	41	]	]	-RRB-
cord-292688-w4zvfkyl	98	42	does	do	VBZ
cord-292688-w4zvfkyl	98	43	not	not	RB
cord-292688-w4zvfkyl	98	44	result	result	VB
cord-292688-w4zvfkyl	98	45	in	in	IN
cord-292688-w4zvfkyl	98	46	abnormal	abnormal	JJ
cord-292688-w4zvfkyl	98	47	insulin	insulin	NN
cord-292688-w4zvfkyl	98	48	processing	processing	NN
cord-292688-w4zvfkyl	98	49	.	.	.
cord-292688-w4zvfkyl	99	1	However	however	RB
cord-292688-w4zvfkyl	99	2	,	,	,
cord-292688-w4zvfkyl	99	3	the	the	DT
cord-292688-w4zvfkyl	99	4	principle	principle	NN
cord-292688-w4zvfkyl	99	5	behind	behind	IN
cord-292688-w4zvfkyl	99	6	the	the	DT
cord-292688-w4zvfkyl	99	7	observations	observation	NNS
cord-292688-w4zvfkyl	99	8	follows	follow	VBZ
cord-292688-w4zvfkyl	99	9	a	a	DT
cord-292688-w4zvfkyl	99	10	common	common	JJ
cord-292688-w4zvfkyl	99	11	theme	theme	NN
cord-292688-w4zvfkyl	99	12	:	:	:
cord-292688-w4zvfkyl	99	13	soluble	soluble	JJ
cord-292688-w4zvfkyl	99	14	regulated	regulated	JJ
cord-292688-w4zvfkyl	99	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	99	16	proteins	protein	NNS
cord-292688-w4zvfkyl	99	17	appear	appear	VBP
cord-292688-w4zvfkyl	99	18	to	to	TO
cord-292688-w4zvfkyl	99	19	interact	interact	VB
cord-292688-w4zvfkyl	99	20	in	in	IN
cord-292688-w4zvfkyl	99	21	a	a	DT
cord-292688-w4zvfkyl	99	22	homo	homo	NN
cord-292688-w4zvfkyl	99	23	-	-	HYPH
cord-292688-w4zvfkyl	99	24	or	or	CC
cord-292688-w4zvfkyl	99	25	heterophillic	heterophillic	JJ
cord-292688-w4zvfkyl	99	26	manner	manner	NN
cord-292688-w4zvfkyl	99	27	with	with	IN
cord-292688-w4zvfkyl	99	28	membrane	membrane	NN
cord-292688-w4zvfkyl	99	29	associated	associate	VBD
cord-292688-w4zvfkyl	99	30	forms	form	NNS
cord-292688-w4zvfkyl	99	31	of	of	IN
cord-292688-w4zvfkyl	99	32	regulated	regulate	VBN
cord-292688-w4zvfkyl	99	33	secretory	secretory	JJ
cord-292688-w4zvfkyl	99	34	proteins	protein	NNS
cord-292688-w4zvfkyl	99	35	.	.	.
cord-292688-w4zvfkyl	100	1	At	at	IN
cord-292688-w4zvfkyl	100	2	this	this	DT
cord-292688-w4zvfkyl	100	3	stage	stage	NN
cord-292688-w4zvfkyl	100	4	,	,	,
cord-292688-w4zvfkyl	100	5	however	however	RB
cord-292688-w4zvfkyl	100	6	,	,	,
cord-292688-w4zvfkyl	100	7	it	-PRON-	PRP
cord-292688-w4zvfkyl	100	8	could	could	MD
cord-292688-w4zvfkyl	100	9	also	also	RB
cord-292688-w4zvfkyl	100	10	be	be	VB
cord-292688-w4zvfkyl	100	11	that	that	IN
cord-292688-w4zvfkyl	100	12	other	other	JJ
cord-292688-w4zvfkyl	100	13	unrelated	unrelated	JJ
cord-292688-w4zvfkyl	100	14	bone	bone	NN
cord-292688-w4zvfkyl	100	15	¢de	¢de	POS
cord-292688-w4zvfkyl	100	16	membrane	membrane	NN
cord-292688-w4zvfkyl	100	17	proteins	protein	NNS
cord-292688-w4zvfkyl	100	18	act	act	VBP
cord-292688-w4zvfkyl	100	19	as	as	IN
cord-292688-w4zvfkyl	100	20	receptors	receptor	NNS
cord-292688-w4zvfkyl	100	21	for	for	IN
cord-292688-w4zvfkyl	100	22	the	the	DT
cord-292688-w4zvfkyl	100	23	aggregate	aggregate	NN
cord-292688-w4zvfkyl	100	24	,	,	,
cord-292688-w4zvfkyl	100	25	such	such	JJ
cord-292688-w4zvfkyl	100	26	as	as	IN
cord-292688-w4zvfkyl	100	27	the	the	DT
cord-292688-w4zvfkyl	100	28	IP3	IP3	NNP
cord-292688-w4zvfkyl	100	29	receptor	receptor	NN
cord-292688-w4zvfkyl	100	30	[	[	-LRB-
cord-292688-w4zvfkyl	100	31	41	41	CD
cord-292688-w4zvfkyl	100	32	,	,	,
cord-292688-w4zvfkyl	100	33	42	42	CD
cord-292688-w4zvfkyl	100	34	]	]	-RRB-
cord-292688-w4zvfkyl	101	1	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	102	1	using	use	VBG
cord-292688-w4zvfkyl	102	2	the	the	DT
cord-292688-w4zvfkyl	102	3	same	same	JJ
cord-292688-w4zvfkyl	102	4	approach	approach	NN
cord-292688-w4zvfkyl	102	5	with	with	IN
cord-292688-w4zvfkyl	102	6	immobilized	immobilize	VBN
cord-292688-w4zvfkyl	102	7	,	,	,
cord-292688-w4zvfkyl	102	8	soluble	soluble	JJ
cord-292688-w4zvfkyl	102	9	CgA.	CgA.	NNP
cord-292688-w4zvfkyl	102	10	A	a	DT
cord-292688-w4zvfkyl	102	11	variety	variety	NN
cord-292688-w4zvfkyl	102	12	of	of	IN
cord-292688-w4zvfkyl	102	13	exogenous	exogenous	JJ
cord-292688-w4zvfkyl	102	14	soluble	soluble	JJ
cord-292688-w4zvfkyl	102	15	proteins	protein	NNS
cord-292688-w4zvfkyl	102	16	,	,	,
cord-292688-w4zvfkyl	102	17	such	such	JJ
cord-292688-w4zvfkyl	102	18	as	as	IN
cord-292688-w4zvfkyl	102	19	renin	renin	NN
cord-292688-w4zvfkyl	102	20	,	,	,
cord-292688-w4zvfkyl	102	21	normally	normally	RB
cord-292688-w4zvfkyl	102	22	expressed	express	VBN
cord-292688-w4zvfkyl	102	23	in	in	IN
cord-292688-w4zvfkyl	102	24	the	the	DT
cord-292688-w4zvfkyl	102	25	kidney	kidney	NN
cord-292688-w4zvfkyl	102	26	[	[	-LRB-
cord-292688-w4zvfkyl	102	27	43	43	CD
cord-292688-w4zvfkyl	102	28	]	]	-RRB-
cord-292688-w4zvfkyl	102	29	to	to	IN
cord-292688-w4zvfkyl	102	30	trypsinogen	trypsinogen	NNP
cord-292688-w4zvfkyl	102	31	,	,	,
cord-292688-w4zvfkyl	102	32	normally	normally	RB
cord-292688-w4zvfkyl	102	33	expressed	express	VBN
cord-292688-w4zvfkyl	102	34	in	in	IN
cord-292688-w4zvfkyl	102	35	pancreatic	pancreatic	JJ
cord-292688-w4zvfkyl	102	36	exocrine	exocrine	JJ
cord-292688-w4zvfkyl	102	37	cells	cell	NNS
cord-292688-w4zvfkyl	102	38	[	[	-LRB-
cord-292688-w4zvfkyl	102	39	44	44	CD
cord-292688-w4zvfkyl	102	40	]	]	-RRB-
cord-292688-w4zvfkyl	102	41	,	,	,
cord-292688-w4zvfkyl	102	42	have	have	VBP
cord-292688-w4zvfkyl	102	43	been	be	VBN
cord-292688-w4zvfkyl	102	44	expressed	express	VBN
cord-292688-w4zvfkyl	102	45	by	by	IN
cord-292688-w4zvfkyl	102	46	transfection	transfection	NN
cord-292688-w4zvfkyl	102	47	in	in	IN
cord-292688-w4zvfkyl	102	48	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	102	49	and	and	CC
cord-292688-w4zvfkyl	102	50	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	102	51	cell	cell	NN
cord-292688-w4zvfkyl	102	52	lines	line	NNS
cord-292688-w4zvfkyl	102	53	.	.	.
cord-292688-w4zvfkyl	103	1	These	these	DT
cord-292688-w4zvfkyl	103	2	exogenous	exogenous	JJ
cord-292688-w4zvfkyl	103	3	molecules	molecule	NNS
cord-292688-w4zvfkyl	103	4	have	have	VBP
cord-292688-w4zvfkyl	103	5	been	be	VBN
cord-292688-w4zvfkyl	103	6	found	find	VBN
cord-292688-w4zvfkyl	103	7	to	to	TO
cord-292688-w4zvfkyl	103	8	be	be	VB
cord-292688-w4zvfkyl	103	9	secreted	secrete	VBN
cord-292688-w4zvfkyl	103	10	in	in	IN
cord-292688-w4zvfkyl	103	11	a	a	DT
cord-292688-w4zvfkyl	103	12	regulated	regulated	JJ
cord-292688-w4zvfkyl	103	13	fashion	fashion	NN
cord-292688-w4zvfkyl	103	14	from	from	IN
cord-292688-w4zvfkyl	103	15	the	the	DT
cord-292688-w4zvfkyl	103	16	transfected	transfecte	VBN
cord-292688-w4zvfkyl	103	17	cells	cell	NNS
cord-292688-w4zvfkyl	103	18	lines	line	NNS
cord-292688-w4zvfkyl	103	19	,	,	,
cord-292688-w4zvfkyl	103	20	suggesting	suggest	VBG
cord-292688-w4zvfkyl	103	21	that	that	IN
cord-292688-w4zvfkyl	103	22	these	these	DT
cord-292688-w4zvfkyl	103	23	proteins	protein	NNS
cord-292688-w4zvfkyl	103	24	have	have	VBP
cord-292688-w4zvfkyl	103	25	been	be	VBN
cord-292688-w4zvfkyl	103	26	stored	store	VBN
cord-292688-w4zvfkyl	103	27	in	in	IN
cord-292688-w4zvfkyl	103	28	secretory	secretory	JJ
cord-292688-w4zvfkyl	103	29	granules	granule	NNS
cord-292688-w4zvfkyl	103	30	.	.	.
cord-292688-w4zvfkyl	104	1	From	from	IN
cord-292688-w4zvfkyl	104	2	these	these	DT
cord-292688-w4zvfkyl	104	3	data	datum	NNS
cord-292688-w4zvfkyl	104	4	it	-PRON-	PRP
cord-292688-w4zvfkyl	104	5	was	be	VBD
cord-292688-w4zvfkyl	104	6	hypothesized	hypothesize	VBN
cord-292688-w4zvfkyl	104	7	that	that	IN
cord-292688-w4zvfkyl	104	8	a	a	DT
cord-292688-w4zvfkyl	104	9	putative	putative	JJ
cord-292688-w4zvfkyl	104	10	sorting	sorting	NN
cord-292688-w4zvfkyl	104	11	signal	signal	NN
cord-292688-w4zvfkyl	104	12	,	,	,
cord-292688-w4zvfkyl	104	13	a	a	DT
cord-292688-w4zvfkyl	104	14	common	common	JJ
cord-292688-w4zvfkyl	104	15	sequence	sequence	NN
cord-292688-w4zvfkyl	104	16	or	or	CC
cord-292688-w4zvfkyl	104	17	structural	structural	JJ
cord-292688-w4zvfkyl	104	18	feature	feature	NN
cord-292688-w4zvfkyl	104	19	,	,	,
cord-292688-w4zvfkyl	104	20	appears	appear	VBZ
cord-292688-w4zvfkyl	104	21	to	to	TO
cord-292688-w4zvfkyl	104	22	be	be	VB
cord-292688-w4zvfkyl	104	23	conserved	conserve	VBN
cord-292688-w4zvfkyl	104	24	across	across	IN
cord-292688-w4zvfkyl	104	25	a	a	DT
cord-292688-w4zvfkyl	104	26	variety	variety	NN
cord-292688-w4zvfkyl	104	27	of	of	IN
cord-292688-w4zvfkyl	104	28	systems	system	NNS
cord-292688-w4zvfkyl	104	29	.	.	.
cord-292688-w4zvfkyl	105	1	This	this	DT
cord-292688-w4zvfkyl	105	2	signal	signal	NN
cord-292688-w4zvfkyl	105	3	is	be	VBZ
cord-292688-w4zvfkyl	105	4	not	not	RB
cord-292688-w4zvfkyl	105	5	,	,	,
cord-292688-w4zvfkyl	105	6	however	however	RB
cord-292688-w4zvfkyl	105	7	,	,	,
cord-292688-w4zvfkyl	105	8	dominant	dominant	JJ
cord-292688-w4zvfkyl	105	9	as	as	IN
cord-292688-w4zvfkyl	105	10	fusion	fusion	NN
cord-292688-w4zvfkyl	105	11	of	of	IN
cord-292688-w4zvfkyl	105	12	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	105	13	with	with	IN
cord-292688-w4zvfkyl	105	14	the	the	DT
cord-292688-w4zvfkyl	105	15	trans	trans	NN
cord-292688-w4zvfkyl	105	16	-	-	NN
cord-292688-w4zvfkyl	105	17	membrane	membrane	NN
cord-292688-w4zvfkyl	105	18	and	and	CC
cord-292688-w4zvfkyl	105	19	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	105	20	domain	domain	NN
cord-292688-w4zvfkyl	105	21	of	of	IN
cord-292688-w4zvfkyl	105	22	CD5	CD5	NNP
cord-292688-w4zvfkyl	105	23	resulted	result	VBD
cord-292688-w4zvfkyl	105	24	in	in	IN
cord-292688-w4zvfkyl	105	25	targeting	targeting	NN
cord-292688-w4zvfkyl	105	26	of	of	IN
cord-292688-w4zvfkyl	105	27	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	105	28	to	to	IN
cord-292688-w4zvfkyl	105	29	the	the	DT
cord-292688-w4zvfkyl	105	30	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	105	31	pathway	pathway	NN
cord-292688-w4zvfkyl	105	32	and	and	CC
cord-292688-w4zvfkyl	105	33	appearance	appearance	NN
cord-292688-w4zvfkyl	105	34	on	on	IN
cord-292688-w4zvfkyl	105	35	the	the	DT
cord-292688-w4zvfkyl	105	36	cell	cell	NN
cord-292688-w4zvfkyl	105	37	surface	surface	NN
cord-292688-w4zvfkyl	105	38	[	[	-LRB-
cord-292688-w4zvfkyl	105	39	45	45	CD
cord-292688-w4zvfkyl	105	40	]	]	-RRB-
cord-292688-w4zvfkyl	105	41	.	.	.
cord-292688-w4zvfkyl	106	1	These	these	DT
cord-292688-w4zvfkyl	106	2	experiments	experiment	NNS
cord-292688-w4zvfkyl	106	3	demonstrate	demonstrate	VBP
cord-292688-w4zvfkyl	106	4	that	that	IN
cord-292688-w4zvfkyl	106	5	a	a	DT
cord-292688-w4zvfkyl	106	6	diverse	diverse	JJ
cord-292688-w4zvfkyl	106	7	set	set	NN
cord-292688-w4zvfkyl	106	8	of	of	IN
cord-292688-w4zvfkyl	106	9	soluble	soluble	JJ
cord-292688-w4zvfkyl	106	10	molecules	molecule	NNS
cord-292688-w4zvfkyl	106	11	can	can	MD
cord-292688-w4zvfkyl	106	12	be	be	VB
cord-292688-w4zvfkyl	106	13	targeted	target	VBN
cord-292688-w4zvfkyl	106	14	to	to	IN
cord-292688-w4zvfkyl	106	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	106	16	granules	granule	NNS
cord-292688-w4zvfkyl	106	17	and	and	CC
cord-292688-w4zvfkyl	106	18	cast	cast	VBD
cord-292688-w4zvfkyl	106	19	doubts	doubt	NNS
cord-292688-w4zvfkyl	106	20	on	on	IN
cord-292688-w4zvfkyl	106	21	the	the	DT
cord-292688-w4zvfkyl	106	22	existence	existence	NN
cord-292688-w4zvfkyl	106	23	of	of	IN
cord-292688-w4zvfkyl	106	24	a	a	DT
cord-292688-w4zvfkyl	106	25	singlè	singlè	JJ
cord-292688-w4zvfkyl	106	26	sorting	sorting	NN
cord-292688-w4zvfkyl	106	27	receptor	receptor	NN
cord-292688-w4zvfkyl	106	28	'	'	''
cord-292688-w4zvfkyl	106	29	because	because	IN
cord-292688-w4zvfkyl	106	30	it	-PRON-	PRP
cord-292688-w4zvfkyl	106	31	is	be	VBZ
cord-292688-w4zvfkyl	106	32	di¤cult	di¤cult	NN
cord-292688-w4zvfkyl	106	33	to	to	TO
cord-292688-w4zvfkyl	106	34	reconcile	reconcile	VB
cord-292688-w4zvfkyl	106	35	the	the	DT
cord-292688-w4zvfkyl	106	36	accurate	accurate	JJ
cord-292688-w4zvfkyl	106	37	sorting	sorting	NN
cord-292688-w4zvfkyl	106	38	of	of	IN
cord-292688-w4zvfkyl	106	39	such	such	PDT
cord-292688-w4zvfkyl	106	40	a	a	DT
cord-292688-w4zvfkyl	106	41	variety	variety	NN
cord-292688-w4zvfkyl	106	42	of	of	IN
cord-292688-w4zvfkyl	106	43	molecules	molecule	NNS
cord-292688-w4zvfkyl	106	44	with	with	IN
cord-292688-w4zvfkyl	106	45	a	a	DT
cord-292688-w4zvfkyl	106	46	single	single	JJ
cord-292688-w4zvfkyl	106	47	receptor	receptor	NN
cord-292688-w4zvfkyl	106	48	.	.	.
cord-292688-w4zvfkyl	107	1	Gerdes	gerde	NNS
cord-292688-w4zvfkyl	107	2	and	and	CC
cord-292688-w4zvfkyl	107	3	colleagues	colleague	NNS
cord-292688-w4zvfkyl	107	4	[	[	-LRB-
cord-292688-w4zvfkyl	107	5	110	110	CD
cord-292688-w4zvfkyl	107	6	]	]	-RRB-
cord-292688-w4zvfkyl	107	7	have	have	VBP
cord-292688-w4zvfkyl	107	8	argued	argue	VBN
cord-292688-w4zvfkyl	107	9	that	that	IN
cord-292688-w4zvfkyl	107	10	e¤cient	e¤cient	NNP
cord-292688-w4zvfkyl	107	11	sorting	sorting	NN
cord-292688-w4zvfkyl	107	12	of	of	IN
cord-292688-w4zvfkyl	107	13	these	these	DT
cord-292688-w4zvfkyl	107	14	molecules	molecule	NNS
cord-292688-w4zvfkyl	107	15	was	be	VBD
cord-292688-w4zvfkyl	107	16	obtained	obtain	VBN
cord-292688-w4zvfkyl	107	17	because	because	IN
cord-292688-w4zvfkyl	107	18	the	the	DT
cord-292688-w4zvfkyl	107	19	exogenous	exogenous	JJ
cord-292688-w4zvfkyl	107	20	molecules	molecule	NNS
cord-292688-w4zvfkyl	107	21	were	be	VBD
cord-292688-w4zvfkyl	107	22	sorted	sort	VBN
cord-292688-w4zvfkyl	107	23	by	by	IN
cord-292688-w4zvfkyl	107	24	co	co	NN
cord-292688-w4zvfkyl	107	25	-	-	NN
cord-292688-w4zvfkyl	107	26	aggregation	aggregation	NN
cord-292688-w4zvfkyl	107	27	with	with	IN
cord-292688-w4zvfkyl	107	28	the	the	DT
cord-292688-w4zvfkyl	107	29	endogenous	endogenous	JJ
cord-292688-w4zvfkyl	107	30	regulated	regulate	VBN
cord-292688-w4zvfkyl	107	31	secretory	secretory	JJ
cord-292688-w4zvfkyl	107	32	proteins	protein	NNS
cord-292688-w4zvfkyl	107	33	.	.	.
cord-292688-w4zvfkyl	108	1	Therefore	therefore	RB
cord-292688-w4zvfkyl	108	2	identi¢cation	identi¢cation	CD
cord-292688-w4zvfkyl	108	3	of	of	IN
cord-292688-w4zvfkyl	108	4	a	a	DT
cord-292688-w4zvfkyl	108	5	sorting	sorting	NN
cord-292688-w4zvfkyl	108	6	sequence	sequence	NN
cord-292688-w4zvfkyl	108	7	could	could	MD
cord-292688-w4zvfkyl	108	8	only	only	RB
cord-292688-w4zvfkyl	108	9	be	be	VB
cord-292688-w4zvfkyl	108	10	achieved	achieve	VBN
cord-292688-w4zvfkyl	108	11	in	in	IN
cord-292688-w4zvfkyl	108	12	essentially	essentially	RB
cord-292688-w4zvfkyl	108	13	a	a	DT
cord-292688-w4zvfkyl	108	14	null	null	JJ
cord-292688-w4zvfkyl	108	15	background	background	NN
cord-292688-w4zvfkyl	108	16	of	of	IN
cord-292688-w4zvfkyl	108	17	endogenous	endogenous	JJ
cord-292688-w4zvfkyl	108	18	regulated	regulate	VBN
cord-292688-w4zvfkyl	108	19	secretory	secretory	JJ
cord-292688-w4zvfkyl	108	20	proteins	protein	NNS
cord-292688-w4zvfkyl	108	21	.	.	.
cord-292688-w4zvfkyl	109	1	They	-PRON-	PRP
cord-292688-w4zvfkyl	109	2	have	have	VBP
cord-292688-w4zvfkyl	109	3	achieved	achieve	VBN
cord-292688-w4zvfkyl	109	4	this	this	DT
cord-292688-w4zvfkyl	109	5	experimentally	experimentally	RB
cord-292688-w4zvfkyl	109	6	using	use	VBG
cord-292688-w4zvfkyl	109	7	a	a	DT
cord-292688-w4zvfkyl	109	8	vaccinia	vaccinia	NN
cord-292688-w4zvfkyl	109	9	virus	virus	NN
cord-292688-w4zvfkyl	109	10	expression	expression	NN
cord-292688-w4zvfkyl	109	11	system	system	NN
cord-292688-w4zvfkyl	109	12	which	which	WDT
cord-292688-w4zvfkyl	109	13	shuts	shut	VBZ
cord-292688-w4zvfkyl	109	14	o	o	NN
cord-292688-w4zvfkyl	109	15	¡	¡	UH
cord-292688-w4zvfkyl	109	16	host	host	NN
cord-292688-w4zvfkyl	109	17	protein	protein	NN
cord-292688-w4zvfkyl	109	18	synthesis	synthesis	NN
cord-292688-w4zvfkyl	109	19	,	,	,
cord-292688-w4zvfkyl	109	20	and	and	CC
cord-292688-w4zvfkyl	109	21	have	have	VBP
cord-292688-w4zvfkyl	109	22	shown	show	VBN
cord-292688-w4zvfkyl	109	23	that	that	IN
cord-292688-w4zvfkyl	109	24	exogenous	exogenous	JJ
cord-292688-w4zvfkyl	109	25	CgB	cgb	NN
cord-292688-w4zvfkyl	109	26	when	when	WRB
cord-292688-w4zvfkyl	109	27	expressed	express	VBN
cord-292688-w4zvfkyl	109	28	in	in	IN
cord-292688-w4zvfkyl	109	29	vaccinia	vaccinia	NN
cord-292688-w4zvfkyl	109	30	virus	virus	NN
cord-292688-w4zvfkyl	109	31	infected	infect	VBN
cord-292688-w4zvfkyl	109	32	PC12	pc12	JJ
cord-292688-w4zvfkyl	109	33	cells	cell	NNS
cord-292688-w4zvfkyl	109	34	can	can	MD
cord-292688-w4zvfkyl	109	35	be	be	VB
cord-292688-w4zvfkyl	109	36	e¤ciently	e¤ciently	RB
cord-292688-w4zvfkyl	109	37	sorted	sort	VBN
cord-292688-w4zvfkyl	109	38	to	to	IN
cord-292688-w4zvfkyl	109	39	secretory	secretory	JJ
cord-292688-w4zvfkyl	109	40	granules	granule	NNS
cord-292688-w4zvfkyl	109	41	but	but	CC
cord-292688-w4zvfkyl	109	42	that	that	IN
cord-292688-w4zvfkyl	109	43	CgB	cgb	RB
cord-292688-w4zvfkyl	109	44	without	without	IN
cord-292688-w4zvfkyl	109	45	the	the	DT
cord-292688-w4zvfkyl	109	46	N	n	CD
cord-292688-w4zvfkyl	109	47	-	-	HYPH
cord-292688-w4zvfkyl	109	48	terminal	terminal	JJ
cord-292688-w4zvfkyl	109	49	disulphide	disulphide	NN
cord-292688-w4zvfkyl	109	50	loop	loop	NN
cord-292688-w4zvfkyl	109	51	(	(	-LRB-
cord-292688-w4zvfkyl	109	52	vcys	vcys	NN
cord-292688-w4zvfkyl	109	53	-	-	HYPH
cord-292688-w4zvfkyl	109	54	CgB	cgb	JJ
cord-292688-w4zvfkyl	109	55	)	)	-RRB-
cord-292688-w4zvfkyl	109	56	was	be	VBD
cord-292688-w4zvfkyl	109	57	not	not	RB
cord-292688-w4zvfkyl	109	58	correctly	correctly	RB
cord-292688-w4zvfkyl	109	59	sorted	sort	VBN
cord-292688-w4zvfkyl	109	60	.	.	.
cord-292688-w4zvfkyl	110	1	Furthermore	furthermore	RB
cord-292688-w4zvfkyl	110	2	,	,	,
cord-292688-w4zvfkyl	110	3	in	in	IN
cord-292688-w4zvfkyl	110	4	the	the	DT
cord-292688-w4zvfkyl	110	5	same	same	JJ
cord-292688-w4zvfkyl	110	6	set	set	NN
cord-292688-w4zvfkyl	110	7	of	of	IN
cord-292688-w4zvfkyl	110	8	experiments	experiment	NNS
cord-292688-w4zvfkyl	110	9	the	the	DT
cord-292688-w4zvfkyl	110	10	authors	author	NNS
cord-292688-w4zvfkyl	110	11	demonstrated	demonstrate	VBD
cord-292688-w4zvfkyl	110	12	that	that	IN
cord-292688-w4zvfkyl	110	13	vcys	vcys	NN
cord-292688-w4zvfkyl	110	14	-	-	HYPH
cord-292688-w4zvfkyl	110	15	CgB	CgB	NNP
cord-292688-w4zvfkyl	110	16	was	be	VBD
cord-292688-w4zvfkyl	110	17	correctly	correctly	RB
cord-292688-w4zvfkyl	110	18	and	and	CC
cord-292688-w4zvfkyl	110	19	e¤ciently	e¤ciently	RB
cord-292688-w4zvfkyl	110	20	sorted	sort	VBD
cord-292688-w4zvfkyl	110	21	after	after	IN
cord-292688-w4zvfkyl	110	22	conventional	conventional	JJ
cord-292688-w4zvfkyl	110	23	transfection	transfection	NN
cord-292688-w4zvfkyl	110	24	protocols	protocol	NNS
cord-292688-w4zvfkyl	110	25	providing	provide	VBG
cord-292688-w4zvfkyl	110	26	additional	additional	JJ
cord-292688-w4zvfkyl	110	27	support	support	NN
cord-292688-w4zvfkyl	110	28	for	for	IN
cord-292688-w4zvfkyl	110	29	their	-PRON-	PRP$
cord-292688-w4zvfkyl	110	30	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	110	31	.	.	.
cord-292688-w4zvfkyl	111	1	Using	use	VBG
cord-292688-w4zvfkyl	111	2	this	this	DT
cord-292688-w4zvfkyl	111	3	powerful	powerful	JJ
cord-292688-w4zvfkyl	111	4	expression	expression	NN
cord-292688-w4zvfkyl	111	5	system	system	NN
cord-292688-w4zvfkyl	111	6	the	the	DT
cord-292688-w4zvfkyl	111	7	authors	author	NNS
cord-292688-w4zvfkyl	111	8	should	should	MD
cord-292688-w4zvfkyl	111	9	be	be	VB
cord-292688-w4zvfkyl	111	10	able	able	JJ
cord-292688-w4zvfkyl	111	11	to	to	TO
cord-292688-w4zvfkyl	111	12	begin	begin	VB
cord-292688-w4zvfkyl	111	13	to	to	TO
cord-292688-w4zvfkyl	111	14	identify	identify	VB
cord-292688-w4zvfkyl	111	15	the	the	DT
cord-292688-w4zvfkyl	111	16	requirements	requirement	NNS
cord-292688-w4zvfkyl	111	17	for	for	IN
cord-292688-w4zvfkyl	111	18	sorting	sorting	NN
cord-292688-w4zvfkyl	111	19	of	of	IN
cord-292688-w4zvfkyl	111	20	soluble	soluble	JJ
cord-292688-w4zvfkyl	111	21	proteins	protein	NNS
cord-292688-w4zvfkyl	111	22	to	to	IN
cord-292688-w4zvfkyl	111	23	the	the	DT
cord-292688-w4zvfkyl	111	24	secretory	secretory	JJ
cord-292688-w4zvfkyl	111	25	granule	granule	NN
cord-292688-w4zvfkyl	111	26	.	.	.
cord-292688-w4zvfkyl	112	1	Lastly	lastly	RB
cord-292688-w4zvfkyl	112	2	,	,	,
cord-292688-w4zvfkyl	112	3	supplementary	supplementary	JJ
cord-292688-w4zvfkyl	112	4	to	to	IN
cord-292688-w4zvfkyl	112	5	the	the	DT
cord-292688-w4zvfkyl	112	6	postulated	postulate	VBN
cord-292688-w4zvfkyl	112	7	role	role	NN
cord-292688-w4zvfkyl	112	8	of	of	IN
cord-292688-w4zvfkyl	112	9	receptors	receptor	NNS
cord-292688-w4zvfkyl	112	10	in	in	IN
cord-292688-w4zvfkyl	112	11	sorting	sort	VBG
cord-292688-w4zvfkyl	112	12	regulated	regulated	JJ
cord-292688-w4zvfkyl	112	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	112	14	proteins	protein	NNS
cord-292688-w4zvfkyl	112	15	or	or	CC
cord-292688-w4zvfkyl	112	16	aggregates	aggregate	NNS
cord-292688-w4zvfkyl	112	17	,	,	,
cord-292688-w4zvfkyl	112	18	sorting	sort	VBG
cord-292688-w4zvfkyl	112	19	receptors	receptor	NNS
cord-292688-w4zvfkyl	112	20	may	may	MD
cord-292688-w4zvfkyl	112	21	also	also	RB
cord-292688-w4zvfkyl	112	22	serve	serve	VB
cord-292688-w4zvfkyl	112	23	the	the	DT
cord-292688-w4zvfkyl	112	24	function	function	NN
cord-292688-w4zvfkyl	112	25	of	of	IN
cord-292688-w4zvfkyl	112	26	selecting	select	VBG
cord-292688-w4zvfkyl	112	27	an	an	DT
cord-292688-w4zvfkyl	112	28	appropriate	appropriate	JJ
cord-292688-w4zvfkyl	112	29	membrane	membrane	NN
cord-292688-w4zvfkyl	112	30	for	for	IN
cord-292688-w4zvfkyl	112	31	the	the	DT
cord-292688-w4zvfkyl	112	32	nascent	nascent	JJ
cord-292688-w4zvfkyl	112	33	secretory	secretory	JJ
cord-292688-w4zvfkyl	112	34	granule	granule	NN
cord-292688-w4zvfkyl	112	35	.	.	.
cord-292688-w4zvfkyl	113	1	Indeed	indeed	RB
cord-292688-w4zvfkyl	113	2	,	,	,
cord-292688-w4zvfkyl	113	3	there	there	EX
cord-292688-w4zvfkyl	113	4	must	must	MD
cord-292688-w4zvfkyl	113	5	be	be	VB
cord-292688-w4zvfkyl	113	6	a	a	DT
cord-292688-w4zvfkyl	113	7	recognition	recognition	NN
cord-292688-w4zvfkyl	113	8	mechanism	mechanism	NN
cord-292688-w4zvfkyl	113	9	between	between	IN
cord-292688-w4zvfkyl	113	10	soluble	soluble	JJ
cord-292688-w4zvfkyl	113	11	granule	granule	NN
cord-292688-w4zvfkyl	113	12	proteins	protein	NNS
cord-292688-w4zvfkyl	113	13	and	and	CC
cord-292688-w4zvfkyl	113	14	granule	granule	NN
cord-292688-w4zvfkyl	113	15	membrane	membrane	NN
cord-292688-w4zvfkyl	113	16	proteins	protein	NNS
cord-292688-w4zvfkyl	113	17	or	or	CC
cord-292688-w4zvfkyl	113	18	components	component	NNS
cord-292688-w4zvfkyl	113	19	to	to	TO
cord-292688-w4zvfkyl	113	20	ensure	ensure	VB
cord-292688-w4zvfkyl	113	21	that	that	IN
cord-292688-w4zvfkyl	113	22	the	the	DT
cord-292688-w4zvfkyl	113	23	membrane	membrane	NN
cord-292688-w4zvfkyl	113	24	which	which	WDT
cord-292688-w4zvfkyl	113	25	¢nally	¢nally	RB
cord-292688-w4zvfkyl	113	26	envelops	envelop	VBZ
cord-292688-w4zvfkyl	113	27	the	the	DT
cord-292688-w4zvfkyl	113	28	dense	dense	JJ
cord-292688-w4zvfkyl	113	29	core	core	NN
cord-292688-w4zvfkyl	113	30	contains	contain	VBZ
cord-292688-w4zvfkyl	113	31	all	all	PDT
cord-292688-w4zvfkyl	113	32	the	the	DT
cord-292688-w4zvfkyl	113	33	proteins	protein	NNS
cord-292688-w4zvfkyl	113	34	necessary	necessary	JJ
cord-292688-w4zvfkyl	113	35	for	for	IN
cord-292688-w4zvfkyl	113	36	secretory	secretory	JJ
cord-292688-w4zvfkyl	113	37	granule	granule	NN
cord-292688-w4zvfkyl	113	38	maturation	maturation	NN
cord-292688-w4zvfkyl	113	39	,	,	,
cord-292688-w4zvfkyl	113	40	storage	storage	NN
cord-292688-w4zvfkyl	113	41	and	and	CC
cord-292688-w4zvfkyl	113	42	exocytosis	exocytosis	NN
cord-292688-w4zvfkyl	113	43	.	.	.
cord-292688-w4zvfkyl	114	1	Again	again	RB
cord-292688-w4zvfkyl	114	2	,	,	,
cord-292688-w4zvfkyl	114	3	it	-PRON-	PRP
cord-292688-w4zvfkyl	114	4	is	be	VBZ
cord-292688-w4zvfkyl	114	5	possible	possible	JJ
cord-292688-w4zvfkyl	114	6	that	that	IN
cord-292688-w4zvfkyl	114	7	this	this	DT
cord-292688-w4zvfkyl	114	8	selection	selection	NN
cord-292688-w4zvfkyl	114	9	only	only	RB
cord-292688-w4zvfkyl	114	10	occurs	occur	VBZ
cord-292688-w4zvfkyl	114	11	later	later	RB
cord-292688-w4zvfkyl	114	12	in	in	IN
cord-292688-w4zvfkyl	114	13	the	the	DT
cord-292688-w4zvfkyl	114	14	pathway	pathway	NN
cord-292688-w4zvfkyl	114	15	,	,	,
cord-292688-w4zvfkyl	114	16	in	in	IN
cord-292688-w4zvfkyl	114	17	the	the	DT
cord-292688-w4zvfkyl	114	18	ISG	ISG	NNP
cord-292688-w4zvfkyl	114	19	,	,	,
cord-292688-w4zvfkyl	114	20	and	and	CC
cord-292688-w4zvfkyl	114	21	that	that	IN
cord-292688-w4zvfkyl	114	22	the	the	DT
cord-292688-w4zvfkyl	114	23	proteins	protein	NNS
cord-292688-w4zvfkyl	114	24	not	not	RB
cord-292688-w4zvfkyl	114	25	required	require	VBN
cord-292688-w4zvfkyl	114	26	are	be	VBP
cord-292688-w4zvfkyl	114	27	removed	remove	VBN
cord-292688-w4zvfkyl	114	28	from	from	IN
cord-292688-w4zvfkyl	114	29	the	the	DT
cord-292688-w4zvfkyl	114	30	ISG	ISG	NNP
cord-292688-w4zvfkyl	114	31	instead	instead	RB
cord-292688-w4zvfkyl	114	32	of	of	IN
cord-292688-w4zvfkyl	114	33	being	be	VBG
cord-292688-w4zvfkyl	114	34	left	leave	VBN
cord-292688-w4zvfkyl	114	35	behind	behind	RB
cord-292688-w4zvfkyl	114	36	in	in	IN
cord-292688-w4zvfkyl	114	37	the	the	DT
cord-292688-w4zvfkyl	114	38	TGN	TGN	NNP
cord-292688-w4zvfkyl	114	39	.	.	.
cord-292688-w4zvfkyl	115	1	At	at	IN
cord-292688-w4zvfkyl	115	2	present	present	JJ
cord-292688-w4zvfkyl	115	3	we	-PRON-	PRP
cord-292688-w4zvfkyl	115	4	have	have	VBP
cord-292688-w4zvfkyl	115	5	very	very	RB
cord-292688-w4zvfkyl	115	6	little	little	JJ
cord-292688-w4zvfkyl	115	7	knowledge	knowledge	NN
cord-292688-w4zvfkyl	115	8	about	about	IN
cord-292688-w4zvfkyl	115	9	the	the	DT
cord-292688-w4zvfkyl	115	10	membrane	membrane	NN
cord-292688-w4zvfkyl	115	11	composition	composition	NN
cord-292688-w4zvfkyl	115	12	of	of	IN
cord-292688-w4zvfkyl	115	13	the	the	DT
cord-292688-w4zvfkyl	115	14	nascent	nascent	JJ
cord-292688-w4zvfkyl	115	15	ISG	ISG	NNP
cord-292688-w4zvfkyl	115	16	which	which	WDT
cord-292688-w4zvfkyl	115	17	would	would	MD
cord-292688-w4zvfkyl	115	18	allow	allow	VB
cord-292688-w4zvfkyl	115	19	one	one	PRP
cord-292688-w4zvfkyl	115	20	to	to	TO
cord-292688-w4zvfkyl	115	21	speculate	speculate	VB
cord-292688-w4zvfkyl	115	22	on	on	IN
cord-292688-w4zvfkyl	115	23	how	how	WRB
cord-292688-w4zvfkyl	115	24	and	and	CC
cord-292688-w4zvfkyl	115	25	where	where	WRB
cord-292688-w4zvfkyl	115	26	the	the	DT
cord-292688-w4zvfkyl	115	27	¢nal	¢nal	JJ
cord-292688-w4zvfkyl	115	28	selection	selection	NN
cord-292688-w4zvfkyl	115	29	is	be	VBZ
cord-292688-w4zvfkyl	115	30	achieved	achieve	VBN
cord-292688-w4zvfkyl	115	31	.	.	.
cord-292688-w4zvfkyl	116	1	Several	several	JJ
cord-292688-w4zvfkyl	116	2	years	year	NNS
cord-292688-w4zvfkyl	116	3	ago	ago	RB
cord-292688-w4zvfkyl	116	4	it	-PRON-	PRP
cord-292688-w4zvfkyl	116	5	was	be	VBD
cord-292688-w4zvfkyl	116	6	¢rst	¢rst	.
cord-292688-w4zvfkyl	116	7	shown	show	VBN
cord-292688-w4zvfkyl	116	8	that	that	IN
cord-292688-w4zvfkyl	116	9	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	116	10	cells	cell	NNS
cord-292688-w4zvfkyl	116	11	,	,	,
cord-292688-w4zvfkyl	116	12	which	which	WDT
cord-292688-w4zvfkyl	116	13	have	have	VBP
cord-292688-w4zvfkyl	116	14	a	a	DT
cord-292688-w4zvfkyl	116	15	regulated	regulate	VBN
cord-292688-w4zvfkyl	116	16	secretory	secretory	JJ
cord-292688-w4zvfkyl	116	17	pathway	pathway	NN
cord-292688-w4zvfkyl	116	18	,	,	,
cord-292688-w4zvfkyl	116	19	have	have	VBP
cord-292688-w4zvfkyl	116	20	a	a	DT
cord-292688-w4zvfkyl	116	21	distinct	distinct	JJ
cord-292688-w4zvfkyl	116	22	pathway	pathway	NN
cord-292688-w4zvfkyl	116	23	by	by	IN
cord-292688-w4zvfkyl	116	24	which	which	WDT
cord-292688-w4zvfkyl	116	25	they	-PRON-	PRP
cord-292688-w4zvfkyl	116	26	transport	transport	VBP
cord-292688-w4zvfkyl	116	27	proteins	protein	NNS
cord-292688-w4zvfkyl	116	28	to	to	IN
cord-292688-w4zvfkyl	116	29	the	the	DT
cord-292688-w4zvfkyl	116	30	plasma	plasma	NN
cord-292688-w4zvfkyl	116	31	membrane	membrane	NN
cord-292688-w4zvfkyl	116	32	,	,	,
cord-292688-w4zvfkyl	116	33	the	the	DT
cord-292688-w4zvfkyl	116	34	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	116	35	secretory	secretory	JJ
cord-292688-w4zvfkyl	116	36	pathway	pathway	NN
cord-292688-w4zvfkyl	116	37	[	[	-LRB-
cord-292688-w4zvfkyl	116	38	46	46	CD
cord-292688-w4zvfkyl	116	39	]	]	-RRB-
cord-292688-w4zvfkyl	116	40	.	.	.
cord-292688-w4zvfkyl	117	1	More	more	RBR
cord-292688-w4zvfkyl	117	2	recently	recently	RB
cord-292688-w4zvfkyl	117	3	,	,	,
cord-292688-w4zvfkyl	117	4	the	the	DT
cord-292688-w4zvfkyl	117	5	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	117	6	involved	involve	VBN
cord-292688-w4zvfkyl	117	7	in	in	IN
cord-292688-w4zvfkyl	117	8	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	117	9	secretion	secretion	NN
cord-292688-w4zvfkyl	117	10	of	of	IN
cord-292688-w4zvfkyl	117	11	proteins	protein	NNS
cord-292688-w4zvfkyl	117	12	from	from	IN
cord-292688-w4zvfkyl	117	13	PC12	pc12	JJ
cord-292688-w4zvfkyl	117	14	cells	cell	NNS
cord-292688-w4zvfkyl	117	15	,	,	,
cord-292688-w4zvfkyl	117	16	which	which	WDT
cord-292688-w4zvfkyl	117	17	also	also	RB
cord-292688-w4zvfkyl	117	18	have	have	VBP
cord-292688-w4zvfkyl	117	19	a	a	DT
cord-292688-w4zvfkyl	117	20	regulated	regulate	VBN
cord-292688-w4zvfkyl	117	21	secretory	secretory	JJ
cord-292688-w4zvfkyl	117	22	pathway	pathway	NN
cord-292688-w4zvfkyl	117	23	,	,	,
cord-292688-w4zvfkyl	117	24	have	have	VBP
cord-292688-w4zvfkyl	117	25	been	be	VBN
cord-292688-w4zvfkyl	117	26	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	117	27	[	[	-LRB-
cord-292688-w4zvfkyl	117	28	47	47	CD
cord-292688-w4zvfkyl	117	29	]	]	-RRB-
cord-292688-w4zvfkyl	117	30	.	.	.
cord-292688-w4zvfkyl	118	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	118	2	was	be	VBD
cord-292688-w4zvfkyl	118	3	shown	show	VBN
cord-292688-w4zvfkyl	118	4	in	in	IN
cord-292688-w4zvfkyl	118	5	PC12	pc12	JJ
cord-292688-w4zvfkyl	118	6	cells	cell	NNS
cord-292688-w4zvfkyl	118	7	,	,	,
cord-292688-w4zvfkyl	118	8	using	use	VBG
cord-292688-w4zvfkyl	118	9	two	two	CD
cord-292688-w4zvfkyl	118	10	sulphated	sulphate	VBN
cord-292688-w4zvfkyl	118	11	proteins	protein	NNS
cord-292688-w4zvfkyl	118	12	(	(	-LRB-
cord-292688-w4zvfkyl	118	13	a	a	DT
cord-292688-w4zvfkyl	118	14	hsPG	hspg	NN
cord-292688-w4zvfkyl	118	15	and	and	CC
cord-292688-w4zvfkyl	118	16	SgII	SgII	NNP
cord-292688-w4zvfkyl	118	17	)	)	-RRB-
cord-292688-w4zvfkyl	118	18	,	,	,
cord-292688-w4zvfkyl	118	19	as	as	IN
cord-292688-w4zvfkyl	118	20	markers	marker	NNS
cord-292688-w4zvfkyl	118	21	for	for	IN
cord-292688-w4zvfkyl	118	22	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	118	23	and	and	CC
cord-292688-w4zvfkyl	118	24	regulated	regulated	JJ
cord-292688-w4zvfkyl	118	25	pathways	pathway	NNS
cord-292688-w4zvfkyl	118	26	,	,	,
cord-292688-w4zvfkyl	118	27	respectively	respectively	RB
cord-292688-w4zvfkyl	118	28	,	,	,
cord-292688-w4zvfkyl	118	29	that	that	DT
cord-292688-w4zvfkyl	118	30	formation	formation	NN
cord-292688-w4zvfkyl	118	31	of	of	IN
cord-292688-w4zvfkyl	118	32	CSVs	csvs	NN
cord-292688-w4zvfkyl	118	33	occurs	occur	VBZ
cord-292688-w4zvfkyl	118	34	concomitantly	concomitantly	RB
cord-292688-w4zvfkyl	118	35	with	with	IN
cord-292688-w4zvfkyl	118	36	formation	formation	NN
cord-292688-w4zvfkyl	118	37	of	of	IN
cord-292688-w4zvfkyl	118	38	ISGs	ISGs	NNPS
cord-292688-w4zvfkyl	118	39	from	from	IN
cord-292688-w4zvfkyl	118	40	the	the	DT
cord-292688-w4zvfkyl	118	41	TGN	TGN	NNP
cord-292688-w4zvfkyl	118	42	.	.	.
cord-292688-w4zvfkyl	119	1	These	these	DT
cord-292688-w4zvfkyl	119	2	budding	budding	JJ
cord-292688-w4zvfkyl	119	3	reactions	reaction	NNS
cord-292688-w4zvfkyl	119	4	have	have	VBP
cord-292688-w4zvfkyl	119	5	very	very	RB
cord-292688-w4zvfkyl	119	6	similar	similar	JJ
cord-292688-w4zvfkyl	119	7	characteristics	characteristic	NNS
cord-292688-w4zvfkyl	119	8	to	to	IN
cord-292688-w4zvfkyl	119	9	those	those	DT
cord-292688-w4zvfkyl	119	10	described	describe	VBN
cord-292688-w4zvfkyl	119	11	below	below	RB
cord-292688-w4zvfkyl	119	12	for	for	IN
cord-292688-w4zvfkyl	119	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	119	14	granules	granule	NNS
cord-292688-w4zvfkyl	119	15	and	and	CC
cord-292688-w4zvfkyl	119	16	those	those	DT
cord-292688-w4zvfkyl	119	17	identi¢ed	identi¢ed	``
cord-292688-w4zvfkyl	119	18	using	use	VBG
cord-292688-w4zvfkyl	119	19	other	other	JJ
cord-292688-w4zvfkyl	119	20	systems	system	NNS
cord-292688-w4zvfkyl	119	21	which	which	WDT
cord-292688-w4zvfkyl	119	22	reconstitute	reconstitute	VBP
cord-292688-w4zvfkyl	119	23	vesicle	vesicle	NN
cord-292688-w4zvfkyl	119	24	formation	formation	NN
cord-292688-w4zvfkyl	119	25	from	from	IN
cord-292688-w4zvfkyl	119	26	cells	cell	NNS
cord-292688-w4zvfkyl	119	27	without	without	IN
cord-292688-w4zvfkyl	119	28	a	a	DT
cord-292688-w4zvfkyl	119	29	regulated	regulated	JJ
cord-292688-w4zvfkyl	119	30	pathway	pathway	NN
cord-292688-w4zvfkyl	119	31	(	(	-LRB-
cord-292688-w4zvfkyl	119	32	see	see	VB
cord-292688-w4zvfkyl	119	33	for	for	IN
cord-292688-w4zvfkyl	119	34	example	example	NN
cord-292688-w4zvfkyl	119	35	[	[	-LRB-
cord-292688-w4zvfkyl	119	36	48	48	CD
cord-292688-w4zvfkyl	119	37	]	]	-RRB-
cord-292688-w4zvfkyl	119	38	)	)	-RRB-
cord-292688-w4zvfkyl	119	39	.	.	.
