id	sid	tid	token	lemma	pos
cord-291727-4wfhuvww	1	1	key	key	NN
cord-291727-4wfhuvww	1	2	:	:	:
cord-291727-4wfhuvww	2	1	cord-291727	cord-291727	NNP
cord-291727-4wfhuvww	2	2	-	-	HYPH
cord-291727-4wfhuvww	2	3	4wfhuvww	4wfhuvww	CD
cord-291727-4wfhuvww	2	4	authors	author	NNS
cord-291727-4wfhuvww	2	5	:	:	:
cord-291727-4wfhuvww	2	6	Ketteler	Ketteler	NNP
cord-291727-4wfhuvww	2	7	,	,	,
cord-291727-4wfhuvww	2	8	Robin	Robin	NNP
cord-291727-4wfhuvww	2	9	title	title	NN
cord-291727-4wfhuvww	2	10	:	:	:
cord-291727-4wfhuvww	2	11	On	on	IN
cord-291727-4wfhuvww	2	12	programmed	programmed	JJ
cord-291727-4wfhuvww	2	13	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	2	14	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	2	15	:	:	:
cord-291727-4wfhuvww	2	16	the	the	DT
cord-291727-4wfhuvww	2	17	alternative	alternative	JJ
cord-291727-4wfhuvww	2	18	proteomes	proteome	NNS
cord-291727-4wfhuvww	2	19	date	date	NN
cord-291727-4wfhuvww	2	20	:	:	:
cord-291727-4wfhuvww	2	21	2012	2012	CD
cord-291727-4wfhuvww	2	22	-	-	SYM
cord-291727-4wfhuvww	2	23	11	11	CD
cord-291727-4wfhuvww	2	24	-	-	SYM
cord-291727-4wfhuvww	2	25	19	19	CD
cord-291727-4wfhuvww	2	26	journal	journal	NN
cord-291727-4wfhuvww	2	27	:	:	:
cord-291727-4wfhuvww	2	28	Front	Front	NNP
cord-291727-4wfhuvww	2	29	Genet	Genet	NNP
cord-291727-4wfhuvww	2	30	DOI	DOI	NNP
cord-291727-4wfhuvww	2	31	:	:	:
cord-291727-4wfhuvww	2	32	10.3389	10.3389	CD
cord-291727-4wfhuvww	2	33	/	/	SYM
cord-291727-4wfhuvww	2	34	fgene.2012.00242	fgene.2012.00242	NN
cord-291727-4wfhuvww	2	35	sha	sha	NNP
cord-291727-4wfhuvww	2	36	:	:	:
cord-291727-4wfhuvww	2	37	4ec1787f65505b0751777ff1f2cb40d13c0d2b96	4ec1787f65505b0751777ff1f2cb40d13c0d2b96	CD
cord-291727-4wfhuvww	2	38	doc_id	doc_id	CD
cord-291727-4wfhuvww	2	39	:	:	:
cord-291727-4wfhuvww	2	40	291727	291727	CD
cord-291727-4wfhuvww	2	41	cord_uid	cord_uid	NNS
cord-291727-4wfhuvww	2	42	:	:	:
cord-291727-4wfhuvww	3	1	4wfhuvww	4wfhuvww	LS
cord-291727-4wfhuvww	3	2	Frameshifting	Frameshifting	NNP
cord-291727-4wfhuvww	3	3	results	result	NNS
cord-291727-4wfhuvww	3	4	from	from	IN
cord-291727-4wfhuvww	3	5	two	two	CD
cord-291727-4wfhuvww	3	6	main	main	JJ
cord-291727-4wfhuvww	3	7	mechanisms	mechanism	NNS
cord-291727-4wfhuvww	3	8	:	:	:
cord-291727-4wfhuvww	3	9	genomic	genomic	JJ
cord-291727-4wfhuvww	3	10	insertions	insertion	NNS
cord-291727-4wfhuvww	3	11	or	or	CC
cord-291727-4wfhuvww	3	12	deletions	deletion	NNS
cord-291727-4wfhuvww	3	13	(	(	-LRB-
cord-291727-4wfhuvww	3	14	indels	indel	NNS
cord-291727-4wfhuvww	3	15	)	)	-RRB-
cord-291727-4wfhuvww	3	16	or	or	CC
cord-291727-4wfhuvww	3	17	programmed	program	VBD
cord-291727-4wfhuvww	3	18	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	3	19	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	3	20	.	.	.
cord-291727-4wfhuvww	4	1	Whereas	whereas	IN
cord-291727-4wfhuvww	4	2	indels	indel	NNS
cord-291727-4wfhuvww	4	3	can	can	MD
cord-291727-4wfhuvww	4	4	disrupt	disrupt	VB
cord-291727-4wfhuvww	4	5	normal	normal	JJ
cord-291727-4wfhuvww	4	6	protein	protein	NN
cord-291727-4wfhuvww	4	7	function	function	NN
cord-291727-4wfhuvww	4	8	,	,	,
cord-291727-4wfhuvww	4	9	programmed	program	VBD
cord-291727-4wfhuvww	4	10	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	4	11	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	4	12	can	can	MD
cord-291727-4wfhuvww	4	13	result	result	VB
cord-291727-4wfhuvww	4	14	in	in	IN
cord-291727-4wfhuvww	4	15	dual	dual	JJ
cord-291727-4wfhuvww	4	16	-	-	HYPH
cord-291727-4wfhuvww	4	17	coding	code	VBG
cord-291727-4wfhuvww	4	18	genes	gene	NNS
cord-291727-4wfhuvww	4	19	,	,	,
cord-291727-4wfhuvww	4	20	each	each	DT
cord-291727-4wfhuvww	4	21	of	of	IN
cord-291727-4wfhuvww	4	22	which	which	WDT
cord-291727-4wfhuvww	4	23	can	can	MD
cord-291727-4wfhuvww	4	24	produce	produce	VB
cord-291727-4wfhuvww	4	25	multiple	multiple	JJ
cord-291727-4wfhuvww	4	26	functional	functional	JJ
cord-291727-4wfhuvww	4	27	products	product	NNS
cord-291727-4wfhuvww	4	28	.	.	.
cord-291727-4wfhuvww	5	1	Here	here	RB
cord-291727-4wfhuvww	5	2	,	,	,
cord-291727-4wfhuvww	5	3	I	-PRON-	PRP
cord-291727-4wfhuvww	5	4	summarize	summarize	VBP
cord-291727-4wfhuvww	5	5	technical	technical	JJ
cord-291727-4wfhuvww	5	6	advances	advance	NNS
cord-291727-4wfhuvww	5	7	that	that	WDT
cord-291727-4wfhuvww	5	8	have	have	VBP
cord-291727-4wfhuvww	5	9	made	make	VBN
cord-291727-4wfhuvww	5	10	it	-PRON-	PRP
cord-291727-4wfhuvww	5	11	possible	possible	JJ
cord-291727-4wfhuvww	5	12	to	to	TO
cord-291727-4wfhuvww	5	13	identify	identify	VB
cord-291727-4wfhuvww	5	14	programmed	program	VBN
cord-291727-4wfhuvww	5	15	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	5	16	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	5	17	events	event	NNS
cord-291727-4wfhuvww	5	18	in	in	IN
cord-291727-4wfhuvww	5	19	a	a	DT
cord-291727-4wfhuvww	5	20	systematic	systematic	JJ
cord-291727-4wfhuvww	5	21	way	way	NN
cord-291727-4wfhuvww	5	22	.	.	.
cord-291727-4wfhuvww	6	1	The	the	DT
cord-291727-4wfhuvww	6	2	results	result	NNS
cord-291727-4wfhuvww	6	3	of	of	IN
cord-291727-4wfhuvww	6	4	these	these	DT
cord-291727-4wfhuvww	6	5	studies	study	NNS
cord-291727-4wfhuvww	6	6	suggest	suggest	VBP
cord-291727-4wfhuvww	6	7	that	that	IN
cord-291727-4wfhuvww	6	8	such	such	JJ
cord-291727-4wfhuvww	6	9	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	6	10	occurs	occur	VBZ
cord-291727-4wfhuvww	6	11	in	in	IN
cord-291727-4wfhuvww	6	12	all	all	DT
cord-291727-4wfhuvww	6	13	genomes	genome	NNS
cord-291727-4wfhuvww	6	14	,	,	,
cord-291727-4wfhuvww	6	15	and	and	CC
cord-291727-4wfhuvww	6	16	I	-PRON-	PRP
cord-291727-4wfhuvww	6	17	will	will	MD
cord-291727-4wfhuvww	6	18	discuss	discuss	VB
cord-291727-4wfhuvww	6	19	methods	method	NNS
cord-291727-4wfhuvww	6	20	that	that	WDT
cord-291727-4wfhuvww	6	21	could	could	MD
cord-291727-4wfhuvww	6	22	help	help	VB
cord-291727-4wfhuvww	6	23	characterize	characterize	VB
cord-291727-4wfhuvww	6	24	the	the	DT
cord-291727-4wfhuvww	6	25	resulting	result	VBG
cord-291727-4wfhuvww	6	26	alternative	alternative	JJ
cord-291727-4wfhuvww	6	27	proteomes	proteome	NNS
cord-291727-4wfhuvww	6	28	.	.	.
cord-291727-4wfhuvww	7	1	Frameshifting	Frameshifting	NNP
cord-291727-4wfhuvww	7	2	is	be	VBZ
cord-291727-4wfhuvww	7	3	a	a	DT
cord-291727-4wfhuvww	7	4	process	process	NN
cord-291727-4wfhuvww	7	5	whereby	whereby	WRB
cord-291727-4wfhuvww	7	6	the	the	DT
cord-291727-4wfhuvww	7	7	ribosome	ribosome	NN
cord-291727-4wfhuvww	7	8	is	be	VBZ
cord-291727-4wfhuvww	7	9	guided	guide	VBN
cord-291727-4wfhuvww	7	10	toward	toward	IN
cord-291727-4wfhuvww	7	11	a	a	DT
cord-291727-4wfhuvww	7	12	triplet	triplet	NN
cord-291727-4wfhuvww	7	13	nucleotide	nucleotide	NN
cord-291727-4wfhuvww	7	14	that	that	WDT
cord-291727-4wfhuvww	7	15	is	be	VBZ
cord-291727-4wfhuvww	7	16	either	either	CC
cord-291727-4wfhuvww	7	17	shifted	shift	VBN
cord-291727-4wfhuvww	7	18	one	one	CD
cord-291727-4wfhuvww	7	19	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	7	20	position	position	NN
cord-291727-4wfhuvww	7	21	upstream	upstream	RB
cord-291727-4wfhuvww	7	22	(	(	-LRB-
cord-291727-4wfhuvww	7	23	+1	+1	XX
cord-291727-4wfhuvww	7	24	frameshift	frameshift	NN
cord-291727-4wfhuvww	7	25	)	)	-RRB-
cord-291727-4wfhuvww	7	26	or	or	CC
cord-291727-4wfhuvww	7	27	one	one	CD
cord-291727-4wfhuvww	7	28	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	7	29	position	position	NN
cord-291727-4wfhuvww	7	30	downstream	downstream	JJ
cord-291727-4wfhuvww	7	31	(	(	-LRB-
cord-291727-4wfhuvww	7	32	−1	−1	NNP
cord-291727-4wfhuvww	7	33	frameshift	frameshift	NN
cord-291727-4wfhuvww	7	34	)	)	-RRB-
cord-291727-4wfhuvww	7	35	.	.	.
cord-291727-4wfhuvww	8	1	Such	such	JJ
cord-291727-4wfhuvww	8	2	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	8	3	occurs	occur	VBZ
cord-291727-4wfhuvww	8	4	in	in	IN
cord-291727-4wfhuvww	8	5	all	all	DT
cord-291727-4wfhuvww	8	6	known	know	VBN
cord-291727-4wfhuvww	8	7	organisms	organism	NNS
cord-291727-4wfhuvww	8	8	,	,	,
cord-291727-4wfhuvww	8	9	from	from	IN
cord-291727-4wfhuvww	8	10	E.	E.	NNP
cord-291727-4wfhuvww	8	11	coli	coli	NNS
cord-291727-4wfhuvww	8	12	to	to	IN
cord-291727-4wfhuvww	8	13	mammals	mammal	NNS
cord-291727-4wfhuvww	9	1	(	(	-LRB-
cord-291727-4wfhuvww	9	2	Namy	Namy	NNP
cord-291727-4wfhuvww	9	3	et	et	NNP
cord-291727-4wfhuvww	9	4	al	al	NNP
cord-291727-4wfhuvww	9	5	.	.	NNP
cord-291727-4wfhuvww	9	6	,	,	,
cord-291727-4wfhuvww	9	7	2004	2004	CD
cord-291727-4wfhuvww	10	1	;	;	:
cord-291727-4wfhuvww	10	2	Dinman	Dinman	NNP
cord-291727-4wfhuvww	10	3	,	,	,
cord-291727-4wfhuvww	10	4	2012a	2012a	CD
cord-291727-4wfhuvww	10	5	)	)	-RRB-
cord-291727-4wfhuvww	10	6	.	.	.
cord-291727-4wfhuvww	11	1	There	there	EX
cord-291727-4wfhuvww	11	2	are	be	VBP
cord-291727-4wfhuvww	11	3	two	two	CD
cord-291727-4wfhuvww	11	4	main	main	JJ
cord-291727-4wfhuvww	11	5	mechanisms	mechanism	NNS
cord-291727-4wfhuvww	11	6	that	that	WDT
cord-291727-4wfhuvww	11	7	produce	produce	VBP
cord-291727-4wfhuvww	11	8	out	out	IN
cord-291727-4wfhuvww	11	9	of	of	IN
cord-291727-4wfhuvww	11	10	frame	frame	NN
cord-291727-4wfhuvww	11	11	peptides	peptide	NNS
cord-291727-4wfhuvww	11	12	:	:	:
cord-291727-4wfhuvww	11	13	changes	change	NNS
cord-291727-4wfhuvww	11	14	in	in	IN
cord-291727-4wfhuvww	11	15	the	the	DT
cord-291727-4wfhuvww	11	16	genome	genome	NN
cord-291727-4wfhuvww	11	17	sequence	sequence	NN
cord-291727-4wfhuvww	11	18	that	that	WDT
cord-291727-4wfhuvww	11	19	result	result	VBP
cord-291727-4wfhuvww	11	20	in	in	IN
cord-291727-4wfhuvww	11	21	insertions	insertion	NNS
cord-291727-4wfhuvww	11	22	or	or	CC
cord-291727-4wfhuvww	11	23	deletions	deletion	NNS
cord-291727-4wfhuvww	11	24	(	(	-LRB-
cord-291727-4wfhuvww	11	25	indels	indel	NNS
cord-291727-4wfhuvww	11	26	)	)	-RRB-
cord-291727-4wfhuvww	11	27	and	and	CC
cord-291727-4wfhuvww	11	28	programmed	program	VBD
cord-291727-4wfhuvww	11	29	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	11	30	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	11	31	as	as	IN
cord-291727-4wfhuvww	11	32	a	a	DT
cord-291727-4wfhuvww	11	33	consequence	consequence	NN
cord-291727-4wfhuvww	11	34	of	of	IN
cord-291727-4wfhuvww	11	35	the	the	DT
cord-291727-4wfhuvww	11	36	ribosome	ribosome	NN
cord-291727-4wfhuvww	11	37	either	either	CC
cord-291727-4wfhuvww	11	38	slipping	slip	VBG
cord-291727-4wfhuvww	11	39	back	back	RB
cord-291727-4wfhuvww	11	40	one	one	CD
cord-291727-4wfhuvww	11	41	nucleotide	nucleotide	NN
cord-291727-4wfhuvww	11	42	(	(	-LRB-
cord-291727-4wfhuvww	11	43	−1	−1	NNP
cord-291727-4wfhuvww	11	44	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	11	45	)	)	-RRB-
cord-291727-4wfhuvww	11	46	or	or	CC
cord-291727-4wfhuvww	11	47	skipping	skip	VBG
cord-291727-4wfhuvww	11	48	one	one	CD
cord-291727-4wfhuvww	11	49	nucleotide	nucleotide	NN
cord-291727-4wfhuvww	11	50	(	(	-LRB-
cord-291727-4wfhuvww	11	51	+1	+1	NNP
cord-291727-4wfhuvww	11	52	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	11	53	)	)	-RRB-
cord-291727-4wfhuvww	12	1	(	(	-LRB-
cord-291727-4wfhuvww	12	2	Figure	figure	NN
cord-291727-4wfhuvww	12	3	1	1	CD
cord-291727-4wfhuvww	12	4	)	)	-RRB-
cord-291727-4wfhuvww	12	5	.	.	.
cord-291727-4wfhuvww	13	1	Indels	Indels	NNP
cord-291727-4wfhuvww	13	2	generally	generally	RB
cord-291727-4wfhuvww	13	3	produce	produce	VBP
cord-291727-4wfhuvww	13	4	nonfunctional	nonfunctional	JJ
cord-291727-4wfhuvww	13	5	proteins	protein	NNS
cord-291727-4wfhuvww	13	6	and	and	CC
cord-291727-4wfhuvww	13	7	are	be	VBP
cord-291727-4wfhuvww	13	8	associated	associate	VBN
cord-291727-4wfhuvww	13	9	with	with	IN
cord-291727-4wfhuvww	13	10	either	either	DT
cord-291727-4wfhuvww	13	11	spontaneous	spontaneous	JJ
cord-291727-4wfhuvww	13	12	mutations	mutation	NNS
cord-291727-4wfhuvww	13	13	across	across	IN
cord-291727-4wfhuvww	13	14	the	the	DT
cord-291727-4wfhuvww	13	15	genome	genome	NN
cord-291727-4wfhuvww	13	16	or	or	CC
cord-291727-4wfhuvww	13	17	somatic	somatic	JJ
cord-291727-4wfhuvww	13	18	genomic	genomic	JJ
cord-291727-4wfhuvww	13	19	instability	instability	NN
cord-291727-4wfhuvww	13	20	,	,	,
cord-291727-4wfhuvww	13	21	for	for	IN
cord-291727-4wfhuvww	13	22	instance	instance	NN
cord-291727-4wfhuvww	13	23	,	,	,
cord-291727-4wfhuvww	13	24	as	as	IN
cord-291727-4wfhuvww	13	25	a	a	DT
cord-291727-4wfhuvww	13	26	consequence	consequence	NN
cord-291727-4wfhuvww	13	27	of	of	IN
cord-291727-4wfhuvww	13	28	tumour	tumour	NN
cord-291727-4wfhuvww	13	29	progression	progression	NN
cord-291727-4wfhuvww	13	30	.	.	.
cord-291727-4wfhuvww	14	1	By	by	IN
cord-291727-4wfhuvww	14	2	contrast	contrast	NN
cord-291727-4wfhuvww	14	3	,	,	,
cord-291727-4wfhuvww	14	4	programmed	program	VBD
cord-291727-4wfhuvww	14	5	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	14	6	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	14	7	can	can	MD
cord-291727-4wfhuvww	14	8	result	result	VB
cord-291727-4wfhuvww	14	9	in	in	IN
cord-291727-4wfhuvww	14	10	dual	dual	JJ
cord-291727-4wfhuvww	14	11	-	-	HYPH
cord-291727-4wfhuvww	14	12	coding	code	VBG
cord-291727-4wfhuvww	14	13	genes	gene	NNS
cord-291727-4wfhuvww	14	14	that	that	WDT
cord-291727-4wfhuvww	14	15	produce	produce	VBP
cord-291727-4wfhuvww	14	16	alternative	alternative	JJ
cord-291727-4wfhuvww	14	17	functional	functional	JJ
cord-291727-4wfhuvww	14	18	proteins	protein	NNS
cord-291727-4wfhuvww	14	19	,	,	,
cord-291727-4wfhuvww	14	20	which	which	WDT
cord-291727-4wfhuvww	14	21	form	form	VBP
cord-291727-4wfhuvww	14	22	an	an	DT
cord-291727-4wfhuvww	14	23	integral	integral	JJ
cord-291727-4wfhuvww	14	24	part	part	NN
cord-291727-4wfhuvww	14	25	of	of	IN
cord-291727-4wfhuvww	14	26	the	the	DT
cord-291727-4wfhuvww	14	27	organism	organism	NN
cord-291727-4wfhuvww	14	28	's	's	POS
cord-291727-4wfhuvww	14	29	physiology	physiology	NN
cord-291727-4wfhuvww	14	30	.	.	.
cord-291727-4wfhuvww	15	1	Programmed	program	VBN
cord-291727-4wfhuvww	15	2	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	15	3	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	15	4	has	have	VBZ
cord-291727-4wfhuvww	15	5	been	be	VBN
cord-291727-4wfhuvww	15	6	historically	historically	RB
cord-291727-4wfhuvww	15	7	associated	associate	VBN
cord-291727-4wfhuvww	15	8	with	with	IN
cord-291727-4wfhuvww	15	9	viruses	virus	NNS
cord-291727-4wfhuvww	15	10	and	and	CC
cord-291727-4wfhuvww	15	11	retrotransposons	retrotransposon	NNS
cord-291727-4wfhuvww	15	12	.	.	.
cord-291727-4wfhuvww	16	1	Retroviruses	retrovirus	NNS
cord-291727-4wfhuvww	16	2	require	require	VBP
cord-291727-4wfhuvww	16	3	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	16	4	for	for	IN
cord-291727-4wfhuvww	16	5	replication	replication	NN
cord-291727-4wfhuvww	16	6	and	and	CC
cord-291727-4wfhuvww	16	7	infection	infection	NN
cord-291727-4wfhuvww	17	1	(	(	-LRB-
cord-291727-4wfhuvww	17	2	Maia	Maia	NNP
cord-291727-4wfhuvww	17	3	et	et	NNP
cord-291727-4wfhuvww	17	4	al	al	NNP
cord-291727-4wfhuvww	17	5	.	.	NNP
cord-291727-4wfhuvww	17	6	,	,	,
cord-291727-4wfhuvww	17	7	1996	1996	CD
cord-291727-4wfhuvww	17	8	;	;	:
cord-291727-4wfhuvww	17	9	Brierley	Brierley	NNP
cord-291727-4wfhuvww	17	10	and	and	CC
cord-291727-4wfhuvww	17	11	Dos	Dos	NNP
cord-291727-4wfhuvww	17	12	Ramos	Ramos	NNP
cord-291727-4wfhuvww	17	13	,	,	,
cord-291727-4wfhuvww	17	14	2006	2006	CD
cord-291727-4wfhuvww	17	15	;	;	:
cord-291727-4wfhuvww	17	16	Dulude	Dulude	NNP
cord-291727-4wfhuvww	17	17	et	et	NNP
cord-291727-4wfhuvww	17	18	al	al	NNP
cord-291727-4wfhuvww	17	19	.	.	NNP
cord-291727-4wfhuvww	17	20	,	,	,
cord-291727-4wfhuvww	17	21	2006	2006	CD
cord-291727-4wfhuvww	17	22	)	)	-RRB-
cord-291727-4wfhuvww	17	23	.	.	.
cord-291727-4wfhuvww	18	1	For	for	IN
cord-291727-4wfhuvww	18	2	example	example	NN
cord-291727-4wfhuvww	18	3	,	,	,
cord-291727-4wfhuvww	18	4	the	the	DT
cord-291727-4wfhuvww	18	5	HIV1	HIV1	NNP
cord-291727-4wfhuvww	18	6	polyprotein	polyprotein	NN
cord-291727-4wfhuvww	18	7	gag	gag	NN
cord-291727-4wfhuvww	18	8	-	-	HYPH
cord-291727-4wfhuvww	18	9	pol	pol	NN
cord-291727-4wfhuvww	18	10	requires	require	VBZ
cord-291727-4wfhuvww	18	11	efficient	efficient	JJ
cord-291727-4wfhuvww	18	12	−1	−1	NNP
cord-291727-4wfhuvww	18	13	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	18	14	for	for	IN
cord-291727-4wfhuvww	18	15	expression	expression	NN
cord-291727-4wfhuvww	18	16	of	of	IN
cord-291727-4wfhuvww	18	17	the	the	DT
cord-291727-4wfhuvww	18	18	individual	individual	JJ
cord-291727-4wfhuvww	18	19	gag	gag	NN
cord-291727-4wfhuvww	18	20	and	and	CC
cord-291727-4wfhuvww	18	21	pol	pol	NN
cord-291727-4wfhuvww	18	22	gene	gene	NN
cord-291727-4wfhuvww	18	23	products	product	NNS
cord-291727-4wfhuvww	18	24	.	.	.
cord-291727-4wfhuvww	19	1	This	this	DT
cord-291727-4wfhuvww	19	2	form	form	NN
cord-291727-4wfhuvww	19	3	of	of	IN
cord-291727-4wfhuvww	19	4	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	19	5	usually	usually	RB
cord-291727-4wfhuvww	19	6	depends	depend	VBZ
cord-291727-4wfhuvww	19	7	on	on	IN
cord-291727-4wfhuvww	19	8	a	a	DT
cord-291727-4wfhuvww	19	9	combination	combination	NN
cord-291727-4wfhuvww	19	10	of	of	IN
cord-291727-4wfhuvww	19	11	a	a	DT
cord-291727-4wfhuvww	19	12	"	"	``
cord-291727-4wfhuvww	19	13	slippery	slippery	JJ
cord-291727-4wfhuvww	19	14	sequence	sequence	NN
cord-291727-4wfhuvww	19	15	,	,	,
cord-291727-4wfhuvww	19	16	"	"	''
cord-291727-4wfhuvww	19	17	a	a	DT
cord-291727-4wfhuvww	19	18	spacer	spacer	NN
cord-291727-4wfhuvww	19	19	sequence	sequence	NN
cord-291727-4wfhuvww	19	20	of	of	IN
cord-291727-4wfhuvww	19	21	1	1	CD
cord-291727-4wfhuvww	19	22	-	-	SYM
cord-291727-4wfhuvww	19	23	15	15	CD
cord-291727-4wfhuvww	19	24	nucleotides	nucleotide	NNS
cord-291727-4wfhuvww	19	25	,	,	,
cord-291727-4wfhuvww	19	26	and	and	CC
cord-291727-4wfhuvww	19	27	a	a	DT
cord-291727-4wfhuvww	19	28	stem	stem	NN
cord-291727-4wfhuvww	19	29	-	-	HYPH
cord-291727-4wfhuvww	19	30	loop	loop	NN
cord-291727-4wfhuvww	19	31	secondary	secondary	JJ
cord-291727-4wfhuvww	19	32	RNA	RNA	NNP
cord-291727-4wfhuvww	19	33	structure	structure	NN
cord-291727-4wfhuvww	19	34	such	such	JJ
cord-291727-4wfhuvww	19	35	as	as	IN
cord-291727-4wfhuvww	19	36	a	a	DT
cord-291727-4wfhuvww	19	37	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	19	38	(	(	-LRB-
cord-291727-4wfhuvww	19	39	Figure	figure	NN
cord-291727-4wfhuvww	19	40	1	1	CD
cord-291727-4wfhuvww	19	41	)	)	-RRB-
cord-291727-4wfhuvww	20	1	(	(	-LRB-
cord-291727-4wfhuvww	20	2	Namy	Namy	NNP
cord-291727-4wfhuvww	20	3	et	et	NNP
cord-291727-4wfhuvww	20	4	al	al	NNP
cord-291727-4wfhuvww	20	5	.	.	NNP
cord-291727-4wfhuvww	20	6	,	,	,
cord-291727-4wfhuvww	20	7	2006	2006	CD
cord-291727-4wfhuvww	20	8	)	)	-RRB-
cord-291727-4wfhuvww	20	9	.	.	.
cord-291727-4wfhuvww	21	1	The	the	DT
cord-291727-4wfhuvww	21	2	slippery	slippery	JJ
cord-291727-4wfhuvww	21	3	sequence	sequence	NN
cord-291727-4wfhuvww	21	4	is	be	VBZ
cord-291727-4wfhuvww	21	5	generally	generally	RB
cord-291727-4wfhuvww	21	6	of	of	IN
cord-291727-4wfhuvww	21	7	the	the	DT
cord-291727-4wfhuvww	21	8	type	type	NN
cord-291727-4wfhuvww	21	9	X	x	NN
cord-291727-4wfhuvww	21	10	XXY	XXY	NNP
cord-291727-4wfhuvww	21	11	YYZ	YYZ	NNP
cord-291727-4wfhuvww	21	12	,	,	,
cord-291727-4wfhuvww	21	13	where	where	WRB
cord-291727-4wfhuvww	21	14	X	x	NN
cord-291727-4wfhuvww	21	15	denotes	denote	VBZ
cord-291727-4wfhuvww	21	16	any	any	DT
cord-291727-4wfhuvww	21	17	nucleotide	nucleotide	NN
cord-291727-4wfhuvww	21	18	,	,	,
cord-291727-4wfhuvww	21	19	Y	Y	NNP
cord-291727-4wfhuvww	21	20	denotes	denote	VBZ
cord-291727-4wfhuvww	21	21	A	a	NN
cord-291727-4wfhuvww	21	22	or	or	CC
cord-291727-4wfhuvww	21	23	U	u	NN
cord-291727-4wfhuvww	21	24	,	,	,
cord-291727-4wfhuvww	21	25	and	and	CC
cord-291727-4wfhuvww	21	26	Z	z	NN
cord-291727-4wfhuvww	21	27	is	be	VBZ
cord-291727-4wfhuvww	21	28	A	a	NN
cord-291727-4wfhuvww	21	29	,	,	,
cord-291727-4wfhuvww	21	30	U	U	NNP
cord-291727-4wfhuvww	21	31	,	,	,
cord-291727-4wfhuvww	21	32	or	or	CC
cord-291727-4wfhuvww	21	33	C.	C.	NNP
cord-291727-4wfhuvww	21	34	Pseudoknots	Pseudoknots	NNP
cord-291727-4wfhuvww	21	35	are	be	VBP
cord-291727-4wfhuvww	21	36	secondary	secondary	JJ
cord-291727-4wfhuvww	21	37	RNA	RNA	NNP
cord-291727-4wfhuvww	21	38	substructures	substructure	NNS
cord-291727-4wfhuvww	21	39	that	that	WDT
cord-291727-4wfhuvww	21	40	contain	contain	VBP
cord-291727-4wfhuvww	21	41	two	two	CD
cord-291727-4wfhuvww	21	42	or	or	CC
cord-291727-4wfhuvww	21	43	more	more	JJR
cord-291727-4wfhuvww	21	44	stemloop	stemloop	JJ
cord-291727-4wfhuvww	21	45	motifs	motif	NNS
cord-291727-4wfhuvww	21	46	with	with	IN
cord-291727-4wfhuvww	21	47	intercalated	intercalate	VBN
cord-291727-4wfhuvww	21	48	stems	stem	NNS
cord-291727-4wfhuvww	21	49	.	.	.
cord-291727-4wfhuvww	22	1	The	the	DT
cord-291727-4wfhuvww	22	2	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	22	3	or	or	CC
cord-291727-4wfhuvww	22	4	stemloop	stemloop	JJ
cord-291727-4wfhuvww	22	5	structure	structure	NN
cord-291727-4wfhuvww	22	6	in	in	IN
cord-291727-4wfhuvww	22	7	the	the	DT
cord-291727-4wfhuvww	22	8	mRNA	mRNA	NNP
cord-291727-4wfhuvww	22	9	is	be	VBZ
cord-291727-4wfhuvww	22	10	thought	think	VBN
cord-291727-4wfhuvww	22	11	to	to	TO
cord-291727-4wfhuvww	22	12	result	result	VB
cord-291727-4wfhuvww	22	13	in	in	IN
cord-291727-4wfhuvww	22	14	pausing	pausing	NN
cord-291727-4wfhuvww	22	15	of	of	IN
cord-291727-4wfhuvww	22	16	the	the	DT
cord-291727-4wfhuvww	22	17	ribosome	ribosome	NN
cord-291727-4wfhuvww	22	18	,	,	,
cord-291727-4wfhuvww	22	19	resulting	result	VBG
cord-291727-4wfhuvww	22	20	in	in	IN
cord-291727-4wfhuvww	22	21	eventual	eventual	JJ
cord-291727-4wfhuvww	22	22	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	23	1	(	(	-LRB-
cord-291727-4wfhuvww	23	2	Namy	Namy	NNP
cord-291727-4wfhuvww	23	3	et	et	NNP
cord-291727-4wfhuvww	23	4	al	al	NNP
cord-291727-4wfhuvww	23	5	.	.	NNP
cord-291727-4wfhuvww	23	6	,	,	,
cord-291727-4wfhuvww	23	7	2006	2006	CD
cord-291727-4wfhuvww	23	8	)	)	-RRB-
cord-291727-4wfhuvww	23	9	.	.	.
cord-291727-4wfhuvww	24	1	Structural	structural	JJ
cord-291727-4wfhuvww	24	2	evidence	evidence	NN
cord-291727-4wfhuvww	24	3	for	for	IN
cord-291727-4wfhuvww	24	4	this	this	DT
cord-291727-4wfhuvww	24	5	mechanism	mechanism	NN
cord-291727-4wfhuvww	24	6	comes	come	VBZ
cord-291727-4wfhuvww	24	7	from	from	IN
cord-291727-4wfhuvww	24	8	the	the	DT
cord-291727-4wfhuvww	24	9	crystal	crystal	JJ
cord-291727-4wfhuvww	24	10	structure	structure	NN
cord-291727-4wfhuvww	24	11	of	of	IN
cord-291727-4wfhuvww	24	12	the	the	DT
cord-291727-4wfhuvww	24	13	mouse	mouse	NN
cord-291727-4wfhuvww	24	14	mammary	mammary	JJ
cord-291727-4wfhuvww	24	15	tumor	tumor	NN
cord-291727-4wfhuvww	24	16	virus	virus	NN
cord-291727-4wfhuvww	24	17	(	(	-LRB-
cord-291727-4wfhuvww	24	18	MMTV	MMTV	NNP
cord-291727-4wfhuvww	24	19	)	)	-RRB-
cord-291727-4wfhuvww	24	20	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	24	21	,	,	,
cord-291727-4wfhuvww	24	22	which	which	WDT
cord-291727-4wfhuvww	24	23	has	have	VBZ
cord-291727-4wfhuvww	24	24	an	an	DT
cord-291727-4wfhuvww	24	25	unpaired	unpaired	JJ
cord-291727-4wfhuvww	24	26	adenine	adenine	NN
cord-291727-4wfhuvww	24	27	that	that	WDT
cord-291727-4wfhuvww	24	28	acts	act	VBZ
cord-291727-4wfhuvww	24	29	as	as	IN
cord-291727-4wfhuvww	24	30	a	a	DT
cord-291727-4wfhuvww	24	31	hinge	hinge	NN
cord-291727-4wfhuvww	24	32	to	to	TO
cord-291727-4wfhuvww	24	33	mediate	mediate	VB
cord-291727-4wfhuvww	24	34	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	25	1	(	(	-LRB-
cord-291727-4wfhuvww	25	2	Chen	Chen	NNP
cord-291727-4wfhuvww	25	3	et	et	NNP
cord-291727-4wfhuvww	25	4	al	al	NNP
cord-291727-4wfhuvww	25	5	.	.	NNP
cord-291727-4wfhuvww	25	6	,	,	,
cord-291727-4wfhuvww	25	7	1996	1996	CD
cord-291727-4wfhuvww	25	8	)	)	-RRB-
cord-291727-4wfhuvww	25	9	.	.	.
cord-291727-4wfhuvww	26	1	Generally	generally	RB
cord-291727-4wfhuvww	26	2	,	,	,
cord-291727-4wfhuvww	26	3	there	there	EX
cord-291727-4wfhuvww	26	4	is	be	VBZ
cord-291727-4wfhuvww	26	5	a	a	DT
cord-291727-4wfhuvww	26	6	correlation	correlation	NN
cord-291727-4wfhuvww	26	7	between	between	IN
cord-291727-4wfhuvww	26	8	the	the	DT
cord-291727-4wfhuvww	26	9	mechanical	mechanical	JJ
cord-291727-4wfhuvww	26	10	strength	strength	NN
cord-291727-4wfhuvww	26	11	of	of	IN
cord-291727-4wfhuvww	26	12	an	an	DT
cord-291727-4wfhuvww	26	13	mRNA	mRNA	NNP
cord-291727-4wfhuvww	26	14	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	26	15	and	and	CC
cord-291727-4wfhuvww	26	16	its	-PRON-	PRP$
cord-291727-4wfhuvww	26	17	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	26	18	efficiency	efficiency	NN
cord-291727-4wfhuvww	27	1	(	(	-LRB-
cord-291727-4wfhuvww	27	2	Hansen	Hansen	NNP
cord-291727-4wfhuvww	27	3	et	et	NNP
cord-291727-4wfhuvww	27	4	al	al	NNP
cord-291727-4wfhuvww	27	5	.	.	NNP
cord-291727-4wfhuvww	27	6	,	,	,
cord-291727-4wfhuvww	27	7	2007	2007	CD
cord-291727-4wfhuvww	27	8	)	)	-RRB-
cord-291727-4wfhuvww	28	1	:	:	:
cord-291727-4wfhuvww	28	2	the	the	DT
cord-291727-4wfhuvww	28	3	stronger	strong	JJR
cord-291727-4wfhuvww	28	4	the	the	DT
cord-291727-4wfhuvww	28	5	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	28	6	the	the	DT
cord-291727-4wfhuvww	28	7	higher	high	JJR
cord-291727-4wfhuvww	29	1	the	the	DT
cord-291727-4wfhuvww	29	2	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	29	3	efficiency	efficiency	NN
cord-291727-4wfhuvww	29	4	,	,	,
cord-291727-4wfhuvww	29	5	although	although	IN
cord-291727-4wfhuvww	29	6	very	very	RB
cord-291727-4wfhuvww	29	7	strong	strong	JJ
cord-291727-4wfhuvww	29	8	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	29	9	can	can	MD
cord-291727-4wfhuvww	29	10	cause	cause	VB
cord-291727-4wfhuvww	29	11	a	a	DT
cord-291727-4wfhuvww	29	12	road	road	NN
cord-291727-4wfhuvww	29	13	block	block	NN
cord-291727-4wfhuvww	29	14	that	that	WDT
cord-291727-4wfhuvww	29	15	limits	limit	VBZ
cord-291727-4wfhuvww	29	16	translation	translation	NN
cord-291727-4wfhuvww	29	17	downstream	downstream	RB
cord-291727-4wfhuvww	30	1	(	(	-LRB-
cord-291727-4wfhuvww	30	2	Tholstrup	Tholstrup	NNP
cord-291727-4wfhuvww	30	3	et	et	NNP
cord-291727-4wfhuvww	30	4	al	al	NNP
cord-291727-4wfhuvww	30	5	.	.	NNP
cord-291727-4wfhuvww	30	6	,	,	,
cord-291727-4wfhuvww	30	7	2011	2011	CD
cord-291727-4wfhuvww	30	8	)	)	-RRB-
cord-291727-4wfhuvww	30	9	.	.	.
cord-291727-4wfhuvww	31	1	Other	other	JJ
cord-291727-4wfhuvww	31	2	examples	example	NNS
cord-291727-4wfhuvww	31	3	of	of	IN
cord-291727-4wfhuvww	31	4	mammalian	mammalian	JJ
cord-291727-4wfhuvww	31	5	genes	gene	NNS
cord-291727-4wfhuvww	31	6	that	that	WDT
cord-291727-4wfhuvww	31	7	utilize	utilize	VBP
cord-291727-4wfhuvww	31	8	−1	−1	NNP
cord-291727-4wfhuvww	31	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	31	10	are	be	VBP
cord-291727-4wfhuvww	31	11	the	the	DT
cord-291727-4wfhuvww	31	12	mouse	mouse	NN
cord-291727-4wfhuvww	31	13	embryonic	embryonic	JJ
cord-291727-4wfhuvww	31	14	carcinoma	carcinoma	NN
cord-291727-4wfhuvww	31	15	differentiation	differentiation	NN
cord-291727-4wfhuvww	31	16	regulated	regulate	VBN
cord-291727-4wfhuvww	31	17	(	(	-LRB-
cord-291727-4wfhuvww	31	18	EDR	EDR	NNP
cord-291727-4wfhuvww	31	19	)	)	-RRB-
cord-291727-4wfhuvww	31	20	gene	gene	NN
cord-291727-4wfhuvww	31	21	and	and	CC
cord-291727-4wfhuvww	31	22	its	-PRON-	PRP$
cord-291727-4wfhuvww	31	23	human	human	JJ
cord-291727-4wfhuvww	31	24	ortholog	ortholog	NN
cord-291727-4wfhuvww	31	25	PEG10	PEG10	NNP
cord-291727-4wfhuvww	31	26	.	.	.
cord-291727-4wfhuvww	32	1	A	a	DT
cord-291727-4wfhuvww	32	2	slippery	slippery	JJ
cord-291727-4wfhuvww	32	3	sequence	sequence	NN
cord-291727-4wfhuvww	32	4	of	of	IN
cord-291727-4wfhuvww	32	5	G	G	NNP
cord-291727-4wfhuvww	32	6	GGA	GGA	NNP
cord-291727-4wfhuvww	32	7	AAC	AAC	NNP
cord-291727-4wfhuvww	32	8	,	,	,
cord-291727-4wfhuvww	32	9	in	in	IN
cord-291727-4wfhuvww	32	10	combination	combination	NN
cord-291727-4wfhuvww	32	11	with	with	IN
cord-291727-4wfhuvww	32	12	a	a	DT
cord-291727-4wfhuvww	32	13	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	32	14	,	,	,
cord-291727-4wfhuvww	32	15	mediates	mediate	VBZ
cord-291727-4wfhuvww	32	16	highly	highly	RB
cord-291727-4wfhuvww	32	17	efficient	efficient	JJ
cord-291727-4wfhuvww	32	18	−1	−1	NNP
cord-291727-4wfhuvww	32	19	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	32	20	,	,	,
cord-291727-4wfhuvww	32	21	similar	similar	JJ
cord-291727-4wfhuvww	32	22	to	to	IN
cord-291727-4wfhuvww	32	23	viral	viral	JJ
cord-291727-4wfhuvww	32	24	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	32	25	motifs	motif	NNS
cord-291727-4wfhuvww	32	26	(	(	-LRB-
cord-291727-4wfhuvww	32	27	Clark	Clark	NNP
cord-291727-4wfhuvww	32	28	et	et	NNP
cord-291727-4wfhuvww	32	29	al	al	NNP
cord-291727-4wfhuvww	32	30	.	.	NNP
cord-291727-4wfhuvww	32	31	,	,	,
cord-291727-4wfhuvww	32	32	2007	2007	CD
cord-291727-4wfhuvww	32	33	)	)	-RRB-
cord-291727-4wfhuvww	32	34	.	.	.
cord-291727-4wfhuvww	33	1	Recently	recently	RB
cord-291727-4wfhuvww	33	2	,	,	,
cord-291727-4wfhuvww	33	3	a	a	DT
cord-291727-4wfhuvww	33	4	programmed	program	VBN
cord-291727-4wfhuvww	33	5	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	33	6	−1	−1	NNP
cord-291727-4wfhuvww	33	7	frameshift	frameshift	NN
cord-291727-4wfhuvww	33	8	has	have	VBZ
cord-291727-4wfhuvww	33	9	been	be	VBN
cord-291727-4wfhuvww	33	10	identified	identify	VBN
cord-291727-4wfhuvww	33	11	in	in	IN
cord-291727-4wfhuvww	33	12	the	the	DT
cord-291727-4wfhuvww	33	13	adenomatous	adenomatous	JJ
cord-291727-4wfhuvww	33	14	polyposis	polyposis	NN
cord-291727-4wfhuvww	33	15	coli	coli	NNS
cord-291727-4wfhuvww	33	16	(	(	-LRB-
cord-291727-4wfhuvww	33	17	APC	APC	NNP
cord-291727-4wfhuvww	33	18	)	)	-RRB-
cord-291727-4wfhuvww	33	19	mRNA	mrna	NN
cord-291727-4wfhuvww	33	20	in	in	IN
cord-291727-4wfhuvww	33	21	Caenorhabditis	Caenorhabditis	NNP
cord-291727-4wfhuvww	33	22	elegans	elegan	NNS
cord-291727-4wfhuvww	33	23	that	that	WDT
cord-291727-4wfhuvww	33	24	is	be	VBZ
cord-291727-4wfhuvww	33	25	mediated	mediate	VBN
cord-291727-4wfhuvww	33	26	by	by	IN
cord-291727-4wfhuvww	33	27	a	a	DT
cord-291727-4wfhuvww	33	28	slippery	slippery	JJ
cord-291727-4wfhuvww	33	29	sequence	sequence	NN
cord-291727-4wfhuvww	33	30	A	a	DT
cord-291727-4wfhuvww	33	31	AAA	AAA	NNP
cord-291727-4wfhuvww	33	32	AAA	aaa	NN
cord-291727-4wfhuvww	33	33	or	or	CC
cord-291727-4wfhuvww	33	34	A	a	DT
cord-291727-4wfhuvww	33	35	AAA	aaa	NN
cord-291727-4wfhuvww	33	36	AAC	aac	NN
cord-291727-4wfhuvww	34	1	(	(	-LRB-
cord-291727-4wfhuvww	34	2	Baranov	Baranov	NNP
cord-291727-4wfhuvww	34	3	et	et	NNP
cord-291727-4wfhuvww	34	4	al	al	NNP
cord-291727-4wfhuvww	34	5	.	.	NNP
cord-291727-4wfhuvww	34	6	,	,	,
cord-291727-4wfhuvww	34	7	2011	2011	CD
cord-291727-4wfhuvww	34	8	)	)	-RRB-
cord-291727-4wfhuvww	34	9	.	.	.
cord-291727-4wfhuvww	35	1	The	the	DT
cord-291727-4wfhuvww	35	2	functional	functional	JJ
cord-291727-4wfhuvww	35	3	relevance	relevance	NN
cord-291727-4wfhuvww	35	4	of	of	IN
cord-291727-4wfhuvww	35	5	this	this	DT
cord-291727-4wfhuvww	35	6	frameshift	frameshift	NN
cord-291727-4wfhuvww	35	7	is	be	VBZ
cord-291727-4wfhuvww	35	8	uncertain	uncertain	JJ
cord-291727-4wfhuvww	35	9	.	.	.
cord-291727-4wfhuvww	36	1	Although	although	IN
cord-291727-4wfhuvww	36	2	the	the	DT
cord-291727-4wfhuvww	36	3	slippery	slippery	JJ
cord-291727-4wfhuvww	36	4	sequence	sequence	NN
cord-291727-4wfhuvww	36	5	and	and	CC
cord-291727-4wfhuvww	36	6	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	36	7	are	be	VBP
cord-291727-4wfhuvww	36	8	the	the	DT
cord-291727-4wfhuvww	36	9	most	most	RBS
cord-291727-4wfhuvww	36	10	common	common	JJ
cord-291727-4wfhuvww	36	11	motifs	motif	NNS
cord-291727-4wfhuvww	36	12	for	for	IN
cord-291727-4wfhuvww	36	13	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	36	14	identified	identify	VBN
cord-291727-4wfhuvww	36	15	thus	thus	RB
cord-291727-4wfhuvww	36	16	far	far	RB
cord-291727-4wfhuvww	36	17	,	,	,
cord-291727-4wfhuvww	36	18	there	there	EX
cord-291727-4wfhuvww	36	19	are	be	VBP
cord-291727-4wfhuvww	36	20	alternative	alternative	JJ
cord-291727-4wfhuvww	36	21	mechanisms	mechanism	NNS
cord-291727-4wfhuvww	36	22	that	that	WDT
cord-291727-4wfhuvww	36	23	may	may	MD
cord-291727-4wfhuvww	36	24	result	result	VB
cord-291727-4wfhuvww	36	25	in	in	IN
cord-291727-4wfhuvww	36	26	the	the	DT
cord-291727-4wfhuvww	36	27	production	production	NN
cord-291727-4wfhuvww	36	28	of	of	IN
cord-291727-4wfhuvww	36	29	out	out	IN
cord-291727-4wfhuvww	36	30	-	-	HYPH
cord-291727-4wfhuvww	36	31	of	of	IN
cord-291727-4wfhuvww	36	32	-	-	HYPH
cord-291727-4wfhuvww	36	33	frame	frame	NN
cord-291727-4wfhuvww	36	34	proteins	protein	NNS
cord-291727-4wfhuvww	36	35	.	.	.
cord-291727-4wfhuvww	37	1	Alternative	alternative	JJ
cord-291727-4wfhuvww	37	2	splicing	splicing	NN
cord-291727-4wfhuvww	37	3	may	may	MD
cord-291727-4wfhuvww	37	4	contribute	contribute	VB
cord-291727-4wfhuvww	37	5	to	to	IN
cord-291727-4wfhuvww	37	6	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	37	7	(	(	-LRB-
cord-291727-4wfhuvww	37	8	Hiller	Hiller	NNP
cord-291727-4wfhuvww	37	9	et	et	NNP
cord-291727-4wfhuvww	37	10	al	al	NNP
cord-291727-4wfhuvww	37	11	.	.	NNP
cord-291727-4wfhuvww	37	12	,	,	,
cord-291727-4wfhuvww	37	13	2005	2005	CD
cord-291727-4wfhuvww	37	14	)	)	-RRB-
cord-291727-4wfhuvww	37	15	,	,	,
cord-291727-4wfhuvww	37	16	as	as	IN
cord-291727-4wfhuvww	37	17	can	can	MD
cord-291727-4wfhuvww	37	18	codon	codon	NN
cord-291727-4wfhuvww	37	19	bias	bias	NN
cord-291727-4wfhuvww	37	20	.	.	.
cord-291727-4wfhuvww	38	1	For	for	IN
cord-291727-4wfhuvww	38	2	instance	instance	NN
cord-291727-4wfhuvww	38	3	,	,	,
cord-291727-4wfhuvww	38	4	rare	rare	JJ
cord-291727-4wfhuvww	38	5	tRNA	tRNA	NNP
cord-291727-4wfhuvww	38	6	codons	codon	NNS
cord-291727-4wfhuvww	38	7	can	can	MD
cord-291727-4wfhuvww	38	8	favor	favor	VB
cord-291727-4wfhuvww	38	9	−1	−1	NNP
cord-291727-4wfhuvww	38	10	and	and	CC
cord-291727-4wfhuvww	38	11	+1	+1	NFP
cord-291727-4wfhuvww	38	12	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	38	13	(	(	-LRB-
cord-291727-4wfhuvww	38	14	Gurvich	Gurvich	NNP
cord-291727-4wfhuvww	38	15	et	et	NNP
cord-291727-4wfhuvww	38	16	al	al	NNP
cord-291727-4wfhuvww	38	17	.	.	NNP
cord-291727-4wfhuvww	38	18	,	,	,
cord-291727-4wfhuvww	38	19	2005	2005	CD
cord-291727-4wfhuvww	38	20	;	;	:
cord-291727-4wfhuvww	38	21	Laine	Laine	NNP
cord-291727-4wfhuvww	38	22	et	et	FW
cord-291727-4wfhuvww	38	23	al	al	NNP
cord-291727-4wfhuvww	38	24	.	.	NNP
cord-291727-4wfhuvww	38	25	,	,	,
cord-291727-4wfhuvww	38	26	2008	2008	CD
cord-291727-4wfhuvww	38	27	)	)	-RRB-
cord-291727-4wfhuvww	38	28	,	,	,
cord-291727-4wfhuvww	38	29	and	and	CC
cord-291727-4wfhuvww	38	30	rare	rare	JJ
cord-291727-4wfhuvww	38	31	arginine	arginine	NN
cord-291727-4wfhuvww	38	32	codons	codon	NNS
cord-291727-4wfhuvww	38	33	prime	prime	JJ
cord-291727-4wfhuvww	38	34	mitochondrial	mitochondrial	NN
cord-291727-4wfhuvww	38	35	sequences	sequence	NNS
cord-291727-4wfhuvww	38	36	for	for	IN
cord-291727-4wfhuvww	38	37	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	39	1	(	(	-LRB-
cord-291727-4wfhuvww	39	2	Temperley	Temperley	NNP
cord-291727-4wfhuvww	39	3	et	et	NNP
cord-291727-4wfhuvww	39	4	al	al	NNP
cord-291727-4wfhuvww	39	5	.	.	NNP
cord-291727-4wfhuvww	39	6	,	,	,
cord-291727-4wfhuvww	39	7	2010	2010	CD
cord-291727-4wfhuvww	39	8	)	)	-RRB-
cord-291727-4wfhuvww	39	9	.	.	.
cord-291727-4wfhuvww	40	1	Moreover	moreover	RB
cord-291727-4wfhuvww	40	2	,	,	,
cord-291727-4wfhuvww	40	3	CAG	CAG	NNP
cord-291727-4wfhuvww	40	4	repeats	repeat	VBZ
cord-291727-4wfhuvww	40	5	are	be	VBP
cord-291727-4wfhuvww	40	6	prone	prone	JJ
cord-291727-4wfhuvww	40	7	to	to	IN
cord-291727-4wfhuvww	40	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	40	9	,	,	,
cord-291727-4wfhuvww	40	10	which	which	WDT
cord-291727-4wfhuvww	40	11	results	result	VBZ
cord-291727-4wfhuvww	40	12	in	in	IN
cord-291727-4wfhuvww	40	13	poly	poly	JJ
cord-291727-4wfhuvww	40	14	-	-	HYPH
cord-291727-4wfhuvww	40	15	alanine	alanine	JJ
cord-291727-4wfhuvww	40	16	proteins	protein	NNS
cord-291727-4wfhuvww	40	17	that	that	WDT
cord-291727-4wfhuvww	40	18	may	may	MD
cord-291727-4wfhuvww	40	19	contribute	contribute	VB
cord-291727-4wfhuvww	40	20	to	to	IN
cord-291727-4wfhuvww	40	21	the	the	DT
cord-291727-4wfhuvww	40	22	pathogenesis	pathogenesis	NN
cord-291727-4wfhuvww	40	23	of	of	IN
cord-291727-4wfhuvww	40	24	neurodegenerative	neurodegenerative	JJ
cord-291727-4wfhuvww	40	25	diseases	disease	NNS
cord-291727-4wfhuvww	40	26	(	(	-LRB-
cord-291727-4wfhuvww	40	27	Toulouse	Toulouse	NNP
cord-291727-4wfhuvww	40	28	et	et	NNP
cord-291727-4wfhuvww	40	29	al	al	NNP
cord-291727-4wfhuvww	40	30	.	.	NNP
cord-291727-4wfhuvww	40	31	,	,	,
cord-291727-4wfhuvww	40	32	2005	2005	CD
cord-291727-4wfhuvww	40	33	)	)	-RRB-
cord-291727-4wfhuvww	40	34	.	.	.
cord-291727-4wfhuvww	41	1	The	the	DT
cord-291727-4wfhuvww	41	2	use	use	NN
cord-291727-4wfhuvww	41	3	of	of	IN
cord-291727-4wfhuvww	41	4	the	the	DT
cord-291727-4wfhuvww	41	5	peptidyltransferase	peptidyltransferase	NNP
cord-291727-4wfhuvww	41	6	inhibitor	inhibitor	NNP
cord-291727-4wfhuvww	41	7	anisomycin	anisomycin	NNP
cord-291727-4wfhuvww	41	8	reduces	reduce	VBZ
cord-291727-4wfhuvww	41	9	−1	−1	NNP
cord-291727-4wfhuvww	41	10	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	41	11	in	in	IN
cord-291727-4wfhuvww	41	12	these	these	DT
cord-291727-4wfhuvww	41	13	cases	case	NNS
cord-291727-4wfhuvww	41	14	and	and	CC
cord-291727-4wfhuvww	41	15	reduces	reduce	VBZ
cord-291727-4wfhuvww	41	16	the	the	DT
cord-291727-4wfhuvww	41	17	toxicity	toxicity	NN
cord-291727-4wfhuvww	41	18	associated	associate	VBN
cord-291727-4wfhuvww	41	19	with	with	IN
cord-291727-4wfhuvww	41	20	the	the	DT
cord-291727-4wfhuvww	41	21	expanded	expand	VBN
cord-291727-4wfhuvww	41	22	triplet	triplet	NN
cord-291727-4wfhuvww	41	23	repeats	repeat	VBZ
cord-291727-4wfhuvww	41	24	.	.	.
cord-291727-4wfhuvww	42	1	Importantly	importantly	RB
cord-291727-4wfhuvww	42	2	,	,	,
cord-291727-4wfhuvww	42	3	out	out	RB
cord-291727-4wfhuvww	42	4	-	-	HYPH
cord-291727-4wfhuvww	42	5	of	of	IN
cord-291727-4wfhuvww	42	6	-	-	HYPH
cord-291727-4wfhuvww	42	7	frame	frame	NN
cord-291727-4wfhuvww	42	8	proteins	protein	NNS
cord-291727-4wfhuvww	42	9	(	(	-LRB-
cord-291727-4wfhuvww	42	10	compared	compare	VBN
cord-291727-4wfhuvww	42	11	to	to	IN
cord-291727-4wfhuvww	42	12	the	the	DT
cord-291727-4wfhuvww	42	13	standard	standard	JJ
cord-291727-4wfhuvww	42	14	ORFeome	orfeome	NN
cord-291727-4wfhuvww	42	15	annotation	annotation	NN
cord-291727-4wfhuvww	42	16	)	)	-RRB-
cord-291727-4wfhuvww	42	17	can	can	MD
cord-291727-4wfhuvww	42	18	also	also	RB
cord-291727-4wfhuvww	42	19	result	result	VB
cord-291727-4wfhuvww	42	20	from	from	IN
cord-291727-4wfhuvww	42	21	alternative	alternative	JJ
cord-291727-4wfhuvww	42	22	AUG	AUG	NNP
cord-291727-4wfhuvww	42	23	or	or	CC
cord-291727-4wfhuvww	42	24	CUG	CUG	NNP
cord-291727-4wfhuvww	42	25	start	start	VBP
cord-291727-4wfhuvww	42	26	sites	site	NNS
cord-291727-4wfhuvww	42	27	(	(	-LRB-
cord-291727-4wfhuvww	42	28	Ingolia	Ingolia	NNP
cord-291727-4wfhuvww	42	29	et	et	NNP
cord-291727-4wfhuvww	42	30	al	al	NNP
cord-291727-4wfhuvww	42	31	.	.	NNP
cord-291727-4wfhuvww	42	32	,	,	,
cord-291727-4wfhuvww	42	33	2011	2011	CD
cord-291727-4wfhuvww	42	34	)	)	-RRB-
cord-291727-4wfhuvww	42	35	,	,	,
cord-291727-4wfhuvww	42	36	thereby	thereby	RB
cord-291727-4wfhuvww	42	37	considerably	considerably	RB
cord-291727-4wfhuvww	42	38	increasing	increase	VBG
cord-291727-4wfhuvww	42	39	the	the	DT
cord-291727-4wfhuvww	42	40	size	size	NN
cord-291727-4wfhuvww	42	41	of	of	IN
cord-291727-4wfhuvww	42	42	an	an	DT
cord-291727-4wfhuvww	42	43	alternative	alternative	JJ
cord-291727-4wfhuvww	42	44	"	"	``
cord-291727-4wfhuvww	42	45	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	42	46	"	"	''
cord-291727-4wfhuvww	42	47	proteome	proteome	NN
cord-291727-4wfhuvww	42	48	.	.	.
cord-291727-4wfhuvww	43	1	Main	main	JJ
cord-291727-4wfhuvww	43	2	sources	source	NNS
cord-291727-4wfhuvww	43	3	of	of	IN
cord-291727-4wfhuvww	43	4	out	out	IN
cord-291727-4wfhuvww	43	5	-	-	HYPH
cord-291727-4wfhuvww	43	6	of	of	IN
cord-291727-4wfhuvww	43	7	-	-	HYPH
cord-291727-4wfhuvww	43	8	frame	frame	NN
cord-291727-4wfhuvww	43	9	peptides	peptide	NNS
cord-291727-4wfhuvww	43	10	and	and	CC
cord-291727-4wfhuvww	43	11	proteins	protein	NNS
cord-291727-4wfhuvww	43	12	are	be	VBP
cord-291727-4wfhuvww	43	13	shown	show	VBN
cord-291727-4wfhuvww	43	14	in	in	IN
cord-291727-4wfhuvww	43	15	Figure	figure	NN
cord-291727-4wfhuvww	43	16	2	2	CD
cord-291727-4wfhuvww	43	17	.	.	.