cord-292688-w4zvfkyl	120	1	Formation	formation	NN
cord-292688-w4zvfkyl	120	2	of	of	IN
cord-292688-w4zvfkyl	120	3	CSVs	CSVs	NNP
cord-292688-w4zvfkyl	120	4	appears	appear	VBZ
cord-292688-w4zvfkyl	120	5	to	to	TO
cord-292688-w4zvfkyl	120	6	be	be	VB
cord-292688-w4zvfkyl	120	7	regulated	regulate	VBN
cord-292688-w4zvfkyl	120	8	by	by	IN
cord-292688-w4zvfkyl	120	9	heterotrimeric	heterotrimeric	NNP
cord-292688-w4zvfkyl	120	10	GTP	GTP	NNP
cord-292688-w4zvfkyl	120	11	-	-	HYPH
cord-292688-w4zvfkyl	120	12	binding	bind	VBG
cord-292688-w4zvfkyl	120	13	proteins	protein	NNS
cord-292688-w4zvfkyl	120	14	[	[	-LRB-
cord-292688-w4zvfkyl	120	15	49	49	CD
cord-292688-w4zvfkyl	120	16	,	,	,
cord-292688-w4zvfkyl	120	17	50	50	CD
cord-292688-w4zvfkyl	120	18	]	]	-RRB-
cord-292688-w4zvfkyl	120	19	,	,	,
cord-292688-w4zvfkyl	120	20	and	and	CC
cord-292688-w4zvfkyl	120	21	be	be	VB
cord-292688-w4zvfkyl	120	22	dependent	dependent	JJ
cord-292688-w4zvfkyl	120	23	upon	upon	IN
cord-292688-w4zvfkyl	120	24	ARF1	ARF1	NNP
cord-292688-w4zvfkyl	120	25	[	[	-LRB-
cord-292688-w4zvfkyl	120	26	51	51	CD
cord-292688-w4zvfkyl	120	27	,	,	,
cord-292688-w4zvfkyl	120	28	52	52	CD
cord-292688-w4zvfkyl	120	29	]	]	-RRB-
cord-292688-w4zvfkyl	120	30	.	.	.
cord-292688-w4zvfkyl	121	1	Although	although	IN
cord-292688-w4zvfkyl	121	2	the	the	DT
cord-292688-w4zvfkyl	121	3	¢delity	¢delity	NN
cord-292688-w4zvfkyl	121	4	of	of	IN
cord-292688-w4zvfkyl	121	5	sorting	sort	VBG
cord-292688-w4zvfkyl	121	6	into	into	IN
cord-292688-w4zvfkyl	121	7	the	the	DT
cord-292688-w4zvfkyl	121	8	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	121	9	and	and	CC
cord-292688-w4zvfkyl	121	10	regulated	regulated	JJ
cord-292688-w4zvfkyl	121	11	pathways	pathway	NNS
cord-292688-w4zvfkyl	121	12	appears	appear	VBZ
cord-292688-w4zvfkyl	121	13	to	to	TO
cord-292688-w4zvfkyl	121	14	vary	vary	VB
cord-292688-w4zvfkyl	121	15	in	in	IN
cord-292688-w4zvfkyl	121	16	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	121	17	PC12	PC12	NNP
cord-292688-w4zvfkyl	121	18	cells	cell	NNS
cord-292688-w4zvfkyl	121	19	clones	clone	NNS
cord-292688-w4zvfkyl	121	20	(	(	-LRB-
cord-292688-w4zvfkyl	121	21	compare	compare	VB
cord-292688-w4zvfkyl	121	22	[	[	-LRB-
cord-292688-w4zvfkyl	121	23	47	47	CD
cord-292688-w4zvfkyl	121	24	]	]	-RRB-
cord-292688-w4zvfkyl	121	25	and	and	CC
cord-292688-w4zvfkyl	121	26	[	[	-LRB-
cord-292688-w4zvfkyl	121	27	53	53	CD
cord-292688-w4zvfkyl	121	28	]	]	-RRB-
cord-292688-w4zvfkyl	121	29	)	)	-RRB-
cord-292688-w4zvfkyl	122	1	the	the	DT
cord-292688-w4zvfkyl	122	2	principle	principle	NN
cord-292688-w4zvfkyl	122	3	of	of	IN
cord-292688-w4zvfkyl	122	4	sorting	sort	VBG
cord-292688-w4zvfkyl	122	5	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	122	6	populations	population	NNS
cord-292688-w4zvfkyl	122	7	of	of	IN
cord-292688-w4zvfkyl	122	8	proteins	protein	NNS
cord-292688-w4zvfkyl	122	9	in	in	IN
cord-292688-w4zvfkyl	122	10	the	the	DT
cord-292688-w4zvfkyl	122	11	TGN	TGN	NNP
cord-292688-w4zvfkyl	122	12	into	into	IN
cord-292688-w4zvfkyl	122	13	distinct	distinct	JJ
cord-292688-w4zvfkyl	122	14	vesicle	vesicle	NN
cord-292688-w4zvfkyl	122	15	populations	population	NNS
cord-292688-w4zvfkyl	122	16	remains	remain	VBZ
cord-292688-w4zvfkyl	122	17	intact	intact	JJ
cord-292688-w4zvfkyl	122	18	in	in	IN
cord-292688-w4zvfkyl	122	19	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	122	20	cells	cell	NNS
cord-292688-w4zvfkyl	122	21	.	.	.
cord-292688-w4zvfkyl	123	1	In	in	IN
cord-292688-w4zvfkyl	123	2	contrast	contrast	NN
cord-292688-w4zvfkyl	123	3	,	,	,
cord-292688-w4zvfkyl	123	4	no	no	DT
cord-292688-w4zvfkyl	123	5	one	one	NN
cord-292688-w4zvfkyl	123	6	has	have	VBZ
cord-292688-w4zvfkyl	123	7	to	to	IN
cord-292688-w4zvfkyl	123	8	date	date	NN
cord-292688-w4zvfkyl	124	1	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	125	1	a	a	DT
cord-292688-w4zvfkyl	125	2	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	125	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	125	4	pathway	pathway	NN
cord-292688-w4zvfkyl	125	5	in	in	IN
cord-292688-w4zvfkyl	125	6	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	125	7	L	l	NN
cord-292688-w4zvfkyl	125	8	-	-	HYPH
cord-292688-w4zvfkyl	125	9	cells	cell	NNS
cord-292688-w4zvfkyl	125	10	using	use	VBG
cord-292688-w4zvfkyl	125	11	a	a	DT
cord-292688-w4zvfkyl	125	12	bone	bone	NN
cord-292688-w4zvfkyl	125	13	¢de	¢de	POS
cord-292688-w4zvfkyl	125	14	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	125	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	125	16	protein	protein	NN
cord-292688-w4zvfkyl	125	17	.	.	.
cord-292688-w4zvfkyl	126	1	The	the	DT
cord-292688-w4zvfkyl	126	2	C	c	NN
cord-292688-w4zvfkyl	126	3	-	-	HYPH
cord-292688-w4zvfkyl	126	4	peptide	peptide	NN
cord-292688-w4zvfkyl	126	5	,	,	,
cord-292688-w4zvfkyl	126	6	derived	derive	VBN
cord-292688-w4zvfkyl	126	7	from	from	IN
cord-292688-w4zvfkyl	126	8	processing	processing	NN
cord-292688-w4zvfkyl	126	9	of	of	IN
cord-292688-w4zvfkyl	126	10	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	126	11	,	,	,
cord-292688-w4zvfkyl	126	12	has	have	VBZ
cord-292688-w4zvfkyl	126	13	been	be	VBN
cord-292688-w4zvfkyl	126	14	shown	show	VBN
cord-292688-w4zvfkyl	126	15	to	to	TO
cord-292688-w4zvfkyl	126	16	be	be	VB
cord-292688-w4zvfkyl	126	17	secreted	secrete	VBN
cord-292688-w4zvfkyl	126	18	constitutively	constitutively	RB
cord-292688-w4zvfkyl	126	19	,	,	,
cord-292688-w4zvfkyl	126	20	however	however	RB
cord-292688-w4zvfkyl	126	21	,	,	,
cord-292688-w4zvfkyl	126	22	this	this	DT
cord-292688-w4zvfkyl	126	23	might	may	MD
cord-292688-w4zvfkyl	126	24	be	be	VB
cord-292688-w4zvfkyl	126	25	through	through	IN
cord-292688-w4zvfkyl	126	26	a	a	DT
cord-292688-w4zvfkyl	126	27	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	126	28	-	-	HYPH
cord-292688-w4zvfkyl	126	29	like	like	JJ
cord-292688-w4zvfkyl	126	30	pathway	pathway	NN
cord-292688-w4zvfkyl	126	31	originating	originate	VBG
cord-292688-w4zvfkyl	126	32	from	from	IN
cord-292688-w4zvfkyl	126	33	the	the	DT
cord-292688-w4zvfkyl	126	34	ISG	ISG	NNP
cord-292688-w4zvfkyl	126	35	[	[	-LRB-
cord-292688-w4zvfkyl	126	36	54	54	CD
cord-292688-w4zvfkyl	126	37	]	]	-RRB-
cord-292688-w4zvfkyl	126	38	.	.	.
cord-292688-w4zvfkyl	127	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	127	2	may	may	MD
cord-292688-w4zvfkyl	127	3	be	be	VB
cord-292688-w4zvfkyl	127	4	that	that	DT
cord-292688-w4zvfkyl	127	5	indeed	indeed	RB
cord-292688-w4zvfkyl	127	6	that	that	IN
cord-292688-w4zvfkyl	127	7	no	no	DT
cord-292688-w4zvfkyl	127	8	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	127	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	127	10	proteins	protein	NNS
cord-292688-w4zvfkyl	127	11	in	in	IN
cord-292688-w4zvfkyl	127	12	CSVs	csv	NNS
cord-292688-w4zvfkyl	127	13	are	be	VBP
cord-292688-w4zvfkyl	127	14	secreted	secrete	VBN
cord-292688-w4zvfkyl	127	15	directly	directly	RB
cord-292688-w4zvfkyl	127	16	from	from	IN
cord-292688-w4zvfkyl	127	17	the	the	DT
cord-292688-w4zvfkyl	127	18	TGN	TGN	NNP
cord-292688-w4zvfkyl	127	19	in	in	IN
cord-292688-w4zvfkyl	127	20	L	l	NN
cord-292688-w4zvfkyl	127	21	-	-	HYPH
cord-292688-w4zvfkyl	127	22	cells	cell	NNS
cord-292688-w4zvfkyl	127	23	,	,	,
cord-292688-w4zvfkyl	127	24	however	however	RB
cord-292688-w4zvfkyl	127	25	,	,	,
cord-292688-w4zvfkyl	127	26	using	use	VBG
cord-292688-w4zvfkyl	127	27	immunogold	immunogold	JJ
cord-292688-w4zvfkyl	127	28	labelling	labelling	NN
cord-292688-w4zvfkyl	127	29	techniques	technique	NNS
cord-292688-w4zvfkyl	127	30	CSVs	csv	NNS
cord-292688-w4zvfkyl	127	31	have	have	VBP
cord-292688-w4zvfkyl	127	32	been	be	VBN
cord-292688-w4zvfkyl	127	33	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	127	34	in	in	IN
cord-292688-w4zvfkyl	127	35	L	l	NN
cord-292688-w4zvfkyl	127	36	-	-	HYPH
cord-292688-w4zvfkyl	127	37	cells	cell	NNS
cord-292688-w4zvfkyl	127	38	using	use	VBG
cord-292688-w4zvfkyl	127	39	antibodies	antibody	NNS
cord-292688-w4zvfkyl	127	40	to	to	IN
cord-292688-w4zvfkyl	127	41	the	the	DT
cord-292688-w4zvfkyl	127	42	viral	viral	JJ
cord-292688-w4zvfkyl	127	43	-	-	HYPH
cord-292688-w4zvfkyl	127	44	spike	spike	NN
cord-292688-w4zvfkyl	127	45	glycoprotein	glycoprotein	NN
cord-292688-w4zvfkyl	127	46	HA	HA	NNP
cord-292688-w4zvfkyl	127	47	of	of	IN
cord-292688-w4zvfkyl	127	48	in£uenza	in£uenza	NNP
cord-292688-w4zvfkyl	127	49	virus	virus	NN
cord-292688-w4zvfkyl	127	50	[	[	-LRB-
cord-292688-w4zvfkyl	127	51	55	55	CD
cord-292688-w4zvfkyl	127	52	]	]	-RRB-
cord-292688-w4zvfkyl	127	53	.	.	.
cord-292688-w4zvfkyl	128	1	At	at	IN
cord-292688-w4zvfkyl	128	2	the	the	DT
cord-292688-w4zvfkyl	128	3	same	same	JJ
cord-292688-w4zvfkyl	128	4	time	time	NN
cord-292688-w4zvfkyl	128	5	,	,	,
cord-292688-w4zvfkyl	128	6	experiments	experiment	NNS
cord-292688-w4zvfkyl	128	7	were	be	VBD
cord-292688-w4zvfkyl	128	8	done	do	VBN
cord-292688-w4zvfkyl	128	9	which	which	WDT
cord-292688-w4zvfkyl	128	10	demonstrated	demonstrate	VBD
cord-292688-w4zvfkyl	128	11	that	that	IN
cord-292688-w4zvfkyl	128	12	corona	corona	NN
cord-292688-w4zvfkyl	128	13	virus	virus	NN
cord-292688-w4zvfkyl	128	14	virions	virion	NNS
cord-292688-w4zvfkyl	128	15	,	,	,
cord-292688-w4zvfkyl	128	16	which	which	WDT
cord-292688-w4zvfkyl	128	17	are	be	VBP
cord-292688-w4zvfkyl	128	18	released	release	VBN
cord-292688-w4zvfkyl	128	19	constitutively	constitutively	RB
cord-292688-w4zvfkyl	128	20	,	,	,
cord-292688-w4zvfkyl	128	21	were	be	VBD
cord-292688-w4zvfkyl	128	22	found	find	VBN
cord-292688-w4zvfkyl	128	23	segregated	segregate	VBN
cord-292688-w4zvfkyl	128	24	from	from	IN
cord-292688-w4zvfkyl	128	25	dense	dense	JJ
cord-292688-w4zvfkyl	128	26	-	-	HYPH
cord-292688-w4zvfkyl	128	27	cores	core	NNS
cord-292688-w4zvfkyl	128	28	in	in	IN
cord-292688-w4zvfkyl	128	29	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	128	30	cells	cell	NNS
cord-292688-w4zvfkyl	128	31	,	,	,
cord-292688-w4zvfkyl	128	32	a	a	DT
cord-292688-w4zvfkyl	128	33	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	128	34	cell	cell	NN
cord-292688-w4zvfkyl	128	35	line	line	NN
cord-292688-w4zvfkyl	128	36	[	[	-LRB-
cord-292688-w4zvfkyl	128	37	56	56	CD
cord-292688-w4zvfkyl	128	38	]	]	-RRB-
cord-292688-w4zvfkyl	128	39	.	.	.
cord-292688-w4zvfkyl	129	1	In	in	IN
cord-292688-w4zvfkyl	129	2	retrospect	retrospect	NN
cord-292688-w4zvfkyl	129	3	,	,	,
cord-292688-w4zvfkyl	129	4	the	the	DT
cord-292688-w4zvfkyl	129	5	ideal	ideal	JJ
cord-292688-w4zvfkyl	129	6	experiment	experiment	NN
cord-292688-w4zvfkyl	129	7	would	would	MD
cord-292688-w4zvfkyl	129	8	have	have	VB
cord-292688-w4zvfkyl	129	9	been	be	VBN
cord-292688-w4zvfkyl	129	10	to	to	TO
cord-292688-w4zvfkyl	129	11	study	study	VB
cord-292688-w4zvfkyl	129	12	the	the	DT
cord-292688-w4zvfkyl	129	13	transport	transport	NN
cord-292688-w4zvfkyl	129	14	of	of	IN
cord-292688-w4zvfkyl	129	15	coronavirus	coronavirus	NN
cord-292688-w4zvfkyl	129	16	particles	particle	NNS
cord-292688-w4zvfkyl	129	17	,	,	,
cord-292688-w4zvfkyl	129	18	which	which	WDT
cord-292688-w4zvfkyl	129	19	have	have	VBP
cord-292688-w4zvfkyl	129	20	the	the	DT
cord-292688-w4zvfkyl	129	21	advantage	advantage	NN
cord-292688-w4zvfkyl	129	22	of	of	IN
cord-292688-w4zvfkyl	129	23	being	be	VBG
cord-292688-w4zvfkyl	129	24	morphologically	morphologically	RB
cord-292688-w4zvfkyl	129	25	identi¢able	identi¢able	JJ
cord-292688-w4zvfkyl	129	26	marker	marker	NN
cord-292688-w4zvfkyl	129	27	for	for	IN
cord-292688-w4zvfkyl	129	28	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	129	29	secretion	secretion	NN
cord-292688-w4zvfkyl	129	30	,	,	,
cord-292688-w4zvfkyl	129	31	in	in	IN
cord-292688-w4zvfkyl	129	32	L	l	NN
cord-292688-w4zvfkyl	129	33	-	-	HYPH
cord-292688-w4zvfkyl	129	34	cells	cell	NNS
cord-292688-w4zvfkyl	129	35	.	.	.
cord-292688-w4zvfkyl	130	1	However	however	RB
cord-292688-w4zvfkyl	130	2	,	,	,
cord-292688-w4zvfkyl	130	3	in	in	IN
cord-292688-w4zvfkyl	130	4	the	the	DT
cord-292688-w4zvfkyl	130	5	absence	absence	NN
cord-292688-w4zvfkyl	130	6	of	of	IN
cord-292688-w4zvfkyl	130	7	experiments	experiment	NNS
cord-292688-w4zvfkyl	130	8	to	to	TO
cord-292688-w4zvfkyl	130	9	prove	prove	VB
cord-292688-w4zvfkyl	130	10	whether	whether	IN
cord-292688-w4zvfkyl	130	11	secretory	secretory	JJ
cord-292688-w4zvfkyl	130	12	proteins	protein	NNS
cord-292688-w4zvfkyl	130	13	are	be	VBP
cord-292688-w4zvfkyl	130	14	also	also	RB
cord-292688-w4zvfkyl	130	15	conveyed	convey	VBN
cord-292688-w4zvfkyl	130	16	by	by	IN
cord-292688-w4zvfkyl	130	17	this	this	DT
cord-292688-w4zvfkyl	130	18	pathway	pathway	NN
cord-292688-w4zvfkyl	130	19	,	,	,
cord-292688-w4zvfkyl	130	20	the	the	DT
cord-292688-w4zvfkyl	130	21	question	question	NN
cord-292688-w4zvfkyl	130	22	remains	remain	VBZ
cord-292688-w4zvfkyl	130	23	an	an	DT
cord-292688-w4zvfkyl	130	24	open	open	JJ
cord-292688-w4zvfkyl	130	25	one	one	CD
cord-292688-w4zvfkyl	130	26	.	.	.
cord-292688-w4zvfkyl	131	1	Transport	transport	NN
cord-292688-w4zvfkyl	131	2	of	of	IN
cord-292688-w4zvfkyl	131	3	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	131	4	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	131	5	from	from	IN
cord-292688-w4zvfkyl	131	6	the	the	DT
cord-292688-w4zvfkyl	131	7	TGN	TGN	NNP
cord-292688-w4zvfkyl	131	8	to	to	IN
cord-292688-w4zvfkyl	131	9	endosomes	endosome	NNS
cord-292688-w4zvfkyl	131	10	occurs	occur	VBZ
cord-292688-w4zvfkyl	131	11	via	via	IN
cord-292688-w4zvfkyl	131	12	clathrin	clathrin	NN
cord-292688-w4zvfkyl	131	13	-	-	HYPH
cord-292688-w4zvfkyl	131	14	coated	coat	VBN
cord-292688-w4zvfkyl	131	15	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	131	16	(	(	-LRB-
cord-292688-w4zvfkyl	131	17	CCVs	CCVs	NNP
cord-292688-w4zvfkyl	131	18	)	)	-RRB-
cord-292688-w4zvfkyl	131	19	,	,	,
cord-292688-w4zvfkyl	131	20	and	and	CC
cord-292688-w4zvfkyl	131	21	is	be	VBZ
cord-292688-w4zvfkyl	131	22	mediated	mediate	VBN
cord-292688-w4zvfkyl	131	23	by	by	IN
cord-292688-w4zvfkyl	131	24	binding	bind	VBG
cord-292688-w4zvfkyl	131	25	of	of	IN
cord-292688-w4zvfkyl	131	26	the	the	DT
cord-292688-w4zvfkyl	131	27	clathrincoat	clathrincoat	NN
cord-292688-w4zvfkyl	131	28	proteins	protein	NNS
cord-292688-w4zvfkyl	131	29	to	to	IN
cord-292688-w4zvfkyl	131	30	the	the	DT
cord-292688-w4zvfkyl	131	31	mannose-6-phosphate	mannose-6-phosphate	NNP
cord-292688-w4zvfkyl	131	32	receptor	receptor	NN
cord-292688-w4zvfkyl	131	33	(	(	-LRB-
cord-292688-w4zvfkyl	131	34	MPR	MPR	NNP
cord-292688-w4zvfkyl	131	35	,	,	,
cord-292688-w4zvfkyl	131	36	see	see	VB
cord-292688-w4zvfkyl	131	37	review	review	NN
cord-292688-w4zvfkyl	131	38	by	by	IN
cord-292688-w4zvfkyl	131	39	Ho£ack	Ho£ack	NNP
cord-292688-w4zvfkyl	131	40	in	in	IN
cord-292688-w4zvfkyl	131	41	this	this	DT
cord-292688-w4zvfkyl	131	42	issue	issue	NN
cord-292688-w4zvfkyl	131	43	)	)	-RRB-
cord-292688-w4zvfkyl	131	44	.	.	.
cord-292688-w4zvfkyl	132	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	132	2	has	have	VBZ
cord-292688-w4zvfkyl	132	3	been	be	VBN
cord-292688-w4zvfkyl	132	4	assumed	assume	VBN
cord-292688-w4zvfkyl	132	5	that	that	IN
cord-292688-w4zvfkyl	132	6	this	this	DT
cord-292688-w4zvfkyl	132	7	pathway	pathway	NN
cord-292688-w4zvfkyl	132	8	exists	exist	VBZ
cord-292688-w4zvfkyl	132	9	in	in	IN
cord-292688-w4zvfkyl	132	10	all	all	DT
cord-292688-w4zvfkyl	132	11	cells	cell	NNS
cord-292688-w4zvfkyl	132	12	.	.	.
cord-292688-w4zvfkyl	133	1	Clathrin	Clathrin	NNP
cord-292688-w4zvfkyl	133	2	coats	coat	NNS
cord-292688-w4zvfkyl	133	3	assemble	assemble	VBP
cord-292688-w4zvfkyl	133	4	on	on	IN
cord-292688-w4zvfkyl	133	5	the	the	DT
cord-292688-w4zvfkyl	133	6	TGN	TGN	NNP
cord-292688-w4zvfkyl	133	7	via	via	IN
cord-292688-w4zvfkyl	133	8	the	the	DT
cord-292688-w4zvfkyl	133	9	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	133	10	adaptor	adaptor	NN
cord-292688-w4zvfkyl	133	11	complex	complex	NN
cord-292688-w4zvfkyl	134	1	(	(	-LRB-
cord-292688-w4zvfkyl	134	2	Robinson	Robinson	NNP
cord-292688-w4zvfkyl	134	3	,	,	,
cord-292688-w4zvfkyl	134	4	this	this	DT
cord-292688-w4zvfkyl	134	5	issue	issue	NN
cord-292688-w4zvfkyl	134	6	)	)	-RRB-
cord-292688-w4zvfkyl	134	7	through	through	IN
cord-292688-w4zvfkyl	134	8	an	an	DT
cord-292688-w4zvfkyl	134	9	interaction	interaction	NN
cord-292688-w4zvfkyl	134	10	with	with	IN
cord-292688-w4zvfkyl	134	11	the	the	DT
cord-292688-w4zvfkyl	134	12	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	134	13	domain	domain	NN
cord-292688-w4zvfkyl	134	14	of	of	IN
cord-292688-w4zvfkyl	134	15	receptors	receptor	NNS
cord-292688-w4zvfkyl	134	16	,	,	,
cord-292688-w4zvfkyl	134	17	such	such	JJ
cord-292688-w4zvfkyl	134	18	as	as	IN
cord-292688-w4zvfkyl	134	19	MPR	MPR	NNP
cord-292688-w4zvfkyl	134	20	,	,	,
cord-292688-w4zvfkyl	134	21	and	and	CC
cord-292688-w4zvfkyl	134	22	other	other	JJ
cord-292688-w4zvfkyl	134	23	proteins	protein	NNS
cord-292688-w4zvfkyl	134	24	such	such	JJ
cord-292688-w4zvfkyl	134	25	as	as	IN
cord-292688-w4zvfkyl	134	26	furin	furin	NN
cord-292688-w4zvfkyl	134	27	which	which	WDT
cord-292688-w4zvfkyl	134	28	tra¤c	tra¤c	VBZ
cord-292688-w4zvfkyl	134	29	to	to	IN
cord-292688-w4zvfkyl	134	30	and	and	CC
cord-292688-w4zvfkyl	134	31	from	from	IN
cord-292688-w4zvfkyl	134	32	the	the	DT
cord-292688-w4zvfkyl	134	33	plasma	plasma	NN
cord-292688-w4zvfkyl	134	34	membrane	membrane	NN
cord-292688-w4zvfkyl	134	35	[	[	-LRB-
cord-292688-w4zvfkyl	134	36	57	57	CD
cord-292688-w4zvfkyl	134	37	^	^	SYM
cord-292688-w4zvfkyl	134	38	59	59	CD
cord-292688-w4zvfkyl	134	39	]	]	-RRB-
cord-292688-w4zvfkyl	134	40	.	.	.
cord-292688-w4zvfkyl	135	1	While	while	IN
cord-292688-w4zvfkyl	135	2	the	the	DT
cord-292688-w4zvfkyl	135	3	distribution	distribution	NN
cord-292688-w4zvfkyl	135	4	of	of	IN
cord-292688-w4zvfkyl	135	5	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	135	6	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	135	7	has	have	VBZ
cord-292688-w4zvfkyl	135	8	not	not	RB
cord-292688-w4zvfkyl	135	9	been	be	VBN
cord-292688-w4zvfkyl	135	10	studied	study	VBN
cord-292688-w4zvfkyl	135	11	in	in	IN
cord-292688-w4zvfkyl	135	12	PC12	PC12	NNP
cord-292688-w4zvfkyl	135	13	cells	cell	NNS
cord-292688-w4zvfkyl	135	14	,	,	,
cord-292688-w4zvfkyl	135	15	recent	recent	JJ
cord-292688-w4zvfkyl	135	16	data	datum	NNS
cord-292688-w4zvfkyl	135	17	using	use	VBG
cord-292688-w4zvfkyl	135	18	both	both	CC
cord-292688-w4zvfkyl	135	19	GH	GH	NNP
cord-292688-w4zvfkyl	135	20	4	4	CD
cord-292688-w4zvfkyl	135	21	C	c	NN
cord-292688-w4zvfkyl	135	22	1	1	CD
cord-292688-w4zvfkyl	135	23	cells	cell	NNS
cord-292688-w4zvfkyl	135	24	[	[	-LRB-
cord-292688-w4zvfkyl	135	25	60	60	CD
cord-292688-w4zvfkyl	135	26	]	]	-RRB-
cord-292688-w4zvfkyl	135	27	and	and	CC
cord-292688-w4zvfkyl	135	28	a	a	DT
cord-292688-w4zvfkyl	135	29	L	l	NN
cord-292688-w4zvfkyl	135	30	-	-	HYPH
cord-292688-w4zvfkyl	135	31	cell	cell	NN
cord-292688-w4zvfkyl	135	32	line	line	NN
cord-292688-w4zvfkyl	135	33	[	[	-LRB-
cord-292688-w4zvfkyl	135	34	26	26	CD
cord-292688-w4zvfkyl	135	35	]	]	-RRB-
cord-292688-w4zvfkyl	135	36	have	have	VBP
cord-292688-w4zvfkyl	135	37	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	135	38	that	that	IN
cord-292688-w4zvfkyl	135	39	some	some	DT
cord-292688-w4zvfkyl	135	40	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	135	41	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	135	42	are	be	VBP
cord-292688-w4zvfkyl	135	43	present	present	JJ
cord-292688-w4zvfkyl	135	44	in	in	IN
cord-292688-w4zvfkyl	135	45	ISGs	isg	NNS
cord-292688-w4zvfkyl	135	46	.	.	.
cord-292688-w4zvfkyl	136	1	The	the	DT
cord-292688-w4zvfkyl	136	2	appearance	appearance	NN
cord-292688-w4zvfkyl	136	3	of	of	IN
cord-292688-w4zvfkyl	136	4	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	136	5	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	136	6	in	in	IN
cord-292688-w4zvfkyl	136	7	the	the	DT
cord-292688-w4zvfkyl	136	8	regulated	regulated	JJ
cord-292688-w4zvfkyl	136	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	136	10	pathway	pathway	NN
cord-292688-w4zvfkyl	136	11	provides	provide	VBZ
cord-292688-w4zvfkyl	136	12	additional	additional	JJ
cord-292688-w4zvfkyl	136	13	support	support	NN
cord-292688-w4zvfkyl	136	14	for	for	IN
cord-292688-w4zvfkyl	136	15	the`sorting	the`sorting	NNP
cord-292688-w4zvfkyl	137	1	by	by	IN
cord-292688-w4zvfkyl	137	2	retention	retention	NN
cord-292688-w4zvfkyl	137	3	'	'	''
cord-292688-w4zvfkyl	137	4	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	137	5	.	.	.
cord-292688-w4zvfkyl	138	1	These	these	DT
cord-292688-w4zvfkyl	138	2	authors	author	NNS
cord-292688-w4zvfkyl	138	3	[	[	-LRB-
cord-292688-w4zvfkyl	138	4	26	26	CD
cord-292688-w4zvfkyl	138	5	,	,	,
cord-292688-w4zvfkyl	138	6	60	60	CD
cord-292688-w4zvfkyl	138	7	]	]	-RRB-
cord-292688-w4zvfkyl	138	8	were	be	VBD
cord-292688-w4zvfkyl	138	9	able	able	JJ
cord-292688-w4zvfkyl	138	10	to	to	TO
cord-292688-w4zvfkyl	138	11	demonstrate	demonstrate	VB
cord-292688-w4zvfkyl	138	12	that	that	IN
cord-292688-w4zvfkyl	138	13	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	138	14	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	138	15	can	can	MD
cord-292688-w4zvfkyl	138	16	be	be	VB
cord-292688-w4zvfkyl	138	17	released	release	VBN
cord-292688-w4zvfkyl	138	18	from	from	IN
cord-292688-w4zvfkyl	138	19	the	the	DT
cord-292688-w4zvfkyl	138	20	cells	cell	NNS
cord-292688-w4zvfkyl	138	21	by	by	IN
cord-292688-w4zvfkyl	138	22	agents	agent	NNS
cord-292688-w4zvfkyl	138	23	used	use	VBN
cord-292688-w4zvfkyl	138	24	to	to	TO
cord-292688-w4zvfkyl	138	25	stimulate	stimulate	VB
cord-292688-w4zvfkyl	138	26	regulated	regulated	JJ
cord-292688-w4zvfkyl	138	27	secretion	secretion	NN
cord-292688-w4zvfkyl	138	28	.	.	.
cord-292688-w4zvfkyl	139	1	Some	some	DT
cord-292688-w4zvfkyl	139	2	of	of	IN
cord-292688-w4zvfkyl	139	3	the	the	DT
cord-292688-w4zvfkyl	139	4	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	139	5	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	139	6	(	(	-LRB-
cord-292688-w4zvfkyl	139	7	cathepsin	cathepsin	NN
cord-292688-w4zvfkyl	139	8	B	b	NN
cord-292688-w4zvfkyl	139	9	)	)	-RRB-
cord-292688-w4zvfkyl	139	10	were	be	VBD
cord-292688-w4zvfkyl	139	11	absent	absent	JJ
cord-292688-w4zvfkyl	139	12	from	from	IN
cord-292688-w4zvfkyl	139	13	the	the	DT
cord-292688-w4zvfkyl	139	14	MSG	MSG	NNP
cord-292688-w4zvfkyl	139	15	,	,	,
cord-292688-w4zvfkyl	139	16	while	while	IN
cord-292688-w4zvfkyl	139	17	others	other	NNS
cord-292688-w4zvfkyl	139	18	(	(	-LRB-
cord-292688-w4zvfkyl	139	19	cathepsin	cathepsin	NN
cord-292688-w4zvfkyl	139	20	L	l	NN
cord-292688-w4zvfkyl	139	21	)	)	-RRB-
cord-292688-w4zvfkyl	139	22	were	be	VBD
cord-292688-w4zvfkyl	139	23	detected	detect	VBN
cord-292688-w4zvfkyl	139	24	in	in	IN
cord-292688-w4zvfkyl	139	25	MSGs	msg	NNS
cord-292688-w4zvfkyl	139	26	[	[	-LRB-
cord-292688-w4zvfkyl	139	27	30	30	CD
cord-292688-w4zvfkyl	139	28	]	]	-RRB-
cord-292688-w4zvfkyl	139	29	.	.	.
cord-292688-w4zvfkyl	140	1	These	these	DT
cord-292688-w4zvfkyl	140	2	results	result	NNS
cord-292688-w4zvfkyl	140	3	suggest	suggest	VBP
cord-292688-w4zvfkyl	140	4	that	that	IN
cord-292688-w4zvfkyl	140	5	in	in	IN
cord-292688-w4zvfkyl	140	6	the	the	DT
cord-292688-w4zvfkyl	140	7	TGN	TGN	NNP
cord-292688-w4zvfkyl	140	8	newly	newly	RB
cord-292688-w4zvfkyl	140	9	synthesized	synthesize	VBN
cord-292688-w4zvfkyl	140	10	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	140	11	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	140	12	are	be	VBP
cord-292688-w4zvfkyl	140	13	incorporated	incorporate	VBN
cord-292688-w4zvfkyl	140	14	into	into	IN
cord-292688-w4zvfkyl	140	15	the	the	DT
cord-292688-w4zvfkyl	140	16	nascent	nascent	JJ
cord-292688-w4zvfkyl	140	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	140	18	granule	granule	NN
cord-292688-w4zvfkyl	140	19	.	.	.
cord-292688-w4zvfkyl	141	1	This	this	DT
cord-292688-w4zvfkyl	141	2	could	could	MD
cord-292688-w4zvfkyl	141	3	be	be	VB
cord-292688-w4zvfkyl	141	4	due	due	JJ
cord-292688-w4zvfkyl	141	5	to	to	IN
cord-292688-w4zvfkyl	141	6	a	a	DT
cord-292688-w4zvfkyl	141	7	missorting	missorting	NN
cord-292688-w4zvfkyl	141	8	of	of	IN
cord-292688-w4zvfkyl	141	9	the	the	DT
cord-292688-w4zvfkyl	141	10	receptors	receptor	NNS
cord-292688-w4zvfkyl	141	11	for	for	IN
cord-292688-w4zvfkyl	141	12	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	141	13	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	141	14	,	,	,
cord-292688-w4zvfkyl	141	15	MPR	MPR	NNP
cord-292688-w4zvfkyl	141	16	,	,	,
cord-292688-w4zvfkyl	141	17	into	into	IN
cord-292688-w4zvfkyl	141	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	141	19	granules	granule	NNS
cord-292688-w4zvfkyl	141	20	.	.	.
cord-292688-w4zvfkyl	142	1	However	however	RB
cord-292688-w4zvfkyl	142	2	,	,	,
cord-292688-w4zvfkyl	142	3	newly	newly	RB
cord-292688-w4zvfkyl	142	4	synthesized	synthesize	VBN
cord-292688-w4zvfkyl	142	5	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	142	6	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	142	7	that	that	WDT
cord-292688-w4zvfkyl	142	8	have	have	VBP
cord-292688-w4zvfkyl	142	9	diminished	diminish	VBN
cord-292688-w4zvfkyl	142	10	or	or	CC
cord-292688-w4zvfkyl	142	11	abolished	abolish	VBN
cord-292688-w4zvfkyl	142	12	a¤nity	a¤nity	NN
cord-292688-w4zvfkyl	142	13	for	for	IN
cord-292688-w4zvfkyl	142	14	MPRs	mpr	NNS
cord-292688-w4zvfkyl	142	15	continue	continue	VBP
cord-292688-w4zvfkyl	142	16	to	to	TO
cord-292688-w4zvfkyl	142	17	enter	enter	VB
cord-292688-w4zvfkyl	142	18	ISGs	isg	NNS
cord-292688-w4zvfkyl	142	19	in	in	IN
cord-292688-w4zvfkyl	142	20	equal	equal	JJ
cord-292688-w4zvfkyl	142	21	or	or	CC
cord-292688-w4zvfkyl	142	22	even	even	RB
cord-292688-w4zvfkyl	142	23	greater	great	JJR
cord-292688-w4zvfkyl	142	24	abundance	abundance	NN
cord-292688-w4zvfkyl	142	25	[	[	-LRB-
cord-292688-w4zvfkyl	142	26	26	26	CD
cord-292688-w4zvfkyl	142	27	,	,	,
cord-292688-w4zvfkyl	142	28	30	30	CD
cord-292688-w4zvfkyl	142	29	]	]	-RRB-
cord-292688-w4zvfkyl	142	30	.	.	.
cord-292688-w4zvfkyl	143	1	As	as	IN
cord-292688-w4zvfkyl	143	2	an	an	DT
cord-292688-w4zvfkyl	143	3	alternative	alternative	JJ
cord-292688-w4zvfkyl	143	4	explanation	explanation	NN
cord-292688-w4zvfkyl	143	5	,	,	,
cord-292688-w4zvfkyl	143	6	there	there	EX
cord-292688-w4zvfkyl	143	7	may	may	MD
cord-292688-w4zvfkyl	143	8	be	be	VB
cord-292688-w4zvfkyl	143	9	a	a	DT
cord-292688-w4zvfkyl	143	10	decrease	decrease	NN
cord-292688-w4zvfkyl	143	11	in	in	IN
cord-292688-w4zvfkyl	143	12	the	the	DT
cord-292688-w4zvfkyl	143	13	e¤ciency	e¤ciency	NN
cord-292688-w4zvfkyl	143	14	of	of	IN
cord-292688-w4zvfkyl	143	15	sorting	sorting	NN
cord-292688-w4zvfkyl	143	16	of	of	IN
cord-292688-w4zvfkyl	143	17	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	143	18	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	143	19	by	by	IN
cord-292688-w4zvfkyl	143	20	the	the	DT
cord-292688-w4zvfkyl	143	21	MPRs	MPRs	NNPS
cord-292688-w4zvfkyl	143	22	in	in	IN
cord-292688-w4zvfkyl	143	23	the	the	DT
cord-292688-w4zvfkyl	143	24	TGN	TGN	NNP
cord-292688-w4zvfkyl	143	25	of	of	IN
cord-292688-w4zvfkyl	143	26	cells	cell	NNS
cord-292688-w4zvfkyl	143	27	with	with	IN
cord-292688-w4zvfkyl	143	28	a	a	DT
cord-292688-w4zvfkyl	143	29	regulated	regulated	JJ
cord-292688-w4zvfkyl	143	30	secretory	secretory	JJ
cord-292688-w4zvfkyl	143	31	pathway	pathway	NN
cord-292688-w4zvfkyl	143	32	which	which	WDT
cord-292688-w4zvfkyl	143	33	allows	allow	VBZ
cord-292688-w4zvfkyl	143	34	them	-PRON-	PRP
cord-292688-w4zvfkyl	143	35	to	to	TO
cord-292688-w4zvfkyl	143	36	escape	escape	VB
cord-292688-w4zvfkyl	143	37	from	from	IN
cord-292688-w4zvfkyl	143	38	the	the	DT
cord-292688-w4zvfkyl	143	39	TGN	TGN	NNP
cord-292688-w4zvfkyl	143	40	in	in	IN
cord-292688-w4zvfkyl	143	41	other	other	JJ
cord-292688-w4zvfkyl	143	42	exit	exit	NN
cord-292688-w4zvfkyl	143	43	pathways	pathway	NNS
cord-292688-w4zvfkyl	143	44	,	,	,
cord-292688-w4zvfkyl	143	45	such	such	JJ
cord-292688-w4zvfkyl	143	46	as	as	IN
cord-292688-w4zvfkyl	143	47	the	the	DT
cord-292688-w4zvfkyl	143	48	regulated	regulated	JJ
cord-292688-w4zvfkyl	143	49	or	or	CC
cord-292688-w4zvfkyl	143	50	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	143	51	secretory	secretory	JJ
cord-292688-w4zvfkyl	143	52	pathway	pathway	NN
cord-292688-w4zvfkyl	143	53	,	,	,
cord-292688-w4zvfkyl	143	54	and	and	CC
cord-292688-w4zvfkyl	143	55	be	be	VB
cord-292688-w4zvfkyl	143	56	secreted	secrete	VBN
cord-292688-w4zvfkyl	143	57	or	or	CC
cord-292688-w4zvfkyl	143	58	recaptured	recapture	VBN
cord-292688-w4zvfkyl	143	59	at	at	IN
cord-292688-w4zvfkyl	143	60	a	a	DT
cord-292688-w4zvfkyl	143	61	post	post	JJ
cord-292688-w4zvfkyl	143	62	-	-	JJ
cord-292688-w4zvfkyl	143	63	Golgi	golgi	JJ
cord-292688-w4zvfkyl	143	64	location	location	NN
cord-292688-w4zvfkyl	143	65	such	such	JJ
cord-292688-w4zvfkyl	143	66	as	as	IN
cord-292688-w4zvfkyl	143	67	the	the	DT
cord-292688-w4zvfkyl	143	68	endosome	endosome	NN
cord-292688-w4zvfkyl	143	69	(	(	-LRB-
cord-292688-w4zvfkyl	143	70	see	see	VB
cord-292688-w4zvfkyl	143	71	review	review	NN
cord-292688-w4zvfkyl	143	72	[	[	-LRB-
cord-292688-w4zvfkyl	143	73	61	61	CD
cord-292688-w4zvfkyl	143	74	]	]	-RRB-
cord-292688-w4zvfkyl	143	75	)	)	-RRB-
cord-292688-w4zvfkyl	143	76	.	.	.
cord-292688-w4zvfkyl	144	1	A	a	DT
cord-292688-w4zvfkyl	144	2	variety	variety	NN
cord-292688-w4zvfkyl	144	3	of	of	IN
cord-292688-w4zvfkyl	144	4	experiments	experiment	NNS
cord-292688-w4zvfkyl	144	5	,	,	,
cord-292688-w4zvfkyl	144	6	including	include	VBG
cord-292688-w4zvfkyl	144	7	those	those	DT
cord-292688-w4zvfkyl	144	8	cited	cite	VBN
cord-292688-w4zvfkyl	144	9	above	above	RB
cord-292688-w4zvfkyl	144	10	,	,	,
cord-292688-w4zvfkyl	144	11	have	have	VBP
cord-292688-w4zvfkyl	144	12	con¢rmed	con¢rme	VBN
cord-292688-w4zvfkyl	144	13	the	the	DT
cord-292688-w4zvfkyl	144	14	transient	transient	JJ
cord-292688-w4zvfkyl	144	15	appearance	appearance	NN
cord-292688-w4zvfkyl	144	16	of	of	IN
cord-292688-w4zvfkyl	144	17	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	144	18	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	144	19	in	in	IN
cord-292688-w4zvfkyl	144	20	the	the	DT
cord-292688-w4zvfkyl	144	21	regulated	regulated	JJ
cord-292688-w4zvfkyl	144	22	pathway	pathway	NN
cord-292688-w4zvfkyl	144	23	,	,	,
cord-292688-w4zvfkyl	144	24	suggesting	suggest	VBG
cord-292688-w4zvfkyl	144	25	that	that	IN
cord-292688-w4zvfkyl	144	26	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	144	27	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	144	28	are	be	VBP
cord-292688-w4zvfkyl	144	29	being	be	VBG
cord-292688-w4zvfkyl	144	30	removed	remove	VBN
cord-292688-w4zvfkyl	144	31	from	from	IN
cord-292688-w4zvfkyl	144	32	the	the	DT
cord-292688-w4zvfkyl	144	33	maturing	mature	VBG
cord-292688-w4zvfkyl	144	34	ISGs	isg	NNS
cord-292688-w4zvfkyl	144	35	.	.	.
cord-292688-w4zvfkyl	145	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	145	2	is	be	VBZ
cord-292688-w4zvfkyl	145	3	assumed	assume	VBN
cord-292688-w4zvfkyl	145	4	that	that	IN
cord-292688-w4zvfkyl	145	5	this	this	DT
cord-292688-w4zvfkyl	145	6	is	be	VBZ
cord-292688-w4zvfkyl	145	7	occurs	occur	VBZ
cord-292688-w4zvfkyl	145	8	via	via	IN
cord-292688-w4zvfkyl	145	9	the	the	DT
cord-292688-w4zvfkyl	145	10	MPR	MPR	NNP
cord-292688-w4zvfkyl	145	11	and	and	CC
cord-292688-w4zvfkyl	145	12	CCVs	ccv	NNS
cord-292688-w4zvfkyl	145	13	.	.	.
cord-292688-w4zvfkyl	146	1	Indeed	indeed	RB
cord-292688-w4zvfkyl	146	2	,	,	,
cord-292688-w4zvfkyl	146	3	this	this	DT
cord-292688-w4zvfkyl	146	4	may	may	MD
cord-292688-w4zvfkyl	146	5	explain	explain	VB
cord-292688-w4zvfkyl	146	6	the	the	DT
cord-292688-w4zvfkyl	146	7	transient	transient	JJ
cord-292688-w4zvfkyl	146	8	presence	presence	NN
cord-292688-w4zvfkyl	146	9	of	of	IN
cord-292688-w4zvfkyl	146	10	clathrin	clathrin	NN
cord-292688-w4zvfkyl	146	11	coats	coat	NNS
cord-292688-w4zvfkyl	146	12	on	on	IN
cord-292688-w4zvfkyl	146	13	the	the	DT
cord-292688-w4zvfkyl	146	14	ISGs	isg	NNS
cord-292688-w4zvfkyl	146	15	.	.	.
cord-292688-w4zvfkyl	147	1	Further	further	JJ
cord-292688-w4zvfkyl	147	2	support	support	NN
cord-292688-w4zvfkyl	147	3	for	for	IN
cord-292688-w4zvfkyl	147	4	this	this	DT
cord-292688-w4zvfkyl	147	5	idea	idea	NN
cord-292688-w4zvfkyl	147	6	comes	come	VBZ
cord-292688-w4zvfkyl	147	7	from	from	IN
cord-292688-w4zvfkyl	147	8	experiments	experiment	NNS
cord-292688-w4zvfkyl	147	9	which	which	WDT
cord-292688-w4zvfkyl	147	10	show	show	VBP
cord-292688-w4zvfkyl	147	11	that	that	IN
cord-292688-w4zvfkyl	147	12	the	the	DT
cord-292688-w4zvfkyl	147	13	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	147	14	is	be	VBZ
cord-292688-w4zvfkyl	147	15	used	use	VBN
cord-292688-w4zvfkyl	147	16	on	on	IN
cord-292688-w4zvfkyl	147	17	the	the	DT
cord-292688-w4zvfkyl	147	18	ISG	ISG	NNP
cord-292688-w4zvfkyl	147	19	to	to	TO
cord-292688-w4zvfkyl	147	20	assemble	assemble	VB
cord-292688-w4zvfkyl	147	21	the	the	DT
cord-292688-w4zvfkyl	147	22	clathrin	clathrin	NN
cord-292688-w4zvfkyl	147	23	coat	coat	NN
cord-292688-w4zvfkyl	147	24	[	[	-LRB-
cord-292688-w4zvfkyl	147	25	62	62	CD
cord-292688-w4zvfkyl	147	26	]	]	-RRB-
cord-292688-w4zvfkyl	147	27	,	,	,
cord-292688-w4zvfkyl	147	28	and	and	CC
cord-292688-w4zvfkyl	147	29	the	the	DT
cord-292688-w4zvfkyl	147	30	MPR	MPR	NNP
cord-292688-w4zvfkyl	147	31	has	have	VBZ
cord-292688-w4zvfkyl	147	32	been	be	VBN
cord-292688-w4zvfkyl	147	33	found	find	VBN
cord-292688-w4zvfkyl	147	34	in	in	IN
cord-292688-w4zvfkyl	147	35	ISGs	isg	NNS
cord-292688-w4zvfkyl	147	36	but	but	CC
cord-292688-w4zvfkyl	147	37	not	not	RB
cord-292688-w4zvfkyl	147	38	MSGs	msg	NNS
cord-292688-w4zvfkyl	147	39	in	in	IN
cord-292688-w4zvfkyl	147	40	isolated	isolate	VBN
cord-292688-w4zvfkyl	147	41	secretory	secretory	JJ
cord-292688-w4zvfkyl	147	42	granule	granule	NN
cord-292688-w4zvfkyl	147	43	fractions	fraction	NNS
cord-292688-w4zvfkyl	147	44	derived	derive	VBN
cord-292688-w4zvfkyl	147	45	from	from	IN
cord-292688-w4zvfkyl	147	46	PC12	pc12	JJ
cord-292688-w4zvfkyl	147	47	cells	cell	NNS
cord-292688-w4zvfkyl	147	48	(	(	-LRB-
cord-292688-w4zvfkyl	147	49	A.S.	A.S.	NNP
cord-292688-w4zvfkyl	147	50	Dittië	Dittië	NNP
cord-292688-w4zvfkyl	147	51	,	,	,
cord-292688-w4zvfkyl	147	52	submitted	submit	VBD
cord-292688-w4zvfkyl	147	53	)	)	-RRB-
cord-292688-w4zvfkyl	147	54	.	.	.
cord-292688-w4zvfkyl	148	1	A	a	DT
cord-292688-w4zvfkyl	148	2	second	second	JJ
cord-292688-w4zvfkyl	148	3	protein	protein	NN
cord-292688-w4zvfkyl	148	4	which	which	WDT
cord-292688-w4zvfkyl	148	5	is	be	VBZ
cord-292688-w4zvfkyl	148	6	involved	involve	VBN
cord-292688-w4zvfkyl	148	7	in	in	IN
cord-292688-w4zvfkyl	148	8	recruiting	recruit	VBG
cord-292688-w4zvfkyl	148	9	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	148	10	and	and	CC
cord-292688-w4zvfkyl	148	11	therefore	therefore	RB
cord-292688-w4zvfkyl	148	12	clathrin	clathrin	VB
cord-292688-w4zvfkyl	148	13	onto	onto	IN
cord-292688-w4zvfkyl	148	14	ISGs	isg	NNS
cord-292688-w4zvfkyl	148	15	is	be	VBZ
cord-292688-w4zvfkyl	148	16	furin	furin	NN
cord-292688-w4zvfkyl	148	17	,	,	,
cord-292688-w4zvfkyl	148	18	an	an	DT
cord-292688-w4zvfkyl	148	19	endopeptidase	endopeptidase	NN
cord-292688-w4zvfkyl	148	20	present	present	JJ
cord-292688-w4zvfkyl	148	21	in	in	IN
cord-292688-w4zvfkyl	148	22	TGN	TGN	NNP
cord-292688-w4zvfkyl	148	23	membranes	membrane	NNS
cord-292688-w4zvfkyl	148	24	.	.	.
cord-292688-w4zvfkyl	149	1	Furin	Furin	NNP
cord-292688-w4zvfkyl	149	2	,	,	,
cord-292688-w4zvfkyl	149	3	like	like	IN
cord-292688-w4zvfkyl	149	4	MPR	MPR	NNP
cord-292688-w4zvfkyl	149	5	,	,	,
cord-292688-w4zvfkyl	149	6	is	be	VBZ
cord-292688-w4zvfkyl	149	7	found	find	VBN
cord-292688-w4zvfkyl	149	8	in	in	IN
cord-292688-w4zvfkyl	149	9	ISGs	isg	NNS
cord-292688-w4zvfkyl	149	10	but	but	CC
cord-292688-w4zvfkyl	149	11	not	not	RB
cord-292688-w4zvfkyl	149	12	MSGs	msg	NNS
cord-292688-w4zvfkyl	149	13	[	[	-LRB-
cord-292688-w4zvfkyl	149	14	63	63	CD
cord-292688-w4zvfkyl	149	15	]	]	-RRB-
cord-292688-w4zvfkyl	149	16	.	.	.
cord-292688-w4zvfkyl	150	1	These	these	DT
cord-292688-w4zvfkyl	150	2	results	result	NNS
cord-292688-w4zvfkyl	150	3	suggest	suggest	VBP
cord-292688-w4zvfkyl	150	4	that	that	IN
cord-292688-w4zvfkyl	150	5	furin	furin	NN
cord-292688-w4zvfkyl	150	6	,	,	,
cord-292688-w4zvfkyl	150	7	like	like	IN
cord-292688-w4zvfkyl	150	8	MPR	MPR	NNP
cord-292688-w4zvfkyl	150	9	,	,	,
cord-292688-w4zvfkyl	150	10	is	be	VBZ
cord-292688-w4zvfkyl	150	11	removed	remove	VBN
cord-292688-w4zvfkyl	150	12	from	from	IN
cord-292688-w4zvfkyl	150	13	the	the	DT
cord-292688-w4zvfkyl	150	14	ISG	ISG	NNP
cord-292688-w4zvfkyl	150	15	via	via	IN
cord-292688-w4zvfkyl	150	16	CCVs	ccv	NNS
cord-292688-w4zvfkyl	150	17	.	.	.
cord-292688-w4zvfkyl	151	1	The	the	DT
cord-292688-w4zvfkyl	151	2	destination	destination	NN
cord-292688-w4zvfkyl	151	3	of	of	IN
cord-292688-w4zvfkyl	151	4	the	the	DT
cord-292688-w4zvfkyl	151	5	CCVs	ccv	NNS
cord-292688-w4zvfkyl	151	6	,	,	,
cord-292688-w4zvfkyl	151	7	containing	contain	VBG
cord-292688-w4zvfkyl	151	8	either	either	CC
cord-292688-w4zvfkyl	151	9	furin	furin	NN
cord-292688-w4zvfkyl	151	10	,	,	,
cord-292688-w4zvfkyl	151	11	MPR	MPR	NNP
cord-292688-w4zvfkyl	151	12	,	,	,
cord-292688-w4zvfkyl	151	13	or	or	CC
cord-292688-w4zvfkyl	151	14	both	both	DT
cord-292688-w4zvfkyl	151	15	,	,	,
cord-292688-w4zvfkyl	151	16	could	could	MD
cord-292688-w4zvfkyl	151	17	be	be	VB
cord-292688-w4zvfkyl	151	18	any	any	DT
cord-292688-w4zvfkyl	151	19	one	one	CD
cord-292688-w4zvfkyl	151	20	of	of	IN
cord-292688-w4zvfkyl	151	21	several	several	JJ
cord-292688-w4zvfkyl	151	22	possibilities	possibility	NNS
cord-292688-w4zvfkyl	151	23	,	,	,
cord-292688-w4zvfkyl	151	24	for	for	IN
cord-292688-w4zvfkyl	151	25	example	example	NN
cord-292688-w4zvfkyl	151	26	,	,	,
cord-292688-w4zvfkyl	151	27	the	the	DT
cord-292688-w4zvfkyl	151	28	TGN	TGN	NNP
cord-292688-w4zvfkyl	151	29	,	,	,
cord-292688-w4zvfkyl	151	30	early	early	JJ
cord-292688-w4zvfkyl	151	31	endosomes	endosome	NNS
cord-292688-w4zvfkyl	151	32	,	,	,
cord-292688-w4zvfkyl	151	33	or	or	CC
cord-292688-w4zvfkyl	151	34	plasma	plasma	NN
cord-292688-w4zvfkyl	151	35	membrane	membrane	NN
cord-292688-w4zvfkyl	151	36	.	.	.
cord-292688-w4zvfkyl	152	1	There	there	EX
cord-292688-w4zvfkyl	152	2	is	be	VBZ
cord-292688-w4zvfkyl	152	3	no	no	DT
cord-292688-w4zvfkyl	152	4	data	data	NN
cord-292688-w4zvfkyl	152	5	at	at	IN
cord-292688-w4zvfkyl	152	6	present	present	NN
cord-292688-w4zvfkyl	152	7	regarding	regard	VBG
cord-292688-w4zvfkyl	152	8	the	the	DT
cord-292688-w4zvfkyl	152	9	content	content	NN
cord-292688-w4zvfkyl	152	10	,	,	,
cord-292688-w4zvfkyl	152	11	composition	composition	NN
cord-292688-w4zvfkyl	152	12	and	and	CC
cord-292688-w4zvfkyl	152	13	destination	destination	NN
cord-292688-w4zvfkyl	152	14	of	of	IN
cord-292688-w4zvfkyl	152	15	CCV	CCV	NNP
cord-292688-w4zvfkyl	152	16	budding	bud	VBG
cord-292688-w4zvfkyl	152	17	from	from	IN
cord-292688-w4zvfkyl	152	18	the	the	DT
cord-292688-w4zvfkyl	152	19	ISG	ISG	NNP
cord-292688-w4zvfkyl	152	20	,	,	,
cord-292688-w4zvfkyl	152	21	and	and	CC
cord-292688-w4zvfkyl	152	22	indeed	indeed	RB
cord-292688-w4zvfkyl	152	23	the	the	DT
cord-292688-w4zvfkyl	152	24	CCVs	ccv	NNS
cord-292688-w4zvfkyl	152	25	themselves	-PRON-	PRP
cord-292688-w4zvfkyl	152	26	have	have	VBP
cord-292688-w4zvfkyl	152	27	not	not	RB
cord-292688-w4zvfkyl	152	28	been	be	VBN
cord-292688-w4zvfkyl	152	29	identi¢ed	identi¢ed	''
cord-292688-w4zvfkyl	152	30	.	.	.
cord-292688-w4zvfkyl	153	1	A	a	DT
cord-292688-w4zvfkyl	153	2	related	related	JJ
cord-292688-w4zvfkyl	153	3	question	question	NN
cord-292688-w4zvfkyl	153	4	concerns	concern	VBZ
cord-292688-w4zvfkyl	153	5	the	the	DT
cord-292688-w4zvfkyl	153	6	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	153	7	-	-	HYPH
cord-292688-w4zvfkyl	153	8	like	like	JJ
cord-292688-w4zvfkyl	153	9	secretion	secretion	NN
cord-292688-w4zvfkyl	153	10	of	of	IN
cord-292688-w4zvfkyl	153	11	proteins	protein	NNS
cord-292688-w4zvfkyl	153	12	which	which	WDT
cord-292688-w4zvfkyl	153	13	could	could	MD
cord-292688-w4zvfkyl	153	14	be	be	VB
cord-292688-w4zvfkyl	153	15	considered	consider	VBN
cord-292688-w4zvfkyl	153	16	true	true	JJ
cord-292688-w4zvfkyl	153	17	markers	marker	NNS
cord-292688-w4zvfkyl	153	18	of	of	IN
cord-292688-w4zvfkyl	153	19	the	the	DT
cord-292688-w4zvfkyl	153	20	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	153	21	pathway	pathway	NN
cord-292688-w4zvfkyl	153	22	,	,	,
cord-292688-w4zvfkyl	153	23	and	and	CC
cord-292688-w4zvfkyl	153	24	those	those	DT
cord-292688-w4zvfkyl	153	25	which	which	WDT
cord-292688-w4zvfkyl	153	26	are	be	VBP
cord-292688-w4zvfkyl	153	27	unwanted	unwanted	JJ
cord-292688-w4zvfkyl	153	28	products	product	NNS
cord-292688-w4zvfkyl	153	29	from	from	IN
cord-292688-w4zvfkyl	153	30	the	the	DT
cord-292688-w4zvfkyl	153	31	processing	processing	NN
cord-292688-w4zvfkyl	153	32	of	of	IN
cord-292688-w4zvfkyl	153	33	prohormones	prohormone	NNS
cord-292688-w4zvfkyl	153	34	,	,	,
cord-292688-w4zvfkyl	153	35	such	such	JJ
cord-292688-w4zvfkyl	153	36	as	as	IN
cord-292688-w4zvfkyl	153	37	C	c	NN
cord-292688-w4zvfkyl	153	38	-	-	HYPH
cord-292688-w4zvfkyl	153	39	peptide	peptide	NN
cord-292688-w4zvfkyl	153	40	.	.	.
cord-292688-w4zvfkyl	154	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	154	2	has	have	VBZ
cord-292688-w4zvfkyl	154	3	been	be	VBN
cord-292688-w4zvfkyl	154	4	proposed	propose	VBN
cord-292688-w4zvfkyl	154	5	that	that	IN
cord-292688-w4zvfkyl	154	6	CCVs	ccv	NNS
cord-292688-w4zvfkyl	154	7	might	may	MD
cord-292688-w4zvfkyl	154	8	be	be	VB
cord-292688-w4zvfkyl	154	9	a	a	DT
cord-292688-w4zvfkyl	154	10	vesicular	vesicular	JJ
cord-292688-w4zvfkyl	154	11	carrier	carrier	NN
cord-292688-w4zvfkyl	154	12	for	for	IN
cord-292688-w4zvfkyl	154	13	these	these	DT
cord-292688-w4zvfkyl	154	14	population	population	NN
cord-292688-w4zvfkyl	154	15	of	of	IN
cord-292688-w4zvfkyl	154	16	molecules	molecule	NNS
cord-292688-w4zvfkyl	154	17	[	[	-LRB-
cord-292688-w4zvfkyl	154	18	64	64	CD
cord-292688-w4zvfkyl	154	19	]	]	-RRB-
cord-292688-w4zvfkyl	154	20	.	.	.
cord-292688-w4zvfkyl	155	1	This	this	DT
cord-292688-w4zvfkyl	155	2	raises	raise	VBZ
cord-292688-w4zvfkyl	155	3	a	a	DT
cord-292688-w4zvfkyl	155	4	very	very	RB
cord-292688-w4zvfkyl	155	5	intriguing	intriguing	JJ
cord-292688-w4zvfkyl	155	6	set	set	NN
cord-292688-w4zvfkyl	155	7	of	of	IN
cord-292688-w4zvfkyl	155	8	questions	question	NNS
cord-292688-w4zvfkyl	155	9	:	:	:
cord-292688-w4zvfkyl	155	10	are	be	VBP
cord-292688-w4zvfkyl	155	11	there	there	EX
cord-292688-w4zvfkyl	155	12	multiple	multiple	JJ
cord-292688-w4zvfkyl	155	13	classes	class	NNS
cord-292688-w4zvfkyl	155	14	of	of	IN
cord-292688-w4zvfkyl	155	15	CCVs	ccv	NNS
cord-292688-w4zvfkyl	155	16	forming	form	VBG
cord-292688-w4zvfkyl	155	17	from	from	IN
cord-292688-w4zvfkyl	155	18	the	the	DT
cord-292688-w4zvfkyl	155	19	ISG	ISG	NNP
cord-292688-w4zvfkyl	155	20	all	all	RB
cord-292688-w4zvfkyl	155	21	with	with	IN
cord-292688-w4zvfkyl	155	22	a	a	DT
cord-292688-w4zvfkyl	155	23	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	155	24	cargo	cargo	NN
cord-292688-w4zvfkyl	155	25	?	?	.
cord-292688-w4zvfkyl	155	26	,	,	,
cord-292688-w4zvfkyl	155	27	would	would	MD
cord-292688-w4zvfkyl	155	28	these	these	DT
cord-292688-w4zvfkyl	155	29	CCVs	ccv	NNS
cord-292688-w4zvfkyl	155	30	all	all	DT
cord-292688-w4zvfkyl	155	31	have	have	VBP
cord-292688-w4zvfkyl	155	32	a	a	DT
cord-292688-w4zvfkyl	155	33	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	155	34	destination	destination	NN
cord-292688-w4zvfkyl	155	35	?	?	.
cord-292688-w4zvfkyl	156	1	or	or	CC
cord-292688-w4zvfkyl	156	2	is	be	VBZ
cord-292688-w4zvfkyl	156	3	there	there	EX
cord-292688-w4zvfkyl	156	4	a	a	DT
cord-292688-w4zvfkyl	156	5	single	single	JJ
cord-292688-w4zvfkyl	156	6	species	specie	NNS
cord-292688-w4zvfkyl	156	7	of	of	IN
cord-292688-w4zvfkyl	156	8	CCVs	ccv	NNS
cord-292688-w4zvfkyl	156	9	forming	form	VBG
cord-292688-w4zvfkyl	156	10	with	with	IN
cord-292688-w4zvfkyl	156	11	a	a	DT
cord-292688-w4zvfkyl	156	12	mixed	mixed	JJ
cord-292688-w4zvfkyl	156	13	cargo	cargo	NN
cord-292688-w4zvfkyl	156	14	?	?	.
cord-292688-w4zvfkyl	157	1	would	would	MD
cord-292688-w4zvfkyl	157	2	this	this	DT
cord-292688-w4zvfkyl	157	3	CCV	CCV	NNP
cord-292688-w4zvfkyl	157	4	deliver	deliver	VB
cord-292688-w4zvfkyl	157	5	its	-PRON-	PRP$
cord-292688-w4zvfkyl	157	6	cargo	cargo	NN
cord-292688-w4zvfkyl	157	7	to	to	IN
cord-292688-w4zvfkyl	157	8	one	one	CD
cord-292688-w4zvfkyl	157	9	destination	destination	NN
cord-292688-w4zvfkyl	157	10	,	,	,
cord-292688-w4zvfkyl	157	11	for	for	IN
cord-292688-w4zvfkyl	157	12	example	example	NN
cord-292688-w4zvfkyl	157	13	,	,	,
cord-292688-w4zvfkyl	157	14	the	the	DT
cord-292688-w4zvfkyl	157	15	endosome	endosome	NN
cord-292688-w4zvfkyl	157	16	,	,	,
cord-292688-w4zvfkyl	157	17	from	from	IN
cord-292688-w4zvfkyl	157	18	where	where	WRB
cord-292688-w4zvfkyl	157	19	further	further	JJ
cord-292688-w4zvfkyl	157	20	sorting	sorting	NN
cord-292688-w4zvfkyl	157	21	would	would	MD
cord-292688-w4zvfkyl	157	22	occur	occur	VB
cord-292688-w4zvfkyl	157	23	?	?	.
cord-292688-w4zvfkyl	158	1	While	while	IN
cord-292688-w4zvfkyl	158	2	the	the	DT
cord-292688-w4zvfkyl	158	3	mechanism	mechanism	NN
cord-292688-w4zvfkyl	158	4	for	for	IN
cord-292688-w4zvfkyl	158	5	selection	selection	NN
cord-292688-w4zvfkyl	158	6	and	and	CC
cord-292688-w4zvfkyl	158	7	transport	transport	NN
cord-292688-w4zvfkyl	158	8	via	via	IN
cord-292688-w4zvfkyl	158	9	CCVs	ccv	NNS
cord-292688-w4zvfkyl	158	10	is	be	VBZ
cord-292688-w4zvfkyl	158	11	clear	clear	JJ
cord-292688-w4zvfkyl	158	12	when	when	WRB
cord-292688-w4zvfkyl	158	13	one	one	PRP
cord-292688-w4zvfkyl	158	14	assumes	assume	VBZ
cord-292688-w4zvfkyl	158	15	the	the	DT
cord-292688-w4zvfkyl	158	16	cargo	cargo	NN
cord-292688-w4zvfkyl	158	17	associates	associate	NNS
cord-292688-w4zvfkyl	158	18	with	with	IN
cord-292688-w4zvfkyl	158	19	a	a	DT
cord-292688-w4zvfkyl	158	20	transmembrane	transmembrane	NN
cord-292688-w4zvfkyl	158	21	receptor	receptor	NN
cord-292688-w4zvfkyl	158	22	,	,	,
cord-292688-w4zvfkyl	158	23	it	-PRON-	PRP
cord-292688-w4zvfkyl	158	24	is	be	VBZ
cord-292688-w4zvfkyl	158	25	more	more	RBR
cord-292688-w4zvfkyl	158	26	complex	complex	JJ
cord-292688-w4zvfkyl	158	27	for	for	IN
cord-292688-w4zvfkyl	158	28	other	other	JJ
cord-292688-w4zvfkyl	158	29	cargo	cargo	NN
cord-292688-w4zvfkyl	158	30	proteins	protein	NNS
cord-292688-w4zvfkyl	158	31	such	such	JJ
cord-292688-w4zvfkyl	158	32	as	as	IN
cord-292688-w4zvfkyl	158	33	the	the	DT
cord-292688-w4zvfkyl	158	34	C	C	NNP
cord-292688-w4zvfkyl	158	35	-	-	HYPH
cord-292688-w4zvfkyl	158	36	peptide	peptide	NN
cord-292688-w4zvfkyl	158	37	,	,	,
cord-292688-w4zvfkyl	158	38	or	or	CC
cord-292688-w4zvfkyl	158	39	those	those	DT
cord-292688-w4zvfkyl	158	40	proteins	protein	NNS
cord-292688-w4zvfkyl	158	41	which	which	WDT
cord-292688-w4zvfkyl	158	42	follow	follow	VBP
cord-292688-w4zvfkyl	158	43	a	a	DT
cord-292688-w4zvfkyl	158	44	bulk-£ow	bulk-£ow	``
cord-292688-w4zvfkyl	158	45	pathway	pathway	NN
cord-292688-w4zvfkyl	158	46	[	[	-LRB-
cord-292688-w4zvfkyl	158	47	65	65	CD
cord-292688-w4zvfkyl	158	48	]	]	-RRB-
cord-292688-w4zvfkyl	158	49	which	which	WDT
cord-292688-w4zvfkyl	158	50	has	have	VBZ
cord-292688-w4zvfkyl	158	51	not	not	RB
cord-292688-w4zvfkyl	158	52	been	be	VBN
cord-292688-w4zvfkyl	158	53	thought	think	VBN
cord-292688-w4zvfkyl	158	54	to	to	TO
cord-292688-w4zvfkyl	158	55	be	be	VB
cord-292688-w4zvfkyl	158	56	signal	signal	NN
cord-292688-w4zvfkyl	158	57	-	-	HYPH
cord-292688-w4zvfkyl	158	58	mediated	mediate	VBN
cord-292688-w4zvfkyl	158	59	.	.	.
cord-292688-w4zvfkyl	159	1	How	how	WRB
cord-292688-w4zvfkyl	159	2	does	do	VBZ
cord-292688-w4zvfkyl	159	3	this	this	DT
cord-292688-w4zvfkyl	159	4	signal	signal	NN
cord-292688-w4zvfkyl	159	5	-	-	HYPH
cord-292688-w4zvfkyl	159	6	less	less	JJR
cord-292688-w4zvfkyl	159	7	type	type	NN
cord-292688-w4zvfkyl	159	8	of	of	IN
cord-292688-w4zvfkyl	159	9	cargo	cargo	NN
cord-292688-w4zvfkyl	159	10	enter	enter	VBP
cord-292688-w4zvfkyl	159	11	the	the	DT
cord-292688-w4zvfkyl	159	12	CCVs	ccv	NNS
cord-292688-w4zvfkyl	159	13	allowing	allow	VBG
cord-292688-w4zvfkyl	159	14	it	-PRON-	PRP
cord-292688-w4zvfkyl	159	15	to	to	TO
cord-292688-w4zvfkyl	159	16	be	be	VB
cord-292688-w4zvfkyl	159	17	removed	remove	VBN
cord-292688-w4zvfkyl	159	18	?	?	.
cord-292688-w4zvfkyl	160	1	If	if	IN
cord-292688-w4zvfkyl	160	2	it	-PRON-	PRP
cord-292688-w4zvfkyl	160	3	is	be	VBZ
cord-292688-w4zvfkyl	160	4	simply	simply	RB
cord-292688-w4zvfkyl	160	5	a	a	DT
cord-292688-w4zvfkyl	160	6	case	case	NN
cord-292688-w4zvfkyl	160	7	of	of	IN
cord-292688-w4zvfkyl	160	8	exclusion	exclusion	NN
cord-292688-w4zvfkyl	160	9	,	,	,
cord-292688-w4zvfkyl	160	10	as	as	IN
cord-292688-w4zvfkyl	160	11	formulated	formulate	VBN
cord-292688-w4zvfkyl	160	12	by	by	IN
cord-292688-w4zvfkyl	160	13	Arvan	Arvan	NNP
cord-292688-w4zvfkyl	160	14	et	et	NNP
cord-292688-w4zvfkyl	160	15	al	al	NNP
cord-292688-w4zvfkyl	160	16	.	.	.
cord-292688-w4zvfkyl	161	1	in	in	IN
cord-292688-w4zvfkyl	161	2	their`sorting	their`sorting	NNP
cord-292688-w4zvfkyl	161	3	by	by	IN
cord-292688-w4zvfkyl	161	4	retention	retention	NN
cord-292688-w4zvfkyl	161	5	'	'	''
cord-292688-w4zvfkyl	161	6	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	161	7	,	,	,
cord-292688-w4zvfkyl	161	8	one	one	PRP
cord-292688-w4zvfkyl	161	9	would	would	MD
cord-292688-w4zvfkyl	161	10	predict	predict	VB
cord-292688-w4zvfkyl	161	11	it	-PRON-	PRP
cord-292688-w4zvfkyl	161	12	could	could	MD
cord-292688-w4zvfkyl	161	13	not	not	RB
cord-292688-w4zvfkyl	161	14	be	be	VB
cord-292688-w4zvfkyl	161	15	100	100	CD
cord-292688-w4zvfkyl	161	16	%	%	NN
cord-292688-w4zvfkyl	161	17	e¤cient	e¤cient	NNP
cord-292688-w4zvfkyl	161	18	and	and	CC
cord-292688-w4zvfkyl	161	19	some	some	DT
cord-292688-w4zvfkyl	161	20	C	c	NN
cord-292688-w4zvfkyl	161	21	-	-	HYPH
cord-292688-w4zvfkyl	161	22	peptide	peptide	NN
cord-292688-w4zvfkyl	161	23	would	would	MD
cord-292688-w4zvfkyl	161	24	be	be	VB
cord-292688-w4zvfkyl	161	25	found	find	VBN
cord-292688-w4zvfkyl	161	26	in	in	IN
cord-292688-w4zvfkyl	161	27	the	the	DT
cord-292688-w4zvfkyl	161	28	medium	medium	NN
cord-292688-w4zvfkyl	161	29	after	after	IN
cord-292688-w4zvfkyl	161	30	stimulation	stimulation	NN
cord-292688-w4zvfkyl	161	31	of	of	IN
cord-292688-w4zvfkyl	161	32	MSG	MSG	NNP
cord-292688-w4zvfkyl	161	33	.	.	.
cord-292688-w4zvfkyl	162	1	This	this	DT
cord-292688-w4zvfkyl	162	2	has	have	VBZ
cord-292688-w4zvfkyl	162	3	been	be	VBN
cord-292688-w4zvfkyl	162	4	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	162	5	for	for	IN
cord-292688-w4zvfkyl	162	6	C	c	NN
cord-292688-w4zvfkyl	162	7	-	-	HYPH
cord-292688-w4zvfkyl	162	8	peptide	peptide	NN
cord-292688-w4zvfkyl	162	9	(	(	-LRB-
cord-292688-w4zvfkyl	162	10	see	see	VB
cord-292688-w4zvfkyl	162	11	[	[	-LRB-
cord-292688-w4zvfkyl	162	12	64	64	CD
cord-292688-w4zvfkyl	162	13	]	]	-RRB-
cord-292688-w4zvfkyl	162	14	and	and	CC
cord-292688-w4zvfkyl	162	15	the	the	DT
cord-292688-w4zvfkyl	162	16	references	reference	NNS
cord-292688-w4zvfkyl	162	17	therein	therein	RB
cord-292688-w4zvfkyl	162	18	)	)	-RRB-
cord-292688-w4zvfkyl	162	19	.	.	.
cord-292688-w4zvfkyl	163	1	Alternatively	alternatively	RB
cord-292688-w4zvfkyl	163	2	,	,	,
cord-292688-w4zvfkyl	163	3	it	-PRON-	PRP
cord-292688-w4zvfkyl	163	4	may	may	MD
cord-292688-w4zvfkyl	163	5	be	be	VB
cord-292688-w4zvfkyl	163	6	that	that	IN
cord-292688-w4zvfkyl	163	7	multiple	multiple	JJ
cord-292688-w4zvfkyl	163	8	vesicular	vesicular	JJ
cord-292688-w4zvfkyl	163	9	carriers	carrier	NNS
cord-292688-w4zvfkyl	163	10	bud	bud	NN
cord-292688-w4zvfkyl	163	11	from	from	IN
cord-292688-w4zvfkyl	163	12	the	the	DT
cord-292688-w4zvfkyl	163	13	ISG	ISG	NNP
cord-292688-w4zvfkyl	163	14	with	with	IN
cord-292688-w4zvfkyl	163	15	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	163	16	cargo	cargo	NN
cord-292688-w4zvfkyl	163	17	.	.	.
cord-292688-w4zvfkyl	164	1	Depending	depend	VBG
cord-292688-w4zvfkyl	164	2	on	on	IN
cord-292688-w4zvfkyl	164	3	the	the	DT
cord-292688-w4zvfkyl	164	4	cargo	cargo	NN
cord-292688-w4zvfkyl	164	5	,	,	,
cord-292688-w4zvfkyl	164	6	distinct	distinct	JJ
cord-292688-w4zvfkyl	164	7	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	164	8	could	could	MD
cord-292688-w4zvfkyl	164	9	be	be	VB
cord-292688-w4zvfkyl	164	10	used	use	VBN
cord-292688-w4zvfkyl	164	11	for	for	IN
cord-292688-w4zvfkyl	164	12	selection	selection	NN
cord-292688-w4zvfkyl	164	13	to	to	TO
cord-292688-w4zvfkyl	164	14	increase	increase	VB
cord-292688-w4zvfkyl	164	15	the	the	DT
cord-292688-w4zvfkyl	164	16	e¤ciency	e¤ciency	NN
cord-292688-w4zvfkyl	164	17	of	of	IN
cord-292688-w4zvfkyl	164	18	removal	removal	NN
cord-292688-w4zvfkyl	164	19	of	of	IN
cord-292688-w4zvfkyl	164	20	nonsecretory	nonsecretory	JJ
cord-292688-w4zvfkyl	164	21	granule	granule	NN
cord-292688-w4zvfkyl	164	22	proteins	protein	NNS
cord-292688-w4zvfkyl	164	23	from	from	IN
cord-292688-w4zvfkyl	164	24	the	the	DT
cord-292688-w4zvfkyl	164	25	maturing	mature	VBG
cord-292688-w4zvfkyl	164	26	ISGs	isg	NNS
cord-292688-w4zvfkyl	164	27	.	.	.
cord-292688-w4zvfkyl	165	1	While	while	IN
cord-292688-w4zvfkyl	165	2	the	the	DT
cord-292688-w4zvfkyl	165	3	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	165	4	involved	involve	VBN
cord-292688-w4zvfkyl	165	5	in	in	IN
cord-292688-w4zvfkyl	165	6	the	the	DT
cord-292688-w4zvfkyl	165	7	formation	formation	NN
cord-292688-w4zvfkyl	165	8	of	of	IN
cord-292688-w4zvfkyl	165	9	both	both	CC
cord-292688-w4zvfkyl	165	10	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	165	11	and	and	CC
cord-292688-w4zvfkyl	165	12	regulated	regulated	JJ
cord-292688-w4zvfkyl	165	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	165	14	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	165	15	from	from	IN
cord-292688-w4zvfkyl	165	16	the	the	DT
cord-292688-w4zvfkyl	165	17	TGN	TGN	NNP
cord-292688-w4zvfkyl	165	18	is	be	VBZ
cord-292688-w4zvfkyl	165	19	largely	largely	RB
cord-292688-w4zvfkyl	165	20	unknown	unknown	JJ
cord-292688-w4zvfkyl	165	21	there	there	EX
cord-292688-w4zvfkyl	165	22	have	have	VBP
cord-292688-w4zvfkyl	165	23	been	be	VBN
cord-292688-w4zvfkyl	165	24	recent	recent	JJ
cord-292688-w4zvfkyl	165	25	reports	report	NNS
cord-292688-w4zvfkyl	165	26	which	which	WDT
cord-292688-w4zvfkyl	165	27	suggest	suggest	VBP
cord-292688-w4zvfkyl	165	28	that	that	IN
cord-292688-w4zvfkyl	165	29	both	both	PDT
cord-292688-w4zvfkyl	165	30	these	these	DT
cord-292688-w4zvfkyl	165	31	budding	budding	JJ
cord-292688-w4zvfkyl	165	32	reactions	reaction	NNS
cord-292688-w4zvfkyl	165	33	maybe	maybe	RB
cord-292688-w4zvfkyl	165	34	unique	unique	JJ
cord-292688-w4zvfkyl	165	35	in	in	IN
cord-292688-w4zvfkyl	165	36	that	that	IN
cord-292688-w4zvfkyl	165	37	they	-PRON-	PRP
cord-292688-w4zvfkyl	165	38	function	function	VBP
cord-292688-w4zvfkyl	165	39	independently	independently	RB
cord-292688-w4zvfkyl	165	40	of	of	IN
cord-292688-w4zvfkyl	165	41	known	know	VBN
cord-292688-w4zvfkyl	165	42	coat	coat	NN
cord-292688-w4zvfkyl	165	43	proteins	protein	NNS
cord-292688-w4zvfkyl	165	44	.	.	.
cord-292688-w4zvfkyl	166	1	Morphological	morphological	JJ
cord-292688-w4zvfkyl	166	2	data	datum	NNS
cord-292688-w4zvfkyl	166	3	based	base	VBN
cord-292688-w4zvfkyl	166	4	on	on	IN
cord-292688-w4zvfkyl	166	5	high	high	JJ
cord-292688-w4zvfkyl	166	6	voltage	voltage	NN
cord-292688-w4zvfkyl	166	7	electron	electron	NN
cord-292688-w4zvfkyl	166	8	microscopy	microscopy	NN
cord-292688-w4zvfkyl	166	9	suggests	suggest	VBZ
cord-292688-w4zvfkyl	166	10	that	that	IN
cord-292688-w4zvfkyl	166	11	the	the	DT
cord-292688-w4zvfkyl	166	12	formation	formation	NN
cord-292688-w4zvfkyl	166	13	of	of	IN
cord-292688-w4zvfkyl	166	14	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	166	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	166	16	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	166	17	from	from	IN
cord-292688-w4zvfkyl	166	18	the	the	DT
cord-292688-w4zvfkyl	166	19	TGN	TGN	NNP
cord-292688-w4zvfkyl	166	20	involves	involve	VBZ
cord-292688-w4zvfkyl	166	21	a`lace	a`lace	NN
cord-292688-w4zvfkyl	166	22	-	-	HYPH
cord-292688-w4zvfkyl	166	23	like	like	JJ
cord-292688-w4zvfkyl	166	24	'	'	''
cord-292688-w4zvfkyl	166	25	coat	coat	NN
cord-292688-w4zvfkyl	166	26	[	[	-LRB-
cord-292688-w4zvfkyl	166	27	66	66	CD
cord-292688-w4zvfkyl	166	28	]	]	-RRB-
cord-292688-w4zvfkyl	166	29	.	.	.
cord-292688-w4zvfkyl	167	1	The	the	DT
cord-292688-w4zvfkyl	167	2	components	component	NNS
cord-292688-w4zvfkyl	167	3	of	of	IN
cord-292688-w4zvfkyl	167	4	this	this	DT
cord-292688-w4zvfkyl	167	5	coat	coat	NN
cord-292688-w4zvfkyl	167	6	have	have	VBP
cord-292688-w4zvfkyl	167	7	yet	yet	RB
cord-292688-w4zvfkyl	167	8	to	to	TO
cord-292688-w4zvfkyl	167	9	be	be	VB
cord-292688-w4zvfkyl	167	10	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	168	1	but	but	CC
cord-292688-w4zvfkyl	168	2	may	may	MD
cord-292688-w4zvfkyl	168	3	be	be	VB
cord-292688-w4zvfkyl	168	4	associated	associate	VBN
cord-292688-w4zvfkyl	168	5	with	with	IN
cord-292688-w4zvfkyl	168	6	the	the	DT
cord-292688-w4zvfkyl	168	7	p62	p62	NN
cord-292688-w4zvfkyl	168	8	complex	complex	NN
cord-292688-w4zvfkyl	169	1	identi¢ed	identi¢ed	NNP
cord-292688-w4zvfkyl	169	2	by	by	IN
cord-292688-w4zvfkyl	169	3	Howell	Howell	NNP
cord-292688-w4zvfkyl	169	4	and	and	CC
cord-292688-w4zvfkyl	169	5	colleagues	colleague	NNS
cord-292688-w4zvfkyl	169	6	[	[	-LRB-
cord-292688-w4zvfkyl	169	7	67	67	CD
cord-292688-w4zvfkyl	169	8	]	]	-RRB-
cord-292688-w4zvfkyl	170	1	and	and	CC
cord-292688-w4zvfkyl	170	2	include	include	VBP
cord-292688-w4zvfkyl	170	3	p200	p200	NNP
cord-292688-w4zvfkyl	170	4	[	[	-LRB-
cord-292688-w4zvfkyl	170	5	68	68	CD
cord-292688-w4zvfkyl	170	6	]	]	-RRB-
cord-292688-w4zvfkyl	170	7	.	.	.
cord-292688-w4zvfkyl	171	1	Conventional	conventional	JJ
cord-292688-w4zvfkyl	171	2	electron	electron	NN
cord-292688-w4zvfkyl	171	3	microscopy	microscopy	NN
cord-292688-w4zvfkyl	171	4	and	and	CC
cord-292688-w4zvfkyl	171	5	immunogold	immunogold	JJ
cord-292688-w4zvfkyl	171	6	labelling	labelling	NN
cord-292688-w4zvfkyl	171	7	has	have	VBZ
cord-292688-w4zvfkyl	171	8	revealed	reveal	VBN
cord-292688-w4zvfkyl	171	9	that	that	IN
cord-292688-w4zvfkyl	171	10	patches	patch	NNS
cord-292688-w4zvfkyl	171	11	of	of	IN
cord-292688-w4zvfkyl	171	12	clathrin	clathrin	NN
cord-292688-w4zvfkyl	171	13	are	be	VBP
cord-292688-w4zvfkyl	171	14	present	present	JJ
cord-292688-w4zvfkyl	171	15	on	on	IN
cord-292688-w4zvfkyl	171	16	the	the	DT
cord-292688-w4zvfkyl	171	17	TGN	TGN	NNP
cord-292688-w4zvfkyl	171	18	in	in	IN
cord-292688-w4zvfkyl	171	19	the	the	DT
cord-292688-w4zvfkyl	171	20	vicinity	vicinity	NN
cord-292688-w4zvfkyl	171	21	of	of	IN
cord-292688-w4zvfkyl	171	22	forming	form	VBG
cord-292688-w4zvfkyl	171	23	ISGs	isg	NNS
cord-292688-w4zvfkyl	171	24	and	and	CC
cord-292688-w4zvfkyl	171	25	are	be	VBP
cord-292688-w4zvfkyl	171	26	also	also	RB
cord-292688-w4zvfkyl	171	27	found	find	VBN
cord-292688-w4zvfkyl	171	28	on	on	IN
cord-292688-w4zvfkyl	171	29	ISGs	isg	NNS
cord-292688-w4zvfkyl	171	30	[	[	-LRB-
cord-292688-w4zvfkyl	171	31	10	10	CD
cord-292688-w4zvfkyl	171	32	,	,	,
cord-292688-w4zvfkyl	171	33	69	69	CD
cord-292688-w4zvfkyl	171	34	]	]	-RRB-
cord-292688-w4zvfkyl	171	35	.	.	.
cord-292688-w4zvfkyl	172	1	However	however	RB
cord-292688-w4zvfkyl	172	2	,	,	,
cord-292688-w4zvfkyl	172	3	there	there	EX
cord-292688-w4zvfkyl	172	4	is	be	VBZ
cord-292688-w4zvfkyl	172	5	no	no	DT
cord-292688-w4zvfkyl	172	6	biochemical	biochemical	JJ
cord-292688-w4zvfkyl	172	7	data	datum	NNS
cord-292688-w4zvfkyl	172	8	available	available	JJ
cord-292688-w4zvfkyl	172	9	to	to	IN
cord-292688-w4zvfkyl	172	10	date	date	NN
cord-292688-w4zvfkyl	172	11	which	which	WDT
cord-292688-w4zvfkyl	172	12	supports	support	VBZ
cord-292688-w4zvfkyl	172	13	the	the	DT
cord-292688-w4zvfkyl	172	14	role	role	NN
cord-292688-w4zvfkyl	172	15	of	of	IN
cord-292688-w4zvfkyl	172	16	clathrin	clathrin	NN
cord-292688-w4zvfkyl	172	17	in	in	IN
cord-292688-w4zvfkyl	172	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	172	19	granule	granule	NN
cord-292688-w4zvfkyl	172	20	formation	formation	NN
cord-292688-w4zvfkyl	172	21	.	.	.
cord-292688-w4zvfkyl	173	1	Recent	recent	JJ
cord-292688-w4zvfkyl	173	2	results	result	NNS
cord-292688-w4zvfkyl	173	3	concerning	concern	VBG
cord-292688-w4zvfkyl	173	4	the	the	DT
cord-292688-w4zvfkyl	173	5	formation	formation	NN
cord-292688-w4zvfkyl	173	6	of	of	IN
cord-292688-w4zvfkyl	173	7	secretory	secretory	JJ
cord-292688-w4zvfkyl	173	8	granules	granule	NNS
cord-292688-w4zvfkyl	173	9	have	have	VBP
cord-292688-w4zvfkyl	173	10	been	be	VBN
cord-292688-w4zvfkyl	173	11	obtained	obtain	VBN
cord-292688-w4zvfkyl	173	12	primarily	primarily	RB
cord-292688-w4zvfkyl	173	13	from	from	IN
cord-292688-w4zvfkyl	173	14	two	two	CD
cord-292688-w4zvfkyl	173	15	in	in	FW
cord-292688-w4zvfkyl	173	16	vitro	vitro	FW
cord-292688-w4zvfkyl	173	17	systems	system	NNS
cord-292688-w4zvfkyl	173	18	which	which	WDT
cord-292688-w4zvfkyl	173	19	reconstitute	reconstitute	VBP
cord-292688-w4zvfkyl	173	20	budding	bud	VBG
cord-292688-w4zvfkyl	173	21	from	from	IN
cord-292688-w4zvfkyl	173	22	TGN	TGN	NNP
cord-292688-w4zvfkyl	173	23	membranes	membrane	NNS
cord-292688-w4zvfkyl	173	24	;	;	:
cord-292688-w4zvfkyl	173	25	one	one	CD
cord-292688-w4zvfkyl	173	26	using	use	VBG
cord-292688-w4zvfkyl	173	27	a	a	DT
cord-292688-w4zvfkyl	173	28	post	post	JJ
cord-292688-w4zvfkyl	173	29	-	-	JJ
cord-292688-w4zvfkyl	173	30	nuclear	nuclear	JJ
cord-292688-w4zvfkyl	173	31	supernatant	supernatant	NN
cord-292688-w4zvfkyl	173	32	derived	derive	VBN
cord-292688-w4zvfkyl	173	33	from	from	IN
cord-292688-w4zvfkyl	173	34	PC12	pc12	JJ
cord-292688-w4zvfkyl	173	35	cells	cell	NNS
cord-292688-w4zvfkyl	173	36	[	[	-LRB-
cord-292688-w4zvfkyl	173	37	70	70	CD
cord-292688-w4zvfkyl	173	38	]	]	-RRB-
cord-292688-w4zvfkyl	173	39	and	and	CC
cord-292688-w4zvfkyl	173	40	the	the	DT
cord-292688-w4zvfkyl	173	41	second	second	JJ
cord-292688-w4zvfkyl	173	42	semi	semi	JJ
cord-292688-w4zvfkyl	173	43	-	-	JJ
cord-292688-w4zvfkyl	173	44	intact	intact	JJ
cord-292688-w4zvfkyl	173	45	GH	gh	NN
cord-292688-w4zvfkyl	173	46	4	4	CD
cord-292688-w4zvfkyl	173	47	C	c	NN
cord-292688-w4zvfkyl	173	48	1	1	CD
cord-292688-w4zvfkyl	173	49	cells	cell	NNS
cord-292688-w4zvfkyl	173	50	[	[	-LRB-
cord-292688-w4zvfkyl	173	51	18	18	CD
cord-292688-w4zvfkyl	173	52	]	]	-RRB-
cord-292688-w4zvfkyl	173	53	.	.	.
cord-292688-w4zvfkyl	174	1	While	while	IN
cord-292688-w4zvfkyl	174	2	in	in	IN
cord-292688-w4zvfkyl	174	3	the	the	DT
cord-292688-w4zvfkyl	174	4	former	former	JJ
cord-292688-w4zvfkyl	174	5	assay	assay	NN
cord-292688-w4zvfkyl	174	6	it	-PRON-	PRP
cord-292688-w4zvfkyl	174	7	is	be	VBZ
cord-292688-w4zvfkyl	174	8	possible	possible	JJ
cord-292688-w4zvfkyl	174	9	to	to	TO
cord-292688-w4zvfkyl	174	10	identify	identify	VB
cord-292688-w4zvfkyl	174	11	two	two	CD
cord-292688-w4zvfkyl	174	12	classes	class	NNS
cord-292688-w4zvfkyl	174	13	of	of	IN
cord-292688-w4zvfkyl	174	14	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	174	15	budding	bud	VBG
cord-292688-w4zvfkyl	174	16	from	from	IN
cord-292688-w4zvfkyl	174	17	the	the	DT
cord-292688-w4zvfkyl	174	18	TGN	TGN	NNP
cord-292688-w4zvfkyl	174	19	,	,	,
cord-292688-w4zvfkyl	174	20	in	in	IN
cord-292688-w4zvfkyl	174	21	the	the	DT
cord-292688-w4zvfkyl	174	22	latter	latter	JJ
cord-292688-w4zvfkyl	174	23	this	this	DT
cord-292688-w4zvfkyl	174	24	has	have	VBZ
cord-292688-w4zvfkyl	174	25	not	not	RB
cord-292688-w4zvfkyl	174	26	been	be	VBN
cord-292688-w4zvfkyl	174	27	possible	possible	JJ
cord-292688-w4zvfkyl	174	28	.	.	.
cord-292688-w4zvfkyl	175	1	However	however	RB
cord-292688-w4zvfkyl	175	2	,	,	,
cord-292688-w4zvfkyl	175	3	because	because	IN
cord-292688-w4zvfkyl	175	4	there	there	EX
cord-292688-w4zvfkyl	175	5	is	be	VBZ
cord-292688-w4zvfkyl	175	6	no	no	DT
cord-292688-w4zvfkyl	175	7	data	data	NN
cord-292688-w4zvfkyl	175	8	which	which	WDT
cord-292688-w4zvfkyl	175	9	so	so	RB
cord-292688-w4zvfkyl	175	10	far	far	RB
cord-292688-w4zvfkyl	175	11	suggests	suggest	VBZ
cord-292688-w4zvfkyl	175	12	the	the	DT
cord-292688-w4zvfkyl	175	13	requirements	requirement	NNS
cord-292688-w4zvfkyl	175	14	for	for	IN
cord-292688-w4zvfkyl	175	15	formation	formation	NN
cord-292688-w4zvfkyl	175	16	of	of	IN
cord-292688-w4zvfkyl	175	17	an	an	DT
cord-292688-w4zvfkyl	175	18	ISG	ISG	NNP
cord-292688-w4zvfkyl	175	19	are	be	VBP
cord-292688-w4zvfkyl	175	20	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	175	21	from	from	IN
cord-292688-w4zvfkyl	175	22	that	that	DT
cord-292688-w4zvfkyl	175	23	for	for	IN
cord-292688-w4zvfkyl	175	24	a	a	DT
cord-292688-w4zvfkyl	175	25	CSV	csv	NN
cord-292688-w4zvfkyl	175	26	,	,	,
cord-292688-w4zvfkyl	175	27	they	-PRON-	PRP
cord-292688-w4zvfkyl	175	28	will	will	MD
cord-292688-w4zvfkyl	175	29	be	be	VB
cord-292688-w4zvfkyl	175	30	considered	consider	VBN
cord-292688-w4zvfkyl	175	31	as	as	IN
cord-292688-w4zvfkyl	175	32	congruent	congruent	JJ
cord-292688-w4zvfkyl	175	33	assays	assay	NNS
cord-292688-w4zvfkyl	175	34	and	and	CC
cord-292688-w4zvfkyl	175	35	the	the	DT
cord-292688-w4zvfkyl	175	36	data	datum	NNS
cord-292688-w4zvfkyl	175	37	ob	ob	NNP
cord-292688-w4zvfkyl	175	38	-	-	HYPH
cord-292688-w4zvfkyl	175	39	tained	taine	VBN
cord-292688-w4zvfkyl	175	40	from	from	IN
cord-292688-w4zvfkyl	175	41	both	both	DT
cord-292688-w4zvfkyl	175	42	,	,	,
cord-292688-w4zvfkyl	175	43	and	and	CC
cord-292688-w4zvfkyl	175	44	other	other	JJ
cord-292688-w4zvfkyl	175	45	assays	assay	NNS
cord-292688-w4zvfkyl	175	46	monitoring	monitor	VBG
cord-292688-w4zvfkyl	175	47	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	175	48	secretory	secretory	JJ
cord-292688-w4zvfkyl	175	49	vesicle	vesicle	NN
cord-292688-w4zvfkyl	175	50	formation	formation	NN
cord-292688-w4zvfkyl	175	51	will	will	MD
cord-292688-w4zvfkyl	175	52	be	be	VB
cord-292688-w4zvfkyl	175	53	compared	compare	VBN
cord-292688-w4zvfkyl	175	54	.	.	.
cord-292688-w4zvfkyl	176	1	The	the	DT
cord-292688-w4zvfkyl	176	2	¢rst	¢rst	CD
cord-292688-w4zvfkyl	176	3	observations	observation	NNS
cord-292688-w4zvfkyl	176	4	made	make	VBN
cord-292688-w4zvfkyl	176	5	using	use	VBG
cord-292688-w4zvfkyl	176	6	the	the	DT
cord-292688-w4zvfkyl	176	7	in	in	FW
cord-292688-w4zvfkyl	176	8	vitro	vitro	FW
cord-292688-w4zvfkyl	176	9	budding	bud	VBG
cord-292688-w4zvfkyl	176	10	assays	assay	NNS
cord-292688-w4zvfkyl	176	11	described	describe	VBN
cord-292688-w4zvfkyl	176	12	above	above	RB
cord-292688-w4zvfkyl	176	13	,	,	,
cord-292688-w4zvfkyl	176	14	both	both	DT
cord-292688-w4zvfkyl	176	15	of	of	IN
cord-292688-w4zvfkyl	176	16	which	which	WDT
cord-292688-w4zvfkyl	176	17	are	be	VBP
cord-292688-w4zvfkyl	176	18	ATP	ATP	NNP
cord-292688-w4zvfkyl	176	19	and	and	CC
cord-292688-w4zvfkyl	176	20	cytosol	cytosol	NN
cord-292688-w4zvfkyl	176	21	dependent	dependent	JJ
cord-292688-w4zvfkyl	176	22	,	,	,
cord-292688-w4zvfkyl	176	23	concerned	concern	VBD
cord-292688-w4zvfkyl	176	24	the	the	DT
cord-292688-w4zvfkyl	176	25	requirement	requirement	NN
cord-292688-w4zvfkyl	176	26	for	for	IN
cord-292688-w4zvfkyl	176	27	GTP	GTP	NNP
cord-292688-w4zvfkyl	176	28	.	.	.