cord-291727-4wfhuvww	44	1	An	an	DT
cord-291727-4wfhuvww	44	2	interesting	interesting	JJ
cord-291727-4wfhuvww	44	3	example	example	NN
cord-291727-4wfhuvww	44	4	of	of	IN
cord-291727-4wfhuvww	44	5	programmed	program	VBN
cord-291727-4wfhuvww	44	6	ribosomal	ribosomal	NN
cord-291727-4wfhuvww	44	7	+1	+1	NN
cord-291727-4wfhuvww	44	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	44	9	is	be	VBZ
cord-291727-4wfhuvww	44	10	that	that	DT
cord-291727-4wfhuvww	44	11	of	of	IN
cord-291727-4wfhuvww	44	12	the	the	DT
cord-291727-4wfhuvww	44	13	ornithine	ornithine	NN
cord-291727-4wfhuvww	44	14	decarboxylase	decarboxylase	NN
cord-291727-4wfhuvww	44	15	(	(	-LRB-
cord-291727-4wfhuvww	44	16	ODC	ODC	NNP
cord-291727-4wfhuvww	44	17	)	)	-RRB-
cord-291727-4wfhuvww	44	18	gene	gene	NN
cord-291727-4wfhuvww	44	19	that	that	WDT
cord-291727-4wfhuvww	44	20	produces	produce	VBZ
cord-291727-4wfhuvww	44	21	the	the	DT
cord-291727-4wfhuvww	44	22	antizyme	antizyme	NNS
cord-291727-4wfhuvww	44	23	from	from	IN
cord-291727-4wfhuvww	44	24	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	44	25	of	of	IN
cord-291727-4wfhuvww	44	26	the	the	DT
cord-291727-4wfhuvww	44	27	mRNA	mRNA	NNP
cord-291727-4wfhuvww	44	28	sequence	sequence	NN
cord-291727-4wfhuvww	44	29	(	(	-LRB-
cord-291727-4wfhuvww	44	30	Bekaert	Bekaert	NNP
cord-291727-4wfhuvww	44	31	et	et	NNP
cord-291727-4wfhuvww	44	32	al	al	NNP
cord-291727-4wfhuvww	44	33	.	.	NNP
cord-291727-4wfhuvww	44	34	,	,	,
cord-291727-4wfhuvww	44	35	2008	2008	CD
cord-291727-4wfhuvww	44	36	)	)	-RRB-
cord-291727-4wfhuvww	44	37	.	.	.
cord-291727-4wfhuvww	45	1	ODC	ODC	NNP
cord-291727-4wfhuvww	45	2	catalyzes	catalyze	VBZ
cord-291727-4wfhuvww	45	3	the	the	DT
cord-291727-4wfhuvww	45	4	production	production	NN
cord-291727-4wfhuvww	45	5	of	of	IN
cord-291727-4wfhuvww	45	6	polyamines	polyamine	NNS
cord-291727-4wfhuvww	45	7	,	,	,
cord-291727-4wfhuvww	45	8	such	such	JJ
cord-291727-4wfhuvww	45	9	as	as	IN
cord-291727-4wfhuvww	45	10	putrescine	putrescine	NN
cord-291727-4wfhuvww	45	11	,	,	,
cord-291727-4wfhuvww	45	12	spermidine	spermidine	NNP
cord-291727-4wfhuvww	45	13	,	,	,
cord-291727-4wfhuvww	45	14	and	and	CC
cord-291727-4wfhuvww	45	15	spermine	spermine	VB
cord-291727-4wfhuvww	45	16	from	from	IN
cord-291727-4wfhuvww	45	17	ornithine	ornithine	NN
cord-291727-4wfhuvww	45	18	through	through	IN
cord-291727-4wfhuvww	45	19	decarboxylation	decarboxylation	NN
cord-291727-4wfhuvww	45	20	.	.	.
cord-291727-4wfhuvww	46	1	ODC	ODC	NNP
cord-291727-4wfhuvww	46	2	activity	activity	NN
cord-291727-4wfhuvww	46	3	is	be	VBZ
cord-291727-4wfhuvww	46	4	terminated	terminate	VBN
cord-291727-4wfhuvww	46	5	by	by	IN
cord-291727-4wfhuvww	46	6	the	the	DT
cord-291727-4wfhuvww	46	7	antizyme	antizyme	NNS
cord-291727-4wfhuvww	46	8	(	(	-LRB-
cord-291727-4wfhuvww	46	9	Murakami	Murakami	NNP
cord-291727-4wfhuvww	46	10	et	et	FW
cord-291727-4wfhuvww	46	11	al	al	NNP
cord-291727-4wfhuvww	46	12	.	.	.
cord-291727-4wfhuvww	47	1	,	,	,
cord-291727-4wfhuvww	47	2	1992	1992	CD
cord-291727-4wfhuvww	47	3	)	)	-RRB-
cord-291727-4wfhuvww	48	1	-providing	-provide	VBG
cord-291727-4wfhuvww	48	2	an	an	DT
cord-291727-4wfhuvww	48	3	elegant	elegant	JJ
cord-291727-4wfhuvww	48	4	mechanism	mechanism	NN
cord-291727-4wfhuvww	48	5	for	for	IN
cord-291727-4wfhuvww	48	6	shutting	shut	VBG
cord-291727-4wfhuvww	48	7	down	down	RP
cord-291727-4wfhuvww	48	8	the	the	DT
cord-291727-4wfhuvww	48	9	activity	activity	NN
cord-291727-4wfhuvww	48	10	of	of	IN
cord-291727-4wfhuvww	48	11	an	an	DT
cord-291727-4wfhuvww	48	12	enzyme	enzyme	NN
cord-291727-4wfhuvww	48	13	by	by	IN
cord-291727-4wfhuvww	48	14	producing	produce	VBG
cord-291727-4wfhuvww	48	15	an	an	DT
cord-291727-4wfhuvww	48	16	out	out	IN
cord-291727-4wfhuvww	48	17	-	-	HYPH
cord-291727-4wfhuvww	48	18	of	of	IN
cord-291727-4wfhuvww	48	19	-	-	HYPH
cord-291727-4wfhuvww	48	20	frame	frame	NN
cord-291727-4wfhuvww	48	21	antizyme	antizyme	NNS
cord-291727-4wfhuvww	48	22	from	from	IN
cord-291727-4wfhuvww	48	23	the	the	DT
cord-291727-4wfhuvww	48	24	same	same	JJ
cord-291727-4wfhuvww	48	25	mRNA	mrna	NN
cord-291727-4wfhuvww	48	26	.	.	.
cord-291727-4wfhuvww	49	1	This	this	DT
cord-291727-4wfhuvww	49	2	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	49	3	is	be	VBZ
cord-291727-4wfhuvww	49	4	tightly	tightly	RB
cord-291727-4wfhuvww	49	5	regulated	regulate	VBN
cord-291727-4wfhuvww	49	6	and	and	CC
cord-291727-4wfhuvww	49	7	can	can	MD
cord-291727-4wfhuvww	49	8	be	be	VB
cord-291727-4wfhuvww	49	9	enhanced	enhance	VBN
cord-291727-4wfhuvww	49	10	by	by	IN
cord-291727-4wfhuvww	49	11	treatment	treatment	NN
cord-291727-4wfhuvww	49	12	of	of	IN
cord-291727-4wfhuvww	49	13	cells	cell	NNS
cord-291727-4wfhuvww	49	14	with	with	IN
cord-291727-4wfhuvww	49	15	polyamines	polyamine	NNS
cord-291727-4wfhuvww	49	16	(	(	-LRB-
cord-291727-4wfhuvww	49	17	Nilsson	Nilsson	NNP
cord-291727-4wfhuvww	49	18	et	et	NNP
cord-291727-4wfhuvww	49	19	al	al	NNP
cord-291727-4wfhuvww	49	20	.	.	NNP
cord-291727-4wfhuvww	49	21	,	,	,
cord-291727-4wfhuvww	49	22	1997	1997	CD
cord-291727-4wfhuvww	49	23	)	)	-RRB-
cord-291727-4wfhuvww	49	24	.	.	.
cord-291727-4wfhuvww	50	1	The	the	DT
cord-291727-4wfhuvww	50	2	ODC	ODC	NNP
cord-291727-4wfhuvww	50	3	antizyme	antizyme	NNS
cord-291727-4wfhuvww	50	4	mechanism	mechanism	NN
cord-291727-4wfhuvww	50	5	is	be	VBZ
cord-291727-4wfhuvww	50	6	highly	highly	RB
cord-291727-4wfhuvww	50	7	conserved	conserve	VBN
cord-291727-4wfhuvww	50	8	throughout	throughout	IN
cord-291727-4wfhuvww	50	9	all	all	DT
cord-291727-4wfhuvww	50	10	eukaryotes	eukaryote	NNS
cord-291727-4wfhuvww	50	11	(	(	-LRB-
cord-291727-4wfhuvww	50	12	Ivanov	Ivanov	NNP
cord-291727-4wfhuvww	50	13	et	et	NNP
cord-291727-4wfhuvww	50	14	al	al	NNP
cord-291727-4wfhuvww	50	15	.	.	NNP
cord-291727-4wfhuvww	50	16	,	,	,
cord-291727-4wfhuvww	50	17	2000b	2000b	CD
cord-291727-4wfhuvww	50	18	)	)	-RRB-
cord-291727-4wfhuvww	50	19	.	.	.
cord-291727-4wfhuvww	51	1	The	the	DT
cord-291727-4wfhuvww	51	2	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	51	3	requires	require	VBZ
cord-291727-4wfhuvww	51	4	the	the	DT
cord-291727-4wfhuvww	51	5	FIGURE	figure	NN
cord-291727-4wfhuvww	51	6	2	2	CD
cord-291727-4wfhuvww	51	7	|	|	NNP
cord-291727-4wfhuvww	51	8	Main	main	JJ
cord-291727-4wfhuvww	51	9	sources	source	NNS
cord-291727-4wfhuvww	51	10	for	for	IN
cord-291727-4wfhuvww	51	11	out	out	RB
cord-291727-4wfhuvww	51	12	-	-	HYPH
cord-291727-4wfhuvww	51	13	of	of	IN
cord-291727-4wfhuvww	51	14	-	-	HYPH
cord-291727-4wfhuvww	51	15	frame	frame	NN
cord-291727-4wfhuvww	51	16	peptides	peptide	NNS
cord-291727-4wfhuvww	51	17	.	.	.
cord-291727-4wfhuvww	52	1	Regular	regular	JJ
cord-291727-4wfhuvww	52	2	expression	expression	NN
cord-291727-4wfhuvww	52	3	of	of	IN
cord-291727-4wfhuvww	52	4	this	this	DT
cord-291727-4wfhuvww	52	5	mRNA	mrna	NN
cord-291727-4wfhuvww	52	6	with	with	IN
cord-291727-4wfhuvww	52	7	translation	translation	NN
cord-291727-4wfhuvww	52	8	initiating	initiate	VBG
cord-291727-4wfhuvww	52	9	tRNAmet	trnamet	PRP
cord-291727-4wfhuvww	52	10	will	will	MD
cord-291727-4wfhuvww	52	11	result	result	VB
cord-291727-4wfhuvww	52	12	in	in	IN
cord-291727-4wfhuvww	52	13	expression	expression	NN
cord-291727-4wfhuvww	52	14	of	of	IN
cord-291727-4wfhuvww	52	15	peptide	peptide	NN
cord-291727-4wfhuvww	52	16	"	"	''
cord-291727-4wfhuvww	52	17	AUG(0	aug(0	NN
cord-291727-4wfhuvww	52	18	)	)	-RRB-
cord-291727-4wfhuvww	52	19	"	"	''
cord-291727-4wfhuvww	53	1	(	(	-LRB-
cord-291727-4wfhuvww	53	2	red	red	NNP
cord-291727-4wfhuvww	53	3	)	)	-RRB-
cord-291727-4wfhuvww	53	4	.	.	.
cord-291727-4wfhuvww	54	1	Out	out	IN
cord-291727-4wfhuvww	54	2	-	-	HYPH
cord-291727-4wfhuvww	54	3	of	of	IN
cord-291727-4wfhuvww	54	4	-	-	HYPH
cord-291727-4wfhuvww	54	5	frame	frame	NN
cord-291727-4wfhuvww	54	6	peptides	peptide	NNS
cord-291727-4wfhuvww	54	7	could	could	MD
cord-291727-4wfhuvww	54	8	arise	arise	VB
cord-291727-4wfhuvww	54	9	from	from	IN
cord-291727-4wfhuvww	54	10	alternative	alternative	JJ
cord-291727-4wfhuvww	54	11	out	out	RB
cord-291727-4wfhuvww	54	12	-	-	HYPH
cord-291727-4wfhuvww	54	13	of	of	IN
cord-291727-4wfhuvww	54	14	-	-	HYPH
cord-291727-4wfhuvww	54	15	frame	frame	NN
cord-291727-4wfhuvww	54	16	CUG	CUG	NNP
cord-291727-4wfhuvww	54	17	or	or	CC
cord-291727-4wfhuvww	54	18	AUG	AUG	NNP
cord-291727-4wfhuvww	54	19	start	start	NN
cord-291727-4wfhuvww	54	20	sites	site	NNS
cord-291727-4wfhuvww	54	21	resulting	result	VBG
cord-291727-4wfhuvww	54	22	in	in	IN
cord-291727-4wfhuvww	54	23	translation	translation	NN
cord-291727-4wfhuvww	54	24	of	of	IN
cord-291727-4wfhuvww	54	25	peptide	peptide	NN
cord-291727-4wfhuvww	54	26	"	"	``
cord-291727-4wfhuvww	54	27	CUG(−1	cug(−1	$
cord-291727-4wfhuvww	54	28	)	)	-RRB-
cord-291727-4wfhuvww	55	1	"	"	``
cord-291727-4wfhuvww	55	2	(	(	-LRB-
cord-291727-4wfhuvww	55	3	green	green	JJ
cord-291727-4wfhuvww	55	4	)	)	-RRB-
cord-291727-4wfhuvww	55	5	.	.	.
cord-291727-4wfhuvww	56	1	Alternatively	alternatively	RB
cord-291727-4wfhuvww	56	2	,	,	,
cord-291727-4wfhuvww	56	3	−1	−1	NNP
cord-291727-4wfhuvww	56	4	or	or	CC
cord-291727-4wfhuvww	56	5	+1	+1	HYPH
cord-291727-4wfhuvww	56	6	frameshift	frameshift	NN
cord-291727-4wfhuvww	56	7	signals	signal	NNS
cord-291727-4wfhuvww	56	8	within	within	IN
cord-291727-4wfhuvww	56	9	the	the	DT
cord-291727-4wfhuvww	56	10	original	original	JJ
cord-291727-4wfhuvww	56	11	reading	reading	NN
cord-291727-4wfhuvww	56	12	frame	frame	NN
cord-291727-4wfhuvww	56	13	could	could	MD
cord-291727-4wfhuvww	56	14	result	result	VB
cord-291727-4wfhuvww	56	15	in	in	IN
cord-291727-4wfhuvww	56	16	expression	expression	NN
cord-291727-4wfhuvww	56	17	of	of	IN
cord-291727-4wfhuvww	56	18	out	out	IN
cord-291727-4wfhuvww	56	19	-	-	HYPH
cord-291727-4wfhuvww	56	20	of	of	IN
cord-291727-4wfhuvww	56	21	-	-	HYPH
cord-291727-4wfhuvww	56	22	frame	frame	NN
cord-291727-4wfhuvww	56	23	peptides	peptide	NNS
cord-291727-4wfhuvww	56	24	"	"	``
cord-291727-4wfhuvww	56	25	AUG(−1	aug(−1	JJ
cord-291727-4wfhuvww	56	26	)	)	-RRB-
cord-291727-4wfhuvww	56	27	"	"	''
cord-291727-4wfhuvww	56	28	(	(	-LRB-
cord-291727-4wfhuvww	56	29	blue	blue	JJ
cord-291727-4wfhuvww	56	30	)	)	-RRB-
cord-291727-4wfhuvww	56	31	or	or	CC
cord-291727-4wfhuvww	56	32	"	"	``
cord-291727-4wfhuvww	56	33	AUG(+1	aug(+1	NN
cord-291727-4wfhuvww	56	34	)	)	-RRB-
cord-291727-4wfhuvww	56	35	"	"	''
cord-291727-4wfhuvww	56	36	(	(	-LRB-
cord-291727-4wfhuvww	56	37	yellow	yellow	NNP
cord-291727-4wfhuvww	56	38	)	)	-RRB-
cord-291727-4wfhuvww	56	39	,	,	,
cord-291727-4wfhuvww	56	40	respectively	respectively	RB
cord-291727-4wfhuvww	56	41	.	.	.
cord-291727-4wfhuvww	57	1	UGA	UGA	NNP
cord-291727-4wfhuvww	57	2	stop	stop	VBP
cord-291727-4wfhuvww	57	3	codon	codon	NN
cord-291727-4wfhuvww	57	4	and	and	CC
cord-291727-4wfhuvww	57	5	a	a	DT
cord-291727-4wfhuvww	57	6	3	3	CD
cord-291727-4wfhuvww	57	7	stem	stem	NN
cord-291727-4wfhuvww	57	8	loop	loop	NN
cord-291727-4wfhuvww	57	9	that	that	WDT
cord-291727-4wfhuvww	57	10	forms	form	VBZ
cord-291727-4wfhuvww	57	11	a	a	DT
cord-291727-4wfhuvww	57	12	RNA	RNA	NNP
cord-291727-4wfhuvww	57	13	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	57	14	.	.	.
cord-291727-4wfhuvww	58	1	These	these	DT
cord-291727-4wfhuvww	58	2	RNA	RNA	NNP
cord-291727-4wfhuvww	58	3	hallmarks	hallmark	NNS
cord-291727-4wfhuvww	58	4	are	be	VBP
cord-291727-4wfhuvww	58	5	still	still	RB
cord-291727-4wfhuvww	58	6	the	the	DT
cord-291727-4wfhuvww	58	7	standard	standard	JJ
cord-291727-4wfhuvww	58	8	way	way	NN
cord-291727-4wfhuvww	58	9	to	to	TO
cord-291727-4wfhuvww	58	10	identify	identify	VB
cord-291727-4wfhuvww	58	11	other	other	JJ
cord-291727-4wfhuvww	58	12	+1	+1	HYPH
cord-291727-4wfhuvww	58	13	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	58	14	proteins	protein	NNS
cord-291727-4wfhuvww	58	15	.	.	.
cord-291727-4wfhuvww	59	1	It	-PRON-	PRP
cord-291727-4wfhuvww	59	2	has	have	VBZ
cord-291727-4wfhuvww	59	3	been	be	VBN
cord-291727-4wfhuvww	59	4	proposed	propose	VBN
cord-291727-4wfhuvww	59	5	that	that	IN
cord-291727-4wfhuvww	59	6	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	59	7	is	be	VBZ
cord-291727-4wfhuvww	59	8	a	a	DT
cord-291727-4wfhuvww	59	9	common	common	JJ
cord-291727-4wfhuvww	59	10	mechanism	mechanism	NN
cord-291727-4wfhuvww	59	11	to	to	TO
cord-291727-4wfhuvww	59	12	increase	increase	VB
cord-291727-4wfhuvww	59	13	protein	protein	NN
cord-291727-4wfhuvww	59	14	-	-	HYPH
cord-291727-4wfhuvww	59	15	coding	code	VBG
cord-291727-4wfhuvww	59	16	capacity	capacity	NN
cord-291727-4wfhuvww	59	17	of	of	IN
cord-291727-4wfhuvww	59	18	small	small	JJ
cord-291727-4wfhuvww	59	19	genomes	genome	NNS
cord-291727-4wfhuvww	59	20	such	such	JJ
cord-291727-4wfhuvww	59	21	as	as	IN
cord-291727-4wfhuvww	59	22	those	those	DT
cord-291727-4wfhuvww	59	23	of	of	IN
cord-291727-4wfhuvww	59	24	viruses	virus	NNS
cord-291727-4wfhuvww	59	25	and	and	CC
cord-291727-4wfhuvww	59	26	mitochondria	mitochondrion	NNS
cord-291727-4wfhuvww	59	27	.	.	.
cord-291727-4wfhuvww	60	1	In	in	IN
cord-291727-4wfhuvww	60	2	agreement	agreement	NN
cord-291727-4wfhuvww	60	3	with	with	IN
cord-291727-4wfhuvww	60	4	this	this	DT
cord-291727-4wfhuvww	60	5	proposal	proposal	NN
cord-291727-4wfhuvww	60	6	,	,	,
cord-291727-4wfhuvww	60	7	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	60	8	is	be	VBZ
cord-291727-4wfhuvww	60	9	common	common	JJ
cord-291727-4wfhuvww	60	10	in	in	IN
cord-291727-4wfhuvww	60	11	mitochondrial	mitochondrial	JJ
cord-291727-4wfhuvww	60	12	genes	gene	NNS
cord-291727-4wfhuvww	60	13	,	,	,
cord-291727-4wfhuvww	60	14	and	and	CC
cord-291727-4wfhuvww	60	15	genome	genome	NN
cord-291727-4wfhuvww	60	16	size	size	NN
cord-291727-4wfhuvww	60	17	seems	seem	VBZ
cord-291727-4wfhuvww	60	18	to	to	TO
cord-291727-4wfhuvww	60	19	correlate	correlate	VB
cord-291727-4wfhuvww	60	20	with	with	IN
cord-291727-4wfhuvww	60	21	the	the	DT
cord-291727-4wfhuvww	60	22	abundance	abundance	NN
cord-291727-4wfhuvww	60	23	of	of	IN
cord-291727-4wfhuvww	60	24	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	60	25	(	(	-LRB-
cord-291727-4wfhuvww	60	26	Seligmann	Seligmann	NNP
cord-291727-4wfhuvww	60	27	,	,	,
cord-291727-4wfhuvww	60	28	2010	2010	CD
cord-291727-4wfhuvww	60	29	)	)	-RRB-
cord-291727-4wfhuvww	60	30	.	.	.
cord-291727-4wfhuvww	61	1	In	in	IN
cord-291727-4wfhuvww	61	2	fact	fact	NN
cord-291727-4wfhuvww	61	3	,	,	,
cord-291727-4wfhuvww	61	4	some	some	DT
cord-291727-4wfhuvww	61	5	organisms	organism	NNS
cord-291727-4wfhuvww	61	6	display	display	VBP
cord-291727-4wfhuvww	61	7	a	a	DT
cord-291727-4wfhuvww	61	8	high	high	JJ
cord-291727-4wfhuvww	61	9	complexity	complexity	NN
cord-291727-4wfhuvww	61	10	in	in	IN
cord-291727-4wfhuvww	61	11	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	61	12	:	:	:
cord-291727-4wfhuvww	62	1	In	in	IN
cord-291727-4wfhuvww	62	2	the	the	DT
cord-291727-4wfhuvww	62	3	dinoflagellate	dinoflagellate	NN
cord-291727-4wfhuvww	62	4	Perkinsus	Perkinsus	NNP
cord-291727-4wfhuvww	62	5	marinus	marinus	NNP
cord-291727-4wfhuvww	62	6	,	,	,
cord-291727-4wfhuvww	62	7	the	the	DT
cord-291727-4wfhuvww	62	8	mitochondrial	mitochondrial	JJ
cord-291727-4wfhuvww	62	9	gene	gene	NN
cord-291727-4wfhuvww	62	10	that	that	WDT
cord-291727-4wfhuvww	62	11	encodes	encode	VBZ
cord-291727-4wfhuvww	62	12	cytochrome	cytochrome	NN
cord-291727-4wfhuvww	62	13	c	c	NN
cord-291727-4wfhuvww	62	14	oxidase	oxidase	NN
cord-291727-4wfhuvww	62	15	subunit	subunit	NN
cord-291727-4wfhuvww	62	16	1	1	CD
cord-291727-4wfhuvww	62	17	can	can	MD
cord-291727-4wfhuvww	62	18	shift	shift	VB
cord-291727-4wfhuvww	62	19	up	up	IN
cord-291727-4wfhuvww	62	20	to	to	TO
cord-291727-4wfhuvww	62	21	10	10	CD
cord-291727-4wfhuvww	62	22	times	time	NNS
cord-291727-4wfhuvww	62	23	within	within	IN
cord-291727-4wfhuvww	62	24	the	the	DT
cord-291727-4wfhuvww	62	25	same	same	JJ
cord-291727-4wfhuvww	62	26	mRNA	mRNA	NNP
cord-291727-4wfhuvww	62	27	sequence	sequence	NN
cord-291727-4wfhuvww	62	28	in	in	IN
cord-291727-4wfhuvww	62	29	order	order	NN
cord-291727-4wfhuvww	62	30	to	to	TO
cord-291727-4wfhuvww	62	31	produce	produce	VB
cord-291727-4wfhuvww	62	32	the	the	DT
cord-291727-4wfhuvww	62	33	correct	correct	JJ
cord-291727-4wfhuvww	62	34	gene	gene	NN
cord-291727-4wfhuvww	62	35	product	product	NN
cord-291727-4wfhuvww	62	36	(	(	-LRB-
cord-291727-4wfhuvww	62	37	Masuda	Masuda	NNP
cord-291727-4wfhuvww	62	38	et	et	FW
cord-291727-4wfhuvww	62	39	al	al	NNP
cord-291727-4wfhuvww	62	40	.	.	NNP
cord-291727-4wfhuvww	62	41	,	,	,
cord-291727-4wfhuvww	62	42	2010	2010	CD
cord-291727-4wfhuvww	62	43	)	)	-RRB-
cord-291727-4wfhuvww	62	44	.	.	.
cord-291727-4wfhuvww	63	1	Clearly	clearly	RB
cord-291727-4wfhuvww	63	2	,	,	,
cord-291727-4wfhuvww	63	3	such	such	JJ
cord-291727-4wfhuvww	63	4	complex	complex	JJ
cord-291727-4wfhuvww	63	5	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	63	6	requires	require	VBZ
cord-291727-4wfhuvww	63	7	efficient	efficient	JJ
cord-291727-4wfhuvww	63	8	regulatory	regulatory	JJ
cord-291727-4wfhuvww	63	9	control	control	NN
cord-291727-4wfhuvww	63	10	.	.	.
cord-291727-4wfhuvww	64	1	There	there	EX
cord-291727-4wfhuvww	64	2	is	be	VBZ
cord-291727-4wfhuvww	64	3	increasing	increase	VBG
cord-291727-4wfhuvww	64	4	evidence	evidence	NN
cord-291727-4wfhuvww	64	5	that	that	IN
cord-291727-4wfhuvww	64	6	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	64	7	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	64	8	is	be	VBZ
cord-291727-4wfhuvww	64	9	a	a	DT
cord-291727-4wfhuvww	64	10	regulated	regulated	JJ
cord-291727-4wfhuvww	64	11	event	event	NN
cord-291727-4wfhuvww	64	12	.	.	.
cord-291727-4wfhuvww	65	1	Several	several	JJ
cord-291727-4wfhuvww	65	2	enzymatic	enzymatic	JJ
cord-291727-4wfhuvww	65	3	and	and	CC
cord-291727-4wfhuvww	65	4	non	non	JJ
cord-291727-4wfhuvww	65	5	-	-	JJ
cord-291727-4wfhuvww	65	6	enzymatic	enzymatic	JJ
cord-291727-4wfhuvww	65	7	mechanisms	mechanism	NNS
cord-291727-4wfhuvww	65	8	have	have	VBP
cord-291727-4wfhuvww	65	9	been	be	VBN
cord-291727-4wfhuvww	65	10	proposed	propose	VBN
cord-291727-4wfhuvww	65	11	that	that	DT
cord-291727-4wfhuvww	65	12	result	result	NN
cord-291727-4wfhuvww	65	13	in	in	IN
cord-291727-4wfhuvww	65	14	an	an	DT
cord-291727-4wfhuvww	65	15	enhancement	enhancement	NN
cord-291727-4wfhuvww	65	16	of	of	IN
cord-291727-4wfhuvww	65	17	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	65	18	.	.	.
cord-291727-4wfhuvww	66	1	For	for	IN
cord-291727-4wfhuvww	66	2	instance	instance	NN
cord-291727-4wfhuvww	66	3	,	,	,
cord-291727-4wfhuvww	66	4	the	the	DT
cord-291727-4wfhuvww	66	5	production	production	NN
cord-291727-4wfhuvww	66	6	of	of	IN
cord-291727-4wfhuvww	66	7	antizyme	antizyme	NNS
cord-291727-4wfhuvww	66	8	by	by	IN
cord-291727-4wfhuvww	66	9	+1	+1	NNP
cord-291727-4wfhuvww	66	10	frameshifting	frameshifting	NNP
cord-291727-4wfhuvww	66	11	is	be	VBZ
cord-291727-4wfhuvww	66	12	enhanced	enhance	VBN
cord-291727-4wfhuvww	66	13	by	by	IN
cord-291727-4wfhuvww	66	14	the	the	DT
cord-291727-4wfhuvww	66	15	end	end	NN
cord-291727-4wfhuvww	66	16	-	-	HYPH
cord-291727-4wfhuvww	66	17	products	product	NNS
cord-291727-4wfhuvww	66	18	of	of	IN
cord-291727-4wfhuvww	66	19	ODC	ODC	NNP
cord-291727-4wfhuvww	66	20	-	-	HYPH
cord-291727-4wfhuvww	66	21	spermine	spermine	NNP
cord-291727-4wfhuvww	66	22	,	,	,
cord-291727-4wfhuvww	66	23	putrescine	putrescine	NN
cord-291727-4wfhuvww	66	24	,	,	,
cord-291727-4wfhuvww	66	25	and	and	CC
cord-291727-4wfhuvww	66	26	spermidine	spermidine	NNP
cord-291727-4wfhuvww	66	27	(	(	-LRB-
cord-291727-4wfhuvww	66	28	Ivanov	Ivanov	NNP
cord-291727-4wfhuvww	66	29	et	et	NNP
cord-291727-4wfhuvww	66	30	al	al	NNP
cord-291727-4wfhuvww	66	31	.	.	NNP
cord-291727-4wfhuvww	66	32	,	,	,
cord-291727-4wfhuvww	66	33	2000a	2000a	CD
cord-291727-4wfhuvww	66	34	)	)	-RRB-
cord-291727-4wfhuvww	66	35	.	.	.
cord-291727-4wfhuvww	67	1	How	how	WRB
cord-291727-4wfhuvww	67	2	polyamines	polyamine	NNS
cord-291727-4wfhuvww	67	3	regulate	regulate	VBP
cord-291727-4wfhuvww	67	4	+1	+1	HYPH
cord-291727-4wfhuvww	67	5	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	67	6	is	be	VBZ
cord-291727-4wfhuvww	67	7	not	not	RB
cord-291727-4wfhuvww	67	8	well	well	RB
cord-291727-4wfhuvww	67	9	understood	understand	VBN
cord-291727-4wfhuvww	67	10	,	,	,
cord-291727-4wfhuvww	67	11	but	but	CC
cord-291727-4wfhuvww	67	12	one	one	CD
cord-291727-4wfhuvww	67	13	hypothesis	hypothesis	NN
cord-291727-4wfhuvww	67	14	is	be	VBZ
cord-291727-4wfhuvww	67	15	that	that	IN
cord-291727-4wfhuvww	67	16	polyamine	polyamine	NN
cord-291727-4wfhuvww	67	17	binding	bind	VBG
cord-291727-4wfhuvww	67	18	to	to	IN
cord-291727-4wfhuvww	67	19	RNA	RNA	NNP
cord-291727-4wfhuvww	67	20	may	may	MD
cord-291727-4wfhuvww	67	21	enable	enable	VB
cord-291727-4wfhuvww	67	22	read	read	VB
cord-291727-4wfhuvww	67	23	-	-	HYPH
cord-291727-4wfhuvww	67	24	through	through	NN
cord-291727-4wfhuvww	67	25	of	of	IN
cord-291727-4wfhuvww	67	26	the	the	DT
cord-291727-4wfhuvww	67	27	termination	termination	NN
cord-291727-4wfhuvww	67	28	codon	codon	NN
cord-291727-4wfhuvww	67	29	.	.	.
cord-291727-4wfhuvww	68	1	Similar	similar	JJ
cord-291727-4wfhuvww	68	2	to	to	IN
cord-291727-4wfhuvww	68	3	polyamines	polyamine	NNS
cord-291727-4wfhuvww	68	4	,	,	,
cord-291727-4wfhuvww	68	5	amino	amino	NNS
cord-291727-4wfhuvww	68	6	-	-	HYPH
cord-291727-4wfhuvww	68	7	glycosides	glycoside	NNS
cord-291727-4wfhuvww	68	8	such	such	JJ
cord-291727-4wfhuvww	68	9	as	as	IN
cord-291727-4wfhuvww	68	10	gentamicin	gentamicin	NNS
cord-291727-4wfhuvww	68	11	allow	allow	VBP
cord-291727-4wfhuvww	68	12	read	read	VBN
cord-291727-4wfhuvww	68	13	-	-	HYPH
cord-291727-4wfhuvww	68	14	through	through	NN
cord-291727-4wfhuvww	68	15	of	of	IN
cord-291727-4wfhuvww	68	16	stop	stop	NN
cord-291727-4wfhuvww	68	17	-	-	HYPH
cord-291727-4wfhuvww	68	18	codons	codon	NNS
cord-291727-4wfhuvww	69	1	(	(	-LRB-
cord-291727-4wfhuvww	69	2	Martin	Martin	NNP
cord-291727-4wfhuvww	69	3	et	et	NNP
cord-291727-4wfhuvww	69	4	al	al	NNP
cord-291727-4wfhuvww	69	5	.	.	.
cord-291727-4wfhuvww	70	1	,	,	,
cord-291727-4wfhuvww	70	2	1989	1989	CD
cord-291727-4wfhuvww	70	3	;	;	:
cord-291727-4wfhuvww	70	4	Malik	Malik	NNP
cord-291727-4wfhuvww	70	5	et	et	NNP
cord-291727-4wfhuvww	70	6	al	al	NNP
cord-291727-4wfhuvww	70	7	.	.	NNP
cord-291727-4wfhuvww	70	8	,	,	,
cord-291727-4wfhuvww	70	9	2010	2010	CD
cord-291727-4wfhuvww	70	10	)	)	-RRB-
cord-291727-4wfhuvww	70	11	.	.	.
cord-291727-4wfhuvww	71	1	It	-PRON-	PRP
cord-291727-4wfhuvww	71	2	is	be	VBZ
cord-291727-4wfhuvww	71	3	not	not	RB
cord-291727-4wfhuvww	71	4	clear	clear	JJ
cord-291727-4wfhuvww	71	5	at	at	IN
cord-291727-4wfhuvww	71	6	present	present	JJ
cord-291727-4wfhuvww	71	7	whether	whether	IN
cord-291727-4wfhuvww	71	8	there	there	EX
cord-291727-4wfhuvww	71	9	are	be	VBP
cord-291727-4wfhuvww	71	10	normal	normal	JJ
cord-291727-4wfhuvww	71	11	regulator	regulator	NN
cord-291727-4wfhuvww	71	12	proteins	protein	NNS
cord-291727-4wfhuvww	71	13	that	that	WDT
cord-291727-4wfhuvww	71	14	enhance	enhance	VBP
cord-291727-4wfhuvww	71	15	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	71	16	efficiencies	efficiency	NNS
cord-291727-4wfhuvww	71	17	.	.	.
cord-291727-4wfhuvww	72	1	Because	because	IN
cord-291727-4wfhuvww	72	2	−1	−1	NNP
cord-291727-4wfhuvww	72	3	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	72	4	is	be	VBZ
cord-291727-4wfhuvww	72	5	essential	essential	JJ
cord-291727-4wfhuvww	72	6	for	for	IN
cord-291727-4wfhuvww	72	7	retroviral	retroviral	JJ
cord-291727-4wfhuvww	72	8	gene	gene	NN
cord-291727-4wfhuvww	72	9	expression	expression	NN
cord-291727-4wfhuvww	72	10	,	,	,
cord-291727-4wfhuvww	72	11	it	-PRON-	PRP
cord-291727-4wfhuvww	72	12	has	have	VBZ
cord-291727-4wfhuvww	72	13	been	be	VBN
cord-291727-4wfhuvww	72	14	proposed	propose	VBN
cord-291727-4wfhuvww	72	15	that	that	IN
cord-291727-4wfhuvww	72	16	chemical	chemical	JJ
cord-291727-4wfhuvww	72	17	interference	interference	NN
cord-291727-4wfhuvww	72	18	with	with	IN
cord-291727-4wfhuvww	72	19	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	72	20	would	would	MD
cord-291727-4wfhuvww	72	21	be	be	VB
cord-291727-4wfhuvww	72	22	a	a	DT
cord-291727-4wfhuvww	72	23	good	good	JJ
cord-291727-4wfhuvww	72	24	anti	anti	JJ
cord-291727-4wfhuvww	72	25	-	-	JJ
cord-291727-4wfhuvww	72	26	viral	viral	JJ
cord-291727-4wfhuvww	72	27	strategy	strategy	NN
cord-291727-4wfhuvww	72	28	.	.	.
cord-291727-4wfhuvww	73	1	Recently	recently	RB
cord-291727-4wfhuvww	73	2	,	,	,
cord-291727-4wfhuvww	73	3	a	a	DT
cord-291727-4wfhuvww	73	4	genome	genome	NN
cord-291727-4wfhuvww	73	5	-	-	HYPH
cord-291727-4wfhuvww	73	6	wide	wide	JJ
cord-291727-4wfhuvww	73	7	screen	screen	NN
cord-291727-4wfhuvww	73	8	to	to	TO
cord-291727-4wfhuvww	73	9	identify	identify	VB
cord-291727-4wfhuvww	73	10	regulators	regulator	NNS
cord-291727-4wfhuvww	73	11	of	of	IN
cord-291727-4wfhuvww	73	12	HIV-1	HIV-1	NNP
cord-291727-4wfhuvww	73	13	frameshifting	frameshifting	NNP
cord-291727-4wfhuvww	73	14	has	have	VBZ
cord-291727-4wfhuvww	73	15	identified	identify	VBN
cord-291727-4wfhuvww	73	16	eRF1	erf1	RB
cord-291727-4wfhuvww	73	17	as	as	IN
cord-291727-4wfhuvww	73	18	an	an	DT
cord-291727-4wfhuvww	73	19	essential	essential	JJ
cord-291727-4wfhuvww	73	20	host	host	NN
cord-291727-4wfhuvww	73	21	gene	gene	NN
cord-291727-4wfhuvww	73	22	required	require	VBN
cord-291727-4wfhuvww	73	23	for	for	IN
cord-291727-4wfhuvww	73	24	−1	−1	NNP
cord-291727-4wfhuvww	73	25	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	73	26	(	(	-LRB-
cord-291727-4wfhuvww	73	27	Kobayashi	Kobayashi	NNP
cord-291727-4wfhuvww	73	28	et	et	FW
cord-291727-4wfhuvww	73	29	al	al	NNP
cord-291727-4wfhuvww	73	30	.	.	NNP
cord-291727-4wfhuvww	73	31	,	,	,
cord-291727-4wfhuvww	73	32	2010	2010	CD
cord-291727-4wfhuvww	73	33	)	)	-RRB-
cord-291727-4wfhuvww	73	34	,	,	,
cord-291727-4wfhuvww	73	35	suggesting	suggest	VBG
cord-291727-4wfhuvww	73	36	that	that	IN
cord-291727-4wfhuvww	73	37	eRF1	eRF1	NNP
cord-291727-4wfhuvww	73	38	may	may	MD
cord-291727-4wfhuvww	73	39	be	be	VB
cord-291727-4wfhuvww	73	40	a	a	DT
cord-291727-4wfhuvww	73	41	good	good	JJ
cord-291727-4wfhuvww	73	42	therapeutic	therapeutic	JJ
cord-291727-4wfhuvww	73	43	target	target	NN
cord-291727-4wfhuvww	73	44	in	in	IN
cord-291727-4wfhuvww	73	45	AIDS	AIDS	NNP
cord-291727-4wfhuvww	74	1	(	(	-LRB-
cord-291727-4wfhuvww	74	2	Brakier	Brakier	NNP
cord-291727-4wfhuvww	74	3	-	-	HYPH
cord-291727-4wfhuvww	74	4	Gingras	Gingras	NNP
cord-291727-4wfhuvww	74	5	et	et	NNP
cord-291727-4wfhuvww	74	6	al	al	NNP
cord-291727-4wfhuvww	74	7	.	.	NNP
cord-291727-4wfhuvww	74	8	,	,	,
cord-291727-4wfhuvww	74	9	2012	2012	CD
cord-291727-4wfhuvww	74	10	)	)	-RRB-
cord-291727-4wfhuvww	74	11	.	.	.
cord-291727-4wfhuvww	75	1	In	in	IN
cord-291727-4wfhuvww	75	2	addition	addition	NN
cord-291727-4wfhuvww	75	3	,	,	,
cord-291727-4wfhuvww	75	4	it	-PRON-	PRP
cord-291727-4wfhuvww	75	5	has	have	VBZ
cord-291727-4wfhuvww	75	6	been	be	VBN
cord-291727-4wfhuvww	75	7	proposed	propose	VBN
cord-291727-4wfhuvww	75	8	that	that	IN
cord-291727-4wfhuvww	75	9	HIV	HIV	NNP
cord-291727-4wfhuvww	75	10	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	75	11	can	can	MD
cord-291727-4wfhuvww	75	12	be	be	VB
cord-291727-4wfhuvww	75	13	modulated	modulate	VBN
cord-291727-4wfhuvww	75	14	by	by	IN
cord-291727-4wfhuvww	75	15	protein	protein	NN
cord-291727-4wfhuvww	75	16	kinase	kinase	NN
cord-291727-4wfhuvww	75	17	R	r	NN
cord-291727-4wfhuvww	75	18	,	,	,
cord-291727-4wfhuvww	75	19	as	as	RB
cord-291727-4wfhuvww	75	20	well	well	RB
cord-291727-4wfhuvww	75	21	as	as	IN
cord-291727-4wfhuvww	75	22	by	by	IN
cord-291727-4wfhuvww	75	23	factors	factor	NNS
cord-291727-4wfhuvww	75	24	that	that	WDT
cord-291727-4wfhuvww	75	25	modulate	modulate	VBP
cord-291727-4wfhuvww	75	26	translation	translation	NN
cord-291727-4wfhuvww	75	27	efficiency	efficiency	NN
cord-291727-4wfhuvww	75	28	such	such	JJ
cord-291727-4wfhuvww	75	29	as	as	IN
cord-291727-4wfhuvww	75	30	rapamycin	rapamycin	NNP
cord-291727-4wfhuvww	75	31	(	(	-LRB-
cord-291727-4wfhuvww	75	32	Gendron	Gendron	NNP
cord-291727-4wfhuvww	75	33	et	et	NNP
cord-291727-4wfhuvww	75	34	al	al	NNP
cord-291727-4wfhuvww	75	35	.	.	NNP
cord-291727-4wfhuvww	75	36	,	,	,
cord-291727-4wfhuvww	75	37	2008	2008	CD
cord-291727-4wfhuvww	75	38	)	)	-RRB-
cord-291727-4wfhuvww	75	39	.	.	.
cord-291727-4wfhuvww	76	1	Interestingly	interestingly	RB
cord-291727-4wfhuvww	76	2	,	,	,
cord-291727-4wfhuvww	76	3	annexin	annexin	NNP
cord-291727-4wfhuvww	76	4	A2	A2	NNP
cord-291727-4wfhuvww	76	5	(	(	-LRB-
cord-291727-4wfhuvww	76	6	ANXA2	ANXA2	NNP
cord-291727-4wfhuvww	76	7	)	)	-RRB-
cord-291727-4wfhuvww	76	8	can	can	MD
cord-291727-4wfhuvww	76	9	bind	bind	VB
cord-291727-4wfhuvww	76	10	the	the	DT
cord-291727-4wfhuvww	76	11	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	76	12	structure	structure	NN
cord-291727-4wfhuvww	76	13	of	of	IN
cord-291727-4wfhuvww	76	14	avian	avian	JJ
cord-291727-4wfhuvww	76	15	coronavirus	coronavirus	NN
cord-291727-4wfhuvww	76	16	infectious	infectious	JJ
cord-291727-4wfhuvww	76	17	bronchitis	bronchitis	NN
cord-291727-4wfhuvww	76	18	virus	virus	NN
cord-291727-4wfhuvww	76	19	(	(	-LRB-
cord-291727-4wfhuvww	76	20	IBV	IBV	NNP
cord-291727-4wfhuvww	76	21	)	)	-RRB-
cord-291727-4wfhuvww	76	22	and	and	CC
cord-291727-4wfhuvww	76	23	reduce	reduce	VB
cord-291727-4wfhuvww	76	24	−1	−1	NNP
cord-291727-4wfhuvww	76	25	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	76	26	(	(	-LRB-
cord-291727-4wfhuvww	76	27	Kwak	Kwak	NNP
cord-291727-4wfhuvww	76	28	et	et	NNP
cord-291727-4wfhuvww	76	29	al	al	NNP
cord-291727-4wfhuvww	76	30	.	.	NNP
cord-291727-4wfhuvww	76	31	,	,	,
cord-291727-4wfhuvww	76	32	2011	2011	CD
cord-291727-4wfhuvww	76	33	)	)	-RRB-
cord-291727-4wfhuvww	76	34	.	.	.
cord-291727-4wfhuvww	77	1	As	as	IN
cord-291727-4wfhuvww	77	2	a	a	DT
cord-291727-4wfhuvww	77	3	consequence	consequence	NN
cord-291727-4wfhuvww	77	4	,	,	,
cord-291727-4wfhuvww	77	5	ANXA2	ANXA2	NNP
cord-291727-4wfhuvww	77	6	has	have	VBZ
cord-291727-4wfhuvww	77	7	been	be	VBN
cord-291727-4wfhuvww	77	8	suggested	suggest	VBN
cord-291727-4wfhuvww	77	9	as	as	IN
cord-291727-4wfhuvww	77	10	a	a	DT
cord-291727-4wfhuvww	77	11	more	more	RBR
cord-291727-4wfhuvww	77	12	general	general	JJ
cord-291727-4wfhuvww	77	13	antiviral	antiviral	JJ
cord-291727-4wfhuvww	77	14	regulator	regulator	NN
cord-291727-4wfhuvww	77	15	in	in	IN
cord-291727-4wfhuvww	77	16	eukaryotic	eukaryotic	JJ
cord-291727-4wfhuvww	77	17	cells	cell	NNS
cord-291727-4wfhuvww	77	18	.	.	.
cord-291727-4wfhuvww	78	1	Other	other	JJ
cord-291727-4wfhuvww	78	2	potential	potential	JJ
cord-291727-4wfhuvww	78	3	anti	anti	JJ
cord-291727-4wfhuvww	78	4	-	-	JJ
cord-291727-4wfhuvww	78	5	viral	viral	JJ
cord-291727-4wfhuvww	78	6	agents	agent	NNS
cord-291727-4wfhuvww	78	7	could	could	MD
cord-291727-4wfhuvww	78	8	either	either	CC
cord-291727-4wfhuvww	78	9	specifically	specifically	RB
cord-291727-4wfhuvww	78	10	bind	bind	VB
cord-291727-4wfhuvww	78	11	to	to	IN
cord-291727-4wfhuvww	78	12	the	the	DT
cord-291727-4wfhuvww	78	13	frameshift	frameshift	NN
cord-291727-4wfhuvww	78	14	signal	signal	NN
cord-291727-4wfhuvww	78	15	(	(	-LRB-
cord-291727-4wfhuvww	78	16	such	such	JJ
cord-291727-4wfhuvww	78	17	as	as	IN
cord-291727-4wfhuvww	78	18	antisense	antisense	NN
cord-291727-4wfhuvww	78	19	oligonucleotides	oligonucleotide	NNS
cord-291727-4wfhuvww	78	20	,	,	,
cord-291727-4wfhuvww	78	21	non	non	JJ
cord-291727-4wfhuvww	78	22	-	-	JJ
cord-291727-4wfhuvww	78	23	coding	coding	JJ
cord-291727-4wfhuvww	78	24	RNAs	rna	NNS
cord-291727-4wfhuvww	78	25	,	,	,
cord-291727-4wfhuvww	78	26	or	or	CC
cord-291727-4wfhuvww	78	27	frameshift	frameshift	NN
cord-291727-4wfhuvww	78	28	signal	signal	NN
cord-291727-4wfhuvww	78	29	binding	binding	NN
cord-291727-4wfhuvww	78	30	compounds	compound	NNS
cord-291727-4wfhuvww	78	31	)	)	-RRB-
cord-291727-4wfhuvww	78	32	or	or	CC
cord-291727-4wfhuvww	78	33	interfere	interfere	VB
cord-291727-4wfhuvww	78	34	with	with	IN
cord-291727-4wfhuvww	78	35	peptidyltransferase	peptidyltransferase	NN
cord-291727-4wfhuvww	78	36	activity	activity	NN
cord-291727-4wfhuvww	78	37	(	(	-LRB-
cord-291727-4wfhuvww	78	38	e.g.	e.g.	RB
cord-291727-4wfhuvww	78	39	,	,	,
cord-291727-4wfhuvww	78	40	anisomycin	anisomycin	NNP
cord-291727-4wfhuvww	78	41	or	or	CC
cord-291727-4wfhuvww	78	42	sparsomycin	sparsomycin	NNP
cord-291727-4wfhuvww	78	43	)	)	-RRB-
cord-291727-4wfhuvww	78	44	or	or	CC
cord-291727-4wfhuvww	78	45	eEF2	eEF2	NNP
cord-291727-4wfhuvww	78	46	activity	activity	NN
cord-291727-4wfhuvww	78	47	(	(	-LRB-
cord-291727-4wfhuvww	78	48	e.g.	e.g.	RB
cord-291727-4wfhuvww	78	49	,	,	,
cord-291727-4wfhuvww	78	50	sordarin	sordarin	NNP
cord-291727-4wfhuvww	78	51	)	)	-RRB-
cord-291727-4wfhuvww	78	52	(	(	-LRB-
cord-291727-4wfhuvww	78	53	Dinman	Dinman	NNP
cord-291727-4wfhuvww	78	54	,	,	,
cord-291727-4wfhuvww	78	55	2012b	2012b	CD
cord-291727-4wfhuvww	78	56	)	)	-RRB-
cord-291727-4wfhuvww	78	57	.	.	.
cord-291727-4wfhuvww	79	1	For	for	IN
cord-291727-4wfhuvww	79	2	certain	certain	JJ
cord-291727-4wfhuvww	79	3	diseases	disease	NNS
cord-291727-4wfhuvww	79	4	,	,	,
cord-291727-4wfhuvww	79	5	however	however	RB
cord-291727-4wfhuvww	79	6	,	,	,
cord-291727-4wfhuvww	79	7	it	-PRON-	PRP
cord-291727-4wfhuvww	79	8	may	may	MD
cord-291727-4wfhuvww	79	9	be	be	VB
cord-291727-4wfhuvww	79	10	benefitial	benefitial	JJ
cord-291727-4wfhuvww	79	11	to	to	TO
cord-291727-4wfhuvww	79	12	enhance	enhance	VB
cord-291727-4wfhuvww	79	13	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	79	14	.	.	.
cord-291727-4wfhuvww	80	1	For	for	IN
cord-291727-4wfhuvww	80	2	instance	instance	NN
cord-291727-4wfhuvww	80	3	,	,	,
cord-291727-4wfhuvww	80	4	in	in	IN
cord-291727-4wfhuvww	80	5	monogenetic	monogenetic	JJ
cord-291727-4wfhuvww	80	6	diseases	disease	NNS
cord-291727-4wfhuvww	80	7	such	such	JJ
cord-291727-4wfhuvww	80	8	as	as	IN
cord-291727-4wfhuvww	80	9	cystic	cystic	JJ
cord-291727-4wfhuvww	80	10	fibrosis	fibrosis	NN
cord-291727-4wfhuvww	80	11	or	or	CC
cord-291727-4wfhuvww	80	12	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	80	13	's	's	POS
cord-291727-4wfhuvww	80	14	muscular	muscular	JJ
cord-291727-4wfhuvww	80	15	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	80	16	,	,	,
cord-291727-4wfhuvww	80	17	where	where	WRB
cord-291727-4wfhuvww	80	18	frameshift	frameshift	NN
cord-291727-4wfhuvww	80	19	mutations	mutation	NNS
cord-291727-4wfhuvww	80	20	result	result	VBP
cord-291727-4wfhuvww	80	21	in	in	IN
cord-291727-4wfhuvww	80	22	premature	premature	JJ
cord-291727-4wfhuvww	80	23	translation	translation	NN
cord-291727-4wfhuvww	80	24	termination	termination	NN
cord-291727-4wfhuvww	80	25	,	,	,
cord-291727-4wfhuvww	80	26	the	the	DT
cord-291727-4wfhuvww	80	27	deliberate	deliberate	JJ
cord-291727-4wfhuvww	80	28	induction	induction	NN
cord-291727-4wfhuvww	80	29	of	of	IN
cord-291727-4wfhuvww	80	30	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	80	31	may	may	MD
cord-291727-4wfhuvww	80	32	overcome	overcome	VB
cord-291727-4wfhuvww	80	33	the	the	DT
cord-291727-4wfhuvww	80	34	problem	problem	NN
cord-291727-4wfhuvww	80	35	by	by	IN
cord-291727-4wfhuvww	80	36	skipping	skip	VBG
cord-291727-4wfhuvww	80	37	the	the	DT
cord-291727-4wfhuvww	80	38	affected	affect	VBN
cord-291727-4wfhuvww	80	39	sites	site	NNS
cord-291727-4wfhuvww	80	40	(	(	-LRB-
cord-291727-4wfhuvww	80	41	Aurino	Aurino	NNP
cord-291727-4wfhuvww	80	42	and	and	CC
cord-291727-4wfhuvww	80	43	Nigro	Nigro	NNP
cord-291727-4wfhuvww	80	44	,	,	,
cord-291727-4wfhuvww	80	45	2006	2006	CD
cord-291727-4wfhuvww	80	46	)	)	-RRB-
cord-291727-4wfhuvww	80	47	.	.	.
cord-291727-4wfhuvww	81	1	It	-PRON-	PRP
cord-291727-4wfhuvww	81	2	has	have	VBZ
cord-291727-4wfhuvww	81	3	been	be	VBN
cord-291727-4wfhuvww	81	4	noted	note	VBN
cord-291727-4wfhuvww	81	5	that	that	IN
cord-291727-4wfhuvww	81	6	aminoglycosides	aminoglycoside	NNS
cord-291727-4wfhuvww	81	7	such	such	JJ
cord-291727-4wfhuvww	81	8	as	as	IN
cord-291727-4wfhuvww	81	9	gentamicin	gentamicin	NNP
cord-291727-4wfhuvww	81	10	can	can	MD
cord-291727-4wfhuvww	81	11	enhance	enhance	VB
cord-291727-4wfhuvww	81	12	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	81	13	and	and	CC
cord-291727-4wfhuvww	81	14	stop	stop	VB
cord-291727-4wfhuvww	81	15	codon	codon	NN
cord-291727-4wfhuvww	81	16	read	read	VB
cord-291727-4wfhuvww	81	17	-	-	HYPH
cord-291727-4wfhuvww	81	18	through	through	NN
cord-291727-4wfhuvww	81	19	.	.	.
cord-291727-4wfhuvww	82	1	Gentamicin	gentamicin	NN
cord-291727-4wfhuvww	82	2	-	-	HYPH
cord-291727-4wfhuvww	82	3	induced	induce	VBN
cord-291727-4wfhuvww	82	4	read	read	NN
cord-291727-4wfhuvww	82	5	-	-	HYPH
cord-291727-4wfhuvww	82	6	through	through	NN
cord-291727-4wfhuvww	82	7	of	of	IN
cord-291727-4wfhuvww	82	8	stop	stop	NN
cord-291727-4wfhuvww	82	9	codons	codon	NNS
cord-291727-4wfhuvww	82	10	has	have	VBZ
cord-291727-4wfhuvww	82	11	been	be	VBN
cord-291727-4wfhuvww	82	12	evaluated	evaluate	VBN
cord-291727-4wfhuvww	82	13	as	as	IN
cord-291727-4wfhuvww	82	14	a	a	DT
cord-291727-4wfhuvww	82	15	treatment	treatment	NN
cord-291727-4wfhuvww	82	16	option	option	NN
cord-291727-4wfhuvww	82	17	for	for	IN
cord-291727-4wfhuvww	82	18	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	82	19	's	's	POS
cord-291727-4wfhuvww	82	20	muscular	muscular	JJ
cord-291727-4wfhuvww	82	21	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	82	22	(	(	-LRB-
cord-291727-4wfhuvww	82	23	Malik	Malik	NNP
cord-291727-4wfhuvww	82	24	et	et	NNP
cord-291727-4wfhuvww	82	25	al	al	NNP
cord-291727-4wfhuvww	82	26	.	.	NNP
cord-291727-4wfhuvww	82	27	,	,	,
cord-291727-4wfhuvww	82	28	2010	2010	CD
cord-291727-4wfhuvww	82	29	)	)	-RRB-
cord-291727-4wfhuvww	82	30	.	.	.
cord-291727-4wfhuvww	83	1	While	while	IN
cord-291727-4wfhuvww	83	2	the	the	DT
cord-291727-4wfhuvww	83	3	authors	author	NNS
cord-291727-4wfhuvww	83	4	conclude	conclude	VBP
cord-291727-4wfhuvww	83	5	from	from	IN
cord-291727-4wfhuvww	83	6	this	this	DT
cord-291727-4wfhuvww	83	7	phase	phase	NN
cord-291727-4wfhuvww	83	8	I	-PRON-	PRP
cord-291727-4wfhuvww	83	9	clinical	clinical	JJ
cord-291727-4wfhuvww	83	10	trial	trial	NN
cord-291727-4wfhuvww	83	11	that	that	IN
cord-291727-4wfhuvww	83	12	gentamicin	gentamicin	NNP
cord-291727-4wfhuvww	83	13	may	may	MD
cord-291727-4wfhuvww	83	14	not	not	RB
cord-291727-4wfhuvww	83	15	be	be	VB
cord-291727-4wfhuvww	83	16	a	a	DT
cord-291727-4wfhuvww	83	17	good	good	JJ
cord-291727-4wfhuvww	83	18	treatment	treatment	NN
cord-291727-4wfhuvww	83	19	option	option	NN
cord-291727-4wfhuvww	83	20	,	,	,
cord-291727-4wfhuvww	83	21	they	-PRON-	PRP
cord-291727-4wfhuvww	83	22	note	note	VBP
cord-291727-4wfhuvww	83	23	that	that	IN
cord-291727-4wfhuvww	83	24	other	other	JJ
cord-291727-4wfhuvww	83	25	read	read	VB
cord-291727-4wfhuvww	83	26	-	-	HYPH
cord-291727-4wfhuvww	83	27	through	through	RP
cord-291727-4wfhuvww	83	28	agents	agent	NNS
cord-291727-4wfhuvww	83	29	may	may	MD
cord-291727-4wfhuvww	83	30	have	have	VB
cord-291727-4wfhuvww	83	31	benefits	benefit	NNS
cord-291727-4wfhuvww	83	32	.	.	.
cord-291727-4wfhuvww	84	1	A	a	DT
cord-291727-4wfhuvww	84	2	phase	phase	NN
cord-291727-4wfhuvww	84	3	I	-PRON-	PRP
cord-291727-4wfhuvww	84	4	/	/	SYM
cord-291727-4wfhuvww	84	5	II	II	NNP
cord-291727-4wfhuvww	84	6	clinical	clinical	JJ
cord-291727-4wfhuvww	84	7	trial	trial	NN
cord-291727-4wfhuvww	84	8	using	use	VBG
cord-291727-4wfhuvww	84	9	a	a	DT
cord-291727-4wfhuvww	84	10	morpholino	morpholino	NNP
cord-291727-4wfhuvww	84	11	oligomer	oligomer	NNP
cord-291727-4wfhuvww	84	12	(	(	-LRB-
cord-291727-4wfhuvww	84	13	AVI-4658	AVI-4658	NNP
cord-291727-4wfhuvww	84	14	)	)	-RRB-
cord-291727-4wfhuvww	84	15	to	to	TO
cord-291727-4wfhuvww	84	16	correct	correct	VB
cord-291727-4wfhuvww	84	17	a	a	DT
cord-291727-4wfhuvww	84	18	frameshift	frameshift	NN
cord-291727-4wfhuvww	84	19	mutation	mutation	NN
cord-291727-4wfhuvww	84	20	in	in	IN
cord-291727-4wfhuvww	84	21	the	the	DT
cord-291727-4wfhuvww	84	22	dystrophin	dystrophin	NN
cord-291727-4wfhuvww	84	23	gene	gene	NN
cord-291727-4wfhuvww	84	24	has	have	VBZ
cord-291727-4wfhuvww	84	25	been	be	VBN
cord-291727-4wfhuvww	84	26	completed	complete	VBN
cord-291727-4wfhuvww	84	27	with	with	IN
cord-291727-4wfhuvww	84	28	the	the	DT
cord-291727-4wfhuvww	84	29	conclusion	conclusion	NN
cord-291727-4wfhuvww	84	30	that	that	IN
cord-291727-4wfhuvww	84	31	AVI-4658	AVI-4658	NNP
cord-291727-4wfhuvww	84	32	was	be	VBD
cord-291727-4wfhuvww	84	33	well	well	RB
cord-291727-4wfhuvww	84	34	tolerated	tolerate	VBN
cord-291727-4wfhuvww	84	35	and	and	CC
cord-291727-4wfhuvww	84	36	had	have	VBD
cord-291727-4wfhuvww	84	37	significant	significant	JJ
cord-291727-4wfhuvww	84	38	benefit	benefit	NN
cord-291727-4wfhuvww	84	39	in	in	IN
cord-291727-4wfhuvww	84	40	patients	patient	NNS
cord-291727-4wfhuvww	84	41	with	with	IN
cord-291727-4wfhuvww	84	42	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	84	43	's	's	POS
cord-291727-4wfhuvww	84	44	muscular	muscular	JJ
cord-291727-4wfhuvww	84	45	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	84	46	(	(	-LRB-
cord-291727-4wfhuvww	84	47	Cirak	Cirak	NNP
cord-291727-4wfhuvww	84	48	et	et	NNP
cord-291727-4wfhuvww	84	49	al	al	NNP
cord-291727-4wfhuvww	84	50	.	.	NNP
cord-291727-4wfhuvww	84	51	,	,	,
cord-291727-4wfhuvww	84	52	2011	2011	CD
cord-291727-4wfhuvww	84	53	)	)	-RRB-
cord-291727-4wfhuvww	84	54	.	.	.