cord-292688-w4zvfkyl	177	1	The	the	DT
cord-292688-w4zvfkyl	177	2	formation	formation	NN
cord-292688-w4zvfkyl	177	3	of	of	IN
cord-292688-w4zvfkyl	177	4	secretory	secretory	JJ
cord-292688-w4zvfkyl	177	5	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	177	6	from	from	IN
cord-292688-w4zvfkyl	177	7	the	the	DT
cord-292688-w4zvfkyl	177	8	TGN	TGN	NNP
cord-292688-w4zvfkyl	177	9	requires	require	VBZ
cord-292688-w4zvfkyl	177	10	GTP	gtp	NN
cord-292688-w4zvfkyl	177	11	and	and	CC
cord-292688-w4zvfkyl	177	12	is	be	VBZ
cord-292688-w4zvfkyl	177	13	inhibited	inhibit	VBN
cord-292688-w4zvfkyl	177	14	by	by	IN
cord-292688-w4zvfkyl	177	15	non	non	JJ
cord-292688-w4zvfkyl	177	16	-	-	JJ
cord-292688-w4zvfkyl	177	17	hydrolysable	hydrolysable	JJ
cord-292688-w4zvfkyl	177	18	GTP	GTP	NNP
cord-292688-w4zvfkyl	177	19	analogs	analog	NNS
cord-292688-w4zvfkyl	177	20	[	[	-LRB-
cord-292688-w4zvfkyl	177	21	18	18	CD
cord-292688-w4zvfkyl	177	22	,	,	,
cord-292688-w4zvfkyl	177	23	47	47	CD
cord-292688-w4zvfkyl	177	24	]	]	-RRB-
cord-292688-w4zvfkyl	177	25	.	.	.
cord-292688-w4zvfkyl	178	1	In	in	IN
cord-292688-w4zvfkyl	178	2	the	the	DT
cord-292688-w4zvfkyl	178	3	PC12	pc12	JJ
cord-292688-w4zvfkyl	178	4	cell	cell	NN
cord-292688-w4zvfkyl	178	5	assay	assay	NN
cord-292688-w4zvfkyl	178	6	,	,	,
cord-292688-w4zvfkyl	178	7	the	the	DT
cord-292688-w4zvfkyl	178	8	same	same	JJ
cord-292688-w4zvfkyl	178	9	e¡ect	e¡ect	:
cord-292688-w4zvfkyl	178	10	was	be	VBD
cord-292688-w4zvfkyl	178	11	observed	observe	VBN
cord-292688-w4zvfkyl	178	12	with	with	IN
cord-292688-w4zvfkyl	178	13	[	[	-LRB-
cord-292688-w4zvfkyl	178	14	AlF	AlF	NNP
cord-292688-w4zvfkyl	178	15	4	4	CD
cord-292688-w4zvfkyl	178	16	]	]	-RRB-
cord-292688-w4zvfkyl	178	17	À	à	NN
cord-292688-w4zvfkyl	178	18	and	and	CC
cord-292688-w4zvfkyl	178	19	several	several	JJ
cord-292688-w4zvfkyl	178	20	other	other	JJ
cord-292688-w4zvfkyl	178	21	lines	line	NNS
cord-292688-w4zvfkyl	178	22	of	of	IN
cord-292688-w4zvfkyl	178	23	evidence	evidence	NN
cord-292688-w4zvfkyl	178	24	demonstrated	demonstrate	VBD
cord-292688-w4zvfkyl	178	25	that	that	IN
cord-292688-w4zvfkyl	178	26	heterotrimeric	heterotrimeric	NNP
cord-292688-w4zvfkyl	178	27	GTP	GTP	NNP
cord-292688-w4zvfkyl	178	28	-	-	HYPH
cord-292688-w4zvfkyl	178	29	binding	bind	VBG
cord-292688-w4zvfkyl	178	30	proteins	protein	NNS
cord-292688-w4zvfkyl	178	31	are	be	VBP
cord-292688-w4zvfkyl	178	32	involved	involve	VBN
cord-292688-w4zvfkyl	178	33	in	in	IN
cord-292688-w4zvfkyl	178	34	the	the	DT
cord-292688-w4zvfkyl	178	35	regulation	regulation	NN
cord-292688-w4zvfkyl	178	36	of	of	IN
cord-292688-w4zvfkyl	178	37	post	post	JJ
cord-292688-w4zvfkyl	178	38	-	-	JJ
cord-292688-w4zvfkyl	178	39	Golgi	golgi	JJ
cord-292688-w4zvfkyl	178	40	vesicle	vesicle	NN
cord-292688-w4zvfkyl	178	41	formation	formation	NN
cord-292688-w4zvfkyl	178	42	(	(	-LRB-
cord-292688-w4zvfkyl	178	43	see	see	VB
cord-292688-w4zvfkyl	178	44	[	[	-LRB-
cord-292688-w4zvfkyl	178	45	71	71	CD
cord-292688-w4zvfkyl	178	46	]	]	-RRB-
cord-292688-w4zvfkyl	178	47	for	for	IN
cord-292688-w4zvfkyl	178	48	review	review	NN
cord-292688-w4zvfkyl	178	49	)	)	-RRB-
cord-292688-w4zvfkyl	178	50	.	.	.
cord-292688-w4zvfkyl	179	1	The	the	DT
cord-292688-w4zvfkyl	179	2	precise	precise	JJ
cord-292688-w4zvfkyl	179	3	function	function	NN
cord-292688-w4zvfkyl	179	4	of	of	IN
cord-292688-w4zvfkyl	179	5	GTP	GTP	NNP
cord-292688-w4zvfkyl	179	6	is	be	VBZ
cord-292688-w4zvfkyl	179	7	not	not	RB
cord-292688-w4zvfkyl	179	8	yet	yet	RB
cord-292688-w4zvfkyl	179	9	clear	clear	JJ
cord-292688-w4zvfkyl	179	10	as	as	IN
cord-292688-w4zvfkyl	179	11	there	there	EX
cord-292688-w4zvfkyl	179	12	maybe	maybe	RB
cord-292688-w4zvfkyl	179	13	several	several	JJ
cord-292688-w4zvfkyl	179	14	di¡erent	di¡erent	NNP
cord-292688-w4zvfkyl	179	15	GTP	GTP	NNP
cord-292688-w4zvfkyl	179	16	-	-	HYPH
cord-292688-w4zvfkyl	179	17	binding	bind	VBG
cord-292688-w4zvfkyl	179	18	proteins	protein	NNS
cord-292688-w4zvfkyl	179	19	involved	involve	VBN
cord-292688-w4zvfkyl	179	20	in	in	IN
cord-292688-w4zvfkyl	179	21	vesicle	vesicle	NN
cord-292688-w4zvfkyl	179	22	formation	formation	NN
cord-292688-w4zvfkyl	179	23	from	from	IN
cord-292688-w4zvfkyl	179	24	the	the	DT
cord-292688-w4zvfkyl	179	25	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	179	26	,	,	,
cord-292688-w4zvfkyl	179	27	including	include	VBG
cord-292688-w4zvfkyl	179	28	ARF	arf	NN
cord-292688-w4zvfkyl	179	29	(	(	-LRB-
cord-292688-w4zvfkyl	179	30	see	see	VB
cord-292688-w4zvfkyl	179	31	below	below	RB
cord-292688-w4zvfkyl	179	32	)	)	-RRB-
cord-292688-w4zvfkyl	179	33	.	.	.
cord-292688-w4zvfkyl	180	1	An	an	DT
cord-292688-w4zvfkyl	180	2	intriguing	intriguing	JJ
cord-292688-w4zvfkyl	180	3	related	related	JJ
cord-292688-w4zvfkyl	180	4	observation	observation	NN
cord-292688-w4zvfkyl	180	5	concerns	concern	VBZ
cord-292688-w4zvfkyl	180	6	the	the	DT
cord-292688-w4zvfkyl	180	7	role	role	NN
cord-292688-w4zvfkyl	180	8	of	of	IN
cord-292688-w4zvfkyl	180	9	an	an	DT
cord-292688-w4zvfkyl	180	10	as	as	RB
cord-292688-w4zvfkyl	180	11	yet	yet	RB
cord-292688-w4zvfkyl	180	12	unidenti¢ed	unidenti¢ed	``
cord-292688-w4zvfkyl	180	13	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	180	14	phosphoprotein	phosphoprotein	NN
cord-292688-w4zvfkyl	180	15	as	as	IN
cord-292688-w4zvfkyl	180	16	a	a	DT
cord-292688-w4zvfkyl	180	17	modulator	modulator	NN
cord-292688-w4zvfkyl	180	18	of	of	IN
cord-292688-w4zvfkyl	180	19	the	the	DT
cord-292688-w4zvfkyl	180	20	heterotrimeric	heterotrimeric	NN
cord-292688-w4zvfkyl	180	21	G	G	NNP
cord-292688-w4zvfkyl	180	22	protein(s	protein(s	NNP
cord-292688-w4zvfkyl	180	23	)	)	-RRB-
cord-292688-w4zvfkyl	180	24	that	that	WDT
cord-292688-w4zvfkyl	180	25	regulate	regulate	VBP
cord-292688-w4zvfkyl	180	26	vesicle	vesicle	NN
cord-292688-w4zvfkyl	180	27	formation	formation	NN
cord-292688-w4zvfkyl	180	28	from	from	IN
cord-292688-w4zvfkyl	180	29	the	the	DT
cord-292688-w4zvfkyl	180	30	TGN	TGN	NNP
cord-292688-w4zvfkyl	180	31	[	[	-LRB-
cord-292688-w4zvfkyl	180	32	50	50	CD
cord-292688-w4zvfkyl	180	33	]	]	-RRB-
cord-292688-w4zvfkyl	180	34	.	.	.
cord-292688-w4zvfkyl	181	1	A	a	DT
cord-292688-w4zvfkyl	181	2	similar	similar	JJ
cord-292688-w4zvfkyl	181	3	requirement	requirement	NN
cord-292688-w4zvfkyl	181	4	has	have	VBZ
cord-292688-w4zvfkyl	181	5	been	be	VBN
cord-292688-w4zvfkyl	181	6	seen	see	VBN
cord-292688-w4zvfkyl	181	7	in	in	IN
cord-292688-w4zvfkyl	181	8	the	the	DT
cord-292688-w4zvfkyl	181	9	semi	semi	JJ
cord-292688-w4zvfkyl	181	10	-	-	JJ
cord-292688-w4zvfkyl	181	11	intact	intact	JJ
cord-292688-w4zvfkyl	181	12	GH	gh	NN
cord-292688-w4zvfkyl	181	13	4	4	CD
cord-292688-w4zvfkyl	181	14	C	c	NN
cord-292688-w4zvfkyl	181	15	1	1	CD
cord-292688-w4zvfkyl	181	16	in	in	IN
cord-292688-w4zvfkyl	181	17	vitro	vitro	FW
cord-292688-w4zvfkyl	181	18	assay	assay	NN
cord-292688-w4zvfkyl	181	19	[	[	-LRB-
cord-292688-w4zvfkyl	181	20	72	72	CD
cord-292688-w4zvfkyl	181	21	]	]	-RRB-
cord-292688-w4zvfkyl	181	22	in	in	IN
cord-292688-w4zvfkyl	181	23	experiments	experiment	NNS
cord-292688-w4zvfkyl	181	24	using	use	VBG
cord-292688-w4zvfkyl	181	25	inhibitors	inhibitor	NNS
cord-292688-w4zvfkyl	181	26	of	of	IN
cord-292688-w4zvfkyl	181	27	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	181	28	kinases	kinase	NNS
cord-292688-w4zvfkyl	181	29	and	and	CC
cord-292688-w4zvfkyl	181	30	phosphatases	phosphatase	NNS
cord-292688-w4zvfkyl	181	31	.	.	.
cord-292688-w4zvfkyl	182	1	This	this	DT
cord-292688-w4zvfkyl	182	2	observation	observation	NN
cord-292688-w4zvfkyl	182	3	is	be	VBZ
cord-292688-w4zvfkyl	182	4	supported	support	VBN
cord-292688-w4zvfkyl	182	5	by	by	IN
cord-292688-w4zvfkyl	182	6	several	several	JJ
cord-292688-w4zvfkyl	182	7	other	other	JJ
cord-292688-w4zvfkyl	182	8	reports	report	NNS
cord-292688-w4zvfkyl	182	9	from	from	IN
cord-292688-w4zvfkyl	182	10	cell	cell	NN
cord-292688-w4zvfkyl	182	11	-	-	HYPH
cord-292688-w4zvfkyl	182	12	free	free	JJ
cord-292688-w4zvfkyl	182	13	budding	budding	JJ
cord-292688-w4zvfkyl	182	14	assays	assay	NNS
cord-292688-w4zvfkyl	182	15	which	which	WDT
cord-292688-w4zvfkyl	182	16	indicate	indicate	VBP
cord-292688-w4zvfkyl	182	17	that	that	IN
cord-292688-w4zvfkyl	182	18	phosphorylation	phosphorylation	NN
cord-292688-w4zvfkyl	182	19	regulates	regulate	VBZ
cord-292688-w4zvfkyl	182	20	vesicle	vesicle	NN
cord-292688-w4zvfkyl	182	21	formation	formation	NN
cord-292688-w4zvfkyl	182	22	[	[	-LRB-
cord-292688-w4zvfkyl	182	23	48	48	CD
cord-292688-w4zvfkyl	182	24	,	,	,
cord-292688-w4zvfkyl	182	25	73	73	CD
cord-292688-w4zvfkyl	182	26	,	,	,
cord-292688-w4zvfkyl	182	27	74	74	CD
cord-292688-w4zvfkyl	182	28	]	]	-RRB-
cord-292688-w4zvfkyl	182	29	.	.	.
cord-292688-w4zvfkyl	183	1	A	a	DT
cord-292688-w4zvfkyl	183	2	role	role	NN
cord-292688-w4zvfkyl	183	3	for	for	IN
cord-292688-w4zvfkyl	183	4	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	183	5	-	-	HYPH
cord-292688-w4zvfkyl	183	6	phosphorylation	phosphorylation	NN
cord-292688-w4zvfkyl	183	7	in	in	IN
cord-292688-w4zvfkyl	183	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	183	9	granule	granule	NN
cord-292688-w4zvfkyl	183	10	biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	183	11	and/or	and/or	CC
cord-292688-w4zvfkyl	183	12	function	function	NN
cord-292688-w4zvfkyl	183	13	has	have	VBZ
cord-292688-w4zvfkyl	183	14	also	also	RB
cord-292688-w4zvfkyl	183	15	been	be	VBN
cord-292688-w4zvfkyl	183	16	suggested	suggest	VBN
cord-292688-w4zvfkyl	183	17	by	by	IN
cord-292688-w4zvfkyl	183	18	two	two	CD
cord-292688-w4zvfkyl	183	19	recent	recent	JJ
cord-292688-w4zvfkyl	183	20	reports	report	NNS
cord-292688-w4zvfkyl	183	21	that	that	WDT
cord-292688-w4zvfkyl	183	22	have	have	VBP
cord-292688-w4zvfkyl	183	23	iden	iden	NNP
cord-292688-w4zvfkyl	183	24	-	-	HYPH
cord-292688-w4zvfkyl	183	25	ti¢ed	ti¢ed	NNP
cord-292688-w4zvfkyl	183	26	two	two	CD
cord-292688-w4zvfkyl	183	27	highly	highly	RB
cord-292688-w4zvfkyl	183	28	homologous	homologous	JJ
cord-292688-w4zvfkyl	183	29	proteins	protein	NNS
cord-292688-w4zvfkyl	183	30	in	in	IN
cord-292688-w4zvfkyl	183	31	the	the	DT
cord-292688-w4zvfkyl	183	32	membrane	membrane	NN
cord-292688-w4zvfkyl	183	33	of	of	IN
cord-292688-w4zvfkyl	183	34	secretory	secretory	JJ
cord-292688-w4zvfkyl	183	35	granules	granule	NNS
cord-292688-w4zvfkyl	183	36	which	which	WDT
cord-292688-w4zvfkyl	183	37	appear	appear	VBP
cord-292688-w4zvfkyl	183	38	to	to	TO
cord-292688-w4zvfkyl	183	39	be	be	VB
cord-292688-w4zvfkyl	183	40	nonfunctional	nonfunctional	JJ
cord-292688-w4zvfkyl	183	41	protein	protein	NN
cord-292688-w4zvfkyl	183	42	-	-	HYPH
cord-292688-w4zvfkyl	183	43	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	183	44	phosphatases	phosphatase	NNS
cord-292688-w4zvfkyl	183	45	,	,	,
cord-292688-w4zvfkyl	183	46	called	call	VBD
cord-292688-w4zvfkyl	183	47	phogrin	phogrin	NNP
cord-292688-w4zvfkyl	183	48	and	and	CC
cord-292688-w4zvfkyl	183	49	the	the	DT
cord-292688-w4zvfkyl	183	50	ICA	ICA	NNP
cord-292688-w4zvfkyl	183	51	512	512	CD
cord-292688-w4zvfkyl	183	52	autoantigen	autoantigen	NN
cord-292688-w4zvfkyl	183	53	[	[	-LRB-
cord-292688-w4zvfkyl	183	54	75	75	CD
cord-292688-w4zvfkyl	183	55	,	,	,
cord-292688-w4zvfkyl	183	56	76	76	CD
cord-292688-w4zvfkyl	183	57	]	]	-RRB-
cord-292688-w4zvfkyl	183	58	.	.	.
cord-292688-w4zvfkyl	184	1	Most	Most	JJS
cord-292688-w4zvfkyl	184	2	of	of	IN
cord-292688-w4zvfkyl	184	3	the	the	DT
cord-292688-w4zvfkyl	184	4	well	well	RB
cord-292688-w4zvfkyl	184	5	characterized	characterize	VBN
cord-292688-w4zvfkyl	184	6	transport	transport	NN
cord-292688-w4zvfkyl	184	7	steps	step	NNS
cord-292688-w4zvfkyl	184	8	in	in	IN
cord-292688-w4zvfkyl	184	9	the	the	DT
cord-292688-w4zvfkyl	184	10	cell	cell	NN
cord-292688-w4zvfkyl	184	11	(	(	-LRB-
cord-292688-w4zvfkyl	184	12	for	for	IN
cord-292688-w4zvfkyl	184	13	example	example	NN
cord-292688-w4zvfkyl	184	14	from	from	IN
cord-292688-w4zvfkyl	184	15	the	the	DT
cord-292688-w4zvfkyl	184	16	endoplasmic	endoplasmic	NN
cord-292688-w4zvfkyl	184	17	reticulum	reticulum	NN
cord-292688-w4zvfkyl	184	18	to	to	IN
cord-292688-w4zvfkyl	184	19	the	the	DT
cord-292688-w4zvfkyl	184	20	cis	cis	NNP
cord-292688-w4zvfkyl	184	21	-	-	HYPH
cord-292688-w4zvfkyl	184	22	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	184	23	,	,	,
cord-292688-w4zvfkyl	184	24	intra	intra	JJ
cord-292688-w4zvfkyl	184	25	-	-	JJ
cord-292688-w4zvfkyl	184	26	Golgi	golgi	JJ
cord-292688-w4zvfkyl	184	27	,	,	,
cord-292688-w4zvfkyl	184	28	plasma	plasma	NN
cord-292688-w4zvfkyl	184	29	membrane	membrane	NN
cord-292688-w4zvfkyl	184	30	to	to	IN
cord-292688-w4zvfkyl	184	31	endosome	endosome	NN
cord-292688-w4zvfkyl	184	32	)	)	-RRB-
cord-292688-w4zvfkyl	184	33	have	have	VBP
cord-292688-w4zvfkyl	184	34	been	be	VBN
cord-292688-w4zvfkyl	184	35	shown	show	VBN
cord-292688-w4zvfkyl	184	36	to	to	TO
cord-292688-w4zvfkyl	184	37	be	be	VB
cord-292688-w4zvfkyl	184	38	mediated	mediate	VBN
cord-292688-w4zvfkyl	184	39	by	by	IN
cord-292688-w4zvfkyl	184	40	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	184	41	which	which	WDT
cord-292688-w4zvfkyl	184	42	form	form	VBP
cord-292688-w4zvfkyl	184	43	by	by	IN
cord-292688-w4zvfkyl	184	44	coat	coat	NN
cord-292688-w4zvfkyl	184	45	-	-	HYPH
cord-292688-w4zvfkyl	184	46	mediated	mediate	VBN
cord-292688-w4zvfkyl	184	47	budding	budding	JJ
cord-292688-w4zvfkyl	184	48	reactions	reaction	NNS
cord-292688-w4zvfkyl	184	49	from	from	IN
cord-292688-w4zvfkyl	184	50	donor	donor	NN
cord-292688-w4zvfkyl	184	51	compartments	compartment	NNS
cord-292688-w4zvfkyl	184	52	.	.	.
cord-292688-w4zvfkyl	185	1	In	in	IN
cord-292688-w4zvfkyl	185	2	contrast	contrast	NN
cord-292688-w4zvfkyl	185	3	no	no	DT
cord-292688-w4zvfkyl	185	4	known	know	VBN
cord-292688-w4zvfkyl	185	5	coat	coat	NN
cord-292688-w4zvfkyl	185	6	,	,	,
cord-292688-w4zvfkyl	185	7	or	or	CC
cord-292688-w4zvfkyl	185	8	coat	coat	NN
cord-292688-w4zvfkyl	185	9	protein	protein	NN
cord-292688-w4zvfkyl	185	10	,	,	,
cord-292688-w4zvfkyl	185	11	has	have	VBZ
cord-292688-w4zvfkyl	185	12	been	be	VBN
cord-292688-w4zvfkyl	185	13	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	185	14	by	by	IN
cord-292688-w4zvfkyl	185	15	morphological	morphological	JJ
cord-292688-w4zvfkyl	185	16	or	or	CC
cord-292688-w4zvfkyl	185	17	biochemical	biochemical	JJ
cord-292688-w4zvfkyl	185	18	techniques	technique	NNS
cord-292688-w4zvfkyl	185	19	to	to	TO
cord-292688-w4zvfkyl	185	20	be	be	VB
cord-292688-w4zvfkyl	185	21	involved	involve	VBN
cord-292688-w4zvfkyl	185	22	in	in	IN
cord-292688-w4zvfkyl	185	23	secretory	secretory	JJ
cord-292688-w4zvfkyl	185	24	granule	granule	NN
cord-292688-w4zvfkyl	185	25	formation	formation	NN
cord-292688-w4zvfkyl	185	26	.	.	.
cord-292688-w4zvfkyl	186	1	As	as	IN
cord-292688-w4zvfkyl	186	2	mentioned	mention	VBN
cord-292688-w4zvfkyl	186	3	above	above	RB
cord-292688-w4zvfkyl	186	4	,	,	,
cord-292688-w4zvfkyl	186	5	if	if	IN
cord-292688-w4zvfkyl	186	6	a	a	DT
cord-292688-w4zvfkyl	186	7	coat	coat	NN
cord-292688-w4zvfkyl	186	8	were	be	VBD
cord-292688-w4zvfkyl	186	9	required	require	VBN
cord-292688-w4zvfkyl	186	10	,	,	,
cord-292688-w4zvfkyl	186	11	the	the	DT
cord-292688-w4zvfkyl	186	12	most	most	RBS
cord-292688-w4zvfkyl	186	13	likely	likely	JJ
cord-292688-w4zvfkyl	186	14	coat	coat	NN
cord-292688-w4zvfkyl	186	15	protein	protein	NN
cord-292688-w4zvfkyl	186	16	candidate	candidate	NN
cord-292688-w4zvfkyl	186	17	would	would	MD
cord-292688-w4zvfkyl	186	18	be	be	VB
cord-292688-w4zvfkyl	186	19	clathrin	clathrin	NNP
cord-292688-w4zvfkyl	186	20	.	.	.
cord-292688-w4zvfkyl	187	1	Formation	formation	NN
cord-292688-w4zvfkyl	187	2	of	of	IN
cord-292688-w4zvfkyl	187	3	clathrin	clathrin	NN
cord-292688-w4zvfkyl	187	4	-	-	HYPH
cord-292688-w4zvfkyl	187	5	coats	coat	NNS
cord-292688-w4zvfkyl	187	6	on	on	IN
cord-292688-w4zvfkyl	187	7	the	the	DT
cord-292688-w4zvfkyl	187	8	TGN	TGN	NNP
cord-292688-w4zvfkyl	187	9	requires	require	VBZ
cord-292688-w4zvfkyl	187	10	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	187	11	(	(	-LRB-
cord-292688-w4zvfkyl	187	12	see	see	VB
cord-292688-w4zvfkyl	187	13	above	above	RB
cord-292688-w4zvfkyl	187	14	)	)	-RRB-
cord-292688-w4zvfkyl	187	15	and	and	CC
cord-292688-w4zvfkyl	187	16	the	the	DT
cord-292688-w4zvfkyl	187	17	monomeric	monomeric	JJ
cord-292688-w4zvfkyl	187	18	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	187	19	ADP	ADP	NNP
cord-292688-w4zvfkyl	187	20	-	-	HYPH
cord-292688-w4zvfkyl	187	21	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	187	22	factor	factor	NN
cord-292688-w4zvfkyl	187	23	,	,	,
cord-292688-w4zvfkyl	187	24	or	or	CC
cord-292688-w4zvfkyl	187	25	ARF	ARF	NNP
cord-292688-w4zvfkyl	187	26	[	[	-LRB-
cord-292688-w4zvfkyl	187	27	77	77	CD
cord-292688-w4zvfkyl	187	28	,	,	,
cord-292688-w4zvfkyl	187	29	78	78	CD
cord-292688-w4zvfkyl	187	30	]	]	-RRB-
cord-292688-w4zvfkyl	187	31	and	and	CC
cord-292688-w4zvfkyl	187	32	these	these	DT
cord-292688-w4zvfkyl	187	33	components	component	NNS
cord-292688-w4zvfkyl	187	34	might	may	MD
cord-292688-w4zvfkyl	187	35	therefore	therefore	RB
cord-292688-w4zvfkyl	187	36	be	be	VB
cord-292688-w4zvfkyl	187	37	thought	think	VBN
cord-292688-w4zvfkyl	187	38	to	to	TO
cord-292688-w4zvfkyl	187	39	function	function	VB
cord-292688-w4zvfkyl	187	40	in	in	IN
cord-292688-w4zvfkyl	187	41	the	the	DT
cord-292688-w4zvfkyl	187	42	formation	formation	NN
cord-292688-w4zvfkyl	187	43	of	of	IN
cord-292688-w4zvfkyl	187	44	secretory	secretory	JJ
cord-292688-w4zvfkyl	187	45	granules	granule	NNS
cord-292688-w4zvfkyl	187	46	.	.	.
cord-292688-w4zvfkyl	188	1	However	however	RB
cord-292688-w4zvfkyl	188	2	,	,	,
cord-292688-w4zvfkyl	188	3	to	to	IN
cord-292688-w4zvfkyl	188	4	date	date	NN
cord-292688-w4zvfkyl	188	5	there	there	EX
cord-292688-w4zvfkyl	188	6	is	be	VBZ
cord-292688-w4zvfkyl	188	7	no	no	DT
cord-292688-w4zvfkyl	188	8	evidence	evidence	NN
cord-292688-w4zvfkyl	188	9	which	which	WDT
cord-292688-w4zvfkyl	188	10	implicates	implicate	VBZ
cord-292688-w4zvfkyl	188	11	clathrin	clathrin	NN
cord-292688-w4zvfkyl	188	12	in	in	IN
cord-292688-w4zvfkyl	188	13	the	the	DT
cord-292688-w4zvfkyl	188	14	formation	formation	NN
cord-292688-w4zvfkyl	188	15	of	of	IN
cord-292688-w4zvfkyl	188	16	either	either	DT
cord-292688-w4zvfkyl	188	17	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	188	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	188	19	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	188	20	or	or	CC
cord-292688-w4zvfkyl	188	21	secretory	secretory	JJ
cord-292688-w4zvfkyl	188	22	granules	granule	NNS
cord-292688-w4zvfkyl	188	23	from	from	IN
cord-292688-w4zvfkyl	188	24	the	the	DT
cord-292688-w4zvfkyl	188	25	TGN	TGN	NNP
cord-292688-w4zvfkyl	188	26	.	.	.
cord-292688-w4zvfkyl	189	1	On	on	IN
cord-292688-w4zvfkyl	189	2	the	the	DT
cord-292688-w4zvfkyl	189	3	other	other	JJ
cord-292688-w4zvfkyl	189	4	hand	hand	NN
cord-292688-w4zvfkyl	189	5	,	,	,
cord-292688-w4zvfkyl	189	6	reports	report	VBZ
cord-292688-w4zvfkyl	189	7	from	from	IN
cord-292688-w4zvfkyl	189	8	the	the	DT
cord-292688-w4zvfkyl	189	9	two	two	CD
cord-292688-w4zvfkyl	189	10	cell	cell	NN
cord-292688-w4zvfkyl	189	11	-	-	HYPH
cord-292688-w4zvfkyl	189	12	free	free	JJ
cord-292688-w4zvfkyl	189	13	assays	assay	NNS
cord-292688-w4zvfkyl	189	14	described	describe	VBN
cord-292688-w4zvfkyl	189	15	above	above	RB
cord-292688-w4zvfkyl	189	16	have	have	VBP
cord-292688-w4zvfkyl	189	17	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	189	18	that	that	IN
cord-292688-w4zvfkyl	189	19	ARF	ARF	NNP
cord-292688-w4zvfkyl	189	20	is	be	VBZ
cord-292688-w4zvfkyl	189	21	required	require	VBN
cord-292688-w4zvfkyl	189	22	for	for	IN
cord-292688-w4zvfkyl	189	23	the	the	DT
cord-292688-w4zvfkyl	189	24	budding	budding	NN
cord-292688-w4zvfkyl	189	25	of	of	IN
cord-292688-w4zvfkyl	189	26	secretory	secretory	JJ
cord-292688-w4zvfkyl	189	27	granules	granule	NNS
cord-292688-w4zvfkyl	189	28	and	and	CC
cord-292688-w4zvfkyl	189	29	post	post	JJ
cord-292688-w4zvfkyl	189	30	-	-	JJ
cord-292688-w4zvfkyl	189	31	TGN	tgn	JJ
cord-292688-w4zvfkyl	189	32	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	189	33	.	.	.
cord-292688-w4zvfkyl	190	1	Myristoylated	Myristoylated	NNP
cord-292688-w4zvfkyl	190	2	ARF1	ARF1	NNP
cord-292688-w4zvfkyl	190	3	peptide	peptide	NN
cord-292688-w4zvfkyl	190	4	stimulated	stimulate	VBD
cord-292688-w4zvfkyl	190	5	both	both	CC
cord-292688-w4zvfkyl	190	6	the	the	DT
cord-292688-w4zvfkyl	190	7	formation	formation	NN
cord-292688-w4zvfkyl	190	8	of	of	IN
cord-292688-w4zvfkyl	190	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	190	10	granules	granule	NNS
cord-292688-w4zvfkyl	190	11	and	and	CC
cord-292688-w4zvfkyl	190	12	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	190	13	secretory	secretory	JJ
cord-292688-w4zvfkyl	190	14	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	190	15	from	from	IN
cord-292688-w4zvfkyl	190	16	isolated	isolate	VBN
cord-292688-w4zvfkyl	190	17	TGN	TGN	NNP
cord-292688-w4zvfkyl	190	18	membranes	membrane	NNS
cord-292688-w4zvfkyl	190	19	[	[	-LRB-
cord-292688-w4zvfkyl	190	20	51	51	CD
cord-292688-w4zvfkyl	190	21	]	]	-RRB-
cord-292688-w4zvfkyl	190	22	,	,	,
cord-292688-w4zvfkyl	190	23	while	while	IN
cord-292688-w4zvfkyl	190	24	in	in	IN
cord-292688-w4zvfkyl	190	25	a	a	DT
cord-292688-w4zvfkyl	190	26	semi	semi	JJ
cord-292688-w4zvfkyl	190	27	-	-	JJ
cord-292688-w4zvfkyl	190	28	intact	intact	JJ
cord-292688-w4zvfkyl	190	29	cell	cell	NN
cord-292688-w4zvfkyl	190	30	system	system	NN
cord-292688-w4zvfkyl	190	31	[	[	-LRB-
cord-292688-w4zvfkyl	190	32	52	52	CD
cord-292688-w4zvfkyl	190	33	]	]	-RRB-
cord-292688-w4zvfkyl	191	1	ARF1	ARF1	NNP
cord-292688-w4zvfkyl	191	2	peptide	peptide	NN
cord-292688-w4zvfkyl	191	3	was	be	VBD
cord-292688-w4zvfkyl	191	4	su¤cient	su¤cient	NNP
cord-292688-w4zvfkyl	191	5	for	for	IN
cord-292688-w4zvfkyl	191	6	stimulation	stimulation	NN
cord-292688-w4zvfkyl	191	7	of	of	IN
cord-292688-w4zvfkyl	191	8	budding	bud	VBG
cord-292688-w4zvfkyl	191	9	of	of	IN
cord-292688-w4zvfkyl	191	10	GH	GH	NNP
cord-292688-w4zvfkyl	191	11	-	-	HYPH
cord-292688-w4zvfkyl	191	12	and	and	CC
cord-292688-w4zvfkyl	191	13	PRL	PRL	NNP
cord-292688-w4zvfkyl	191	14	-	-	HYPH
cord-292688-w4zvfkyl	191	15	containing	contain	VBG
cord-292688-w4zvfkyl	191	16	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	191	17	.	.	.
cord-292688-w4zvfkyl	192	1	Importantly	importantly	RB
cord-292688-w4zvfkyl	192	2	,	,	,
cord-292688-w4zvfkyl	192	3	although	although	IN
cord-292688-w4zvfkyl	192	4	ARF	ARF	NNP
cord-292688-w4zvfkyl	192	5	is	be	VBZ
cord-292688-w4zvfkyl	192	6	known	know	VBN
cord-292688-w4zvfkyl	192	7	to	to	TO
cord-292688-w4zvfkyl	192	8	be	be	VB
cord-292688-w4zvfkyl	192	9	involved	involve	VBN
cord-292688-w4zvfkyl	192	10	in	in	IN
cord-292688-w4zvfkyl	192	11	the	the	DT
cord-292688-w4zvfkyl	192	12	recruitment	recruitment	NN
cord-292688-w4zvfkyl	192	13	of	of	IN
cord-292688-w4zvfkyl	192	14	COP	cop	NN
cord-292688-w4zvfkyl	192	15	I	-PRON-	PRP
cord-292688-w4zvfkyl	192	16	coats	coat	VBZ
cord-292688-w4zvfkyl	192	17	to	to	IN
cord-292688-w4zvfkyl	192	18	membranes	membrane	NNS
cord-292688-w4zvfkyl	192	19	(	(	-LRB-
cord-292688-w4zvfkyl	192	20	see	see	VB
cord-292688-w4zvfkyl	192	21	article	article	NN
cord-292688-w4zvfkyl	192	22	by	by	IN
cord-292688-w4zvfkyl	192	23	EMR	EMR	NNP
cord-292688-w4zvfkyl	192	24	in	in	IN
cord-292688-w4zvfkyl	192	25	this	this	DT
cord-292688-w4zvfkyl	192	26	issue	issue	NN
cord-292688-w4zvfkyl	192	27	)	)	-RRB-
cord-292688-w4zvfkyl	192	28	,	,	,
cord-292688-w4zvfkyl	192	29	Barr	Barr	NNP
cord-292688-w4zvfkyl	192	30	and	and	CC
cord-292688-w4zvfkyl	192	31	Huttner	Huttner	NNP
cord-292688-w4zvfkyl	192	32	[	[	-LRB-
cord-292688-w4zvfkyl	192	33	51	51	CD
cord-292688-w4zvfkyl	192	34	]	]	-RRB-
cord-292688-w4zvfkyl	192	35	could	could	MD
cord-292688-w4zvfkyl	192	36	demonstrate	demonstrate	VB
cord-292688-w4zvfkyl	192	37	that	that	IN
cord-292688-w4zvfkyl	192	38	depletion	depletion	NN
cord-292688-w4zvfkyl	192	39	of	of	IN
cord-292688-w4zvfkyl	192	40	COP	cop	NN
cord-292688-w4zvfkyl	193	1	I	-PRON-	PRP
cord-292688-w4zvfkyl	193	2	from	from	IN
cord-292688-w4zvfkyl	193	3	cytosol	cytosol	NN
cord-292688-w4zvfkyl	193	4	did	do	VBD
cord-292688-w4zvfkyl	193	5	not	not	RB
cord-292688-w4zvfkyl	193	6	inhibit	inhibit	VB
cord-292688-w4zvfkyl	193	7	post	post	JJ
cord-292688-w4zvfkyl	193	8	-	-	JJ
cord-292688-w4zvfkyl	193	9	Golgi	golgi	JJ
cord-292688-w4zvfkyl	193	10	vesicle	vesicle	NN
cord-292688-w4zvfkyl	193	11	formation	formation	NN
cord-292688-w4zvfkyl	193	12	.	.	.
cord-292688-w4zvfkyl	194	1	Several	several	JJ
cord-292688-w4zvfkyl	194	2	reports	report	NNS
cord-292688-w4zvfkyl	194	3	have	have	VBP
cord-292688-w4zvfkyl	194	4	recently	recently	RB
cord-292688-w4zvfkyl	194	5	demonstrated	demonstrate	VBN
cord-292688-w4zvfkyl	194	6	that	that	IN
cord-292688-w4zvfkyl	194	7	ARF	ARF	NNP
cord-292688-w4zvfkyl	194	8	may	may	MD
cord-292688-w4zvfkyl	194	9	function	function	VB
cord-292688-w4zvfkyl	194	10	by	by	IN
cord-292688-w4zvfkyl	194	11	activating	activate	VBG
cord-292688-w4zvfkyl	194	12	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	194	13	D	d	NN
cord-292688-w4zvfkyl	194	14	(	(	-LRB-
cord-292688-w4zvfkyl	194	15	[	[	-LRB-
cord-292688-w4zvfkyl	194	16	79	79	CD
cord-292688-w4zvfkyl	194	17	^	^	SYM
cord-292688-w4zvfkyl	194	18	81	81	CD
cord-292688-w4zvfkyl	194	19	]	]	-RRB-
cord-292688-w4zvfkyl	194	20	and	and	CC
cord-292688-w4zvfkyl	194	21	see	see	VB
cord-292688-w4zvfkyl	194	22	[	[	-LRB-
cord-292688-w4zvfkyl	194	23	82	82	CD
cord-292688-w4zvfkyl	194	24	]	]	-RRB-
cord-292688-w4zvfkyl	194	25	for	for	IN
cord-292688-w4zvfkyl	194	26	review	review	NN
cord-292688-w4zvfkyl	194	27	)	)	-RRB-
cord-292688-w4zvfkyl	194	28	.	.	.
cord-292688-w4zvfkyl	195	1	Interestingly	interestingly	RB
cord-292688-w4zvfkyl	195	2	,	,	,
cord-292688-w4zvfkyl	195	3	addition	addition	NN
cord-292688-w4zvfkyl	195	4	of	of	IN
cord-292688-w4zvfkyl	195	5	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	195	6	D	D	NNP
cord-292688-w4zvfkyl	195	7	(	(	-LRB-
cord-292688-w4zvfkyl	195	8	PLD	PLD	NNP
cord-292688-w4zvfkyl	195	9	)	)	-RRB-
cord-292688-w4zvfkyl	195	10	has	have	VBZ
cord-292688-w4zvfkyl	195	11	been	be	VBN
cord-292688-w4zvfkyl	195	12	shown	show	VBN
cord-292688-w4zvfkyl	195	13	to	to	TO
cord-292688-w4zvfkyl	195	14	stimulate	stimulate	VB
cord-292688-w4zvfkyl	195	15	budding	bud	VBG
cord-292688-w4zvfkyl	195	16	from	from	IN
cord-292688-w4zvfkyl	195	17	the	the	DT
cord-292688-w4zvfkyl	195	18	TGN	TGN	NNP
cord-292688-w4zvfkyl	195	19	in	in	IN
cord-292688-w4zvfkyl	195	20	the	the	DT
cord-292688-w4zvfkyl	195	21	semi	semi	JJ
cord-292688-w4zvfkyl	195	22	-	-	JJ
cord-292688-w4zvfkyl	195	23	intact	intact	JJ
cord-292688-w4zvfkyl	195	24	assay	assay	NN
cord-292688-w4zvfkyl	195	25	using	use	VBG
cord-292688-w4zvfkyl	195	26	GH	GH	NNP
cord-292688-w4zvfkyl	195	27	4	4	CD
cord-292688-w4zvfkyl	195	28	C1	C1	NNP
cord-292688-w4zvfkyl	195	29	cells	cell	NNS
cord-292688-w4zvfkyl	195	30	[	[	-LRB-
cord-292688-w4zvfkyl	195	31	83	83	CD
cord-292688-w4zvfkyl	195	32	]	]	-RRB-
cord-292688-w4zvfkyl	195	33	.	.	.
cord-292688-w4zvfkyl	196	1	The	the	DT
cord-292688-w4zvfkyl	196	2	stimulatory	stimulatory	JJ
cord-292688-w4zvfkyl	196	3	e¡ect	e¡ect	NN
cord-292688-w4zvfkyl	196	4	of	of	IN
cord-292688-w4zvfkyl	196	5	PLD	PLD	NNP
cord-292688-w4zvfkyl	196	6	might	may	MD
cord-292688-w4zvfkyl	196	7	be	be	VB
cord-292688-w4zvfkyl	196	8	attributed	attribute	VBN
cord-292688-w4zvfkyl	196	9	to	to	IN
cord-292688-w4zvfkyl	196	10	its	-PRON-	PRP$
cord-292688-w4zvfkyl	196	11	ability	ability	NN
cord-292688-w4zvfkyl	196	12	to	to	TO
cord-292688-w4zvfkyl	196	13	catalyse	catalyse	VB
cord-292688-w4zvfkyl	196	14	the	the	DT
cord-292688-w4zvfkyl	196	15	hydrolysis	hydrolysis	NN
cord-292688-w4zvfkyl	196	16	of	of	IN
cord-292688-w4zvfkyl	196	17	PC	pc	NN
cord-292688-w4zvfkyl	196	18	to	to	IN
cord-292688-w4zvfkyl	196	19	PA	PA	NNP
cord-292688-w4zvfkyl	196	20	and	and	CC
cord-292688-w4zvfkyl	196	21	alter	alter	VB
cord-292688-w4zvfkyl	196	22	the	the	DT
cord-292688-w4zvfkyl	196	23	lipid	lipid	NN
cord-292688-w4zvfkyl	196	24	composition	composition	NN
cord-292688-w4zvfkyl	196	25	of	of	IN
cord-292688-w4zvfkyl	196	26	the	the	DT
cord-292688-w4zvfkyl	196	27	membrane	membrane	NN
cord-292688-w4zvfkyl	196	28	.	.	.
cord-292688-w4zvfkyl	197	1	This	this	DT
cord-292688-w4zvfkyl	197	2	local	local	JJ
cord-292688-w4zvfkyl	197	3	increase	increase	NN
cord-292688-w4zvfkyl	197	4	in	in	IN
cord-292688-w4zvfkyl	197	5	charged	charge	VBN
cord-292688-w4zvfkyl	197	6	lipids	lipid	NNS
cord-292688-w4zvfkyl	197	7	has	have	VBZ
cord-292688-w4zvfkyl	197	8	been	be	VBN
cord-292688-w4zvfkyl	197	9	proposed	propose	VBN
cord-292688-w4zvfkyl	197	10	to	to	TO
cord-292688-w4zvfkyl	197	11	function	function	VB
cord-292688-w4zvfkyl	197	12	to	to	TO
cord-292688-w4zvfkyl	197	13	stabilize	stabilize	VB
cord-292688-w4zvfkyl	197	14	AP-2	AP-2	NNP
cord-292688-w4zvfkyl	197	15	association	association	NNP
cord-292688-w4zvfkyl	197	16	with	with	IN
cord-292688-w4zvfkyl	197	17	endosomal	endosomal	NNP
cord-292688-w4zvfkyl	197	18	membranes	membrane	NNS
cord-292688-w4zvfkyl	197	19	[	[	-LRB-
cord-292688-w4zvfkyl	197	20	84	84	CD
cord-292688-w4zvfkyl	197	21	]	]	-RRB-
cord-292688-w4zvfkyl	197	22	.	.	.
cord-292688-w4zvfkyl	198	1	Alternatively	alternatively	RB
cord-292688-w4zvfkyl	198	2	,	,	,
cord-292688-w4zvfkyl	198	3	the	the	DT
cord-292688-w4zvfkyl	198	4	production	production	NN
cord-292688-w4zvfkyl	198	5	of	of	IN
cord-292688-w4zvfkyl	198	6	PA	PA	NNP
cord-292688-w4zvfkyl	198	7	may	may	MD
cord-292688-w4zvfkyl	198	8	have	have	VB
cord-292688-w4zvfkyl	198	9	several	several	JJ
cord-292688-w4zvfkyl	198	10	consequences	consequence	NNS
cord-292688-w4zvfkyl	198	11	including	include	VBG
cord-292688-w4zvfkyl	198	12	the	the	DT
cord-292688-w4zvfkyl	198	13	production	production	NN
cord-292688-w4zvfkyl	198	14	of	of	IN
cord-292688-w4zvfkyl	198	15	PIP	PIP	NNP
cord-292688-w4zvfkyl	198	16	2	2	CD
cord-292688-w4zvfkyl	198	17	(	(	-LRB-
cord-292688-w4zvfkyl	198	18	phosphatidylinositol	phosphatidylinositol	NNP
cord-292688-w4zvfkyl	198	19	4,5-bisphosphate	4,5-bisphosphate	CD
cord-292688-w4zvfkyl	198	20	)	)	-RRB-
cord-292688-w4zvfkyl	198	21	in	in	IN
cord-292688-w4zvfkyl	198	22	the	the	DT
cord-292688-w4zvfkyl	198	23	membrane	membrane	NN
cord-292688-w4zvfkyl	198	24	[	[	-LRB-
cord-292688-w4zvfkyl	198	25	85	85	CD
cord-292688-w4zvfkyl	198	26	]	]	-RRB-
cord-292688-w4zvfkyl	198	27	.	.	.
cord-292688-w4zvfkyl	199	1	PIP	PIP	NNP
cord-292688-w4zvfkyl	199	2	2	2	CD
cord-292688-w4zvfkyl	199	3	has	have	VBZ
cord-292688-w4zvfkyl	199	4	been	be	VBN
cord-292688-w4zvfkyl	199	5	implicated	implicate	VBN
cord-292688-w4zvfkyl	199	6	in	in	IN
cord-292688-w4zvfkyl	199	7	a	a	DT
cord-292688-w4zvfkyl	199	8	variety	variety	NN
cord-292688-w4zvfkyl	199	9	of	of	IN
cord-292688-w4zvfkyl	199	10	membrane	membrane	NN
cord-292688-w4zvfkyl	199	11	tra¤c	tra¤c	NNP
cord-292688-w4zvfkyl	199	12	events	event	NNS
cord-292688-w4zvfkyl	199	13	[	[	-LRB-
cord-292688-w4zvfkyl	199	14	86	86	CD
cord-292688-w4zvfkyl	199	15	]	]	-RRB-
cord-292688-w4zvfkyl	199	16	and	and	CC
cord-292688-w4zvfkyl	199	17	has	have	VBZ
cord-292688-w4zvfkyl	199	18	been	be	VBN
cord-292688-w4zvfkyl	199	19	shown	show	VBN
cord-292688-w4zvfkyl	199	20	to	to	TO
cord-292688-w4zvfkyl	199	21	regulate	regulate	VB
cord-292688-w4zvfkyl	199	22	the	the	DT
cord-292688-w4zvfkyl	199	23	nucleotide	nucleotide	NN
cord-292688-w4zvfkyl	199	24	bound	bind	VBN
cord-292688-w4zvfkyl	199	25	state	state	NN
cord-292688-w4zvfkyl	199	26	of	of	IN
cord-292688-w4zvfkyl	199	27	ARF	arf	NN
cord-292688-w4zvfkyl	199	28	[	[	-LRB-
cord-292688-w4zvfkyl	199	29	87	87	CD
cord-292688-w4zvfkyl	199	30	,	,	,
cord-292688-w4zvfkyl	199	31	88	88	CD
cord-292688-w4zvfkyl	199	32	]	]	-RRB-
cord-292688-w4zvfkyl	199	33	and	and	CC
cord-292688-w4zvfkyl	199	34	to	to	TO
cord-292688-w4zvfkyl	199	35	stimulate	stimulate	VB
cord-292688-w4zvfkyl	199	36	PLD	PLD	NNP
cord-292688-w4zvfkyl	199	37	activity	activity	NN
cord-292688-w4zvfkyl	199	38	[	[	-LRB-
cord-292688-w4zvfkyl	199	39	89	89	CD
cord-292688-w4zvfkyl	199	40	]	]	-RRB-
cord-292688-w4zvfkyl	199	41	leading	lead	VBG
cord-292688-w4zvfkyl	199	42	to	to	IN
cord-292688-w4zvfkyl	199	43	a	a	DT
cord-292688-w4zvfkyl	199	44	feedback	feedback	NN
cord-292688-w4zvfkyl	199	45	cycle	cycle	NN
cord-292688-w4zvfkyl	199	46	of	of	IN
cord-292688-w4zvfkyl	199	47	interactions	interaction	NNS
cord-292688-w4zvfkyl	199	48	between	between	IN
cord-292688-w4zvfkyl	199	49	ARF	ARF	NNP
cord-292688-w4zvfkyl	199	50	,	,	,
cord-292688-w4zvfkyl	199	51	PLD	PLD	NNP
cord-292688-w4zvfkyl	199	52	,	,	,
cord-292688-w4zvfkyl	199	53	PA	PA	NNP
cord-292688-w4zvfkyl	199	54	and	and	CC
cord-292688-w4zvfkyl	199	55	PIP	PIP	NNP
cord-292688-w4zvfkyl	199	56	2	2	CD
cord-292688-w4zvfkyl	199	57	.	.	.
cord-292688-w4zvfkyl	200	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	200	2	has	have	VBZ
cord-292688-w4zvfkyl	200	3	been	be	VBN
cord-292688-w4zvfkyl	200	4	proposed	propose	VBN
cord-292688-w4zvfkyl	200	5	[	[	-LRB-
cord-292688-w4zvfkyl	200	6	83	83	CD
cord-292688-w4zvfkyl	200	7	]	]	-RRB-
cord-292688-w4zvfkyl	200	8	that	that	IN
cord-292688-w4zvfkyl	200	9	the	the	DT
cord-292688-w4zvfkyl	200	10	e¡ect	e¡ect	XX
cord-292688-w4zvfkyl	200	11	of	of	IN
cord-292688-w4zvfkyl	200	12	ARF	ARF	NNP
cord-292688-w4zvfkyl	200	13	and	and	CC
cord-292688-w4zvfkyl	200	14	PLD	PLD	NNP
cord-292688-w4zvfkyl	200	15	on	on	IN
cord-292688-w4zvfkyl	200	16	budding	bud	VBG
cord-292688-w4zvfkyl	200	17	might	may	MD
cord-292688-w4zvfkyl	200	18	alter	alter	VB
cord-292688-w4zvfkyl	200	19	-	-	:
cord-292688-w4zvfkyl	200	20	natively	natively	RB
cord-292688-w4zvfkyl	200	21	be	be	VB
cord-292688-w4zvfkyl	200	22	to	to	TO
cord-292688-w4zvfkyl	200	23	recruit	recruit	VB
cord-292688-w4zvfkyl	200	24	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	200	25	to	to	IN
cord-292688-w4zvfkyl	200	26	regions	region	NNS
cord-292688-w4zvfkyl	200	27	of	of	IN
cord-292688-w4zvfkyl	200	28	the	the	DT
cord-292688-w4zvfkyl	200	29	membrane	membrane	NN
cord-292688-w4zvfkyl	200	30	which	which	WDT
cord-292688-w4zvfkyl	200	31	are	be	VBP
cord-292688-w4zvfkyl	200	32	high	high	JJ
cord-292688-w4zvfkyl	200	33	in	in	IN
cord-292688-w4zvfkyl	200	34	PA	PA	NNP
cord-292688-w4zvfkyl	200	35	.	.	.
cord-292688-w4zvfkyl	201	1	However	however	RB
cord-292688-w4zvfkyl	201	2	,	,	,
cord-292688-w4zvfkyl	201	3	from	from	IN
cord-292688-w4zvfkyl	201	4	more	more	JJR
cord-292688-w4zvfkyl	201	5	recent	recent	JJ
cord-292688-w4zvfkyl	201	6	experiments	experiment	NNS
cord-292688-w4zvfkyl	201	7	we	-PRON-	PRP
cord-292688-w4zvfkyl	201	8	now	now	RB
cord-292688-w4zvfkyl	201	9	know	know	VBP
cord-292688-w4zvfkyl	201	10	that	that	IN
cord-292688-w4zvfkyl	201	11	PLD	PLD	NNP
cord-292688-w4zvfkyl	201	12	does	do	VBZ
cord-292688-w4zvfkyl	201	13	not	not	RB
cord-292688-w4zvfkyl	201	14	play	play	VB
cord-292688-w4zvfkyl	201	15	a	a	DT
cord-292688-w4zvfkyl	201	16	role	role	NN
cord-292688-w4zvfkyl	201	17	in	in	IN
cord-292688-w4zvfkyl	201	18	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	201	19	recruitment	recruitment	NN
cord-292688-w4zvfkyl	201	20	[	[	-LRB-
cord-292688-w4zvfkyl	201	21	84	84	CD
cord-292688-w4zvfkyl	201	22	]	]	-RRB-
cord-292688-w4zvfkyl	201	23	to	to	IN
cord-292688-w4zvfkyl	201	24	TGN	TGN	NNP
cord-292688-w4zvfkyl	201	25	membranes	membrane	NNS
cord-292688-w4zvfkyl	201	26	,	,	,
cord-292688-w4zvfkyl	201	27	it	-PRON-	PRP
cord-292688-w4zvfkyl	201	28	would	would	MD
cord-292688-w4zvfkyl	201	29	thus	thus	RB
cord-292688-w4zvfkyl	201	30	seem	seem	VB
cord-292688-w4zvfkyl	201	31	most	most	RBS
cord-292688-w4zvfkyl	201	32	likely	likely	JJ
cord-292688-w4zvfkyl	201	33	that	that	DT
cord-292688-w4zvfkyl	201	34	ARF	ARF	NNP
cord-292688-w4zvfkyl	201	35	and	and	CC
cord-292688-w4zvfkyl	201	36	PLD	PLD	NNP
cord-292688-w4zvfkyl	201	37	are	be	VBP
cord-292688-w4zvfkyl	201	38	functioning	function	VBG
cord-292688-w4zvfkyl	201	39	to	to	TO
cord-292688-w4zvfkyl	201	40	promote	promote	VB
cord-292688-w4zvfkyl	201	41	budding	bud	VBG
cord-292688-w4zvfkyl	201	42	from	from	IN
cord-292688-w4zvfkyl	201	43	the	the	DT
cord-292688-w4zvfkyl	201	44	TGN	TGN	NNP
cord-292688-w4zvfkyl	201	45	via	via	IN
cord-292688-w4zvfkyl	201	46	a	a	DT
cord-292688-w4zvfkyl	201	47	signalling	signal	VBG
cord-292688-w4zvfkyl	201	48	cascade	cascade	NN
cord-292688-w4zvfkyl	201	49	.	.	.
cord-292688-w4zvfkyl	202	1	Consistent	consistent	JJ
cord-292688-w4zvfkyl	202	2	with	with	IN
cord-292688-w4zvfkyl	202	3	this	this	DT
cord-292688-w4zvfkyl	202	4	scenario	scenario	NN
cord-292688-w4zvfkyl	202	5	[	[	-LRB-
cord-292688-w4zvfkyl	202	6	73	73	CD
cord-292688-w4zvfkyl	202	7	]	]	-RRB-
cord-292688-w4zvfkyl	202	8	Shields	Shields	NNPS
cord-292688-w4zvfkyl	202	9	and	and	CC
cord-292688-w4zvfkyl	202	10	colleagues	colleague	NNS
cord-292688-w4zvfkyl	202	11	had	have	VBD
cord-292688-w4zvfkyl	202	12	previously	previously	RB
cord-292688-w4zvfkyl	202	13	shown	show	VBN
cord-292688-w4zvfkyl	202	14	that	that	IN
cord-292688-w4zvfkyl	202	15	PKC	PKC	NNP
cord-292688-w4zvfkyl	202	16	can	can	MD
cord-292688-w4zvfkyl	202	17	stimulate	stimulate	VB
cord-292688-w4zvfkyl	202	18	budding	bud	VBG
cord-292688-w4zvfkyl	202	19	,	,	,
cord-292688-w4zvfkyl	202	20	and	and	CC
cord-292688-w4zvfkyl	202	21	suggest	suggest	VBP
cord-292688-w4zvfkyl	202	22	that	that	IN
cord-292688-w4zvfkyl	202	23	PA	PA	NNP
cord-292688-w4zvfkyl	202	24	could	could	MD
cord-292688-w4zvfkyl	202	25	function	function	VB
cord-292688-w4zvfkyl	202	26	as	as	IN
cord-292688-w4zvfkyl	202	27	a	a	DT
cord-292688-w4zvfkyl	202	28	second	second	JJ
cord-292688-w4zvfkyl	202	29	messenger	messenger	NN
cord-292688-w4zvfkyl	202	30	to	to	TO
cord-292688-w4zvfkyl	202	31	trigger	trigger	VB
cord-292688-w4zvfkyl	202	32	intracellular	intracellular	JJ
cord-292688-w4zvfkyl	202	33	signalling	signal	VBG
cord-292688-w4zvfkyl	202	34	events	event	NNS
cord-292688-w4zvfkyl	202	35	such	such	JJ
cord-292688-w4zvfkyl	202	36	as	as	IN
cord-292688-w4zvfkyl	202	37	activation	activation	NN
cord-292688-w4zvfkyl	202	38	of	of	IN
cord-292688-w4zvfkyl	202	39	PKC	PKC	NNP
cord-292688-w4zvfkyl	202	40	.	.	.
cord-292688-w4zvfkyl	203	1	Further	further	JJ
cord-292688-w4zvfkyl	203	2	exciting	exciting	JJ
cord-292688-w4zvfkyl	203	3	results	result	NNS
cord-292688-w4zvfkyl	203	4	have	have	VBP
cord-292688-w4zvfkyl	203	5	been	be	VBN
cord-292688-w4zvfkyl	203	6	obtained	obtain	VBN
cord-292688-w4zvfkyl	203	7	with	with	IN
cord-292688-w4zvfkyl	203	8	regard	regard	NN
cord-292688-w4zvfkyl	203	9	to	to	IN
cord-292688-w4zvfkyl	203	10	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	203	11	proteins	protein	NNS
cord-292688-w4zvfkyl	203	12	required	require	VBN
cord-292688-w4zvfkyl	203	13	for	for	IN
cord-292688-w4zvfkyl	203	14	vesicle	vesicle	NN
cord-292688-w4zvfkyl	203	15	formation	formation	NN
cord-292688-w4zvfkyl	203	16	from	from	IN
cord-292688-w4zvfkyl	203	17	the	the	DT
cord-292688-w4zvfkyl	203	18	TGN	TGN	NNP
cord-292688-w4zvfkyl	203	19	.	.	.
cord-292688-w4zvfkyl	204	1	A	a	DT
cord-292688-w4zvfkyl	204	2	phosphatidylinositol	phosphatidylinositol	JJ
cord-292688-w4zvfkyl	204	3	transfer	transfer	NN
cord-292688-w4zvfkyl	204	4	protein	protein	NN
cord-292688-w4zvfkyl	204	5	(	(	-LRB-
cord-292688-w4zvfkyl	204	6	PITP	PITP	NNP
cord-292688-w4zvfkyl	204	7	)	)	-RRB-
cord-292688-w4zvfkyl	204	8	has	have	VBZ
cord-292688-w4zvfkyl	204	9	been	be	VBN
cord-292688-w4zvfkyl	204	10	implicated	implicate	VBN
cord-292688-w4zvfkyl	204	11	in	in	IN
cord-292688-w4zvfkyl	204	12	the	the	DT
cord-292688-w4zvfkyl	204	13	formation	formation	NN
cord-292688-w4zvfkyl	204	14	of	of	IN
cord-292688-w4zvfkyl	204	15	both	both	CC
cord-292688-w4zvfkyl	204	16	regulated	regulated	JJ
cord-292688-w4zvfkyl	204	17	and	and	CC
cord-292688-w4zvfkyl	204	18	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	204	19	secretory	secretory	JJ
cord-292688-w4zvfkyl	204	20	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	204	21	[	[	-LRB-
cord-292688-w4zvfkyl	204	22	90	90	CD
cord-292688-w4zvfkyl	204	23	]	]	-RRB-
cord-292688-w4zvfkyl	204	24	.	.	.
cord-292688-w4zvfkyl	205	1	The	the	DT
cord-292688-w4zvfkyl	205	2	mammalian	mammalian	JJ
cord-292688-w4zvfkyl	205	3	PITP	PITP	NNP
cord-292688-w4zvfkyl	205	4	activity	activity	NN
cord-292688-w4zvfkyl	205	5	can	can	MD
cord-292688-w4zvfkyl	205	6	be	be	VB
cord-292688-w4zvfkyl	205	7	substituted	substitute	VBN
cord-292688-w4zvfkyl	205	8	for	for	IN
cord-292688-w4zvfkyl	205	9	by	by	IN
cord-292688-w4zvfkyl	205	10	Sec14p	Sec14p	NNP
cord-292688-w4zvfkyl	205	11	,	,	,
cord-292688-w4zvfkyl	205	12	a	a	DT
cord-292688-w4zvfkyl	205	13	yeast	yeast	NN
cord-292688-w4zvfkyl	205	14	protein	protein	NN
cord-292688-w4zvfkyl	205	15	from	from	IN
cord-292688-w4zvfkyl	205	16	Saccharomyces	Saccharomyces	NNP
cord-292688-w4zvfkyl	205	17	cerevisiae	cerevisiae	NNS
cord-292688-w4zvfkyl	205	18	(	(	-LRB-
cord-292688-w4zvfkyl	205	19	which	which	WDT
cord-292688-w4zvfkyl	205	20	is	be	VBZ
cord-292688-w4zvfkyl	205	21	,	,	,
cord-292688-w4zvfkyl	205	22	however	however	RB
cord-292688-w4zvfkyl	205	23	,	,	,
cord-292688-w4zvfkyl	205	24	not	not	RB
cord-292688-w4zvfkyl	205	25	homologous	homologous	JJ
cord-292688-w4zvfkyl	205	26	to	to	IN
cord-292688-w4zvfkyl	205	27	the	the	DT
cord-292688-w4zvfkyl	205	28	mammalian	mammalian	JJ
cord-292688-w4zvfkyl	205	29	PITP	PITP	NNP
cord-292688-w4zvfkyl	205	30	)	)	-RRB-
cord-292688-w4zvfkyl	205	31	that	that	WDT
cord-292688-w4zvfkyl	205	32	is	be	VBZ
cord-292688-w4zvfkyl	205	33	required	require	VBN
cord-292688-w4zvfkyl	205	34	for	for	IN
cord-292688-w4zvfkyl	205	35	normal	normal	JJ
cord-292688-w4zvfkyl	205	36	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	205	37	function	function	NN
cord-292688-w4zvfkyl	205	38	and	and	CC
cord-292688-w4zvfkyl	205	39	shares	share	NNS
cord-292688-w4zvfkyl	205	40	with	with	IN
cord-292688-w4zvfkyl	205	41	PITP	PITP	NNP
cord-292688-w4zvfkyl	205	42	the	the	DT
cord-292688-w4zvfkyl	205	43	ability	ability	NN
cord-292688-w4zvfkyl	205	44	to	to	TO
cord-292688-w4zvfkyl	205	45	exchange	exchange	VB
cord-292688-w4zvfkyl	205	46	phosphatidylinositol	phosphatidylinositol	NN
cord-292688-w4zvfkyl	205	47	for	for	IN
cord-292688-w4zvfkyl	205	48	phosphatidylcholine	phosphatidylcholine	NN
cord-292688-w4zvfkyl	205	49	(	(	-LRB-
cord-292688-w4zvfkyl	205	50	[	[	-LRB-
cord-292688-w4zvfkyl	205	51	91	91	CD
cord-292688-w4zvfkyl	205	52	]	]	-RRB-
cord-292688-w4zvfkyl	205	53	;	;	:
cord-292688-w4zvfkyl	205	54	see	see	VB
cord-292688-w4zvfkyl	205	55	also	also	RB
cord-292688-w4zvfkyl	205	56	contribution	contribution	VB
cord-292688-w4zvfkyl	205	57	in	in	IN
cord-292688-w4zvfkyl	205	58	this	this	DT
cord-292688-w4zvfkyl	205	59	issue	issue	NN
cord-292688-w4zvfkyl	205	60	by	by	IN
cord-292688-w4zvfkyl	205	61	Bankaitis	Bankaitis	NNP
cord-292688-w4zvfkyl	205	62	)	)	-RRB-
cord-292688-w4zvfkyl	205	63	.	.	.
cord-292688-w4zvfkyl	206	1	Additional	additional	JJ
cord-292688-w4zvfkyl	206	2	evidence	evidence	NN
cord-292688-w4zvfkyl	206	3	recently	recently	RB
cord-292688-w4zvfkyl	206	4	published	publish	VBD
cord-292688-w4zvfkyl	206	5	related	relate	VBN
cord-292688-w4zvfkyl	206	6	to	to	IN
cord-292688-w4zvfkyl	206	7	the	the	DT
cord-292688-w4zvfkyl	206	8	function	function	NN
cord-292688-w4zvfkyl	206	9	of	of	IN
cord-292688-w4zvfkyl	206	10	Sec14p	Sec14p	NNP
cord-292688-w4zvfkyl	206	11	,	,	,
cord-292688-w4zvfkyl	206	12	obtained	obtain	VBN
cord-292688-w4zvfkyl	206	13	from	from	IN
cord-292688-w4zvfkyl	206	14	the	the	DT
cord-292688-w4zvfkyl	206	15	study	study	NN
cord-292688-w4zvfkyl	206	16	of	of	IN
cord-292688-w4zvfkyl	206	17	Sac1p	Sac1p	NNP
cord-292688-w4zvfkyl	206	18	,	,	,
cord-292688-w4zvfkyl	206	19	a	a	DT
cord-292688-w4zvfkyl	206	20	sec14-bypass	sec14-bypass	NN
cord-292688-w4zvfkyl	206	21	suppressor	suppressor	NN
cord-292688-w4zvfkyl	206	22	[	[	-LRB-
cord-292688-w4zvfkyl	206	23	92	92	CD
cord-292688-w4zvfkyl	206	24	]	]	-RRB-
cord-292688-w4zvfkyl	206	25	would	would	MD
cord-292688-w4zvfkyl	206	26	suggest	suggest	VB
cord-292688-w4zvfkyl	206	27	that	that	IN
cord-292688-w4zvfkyl	206	28	PITP	PITP	NNP
cord-292688-w4zvfkyl	206	29	can	can	MD
cord-292688-w4zvfkyl	206	30	also	also	RB
cord-292688-w4zvfkyl	206	31	function	function	VB
cord-292688-w4zvfkyl	206	32	to	to	TO
cord-292688-w4zvfkyl	206	33	cause	cause	VB
cord-292688-w4zvfkyl	206	34	a	a	DT
cord-292688-w4zvfkyl	206	35	local	local	JJ
cord-292688-w4zvfkyl	206	36	production	production	NN
cord-292688-w4zvfkyl	206	37	of	of	IN
cord-292688-w4zvfkyl	206	38	diacylglycerol	diacylglycerol	NN
cord-292688-w4zvfkyl	206	39	which	which	WDT
cord-292688-w4zvfkyl	206	40	may	may	MD
cord-292688-w4zvfkyl	206	41	be	be	VB
cord-292688-w4zvfkyl	206	42	involved	involve	VBN
cord-292688-w4zvfkyl	206	43	in	in	IN
cord-292688-w4zvfkyl	206	44	coat	coat	NN
cord-292688-w4zvfkyl	206	45	recruitment	recruitment	NN
cord-292688-w4zvfkyl	206	46	in	in	IN
cord-292688-w4zvfkyl	206	47	much	much	RB
cord-292688-w4zvfkyl	206	48	the	the	DT
cord-292688-w4zvfkyl	206	49	same	same	JJ
cord-292688-w4zvfkyl	206	50	way	way	NN
cord-292688-w4zvfkyl	206	51	the	the	DT
cord-292688-w4zvfkyl	206	52	PA	PA	NNP
cord-292688-w4zvfkyl	206	53	has	have	VBZ
cord-292688-w4zvfkyl	206	54	been	be	VBN
cord-292688-w4zvfkyl	206	55	postulated	postulate	VBN
cord-292688-w4zvfkyl	206	56	to	to	TO
cord-292688-w4zvfkyl	206	57	be	be	VB
cord-292688-w4zvfkyl	206	58	involved	involve	VBN
cord-292688-w4zvfkyl	206	59	in	in	IN
cord-292688-w4zvfkyl	206	60	ARF	ARF	NNP
cord-292688-w4zvfkyl	206	61	and	and	CC
cord-292688-w4zvfkyl	206	62	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	206	63	recruitment	recruitment	NN
cord-292688-w4zvfkyl	206	64	(	(	-LRB-
cord-292688-w4zvfkyl	206	65	see	see	VB
cord-292688-w4zvfkyl	206	66	review	review	VB
cord-292688-w4zvfkyl	206	67	[	[	-LRB-
cord-292688-w4zvfkyl	206	68	93	93	CD
cord-292688-w4zvfkyl	206	69	]	]	-RRB-
cord-292688-w4zvfkyl	206	70	)	)	-RRB-
cord-292688-w4zvfkyl	206	71	.	.	.
cord-292688-w4zvfkyl	207	1	PtdIns	PtdIns	NNP
cord-292688-w4zvfkyl	207	2	is	be	VBZ
cord-292688-w4zvfkyl	207	3	also	also	RB
cord-292688-w4zvfkyl	207	4	the	the	DT
cord-292688-w4zvfkyl	207	5	substrate	substrate	NN
cord-292688-w4zvfkyl	207	6	for	for	IN
cord-292688-w4zvfkyl	207	7	the	the	DT
cord-292688-w4zvfkyl	207	8	yeast	yeast	NN
cord-292688-w4zvfkyl	207	9	kinase	kinase	NN
cord-292688-w4zvfkyl	207	10	Vps34	Vps34	NNP
cord-292688-w4zvfkyl	207	11	which	which	WDT
cord-292688-w4zvfkyl	207	12	has	have	VBZ
cord-292688-w4zvfkyl	207	13	PI	pi	NN
cord-292688-w4zvfkyl	207	14	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	207	15	activity	activity	NN
cord-292688-w4zvfkyl	207	16	[	[	-LRB-
cord-292688-w4zvfkyl	207	17	94	94	CD
cord-292688-w4zvfkyl	207	18	]	]	-RRB-
cord-292688-w4zvfkyl	207	19	.	.	.
cord-292688-w4zvfkyl	208	1	The	the	DT
cord-292688-w4zvfkyl	208	2	synthesis	synthesis	NN
cord-292688-w4zvfkyl	208	3	of	of	IN
cord-292688-w4zvfkyl	208	4	PdtIns(3)P	PdtIns(3)P	NNP
cord-292688-w4zvfkyl	208	5	by	by	IN
cord-292688-w4zvfkyl	208	6	Vps34	Vps34	NNP
cord-292688-w4zvfkyl	208	7	has	have	VBZ
cord-292688-w4zvfkyl	208	8	been	be	VBN
cord-292688-w4zvfkyl	208	9	implicated	implicate	VBN
cord-292688-w4zvfkyl	208	10	in	in	IN
cord-292688-w4zvfkyl	208	11	the	the	DT
cord-292688-w4zvfkyl	208	12	transport	transport	NN
cord-292688-w4zvfkyl	208	13	from	from	IN
cord-292688-w4zvfkyl	208	14	the	the	DT
cord-292688-w4zvfkyl	208	15	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	208	16	to	to	IN
cord-292688-w4zvfkyl	208	17	the	the	DT
cord-292688-w4zvfkyl	208	18	vacuole	vacuole	NN
cord-292688-w4zvfkyl	208	19	in	in	IN
cord-292688-w4zvfkyl	208	20	yeast	yeast	NN
cord-292688-w4zvfkyl	208	21	and	and	CC
cord-292688-w4zvfkyl	208	22	it	-PRON-	PRP
cord-292688-w4zvfkyl	208	23	has	have	VBZ
cord-292688-w4zvfkyl	208	24	been	be	VBN
cord-292688-w4zvfkyl	208	25	suggested	suggest	VBN
cord-292688-w4zvfkyl	208	26	that	that	IN
cord-292688-w4zvfkyl	208	27	Vps34	Vps34	NNP
cord-292688-w4zvfkyl	208	28	activity	activity	NN
cord-292688-w4zvfkyl	208	29	is	be	VBZ
cord-292688-w4zvfkyl	208	30	required	require	VBN
cord-292688-w4zvfkyl	208	31	for	for	IN
cord-292688-w4zvfkyl	208	32	the	the	DT
cord-292688-w4zvfkyl	208	33	formation	formation	NN
cord-292688-w4zvfkyl	208	34	of	of	IN
cord-292688-w4zvfkyl	208	35	a	a	DT
cord-292688-w4zvfkyl	208	36	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	208	37	vesicle	vesicle	NN
cord-292688-w4zvfkyl	208	38	type	type	NN
cord-292688-w4zvfkyl	208	39	from	from	IN
cord-292688-w4zvfkyl	208	40	the	the	DT
cord-292688-w4zvfkyl	208	41	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	208	42	[	[	-LRB-
cord-292688-w4zvfkyl	208	43	95	95	CD
cord-292688-w4zvfkyl	208	44	]	]	-RRB-
cord-292688-w4zvfkyl	208	45	.	.	.
cord-292688-w4zvfkyl	209	1	A	a	DT
cord-292688-w4zvfkyl	209	2	wortmannin	wortmannin	NN
cord-292688-w4zvfkyl	209	3	-	-	HYPH
cord-292688-w4zvfkyl	209	4	sensitive	sensitive	JJ
cord-292688-w4zvfkyl	209	5	PI	pi	NN
cord-292688-w4zvfkyl	209	6	3kinase	3kinase	CD
cord-292688-w4zvfkyl	209	7	activity	activity	NN
cord-292688-w4zvfkyl	209	8	is	be	VBZ
cord-292688-w4zvfkyl	209	9	also	also	RB
cord-292688-w4zvfkyl	209	10	required	require	VBN
cord-292688-w4zvfkyl	209	11	for	for	IN
cord-292688-w4zvfkyl	209	12	the	the	DT
cord-292688-w4zvfkyl	209	13	sorting	sorting	NN
cord-292688-w4zvfkyl	209	14	of	of	IN
cord-292688-w4zvfkyl	209	15	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	209	16	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	209	17	from	from	IN
cord-292688-w4zvfkyl	209	18	the	the	DT
cord-292688-w4zvfkyl	209	19	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	209	20	to	to	IN
cord-292688-w4zvfkyl	209	21	the	the	DT
cord-292688-w4zvfkyl	209	22	endosome	endosome	NN
cord-292688-w4zvfkyl	209	23	in	in	IN
cord-292688-w4zvfkyl	209	24	mammalian	mammalian	JJ
cord-292688-w4zvfkyl	209	25	cells	cell	NNS
cord-292688-w4zvfkyl	209	26	(	(	-LRB-
cord-292688-w4zvfkyl	209	27	see	see	VB
cord-292688-w4zvfkyl	209	28	[	[	-LRB-
cord-292688-w4zvfkyl	209	29	96	96	CD
cord-292688-w4zvfkyl	209	30	]	]	-RRB-
cord-292688-w4zvfkyl	209	31	for	for	IN
cord-292688-w4zvfkyl	209	32	review	review	NN
cord-292688-w4zvfkyl	209	33	)	)	-RRB-
cord-292688-w4zvfkyl	209	34	.	.	.
cord-292688-w4zvfkyl	210	1	In	in	IN
cord-292688-w4zvfkyl	210	2	addition	addition	NN
cord-292688-w4zvfkyl	210	3	,	,	,
cord-292688-w4zvfkyl	210	4	a	a	DT
cord-292688-w4zvfkyl	210	5	recent	recent	JJ
cord-292688-w4zvfkyl	210	6	report	report	NN
cord-292688-w4zvfkyl	210	7	has	have	VBZ
cord-292688-w4zvfkyl	210	8	shown	show	VBN
cord-292688-w4zvfkyl	210	9	that	that	IN
cord-292688-w4zvfkyl	210	10	a	a	DT
cord-292688-w4zvfkyl	210	11	PI	pi	NN
cord-292688-w4zvfkyl	210	12	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	210	13	activity	activity	NN
cord-292688-w4zvfkyl	210	14	is	be	VBZ
cord-292688-w4zvfkyl	210	15	required	require	VBN
cord-292688-w4zvfkyl	210	16	for	for	IN
cord-292688-w4zvfkyl	210	17	formation	formation	NN
cord-292688-w4zvfkyl	210	18	of	of	IN
cord-292688-w4zvfkyl	210	19	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	210	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	210	21	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	210	22	from	from	IN
cord-292688-w4zvfkyl	210	23	isolated	isolate	VBN
cord-292688-w4zvfkyl	210	24	rat	rat	NN
cord-292688-w4zvfkyl	210	25	liver	liver	NN
cord-292688-w4zvfkyl	210	26	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	210	27	membranes	membrane	NNS
cord-292688-w4zvfkyl	210	28	[	[	-LRB-
cord-292688-w4zvfkyl	210	29	97	97	CD
cord-292688-w4zvfkyl	210	30	]	]	-RRB-
cord-292688-w4zvfkyl	210	31	.	.	.
cord-292688-w4zvfkyl	211	1	Interestingly	interestingly	RB
cord-292688-w4zvfkyl	211	2	,	,	,
cord-292688-w4zvfkyl	211	3	this	this	DT
cord-292688-w4zvfkyl	211	4	PI	PI	NNP
cord-292688-w4zvfkyl	211	5	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	211	6	regulatory	regulatory	JJ
cord-292688-w4zvfkyl	211	7	subunit	subunit	NN
cord-292688-w4zvfkyl	211	8	associates	associate	NNS
cord-292688-w4zvfkyl	211	9	with	with	IN
cord-292688-w4zvfkyl	211	10	the	the	DT
cord-292688-w4zvfkyl	211	11	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	211	12	domain	domain	NN
cord-292688-w4zvfkyl	211	13	of	of	IN
cord-292688-w4zvfkyl	211	14	a	a	DT
cord-292688-w4zvfkyl	211	15	TGN	TGN	NNP
cord-292688-w4zvfkyl	211	16	-	-	HYPH
cord-292688-w4zvfkyl	211	17	resident	resident	NN
cord-292688-w4zvfkyl	211	18	protein	protein	NN
cord-292688-w4zvfkyl	211	19	TGN38	TGN38	VBZ
cord-292688-w4zvfkyl	211	20	in	in	IN
cord-292688-w4zvfkyl	211	21	a	a	DT
cord-292688-w4zvfkyl	211	22	complex	complex	NN
cord-292688-w4zvfkyl	211	23	with	with	IN
cord-292688-w4zvfkyl	211	24	a	a	DT
cord-292688-w4zvfkyl	211	25	small	small	JJ
cord-292688-w4zvfkyl	211	26	molecular	molecular	JJ
cord-292688-w4zvfkyl	211	27	weight	weight	NN
cord-292688-w4zvfkyl	212	1	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	212	2	,	,	,
cord-292688-w4zvfkyl	212	3	previously	previously	RB
cord-292688-w4zvfkyl	212	4	identi¢ed	identi¢ed	.
cord-292688-w4zvfkyl	212	5	as	as	IN
cord-292688-w4zvfkyl	212	6	rab6	rab6	NNP
cord-292688-w4zvfkyl	212	7	[	[	-LRB-
cord-292688-w4zvfkyl	212	8	67	67	CD
cord-292688-w4zvfkyl	212	9	]	]	-RRB-
cord-292688-w4zvfkyl	212	10	.	.	.
cord-292688-w4zvfkyl	213	1	The	the	DT
cord-292688-w4zvfkyl	213	2	authors	author	NNS
cord-292688-w4zvfkyl	213	3	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	213	4	is	be	VBZ
cord-292688-w4zvfkyl	213	5	that	that	IN
cord-292688-w4zvfkyl	213	6	the	the	DT
cord-292688-w4zvfkyl	213	7	activity	activity	NN
cord-292688-w4zvfkyl	213	8	of	of	IN
cord-292688-w4zvfkyl	213	9	the	the	DT
cord-292688-w4zvfkyl	213	10	PI	PI	NNP
cord-292688-w4zvfkyl	213	11	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	213	12	is	be	VBZ
cord-292688-w4zvfkyl	213	13	stimulated	stimulate	VBN
cord-292688-w4zvfkyl	213	14	by	by	IN
cord-292688-w4zvfkyl	213	15	the	the	DT
cord-292688-w4zvfkyl	213	16	activation	activation	NN
cord-292688-w4zvfkyl	213	17	of	of	IN
cord-292688-w4zvfkyl	213	18	the	the	DT
cord-292688-w4zvfkyl	213	19	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	213	20	[	[	-LRB-
cord-292688-w4zvfkyl	213	21	97	97	CD
cord-292688-w4zvfkyl	213	22	]	]	-RRB-
cord-292688-w4zvfkyl	213	23	.	.	.
cord-292688-w4zvfkyl	214	1	So	so	RB
cord-292688-w4zvfkyl	214	2	far	far	RB
cord-292688-w4zvfkyl	214	3	there	there	EX
cord-292688-w4zvfkyl	214	4	has	have	VBZ
cord-292688-w4zvfkyl	214	5	been	be	VBN
cord-292688-w4zvfkyl	214	6	no	no	DT
cord-292688-w4zvfkyl	214	7	report	report	NN
cord-292688-w4zvfkyl	214	8	implicating	implicate	VBG
cord-292688-w4zvfkyl	214	9	a	a	DT
cord-292688-w4zvfkyl	214	10	PI	PI	NNP
cord-292688-w4zvfkyl	214	11	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	214	12	in	in	IN
cord-292688-w4zvfkyl	214	13	the	the	DT
cord-292688-w4zvfkyl	214	14	budding	budding	NN
cord-292688-w4zvfkyl	214	15	of	of	IN
cord-292688-w4zvfkyl	214	16	regulated	regulated	JJ
cord-292688-w4zvfkyl	214	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	214	18	granules	granule	NNS
cord-292688-w4zvfkyl	214	19	.	.	.
cord-292688-w4zvfkyl	215	1	In	in	IN
cord-292688-w4zvfkyl	215	2	fact	fact	NN
cord-292688-w4zvfkyl	215	3	,	,	,
cord-292688-w4zvfkyl	215	4	incubation	incubation	NN
cord-292688-w4zvfkyl	215	5	of	of	IN
cord-292688-w4zvfkyl	215	6	PC12	pc12	JJ
cord-292688-w4zvfkyl	215	7	cells	cell	NNS
cord-292688-w4zvfkyl	215	8	with	with	IN
cord-292688-w4zvfkyl	215	9	wortmannin	wortmannin	NN
cord-292688-w4zvfkyl	215	10	had	have	VBD
cord-292688-w4zvfkyl	215	11	no	no	DT
cord-292688-w4zvfkyl	215	12	e¡ect	e¡ect	XX
cord-292688-w4zvfkyl	215	13	on	on	IN
cord-292688-w4zvfkyl	215	14	either	either	DT
cord-292688-w4zvfkyl	215	15	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	215	16	or	or	CC
cord-292688-w4zvfkyl	215	17	regulated	regulate	VBN
cord-292688-w4zvfkyl	215	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	215	19	vesicle	vesicle	NN
cord-292688-w4zvfkyl	215	20	formation	formation	NN
cord-292688-w4zvfkyl	215	21	,	,	,
cord-292688-w4zvfkyl	215	22	transport	transport	NN
cord-292688-w4zvfkyl	215	23	or	or	CC
cord-292688-w4zvfkyl	215	24	exocytosis	exocytosis	NN
cord-292688-w4zvfkyl	215	25	of	of	IN
cord-292688-w4zvfkyl	215	26	secretory	secretory	JJ
cord-292688-w4zvfkyl	215	27	proteins	protein	NNS
cord-292688-w4zvfkyl	215	28	(	(	-LRB-
cord-292688-w4zvfkyl	215	29	S.	S.	NNP
cord-292688-w4zvfkyl	215	30	Urbë	Urbë	NNP
cord-292688-w4zvfkyl	215	31	and	and	CC
cord-292688-w4zvfkyl	215	32	S.A.	S.A.	NNP
cord-292688-w4zvfkyl	215	33	Tooze	Tooze	NNP
cord-292688-w4zvfkyl	215	34	,	,	,
cord-292688-w4zvfkyl	215	35	unpublished	unpublished	JJ
cord-292688-w4zvfkyl	215	36	observations	observation	NNS
cord-292688-w4zvfkyl	215	37	)	)	-RRB-
cord-292688-w4zvfkyl	215	38	.	.	.
cord-292688-w4zvfkyl	216	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	216	2	maybe	maybe	RB
cord-292688-w4zvfkyl	216	3	that	that	IN
cord-292688-w4zvfkyl	216	4	the	the	DT
cord-292688-w4zvfkyl	216	5	activation	activation	NN
cord-292688-w4zvfkyl	216	6	of	of	IN
cord-292688-w4zvfkyl	216	7	the	the	DT
cord-292688-w4zvfkyl	216	8	PI	PI	NNP
cord-292688-w4zvfkyl	216	9	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	216	10	is	be	VBZ
cord-292688-w4zvfkyl	216	11	dependent	dependent	JJ
cord-292688-w4zvfkyl	216	12	upon	upon	IN
cord-292688-w4zvfkyl	216	13	the	the	DT
cord-292688-w4zvfkyl	216	14	presence	presence	NN
cord-292688-w4zvfkyl	216	15	of	of	IN
cord-292688-w4zvfkyl	216	16	particular	particular	JJ
cord-292688-w4zvfkyl	216	17	receptors	receptor	NNS
cord-292688-w4zvfkyl	216	18	in	in	IN
cord-292688-w4zvfkyl	216	19	the	the	DT
cord-292688-w4zvfkyl	216	20	forming	form	VBG
cord-292688-w4zvfkyl	216	21	bud	bud	NN
cord-292688-w4zvfkyl	216	22	,	,	,
cord-292688-w4zvfkyl	216	23	for	for	IN
cord-292688-w4zvfkyl	216	24	example	example	NN
cord-292688-w4zvfkyl	216	25	,	,	,
cord-292688-w4zvfkyl	216	26	the	the	DT
cord-292688-w4zvfkyl	216	27	presence	presence	NN
cord-292688-w4zvfkyl	216	28	of	of	IN
cord-292688-w4zvfkyl	216	29	TGN38	tgn38	PRP
cord-292688-w4zvfkyl	216	30	.	.	.
cord-292688-w4zvfkyl	217	1	Data	datum	NNS
cord-292688-w4zvfkyl	217	2	from	from	IN
cord-292688-w4zvfkyl	217	3	experiments	experiment	NNS
cord-292688-w4zvfkyl	217	4	performed	perform	VBN
cord-292688-w4zvfkyl	217	5	to	to	TO
cord-292688-w4zvfkyl	217	6	examine	examine	VB
cord-292688-w4zvfkyl	217	7	the	the	DT
cord-292688-w4zvfkyl	217	8	composition	composition	NN
cord-292688-w4zvfkyl	217	9	of	of	IN
cord-292688-w4zvfkyl	217	10	the	the	DT
cord-292688-w4zvfkyl	217	11	nascent	nascent	JJ
cord-292688-w4zvfkyl	217	12	ISG	ISG	NNP
cord-292688-w4zvfkyl	217	13	demonstrates	demonstrate	VBZ
cord-292688-w4zvfkyl	217	14	that	that	IN
cord-292688-w4zvfkyl	217	15	there	there	EX
cord-292688-w4zvfkyl	217	16	is	be	VBZ
cord-292688-w4zvfkyl	217	17	no	no	DT
cord-292688-w4zvfkyl	217	18	TGN38	TGN38	NNP
cord-292688-w4zvfkyl	217	19	present	present	JJ
cord-292688-w4zvfkyl	217	20	in	in	IN
cord-292688-w4zvfkyl	217	21	ISGs	isg	NNS
cord-292688-w4zvfkyl	217	22	[	[	-LRB-
cord-292688-w4zvfkyl	217	23	63	63	CD
cord-292688-w4zvfkyl	217	24	]	]	-RRB-
cord-292688-w4zvfkyl	217	25	.	.	.
cord-292688-w4zvfkyl	218	1	With	with	IN
cord-292688-w4zvfkyl	218	2	regard	regard	NN
cord-292688-w4zvfkyl	218	3	to	to	IN
cord-292688-w4zvfkyl	218	4	the	the	DT
cord-292688-w4zvfkyl	218	5	role	role	NN
cord-292688-w4zvfkyl	218	6	of	of	IN
cord-292688-w4zvfkyl	218	7	PtdIns	PtdIns	NNP
cord-292688-w4zvfkyl	218	8	-	-	HYPH
cord-292688-w4zvfkyl	218	9	metabolites	metabolite	NNS
cord-292688-w4zvfkyl	218	10	in	in	IN
cord-292688-w4zvfkyl	218	11	vesicle	vesicle	NN
cord-292688-w4zvfkyl	218	12	-	-	HYPH
cord-292688-w4zvfkyl	218	13	formation	formation	NN
cord-292688-w4zvfkyl	218	14	,	,	,
cord-292688-w4zvfkyl	218	15	it	-PRON-	PRP
cord-292688-w4zvfkyl	218	16	is	be	VBZ
cord-292688-w4zvfkyl	218	17	of	of	IN
cord-292688-w4zvfkyl	218	18	interest	interest	NN
cord-292688-w4zvfkyl	218	19	that	that	WDT
cord-292688-w4zvfkyl	218	20	a	a	DT
cord-292688-w4zvfkyl	218	21	105	105	CD
cord-292688-w4zvfkyl	218	22	kDa	kDa	NNP
cord-292688-w4zvfkyl	218	23	protein	protein	NN
cord-292688-w4zvfkyl	218	24	,	,	,
cord-292688-w4zvfkyl	218	25	oculocerebrorenal	oculocerebrorenal	JJ
cord-292688-w4zvfkyl	218	26	syndrome	syndrome	NN
cord-292688-w4zvfkyl	218	27	of	of	IN
cord-292688-w4zvfkyl	218	28	Lowe	Lowe	NNP
cord-292688-w4zvfkyl	218	29	(	(	-LRB-
cord-292688-w4zvfkyl	218	30	OCRL	OCRL	NNP
cord-292688-w4zvfkyl	218	31	)	)	-RRB-
cord-292688-w4zvfkyl	218	32	[	[	-LRB-
cord-292688-w4zvfkyl	218	33	98	98	CD
cord-292688-w4zvfkyl	218	34	]	]	-RRB-
cord-292688-w4zvfkyl	218	35	,	,	,
cord-292688-w4zvfkyl	218	36	belonging	belong	VBG
cord-292688-w4zvfkyl	218	37	to	to	IN
cord-292688-w4zvfkyl	218	38	the	the	DT
cord-292688-w4zvfkyl	218	39	inositol	inositol	NN
cord-292688-w4zvfkyl	218	40	(	(	-LRB-
cord-292688-w4zvfkyl	218	41	Ins	Ins	NNP
cord-292688-w4zvfkyl	218	42	)	)	-RRB-
cord-292688-w4zvfkyl	218	43	5-phosphatase	5-phosphatase	CD
cord-292688-w4zvfkyl	218	44	family	family	NN
cord-292688-w4zvfkyl	218	45	has	have	VBZ
cord-292688-w4zvfkyl	218	46	recently	recently	RB
cord-292688-w4zvfkyl	218	47	been	be	VBN
cord-292688-w4zvfkyl	218	48	localized	localize	VBN
cord-292688-w4zvfkyl	218	49	to	to	IN
cord-292688-w4zvfkyl	218	50	the	the	DT
cord-292688-w4zvfkyl	218	51	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	218	52	complex	complex	NN
cord-292688-w4zvfkyl	218	53	[	[	-LRB-
cord-292688-w4zvfkyl	218	54	99	99	CD
cord-292688-w4zvfkyl	218	55	]	]	-RRB-
cord-292688-w4zvfkyl	218	56	.	.	.
cord-292688-w4zvfkyl	219	1	OCRL	OCRL	NNP
cord-292688-w4zvfkyl	219	2	dephosphorylates	dephosphorylate	NNS
cord-292688-w4zvfkyl	219	3	Ins-(1,3,4,5)P	Ins-(1,3,4,5)P	NNP
cord-292688-w4zvfkyl	219	4	4	4	CD
cord-292688-w4zvfkyl	219	5	,	,	,
cord-292688-w4zvfkyl	219	6	Ins(3,4,5)P	Ins(3,4,5)P	NNP
cord-292688-w4zvfkyl	219	7	3	3	CD
cord-292688-w4zvfkyl	219	8	and	and	CC
cord-292688-w4zvfkyl	220	1	most	most	RBS
cord-292688-w4zvfkyl	220	2	importantly	importantly	RB
cord-292688-w4zvfkyl	220	3	PIP	PIP	NNP
cord-292688-w4zvfkyl	220	4	2	2	CD
cord-292688-w4zvfkyl	220	5	in	in	IN
cord-292688-w4zvfkyl	220	6	vitro	vitro	FW
cord-292688-w4zvfkyl	220	7	and	and	CC
cord-292688-w4zvfkyl	220	8	seems	seem	VBZ
cord-292688-w4zvfkyl	220	9	to	to	TO
cord-292688-w4zvfkyl	220	10	act	act	VB
cord-292688-w4zvfkyl	220	11	preferentially	preferentially	RB
cord-292688-w4zvfkyl	220	12	as	as	IN
cord-292688-w4zvfkyl	220	13	a	a	DT
cord-292688-w4zvfkyl	220	14	lipidphosphatase	lipidphosphatase	NN
cord-292688-w4zvfkyl	220	15	in	in	IN
cord-292688-w4zvfkyl	220	16	vivo	vivo	NN
cord-292688-w4zvfkyl	220	17	,	,	,
cord-292688-w4zvfkyl	220	18	and	and	CC
cord-292688-w4zvfkyl	220	19	could	could	MD
cord-292688-w4zvfkyl	220	20	therefore	therefore	RB
cord-292688-w4zvfkyl	220	21	regulate	regulate	VB
cord-292688-w4zvfkyl	220	22	the	the	DT
cord-292688-w4zvfkyl	220	23	levels	level	NNS
cord-292688-w4zvfkyl	220	24	of	of	IN
cord-292688-w4zvfkyl	220	25	PIP	PIP	NNP
cord-292688-w4zvfkyl	220	26	2	2	CD
cord-292688-w4zvfkyl	220	27	in	in	IN
cord-292688-w4zvfkyl	220	28	the	the	DT
cord-292688-w4zvfkyl	220	29	Golgi	golgi	NN
cord-292688-w4zvfkyl	220	30	-	-	HYPH
cord-292688-w4zvfkyl	220	31	membrane	membrane	NN
cord-292688-w4zvfkyl	220	32	[	[	-LRB-
cord-292688-w4zvfkyl	220	33	100	100	CD
cord-292688-w4zvfkyl	220	34	]	]	-RRB-
cord-292688-w4zvfkyl	220	35	.	.	.
cord-292688-w4zvfkyl	221	1	Another	another	DT
cord-292688-w4zvfkyl	221	2	inositol-5-phosphatase	inositol-5-phosphatase	NNP
cord-292688-w4zvfkyl	221	3	,	,	,
cord-292688-w4zvfkyl	221	4	synaptojanin	synaptojanin	NNP
cord-292688-w4zvfkyl	221	5	,	,	,
cord-292688-w4zvfkyl	221	6	has	have	VBZ
cord-292688-w4zvfkyl	221	7	been	be	VBN
cord-292688-w4zvfkyl	221	8	implicated	implicate	VBN
cord-292688-w4zvfkyl	221	9	in	in	IN
cord-292688-w4zvfkyl	221	10	the	the	DT
cord-292688-w4zvfkyl	221	11	recycling	recycling	NN
cord-292688-w4zvfkyl	221	12	of	of	IN
cord-292688-w4zvfkyl	221	13	synaptic	synaptic	JJ
cord-292688-w4zvfkyl	221	14	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	221	15	,	,	,
cord-292688-w4zvfkyl	221	16	a	a	DT
cord-292688-w4zvfkyl	221	17	process	process	NN
cord-292688-w4zvfkyl	221	18	that	that	WDT
cord-292688-w4zvfkyl	221	19	involves	involve	VBZ
cord-292688-w4zvfkyl	221	20	the	the	DT
cord-292688-w4zvfkyl	221	21	formation	formation	NN
cord-292688-w4zvfkyl	221	22	of	of	IN
cord-292688-w4zvfkyl	221	23	clathrincoated	clathrincoate	VBN
cord-292688-w4zvfkyl	221	24	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	221	25	[	[	-LRB-
cord-292688-w4zvfkyl	221	26	101	101	CD
cord-292688-w4zvfkyl	221	27	]	]	-RRB-
cord-292688-w4zvfkyl	221	28	.	.	.
cord-292688-w4zvfkyl	222	1	Synaptojanin	Synaptojanin	NNP
cord-292688-w4zvfkyl	222	2	interacts	interact	VBZ
cord-292688-w4zvfkyl	222	3	through	through	IN
cord-292688-w4zvfkyl	222	4	amphiphysin	amphiphysin	NNP
cord-292688-w4zvfkyl	222	5	[	[	-LRB-
cord-292688-w4zvfkyl	222	6	102	102	CD
cord-292688-w4zvfkyl	222	7	]	]	-RRB-
cord-292688-w4zvfkyl	222	8	with	with	IN
cord-292688-w4zvfkyl	222	9	the	the	DT
cord-292688-w4zvfkyl	222	10	small	small	JJ
cord-292688-w4zvfkyl	222	11	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	222	12	dynamin	dynamin	NN
cord-292688-w4zvfkyl	222	13	which	which	WDT
cord-292688-w4zvfkyl	222	14	appears	appear	VBZ
cord-292688-w4zvfkyl	222	15	to	to	TO
cord-292688-w4zvfkyl	222	16	play	play	VB
cord-292688-w4zvfkyl	222	17	an	an	DT
cord-292688-w4zvfkyl	222	18	important	important	JJ
cord-292688-w4zvfkyl	222	19	role	role	NN
cord-292688-w4zvfkyl	222	20	in	in	IN
cord-292688-w4zvfkyl	222	21	the	the	DT
cord-292688-w4zvfkyl	222	22	budding	budding	NN
cord-292688-w4zvfkyl	222	23	of	of	IN
cord-292688-w4zvfkyl	222	24	clathrin	clathrin	NN
cord-292688-w4zvfkyl	222	25	-	-	HYPH
cord-292688-w4zvfkyl	222	26	coated	coat	VBN
cord-292688-w4zvfkyl	222	27	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	222	28	from	from	IN
cord-292688-w4zvfkyl	222	29	the	the	DT
cord-292688-w4zvfkyl	222	30	plasmamembrane	plasmamembrane	NNP
cord-292688-w4zvfkyl	222	31	(	(	-LRB-
cord-292688-w4zvfkyl	222	32	for	for	IN
cord-292688-w4zvfkyl	222	33	reviews	review	NNS
cord-292688-w4zvfkyl	222	34	see	see	VBP
cord-292688-w4zvfkyl	222	35	[	[	-LRB-
cord-292688-w4zvfkyl	222	36	103	103	CD
cord-292688-w4zvfkyl	222	37	^	^	SYM
cord-292688-w4zvfkyl	222	38	105	105	CD
cord-292688-w4zvfkyl	222	39	]	]	-RRB-
cord-292688-w4zvfkyl	222	40	)	)	-RRB-
cord-292688-w4zvfkyl	222	41	.	.	.