cord-291727-4wfhuvww	85	1	Genome	genome	NN
cord-291727-4wfhuvww	85	2	-	-	HYPH
cord-291727-4wfhuvww	85	3	wide	wide	JJ
cord-291727-4wfhuvww	85	4	analysis	analysis	NN
cord-291727-4wfhuvww	85	5	of	of	IN
cord-291727-4wfhuvww	85	6	the	the	DT
cord-291727-4wfhuvww	85	7	yeast	yeast	NN
cord-291727-4wfhuvww	85	8	genome	genome	NN
cord-291727-4wfhuvww	86	1	(	(	-LRB-
cord-291727-4wfhuvww	86	2	Jacobs	Jacobs	NNP
cord-291727-4wfhuvww	86	3	et	et	NNP
cord-291727-4wfhuvww	86	4	al	al	NNP
cord-291727-4wfhuvww	86	5	.	.	NNP
cord-291727-4wfhuvww	86	6	,	,	,
cord-291727-4wfhuvww	86	7	2007	2007	CD
cord-291727-4wfhuvww	86	8	)	)	-RRB-
cord-291727-4wfhuvww	86	9	and	and	CC
cord-291727-4wfhuvww	86	10	other	other	JJ
cord-291727-4wfhuvww	86	11	genomes	genome	NNS
cord-291727-4wfhuvww	86	12	(	(	-LRB-
cord-291727-4wfhuvww	86	13	Hammell	Hammell	NNP
cord-291727-4wfhuvww	86	14	et	et	FW
cord-291727-4wfhuvww	86	15	al	al	NNP
cord-291727-4wfhuvww	86	16	.	.	NNP
cord-291727-4wfhuvww	86	17	,	,	,
cord-291727-4wfhuvww	86	18	1999	1999	CD
cord-291727-4wfhuvww	86	19	)	)	-RRB-
cord-291727-4wfhuvww	86	20	suggests	suggest	VBZ
cord-291727-4wfhuvww	86	21	that	that	IN
cord-291727-4wfhuvww	86	22	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	86	23	is	be	VBZ
cord-291727-4wfhuvww	86	24	more	more	RBR
cord-291727-4wfhuvww	86	25	common	common	JJ
cord-291727-4wfhuvww	86	26	than	than	IN
cord-291727-4wfhuvww	86	27	previously	previously	RB
cord-291727-4wfhuvww	86	28	thought	think	VBN
cord-291727-4wfhuvww	86	29	.	.	.
cord-291727-4wfhuvww	87	1	However	however	RB
cord-291727-4wfhuvww	87	2	,	,	,
cord-291727-4wfhuvww	87	3	it	-PRON-	PRP
cord-291727-4wfhuvww	87	4	has	have	VBZ
cord-291727-4wfhuvww	87	5	been	be	VBN
cord-291727-4wfhuvww	87	6	proposed	propose	VBN
cord-291727-4wfhuvww	87	7	that	that	IN
cord-291727-4wfhuvww	87	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	87	9	may	may	MD
cord-291727-4wfhuvww	87	10	predominantly	predominantly	RB
cord-291727-4wfhuvww	87	11	serve	serve	VB
cord-291727-4wfhuvww	87	12	to	to	TO
cord-291727-4wfhuvww	87	13	modulate	modulate	VB
cord-291727-4wfhuvww	87	14	RNA	RNA	NNP
cord-291727-4wfhuvww	87	15	levels	level	NNS
cord-291727-4wfhuvww	87	16	rather	rather	RB
cord-291727-4wfhuvww	87	17	than	than	IN
cord-291727-4wfhuvww	87	18	to	to	TO
cord-291727-4wfhuvww	87	19	produce	produce	VB
cord-291727-4wfhuvww	87	20	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	87	21	proteins	protein	NNS
cord-291727-4wfhuvww	87	22	(	(	-LRB-
cord-291727-4wfhuvww	87	23	Plant	Plant	NNP
cord-291727-4wfhuvww	87	24	et	et	NNP
cord-291727-4wfhuvww	87	25	al	al	NNP
cord-291727-4wfhuvww	87	26	.	.	NNP
cord-291727-4wfhuvww	87	27	,	,	,
cord-291727-4wfhuvww	87	28	2004	2004	CD
cord-291727-4wfhuvww	87	29	)	)	-RRB-
cord-291727-4wfhuvww	87	30	.	.	.
cord-291727-4wfhuvww	88	1	Evolutionary	evolutionary	JJ
cord-291727-4wfhuvww	88	2	studies	study	NNS
cord-291727-4wfhuvww	88	3	argue	argue	VBP
cord-291727-4wfhuvww	88	4	that	that	IN
cord-291727-4wfhuvww	88	5	the	the	DT
cord-291727-4wfhuvww	88	6	generation	generation	NN
cord-291727-4wfhuvww	88	7	of	of	IN
cord-291727-4wfhuvww	88	8	out	out	IN
cord-291727-4wfhuvww	88	9	-	-	HYPH
cord-291727-4wfhuvww	88	10	of	of	IN
cord-291727-4wfhuvww	88	11	-	-	HYPH
cord-291727-4wfhuvww	88	12	frame	frame	NN
cord-291727-4wfhuvww	88	13	proteins	protein	NNS
cord-291727-4wfhuvww	88	14	has	have	VBZ
cord-291727-4wfhuvww	88	15	been	be	VBN
cord-291727-4wfhuvww	88	16	minimized	minimize	VBN
cord-291727-4wfhuvww	88	17	by	by	IN
cord-291727-4wfhuvww	88	18	codon	codon	NN
cord-291727-4wfhuvww	88	19	optimization	optimization	NN
cord-291727-4wfhuvww	88	20	that	that	WDT
cord-291727-4wfhuvww	88	21	results	result	VBZ
cord-291727-4wfhuvww	88	22	in	in	IN
cord-291727-4wfhuvww	88	23	non	non	JJ
cord-291727-4wfhuvww	88	24	-	-	JJ
cord-291727-4wfhuvww	88	25	functional	functional	JJ
cord-291727-4wfhuvww	88	26	small	small	JJ
cord-291727-4wfhuvww	88	27	peptides	peptide	NNS
cord-291727-4wfhuvww	88	28	rather	rather	RB
cord-291727-4wfhuvww	88	29	than	than	IN
cord-291727-4wfhuvww	88	30	functional	functional	JJ
cord-291727-4wfhuvww	88	31	proteins	protein	NNS
cord-291727-4wfhuvww	89	1	(	(	-LRB-
cord-291727-4wfhuvww	89	2	Bollenbach	Bollenbach	NNP
cord-291727-4wfhuvww	89	3	et	et	NNP
cord-291727-4wfhuvww	89	4	al	al	NNP
cord-291727-4wfhuvww	89	5	.	.	NNP
cord-291727-4wfhuvww	89	6	,	,	,
cord-291727-4wfhuvww	89	7	2007	2007	CD
cord-291727-4wfhuvww	89	8	)	)	-RRB-
cord-291727-4wfhuvww	89	9	.	.	.
cord-291727-4wfhuvww	90	1	However	however	RB
cord-291727-4wfhuvww	90	2	,	,	,
cord-291727-4wfhuvww	90	3	it	-PRON-	PRP
cord-291727-4wfhuvww	90	4	is	be	VBZ
cord-291727-4wfhuvww	90	5	becoming	become	VBG
cord-291727-4wfhuvww	90	6	increasingly	increasingly	RB
cord-291727-4wfhuvww	90	7	recognized	recognize	VBN
cord-291727-4wfhuvww	90	8	that	that	IN
cord-291727-4wfhuvww	90	9	programmed	program	VBN
cord-291727-4wfhuvww	90	10	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	90	11	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	90	12	can	can	MD
cord-291727-4wfhuvww	90	13	result	result	VB
cord-291727-4wfhuvww	90	14	in	in	IN
cord-291727-4wfhuvww	90	15	peptides	peptide	NNS
cord-291727-4wfhuvww	90	16	or	or	CC
cord-291727-4wfhuvww	90	17	proteins	protein	NNS
cord-291727-4wfhuvww	90	18	with	with	IN
cord-291727-4wfhuvww	90	19	physiological	physiological	JJ
cord-291727-4wfhuvww	90	20	functions	function	NNS
cord-291727-4wfhuvww	90	21	(	(	-LRB-
cord-291727-4wfhuvww	90	22	Dinman	Dinman	NNP
cord-291727-4wfhuvww	90	23	,	,	,
cord-291727-4wfhuvww	90	24	2012a	2012a	CD
cord-291727-4wfhuvww	90	25	)	)	-RRB-
cord-291727-4wfhuvww	90	26	.	.	.
cord-291727-4wfhuvww	91	1	One	one	CD
cord-291727-4wfhuvww	91	2	question	question	NN
cord-291727-4wfhuvww	91	3	is	be	VBZ
cord-291727-4wfhuvww	91	4	whether	whether	IN
cord-291727-4wfhuvww	91	5	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	91	6	compromises	compromise	NNS
cord-291727-4wfhuvww	91	7	the	the	DT
cord-291727-4wfhuvww	91	8	function	function	NN
cord-291727-4wfhuvww	91	9	of	of	IN
cord-291727-4wfhuvww	91	10	the	the	DT
cord-291727-4wfhuvww	91	11	original	original	JJ
cord-291727-4wfhuvww	91	12	frame	frame	NN
cord-291727-4wfhuvww	91	13	.	.	.
cord-291727-4wfhuvww	92	1	It	-PRON-	PRP
cord-291727-4wfhuvww	92	2	has	have	VBZ
cord-291727-4wfhuvww	92	3	been	be	VBN
cord-291727-4wfhuvww	92	4	proposed	propose	VBN
cord-291727-4wfhuvww	92	5	that	that	IN
cord-291727-4wfhuvww	92	6	dual	dual	JJ
cord-291727-4wfhuvww	92	7	coding	coding	NN
cord-291727-4wfhuvww	92	8	limits	limit	VBZ
cord-291727-4wfhuvww	92	9	the	the	DT
cord-291727-4wfhuvww	92	10	evolutionary	evolutionary	JJ
cord-291727-4wfhuvww	92	11	flexibility	flexibility	NN
cord-291727-4wfhuvww	92	12	of	of	IN
cord-291727-4wfhuvww	92	13	the	the	DT
cord-291727-4wfhuvww	92	14	underlying	underlying	JJ
cord-291727-4wfhuvww	92	15	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	92	16	sequence	sequence	NN
cord-291727-4wfhuvww	92	17	(	(	-LRB-
cord-291727-4wfhuvww	92	18	Firth	Firth	NNP
cord-291727-4wfhuvww	92	19	and	and	CC
cord-291727-4wfhuvww	92	20	Brown	Brown	NNP
cord-291727-4wfhuvww	92	21	,	,	,
cord-291727-4wfhuvww	92	22	2006	2006	CD
cord-291727-4wfhuvww	92	23	;	;	:
cord-291727-4wfhuvww	92	24	Rancurel	Rancurel	NNP
cord-291727-4wfhuvww	92	25	et	et	NNP
cord-291727-4wfhuvww	92	26	al	al	NNP
cord-291727-4wfhuvww	92	27	.	.	NNP
cord-291727-4wfhuvww	92	28	,	,	,
cord-291727-4wfhuvww	92	29	2009	2009	CD
cord-291727-4wfhuvww	92	30	)	)	-RRB-
cord-291727-4wfhuvww	92	31	.	.	.
cord-291727-4wfhuvww	93	1	Thus	thus	RB
cord-291727-4wfhuvww	93	2	,	,	,
cord-291727-4wfhuvww	93	3	one	one	CD
cord-291727-4wfhuvww	93	4	possibility	possibility	NN
cord-291727-4wfhuvww	93	5	may	may	MD
cord-291727-4wfhuvww	93	6	be	be	VB
cord-291727-4wfhuvww	93	7	that	that	IN
cord-291727-4wfhuvww	93	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	93	9	occurs	occur	VBZ
cord-291727-4wfhuvww	93	10	predominantly	predominantly	RB
cord-291727-4wfhuvww	93	11	in	in	IN
cord-291727-4wfhuvww	93	12	highly	highly	RB
cord-291727-4wfhuvww	93	13	conserved	conserve	VBN
cord-291727-4wfhuvww	93	14	,	,	,
cord-291727-4wfhuvww	93	15	essential	essential	JJ
cord-291727-4wfhuvww	93	16	genes	gene	NNS
cord-291727-4wfhuvww	93	17	.	.	.
cord-291727-4wfhuvww	94	1	However	however	RB
cord-291727-4wfhuvww	94	2	,	,	,
cord-291727-4wfhuvww	94	3	it	-PRON-	PRP
cord-291727-4wfhuvww	94	4	has	have	VBZ
cord-291727-4wfhuvww	94	5	been	be	VBN
cord-291727-4wfhuvww	94	6	argued	argue	VBN
cord-291727-4wfhuvww	94	7	that	that	IN
cord-291727-4wfhuvww	94	8	once	once	RB
cord-291727-4wfhuvww	94	9	a	a	DT
cord-291727-4wfhuvww	94	10	frameshift	frameshift	NN
cord-291727-4wfhuvww	94	11	event	event	NN
cord-291727-4wfhuvww	94	12	is	be	VBZ
cord-291727-4wfhuvww	94	13	released	release	VBN
cord-291727-4wfhuvww	94	14	from	from	IN
cord-291727-4wfhuvww	94	15	selective	selective	JJ
cord-291727-4wfhuvww	94	16	pressure	pressure	NN
cord-291727-4wfhuvww	94	17	,	,	,
cord-291727-4wfhuvww	94	18	as	as	IN
cord-291727-4wfhuvww	94	19	occurs	occur	NNS
cord-291727-4wfhuvww	94	20	in	in	IN
cord-291727-4wfhuvww	94	21	gene	gene	NN
cord-291727-4wfhuvww	94	22	duplication	duplication	NN
cord-291727-4wfhuvww	94	23	,	,	,
cord-291727-4wfhuvww	94	24	it	-PRON-	PRP
cord-291727-4wfhuvww	94	25	can	can	MD
cord-291727-4wfhuvww	94	26	evolve	evolve	VB
cord-291727-4wfhuvww	94	27	to	to	TO
cord-291727-4wfhuvww	94	28	produce	produce	VB
cord-291727-4wfhuvww	94	29	a	a	DT
cord-291727-4wfhuvww	94	30	beneficial	beneficial	JJ
cord-291727-4wfhuvww	94	31	functional	functional	JJ
cord-291727-4wfhuvww	94	32	protein	protein	NN
cord-291727-4wfhuvww	94	33	(	(	-LRB-
cord-291727-4wfhuvww	94	34	Raes	Raes	NNP
cord-291727-4wfhuvww	94	35	and	and	CC
cord-291727-4wfhuvww	94	36	Van	Van	NNP
cord-291727-4wfhuvww	94	37	de	de	NNP
cord-291727-4wfhuvww	94	38	Peer	Peer	NNP
cord-291727-4wfhuvww	94	39	,	,	,
cord-291727-4wfhuvww	94	40	2005	2005	CD
cord-291727-4wfhuvww	94	41	)	)	-RRB-
cord-291727-4wfhuvww	94	42	.	.	.
cord-291727-4wfhuvww	95	1	Indeed	indeed	RB
cord-291727-4wfhuvww	95	2	,	,	,
cord-291727-4wfhuvww	95	3	in	in	IN
cord-291727-4wfhuvww	95	4	some	some	DT
cord-291727-4wfhuvww	95	5	cases	case	NNS
cord-291727-4wfhuvww	95	6	,	,	,
cord-291727-4wfhuvww	95	7	novel	novel	JJ
cord-291727-4wfhuvww	95	8	genes	gene	NNS
cord-291727-4wfhuvww	95	9	seem	seem	VBP
cord-291727-4wfhuvww	95	10	to	to	TO
cord-291727-4wfhuvww	95	11	have	have	VB
cord-291727-4wfhuvww	95	12	emerged	emerge	VBN
cord-291727-4wfhuvww	95	13	by	by	IN
cord-291727-4wfhuvww	95	14	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	95	15	of	of	IN
cord-291727-4wfhuvww	95	16	a	a	DT
cord-291727-4wfhuvww	95	17	pre	pre	JJ
cord-291727-4wfhuvww	95	18	-	-	JJ
cord-291727-4wfhuvww	95	19	existing	existing	JJ
cord-291727-4wfhuvww	95	20	coding	code	VBG
cord-291727-4wfhuvww	95	21	sequence	sequence	NN
cord-291727-4wfhuvww	95	22	(	(	-LRB-
cord-291727-4wfhuvww	95	23	Ohno	Ohno	NNP
cord-291727-4wfhuvww	95	24	,	,	,
cord-291727-4wfhuvww	95	25	1984	1984	CD
cord-291727-4wfhuvww	95	26	;	;	:
cord-291727-4wfhuvww	95	27	Ranz	Ranz	NNP
cord-291727-4wfhuvww	95	28	et	et	NNP
cord-291727-4wfhuvww	95	29	al	al	NNP
cord-291727-4wfhuvww	95	30	.	.	NNP
cord-291727-4wfhuvww	95	31	,	,	,
cord-291727-4wfhuvww	95	32	2003	2003	CD
cord-291727-4wfhuvww	95	33	)	)	-RRB-
cord-291727-4wfhuvww	95	34	.	.	.
cord-291727-4wfhuvww	96	1	Moreover	moreover	RB
cord-291727-4wfhuvww	96	2	,	,	,
cord-291727-4wfhuvww	96	3	regulated	regulated	JJ
cord-291727-4wfhuvww	96	4	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	96	5	can	can	MD
cord-291727-4wfhuvww	96	6	allow	allow	VB
cord-291727-4wfhuvww	96	7	the	the	DT
cord-291727-4wfhuvww	96	8	same	same	JJ
cord-291727-4wfhuvww	96	9	gene	gene	NN
cord-291727-4wfhuvww	96	10	to	to	TO
cord-291727-4wfhuvww	96	11	produce	produce	VB
cord-291727-4wfhuvww	96	12	alternative	alternative	JJ
cord-291727-4wfhuvww	96	13	beneficial	beneficial	JJ
cord-291727-4wfhuvww	96	14	proteins	protein	NNS
cord-291727-4wfhuvww	96	15	.	.	.
cord-291727-4wfhuvww	97	1	In	in	IN
cord-291727-4wfhuvww	97	2	fact	fact	NN
cord-291727-4wfhuvww	97	3	,	,	,
cord-291727-4wfhuvww	97	4	evolutionary	evolutionary	JJ
cord-291727-4wfhuvww	97	5	studies	study	NNS
cord-291727-4wfhuvww	97	6	indicate	indicate	VBP
cord-291727-4wfhuvww	97	7	a	a	DT
cord-291727-4wfhuvww	97	8	high	high	JJ
cord-291727-4wfhuvww	97	9	abundance	abundance	NN
cord-291727-4wfhuvww	97	10	of	of	IN
cord-291727-4wfhuvww	97	11	frameshift	frameshift	NN
cord-291727-4wfhuvww	97	12	events	event	NNS
cord-291727-4wfhuvww	97	13	in	in	IN
cord-291727-4wfhuvww	97	14	human	human	NN
cord-291727-4wfhuvww	97	15	and	and	CC
cord-291727-4wfhuvww	97	16	mouse	mouse	NN
cord-291727-4wfhuvww	97	17	genomes	genome	NNS
cord-291727-4wfhuvww	97	18	that	that	WDT
cord-291727-4wfhuvww	97	19	may	may	MD
cord-291727-4wfhuvww	97	20	be	be	VB
cord-291727-4wfhuvww	97	21	linked	link	VBN
cord-291727-4wfhuvww	97	22	to	to	IN
cord-291727-4wfhuvww	97	23	an	an	DT
cord-291727-4wfhuvww	97	24	increased	increase	VBN
cord-291727-4wfhuvww	97	25	usage	usage	NN
cord-291727-4wfhuvww	97	26	of	of	IN
cord-291727-4wfhuvww	97	27	the	the	DT
cord-291727-4wfhuvww	97	28	opal	opal	JJ
cord-291727-4wfhuvww	97	29	TGA	TGA	NNP
cord-291727-4wfhuvww	97	30	stop	stop	VB
cord-291727-4wfhuvww	97	31	codon	codon	NN
cord-291727-4wfhuvww	98	1	(	(	-LRB-
cord-291727-4wfhuvww	98	2	Okamura	Okamura	NNP
cord-291727-4wfhuvww	98	3	et	et	NNP
cord-291727-4wfhuvww	98	4	al	al	NNP
cord-291727-4wfhuvww	98	5	.	.	NNP
cord-291727-4wfhuvww	98	6	,	,	,
cord-291727-4wfhuvww	98	7	2006	2006	CD
cord-291727-4wfhuvww	98	8	)	)	-RRB-
cord-291727-4wfhuvww	98	9	.	.	.
cord-291727-4wfhuvww	99	1	It	-PRON-	PRP
cord-291727-4wfhuvww	99	2	has	have	VBZ
cord-291727-4wfhuvww	99	3	been	be	VBN
cord-291727-4wfhuvww	99	4	proposed	propose	VBN
cord-291727-4wfhuvww	99	5	that	that	IN
cord-291727-4wfhuvww	99	6	at	at	RB
cord-291727-4wfhuvww	99	7	least	least	RBS
cord-291727-4wfhuvww	99	8	1	1	CD
cord-291727-4wfhuvww	99	9	%	%	NN
cord-291727-4wfhuvww	99	10	of	of	IN
cord-291727-4wfhuvww	99	11	the	the	DT
cord-291727-4wfhuvww	99	12	human	human	JJ
cord-291727-4wfhuvww	99	13	genome	genome	NN
cord-291727-4wfhuvww	99	14	consists	consist	VBZ
cord-291727-4wfhuvww	99	15	of	of	IN
cord-291727-4wfhuvww	99	16	dual	dual	JJ
cord-291727-4wfhuvww	99	17	coding	coding	NN
cord-291727-4wfhuvww	99	18	regions	region	NNS
cord-291727-4wfhuvww	99	19	(	(	-LRB-
cord-291727-4wfhuvww	99	20	Michel	Michel	NNP
cord-291727-4wfhuvww	99	21	et	et	NNP
cord-291727-4wfhuvww	99	22	al	al	NNP
cord-291727-4wfhuvww	99	23	.	.	NNP
cord-291727-4wfhuvww	99	24	,	,	,
cord-291727-4wfhuvww	99	25	2012	2012	CD
cord-291727-4wfhuvww	99	26	)	)	-RRB-
cord-291727-4wfhuvww	99	27	and	and	CC
cord-291727-4wfhuvww	99	28	that	that	IN
cord-291727-4wfhuvww	99	29	the	the	DT
cord-291727-4wfhuvww	99	30	number	number	NN
cord-291727-4wfhuvww	99	31	of	of	IN
cord-291727-4wfhuvww	99	32	out	out	IN
cord-291727-4wfhuvww	99	33	-	-	HYPH
cord-291727-4wfhuvww	99	34	of	of	IN
cord-291727-4wfhuvww	99	35	-	-	HYPH
cord-291727-4wfhuvww	99	36	frame	frame	NN
cord-291727-4wfhuvww	99	37	peptides	peptide	NNS
cord-291727-4wfhuvww	99	38	or	or	CC
cord-291727-4wfhuvww	99	39	proteins	protein	NNS
cord-291727-4wfhuvww	99	40	may	may	MD
cord-291727-4wfhuvww	99	41	be	be	VB
cord-291727-4wfhuvww	99	42	even	even	RB
cord-291727-4wfhuvww	99	43	higher	high	JJR
cord-291727-4wfhuvww	99	44	than	than	IN
cord-291727-4wfhuvww	99	45	that	that	DT
cord-291727-4wfhuvww	99	46	.	.	.
cord-291727-4wfhuvww	100	1	Other	other	JJ
cord-291727-4wfhuvww	100	2	studies	study	NNS
cord-291727-4wfhuvww	100	3	have	have	VBP
cord-291727-4wfhuvww	100	4	suggested	suggest	VBN
cord-291727-4wfhuvww	100	5	that	that	IN
cord-291727-4wfhuvww	100	6	∼10	∼10	NN
cord-291727-4wfhuvww	100	7	%	%	NN
cord-291727-4wfhuvww	100	8	of	of	IN
cord-291727-4wfhuvww	100	9	the	the	DT
cord-291727-4wfhuvww	100	10	genome	genome	NN
cord-291727-4wfhuvww	100	11	contains	contain	VBZ
cord-291727-4wfhuvww	100	12	−1	−1	NNP
cord-291727-4wfhuvww	100	13	frameshift	frameshift	NN
cord-291727-4wfhuvww	100	14	signals	signal	NNS
cord-291727-4wfhuvww	100	15	(	(	-LRB-
cord-291727-4wfhuvww	101	1	Belew	Belew	NNP
cord-291727-4wfhuvww	101	2	et	et	NNP
cord-291727-4wfhuvww	101	3	al	al	NNP
cord-291727-4wfhuvww	101	4	.	.	.
cord-291727-4wfhuvww	102	1	,	,	,
cord-291727-4wfhuvww	102	2	2011	2011	CD
cord-291727-4wfhuvww	102	3	)	)	-RRB-
cord-291727-4wfhuvww	102	4	.	.	.
cord-291727-4wfhuvww	103	1	I	-PRON-	PRP
cord-291727-4wfhuvww	103	2	would	would	MD
cord-291727-4wfhuvww	103	3	argue	argue	VB
cord-291727-4wfhuvww	103	4	that	that	IN
cord-291727-4wfhuvww	103	5	the	the	DT
cord-291727-4wfhuvww	103	6	number	number	NN
cord-291727-4wfhuvww	103	7	of	of	IN
cord-291727-4wfhuvww	103	8	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	103	9	peptides	peptide	NNS
cord-291727-4wfhuvww	103	10	or	or	CC
cord-291727-4wfhuvww	103	11	proteins	protein	NNS
cord-291727-4wfhuvww	103	12	is	be	VBZ
cord-291727-4wfhuvww	103	13	somewhere	somewhere	RB
cord-291727-4wfhuvww	103	14	in	in	IN
cord-291727-4wfhuvww	103	15	the	the	DT
cord-291727-4wfhuvww	103	16	range	range	NN
cord-291727-4wfhuvww	103	17	of	of	IN
cord-291727-4wfhuvww	103	18	1	1	CD
cord-291727-4wfhuvww	103	19	-	-	SYM
cord-291727-4wfhuvww	103	20	10	10	CD
cord-291727-4wfhuvww	103	21	%	%	NN
cord-291727-4wfhuvww	103	22	of	of	IN
cord-291727-4wfhuvww	103	23	the	the	DT
cord-291727-4wfhuvww	103	24	genome	genome	NN
cord-291727-4wfhuvww	103	25	.	.	.
cord-291727-4wfhuvww	104	1	This	this	DT
cord-291727-4wfhuvww	104	2	is	be	VBZ
cord-291727-4wfhuvww	104	3	a	a	DT
cord-291727-4wfhuvww	104	4	very	very	RB
cord-291727-4wfhuvww	104	5	significant	significant	JJ
cord-291727-4wfhuvww	104	6	fraction	fraction	NN
cord-291727-4wfhuvww	104	7	of	of	IN
cord-291727-4wfhuvww	104	8	the	the	DT
cord-291727-4wfhuvww	104	9	genome	genome	NN
cord-291727-4wfhuvww	104	10	,	,	,
cord-291727-4wfhuvww	104	11	thus	thus	RB
cord-291727-4wfhuvww	104	12	suggesting	suggest	VBG
cord-291727-4wfhuvww	104	13	that	that	IN
cord-291727-4wfhuvww	104	14	out	out	IN
cord-291727-4wfhuvww	104	15	-	-	HYPH
cord-291727-4wfhuvww	104	16	offrame	offrame	NN
cord-291727-4wfhuvww	104	17	peptides	peptide	NNS
cord-291727-4wfhuvww	104	18	are	be	VBP
cord-291727-4wfhuvww	104	19	an	an	DT
cord-291727-4wfhuvww	104	20	inherent	inherent	JJ
cord-291727-4wfhuvww	104	21	part	part	NN
cord-291727-4wfhuvww	104	22	of	of	IN
cord-291727-4wfhuvww	104	23	animal	animal	NN
cord-291727-4wfhuvww	104	24	physiology	physiology	NN
cord-291727-4wfhuvww	104	25	and	and	CC
cord-291727-4wfhuvww	104	26	part	part	NN
cord-291727-4wfhuvww	104	27	of	of	IN
cord-291727-4wfhuvww	104	28	evolutionary	evolutionary	JJ
cord-291727-4wfhuvww	104	29	selection	selection	NN
cord-291727-4wfhuvww	104	30	processes	process	NNS
cord-291727-4wfhuvww	104	31	.	.	.
cord-291727-4wfhuvww	105	1	Accordingly	accordingly	RB
cord-291727-4wfhuvww	105	2	,	,	,
cord-291727-4wfhuvww	105	3	it	-PRON-	PRP
cord-291727-4wfhuvww	105	4	can	can	MD
cord-291727-4wfhuvww	105	5	be	be	VB
cord-291727-4wfhuvww	105	6	anticipated	anticipate	VBN
cord-291727-4wfhuvww	105	7	that	that	IN
cord-291727-4wfhuvww	105	8	dual	dual	JJ
cord-291727-4wfhuvww	105	9	coding	coding	NN
cord-291727-4wfhuvww	105	10	is	be	VBZ
cord-291727-4wfhuvww	105	11	regulated	regulate	VBN
cord-291727-4wfhuvww	105	12	and	and	CC
cord-291727-4wfhuvww	105	13	a	a	DT
cord-291727-4wfhuvww	105	14	common	common	JJ
cord-291727-4wfhuvww	105	15	mechanism	mechanism	NN
cord-291727-4wfhuvww	105	16	for	for	IN
cord-291727-4wfhuvww	105	17	producing	produce	VBG
cord-291727-4wfhuvww	105	18	additional	additional	JJ
cord-291727-4wfhuvww	105	19	gene	gene	NN
cord-291727-4wfhuvww	105	20	products	product	NNS
cord-291727-4wfhuvww	105	21	.	.	.
cord-291727-4wfhuvww	106	1	The	the	DT
cord-291727-4wfhuvww	106	2	main	main	JJ
cord-291727-4wfhuvww	106	3	questions	question	NNS
cord-291727-4wfhuvww	106	4	are	be	VBP
cord-291727-4wfhuvww	106	5	:	:	:
cord-291727-4wfhuvww	106	6	1	1	CD
cord-291727-4wfhuvww	106	7	.	.	.
cord-291727-4wfhuvww	107	1	What	what	WP
cord-291727-4wfhuvww	107	2	is	be	VBZ
cord-291727-4wfhuvww	107	3	the	the	DT
cord-291727-4wfhuvww	107	4	sequence	sequence	NN
cord-291727-4wfhuvww	107	5	or	or	CC
cord-291727-4wfhuvww	107	6	structural	structural	JJ
cord-291727-4wfhuvww	107	7	motif	motif	NN
cord-291727-4wfhuvww	107	8	for	for	IN
cord-291727-4wfhuvww	107	9	dual	dual	JJ
cord-291727-4wfhuvww	107	10	coding	coding	NN
cord-291727-4wfhuvww	107	11	?	?	.
cord-291727-4wfhuvww	108	1	2	2	LS
cord-291727-4wfhuvww	108	2	.	.	.
cord-291727-4wfhuvww	109	1	What	what	WP
cord-291727-4wfhuvww	109	2	is	be	VBZ
cord-291727-4wfhuvww	109	3	the	the	DT
cord-291727-4wfhuvww	109	4	identity	identity	NN
cord-291727-4wfhuvww	109	5	of	of	IN
cord-291727-4wfhuvww	109	6	all	all	DT
cord-291727-4wfhuvww	109	7	dual	dual	RB
cord-291727-4wfhuvww	109	8	-	-	HYPH
cord-291727-4wfhuvww	109	9	coding	code	VBG
cord-291727-4wfhuvww	109	10	genes	gene	NNS
cord-291727-4wfhuvww	109	11	and	and	CC
cord-291727-4wfhuvww	109	12	out	out	RB
cord-291727-4wfhuvww	109	13	-	-	HYPH
cord-291727-4wfhuvww	109	14	of	of	IN
cord-291727-4wfhuvww	109	15	-	-	HYPH
cord-291727-4wfhuvww	109	16	frame	frame	NN
cord-291727-4wfhuvww	109	17	proteins	protein	NNS
cord-291727-4wfhuvww	109	18	in	in	IN
cord-291727-4wfhuvww	109	19	the	the	DT
cord-291727-4wfhuvww	109	20	genome	genome	NN
cord-291727-4wfhuvww	109	21	?	?	.
cord-291727-4wfhuvww	110	1	3	3	LS
cord-291727-4wfhuvww	110	2	.	.	.
cord-291727-4wfhuvww	111	1	How	how	WRB
cord-291727-4wfhuvww	111	2	is	be	VBZ
cord-291727-4wfhuvww	111	3	dual	dual	JJ
cord-291727-4wfhuvww	111	4	coding	code	VBG
cord-291727-4wfhuvww	111	5	regulated	regulate	VBN
cord-291727-4wfhuvww	111	6	?	?	.
cord-291727-4wfhuvww	112	1	To	to	TO
cord-291727-4wfhuvww	112	2	answer	answer	VB
cord-291727-4wfhuvww	112	3	these	these	DT
cord-291727-4wfhuvww	112	4	questions	question	NNS
cord-291727-4wfhuvww	112	5	,	,	,
cord-291727-4wfhuvww	112	6	we	-PRON-	PRP
cord-291727-4wfhuvww	112	7	need	need	VBP
cord-291727-4wfhuvww	112	8	to	to	TO
cord-291727-4wfhuvww	112	9	look	look	VB
cord-291727-4wfhuvww	112	10	at	at	IN
cord-291727-4wfhuvww	112	11	commonly	commonly	RB
cord-291727-4wfhuvww	112	12	used	use	VBN
cord-291727-4wfhuvww	112	13	methods	method	NNS
cord-291727-4wfhuvww	112	14	to	to	TO
cord-291727-4wfhuvww	112	15	identify	identify	VB
cord-291727-4wfhuvww	112	16	frameshift	frameshift	NN
cord-291727-4wfhuvww	112	17	events	event	NNS
cord-291727-4wfhuvww	112	18	and	and	CC
cord-291727-4wfhuvww	112	19	out	out	RB
cord-291727-4wfhuvww	112	20	-	-	HYPH
cord-291727-4wfhuvww	112	21	of	of	IN
cord-291727-4wfhuvww	112	22	-	-	HYPH
cord-291727-4wfhuvww	112	23	frame	frame	NN
cord-291727-4wfhuvww	112	24	peptides	peptide	NNS
cord-291727-4wfhuvww	112	25	and	and	CC
cord-291727-4wfhuvww	112	26	proteins	protein	NNS
cord-291727-4wfhuvww	112	27	.	.	.
cord-291727-4wfhuvww	113	1	Soon	soon	RB
cord-291727-4wfhuvww	113	2	after	after	IN
cord-291727-4wfhuvww	113	3	the	the	DT
cord-291727-4wfhuvww	113	4	discovery	discovery	NN
cord-291727-4wfhuvww	113	5	of	of	IN
cord-291727-4wfhuvww	113	6	programmed	program	VBN
cord-291727-4wfhuvww	113	7	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	113	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	113	9	,	,	,
cord-291727-4wfhuvww	113	10	it	-PRON-	PRP
cord-291727-4wfhuvww	113	11	was	be	VBD
cord-291727-4wfhuvww	113	12	proposed	propose	VBN
cord-291727-4wfhuvww	113	13	that	that	IN
cord-291727-4wfhuvww	113	14	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	113	15	may	may	MD
cord-291727-4wfhuvww	113	16	be	be	VB
cord-291727-4wfhuvww	113	17	a	a	DT
cord-291727-4wfhuvww	113	18	common	common	JJ
cord-291727-4wfhuvww	113	19	mechanism	mechanism	NN
cord-291727-4wfhuvww	113	20	for	for	IN
cord-291727-4wfhuvww	113	21	dual	dual	JJ
cord-291727-4wfhuvww	113	22	decoding	decoding	NN
cord-291727-4wfhuvww	113	23	of	of	IN
cord-291727-4wfhuvww	113	24	genetic	genetic	JJ
cord-291727-4wfhuvww	113	25	information	information	NN
cord-291727-4wfhuvww	113	26	(	(	-LRB-
cord-291727-4wfhuvww	113	27	Dinman	Dinman	NNP
cord-291727-4wfhuvww	113	28	,	,	,
cord-291727-4wfhuvww	113	29	2012a	2012a	CD
cord-291727-4wfhuvww	113	30	)	)	-RRB-
cord-291727-4wfhuvww	113	31	.	.	.
cord-291727-4wfhuvww	114	1	The	the	DT
cord-291727-4wfhuvww	114	2	existence	existence	NN
cord-291727-4wfhuvww	114	3	of	of	IN
cord-291727-4wfhuvww	114	4	an	an	DT
cord-291727-4wfhuvww	114	5	alternative	alternative	JJ
cord-291727-4wfhuvww	114	6	genome	genome	NN
cord-291727-4wfhuvww	114	7	has	have	VBZ
cord-291727-4wfhuvww	114	8	been	be	VBN
cord-291727-4wfhuvww	114	9	postulated	postulate	VBN
cord-291727-4wfhuvww	114	10	,	,	,
cord-291727-4wfhuvww	114	11	but	but	CC
cord-291727-4wfhuvww	114	12	it	-PRON-	PRP
cord-291727-4wfhuvww	114	13	has	have	VBZ
cord-291727-4wfhuvww	114	14	remained	remain	VBN
cord-291727-4wfhuvww	114	15	difficult	difficult	JJ
cord-291727-4wfhuvww	114	16	to	to	TO
cord-291727-4wfhuvww	114	17	identify	identify	VB
cord-291727-4wfhuvww	114	18	.	.	.
cord-291727-4wfhuvww	115	1	Most	Most	JJS
cord-291727-4wfhuvww	115	2	methods	method	NNS
cord-291727-4wfhuvww	115	3	aim	aim	VBP
cord-291727-4wfhuvww	115	4	to	to	TO
cord-291727-4wfhuvww	115	5	identify	identify	VB
cord-291727-4wfhuvww	115	6	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	115	7	events	event	NNS
cord-291727-4wfhuvww	115	8	,	,	,
cord-291727-4wfhuvww	115	9	but	but	CC
cord-291727-4wfhuvww	115	10	very	very	RB
cord-291727-4wfhuvww	115	11	few	few	JJ
cord-291727-4wfhuvww	115	12	can	can	MD
cord-291727-4wfhuvww	115	13	determine	determine	VB
cord-291727-4wfhuvww	115	14	which	which	WDT
cord-291727-4wfhuvww	115	15	produce	produce	VB
cord-291727-4wfhuvww	115	16	functional	functional	JJ
cord-291727-4wfhuvww	115	17	out	out	RB
cord-291727-4wfhuvww	115	18	-	-	HYPH
cord-291727-4wfhuvww	115	19	of	of	IN
cord-291727-4wfhuvww	115	20	-	-	HYPH
cord-291727-4wfhuvww	115	21	frame	frame	NN
cord-291727-4wfhuvww	115	22	gene	gene	NN
cord-291727-4wfhuvww	115	23	products	product	NNS
cord-291727-4wfhuvww	115	24	.	.	.
cord-291727-4wfhuvww	116	1	A	a	DT
cord-291727-4wfhuvww	116	2	summary	summary	NN
cord-291727-4wfhuvww	116	3	of	of	IN
cord-291727-4wfhuvww	116	4	methods	method	NNS
cord-291727-4wfhuvww	116	5	to	to	TO
cord-291727-4wfhuvww	116	6	identify	identify	VB
cord-291727-4wfhuvww	116	7	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	116	8	events	event	NNS
cord-291727-4wfhuvww	116	9	in	in	IN
cord-291727-4wfhuvww	116	10	mRNAs	mrnas	CD
cord-291727-4wfhuvww	116	11	and	and	CC
cord-291727-4wfhuvww	116	12	out	out	RB
cord-291727-4wfhuvww	116	13	-	-	HYPH
cord-291727-4wfhuvww	116	14	of	of	IN
cord-291727-4wfhuvww	116	15	-	-	HYPH
cord-291727-4wfhuvww	116	16	frame	frame	NN
cord-291727-4wfhuvww	116	17	products	product	NNS
cord-291727-4wfhuvww	116	18	is	be	VBZ
cord-291727-4wfhuvww	116	19	schematically	schematically	RB
cord-291727-4wfhuvww	116	20	shown	show	VBN
cord-291727-4wfhuvww	116	21	in	in	IN
cord-291727-4wfhuvww	116	22	Figure	figure	NN
cord-291727-4wfhuvww	116	23	3	3	CD
cord-291727-4wfhuvww	116	24	.	.	.
cord-291727-4wfhuvww	117	1	Computational	computational	JJ
cord-291727-4wfhuvww	117	2	prediction	prediction	NN
cord-291727-4wfhuvww	117	3	has	have	VBZ
cord-291727-4wfhuvww	117	4	proven	prove	VBN
cord-291727-4wfhuvww	117	5	very	very	RB
cord-291727-4wfhuvww	117	6	useful	useful	JJ
cord-291727-4wfhuvww	117	7	.	.	.
cord-291727-4wfhuvww	118	1	First	first	RB
cord-291727-4wfhuvww	118	2	,	,	,
cord-291727-4wfhuvww	118	3	one	one	PRP
cord-291727-4wfhuvww	118	4	has	have	VBZ
cord-291727-4wfhuvww	118	5	to	to	TO
cord-291727-4wfhuvww	118	6	identify	identify	VB
cord-291727-4wfhuvww	118	7	in	in	IN
cord-291727-4wfhuvww	118	8	mRNAs	mRNAs	NNPS
cord-291727-4wfhuvww	118	9	the	the	DT
cord-291727-4wfhuvww	118	10	requirements	requirement	NNS
cord-291727-4wfhuvww	118	11	for	for	IN
cord-291727-4wfhuvww	118	12	a	a	DT
cord-291727-4wfhuvww	118	13	productive	productive	JJ
cord-291727-4wfhuvww	118	14	frameshift	frameshift	NN
cord-291727-4wfhuvww	118	15	peptide	peptide	NN
cord-291727-4wfhuvww	118	16	:	:	:
cord-291727-4wfhuvww	118	17	One	one	PRP
cord-291727-4wfhuvww	118	18	might	may	MD
cord-291727-4wfhuvww	118	19	argue	argue	VB
cord-291727-4wfhuvww	118	20	that	that	IN
cord-291727-4wfhuvww	118	21	a	a	DT
cord-291727-4wfhuvww	118	22	slippery	slippery	JJ
cord-291727-4wfhuvww	118	23	sequence	sequence	NN
cord-291727-4wfhuvww	118	24	and	and	CC
cord-291727-4wfhuvww	118	25	a	a	DT
cord-291727-4wfhuvww	118	26	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	118	27	are	be	VBP
cord-291727-4wfhuvww	118	28	a	a	DT
cord-291727-4wfhuvww	118	29	good	good	JJ
cord-291727-4wfhuvww	118	30	predictor	predictor	NN
cord-291727-4wfhuvww	118	31	of	of	IN
cord-291727-4wfhuvww	118	32	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	118	33	events	event	NNS
cord-291727-4wfhuvww	118	34	,	,	,
cord-291727-4wfhuvww	118	35	but	but	CC
cord-291727-4wfhuvww	118	36	-	-	:
cord-291727-4wfhuvww	118	37	as	as	RB
cord-291727-4wfhuvww	118	38	pointed	point	VBN
cord-291727-4wfhuvww	118	39	out	out	RP
cord-291727-4wfhuvww	118	40	above	above	RB
cord-291727-4wfhuvww	118	41	-	-	:
cord-291727-4wfhuvww	118	42	there	there	EX
cord-291727-4wfhuvww	118	43	are	be	VBP
cord-291727-4wfhuvww	118	44	alternative	alternative	JJ
cord-291727-4wfhuvww	118	45	mechanisms	mechanism	NNS
cord-291727-4wfhuvww	118	46	that	that	WDT
cord-291727-4wfhuvww	118	47	result	result	VBP
cord-291727-4wfhuvww	118	48	in	in	IN
cord-291727-4wfhuvww	118	49	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	118	50	(	(	-LRB-
cord-291727-4wfhuvww	118	51	see	see	VB
cord-291727-4wfhuvww	118	52	also	also	RB
cord-291727-4wfhuvww	118	53	Figure	figure	NN
cord-291727-4wfhuvww	118	54	2	2	CD
cord-291727-4wfhuvww	118	55	)	)	-RRB-
cord-291727-4wfhuvww	118	56	.	.	.
cord-291727-4wfhuvww	119	1	For	for	IN
cord-291727-4wfhuvww	119	2	identification	identification	NN
cord-291727-4wfhuvww	119	3	of	of	IN
cord-291727-4wfhuvww	119	4	the	the	DT
cord-291727-4wfhuvww	119	5	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	119	6	products	product	NNS
cord-291727-4wfhuvww	119	7	,	,	,
cord-291727-4wfhuvww	119	8	I	-PRON-	PRP
cord-291727-4wfhuvww	119	9	propose	propose	VBP
cord-291727-4wfhuvww	119	10	three	three	CD
cord-291727-4wfhuvww	119	11	hallmarks	hallmark	NNS
cord-291727-4wfhuvww	119	12	:	:	:
cord-291727-4wfhuvww	119	13	first	first	RB
cord-291727-4wfhuvww	119	14	,	,	,
cord-291727-4wfhuvww	119	15	the	the	DT
cord-291727-4wfhuvww	119	16	presence	presence	NN
cord-291727-4wfhuvww	119	17	of	of	IN
cord-291727-4wfhuvww	119	18	an	an	DT
cord-291727-4wfhuvww	119	19	initiation	initiation	NN
cord-291727-4wfhuvww	119	20	triplet	triplet	NN
cord-291727-4wfhuvww	119	21	(	(	-LRB-
cord-291727-4wfhuvww	119	22	AUG	AUG	NNP
cord-291727-4wfhuvww	119	23	or	or	CC
cord-291727-4wfhuvww	119	24	CUG	CUG	NNP
cord-291727-4wfhuvww	119	25	)	)	-RRB-
cord-291727-4wfhuvww	119	26	and	and	CC
cord-291727-4wfhuvww	119	27	a	a	DT
cord-291727-4wfhuvww	119	28	stop	stop	NN
cord-291727-4wfhuvww	119	29	codon	codon	NN
cord-291727-4wfhuvww	119	30	in	in	IN
cord-291727-4wfhuvww	119	31	+1	+1	HYPH
cord-291727-4wfhuvww	119	32	or	or	CC
cord-291727-4wfhuvww	119	33	−1	−1	NNP
cord-291727-4wfhuvww	119	34	frame	frame	NN
cord-291727-4wfhuvww	119	35	;	;	:
cord-291727-4wfhuvww	119	36	second	second	RB
cord-291727-4wfhuvww	119	37	,	,	,
cord-291727-4wfhuvww	119	38	a	a	DT
cord-291727-4wfhuvww	119	39	stable	stable	JJ
cord-291727-4wfhuvww	119	40	peptide	peptide	NN
cord-291727-4wfhuvww	119	41	that	that	WDT
cord-291727-4wfhuvww	119	42	follows	follow	VBZ
cord-291727-4wfhuvww	119	43	the	the	DT
cord-291727-4wfhuvww	119	44	50-nt	50-nt	CD
cord-291727-4wfhuvww	119	45	rule	rule	NN
cord-291727-4wfhuvww	119	46	(	(	-LRB-
cord-291727-4wfhuvww	119	47	Nagy	Nagy	NNP
cord-291727-4wfhuvww	119	48	and	and	CC
cord-291727-4wfhuvww	119	49	Maquat	Maquat	NNP
cord-291727-4wfhuvww	119	50	,	,	,
cord-291727-4wfhuvww	119	51	1998	1998	CD
cord-291727-4wfhuvww	119	52	;	;	:
cord-291727-4wfhuvww	120	1	Hillman	Hillman	NNP
cord-291727-4wfhuvww	120	2	et	et	NNP
cord-291727-4wfhuvww	120	3	al	al	NNP
cord-291727-4wfhuvww	120	4	.	.	NNP
cord-291727-4wfhuvww	120	5	,	,	,
cord-291727-4wfhuvww	120	6	2004	2004	CD
cord-291727-4wfhuvww	120	7	)	)	-RRB-
cord-291727-4wfhuvww	120	8	;	;	:
cord-291727-4wfhuvww	120	9	and	and	CC
cord-291727-4wfhuvww	120	10	third	third	RB
cord-291727-4wfhuvww	120	11	,	,	,
cord-291727-4wfhuvww	120	12	the	the	DT
cord-291727-4wfhuvww	120	13	validation	validation	NN
cord-291727-4wfhuvww	120	14	that	that	WDT
cord-291727-4wfhuvww	120	15	the	the	DT
cord-291727-4wfhuvww	120	16	peptide	peptide	NN
cord-291727-4wfhuvww	120	17	is	be	VBZ
cord-291727-4wfhuvww	120	18	endogenously	endogenously	RB
cord-291727-4wfhuvww	120	19	expressed	express	VBN
cord-291727-4wfhuvww	120	20	.	.	.
cord-291727-4wfhuvww	121	1	Validation	validation	NN
cord-291727-4wfhuvww	121	2	can	can	MD
cord-291727-4wfhuvww	121	3	be	be	VB
cord-291727-4wfhuvww	121	4	done	do	VBN
cord-291727-4wfhuvww	121	5	by	by	IN
cord-291727-4wfhuvww	121	6	low	low	JJ
cord-291727-4wfhuvww	121	7	-	-	HYPH
cord-291727-4wfhuvww	121	8	throughput	throughput	NN
cord-291727-4wfhuvww	121	9	experimental	experimental	JJ
cord-291727-4wfhuvww	121	10	methods	method	NNS
cord-291727-4wfhuvww	121	11	,	,	,
cord-291727-4wfhuvww	121	12	either	either	CC
cord-291727-4wfhuvww	121	13	using	use	VBG
cord-291727-4wfhuvww	121	14	antibodies	antibody	NNS
cord-291727-4wfhuvww	121	15	raised	raise	VBN
cord-291727-4wfhuvww	121	16	against	against	IN
cord-291727-4wfhuvww	121	17	the	the	DT
cord-291727-4wfhuvww	121	18	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	121	19	protein	protein	NN
cord-291727-4wfhuvww	121	20	or	or	CC
cord-291727-4wfhuvww	121	21	using	use	VBG
cord-291727-4wfhuvww	121	22	genetic	genetic	JJ
cord-291727-4wfhuvww	121	23	manipulations	manipulation	NNS
cord-291727-4wfhuvww	121	24	that	that	WDT
cord-291727-4wfhuvww	121	25	ablate	ablate	VBP
cord-291727-4wfhuvww	121	26	the	the	DT
cord-291727-4wfhuvww	121	27	frameshift	frameshift	NN
cord-291727-4wfhuvww	121	28	protein	protein	NN
cord-291727-4wfhuvww	121	29	without	without	IN
cord-291727-4wfhuvww	121	30	disrupting	disrupt	VBG
cord-291727-4wfhuvww	121	31	the	the	DT
cord-291727-4wfhuvww	121	32	zero	zero	CD
cord-291727-4wfhuvww	121	33	frame	frame	NN
cord-291727-4wfhuvww	121	34	protein	protein	NN
cord-291727-4wfhuvww	121	35	,	,	,
cord-291727-4wfhuvww	121	36	if	if	IN
cord-291727-4wfhuvww	121	37	possible	possible	JJ
cord-291727-4wfhuvww	121	38	.	.	.
cord-291727-4wfhuvww	122	1	To	to	TO
cord-291727-4wfhuvww	122	2	identify	identify	VB
cord-291727-4wfhuvww	122	3	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	122	4	on	on	IN
cord-291727-4wfhuvww	122	5	a	a	DT
cord-291727-4wfhuvww	122	6	genome	genome	NN
cord-291727-4wfhuvww	122	7	-	-	HYPH
cord-291727-4wfhuvww	122	8	wide	wide	JJ
cord-291727-4wfhuvww	122	9	scale	scale	NN
cord-291727-4wfhuvww	122	10	,	,	,
cord-291727-4wfhuvww	122	11	higher	high	JJR
cord-291727-4wfhuvww	122	12	throughput	throughput	NN
cord-291727-4wfhuvww	122	13	approaches	approach	NNS
cord-291727-4wfhuvww	122	14	can	can	MD
cord-291727-4wfhuvww	122	15	be	be	VB
cord-291727-4wfhuvww	122	16	applied	apply	VBN
cord-291727-4wfhuvww	122	17	,	,	,
cord-291727-4wfhuvww	122	18	such	such	JJ
cord-291727-4wfhuvww	122	19	as	as	IN
cord-291727-4wfhuvww	122	20	genomic	genomic	JJ
cord-291727-4wfhuvww	122	21	,	,	,
cord-291727-4wfhuvww	122	22	phenotypic	phenotypic	JJ
cord-291727-4wfhuvww	122	23	,	,	,
cord-291727-4wfhuvww	122	24	or	or	CC
cord-291727-4wfhuvww	122	25	proteomic	proteomic	JJ
cord-291727-4wfhuvww	122	26	screening	screening	NN
cord-291727-4wfhuvww	122	27	.	.	.
cord-291727-4wfhuvww	123	1	Several	several	JJ
cord-291727-4wfhuvww	123	2	databases	database	NNS
cord-291727-4wfhuvww	123	3	have	have	VBP
cord-291727-4wfhuvww	123	4	been	be	VBN
cord-291727-4wfhuvww	123	5	created	create	VBN
cord-291727-4wfhuvww	123	6	to	to	TO
cord-291727-4wfhuvww	123	7	help	help	VB
cord-291727-4wfhuvww	123	8	predict	predict	VB
cord-291727-4wfhuvww	123	9	frameshift	frameshift	NN
cord-291727-4wfhuvww	123	10	sequences	sequence	NNS
cord-291727-4wfhuvww	123	11	in	in	IN
cord-291727-4wfhuvww	123	12	the	the	DT
cord-291727-4wfhuvww	123	13	genome	genome	NN
cord-291727-4wfhuvww	123	14	.	.	.
cord-291727-4wfhuvww	124	1	Such	such	JJ
cord-291727-4wfhuvww	124	2	predictions	prediction	NNS
cord-291727-4wfhuvww	124	3	are	be	VBP
cord-291727-4wfhuvww	124	4	based	base	VBN
cord-291727-4wfhuvww	124	5	on	on	IN
cord-291727-4wfhuvww	124	6	primary	primary	JJ
cord-291727-4wfhuvww	124	7	mRNA	mRNA	NNP
cord-291727-4wfhuvww	124	8	sequence	sequence	NN
cord-291727-4wfhuvww	124	9	stretches	stretch	VBZ
cord-291727-4wfhuvww	124	10	or	or	CC
cord-291727-4wfhuvww	124	11	on	on	IN
cord-291727-4wfhuvww	124	12	secondary	secondary	JJ
cord-291727-4wfhuvww	124	13	hairpins	hairpin	NNS
cord-291727-4wfhuvww	124	14	or	or	CC
cord-291727-4wfhuvww	124	15	pseudo	pseudo	JJ
cord-291727-4wfhuvww	124	16	-	-	NNS
cord-291727-4wfhuvww	124	17	knots	knot	NNS
cord-291727-4wfhuvww	124	18	within	within	IN
cord-291727-4wfhuvww	124	19	the	the	DT
cord-291727-4wfhuvww	124	20	mRNA	mRNA	NNP
cord-291727-4wfhuvww	124	21	sequence	sequence	NN
cord-291727-4wfhuvww	124	22	.	.	.
cord-291727-4wfhuvww	125	1	For	for	IN
cord-291727-4wfhuvww	125	2	instance	instance	NN
cord-291727-4wfhuvww	125	3	,	,	,
cord-291727-4wfhuvww	125	4	Hammell	Hammell	NNP
cord-291727-4wfhuvww	125	5	et	et	NNP
cord-291727-4wfhuvww	125	6	al	al	NNP
cord-291727-4wfhuvww	125	7	.	.	NNP
cord-291727-4wfhuvww	125	8	searched	search	VBD
cord-291727-4wfhuvww	125	9	the	the	DT
cord-291727-4wfhuvww	125	10	genome	genome	NN
cord-291727-4wfhuvww	125	11	for	for	IN
cord-291727-4wfhuvww	125	12	slippery	slippery	JJ
cord-291727-4wfhuvww	125	13	sequences	sequence	NNS
cord-291727-4wfhuvww	125	14	and	and	CC
cord-291727-4wfhuvww	125	15	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	125	16	FIGURE	FIGURE	NNP
cord-291727-4wfhuvww	125	17	3	3	CD
cord-291727-4wfhuvww	125	18	|	|	NNP
cord-291727-4wfhuvww	125	19	Methods	Methods	NNPS
cord-291727-4wfhuvww	125	20	to	to	TO
cord-291727-4wfhuvww	125	21	detect	detect	VB
cord-291727-4wfhuvww	125	22	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	125	23	events	event	NNS
cord-291727-4wfhuvww	125	24	and	and	CC
cord-291727-4wfhuvww	125	25	out	out	RB
cord-291727-4wfhuvww	125	26	-	-	HYPH
cord-291727-4wfhuvww	125	27	of	of	IN
cord-291727-4wfhuvww	125	28	-	-	HYPH
cord-291727-4wfhuvww	125	29	frame	frame	NN
cord-291727-4wfhuvww	125	30	peptides	peptide	NNS
cord-291727-4wfhuvww	125	31	.	.	.
cord-291727-4wfhuvww	126	1	Computational	computational	JJ
cord-291727-4wfhuvww	126	2	methods	method	NNS
cord-291727-4wfhuvww	126	3	(	(	-LRB-
cord-291727-4wfhuvww	126	4	1	1	LS
cord-291727-4wfhuvww	126	5	)	)	-RRB-
cord-291727-4wfhuvww	126	6	using	use	VBG
cord-291727-4wfhuvww	126	7	databases	database	NNS
cord-291727-4wfhuvww	126	8	that	that	WDT
cord-291727-4wfhuvww	126	9	interrogate	interrogate	VBP
cord-291727-4wfhuvww	126	10	the	the	DT
cord-291727-4wfhuvww	126	11	genome	genome	NN
cord-291727-4wfhuvww	126	12	for	for	IN
cord-291727-4wfhuvww	126	13	−1	−1	NNP
cord-291727-4wfhuvww	126	14	or	or	CC
cord-291727-4wfhuvww	126	15	+1	+1	HYPH
cord-291727-4wfhuvww	126	16	frameshift	frameshift	NN
cord-291727-4wfhuvww	126	17	motifs	motif	NNS
cord-291727-4wfhuvww	126	18	can	can	MD
cord-291727-4wfhuvww	126	19	give	give	VB
cord-291727-4wfhuvww	126	20	information	information	NN
cord-291727-4wfhuvww	126	21	about	about	IN
cord-291727-4wfhuvww	126	22	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	126	23	events	event	NNS
cord-291727-4wfhuvww	126	24	.	.	.
cord-291727-4wfhuvww	127	1	Limitations	limitation	NNS
cord-291727-4wfhuvww	127	2	of	of	IN
cord-291727-4wfhuvww	127	3	this	this	DT
cord-291727-4wfhuvww	127	4	approach	approach	NN
cord-291727-4wfhuvww	127	5	are	be	VBP
cord-291727-4wfhuvww	127	6	that	that	IN
cord-291727-4wfhuvww	127	7	only	only	RB
cord-291727-4wfhuvww	127	8	known	know	VBN
cord-291727-4wfhuvww	127	9	frameshift	frameshift	NN
cord-291727-4wfhuvww	127	10	motifs	motif	NNS
cord-291727-4wfhuvww	127	11	are	be	VBP
cord-291727-4wfhuvww	127	12	taken	take	VBN
cord-291727-4wfhuvww	127	13	into	into	IN
cord-291727-4wfhuvww	127	14	account	account	NN
cord-291727-4wfhuvww	127	15	.	.	.
cord-291727-4wfhuvww	128	1	Furthermore	furthermore	RB
cord-291727-4wfhuvww	128	2	,	,	,
cord-291727-4wfhuvww	128	3	this	this	DT
cord-291727-4wfhuvww	128	4	method	method	NN
cord-291727-4wfhuvww	128	5	does	do	VBZ
cord-291727-4wfhuvww	128	6	not	not	RB
cord-291727-4wfhuvww	128	7	give	give	VB
cord-291727-4wfhuvww	128	8	any	any	DT
cord-291727-4wfhuvww	128	9	information	information	NN
cord-291727-4wfhuvww	128	10	whether	whether	IN
cord-291727-4wfhuvww	128	11	predicted	predict	VBD
cord-291727-4wfhuvww	128	12	frameshift	frameshift	NN
cord-291727-4wfhuvww	128	13	events	event	NNS
cord-291727-4wfhuvww	128	14	occur	occur	VBP
cord-291727-4wfhuvww	128	15	in	in	IN
cord-291727-4wfhuvww	128	16	vivo	vivo	NN
cord-291727-4wfhuvww	128	17	or	or	CC
cord-291727-4wfhuvww	128	18	the	the	DT
cord-291727-4wfhuvww	128	19	functional	functional	JJ
cord-291727-4wfhuvww	128	20	relevance	relevance	NN
cord-291727-4wfhuvww	128	21	of	of	IN
cord-291727-4wfhuvww	128	22	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	128	23	events	event	NNS
cord-291727-4wfhuvww	128	24	.	.	.
cord-291727-4wfhuvww	129	1	Experimental	experimental	JJ
cord-291727-4wfhuvww	129	2	methods	method	NNS
cord-291727-4wfhuvww	129	3	(	(	-LRB-
cord-291727-4wfhuvww	129	4	2	2	LS
cord-291727-4wfhuvww	129	5	)	)	-RRB-
cord-291727-4wfhuvww	129	6	can	can	MD
cord-291727-4wfhuvww	129	7	identify	identify	VB
cord-291727-4wfhuvww	129	8	frameshift	frameshift	NN
cord-291727-4wfhuvww	129	9	events	event	NNS
cord-291727-4wfhuvww	129	10	that	that	WDT
cord-291727-4wfhuvww	129	11	occur	occur	VBP
cord-291727-4wfhuvww	129	12	in	in	IN
cord-291727-4wfhuvww	129	13	vivo	vivo	NN
cord-291727-4wfhuvww	129	14	.	.	.
cord-291727-4wfhuvww	130	1	Most	most	RBS
cord-291727-4wfhuvww	130	2	commonly	commonly	RB
cord-291727-4wfhuvww	130	3	,	,	,
cord-291727-4wfhuvww	130	4	an	an	DT
cord-291727-4wfhuvww	130	5	antibody	antibody	NN
cord-291727-4wfhuvww	130	6	that	that	WDT
cord-291727-4wfhuvww	130	7	is	be	VBZ
cord-291727-4wfhuvww	130	8	specific	specific	JJ
cord-291727-4wfhuvww	130	9	to	to	IN
cord-291727-4wfhuvww	130	10	the	the	DT
cord-291727-4wfhuvww	130	11	out	out	JJ
cord-291727-4wfhuvww	130	12	-	-	HYPH
cord-291727-4wfhuvww	130	13	of	of	IN
cord-291727-4wfhuvww	130	14	-	-	HYPH
cord-291727-4wfhuvww	130	15	frame	frame	NN
cord-291727-4wfhuvww	130	16	sequence	sequence	NN
cord-291727-4wfhuvww	130	17	of	of	IN
cord-291727-4wfhuvww	130	18	the	the	DT
cord-291727-4wfhuvww	130	19	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	130	20	protein	protein	NN
cord-291727-4wfhuvww	130	21	is	be	VBZ
cord-291727-4wfhuvww	130	22	used	use	VBN
cord-291727-4wfhuvww	130	23	to	to	TO
cord-291727-4wfhuvww	130	24	detect	detect	VB
cord-291727-4wfhuvww	130	25	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	130	26	proteins	protein	NNS
cord-291727-4wfhuvww	130	27	.	.	.
cord-291727-4wfhuvww	131	1	Ribosome	ribosome	NN
cord-291727-4wfhuvww	131	2	profiling	profiling	NN
cord-291727-4wfhuvww	131	3	methods	method	NNS
cord-291727-4wfhuvww	131	4	such	such	JJ
cord-291727-4wfhuvww	131	5	as	as	IN
cord-291727-4wfhuvww	131	6	Ribo	Ribo	NNP
cord-291727-4wfhuvww	131	7	-	-	HYPH
cord-291727-4wfhuvww	131	8	Seq	Seq	NNP
cord-291727-4wfhuvww	131	9	(	(	-LRB-
cord-291727-4wfhuvww	131	10	3	3	CD
cord-291727-4wfhuvww	131	11	)	)	-RRB-
cord-291727-4wfhuvww	131	12	can	can	MD
cord-291727-4wfhuvww	131	13	be	be	VB
cord-291727-4wfhuvww	131	14	used	use	VBN
cord-291727-4wfhuvww	131	15	to	to	TO
cord-291727-4wfhuvww	131	16	detect	detect	VB
cord-291727-4wfhuvww	131	17	out	out	RP
cord-291727-4wfhuvww	131	18	-	-	HYPH
cord-291727-4wfhuvww	131	19	of	of	IN
cord-291727-4wfhuvww	131	20	-	-	HYPH
cord-291727-4wfhuvww	131	21	frame	frame	NN
cord-291727-4wfhuvww	131	22	peptides	peptide	NNS
cord-291727-4wfhuvww	131	23	on	on	IN
cord-291727-4wfhuvww	131	24	a	a	DT
cord-291727-4wfhuvww	131	25	genomic	genomic	JJ
cord-291727-4wfhuvww	131	26	scale	scale	NN
cord-291727-4wfhuvww	131	27	.	.	.
cord-291727-4wfhuvww	131	28	cDNA	cdna	NN
cord-291727-4wfhuvww	131	29	screening	screening	NN
cord-291727-4wfhuvww	131	30	and	and	CC
cord-291727-4wfhuvww	131	31	the	the	DT
cord-291727-4wfhuvww	131	32	use	use	NN
cord-291727-4wfhuvww	131	33	of	of	IN
cord-291727-4wfhuvww	131	34	tandem	tandem	JJ
cord-291727-4wfhuvww	131	35	luciferase	luciferase	NN
cord-291727-4wfhuvww	131	36	reporter	reporter	NN
cord-291727-4wfhuvww	131	37	constructs	construct	NNS
cord-291727-4wfhuvww	131	38	(	(	-LRB-
cord-291727-4wfhuvww	131	39	4	4	LS
cord-291727-4wfhuvww	131	40	)	)	-RRB-
cord-291727-4wfhuvww	131	41	can	can	MD
cord-291727-4wfhuvww	131	42	be	be	VB
cord-291727-4wfhuvww	131	43	used	use	VBN
cord-291727-4wfhuvww	131	44	to	to	TO
cord-291727-4wfhuvww	131	45	experimentally	experimentally	RB
cord-291727-4wfhuvww	131	46	detect	detect	VB
cord-291727-4wfhuvww	131	47	frameshift	frameshift	NN
cord-291727-4wfhuvww	131	48	events	event	NNS
cord-291727-4wfhuvww	131	49	.	.	.
cord-291727-4wfhuvww	132	1	Limitations	limitation	NNS
cord-291727-4wfhuvww	132	2	of	of	IN
cord-291727-4wfhuvww	132	3	this	this	DT
cord-291727-4wfhuvww	132	4	approach	approach	NN
cord-291727-4wfhuvww	132	5	are	be	VBP
cord-291727-4wfhuvww	132	6	that	that	IN
cord-291727-4wfhuvww	132	7	overexpression	overexpression	NN
cord-291727-4wfhuvww	132	8	may	may	MD
cord-291727-4wfhuvww	132	9	result	result	VB
cord-291727-4wfhuvww	132	10	in	in	IN
cord-291727-4wfhuvww	132	11	dysregulated	dysregulated	JJ
cord-291727-4wfhuvww	132	12	expression	expression	NN
cord-291727-4wfhuvww	132	13	and	and	CC
cord-291727-4wfhuvww	132	14	differences	difference	NNS
cord-291727-4wfhuvww	132	15	in	in	IN
cord-291727-4wfhuvww	132	16	translation	translation	NN
cord-291727-4wfhuvww	132	17	compared	compare	VBN
cord-291727-4wfhuvww	132	18	to	to	IN
cord-291727-4wfhuvww	132	19	endogenous	endogenous	JJ
cord-291727-4wfhuvww	132	20	expression	expression	NN
cord-291727-4wfhuvww	132	21	levels	level	NNS
cord-291727-4wfhuvww	132	22	.	.	.
cord-291727-4wfhuvww	133	1	Proteomic	proteomic	JJ
cord-291727-4wfhuvww	133	2	methods	method	NNS
cord-291727-4wfhuvww	133	3	(	(	-LRB-
cord-291727-4wfhuvww	133	4	5	5	LS
cord-291727-4wfhuvww	133	5	)	)	-RRB-
cord-291727-4wfhuvww	133	6	using	use	VBG
cord-291727-4wfhuvww	133	7	mass	mass	NN
cord-291727-4wfhuvww	133	8	spectrometry	spectrometry	NN
cord-291727-4wfhuvww	133	9	are	be	VBP
cord-291727-4wfhuvww	133	10	suitable	suitable	JJ
cord-291727-4wfhuvww	133	11	to	to	TO
cord-291727-4wfhuvww	133	12	detect	detect	VB
cord-291727-4wfhuvww	133	13	endogenous	endogenous	JJ
cord-291727-4wfhuvww	133	14	out	out	RB
cord-291727-4wfhuvww	133	15	-	-	HYPH
cord-291727-4wfhuvww	133	16	of	of	IN
cord-291727-4wfhuvww	133	17	-	-	HYPH
cord-291727-4wfhuvww	133	18	frame	frame	NN
cord-291727-4wfhuvww	133	19	peptides	peptide	NNS
cord-291727-4wfhuvww	133	20	.	.	.
cord-291727-4wfhuvww	134	1	However	however	RB
cord-291727-4wfhuvww	134	2	,	,	,
cord-291727-4wfhuvww	134	3	the	the	DT
cord-291727-4wfhuvww	134	4	levels	level	NNS
cord-291727-4wfhuvww	134	5	of	of	IN
cord-291727-4wfhuvww	134	6	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	134	7	proteins	protein	NNS
cord-291727-4wfhuvww	134	8	may	may	MD
cord-291727-4wfhuvww	134	9	be	be	VB
cord-291727-4wfhuvww	134	10	low	low	JJ
cord-291727-4wfhuvww	134	11	and	and	CC
cord-291727-4wfhuvww	134	12	escape	escape	VB
cord-291727-4wfhuvww	134	13	the	the	DT
cord-291727-4wfhuvww	134	14	detection	detection	NN
cord-291727-4wfhuvww	134	15	limit	limit	NN
cord-291727-4wfhuvww	134	16	.	.	.
cord-291727-4wfhuvww	135	1	A	a	DT
cord-291727-4wfhuvww	135	2	combination	combination	NN
cord-291727-4wfhuvww	135	3	of	of	IN
cord-291727-4wfhuvww	135	4	these	these	DT
cord-291727-4wfhuvww	135	5	methods	method	NNS
cord-291727-4wfhuvww	135	6	may	may	MD
cord-291727-4wfhuvww	135	7	provide	provide	VB
cord-291727-4wfhuvww	135	8	most	most	RBS
cord-291727-4wfhuvww	135	9	suitable	suitable	JJ
cord-291727-4wfhuvww	135	10	to	to	TO
cord-291727-4wfhuvww	135	11	identify	identify	VB
cord-291727-4wfhuvww	135	12	out	out	RP
cord-291727-4wfhuvww	135	13	-	-	HYPH
cord-291727-4wfhuvww	135	14	of	of	IN
cord-291727-4wfhuvww	135	15	-	-	HYPH
cord-291727-4wfhuvww	135	16	frame	frame	NN
cord-291727-4wfhuvww	135	17	proteins	protein	NNS
cord-291727-4wfhuvww	135	18	on	on	IN
cord-291727-4wfhuvww	135	19	a	a	DT
cord-291727-4wfhuvww	135	20	genome	genome	NN
cord-291727-4wfhuvww	135	21	-	-	HYPH
cord-291727-4wfhuvww	135	22	wide	wide	JJ
cord-291727-4wfhuvww	135	23	scale	scale	NN
cord-291727-4wfhuvww	135	24	.	.	.
cord-291727-4wfhuvww	136	1	See	see	VB
cord-291727-4wfhuvww	136	2	text	text	NN
cord-291727-4wfhuvww	136	3	for	for	IN
cord-291727-4wfhuvww	136	4	details	detail	NNS
cord-291727-4wfhuvww	136	5	.	.	.
cord-291727-4wfhuvww	137	1	structures	structure	NNS
cord-291727-4wfhuvww	137	2	(	(	-LRB-
cord-291727-4wfhuvww	137	3	Hammell	Hammell	NNP
cord-291727-4wfhuvww	137	4	et	et	FW
cord-291727-4wfhuvww	137	5	al	al	NNP
cord-291727-4wfhuvww	137	6	.	.	NNP
cord-291727-4wfhuvww	137	7	,	,	,
cord-291727-4wfhuvww	137	8	1999	1999	CD
cord-291727-4wfhuvww	137	9	)	)	-RRB-
cord-291727-4wfhuvww	137	10	.	.	.
cord-291727-4wfhuvww	138	1	This	this	DT
cord-291727-4wfhuvww	138	2	approach	approach	NN
cord-291727-4wfhuvww	138	3	identified	identify	VBD
cord-291727-4wfhuvww	138	4	over	over	IN
cord-291727-4wfhuvww	138	5	200	200	CD
cord-291727-4wfhuvww	138	6	putative	putative	JJ
cord-291727-4wfhuvww	138	7	programmed	program	VBN
cord-291727-4wfhuvww	138	8	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	138	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	138	10	events	event	NNS
cord-291727-4wfhuvww	138	11	.	.	.
cord-291727-4wfhuvww	139	1	For	for	IN
cord-291727-4wfhuvww	139	2	identification	identification	NN
cord-291727-4wfhuvww	139	3	of	of	IN
cord-291727-4wfhuvww	139	4	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	139	5	and	and	CC
cord-291727-4wfhuvww	139	6	slippery	slippery	JJ
cord-291727-4wfhuvww	139	7	sequences	sequence	NNS
cord-291727-4wfhuvww	139	8	in	in	IN
cord-291727-4wfhuvww	139	9	the	the	DT
cord-291727-4wfhuvww	139	10	genome	genome	NN
cord-291727-4wfhuvww	139	11	databases	database	NNS
cord-291727-4wfhuvww	139	12	such	such	JJ
cord-291727-4wfhuvww	139	13	as	as	IN
cord-291727-4wfhuvww	139	14	RECODE	RECODE	NNP
cord-291727-4wfhuvww	139	15	,	,	,
cord-291727-4wfhuvww	139	16	KnotInFrame	KnotInFrame	NNP
cord-291727-4wfhuvww	139	17	,	,	,
cord-291727-4wfhuvww	139	18	PRFdb	PRFdb	NNP
cord-291727-4wfhuvww	139	19	,	,	,
cord-291727-4wfhuvww	139	20	and	and	CC
cord-291727-4wfhuvww	139	21	FSdB	fsdb	NN
cord-291727-4wfhuvww	139	22	are	be	VBP
cord-291727-4wfhuvww	139	23	very	very	RB
cord-291727-4wfhuvww	139	24	useful	useful	JJ
cord-291727-4wfhuvww	139	25	(	(	-LRB-
cord-291727-4wfhuvww	139	26	Table	table	NN
cord-291727-4wfhuvww	139	27	1	1	CD
cord-291727-4wfhuvww	139	28	)	)	-RRB-
cord-291727-4wfhuvww	139	29	.	.	.
cord-291727-4wfhuvww	140	1	RECODE	RECODE	NNP
cord-291727-4wfhuvww	140	2	provides	provide	VBZ
cord-291727-4wfhuvww	140	3	information	information	NN
cord-291727-4wfhuvww	140	4	about	about	IN
cord-291727-4wfhuvww	140	5	programmed	program	VBN
cord-291727-4wfhuvww	140	6	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	140	7	,	,	,
cord-291727-4wfhuvww	140	8	read	read	VB
cord-291727-4wfhuvww	140	9	-	-	HYPH
cord-291727-4wfhuvww	140	10	through	through	NN
cord-291727-4wfhuvww	140	11	and	and	CC
cord-291727-4wfhuvww	140	12	bypassing	bypass	VBG
cord-291727-4wfhuvww	140	13	,	,	,
cord-291727-4wfhuvww	140	14	based	base	VBN
cord-291727-4wfhuvww	140	15	on	on	IN
cord-291727-4wfhuvww	140	16	published	publish	VBN
cord-291727-4wfhuvww	140	17	results	result	NNS
cord-291727-4wfhuvww	140	18	in	in	IN
cord-291727-4wfhuvww	140	19	the	the	DT
cord-291727-4wfhuvww	140	20	literature	literature	NN
cord-291727-4wfhuvww	141	1	(	(	-LRB-
cord-291727-4wfhuvww	141	2	Baranov	Baranov	NNP
cord-291727-4wfhuvww	141	3	et	et	NNP
cord-291727-4wfhuvww	141	4	al	al	NNP
cord-291727-4wfhuvww	141	5	.	.	NNP
cord-291727-4wfhuvww	141	6	,	,	,
cord-291727-4wfhuvww	141	7	2001	2001	CD
cord-291727-4wfhuvww	141	8	;	;	:
cord-291727-4wfhuvww	141	9	Bekaert	Bekaert	NNP
cord-291727-4wfhuvww	141	10	et	et	NNP
cord-291727-4wfhuvww	141	11	al	al	NNP
cord-291727-4wfhuvww	141	12	.	.	NNP
cord-291727-4wfhuvww	141	13	,	,	,
cord-291727-4wfhuvww	141	14	2010	2010	CD
cord-291727-4wfhuvww	141	15	)	)	-RRB-
cord-291727-4wfhuvww	141	16	.	.	.
cord-291727-4wfhuvww	142	1	The	the	DT
cord-291727-4wfhuvww	142	2	database	database	NN
cord-291727-4wfhuvww	142	3	utilizes	utilize	VBZ
cord-291727-4wfhuvww	142	4	information	information	NN
cord-291727-4wfhuvww	142	5	from	from	IN
cord-291727-4wfhuvww	142	6	∼1500	∼1500	VBG
cord-291727-4wfhuvww	142	7	known	know	VBN
cord-291727-4wfhuvww	142	8	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	142	9	gene	gene	NN
cord-291727-4wfhuvww	142	10	products	product	NNS
cord-291727-4wfhuvww	142	11	.	.	.
cord-291727-4wfhuvww	143	1	A	a	DT
cord-291727-4wfhuvww	143	2	majority	majority	NN
cord-291727-4wfhuvww	143	3	of	of	IN
cord-291727-4wfhuvww	143	4	the	the	DT
cord-291727-4wfhuvww	143	5	data	datum	NNS
cord-291727-4wfhuvww	143	6	on	on	IN
cord-291727-4wfhuvww	143	7	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	143	8	comes	come	VBZ
cord-291727-4wfhuvww	143	9	from	from	IN
cord-291727-4wfhuvww	143	10	two	two	CD
cord-291727-4wfhuvww	143	11	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	143	12	proteins	protein	NNS
cord-291727-4wfhuvww	143	13	,	,	,
cord-291727-4wfhuvww	143	14	RF2	RF2	NNP
cord-291727-4wfhuvww	143	15	and	and	CC
cord-291727-4wfhuvww	143	16	antizyme	antizyme	NNS
cord-291727-4wfhuvww	143	17	,	,	,
cord-291727-4wfhuvww	143	18	and	and	CC
cord-291727-4wfhuvww	143	19	is	be	VBZ
cord-291727-4wfhuvww	143	20	constantly	constantly	RB
cord-291727-4wfhuvww	143	21	updated	update	VBN
cord-291727-4wfhuvww	143	22	using	use	VBG
cord-291727-4wfhuvww	143	23	the	the	DT
cord-291727-4wfhuvww	143	24	respective	respective	JJ
cord-291727-4wfhuvww	143	25	prediction	prediction	NN
cord-291727-4wfhuvww	143	26	tools	tool	NNS
cord-291727-4wfhuvww	143	27	[	[	-LRB-
cord-291727-4wfhuvww	143	28	ARFA	ARFA	NNP
cord-291727-4wfhuvww	143	29	(	(	-LRB-
cord-291727-4wfhuvww	143	30	Bekaert	Bekaert	NNP
cord-291727-4wfhuvww	143	31	et	et	NNP
cord-291727-4wfhuvww	143	32	al	al	NNP
cord-291727-4wfhuvww	143	33	.	.	NNP
cord-291727-4wfhuvww	143	34	,	,	,
cord-291727-4wfhuvww	143	35	2006	2006	CD
cord-291727-4wfhuvww	143	36	)	)	-RRB-
cord-291727-4wfhuvww	143	37	and	and	CC
cord-291727-4wfhuvww	143	38	OAF	OAF	NNP
cord-291727-4wfhuvww	143	39	(	(	-LRB-
cord-291727-4wfhuvww	143	40	Bekaert	Bekaert	NNP
cord-291727-4wfhuvww	143	41	et	et	NNP
cord-291727-4wfhuvww	143	42	al	al	NNP
cord-291727-4wfhuvww	143	43	.	.	NNP
cord-291727-4wfhuvww	143	44	,	,	,
cord-291727-4wfhuvww	143	45	2008	2008	CD
cord-291727-4wfhuvww	143	46	)	)	-RRB-
cord-291727-4wfhuvww	143	47	,	,	,
cord-291727-4wfhuvww	143	48	respectively	respectively	RB
cord-291727-4wfhuvww	143	49	]	]	-RRB-
cord-291727-4wfhuvww	143	50	.	.	.
cord-291727-4wfhuvww	144	1	PseudoViewer	PseudoViewer	NNP
cord-291727-4wfhuvww	144	2	is	be	VBZ
cord-291727-4wfhuvww	144	3	used	use	VBN
cord-291727-4wfhuvww	144	4	for	for	IN
cord-291727-4wfhuvww	144	5	visualization	visualization	NN
cord-291727-4wfhuvww	144	6	of	of	IN
cord-291727-4wfhuvww	144	7	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	144	8	structures	structure	NNS
cord-291727-4wfhuvww	144	9	.	.	.
cord-291727-4wfhuvww	145	1	(	(	-LRB-
cord-291727-4wfhuvww	145	2	http://recode.ucc.ie	http://recode.ucc.ie	NNP
cord-291727-4wfhuvww	145	3	)	)	-RRB-
cord-291727-4wfhuvww	145	4	KnotInFrame	KnotInFrame	NNP
cord-291727-4wfhuvww	145	5	is	be	VBZ
cord-291727-4wfhuvww	145	6	a	a	DT
cord-291727-4wfhuvww	145	7	program	program	NN
cord-291727-4wfhuvww	145	8	for	for	IN
cord-291727-4wfhuvww	145	9	predicting	predict	VBG
cord-291727-4wfhuvww	145	10	sites	site	NNS
cord-291727-4wfhuvww	145	11	of	of	IN
cord-291727-4wfhuvww	145	12	−1	−1	NNP
cord-291727-4wfhuvww	145	13	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	145	14	based	base	VBN
cord-291727-4wfhuvww	145	15	on	on	IN
cord-291727-4wfhuvww	145	16	the	the	DT
cord-291727-4wfhuvww	145	17	formation	formation	NN
cord-291727-4wfhuvww	145	18	of	of	IN
cord-291727-4wfhuvww	145	19	RNA	RNA	NNP
cord-291727-4wfhuvww	145	20	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	145	21	(	(	-LRB-
cord-291727-4wfhuvww	145	22	Theis	Theis	NNP
cord-291727-4wfhuvww	145	23	et	et	FW
cord-291727-4wfhuvww	145	24	al	al	NNP
cord-291727-4wfhuvww	145	25	.	.	NNP
cord-291727-4wfhuvww	145	26	,	,	,
cord-291727-4wfhuvww	145	27	2008	2008	CD
cord-291727-4wfhuvww	145	28	)	)	-RRB-
cord-291727-4wfhuvww	145	29	.	.	.
cord-291727-4wfhuvww	146	1	The	the	DT
cord-291727-4wfhuvww	146	2	authors	author	NNS
cord-291727-4wfhuvww	146	3	have	have	VBP
cord-291727-4wfhuvww	146	4	developed	develop	VBN
cord-291727-4wfhuvww	146	5	a	a	DT
cord-291727-4wfhuvww	146	6	specialized	specialized	JJ
cord-291727-4wfhuvww	146	7	RNAfolding	rnafolde	VBG
cord-291727-4wfhuvww	146	8	program	program	NN
cord-291727-4wfhuvww	146	9	called	call	VBN
cord-291727-4wfhuvww	146	10	pknotsRG	pknotsRG	NNP
cord-291727-4wfhuvww	146	11	-	-	HYPH
cord-291727-4wfhuvww	146	12	fs	fs	NNP
cord-291727-4wfhuvww	146	13	that	that	WDT
cord-291727-4wfhuvww	146	14	compares	compare	VBZ
cord-291727-4wfhuvww	146	15	the	the	DT
cord-291727-4wfhuvww	146	16	minimal	minimal	JJ
cord-291727-4wfhuvww	146	17	free	free	JJ
cord-291727-4wfhuvww	146	18	energy	energy	NN
cord-291727-4wfhuvww	146	19	of	of	IN
cord-291727-4wfhuvww	146	20	an	an	DT
cord-291727-4wfhuvww	146	21	enforced	enforce	VBN
cord-291727-4wfhuvww	146	22	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	146	23	structure	structure	NN
cord-291727-4wfhuvww	146	24	to	to	IN
cord-291727-4wfhuvww	146	25	that	that	DT
cord-291727-4wfhuvww	146	26	of	of	IN
cord-291727-4wfhuvww	146	27	a	a	DT
cord-291727-4wfhuvww	146	28	freely	freely	RB
cord-291727-4wfhuvww	146	29	folded	fold	VBN
cord-291727-4wfhuvww	146	30	structure	structure	NN
cord-291727-4wfhuvww	146	31	such	such	JJ
cord-291727-4wfhuvww	146	32	as	as	IN
cord-291727-4wfhuvww	146	33	that	that	DT
cord-291727-4wfhuvww	146	34	given	give	VBN
cord-291727-4wfhuvww	146	35	by	by	IN
cord-291727-4wfhuvww	146	36	RNAfold	RNAfold	NNP
cord-291727-4wfhuvww	146	37	.	.	.
cord-291727-4wfhuvww	147	1	The	the	DT
cord-291727-4wfhuvww	147	2	spacer	spacer	NN
cord-291727-4wfhuvww	147	3	region	region	NN
cord-291727-4wfhuvww	147	4	after	after	IN
cord-291727-4wfhuvww	147	5	the	the	DT
cord-291727-4wfhuvww	147	6	common	common	JJ
cord-291727-4wfhuvww	147	7	slippery	slippery	JJ
cord-291727-4wfhuvww	147	8	sequence	sequence	NN
cord-291727-4wfhuvww	147	9	X	x	NN
cord-291727-4wfhuvww	147	10	XXY	XXY	NNP
cord-291727-4wfhuvww	147	11	YYZ	YYZ	NNP
cord-291727-4wfhuvww	147	12	is	be	VBZ
cord-291727-4wfhuvww	147	13	between	between	IN
cord-291727-4wfhuvww	147	14	1	1	CD
cord-291727-4wfhuvww	147	15	and	and	CC
cord-291727-4wfhuvww	147	16	12	12	CD
cord-291727-4wfhuvww	147	17	nt	nt	RB
cord-291727-4wfhuvww	147	18	long	long	RB
cord-291727-4wfhuvww	147	19	.	.	.
cord-291727-4wfhuvww	148	1	(	(	-LRB-
cord-291727-4wfhuvww	148	2	http://bibiserv.techfak.uni-bielefeld.de/knotinframe	http://bibiserv.techfak.uni-bielefeld.de/knotinframe	NNP
cord-291727-4wfhuvww	148	3	)	)	-RRB-
cord-291727-4wfhuvww	148	4	PRFdb	PRFdb	NNP
cord-291727-4wfhuvww	148	5	(	(	-LRB-
cord-291727-4wfhuvww	148	6	http://prfdb	http://prfdb	NNP
cord-291727-4wfhuvww	148	7	/	/	SYM
cord-291727-4wfhuvww	148	8	umd.edu/	umd.edu/	NNP
cord-291727-4wfhuvww	148	9	)	)	-RRB-
cord-291727-4wfhuvww	148	10	is	be	VBZ
cord-291727-4wfhuvww	148	11	limited	limit	VBN
cord-291727-4wfhuvww	148	12	to	to	IN
cord-291727-4wfhuvww	148	13	−1	−1	NNP
cord-291727-4wfhuvww	148	14	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	148	15	in	in	IN
cord-291727-4wfhuvww	148	16	eukaryotes	eukaryote	NNS
cord-291727-4wfhuvww	148	17	only	only	RB
cord-291727-4wfhuvww	148	18	.	.	.
cord-291727-4wfhuvww	149	1	Again	again	RB
cord-291727-4wfhuvww	149	2	,	,	,
cord-291727-4wfhuvww	149	3	the	the	DT
cord-291727-4wfhuvww	149	4	prediction	prediction	NN
cord-291727-4wfhuvww	149	5	if	if	IN
cord-291727-4wfhuvww	149	6	based	base	VBN
cord-291727-4wfhuvww	149	7	on	on	IN
cord-291727-4wfhuvww	149	8	the	the	DT
cord-291727-4wfhuvww	149	9	presence	presence	NN
cord-291727-4wfhuvww	149	10	of	of	IN
cord-291727-4wfhuvww	149	11	a	a	DT
cord-291727-4wfhuvww	149	12	heptameric	heptameric	JJ
cord-291727-4wfhuvww	149	13	slippery	slippery	JJ
cord-291727-4wfhuvww	149	14	sequence	sequence	NN
cord-291727-4wfhuvww	149	15	in	in	IN
cord-291727-4wfhuvww	149	16	combination	combination	NN
cord-291727-4wfhuvww	149	17	with	with	IN
cord-291727-4wfhuvww	149	18	a	a	DT
cord-291727-4wfhuvww	149	19	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	149	20	(	(	-LRB-
cord-291727-4wfhuvww	149	21	Jacobs	Jacobs	NNP
cord-291727-4wfhuvww	149	22	et	et	NNP
cord-291727-4wfhuvww	149	23	al	al	NNP
cord-291727-4wfhuvww	149	24	.	.	NNP
cord-291727-4wfhuvww	149	25	,	,	,
cord-291727-4wfhuvww	149	26	2007	2007	CD
cord-291727-4wfhuvww	149	27	)	)	-RRB-
cord-291727-4wfhuvww	149	28	.	.	.
cord-291727-4wfhuvww	150	1	The	the	DT
cord-291727-4wfhuvww	150	2	slippery	slippery	JJ
cord-291727-4wfhuvww	150	3	sequence	sequence	NN
cord-291727-4wfhuvww	150	4	is	be	VBZ
cord-291727-4wfhuvww	150	5	modeled	model	VBN
cord-291727-4wfhuvww	150	6	with	with	IN
cord-291727-4wfhuvww	150	7	a	a	DT
cord-291727-4wfhuvww	150	8	1	1	CD
cord-291727-4wfhuvww	150	9	-	-	SYM
cord-291727-4wfhuvww	150	10	8	8	CD
cord-291727-4wfhuvww	150	11	nt	nt	RB
cord-291727-4wfhuvww	150	12	spacer	spacer	NN
cord-291727-4wfhuvww	150	13	,	,	,
cord-291727-4wfhuvww	150	14	and	and	CC
cord-291727-4wfhuvww	150	15	the	the	DT
cord-291727-4wfhuvww	150	16	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	150	17	is	be	VBZ
cord-291727-4wfhuvww	150	18	identified	identify	VBN
cord-291727-4wfhuvww	150	19	using	use	VBG
cord-291727-4wfhuvww	150	20	RNAMotif	rnamotif	NN
cord-291727-4wfhuvww	150	21	.	.	.
cord-291727-4wfhuvww	151	1	The	the	DT
cord-291727-4wfhuvww	151	2	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	151	3	is	be	VBZ
cord-291727-4wfhuvww	151	4	then	then	RB
cord-291727-4wfhuvww	151	5	further	further	RB
cord-291727-4wfhuvww	151	6	confirmed	confirm	VBN
cord-291727-4wfhuvww	151	7	with	with	IN
cord-291727-4wfhuvww	151	8	other	other	JJ
cord-291727-4wfhuvww	151	9	secondary	secondary	JJ
cord-291727-4wfhuvww	151	10	RNA	rna	NN
cord-291727-4wfhuvww	151	11	-	-	HYPH
cord-291727-4wfhuvww	151	12	structure	structure	NN
cord-291727-4wfhuvww	151	13	-	-	HYPH
cord-291727-4wfhuvww	151	14	prediction	prediction	NN
cord-291727-4wfhuvww	151	15	tools	tool	NNS
cord-291727-4wfhuvww	151	16	,	,	,
cord-291727-4wfhuvww	151	17	including	include	VBG
cord-291727-4wfhuvww	151	18	Pknots	Pknots	NNP
cord-291727-4wfhuvww	151	19	(	(	-LRB-
cord-291727-4wfhuvww	151	20	Rivas	Rivas	NNP
cord-291727-4wfhuvww	151	21	and	and	CC
cord-291727-4wfhuvww	151	22	Eddy	Eddy	NNP
cord-291727-4wfhuvww	151	23	,	,	,
cord-291727-4wfhuvww	151	24	1999	1999	CD
cord-291727-4wfhuvww	151	25	)	)	-RRB-
cord-291727-4wfhuvww	151	26	,	,	,
cord-291727-4wfhuvww	151	27	Nupack	Nupack	NNP
cord-291727-4wfhuvww	151	28	(	(	-LRB-
cord-291727-4wfhuvww	151	29	Dirks	Dirks	NNP
cord-291727-4wfhuvww	151	30	and	and	CC
cord-291727-4wfhuvww	151	31	Pierce	Pierce	NNP
cord-291727-4wfhuvww	151	32	,	,	,
cord-291727-4wfhuvww	151	33	2004	2004	CD
cord-291727-4wfhuvww	151	34	)	)	-RRB-
cord-291727-4wfhuvww	151	35	,	,	,
cord-291727-4wfhuvww	151	36	and	and	CC
cord-291727-4wfhuvww	151	37	HotKnots	HotKnots	NNP
cord-291727-4wfhuvww	151	38	(	(	-LRB-
cord-291727-4wfhuvww	151	39	Ren	Ren	NNP
cord-291727-4wfhuvww	151	40	et	et	NNP
cord-291727-4wfhuvww	151	41	al	al	NNP
cord-291727-4wfhuvww	151	42	.	.	NNP
cord-291727-4wfhuvww	151	43	,	,	,
cord-291727-4wfhuvww	151	44	2005	2005	CD
cord-291727-4wfhuvww	151	45	)	)	-RRB-
cord-291727-4wfhuvww	151	46	.	.	.
cord-291727-4wfhuvww	152	1	The	the	DT
cord-291727-4wfhuvww	152	2	Frameshift	Frameshift	NNP
cord-291727-4wfhuvww	152	3	Signal	Signal	NNP
cord-291727-4wfhuvww	152	4	Database	Database	NNP
cord-291727-4wfhuvww	152	5	(	(	-LRB-
cord-291727-4wfhuvww	152	6	FSDB	FSDB	NNP
cord-291727-4wfhuvww	152	7	)	)	-RRB-
cord-291727-4wfhuvww	152	8	is	be	VBZ
cord-291727-4wfhuvww	152	9	a	a	DT
cord-291727-4wfhuvww	152	10	compilation	compilation	NN
cord-291727-4wfhuvww	152	11	of	of	IN
cord-291727-4wfhuvww	152	12	all	all	DT
cord-291727-4wfhuvww	152	13	known	know	VBN
cord-291727-4wfhuvww	152	14	frameshift	frameshift	NN
cord-291727-4wfhuvww	152	15	motifs	motif	NNS
cord-291727-4wfhuvww	152	16	,	,	,
cord-291727-4wfhuvww	152	17	plus	plus	CC
cord-291727-4wfhuvww	152	18	some	some	DT
cord-291727-4wfhuvww	152	19	reported	report	VBD
cord-291727-4wfhuvww	152	20	(	(	-LRB-
cord-291727-4wfhuvww	152	21	predicted	predict	VBN
cord-291727-4wfhuvww	152	22	)	)	-RRB-
cord-291727-4wfhuvww	153	1	frameshift	frameshift	NN
cord-291727-4wfhuvww	153	2	sequences	sequence	NNS
cord-291727-4wfhuvww	154	1	(	(	-LRB-
cord-291727-4wfhuvww	154	2	Moon	Moon	NNP
cord-291727-4wfhuvww	154	3	et	et	NNP
cord-291727-4wfhuvww	154	4	al	al	NNP
cord-291727-4wfhuvww	154	5	.	.	NNP
cord-291727-4wfhuvww	154	6	,	,	,
cord-291727-4wfhuvww	154	7	2007	2007	CD
cord-291727-4wfhuvww	154	8	)	)	-RRB-
cord-291727-4wfhuvww	154	9	.	.	.
cord-291727-4wfhuvww	155	1	Based	base	VBN
cord-291727-4wfhuvww	155	2	on	on	IN
cord-291727-4wfhuvww	155	3	commonalities	commonality	NNS
cord-291727-4wfhuvww	155	4	between	between	IN
cord-291727-4wfhuvww	155	5	these	these	DT
cord-291727-4wfhuvww	155	6	sequences	sequence	NNS
cord-291727-4wfhuvww	155	7	,	,	,
cord-291727-4wfhuvww	155	8	the	the	DT
cord-291727-4wfhuvww	155	9	associated	associate	VBN
cord-291727-4wfhuvww	155	10	FSFinder	FSFinder	NNP
cord-291727-4wfhuvww	155	11	allows	allow	VBZ
cord-291727-4wfhuvww	155	12	mining	mining	NN
cord-291727-4wfhuvww	155	13	of	of	IN
cord-291727-4wfhuvww	155	14	the	the	DT
cord-291727-4wfhuvww	155	15	genome	genome	NN
cord-291727-4wfhuvww	155	16	for	for	IN
cord-291727-4wfhuvww	155	17	potential	potential	JJ
cord-291727-4wfhuvww	155	18	frameshift	frameshift	NN
cord-291727-4wfhuvww	155	19	sequences	sequence	NNS
cord-291727-4wfhuvww	155	20	.	.	.
cord-291727-4wfhuvww	156	1	(	(	-LRB-
cord-291727-4wfhuvww	156	2	http://	http://	NNP
cord-291727-4wfhuvww	156	3	wilab.inha.ac.kr/fsdb	wilab.inha.ac.kr/fsdb	NNP
cord-291727-4wfhuvww	156	4	)	)	-RRB-
cord-291727-4wfhuvww	157	1	At	at	IN
cord-291727-4wfhuvww	157	2	present	present	NN
cord-291727-4wfhuvww	157	3	,	,	,
cord-291727-4wfhuvww	157	4	the	the	DT
cord-291727-4wfhuvww	157	5	database	database	NN
cord-291727-4wfhuvww	157	6	contains	contain	VBZ
cord-291727-4wfhuvww	157	7	a	a	DT
cord-291727-4wfhuvww	157	8	total	total	NN
cord-291727-4wfhuvww	157	9	of	of	IN
cord-291727-4wfhuvww	157	10	63	63	CD
cord-291727-4wfhuvww	157	11	experimental	experimental	JJ
cord-291727-4wfhuvww	157	12	and	and	CC
cord-291727-4wfhuvww	157	13	190	190	CD
cord-291727-4wfhuvww	157	14	predicted	predict	VBN
cord-291727-4wfhuvww	157	15	sequences	sequence	NNS
cord-291727-4wfhuvww	157	16	from	from	IN
cord-291727-4wfhuvww	157	17	viruses	virus	NNS
cord-291727-4wfhuvww	157	18	,	,	,
cord-291727-4wfhuvww	157	19	prokaryotes	prokaryote	NNS
cord-291727-4wfhuvww	157	20	and	and	CC
cord-291727-4wfhuvww	157	21	eukaryotes	eukaryote	NNS
cord-291727-4wfhuvww	157	22	.	.	.
cord-291727-4wfhuvww	158	1	FSFinder	FSFinder	NNP
cord-291727-4wfhuvww	158	2	uses	use	VBZ
cord-291727-4wfhuvww	158	3	a	a	DT
cord-291727-4wfhuvww	158	4	combination	combination	NN
cord-291727-4wfhuvww	158	5	of	of	IN
cord-291727-4wfhuvww	158	6	slippery	slippery	JJ
cord-291727-4wfhuvww	158	7	sequences	sequence	NNS
cord-291727-4wfhuvww	158	8	and	and	CC
cord-291727-4wfhuvww	158	9	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	158	10	or	or	CC
cord-291727-4wfhuvww	158	11	stem	stem	NN
cord-291727-4wfhuvww	158	12	-	-	HYPH
cord-291727-4wfhuvww	158	13	loop	loop	NN
cord-291727-4wfhuvww	158	14	prediction	prediction	NN
cord-291727-4wfhuvww	158	15	.	.	.
cord-291727-4wfhuvww	159	1	The	the	DT
cord-291727-4wfhuvww	159	2	heptameric	heptameric	JJ
cord-291727-4wfhuvww	159	3	slippery	slippery	JJ
cord-291727-4wfhuvww	159	4	sequences	sequence	NNS
cord-291727-4wfhuvww	159	5	for	for	IN
cord-291727-4wfhuvww	159	6	+1	+1	HYPH
cord-291727-4wfhuvww	159	7	and	and	CC
cord-291727-4wfhuvww	159	8	−1	−1	NNP
cord-291727-4wfhuvww	159	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	159	10	are	be	VBP
cord-291727-4wfhuvww	159	11	Frontiers	Frontiers	NNPS
cord-291727-4wfhuvww	159	12	in	in	IN
cord-291727-4wfhuvww	159	13	Genetics	Genetics	NNP
cord-291727-4wfhuvww	159	14	|	|	NNP
cord-291727-4wfhuvww	159	15	Genomic	Genomic	NNP
cord-291727-4wfhuvww	159	16	Assay	Assay	NNP
cord-291727-4wfhuvww	159	17	Technology	Technology	NNP
cord-291727-4wfhuvww	160	1	November	November	NNP
cord-291727-4wfhuvww	160	2	2012	2012	CD
cord-291727-4wfhuvww	160	3	|	|	NNP
cord-291727-4wfhuvww	160	4	Volume	Volume	NNP
cord-291727-4wfhuvww	160	5	3	3	CD
cord-291727-4wfhuvww	160	6	|	|	NNP
cord-291727-4wfhuvww	160	7	Article	Article	NNP
cord-291727-4wfhuvww	160	8	242	242	CD
cord-291727-4wfhuvww	160	9	|	|	SYM
cord-291727-4wfhuvww	160	10	4	4	CD
cord-291727-4wfhuvww	160	11	listed	list	VBN
cord-291727-4wfhuvww	160	12	in	in	IN
cord-291727-4wfhuvww	160	13	Table	Table	NNP
cord-291727-4wfhuvww	160	14	2	2	CD
cord-291727-4wfhuvww	160	15	.	.	.
cord-291727-4wfhuvww	161	1	It	-PRON-	PRP
cord-291727-4wfhuvww	161	2	is	be	VBZ
cord-291727-4wfhuvww	161	3	noteworthy	noteworthy	JJ
cord-291727-4wfhuvww	161	4	that	that	IN
cord-291727-4wfhuvww	161	5	FSDB	FSDB	NNP
cord-291727-4wfhuvww	161	6	includes	include	VBZ
cord-291727-4wfhuvww	161	7	deviations	deviation	NNS
cord-291727-4wfhuvww	161	8	from	from	IN
cord-291727-4wfhuvww	161	9	the	the	DT
cord-291727-4wfhuvww	161	10	standard	standard	JJ
cord-291727-4wfhuvww	161	11	X	X	NNP
cord-291727-4wfhuvww	161	12	XXY	XXY	NNP
cord-291727-4wfhuvww	161	13	YYZ	YYZ	NNP
cord-291727-4wfhuvww	161	14	slippery	slippery	JJ
cord-291727-4wfhuvww	161	15	sequence	sequence	NN
cord-291727-4wfhuvww	161	16	for	for	IN
cord-291727-4wfhuvww	161	17	prediction	prediction	NN
cord-291727-4wfhuvww	161	18	of	of	IN
cord-291727-4wfhuvww	161	19	−1	−1	NNP
cord-291727-4wfhuvww	161	20	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	161	21	,	,	,
cord-291727-4wfhuvww	161	22	whereas	whereas	IN
cord-291727-4wfhuvww	161	23	+1	+1	HYPH
cord-291727-4wfhuvww	161	24	frameshift	frameshift	NN
cord-291727-4wfhuvww	161	25	sequences	sequence	NNS
cord-291727-4wfhuvww	161	26	often	often	RB
cord-291727-4wfhuvww	161	27	contain	contain	VBP
cord-291727-4wfhuvww	161	28	stop	stop	NN
cord-291727-4wfhuvww	161	29	codons	codon	NNS
cord-291727-4wfhuvww	161	30	.	.	.
cord-291727-4wfhuvww	162	1	Although	although	IN
cord-291727-4wfhuvww	162	2	most	most	JJS
cord-291727-4wfhuvww	162	3	prediction	prediction	NN
cord-291727-4wfhuvww	162	4	databases	database	NNS
cord-291727-4wfhuvww	162	5	use	use	VBP
cord-291727-4wfhuvww	162	6	similar	similar	JJ
cord-291727-4wfhuvww	162	7	principles	principle	NNS
cord-291727-4wfhuvww	162	8	(	(	-LRB-
cord-291727-4wfhuvww	162	9	slippery	slippery	JJ
cord-291727-4wfhuvww	162	10	sequence	sequence	NN
cord-291727-4wfhuvww	162	11	plus	plus	CC
cord-291727-4wfhuvww	162	12	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	162	13	)	)	-RRB-
cord-291727-4wfhuvww	162	14	,	,	,
cord-291727-4wfhuvww	162	15	they	-PRON-	PRP
cord-291727-4wfhuvww	162	16	differ	differ	VBP
cord-291727-4wfhuvww	162	17	in	in	IN
cord-291727-4wfhuvww	162	18	prediction	prediction	NN
cord-291727-4wfhuvww	162	19	of	of	IN
cord-291727-4wfhuvww	162	20	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	162	21	events	event	NNS
cord-291727-4wfhuvww	162	22	.	.	.
cord-291727-4wfhuvww	163	1	This	this	DT
cord-291727-4wfhuvww	163	2	may	may	MD
cord-291727-4wfhuvww	163	3	be	be	VB
cord-291727-4wfhuvww	163	4	due	due	JJ
cord-291727-4wfhuvww	163	5	to	to	IN
cord-291727-4wfhuvww	163	6	variable	variable	JJ
cord-291727-4wfhuvww	163	7	thresholds	threshold	NNS
cord-291727-4wfhuvww	163	8	applied	apply	VBN
cord-291727-4wfhuvww	163	9	or	or	CC
cord-291727-4wfhuvww	163	10	different	different	JJ
cord-291727-4wfhuvww	163	11	RNA	rna	NN
cord-291727-4wfhuvww	163	12	folding	fold	VBG
cord-291727-4wfhuvww	163	13	algorithms	algorithm	NNS
cord-291727-4wfhuvww	163	14	.	.	.
cord-291727-4wfhuvww	164	1	In	in	IN
cord-291727-4wfhuvww	164	2	order	order	NN
cord-291727-4wfhuvww	164	3	to	to	TO
cord-291727-4wfhuvww	164	4	identify	identify	VB
cord-291727-4wfhuvww	164	5	expressed	express	VBN
cord-291727-4wfhuvww	164	6	proteins	protein	NNS
cord-291727-4wfhuvww	164	7	,	,	,
cord-291727-4wfhuvww	164	8	one	one	PRP
cord-291727-4wfhuvww	164	9	has	have	VBZ
cord-291727-4wfhuvww	164	10	to	to	TO
cord-291727-4wfhuvww	164	11	consider	consider	VB
cord-291727-4wfhuvww	164	12	the	the	DT
cord-291727-4wfhuvww	164	13	length	length	NN
cord-291727-4wfhuvww	164	14	of	of	IN
cord-291727-4wfhuvww	164	15	the	the	DT
cord-291727-4wfhuvww	164	16	predicted	predict	VBN
cord-291727-4wfhuvww	164	17	out	out	NN
cord-291727-4wfhuvww	164	18	-	-	HYPH
cord-291727-4wfhuvww	164	19	of	of	IN
cord-291727-4wfhuvww	164	20	-	-	HYPH
cord-291727-4wfhuvww	164	21	frame	frame	NN
cord-291727-4wfhuvww	164	22	protein	protein	NN
cord-291727-4wfhuvww	164	23	.	.	.
cord-291727-4wfhuvww	165	1	Most	Most	JJS
cord-291727-4wfhuvww	165	2	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	165	3	proteins	protein	NNS
cord-291727-4wfhuvww	165	4	initiated	initiate	VBN
cord-291727-4wfhuvww	165	5	by	by	IN
cord-291727-4wfhuvww	165	6	predicted	predict	VBN
cord-291727-4wfhuvww	165	7	slippery	slippery	JJ
cord-291727-4wfhuvww	165	8	sites	site	NNS
cord-291727-4wfhuvww	165	9	will	will	MD
cord-291727-4wfhuvww	165	10	terminate	terminate	VB
cord-291727-4wfhuvww	165	11	within	within	IN
cord-291727-4wfhuvww	165	12	5	5	CD
cord-291727-4wfhuvww	165	13	-	-	SYM
cord-291727-4wfhuvww	165	14	10	10	CD
cord-291727-4wfhuvww	165	15	codons	codon	NNS
cord-291727-4wfhuvww	165	16	,	,	,
cord-291727-4wfhuvww	165	17	thus	thus	RB
cord-291727-4wfhuvww	165	18	producing	produce	VBG
cord-291727-4wfhuvww	165	19	truncated	truncated	JJ
cord-291727-4wfhuvww	165	20	or	or	CC
cord-291727-4wfhuvww	165	21	non	non	JJ
cord-291727-4wfhuvww	165	22	-	-	JJ
cord-291727-4wfhuvww	165	23	functional	functional	JJ
cord-291727-4wfhuvww	165	24	peptides	peptide	NNS
cord-291727-4wfhuvww	165	25	or	or	CC
cord-291727-4wfhuvww	165	26	proteins	protein	NNS
cord-291727-4wfhuvww	165	27	.	.	.
cord-291727-4wfhuvww	166	1	Alternative	alternative	JJ
cord-291727-4wfhuvww	166	2	approaches	approach	NNS
cord-291727-4wfhuvww	166	3	that	that	WDT
cord-291727-4wfhuvww	166	4	take	take	VBP
cord-291727-4wfhuvww	166	5	out	out	RB
cord-291727-4wfhuvww	166	6	-	-	HYPH
cord-291727-4wfhuvww	166	7	of	of	IN
cord-291727-4wfhuvww	166	8	-	-	HYPH
cord-291727-4wfhuvww	166	9	frame	frame	NN
cord-291727-4wfhuvww	166	10	protein	protein	NN
cord-291727-4wfhuvww	166	11	length	length	NN
cord-291727-4wfhuvww	166	12	into	into	IN
cord-291727-4wfhuvww	166	13	account	account	NN
cord-291727-4wfhuvww	166	14	might	may	MD
cord-291727-4wfhuvww	166	15	be	be	VB
cord-291727-4wfhuvww	166	16	beneficial	beneficial	JJ
cord-291727-4wfhuvww	166	17	.	.	.
cord-291727-4wfhuvww	167	1	For	for	IN
cord-291727-4wfhuvww	167	2	instance	instance	NN
cord-291727-4wfhuvww	167	3	,	,	,
cord-291727-4wfhuvww	167	4	MLOGD	MLOGD	NNP
cord-291727-4wfhuvww	167	5	(	(	-LRB-
cord-291727-4wfhuvww	167	6	http://	http://	NNP
cord-291727-4wfhuvww	167	7	guinevere.otago.ac.nz/aef/MLOGD/	guinevere.otago.ac.nz/aef/MLOGD/	NNP
cord-291727-4wfhuvww	167	8	)	)	-RRB-
cord-291727-4wfhuvww	167	9	is	be	VBZ
cord-291727-4wfhuvww	167	10	a	a	DT
cord-291727-4wfhuvww	167	11	program	program	NN
cord-291727-4wfhuvww	167	12	for	for	IN
cord-291727-4wfhuvww	167	13	detection	detection	NN
cord-291727-4wfhuvww	167	14	of	of	IN
cord-291727-4wfhuvww	167	15	overlapping	overlap	VBG
cord-291727-4wfhuvww	167	16	coding	coding	NN
cord-291727-4wfhuvww	167	17	sequences	sequence	NNS
cord-291727-4wfhuvww	167	18	based	base	VBN
cord-291727-4wfhuvww	167	19	on	on	IN
cord-291727-4wfhuvww	167	20	sequence	sequence	NN
cord-291727-4wfhuvww	167	21	alignments	alignment	NNS
cord-291727-4wfhuvww	167	22	and	and	CC
cord-291727-4wfhuvww	167	23	analysis	analysis	NN
cord-291727-4wfhuvww	167	24	of	of	IN
cord-291727-4wfhuvww	167	25	mutation	mutation	NN
cord-291727-4wfhuvww	167	26	patterns	pattern	NNS
cord-291727-4wfhuvww	167	27	(	(	-LRB-
cord-291727-4wfhuvww	167	28	Firth	Firth	NNP
cord-291727-4wfhuvww	167	29	and	and	CC
cord-291727-4wfhuvww	167	30	Brown	Brown	NNP
cord-291727-4wfhuvww	167	31	,	,	,
cord-291727-4wfhuvww	167	32	2006	2006	CD
cord-291727-4wfhuvww	167	33	)	)	-RRB-
cord-291727-4wfhuvww	167	34	.	.	.
cord-291727-4wfhuvww	168	1	The	the	DT
cord-291727-4wfhuvww	168	2	limitations	limitation	NNS
cord-291727-4wfhuvww	168	3	of	of	IN
cord-291727-4wfhuvww	168	4	this	this	DT
cord-291727-4wfhuvww	168	5	approach	approach	NN
cord-291727-4wfhuvww	168	6	are	be	VBP
cord-291727-4wfhuvww	168	7	that	that	DT
cord-291727-4wfhuvww	168	8	less	less	RBR
cord-291727-4wfhuvww	168	9	conserved	conserved	JJ
cord-291727-4wfhuvww	168	10	coding	coding	NN
cord-291727-4wfhuvww	168	11	sequences	sequence	NNS
cord-291727-4wfhuvww	168	12	will	will	MD
cord-291727-4wfhuvww	168	13	not	not	RB
cord-291727-4wfhuvww	168	14	be	be	VB
cord-291727-4wfhuvww	168	15	identified	identify	VBN
cord-291727-4wfhuvww	168	16	,	,	,
cord-291727-4wfhuvww	168	17	and	and	CC
cord-291727-4wfhuvww	168	18	-2	-2	JJ
cord-291727-4wfhuvww	168	19	frame	frame	NN
cord-291727-4wfhuvww	168	20	overlaps	overlap	NNS
cord-291727-4wfhuvww	168	21	can	can	MD
cord-291727-4wfhuvww	168	22	be	be	VB
cord-291727-4wfhuvww	168	23	identified	identify	VBN
cord-291727-4wfhuvww	168	24	as	as	IN
cord-291727-4wfhuvww	168	25	false	false	JJ
cord-291727-4wfhuvww	168	26	positives	positive	NNS
cord-291727-4wfhuvww	168	27	.	.	.
cord-291727-4wfhuvww	169	1	In	in	IN
cord-291727-4wfhuvww	169	2	some	some	DT
cord-291727-4wfhuvww	169	3	organisms	organism	NNS
cord-291727-4wfhuvww	169	4	,	,	,
cord-291727-4wfhuvww	169	5	including	include	VBG
cord-291727-4wfhuvww	169	6	mammals	mammal	NNS
cord-291727-4wfhuvww	169	7	,	,	,
cord-291727-4wfhuvww	169	8	codon	codon	NN
cord-291727-4wfhuvww	169	9	usage	usage	NN
cord-291727-4wfhuvww	169	10	has	have	VBZ
cord-291727-4wfhuvww	169	11	evolved	evolve	VBN
cord-291727-4wfhuvww	169	12	to	to	TO
cord-291727-4wfhuvww	169	13	minimize	minimize	VB
cord-291727-4wfhuvww	169	14	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	169	15	.	.	.
cord-291727-4wfhuvww	170	1	Thus	thus	RB
cord-291727-4wfhuvww	170	2	,	,	,
cord-291727-4wfhuvww	170	3	it	-PRON-	PRP
cord-291727-4wfhuvww	170	4	can	can	MD
cord-291727-4wfhuvww	170	5	be	be	VB
cord-291727-4wfhuvww	170	6	expected	expect	VBN
cord-291727-4wfhuvww	170	7	that	that	IN
cord-291727-4wfhuvww	170	8	certain	certain	JJ
cord-291727-4wfhuvww	170	9	codons	codon	NNS
cord-291727-4wfhuvww	170	10	may	may	MD
cord-291727-4wfhuvww	170	11	favour	favour	VB
cord-291727-4wfhuvww	170	12	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	170	13	.	.	.
cord-291727-4wfhuvww	171	1	FSCAN	FSCAN	NNP
cord-291727-4wfhuvww	171	2	is	be	VBZ
cord-291727-4wfhuvww	171	3	a	a	DT
cord-291727-4wfhuvww	171	4	program	program	NN
cord-291727-4wfhuvww	171	5	to	to	TO
cord-291727-4wfhuvww	171	6	identify	identify	VB
cord-291727-4wfhuvww	171	7	+1	+1	NN
cord-291727-4wfhuvww	171	8	frameshift	frameshift	NN
cord-291727-4wfhuvww	171	9	sequences	sequence	NNS
cord-291727-4wfhuvww	171	10	based	base	VBN
cord-291727-4wfhuvww	171	11	on	on	IN
cord-291727-4wfhuvww	171	12	codon	codon	NN
cord-291727-4wfhuvww	171	13	usage	usage	NN
cord-291727-4wfhuvww	171	14	in	in	IN
cord-291727-4wfhuvww	171	15	E.	E.	NNP
cord-291727-4wfhuvww	171	16	coli	coli	NNS
cord-291727-4wfhuvww	171	17	.	.	.
cord-291727-4wfhuvww	172	1	FScan	fscan	JJ
cord-291727-4wfhuvww	172	2	searches	search	VBZ
cord-291727-4wfhuvww	172	3	16	16	CD
cord-291727-4wfhuvww	172	4	nt	nt	NN
cord-291727-4wfhuvww	172	5	sequences	sequence	NNS
cord-291727-4wfhuvww	172	6	and	and	CC
cord-291727-4wfhuvww	172	7	calculates	calculate	VBZ
cord-291727-4wfhuvww	172	8	a	a	DT
cord-291727-4wfhuvww	172	9	score	score	NN
cord-291727-4wfhuvww	172	10	for	for	IN
cord-291727-4wfhuvww	172	11	aa	aa	NNP
cord-291727-4wfhuvww	172	12	-	-	HYPH
cord-291727-4wfhuvww	172	13	tRNA	tRNA	NNP
cord-291727-4wfhuvww	172	14	competition	competition	NN
cord-291727-4wfhuvww	172	15	between	between	IN
cord-291727-4wfhuvww	172	16	the	the	DT
cord-291727-4wfhuvww	172	17	zero	zero	CD
cord-291727-4wfhuvww	172	18	and	and	CC
cord-291727-4wfhuvww	172	19	+1	+1	NN
cord-291727-4wfhuvww	172	20	frame	frame	NN
cord-291727-4wfhuvww	172	21	.	.	.