cord-292688-w4zvfkyl	223	1	Although	although	IN
cord-292688-w4zvfkyl	223	2	the	the	DT
cord-292688-w4zvfkyl	223	3	function	function	NN
cord-292688-w4zvfkyl	223	4	of	of	IN
cord-292688-w4zvfkyl	223	5	dynamin	dynamin	NNP
cord-292688-w4zvfkyl	223	6	has	have	VBZ
cord-292688-w4zvfkyl	223	7	predominantly	predominantly	RB
cord-292688-w4zvfkyl	223	8	,	,	,
cord-292688-w4zvfkyl	223	9	but	but	CC
cord-292688-w4zvfkyl	223	10	not	not	RB
cord-292688-w4zvfkyl	223	11	exclusively	exclusively	RB
cord-292688-w4zvfkyl	223	12	[	[	-LRB-
cord-292688-w4zvfkyl	223	13	106	106	CD
cord-292688-w4zvfkyl	223	14	]	]	-RRB-
cord-292688-w4zvfkyl	223	15	,	,	,
cord-292688-w4zvfkyl	223	16	been	be	VBN
cord-292688-w4zvfkyl	223	17	linked	link	VBN
cord-292688-w4zvfkyl	223	18	to	to	IN
cord-292688-w4zvfkyl	223	19	the	the	DT
cord-292688-w4zvfkyl	223	20	function	function	NN
cord-292688-w4zvfkyl	223	21	of	of	IN
cord-292688-w4zvfkyl	223	22	clathrin	clathrin	NN
cord-292688-w4zvfkyl	223	23	,	,	,
cord-292688-w4zvfkyl	223	24	it	-PRON-	PRP
cord-292688-w4zvfkyl	223	25	has	have	VBZ
cord-292688-w4zvfkyl	223	26	been	be	VBN
cord-292688-w4zvfkyl	223	27	speculated	speculate	VBN
cord-292688-w4zvfkyl	223	28	that	that	IN
cord-292688-w4zvfkyl	223	29	there	there	EX
cord-292688-w4zvfkyl	223	30	might	may	MD
cord-292688-w4zvfkyl	223	31	be	be	VB
cord-292688-w4zvfkyl	223	32	a	a	DT
cord-292688-w4zvfkyl	223	33	dynamin	dynamin	NN
cord-292688-w4zvfkyl	223	34	for	for	IN
cord-292688-w4zvfkyl	223	35	every	every	DT
cord-292688-w4zvfkyl	223	36	budding	bud	VBG
cord-292688-w4zvfkyl	223	37	event	event	NN
cord-292688-w4zvfkyl	223	38	in	in	IN
cord-292688-w4zvfkyl	223	39	the	the	DT
cord-292688-w4zvfkyl	223	40	cell	cell	NN
cord-292688-w4zvfkyl	223	41	[	[	-LRB-
cord-292688-w4zvfkyl	223	42	107	107	CD
cord-292688-w4zvfkyl	223	43	]	]	-RRB-
cord-292688-w4zvfkyl	223	44	.	.	.
cord-292688-w4zvfkyl	224	1	A	a	DT
cord-292688-w4zvfkyl	224	2	protein	protein	NN
cord-292688-w4zvfkyl	224	3	with	with	IN
cord-292688-w4zvfkyl	224	4	immunoreactivity	immunoreactivity	NN
cord-292688-w4zvfkyl	224	5	to	to	IN
cord-292688-w4zvfkyl	224	6	antibodies	antibody	NNS
cord-292688-w4zvfkyl	224	7	raised	raise	VBN
cord-292688-w4zvfkyl	224	8	against	against	IN
cord-292688-w4zvfkyl	224	9	conserved	conserved	JJ
cord-292688-w4zvfkyl	224	10	regions	region	NNS
cord-292688-w4zvfkyl	224	11	of	of	IN
cord-292688-w4zvfkyl	224	12	the	the	DT
cord-292688-w4zvfkyl	224	13	dynamin	dynamin	NN
cord-292688-w4zvfkyl	224	14	-	-	HYPH
cord-292688-w4zvfkyl	224	15	family	family	NN
cord-292688-w4zvfkyl	224	16	has	have	VBZ
cord-292688-w4zvfkyl	224	17	been	be	VBN
cord-292688-w4zvfkyl	224	18	localized	localize	VBN
cord-292688-w4zvfkyl	224	19	to	to	IN
cord-292688-w4zvfkyl	224	20	the	the	DT
cord-292688-w4zvfkyl	224	21	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	224	22	complex	complex	NN
cord-292688-w4zvfkyl	224	23	in	in	IN
cord-292688-w4zvfkyl	224	24	¢broblasts	¢broblast	NNS
cord-292688-w4zvfkyl	224	25	and	and	CC
cord-292688-w4zvfkyl	224	26	melanocytes	melanocyte	NNS
cord-292688-w4zvfkyl	224	27	[	[	-LRB-
cord-292688-w4zvfkyl	224	28	108	108	CD
cord-292688-w4zvfkyl	224	29	]	]	-RRB-
cord-292688-w4zvfkyl	224	30	.	.	.
cord-292688-w4zvfkyl	225	1	As	as	IN
cord-292688-w4zvfkyl	225	2	GTP	gtp	NN
cord-292688-w4zvfkyl	225	3	-	-	HYPH
cord-292688-w4zvfkyl	225	4	hydrolysis	hydrolysis	NN
cord-292688-w4zvfkyl	225	5	is	be	VBZ
cord-292688-w4zvfkyl	225	6	required	require	VBN
cord-292688-w4zvfkyl	225	7	for	for	IN
cord-292688-w4zvfkyl	225	8	dynamin	dynamin	NN
cord-292688-w4zvfkyl	225	9	function	function	NN
cord-292688-w4zvfkyl	225	10	it	-PRON-	PRP
cord-292688-w4zvfkyl	225	11	is	be	VBZ
cord-292688-w4zvfkyl	225	12	possible	possible	JJ
cord-292688-w4zvfkyl	225	13	that	that	IN
cord-292688-w4zvfkyl	225	14	the	the	DT
cord-292688-w4zvfkyl	225	15	inhibitory	inhibitory	JJ
cord-292688-w4zvfkyl	225	16	e¡ect	e¡ect	''
cord-292688-w4zvfkyl	225	17	of	of	IN
cord-292688-w4zvfkyl	225	18	GTPQS	GTPQS	NNP
cord-292688-w4zvfkyl	225	19	on	on	IN
cord-292688-w4zvfkyl	225	20	the	the	DT
cord-292688-w4zvfkyl	225	21	budding	budding	NN
cord-292688-w4zvfkyl	225	22	of	of	IN
cord-292688-w4zvfkyl	225	23	secre	secre	NN
cord-292688-w4zvfkyl	225	24	-	-	HYPH
cord-292688-w4zvfkyl	225	25	tory	tory	NN
cord-292688-w4zvfkyl	225	26	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	225	27	from	from	IN
cord-292688-w4zvfkyl	225	28	the	the	DT
cord-292688-w4zvfkyl	225	29	TGN	TGN	NNP
cord-292688-w4zvfkyl	225	30	re£ects	re£ect	VBZ
cord-292688-w4zvfkyl	225	31	not	not	RB
cord-292688-w4zvfkyl	225	32	only	only	RB
cord-292688-w4zvfkyl	225	33	an	an	DT
cord-292688-w4zvfkyl	225	34	involvement	involvement	NN
cord-292688-w4zvfkyl	225	35	of	of	IN
cord-292688-w4zvfkyl	225	36	heterotrimeric	heterotrimeric	JJ
cord-292688-w4zvfkyl	225	37	G	G	NNP
cord-292688-w4zvfkyl	225	38	proteins	protein	NNS
cord-292688-w4zvfkyl	225	39	and	and	CC
cord-292688-w4zvfkyl	225	40	small	small	JJ
cord-292688-w4zvfkyl	225	41	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	225	42	,	,	,
cord-292688-w4zvfkyl	225	43	but	but	CC
cord-292688-w4zvfkyl	225	44	also	also	RB
cord-292688-w4zvfkyl	225	45	of	of	IN
cord-292688-w4zvfkyl	225	46	dynamin	dynamin	NNP
cord-292688-w4zvfkyl	225	47	.	.	.
cord-292688-w4zvfkyl	226	1	Research	research	NN
cord-292688-w4zvfkyl	226	2	on	on	IN
cord-292688-w4zvfkyl	226	3	secretory	secretory	JJ
cord-292688-w4zvfkyl	226	4	granule	granule	NN
cord-292688-w4zvfkyl	226	5	biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	226	6	has	have	VBZ
cord-292688-w4zvfkyl	226	7	revolved	revolve	VBN
cord-292688-w4zvfkyl	226	8	to	to	IN
cord-292688-w4zvfkyl	226	9	a	a	DT
cord-292688-w4zvfkyl	226	10	large	large	JJ
cord-292688-w4zvfkyl	226	11	extent	extent	NN
cord-292688-w4zvfkyl	226	12	around	around	IN
cord-292688-w4zvfkyl	226	13	the	the	DT
cord-292688-w4zvfkyl	226	14	granule	granule	NN
cord-292688-w4zvfkyl	226	15	content	content	NN
cord-292688-w4zvfkyl	226	16	selection	selection	NN
cord-292688-w4zvfkyl	226	17	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	226	18	.	.	.
cord-292688-w4zvfkyl	227	1	The	the	DT
cord-292688-w4zvfkyl	227	2	only	only	JJ
cord-292688-w4zvfkyl	227	3	coat	coat	NN
cord-292688-w4zvfkyl	227	4	-	-	HYPH
cord-292688-w4zvfkyl	227	5	proteins	protein	NNS
cord-292688-w4zvfkyl	227	6	identi-¢ed	identi-¢ed	.
cord-292688-w4zvfkyl	228	1	so	so	RB
cord-292688-w4zvfkyl	228	2	far	far	RB
cord-292688-w4zvfkyl	228	3	on	on	IN
cord-292688-w4zvfkyl	228	4	the	the	DT
cord-292688-w4zvfkyl	228	5	secretory	secretory	JJ
cord-292688-w4zvfkyl	228	6	granule	granule	NN
cord-292688-w4zvfkyl	228	7	,	,	,
cord-292688-w4zvfkyl	228	8	which	which	WDT
cord-292688-w4zvfkyl	228	9	are	be	VBP
cord-292688-w4zvfkyl	228	10	present	present	JJ
cord-292688-w4zvfkyl	228	11	only	only	RB
cord-292688-w4zvfkyl	228	12	on	on	IN
cord-292688-w4zvfkyl	228	13	ISGs	isg	NNS
cord-292688-w4zvfkyl	228	14	are	be	VBP
cord-292688-w4zvfkyl	228	15	clathrin	clathrin	NN
cord-292688-w4zvfkyl	228	16	and	and	CC
cord-292688-w4zvfkyl	228	17	adaptor	adaptor	NN
cord-292688-w4zvfkyl	228	18	-	-	HYPH
cord-292688-w4zvfkyl	228	19	complex	complex	JJ
cord-292688-w4zvfkyl	228	20	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	228	21	,	,	,
cord-292688-w4zvfkyl	228	22	and	and	CC
cord-292688-w4zvfkyl	228	23	they	-PRON-	PRP
cord-292688-w4zvfkyl	228	24	function	function	VBP
cord-292688-w4zvfkyl	228	25	to	to	TO
cord-292688-w4zvfkyl	228	26	mediate	mediate	VB
cord-292688-w4zvfkyl	228	27	vesicle	vesicle	NN
cord-292688-w4zvfkyl	228	28	budding	bud	VBG
cord-292688-w4zvfkyl	228	29	from	from	IN
cord-292688-w4zvfkyl	228	30	the	the	DT
cord-292688-w4zvfkyl	228	31	ISG	ISG	NNP
cord-292688-w4zvfkyl	228	32	rather	rather	RB
cord-292688-w4zvfkyl	228	33	than	than	IN
cord-292688-w4zvfkyl	228	34	formation	formation	NN
cord-292688-w4zvfkyl	228	35	of	of	IN
cord-292688-w4zvfkyl	228	36	the	the	DT
cord-292688-w4zvfkyl	228	37	ISG	ISG	NNP
cord-292688-w4zvfkyl	228	38	from	from	IN
cord-292688-w4zvfkyl	228	39	the	the	DT
cord-292688-w4zvfkyl	228	40	TGN	TGN	NNP
cord-292688-w4zvfkyl	228	41	[	[	-LRB-
cord-292688-w4zvfkyl	228	42	109	109	CD
cord-292688-w4zvfkyl	228	43	]	]	-RRB-
cord-292688-w4zvfkyl	228	44	.	.	.
cord-292688-w4zvfkyl	229	1	It	-PRON-	PRP
cord-292688-w4zvfkyl	229	2	has	have	VBZ
cord-292688-w4zvfkyl	229	3	been	be	VBN
cord-292688-w4zvfkyl	229	4	suggested	suggest	VBN
cord-292688-w4zvfkyl	229	5	that	that	IN
cord-292688-w4zvfkyl	229	6	budding	budding	NN
cord-292688-w4zvfkyl	229	7	of	of	IN
cord-292688-w4zvfkyl	229	8	nascent	nascent	JJ
cord-292688-w4zvfkyl	229	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	229	10	granules	granule	NNS
cord-292688-w4zvfkyl	229	11	does	do	VBZ
cord-292688-w4zvfkyl	229	12	not	not	RB
cord-292688-w4zvfkyl	229	13	require	require	VB
cord-292688-w4zvfkyl	229	14	a	a	DT
cord-292688-w4zvfkyl	229	15	coat	coat	NN
cord-292688-w4zvfkyl	229	16	protein	protein	NN
cord-292688-w4zvfkyl	229	17	,	,	,
cord-292688-w4zvfkyl	229	18	but	but	CC
cord-292688-w4zvfkyl	229	19	that	that	IN
cord-292688-w4zvfkyl	229	20	the	the	DT
cord-292688-w4zvfkyl	229	21	aggregated	aggregated	JJ
cord-292688-w4zvfkyl	229	22	core	core	NN
cord-292688-w4zvfkyl	229	23	of	of	IN
cord-292688-w4zvfkyl	229	24	the	the	DT
cord-292688-w4zvfkyl	229	25	granule	granule	NN
cord-292688-w4zvfkyl	229	26	is	be	VBZ
cord-292688-w4zvfkyl	229	27	able	able	JJ
cord-292688-w4zvfkyl	229	28	to`drive	to`drive	JJ
cord-292688-w4zvfkyl	229	29	'	'	``
cord-292688-w4zvfkyl	229	30	vesicle	vesicle	NN
cord-292688-w4zvfkyl	229	31	formation	formation	NN
cord-292688-w4zvfkyl	229	32	in	in	IN
cord-292688-w4zvfkyl	229	33	a	a	DT
cord-292688-w4zvfkyl	229	34	way	way	NN
cord-292688-w4zvfkyl	229	35	analogous	analogous	JJ
cord-292688-w4zvfkyl	229	36	to	to	IN
cord-292688-w4zvfkyl	229	37	the	the	DT
cord-292688-w4zvfkyl	229	38	budding	budding	NN
cord-292688-w4zvfkyl	229	39	of	of	IN
cord-292688-w4zvfkyl	229	40	a	a	DT
cord-292688-w4zvfkyl	229	41	viral	viral	JJ
cord-292688-w4zvfkyl	229	42	particle	particle	NN
cord-292688-w4zvfkyl	229	43	.	.	.
cord-292688-w4zvfkyl	230	1	This	this	DT
cord-292688-w4zvfkyl	230	2	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	230	3	predicts	predict	VBZ
cord-292688-w4zvfkyl	230	4	that	that	IN
cord-292688-w4zvfkyl	230	5	there	there	EX
cord-292688-w4zvfkyl	230	6	have	have	VBP
cord-292688-w4zvfkyl	230	7	to	to	TO
cord-292688-w4zvfkyl	230	8	be	be	VB
cord-292688-w4zvfkyl	230	9	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	230	10	interactions	interaction	NNS
cord-292688-w4zvfkyl	230	11	between	between	IN
cord-292688-w4zvfkyl	230	12	the	the	DT
cord-292688-w4zvfkyl	230	13	granule	granule	NN
cord-292688-w4zvfkyl	230	14	core	core	NN
cord-292688-w4zvfkyl	230	15	and	and	CC
cord-292688-w4zvfkyl	230	16	the	the	DT
cord-292688-w4zvfkyl	230	17	granule	granule	NN
cord-292688-w4zvfkyl	230	18	membrane	membrane	NN
cord-292688-w4zvfkyl	230	19	that	that	WDT
cord-292688-w4zvfkyl	230	20	mirror	mirror	VBP
cord-292688-w4zvfkyl	230	21	the	the	DT
cord-292688-w4zvfkyl	230	22	binding	binding	NN
cord-292688-w4zvfkyl	230	23	of	of	IN
cord-292688-w4zvfkyl	230	24	viral	viral	JJ
cord-292688-w4zvfkyl	230	25	nucleocapsid	nucleocapsid	NN
cord-292688-w4zvfkyl	230	26	proteins	protein	NNS
cord-292688-w4zvfkyl	230	27	to	to	IN
cord-292688-w4zvfkyl	230	28	the	the	DT
cord-292688-w4zvfkyl	230	29	membrane	membrane	NN
cord-292688-w4zvfkyl	230	30	-	-	HYPH
cord-292688-w4zvfkyl	230	31	bound	bind	VBN
cord-292688-w4zvfkyl	230	32	envelope	envelope	NN
cord-292688-w4zvfkyl	230	33	proteins	protein	NNS
cord-292688-w4zvfkyl	230	34	.	.	.
cord-292688-w4zvfkyl	231	1	In	in	IN
cord-292688-w4zvfkyl	231	2	this	this	DT
cord-292688-w4zvfkyl	231	3	way	way	NN
cord-292688-w4zvfkyl	231	4	the	the	DT
cord-292688-w4zvfkyl	231	5	secretory	secretory	JJ
cord-292688-w4zvfkyl	231	6	granule	granule	NN
cord-292688-w4zvfkyl	231	7	core	core	NN
cord-292688-w4zvfkyl	231	8	could	could	MD
cord-292688-w4zvfkyl	231	9	mould	mould	VB
cord-292688-w4zvfkyl	231	10	its	-PRON-	PRP$
cord-292688-w4zvfkyl	231	11	own	own	JJ
cord-292688-w4zvfkyl	231	12	membrane	membrane	NN
cord-292688-w4zvfkyl	231	13	,	,	,
cord-292688-w4zvfkyl	231	14	driven	drive	VBN
cord-292688-w4zvfkyl	231	15	only	only	RB
cord-292688-w4zvfkyl	231	16	by	by	IN
cord-292688-w4zvfkyl	231	17	a	a	DT
cord-292688-w4zvfkyl	231	18	thermodynamically	thermodynamically	RB
cord-292688-w4zvfkyl	231	19	favourable	favourable	JJ
cord-292688-w4zvfkyl	231	20	binding	binding	NN
cord-292688-w4zvfkyl	231	21	of	of	IN
cord-292688-w4zvfkyl	231	22	granule	granule	NN
cord-292688-w4zvfkyl	231	23	membrane	membrane	NN
cord-292688-w4zvfkyl	231	24	proteins	protein	NNS
cord-292688-w4zvfkyl	231	25	with	with	IN
cord-292688-w4zvfkyl	231	26	the	the	DT
cord-292688-w4zvfkyl	231	27	aggregating	aggregate	VBG
cord-292688-w4zvfkyl	231	28	content	content	NN
cord-292688-w4zvfkyl	231	29	.	.	.
cord-292688-w4zvfkyl	232	1	This	this	DT
cord-292688-w4zvfkyl	232	2	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	232	3	becomes	become	VBZ
cord-292688-w4zvfkyl	232	4	less	less	RBR
cord-292688-w4zvfkyl	232	5	attractive	attractive	JJ
cord-292688-w4zvfkyl	232	6	if	if	IN
cord-292688-w4zvfkyl	232	7	the	the	DT
cord-292688-w4zvfkyl	232	8	nascent	nascent	JJ
cord-292688-w4zvfkyl	232	9	ISG	ISG	NNP
cord-292688-w4zvfkyl	232	10	contains	contain	VBZ
cord-292688-w4zvfkyl	232	11	largely	largely	RB
cord-292688-w4zvfkyl	232	12	uncondensed	uncondense	VBN
cord-292688-w4zvfkyl	232	13	,	,	,
cord-292688-w4zvfkyl	232	14	unaggregated	unaggregated	JJ
cord-292688-w4zvfkyl	232	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	232	16	proteins	protein	NNS
cord-292688-w4zvfkyl	232	17	which	which	WDT
cord-292688-w4zvfkyl	232	18	,	,	,
cord-292688-w4zvfkyl	232	19	along	along	IN
cord-292688-w4zvfkyl	232	20	with	with	IN
cord-292688-w4zvfkyl	232	21	the	the	DT
cord-292688-w4zvfkyl	232	22	membrane	membrane	NN
cord-292688-w4zvfkyl	232	23	proteins	protein	NNS
cord-292688-w4zvfkyl	232	24	,	,	,
cord-292688-w4zvfkyl	232	25	are	be	VBP
cord-292688-w4zvfkyl	232	26	not	not	RB
cord-292688-w4zvfkyl	232	27	sorted	sort	VBN
cord-292688-w4zvfkyl	232	28	prior	prior	RB
cord-292688-w4zvfkyl	232	29	to	to	IN
cord-292688-w4zvfkyl	232	30	budding	bud	VBG
cord-292688-w4zvfkyl	232	31	(	(	-LRB-
cord-292688-w4zvfkyl	232	32	see	see	VB
cord-292688-w4zvfkyl	232	33	the	the	DT
cord-292688-w4zvfkyl	232	34	sorting	sorting	NN
cord-292688-w4zvfkyl	232	35	by	by	IN
cord-292688-w4zvfkyl	232	36	retention	retention	NN
cord-292688-w4zvfkyl	232	37	model	model	NN
cord-292688-w4zvfkyl	232	38	above	above	RB
cord-292688-w4zvfkyl	232	39	)	)	-RRB-
cord-292688-w4zvfkyl	232	40	.	.	.
cord-292688-w4zvfkyl	233	1	Work	work	VB
cord-292688-w4zvfkyl	233	2	on	on	IN
cord-292688-w4zvfkyl	233	3	this	this	DT
cord-292688-w4zvfkyl	233	4	sorting	sorting	NN
cord-292688-w4zvfkyl	233	5	mechanism	mechanism	NN
cord-292688-w4zvfkyl	233	6	is	be	VBZ
cord-292688-w4zvfkyl	233	7	in	in	IN
cord-292688-w4zvfkyl	233	8	progress	progress	NN
cord-292688-w4zvfkyl	233	9	and	and	CC
cord-292688-w4zvfkyl	233	10	new	new	JJ
cord-292688-w4zvfkyl	233	11	results	result	NNS
cord-292688-w4zvfkyl	233	12	will	will	MD
cord-292688-w4zvfkyl	233	13	no	no	RB
cord-292688-w4zvfkyl	233	14	doubt	doubt	RB
cord-292688-w4zvfkyl	233	15	be	be	VB
cord-292688-w4zvfkyl	233	16	forthcoming	forthcoming	JJ
cord-292688-w4zvfkyl	233	17	to	to	TO
cord-292688-w4zvfkyl	233	18	clarify	clarify	VB
cord-292688-w4zvfkyl	233	19	the	the	DT
cord-292688-w4zvfkyl	233	20	inconsistencies	inconsistency	NNS
cord-292688-w4zvfkyl	233	21	present	present	JJ
cord-292688-w4zvfkyl	233	22	.	.	.
cord-292688-w4zvfkyl	234	1	To	to	TO
cord-292688-w4zvfkyl	234	2	address	address	VB
cord-292688-w4zvfkyl	234	3	these	these	DT
cord-292688-w4zvfkyl	234	4	questions	question	NNS
cord-292688-w4zvfkyl	234	5	,	,	,
cord-292688-w4zvfkyl	234	6	it	-PRON-	PRP
cord-292688-w4zvfkyl	234	7	would	would	MD
cord-292688-w4zvfkyl	234	8	be	be	VB
cord-292688-w4zvfkyl	234	9	most	most	RBS
cord-292688-w4zvfkyl	234	10	interesting	interesting	JJ
cord-292688-w4zvfkyl	234	11	to	to	TO
cord-292688-w4zvfkyl	234	12	have	have	VB
cord-292688-w4zvfkyl	234	13	an	an	DT
cord-292688-w4zvfkyl	234	14	in	in	FW
cord-292688-w4zvfkyl	234	15	vitro	vitro	FW
cord-292688-w4zvfkyl	234	16	system	system	NN
cord-292688-w4zvfkyl	234	17	for	for	IN
cord-292688-w4zvfkyl	234	18	formation	formation	NN
cord-292688-w4zvfkyl	234	19	of	of	IN
cord-292688-w4zvfkyl	234	20	ISGs	isg	NNS
cord-292688-w4zvfkyl	234	21	using	use	VBG
cord-292688-w4zvfkyl	234	22	the	the	DT
cord-292688-w4zvfkyl	234	23	cells	cell	NNS
cord-292688-w4zvfkyl	234	24	,	,	,
cord-292688-w4zvfkyl	234	25	or	or	CC
cord-292688-w4zvfkyl	234	26	cell	cell	NN
cord-292688-w4zvfkyl	234	27	lines	line	NNS
cord-292688-w4zvfkyl	234	28	(	(	-LRB-
cord-292688-w4zvfkyl	234	29	i.e.	i.e.	FW
cord-292688-w4zvfkyl	234	30	L	l	NN
cord-292688-w4zvfkyl	234	31	-	-	HYPH
cord-292688-w4zvfkyl	234	32	cells	cell	NNS
cord-292688-w4zvfkyl	234	33	)	)	-RRB-
cord-292688-w4zvfkyl	234	34	,	,	,
cord-292688-w4zvfkyl	234	35	from	from	IN
cord-292688-w4zvfkyl	234	36	which	which	WDT
cord-292688-w4zvfkyl	234	37	the	the	DT
cord-292688-w4zvfkyl	234	38	sorting	sorting	NN
cord-292688-w4zvfkyl	234	39	by	by	IN
cord-292688-w4zvfkyl	234	40	retention	retention	NN
cord-292688-w4zvfkyl	234	41	hypothesis	hypothesis	NN
cord-292688-w4zvfkyl	234	42	has	have	VBZ
cord-292688-w4zvfkyl	234	43	been	be	VBN
cord-292688-w4zvfkyl	234	44	developed	develop	VBN
cord-292688-w4zvfkyl	234	45	.	.	.
cord-292688-w4zvfkyl	235	1	The	the	DT
cord-292688-w4zvfkyl	235	2	development	development	NN
cord-292688-w4zvfkyl	235	3	of	of	IN
cord-292688-w4zvfkyl	235	4	such	such	PDT
cord-292688-w4zvfkyl	235	5	a	a	DT
cord-292688-w4zvfkyl	235	6	system	system	NN
cord-292688-w4zvfkyl	235	7	would	would	MD
cord-292688-w4zvfkyl	235	8	allow	allow	VB
cord-292688-w4zvfkyl	235	9	a	a	DT
cord-292688-w4zvfkyl	235	10	direct	direct	JJ
cord-292688-w4zvfkyl	235	11	test	test	NN
cord-292688-w4zvfkyl	235	12	for	for	IN
cord-292688-w4zvfkyl	235	13	common	common	JJ
cord-292688-w4zvfkyl	235	14	structural	structural	JJ
cord-292688-w4zvfkyl	235	15	and	and	CC
cord-292688-w4zvfkyl	235	16	regulatory	regulatory	JJ
cord-292688-w4zvfkyl	235	17	molecules	molecule	NNS
cord-292688-w4zvfkyl	235	18	involved	involve	VBN
cord-292688-w4zvfkyl	235	19	in	in	IN
cord-292688-w4zvfkyl	235	20	formation	formation	NN
cord-292688-w4zvfkyl	235	21	of	of	IN
cord-292688-w4zvfkyl	235	22	secretory	secretory	JJ
cord-292688-w4zvfkyl	235	23	granules	granule	NNS
cord-292688-w4zvfkyl	235	24	in	in	IN
cord-292688-w4zvfkyl	235	25	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	235	26	and	and	CC
cord-292688-w4zvfkyl	235	27	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	235	28	cells	cell	NNS
cord-292688-w4zvfkyl	235	29	.	.	.
cord-292688-w4zvfkyl	236	1	network	network	NN
cord-292688-w4zvfkyl	236	2	(	(	-LRB-
cord-292688-w4zvfkyl	236	3	ERB	ERB	NNP
cord-292688-w4zvfkyl	236	4	-	-	HYPH
cord-292688-w4zvfkyl	236	5	FMRXCT	FMRXCT	NNP
cord-292688-w4zvfkyl	236	6	960023	960023	CD
cord-292688-w4zvfkyl	236	7	)	)	-RRB-
cord-292688-w4zvfkyl	236	8	for	for	IN
cord-292688-w4zvfkyl	236	9	stimulating	stimulate	VBG
cord-292688-w4zvfkyl	236	10	discussions	discussion	NNS
cord-292688-w4zvfkyl	236	11	on	on	IN
cord-292688-w4zvfkyl	236	12	which	which	WDT
cord-292688-w4zvfkyl	236	13	a	a	DT
cord-292688-w4zvfkyl	236	14	large	large	JJ
cord-292688-w4zvfkyl	236	15	part	part	NN
cord-292688-w4zvfkyl	236	16	of	of	IN
cord-292688-w4zvfkyl	236	17	this	this	DT
cord-292688-w4zvfkyl	236	18	review	review	NN
cord-292688-w4zvfkyl	236	19	is	be	VBZ
cord-292688-w4zvfkyl	236	20	founded	found	VBN
cord-292688-w4zvfkyl	236	21	.	.	.
cord-292688-w4zvfkyl	237	1	In	in	IN
cord-292688-w4zvfkyl	237	2	particular	particular	JJ
cord-292688-w4zvfkyl	237	3	,	,	,
cord-292688-w4zvfkyl	237	4	I	-PRON-	PRP
cord-292688-w4zvfkyl	237	5	thank	thank	VBP
cord-292688-w4zvfkyl	237	6	my	-PRON-	PRP$
cord-292688-w4zvfkyl	237	7	network	network	NN
cord-292688-w4zvfkyl	237	8	colleagues	colleague	NNS
cord-292688-w4zvfkyl	237	9	,	,	,
cord-292688-w4zvfkyl	237	10	Hans	Hans	NNP
cord-292688-w4zvfkyl	237	11	-	-	HYPH
cord-292688-w4zvfkyl	237	12	Hermann	Hermann	NNP
cord-292688-w4zvfkyl	237	13	Gerdes	Gerdes	NNP
cord-292688-w4zvfkyl	237	14	and	and	CC
cord-292688-w4zvfkyl	237	15	Philippe	Philippe	NNP
cord-292688-w4zvfkyl	237	16	Halban	Halban	NNP
cord-292688-w4zvfkyl	237	17	for	for	IN
cord-292688-w4zvfkyl	237	18	copies	copy	NNS
cord-292688-w4zvfkyl	237	19	of	of	IN
cord-292688-w4zvfkyl	237	20	manuscripts	manuscript	NNS
cord-292688-w4zvfkyl	237	21	before	before	IN
cord-292688-w4zvfkyl	237	22	publication	publication	NN
cord-292688-w4zvfkyl	237	23	.	.	.
cord-292688-w4zvfkyl	238	1	Finally	finally	RB
cord-292688-w4zvfkyl	238	2	,	,	,
cord-292688-w4zvfkyl	238	3	I	-PRON-	PRP
cord-292688-w4zvfkyl	238	4	wish	wish	VBP
cord-292688-w4zvfkyl	238	5	to	to	TO
cord-292688-w4zvfkyl	238	6	thank	thank	VB
cord-292688-w4zvfkyl	238	7	Peter	Peter	NNP
cord-292688-w4zvfkyl	238	8	Arvan	Arvan	NNP
cord-292688-w4zvfkyl	238	9	for	for	IN
cord-292688-w4zvfkyl	238	10	taking	take	VBG
cord-292688-w4zvfkyl	238	11	the	the	DT
cord-292688-w4zvfkyl	238	12	time	time	NN
cord-292688-w4zvfkyl	238	13	to	to	TO
cord-292688-w4zvfkyl	238	14	read	read	VB
cord-292688-w4zvfkyl	238	15	this	this	DT
cord-292688-w4zvfkyl	238	16	review	review	NN
cord-292688-w4zvfkyl	238	17	and	and	CC
cord-292688-w4zvfkyl	238	18	for	for	IN
cord-292688-w4zvfkyl	238	19	his	-PRON-	PRP$
cord-292688-w4zvfkyl	238	20	valuable	valuable	JJ
cord-292688-w4zvfkyl	238	21	comments	comment	NNS
cord-292688-w4zvfkyl	238	22	.	.	.
cord-292688-w4zvfkyl	239	1	The	the	DT
cord-292688-w4zvfkyl	239	2	granin	granin	NNS
cord-292688-w4zvfkyl	239	3	(	(	-LRB-
cord-292688-w4zvfkyl	239	4	chromogranin	chromogranin	NNP
cord-292688-w4zvfkyl	239	5	/	/	SYM
cord-292688-w4zvfkyl	239	6	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	239	7	)	)	-RRB-
cord-292688-w4zvfkyl	239	8	family	family	NN
cord-292688-w4zvfkyl	240	1	What	what	WP
cord-292688-w4zvfkyl	240	2	the	the	DT
cord-292688-w4zvfkyl	240	3	granins	granin	NNS
cord-292688-w4zvfkyl	240	4	tell	tell	VBP
cord-292688-w4zvfkyl	240	5	us	-PRON-	PRP
cord-292688-w4zvfkyl	240	6	about	about	IN
cord-292688-w4zvfkyl	240	7	the	the	DT
cord-292688-w4zvfkyl	240	8	formation	formation	NN
cord-292688-w4zvfkyl	240	9	of	of	IN
cord-292688-w4zvfkyl	240	10	secretory	secretory	JJ
cord-292688-w4zvfkyl	240	11	granules	granule	NNS
cord-292688-w4zvfkyl	240	12	in	in	IN
cord-292688-w4zvfkyl	240	13	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	240	14	cells	cell	NNS
cord-292688-w4zvfkyl	240	15	Regulated	regulate	VBN
cord-292688-w4zvfkyl	240	16	secretion	secretion	NN
cord-292688-w4zvfkyl	240	17	.	.	.
cord-292688-w4zvfkyl	241	1	Helper	helper	NN
cord-292688-w4zvfkyl	241	2	proteins	protein	NNS
cord-292688-w4zvfkyl	241	3	for	for	IN
cord-292688-w4zvfkyl	241	4	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	241	5	secretion	secretion	NN
cord-292688-w4zvfkyl	241	6	Chromogranin	Chromogranin	NNP
cord-292688-w4zvfkyl	241	7	B	B	NNP
cord-292688-w4zvfkyl	241	8	(	(	-LRB-
cord-292688-w4zvfkyl	241	9	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	241	10	I	i	CD
cord-292688-w4zvfkyl	241	11	)	)	-RRB-
cord-292688-w4zvfkyl	241	12	promotes	promote	VBZ
cord-292688-w4zvfkyl	241	13	sorting	sorting	NN
cord-292688-w4zvfkyl	241	14	to	to	IN
cord-292688-w4zvfkyl	241	15	the	the	DT
cord-292688-w4zvfkyl	241	16	regulated	regulate	VBN
cord-292688-w4zvfkyl	241	17	secretory	secretory	JJ
cord-292688-w4zvfkyl	241	18	pathway	pathway	NN
cord-292688-w4zvfkyl	241	19	of	of	IN
cord-292688-w4zvfkyl	241	20	processing	processing	NN
cord-292688-w4zvfkyl	241	21	intermediates	intermediate	NNS
cord-292688-w4zvfkyl	241	22	derived	derive	VBN
cord-292688-w4zvfkyl	241	23	from	from	IN
cord-292688-w4zvfkyl	241	24	a	a	DT
cord-292688-w4zvfkyl	241	25	peptide	peptide	JJ
cord-292688-w4zvfkyl	241	26	hormone	hormone	NN
cord-292688-w4zvfkyl	241	27	precursor	precursor	NN
cord-292688-w4zvfkyl	242	1	The	the	DT
cord-292688-w4zvfkyl	242	2	primary	primary	JJ
cord-292688-w4zvfkyl	242	3	structure	structure	NN
cord-292688-w4zvfkyl	242	4	of	of	IN
cord-292688-w4zvfkyl	242	5	human	human	JJ
cord-292688-w4zvfkyl	242	6	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	242	7	II	II	NNP
cord-292688-w4zvfkyl	242	8	,	,	,
cord-292688-w4zvfkyl	242	9	a	a	DT
cord-292688-w4zvfkyl	242	10	widespread	widespread	JJ
cord-292688-w4zvfkyl	242	11	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	242	12	-	-	HYPH
cord-292688-w4zvfkyl	242	13	sulfated	sulfate	VBN
cord-292688-w4zvfkyl	242	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	242	15	granule	granule	NN
cord-292688-w4zvfkyl	242	16	protein	protein	NN
cord-292688-w4zvfkyl	242	17	that	that	WDT
cord-292688-w4zvfkyl	242	18	exhibits	exhibit	VBZ
cord-292688-w4zvfkyl	242	19	low	low	JJ
cord-292688-w4zvfkyl	242	20	pH	ph	NN
cord-292688-w4zvfkyl	242	21	-	-	:
cord-292688-w4zvfkyl	242	22	and	and	CC
cord-292688-w4zvfkyl	242	23	calcium	calcium	NN
cord-292688-w4zvfkyl	242	24	-	-	HYPH
cord-292688-w4zvfkyl	242	25	induced	induce	VBN
cord-292688-w4zvfkyl	242	26	aggregation	aggregation	NN
cord-292688-w4zvfkyl	242	27	Milieu	Milieu	NNP
cord-292688-w4zvfkyl	242	28	-	-	HYPH
cord-292688-w4zvfkyl	242	29	induced	induce	VBN
cord-292688-w4zvfkyl	242	30	,	,	,
cord-292688-w4zvfkyl	242	31	selective	selective	JJ
cord-292688-w4zvfkyl	242	32	aggregation	aggregation	NN
cord-292688-w4zvfkyl	242	33	of	of	IN
cord-292688-w4zvfkyl	242	34	regulated	regulate	VBN
cord-292688-w4zvfkyl	242	35	secretory	secretory	JJ
cord-292688-w4zvfkyl	242	36	proteins	protein	NNS
cord-292688-w4zvfkyl	242	37	in	in	IN
cord-292688-w4zvfkyl	242	38	the	the	DT
cord-292688-w4zvfkyl	242	39	trans	trans	NNP
cord-292688-w4zvfkyl	242	40	-	-	NNP
cord-292688-w4zvfkyl	242	41	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	242	42	network	network	NN
cord-292688-w4zvfkyl	242	43	Calcium	calcium	NN
cord-292688-w4zvfkyl	242	44	-	-	:
cord-292688-w4zvfkyl	242	45	and	and	CC
cord-292688-w4zvfkyl	242	46	pHdependent	pHdependent	NNP
cord-292688-w4zvfkyl	242	47	aggregation	aggregation	NN
cord-292688-w4zvfkyl	242	48	and	and	CC
cord-292688-w4zvfkyl	242	49	membrane	membrane	NNP
cord-292688-w4zvfkyl	242	50	association	association	NNP
cord-292688-w4zvfkyl	242	51	of	of	IN
cord-292688-w4zvfkyl	242	52	the	the	DT
cord-292688-w4zvfkyl	242	53	precursor	precursor	NN
cord-292688-w4zvfkyl	242	54	of	of	IN
cord-292688-w4zvfkyl	242	55	the	the	DT
cord-292688-w4zvfkyl	242	56	prohormone	prohormone	NN
cord-292688-w4zvfkyl	242	57	convertase	convertase	NN
cord-292688-w4zvfkyl	242	58	PC2	PC2	NNP
cord-292688-w4zvfkyl	242	59	Secretory	secretory	JJ
cord-292688-w4zvfkyl	242	60	granule	granule	NN
cord-292688-w4zvfkyl	242	61	content	content	NN
cord-292688-w4zvfkyl	242	62	proteins	protein	NNS
cord-292688-w4zvfkyl	242	63	and	and	CC
cord-292688-w4zvfkyl	242	64	the	the	DT
cord-292688-w4zvfkyl	242	65	luminal	luminal	JJ
cord-292688-w4zvfkyl	242	66	domains	domain	NNS
cord-292688-w4zvfkyl	242	67	of	of	IN
cord-292688-w4zvfkyl	242	68	granule	granule	NN
cord-292688-w4zvfkyl	242	69	membrane	membrane	NN
cord-292688-w4zvfkyl	242	70	proteins	protein	NNS
cord-292688-w4zvfkyl	242	71	aggregate	aggregate	VBP
cord-292688-w4zvfkyl	242	72	in	in	IN
cord-292688-w4zvfkyl	242	73	vitro	vitro	FW
cord-292688-w4zvfkyl	242	74	at	at	IN
cord-292688-w4zvfkyl	242	75	mildly	mildly	RB
cord-292688-w4zvfkyl	242	76	acidic	acidic	JJ
cord-292688-w4zvfkyl	242	77	pH	pH	NNP
cord-292688-w4zvfkyl	242	78	Conversion	conversion	NN
cord-292688-w4zvfkyl	242	79	of	of	IN
cord-292688-w4zvfkyl	242	80	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	242	81	to	to	IN
cord-292688-w4zvfkyl	242	82	insulin	insulin	NN
cord-292688-w4zvfkyl	242	83	occurs	occur	VBZ
cord-292688-w4zvfkyl	242	84	coordinately	coordinately	RB
cord-292688-w4zvfkyl	242	85	with	with	IN
cord-292688-w4zvfkyl	242	86	acidi¢cation	acidi¢cation	NN
cord-292688-w4zvfkyl	242	87	of	of	IN
cord-292688-w4zvfkyl	242	88	maturing	mature	VBG
cord-292688-w4zvfkyl	242	89	secretory	secretory	NN
cord-292688-w4zvfkyl	242	90	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	242	91	Clathrin	Clathrin	NNP
cord-292688-w4zvfkyl	242	92	-	-	HYPH
cord-292688-w4zvfkyl	242	93	coated	coat	VBN
cord-292688-w4zvfkyl	242	94	vesicular	vesicular	JJ
cord-292688-w4zvfkyl	242	95	transport	transport	NN
cord-292688-w4zvfkyl	242	96	of	of	IN
cord-292688-w4zvfkyl	242	97	secretory	secretory	JJ
cord-292688-w4zvfkyl	242	98	proteins	protein	NNS
cord-292688-w4zvfkyl	242	99	during	during	IN
cord-292688-w4zvfkyl	242	100	the	the	DT
cord-292688-w4zvfkyl	242	101	formation	formation	NN
cord-292688-w4zvfkyl	242	102	of	of	IN
cord-292688-w4zvfkyl	242	103	ACTH	ACTH	NNP
cord-292688-w4zvfkyl	242	104	-	-	HYPH
cord-292688-w4zvfkyl	242	105	containing	contain	VBG
cord-292688-w4zvfkyl	242	106	secretory	secretory	JJ
cord-292688-w4zvfkyl	242	107	granules	granule	NNS
cord-292688-w4zvfkyl	242	108	in	in	IN
cord-292688-w4zvfkyl	242	109	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	242	110	cells	cell	NNS
cord-292688-w4zvfkyl	243	1	Chloroquine	Chloroquine	NNP
cord-292688-w4zvfkyl	243	2	diverts	divert	VBZ
cord-292688-w4zvfkyl	243	3	ACTH	ACTH	NNP
cord-292688-w4zvfkyl	243	4	from	from	IN
cord-292688-w4zvfkyl	243	5	a	a	DT
cord-292688-w4zvfkyl	243	6	regulated	regulate	VBN
cord-292688-w4zvfkyl	243	7	to	to	IN
cord-292688-w4zvfkyl	243	8	a	a	DT
cord-292688-w4zvfkyl	243	9	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	243	10	secretory	secretory	JJ
cord-292688-w4zvfkyl	243	11	pathway	pathway	NN
cord-292688-w4zvfkyl	243	12	in	in	IN
cord-292688-w4zvfkyl	243	13	AtT-20	AtT-20	NNP
cord-292688-w4zvfkyl	243	14	cells	cell	NNS
cord-292688-w4zvfkyl	244	1	The	the	DT
cord-292688-w4zvfkyl	244	2	role	role	NN
cord-292688-w4zvfkyl	244	3	of	of	IN
cord-292688-w4zvfkyl	244	4	a	a	DT
cord-292688-w4zvfkyl	244	5	low	low	JJ
cord-292688-w4zvfkyl	244	6	pH	pH	NNP
cord-292688-w4zvfkyl	244	7	intracellular	intracellular	JJ
cord-292688-w4zvfkyl	244	8	compartment	compartment	NN
cord-292688-w4zvfkyl	244	9	in	in	IN
cord-292688-w4zvfkyl	244	10	the	the	DT
cord-292688-w4zvfkyl	244	11	processing	processing	NN
cord-292688-w4zvfkyl	244	12	,	,	,
cord-292688-w4zvfkyl	244	13	storage	storage	NN
cord-292688-w4zvfkyl	244	14	,	,	,
cord-292688-w4zvfkyl	244	15	and	and	CC
cord-292688-w4zvfkyl	244	16	secretion	secretion	NN
cord-292688-w4zvfkyl	244	17	of	of	IN
cord-292688-w4zvfkyl	244	18	ATCH	ATCH	NNP
cord-292688-w4zvfkyl	244	19	and	and	CC
cord-292688-w4zvfkyl	244	20	endorphin	endorphin	NNP
cord-292688-w4zvfkyl	244	21	Transport	Transport	NNP
cord-292688-w4zvfkyl	244	22	via	via	IN
cord-292688-w4zvfkyl	244	23	the	the	DT
cord-292688-w4zvfkyl	244	24	regulated	regulated	JJ
cord-292688-w4zvfkyl	244	25	secretory	secretory	JJ
cord-292688-w4zvfkyl	244	26	pathway	pathway	NN
cord-292688-w4zvfkyl	244	27	in	in	IN
cord-292688-w4zvfkyl	244	28	semi	semi	JJ
cord-292688-w4zvfkyl	244	29	-	-	JJ
cord-292688-w4zvfkyl	244	30	intact	intact	JJ
cord-292688-w4zvfkyl	244	31	PC12	pc12	JJ
cord-292688-w4zvfkyl	244	32	cells	cell	NNS
cord-292688-w4zvfkyl	244	33	:	:	:
cord-292688-w4zvfkyl	244	34	role	role	NN
cord-292688-w4zvfkyl	244	35	of	of	IN
cord-292688-w4zvfkyl	244	36	intra	intra	JJ
cord-292688-w4zvfkyl	244	37	-	-	JJ
cord-292688-w4zvfkyl	244	38	cisternal	cisternal	JJ
cord-292688-w4zvfkyl	244	39	calcium	calcium	NN
cord-292688-w4zvfkyl	244	40	and	and	CC
cord-292688-w4zvfkyl	244	41	pH	ph	NN
cord-292688-w4zvfkyl	244	42	in	in	IN
cord-292688-w4zvfkyl	244	43	the	the	DT
cord-292688-w4zvfkyl	244	44	transport	transport	NN
cord-292688-w4zvfkyl	244	45	and	and	CC
cord-292688-w4zvfkyl	244	46	sorting	sorting	NN
cord-292688-w4zvfkyl	244	47	of	of	IN
cord-292688-w4zvfkyl	244	48	secretogranin	secretogranin	NNS
cord-292688-w4zvfkyl	244	49	II	II	NNP
cord-292688-w4zvfkyl	244	50	Direct	Direct	NNP
cord-292688-w4zvfkyl	244	51	measurement	measurement	NN
cord-292688-w4zvfkyl	244	52	of	of	IN
cord-292688-w4zvfkyl	244	53	trans	trans	NNP
cord-292688-w4zvfkyl	244	54	-	-	NNP
cord-292688-w4zvfkyl	244	55	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	244	56	pH	ph	NN
cord-292688-w4zvfkyl	244	57	in	in	IN
cord-292688-w4zvfkyl	244	58	living	living	NN
cord-292688-w4zvfkyl	244	59	cells	cell	NNS
cord-292688-w4zvfkyl	244	60	and	and	CC
cord-292688-w4zvfkyl	244	61	regulation	regulation	NN
cord-292688-w4zvfkyl	244	62	by	by	IN
cord-292688-w4zvfkyl	244	63	second	second	JJ
cord-292688-w4zvfkyl	244	64	messengers	messenger	NNS
cord-292688-w4zvfkyl	245	1	The	the	DT
cord-292688-w4zvfkyl	245	2	insulin	insulin	NN
cord-292688-w4zvfkyl	245	3	factory	factory	NN
cord-292688-w4zvfkyl	245	4	:	:	:
cord-292688-w4zvfkyl	246	1	a	a	DT
cord-292688-w4zvfkyl	246	2	tour	tour	NN
cord-292688-w4zvfkyl	246	3	of	of	IN
cord-292688-w4zvfkyl	246	4	the	the	DT
cord-292688-w4zvfkyl	246	5	plant	plant	NN
cord-292688-w4zvfkyl	246	6	surroundings	surrounding	NNS
cord-292688-w4zvfkyl	246	7	and	and	CC
cord-292688-w4zvfkyl	246	8	a	a	DT
cord-292688-w4zvfkyl	246	9	visit	visit	NN
cord-292688-w4zvfkyl	246	10	to	to	IN
cord-292688-w4zvfkyl	246	11	the	the	DT
cord-292688-w4zvfkyl	246	12	assembly	assembly	NN
cord-292688-w4zvfkyl	246	13	line	line	NN
cord-292688-w4zvfkyl	246	14	Sorting	sorting	NN
cord-292688-w4zvfkyl	246	15	and	and	CC
cord-292688-w4zvfkyl	246	16	processing	processing	NN
cord-292688-w4zvfkyl	246	17	of	of	IN
cord-292688-w4zvfkyl	246	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	246	19	proteins	protein	NNS
cord-292688-w4zvfkyl	246	20	Prohormone	Prohormone	NNP
cord-292688-w4zvfkyl	246	21	processing	processing	NN
cord-292688-w4zvfkyl	246	22	in	in	IN
cord-292688-w4zvfkyl	246	23	the	the	DT
cord-292688-w4zvfkyl	246	24	trans	trans	NNP
cord-292688-w4zvfkyl	246	25	-	-	NNP
cord-292688-w4zvfkyl	246	26	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	246	27	network	network	NN