cord-291727-4wfhuvww	173	1	Accordingly	accordingly	RB
cord-291727-4wfhuvww	173	2	,	,	,
cord-291727-4wfhuvww	173	3	a	a	DT
cord-291727-4wfhuvww	173	4	stop	stop	NN
cord-291727-4wfhuvww	173	5	codon	codon	NN
cord-291727-4wfhuvww	173	6	,	,	,
cord-291727-4wfhuvww	173	7	or	or	CC
cord-291727-4wfhuvww	173	8	a	a	DT
cord-291727-4wfhuvww	173	9	rare	rare	JJ
cord-291727-4wfhuvww	173	10	codon	codon	NN
cord-291727-4wfhuvww	173	11	in	in	IN
cord-291727-4wfhuvww	173	12	the	the	DT
cord-291727-4wfhuvww	173	13	zero	zero	CD
cord-291727-4wfhuvww	173	14	frame	frame	NN
cord-291727-4wfhuvww	173	15	can	can	MD
cord-291727-4wfhuvww	173	16	be	be	VB
cord-291727-4wfhuvww	173	17	a	a	DT
cord-291727-4wfhuvww	173	18	predictor	predictor	NN
cord-291727-4wfhuvww	173	19	of	of	IN
cord-291727-4wfhuvww	173	20	+1	+1	HYPH
cord-291727-4wfhuvww	173	21	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	173	22	.	.	.
cord-291727-4wfhuvww	174	1	Shah	Shah	NNP
cord-291727-4wfhuvww	174	2	et	et	NNP
cord-291727-4wfhuvww	174	3	al	al	NNP
cord-291727-4wfhuvww	174	4	.	.	NNP
cord-291727-4wfhuvww	174	5	suggested	suggest	VBD
cord-291727-4wfhuvww	174	6	that	that	IN
cord-291727-4wfhuvww	174	7	selective	selective	JJ
cord-291727-4wfhuvww	174	8	pressure	pressure	NN
cord-291727-4wfhuvww	174	9	would	would	MD
cord-291727-4wfhuvww	174	10	lead	lead	VB
cord-291727-4wfhuvww	174	11	to	to	IN
cord-291727-4wfhuvww	174	12	an	an	DT
cord-291727-4wfhuvww	174	13	under	under	IN
cord-291727-4wfhuvww	174	14	-	-	HYPH
cord-291727-4wfhuvww	174	15	representation	representation	NN
cord-291727-4wfhuvww	174	16	of	of	IN
cord-291727-4wfhuvww	174	17	frameshift	frameshift	NN
cord-291727-4wfhuvww	174	18	sites	site	NNS
cord-291727-4wfhuvww	174	19	in	in	IN
cord-291727-4wfhuvww	174	20	protein	protein	NN
cord-291727-4wfhuvww	174	21	-	-	HYPH
cord-291727-4wfhuvww	174	22	coding	code	VBG
cord-291727-4wfhuvww	174	23	sequences	sequence	NNS
cord-291727-4wfhuvww	174	24	relative	relative	JJ
cord-291727-4wfhuvww	174	25	to	to	IN
cord-291727-4wfhuvww	174	26	an	an	DT
cord-291727-4wfhuvww	174	27	organism	organism	NN
cord-291727-4wfhuvww	174	28	's	's	POS
cord-291727-4wfhuvww	174	29	codon	codon	NN
cord-291727-4wfhuvww	174	30	bias	bias	NN
cord-291727-4wfhuvww	174	31	(	(	-LRB-
cord-291727-4wfhuvww	174	32	Shah	Shah	NNP
cord-291727-4wfhuvww	174	33	et	et	NNP
cord-291727-4wfhuvww	174	34	al	al	NNP
cord-291727-4wfhuvww	174	35	.	.	NNP
cord-291727-4wfhuvww	174	36	,	,	,
cord-291727-4wfhuvww	174	37	2002	2002	CD
cord-291727-4wfhuvww	174	38	)	)	-RRB-
cord-291727-4wfhuvww	174	39	.	.	.
cord-291727-4wfhuvww	175	1	They	-PRON-	PRP
cord-291727-4wfhuvww	175	2	predicted	predict	VBD
cord-291727-4wfhuvww	175	3	the	the	DT
cord-291727-4wfhuvww	175	4	sequences	sequence	NNS
cord-291727-4wfhuvww	175	5	CUU	CUU	NNP
cord-291727-4wfhuvww	175	6	AGG	agg	NN
cord-291727-4wfhuvww	175	7	C	c	NN
cord-291727-4wfhuvww	175	8	and	and	CC
cord-291727-4wfhuvww	175	9	CUU	CUU	NNP
cord-291727-4wfhuvww	175	10	AGU	AGU	NNP
cord-291727-4wfhuvww	175	11	U	U	NNP
cord-291727-4wfhuvww	175	12	,	,	,
cord-291727-4wfhuvww	175	13	which	which	WDT
cord-291727-4wfhuvww	175	14	mediate	mediate	VBP
cord-291727-4wfhuvww	175	15	+1	+1	NN
cord-291727-4wfhuvww	175	16	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	175	17	of	of	IN
cord-291727-4wfhuvww	175	18	ABP140	ABP140	NNP
cord-291727-4wfhuvww	175	19	and	and	CC
cord-291727-4wfhuvww	175	20	EST3	EST3	NNP
cord-291727-4wfhuvww	175	21	,	,	,
cord-291727-4wfhuvww	175	22	respectively	respectively	RB
cord-291727-4wfhuvww	175	23	,	,	,
cord-291727-4wfhuvww	175	24	to	to	TO
cord-291727-4wfhuvww	175	25	be	be	VB
cord-291727-4wfhuvww	175	26	highly	highly	RB
cord-291727-4wfhuvww	175	27	under	under	RB
cord-291727-4wfhuvww	175	28	-	-	HYPH
cord-291727-4wfhuvww	175	29	represented	represent	VBN
cord-291727-4wfhuvww	175	30	and	and	CC
cord-291727-4wfhuvww	175	31	predictive	predictive	JJ
cord-291727-4wfhuvww	175	32	for	for	IN
cord-291727-4wfhuvww	175	33	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	175	34	in	in	IN
cord-291727-4wfhuvww	175	35	S.	S.	NNP
cord-291727-4wfhuvww	175	36	cerevisiae	cerevisiae	NNS
cord-291727-4wfhuvww	175	37	.	.	.
cord-291727-4wfhuvww	176	1	Once	once	IN
cord-291727-4wfhuvww	176	2	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	176	3	events	event	NNS
cord-291727-4wfhuvww	176	4	have	have	VBP
cord-291727-4wfhuvww	176	5	been	be	VBN
cord-291727-4wfhuvww	176	6	identified	identify	VBN
cord-291727-4wfhuvww	176	7	,	,	,
cord-291727-4wfhuvww	176	8	it	-PRON-	PRP
cord-291727-4wfhuvww	176	9	is	be	VBZ
cord-291727-4wfhuvww	176	10	important	important	JJ
cord-291727-4wfhuvww	176	11	to	to	TO
cord-291727-4wfhuvww	176	12	characterize	characterize	VB
cord-291727-4wfhuvww	176	13	the	the	DT
cord-291727-4wfhuvww	176	14	gene	gene	NN
cord-291727-4wfhuvww	176	15	products	product	NNS
cord-291727-4wfhuvww	176	16	.	.	.
cord-291727-4wfhuvww	177	1	One	one	PRP
cord-291727-4wfhuvww	177	2	could	could	MD
cord-291727-4wfhuvww	177	3	apply	apply	VB
cord-291727-4wfhuvww	177	4	the	the	DT
cord-291727-4wfhuvww	177	5	filters	filter	NNS
cord-291727-4wfhuvww	177	6	mentioned	mention	VBN
cord-291727-4wfhuvww	177	7	above	above	RB
cord-291727-4wfhuvww	177	8	,	,	,
cord-291727-4wfhuvww	177	9	such	such	JJ
cord-291727-4wfhuvww	177	10	as	as	IN
cord-291727-4wfhuvww	177	11	the	the	DT
cord-291727-4wfhuvww	177	12	50-nt	50-nt	CD
cord-291727-4wfhuvww	177	13	rule	rule	NN
cord-291727-4wfhuvww	177	14	,	,	,
cord-291727-4wfhuvww	177	15	although	although	IN
cord-291727-4wfhuvww	177	16	it	-PRON-	PRP
cord-291727-4wfhuvww	177	17	is	be	VBZ
cord-291727-4wfhuvww	177	18	quite	quite	RB
cord-291727-4wfhuvww	177	19	possible	possible	JJ
cord-291727-4wfhuvww	177	20	that	that	IN
cord-291727-4wfhuvww	177	21	short	short	JJ
cord-291727-4wfhuvww	177	22	peptides	peptide	NNS
cord-291727-4wfhuvww	177	23	are	be	VBP
cord-291727-4wfhuvww	177	24	stable	stable	JJ
cord-291727-4wfhuvww	177	25	and	and	CC
cord-291727-4wfhuvww	177	26	endogenously	endogenously	RB
cord-291727-4wfhuvww	177	27	expressed	express	VBN
cord-291727-4wfhuvww	178	1	(	(	-LRB-
cord-291727-4wfhuvww	178	2	Kondo	Kondo	NNP
cord-291727-4wfhuvww	178	3	et	et	NNP
cord-291727-4wfhuvww	178	4	al	al	NNP
cord-291727-4wfhuvww	178	5	.	.	NNP
cord-291727-4wfhuvww	178	6	,	,	,
cord-291727-4wfhuvww	178	7	2010	2010	CD
cord-291727-4wfhuvww	178	8	;	;	:
cord-291727-4wfhuvww	178	9	Ingolia	Ingolia	NNP
cord-291727-4wfhuvww	178	10	et	et	NNP
cord-291727-4wfhuvww	178	11	al	al	NNP
cord-291727-4wfhuvww	178	12	.	.	NNP
cord-291727-4wfhuvww	178	13	,	,	,
cord-291727-4wfhuvww	178	14	2011	2011	CD
cord-291727-4wfhuvww	178	15	)	)	-RRB-
cord-291727-4wfhuvww	178	16	.	.	.
cord-291727-4wfhuvww	179	1	Ultimately	ultimately	RB
cord-291727-4wfhuvww	179	2	,	,	,
cord-291727-4wfhuvww	179	3	all	all	DT
cord-291727-4wfhuvww	179	4	predictions	prediction	NNS
cord-291727-4wfhuvww	179	5	of	of	IN
cord-291727-4wfhuvww	179	6	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	179	7	peptides	peptide	NNS
cord-291727-4wfhuvww	179	8	need	need	VBP
cord-291727-4wfhuvww	179	9	to	to	TO
cord-291727-4wfhuvww	179	10	be	be	VB
cord-291727-4wfhuvww	179	11	validated	validate	VBN
cord-291727-4wfhuvww	179	12	with	with	IN
cord-291727-4wfhuvww	179	13	experimental	experimental	JJ
cord-291727-4wfhuvww	179	14	methods	method	NNS
cord-291727-4wfhuvww	179	15	.	.	.
cord-291727-4wfhuvww	180	1	Experimental	experimental	JJ
cord-291727-4wfhuvww	180	2	methods	method	NNS
cord-291727-4wfhuvww	180	3	include	include	VBP
cord-291727-4wfhuvww	180	4	generation	generation	NN
cord-291727-4wfhuvww	180	5	of	of	IN
cord-291727-4wfhuvww	180	6	frameshift	frameshift	NN
cord-291727-4wfhuvww	180	7	-	-	HYPH
cord-291727-4wfhuvww	180	8	specific	specific	JJ
cord-291727-4wfhuvww	180	9	antibodies	antibody	NNS
cord-291727-4wfhuvww	180	10	,	,	,
cord-291727-4wfhuvww	180	11	reporter	reporter	NN
cord-291727-4wfhuvww	180	12	constructs	construct	NNS
cord-291727-4wfhuvww	180	13	,	,	,
cord-291727-4wfhuvww	180	14	biophysical	biophysical	JJ
cord-291727-4wfhuvww	180	15	methods	method	NNS
cord-291727-4wfhuvww	180	16	,	,	,
cord-291727-4wfhuvww	180	17	and	and	CC
cord-291727-4wfhuvww	180	18	single	single	JJ
cord-291727-4wfhuvww	180	19	molecule	molecule	NN
cord-291727-4wfhuvww	180	20	measurements	measurement	NNS
cord-291727-4wfhuvww	180	21	.	.	.
cord-291727-4wfhuvww	181	1	The	the	DT
cord-291727-4wfhuvww	181	2	most	most	RBS
cord-291727-4wfhuvww	181	3	commonly	commonly	RB
cord-291727-4wfhuvww	181	4	used	use	VBN
cord-291727-4wfhuvww	181	5	frameshift	frameshift	NN
cord-291727-4wfhuvww	181	6	reporter	reporter	NN
cord-291727-4wfhuvww	181	7	is	be	VBZ
cord-291727-4wfhuvww	181	8	a	a	DT
cord-291727-4wfhuvww	181	9	tandem	tandem	JJ
cord-291727-4wfhuvww	181	10	luciferase	luciferase	FW
cord-291727-4wfhuvww	181	11	construct	construct	NN
cord-291727-4wfhuvww	181	12	where	where	WRB
cord-291727-4wfhuvww	181	13	the	the	DT
cord-291727-4wfhuvww	181	14	two	two	CD
cord-291727-4wfhuvww	181	15	luciferases	luciferase	NNS
cord-291727-4wfhuvww	181	16	with	with	IN
cord-291727-4wfhuvww	181	17	different	different	JJ
cord-291727-4wfhuvww	181	18	substrate	substrate	NN
cord-291727-4wfhuvww	181	19	specificities	specificity	NNS
cord-291727-4wfhuvww	181	20	are	be	VBP
cord-291727-4wfhuvww	181	21	separated	separate	VBN
cord-291727-4wfhuvww	181	22	by	by	IN
cord-291727-4wfhuvww	181	23	a	a	DT
cord-291727-4wfhuvww	181	24	stretch	stretch	NN
cord-291727-4wfhuvww	181	25	of	of	IN
cord-291727-4wfhuvww	181	26	nucleotides	nucleotide	NNS
cord-291727-4wfhuvww	181	27	of	of	IN
cord-291727-4wfhuvww	181	28	a	a	DT
cord-291727-4wfhuvww	181	29	length	length	NN
cord-291727-4wfhuvww	181	30	that	that	WDT
cord-291727-4wfhuvww	181	31	shifts	shift	VBZ
cord-291727-4wfhuvww	181	32	the	the	DT
cord-291727-4wfhuvww	181	33	downstream	downstream	JJ
cord-291727-4wfhuvww	181	34	luciferase	luciferase	NN
cord-291727-4wfhuvww	182	1	either	either	CC
cord-291727-4wfhuvww	182	2	one	one	CD
cord-291727-4wfhuvww	182	3	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	182	4	up	up	IN
cord-291727-4wfhuvww	182	5	or	or	CC
cord-291727-4wfhuvww	182	6	down	down	RB
cord-291727-4wfhuvww	183	1	(	(	-LRB-
cord-291727-4wfhuvww	183	2	Grentzmann	Grentzmann	NNP
cord-291727-4wfhuvww	183	3	et	et	FW
cord-291727-4wfhuvww	183	4	al	al	NNP
cord-291727-4wfhuvww	183	5	.	.	NNP
cord-291727-4wfhuvww	183	6	,	,	,
cord-291727-4wfhuvww	183	7	1998	1998	CD
cord-291727-4wfhuvww	183	8	)	)	-RRB-
cord-291727-4wfhuvww	183	9	.	.	.
cord-291727-4wfhuvww	184	1	The	the	DT
cord-291727-4wfhuvww	184	2	downstream	downstream	JJ
cord-291727-4wfhuvww	184	3	luciferase	luciferase	NN
cord-291727-4wfhuvww	184	4	will	will	MD
cord-291727-4wfhuvww	184	5	be	be	VB
cord-291727-4wfhuvww	184	6	expressed	express	VBN
cord-291727-4wfhuvww	184	7	only	only	RB
cord-291727-4wfhuvww	184	8	if	if	IN
cord-291727-4wfhuvww	184	9	the	the	DT
cord-291727-4wfhuvww	184	10	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	184	11	stretch	stretch	NN
cord-291727-4wfhuvww	184	12	can	can	MD
cord-291727-4wfhuvww	184	13	mediate	mediate	VB
cord-291727-4wfhuvww	184	14	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	184	15	,	,	,
cord-291727-4wfhuvww	184	16	while	while	IN
cord-291727-4wfhuvww	184	17	the	the	DT
cord-291727-4wfhuvww	184	18	upstream	upstream	JJ
cord-291727-4wfhuvww	184	19	luciferase	luciferase	NN
cord-291727-4wfhuvww	184	20	serves	serve	VBZ
cord-291727-4wfhuvww	184	21	as	as	IN
cord-291727-4wfhuvww	184	22	an	an	DT
cord-291727-4wfhuvww	184	23	expression	expression	NN
cord-291727-4wfhuvww	184	24	control	control	NN
cord-291727-4wfhuvww	184	25	.	.	.
cord-291727-4wfhuvww	185	1	Alternative	alternative	JJ
cord-291727-4wfhuvww	185	2	reporter	reporter	NN
cord-291727-4wfhuvww	185	3	genes	gene	NNS
cord-291727-4wfhuvww	185	4	include	include	VBP
cord-291727-4wfhuvww	185	5	the	the	DT
cord-291727-4wfhuvww	185	6	use	use	NN
cord-291727-4wfhuvww	185	7	of	of	IN
cord-291727-4wfhuvww	185	8	fluorescent	fluorescent	NN
cord-291727-4wfhuvww	185	9	proteins	protein	NNS
cord-291727-4wfhuvww	185	10	(	(	-LRB-
cord-291727-4wfhuvww	185	11	Cardno	Cardno	NNP
cord-291727-4wfhuvww	185	12	et	et	FW
cord-291727-4wfhuvww	185	13	al	al	NNP
cord-291727-4wfhuvww	185	14	.	.	NNP
cord-291727-4wfhuvww	185	15	,	,	,
cord-291727-4wfhuvww	185	16	2009	2009	CD
cord-291727-4wfhuvww	185	17	)	)	-RRB-
cord-291727-4wfhuvww	185	18	,	,	,
cord-291727-4wfhuvww	185	19	although	although	IN
cord-291727-4wfhuvww	185	20	the	the	DT
cord-291727-4wfhuvww	185	21	dynamic	dynamic	JJ
cord-291727-4wfhuvww	185	22	range	range	NN
cord-291727-4wfhuvww	185	23	of	of	IN
cord-291727-4wfhuvww	185	24	luciferases	luciferases	NNP
cord-291727-4wfhuvww	185	25	is	be	VBZ
cord-291727-4wfhuvww	185	26	generally	generally	RB
cord-291727-4wfhuvww	185	27	much	much	RB
cord-291727-4wfhuvww	185	28	higher	high	JJR
cord-291727-4wfhuvww	185	29	.	.	.
cord-291727-4wfhuvww	186	1	This	this	DT
cord-291727-4wfhuvww	186	2	reporter	reporter	NN
cord-291727-4wfhuvww	186	3	can	can	MD
cord-291727-4wfhuvww	186	4	be	be	VB
cord-291727-4wfhuvww	186	5	used	use	VBN
cord-291727-4wfhuvww	186	6	experimentally	experimentally	RB
cord-291727-4wfhuvww	186	7	to	to	TO
cord-291727-4wfhuvww	186	8	confirm	confirm	VB
cord-291727-4wfhuvww	186	9	predicted	predict	VBN
cord-291727-4wfhuvww	186	10	frameshift	frameshift	NN
cord-291727-4wfhuvww	186	11	events	event	NNS
cord-291727-4wfhuvww	186	12	.	.	.
cord-291727-4wfhuvww	187	1	One	one	CD
cord-291727-4wfhuvww	187	2	hypothesis	hypothesis	NN
cord-291727-4wfhuvww	187	3	is	be	VBZ
cord-291727-4wfhuvww	187	4	that	that	IN
cord-291727-4wfhuvww	187	5	the	the	DT
cord-291727-4wfhuvww	187	6	−1	−1	NNP
cord-291727-4wfhuvww	187	7	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	187	8	efficiency	efficiency	NN
cord-291727-4wfhuvww	187	9	correlates	correlate	VBZ
cord-291727-4wfhuvww	187	10	with	with	IN
cord-291727-4wfhuvww	187	11	the	the	DT
cord-291727-4wfhuvww	187	12	mechanical	mechanical	JJ
cord-291727-4wfhuvww	187	13	force	force	NN
cord-291727-4wfhuvww	187	14	required	require	VBN
cord-291727-4wfhuvww	187	15	for	for	IN
cord-291727-4wfhuvww	187	16	pulling	pull	VBG
cord-291727-4wfhuvww	187	17	the	the	DT
cord-291727-4wfhuvww	187	18	RNA	RNA	NNP
cord-291727-4wfhuvww	187	19	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	187	20	apart	apart	RB
cord-291727-4wfhuvww	187	21	.	.	.
cord-291727-4wfhuvww	188	1	With	with	IN
cord-291727-4wfhuvww	188	2	biophysical	biophysical	JJ
cord-291727-4wfhuvww	188	3	single	single	JJ
cord-291727-4wfhuvww	188	4	-	-	HYPH
cord-291727-4wfhuvww	188	5	molecule	molecule	NN
cord-291727-4wfhuvww	188	6	methods	method	NNS
cord-291727-4wfhuvww	188	7	that	that	WDT
cord-291727-4wfhuvww	188	8	measure	measure	VBP
cord-291727-4wfhuvww	188	9	these	these	DT
cord-291727-4wfhuvww	188	10	forces	force	NNS
cord-291727-4wfhuvww	188	11	using	use	VBG
cord-291727-4wfhuvww	188	12	optical	optical	JJ
cord-291727-4wfhuvww	188	13	tweezers	tweezer	NNS
cord-291727-4wfhuvww	188	14	,	,	,
cord-291727-4wfhuvww	188	15	Hansen	Hansen	NNP
cord-291727-4wfhuvww	188	16	et	et	NNP
cord-291727-4wfhuvww	188	17	al	al	NNP
cord-291727-4wfhuvww	188	18	.	.	NNP
cord-291727-4wfhuvww	188	19	have	have	VBP
cord-291727-4wfhuvww	188	20	confirmed	confirm	VBN
cord-291727-4wfhuvww	188	21	that	that	IN
cord-291727-4wfhuvww	188	22	unfolding	unfold	VBG
cord-291727-4wfhuvww	188	23	of	of	IN
cord-291727-4wfhuvww	188	24	a	a	DT
cord-291727-4wfhuvww	188	25	IBV	IBV	NNP
cord-291727-4wfhuvww	188	26	-	-	HYPH
cord-291727-4wfhuvww	188	27	based	base	VBN
cord-291727-4wfhuvww	188	28	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	188	29	required	require	VBD
cord-291727-4wfhuvww	188	30	∼500	∼500	NNP
cord-291727-4wfhuvww	188	31	kJ	kJ	NNP
cord-291727-4wfhuvww	188	32	/	/	SYM
cord-291727-4wfhuvww	188	33	mol	mol	NN
cord-291727-4wfhuvww	188	34	,	,	,
cord-291727-4wfhuvww	188	35	compared	compare	VBN
cord-291727-4wfhuvww	188	36	to	to	IN
cord-291727-4wfhuvww	188	37	the	the	DT
cord-291727-4wfhuvww	188	38	theoretically	theoretically	RB
cord-291727-4wfhuvww	188	39	determined	determine	VBN
cord-291727-4wfhuvww	188	40	292	292	CD
cord-291727-4wfhuvww	188	41	kJ	kJ	NNP
cord-291727-4wfhuvww	188	42	/	/	SYM
cord-291727-4wfhuvww	188	43	mol	mol	NN
cord-291727-4wfhuvww	188	44	(	(	-LRB-
cord-291727-4wfhuvww	188	45	Hansen	Hansen	NNP
cord-291727-4wfhuvww	188	46	et	et	NNP
cord-291727-4wfhuvww	188	47	al	al	NNP
cord-291727-4wfhuvww	188	48	.	.	NNP
cord-291727-4wfhuvww	188	49	,	,	,
cord-291727-4wfhuvww	188	50	2007	2007	CD
cord-291727-4wfhuvww	188	51	)	)	-RRB-
cord-291727-4wfhuvww	188	52	.	.	.
cord-291727-4wfhuvww	189	1	Chen	Chen	NNP
cord-291727-4wfhuvww	189	2	et	et	NNP
cord-291727-4wfhuvww	189	3	al	al	NNP
cord-291727-4wfhuvww	189	4	.	.	NNP
cord-291727-4wfhuvww	189	5	have	have	VBP
cord-291727-4wfhuvww	189	6	determined	determine	VBN
cord-291727-4wfhuvww	189	7	that	that	IN
cord-291727-4wfhuvww	189	8	a	a	DT
cord-291727-4wfhuvww	189	9	100	100	CD
cord-291727-4wfhuvww	189	10	%	%	NN
cord-291727-4wfhuvww	189	11	confidence	confidence	NN
cord-291727-4wfhuvww	189	12	in	in	IN
cord-291727-4wfhuvww	189	13	−1	−1	NNP
cord-291727-4wfhuvww	189	14	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	189	15	is	be	VBZ
cord-291727-4wfhuvww	189	16	reached	reach	VBN
cord-291727-4wfhuvww	189	17	by	by	IN
cord-291727-4wfhuvww	189	18	an	an	DT
cord-291727-4wfhuvww	189	19	unfolding	unfold	VBG
cord-291727-4wfhuvww	189	20	force	force	NN
cord-291727-4wfhuvww	189	21	of	of	IN
cord-291727-4wfhuvww	190	1	∼57	∼57	NNP
cord-291727-4wfhuvww	190	2	pN	pN	NNP
cord-291727-4wfhuvww	190	3	(	(	-LRB-
cord-291727-4wfhuvww	190	4	Chen	Chen	NNP
cord-291727-4wfhuvww	190	5	et	et	NNP
cord-291727-4wfhuvww	190	6	al	al	NNP
cord-291727-4wfhuvww	190	7	.	.	NNP
cord-291727-4wfhuvww	190	8	,	,	,
cord-291727-4wfhuvww	190	9	2009	2009	CD
cord-291727-4wfhuvww	190	10	)	)	-RRB-
cord-291727-4wfhuvww	190	11	.	.	.
cord-291727-4wfhuvww	191	1	Such	such	JJ
cord-291727-4wfhuvww	191	2	single	single	JJ
cord-291727-4wfhuvww	191	3	-	-	HYPH
cord-291727-4wfhuvww	191	4	molecule	molecule	NN
cord-291727-4wfhuvww	191	5	biophysical	biophysical	JJ
cord-291727-4wfhuvww	191	6	approaches	approach	NNS
cord-291727-4wfhuvww	191	7	may	may	MD
cord-291727-4wfhuvww	191	8	help	help	VB
cord-291727-4wfhuvww	191	9	to	to	TO
cord-291727-4wfhuvww	191	10	identify	identify	VB
cord-291727-4wfhuvww	191	11	potential	potential	JJ
cord-291727-4wfhuvww	191	12	frameshift	frameshift	NN
cord-291727-4wfhuvww	191	13	sequences	sequence	NNS
cord-291727-4wfhuvww	191	14	,	,	,
cord-291727-4wfhuvww	191	15	but	but	CC
cord-291727-4wfhuvww	191	16	as	as	IN
cord-291727-4wfhuvww	191	17	they	-PRON-	PRP
cord-291727-4wfhuvww	191	18	require	require	VBP
cord-291727-4wfhuvww	191	19	immobilization	immobilization	NN
cord-291727-4wfhuvww	191	20	of	of	IN
cord-291727-4wfhuvww	191	21	the	the	DT
cord-291727-4wfhuvww	191	22	RNA	RNA	NNP
cord-291727-4wfhuvww	191	23	,	,	,
cord-291727-4wfhuvww	191	24	they	-PRON-	PRP
cord-291727-4wfhuvww	191	25	will	will	MD
cord-291727-4wfhuvww	191	26	be	be	VB
cord-291727-4wfhuvww	191	27	technically	technically	RB
cord-291727-4wfhuvww	191	28	challenging	challenging	JJ
cord-291727-4wfhuvww	191	29	to	to	TO
cord-291727-4wfhuvww	191	30	implement	implement	VB
cord-291727-4wfhuvww	191	31	on	on	IN
cord-291727-4wfhuvww	191	32	a	a	DT
cord-291727-4wfhuvww	191	33	genome	genome	NN
cord-291727-4wfhuvww	191	34	-	-	HYPH
cord-291727-4wfhuvww	191	35	wide	wide	JJ
cord-291727-4wfhuvww	191	36	scale	scale	NN
cord-291727-4wfhuvww	191	37	.	.	.
cord-291727-4wfhuvww	192	1	An	an	DT
cord-291727-4wfhuvww	192	2	alternative	alternative	NN
cord-291727-4wfhuvww	192	3	is	be	VBZ
cord-291727-4wfhuvww	192	4	the	the	DT
cord-291727-4wfhuvww	192	5	use	use	NN
cord-291727-4wfhuvww	192	6	of	of	IN
cord-291727-4wfhuvww	192	7	single	single	JJ
cord-291727-4wfhuvww	192	8	molecule	molecule	NN
cord-291727-4wfhuvww	192	9	Foerster	Foerster	NNP
cord-291727-4wfhuvww	192	10	Resonance	Resonance	NNP
cord-291727-4wfhuvww	192	11	Energy	Energy	NNP
cord-291727-4wfhuvww	192	12	Transfer	Transfer	NNP
cord-291727-4wfhuvww	192	13	(	(	-LRB-
cord-291727-4wfhuvww	192	14	smFRET	smfret	NN
cord-291727-4wfhuvww	192	15	)	)	-RRB-
cord-291727-4wfhuvww	192	16	(	(	-LRB-
cord-291727-4wfhuvww	192	17	Aitken	Aitken	NNP
cord-291727-4wfhuvww	192	18	and	and	CC
cord-291727-4wfhuvww	192	19	Puglisi	Puglisi	NNP
cord-291727-4wfhuvww	192	20	,	,	,
cord-291727-4wfhuvww	192	21	2010	2010	CD
cord-291727-4wfhuvww	192	22	)	)	-RRB-
cord-291727-4wfhuvww	192	23	.	.	.
cord-291727-4wfhuvww	193	1	FRET	fret	NN
cord-291727-4wfhuvww	193	2	is	be	VBZ
cord-291727-4wfhuvww	193	3	a	a	DT
cord-291727-4wfhuvww	193	4	useful	useful	JJ
cord-291727-4wfhuvww	193	5	technique	technique	NN
cord-291727-4wfhuvww	193	6	to	to	TO
cord-291727-4wfhuvww	193	7	measure	measure	VB
cord-291727-4wfhuvww	193	8	proximity	proximity	NN
cord-291727-4wfhuvww	193	9	of	of	IN
cord-291727-4wfhuvww	193	10	biomolecules	biomolecule	NNS
cord-291727-4wfhuvww	193	11	.	.	.
cord-291727-4wfhuvww	194	1	A	a	DT
cord-291727-4wfhuvww	194	2	donor	donor	NN
cord-291727-4wfhuvww	194	3	fluorophore	fluorophore	NN
cord-291727-4wfhuvww	194	4	attached	attach	VBN
cord-291727-4wfhuvww	194	5	to	to	IN
cord-291727-4wfhuvww	194	6	a	a	DT
cord-291727-4wfhuvww	194	7	molecule	molecule	NN
cord-291727-4wfhuvww	194	8	can	can	MD
cord-291727-4wfhuvww	194	9	transfer	transfer	VB
cord-291727-4wfhuvww	194	10	photons	photon	NNS
cord-291727-4wfhuvww	194	11	to	to	IN
cord-291727-4wfhuvww	194	12	an	an	DT
cord-291727-4wfhuvww	194	13	acceptor	acceptor	NN
cord-291727-4wfhuvww	194	14	fluorophore	fluorophore	NN
cord-291727-4wfhuvww	194	15	on	on	IN
cord-291727-4wfhuvww	194	16	a	a	DT
cord-291727-4wfhuvww	194	17	different	different	JJ
cord-291727-4wfhuvww	194	18	molecule	molecule	NN
cord-291727-4wfhuvww	194	19	when	when	WRB
cord-291727-4wfhuvww	194	20	both	both	DT
cord-291727-4wfhuvww	194	21	molecules	molecule	NNS
cord-291727-4wfhuvww	194	22	are	be	VBP
cord-291727-4wfhuvww	194	23	close	close	JJ
cord-291727-4wfhuvww	194	24	together	together	RB
cord-291727-4wfhuvww	194	25	(	(	-LRB-
cord-291727-4wfhuvww	194	26	generally	generally	RB
cord-291727-4wfhuvww	194	27	less	less	JJR
cord-291727-4wfhuvww	194	28	than	than	IN
cord-291727-4wfhuvww	194	29	10	10	CD
cord-291727-4wfhuvww	194	30	nm	nm	NN
cord-291727-4wfhuvww	194	31	)	)	-RRB-
cord-291727-4wfhuvww	194	32	.	.	.
cord-291727-4wfhuvww	195	1	Aitken	Aitken	NNP
cord-291727-4wfhuvww	195	2	and	and	CC
cord-291727-4wfhuvww	195	3	Puglisi	Puglisi	NNP
cord-291727-4wfhuvww	195	4	have	have	VBP
cord-291727-4wfhuvww	195	5	used	use	VBN
cord-291727-4wfhuvww	195	6	this	this	DT
cord-291727-4wfhuvww	195	7	technique	technique	NN
cord-291727-4wfhuvww	195	8	to	to	TO
cord-291727-4wfhuvww	195	9	label	label	VB
cord-291727-4wfhuvww	195	10	individual	individual	JJ
cord-291727-4wfhuvww	195	11	tRNA	trna	NN
cord-291727-4wfhuvww	195	12	molecules	molecule	NNS
cord-291727-4wfhuvww	195	13	with	with	IN
cord-291727-4wfhuvww	195	14	donor	donor	NN
cord-291727-4wfhuvww	195	15	and	and	CC
cord-291727-4wfhuvww	195	16	acceptor	acceptor	NN
cord-291727-4wfhuvww	195	17	dyes	dye	NNS
cord-291727-4wfhuvww	195	18	that	that	WDT
cord-291727-4wfhuvww	195	19	result	result	VBP
cord-291727-4wfhuvww	195	20	in	in	IN
cord-291727-4wfhuvww	195	21	energy	energy	NN
cord-291727-4wfhuvww	195	22	transfer	transfer	NN
cord-291727-4wfhuvww	195	23	when	when	WRB
cord-291727-4wfhuvww	195	24	in	in	IN
cord-291727-4wfhuvww	195	25	close	close	JJ
cord-291727-4wfhuvww	195	26	proximity	proximity	NN
cord-291727-4wfhuvww	195	27	and	and	CC
cord-291727-4wfhuvww	195	28	correct	correct	JJ
cord-291727-4wfhuvww	195	29	orientation	orientation	NN
cord-291727-4wfhuvww	195	30	.	.	.
cord-291727-4wfhuvww	196	1	This	this	DT
cord-291727-4wfhuvww	196	2	technique	technique	NN
cord-291727-4wfhuvww	196	3	enables	enable	VBZ
cord-291727-4wfhuvww	196	4	to	to	TO
cord-291727-4wfhuvww	196	5	monitor	monitor	VB
cord-291727-4wfhuvww	196	6	relative	relative	JJ
cord-291727-4wfhuvww	196	7	tRNA	tRNA	NNP
cord-291727-4wfhuvww	196	8	positions	position	NNS
cord-291727-4wfhuvww	196	9	and	and	CC
cord-291727-4wfhuvww	196	10	movement	movement	NN
cord-291727-4wfhuvww	196	11	of	of	IN
cord-291727-4wfhuvww	196	12	tRNAs	trna	NNS
cord-291727-4wfhuvww	196	13	on	on	IN
cord-291727-4wfhuvww	196	14	ribosomes	ribosome	NNS
cord-291727-4wfhuvww	196	15	at	at	IN
cord-291727-4wfhuvww	196	16	a	a	DT
cord-291727-4wfhuvww	196	17	millisecond	millisecond	NN
cord-291727-4wfhuvww	196	18	scale	scale	NN
cord-291727-4wfhuvww	196	19	.	.	.
cord-291727-4wfhuvww	197	1	It	-PRON-	PRP
cord-291727-4wfhuvww	197	2	has	have	VBZ
cord-291727-4wfhuvww	197	3	been	be	VBN
cord-291727-4wfhuvww	197	4	used	use	VBN
cord-291727-4wfhuvww	197	5	to	to	TO
cord-291727-4wfhuvww	197	6	identify	identify	VB
cord-291727-4wfhuvww	197	7	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	197	8	translocation	translocation	NN
cord-291727-4wfhuvww	197	9	events	event	NNS
cord-291727-4wfhuvww	197	10	on	on	IN
cord-291727-4wfhuvww	197	11	fluorescent	fluorescent	JJ
cord-291727-4wfhuvww	197	12	ribosomes	ribosome	NNS
cord-291727-4wfhuvww	197	13	on	on	IN
cord-291727-4wfhuvww	197	14	immobilized	immobilize	VBN
cord-291727-4wfhuvww	197	15	RNA	RNA	NNP
cord-291727-4wfhuvww	197	16	sequences	sequence	NNS
cord-291727-4wfhuvww	197	17	and	and	CC
cord-291727-4wfhuvww	197	18	predicted	predict	VBD
cord-291727-4wfhuvww	197	19	the	the	DT
cord-291727-4wfhuvww	197	20	slipperiness	slipperiness	NN
cord-291727-4wfhuvww	197	21	of	of	IN
cord-291727-4wfhuvww	197	22	various	various	JJ
cord-291727-4wfhuvww	197	23	RNA	RNA	NNP
cord-291727-4wfhuvww	197	24	sequences	sequence	NNS
cord-291727-4wfhuvww	197	25	.	.	.
cord-291727-4wfhuvww	198	1	Again	again	RB
cord-291727-4wfhuvww	198	2	,	,	,
cord-291727-4wfhuvww	198	3	this	this	DT
cord-291727-4wfhuvww	198	4	will	will	MD
cord-291727-4wfhuvww	198	5	be	be	VB
cord-291727-4wfhuvww	198	6	technically	technically	RB
cord-291727-4wfhuvww	198	7	difficult	difficult	JJ
cord-291727-4wfhuvww	198	8	to	to	TO
cord-291727-4wfhuvww	198	9	implement	implement	VB
cord-291727-4wfhuvww	198	10	on	on	IN
cord-291727-4wfhuvww	198	11	a	a	DT
cord-291727-4wfhuvww	198	12	genome	genome	NN
cord-291727-4wfhuvww	198	13	-	-	HYPH
cord-291727-4wfhuvww	198	14	wide	wide	JJ
cord-291727-4wfhuvww	198	15	scale	scale	NN
cord-291727-4wfhuvww	198	16	.	.	.
cord-291727-4wfhuvww	199	1	All	all	DT
cord-291727-4wfhuvww	199	2	of	of	IN
cord-291727-4wfhuvww	199	3	the	the	DT
cord-291727-4wfhuvww	199	4	above	above	JJ
cord-291727-4wfhuvww	199	5	methods	method	NNS
cord-291727-4wfhuvww	199	6	will	will	MD
cord-291727-4wfhuvww	199	7	record	record	VB
cord-291727-4wfhuvww	199	8	mostly	mostly	RB
cord-291727-4wfhuvww	199	9	frameshifting	frameshifting	JJ
cord-291727-4wfhuvww	199	10	events	event	NNS
cord-291727-4wfhuvww	199	11	,	,	,
cord-291727-4wfhuvww	199	12	but	but	CC
cord-291727-4wfhuvww	199	13	they	-PRON-	PRP
cord-291727-4wfhuvww	199	14	will	will	MD
cord-291727-4wfhuvww	199	15	not	not	RB
cord-291727-4wfhuvww	199	16	validate	validate	VB
cord-291727-4wfhuvww	199	17	the	the	DT
cord-291727-4wfhuvww	199	18	expression	expression	NN
cord-291727-4wfhuvww	199	19	of	of	IN
cord-291727-4wfhuvww	199	20	an	an	DT
cord-291727-4wfhuvww	199	21	out	out	JJ
cord-291727-4wfhuvww	199	22	-	-	HYPH
cord-291727-4wfhuvww	199	23	offrame	offrame	NN
cord-291727-4wfhuvww	199	24	protein	protein	NN
cord-291727-4wfhuvww	199	25	.	.	.
cord-291727-4wfhuvww	200	1	It	-PRON-	PRP
cord-291727-4wfhuvww	200	2	is	be	VBZ
cord-291727-4wfhuvww	200	3	worth	worth	JJ
cord-291727-4wfhuvww	200	4	noting	note	VBG
cord-291727-4wfhuvww	200	5	that	that	IN
cord-291727-4wfhuvww	200	6	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	200	7	will	will	MD
cord-291727-4wfhuvww	200	8	most	most	RBS
cord-291727-4wfhuvww	200	9	likely	likely	RB
cord-291727-4wfhuvww	200	10	result	result	VB
cord-291727-4wfhuvww	200	11	in	in	IN
cord-291727-4wfhuvww	200	12	chimeric	chimeric	JJ
cord-291727-4wfhuvww	200	13	sequences	sequence	NNS
cord-291727-4wfhuvww	200	14	composed	compose	VBN
cord-291727-4wfhuvww	200	15	of	of	IN
cord-291727-4wfhuvww	200	16	a	a	DT
cord-291727-4wfhuvww	200	17	stretch	stretch	NN
cord-291727-4wfhuvww	200	18	of	of	IN
cord-291727-4wfhuvww	200	19	zero	zero	CD
cord-291727-4wfhuvww	200	20	frame	frame	NN
cord-291727-4wfhuvww	200	21	peptides	peptide	NNS
cord-291727-4wfhuvww	200	22	linked	link	VBN
cord-291727-4wfhuvww	200	23	to	to	IN
cord-291727-4wfhuvww	200	24	out	out	IN
cord-291727-4wfhuvww	200	25	-	-	HYPH
cord-291727-4wfhuvww	200	26	of	of	IN
cord-291727-4wfhuvww	200	27	-	-	HYPH
cord-291727-4wfhuvww	200	28	frame	frame	NN
cord-291727-4wfhuvww	200	29	peptides	peptide	NNS
cord-291727-4wfhuvww	200	30	,	,	,
cord-291727-4wfhuvww	200	31	which	which	WDT
cord-291727-4wfhuvww	200	32	can	can	MD
cord-291727-4wfhuvww	200	33	be	be	VB
cord-291727-4wfhuvww	200	34	a	a	DT
cord-291727-4wfhuvww	200	35	small	small	JJ
cord-291727-4wfhuvww	200	36	or	or	CC
cord-291727-4wfhuvww	200	37	large	large	JJ
cord-291727-4wfhuvww	200	38	part	part	NN
cord-291727-4wfhuvww	200	39	of	of	IN
cord-291727-4wfhuvww	200	40	the	the	DT
cord-291727-4wfhuvww	200	41	overall	overall	JJ
cord-291727-4wfhuvww	200	42	protein	protein	NN
cord-291727-4wfhuvww	200	43	,	,	,
cord-291727-4wfhuvww	200	44	depending	depend	VBG
cord-291727-4wfhuvww	200	45	on	on	IN
cord-291727-4wfhuvww	200	46	where	where	WRB
cord-291727-4wfhuvww	200	47	the	the	DT
cord-291727-4wfhuvww	200	48	frameshift	frameshift	NN
cord-291727-4wfhuvww	200	49	site	site	NN
cord-291727-4wfhuvww	200	50	is	be	VBZ
cord-291727-4wfhuvww	200	51	.	.	.
cord-291727-4wfhuvww	201	1	Alternatively	alternatively	RB
cord-291727-4wfhuvww	201	2	,	,	,
cord-291727-4wfhuvww	201	3	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	201	4	could	could	MD
cord-291727-4wfhuvww	201	5	lead	lead	VB
cord-291727-4wfhuvww	201	6	to	to	IN
cord-291727-4wfhuvww	201	7	truncation	truncation	NN
cord-291727-4wfhuvww	201	8	of	of	IN
cord-291727-4wfhuvww	201	9	the	the	DT
cord-291727-4wfhuvww	201	10	original	original	JJ
cord-291727-4wfhuvww	201	11	protein	protein	NN
cord-291727-4wfhuvww	201	12	,	,	,
cord-291727-4wfhuvww	201	13	where	where	WRB
cord-291727-4wfhuvww	201	14	a	a	DT
cord-291727-4wfhuvww	201	15	very	very	RB
cord-291727-4wfhuvww	201	16	small	small	JJ
cord-291727-4wfhuvww	201	17	fractionif	fractionif	NNS
cord-291727-4wfhuvww	201	18	any	any	DT
cord-291727-4wfhuvww	201	19	-	-	:
cord-291727-4wfhuvww	201	20	of	of	IN
cord-291727-4wfhuvww	201	21	the	the	DT
cord-291727-4wfhuvww	201	22	overall	overall	JJ
cord-291727-4wfhuvww	201	23	protein	protein	NN
cord-291727-4wfhuvww	201	24	is	be	VBZ
cord-291727-4wfhuvww	201	25	out	out	RB
cord-291727-4wfhuvww	201	26	-	-	HYPH
cord-291727-4wfhuvww	201	27	of	of	IN
cord-291727-4wfhuvww	201	28	-	-	HYPH
cord-291727-4wfhuvww	201	29	frame	frame	NN
cord-291727-4wfhuvww	201	30	(	(	-LRB-
cord-291727-4wfhuvww	201	31	Figure	figure	NN
cord-291727-4wfhuvww	201	32	4	4	CD
cord-291727-4wfhuvww	201	33	)	)	-RRB-
cord-291727-4wfhuvww	201	34	.	.	.
cord-291727-4wfhuvww	202	1	Those	those	DT
cord-291727-4wfhuvww	202	2	proteins	protein	NNS
cord-291727-4wfhuvww	202	3	that	that	WDT
cord-291727-4wfhuvww	202	4	have	have	VBP
cord-291727-4wfhuvww	202	5	a	a	DT
cord-291727-4wfhuvww	202	6	sufficient	sufficient	JJ
cord-291727-4wfhuvww	202	7	predicted	predict	VBN
cord-291727-4wfhuvww	202	8	length	length	NN
cord-291727-4wfhuvww	202	9	could	could	MD
cord-291727-4wfhuvww	202	10	then	then	RB
cord-291727-4wfhuvww	202	11	be	be	VB
cord-291727-4wfhuvww	202	12	validated	validate	VBN
cord-291727-4wfhuvww	202	13	by	by	IN
cord-291727-4wfhuvww	202	14	raising	raise	VBG
cord-291727-4wfhuvww	202	15	specific	specific	JJ
cord-291727-4wfhuvww	202	16	antibodies	antibody	NNS
cord-291727-4wfhuvww	202	17	against	against	IN
cord-291727-4wfhuvww	202	18	that	that	DT
cord-291727-4wfhuvww	202	19	sequence	sequence	NN
cord-291727-4wfhuvww	202	20	.	.	.
cord-291727-4wfhuvww	203	1	In	in	IN
cord-291727-4wfhuvww	203	2	order	order	NN
cord-291727-4wfhuvww	203	3	to	to	TO
cord-291727-4wfhuvww	203	4	raise	raise	VB
cord-291727-4wfhuvww	203	5	an	an	DT
cord-291727-4wfhuvww	203	6	antibody	antibody	NN
cord-291727-4wfhuvww	203	7	,	,	,
cord-291727-4wfhuvww	203	8	one	one	PRP
cord-291727-4wfhuvww	203	9	has	have	VBZ
cord-291727-4wfhuvww	203	10	to	to	TO
cord-291727-4wfhuvww	203	11	know	know	VB
cord-291727-4wfhuvww	203	12	the	the	DT
cord-291727-4wfhuvww	203	13	precise	precise	JJ
cord-291727-4wfhuvww	203	14	FIGURE	figure	NN
cord-291727-4wfhuvww	203	15	4	4	CD
cord-291727-4wfhuvww	203	16	|	|	NNP
cord-291727-4wfhuvww	203	17	Protein	Protein	NNP
cord-291727-4wfhuvww	203	18	composition	composition	NN
cord-291727-4wfhuvww	203	19	as	as	IN
cord-291727-4wfhuvww	203	20	a	a	DT
cord-291727-4wfhuvww	203	21	consequence	consequence	NN
cord-291727-4wfhuvww	203	22	of	of	IN
cord-291727-4wfhuvww	203	23	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	203	24	.	.	.
cord-291727-4wfhuvww	204	1	The	the	DT
cord-291727-4wfhuvww	204	2	original	original	JJ
cord-291727-4wfhuvww	204	3	zero	zero	CD
cord-291727-4wfhuvww	204	4	frame	frame	NN
cord-291727-4wfhuvww	204	5	is	be	VBZ
cord-291727-4wfhuvww	204	6	shown	show	VBN
cord-291727-4wfhuvww	204	7	in	in	IN
cord-291727-4wfhuvww	204	8	gray	gray	JJ
cord-291727-4wfhuvww	204	9	,	,	,
cord-291727-4wfhuvww	204	10	whereas	whereas	IN
cord-291727-4wfhuvww	204	11	out	out	RB
cord-291727-4wfhuvww	204	12	-	-	HYPH
cord-291727-4wfhuvww	204	13	of	of	IN
cord-291727-4wfhuvww	204	14	-	-	HYPH
cord-291727-4wfhuvww	204	15	frame	frame	NN
cord-291727-4wfhuvww	204	16	sequences	sequence	NNS
cord-291727-4wfhuvww	204	17	are	be	VBP
cord-291727-4wfhuvww	204	18	shown	show	VBN
cord-291727-4wfhuvww	204	19	in	in	IN
cord-291727-4wfhuvww	204	20	red	red	JJ
cord-291727-4wfhuvww	204	21	or	or	CC
cord-291727-4wfhuvww	204	22	blue	blue	JJ
cord-291727-4wfhuvww	204	23	colour	colour	NN
cord-291727-4wfhuvww	204	24	.	.	.
cord-291727-4wfhuvww	205	1	A	a	DT
cord-291727-4wfhuvww	205	2	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	205	3	event	event	NN
cord-291727-4wfhuvww	205	4	is	be	VBZ
cord-291727-4wfhuvww	205	5	marked	mark	VBN
cord-291727-4wfhuvww	205	6	by	by	IN
cord-291727-4wfhuvww	205	7	the	the	DT
cord-291727-4wfhuvww	205	8	arrow	arrow	NN
cord-291727-4wfhuvww	205	9	.	.	.
cord-291727-4wfhuvww	206	1	Frameshifting	Frameshifting	NNP
cord-291727-4wfhuvww	206	2	can	can	MD
cord-291727-4wfhuvww	206	3	result	result	VB
cord-291727-4wfhuvww	206	4	in	in	IN
cord-291727-4wfhuvww	206	5	chimeric	chimeric	JJ
cord-291727-4wfhuvww	206	6	peptides	peptide	NNS
cord-291727-4wfhuvww	206	7	composed	compose	VBN
cord-291727-4wfhuvww	206	8	of	of	IN
cord-291727-4wfhuvww	206	9	the	the	DT
cord-291727-4wfhuvww	206	10	original	original	JJ
cord-291727-4wfhuvww	206	11	frame	frame	NN
cord-291727-4wfhuvww	206	12	and	and	CC
cord-291727-4wfhuvww	206	13	out	out	IN
cord-291727-4wfhuvww	206	14	-	-	HYPH
cord-291727-4wfhuvww	206	15	of	of	IN
cord-291727-4wfhuvww	206	16	-	-	HYPH
cord-291727-4wfhuvww	206	17	frame	frame	NN
cord-291727-4wfhuvww	206	18	sequences	sequence	NNS
cord-291727-4wfhuvww	206	19	that	that	WDT
cord-291727-4wfhuvww	206	20	can	can	MD
cord-291727-4wfhuvww	206	21	form	form	VB
cord-291727-4wfhuvww	206	22	a	a	DT
cord-291727-4wfhuvww	206	23	small	small	JJ
cord-291727-4wfhuvww	206	24	or	or	CC
cord-291727-4wfhuvww	206	25	larger	large	JJR
cord-291727-4wfhuvww	206	26	part	part	NN
cord-291727-4wfhuvww	206	27	of	of	IN
cord-291727-4wfhuvww	206	28	the	the	DT
cord-291727-4wfhuvww	206	29	overall	overall	JJ
cord-291727-4wfhuvww	206	30	protein	protein	NN
cord-291727-4wfhuvww	206	31	,	,	,
cord-291727-4wfhuvww	206	32	depending	depend	VBG
cord-291727-4wfhuvww	206	33	on	on	IN
cord-291727-4wfhuvww	206	34	where	where	WRB
cord-291727-4wfhuvww	206	35	the	the	DT
cord-291727-4wfhuvww	206	36	frameshift	frameshift	NN
cord-291727-4wfhuvww	206	37	event	event	NN
cord-291727-4wfhuvww	206	38	takes	take	VBZ
cord-291727-4wfhuvww	206	39	place	place	NN
cord-291727-4wfhuvww	206	40	.	.	.
cord-291727-4wfhuvww	207	1	It	-PRON-	PRP
cord-291727-4wfhuvww	207	2	is	be	VBZ
cord-291727-4wfhuvww	207	3	also	also	RB
cord-291727-4wfhuvww	207	4	possible	possible	JJ
cord-291727-4wfhuvww	207	5	that	that	IN
cord-291727-4wfhuvww	207	6	more	more	JJR
cord-291727-4wfhuvww	207	7	than	than	IN
cord-291727-4wfhuvww	207	8	one	one	CD
cord-291727-4wfhuvww	207	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	207	10	event	event	NN
cord-291727-4wfhuvww	207	11	takes	take	VBZ
cord-291727-4wfhuvww	207	12	place	place	NN
cord-291727-4wfhuvww	207	13	within	within	IN
cord-291727-4wfhuvww	207	14	the	the	DT
cord-291727-4wfhuvww	207	15	same	same	JJ
cord-291727-4wfhuvww	207	16	mRNA	mrna	NN
cord-291727-4wfhuvww	207	17	,	,	,
cord-291727-4wfhuvww	207	18	thus	thus	RB
cord-291727-4wfhuvww	207	19	resulting	result	VBG
cord-291727-4wfhuvww	207	20	in	in	IN
cord-291727-4wfhuvww	207	21	mosaic	mosaic	JJ
cord-291727-4wfhuvww	207	22	hybrid	hybrid	JJ
cord-291727-4wfhuvww	207	23	peptide	peptide	NN
cord-291727-4wfhuvww	207	24	sequences	sequence	NNS
cord-291727-4wfhuvww	207	25	.	.	.
cord-291727-4wfhuvww	208	1	(	(	-LRB-
cord-291727-4wfhuvww	208	2	A	a	DT
cord-291727-4wfhuvww	208	3	,	,	,
cord-291727-4wfhuvww	208	4	Original	original	JJ
cord-291727-4wfhuvww	208	5	frame	frame	NN
cord-291727-4wfhuvww	208	6	;	;	:
cord-291727-4wfhuvww	208	7	B	b	NN
cord-291727-4wfhuvww	208	8	,	,	,
cord-291727-4wfhuvww	208	9	early	early	JJ
cord-291727-4wfhuvww	208	10	frameshift	frameshift	NN
cord-291727-4wfhuvww	208	11	with	with	IN
cord-291727-4wfhuvww	208	12	extended	extended	JJ
cord-291727-4wfhuvww	208	13	ORF	ORF	NNP
cord-291727-4wfhuvww	208	14	;	;	:
cord-291727-4wfhuvww	208	15	C	C	NNP
cord-291727-4wfhuvww	208	16	,	,	,
cord-291727-4wfhuvww	208	17	early	early	JJ
cord-291727-4wfhuvww	208	18	frameshift	frameshift	NN
cord-291727-4wfhuvww	208	19	with	with	IN
cord-291727-4wfhuvww	208	20	truncation	truncation	NN
cord-291727-4wfhuvww	208	21	;	;	:
cord-291727-4wfhuvww	208	22	D	d	JJ
cord-291727-4wfhuvww	208	23	,	,	,
cord-291727-4wfhuvww	208	24	late	late	JJ
cord-291727-4wfhuvww	208	25	frameshift	frameshift	NN
cord-291727-4wfhuvww	208	26	with	with	IN
cord-291727-4wfhuvww	208	27	extended	extended	JJ
cord-291727-4wfhuvww	208	28	ORF	ORF	NNP
cord-291727-4wfhuvww	208	29	;	;	:
cord-291727-4wfhuvww	208	30	E	E	NNP
cord-291727-4wfhuvww	208	31	,	,	,
cord-291727-4wfhuvww	208	32	two	two	CD
cord-291727-4wfhuvww	208	33	frameshift	frameshift	NN
cord-291727-4wfhuvww	208	34	events	event	NNS
cord-291727-4wfhuvww	208	35	that	that	WDT
cord-291727-4wfhuvww	208	36	switch	switch	VBP
cord-291727-4wfhuvww	208	37	back	back	RB
cord-291727-4wfhuvww	208	38	to	to	IN
cord-291727-4wfhuvww	208	39	the	the	DT
cord-291727-4wfhuvww	208	40	zero	zero	CD
cord-291727-4wfhuvww	208	41	frame	frame	NN
cord-291727-4wfhuvww	208	42	;	;	:
cord-291727-4wfhuvww	208	43	and	and	CC
cord-291727-4wfhuvww	208	44	F	F	NNP
cord-291727-4wfhuvww	208	45	,	,	,
cord-291727-4wfhuvww	208	46	two	two	CD
cord-291727-4wfhuvww	208	47	frameshift	frameshift	NN
cord-291727-4wfhuvww	208	48	events	event	NNS
cord-291727-4wfhuvww	208	49	that	that	WDT
cord-291727-4wfhuvww	208	50	produce	produce	VBP
cord-291727-4wfhuvww	208	51	a	a	DT
cord-291727-4wfhuvww	208	52	chimeric	chimeric	JJ
cord-291727-4wfhuvww	208	53	sequence	sequence	NN
cord-291727-4wfhuvww	208	54	of	of	IN
cord-291727-4wfhuvww	208	55	three	three	CD
cord-291727-4wfhuvww	208	56	different	different	JJ
cord-291727-4wfhuvww	208	57	frames	frame	NNS
cord-291727-4wfhuvww	208	58	.	.	.
cord-291727-4wfhuvww	208	59	)	)	-RRB-
cord-291727-4wfhuvww	209	1	sequence	sequence	NN
cord-291727-4wfhuvww	209	2	of	of	IN
cord-291727-4wfhuvww	209	3	the	the	DT
cord-291727-4wfhuvww	209	4	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	209	5	protein	protein	NN
cord-291727-4wfhuvww	209	6	.	.	.
cord-291727-4wfhuvww	210	1	Therefore	therefore	RB
cord-291727-4wfhuvww	210	2	,	,	,
cord-291727-4wfhuvww	210	3	this	this	DT
cord-291727-4wfhuvww	210	4	approach	approach	NN
cord-291727-4wfhuvww	210	5	is	be	VBZ
cord-291727-4wfhuvww	210	6	useful	useful	JJ
cord-291727-4wfhuvww	210	7	for	for	IN
cord-291727-4wfhuvww	210	8	confirming	confirm	VBG
cord-291727-4wfhuvww	210	9	a	a	DT
cord-291727-4wfhuvww	210	10	known	know	VBN
cord-291727-4wfhuvww	210	11	out	out	RB
cord-291727-4wfhuvww	210	12	-	-	HYPH
cord-291727-4wfhuvww	210	13	of	of	IN
cord-291727-4wfhuvww	210	14	-	-	HYPH
cord-291727-4wfhuvww	210	15	frame	frame	NN
cord-291727-4wfhuvww	210	16	protein	protein	NN
cord-291727-4wfhuvww	210	17	,	,	,
cord-291727-4wfhuvww	210	18	but	but	CC
cord-291727-4wfhuvww	210	19	it	-PRON-	PRP
cord-291727-4wfhuvww	210	20	is	be	VBZ
cord-291727-4wfhuvww	210	21	not	not	RB
cord-291727-4wfhuvww	210	22	amenable	amenable	JJ
cord-291727-4wfhuvww	210	23	to	to	IN
cord-291727-4wfhuvww	210	24	large	large	JJ
cord-291727-4wfhuvww	210	25	-	-	HYPH
cord-291727-4wfhuvww	210	26	scale	scale	NN
cord-291727-4wfhuvww	210	27	genome	genome	NN
cord-291727-4wfhuvww	210	28	-	-	HYPH
cord-291727-4wfhuvww	210	29	wide	wide	JJ
cord-291727-4wfhuvww	210	30	screening	screening	NN
cord-291727-4wfhuvww	210	31	.	.	.
cord-291727-4wfhuvww	211	1	In	in	IN
cord-291727-4wfhuvww	211	2	addition	addition	NN
cord-291727-4wfhuvww	211	3	,	,	,
cord-291727-4wfhuvww	211	4	the	the	DT
cord-291727-4wfhuvww	211	5	detection	detection	NN
cord-291727-4wfhuvww	211	6	of	of	IN
cord-291727-4wfhuvww	211	7	an	an	DT
cord-291727-4wfhuvww	211	8	endogenously	endogenously	RB
cord-291727-4wfhuvww	211	9	expressed	express	VBN
cord-291727-4wfhuvww	211	10	out	out	RB
cord-291727-4wfhuvww	211	11	-	-	HYPH
cord-291727-4wfhuvww	211	12	of	of	IN
cord-291727-4wfhuvww	211	13	-	-	HYPH
cord-291727-4wfhuvww	211	14	frame	frame	NN
cord-291727-4wfhuvww	211	15	protein	protein	NN
cord-291727-4wfhuvww	211	16	does	do	VBZ
cord-291727-4wfhuvww	211	17	not	not	RB
cord-291727-4wfhuvww	211	18	necessarily	necessarily	RB
cord-291727-4wfhuvww	211	19	indicate	indicate	VB
cord-291727-4wfhuvww	211	20	a	a	DT
cord-291727-4wfhuvww	211	21	functional	functional	JJ
cord-291727-4wfhuvww	211	22	relevance	relevance	NN
cord-291727-4wfhuvww	211	23	for	for	IN
cord-291727-4wfhuvww	211	24	this	this	DT
cord-291727-4wfhuvww	211	25	protein	protein	NN
cord-291727-4wfhuvww	211	26	.	.	.