cord-292688-w4zvfkyl	246	28	:	:	:
cord-292688-w4zvfkyl	246	29	endoproteolytic	endoproteolytic	JJ
cord-292688-w4zvfkyl	246	30	cleavage	cleavage	NN
cord-292688-w4zvfkyl	246	31	of	of	IN
cord-292688-w4zvfkyl	246	32	prosomatostatin	prosomatostatin	NNS
cord-292688-w4zvfkyl	246	33	and	and	CC
cord-292688-w4zvfkyl	246	34	formation	formation	NN
cord-292688-w4zvfkyl	246	35	of	of	IN
cord-292688-w4zvfkyl	246	36	nascent	nascent	JJ
cord-292688-w4zvfkyl	246	37	secretory	secretory	JJ
cord-292688-w4zvfkyl	246	38	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	246	39	in	in	IN
cord-292688-w4zvfkyl	246	40	permeabilized	permeabilized	JJ
cord-292688-w4zvfkyl	246	41	cells	cell	NNS
cord-292688-w4zvfkyl	246	42	Proteolytic	proteolytic	JJ
cord-292688-w4zvfkyl	246	43	processing	processing	NN
cord-292688-w4zvfkyl	246	44	of	of	IN
cord-292688-w4zvfkyl	246	45	pro	pro	JJ
cord-292688-w4zvfkyl	246	46	-	-	JJ
cord-292688-w4zvfkyl	246	47	ACTH	acth	JJ
cord-292688-w4zvfkyl	246	48	/	/	SYM
cord-292688-w4zvfkyl	246	49	endorphin	endorphin	NN
cord-292688-w4zvfkyl	246	50	begins	begin	VBZ
cord-292688-w4zvfkyl	246	51	in	in	IN
cord-292688-w4zvfkyl	246	52	the	the	DT
cord-292688-w4zvfkyl	246	53	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	246	54	complex	complex	NN
cord-292688-w4zvfkyl	246	55	of	of	IN
cord-292688-w4zvfkyl	246	56	pituitary	pituitary	JJ
cord-292688-w4zvfkyl	246	57	corticotropes	corticotrope	NNS
cord-292688-w4zvfkyl	246	58	and	and	CC
cord-292688-w4zvfkyl	246	59	AtT-20	AtT-20	NNP
cord-292688-w4zvfkyl	246	60	cells	cell	NNS
cord-292688-w4zvfkyl	247	1	Proteolytic	proteolytic	JJ
cord-292688-w4zvfkyl	247	2	maturation	maturation	NN
cord-292688-w4zvfkyl	247	3	of	of	IN
cord-292688-w4zvfkyl	247	4	insulin	insulin	NN
cord-292688-w4zvfkyl	247	5	is	be	VBZ
cord-292688-w4zvfkyl	247	6	a	a	DT
cord-292688-w4zvfkyl	247	7	post	post	JJ
cord-292688-w4zvfkyl	247	8	-	-	JJ
cord-292688-w4zvfkyl	247	9	Golgi	golgi	JJ
cord-292688-w4zvfkyl	247	10	event	event	NN
cord-292688-w4zvfkyl	247	11	which	which	WDT
cord-292688-w4zvfkyl	247	12	occurs	occur	VBZ
cord-292688-w4zvfkyl	247	13	in	in	IN
cord-292688-w4zvfkyl	247	14	acidifying	acidify	VBG
cord-292688-w4zvfkyl	247	15	clathrin	clathrin	NN
cord-292688-w4zvfkyl	247	16	-	-	HYPH
cord-292688-w4zvfkyl	247	17	coated	coat	VBN
cord-292688-w4zvfkyl	247	18	secretory	secretory	NN
cord-292688-w4zvfkyl	247	19	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	248	1	An	an	DT
cord-292688-w4zvfkyl	248	2	antibody	antibody	NN
cord-292688-w4zvfkyl	248	3	speci¢c	speci¢c	NNP
cord-292688-w4zvfkyl	248	4	for	for	IN
cord-292688-w4zvfkyl	248	5	an	an	DT
cord-292688-w4zvfkyl	248	6	endoproteolytic	endoproteolytic	JJ
cord-292688-w4zvfkyl	248	7	cleavage	cleavage	NN
cord-292688-w4zvfkyl	248	8	site	site	NN
cord-292688-w4zvfkyl	248	9	provides	provide	VBZ
cord-292688-w4zvfkyl	248	10	evidence	evidence	NN
cord-292688-w4zvfkyl	248	11	that	that	IN
cord-292688-w4zvfkyl	248	12	pro	pro	JJ
cord-292688-w4zvfkyl	248	13	-	-	JJ
cord-292688-w4zvfkyl	248	14	opiomelanocortin	opiomelanocortin	JJ
cord-292688-w4zvfkyl	248	15	is	be	VBZ
cord-292688-w4zvfkyl	248	16	packaged	package	VBN
cord-292688-w4zvfkyl	248	17	into	into	IN
cord-292688-w4zvfkyl	248	18	secretory	secretory	JJ
cord-292688-w4zvfkyl	248	19	granules	granule	NNS
cord-292688-w4zvfkyl	248	20	in	in	IN
cord-292688-w4zvfkyl	248	21	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	248	22	cells	cell	NNS
cord-292688-w4zvfkyl	248	23	before	before	IN
cord-292688-w4zvfkyl	248	24	its	-PRON-	PRP$
cord-292688-w4zvfkyl	248	25	cleavage	cleavage	NN
cord-292688-w4zvfkyl	248	26	pH	ph	NN
cord-292688-w4zvfkyl	248	27	-	-	HYPH
cord-292688-w4zvfkyl	248	28	dependent	dependent	JJ
cord-292688-w4zvfkyl	248	29	processing	processing	NN
cord-292688-w4zvfkyl	248	30	of	of	IN
cord-292688-w4zvfkyl	248	31	secretogranin	secretogranin	NNP
cord-292688-w4zvfkyl	248	32	II	II	NNP
cord-292688-w4zvfkyl	248	33	by	by	IN
cord-292688-w4zvfkyl	248	34	the	the	DT
cord-292688-w4zvfkyl	248	35	endopeptidase	endopeptidase	NN
cord-292688-w4zvfkyl	248	36	PC2	PC2	NNP
cord-292688-w4zvfkyl	248	37	in	in	IN
cord-292688-w4zvfkyl	248	38	isolated	isolate	VBN
cord-292688-w4zvfkyl	248	39	immature	immature	JJ
cord-292688-w4zvfkyl	248	40	secretory	secretory	JJ
cord-292688-w4zvfkyl	248	41	granules	granule	NNS
cord-292688-w4zvfkyl	248	42	Formation	formation	NN
cord-292688-w4zvfkyl	248	43	of	of	IN
cord-292688-w4zvfkyl	248	44	the	the	DT
cord-292688-w4zvfkyl	248	45	insulin	insulin	NN
cord-292688-w4zvfkyl	248	46	-	-	HYPH
cord-292688-w4zvfkyl	248	47	containing	contain	VBG
cord-292688-w4zvfkyl	248	48	secretory	secretory	JJ
cord-292688-w4zvfkyl	248	49	granule	granule	NN
cord-292688-w4zvfkyl	248	50	core	core	NN
cord-292688-w4zvfkyl	248	51	occurs	occur	VBZ
cord-292688-w4zvfkyl	248	52	within	within	IN
cord-292688-w4zvfkyl	248	53	immature	immature	JJ
cord-292688-w4zvfkyl	248	54	beta	beta	NN
cord-292688-w4zvfkyl	248	55	-	-	HYPH
cord-292688-w4zvfkyl	248	56	granules	granule	NNS
cord-292688-w4zvfkyl	248	57	pH	ph	NN
cord-292688-w4zvfkyl	248	58	-	-	HYPH
cord-292688-w4zvfkyl	248	59	independent	independent	JJ
cord-292688-w4zvfkyl	248	60	and	and	CC
cord-292688-w4zvfkyl	248	61	-dependent	-dependent	JJ
cord-292688-w4zvfkyl	248	62	cleavage	cleavage	NN
cord-292688-w4zvfkyl	248	63	of	of	IN
cord-292688-w4zvfkyl	248	64	proinsulin	proinsulin	NNP
cord-292688-w4zvfkyl	248	65	in	in	IN
cord-292688-w4zvfkyl	248	66	the	the	DT
cord-292688-w4zvfkyl	248	67	same	same	JJ
cord-292688-w4zvfkyl	248	68	secretory	secretory	JJ
cord-292688-w4zvfkyl	248	69	vesicle	vesicle	NN
cord-292688-w4zvfkyl	249	1	Distinct	distinct	JJ
cord-292688-w4zvfkyl	249	2	molecular	molecular	JJ
cord-292688-w4zvfkyl	249	3	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	249	4	for	for	IN
cord-292688-w4zvfkyl	249	5	protein	protein	NN
cord-292688-w4zvfkyl	249	6	sorting	sorting	NN
cord-292688-w4zvfkyl	249	7	within	within	IN
cord-292688-w4zvfkyl	249	8	immature	immature	JJ
cord-292688-w4zvfkyl	249	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	249	10	granules	granule	NNS
cord-292688-w4zvfkyl	249	11	of	of	IN
cord-292688-w4zvfkyl	249	12	pancreatic	pancreatic	JJ
cord-292688-w4zvfkyl	249	13	L	l	NN
cord-292688-w4zvfkyl	249	14	-	-	HYPH
cord-292688-w4zvfkyl	249	15	cells	cell	NNS
cord-292688-w4zvfkyl	249	16	Sorting	sort	VBG
cord-292688-w4zvfkyl	249	17	within	within	IN
cord-292688-w4zvfkyl	249	18	the	the	DT
cord-292688-w4zvfkyl	249	19	regulated	regulate	VBN
cord-292688-w4zvfkyl	249	20	secretory	secretory	JJ
cord-292688-w4zvfkyl	249	21	pathway	pathway	NN
cord-292688-w4zvfkyl	249	22	occurs	occur	VBZ
cord-292688-w4zvfkyl	249	23	in	in	IN
cord-292688-w4zvfkyl	249	24	the	the	DT
cord-292688-w4zvfkyl	249	25	trans	trans	NNP
cord-292688-w4zvfkyl	249	26	-	-	NNP
cord-292688-w4zvfkyl	249	27	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	249	28	network	network	NN
cord-292688-w4zvfkyl	249	29	Cell	cell	NN
cord-292688-w4zvfkyl	249	30	type	type	NN
cord-292688-w4zvfkyl	249	31	-	-	HYPH
cord-292688-w4zvfkyl	249	32	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	249	33	sorting	sorting	NN
cord-292688-w4zvfkyl	249	34	of	of	IN
cord-292688-w4zvfkyl	249	35	neuropeptides	neuropeptide	NNS
cord-292688-w4zvfkyl	249	36	:	:	:
cord-292688-w4zvfkyl	249	37	a	a	DT
cord-292688-w4zvfkyl	249	38	mechanism	mechanism	NN
cord-292688-w4zvfkyl	249	39	to	to	TO
cord-292688-w4zvfkyl	249	40	modulate	modulate	VB
cord-292688-w4zvfkyl	249	41	peptide	peptide	JJ
cord-292688-w4zvfkyl	249	42	composition	composition	NN
cord-292688-w4zvfkyl	249	43	of	of	IN
cord-292688-w4zvfkyl	249	44	large	large	JJ
cord-292688-w4zvfkyl	249	45	dense	dense	JJ
cord-292688-w4zvfkyl	249	46	-	-	HYPH
cord-292688-w4zvfkyl	249	47	core	core	NN
cord-292688-w4zvfkyl	249	48	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	249	49	Constitutive	constitutive	JJ
cord-292688-w4zvfkyl	249	50	and	and	CC
cord-292688-w4zvfkyl	249	51	regulated	regulated	JJ
cord-292688-w4zvfkyl	249	52	secretion	secretion	NN
cord-292688-w4zvfkyl	249	53	of	of	IN
cord-292688-w4zvfkyl	249	54	proteins	protein	NNS
cord-292688-w4zvfkyl	249	55	Di¡er	Di¡er	NNP
cord-292688-w4zvfkyl	249	56	-	-	HYPH
cord-292688-w4zvfkyl	249	57	ential	ential	NN
cord-292688-w4zvfkyl	249	58	sorting	sorting	NN
cord-292688-w4zvfkyl	249	59	of	of	IN
cord-292688-w4zvfkyl	249	60	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	249	61	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	249	62	out	out	IN
cord-292688-w4zvfkyl	249	63	of	of	IN
cord-292688-w4zvfkyl	249	64	the	the	DT
cord-292688-w4zvfkyl	249	65	regulated	regulate	VBN
cord-292688-w4zvfkyl	249	66	secretory	secretory	JJ
cord-292688-w4zvfkyl	249	67	pathway	pathway	NN
cord-292688-w4zvfkyl	249	68	in	in	IN
cord-292688-w4zvfkyl	249	69	pancreatic	pancreatic	JJ
cord-292688-w4zvfkyl	249	70	L	l	NN
cord-292688-w4zvfkyl	249	71	-	-	HYPH
cord-292688-w4zvfkyl	249	72	cells	cell	NNS
cord-292688-w4zvfkyl	249	73	Protein	Protein	NNP
cord-292688-w4zvfkyl	249	74	secretion	secretion	NN
cord-292688-w4zvfkyl	249	75	:	:	:
cord-292688-w4zvfkyl	249	76	puzzling	puzzle	VBG
cord-292688-w4zvfkyl	249	77	receptors	receptor	NNS
cord-292688-w4zvfkyl	249	78	Pathways	pathway	NNS
cord-292688-w4zvfkyl	249	79	of	of	IN
cord-292688-w4zvfkyl	249	80	protein	protein	NN
cord-292688-w4zvfkyl	249	81	secretion	secretion	NN
cord-292688-w4zvfkyl	249	82	in	in	IN
cord-292688-w4zvfkyl	249	83	eukaryotes	eukaryote	NNS
cord-292688-w4zvfkyl	250	1	Identi¢cation	identi¢cation	NN
cord-292688-w4zvfkyl	250	2	of	of	IN
cord-292688-w4zvfkyl	250	3	the	the	DT
cord-292688-w4zvfkyl	250	4	sorting	sorting	NN
cord-292688-w4zvfkyl	250	5	signal	signal	NN
cord-292688-w4zvfkyl	250	6	motif	motif	NN
cord-292688-w4zvfkyl	250	7	within	within	IN
cord-292688-w4zvfkyl	250	8	pro	pro	JJ
cord-292688-w4zvfkyl	250	9	-	-	JJ
cord-292688-w4zvfkyl	250	10	opiomelanocortin	opiomelanocortin	JJ
cord-292688-w4zvfkyl	250	11	for	for	IN
cord-292688-w4zvfkyl	250	12	the	the	DT
cord-292688-w4zvfkyl	250	13	regulated	regulate	VBN
cord-292688-w4zvfkyl	250	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	250	15	pathway	pathway	NN
cord-292688-w4zvfkyl	251	1	The	the	DT
cord-292688-w4zvfkyl	251	2	disul¢de	disul¢de	NNP
cord-292688-w4zvfkyl	251	3	bond	bond	NN
cord-292688-w4zvfkyl	251	4	in	in	IN
cord-292688-w4zvfkyl	251	5	chromogranin	chromogranin	NNP
cord-292688-w4zvfkyl	251	6	B	B	NNP
cord-292688-w4zvfkyl	251	7	,	,	,
cord-292688-w4zvfkyl	251	8	which	which	WDT
cord-292688-w4zvfkyl	251	9	is	be	VBZ
cord-292688-w4zvfkyl	251	10	essential	essential	JJ
cord-292688-w4zvfkyl	251	11	for	for	IN
cord-292688-w4zvfkyl	251	12	its	-PRON-	PRP$
cord-292688-w4zvfkyl	251	13	sorting	sorting	NN
cord-292688-w4zvfkyl	251	14	to	to	IN
cord-292688-w4zvfkyl	251	15	secretory	secretory	JJ
cord-292688-w4zvfkyl	251	16	granules	granule	NNS
cord-292688-w4zvfkyl	251	17	,	,	,
cord-292688-w4zvfkyl	251	18	is	be	VBZ
cord-292688-w4zvfkyl	251	19	not	not	RB
cord-292688-w4zvfkyl	251	20	required	require	VBN
cord-292688-w4zvfkyl	251	21	for	for	IN
cord-292688-w4zvfkyl	251	22	its	-PRON-	PRP$
cord-292688-w4zvfkyl	251	23	aggregation	aggregation	NN
cord-292688-w4zvfkyl	251	24	in	in	IN
cord-292688-w4zvfkyl	251	25	the	the	DT
cord-292688-w4zvfkyl	251	26	trans	trans	NNP
cord-292688-w4zvfkyl	251	27	-	-	NNP
cord-292688-w4zvfkyl	251	28	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	251	29	network	network	NN
cord-292688-w4zvfkyl	251	30	Chromogranin	Chromogranin	NNP
cord-292688-w4zvfkyl	251	31	B	B	NNP
cord-292688-w4zvfkyl	251	32	(	(	-LRB-
cord-292688-w4zvfkyl	251	33	Secretogranin	Secretogranin	NNP
cord-292688-w4zvfkyl	251	34	I	i	CD
cord-292688-w4zvfkyl	251	35	)	)	-RRB-
cord-292688-w4zvfkyl	251	36	,	,	,
cord-292688-w4zvfkyl	251	37	a	a	DT
cord-292688-w4zvfkyl	251	38	secretory	secretory	JJ
cord-292688-w4zvfkyl	251	39	protein	protein	NN
cord-292688-w4zvfkyl	251	40	of	of	IN
cord-292688-w4zvfkyl	251	41	the	the	DT
cord-292688-w4zvfkyl	251	42	regulated	regulated	JJ
cord-292688-w4zvfkyl	251	43	pathway	pathway	NN
cord-292688-w4zvfkyl	251	44	,	,	,
cord-292688-w4zvfkyl	251	45	is	be	VBZ
cord-292688-w4zvfkyl	251	46	also	also	RB
cord-292688-w4zvfkyl	251	47	present	present	JJ
cord-292688-w4zvfkyl	251	48	in	in	IN
cord-292688-w4zvfkyl	251	49	a	a	DT
cord-292688-w4zvfkyl	251	50	tightly	tightly	RB
cord-292688-w4zvfkyl	251	51	membrane	membrane	NN
cord-292688-w4zvfkyl	251	52	-	-	HYPH
cord-292688-w4zvfkyl	251	53	associated	associate	VBN
cord-292688-w4zvfkyl	251	54	form	form	NN
cord-292688-w4zvfkyl	251	55	in	in	IN
cord-292688-w4zvfkyl	251	56	PC12	PC12	NNP
cord-292688-w4zvfkyl	251	57	cells	cell	NNS
cord-292688-w4zvfkyl	252	1	Carboxypeptidase	Carboxypeptidase	NNP
cord-292688-w4zvfkyl	252	2	E	E	NNP
cord-292688-w4zvfkyl	252	3	is	be	VBZ
cord-292688-w4zvfkyl	252	4	a	a	DT
cord-292688-w4zvfkyl	252	5	regulated	regulated	JJ
cord-292688-w4zvfkyl	252	6	secretory	secretory	JJ
cord-292688-w4zvfkyl	252	7	pathway	pathway	NN
cord-292688-w4zvfkyl	252	8	sorting	sorting	NN
cord-292688-w4zvfkyl	252	9	receptor	receptor	NN
cord-292688-w4zvfkyl	252	10	:	:	:
cord-292688-w4zvfkyl	252	11	genetic	genetic	JJ
cord-292688-w4zvfkyl	252	12	obliteration	obliteration	NN
cord-292688-w4zvfkyl	252	13	leads	lead	VBZ
cord-292688-w4zvfkyl	252	14	to	to	IN
cord-292688-w4zvfkyl	252	15	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	252	16	disorders	disorder	NNS
cord-292688-w4zvfkyl	252	17	in	in	IN
cord-292688-w4zvfkyl	252	18	Cpe	Cpe	NNP
cord-292688-w4zvfkyl	252	19	fat	fat	JJ
cord-292688-w4zvfkyl	252	20	mice	mouse	NNS
cord-292688-w4zvfkyl	253	1	Proinsulin	Proinsulin	NNP
cord-292688-w4zvfkyl	253	2	targeting	target	VBG
cord-292688-w4zvfkyl	253	3	to	to	IN
cord-292688-w4zvfkyl	253	4	the	the	DT
cord-292688-w4zvfkyl	253	5	regulated	regulated	JJ
cord-292688-w4zvfkyl	253	6	pathway	pathway	NN
cord-292688-w4zvfkyl	253	7	is	be	VBZ
cord-292688-w4zvfkyl	253	8	not	not	RB
cord-292688-w4zvfkyl	253	9	impaired	impair	VBN
cord-292688-w4zvfkyl	253	10	in	in	IN
cord-292688-w4zvfkyl	253	11	carboxypeptidase	carboxypeptidase	NN
cord-292688-w4zvfkyl	253	12	E	e	NN
cord-292688-w4zvfkyl	253	13	-	-	NN
cord-292688-w4zvfkyl	253	14	de¢cient	de¢cient	JJ
cord-292688-w4zvfkyl	254	1	Cpe	Cpe	NNP
cord-292688-w4zvfkyl	254	2	fat	fat	JJ
cord-292688-w4zvfkyl	255	1	/Cpe	/Cpe	JJS
cord-292688-w4zvfkyl	255	2	fat	fat	JJ
cord-292688-w4zvfkyl	255	3	mice	mouse	NNS
cord-292688-w4zvfkyl	255	4	Hyperinsulinaemia	Hyperinsulinaemia	NNP
cord-292688-w4zvfkyl	255	5	in	in	IN
cord-292688-w4zvfkyl	255	6	obese	obese	JJ
cord-292688-w4zvfkyl	255	7	fat	fat	JJ
cord-292688-w4zvfkyl	255	8	/	/	SYM
cord-292688-w4zvfkyl	255	9	fat	fat	JJ
cord-292688-w4zvfkyl	255	10	mice	mouse	NNS
cord-292688-w4zvfkyl	255	11	associated	associate	VBN
cord-292688-w4zvfkyl	255	12	with	with	IN
cord-292688-w4zvfkyl	255	13	a	a	DT
cord-292688-w4zvfkyl	255	14	carboxypeptidase	carboxypeptidase	NN
cord-292688-w4zvfkyl	255	15	E	e	NN
cord-292688-w4zvfkyl	255	16	mutation	mutation	NN
cord-292688-w4zvfkyl	255	17	which	which	WDT
cord-292688-w4zvfkyl	255	18	reduces	reduce	VBZ
cord-292688-w4zvfkyl	255	19	enzyme	enzyme	NN
cord-292688-w4zvfkyl	255	20	activity	activity	NN
cord-292688-w4zvfkyl	255	21	pH	ph	NN
cord-292688-w4zvfkyl	255	22	-	-	HYPH
cord-292688-w4zvfkyl	255	23	dependent	dependent	JJ
cord-292688-w4zvfkyl	255	24	interaction	interaction	NN
cord-292688-w4zvfkyl	255	25	of	of	IN
cord-292688-w4zvfkyl	255	26	an	an	DT
cord-292688-w4zvfkyl	255	27	intraluminal	intraluminal	JJ
cord-292688-w4zvfkyl	255	28	loop	loop	NN
cord-292688-w4zvfkyl	255	29	of	of	IN
cord-292688-w4zvfkyl	255	30	inositol	inositol	NN
cord-292688-w4zvfkyl	255	31	1,4,5-triphosphate	1,4,5-triphosphate	CD
cord-292688-w4zvfkyl	255	32	receptor	receptor	NN
cord-292688-w4zvfkyl	255	33	with	with	IN
cord-292688-w4zvfkyl	255	34	chromogranin	chromogranin	NNP
cord-292688-w4zvfkyl	256	1	A	a	DT
cord-292688-w4zvfkyl	256	2	pH	ph	JJ
cord-292688-w4zvfkyl	256	3	-	-	HYPH
cord-292688-w4zvfkyl	256	4	dependent	dependent	JJ
cord-292688-w4zvfkyl	256	5	interaction	interaction	NN
cord-292688-w4zvfkyl	256	6	of	of	IN
cord-292688-w4zvfkyl	256	7	chromogranin	chromogranin	NNS
cord-292688-w4zvfkyl	256	8	A	A	NNP
cord-292688-w4zvfkyl	256	9	with	with	IN
cord-292688-w4zvfkyl	256	10	integral	integral	JJ
cord-292688-w4zvfkyl	256	11	membrane	membrane	NN
cord-292688-w4zvfkyl	256	12	proteins	protein	NNS
cord-292688-w4zvfkyl	256	13	of	of	IN
cord-292688-w4zvfkyl	256	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	256	15	vesicle	vesicle	NN
cord-292688-w4zvfkyl	256	16	including	include	VBG
cord-292688-w4zvfkyl	256	17	260-kDa	260-kda	JJ
cord-292688-w4zvfkyl	256	18	protein	protein	NN
cord-292688-w4zvfkyl	256	19	reactive	reactive	JJ
cord-292688-w4zvfkyl	256	20	to	to	IN
cord-292688-w4zvfkyl	256	21	inositol	inositol	NN
cord-292688-w4zvfkyl	256	22	1,4,5-triphosphate	1,4,5-triphosphate	CD
cord-292688-w4zvfkyl	256	23	receptor	receptor	NN
cord-292688-w4zvfkyl	256	24	antibody	antibody	NN
cord-292688-w4zvfkyl	257	1	A	a	DT
cord-292688-w4zvfkyl	257	2	targeting	targeting	JJ
cord-292688-w4zvfkyl	257	3	sequence	sequence	NN
cord-292688-w4zvfkyl	257	4	for	for	IN
cord-292688-w4zvfkyl	257	5	dense	dense	JJ
cord-292688-w4zvfkyl	257	6	secretory	secretory	JJ
cord-292688-w4zvfkyl	257	7	granules	granule	NNS
cord-292688-w4zvfkyl	257	8	resides	reside	VBZ
cord-292688-w4zvfkyl	257	9	in	in	IN
cord-292688-w4zvfkyl	257	10	the	the	DT
cord-292688-w4zvfkyl	257	11	active	active	JJ
cord-292688-w4zvfkyl	257	12	renin	renin	NN
cord-292688-w4zvfkyl	257	13	protein	protein	NN
cord-292688-w4zvfkyl	257	14	moiety	moiety	NN
cord-292688-w4zvfkyl	257	15	of	of	IN
cord-292688-w4zvfkyl	257	16	human	human	JJ
cord-292688-w4zvfkyl	257	17	preprorenin	preprorenin	NN
cord-292688-w4zvfkyl	258	1	The	the	DT
cord-292688-w4zvfkyl	258	2	exocrine	exocrine	JJ
cord-292688-w4zvfkyl	258	3	protein	protein	NN
cord-292688-w4zvfkyl	258	4	trypsinogen	trypsinogen	NNP
cord-292688-w4zvfkyl	258	5	is	be	VBZ
cord-292688-w4zvfkyl	258	6	targeted	target	VBN
cord-292688-w4zvfkyl	258	7	into	into	IN
cord-292688-w4zvfkyl	258	8	the	the	DT
cord-292688-w4zvfkyl	258	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	258	10	granules	granule	NNS
cord-292688-w4zvfkyl	258	11	of	of	IN
cord-292688-w4zvfkyl	258	12	an	an	DT
cord-292688-w4zvfkyl	258	13	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	258	14	cell	cell	NN
cord-292688-w4zvfkyl	258	15	line	line	NN
cord-292688-w4zvfkyl	258	16	:	:	:
cord-292688-w4zvfkyl	258	17	studies	study	NNS
cord-292688-w4zvfkyl	258	18	by	by	IN
cord-292688-w4zvfkyl	258	19	gene	gene	NN
cord-292688-w4zvfkyl	258	20	transfer	transfer	NN
cord-292688-w4zvfkyl	259	1	A	a	DT
cord-292688-w4zvfkyl	259	2	Chimeric	chimeric	JJ
cord-292688-w4zvfkyl	259	3	proinsulin	proinsulin	NN
cord-292688-w4zvfkyl	259	4	-	-	HYPH
cord-292688-w4zvfkyl	259	5	CD5	cd5	NN
cord-292688-w4zvfkyl	259	6	protein	protein	NN
cord-292688-w4zvfkyl	259	7	expressed	express	VBD
cord-292688-w4zvfkyl	259	8	in	in	IN
cord-292688-w4zvfkyl	259	9	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	259	10	cells	cell	NNS
cord-292688-w4zvfkyl	259	11	is	be	VBZ
cord-292688-w4zvfkyl	259	12	directed	direct	VBN
cord-292688-w4zvfkyl	259	13	to	to	IN
cord-292688-w4zvfkyl	259	14	the	the	DT
cord-292688-w4zvfkyl	259	15	cell	cell	NN
cord-292688-w4zvfkyl	259	16	surface	surface	NN
cord-292688-w4zvfkyl	259	17	via	via	IN
cord-292688-w4zvfkyl	259	18	the	the	DT
cord-292688-w4zvfkyl	259	19	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	259	20	pathway	pathway	NN
cord-292688-w4zvfkyl	259	21	Two	two	CD
cord-292688-w4zvfkyl	259	22	distinct	distinct	JJ
cord-292688-w4zvfkyl	259	23	intracellular	intracellular	JJ
cord-292688-w4zvfkyl	259	24	pathways	pathway	NNS
cord-292688-w4zvfkyl	259	25	transport	transport	VBP
cord-292688-w4zvfkyl	259	26	secretory	secretory	NN
cord-292688-w4zvfkyl	259	27	and	and	CC
cord-292688-w4zvfkyl	259	28	membrane	membrane	NN
cord-292688-w4zvfkyl	259	29	glycoproteins	glycoprotein	NNS
cord-292688-w4zvfkyl	259	30	to	to	IN
cord-292688-w4zvfkyl	259	31	the	the	DT
cord-292688-w4zvfkyl	259	32	surface	surface	NN
cord-292688-w4zvfkyl	259	33	of	of	IN
cord-292688-w4zvfkyl	259	34	pituitary	pituitary	JJ
cord-292688-w4zvfkyl	259	35	tumor	tumor	NN
cord-292688-w4zvfkyl	259	36	cells	cell	NNS
cord-292688-w4zvfkyl	259	37	Requirement	Requirement	NNP
cord-292688-w4zvfkyl	259	38	for	for	IN
cord-292688-w4zvfkyl	259	39	GTP	gtp	NN
cord-292688-w4zvfkyl	259	40	hydrolysis	hydrolysis	NN
cord-292688-w4zvfkyl	259	41	in	in	IN
cord-292688-w4zvfkyl	259	42	the	the	DT
cord-292688-w4zvfkyl	259	43	formation	formation	NN
cord-292688-w4zvfkyl	259	44	of	of	IN
cord-292688-w4zvfkyl	259	45	secretory	secretory	JJ
cord-292688-w4zvfkyl	259	46	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	260	1	The	the	DT
cord-292688-w4zvfkyl	260	2	in	in	FW
cord-292688-w4zvfkyl	260	3	vitro	vitro	FW
cord-292688-w4zvfkyl	260	4	generation	generation	NN
cord-292688-w4zvfkyl	260	5	of	of	IN
cord-292688-w4zvfkyl	260	6	post	post	JJ
cord-292688-w4zvfkyl	260	7	-	-	JJ
cord-292688-w4zvfkyl	260	8	Golgi	golgi	JJ
cord-292688-w4zvfkyl	260	9	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	260	10	carrying	carry	VBG
cord-292688-w4zvfkyl	260	11	viral	viral	JJ
cord-292688-w4zvfkyl	260	12	envelope	envelope	NN
cord-292688-w4zvfkyl	260	13	glycoproteins	glycoprotein	NNS
cord-292688-w4zvfkyl	260	14	requires	require	VBZ
cord-292688-w4zvfkyl	260	15	an	an	DT
cord-292688-w4zvfkyl	260	16	ARFlike	arflike	JJ
cord-292688-w4zvfkyl	260	17	GTP	gtp	NN
cord-292688-w4zvfkyl	260	18	-	-	HYPH
cord-292688-w4zvfkyl	260	19	binding	bind	VBG
cord-292688-w4zvfkyl	260	20	protein	protein	NN
cord-292688-w4zvfkyl	260	21	and	and	CC
cord-292688-w4zvfkyl	260	22	a	a	DT
cord-292688-w4zvfkyl	260	23	protein	protein	NN
cord-292688-w4zvfkyl	260	24	kinase	kinase	NN
cord-292688-w4zvfkyl	260	25	C	c	NN
cord-292688-w4zvfkyl	260	26	associated	associate	VBN
cord-292688-w4zvfkyl	260	27	with	with	IN
cord-292688-w4zvfkyl	260	28	the	the	DT
cord-292688-w4zvfkyl	260	29	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	260	30	apparatus	apparatus	NN
cord-292688-w4zvfkyl	260	31	Multiple	multiple	JJ
cord-292688-w4zvfkyl	260	32	trimeric	trimeric	JJ
cord-292688-w4zvfkyl	260	33	G	g	NN
cord-292688-w4zvfkyl	260	34	-	-	HYPH
cord-292688-w4zvfkyl	260	35	proteins	protein	NNS
cord-292688-w4zvfkyl	260	36	on	on	IN
cord-292688-w4zvfkyl	260	37	the	the	DT
cord-292688-w4zvfkyl	260	38	trans	trans	NNP
cord-292688-w4zvfkyl	260	39	-	-	NNP
cord-292688-w4zvfkyl	260	40	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	260	41	network	network	NN
cord-292688-w4zvfkyl	260	42	exert	exert	VBP
cord-292688-w4zvfkyl	260	43	stimulatory	stimulatory	JJ
cord-292688-w4zvfkyl	260	44	and	and	CC
cord-292688-w4zvfkyl	260	45	inhibitory	inhibitory	JJ
cord-292688-w4zvfkyl	260	46	e¡ects	e¡ect	NNS
cord-292688-w4zvfkyl	260	47	on	on	IN
cord-292688-w4zvfkyl	260	48	secretory	secretory	JJ
cord-292688-w4zvfkyl	260	49	vesicle	vesicle	NN
cord-292688-w4zvfkyl	260	50	formation	formation	NN
cord-292688-w4zvfkyl	261	1	An	an	DT
cord-292688-w4zvfkyl	261	2	elevation	elevation	NN
cord-292688-w4zvfkyl	261	3	of	of	IN
cord-292688-w4zvfkyl	261	4	cytosolic	cytosolic	JJ
cord-292688-w4zvfkyl	261	5	protein	protein	NN
cord-292688-w4zvfkyl	261	6	phosphorylation	phosphorylation	NN
cord-292688-w4zvfkyl	261	7	modulates	modulate	VBZ
cord-292688-w4zvfkyl	261	8	trimeric	trimeric	DT
cord-292688-w4zvfkyl	261	9	G	g	NN
cord-292688-w4zvfkyl	261	10	-	-	HYPH
cord-292688-w4zvfkyl	261	11	protein	protein	NN
cord-292688-w4zvfkyl	261	12	regulation	regulation	NN
cord-292688-w4zvfkyl	261	13	of	of	IN
cord-292688-w4zvfkyl	261	14	secretory	secretory	JJ
cord-292688-w4zvfkyl	261	15	vesicle	vesicle	NN
cord-292688-w4zvfkyl	261	16	formation	formation	NN
cord-292688-w4zvfkyl	261	17	from	from	IN
cord-292688-w4zvfkyl	261	18	the	the	DT
cord-292688-w4zvfkyl	261	19	trans	trans	NNP
cord-292688-w4zvfkyl	261	20	-	-	NNP
cord-292688-w4zvfkyl	261	21	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	261	22	network	network	NN
cord-292688-w4zvfkyl	261	23	A	a	DT
cord-292688-w4zvfkyl	261	24	role	role	NN
cord-292688-w4zvfkyl	261	25	for	for	IN
cord-292688-w4zvfkyl	261	26	ADP	adp	NN
cord-292688-w4zvfkyl	261	27	-	-	HYPH
cord-292688-w4zvfkyl	261	28	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	261	29	factor1	factor1	NN
cord-292688-w4zvfkyl	261	30	,	,	,
cord-292688-w4zvfkyl	261	31	but	but	CC
cord-292688-w4zvfkyl	261	32	not	not	RB
cord-292688-w4zvfkyl	261	33	COP	cop	NN
cord-292688-w4zvfkyl	261	34	I	-PRON-	PRP
cord-292688-w4zvfkyl	261	35	,	,	,
cord-292688-w4zvfkyl	261	36	in	in	IN
cord-292688-w4zvfkyl	261	37	secretory	secretory	JJ
cord-292688-w4zvfkyl	261	38	vesicle	vesicle	NN
cord-292688-w4zvfkyl	261	39	biogenesis	biogenesis	NN
cord-292688-w4zvfkyl	261	40	from	from	IN
cord-292688-w4zvfkyl	261	41	the	the	DT
cord-292688-w4zvfkyl	261	42	trans	trans	NNP
cord-292688-w4zvfkyl	261	43	-	-	NNP
cord-292688-w4zvfkyl	261	44	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	261	45	network	network	NN
cord-292688-w4zvfkyl	261	46	ADP	ADP	NNP
cord-292688-w4zvfkyl	261	47	-	-	HYPH
cord-292688-w4zvfkyl	261	48	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	261	49	factor-1	factor-1	NNP
cord-292688-w4zvfkyl	262	1	stimulates	stimulate	VBZ
cord-292688-w4zvfkyl	262	2	formation	formation	NN
cord-292688-w4zvfkyl	262	3	of	of	IN
cord-292688-w4zvfkyl	262	4	nascent	nascent	JJ
cord-292688-w4zvfkyl	262	5	secretory	secretory	JJ
cord-292688-w4zvfkyl	262	6	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	262	7	from	from	IN
cord-292688-w4zvfkyl	262	8	the	the	DT
cord-292688-w4zvfkyl	262	9	trans	trans	NNP
cord-292688-w4zvfkyl	262	10	-	-	NNP
cord-292688-w4zvfkyl	262	11	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	262	12	network	network	NN
cord-292688-w4zvfkyl	262	13	of	of	IN
cord-292688-w4zvfkyl	262	14	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	262	15	cells	cell	NNS
cord-292688-w4zvfkyl	262	16	Intermediates	Intermediates	NNPS
cord-292688-w4zvfkyl	262	17	in	in	IN
cord-292688-w4zvfkyl	262	18	the	the	DT
cord-292688-w4zvfkyl	262	19	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	262	20	and	and	CC
cord-292688-w4zvfkyl	262	21	regulated	regulated	JJ
cord-292688-w4zvfkyl	262	22	secretory	secretory	JJ
cord-292688-w4zvfkyl	262	23	pathways	pathway	NNS
cord-292688-w4zvfkyl	262	24	released	release	VBN
cord-292688-w4zvfkyl	262	25	in	in	IN
cord-292688-w4zvfkyl	262	26	vitro	vitro	FW
cord-292688-w4zvfkyl	262	27	from	from	IN
cord-292688-w4zvfkyl	262	28	semi	semi	JJ
cord-292688-w4zvfkyl	262	29	-	-	JJ
cord-292688-w4zvfkyl	262	30	intact	intact	JJ
cord-292688-w4zvfkyl	262	31	cells	cell	NNS
cord-292688-w4zvfkyl	263	1	Protein	protein	NN
cord-292688-w4zvfkyl	263	2	discharge	discharge	NN
cord-292688-w4zvfkyl	263	3	from	from	IN
cord-292688-w4zvfkyl	263	4	immature	immature	JJ
cord-292688-w4zvfkyl	263	5	secretory	secretory	JJ
cord-292688-w4zvfkyl	263	6	granules	granule	NNS
cord-292688-w4zvfkyl	263	7	displays	display	VBZ
cord-292688-w4zvfkyl	263	8	both	both	CC
cord-292688-w4zvfkyl	263	9	regulated	regulated	JJ
cord-292688-w4zvfkyl	263	10	and	and	CC
cord-292688-w4zvfkyl	263	11	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	263	12	characteristics	characteristic	NNS
cord-292688-w4zvfkyl	264	1	The	the	DT
cord-292688-w4zvfkyl	264	2	trans	trans	NN
cord-292688-w4zvfkyl	264	3	-	-	JJ
cord-292688-w4zvfkyl	264	4	most	most	JJS
cord-292688-w4zvfkyl	264	5	cisternae	cisternae	NN
cord-292688-w4zvfkyl	264	6	of	of	IN
cord-292688-w4zvfkyl	264	7	the	the	DT
cord-292688-w4zvfkyl	264	8	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	264	9	complex	complex	NN
cord-292688-w4zvfkyl	264	10	:	:	:
cord-292688-w4zvfkyl	264	11	a	a	DT
cord-292688-w4zvfkyl	264	12	compartment	compartment	NN
cord-292688-w4zvfkyl	264	13	for	for	IN
cord-292688-w4zvfkyl	264	14	sorting	sorting	NN
cord-292688-w4zvfkyl	264	15	of	of	IN
cord-292688-w4zvfkyl	264	16	secretory	secretory	NN
cord-292688-w4zvfkyl	264	17	and	and	CC
cord-292688-w4zvfkyl	264	18	plasma	plasma	NN
cord-292688-w4zvfkyl	264	19	membrane	membrane	NN
cord-292688-w4zvfkyl	264	20	proteins	protein	NNS
cord-292688-w4zvfkyl	264	21	Sorting	sort	VBG
cord-292688-w4zvfkyl	264	22	of	of	IN
cord-292688-w4zvfkyl	264	23	progeny	progeny	JJ
cord-292688-w4zvfkyl	264	24	coronavirus	coronavirus	NN
cord-292688-w4zvfkyl	264	25	from	from	IN
cord-292688-w4zvfkyl	264	26	condensed	condense	VBN
cord-292688-w4zvfkyl	264	27	secretory	secretory	JJ
cord-292688-w4zvfkyl	264	28	proteins	protein	NNS
cord-292688-w4zvfkyl	264	29	at	at	IN
cord-292688-w4zvfkyl	264	30	the	the	DT
cord-292688-w4zvfkyl	264	31	exit	exit	NN
cord-292688-w4zvfkyl	264	32	from	from	IN
cord-292688-w4zvfkyl	264	33	the	the	DT
cord-292688-w4zvfkyl	264	34	trans	trans	NNP
cord-292688-w4zvfkyl	264	35	-	-	NNP
cord-292688-w4zvfkyl	264	36	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	264	37	network	network	NN
cord-292688-w4zvfkyl	264	38	of	of	IN
cord-292688-w4zvfkyl	264	39	AtT20	AtT20	NNP
cord-292688-w4zvfkyl	264	40	cells	cell	NNS
cord-292688-w4zvfkyl	265	1	Intracellular	Intracellular	NNP
cord-292688-w4zvfkyl	265	2	tra¤cking	tra¤cke	VBG
cord-292688-w4zvfkyl	265	3	of	of	IN
cord-292688-w4zvfkyl	265	4	furin	furin	NN
cord-292688-w4zvfkyl	265	5	is	be	VBZ
cord-292688-w4zvfkyl	265	6	modulated	modulate	VBN
cord-292688-w4zvfkyl	265	7	by	by	IN
cord-292688-w4zvfkyl	265	8	the	the	DT
cord-292688-w4zvfkyl	265	9	phosphorylation	phosphorylation	NN
cord-292688-w4zvfkyl	265	10	state	state	NN
cord-292688-w4zvfkyl	265	11	of	of	IN
cord-292688-w4zvfkyl	265	12	a	a	DT
cord-292688-w4zvfkyl	265	13	casein	casein	NN
cord-292688-w4zvfkyl	265	14	kinase	kinase	NN
cord-292688-w4zvfkyl	265	15	II	ii	CD
cord-292688-w4zvfkyl	265	16	site	site	NN
cord-292688-w4zvfkyl	265	17	in	in	IN
cord-292688-w4zvfkyl	265	18	its	-PRON-	PRP$
cord-292688-w4zvfkyl	265	19	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	265	20	tail	tail	NN
cord-292688-w4zvfkyl	265	21	Two	two	CD
cord-292688-w4zvfkyl	265	22	independent	independent	JJ
cord-292688-w4zvfkyl	265	23	targeting	targeting	NN
cord-292688-w4zvfkyl	265	24	signals	signal	NNS
cord-292688-w4zvfkyl	265	25	in	in	IN
cord-292688-w4zvfkyl	265	26	the	the	DT
cord-292688-w4zvfkyl	265	27	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	265	28	domain	domain	NN
cord-292688-w4zvfkyl	265	29	determine	determine	VBP
cord-292688-w4zvfkyl	265	30	trans	trans	NNP
cord-292688-w4zvfkyl	265	31	-	-	NNP
cord-292688-w4zvfkyl	265	32	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	265	33	network	network	NN
cord-292688-w4zvfkyl	265	34	localization	localization	NN
cord-292688-w4zvfkyl	265	35	and	and	CC
cord-292688-w4zvfkyl	265	36	endosomal	endosomal	NNP
cord-292688-w4zvfkyl	265	37	tra¤cking	tra¤cke	VBG
cord-292688-w4zvfkyl	265	38	of	of	IN
cord-292688-w4zvfkyl	265	39	the	the	DT
cord-292688-w4zvfkyl	265	40	proprotein	proprotein	NNP
cord-292688-w4zvfkyl	265	41	convertase	convertase	NN
cord-292688-w4zvfkyl	265	42	furin	furin	NNP
cord-292688-w4zvfkyl	266	1	An	an	DT
cord-292688-w4zvfkyl	266	2	acidic	acidic	JJ
cord-292688-w4zvfkyl	266	3	sequence	sequence	NN
cord-292688-w4zvfkyl	266	4	within	within	IN
cord-292688-w4zvfkyl	266	5	the	the	DT
cord-292688-w4zvfkyl	266	6	cytoplasmic	cytoplasmic	JJ
cord-292688-w4zvfkyl	266	7	domain	domain	NN
cord-292688-w4zvfkyl	266	8	of	of	IN
cord-292688-w4zvfkyl	266	9	furin	furin	NN
cord-292688-w4zvfkyl	266	10	functions	function	NNS
cord-292688-w4zvfkyl	266	11	as	as	IN
cord-292688-w4zvfkyl	266	12	a	a	DT
cord-292688-w4zvfkyl	266	13	determinant	determinant	NN
cord-292688-w4zvfkyl	266	14	of	of	IN
cord-292688-w4zvfkyl	266	15	trans	trans	JJ
cord-292688-w4zvfkyl	266	16	-	-	NNP
cord-292688-w4zvfkyl	266	17	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	266	18	network	network	NN
cord-292688-w4zvfkyl	266	19	localization	localization	NN
cord-292688-w4zvfkyl	266	20	and	and	CC
cord-292688-w4zvfkyl	266	21	internalization	internalization	NN
cord-292688-w4zvfkyl	266	22	from	from	IN
cord-292688-w4zvfkyl	266	23	the	the	DT
cord-292688-w4zvfkyl	266	24	cell	cell	NN
cord-292688-w4zvfkyl	266	25	surface	surface	NN
cord-292688-w4zvfkyl	266	26	Cysteine	cysteine	NN
cord-292688-w4zvfkyl	266	27	proteinases	proteinase	NNS
cord-292688-w4zvfkyl	266	28	in	in	IN
cord-292688-w4zvfkyl	266	29	Gh4C1	Gh4C1	NNP
cord-292688-w4zvfkyl	266	30	cells	cell	NNS
cord-292688-w4zvfkyl	266	31	,	,	,
cord-292688-w4zvfkyl	266	32	a	a	DT
cord-292688-w4zvfkyl	266	33	rat	rat	NN
cord-292688-w4zvfkyl	266	34	pituitary	pituitary	NN
cord-292688-w4zvfkyl	266	35	tumor	tumor	NN
cord-292688-w4zvfkyl	266	36	cell	cell	NN
cord-292688-w4zvfkyl	266	37	line	line	NN
cord-292688-w4zvfkyl	266	38	,	,	,
cord-292688-w4zvfkyl	266	39	are	be	VBP
cord-292688-w4zvfkyl	266	40	secreted	secrete	VBN
cord-292688-w4zvfkyl	266	41	by	by	IN
cord-292688-w4zvfkyl	266	42	the	the	DT
cord-292688-w4zvfkyl	266	43	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	266	44	and	and	CC
cord-292688-w4zvfkyl	266	45	regulated	regulated	JJ
cord-292688-w4zvfkyl	266	46	secretory	secretory	JJ
cord-292688-w4zvfkyl	266	47	pathways	pathway	NNS
cord-292688-w4zvfkyl	266	48	Mannose	Mannose	NNP
cord-292688-w4zvfkyl	266	49	6-phosphate	6-phosphate	CD
cord-292688-w4zvfkyl	266	50	receptors	receptor	NNS
cord-292688-w4zvfkyl	266	51	in	in	IN
cord-292688-w4zvfkyl	266	52	sorting	sorting	NN
cord-292688-w4zvfkyl	266	53	and	and	CC
cord-292688-w4zvfkyl	266	54	transport	transport	NN
cord-292688-w4zvfkyl	266	55	of	of	IN
cord-292688-w4zvfkyl	266	56	lysosomal	lysosomal	JJ
cord-292688-w4zvfkyl	266	57	enzymes	enzyme	NNS
cord-292688-w4zvfkyl	267	1	The	the	DT
cord-292688-w4zvfkyl	267	2	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	267	3	adaptor	adaptor	NN
cord-292688-w4zvfkyl	267	4	complex	complex	NN
cord-292688-w4zvfkyl	267	5	binds	bind	VBZ