cord-291727-4wfhuvww	212	1	In	in	IN
cord-291727-4wfhuvww	212	2	order	order	NN
cord-291727-4wfhuvww	212	3	to	to	TO
cord-291727-4wfhuvww	212	4	validate	validate	VB
cord-291727-4wfhuvww	212	5	a	a	DT
cord-291727-4wfhuvww	212	6	physiological	physiological	JJ
cord-291727-4wfhuvww	212	7	role	role	NN
cord-291727-4wfhuvww	212	8	for	for	IN
cord-291727-4wfhuvww	212	9	the	the	DT
cord-291727-4wfhuvww	212	10	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	212	11	gene	gene	NN
cord-291727-4wfhuvww	212	12	product	product	NN
cord-291727-4wfhuvww	212	13	,	,	,
cord-291727-4wfhuvww	212	14	the	the	DT
cord-291727-4wfhuvww	212	15	best	good	JJS
cord-291727-4wfhuvww	212	16	method	method	NN
cord-291727-4wfhuvww	212	17	is	be	VBZ
cord-291727-4wfhuvww	212	18	to	to	TO
cord-291727-4wfhuvww	212	19	genetically	genetically	RB
cord-291727-4wfhuvww	212	20	ablate	ablate	VB
cord-291727-4wfhuvww	212	21	the	the	DT
cord-291727-4wfhuvww	212	22	expression	expression	NN
cord-291727-4wfhuvww	212	23	of	of	IN
cord-291727-4wfhuvww	212	24	the	the	DT
cord-291727-4wfhuvww	212	25	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	212	26	protein	protein	NN
cord-291727-4wfhuvww	212	27	while	while	IN
cord-291727-4wfhuvww	212	28	preserving	preserve	VBG
cord-291727-4wfhuvww	212	29	the	the	DT
cord-291727-4wfhuvww	212	30	in	in	IN
cord-291727-4wfhuvww	212	31	-	-	HYPH
cord-291727-4wfhuvww	212	32	frame	frame	NN
cord-291727-4wfhuvww	212	33	sequence	sequence	NN
cord-291727-4wfhuvww	212	34	.	.	.
cord-291727-4wfhuvww	213	1	This	this	DT
cord-291727-4wfhuvww	213	2	can	can	MD
cord-291727-4wfhuvww	213	3	be	be	VB
cord-291727-4wfhuvww	213	4	accomplished	accomplish	VBN
cord-291727-4wfhuvww	213	5	by	by	IN
cord-291727-4wfhuvww	213	6	gene	gene	NN
cord-291727-4wfhuvww	213	7	targeting	target	VBG
cord-291727-4wfhuvww	213	8	with	with	IN
cord-291727-4wfhuvww	213	9	a	a	DT
cord-291727-4wfhuvww	213	10	gene	gene	NN
cord-291727-4wfhuvww	213	11	sequence	sequence	NN
cord-291727-4wfhuvww	213	12	that	that	WDT
cord-291727-4wfhuvww	213	13	harbours	harbour	VBZ
cord-291727-4wfhuvww	213	14	multiple	multiple	JJ
cord-291727-4wfhuvww	213	15	wobble	wobble	NN
cord-291727-4wfhuvww	213	16	base	base	NN
cord-291727-4wfhuvww	213	17	pair	pair	NN
cord-291727-4wfhuvww	213	18	mutations	mutation	NNS
cord-291727-4wfhuvww	213	19	or	or	CC
cord-291727-4wfhuvww	213	20	mutating	mutate	VBG
cord-291727-4wfhuvww	213	21	the	the	DT
cord-291727-4wfhuvww	213	22	frameshift	frameshift	NN
cord-291727-4wfhuvww	213	23	motif	motif	NN
cord-291727-4wfhuvww	213	24	,	,	,
cord-291727-4wfhuvww	213	25	thus	thus	RB
cord-291727-4wfhuvww	213	26	altering	alter	VBG
cord-291727-4wfhuvww	213	27	the	the	DT
cord-291727-4wfhuvww	213	28	RNA	RNA	NNP
cord-291727-4wfhuvww	213	29	sequence	sequence	NN
cord-291727-4wfhuvww	213	30	but	but	CC
cord-291727-4wfhuvww	213	31	not	not	RB
cord-291727-4wfhuvww	213	32	the	the	DT
cord-291727-4wfhuvww	213	33	in	in	IN
cord-291727-4wfhuvww	213	34	-	-	HYPH
cord-291727-4wfhuvww	213	35	frame	frame	NN
cord-291727-4wfhuvww	213	36	protein	protein	NN
cord-291727-4wfhuvww	213	37	sequence	sequence	NN
cord-291727-4wfhuvww	213	38	.	.	.
cord-291727-4wfhuvww	214	1	This	this	DT
cord-291727-4wfhuvww	214	2	is	be	VBZ
cord-291727-4wfhuvww	214	3	technically	technically	RB
cord-291727-4wfhuvww	214	4	challenging	challenging	JJ
cord-291727-4wfhuvww	214	5	and	and	CC
cord-291727-4wfhuvww	214	6	may	may	MD
cord-291727-4wfhuvww	214	7	not	not	RB
cord-291727-4wfhuvww	214	8	always	always	RB
cord-291727-4wfhuvww	214	9	be	be	VB
cord-291727-4wfhuvww	214	10	feasible	feasible	JJ
cord-291727-4wfhuvww	214	11	.	.	.
cord-291727-4wfhuvww	215	1	For	for	IN
cord-291727-4wfhuvww	215	2	instance	instance	NN
cord-291727-4wfhuvww	215	3	,	,	,
cord-291727-4wfhuvww	215	4	an	an	DT
cord-291727-4wfhuvww	215	5	OAZ3	OAZ3	NNP
cord-291727-4wfhuvww	215	6	knockout	knockout	NN
cord-291727-4wfhuvww	215	7	mouse	mouse	NN
cord-291727-4wfhuvww	215	8	model	model	NN
cord-291727-4wfhuvww	215	9	has	have	VBZ
cord-291727-4wfhuvww	215	10	been	be	VBN
cord-291727-4wfhuvww	215	11	generated	generate	VBN
cord-291727-4wfhuvww	215	12	,	,	,
cord-291727-4wfhuvww	215	13	where	where	WRB
cord-291727-4wfhuvww	215	14	both	both	CC
cord-291727-4wfhuvww	215	15	the	the	DT
cord-291727-4wfhuvww	215	16	zero	zero	CD
cord-291727-4wfhuvww	215	17	frame	frame	NN
cord-291727-4wfhuvww	215	18	and	and	CC
cord-291727-4wfhuvww	215	19	the	the	DT
cord-291727-4wfhuvww	215	20	+1	+1	HYPH
cord-291727-4wfhuvww	215	21	frame	frame	NN
cord-291727-4wfhuvww	215	22	has	have	VBZ
cord-291727-4wfhuvww	215	23	been	be	VBN
cord-291727-4wfhuvww	215	24	deleted	delete	VBN
cord-291727-4wfhuvww	216	1	(	(	-LRB-
cord-291727-4wfhuvww	216	2	Tokuhiro	Tokuhiro	NNP
cord-291727-4wfhuvww	216	3	et	et	NNP
cord-291727-4wfhuvww	216	4	al	al	NNP
cord-291727-4wfhuvww	216	5	.	.	NNP
cord-291727-4wfhuvww	216	6	,	,	,
cord-291727-4wfhuvww	216	7	2009	2009	CD
cord-291727-4wfhuvww	216	8	)	)	-RRB-
cord-291727-4wfhuvww	216	9	.	.	.
cord-291727-4wfhuvww	217	1	To	to	IN
cord-291727-4wfhuvww	217	2	my	-PRON-	PRP$
cord-291727-4wfhuvww	217	3	knowledge	knowledge	NN
cord-291727-4wfhuvww	217	4	,	,	,
cord-291727-4wfhuvww	217	5	no	no	DT
cord-291727-4wfhuvww	217	6	specific	specific	JJ
cord-291727-4wfhuvww	217	7	gene	gene	NN
cord-291727-4wfhuvww	217	8	targeting	target	VBG
cord-291727-4wfhuvww	217	9	of	of	IN
cord-291727-4wfhuvww	217	10	a	a	DT
cord-291727-4wfhuvww	217	11	frameshift	frameshift	NN
cord-291727-4wfhuvww	217	12	protein	protein	NN
cord-291727-4wfhuvww	217	13	has	have	VBZ
cord-291727-4wfhuvww	217	14	been	be	VBN
cord-291727-4wfhuvww	217	15	done	do	VBN
cord-291727-4wfhuvww	217	16	so	so	RB
cord-291727-4wfhuvww	217	17	far	far	RB
cord-291727-4wfhuvww	217	18	.	.	.
cord-291727-4wfhuvww	218	1	Genomic	genomic	JJ
cord-291727-4wfhuvww	218	2	methods	method	NNS
cord-291727-4wfhuvww	218	3	such	such	JJ
cord-291727-4wfhuvww	218	4	as	as	IN
cord-291727-4wfhuvww	218	5	RNA	RNA	NNP
cord-291727-4wfhuvww	218	6	sequencing	sequencing	NN
cord-291727-4wfhuvww	218	7	(	(	-LRB-
cord-291727-4wfhuvww	218	8	RNA	RNA	NNP
cord-291727-4wfhuvww	218	9	-	-	HYPH
cord-291727-4wfhuvww	218	10	seq	seq	NNP
cord-291727-4wfhuvww	218	11	)	)	-RRB-
cord-291727-4wfhuvww	218	12	have	have	VBP
cord-291727-4wfhuvww	218	13	emerged	emerge	VBN
cord-291727-4wfhuvww	218	14	as	as	IN
cord-291727-4wfhuvww	218	15	powerful	powerful	JJ
cord-291727-4wfhuvww	218	16	tools	tool	NNS
cord-291727-4wfhuvww	218	17	to	to	TO
cord-291727-4wfhuvww	218	18	profile	profile	VB
cord-291727-4wfhuvww	218	19	RNA	RNA	NNP
cord-291727-4wfhuvww	218	20	content	content	NN
cord-291727-4wfhuvww	218	21	in	in	IN
cord-291727-4wfhuvww	218	22	cells	cell	NNS
cord-291727-4wfhuvww	218	23	.	.	.
cord-291727-4wfhuvww	219	1	RNA	RNA	NNP
cord-291727-4wfhuvww	219	2	-	-	HYPH
cord-291727-4wfhuvww	219	3	seq	seq	NNP
cord-291727-4wfhuvww	219	4	is	be	VBZ
cord-291727-4wfhuvww	219	5	based	base	VBN
cord-291727-4wfhuvww	219	6	on	on	IN
cord-291727-4wfhuvww	219	7	high	high	JJ
cord-291727-4wfhuvww	219	8	-	-	HYPH
cord-291727-4wfhuvww	219	9	throughput	throughput	NN
cord-291727-4wfhuvww	219	10	sequencing	sequencing	NN
cord-291727-4wfhuvww	219	11	of	of	IN
cord-291727-4wfhuvww	219	12	a	a	DT
cord-291727-4wfhuvww	219	13	cDNA	cdna	NN
cord-291727-4wfhuvww	219	14	library	library	NN
cord-291727-4wfhuvww	219	15	generated	generate	VBN
cord-291727-4wfhuvww	219	16	from	from	IN
cord-291727-4wfhuvww	219	17	cellular	cellular	JJ
cord-291727-4wfhuvww	219	18	RNA	RNA	NNP
cord-291727-4wfhuvww	219	19	.	.	.
cord-291727-4wfhuvww	220	1	In	in	IN
cord-291727-4wfhuvww	220	2	its	-PRON-	PRP$
cord-291727-4wfhuvww	220	3	standard	standard	JJ
cord-291727-4wfhuvww	220	4	form	form	NN
cord-291727-4wfhuvww	220	5	,	,	,
cord-291727-4wfhuvww	220	6	RNAseq	RNAseq	NNP
cord-291727-4wfhuvww	220	7	enables	enable	VBZ
cord-291727-4wfhuvww	220	8	the	the	DT
cord-291727-4wfhuvww	220	9	identification	identification	NN
cord-291727-4wfhuvww	220	10	of	of	IN
cord-291727-4wfhuvww	220	11	indels	indel	NNS
cord-291727-4wfhuvww	220	12	,	,	,
cord-291727-4wfhuvww	220	13	but	but	CC
cord-291727-4wfhuvww	220	14	will	will	MD
cord-291727-4wfhuvww	220	15	fail	fail	VB
cord-291727-4wfhuvww	220	16	to	to	TO
cord-291727-4wfhuvww	220	17	identify	identify	VB
cord-291727-4wfhuvww	220	18	post	post	JJ
cord-291727-4wfhuvww	220	19	-	-	JJ
cord-291727-4wfhuvww	220	20	transcriptional	transcriptional	JJ
cord-291727-4wfhuvww	220	21	phenotypes	phenotype	NNS
cord-291727-4wfhuvww	220	22	and	and	CC
cord-291727-4wfhuvww	220	23	will	will	MD
cord-291727-4wfhuvww	220	24	therefore	therefore	RB
cord-291727-4wfhuvww	220	25	fail	fail	VB
cord-291727-4wfhuvww	220	26	to	to	TO
cord-291727-4wfhuvww	220	27	identify	identify	VB
cord-291727-4wfhuvww	220	28	programmed	program	VBN
cord-291727-4wfhuvww	220	29	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	220	30	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	220	31	or	or	CC
cord-291727-4wfhuvww	220	32	dual	dual	JJ
cord-291727-4wfhuvww	220	33	coded	code	VBN
cord-291727-4wfhuvww	220	34	genes	gene	NNS
cord-291727-4wfhuvww	220	35	.	.	.
cord-291727-4wfhuvww	221	1	Nevertheless	nevertheless	RB
cord-291727-4wfhuvww	221	2	,	,	,
cord-291727-4wfhuvww	221	3	ribosome	ribosome	NN
cord-291727-4wfhuvww	221	4	profiling	profiling	NN
cord-291727-4wfhuvww	221	5	methods	method	NNS
cord-291727-4wfhuvww	221	6	such	such	JJ
cord-291727-4wfhuvww	221	7	as	as	IN
cord-291727-4wfhuvww	221	8	Ribo	Ribo	NNP
cord-291727-4wfhuvww	221	9	-	-	HYPH
cord-291727-4wfhuvww	221	10	seq	seq	NNP
cord-291727-4wfhuvww	221	11	have	have	VBP
cord-291727-4wfhuvww	221	12	been	be	VBN
cord-291727-4wfhuvww	221	13	developed	develop	VBN
cord-291727-4wfhuvww	221	14	that	that	WDT
cord-291727-4wfhuvww	221	15	allow	allow	VB
cord-291727-4wfhuvww	221	16	the	the	DT
cord-291727-4wfhuvww	221	17	identification	identification	NN
cord-291727-4wfhuvww	221	18	of	of	IN
cord-291727-4wfhuvww	221	19	active	active	JJ
cord-291727-4wfhuvww	221	20	translation	translation	NN
cord-291727-4wfhuvww	221	21	,	,	,
cord-291727-4wfhuvww	221	22	based	base	VBN
cord-291727-4wfhuvww	221	23	on	on	IN
cord-291727-4wfhuvww	221	24	sequencing	sequencing	NN
cord-291727-4wfhuvww	221	25	of	of	IN
cord-291727-4wfhuvww	221	26	cDNA	cdna	NN
cord-291727-4wfhuvww	221	27	libraries	library	NNS
cord-291727-4wfhuvww	221	28	generated	generate	VBN
cord-291727-4wfhuvww	221	29	from	from	IN
cord-291727-4wfhuvww	221	30	ribosomeprotected	ribosomeprotected	JJ
cord-291727-4wfhuvww	221	31	fragments	fragment	NNS
cord-291727-4wfhuvww	221	32	(	(	-LRB-
cord-291727-4wfhuvww	221	33	Ingolia	Ingolia	NNP
cord-291727-4wfhuvww	221	34	et	et	NNP
cord-291727-4wfhuvww	221	35	al	al	NNP
cord-291727-4wfhuvww	221	36	.	.	NNP
cord-291727-4wfhuvww	221	37	,	,	,
cord-291727-4wfhuvww	221	38	2009	2009	CD
cord-291727-4wfhuvww	221	39	)	)	-RRB-
cord-291727-4wfhuvww	221	40	.	.	.
cord-291727-4wfhuvww	222	1	In	in	IN
cord-291727-4wfhuvww	222	2	this	this	DT
cord-291727-4wfhuvww	222	3	case	case	NN
cord-291727-4wfhuvww	222	4	,	,	,
cord-291727-4wfhuvww	222	5	mRNA	mrna	NN
cord-291727-4wfhuvww	222	6	bound	bind	VBN
cord-291727-4wfhuvww	222	7	to	to	IN
cord-291727-4wfhuvww	222	8	ribosomes	ribosome	NNS
cord-291727-4wfhuvww	222	9	is	be	VBZ
cord-291727-4wfhuvww	222	10	first	first	JJ
cord-291727-4wfhuvww	222	11	cross	cross	RB
cord-291727-4wfhuvww	222	12	-	-	VBN
cord-291727-4wfhuvww	222	13	linked	link	VBN
cord-291727-4wfhuvww	222	14	and	and	CC
cord-291727-4wfhuvww	222	15	then	then	RB
cord-291727-4wfhuvww	222	16	isolated	isolate	VBN
cord-291727-4wfhuvww	222	17	using	use	VBG
cord-291727-4wfhuvww	222	18	,	,	,
cord-291727-4wfhuvww	222	19	e.g.	e.g.	RB
cord-291727-4wfhuvww	222	20	,	,	,
cord-291727-4wfhuvww	222	21	sucrose	sucrose	NN
cord-291727-4wfhuvww	222	22	gradient	gradient	NN
cord-291727-4wfhuvww	222	23	density	density	NN
cord-291727-4wfhuvww	222	24	centrifugation	centrifugation	NN
cord-291727-4wfhuvww	222	25	.	.	.
cord-291727-4wfhuvww	223	1	Next	next	RB
cord-291727-4wfhuvww	223	2	,	,	,
cord-291727-4wfhuvww	223	3	a	a	DT
cord-291727-4wfhuvww	223	4	nuclease	nuclease	NN
cord-291727-4wfhuvww	223	5	digestion	digestion	NN
cord-291727-4wfhuvww	223	6	step	step	NN
cord-291727-4wfhuvww	223	7	results	result	NNS
cord-291727-4wfhuvww	223	8	in	in	IN
cord-291727-4wfhuvww	223	9	removal	removal	NN
cord-291727-4wfhuvww	223	10	of	of	IN
cord-291727-4wfhuvww	223	11	mRNA	mrna	NN
cord-291727-4wfhuvww	223	12	sequence	sequence	NN
cord-291727-4wfhuvww	223	13	that	that	WDT
cord-291727-4wfhuvww	223	14	is	be	VBZ
cord-291727-4wfhuvww	223	15	not	not	RB
cord-291727-4wfhuvww	223	16	bound	bind	VBN
cord-291727-4wfhuvww	223	17	(	(	-LRB-
cord-291727-4wfhuvww	223	18	"	"	``
cord-291727-4wfhuvww	223	19	protected	protect	VBN
cord-291727-4wfhuvww	223	20	"	"	''
cord-291727-4wfhuvww	223	21	)	)	-RRB-
cord-291727-4wfhuvww	223	22	to	to	TO
cord-291727-4wfhuvww	223	23	ribosomes	ribosome	NNS
cord-291727-4wfhuvww	223	24	.	.	.
cord-291727-4wfhuvww	224	1	The	the	DT
cord-291727-4wfhuvww	224	2	protected	protect	VBN
cord-291727-4wfhuvww	224	3	RNA	rna	NN
cord-291727-4wfhuvww	224	4	bound	bind	VBN
cord-291727-4wfhuvww	224	5	to	to	IN
cord-291727-4wfhuvww	224	6	ribosomes	ribosome	NNS
cord-291727-4wfhuvww	224	7	is	be	VBZ
cord-291727-4wfhuvww	224	8	then	then	RB
cord-291727-4wfhuvww	224	9	reverse	reverse	JJ
cord-291727-4wfhuvww	224	10	transcribed	transcribe	VBN
cord-291727-4wfhuvww	224	11	into	into	IN
cord-291727-4wfhuvww	224	12	cDNA	cdna	NN
cord-291727-4wfhuvww	224	13	and	and	CC
cord-291727-4wfhuvww	224	14	sequenced	sequence	VBN
cord-291727-4wfhuvww	224	15	.	.	.
cord-291727-4wfhuvww	225	1	Therefore	therefore	RB
cord-291727-4wfhuvww	225	2	,	,	,
cord-291727-4wfhuvww	225	3	the	the	DT
cord-291727-4wfhuvww	225	4	precise	precise	JJ
cord-291727-4wfhuvww	225	5	position	position	NN
cord-291727-4wfhuvww	225	6	of	of	IN
cord-291727-4wfhuvww	225	7	a	a	DT
cord-291727-4wfhuvww	225	8	ribosome	ribosome	NN
cord-291727-4wfhuvww	225	9	can	can	MD
cord-291727-4wfhuvww	225	10	be	be	VB
cord-291727-4wfhuvww	225	11	matched	match	VBN
cord-291727-4wfhuvww	225	12	to	to	IN
cord-291727-4wfhuvww	225	13	the	the	DT
cord-291727-4wfhuvww	225	14	site	site	NN
cord-291727-4wfhuvww	225	15	of	of	IN
cord-291727-4wfhuvww	225	16	active	active	JJ
cord-291727-4wfhuvww	225	17	translation	translation	NN
cord-291727-4wfhuvww	225	18	.	.	.
cord-291727-4wfhuvww	226	1	An	an	DT
cord-291727-4wfhuvww	226	2	adaptation	adaptation	NN
cord-291727-4wfhuvww	226	3	of	of	IN
cord-291727-4wfhuvww	226	4	this	this	DT
cord-291727-4wfhuvww	226	5	method	method	NN
cord-291727-4wfhuvww	226	6	using	use	VBG
cord-291727-4wfhuvww	226	7	the	the	DT
cord-291727-4wfhuvww	226	8	drug	drug	NN
cord-291727-4wfhuvww	226	9	harringtonine	harringtonine	NN
cord-291727-4wfhuvww	226	10	to	to	TO
cord-291727-4wfhuvww	226	11	cause	cause	VB
cord-291727-4wfhuvww	226	12	ribosome	ribosome	NN
cord-291727-4wfhuvww	226	13	accumulation	accumulation	NN
cord-291727-4wfhuvww	226	14	at	at	IN
cord-291727-4wfhuvww	226	15	initiation	initiation	NN
cord-291727-4wfhuvww	226	16	codons	codon	NNS
cord-291727-4wfhuvww	226	17	has	have	VBZ
cord-291727-4wfhuvww	226	18	allowed	allow	VBN
cord-291727-4wfhuvww	226	19	the	the	DT
cord-291727-4wfhuvww	226	20	identification	identification	NN
cord-291727-4wfhuvww	226	21	of	of	IN
cord-291727-4wfhuvww	226	22	translation	translation	NN
cord-291727-4wfhuvww	226	23	start	start	NN
cord-291727-4wfhuvww	226	24	sites	site	NNS
cord-291727-4wfhuvww	226	25	and	and	CC
cord-291727-4wfhuvww	226	26	confirmed	confirm	VBD
cord-291727-4wfhuvww	226	27	that	that	IN
cord-291727-4wfhuvww	226	28	many	many	JJ
cord-291727-4wfhuvww	226	29	proteins	protein	NNS
cord-291727-4wfhuvww	226	30	are	be	VBP
cord-291727-4wfhuvww	226	31	initiated	initiate	VBN
cord-291727-4wfhuvww	226	32	at	at	IN
cord-291727-4wfhuvww	226	33	non	non	NNP
cord-291727-4wfhuvww	226	34	-	-	JJ
cord-291727-4wfhuvww	226	35	AUG	AUG	NNP
cord-291727-4wfhuvww	226	36	or	or	CC
cord-291727-4wfhuvww	226	37	alternative	alternative	JJ
cord-291727-4wfhuvww	226	38	AUG	AUG	NNP
cord-291727-4wfhuvww	226	39	sites	site	NNS
cord-291727-4wfhuvww	227	1	(	(	-LRB-
cord-291727-4wfhuvww	227	2	Ingolia	Ingolia	NNP
cord-291727-4wfhuvww	227	3	et	et	NNP
cord-291727-4wfhuvww	227	4	al	al	NNP
cord-291727-4wfhuvww	227	5	.	.	NNP
cord-291727-4wfhuvww	227	6	,	,	,
cord-291727-4wfhuvww	227	7	2011	2011	CD
cord-291727-4wfhuvww	227	8	)	)	-RRB-
cord-291727-4wfhuvww	227	9	.	.	.
cord-291727-4wfhuvww	228	1	In	in	IN
cord-291727-4wfhuvww	228	2	this	this	DT
cord-291727-4wfhuvww	228	3	study	study	NN
cord-291727-4wfhuvww	228	4	,	,	,
cord-291727-4wfhuvww	228	5	44	44	CD
cord-291727-4wfhuvww	228	6	%	%	NN
cord-291727-4wfhuvww	228	7	of	of	IN
cord-291727-4wfhuvww	228	8	detected	detect	VBN
cord-291727-4wfhuvww	228	9	AUG	AUG	NNP
cord-291727-4wfhuvww	228	10	start	start	NN
cord-291727-4wfhuvww	228	11	sites	site	NNS
cord-291727-4wfhuvww	228	12	were	be	VBD
cord-291727-4wfhuvww	228	13	unannotated	unannotate	VBN
cord-291727-4wfhuvww	228	14	,	,	,
cord-291727-4wfhuvww	228	15	and	and	CC
cord-291727-4wfhuvww	228	16	a	a	DT
cord-291727-4wfhuvww	228	17	large	large	JJ
cord-291727-4wfhuvww	228	18	fraction	fraction	NN
cord-291727-4wfhuvww	228	19	of	of	IN
cord-291727-4wfhuvww	228	20	these	these	DT
cord-291727-4wfhuvww	228	21	encoded	encode	VBN
cord-291727-4wfhuvww	228	22	out	out	RB
cord-291727-4wfhuvww	228	23	-	-	HYPH
cord-291727-4wfhuvww	228	24	of	of	IN
cord-291727-4wfhuvww	228	25	-	-	HYPH
cord-291727-4wfhuvww	228	26	frame	frame	NN
cord-291727-4wfhuvww	228	27	peptides	peptide	NNS
cord-291727-4wfhuvww	228	28	.	.	.
cord-291727-4wfhuvww	229	1	Further	further	JJ
cord-291727-4wfhuvww	229	2	uses	use	NNS
cord-291727-4wfhuvww	229	3	of	of	IN
cord-291727-4wfhuvww	229	4	ribosome	ribosome	NN
cord-291727-4wfhuvww	229	5	profiling	profiling	NN
cord-291727-4wfhuvww	229	6	have	have	VBP
cord-291727-4wfhuvww	229	7	confirmed	confirm	VBN
cord-291727-4wfhuvww	229	8	that	that	IN
cord-291727-4wfhuvww	229	9	the	the	DT
cord-291727-4wfhuvww	229	10	identification	identification	NN
cord-291727-4wfhuvww	229	11	of	of	IN
cord-291727-4wfhuvww	229	12	frameshifts	frameshifts	NNP
cord-291727-4wfhuvww	229	13	is	be	VBZ
cord-291727-4wfhuvww	229	14	possible	possible	JJ
cord-291727-4wfhuvww	229	15	using	use	VBG
cord-291727-4wfhuvww	229	16	genomic	genomic	JJ
cord-291727-4wfhuvww	229	17	technologies	technology	NNS
cord-291727-4wfhuvww	229	18	(	(	-LRB-
cord-291727-4wfhuvww	229	19	Michel	Michel	NNP
cord-291727-4wfhuvww	229	20	et	et	NNP
cord-291727-4wfhuvww	229	21	al	al	NNP
cord-291727-4wfhuvww	229	22	.	.	NNP
cord-291727-4wfhuvww	229	23	,	,	,
cord-291727-4wfhuvww	229	24	2012	2012	CD
cord-291727-4wfhuvww	229	25	)	)	-RRB-
cord-291727-4wfhuvww	229	26	.	.	.
cord-291727-4wfhuvww	230	1	Although	although	IN
cord-291727-4wfhuvww	230	2	this	this	DT
cord-291727-4wfhuvww	230	3	approach	approach	NN
cord-291727-4wfhuvww	230	4	is	be	VBZ
cord-291727-4wfhuvww	230	5	unbiased	unbiased	JJ
cord-291727-4wfhuvww	230	6	in	in	IN
cord-291727-4wfhuvww	230	7	the	the	DT
cord-291727-4wfhuvww	230	8	sense	sense	NN
cord-291727-4wfhuvww	230	9	that	that	IN
cord-291727-4wfhuvww	230	10	it	-PRON-	PRP
cord-291727-4wfhuvww	230	11	does	do	VBZ
cord-291727-4wfhuvww	230	12	not	not	RB
cord-291727-4wfhuvww	230	13	pre	pre	VB
cord-291727-4wfhuvww	230	14	-	-	VB
cord-291727-4wfhuvww	230	15	filter	filter	VB
cord-291727-4wfhuvww	230	16	genetic	genetic	JJ
cord-291727-4wfhuvww	230	17	regions	region	NNS
cord-291727-4wfhuvww	230	18	,	,	,
cord-291727-4wfhuvww	230	19	one	one	CD
cord-291727-4wfhuvww	230	20	problem	problem	NN
cord-291727-4wfhuvww	230	21	is	be	VBZ
cord-291727-4wfhuvww	230	22	the	the	DT
cord-291727-4wfhuvww	230	23	nonuniformity	nonuniformity	NN
cord-291727-4wfhuvww	230	24	of	of	IN
cord-291727-4wfhuvww	230	25	ribosome	ribosome	NN
cord-291727-4wfhuvww	230	26	-	-	HYPH
cord-291727-4wfhuvww	230	27	protected	protect	VBN
cord-291727-4wfhuvww	230	28	fragment	fragment	NN
cord-291727-4wfhuvww	230	29	reads	read	VBZ
cord-291727-4wfhuvww	230	30	.	.	.
cord-291727-4wfhuvww	231	1	For	for	IN
cord-291727-4wfhuvww	231	2	instance	instance	NN
cord-291727-4wfhuvww	231	3	,	,	,
cord-291727-4wfhuvww	231	4	the	the	DT
cord-291727-4wfhuvww	231	5	preparation	preparation	NN
cord-291727-4wfhuvww	231	6	of	of	IN
cord-291727-4wfhuvww	231	7	cDNA	cdna	NN
cord-291727-4wfhuvww	231	8	libraries	library	NNS
cord-291727-4wfhuvww	231	9	generated	generate	VBN
cord-291727-4wfhuvww	231	10	from	from	IN
cord-291727-4wfhuvww	231	11	ribosomeprotected	ribosomeprotected	JJ
cord-291727-4wfhuvww	231	12	fragments	fragment	NNS
cord-291727-4wfhuvww	231	13	can	can	MD
cord-291727-4wfhuvww	231	14	result	result	VB
cord-291727-4wfhuvww	231	15	in	in	IN
cord-291727-4wfhuvww	231	16	over	over	IN
cord-291727-4wfhuvww	231	17	-	-	HYPH
cord-291727-4wfhuvww	231	18	or	or	CC
cord-291727-4wfhuvww	231	19	under	under	IN
cord-291727-4wfhuvww	231	20	-	-	HYPH
cord-291727-4wfhuvww	231	21	representation	representation	NN
cord-291727-4wfhuvww	231	22	of	of	IN
cord-291727-4wfhuvww	231	23	sequence	sequence	NN
cord-291727-4wfhuvww	231	24	reads	read	VBZ
cord-291727-4wfhuvww	231	25	.	.	.
cord-291727-4wfhuvww	232	1	This	this	DT
cord-291727-4wfhuvww	232	2	can	can	MD
cord-291727-4wfhuvww	232	3	be	be	VB
cord-291727-4wfhuvww	232	4	overcome	overcome	VBN
cord-291727-4wfhuvww	232	5	by	by	IN
cord-291727-4wfhuvww	232	6	a	a	DT
cord-291727-4wfhuvww	232	7	computational	computational	JJ
cord-291727-4wfhuvww	232	8	approach	approach	NN
cord-291727-4wfhuvww	232	9	that	that	WDT
cord-291727-4wfhuvww	232	10	measures	measure	VBZ
cord-291727-4wfhuvww	232	11	the	the	DT
cord-291727-4wfhuvww	232	12	cumulative	cumulative	JJ
cord-291727-4wfhuvww	232	13	subcodon	subcodon	NN
cord-291727-4wfhuvww	232	14	proportion	proportion	NN
cord-291727-4wfhuvww	232	15	difference	difference	NN
cord-291727-4wfhuvww	232	16	of	of	IN
cord-291727-4wfhuvww	232	17	ribosome	ribosome	NN
cord-291727-4wfhuvww	232	18	-	-	HYPH
cord-291727-4wfhuvww	232	19	protected	protect	VBN
cord-291727-4wfhuvww	232	20	fragments	fragment	NNS
cord-291727-4wfhuvww	232	21	relative	relative	JJ
cord-291727-4wfhuvww	232	22	to	to	IN
cord-291727-4wfhuvww	232	23	local	local	JJ
cord-291727-4wfhuvww	232	24	subcodon	subcodon	NN
cord-291727-4wfhuvww	232	25	positions	position	NNS
cord-291727-4wfhuvww	232	26	.	.	.
cord-291727-4wfhuvww	233	1	The	the	DT
cord-291727-4wfhuvww	233	2	authors	author	NNS
cord-291727-4wfhuvww	233	3	have	have	VBP
cord-291727-4wfhuvww	233	4	therefore	therefore	RB
cord-291727-4wfhuvww	233	5	combined	combine	VBN
cord-291727-4wfhuvww	233	6	experimental	experimental	JJ
cord-291727-4wfhuvww	233	7	data	datum	NNS
cord-291727-4wfhuvww	233	8	from	from	IN
cord-291727-4wfhuvww	233	9	Ribo	Ribo	NNP
cord-291727-4wfhuvww	233	10	-	-	HYPH
cord-291727-4wfhuvww	233	11	Seq	Seq	NNP
cord-291727-4wfhuvww	233	12	with	with	IN
cord-291727-4wfhuvww	233	13	a	a	DT
cord-291727-4wfhuvww	233	14	computational	computational	JJ
cord-291727-4wfhuvww	233	15	approach	approach	NN
cord-291727-4wfhuvww	233	16	in	in	IN
cord-291727-4wfhuvww	233	17	order	order	NN
cord-291727-4wfhuvww	233	18	to	to	TO
cord-291727-4wfhuvww	233	19	identify	identify	VB
cord-291727-4wfhuvww	233	20	novel	novel	JJ
cord-291727-4wfhuvww	233	21	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	233	22	protein	protein	NN
cord-291727-4wfhuvww	233	23	sequences	sequence	NNS
cord-291727-4wfhuvww	233	24	.	.	.
cord-291727-4wfhuvww	234	1	Using	use	VBG
cord-291727-4wfhuvww	234	2	this	this	DT
cord-291727-4wfhuvww	234	3	approach	approach	NN
cord-291727-4wfhuvww	234	4	,	,	,
cord-291727-4wfhuvww	234	5	several	several	JJ
cord-291727-4wfhuvww	234	6	new	new	JJ
cord-291727-4wfhuvww	234	7	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	234	8	protein	protein	NN
cord-291727-4wfhuvww	234	9	sequences	sequence	NNS
cord-291727-4wfhuvww	234	10	were	be	VBD
cord-291727-4wfhuvww	234	11	identified	identify	VBN
cord-291727-4wfhuvww	234	12	,	,	,
cord-291727-4wfhuvww	234	13	most	most	JJS
cord-291727-4wfhuvww	234	14	of	of	IN
cord-291727-4wfhuvww	234	15	which	which	WDT
cord-291727-4wfhuvww	234	16	were	be	VBD
cord-291727-4wfhuvww	234	17	dual	dual	RB
cord-291727-4wfhuvww	234	18	-	-	HYPH
cord-291727-4wfhuvww	234	19	encoded	encoded	JJ
cord-291727-4wfhuvww	234	20	.	.	.
cord-291727-4wfhuvww	235	1	The	the	DT
cord-291727-4wfhuvww	235	2	authors	author	NNS
cord-291727-4wfhuvww	235	3	estimate	estimate	VBP
cord-291727-4wfhuvww	235	4	that	that	IN
cord-291727-4wfhuvww	235	5	more	more	JJR
cord-291727-4wfhuvww	235	6	than	than	IN
cord-291727-4wfhuvww	235	7	1	1	CD
cord-291727-4wfhuvww	235	8	%	%	NN
cord-291727-4wfhuvww	235	9	of	of	IN
cord-291727-4wfhuvww	235	10	the	the	DT
cord-291727-4wfhuvww	235	11	genome	genome	NN
cord-291727-4wfhuvww	235	12	may	may	MD
cord-291727-4wfhuvww	235	13	consist	consist	VB
cord-291727-4wfhuvww	235	14	of	of	IN
cord-291727-4wfhuvww	235	15	dualcoding	dualcode	VBG
cord-291727-4wfhuvww	235	16	regions	region	NNS
cord-291727-4wfhuvww	235	17	,	,	,
cord-291727-4wfhuvww	235	18	and	and	CC
cord-291727-4wfhuvww	235	19	this	this	DT
cord-291727-4wfhuvww	235	20	is	be	VBZ
cord-291727-4wfhuvww	235	21	likely	likely	RB
cord-291727-4wfhuvww	235	22	an	an	DT
cord-291727-4wfhuvww	235	23	underestimation	underestimation	NN
cord-291727-4wfhuvww	235	24	.	.	.
cord-291727-4wfhuvww	236	1	Further	further	JJ
cord-291727-4wfhuvww	236	2	improvements	improvement	NNS
cord-291727-4wfhuvww	236	3	to	to	IN
cord-291727-4wfhuvww	236	4	the	the	DT
cord-291727-4wfhuvww	236	5	method	method	NN
cord-291727-4wfhuvww	236	6	,	,	,
cord-291727-4wfhuvww	236	7	including	include	VBG
cord-291727-4wfhuvww	236	8	deeper	deep	JJR
cord-291727-4wfhuvww	236	9	sequencing	sequencing	NN
cord-291727-4wfhuvww	236	10	to	to	TO
cord-291727-4wfhuvww	236	11	get	get	VB
cord-291727-4wfhuvww	236	12	better	well	JJR
cord-291727-4wfhuvww	236	13	coverage	coverage	NN
cord-291727-4wfhuvww	236	14	of	of	IN
cord-291727-4wfhuvww	236	15	ribosome	ribosome	NN
cord-291727-4wfhuvww	236	16	-	-	HYPH
cord-291727-4wfhuvww	236	17	protected	protect	VBN
cord-291727-4wfhuvww	236	18	fragments	fragment	NNS
cord-291727-4wfhuvww	236	19	,	,	,
cord-291727-4wfhuvww	236	20	will	will	MD
cord-291727-4wfhuvww	236	21	help	help	VB
cord-291727-4wfhuvww	236	22	to	to	TO
cord-291727-4wfhuvww	236	23	identify	identify	VB
cord-291727-4wfhuvww	236	24	these	these	DT
cord-291727-4wfhuvww	236	25	genes	gene	NNS
cord-291727-4wfhuvww	236	26	.	.	.
cord-291727-4wfhuvww	237	1	Most	Most	JJS
cord-291727-4wfhuvww	237	2	genome	genome	NN
cord-291727-4wfhuvww	237	3	-	-	HYPH
cord-291727-4wfhuvww	237	4	wide	wide	JJ
cord-291727-4wfhuvww	237	5	screening	screening	NN
cord-291727-4wfhuvww	237	6	approaches	approach	NNS
cord-291727-4wfhuvww	237	7	such	such	JJ
cord-291727-4wfhuvww	237	8	as	as	IN
cord-291727-4wfhuvww	237	9	RNAi	RNAi	NNP
cord-291727-4wfhuvww	237	10	-	-	HYPH
cord-291727-4wfhuvww	237	11	based	base	VBN
cord-291727-4wfhuvww	237	12	knockdown	knockdown	NN
cord-291727-4wfhuvww	237	13	methods	method	NNS
cord-291727-4wfhuvww	237	14	will	will	MD
cord-291727-4wfhuvww	237	15	fail	fail	VB
cord-291727-4wfhuvww	237	16	to	to	TO
cord-291727-4wfhuvww	237	17	identify	identify	VB
cord-291727-4wfhuvww	237	18	dual	dual	JJ
cord-291727-4wfhuvww	237	19	-	-	HYPH
cord-291727-4wfhuvww	237	20	coding	code	VBG
cord-291727-4wfhuvww	237	21	regions	region	NNS
cord-291727-4wfhuvww	237	22	,	,	,
cord-291727-4wfhuvww	237	23	as	as	IN
cord-291727-4wfhuvww	237	24	both	both	DT
cord-291727-4wfhuvww	237	25	gene	gene	NN
cord-291727-4wfhuvww	237	26	products	product	NNS
cord-291727-4wfhuvww	237	27	will	will	MD
cord-291727-4wfhuvww	237	28	be	be	VB
cord-291727-4wfhuvww	237	29	deleted	delete	VBN
cord-291727-4wfhuvww	237	30	.	.	.
cord-291727-4wfhuvww	238	1	Further	further	RB
cord-291727-4wfhuvww	238	2	,	,	,
cord-291727-4wfhuvww	238	3	most	most	RBS
cord-291727-4wfhuvww	238	4	commonly	commonly	RB
cord-291727-4wfhuvww	238	5	used	use	VBN
cord-291727-4wfhuvww	238	6	cDNA	cdna	NN
cord-291727-4wfhuvww	238	7	libraries	library	NNS
cord-291727-4wfhuvww	238	8	such	such	JJ
cord-291727-4wfhuvww	238	9	as	as	IN
cord-291727-4wfhuvww	238	10	the	the	DT
cord-291727-4wfhuvww	238	11	ORFeome	ORFeome	NNP
cord-291727-4wfhuvww	238	12	are	be	VBP
cord-291727-4wfhuvww	238	13	designed	design	VBN
cord-291727-4wfhuvww	238	14	to	to	TO
cord-291727-4wfhuvww	238	15	avoid	avoid	VB
cord-291727-4wfhuvww	238	16	expression	expression	NN
cord-291727-4wfhuvww	238	17	of	of	IN
cord-291727-4wfhuvww	238	18	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	238	19	peptides	peptide	NNS
cord-291727-4wfhuvww	238	20	-	-	,
cord-291727-4wfhuvww	238	21	for	for	IN
cord-291727-4wfhuvww	238	22	instance	instance	NN
cord-291727-4wfhuvww	238	23	,	,	,
cord-291727-4wfhuvww	238	24	by	by	IN
cord-291727-4wfhuvww	238	25	deletion	deletion	NN
cord-291727-4wfhuvww	238	26	of	of	IN
cord-291727-4wfhuvww	238	27	the	the	DT
cord-291727-4wfhuvww	238	28	5	5	CD
cord-291727-4wfhuvww	238	29	and	and	CC
cord-291727-4wfhuvww	238	30	3	3	CD
cord-291727-4wfhuvww	238	31	-UTR	-utr	NN
cord-291727-4wfhuvww	238	32	.	.	.
cord-291727-4wfhuvww	239	1	It	-PRON-	PRP
cord-291727-4wfhuvww	239	2	may	may	MD
cord-291727-4wfhuvww	239	3	,	,	,
cord-291727-4wfhuvww	239	4	however	however	RB
cord-291727-4wfhuvww	239	5	,	,	,
cord-291727-4wfhuvww	239	6	be	be	VB
cord-291727-4wfhuvww	239	7	possible	possible	JJ
cord-291727-4wfhuvww	239	8	that	that	IN
cord-291727-4wfhuvww	239	9	certain	certain	JJ
cord-291727-4wfhuvww	239	10	phenotypes	phenotype	NNS
cord-291727-4wfhuvww	239	11	in	in	IN
cord-291727-4wfhuvww	239	12	cDNA	cdna	NN
cord-291727-4wfhuvww	239	13	screening	screening	NN
cord-291727-4wfhuvww	239	14	are	be	VBP
cord-291727-4wfhuvww	239	15	exerted	exert	VBN
cord-291727-4wfhuvww	239	16	by	by	IN
cord-291727-4wfhuvww	239	17	out	out	IN
cord-291727-4wfhuvww	239	18	-	-	HYPH
cord-291727-4wfhuvww	239	19	of	of	IN
cord-291727-4wfhuvww	239	20	-	-	HYPH
cord-291727-4wfhuvww	239	21	frame	frame	NN
cord-291727-4wfhuvww	239	22	proteins	protein	NNS
cord-291727-4wfhuvww	239	23	.	.	.
cord-291727-4wfhuvww	240	1	In	in	IN
cord-291727-4wfhuvww	240	2	order	order	NN
cord-291727-4wfhuvww	240	3	to	to	TO
cord-291727-4wfhuvww	240	4	fish	fish	VB
cord-291727-4wfhuvww	240	5	for	for	IN
cord-291727-4wfhuvww	240	6	phenotypic	phenotypic	JJ
cord-291727-4wfhuvww	240	7	effects	effect	NNS
cord-291727-4wfhuvww	240	8	exerted	exert	VBN
cord-291727-4wfhuvww	240	9	by	by	IN
cord-291727-4wfhuvww	240	10	such	such	JJ
cord-291727-4wfhuvww	240	11	peptides	peptide	NNS
cord-291727-4wfhuvww	240	12	,	,	,
cord-291727-4wfhuvww	240	13	cDNA	cdna	NN
cord-291727-4wfhuvww	240	14	libraries	library	NNS
cord-291727-4wfhuvww	240	15	can	can	MD
cord-291727-4wfhuvww	240	16	be	be	VB
cord-291727-4wfhuvww	240	17	designed	design	VBN
cord-291727-4wfhuvww	240	18	in	in	IN
cord-291727-4wfhuvww	240	19	a	a	DT
cord-291727-4wfhuvww	240	20	way	way	NN
cord-291727-4wfhuvww	240	21	that	that	IN
cord-291727-4wfhuvww	240	22	genomic	genomic	JJ
cord-291727-4wfhuvww	240	23	fragments	fragment	NNS
cord-291727-4wfhuvww	240	24	are	be	VBP
cord-291727-4wfhuvww	240	25	inserted	insert	VBN
cord-291727-4wfhuvww	240	26	downstream	downstream	RB
cord-291727-4wfhuvww	240	27	of	of	IN
cord-291727-4wfhuvww	240	28	an	an	DT
cord-291727-4wfhuvww	240	29	AUG	AUG	NNP
cord-291727-4wfhuvww	240	30	start	start	NN
cord-291727-4wfhuvww	240	31	codon	codon	NN
cord-291727-4wfhuvww	240	32	in	in	IN
cord-291727-4wfhuvww	240	33	+1	+1	HYPH
cord-291727-4wfhuvww	240	34	or	or	CC
cord-291727-4wfhuvww	240	35	−1	−1	NNP
cord-291727-4wfhuvww	240	36	frame	frame	NN
cord-291727-4wfhuvww	240	37	so	so	IN
cord-291727-4wfhuvww	240	38	that	that	IN
cord-291727-4wfhuvww	240	39	all	all	DT
cord-291727-4wfhuvww	240	40	genomic	genomic	JJ
cord-291727-4wfhuvww	240	41	fragments	fragment	NNS
cord-291727-4wfhuvww	240	42	are	be	VBP
cord-291727-4wfhuvww	240	43	deliberately	deliberately	RB
cord-291727-4wfhuvww	240	44	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	240	45	.	.	.
cord-291727-4wfhuvww	241	1	A	a	DT
cord-291727-4wfhuvww	241	2	subsequent	subsequent	JJ
cord-291727-4wfhuvww	241	3	functional	functional	JJ
cord-291727-4wfhuvww	241	4	phenotypic	phenotypic	NN
cord-291727-4wfhuvww	241	5	screen	screen	NN
cord-291727-4wfhuvww	241	6	can	can	MD
cord-291727-4wfhuvww	241	7	then	then	RB
cord-291727-4wfhuvww	241	8	identify	identify	VB
cord-291727-4wfhuvww	241	9	phenotypes	phenotype	NNS
cord-291727-4wfhuvww	241	10	associated	associate	VBN
cord-291727-4wfhuvww	241	11	with	with	IN
cord-291727-4wfhuvww	241	12	expression	expression	NN
cord-291727-4wfhuvww	241	13	of	of	IN
cord-291727-4wfhuvww	241	14	such	such	JJ
cord-291727-4wfhuvww	241	15	deliberate	deliberate	JJ
cord-291727-4wfhuvww	241	16	frameshift	frameshift	NN
cord-291727-4wfhuvww	241	17	fragments	fragment	NNS
cord-291727-4wfhuvww	241	18	.	.	.
cord-291727-4wfhuvww	242	1	However	however	RB
cord-291727-4wfhuvww	242	2	,	,	,
cord-291727-4wfhuvww	242	3	there	there	EX
cord-291727-4wfhuvww	242	4	are	be	VBP
cord-291727-4wfhuvww	242	5	limitations	limitation	NNS
cord-291727-4wfhuvww	242	6	in	in	IN
cord-291727-4wfhuvww	242	7	such	such	PDT
cord-291727-4wfhuvww	242	8	an	an	DT
cord-291727-4wfhuvww	242	9	approach	approach	NN
cord-291727-4wfhuvww	242	10	,	,	,
cord-291727-4wfhuvww	242	11	e.g.	e.g.	RB
cord-291727-4wfhuvww	242	12	,	,	,
cord-291727-4wfhuvww	242	13	where	where	WRB
cord-291727-4wfhuvww	242	14	to	to	TO
cord-291727-4wfhuvww	242	15	place	place	VB
cord-291727-4wfhuvww	242	16	the	the	DT
cord-291727-4wfhuvww	242	17	frameshift	frameshift	NN
cord-291727-4wfhuvww	242	18	.	.	.
cord-291727-4wfhuvww	243	1	Also	also	RB
cord-291727-4wfhuvww	243	2	,	,	,
cord-291727-4wfhuvww	243	3	deliberately	deliberately	RB
cord-291727-4wfhuvww	243	4	expressed	express	VBD
cord-291727-4wfhuvww	243	5	out	out	RB
cord-291727-4wfhuvww	243	6	-	-	HYPH
cord-291727-4wfhuvww	243	7	of	of	IN
cord-291727-4wfhuvww	243	8	-	-	HYPH
cord-291727-4wfhuvww	243	9	frame	frame	NN
cord-291727-4wfhuvww	243	10	proteins	protein	NNS
cord-291727-4wfhuvww	243	11	may	may	MD
cord-291727-4wfhuvww	243	12	have	have	VB
cord-291727-4wfhuvww	243	13	little	little	JJ
cord-291727-4wfhuvww	243	14	physiological	physiological	JJ
cord-291727-4wfhuvww	243	15	relevance	relevance	NN
cord-291727-4wfhuvww	243	16	.	.	.
cord-291727-4wfhuvww	244	1	An	an	DT
cord-291727-4wfhuvww	244	2	alternative	alternative	NN
cord-291727-4wfhuvww	244	3	may	may	MD
cord-291727-4wfhuvww	244	4	be	be	VB
cord-291727-4wfhuvww	244	5	to	to	TO
cord-291727-4wfhuvww	244	6	use	use	VB
cord-291727-4wfhuvww	244	7	agents	agent	NNS
cord-291727-4wfhuvww	244	8	such	such	JJ
cord-291727-4wfhuvww	244	9	as	as	IN
cord-291727-4wfhuvww	244	10	gentamicin	gentamicin	NNP
cord-291727-4wfhuvww	244	11	that	that	WDT
cord-291727-4wfhuvww	244	12	enhance	enhance	VBP
cord-291727-4wfhuvww	244	13	programmed	program	VBN
cord-291727-4wfhuvww	244	14	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	244	15	.	.	.
cord-291727-4wfhuvww	245	1	In	in	IN
cord-291727-4wfhuvww	245	2	that	that	DT
cord-291727-4wfhuvww	245	3	case	case	NN
cord-291727-4wfhuvww	245	4	,	,	,
cord-291727-4wfhuvww	245	5	cells	cell	NNS
cord-291727-4wfhuvww	245	6	expressing	express	VBG
cord-291727-4wfhuvww	245	7	a	a	DT
cord-291727-4wfhuvww	245	8	cDNA	cdna	NN
cord-291727-4wfhuvww	245	9	library	library	NN
cord-291727-4wfhuvww	245	10	would	would	MD
cord-291727-4wfhuvww	245	11	be	be	VB
cord-291727-4wfhuvww	245	12	treated	treat	VBN
cord-291727-4wfhuvww	245	13	with	with	IN
cord-291727-4wfhuvww	245	14	a	a	DT
cord-291727-4wfhuvww	245	15	frameshift	frameshift	NN
cord-291727-4wfhuvww	245	16	inducer	inducer	NN
cord-291727-4wfhuvww	245	17	,	,	,
cord-291727-4wfhuvww	245	18	and	and	CC
cord-291727-4wfhuvww	245	19	the	the	DT
cord-291727-4wfhuvww	245	20	occurrence	occurrence	NN
cord-291727-4wfhuvww	245	21	of	of	IN
cord-291727-4wfhuvww	245	22	differential	differential	JJ
cord-291727-4wfhuvww	245	23	phenotypes	phenotype	NNS
cord-291727-4wfhuvww	245	24	plus	plus	CC
cord-291727-4wfhuvww	245	25	/	/	SYM
cord-291727-4wfhuvww	245	26	minus	minus	CC
cord-291727-4wfhuvww	245	27	frameshift	frameshift	NN
cord-291727-4wfhuvww	245	28	inducer	inducer	NN
cord-291727-4wfhuvww	245	29	would	would	MD
cord-291727-4wfhuvww	245	30	be	be	VB
cord-291727-4wfhuvww	245	31	recorded	record	VBN
cord-291727-4wfhuvww	245	32	.	.	.
cord-291727-4wfhuvww	246	1	It	-PRON-	PRP
cord-291727-4wfhuvww	246	2	is	be	VBZ
cord-291727-4wfhuvww	246	3	imperative	imperative	JJ
cord-291727-4wfhuvww	246	4	that	that	IN
cord-291727-4wfhuvww	246	5	cDNA	cdna	NN
cord-291727-4wfhuvww	246	6	libraries	library	NNS
cord-291727-4wfhuvww	246	7	with	with	IN
cord-291727-4wfhuvww	246	8	3	3	CD
cord-291727-4wfhuvww	246	9	-UTR	-utr	NN
cord-291727-4wfhuvww	246	10	regions	region	NNS
cord-291727-4wfhuvww	246	11	are	be	VBP
cord-291727-4wfhuvww	246	12	used	use	VBN
cord-291727-4wfhuvww	246	13	in	in	IN
cord-291727-4wfhuvww	246	14	such	such	PDT
cord-291727-4wfhuvww	246	15	an	an	DT
cord-291727-4wfhuvww	246	16	approach	approach	NN
cord-291727-4wfhuvww	246	17	to	to	TO
cord-291727-4wfhuvww	246	18	facilitate	facilitate	VB
cord-291727-4wfhuvww	246	19	the	the	DT
cord-291727-4wfhuvww	246	20	out	out	RB
cord-291727-4wfhuvww	246	21	-	-	HYPH
cord-291727-4wfhuvww	246	22	of	of	IN
cord-291727-4wfhuvww	246	23	-	-	HYPH
cord-291727-4wfhuvww	246	24	frame	frame	NN
cord-291727-4wfhuvww	246	25	peptide	peptide	JJ
cord-291727-4wfhuvww	246	26	expression	expression	NN
cord-291727-4wfhuvww	246	27	after	after	IN
cord-291727-4wfhuvww	246	28	stop	stop	NN
cord-291727-4wfhuvww	246	29	codon	codon	NN
cord-291727-4wfhuvww	246	30	read	read	VBN
cord-291727-4wfhuvww	246	31	-	-	HYPH
cord-291727-4wfhuvww	246	32	through	through	NN
cord-291727-4wfhuvww	246	33	.	.	.
cord-291727-4wfhuvww	247	1	A	a	DT
cord-291727-4wfhuvww	247	2	similar	similar	JJ
cord-291727-4wfhuvww	247	3	approach	approach	NN
cord-291727-4wfhuvww	247	4	can	can	MD
cord-291727-4wfhuvww	247	5	be	be	VB
cord-291727-4wfhuvww	247	6	used	use	VBN
cord-291727-4wfhuvww	247	7	to	to	TO
cord-291727-4wfhuvww	247	8	identify	identify	VB
cord-291727-4wfhuvww	247	9	endogenous	endogenous	JJ
cord-291727-4wfhuvww	247	10	regulators	regulator	NNS
cord-291727-4wfhuvww	247	11	of	of	IN
cord-291727-4wfhuvww	247	12	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	247	13	.	.	.
cord-291727-4wfhuvww	248	1	One	one	PRP
cord-291727-4wfhuvww	248	2	could	could	MD
cord-291727-4wfhuvww	248	3	use	use	VB
cord-291727-4wfhuvww	248	4	the	the	DT
cord-291727-4wfhuvww	248	5	dual	dual	JJ
cord-291727-4wfhuvww	248	6	luciferase	luciferase	NN
cord-291727-4wfhuvww	248	7	reporter	reporter	NN
cord-291727-4wfhuvww	248	8	construct	construct	VB
cord-291727-4wfhuvww	248	9	(	(	-LRB-
cord-291727-4wfhuvww	248	10	Grentzmann	Grentzmann	NNP
cord-291727-4wfhuvww	248	11	et	et	FW
cord-291727-4wfhuvww	248	12	al	al	NNP
cord-291727-4wfhuvww	248	13	.	.	NNP
cord-291727-4wfhuvww	248	14	,	,	,
cord-291727-4wfhuvww	248	15	1998	1998	CD
cord-291727-4wfhuvww	248	16	)	)	-RRB-
cord-291727-4wfhuvww	248	17	with	with	IN
cord-291727-4wfhuvww	248	18	a	a	DT
cord-291727-4wfhuvww	248	19	known	know	VBN
cord-291727-4wfhuvww	248	20	frameshift	frameshift	NN
cord-291727-4wfhuvww	248	21	motif	motif	NN
cord-291727-4wfhuvww	248	22	and	and	CC
cord-291727-4wfhuvww	248	23	screen	screen	NN
cord-291727-4wfhuvww	248	24	siRNA	siRNA	NNP
cord-291727-4wfhuvww	248	25	or	or	CC
cord-291727-4wfhuvww	248	26	cDNA	cdna	NN
cord-291727-4wfhuvww	248	27	libraries	library	NNS
cord-291727-4wfhuvww	248	28	to	to	TO
cord-291727-4wfhuvww	248	29	identify	identify	VB
cord-291727-4wfhuvww	248	30	genes	gene	NNS
cord-291727-4wfhuvww	248	31	that	that	WDT
cord-291727-4wfhuvww	248	32	enhance	enhance	VBP
cord-291727-4wfhuvww	248	33	or	or	CC
cord-291727-4wfhuvww	248	34	inhibit	inhibit	VB
cord-291727-4wfhuvww	248	35	the	the	DT
cord-291727-4wfhuvww	248	36	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	248	37	efficiency	efficiency	NN
cord-291727-4wfhuvww	248	38	of	of	IN
cord-291727-4wfhuvww	248	39	this	this	DT
cord-291727-4wfhuvww	248	40	reporter	reporter	NN
cord-291727-4wfhuvww	248	41	.	.	.
cord-291727-4wfhuvww	249	1	The	the	DT
cord-291727-4wfhuvww	249	2	existence	existence	NN
cord-291727-4wfhuvww	249	3	of	of	IN
cord-291727-4wfhuvww	249	4	non	non	JJ
cord-291727-4wfhuvww	249	5	-	-	JJ
cord-291727-4wfhuvww	249	6	coding	coding	JJ
cord-291727-4wfhuvww	249	7	RNAs	rna	NNS
cord-291727-4wfhuvww	249	8	that	that	WDT
cord-291727-4wfhuvww	249	9	modulate	modulate	VBP
cord-291727-4wfhuvww	249	10	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	249	11	suggests	suggest	VBZ
cord-291727-4wfhuvww	249	12	that	that	IN
cord-291727-4wfhuvww	249	13	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	249	14	is	be	VBZ
cord-291727-4wfhuvww	249	15	regulated	regulate	VBN
cord-291727-4wfhuvww	249	16	by	by	IN
cord-291727-4wfhuvww	249	17	endogenous	endogenous	JJ
cord-291727-4wfhuvww	249	18	gene	gene	NN
cord-291727-4wfhuvww	249	19	products	product	NNS
cord-291727-4wfhuvww	249	20	.	.	.
cord-291727-4wfhuvww	250	1	The	the	DT
cord-291727-4wfhuvww	250	2	dual	dual	JJ
cord-291727-4wfhuvww	250	3	luciferase	luciferase	NN
cord-291727-4wfhuvww	250	4	reporter	reporter	NN
cord-291727-4wfhuvww	250	5	mentioned	mention	VBN
cord-291727-4wfhuvww	250	6	above	above	RB
cord-291727-4wfhuvww	250	7	can	can	MD
cord-291727-4wfhuvww	250	8	also	also	RB
cord-291727-4wfhuvww	250	9	be	be	VB
cord-291727-4wfhuvww	250	10	used	use	VBN
cord-291727-4wfhuvww	250	11	to	to	TO
cord-291727-4wfhuvww	250	12	probe	probe	VB
cord-291727-4wfhuvww	250	13	the	the	DT
cord-291727-4wfhuvww	250	14	sequence	sequence	NN
cord-291727-4wfhuvww	250	15	space	space	NN
cord-291727-4wfhuvww	250	16	for	for	IN
cord-291727-4wfhuvww	250	17	optimal	optimal	JJ
cord-291727-4wfhuvww	250	18	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	250	19	motifs	motif	NNS
cord-291727-4wfhuvww	251	1	(	(	-LRB-
cord-291727-4wfhuvww	251	2	Rakauskaite	Rakauskaite	NNP
cord-291727-4wfhuvww	251	3	et	et	NNP
cord-291727-4wfhuvww	251	4	al	al	NNP
cord-291727-4wfhuvww	251	5	.	.	NNP
cord-291727-4wfhuvww	251	6	,	,	,
cord-291727-4wfhuvww	251	7	2011	2011	CD
cord-291727-4wfhuvww	251	8	)	)	-RRB-
cord-291727-4wfhuvww	251	9	.	.	.
cord-291727-4wfhuvww	252	1	Recently	recently	RB
cord-291727-4wfhuvww	252	2	,	,	,
cord-291727-4wfhuvww	252	3	an	an	DT
cord-291727-4wfhuvww	252	4	adaptation	adaptation	NN
cord-291727-4wfhuvww	252	5	of	of	IN
cord-291727-4wfhuvww	252	6	this	this	DT
cord-291727-4wfhuvww	252	7	approach	approach	NN
cord-291727-4wfhuvww	252	8	has	have	VBZ
cord-291727-4wfhuvww	252	9	been	be	VBN
cord-291727-4wfhuvww	252	10	developed	develop	VBN
cord-291727-4wfhuvww	252	11	using	use	VBG
cord-291727-4wfhuvww	252	12	fluorophores	fluorophore	NNS
cord-291727-4wfhuvww	252	13	that	that	WDT
cord-291727-4wfhuvww	252	14	are	be	VBP
cord-291727-4wfhuvww	252	15	amenable	amenable	JJ
cord-291727-4wfhuvww	252	16	to	to	IN
cord-291727-4wfhuvww	252	17	high	high	JJ
cord-291727-4wfhuvww	252	18	-	-	HYPH
cord-291727-4wfhuvww	252	19	throughput	throughput	NN
cord-291727-4wfhuvww	252	20	screening	screening	NN
cord-291727-4wfhuvww	252	21	applications	application	NNS
cord-291727-4wfhuvww	252	22	(	(	-LRB-
cord-291727-4wfhuvww	252	23	Cardno	Cardno	NNP
cord-291727-4wfhuvww	252	24	et	et	FW
cord-291727-4wfhuvww	252	25	al	al	NNP
cord-291727-4wfhuvww	252	26	.	.	NNP
cord-291727-4wfhuvww	252	27	,	,	,
cord-291727-4wfhuvww	252	28	2009	2009	CD
cord-291727-4wfhuvww	252	29	)	)	-RRB-
cord-291727-4wfhuvww	252	30	.	.	.
cord-291727-4wfhuvww	253	1	An	an	DT
cord-291727-4wfhuvww	253	2	in	in	IN
cord-291727-4wfhuvww	253	3	vivo	vivo	NN
cord-291727-4wfhuvww	253	4	adaptation	adaptation	NN
cord-291727-4wfhuvww	253	5	for	for	IN
cord-291727-4wfhuvww	253	6	yeast	yeast	NN
cord-291727-4wfhuvww	253	7	cells	cell	NNS
cord-291727-4wfhuvww	253	8	has	have	VBZ
cord-291727-4wfhuvww	253	9	been	be	VBN
cord-291727-4wfhuvww	253	10	proposed	propose	VBN
cord-291727-4wfhuvww	253	11	for	for	IN
cord-291727-4wfhuvww	253	12	use	use	NN
cord-291727-4wfhuvww	253	13	in	in	IN
cord-291727-4wfhuvww	253	14	high	high	JJ
cord-291727-4wfhuvww	253	15	-	-	HYPH
cord-291727-4wfhuvww	253	16	throughput	throughput	NN
cord-291727-4wfhuvww	253	17	screening	screening	NN
cord-291727-4wfhuvww	253	18	experiments	experiment	NNS
cord-291727-4wfhuvww	253	19	(	(	-LRB-
cord-291727-4wfhuvww	253	20	Harger	Harger	NNP
cord-291727-4wfhuvww	253	21	and	and	CC
cord-291727-4wfhuvww	253	22	Dinman	Dinman	NNP
cord-291727-4wfhuvww	253	23	,	,	,
cord-291727-4wfhuvww	253	24	2003	2003	CD
cord-291727-4wfhuvww	253	25	)	)	-RRB-
cord-291727-4wfhuvww	253	26	.	.	.
cord-291727-4wfhuvww	254	1	For	for	IN
cord-291727-4wfhuvww	254	2	instance	instance	NN
cord-291727-4wfhuvww	254	3	,	,	,
cord-291727-4wfhuvww	254	4	a	a	DT
cord-291727-4wfhuvww	254	5	random	random	JJ
cord-291727-4wfhuvww	254	6	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	254	7	sequence	sequence	NN
cord-291727-4wfhuvww	254	8	can	can	MD
cord-291727-4wfhuvww	254	9	be	be	VB
cord-291727-4wfhuvww	254	10	inserted	insert	VBN
cord-291727-4wfhuvww	254	11	between	between	IN
cord-291727-4wfhuvww	254	12	the	the	DT
cord-291727-4wfhuvww	254	13	in	in	IN
cord-291727-4wfhuvww	254	14	-	-	HYPH
cord-291727-4wfhuvww	254	15	frame	frame	NN
cord-291727-4wfhuvww	254	16	and	and	CC
cord-291727-4wfhuvww	254	17	the	the	DT
cord-291727-4wfhuvww	254	18	out	out	JJ
cord-291727-4wfhuvww	254	19	-	-	HYPH
cord-291727-4wfhuvww	254	20	of	of	IN
cord-291727-4wfhuvww	254	21	-	-	HYPH
cord-291727-4wfhuvww	254	22	frame	frame	NN
cord-291727-4wfhuvww	254	23	luciferase	luciferase	NN
cord-291727-4wfhuvww	254	24	to	to	TO
cord-291727-4wfhuvww	254	25	determine	determine	VB
cord-291727-4wfhuvww	254	26	which	which	WDT
cord-291727-4wfhuvww	254	27	sequence	sequence	NN
cord-291727-4wfhuvww	254	28	will	will	MD
cord-291727-4wfhuvww	254	29	result	result	VB
cord-291727-4wfhuvww	254	30	in	in	IN
cord-291727-4wfhuvww	254	31	high	high	JJ
cord-291727-4wfhuvww	254	32	levels	level	NNS
cord-291727-4wfhuvww	254	33	of	of	IN
cord-291727-4wfhuvww	254	34	out	out	IN
cord-291727-4wfhuvww	254	35	-	-	HYPH
cord-291727-4wfhuvww	254	36	of	of	IN
cord-291727-4wfhuvww	254	37	-	-	HYPH
cord-291727-4wfhuvww	254	38	frame	frame	NN
cord-291727-4wfhuvww	254	39	expression	expression	NN
cord-291727-4wfhuvww	254	40	.	.	.
cord-291727-4wfhuvww	255	1	The	the	DT
cord-291727-4wfhuvww	255	2	main	main	JJ
cord-291727-4wfhuvww	255	3	advantages	advantage	NNS
cord-291727-4wfhuvww	255	4	of	of	IN
cord-291727-4wfhuvww	255	5	such	such	PDT
cord-291727-4wfhuvww	255	6	a	a	DT
cord-291727-4wfhuvww	255	7	system	system	NN
cord-291727-4wfhuvww	255	8	are	be	VBP
cord-291727-4wfhuvww	255	9	the	the	DT
cord-291727-4wfhuvww	255	10	broad	broad	JJ
cord-291727-4wfhuvww	255	11	linear	linear	JJ
cord-291727-4wfhuvww	255	12	range	range	NN
cord-291727-4wfhuvww	255	13	of	of	IN
cord-291727-4wfhuvww	255	14	the	the	DT
cord-291727-4wfhuvww	255	15	assay	assay	NN
cord-291727-4wfhuvww	255	16	,	,	,
cord-291727-4wfhuvww	255	17	the	the	DT
cord-291727-4wfhuvww	255	18	internal	internal	JJ
cord-291727-4wfhuvww	255	19	mRNA	mRNA	NNP
cord-291727-4wfhuvww	255	20	expression	expression	NN
cord-291727-4wfhuvww	255	21	control	control	NN
cord-291727-4wfhuvww	255	22	(	(	-LRB-
cord-291727-4wfhuvww	255	23	luciferase	luciferase	NNP
cord-291727-4wfhuvww	255	24	1	1	CD
cord-291727-4wfhuvww	255	25	)	)	-RRB-
cord-291727-4wfhuvww	255	26	,	,	,
cord-291727-4wfhuvww	255	27	the	the	DT
cord-291727-4wfhuvww	255	28	possibility	possibility	NN
cord-291727-4wfhuvww	255	29	to	to	TO
cord-291727-4wfhuvww	255	30	normalize	normalize	VB
cord-291727-4wfhuvww	255	31	relative	relative	JJ
cord-291727-4wfhuvww	255	32	frameshift	frameshift	NN
cord-291727-4wfhuvww	255	33	expression	expression	NN
cord-291727-4wfhuvww	255	34	,	,	,
cord-291727-4wfhuvww	255	35	and	and	CC
cord-291727-4wfhuvww	255	36	the	the	DT
cord-291727-4wfhuvww	255	37	ease	ease	NN
cord-291727-4wfhuvww	255	38	of	of	IN
cord-291727-4wfhuvww	255	39	use	use	NN
cord-291727-4wfhuvww	255	40	.	.	.
cord-291727-4wfhuvww	256	1	One	one	CD
cord-291727-4wfhuvww	256	2	problem	problem	NN
cord-291727-4wfhuvww	256	3	with	with	IN
cord-291727-4wfhuvww	256	4	the	the	DT
cord-291727-4wfhuvww	256	5	approach	approach	NN
cord-291727-4wfhuvww	256	6	is	be	VBZ
cord-291727-4wfhuvww	256	7	that	that	IN
cord-291727-4wfhuvww	256	8	the	the	DT
cord-291727-4wfhuvww	256	9	secondary	secondary	JJ
cord-291727-4wfhuvww	256	10	structure	structure	NN
cord-291727-4wfhuvww	256	11	is	be	VBZ
cord-291727-4wfhuvww	256	12	affected	affect	VBN
cord-291727-4wfhuvww	256	13	by	by	IN
cord-291727-4wfhuvww	256	14	the	the	DT
cord-291727-4wfhuvww	256	15	length	length	NN
cord-291727-4wfhuvww	256	16	of	of	IN
cord-291727-4wfhuvww	256	17	the	the	DT
cord-291727-4wfhuvww	256	18	sequence	sequence	NN
cord-291727-4wfhuvww	256	19	inserted	insert	VBN
cord-291727-4wfhuvww	256	20	in	in	IN
cord-291727-4wfhuvww	256	21	the	the	DT
cord-291727-4wfhuvww	256	22	dual	dual	JJ
cord-291727-4wfhuvww	256	23	luciferase	luciferase	NN
cord-291727-4wfhuvww	256	24	reporter	reporter	NN
cord-291727-4wfhuvww	256	25	.	.	.
cord-291727-4wfhuvww	257	1	Thus	thus	RB
cord-291727-4wfhuvww	257	2	,	,	,
cord-291727-4wfhuvww	257	3	the	the	DT
cord-291727-4wfhuvww	257	4	context	context	NN
cord-291727-4wfhuvww	257	5	of	of	IN
cord-291727-4wfhuvww	257	6	the	the	DT
cord-291727-4wfhuvww	257	7	frameshift	frameshift	NN
cord-291727-4wfhuvww	257	8	motifs	motif	NNS
cord-291727-4wfhuvww	257	9	needs	need	VBZ
cord-291727-4wfhuvww	257	10	to	to	TO
cord-291727-4wfhuvww	257	11	be	be	VB
cord-291727-4wfhuvww	257	12	taken	take	VBN
cord-291727-4wfhuvww	257	13	into	into	IN
cord-291727-4wfhuvww	257	14	account	account	NN
cord-291727-4wfhuvww	257	15	.	.	.
cord-291727-4wfhuvww	258	1	Further	further	RB
cord-291727-4wfhuvww	258	2	,	,	,
cord-291727-4wfhuvww	258	3	the	the	DT
cord-291727-4wfhuvww	258	4	high	high	JJ
cord-291727-4wfhuvww	258	5	number	number	NN
cord-291727-4wfhuvww	258	6	of	of	IN
cord-291727-4wfhuvww	258	7	potential	potential	JJ
cord-291727-4wfhuvww	258	8	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	258	9	combinations	combination	NNS
cord-291727-4wfhuvww	258	10	may	may	MD
cord-291727-4wfhuvww	258	11	outweigh	outweigh	VB
cord-291727-4wfhuvww	258	12	the	the	DT
cord-291727-4wfhuvww	258	13	capacity	capacity	NN
cord-291727-4wfhuvww	258	14	of	of	IN
cord-291727-4wfhuvww	258	15	even	even	RB
cord-291727-4wfhuvww	258	16	highly	highly	RB
cord-291727-4wfhuvww	258	17	automated	automate	VBN
cord-291727-4wfhuvww	258	18	processes	process	NNS
cord-291727-4wfhuvww	258	19	.	.	.
cord-291727-4wfhuvww	259	1	Even	even	RB
cord-291727-4wfhuvww	259	2	though	though	IN
cord-291727-4wfhuvww	259	3	this	this	DT
cord-291727-4wfhuvww	259	4	will	will	MD
cord-291727-4wfhuvww	259	5	identify	identify	VB
cord-291727-4wfhuvww	259	6	putative	putative	JJ
cord-291727-4wfhuvww	259	7	sequences	sequence	NNS
cord-291727-4wfhuvww	259	8	with	with	IN
cord-291727-4wfhuvww	259	9	high	high	JJ
cord-291727-4wfhuvww	259	10	potential	potential	NN
cord-291727-4wfhuvww	259	11	for	for	IN
cord-291727-4wfhuvww	259	12	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	259	13	,	,	,
cord-291727-4wfhuvww	259	14	it	-PRON-	PRP
cord-291727-4wfhuvww	259	15	is	be	VBZ
cord-291727-4wfhuvww	259	16	still	still	RB
cord-291727-4wfhuvww	259	17	not	not	RB
cord-291727-4wfhuvww	259	18	clear	clear	JJ
cord-291727-4wfhuvww	259	19	whether	whether	IN
cord-291727-4wfhuvww	259	20	the	the	DT
cord-291727-4wfhuvww	259	21	out	out	JJ
cord-291727-4wfhuvww	259	22	-	-	HYPH
cord-291727-4wfhuvww	259	23	of	of	IN
cord-291727-4wfhuvww	259	24	-	-	HYPH
cord-291727-4wfhuvww	259	25	frame	frame	NN
cord-291727-4wfhuvww	259	26	peptides	peptide	NNS
cord-291727-4wfhuvww	259	27	or	or	CC
cord-291727-4wfhuvww	259	28	proteins	protein	NNS
cord-291727-4wfhuvww	259	29	are	be	VBP
cord-291727-4wfhuvww	259	30	stable	stable	JJ
cord-291727-4wfhuvww	259	31	and	and	CC
cord-291727-4wfhuvww	259	32	functional	functional	JJ
cord-291727-4wfhuvww	259	33	.	.	.
cord-291727-4wfhuvww	260	1	Their	-PRON-	PRP$
cord-291727-4wfhuvww	260	2	presence	presence	NN
cord-291727-4wfhuvww	260	3	in	in	IN
cord-291727-4wfhuvww	260	4	open	open	JJ
cord-291727-4wfhuvww	260	5	reading	reading	NN
cord-291727-4wfhuvww	260	6	frames	frame	NNS
cord-291727-4wfhuvww	260	7	may	may	MD
cord-291727-4wfhuvww	260	8	hint	hint	VB
cord-291727-4wfhuvww	260	9	that	that	IN
cord-291727-4wfhuvww	260	10	a	a	DT
cord-291727-4wfhuvww	260	11	frameshift	frameshift	NN
cord-291727-4wfhuvww	260	12	is	be	VBZ
cord-291727-4wfhuvww	260	13	buried	bury	VBN
cord-291727-4wfhuvww	260	14	within	within	IN
cord-291727-4wfhuvww	260	15	the	the	DT
cord-291727-4wfhuvww	260	16	gene	gene	NN
cord-291727-4wfhuvww	260	17	.	.	.
cord-291727-4wfhuvww	261	1	Subsequent	subsequent	JJ
cord-291727-4wfhuvww	261	2	low	low	JJ
cord-291727-4wfhuvww	261	3	-	-	HYPH
cord-291727-4wfhuvww	261	4	throughput	throughput	NN
cord-291727-4wfhuvww	261	5	experimental	experimental	JJ
cord-291727-4wfhuvww	261	6	methods	method	NNS
cord-291727-4wfhuvww	261	7	(	(	-LRB-
cord-291727-4wfhuvww	261	8	see	see	VB
cord-291727-4wfhuvww	261	9	above	above	RB
cord-291727-4wfhuvww	261	10	)	)	-RRB-
cord-291727-4wfhuvww	261	11	need	need	VB
cord-291727-4wfhuvww	261	12	to	to	TO
cord-291727-4wfhuvww	261	13	be	be	VB
cord-291727-4wfhuvww	261	14	designed	design	VBN
cord-291727-4wfhuvww	261	15	to	to	TO
cord-291727-4wfhuvww	261	16	confirm	confirm	VB
cord-291727-4wfhuvww	261	17	expression	expression	NN
cord-291727-4wfhuvww	261	18	of	of	IN
cord-291727-4wfhuvww	261	19	the	the	DT
cord-291727-4wfhuvww	261	20	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	261	21	protein	protein	NN
cord-291727-4wfhuvww	261	22	.	.	.
cord-291727-4wfhuvww	262	1	Proteomic	proteomic	JJ
cord-291727-4wfhuvww	262	2	approaches	approach	NNS
cord-291727-4wfhuvww	262	3	have	have	VBP
cord-291727-4wfhuvww	262	4	enabled	enable	VBN
cord-291727-4wfhuvww	262	5	the	the	DT
cord-291727-4wfhuvww	262	6	identification	identification	NN
cord-291727-4wfhuvww	262	7	of	of	IN
cord-291727-4wfhuvww	262	8	expressed	express	VBN
cord-291727-4wfhuvww	262	9	peptides	peptide	NNS
cord-291727-4wfhuvww	262	10	under	under	IN
cord-291727-4wfhuvww	262	11	physiological	physiological	JJ
cord-291727-4wfhuvww	262	12	conditions	condition	NNS
cord-291727-4wfhuvww	262	13	.	.	.
cord-291727-4wfhuvww	263	1	In	in	IN
cord-291727-4wfhuvww	263	2	mass	mass	NN
cord-291727-4wfhuvww	263	3	spectrometry	spectrometry	NN
cord-291727-4wfhuvww	263	4	(	(	-LRB-
cord-291727-4wfhuvww	263	5	MS	MS	NNP
cord-291727-4wfhuvww	263	6	)	)	-RRB-
cord-291727-4wfhuvww	263	7	,	,	,
cord-291727-4wfhuvww	263	8	peptides	peptide	NNS
cord-291727-4wfhuvww	263	9	of	of	IN
cord-291727-4wfhuvww	263	10	endogenous	endogenous	JJ
cord-291727-4wfhuvww	263	11	proteins	protein	NNS
cord-291727-4wfhuvww	263	12	are	be	VBP
cord-291727-4wfhuvww	263	13	first	first	RB
cord-291727-4wfhuvww	263	14	detected	detect	VBN
cord-291727-4wfhuvww	263	15	as	as	IN
cord-291727-4wfhuvww	263	16	a	a	DT
cord-291727-4wfhuvww	263	17	mass	mass	NN
cord-291727-4wfhuvww	263	18	per	per	IN
cord-291727-4wfhuvww	263	19	ion	ion	NN
cord-291727-4wfhuvww	263	20	.	.	.
cord-291727-4wfhuvww	264	1	In	in	IN
cord-291727-4wfhuvww	264	2	the	the	DT
cord-291727-4wfhuvww	264	3	most	most	RBS
cord-291727-4wfhuvww	264	4	common	common	JJ
cord-291727-4wfhuvww	264	5	approach	approach	NN
cord-291727-4wfhuvww	264	6	,	,	,
cord-291727-4wfhuvww	264	7	recorded	record	VBN
cord-291727-4wfhuvww	264	8	masses	masse	NNS
cord-291727-4wfhuvww	264	9	are	be	VBP
cord-291727-4wfhuvww	264	10	matched	match	VBN
cord-291727-4wfhuvww	264	11	to	to	IN
cord-291727-4wfhuvww	264	12	all	all	DT
cord-291727-4wfhuvww	264	13	potential	potential	JJ
cord-291727-4wfhuvww	264	14	masses	masse	NNS
cord-291727-4wfhuvww	264	15	in	in	IN
cord-291727-4wfhuvww	264	16	the	the	DT
cord-291727-4wfhuvww	264	17	respective	respective	JJ
cord-291727-4wfhuvww	264	18	database	database	NN
cord-291727-4wfhuvww	264	19	by	by	IN
cord-291727-4wfhuvww	264	20	search	search	NN
cord-291727-4wfhuvww	264	21	algorithms	algorithm	NNS
cord-291727-4wfhuvww	264	22	like	like	IN
cord-291727-4wfhuvww	264	23	SEQUEST	SEQUEST	NNP
cord-291727-4wfhuvww	264	24	,	,	,
cord-291727-4wfhuvww	264	25	MASCOT	MASCOT	NNP
cord-291727-4wfhuvww	264	26	,	,	,
cord-291727-4wfhuvww	264	27	Andromeda	Andromeda	NNP
cord-291727-4wfhuvww	264	28	,	,	,
cord-291727-4wfhuvww	264	29	or	or	CC
cord-291727-4wfhuvww	264	30	PEAKS	peak	NNS
cord-291727-4wfhuvww	264	31	.	.	.
cord-291727-4wfhuvww	265	1	In	in	IN
cord-291727-4wfhuvww	265	2	a	a	DT
cord-291727-4wfhuvww	265	3	next	next	JJ
cord-291727-4wfhuvww	265	4	step	step	NN
cord-291727-4wfhuvww	265	5	,	,	,
cord-291727-4wfhuvww	265	6	sequence	sequence	NN
cord-291727-4wfhuvww	265	7	information	information	NN
cord-291727-4wfhuvww	265	8	generated	generate	VBN
cord-291727-4wfhuvww	265	9	in	in	IN
cord-291727-4wfhuvww	265	10	tandem	tandem	JJ
cord-291727-4wfhuvww	265	11	MS	MS	NNP
cord-291727-4wfhuvww	265	12	(	(	-LRB-
cord-291727-4wfhuvww	265	13	MS	MS	NNP
cord-291727-4wfhuvww	265	14	/	/	SYM
cord-291727-4wfhuvww	265	15	MS	MS	NNP
cord-291727-4wfhuvww	265	16	)	)	-RRB-
cord-291727-4wfhuvww	265	17	experiments	experiment	NNS
cord-291727-4wfhuvww	265	18	is	be	VBZ
cord-291727-4wfhuvww	265	19	employed	employ	VBN
cord-291727-4wfhuvww	265	20	to	to	TO
cord-291727-4wfhuvww	265	21	identify	identify	VB
cord-291727-4wfhuvww	265	22	potential	potential	JJ
cord-291727-4wfhuvww	265	23	hits	hit	NNS
cord-291727-4wfhuvww	265	24	within	within	IN
cord-291727-4wfhuvww	265	25	the	the	DT
cord-291727-4wfhuvww	265	26	shortlisted	shortlist	VBN
cord-291727-4wfhuvww	265	27	peptide	peptide	NN
cord-291727-4wfhuvww	265	28	variants	variant	NNS
cord-291727-4wfhuvww	265	29	.	.	.
cord-291727-4wfhuvww	266	1	Commonly	commonly	RB
cord-291727-4wfhuvww	266	2	searched	search	VBN
cord-291727-4wfhuvww	266	3	databases	database	NNS
cord-291727-4wfhuvww	266	4	by	by	IN
cord-291727-4wfhuvww	266	5	MASCOT	mascot	NN
cord-291727-4wfhuvww	266	6	are	be	VBP
cord-291727-4wfhuvww	266	7	SwissProt	SwissProt	NNP
cord-291727-4wfhuvww	266	8	,	,	,
cord-291727-4wfhuvww	266	9	NCBInr	NCBInr	NNP
cord-291727-4wfhuvww	266	10	,	,	,
cord-291727-4wfhuvww	266	11	and	and	CC
cord-291727-4wfhuvww	266	12	EMBL	EMBL	NNP
cord-291727-4wfhuvww	266	13	EST	EST	NNP
cord-291727-4wfhuvww	266	14	.	.	.
cord-291727-4wfhuvww	267	1	These	these	DT
cord-291727-4wfhuvww	267	2	databases	database	NNS
cord-291727-4wfhuvww	267	3	integrate	integrate	VBP
cord-291727-4wfhuvww	267	4	cDNA	cDNA	NNP
cord-291727-4wfhuvww	267	5	and	and	CC
cord-291727-4wfhuvww	267	6	EST	est	NN
cord-291727-4wfhuvww	267	7	sequences	sequence	NNS
cord-291727-4wfhuvww	267	8	and	and	CC
cord-291727-4wfhuvww	267	9	generally	generally	RB
cord-291727-4wfhuvww	267	10	do	do	VBP
cord-291727-4wfhuvww	267	11	not	not	RB
cord-291727-4wfhuvww	267	12	contain	contain	VB
cord-291727-4wfhuvww	267	13	out	out	RP
cord-291727-4wfhuvww	267	14	-	-	HYPH
cord-291727-4wfhuvww	267	15	of	of	IN
cord-291727-4wfhuvww	267	16	-	-	HYPH
cord-291727-4wfhuvww	267	17	frame	frame	NN
cord-291727-4wfhuvww	267	18	peptides	peptide	NNS
cord-291727-4wfhuvww	267	19	.	.	.
cord-291727-4wfhuvww	268	1	However	however	RB
cord-291727-4wfhuvww	268	2	,	,	,
cord-291727-4wfhuvww	268	3	as	as	IN
cord-291727-4wfhuvww	268	4	MS	MS	NNP
cord-291727-4wfhuvww	268	5	database	database	NN
cord-291727-4wfhuvww	268	6	search	search	NN
cord-291727-4wfhuvww	268	7	algorithms	algorithm	NNS
cord-291727-4wfhuvww	268	8	compute	compute	VBP
cord-291727-4wfhuvww	268	9	the	the	DT
cord-291727-4wfhuvww	268	10	entire	entire	JJ
cord-291727-4wfhuvww	268	11	sequence	sequence	NN
cord-291727-4wfhuvww	268	12	space	space	NN
cord-291727-4wfhuvww	268	13	of	of	IN
cord-291727-4wfhuvww	268	14	potential	potential	JJ
cord-291727-4wfhuvww	268	15	peptide	peptide	NN
cord-291727-4wfhuvww	268	16	matches	match	NNS
cord-291727-4wfhuvww	268	17	to	to	TO
cord-291727-4wfhuvww	268	18	identify	identify	VB
cord-291727-4wfhuvww	268	19	peptides	peptide	NNS
cord-291727-4wfhuvww	268	20	within	within	IN
cord-291727-4wfhuvww	268	21	analyzed	analyze	VBN
cord-291727-4wfhuvww	268	22	samples	sample	NNS
cord-291727-4wfhuvww	268	23	,	,	,
cord-291727-4wfhuvww	268	24	it	-PRON-	PRP
cord-291727-4wfhuvww	268	25	is	be	VBZ
cord-291727-4wfhuvww	268	26	in	in	IN
cord-291727-4wfhuvww	268	27	principle	principle	NN
cord-291727-4wfhuvww	268	28	possible	possible	JJ
cord-291727-4wfhuvww	268	29	to	to	TO
cord-291727-4wfhuvww	268	30	identify	identify	VB
cord-291727-4wfhuvww	268	31	out	out	RP
cord-291727-4wfhuvww	268	32	-	-	HYPH
cord-291727-4wfhuvww	268	33	of	of	IN
cord-291727-4wfhuvww	268	34	-	-	HYPH
cord-291727-4wfhuvww	268	35	frame	frame	NN
cord-291727-4wfhuvww	268	36	peptides	peptide	NNS
cord-291727-4wfhuvww	268	37	.	.	.
cord-291727-4wfhuvww	269	1	An	an	DT
cord-291727-4wfhuvww	269	2	interesting	interesting	JJ
cord-291727-4wfhuvww	269	3	approach	approach	NN
cord-291727-4wfhuvww	269	4	for	for	IN
cord-291727-4wfhuvww	269	5	the	the	DT
cord-291727-4wfhuvww	269	6	identification	identification	NN
cord-291727-4wfhuvww	269	7	of	of	IN
cord-291727-4wfhuvww	269	8	frame	frame	JJ
cord-291727-4wfhuvww	269	9	-	-	HYPH
cord-291727-4wfhuvww	269	10	shift	shift	NN
cord-291727-4wfhuvww	269	11	peptides	peptide	NNS
cord-291727-4wfhuvww	269	12	is	be	VBZ
cord-291727-4wfhuvww	269	13	de	de	FW
cord-291727-4wfhuvww	269	14	novo	novo	NNP
cord-291727-4wfhuvww	269	15	sequence	sequence	NN
cord-291727-4wfhuvww	269	16	analysis	analysis	NN
cord-291727-4wfhuvww	269	17	by	by	IN
cord-291727-4wfhuvww	269	18	MS	MS	NNP
cord-291727-4wfhuvww	269	19	.	.	.
cord-291727-4wfhuvww	270	1	This	this	DT
cord-291727-4wfhuvww	270	2	is	be	VBZ
cord-291727-4wfhuvww	270	3	based	base	VBN
cord-291727-4wfhuvww	270	4	solely	solely	RB
cord-291727-4wfhuvww	270	5	on	on	IN
cord-291727-4wfhuvww	270	6	the	the	DT
cord-291727-4wfhuvww	270	7	analysis	analysis	NN
cord-291727-4wfhuvww	270	8	of	of	IN
cord-291727-4wfhuvww	270	9	MS	MS	NNP
cord-291727-4wfhuvww	270	10	and	and	CC
cord-291727-4wfhuvww	270	11	MS	MS	NNP
cord-291727-4wfhuvww	270	12	/	/	SYM
cord-291727-4wfhuvww	270	13	MS	MS	NNP
cord-291727-4wfhuvww	270	14	spectra	spectra	NNP
cord-291727-4wfhuvww	270	15	,	,	,
cord-291727-4wfhuvww	270	16	without	without	IN
cord-291727-4wfhuvww	270	17	amino	amino	NN
cord-291727-4wfhuvww	270	18	acid	acid	NN
cord-291727-4wfhuvww	270	19	sequence	sequence	NN
cord-291727-4wfhuvww	270	20	information	information	NN
cord-291727-4wfhuvww	270	21	from	from	IN
cord-291727-4wfhuvww	270	22	databases	database	NNS
cord-291727-4wfhuvww	270	23	.	.	.
cord-291727-4wfhuvww	271	1	However	however	RB
cord-291727-4wfhuvww	271	2	,	,	,
cord-291727-4wfhuvww	271	3	identification	identification	NN
cord-291727-4wfhuvww	271	4	rates	rate	NNS
cord-291727-4wfhuvww	271	5	are	be	VBP
cord-291727-4wfhuvww	271	6	typically	typically	RB
cord-291727-4wfhuvww	271	7	lower	low	JJR
cord-291727-4wfhuvww	271	8	than	than	IN
cord-291727-4wfhuvww	271	9	in	in	IN
cord-291727-4wfhuvww	271	10	classical	classical	JJ
cord-291727-4wfhuvww	271	11	database	database	NN
cord-291727-4wfhuvww	271	12	-	-	HYPH
cord-291727-4wfhuvww	271	13	based	base	VBN
cord-291727-4wfhuvww	271	14	proteomics	proteomic	NNS
cord-291727-4wfhuvww	271	15	experiments	experiment	NNS
cord-291727-4wfhuvww	271	16	.	.	.
cord-291727-4wfhuvww	272	1	A	a	DT
cord-291727-4wfhuvww	272	2	major	major	JJ
cord-291727-4wfhuvww	272	3	difficulty	difficulty	NN
cord-291727-4wfhuvww	272	4	is	be	VBZ
cord-291727-4wfhuvww	272	5	to	to	TO
cord-291727-4wfhuvww	272	6	assign	assign	VB
cord-291727-4wfhuvww	272	7	frame	frame	NN
cord-291727-4wfhuvww	272	8	-	-	HYPH
cord-291727-4wfhuvww	272	9	shifted	shift	VBN
cord-291727-4wfhuvww	272	10	peptides	peptide	NNS
cord-291727-4wfhuvww	272	11	to	to	IN
cord-291727-4wfhuvww	272	12	a	a	DT
cord-291727-4wfhuvww	272	13	particular	particular	JJ
cord-291727-4wfhuvww	272	14	gene	gene	NN
cord-291727-4wfhuvww	272	15	.	.	.
cord-291727-4wfhuvww	273	1	Decoding	decode	VBG
cord-291727-4wfhuvww	273	2	of	of	IN
cord-291727-4wfhuvww	273	3	the	the	DT
cord-291727-4wfhuvww	273	4	underlying	underlying	JJ
cord-291727-4wfhuvww	273	5	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	273	6	sequence	sequence	NN
cord-291727-4wfhuvww	273	7	is	be	VBZ
cord-291727-4wfhuvww	273	8	sometimes	sometimes	RB
cord-291727-4wfhuvww	273	9	problematic	problematic	JJ
cord-291727-4wfhuvww	273	10	,	,	,
cord-291727-4wfhuvww	273	11	as	as	IN
cord-291727-4wfhuvww	273	12	,	,	,
cord-291727-4wfhuvww	273	13	for	for	IN
cord-291727-4wfhuvww	273	14	instance	instance	NN
cord-291727-4wfhuvww	273	15	,	,	,
cord-291727-4wfhuvww	273	16	isoleucine	isoleucine	NNP
cord-291727-4wfhuvww	273	17	and	and	CC
cord-291727-4wfhuvww	273	18	leucine	leucine	NN
cord-291727-4wfhuvww	273	19	have	have	VBP
cord-291727-4wfhuvww	273	20	the	the	DT
cord-291727-4wfhuvww	273	21	same	same	JJ
cord-291727-4wfhuvww	273	22	exact	exact	JJ
cord-291727-4wfhuvww	273	23	mass	mass	NN
cord-291727-4wfhuvww	273	24	.	.	.
cord-291727-4wfhuvww	274	1	In	in	IN
cord-291727-4wfhuvww	274	2	some	some	DT
cord-291727-4wfhuvww	274	3	cases	case	NNS
cord-291727-4wfhuvww	274	4	,	,	,
cord-291727-4wfhuvww	274	5	the	the	DT
cord-291727-4wfhuvww	274	6	identified	identify	VBN
cord-291727-4wfhuvww	274	7	peptides	peptide	NNS
cord-291727-4wfhuvww	274	8	do	do	VBP
cord-291727-4wfhuvww	274	9	not	not	RB
cord-291727-4wfhuvww	274	10	match	match	VB
cord-291727-4wfhuvww	274	11	the	the	DT
cord-291727-4wfhuvww	274	12	database	database	NN
cord-291727-4wfhuvww	274	13	for	for	IN
cord-291727-4wfhuvww	274	14	various	various	JJ
cord-291727-4wfhuvww	274	15	reasons	reason	NNS
cord-291727-4wfhuvww	274	16	,	,	,
cord-291727-4wfhuvww	274	17	including	include	VBG
cord-291727-4wfhuvww	274	18	errors	error	NNS
cord-291727-4wfhuvww	274	19	in	in	IN
cord-291727-4wfhuvww	274	20	gene	gene	NN
cord-291727-4wfhuvww	274	21	/	/	SYM
cord-291727-4wfhuvww	274	22	protein	protein	NN
cord-291727-4wfhuvww	274	23	annotation	annotation	NN
cord-291727-4wfhuvww	274	24	and	and	CC
cord-291727-4wfhuvww	274	25	post	post	JJ
cord-291727-4wfhuvww	274	26	-	-	JJ
cord-291727-4wfhuvww	274	27	translational	translational	JJ
cord-291727-4wfhuvww	274	28	modifications	modification	NNS
cord-291727-4wfhuvww	274	29	in	in	IN
cord-291727-4wfhuvww	274	30	the	the	DT
cord-291727-4wfhuvww	274	31	peptides	peptide	NNS
cord-291727-4wfhuvww	274	32	that	that	WDT
cord-291727-4wfhuvww	274	33	are	be	VBP
cord-291727-4wfhuvww	274	34	not	not	RB
cord-291727-4wfhuvww	274	35	accounted	account	VBN
cord-291727-4wfhuvww	274	36	for	for	IN
cord-291727-4wfhuvww	274	37	.	.	.
cord-291727-4wfhuvww	275	1	Usually	usually	RB
cord-291727-4wfhuvww	275	2	,	,	,
cord-291727-4wfhuvww	275	3	unmatched	unmatched	JJ
cord-291727-4wfhuvww	275	4	peptides	peptide	NNS
cord-291727-4wfhuvww	275	5	are	be	VBP
cord-291727-4wfhuvww	275	6	not	not	RB
cord-291727-4wfhuvww	275	7	reported	report	VBN
cord-291727-4wfhuvww	275	8	in	in	IN
cord-291727-4wfhuvww	275	9	publications	publication	NNS
cord-291727-4wfhuvww	275	10	and	and	CC
cord-291727-4wfhuvww	275	11	are	be	VBP
cord-291727-4wfhuvww	275	12	disregarded	disregard	VBN
cord-291727-4wfhuvww	275	13	from	from	IN
cord-291727-4wfhuvww	275	14	further	further	JJ
cord-291727-4wfhuvww	275	15	analysis	analysis	NN
cord-291727-4wfhuvww	275	16	.	.	.
cord-291727-4wfhuvww	276	1	It	-PRON-	PRP
cord-291727-4wfhuvww	276	2	is	be	VBZ
cord-291727-4wfhuvww	276	3	possible	possible	JJ
cord-291727-4wfhuvww	276	4	that	that	IN
cord-291727-4wfhuvww	276	5	some	some	DT
cord-291727-4wfhuvww	276	6	of	of	IN
cord-291727-4wfhuvww	276	7	these	these	DT
cord-291727-4wfhuvww	276	8	unmatched	unmatched	JJ
cord-291727-4wfhuvww	276	9	peptides	peptide	NNS
cord-291727-4wfhuvww	276	10	correspond	correspond	VBP
cord-291727-4wfhuvww	276	11	to	to	IN
cord-291727-4wfhuvww	276	12	an	an	DT
cord-291727-4wfhuvww	276	13	alternative	alternative	JJ
cord-291727-4wfhuvww	276	14	reading	reading	NN
cord-291727-4wfhuvww	276	15	frame	frame	NN
cord-291727-4wfhuvww	276	16	.	.	.
cord-291727-4wfhuvww	277	1	In	in	IN
cord-291727-4wfhuvww	277	2	order	order	NN
cord-291727-4wfhuvww	277	3	to	to	TO
cord-291727-4wfhuvww	277	4	match	match	VB
cord-291727-4wfhuvww	277	5	these	these	DT
cord-291727-4wfhuvww	277	6	peptides	peptide	NNS
cord-291727-4wfhuvww	277	7	,	,	,
cord-291727-4wfhuvww	277	8	one	one	PRP
cord-291727-4wfhuvww	277	9	would	would	MD
cord-291727-4wfhuvww	277	10	need	need	VB
cord-291727-4wfhuvww	277	11	to	to	TO
cord-291727-4wfhuvww	277	12	generate	generate	VB
cord-291727-4wfhuvww	277	13	a	a	DT
cord-291727-4wfhuvww	277	14	database	database	NN
cord-291727-4wfhuvww	277	15	derived	derive	VBN
cord-291727-4wfhuvww	277	16	from	from	IN
cord-291727-4wfhuvww	277	17	the	the	DT
cord-291727-4wfhuvww	277	18	+1/−1	+1/−1	JJ
cord-291727-4wfhuvww	277	19	frames	frame	NNS
cord-291727-4wfhuvww	277	20	of	of	IN
cord-291727-4wfhuvww	277	21	the	the	DT
cord-291727-4wfhuvww	277	22	ORFeome	ORFeome	NNP
cord-291727-4wfhuvww	277	23	,	,	,
cord-291727-4wfhuvww	277	24	similar	similar	JJ
cord-291727-4wfhuvww	277	25	to	to	IN
cord-291727-4wfhuvww	277	26	what	what	WP
cord-291727-4wfhuvww	277	27	Okamura	Okamura	NNP
cord-291727-4wfhuvww	277	28	et	et	NNP
cord-291727-4wfhuvww	277	29	al	al	NNP
cord-291727-4wfhuvww	277	30	.	.	NNP
cord-291727-4wfhuvww	277	31	have	have	VBP
cord-291727-4wfhuvww	277	32	done	do	VBN
cord-291727-4wfhuvww	277	33	(	(	-LRB-
cord-291727-4wfhuvww	277	34	Okamura	Okamura	NNP
cord-291727-4wfhuvww	277	35	et	et	NNP
cord-291727-4wfhuvww	277	36	al	al	NNP
cord-291727-4wfhuvww	277	37	.	.	NNP
cord-291727-4wfhuvww	277	38	,	,	,
cord-291727-4wfhuvww	277	39	2006	2006	CD
cord-291727-4wfhuvww	277	40	)	)	-RRB-
cord-291727-4wfhuvww	277	41	,	,	,
cord-291727-4wfhuvww	277	42	and	and	CC
cord-291727-4wfhuvww	277	43	make	make	VB
cord-291727-4wfhuvww	277	44	these	these	DT
cord-291727-4wfhuvww	277	45	accessible	accessible	JJ
cord-291727-4wfhuvww	277	46	to	to	IN
cord-291727-4wfhuvww	277	47	the	the	DT
cord-291727-4wfhuvww	277	48	proteomic	proteomic	JJ
cord-291727-4wfhuvww	277	49	community	community	NN
cord-291727-4wfhuvww	277	50	.	.	.
cord-291727-4wfhuvww	278	1	One	one	CD
cord-291727-4wfhuvww	278	2	problem	problem	NN
cord-291727-4wfhuvww	278	3	is	be	VBZ
cord-291727-4wfhuvww	278	4	the	the	DT
cord-291727-4wfhuvww	278	5	"	"	``
cord-291727-4wfhuvww	278	6	breakpoint	breakpoint	NN
cord-291727-4wfhuvww	278	7	"	"	''
cord-291727-4wfhuvww	278	8	of	of	IN
cord-291727-4wfhuvww	278	9	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	278	10	,	,	,
cord-291727-4wfhuvww	278	11	which	which	WDT
cord-291727-4wfhuvww	278	12	would	would	MD
cord-291727-4wfhuvww	278	13	generate	generate	VB
cord-291727-4wfhuvww	278	14	a	a	DT
cord-291727-4wfhuvww	278	15	peptide	peptide	NN
cord-291727-4wfhuvww	278	16	that	that	WDT
cord-291727-4wfhuvww	278	17	is	be	VBZ
cord-291727-4wfhuvww	278	18	partially	partially	RB
cord-291727-4wfhuvww	278	19	composed	compose	VBN
cord-291727-4wfhuvww	278	20	of	of	IN
cord-291727-4wfhuvww	278	21	the	the	DT
cord-291727-4wfhuvww	278	22	original	original	JJ
cord-291727-4wfhuvww	278	23	frame	frame	NN
cord-291727-4wfhuvww	278	24	and	and	CC
cord-291727-4wfhuvww	278	25	partially	partially	RB
cord-291727-4wfhuvww	278	26	of	of	IN
cord-291727-4wfhuvww	278	27	the	the	DT
cord-291727-4wfhuvww	278	28	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	278	29	peptide	peptide	NN
cord-291727-4wfhuvww	278	30	(	(	-LRB-
cord-291727-4wfhuvww	278	31	see	see	VB
cord-291727-4wfhuvww	278	32	Figure	Figure	NNP
cord-291727-4wfhuvww	278	33	4	4	CD
cord-291727-4wfhuvww	278	34	)	)	-RRB-
cord-291727-4wfhuvww	278	35	.	.	.
cord-291727-4wfhuvww	279	1	Another	another	DT
cord-291727-4wfhuvww	279	2	problem	problem	NN
cord-291727-4wfhuvww	279	3	in	in	IN
cord-291727-4wfhuvww	279	4	this	this	DT
cord-291727-4wfhuvww	279	5	approach	approach	NN
cord-291727-4wfhuvww	279	6	may	may	MD
cord-291727-4wfhuvww	279	7	be	be	VB
cord-291727-4wfhuvww	279	8	the	the	DT
cord-291727-4wfhuvww	279	9	paucity	paucity	NN
cord-291727-4wfhuvww	279	10	of	of	IN
cord-291727-4wfhuvww	279	11	frameshifted	frameshifted	JJ
cord-291727-4wfhuvww	279	12	peptides	peptide	NNS
cord-291727-4wfhuvww	279	13	,	,	,
cord-291727-4wfhuvww	279	14	as	as	IN
cord-291727-4wfhuvww	279	15	they	-PRON-	PRP
cord-291727-4wfhuvww	279	16	are	be	VBP
cord-291727-4wfhuvww	279	17	commonly	commonly	RB
cord-291727-4wfhuvww	279	18	expressed	express	VBN
cord-291727-4wfhuvww	279	19	at	at	IN
cord-291727-4wfhuvww	279	20	lower	low	JJR
cord-291727-4wfhuvww	279	21	levels	level	NNS
cord-291727-4wfhuvww	279	22	(	(	-LRB-
cord-291727-4wfhuvww	279	23	see	see	VB
cord-291727-4wfhuvww	279	24	above	above	RB
cord-291727-4wfhuvww	279	25	)	)	-RRB-
cord-291727-4wfhuvww	279	26	and	and	CC
cord-291727-4wfhuvww	279	27	may	may	MD
cord-291727-4wfhuvww	279	28	not	not	RB
cord-291727-4wfhuvww	279	29	be	be	VB
cord-291727-4wfhuvww	279	30	easily	easily	RB
cord-291727-4wfhuvww	279	31	detectable	detectable	JJ
cord-291727-4wfhuvww	279	32	by	by	IN
cord-291727-4wfhuvww	279	33	MS	MS	NNP
cord-291727-4wfhuvww	279	34	approaches	approach	NNS
cord-291727-4wfhuvww	279	35	.	.	.
cord-291727-4wfhuvww	280	1	However	however	RB
cord-291727-4wfhuvww	280	2	,	,	,
cord-291727-4wfhuvww	280	3	MS	MS	NNP
cord-291727-4wfhuvww	280	4	is	be	VBZ
cord-291727-4wfhuvww	280	5	probably	probably	RB
cord-291727-4wfhuvww	280	6	the	the	DT
cord-291727-4wfhuvww	280	7	most	most	RBS
cord-291727-4wfhuvww	280	8	powerful	powerful	JJ
cord-291727-4wfhuvww	280	9	method	method	NN
cord-291727-4wfhuvww	280	10	to	to	TO
cord-291727-4wfhuvww	280	11	identify	identify	VB
cord-291727-4wfhuvww	280	12	out	out	RP
cord-291727-4wfhuvww	280	13	-	-	HYPH
cord-291727-4wfhuvww	280	14	of	of	IN
cord-291727-4wfhuvww	280	15	-	-	HYPH
cord-291727-4wfhuvww	280	16	frame	frame	NN
cord-291727-4wfhuvww	280	17	peptides	peptide	NNS
cord-291727-4wfhuvww	280	18	to	to	TO
cord-291727-4wfhuvww	280	19	confirm	confirm	VB
cord-291727-4wfhuvww	280	20	endogenous	endogenous	JJ
cord-291727-4wfhuvww	280	21	expression	expression	NN
cord-291727-4wfhuvww	280	22	.	.	.
cord-291727-4wfhuvww	281	1	An	an	DT
cord-291727-4wfhuvww	281	2	alternative	alternative	NN
cord-291727-4wfhuvww	281	3	is	be	VBZ
cord-291727-4wfhuvww	281	4	to	to	TO
cord-291727-4wfhuvww	281	5	study	study	VB
cord-291727-4wfhuvww	281	6	peptides	peptide	NNS
cord-291727-4wfhuvww	281	7	presented	present	VBN
cord-291727-4wfhuvww	281	8	by	by	IN
cord-291727-4wfhuvww	281	9	cell	cell	NN
cord-291727-4wfhuvww	281	10	-	-	HYPH
cord-291727-4wfhuvww	281	11	surface	surface	NN
cord-291727-4wfhuvww	281	12	,	,	,
cord-291727-4wfhuvww	281	13	class	class	NN
cord-291727-4wfhuvww	281	14	I	-PRON-	PRP
cord-291727-4wfhuvww	281	15	MHC	MHC	NNP
cord-291727-4wfhuvww	281	16	proteins	protein	NNS
cord-291727-4wfhuvww	281	17	.	.	.
cord-291727-4wfhuvww	282	1	They	-PRON-	PRP
cord-291727-4wfhuvww	282	2	present	present	VBP
cord-291727-4wfhuvww	282	3	peptides	peptide	NNS
cord-291727-4wfhuvww	282	4	derived	derive	VBN
cord-291727-4wfhuvww	282	5	from	from	IN
cord-291727-4wfhuvww	282	6	intracellular	intracellular	JJ
cord-291727-4wfhuvww	282	7	proteins	protein	NNS
cord-291727-4wfhuvww	282	8	to	to	TO
cord-291727-4wfhuvww	282	9	enable	enable	VB
cord-291727-4wfhuvww	282	10	immune	immune	JJ
cord-291727-4wfhuvww	282	11	tolerance	tolerance	NN
cord-291727-4wfhuvww	282	12	and	and	CC
cord-291727-4wfhuvww	282	13	immune	immune	JJ
cord-291727-4wfhuvww	282	14	surveillance	surveillance	NN
cord-291727-4wfhuvww	282	15	.	.	.
cord-291727-4wfhuvww	283	1	MHC	MHC	NNP
cord-291727-4wfhuvww	283	2	-	-	HYPH
cord-291727-4wfhuvww	283	3	presented	present	VBN
cord-291727-4wfhuvww	283	4	out	out	RB
cord-291727-4wfhuvww	283	5	-	-	HYPH
cord-291727-4wfhuvww	283	6	of	of	IN
cord-291727-4wfhuvww	283	7	-	-	HYPH
cord-291727-4wfhuvww	283	8	frame	frame	NN
cord-291727-4wfhuvww	283	9	peptides	peptide	NNS
cord-291727-4wfhuvww	283	10	were	be	VBD
cord-291727-4wfhuvww	283	11	discovered	discover	VBN
cord-291727-4wfhuvww	283	12	in	in	IN
cord-291727-4wfhuvww	283	13	the	the	DT
cord-291727-4wfhuvww	283	14	early	early	JJ
cord-291727-4wfhuvww	283	15	1990	1990	CD
cord-291727-4wfhuvww	283	16	's	's	POS
cord-291727-4wfhuvww	283	17	(	(	-LRB-
cord-291727-4wfhuvww	283	18	Shastri	Shastri	NNP
cord-291727-4wfhuvww	283	19	et	et	NNP
cord-291727-4wfhuvww	283	20	al	al	NNP
cord-291727-4wfhuvww	283	21	.	.	NNP
cord-291727-4wfhuvww	283	22	,	,	,
cord-291727-4wfhuvww	283	23	1995	1995	CD
cord-291727-4wfhuvww	283	24	)	)	-RRB-
cord-291727-4wfhuvww	283	25	and	and	CC
cord-291727-4wfhuvww	283	26	have	have	VBP
cord-291727-4wfhuvww	283	27	enabled	enable	VBN
cord-291727-4wfhuvww	283	28	the	the	DT
cord-291727-4wfhuvww	283	29	unbiased	unbiased	JJ
cord-291727-4wfhuvww	283	30	identification	identification	NN
cord-291727-4wfhuvww	283	31	of	of	IN
cord-291727-4wfhuvww	283	32	endogenous	endogenous	JJ
cord-291727-4wfhuvww	283	33	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	283	34	in	in	IN
cord-291727-4wfhuvww	283	35	mammalian	mammalian	JJ
cord-291727-4wfhuvww	283	36	cells	cell	NNS
cord-291727-4wfhuvww	283	37	long	long	RB
cord-291727-4wfhuvww	283	38	before	before	IN
cord-291727-4wfhuvww	283	39	the	the	DT
cord-291727-4wfhuvww	283	40	technical	technical	JJ
cord-291727-4wfhuvww	283	41	advances	advance	NNS
cord-291727-4wfhuvww	283	42	of	of	IN
cord-291727-4wfhuvww	283	43	MS	MS	NNP
cord-291727-4wfhuvww	283	44	.	.	.
cord-291727-4wfhuvww	284	1	However	however	RB
cord-291727-4wfhuvww	284	2	,	,	,
cord-291727-4wfhuvww	284	3	it	-PRON-	PRP
cord-291727-4wfhuvww	284	4	is	be	VBZ
cord-291727-4wfhuvww	284	5	technically	technically	RB
cord-291727-4wfhuvww	284	6	challenging	challenging	JJ
cord-291727-4wfhuvww	284	7	to	to	TO
cord-291727-4wfhuvww	284	8	use	use	VB
cord-291727-4wfhuvww	284	9	this	this	DT
cord-291727-4wfhuvww	284	10	approach	approach	NN
cord-291727-4wfhuvww	284	11	as	as	IN
cord-291727-4wfhuvww	284	12	a	a	DT
cord-291727-4wfhuvww	284	13	systematic	systematic	JJ
cord-291727-4wfhuvww	284	14	tool	tool	NN
cord-291727-4wfhuvww	284	15	for	for	IN
cord-291727-4wfhuvww	284	16	the	the	DT
cord-291727-4wfhuvww	284	17	identification	identification	NN
cord-291727-4wfhuvww	284	18	of	of	IN
cord-291727-4wfhuvww	284	19	genomic	genomic	JJ
cord-291727-4wfhuvww	284	20	out	out	IN
cord-291727-4wfhuvww	284	21	-	-	HYPH
cord-291727-4wfhuvww	284	22	of	of	IN
cord-291727-4wfhuvww	284	23	-	-	HYPH
cord-291727-4wfhuvww	284	24	frame	frame	NN
cord-291727-4wfhuvww	284	25	peptides	peptide	NNS
cord-291727-4wfhuvww	284	26	.	.	.
cord-291727-4wfhuvww	285	1	In	in	IN
cord-291727-4wfhuvww	285	2	which	which	WDT
cord-291727-4wfhuvww	285	3	cellular	cellular	JJ
cord-291727-4wfhuvww	285	4	processes	process	NNS
cord-291727-4wfhuvww	285	5	should	should	MD
cord-291727-4wfhuvww	285	6	we	-PRON-	PRP
cord-291727-4wfhuvww	285	7	expect	expect	VB
cord-291727-4wfhuvww	285	8	to	to	TO
cord-291727-4wfhuvww	285	9	see	see	VB
cord-291727-4wfhuvww	285	10	a	a	DT
cord-291727-4wfhuvww	285	11	high	high	JJ
cord-291727-4wfhuvww	285	12	abundance	abundance	NN
cord-291727-4wfhuvww	285	13	of	of	IN
cord-291727-4wfhuvww	285	14	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	285	15	proteins	protein	NNS
cord-291727-4wfhuvww	285	16	?	?	.
cord-291727-4wfhuvww	286	1	In	in	IN
cord-291727-4wfhuvww	286	2	principle	principle	NN
cord-291727-4wfhuvww	286	3	,	,	,
cord-291727-4wfhuvww	286	4	such	such	JJ
cord-291727-4wfhuvww	286	5	proteins	protein	NNS
cord-291727-4wfhuvww	286	6	might	may	MD
cord-291727-4wfhuvww	286	7	be	be	VB
cord-291727-4wfhuvww	286	8	involved	involve	VBN
cord-291727-4wfhuvww	286	9	in	in	IN
cord-291727-4wfhuvww	286	10	any	any	DT
cord-291727-4wfhuvww	286	11	cellular	cellular	JJ
cord-291727-4wfhuvww	286	12	process	process	NN
cord-291727-4wfhuvww	286	13	,	,	,
cord-291727-4wfhuvww	286	14	but	but	CC
cord-291727-4wfhuvww	286	15	may	may	MD
cord-291727-4wfhuvww	286	16	be	be	VB
cord-291727-4wfhuvww	286	17	correlated	correlate	VBN
cord-291727-4wfhuvww	286	18	with	with	IN
cord-291727-4wfhuvww	286	19	certain	certain	JJ
cord-291727-4wfhuvww	286	20	cellular	cellular	JJ
cord-291727-4wfhuvww	286	21	pathways	pathway	NNS
cord-291727-4wfhuvww	286	22	.	.	.
cord-291727-4wfhuvww	287	1	For	for	IN
cord-291727-4wfhuvww	287	2	instance	instance	NN
cord-291727-4wfhuvww	287	3	,	,	,
cord-291727-4wfhuvww	287	4	amino	amino	NN
cord-291727-4wfhuvww	287	5	acid	acid	NN
cord-291727-4wfhuvww	287	6	starvation	starvation	NN
cord-291727-4wfhuvww	287	7	can	can	MD
cord-291727-4wfhuvww	287	8	induce	induce	VB
cord-291727-4wfhuvww	287	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	287	10	in	in	IN
cord-291727-4wfhuvww	287	11	bacteria	bacteria	NNS
cord-291727-4wfhuvww	287	12	(	(	-LRB-
cord-291727-4wfhuvww	287	13	Barak	Barak	NNP
cord-291727-4wfhuvww	287	14	et	et	NNP
cord-291727-4wfhuvww	287	15	al	al	NNP
cord-291727-4wfhuvww	287	16	.	.	NNP
cord-291727-4wfhuvww	287	17	,	,	,
cord-291727-4wfhuvww	287	18	1996	1996	CD
cord-291727-4wfhuvww	287	19	)	)	-RRB-
cord-291727-4wfhuvww	287	20	.	.	.
cord-291727-4wfhuvww	288	1	One	one	CD
cord-291727-4wfhuvww	288	2	hypothesis	hypothesis	NN
cord-291727-4wfhuvww	288	3	is	be	VBZ
cord-291727-4wfhuvww	288	4	that	that	IN
cord-291727-4wfhuvww	288	5	this	this	DT
cord-291727-4wfhuvww	288	6	is	be	VBZ
cord-291727-4wfhuvww	288	7	due	due	JJ
cord-291727-4wfhuvww	288	8	to	to	IN
cord-291727-4wfhuvww	288	9	a	a	DT
cord-291727-4wfhuvww	288	10	short	short	JJ
cord-291727-4wfhuvww	288	11	supply	supply	NN
cord-291727-4wfhuvww	288	12	of	of	IN
cord-291727-4wfhuvww	288	13	amino	amino	NN
cord-291727-4wfhuvww	288	14	-	-	HYPH
cord-291727-4wfhuvww	288	15	acylated	acylate	VBN
cord-291727-4wfhuvww	288	16	tRNA	tRNA	NNP
cord-291727-4wfhuvww	288	17	as	as	IN
cord-291727-4wfhuvww	288	18	a	a	DT
cord-291727-4wfhuvww	288	19	consequence	consequence	NN
cord-291727-4wfhuvww	288	20	of	of	IN
cord-291727-4wfhuvww	288	21	amino	amino	NN
cord-291727-4wfhuvww	288	22	acid	acid	JJ
cord-291727-4wfhuvww	288	23	limitations	limitation	NNS
cord-291727-4wfhuvww	288	24	.	.	.