cord-292688-w4zvfkyl	267	6	to	to	IN
cord-292688-w4zvfkyl	267	7	immature	immature	JJ
cord-292688-w4zvfkyl	267	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	267	9	granules	granule	NNS
cord-292688-w4zvfkyl	267	10	from	from	IN
cord-292688-w4zvfkyl	267	11	PC12	pc12	JJ
cord-292688-w4zvfkyl	267	12	cells	cell	NNS
cord-292688-w4zvfkyl	267	13	,	,	,
cord-292688-w4zvfkyl	267	14	and	and	CC
cord-292688-w4zvfkyl	267	15	is	be	VBZ
cord-292688-w4zvfkyl	267	16	regulated	regulate	VBN
cord-292688-w4zvfkyl	267	17	by	by	IN
cord-292688-w4zvfkyl	267	18	ADP	ADP	NNP
cord-292688-w4zvfkyl	267	19	-	-	HYPH
cord-292688-w4zvfkyl	267	20	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	267	21	factor	factor	NN
cord-292688-w4zvfkyl	267	22	Interaction	Interaction	NNP
cord-292688-w4zvfkyl	267	23	of	of	IN
cord-292688-w4zvfkyl	267	24	furin	furin	NN
cord-292688-w4zvfkyl	267	25	in	in	IN
cord-292688-w4zvfkyl	267	26	immature	immature	JJ
cord-292688-w4zvfkyl	267	27	secretory	secretory	JJ
cord-292688-w4zvfkyl	267	28	granules	granule	NNS
cord-292688-w4zvfkyl	267	29	from	from	IN
cord-292688-w4zvfkyl	267	30	neuroendocrine	neuroendocrine	JJ
cord-292688-w4zvfkyl	267	31	cells	cell	NNS
cord-292688-w4zvfkyl	267	32	with	with	IN
cord-292688-w4zvfkyl	267	33	the	the	DT
cord-292688-w4zvfkyl	267	34	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	267	35	adaptor	adaptor	NN
cord-292688-w4zvfkyl	267	36	complex	complex	NN
cord-292688-w4zvfkyl	267	37	is	be	VBZ
cord-292688-w4zvfkyl	267	38	modulated	modulate	VBN
cord-292688-w4zvfkyl	267	39	by	by	IN
cord-292688-w4zvfkyl	267	40	casein	casein	NN
cord-292688-w4zvfkyl	267	41	kinase	kinase	NN
cord-292688-w4zvfkyl	267	42	II	II	NNP
cord-292688-w4zvfkyl	268	1	phosphorylation	phosphorylation	NN
cord-292688-w4zvfkyl	268	2	Protein	Protein	NNP
cord-292688-w4zvfkyl	268	3	targeting	target	VBG
cord-292688-w4zvfkyl	268	4	via	via	IN
cord-292688-w4zvfkyl	268	5	the`constitutive	the`constitutive	NNP
cord-292688-w4zvfkyl	268	6	-	-	HYPH
cord-292688-w4zvfkyl	268	7	like	like	JJ
cord-292688-w4zvfkyl	268	8	'	'	``
cord-292688-w4zvfkyl	268	9	secretory	secretory	JJ
cord-292688-w4zvfkyl	268	10	pathway	pathway	NN
cord-292688-w4zvfkyl	268	11	in	in	IN
cord-292688-w4zvfkyl	268	12	isolated	isolate	VBN
cord-292688-w4zvfkyl	268	13	pancreatic	pancreatic	JJ
cord-292688-w4zvfkyl	268	14	islets	islet	NNS
cord-292688-w4zvfkyl	268	15	:	:	:
cord-292688-w4zvfkyl	268	16	passive	passive	JJ
cord-292688-w4zvfkyl	268	17	sorting	sorting	NN
cord-292688-w4zvfkyl	268	18	in	in	IN
cord-292688-w4zvfkyl	268	19	the	the	DT
cord-292688-w4zvfkyl	268	20	immature	immature	JJ
cord-292688-w4zvfkyl	268	21	granule	granule	NN
cord-292688-w4zvfkyl	268	22	compartment	compartment	NN
cord-292688-w4zvfkyl	268	23	Biosynthetic	biosynthetic	JJ
cord-292688-w4zvfkyl	268	24	protein	protein	NN
cord-292688-w4zvfkyl	268	25	transport	transport	NN
cord-292688-w4zvfkyl	268	26	and	and	CC
cord-292688-w4zvfkyl	268	27	sorting	sorting	NN
cord-292688-w4zvfkyl	268	28	by	by	IN
cord-292688-w4zvfkyl	268	29	endoplasmic	endoplasmic	NN
cord-292688-w4zvfkyl	268	30	reticulum	reticulum	NN
cord-292688-w4zvfkyl	268	31	HVEM	HVEM	NNP
cord-292688-w4zvfkyl	268	32	tomography	tomography	NN
cord-292688-w4zvfkyl	268	33	of	of	IN
cord-292688-w4zvfkyl	268	34	the	the	DT
cord-292688-w4zvfkyl	268	35	trans	trans	NNP
cord-292688-w4zvfkyl	268	36	-	-	NNP
cord-292688-w4zvfkyl	268	37	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	268	38	network	network	NN
cord-292688-w4zvfkyl	268	39	:	:	:
cord-292688-w4zvfkyl	268	40	structural	structural	JJ
cord-292688-w4zvfkyl	268	41	insights	insight	NNS
cord-292688-w4zvfkyl	268	42	and	and	CC
cord-292688-w4zvfkyl	268	43	identi¢cation	identi¢cation	NN
cord-292688-w4zvfkyl	268	44	of	of	IN
cord-292688-w4zvfkyl	268	45	a	a	DT
cord-292688-w4zvfkyl	268	46	lace	lace	NN
cord-292688-w4zvfkyl	268	47	-	-	HYPH
cord-292688-w4zvfkyl	268	48	like	like	JJ
cord-292688-w4zvfkyl	268	49	vesicle	vesicle	NN
cord-292688-w4zvfkyl	268	50	coat	coat	NN
cord-292688-w4zvfkyl	268	51	A	a	DT
cord-292688-w4zvfkyl	268	52	cytosolic	cytosolic	JJ
cord-292688-w4zvfkyl	268	53	complex	complex	NN
cord-292688-w4zvfkyl	268	54	of	of	IN
cord-292688-w4zvfkyl	268	55	p62	p62	NN
cord-292688-w4zvfkyl	268	56	and	and	CC
cord-292688-w4zvfkyl	268	57	rab6	rab6	NNP
cord-292688-w4zvfkyl	268	58	associates	associate	NNS
cord-292688-w4zvfkyl	268	59	with	with	IN
cord-292688-w4zvfkyl	268	60	TGN38/41	TGN38/41	NNP
cord-292688-w4zvfkyl	268	61	and	and	CC
cord-292688-w4zvfkyl	268	62	is	be	VBZ
cord-292688-w4zvfkyl	268	63	involved	involve	VBN
cord-292688-w4zvfkyl	268	64	in	in	IN
cord-292688-w4zvfkyl	268	65	budding	bud	VBG
cord-292688-w4zvfkyl	268	66	of	of	IN
cord-292688-w4zvfkyl	268	67	exocytic	exocytic	JJ
cord-292688-w4zvfkyl	268	68	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	268	69	from	from	IN
cord-292688-w4zvfkyl	268	70	the	the	DT
cord-292688-w4zvfkyl	268	71	trans	trans	NNP
cord-292688-w4zvfkyl	268	72	-	-	NNP
cord-292688-w4zvfkyl	268	73	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	268	74	network	network	NN
cord-292688-w4zvfkyl	268	75	Distinct	Distinct	NNP
cord-292688-w4zvfkyl	268	76	coated	coat	VBN
cord-292688-w4zvfkyl	268	77	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	268	78	labeled	label	VBN
cord-292688-w4zvfkyl	268	79	for	for	IN
cord-292688-w4zvfkyl	268	80	p200	p200	NN
cord-292688-w4zvfkyl	268	81	bud	bud	NN
cord-292688-w4zvfkyl	268	82	from	from	IN
cord-292688-w4zvfkyl	268	83	trans	trans	NNP
cord-292688-w4zvfkyl	268	84	-	-	NNP
cord-292688-w4zvfkyl	268	85	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	268	86	network	network	NN
cord-292688-w4zvfkyl	268	87	membranes	membrane	NNS
cord-292688-w4zvfkyl	268	88	Perrelet	Perrelet	NNP
cord-292688-w4zvfkyl	268	89	,	,	,
cord-292688-w4zvfkyl	268	90	Clathrin	Clathrin	NNP
cord-292688-w4zvfkyl	268	91	-	-	HYPH
cord-292688-w4zvfkyl	268	92	immunoreactive	immunoreactive	JJ
cord-292688-w4zvfkyl	268	93	sites	site	NNS
cord-292688-w4zvfkyl	268	94	in	in	IN
cord-292688-w4zvfkyl	268	95	the	the	DT
cord-292688-w4zvfkyl	268	96	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	268	97	apparatus	apparatus	NN
cord-292688-w4zvfkyl	268	98	are	be	VBP
cord-292688-w4zvfkyl	268	99	concentrated	concentrate	VBN
cord-292688-w4zvfkyl	268	100	at	at	IN
cord-292688-w4zvfkyl	268	101	the	the	DT
cord-292688-w4zvfkyl	268	102	trans	trans	NNP
cord-292688-w4zvfkyl	268	103	pole	pole	NN
cord-292688-w4zvfkyl	268	104	in	in	IN
cord-292688-w4zvfkyl	268	105	polypeptide	polypeptide	JJ
cord-292688-w4zvfkyl	268	106	hormone	hormone	NN
cord-292688-w4zvfkyl	268	107	-	-	HYPH
cord-292688-w4zvfkyl	268	108	secreting	secrete	VBG
cord-292688-w4zvfkyl	268	109	cells	cell	NNS
cord-292688-w4zvfkyl	268	110	Cell	cell	NN
cord-292688-w4zvfkyl	268	111	-	-	HYPH
cord-292688-w4zvfkyl	268	112	free	free	JJ
cord-292688-w4zvfkyl	268	113	protein	protein	NN
cord-292688-w4zvfkyl	268	114	sorting	sort	VBG
cord-292688-w4zvfkyl	268	115	to	to	IN
cord-292688-w4zvfkyl	268	116	the	the	DT
cord-292688-w4zvfkyl	268	117	regulated	regulated	JJ
cord-292688-w4zvfkyl	268	118	and	and	CC
cord-292688-w4zvfkyl	268	119	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	268	120	secretory	secretory	JJ
cord-292688-w4zvfkyl	268	121	pathways	pathway	NNS
cord-292688-w4zvfkyl	269	1	Trimeric	Trimeric	NNP
cord-292688-w4zvfkyl	269	2	G	g	NN
cord-292688-w4zvfkyl	269	3	proteins	protein	NNS
cord-292688-w4zvfkyl	269	4	and	and	CC
cord-292688-w4zvfkyl	269	5	vesicle	vesicle	NN
cord-292688-w4zvfkyl	269	6	formation	formation	NN
cord-292688-w4zvfkyl	269	7	Formation	formation	NN
cord-292688-w4zvfkyl	269	8	of	of	IN
cord-292688-w4zvfkyl	269	9	nascent	nascent	JJ
cord-292688-w4zvfkyl	269	10	secretory	secretory	JJ
cord-292688-w4zvfkyl	269	11	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	269	12	from	from	IN
cord-292688-w4zvfkyl	269	13	the	the	DT
cord-292688-w4zvfkyl	269	14	trans	trans	NNP
cord-292688-w4zvfkyl	269	15	-	-	NNP
cord-292688-w4zvfkyl	269	16	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	269	17	network	network	NN
cord-292688-w4zvfkyl	269	18	of	of	IN
cord-292688-w4zvfkyl	269	19	endocrine	endocrine	JJ
cord-292688-w4zvfkyl	269	20	cells	cell	NNS
cord-292688-w4zvfkyl	269	21	is	be	VBZ
cord-292688-w4zvfkyl	269	22	inhibited	inhibit	VBN
cord-292688-w4zvfkyl	269	23	by	by	IN
cord-292688-w4zvfkyl	269	24	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	269	25	kinase	kinase	NN
cord-292688-w4zvfkyl	269	26	and	and	CC
cord-292688-w4zvfkyl	269	27	phosphatase	phosphatase	NN
cord-292688-w4zvfkyl	269	28	inhibitors	inhibitor	NNS
cord-292688-w4zvfkyl	270	1	Regulated	regulate	VBN
cord-292688-w4zvfkyl	270	2	formation	formation	NN
cord-292688-w4zvfkyl	270	3	of	of	IN
cord-292688-w4zvfkyl	270	4	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	270	5	secretory	secretory	NN
cord-292688-w4zvfkyl	270	6	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	270	7	containing	contain	VBG
cord-292688-w4zvfkyl	270	8	Alzheimer	Alzheimer	NNP
cord-292688-w4zvfkyl	270	9	beta	beta	JJ
cord-292688-w4zvfkyl	270	10	-	-	HYPH
cord-292688-w4zvfkyl	270	11	amyloid	amyloid	NN
cord-292688-w4zvfkyl	270	12	precursor	precursor	NN
cord-292688-w4zvfkyl	270	13	protein	protein	NN
cord-292688-w4zvfkyl	270	14	Metabolism	metabolism	NN
cord-292688-w4zvfkyl	270	15	of	of	IN
cord-292688-w4zvfkyl	270	16	Alzheimer	Alzheimer	NNP
cord-292688-w4zvfkyl	270	17	beta	beta	NN
cord-292688-w4zvfkyl	270	18	-	-	HYPH
cord-292688-w4zvfkyl	270	19	amyloid	amyloid	NN
cord-292688-w4zvfkyl	270	20	precursor	precursor	NN
cord-292688-w4zvfkyl	270	21	protein	protein	NN
cord-292688-w4zvfkyl	270	22	:	:	:
cord-292688-w4zvfkyl	270	23	regulation	regulation	NN
cord-292688-w4zvfkyl	270	24	by	by	IN
cord-292688-w4zvfkyl	270	25	protein	protein	NN
cord-292688-w4zvfkyl	270	26	kinase	kinase	NN
cord-292688-w4zvfkyl	270	27	A	a	NN
cord-292688-w4zvfkyl	270	28	in	in	IN
cord-292688-w4zvfkyl	270	29	intact	intact	JJ
cord-292688-w4zvfkyl	270	30	cells	cell	NNS
cord-292688-w4zvfkyl	270	31	and	and	CC
cord-292688-w4zvfkyl	270	32	in	in	IN
cord-292688-w4zvfkyl	270	33	a	a	DT
cord-292688-w4zvfkyl	270	34	cell	cell	NN
cord-292688-w4zvfkyl	270	35	-	-	HYPH
cord-292688-w4zvfkyl	270	36	free	free	JJ
cord-292688-w4zvfkyl	270	37	system	system	NN
cord-292688-w4zvfkyl	270	38	ICA	ICA	NNP
cord-292688-w4zvfkyl	270	39	512	512	CD
cord-292688-w4zvfkyl	270	40	,	,	,
cord-292688-w4zvfkyl	270	41	an	an	DT
cord-292688-w4zvfkyl	270	42	autoantigen	autoantigen	NN
cord-292688-w4zvfkyl	270	43	of	of	IN
cord-292688-w4zvfkyl	270	44	type	type	NN
cord-292688-w4zvfkyl	270	45	I	-PRON-	PRP
cord-292688-w4zvfkyl	270	46	diabetes	diabete	VBZ
cord-292688-w4zvfkyl	270	47	,	,	,
cord-292688-w4zvfkyl	270	48	is	be	VBZ
cord-292688-w4zvfkyl	270	49	an	an	DT
cord-292688-w4zvfkyl	270	50	intrinsic	intrinsic	JJ
cord-292688-w4zvfkyl	270	51	membrane	membrane	NN
cord-292688-w4zvfkyl	270	52	protein	protein	NN
cord-292688-w4zvfkyl	270	53	of	of	IN
cord-292688-w4zvfkyl	270	54	neurosecretory	neurosecretory	NNP
cord-292688-w4zvfkyl	270	55	granules	granule	VBZ
cord-292688-w4zvfkyl	270	56	Molecular	molecular	JJ
cord-292688-w4zvfkyl	270	57	cloning	cloning	NN
cord-292688-w4zvfkyl	270	58	of	of	IN
cord-292688-w4zvfkyl	270	59	phogrin	phogrin	NNP
cord-292688-w4zvfkyl	270	60	,	,	,
cord-292688-w4zvfkyl	270	61	a	a	DT
cord-292688-w4zvfkyl	270	62	protein	protein	NN
cord-292688-w4zvfkyl	270	63	-	-	HYPH
cord-292688-w4zvfkyl	270	64	tyrosine	tyrosine	NN
cord-292688-w4zvfkyl	270	65	phosphatase	phosphatase	NN
cord-292688-w4zvfkyl	270	66	homologue	homologue	NN
cord-292688-w4zvfkyl	270	67	localized	localize	VBN
cord-292688-w4zvfkyl	270	68	to	to	IN
cord-292688-w4zvfkyl	270	69	insulin	insulin	NN
cord-292688-w4zvfkyl	270	70	secretory	secretory	JJ
cord-292688-w4zvfkyl	270	71	granule	granule	NN
cord-292688-w4zvfkyl	270	72	membranes	membrane	NNS
cord-292688-w4zvfkyl	271	1	The	the	DT
cord-292688-w4zvfkyl	271	2	binding	binding	NN
cord-292688-w4zvfkyl	271	3	of	of	IN
cord-292688-w4zvfkyl	271	4	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	271	5	clathrin	clathrin	NN
cord-292688-w4zvfkyl	271	6	adaptor	adaptor	NN
cord-292688-w4zvfkyl	271	7	particles	particle	NNS
cord-292688-w4zvfkyl	271	8	to	to	IN
cord-292688-w4zvfkyl	271	9	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	271	10	membranes	membrane	NNS
cord-292688-w4zvfkyl	271	11	requires	require	VBZ
cord-292688-w4zvfkyl	271	12	ADP	adp	NN
cord-292688-w4zvfkyl	271	13	-	-	HYPH
cord-292688-w4zvfkyl	271	14	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	271	15	factor	factor	NN
cord-292688-w4zvfkyl	271	16	,	,	,
cord-292688-w4zvfkyl	271	17	a	a	DT
cord-292688-w4zvfkyl	271	18	small	small	JJ
cord-292688-w4zvfkyl	271	19	GTP	gtp	NN
cord-292688-w4zvfkyl	271	20	-	-	HYPH
cord-292688-w4zvfkyl	271	21	binding	bind	VBG
cord-292688-w4zvfkyl	271	22	protein	protein	NN
cord-292688-w4zvfkyl	271	23	Mannose	Mannose	NNP
cord-292688-w4zvfkyl	271	24	6-phosphate	6-phosphate	NNP
cord-292688-w4zvfkyl	271	25	receptors	receptor	NNS
cord-292688-w4zvfkyl	271	26	and	and	CC
cord-292688-w4zvfkyl	271	27	ADP	adp	NN
cord-292688-w4zvfkyl	271	28	-	-	HYPH
cord-292688-w4zvfkyl	271	29	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	271	30	factors	factor	NNS
cord-292688-w4zvfkyl	271	31	cooperate	cooperate	VBP
cord-292688-w4zvfkyl	271	32	for	for	IN
cord-292688-w4zvfkyl	271	33	high	high	JJ
cord-292688-w4zvfkyl	271	34	a¤nity	a¤nity	NN
cord-292688-w4zvfkyl	271	35	interaction	interaction	NN
cord-292688-w4zvfkyl	271	36	of	of	IN
cord-292688-w4zvfkyl	271	37	the	the	DT
cord-292688-w4zvfkyl	271	38	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	271	39	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	271	40	assembly	assembly	NN
cord-292688-w4zvfkyl	271	41	proteins	protein	NNS
cord-292688-w4zvfkyl	271	42	with	with	IN
cord-292688-w4zvfkyl	271	43	membranes	membrane	NNS
cord-292688-w4zvfkyl	271	44	ADP	adp	NN
cord-292688-w4zvfkyl	271	45	-	-	HYPH
cord-292688-w4zvfkyl	271	46	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	271	47	factor	factor	NN
cord-292688-w4zvfkyl	271	48	,	,	,
cord-292688-w4zvfkyl	271	49	a	a	DT
cord-292688-w4zvfkyl	271	50	small	small	JJ
cord-292688-w4zvfkyl	271	51	GTP	gtp	NN
cord-292688-w4zvfkyl	271	52	-	-	HYPH
cord-292688-w4zvfkyl	271	53	dependent	dependent	JJ
cord-292688-w4zvfkyl	271	54	regulatory	regulatory	JJ
cord-292688-w4zvfkyl	271	55	protein	protein	NN
cord-292688-w4zvfkyl	271	56	,	,	,
cord-292688-w4zvfkyl	271	57	stimulates	stimulate	VBZ
cord-292688-w4zvfkyl	271	58	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	271	59	D	d	NN
cord-292688-w4zvfkyl	271	60	activity	activity	NN
cord-292688-w4zvfkyl	271	61	Phospholipase	Phospholipase	NNP
cord-292688-w4zvfkyl	271	62	D	D	NNP
cord-292688-w4zvfkyl	271	63	:	:	:
cord-292688-w4zvfkyl	271	64	a	a	DT
cord-292688-w4zvfkyl	271	65	downstream	downstream	JJ
cord-292688-w4zvfkyl	271	66	e¡ector	e¡ector	NN
cord-292688-w4zvfkyl	271	67	of	of	IN
cord-292688-w4zvfkyl	271	68	ARF	arf	NN
cord-292688-w4zvfkyl	271	69	in	in	IN
cord-292688-w4zvfkyl	271	70	granulocytes	granulocyte	VBZ
cord-292688-w4zvfkyl	271	71	Human	Human	NNP
cord-292688-w4zvfkyl	271	72	ADP	ADP	NNP
cord-292688-w4zvfkyl	271	73	-	-	HYPH
cord-292688-w4zvfkyl	271	74	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	271	75	factor	factor	NN
cord-292688-w4zvfkyl	271	76	-	-	HYPH
cord-292688-w4zvfkyl	271	77	activated	activate	VBN
cord-292688-w4zvfkyl	271	78	phosphatidylcholine	phosphatidylcholine	NN
cord-292688-w4zvfkyl	271	79	-	-	HYPH
cord-292688-w4zvfkyl	271	80	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	271	81	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	271	82	D	D	NNP
cord-292688-w4zvfkyl	271	83	de¢nes	de¢nes	NNPS
cord-292688-w4zvfkyl	271	84	a	a	DT
cord-292688-w4zvfkyl	271	85	new	new	JJ
cord-292688-w4zvfkyl	271	86	and	and	CC
cord-292688-w4zvfkyl	271	87	highly	highly	RB
cord-292688-w4zvfkyl	271	88	conserved	conserved	JJ
cord-292688-w4zvfkyl	271	89	gene	gene	NN
cord-292688-w4zvfkyl	271	90	family	family	NN
cord-292688-w4zvfkyl	271	91	Arf	Arf	NNP
cord-292688-w4zvfkyl	271	92	proteins	protein	NNS
cord-292688-w4zvfkyl	271	93	:	:	:
cord-292688-w4zvfkyl	272	1	the	the	DT
cord-292688-w4zvfkyl	272	2	membrane	membrane	NN
cord-292688-w4zvfkyl	272	3	tra¤c	tra¤c	NNP
cord-292688-w4zvfkyl	272	4	police	police	NNS
cord-292688-w4zvfkyl	272	5	?	?	.
cord-292688-w4zvfkyl	273	1	Phospholipase	Phospholipase	NNP
cord-292688-w4zvfkyl	273	2	D	d	NN
cord-292688-w4zvfkyl	273	3	stimulates	stimulate	VBZ
cord-292688-w4zvfkyl	273	4	release	release	NN
cord-292688-w4zvfkyl	273	5	of	of	IN
cord-292688-w4zvfkyl	273	6	nascent	nascent	JJ
cord-292688-w4zvfkyl	273	7	secretory	secretory	JJ
cord-292688-w4zvfkyl	273	8	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	273	9	from	from	IN
cord-292688-w4zvfkyl	273	10	the	the	DT
cord-292688-w4zvfkyl	273	11	trans	trans	NNP
cord-292688-w4zvfkyl	273	12	-	-	NNP
cord-292688-w4zvfkyl	273	13	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	273	14	network	network	NN
cord-292688-w4zvfkyl	274	1	The	the	DT
cord-292688-w4zvfkyl	274	2	role	role	NN
cord-292688-w4zvfkyl	274	3	of	of	IN
cord-292688-w4zvfkyl	274	4	ADPribosylation	adpribosylation	NN
cord-292688-w4zvfkyl	274	5	factor	factor	NN
cord-292688-w4zvfkyl	274	6	and	and	CC
cord-292688-w4zvfkyl	274	7	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	274	8	D	d	NN
cord-292688-w4zvfkyl	274	9	in	in	IN
cord-292688-w4zvfkyl	274	10	adaptor	adaptor	NN
cord-292688-w4zvfkyl	274	11	recruitment	recruitment	NN
cord-292688-w4zvfkyl	274	12	Type	type	NN
cord-292688-w4zvfkyl	274	13	I	-PRON-	PRP
cord-292688-w4zvfkyl	274	14	phosphatidylinositol	phosphatidylinositol	VBP
cord-292688-w4zvfkyl	274	15	4-phosphate	4-phosphate	CD
cord-292688-w4zvfkyl	274	16	5-kinase	5-kinase	CD
cord-292688-w4zvfkyl	274	17	isoforms	isoform	NNS
cord-292688-w4zvfkyl	274	18	are	be	VBP
cord-292688-w4zvfkyl	274	19	speci¢cally	speci¢cally	RB
cord-292688-w4zvfkyl	274	20	stimulated	stimulate	VBN
cord-292688-w4zvfkyl	274	21	by	by	IN
cord-292688-w4zvfkyl	274	22	phosphatidic	phosphatidic	JJ
cord-292688-w4zvfkyl	274	23	acid	acid	NN
cord-292688-w4zvfkyl	274	24	Phosphoinositides	Phosphoinositides	NNPS
cord-292688-w4zvfkyl	274	25	as	as	IN
cord-292688-w4zvfkyl	274	26	regulators	regulator	NNS
cord-292688-w4zvfkyl	274	27	in	in	IN
cord-292688-w4zvfkyl	274	28	membrane	membrane	NN
cord-292688-w4zvfkyl	274	29	tra¤c	tra¤c	NNP
cord-292688-w4zvfkyl	274	30	E¡ects	e¡ect	NNS
cord-292688-w4zvfkyl	274	31	of	of	IN
cord-292688-w4zvfkyl	274	32	acid	acid	JJ
cord-292688-w4zvfkyl	274	33	phospholipids	phospholipid	NNS
cord-292688-w4zvfkyl	274	34	on	on	IN
cord-292688-w4zvfkyl	274	35	nucleotide	nucleotide	JJ
cord-292688-w4zvfkyl	274	36	exchange	exchange	NN
cord-292688-w4zvfkyl	274	37	properties	property	NNS
cord-292688-w4zvfkyl	274	38	of	of	IN
cord-292688-w4zvfkyl	274	39	ADP	ADP	NNP
cord-292688-w4zvfkyl	274	40	-	-	HYPH
cord-292688-w4zvfkyl	274	41	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	274	42	factor	factor	NN
cord-292688-w4zvfkyl	274	43	1	1	CD
cord-292688-w4zvfkyl	274	44	.	.	.
cord-292688-w4zvfkyl	275	1	Evidence	evidence	NN
cord-292688-w4zvfkyl	275	2	for	for	IN
cord-292688-w4zvfkyl	275	3	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	275	4	interaction	interaction	NN
cord-292688-w4zvfkyl	275	5	with	with	IN
cord-292688-w4zvfkyl	275	6	phosphatidylinositol	phosphatidylinositol	JJ
cord-292688-w4zvfkyl	275	7	4,5-bisphosphate	4,5-bisphosphate	CD
cord-292688-w4zvfkyl	275	8	GTP	gtp	NN
cord-292688-w4zvfkyl	275	9	hydrolysis	hydrolysis	NN
cord-292688-w4zvfkyl	275	10	by	by	IN
cord-292688-w4zvfkyl	275	11	ADP	adp	NN
cord-292688-w4zvfkyl	275	12	-	-	HYPH
cord-292688-w4zvfkyl	275	13	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	275	14	factor	factor	NN
cord-292688-w4zvfkyl	275	15	is	be	VBZ
cord-292688-w4zvfkyl	275	16	dependent	dependent	JJ
cord-292688-w4zvfkyl	275	17	on	on	IN
cord-292688-w4zvfkyl	275	18	both	both	CC
cord-292688-w4zvfkyl	275	19	an	an	DT
cord-292688-w4zvfkyl	275	20	ADP	ADP	NNP
cord-292688-w4zvfkyl	275	21	-	-	HYPH
cord-292688-w4zvfkyl	275	22	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	275	23	factor	factor	NN
cord-292688-w4zvfkyl	275	24	GTPase	GTPase	NNP
cord-292688-w4zvfkyl	275	25	-	-	HYPH
cord-292688-w4zvfkyl	275	26	activating	activate	VBG
cord-292688-w4zvfkyl	275	27	protein	protein	NN
cord-292688-w4zvfkyl	275	28	and	and	CC
cord-292688-w4zvfkyl	275	29	acid	acid	NN
cord-292688-w4zvfkyl	275	30	phospholipids	phospholipid	NNS
cord-292688-w4zvfkyl	275	31	Cantley	Cantley	NNP
cord-292688-w4zvfkyl	275	32	,	,	,
cord-292688-w4zvfkyl	275	33	Novel	novel	JJ
cord-292688-w4zvfkyl	275	34	function	function	NN
cord-292688-w4zvfkyl	275	35	of	of	IN
cord-292688-w4zvfkyl	275	36	phosphatidylinositol	phosphatidylinositol	JJ
cord-292688-w4zvfkyl	275	37	4,5-bisphosphate	4,5-bisphosphate	CD
cord-292688-w4zvfkyl	275	38	as	as	IN
cord-292688-w4zvfkyl	275	39	a	a	DT
cord-292688-w4zvfkyl	275	40	cofactor	cofactor	NN
cord-292688-w4zvfkyl	275	41	for	for	IN
cord-292688-w4zvfkyl	275	42	brain	brain	NN
cord-292688-w4zvfkyl	275	43	membrane	membrane	NN
cord-292688-w4zvfkyl	275	44	phospholipase	phospholipase	NN
cord-292688-w4zvfkyl	275	45	D	D	NNP
cord-292688-w4zvfkyl	275	46	A	A	NNP
cord-292688-w4zvfkyl	275	47	role	role	NN
cord-292688-w4zvfkyl	275	48	for	for	IN
cord-292688-w4zvfkyl	275	49	phosphatidylinositol	phosphatidylinositol	JJ
cord-292688-w4zvfkyl	275	50	transfer	transfer	NN
cord-292688-w4zvfkyl	275	51	protein	protein	NN
cord-292688-w4zvfkyl	275	52	in	in	IN
cord-292688-w4zvfkyl	275	53	secretory	secretory	JJ
cord-292688-w4zvfkyl	275	54	vesicle	vesicle	NN
cord-292688-w4zvfkyl	275	55	formation	formation	NN
cord-292688-w4zvfkyl	276	1	An	an	DT
cord-292688-w4zvfkyl	276	2	essential	essential	JJ
cord-292688-w4zvfkyl	276	3	role	role	NN
cord-292688-w4zvfkyl	276	4	for	for	IN
cord-292688-w4zvfkyl	276	5	a	a	DT
cord-292688-w4zvfkyl	276	6	phospholipid	phospholipid	NN
cord-292688-w4zvfkyl	276	7	transfer	transfer	NN
cord-292688-w4zvfkyl	276	8	protein	protein	NN
cord-292688-w4zvfkyl	276	9	in	in	IN
cord-292688-w4zvfkyl	276	10	yeast	yeast	NN
cord-292688-w4zvfkyl	276	11	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	276	12	function	function	NN
cord-292688-w4zvfkyl	276	13	Essential	essential	JJ
cord-292688-w4zvfkyl	276	14	role	role	NN
cord-292688-w4zvfkyl	276	15	for	for	IN
cord-292688-w4zvfkyl	276	16	diacylglycerol	diacylglycerol	NN
cord-292688-w4zvfkyl	276	17	in	in	IN
cord-292688-w4zvfkyl	276	18	protein	protein	NN
cord-292688-w4zvfkyl	276	19	transport	transport	NN
cord-292688-w4zvfkyl	276	20	from	from	IN
cord-292688-w4zvfkyl	276	21	the	the	DT
cord-292688-w4zvfkyl	276	22	yeast	yeast	NN
cord-292688-w4zvfkyl	276	23	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	276	24	complex	complex	JJ
cord-292688-w4zvfkyl	277	1	Greasing	grease	VBG
cord-292688-w4zvfkyl	277	2	the	the	DT
cord-292688-w4zvfkyl	277	3	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	277	4	budding	bud	VBG
cord-292688-w4zvfkyl	277	5	machine	machine	NN
cord-292688-w4zvfkyl	277	6	Vps34p	Vps34p	NNP
cord-292688-w4zvfkyl	277	7	required	require	VBN
cord-292688-w4zvfkyl	277	8	for	for	IN
cord-292688-w4zvfkyl	277	9	yeast	yeast	NN
cord-292688-w4zvfkyl	277	10	vacuolar	vacuolar	NNP
cord-292688-w4zvfkyl	277	11	protein	protein	NN
cord-292688-w4zvfkyl	277	12	sorting	sorting	NN
cord-292688-w4zvfkyl	277	13	is	be	VBZ
cord-292688-w4zvfkyl	277	14	a	a	DT
cord-292688-w4zvfkyl	277	15	multiple	multiple	JJ
cord-292688-w4zvfkyl	277	16	speci¢city	speci¢city	NN
cord-292688-w4zvfkyl	277	17	kinase	kinase	NN
cord-292688-w4zvfkyl	277	18	that	that	WDT
cord-292688-w4zvfkyl	277	19	exhibits	exhibit	VBZ
cord-292688-w4zvfkyl	277	20	both	both	DT
cord-292688-w4zvfkyl	277	21	protein	protein	NN
cord-292688-w4zvfkyl	277	22	kinase	kinase	NN
cord-292688-w4zvfkyl	277	23	and	and	CC
cord-292688-w4zvfkyl	277	24	phosphatidylinositol	phosphatidylinositol	NN
cord-292688-w4zvfkyl	277	25	-	-	HYPH
cord-292688-w4zvfkyl	277	26	speci¢c	speci¢c	JJ
cord-292688-w4zvfkyl	277	27	PI	pi	NN
cord-292688-w4zvfkyl	277	28	3-kinase	3-kinase	CD
cord-292688-w4zvfkyl	277	29	activities	activity	NNS
cord-292688-w4zvfkyl	277	30	Receptor	receptor	NN
cord-292688-w4zvfkyl	277	31	-	-	HYPH
cord-292688-w4zvfkyl	277	32	mediated	mediate	VBN
cord-292688-w4zvfkyl	277	33	protein	protein	NN
cord-292688-w4zvfkyl	277	34	sorting	sort	VBG
cord-292688-w4zvfkyl	277	35	to	to	IN
cord-292688-w4zvfkyl	277	36	the	the	DT
cord-292688-w4zvfkyl	277	37	vacuole	vacuole	NN
cord-292688-w4zvfkyl	277	38	in	in	IN
cord-292688-w4zvfkyl	277	39	yeast	yeast	NN
cord-292688-w4zvfkyl	277	40	:	:	:
cord-292688-w4zvfkyl	277	41	roles	role	NNS
cord-292688-w4zvfkyl	277	42	for	for	IN
cord-292688-w4zvfkyl	277	43	a	a	DT
cord-292688-w4zvfkyl	277	44	protein	protein	NN
cord-292688-w4zvfkyl	277	45	kinase	kinase	NN
cord-292688-w4zvfkyl	277	46	,	,	,
cord-292688-w4zvfkyl	277	47	a	a	DT
cord-292688-w4zvfkyl	277	48	lipid	lipid	NN
cord-292688-w4zvfkyl	277	49	kinase	kinase	NN
cord-292688-w4zvfkyl	277	50	and	and	CC
cord-292688-w4zvfkyl	277	51	GTP	gtp	NN
cord-292688-w4zvfkyl	277	52	-	-	HYPH
cord-292688-w4zvfkyl	277	53	binding	bind	VBG
cord-292688-w4zvfkyl	277	54	proteins	protein	NNS
cord-292688-w4zvfkyl	278	1	Phosphoinositide	Phosphoinositide	NNP
cord-292688-w4zvfkyl	278	2	3-kinases	3-kinases	CD
cord-292688-w4zvfkyl	278	3	and	and	CC
cord-292688-w4zvfkyl	278	4	membrane	membrane	NN
cord-292688-w4zvfkyl	278	5	tra¤c	tra¤c	NNP
cord-292688-w4zvfkyl	279	1	Phospatidylinositol	Phospatidylinositol	NNP
cord-292688-w4zvfkyl	279	2	3-kinase	3-kinase	NNP
cord-292688-w4zvfkyl	279	3	is	be	VBZ
cord-292688-w4zvfkyl	279	4	required	require	VBN
cord-292688-w4zvfkyl	279	5	for	for	IN
cord-292688-w4zvfkyl	279	6	the	the	DT
cord-292688-w4zvfkyl	279	7	formation	formation	NN
cord-292688-w4zvfkyl	279	8	of	of	IN
cord-292688-w4zvfkyl	279	9	constitutive	constitutive	JJ
cord-292688-w4zvfkyl	279	10	transport	transport	NN
cord-292688-w4zvfkyl	279	11	vesicles	vesicle	NNS
cord-292688-w4zvfkyl	279	12	from	from	IN
cord-292688-w4zvfkyl	279	13	the	the	DT
cord-292688-w4zvfkyl	279	14	TGN	TGN	NNP
cord-292688-w4zvfkyl	279	15	The	the	DT
cord-292688-w4zvfkyl	279	16	Lowe	Lowe	NNP
cord-292688-w4zvfkyl	279	17	's	's	POS
cord-292688-w4zvfkyl	279	18	oculocerebrorenal	oculocerebrorenal	JJ
cord-292688-w4zvfkyl	279	19	syndrome	syndrome	NNP
cord-292688-w4zvfkyl	279	20	gene	gene	NN
cord-292688-w4zvfkyl	279	21	encodes	encode	VBZ
cord-292688-w4zvfkyl	279	22	a	a	DT
cord-292688-w4zvfkyl	279	23	protein	protein	NN
cord-292688-w4zvfkyl	279	24	highly	highly	RB
cord-292688-w4zvfkyl	279	25	homologous	homologous	JJ
cord-292688-w4zvfkyl	279	26	to	to	IN
cord-292688-w4zvfkyl	279	27	inositol	inositol	NN
cord-292688-w4zvfkyl	279	28	polyphosphate-5-phosphatase	polyphosphate-5-phosphatase	NNP
cord-292688-w4zvfkyl	280	1	The	the	DT
cord-292688-w4zvfkyl	280	2	oculocerebrorenal	oculocerebrorenal	JJ
cord-292688-w4zvfkyl	280	3	syndrome	syndrome	NN
cord-292688-w4zvfkyl	280	4	gene	gene	NN
cord-292688-w4zvfkyl	280	5	product	product	NN
cord-292688-w4zvfkyl	280	6	is	be	VBZ
cord-292688-w4zvfkyl	280	7	a	a	DT
cord-292688-w4zvfkyl	280	8	105-kD	105-kd	CD
cord-292688-w4zvfkyl	280	9	protein	protein	NN
cord-292688-w4zvfkyl	280	10	localized	localize	VBN
cord-292688-w4zvfkyl	280	11	to	to	IN
cord-292688-w4zvfkyl	280	12	the	the	DT
cord-292688-w4zvfkyl	280	13	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	280	14	complex	complex	NN
cord-292688-w4zvfkyl	281	1	The	the	DT
cord-292688-w4zvfkyl	281	2	protein	protein	NN
cord-292688-w4zvfkyl	281	3	de¢cient	de¢cient	NN
cord-292688-w4zvfkyl	281	4	in	in	IN
cord-292688-w4zvfkyl	281	5	Lowe	Lowe	NNP
cord-292688-w4zvfkyl	281	6	syndrome	syndrome	NN
cord-292688-w4zvfkyl	281	7	is	be	VBZ
cord-292688-w4zvfkyl	281	8	a	a	DT
cord-292688-w4zvfkyl	281	9	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	NN
cord-292688-w4zvfkyl	281	10	5-phosphatase	5-phosphatase	CD
cord-292688-w4zvfkyl	281	11	A	a	DT
cord-292688-w4zvfkyl	281	12	role	role	NN
cord-292688-w4zvfkyl	281	13	of	of	IN
cord-292688-w4zvfkyl	281	14	amphiphysin	amphiphysin	NN
cord-292688-w4zvfkyl	281	15	in	in	IN
cord-292688-w4zvfkyl	281	16	synaptic	synaptic	JJ
cord-292688-w4zvfkyl	281	17	vesicle	vesicle	NN
cord-292688-w4zvfkyl	281	18	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	281	19	suggested	suggest	VBN
cord-292688-w4zvfkyl	281	20	by	by	IN
cord-292688-w4zvfkyl	281	21	its	-PRON-	PRP$
cord-292688-w4zvfkyl	281	22	binding	binding	NN
cord-292688-w4zvfkyl	281	23	to	to	IN
cord-292688-w4zvfkyl	281	24	dynamin	dynamin	NN
cord-292688-w4zvfkyl	281	25	in	in	IN
cord-292688-w4zvfkyl	281	26	nerve	nerve	NN
cord-292688-w4zvfkyl	281	27	terminals	terminal	NNS
cord-292688-w4zvfkyl	282	1	The	the	DT
cord-292688-w4zvfkyl	282	2	role	role	NN
cord-292688-w4zvfkyl	282	3	of	of	IN
cord-292688-w4zvfkyl	282	4	clathrin	clathrin	NN
cord-292688-w4zvfkyl	282	5	,	,	,
cord-292688-w4zvfkyl	282	6	adaptors	adaptor	NNS
cord-292688-w4zvfkyl	282	7	and	and	CC
cord-292688-w4zvfkyl	282	8	dynamin	dynamin	NN
cord-292688-w4zvfkyl	282	9	in	in	IN
cord-292688-w4zvfkyl	282	10	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	282	11	Dynamin	Dynamin	NNP
cord-292688-w4zvfkyl	282	12	and	and	CC
cord-292688-w4zvfkyl	282	13	receptor	receptor	NN
cord-292688-w4zvfkyl	282	14	-	-	HYPH
cord-292688-w4zvfkyl	282	15	mediated	mediate	VBN
cord-292688-w4zvfkyl	282	16	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	282	17	Molecular	Molecular	NNP
cord-292688-w4zvfkyl	282	18	mechanisms	mechanism	NNS
cord-292688-w4zvfkyl	282	19	in	in	IN
cord-292688-w4zvfkyl	282	20	synaptic	synaptic	JJ
cord-292688-w4zvfkyl	282	21	vesicle	vesicle	NN
cord-292688-w4zvfkyl	282	22	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	282	23	and	and	CC
cord-292688-w4zvfkyl	282	24	recycling	recycle	VBG
cord-292688-w4zvfkyl	282	25	Rapid	rapid	JJ
cord-292688-w4zvfkyl	282	26	endocytosis	endocytosis	NN
cord-292688-w4zvfkyl	282	27	coupled	couple	VBN
cord-292688-w4zvfkyl	282	28	to	to	IN
cord-292688-w4zvfkyl	282	29	exocytosis	exocytosis	NN
cord-292688-w4zvfkyl	282	30	in	in	IN
cord-292688-w4zvfkyl	282	31	adrenal	adrenal	JJ
cord-292688-w4zvfkyl	282	32	chro	chro	NN
cord-292688-w4zvfkyl	282	33	-	-	HYPH
cord-292688-w4zvfkyl	282	34	ma¤n	ma¤n	NN
cord-292688-w4zvfkyl	282	35	cells	cell	NNS
cord-292688-w4zvfkyl	282	36	involves	involve	VBZ
cord-292688-w4zvfkyl	282	37	Ca2	Ca2	NNP
cord-292688-w4zvfkyl	282	38	+	+	CC
cord-292688-w4zvfkyl	282	39	,	,	,
cord-292688-w4zvfkyl	282	40	GTP	GTP	NNP
cord-292688-w4zvfkyl	282	41	,	,	,
cord-292688-w4zvfkyl	282	42	and	and	CC
cord-292688-w4zvfkyl	282	43	dynamin	dynamin	NN
cord-292688-w4zvfkyl	282	44	but	but	CC
cord-292688-w4zvfkyl	282	45	not	not	RB
cord-292688-w4zvfkyl	282	46	clathrin	clathrin	VB
cord-292688-w4zvfkyl	282	47	Ringing	ring	VBG
cord-292688-w4zvfkyl	282	48	necks	neck	NNS
cord-292688-w4zvfkyl	282	49	with	with	IN
cord-292688-w4zvfkyl	282	50	dynamin	dynamin	NNP
cord-292688-w4zvfkyl	282	51	Association	Association	NNP
cord-292688-w4zvfkyl	282	52	of	of	IN
cord-292688-w4zvfkyl	282	53	a	a	DT
cord-292688-w4zvfkyl	282	54	dynamin	dynamin	NN
cord-292688-w4zvfkyl	282	55	-	-	HYPH
cord-292688-w4zvfkyl	282	56	like	like	JJ
cord-292688-w4zvfkyl	282	57	protein	protein	NN
cord-292688-w4zvfkyl	282	58	with	with	IN
cord-292688-w4zvfkyl	282	59	the	the	DT
cord-292688-w4zvfkyl	282	60	Golgi	Golgi	NNP
cord-292688-w4zvfkyl	282	61	apparatus	apparatus	NN
cord-292688-w4zvfkyl	282	62	in	in	IN
cord-292688-w4zvfkyl	282	63	mammalian	mammalian	JJ
cord-292688-w4zvfkyl	282	64	cells	cell	NNS
cord-292688-w4zvfkyl	283	1	The	the	DT
cord-292688-w4zvfkyl	283	2	AP-1	AP-1	NNP
cord-292688-w4zvfkyl	283	3	adaptor	adaptor	NN
cord-292688-w4zvfkyl	283	4	complex	complex	NN
cord-292688-w4zvfkyl	283	5	binds	bind	VBZ
cord-292688-w4zvfkyl	283	6	to	to	IN
cord-292688-w4zvfkyl	283	7	immature	immature	JJ
cord-292688-w4zvfkyl	283	8	secretory	secretory	JJ
cord-292688-w4zvfkyl	283	9	granules	granule	NNS
cord-292688-w4zvfkyl	283	10	from	from	IN
cord-292688-w4zvfkyl	283	11	PC12	pc12	JJ
cord-292688-w4zvfkyl	283	12	cells	cell	NNS
cord-292688-w4zvfkyl	283	13	,	,	,
cord-292688-w4zvfkyl	283	14	and	and	CC
cord-292688-w4zvfkyl	283	15	is	be	VBZ
cord-292688-w4zvfkyl	283	16	regulated	regulate	VBN
cord-292688-w4zvfkyl	283	17	by	by	IN
cord-292688-w4zvfkyl	283	18	ADP	adp	NN
cord-292688-w4zvfkyl	283	19	-	-	HYPH
cord-292688-w4zvfkyl	283	20	ribosylation	ribosylation	NN
cord-292688-w4zvfkyl	283	21	factor	factor	NN
cord-292688-w4zvfkyl	283	22	Essential	essential	JJ
cord-292688-w4zvfkyl	283	23	role	role	NN
cord-292688-w4zvfkyl	283	24	of	of	IN
cord-292688-w4zvfkyl	283	25	the	the	DT
cord-292688-w4zvfkyl	283	26	disul¢de	disul¢de	NN
cord-292688-w4zvfkyl	283	27	-	-	HYPH
cord-292688-w4zvfkyl	283	28	bonded	bond	VBN
cord-292688-w4zvfkyl	283	29	loop	loop	NN
cord-292688-w4zvfkyl	283	30	of	of	IN
cord-292688-w4zvfkyl	283	31	chromogranin	chromogranin	NNS
cord-292688-w4zvfkyl	283	32	B	B	NNP
cord-292688-w4zvfkyl	283	33	for	for	IN
cord-292688-w4zvfkyl	283	34	sorting	sort	VBG
cord-292688-w4zvfkyl	283	35	to	to	IN
cord-292688-w4zvfkyl	283	36	secretory	secretory	JJ
cord-292688-w4zvfkyl	283	37	granules	granule	NNS
cord-292688-w4zvfkyl	283	38	is	be	VBZ
cord-292688-w4zvfkyl	283	39	revealed	reveal	VBN
cord-292688-w4zvfkyl	283	40	by	by	IN
cord-292688-w4zvfkyl	283	41	expression	expression	NN
cord-292688-w4zvfkyl	283	42	of	of	IN
cord-292688-w4zvfkyl	283	43	a	a	DT
cord-292688-w4zvfkyl	283	44	deletion	deletion	NN
cord-292688-w4zvfkyl	283	45	mutant	mutant	JJ
cord-292688-w4zvfkyl	283	46	in	in	IN
cord-292688-w4zvfkyl	283	47	the	the	DT
cord-292688-w4zvfkyl	283	48	absence	absence	NN
cord-292688-w4zvfkyl	283	49	of	of	IN
cord-292688-w4zvfkyl	283	50	endogenous	endogenous	JJ
cord-292688-w4zvfkyl	283	51	granin	granin	NNP
cord-292688-w4zvfkyl	283	52	synthesis	synthesis	NN