cord-291727-4wfhuvww	289	1	This	this	DT
cord-291727-4wfhuvww	289	2	is	be	VBZ
cord-291727-4wfhuvww	289	3	supported	support	VBN
cord-291727-4wfhuvww	289	4	by	by	IN
cord-291727-4wfhuvww	289	5	the	the	DT
cord-291727-4wfhuvww	289	6	observation	observation	NN
cord-291727-4wfhuvww	289	7	that	that	WDT
cord-291727-4wfhuvww	289	8	antizyme	antizyme	VBZ
cord-291727-4wfhuvww	289	9	expression	expression	NN
cord-291727-4wfhuvww	289	10	(	(	-LRB-
cord-291727-4wfhuvww	289	11	the	the	DT
cord-291727-4wfhuvww	289	12	+1	+1	NN
cord-291727-4wfhuvww	289	13	frame	frame	NN
cord-291727-4wfhuvww	289	14	)	)	-RRB-
cord-291727-4wfhuvww	289	15	is	be	VBZ
cord-291727-4wfhuvww	289	16	maintained	maintain	VBN
cord-291727-4wfhuvww	289	17	under	under	IN
cord-291727-4wfhuvww	289	18	conditions	condition	NNS
cord-291727-4wfhuvww	289	19	of	of	IN
cord-291727-4wfhuvww	289	20	amino	amino	NN
cord-291727-4wfhuvww	289	21	acid	acid	NN
cord-291727-4wfhuvww	289	22	starvation	starvation	NN
cord-291727-4wfhuvww	289	23	,	,	,
cord-291727-4wfhuvww	289	24	while	while	IN
cord-291727-4wfhuvww	289	25	expression	expression	NN
cord-291727-4wfhuvww	289	26	of	of	IN
cord-291727-4wfhuvww	289	27	ODC	ODC	NNP
cord-291727-4wfhuvww	289	28	(	(	-LRB-
cord-291727-4wfhuvww	289	29	the	the	DT
cord-291727-4wfhuvww	289	30	0	0	CD
cord-291727-4wfhuvww	289	31	frame	frame	NN
cord-291727-4wfhuvww	289	32	)	)	-RRB-
cord-291727-4wfhuvww	289	33	is	be	VBZ
cord-291727-4wfhuvww	289	34	reduced	reduce	VBN
cord-291727-4wfhuvww	289	35	in	in	IN
cord-291727-4wfhuvww	289	36	rat	rat	NN
cord-291727-4wfhuvww	289	37	intestinal	intestinal	JJ
cord-291727-4wfhuvww	289	38	epithelial	epithelial	JJ
cord-291727-4wfhuvww	289	39	cells	cell	NNS
cord-291727-4wfhuvww	289	40	(	(	-LRB-
cord-291727-4wfhuvww	289	41	Ray	Ray	NNP
cord-291727-4wfhuvww	289	42	et	et	NNP
cord-291727-4wfhuvww	289	43	al	al	NNP
cord-291727-4wfhuvww	289	44	.	.	NNP
cord-291727-4wfhuvww	289	45	,	,	,
cord-291727-4wfhuvww	289	46	2012	2012	CD
cord-291727-4wfhuvww	289	47	)	)	-RRB-
cord-291727-4wfhuvww	289	48	.	.	.
cord-291727-4wfhuvww	290	1	Moreover	moreover	RB
cord-291727-4wfhuvww	290	2	,	,	,
cord-291727-4wfhuvww	290	3	treatment	treatment	NN
cord-291727-4wfhuvww	290	4	with	with	IN
cord-291727-4wfhuvww	290	5	mTOR	mTOR	NNP
cord-291727-4wfhuvww	290	6	inhibitors	inhibitor	NNS
cord-291727-4wfhuvww	290	7	such	such	JJ
cord-291727-4wfhuvww	290	8	as	as	IN
cord-291727-4wfhuvww	290	9	rapamycin	rapamycin	NN
cord-291727-4wfhuvww	290	10	also	also	RB
cord-291727-4wfhuvww	290	11	reduce	reduce	VBP
cord-291727-4wfhuvww	290	12	0	0	CD
cord-291727-4wfhuvww	290	13	frame	frame	NN
cord-291727-4wfhuvww	290	14	expression	expression	NN
cord-291727-4wfhuvww	290	15	while	while	IN
cord-291727-4wfhuvww	290	16	maintaining	maintain	VBG
cord-291727-4wfhuvww	290	17	antizyme	antizyme	NNS
cord-291727-4wfhuvww	290	18	expression	expression	NN
cord-291727-4wfhuvww	290	19	.	.	.
cord-291727-4wfhuvww	291	1	One	one	PRP
cord-291727-4wfhuvww	291	2	could	could	MD
cord-291727-4wfhuvww	291	3	hypothesize	hypothesize	VB
cord-291727-4wfhuvww	291	4	that	that	IN
cord-291727-4wfhuvww	291	5	reduced	reduce	VBN
cord-291727-4wfhuvww	291	6	fidelity	fidelity	NN
cord-291727-4wfhuvww	291	7	in	in	IN
cord-291727-4wfhuvww	291	8	translation	translation	NN
cord-291727-4wfhuvww	291	9	may	may	MD
cord-291727-4wfhuvww	291	10	enhance	enhance	VB
cord-291727-4wfhuvww	291	11	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	291	12	.	.	.
cord-291727-4wfhuvww	292	1	On	on	IN
cord-291727-4wfhuvww	292	2	the	the	DT
cord-291727-4wfhuvww	292	3	other	other	JJ
cord-291727-4wfhuvww	292	4	hand	hand	NN
cord-291727-4wfhuvww	292	5	,	,	,
cord-291727-4wfhuvww	292	6	both	both	DT
cord-291727-4wfhuvww	292	7	translation	translation	NN
cord-291727-4wfhuvww	292	8	inhibition	inhibition	NN
cord-291727-4wfhuvww	292	9	and	and	CC
cord-291727-4wfhuvww	292	10	amino	amino	NN
cord-291727-4wfhuvww	292	11	acid	acid	NN
cord-291727-4wfhuvww	292	12	starvation	starvation	NN
cord-291727-4wfhuvww	292	13	are	be	VBP
cord-291727-4wfhuvww	292	14	conditions	condition	NNS
cord-291727-4wfhuvww	292	15	that	that	WDT
cord-291727-4wfhuvww	292	16	increase	increase	VBP
cord-291727-4wfhuvww	292	17	autophagy	autophagy	NN
cord-291727-4wfhuvww	292	18	in	in	IN
cord-291727-4wfhuvww	292	19	eukaryotic	eukaryotic	JJ
cord-291727-4wfhuvww	292	20	cells	cell	NNS
cord-291727-4wfhuvww	292	21	,	,	,
cord-291727-4wfhuvww	292	22	raising	raise	VBG
cord-291727-4wfhuvww	292	23	the	the	DT
cord-291727-4wfhuvww	292	24	possibility	possibility	NN
cord-291727-4wfhuvww	292	25	that	that	IN
cord-291727-4wfhuvww	292	26	the	the	DT
cord-291727-4wfhuvww	292	27	production	production	NN
cord-291727-4wfhuvww	292	28	of	of	IN
cord-291727-4wfhuvww	292	29	outof	outof	JJ
cord-291727-4wfhuvww	292	30	-	-	HYPH
cord-291727-4wfhuvww	292	31	frame	frame	NN
cord-291727-4wfhuvww	292	32	proteins	protein	NNS
cord-291727-4wfhuvww	292	33	may	may	MD
cord-291727-4wfhuvww	292	34	be	be	VB
cord-291727-4wfhuvww	292	35	functionally	functionally	RB
cord-291727-4wfhuvww	292	36	coupled	couple	VBN
cord-291727-4wfhuvww	292	37	to	to	IN
cord-291727-4wfhuvww	292	38	the	the	DT
cord-291727-4wfhuvww	292	39	regulation	regulation	NN
cord-291727-4wfhuvww	292	40	of	of	IN
cord-291727-4wfhuvww	292	41	autophagy	autophagy	NN
cord-291727-4wfhuvww	292	42	.	.	.
cord-291727-4wfhuvww	293	1	There	there	EX
cord-291727-4wfhuvww	293	2	is	be	VBZ
cord-291727-4wfhuvww	293	3	increasing	increase	VBG
cord-291727-4wfhuvww	293	4	evidence	evidence	NN
cord-291727-4wfhuvww	293	5	for	for	IN
cord-291727-4wfhuvww	293	6	an	an	DT
cord-291727-4wfhuvww	293	7	alternative	alternative	JJ
cord-291727-4wfhuvww	293	8	genome	genome	NN
cord-291727-4wfhuvww	293	9	/	/	SYM
cord-291727-4wfhuvww	293	10	proteome	proteome	NN
cord-291727-4wfhuvww	293	11	in	in	IN
cord-291727-4wfhuvww	293	12	both	both	DT
cord-291727-4wfhuvww	293	13	prokaryotes	prokaryote	NNS
cord-291727-4wfhuvww	293	14	and	and	CC
cord-291727-4wfhuvww	293	15	eukaryotes	eukaryote	NNS
cord-291727-4wfhuvww	293	16	,	,	,
cord-291727-4wfhuvww	293	17	reflecting	reflect	VBG
cord-291727-4wfhuvww	293	18	programmed	program	VBN
cord-291727-4wfhuvww	293	19	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	293	20	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	293	21	.	.	.
cord-291727-4wfhuvww	294	1	It	-PRON-	PRP
cord-291727-4wfhuvww	294	2	is	be	VBZ
cord-291727-4wfhuvww	294	3	likely	likely	JJ
cord-291727-4wfhuvww	294	4	that	that	IN
cord-291727-4wfhuvww	294	5	a	a	DT
cord-291727-4wfhuvww	294	6	combination	combination	NN
cord-291727-4wfhuvww	294	7	of	of	IN
cord-291727-4wfhuvww	294	8	computational	computational	JJ
cord-291727-4wfhuvww	294	9	,	,	,
cord-291727-4wfhuvww	294	10	experimental	experimental	JJ
cord-291727-4wfhuvww	294	11	,	,	,
cord-291727-4wfhuvww	294	12	genomic	genomic	JJ
cord-291727-4wfhuvww	294	13	,	,	,
cord-291727-4wfhuvww	294	14	and	and	CC
cord-291727-4wfhuvww	294	15	proteomic	proteomic	JJ
cord-291727-4wfhuvww	294	16	methods	method	NNS
cord-291727-4wfhuvww	294	17	will	will	MD
cord-291727-4wfhuvww	294	18	be	be	VB
cord-291727-4wfhuvww	294	19	needed	need	VBN
cord-291727-4wfhuvww	294	20	to	to	TO
cord-291727-4wfhuvww	294	21	determine	determine	VB
cord-291727-4wfhuvww	294	22	the	the	DT
cord-291727-4wfhuvww	294	23	entire	entire	JJ
cord-291727-4wfhuvww	294	24	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	294	25	proteome	proteome	NN
cord-291727-4wfhuvww	294	26	,	,	,
cord-291727-4wfhuvww	294	27	as	as	IN
cord-291727-4wfhuvww	294	28	required	require	VBN
cord-291727-4wfhuvww	294	29	to	to	TO
cord-291727-4wfhuvww	294	30	understand	understand	VB
cord-291727-4wfhuvww	294	31	fully	fully	RB
cord-291727-4wfhuvww	294	32	gene	gene	VB
cord-291727-4wfhuvww	294	33	expression	expression	NN
cord-291727-4wfhuvww	294	34	in	in	IN
cord-291727-4wfhuvww	294	35	any	any	DT
cord-291727-4wfhuvww	294	36	organism	organism	NN
cord-291727-4wfhuvww	294	37	.	.	.
cord-291727-4wfhuvww	295	1	We	-PRON-	PRP
cord-291727-4wfhuvww	295	2	need	need	VBP
cord-291727-4wfhuvww	295	3	to	to	TO
cord-291727-4wfhuvww	295	4	identify	identify	VB
cord-291727-4wfhuvww	295	5	the	the	DT
cord-291727-4wfhuvww	295	6	frameshift	frameshift	NN
cord-291727-4wfhuvww	295	7	motifs	motif	NNS
cord-291727-4wfhuvww	295	8	that	that	WDT
cord-291727-4wfhuvww	295	9	enable	enable	VBP
cord-291727-4wfhuvww	295	10	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	295	11	,	,	,
cord-291727-4wfhuvww	295	12	as	as	RB
cord-291727-4wfhuvww	295	13	well	well	RB
cord-291727-4wfhuvww	295	14	as	as	IN
cord-291727-4wfhuvww	295	15	all	all	PDT
cord-291727-4wfhuvww	295	16	the	the	DT
cord-291727-4wfhuvww	295	17	genes	gene	NNS
cord-291727-4wfhuvww	295	18	that	that	WDT
cord-291727-4wfhuvww	295	19	produce	produce	VBP
cord-291727-4wfhuvww	295	20	out	out	RP
cord-291727-4wfhuvww	295	21	-	-	HYPH
cord-291727-4wfhuvww	295	22	of	of	IN
cord-291727-4wfhuvww	295	23	-	-	HYPH
cord-291727-4wfhuvww	295	24	frame	frame	NN
cord-291727-4wfhuvww	295	25	peptides	peptide	NNS
cord-291727-4wfhuvww	295	26	.	.	.
cord-291727-4wfhuvww	296	1	Finally	finally	RB
cord-291727-4wfhuvww	296	2	,	,	,
cord-291727-4wfhuvww	296	3	as	as	IN
cord-291727-4wfhuvww	296	4	a	a	DT
cord-291727-4wfhuvww	296	5	low	low	JJ
cord-291727-4wfhuvww	296	6	level	level	NN
cord-291727-4wfhuvww	296	7	of	of	IN
cord-291727-4wfhuvww	296	8	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	296	9	can	can	MD
cord-291727-4wfhuvww	296	10	be	be	VB
cord-291727-4wfhuvww	296	11	considered	consider	VBN
cord-291727-4wfhuvww	296	12	"	"	``
cord-291727-4wfhuvww	296	13	biological	biological	JJ
cord-291727-4wfhuvww	296	14	noise	noise	NN
cord-291727-4wfhuvww	296	15	,	,	,
cord-291727-4wfhuvww	296	16	"	"	``
cord-291727-4wfhuvww	296	17	we	-PRON-	PRP
cord-291727-4wfhuvww	296	18	need	need	VBP
cord-291727-4wfhuvww	296	19	to	to	TO
cord-291727-4wfhuvww	296	20	determine	determine	VB
cord-291727-4wfhuvww	296	21	the	the	DT
cord-291727-4wfhuvww	296	22	physiological	physiological	JJ
cord-291727-4wfhuvww	296	23	relevance	relevance	NN
cord-291727-4wfhuvww	296	24	of	of	IN
cord-291727-4wfhuvww	296	25	these	these	DT
cord-291727-4wfhuvww	296	26	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	296	27	proteins	protein	NNS
cord-291727-4wfhuvww	296	28	.	.	.
cord-291727-4wfhuvww	297	1	Following	follow	VBG
cord-291727-4wfhuvww	297	2	the	the	DT
cord-291727-4wfhuvww	297	3	intersubunit	intersubunit	JJ
cord-291727-4wfhuvww	297	4	conformation	conformation	NN
cord-291727-4wfhuvww	297	5	of	of	IN
cord-291727-4wfhuvww	297	6	the	the	DT
cord-291727-4wfhuvww	297	7	ribosome	ribosome	NN
cord-291727-4wfhuvww	297	8	during	during	IN
cord-291727-4wfhuvww	297	9	translation	translation	NN
cord-291727-4wfhuvww	297	10	in	in	IN
cord-291727-4wfhuvww	297	11	real	real	JJ
cord-291727-4wfhuvww	297	12	time	time	NN
cord-291727-4wfhuvww	298	1	Readthrough	Readthrough	NNP
cord-291727-4wfhuvww	298	2	strategies	strategy	NNS
cord-291727-4wfhuvww	298	3	for	for	IN
cord-291727-4wfhuvww	298	4	stop	stop	NN
cord-291727-4wfhuvww	298	5	codons	codon	NNS
cord-291727-4wfhuvww	298	6	in	in	IN
cord-291727-4wfhuvww	298	7	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	298	8	muscular	muscular	JJ
cord-291727-4wfhuvww	298	9	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	299	1	On	on	IN
cord-291727-4wfhuvww	299	2	the	the	DT
cord-291727-4wfhuvww	299	3	mechanism	mechanism	NN
cord-291727-4wfhuvww	299	4	of	of	IN
cord-291727-4wfhuvww	299	5	leftward	leftward	NNP
cord-291727-4wfhuvww	299	6	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	299	7	at	at	IN
cord-291727-4wfhuvww	299	8	several	several	JJ
cord-291727-4wfhuvww	299	9	hungry	hungry	JJ
cord-291727-4wfhuvww	299	10	codons	codon	NNS
cord-291727-4wfhuvww	299	11	RECODE	RECODE	NNP
cord-291727-4wfhuvww	299	12	:	:	:
cord-291727-4wfhuvww	299	13	a	a	DT
cord-291727-4wfhuvww	299	14	database	database	NN
cord-291727-4wfhuvww	299	15	of	of	IN
cord-291727-4wfhuvww	299	16	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	299	17	,	,	,
cord-291727-4wfhuvww	299	18	bypassing	bypass	VBG
cord-291727-4wfhuvww	299	19	and	and	CC
cord-291727-4wfhuvww	299	20	codon	codon	NN
cord-291727-4wfhuvww	299	21	redefinition	redefinition	NN
cord-291727-4wfhuvww	299	22	utilized	utilize	VBN
cord-291727-4wfhuvww	299	23	for	for	IN
cord-291727-4wfhuvww	299	24	gene	gene	NN
cord-291727-4wfhuvww	299	25	expression	expression	NN
cord-291727-4wfhuvww	299	26	Programmed	program	VBD
cord-291727-4wfhuvww	299	27	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	299	28	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	299	29	in	in	IN
cord-291727-4wfhuvww	299	30	the	the	DT
cord-291727-4wfhuvww	299	31	expression	expression	NN
cord-291727-4wfhuvww	299	32	of	of	IN
cord-291727-4wfhuvww	299	33	the	the	DT
cord-291727-4wfhuvww	299	34	regulator	regulator	NN
cord-291727-4wfhuvww	299	35	of	of	IN
cord-291727-4wfhuvww	299	36	intestinal	intestinal	JJ
cord-291727-4wfhuvww	299	37	stem	stem	NN
cord-291727-4wfhuvww	299	38	cell	cell	NN
cord-291727-4wfhuvww	299	39	proliferation	proliferation	NN
cord-291727-4wfhuvww	299	40	,	,	,
cord-291727-4wfhuvww	299	41	adenomatous	adenomatous	JJ
cord-291727-4wfhuvww	299	42	polyposis	polyposis	NN
cord-291727-4wfhuvww	299	43	coli	coli	NNS
cord-291727-4wfhuvww	299	44	(	(	-LRB-
cord-291727-4wfhuvww	299	45	APC	APC	NNP
cord-291727-4wfhuvww	299	46	)	)	-RRB-
cord-291727-4wfhuvww	299	47	ARFA	ARFA	NNP
cord-291727-4wfhuvww	299	48	:	:	:
cord-291727-4wfhuvww	299	49	a	a	DT
cord-291727-4wfhuvww	299	50	program	program	NN
cord-291727-4wfhuvww	299	51	for	for	IN
cord-291727-4wfhuvww	299	52	annotating	annotate	VBG
cord-291727-4wfhuvww	299	53	bacterial	bacterial	JJ
cord-291727-4wfhuvww	299	54	release	release	NN
cord-291727-4wfhuvww	299	55	factor	factor	NN
cord-291727-4wfhuvww	299	56	genes	gene	NNS
cord-291727-4wfhuvww	299	57	,	,	,
cord-291727-4wfhuvww	299	58	including	include	VBG
cord-291727-4wfhuvww	299	59	prediction	prediction	NN
cord-291727-4wfhuvww	299	60	of	of	IN
cord-291727-4wfhuvww	299	61	programmed	program	VBN
cord-291727-4wfhuvww	299	62	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	299	63	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	299	64	Recode-2	Recode-2	NNP
cord-291727-4wfhuvww	299	65	:	:	:
cord-291727-4wfhuvww	299	66	new	new	JJ
cord-291727-4wfhuvww	299	67	design	design	NN
cord-291727-4wfhuvww	299	68	,	,	,
cord-291727-4wfhuvww	299	69	new	new	JJ
cord-291727-4wfhuvww	299	70	search	search	NN
cord-291727-4wfhuvww	299	71	tools	tool	NNS
cord-291727-4wfhuvww	299	72	,	,	,
cord-291727-4wfhuvww	299	73	and	and	CC
cord-291727-4wfhuvww	299	74	many	many	JJ
cord-291727-4wfhuvww	299	75	more	more	JJR
cord-291727-4wfhuvww	299	76	genes	gene	NNS
cord-291727-4wfhuvww	299	77	Ornithine	Ornithine	NNP
cord-291727-4wfhuvww	299	78	decarboxylase	decarboxylase	NN
cord-291727-4wfhuvww	299	79	antizyme	antizyme	NNS
cord-291727-4wfhuvww	299	80	finder	finder	NN
cord-291727-4wfhuvww	299	81	(	(	-LRB-
cord-291727-4wfhuvww	299	82	OAF	OAF	NNP
cord-291727-4wfhuvww	299	83	)	)	-RRB-
cord-291727-4wfhuvww	299	84	:	:	:
cord-291727-4wfhuvww	299	85	fast	fast	JJ
cord-291727-4wfhuvww	299	86	and	and	CC
cord-291727-4wfhuvww	299	87	reliable	reliable	JJ
cord-291727-4wfhuvww	299	88	detection	detection	NN
cord-291727-4wfhuvww	299	89	of	of	IN
cord-291727-4wfhuvww	299	90	antizymes	antizymes	NNP
cord-291727-4wfhuvww	299	91	with	with	IN
cord-291727-4wfhuvww	299	92	frameshifts	frameshift	NNS
cord-291727-4wfhuvww	299	93	in	in	IN
cord-291727-4wfhuvww	299	94	mRNAs	mrnas	CD
cord-291727-4wfhuvww	299	95	Endogenous	endogenous	JJ
cord-291727-4wfhuvww	299	96	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	299	97	frameshift	frameshift	NN
cord-291727-4wfhuvww	299	98	signals	signal	NNS
cord-291727-4wfhuvww	299	99	operate	operate	VBP
cord-291727-4wfhuvww	299	100	as	as	IN
cord-291727-4wfhuvww	299	101	mRNA	mrna	NN
cord-291727-4wfhuvww	299	102	destabilizing	destabilize	VBG
cord-291727-4wfhuvww	299	103	elements	element	NNS
cord-291727-4wfhuvww	299	104	through	through	IN
cord-291727-4wfhuvww	299	105	at	at	RB
cord-291727-4wfhuvww	299	106	least	least	RBS
cord-291727-4wfhuvww	299	107	two	two	CD
cord-291727-4wfhuvww	299	108	molecular	molecular	JJ
cord-291727-4wfhuvww	299	109	pathways	pathway	NNS
cord-291727-4wfhuvww	299	110	in	in	IN
cord-291727-4wfhuvww	299	111	yeast	yeast	NN
cord-291727-4wfhuvww	299	112	Evolution	evolution	NN
cord-291727-4wfhuvww	299	113	and	and	CC
cord-291727-4wfhuvww	299	114	multilevel	multilevel	JJ
cord-291727-4wfhuvww	299	115	optimization	optimization	NN
cord-291727-4wfhuvww	299	116	of	of	IN
cord-291727-4wfhuvww	299	117	the	the	DT
cord-291727-4wfhuvww	299	118	genetic	genetic	JJ
cord-291727-4wfhuvww	299	119	code	code	NN
cord-291727-4wfhuvww	299	120	Targeting	Targeting	NNP
cord-291727-4wfhuvww	299	121	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	299	122	in	in	IN
cord-291727-4wfhuvww	299	123	the	the	DT
cord-291727-4wfhuvww	299	124	human	human	JJ
cord-291727-4wfhuvww	299	125	immunodeficiency	immunodeficiency	NN
cord-291727-4wfhuvww	299	126	virus	virus	NN
cord-291727-4wfhuvww	300	1	Programmed	program	VBN
cord-291727-4wfhuvww	300	2	ribosomal	ribosomal	NN
cord-291727-4wfhuvww	300	3	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	300	4	in	in	IN
cord-291727-4wfhuvww	300	5	HIV-1	HIV-1	NNP
cord-291727-4wfhuvww	300	6	and	and	CC
cord-291727-4wfhuvww	300	7	the	the	DT
cord-291727-4wfhuvww	300	8	SARS	SARS	NNP
cord-291727-4wfhuvww	300	9	-	-	HYPH
cord-291727-4wfhuvww	300	10	CoV	CoV	NNP
cord-291727-4wfhuvww	300	11	A	a	DT
cord-291727-4wfhuvww	300	12	homogeneous	homogeneous	JJ
cord-291727-4wfhuvww	300	13	cell	cell	NN
cord-291727-4wfhuvww	300	14	-	-	HYPH
cord-291727-4wfhuvww	300	15	based	base	VBN
cord-291727-4wfhuvww	300	16	bicistronic	bicistronic	JJ
cord-291727-4wfhuvww	300	17	fluorescence	fluorescence	NN
cord-291727-4wfhuvww	300	18	assay	assay	NN
cord-291727-4wfhuvww	300	19	for	for	IN
cord-291727-4wfhuvww	300	20	high	high	JJ
cord-291727-4wfhuvww	300	21	-	-	HYPH
cord-291727-4wfhuvww	300	22	throughput	throughput	NN
cord-291727-4wfhuvww	300	23	identification	identification	NN
cord-291727-4wfhuvww	300	24	of	of	IN
cord-291727-4wfhuvww	300	25	drugs	drug	NNS
cord-291727-4wfhuvww	300	26	that	that	WDT
cord-291727-4wfhuvww	300	27	perturb	perturb	VBP
cord-291727-4wfhuvww	300	28	viral	viral	JJ
cord-291727-4wfhuvww	300	29	gene	gene	NN
cord-291727-4wfhuvww	300	30	recoding	recoding	NN
cord-291727-4wfhuvww	300	31	and	and	CC
cord-291727-4wfhuvww	300	32	read	read	VB
cord-291727-4wfhuvww	300	33	-	-	HYPH
cord-291727-4wfhuvww	300	34	through	through	NN
cord-291727-4wfhuvww	300	35	of	of	IN
cord-291727-4wfhuvww	300	36	nonsense	nonsense	NN
cord-291727-4wfhuvww	300	37	stop	stop	NN
cord-291727-4wfhuvww	300	38	codons	codon	NNS
cord-291727-4wfhuvww	300	39	Triplex	Triplex	NNP
cord-291727-4wfhuvww	300	40	structures	structure	NNS
cord-291727-4wfhuvww	300	41	in	in	IN
cord-291727-4wfhuvww	300	42	an	an	DT
cord-291727-4wfhuvww	300	43	RNA	RNA	NNP
cord-291727-4wfhuvww	300	44	pseudoknot	pseudoknot	NN
cord-291727-4wfhuvww	300	45	enhance	enhance	VB
cord-291727-4wfhuvww	300	46	mechanical	mechanical	JJ
cord-291727-4wfhuvww	300	47	stability	stability	NN
cord-291727-4wfhuvww	300	48	and	and	CC
cord-291727-4wfhuvww	300	49	increase	increase	VB
cord-291727-4wfhuvww	300	50	efficiency	efficiency	NN
cord-291727-4wfhuvww	300	51	of	of	IN
cord-291727-4wfhuvww	300	52	−1	−1	NNP
cord-291727-4wfhuvww	300	53	ribosomal	ribosomal	NN
cord-291727-4wfhuvww	301	1	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	301	2	A	a	DT
cord-291727-4wfhuvww	301	3	characteristic	characteristic	JJ
cord-291727-4wfhuvww	301	4	bent	bent	JJ
cord-291727-4wfhuvww	301	5	conformation	conformation	NN
cord-291727-4wfhuvww	301	6	of	of	IN
cord-291727-4wfhuvww	301	7	RNA	RNA	NNP
cord-291727-4wfhuvww	301	8	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	301	9	promotes	promote	VBZ
cord-291727-4wfhuvww	301	10	−1	−1	NNP
cord-291727-4wfhuvww	301	11	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	301	12	during	during	IN
cord-291727-4wfhuvww	301	13	translation	translation	NN
cord-291727-4wfhuvww	301	14	of	of	IN
cord-291727-4wfhuvww	301	15	retroviral	retroviral	JJ
cord-291727-4wfhuvww	301	16	RNA	RNA	NNP
cord-291727-4wfhuvww	301	17	Exon	Exon	NNP
cord-291727-4wfhuvww	301	18	skipping	skip	VBG
cord-291727-4wfhuvww	301	19	and	and	CC
cord-291727-4wfhuvww	301	20	dystrophin	dystrophin	NN
cord-291727-4wfhuvww	301	21	restoration	restoration	NN
cord-291727-4wfhuvww	301	22	in	in	IN
cord-291727-4wfhuvww	301	23	patients	patient	NNS
cord-291727-4wfhuvww	301	24	with	with	IN
cord-291727-4wfhuvww	301	25	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	301	26	muscular	muscular	JJ
cord-291727-4wfhuvww	301	27	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	301	28	after	after	IN
cord-291727-4wfhuvww	301	29	systemic	systemic	JJ
cord-291727-4wfhuvww	301	30	phosphorodiamidate	phosphorodiamidate	NNP
cord-291727-4wfhuvww	301	31	morpholino	morpholino	NNP
cord-291727-4wfhuvww	301	32	oligomer	oligomer	NNP
cord-291727-4wfhuvww	301	33	treatment	treatment	NN
cord-291727-4wfhuvww	301	34	:	:	:
cord-291727-4wfhuvww	301	35	an	an	DT
cord-291727-4wfhuvww	301	36	open	open	JJ
cord-291727-4wfhuvww	301	37	-	-	HYPH
cord-291727-4wfhuvww	301	38	label	label	NN
cord-291727-4wfhuvww	301	39	,	,	,
cord-291727-4wfhuvww	301	40	phase	phase	NN
cord-291727-4wfhuvww	301	41	2	2	CD
cord-291727-4wfhuvww	301	42	,	,	,
cord-291727-4wfhuvww	301	43	dose	dose	NN
cord-291727-4wfhuvww	301	44	-	-	HYPH
cord-291727-4wfhuvww	301	45	escalation	escalation	NN
cord-291727-4wfhuvww	301	46	study	study	NN
cord-291727-4wfhuvww	301	47	Mammalian	mammalian	JJ
cord-291727-4wfhuvww	301	48	gene	gene	NN
cord-291727-4wfhuvww	301	49	PEG10	PEG10	NNP
cord-291727-4wfhuvww	301	50	expresses	express	VBZ
cord-291727-4wfhuvww	301	51	two	two	CD
cord-291727-4wfhuvww	301	52	reading	read	VBG
cord-291727-4wfhuvww	301	53	frames	frame	NNS
cord-291727-4wfhuvww	301	54	by	by	IN
cord-291727-4wfhuvww	301	55	high	high	JJ
cord-291727-4wfhuvww	301	56	efficiency	efficiency	NN
cord-291727-4wfhuvww	301	57	−1	−1	NNP
cord-291727-4wfhuvww	301	58	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	301	59	in	in	IN
cord-291727-4wfhuvww	301	60	embryonic	embryonic	JJ
cord-291727-4wfhuvww	301	61	Control	Control	NNP
cord-291727-4wfhuvww	301	62	of	of	IN
cord-291727-4wfhuvww	301	63	gene	gene	NN
cord-291727-4wfhuvww	301	64	expression	expression	NN
cord-291727-4wfhuvww	301	65	by	by	IN
cord-291727-4wfhuvww	301	66	translational	translational	JJ
cord-291727-4wfhuvww	301	67	recoding	recode	VBG
cord-291727-4wfhuvww	301	68	Mechanisms	mechanism	NNS
cord-291727-4wfhuvww	301	69	and	and	CC
cord-291727-4wfhuvww	301	70	implications	implication	NNS
cord-291727-4wfhuvww	301	71	of	of	IN
cord-291727-4wfhuvww	301	72	programmed	program	VBN
cord-291727-4wfhuvww	301	73	translational	translational	JJ
cord-291727-4wfhuvww	301	74	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	301	75	An	an	DT
cord-291727-4wfhuvww	301	76	algorithm	algorithm	NN
cord-291727-4wfhuvww	301	77	for	for	IN
cord-291727-4wfhuvww	301	78	computing	compute	VBG
cord-291727-4wfhuvww	301	79	nucleic	nucleic	JJ
cord-291727-4wfhuvww	301	80	acid	acid	NN
cord-291727-4wfhuvww	301	81	base	base	NN
cord-291727-4wfhuvww	301	82	-	-	HYPH
cord-291727-4wfhuvww	301	83	pairing	pair	VBG
cord-291727-4wfhuvww	301	84	probabilities	probability	NNS
cord-291727-4wfhuvww	301	85	including	include	VBG
cord-291727-4wfhuvww	301	86	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	301	87	Decreasing	decrease	VBG
cord-291727-4wfhuvww	301	88	the	the	DT
cord-291727-4wfhuvww	301	89	frameshift	frameshift	NN
cord-291727-4wfhuvww	301	90	efficiency	efficiency	NN
cord-291727-4wfhuvww	301	91	translates	translate	VBZ
cord-291727-4wfhuvww	301	92	into	into	IN
cord-291727-4wfhuvww	301	93	an	an	DT
cord-291727-4wfhuvww	301	94	equivalent	equivalent	JJ
cord-291727-4wfhuvww	301	95	reduction	reduction	NN
cord-291727-4wfhuvww	301	96	of	of	IN
cord-291727-4wfhuvww	301	97	the	the	DT
cord-291727-4wfhuvww	301	98	replication	replication	NN
cord-291727-4wfhuvww	301	99	of	of	IN
cord-291727-4wfhuvww	301	100	the	the	DT
cord-291727-4wfhuvww	301	101	human	human	JJ
cord-291727-4wfhuvww	301	102	immunodeficiency	immunodeficiency	NN
cord-291727-4wfhuvww	301	103	virus	virus	NN
cord-291727-4wfhuvww	301	104	type	type	NN
cord-291727-4wfhuvww	301	105	1	1	CD
cord-291727-4wfhuvww	301	106	Detecting	detect	VBG
cord-291727-4wfhuvww	301	107	overlapping	overlap	VBG
cord-291727-4wfhuvww	301	108	coding	coding	NN
cord-291727-4wfhuvww	301	109	sequences	sequence	NNS
cord-291727-4wfhuvww	301	110	in	in	IN
cord-291727-4wfhuvww	301	111	virus	virus	NN
cord-291727-4wfhuvww	301	112	genomes	genome	NNS
cord-291727-4wfhuvww	302	1	The	the	DT
cord-291727-4wfhuvww	302	2	presence	presence	NN
cord-291727-4wfhuvww	302	3	of	of	IN
cord-291727-4wfhuvww	302	4	the	the	DT
cord-291727-4wfhuvww	302	5	TAR	TAR	NNP
cord-291727-4wfhuvww	302	6	RNA	RNA	NNP
cord-291727-4wfhuvww	302	7	structure	structure	NN
cord-291727-4wfhuvww	302	8	alters	alter	VBZ
cord-291727-4wfhuvww	302	9	the	the	DT
cord-291727-4wfhuvww	302	10	programmed	program	VBN
cord-291727-4wfhuvww	302	11	−1	−1	NNP
cord-291727-4wfhuvww	302	12	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	302	13	frameshift	frameshift	NN
cord-291727-4wfhuvww	302	14	efficiency	efficiency	NN
cord-291727-4wfhuvww	302	15	of	of	IN
cord-291727-4wfhuvww	302	16	the	the	DT
cord-291727-4wfhuvww	302	17	human	human	JJ
cord-291727-4wfhuvww	302	18	immunodeficiency	immunodeficiency	NN
cord-291727-4wfhuvww	302	19	virus	virus	NN
cord-291727-4wfhuvww	302	20	type	type	NN
cord-291727-4wfhuvww	302	21	1	1	CD
cord-291727-4wfhuvww	302	22	(	(	-LRB-
cord-291727-4wfhuvww	302	23	HIV-1	HIV-1	NNP
cord-291727-4wfhuvww	302	24	)	)	-RRB-
cord-291727-4wfhuvww	302	25	by	by	IN
cord-291727-4wfhuvww	302	26	modifying	modify	VBG
cord-291727-4wfhuvww	302	27	the	the	DT
cord-291727-4wfhuvww	302	28	rate	rate	NN
cord-291727-4wfhuvww	302	29	of	of	IN
cord-291727-4wfhuvww	302	30	translation	translation	NN
cord-291727-4wfhuvww	302	31	initiation	initiation	NN
cord-291727-4wfhuvww	302	32	A	a	DT
cord-291727-4wfhuvww	302	33	dualluciferase	dualluciferase	NN
cord-291727-4wfhuvww	302	34	reporter	reporter	NN
cord-291727-4wfhuvww	302	35	system	system	NN
cord-291727-4wfhuvww	302	36	for	for	IN
cord-291727-4wfhuvww	302	37	studying	study	VBG
cord-291727-4wfhuvww	302	38	recoding	recode	VBG
cord-291727-4wfhuvww	302	39	signals	signal	NNS
cord-291727-4wfhuvww	303	1	Expression	expression	NN
cord-291727-4wfhuvww	303	2	levels	level	NNS
cord-291727-4wfhuvww	303	3	influence	influence	NN
cord-291727-4wfhuvww	303	4	ribosomal	ribosomal	NN
cord-291727-4wfhuvww	303	5	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	303	6	at	at	IN
cord-291727-4wfhuvww	303	7	the	the	DT
cord-291727-4wfhuvww	303	8	tandem	tandem	JJ
cord-291727-4wfhuvww	303	9	rare	rare	JJ
cord-291727-4wfhuvww	303	10	arginine	arginine	NN
cord-291727-4wfhuvww	303	11	codons	codon	NNS
cord-291727-4wfhuvww	303	12	AGG_AGG	agg_agg	CD
cord-291727-4wfhuvww	303	13	and	and	CC
cord-291727-4wfhuvww	303	14	AGA_AGA	AGA_AGA	NNS
cord-291727-4wfhuvww	303	15	in	in	IN
cord-291727-4wfhuvww	303	16	Escherichia	Escherichia	NNP
cord-291727-4wfhuvww	303	17	coli	coli	VBZ
cord-291727-4wfhuvww	303	18	Identification	identification	NN
cord-291727-4wfhuvww	303	19	of	of	IN
cord-291727-4wfhuvww	303	20	putative	putative	JJ
cord-291727-4wfhuvww	303	21	programmed	programmed	JJ
cord-291727-4wfhuvww	303	22	−1	−1	NNP
cord-291727-4wfhuvww	303	23	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	303	24	frameshift	frameshift	NN
cord-291727-4wfhuvww	303	25	signals	signal	NNS
cord-291727-4wfhuvww	303	26	in	in	IN
cord-291727-4wfhuvww	303	27	large	large	JJ
cord-291727-4wfhuvww	303	28	DNA	dna	NN
cord-291727-4wfhuvww	303	29	databases	database	NNS
cord-291727-4wfhuvww	303	30	Correlation	correlation	NN
cord-291727-4wfhuvww	303	31	between	between	IN
cord-291727-4wfhuvww	303	32	mechanical	mechanical	JJ
cord-291727-4wfhuvww	303	33	strength	strength	NN
cord-291727-4wfhuvww	303	34	of	of	IN
cord-291727-4wfhuvww	303	35	messenger	messenger	NN
cord-291727-4wfhuvww	303	36	RNA	RNA	NNP
cord-291727-4wfhuvww	303	37	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	303	38	and	and	CC
cord-291727-4wfhuvww	303	39	ribosomal	ribosomal	NN
cord-291727-4wfhuvww	304	1	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	304	2	An	an	DT
cord-291727-4wfhuvww	304	3	in	in	IN
cord-291727-4wfhuvww	304	4	vivo	vivo	NN
cord-291727-4wfhuvww	304	5	dual	dual	JJ
cord-291727-4wfhuvww	304	6	-	-	HYPH
cord-291727-4wfhuvww	304	7	luciferase	luciferase	NN
cord-291727-4wfhuvww	304	8	assay	assay	NN
cord-291727-4wfhuvww	304	9	system	system	NN
cord-291727-4wfhuvww	304	10	for	for	IN
cord-291727-4wfhuvww	304	11	studying	study	VBG
cord-291727-4wfhuvww	304	12	translational	translational	JJ
cord-291727-4wfhuvww	304	13	recoding	recoding	NN
cord-291727-4wfhuvww	304	14	in	in	IN
cord-291727-4wfhuvww	304	15	the	the	DT
cord-291727-4wfhuvww	304	16	yeast	yeast	NN
cord-291727-4wfhuvww	304	17	Saccharomyces	saccharomyce	NNS
cord-291727-4wfhuvww	304	18	cerevisiae	cerevisiae	VBZ
cord-291727-4wfhuvww	304	19	Creation	creation	NN
cord-291727-4wfhuvww	304	20	and	and	CC
cord-291727-4wfhuvww	304	21	disruption	disruption	NN
cord-291727-4wfhuvww	304	22	of	of	IN
cord-291727-4wfhuvww	304	23	protein	protein	NN
cord-291727-4wfhuvww	304	24	features	feature	NNS
cord-291727-4wfhuvww	304	25	by	by	IN
cord-291727-4wfhuvww	304	26	alternative	alternative	JJ
cord-291727-4wfhuvww	304	27	splicing	splicing	NN
cord-291727-4wfhuvww	304	28	-a	-a	HYPH
cord-291727-4wfhuvww	304	29	novel	novel	NN
cord-291727-4wfhuvww	304	30	mechanism	mechanism	NN
cord-291727-4wfhuvww	304	31	to	to	TO
cord-291727-4wfhuvww	304	32	modulate	modulate	VB
cord-291727-4wfhuvww	304	33	function	function	NN
cord-291727-4wfhuvww	305	1	An	an	DT
cord-291727-4wfhuvww	305	2	unappreciated	unappreciated	JJ
cord-291727-4wfhuvww	305	3	role	role	NN
cord-291727-4wfhuvww	305	4	for	for	IN
cord-291727-4wfhuvww	305	5	RNA	RNA	NNP
cord-291727-4wfhuvww	305	6	surveillance	surveillance	NN
cord-291727-4wfhuvww	305	7	Genome	genome	NN
cord-291727-4wfhuvww	305	8	-	-	HYPH
cord-291727-4wfhuvww	305	9	wide	wide	JJ
cord-291727-4wfhuvww	305	10	analysis	analysis	NN
cord-291727-4wfhuvww	305	11	in	in	IN
cord-291727-4wfhuvww	305	12	vivo	vivo	NN
cord-291727-4wfhuvww	305	13	of	of	IN
cord-291727-4wfhuvww	305	14	translation	translation	NN
cord-291727-4wfhuvww	305	15	with	with	IN
cord-291727-4wfhuvww	305	16	nucleotide	nucleotide	JJ
cord-291727-4wfhuvww	305	17	resolution	resolution	NN
cord-291727-4wfhuvww	305	18	using	use	VBG
cord-291727-4wfhuvww	305	19	ribosome	ribosome	NN
cord-291727-4wfhuvww	305	20	profiling	profile	VBG
cord-291727-4wfhuvww	305	21	Ribosome	Ribosome	NNP
cord-291727-4wfhuvww	305	22	profiling	profiling	NN
cord-291727-4wfhuvww	305	23	of	of	IN
cord-291727-4wfhuvww	305	24	mouse	mouse	NN
cord-291727-4wfhuvww	305	25	embryonic	embryonic	JJ
cord-291727-4wfhuvww	305	26	stem	stem	NN
cord-291727-4wfhuvww	305	27	cells	cell	NNS
cord-291727-4wfhuvww	305	28	reveals	reveal	VBZ
cord-291727-4wfhuvww	305	29	the	the	DT
cord-291727-4wfhuvww	305	30	complexity	complexity	NN
cord-291727-4wfhuvww	305	31	and	and	CC
cord-291727-4wfhuvww	305	32	dynamics	dynamic	NNS
cord-291727-4wfhuvww	305	33	of	of	IN
cord-291727-4wfhuvww	305	34	mammalian	mammalian	JJ
cord-291727-4wfhuvww	305	35	proteomes	proteome	NNS
cord-291727-4wfhuvww	305	36	Antizyme	Antizyme	NNP
cord-291727-4wfhuvww	305	37	expression	expression	NN
cord-291727-4wfhuvww	305	38	:	:	:
cord-291727-4wfhuvww	305	39	a	a	DT
cord-291727-4wfhuvww	305	40	subversion	subversion	NN
cord-291727-4wfhuvww	305	41	of	of	IN
cord-291727-4wfhuvww	305	42	triplet	triplet	NN
cord-291727-4wfhuvww	305	43	decoding	decoding	NN
cord-291727-4wfhuvww	305	44	,	,	,
cord-291727-4wfhuvww	305	45	which	which	WDT
cord-291727-4wfhuvww	305	46	is	be	VBZ
cord-291727-4wfhuvww	305	47	remarkably	remarkably	RB
cord-291727-4wfhuvww	305	48	conserved	conserve	VBN
cord-291727-4wfhuvww	305	49	by	by	IN
cord-291727-4wfhuvww	305	50	evolution	evolution	NN
cord-291727-4wfhuvww	305	51	,	,	,
cord-291727-4wfhuvww	305	52	is	be	VBZ
cord-291727-4wfhuvww	305	53	a	a	DT
cord-291727-4wfhuvww	305	54	sensor	sensor	NN
cord-291727-4wfhuvww	305	55	for	for	IN
cord-291727-4wfhuvww	305	56	an	an	DT
cord-291727-4wfhuvww	305	57	autoregulatory	autoregulatory	NNP
cord-291727-4wfhuvww	305	58	circuit	circuit	NN
cord-291727-4wfhuvww	305	59	Conservation	Conservation	NNP
cord-291727-4wfhuvww	305	60	of	of	IN
cord-291727-4wfhuvww	305	61	polyamine	polyamine	NN
cord-291727-4wfhuvww	305	62	regulation	regulation	NN
cord-291727-4wfhuvww	305	63	by	by	IN
cord-291727-4wfhuvww	305	64	translational	translational	JJ
cord-291727-4wfhuvww	305	65	frameshifting	frameshifting	NN
cord-291727-4wfhuvww	305	66	from	from	IN
cord-291727-4wfhuvww	305	67	yeast	yeast	NN
cord-291727-4wfhuvww	305	68	to	to	IN
cord-291727-4wfhuvww	305	69	mammals	mammal	NNS
cord-291727-4wfhuvww	305	70	Identification	identification	NN
cord-291727-4wfhuvww	305	71	of	of	IN
cord-291727-4wfhuvww	305	72	a	a	DT
cord-291727-4wfhuvww	305	73	cellular	cellular	JJ
cord-291727-4wfhuvww	305	74	factor	factor	NN
cord-291727-4wfhuvww	305	75	that	that	WDT
cord-291727-4wfhuvww	305	76	modulates	modulate	VBZ
cord-291727-4wfhuvww	306	1	HIV-1	HIV-1	NNP
cord-291727-4wfhuvww	306	2	programmed	program	VBD
cord-291727-4wfhuvww	306	3	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	306	4	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	306	5	Small	small	JJ
cord-291727-4wfhuvww	306	6	peptides	peptide	NNS
cord-291727-4wfhuvww	306	7	switch	switch	VBP
cord-291727-4wfhuvww	306	8	the	the	DT
cord-291727-4wfhuvww	306	9	transcriptional	transcriptional	JJ
cord-291727-4wfhuvww	306	10	activity	activity	NN
cord-291727-4wfhuvww	306	11	of	of	IN
cord-291727-4wfhuvww	306	12	Shavenbaby	Shavenbaby	NNPS
cord-291727-4wfhuvww	306	13	during	during	IN
cord-291727-4wfhuvww	306	14	Drosophila	drosophila	JJ
cord-291727-4wfhuvww	306	15	embryogenesis	embryogenesis	NN
cord-291727-4wfhuvww	306	16	Annexin	Annexin	NNP
cord-291727-4wfhuvww	306	17	A2	A2	NNP
cord-291727-4wfhuvww	306	18	binds	bind	VBZ
cord-291727-4wfhuvww	306	19	RNA	RNA	NNP
cord-291727-4wfhuvww	306	20	and	and	CC
cord-291727-4wfhuvww	306	21	reduces	reduce	VBZ
cord-291727-4wfhuvww	306	22	the	the	DT
cord-291727-4wfhuvww	306	23	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	306	24	efficiency	efficiency	NN
cord-291727-4wfhuvww	306	25	of	of	IN
cord-291727-4wfhuvww	306	26	infectious	infectious	JJ
cord-291727-4wfhuvww	306	27	bronchitis	bronchitis	NN
cord-291727-4wfhuvww	306	28	virus	virus	NN
cord-291727-4wfhuvww	306	29	Ribosome	Ribosome	NNP
cord-291727-4wfhuvww	306	30	can	can	MD
cord-291727-4wfhuvww	306	31	resume	resume	VB
cord-291727-4wfhuvww	306	32	the	the	DT
cord-291727-4wfhuvww	306	33	translation	translation	NN
cord-291727-4wfhuvww	306	34	in	in	IN
cord-291727-4wfhuvww	306	35	both	both	CC
cord-291727-4wfhuvww	306	36	+1	+1	NNS
cord-291727-4wfhuvww	306	37	or	or	CC
cord-291727-4wfhuvww	306	38	−1	−1	NNP
cord-291727-4wfhuvww	306	39	frames	frame	NNS
cord-291727-4wfhuvww	306	40	after	after	IN
cord-291727-4wfhuvww	306	41	encountering	encounter	VBG
cord-291727-4wfhuvww	306	42	an	an	DT
cord-291727-4wfhuvww	306	43	AGA	AGA	NNP
cord-291727-4wfhuvww	306	44	cluster	cluster	NN
cord-291727-4wfhuvww	306	45	in	in	IN
cord-291727-4wfhuvww	306	46	Escherichia	Escherichia	NNP
cord-291727-4wfhuvww	306	47	coli	coli	VBZ
cord-291727-4wfhuvww	306	48	FSscan	FSscan	NNP
cord-291727-4wfhuvww	306	49	:	:	:
cord-291727-4wfhuvww	306	50	a	a	DT
cord-291727-4wfhuvww	306	51	mechanism	mechanism	NN
cord-291727-4wfhuvww	306	52	-	-	HYPH
cord-291727-4wfhuvww	306	53	based	base	VBN
cord-291727-4wfhuvww	306	54	program	program	NN
cord-291727-4wfhuvww	306	55	to	to	TO
cord-291727-4wfhuvww	306	56	identify	identify	VB
cord-291727-4wfhuvww	306	57	+1	+1	XX
cord-291727-4wfhuvww	306	58	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	306	59	frameshift	frameshift	NN
cord-291727-4wfhuvww	306	60	hotspots	hotspot	NNS
cord-291727-4wfhuvww	306	61	Gene	Gene	NNP
cord-291727-4wfhuvww	306	62	expression	expression	NN
cord-291727-4wfhuvww	306	63	from	from	IN
cord-291727-4wfhuvww	306	64	viral	viral	JJ
cord-291727-4wfhuvww	306	65	RNA	RNA	NNP
cord-291727-4wfhuvww	306	66	genomes	genome	NNS
cord-291727-4wfhuvww	306	67	Gentamicin	gentamicin	NN
cord-291727-4wfhuvww	306	68	-	-	HYPH
cord-291727-4wfhuvww	306	69	induced	induce	VBN
cord-291727-4wfhuvww	306	70	readthrough	readthrough	NN
cord-291727-4wfhuvww	306	71	of	of	IN
cord-291727-4wfhuvww	306	72	stop	stop	NN
cord-291727-4wfhuvww	306	73	codons	codon	NNS
cord-291727-4wfhuvww	306	74	in	in	IN
cord-291727-4wfhuvww	306	75	Duchenne	Duchenne	NNP
cord-291727-4wfhuvww	306	76	muscular	muscular	JJ
cord-291727-4wfhuvww	306	77	dystrophy	dystrophy	NN
cord-291727-4wfhuvww	306	78	Aminoglycoside	Aminoglycoside	NNP
cord-291727-4wfhuvww	306	79	suppression	suppression	NN
cord-291727-4wfhuvww	306	80	at	at	IN
cord-291727-4wfhuvww	306	81	UAG	UAG	NNP
cord-291727-4wfhuvww	306	82	,	,	,
cord-291727-4wfhuvww	306	83	UAA	UAA	NNP
cord-291727-4wfhuvww	306	84	and	and	CC
cord-291727-4wfhuvww	306	85	UGA	UGA	NNP
cord-291727-4wfhuvww	306	86	codons	codon	NNS
cord-291727-4wfhuvww	306	87	in	in	IN
cord-291727-4wfhuvww	306	88	Escherichia	Escherichia	NNP
cord-291727-4wfhuvww	306	89	coli	coli	NNS
cord-291727-4wfhuvww	306	90	and	and	CC
cord-291727-4wfhuvww	306	91	human	human	JJ
cord-291727-4wfhuvww	306	92	tissue	tissue	NN
cord-291727-4wfhuvww	306	93	culture	culture	NN
cord-291727-4wfhuvww	306	94	cells	cell	NNS
cord-291727-4wfhuvww	307	1	Extensive	extensive	JJ
cord-291727-4wfhuvww	307	2	frameshift	frameshift	NN
cord-291727-4wfhuvww	307	3	at	at	IN
cord-291727-4wfhuvww	307	4	all	all	DT
cord-291727-4wfhuvww	307	5	AGG	AGG	NNP
cord-291727-4wfhuvww	307	6	and	and	CC
cord-291727-4wfhuvww	307	7	CCC	CCC	NNP
cord-291727-4wfhuvww	307	8	codons	codon	NNS
cord-291727-4wfhuvww	307	9	in	in	IN
cord-291727-4wfhuvww	307	10	the	the	DT
cord-291727-4wfhuvww	307	11	mitochondrial	mitochondrial	JJ
cord-291727-4wfhuvww	307	12	cytochrome	cytochrome	NN
cord-291727-4wfhuvww	307	13	c	c	NN
cord-291727-4wfhuvww	307	14	oxidase	oxidase	NN
cord-291727-4wfhuvww	307	15	subunit	subunit	NN
cord-291727-4wfhuvww	307	16	1	1	CD
cord-291727-4wfhuvww	307	17	gene	gene	NN
cord-291727-4wfhuvww	307	18	of	of	IN
cord-291727-4wfhuvww	307	19	Perkinsus	Perkinsus	NNP
cord-291727-4wfhuvww	307	20	marinus	marinus	NNP
cord-291727-4wfhuvww	307	21	(	(	-LRB-
cord-291727-4wfhuvww	307	22	Alveolata	Alveolata	NNP
cord-291727-4wfhuvww	307	23	;	;	:
cord-291727-4wfhuvww	307	24	Dinoflagellata	Dinoflagellata	NNP
cord-291727-4wfhuvww	307	25	)	)	-RRB-
cord-291727-4wfhuvww	307	26	Observation	observation	NN
cord-291727-4wfhuvww	307	27	of	of	IN
cord-291727-4wfhuvww	307	28	dually	dually	RB
cord-291727-4wfhuvww	307	29	decoded	decode	VBN
cord-291727-4wfhuvww	307	30	regions	region	NNS
cord-291727-4wfhuvww	307	31	of	of	IN
cord-291727-4wfhuvww	307	32	the	the	DT
cord-291727-4wfhuvww	307	33	human	human	JJ
cord-291727-4wfhuvww	307	34	genome	genome	NN
cord-291727-4wfhuvww	307	35	using	use	VBG
cord-291727-4wfhuvww	307	36	ribosome	ribosome	NN
cord-291727-4wfhuvww	307	37	profiling	profiling	NN
cord-291727-4wfhuvww	307	38	data	datum	NNS
cord-291727-4wfhuvww	308	1	FSDB	FSDB	NNP
cord-291727-4wfhuvww	308	2	:	:	:
cord-291727-4wfhuvww	309	1	a	a	DT
cord-291727-4wfhuvww	309	2	frameshift	frameshift	NN
cord-291727-4wfhuvww	309	3	signal	signal	NN
cord-291727-4wfhuvww	309	4	database	database	NN
cord-291727-4wfhuvww	309	5	Antizyme	Antizyme	NNP
cord-291727-4wfhuvww	309	6	,	,	,
cord-291727-4wfhuvww	309	7	a	a	DT
cord-291727-4wfhuvww	309	8	protein	protein	NN
cord-291727-4wfhuvww	309	9	induced	induce	VBN
cord-291727-4wfhuvww	309	10	by	by	IN
cord-291727-4wfhuvww	309	11	polyamines	polyamine	NNS
cord-291727-4wfhuvww	309	12	,	,	,
cord-291727-4wfhuvww	309	13	accelerates	accelerate	VBZ
cord-291727-4wfhuvww	309	14	the	the	DT
cord-291727-4wfhuvww	309	15	degradation	degradation	NN
cord-291727-4wfhuvww	309	16	of	of	IN
cord-291727-4wfhuvww	309	17	ornithine	ornithine	NN
cord-291727-4wfhuvww	309	18	decarboxylase	decarboxylase	NN
cord-291727-4wfhuvww	309	19	in	in	IN
cord-291727-4wfhuvww	309	20	Chinese	chinese	JJ
cord-291727-4wfhuvww	309	21	-	-	HYPH
cord-291727-4wfhuvww	309	22	hamster	hamster	NN
cord-291727-4wfhuvww	309	23	ovary	ovary	NN
cord-291727-4wfhuvww	309	24	-	-	HYPH
cord-291727-4wfhuvww	309	25	cell	cell	NN
cord-291727-4wfhuvww	309	26	extracts	extract	VBZ
cord-291727-4wfhuvww	309	27	A	a	DT
cord-291727-4wfhuvww	309	28	rule	rule	NN
cord-291727-4wfhuvww	309	29	for	for	IN
cord-291727-4wfhuvww	309	30	termination	termination	NN
cord-291727-4wfhuvww	309	31	-	-	HYPH
cord-291727-4wfhuvww	309	32	codon	codon	NN
cord-291727-4wfhuvww	309	33	position	position	NN
cord-291727-4wfhuvww	309	34	within	within	IN
cord-291727-4wfhuvww	309	35	intron	intron	NN
cord-291727-4wfhuvww	309	36	-	-	HYPH
cord-291727-4wfhuvww	309	37	containing	contain	VBG
cord-291727-4wfhuvww	309	38	genes	gene	NNS
cord-291727-4wfhuvww	309	39	:	:	:
cord-291727-4wfhuvww	309	40	when	when	WRB
cord-291727-4wfhuvww	309	41	nonsense	nonsense	NN
cord-291727-4wfhuvww	309	42	affects	affect	VBZ
cord-291727-4wfhuvww	309	43	RNA	RNA	NNP
cord-291727-4wfhuvww	309	44	abundance	abundance	NN
cord-291727-4wfhuvww	310	1	A	a	DT
cord-291727-4wfhuvww	310	2	mechanical	mechanical	JJ
cord-291727-4wfhuvww	310	3	explanation	explanation	NN
cord-291727-4wfhuvww	310	4	of	of	IN
cord-291727-4wfhuvww	310	5	RNA	RNA	NNP
cord-291727-4wfhuvww	310	6	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	310	7	function	function	VB
cord-291727-4wfhuvww	310	8	in	in	IN
cord-291727-4wfhuvww	310	9	programmed	program	VBN
cord-291727-4wfhuvww	310	10	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	310	11	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	310	12	Reprogrammed	reprogrammed	JJ
cord-291727-4wfhuvww	310	13	genetic	genetic	JJ
cord-291727-4wfhuvww	310	14	decoding	decoding	NN
cord-291727-4wfhuvww	310	15	in	in	IN
cord-291727-4wfhuvww	310	16	cellular	cellular	JJ
cord-291727-4wfhuvww	310	17	gene	gene	NN
cord-291727-4wfhuvww	310	18	expression	expression	NN
cord-291727-4wfhuvww	311	1	Polyamines	polyamine	NNS
cord-291727-4wfhuvww	311	2	regulate	regulate	VBP
cord-291727-4wfhuvww	311	3	both	both	DT
cord-291727-4wfhuvww	311	4	transcription	transcription	NN
cord-291727-4wfhuvww	311	5	and	and	CC
cord-291727-4wfhuvww	311	6	translation	translation	NN
cord-291727-4wfhuvww	311	7	of	of	IN
cord-291727-4wfhuvww	311	8	the	the	DT
cord-291727-4wfhuvww	311	9	gene	gene	NN
cord-291727-4wfhuvww	311	10	encoding	encode	VBG
cord-291727-4wfhuvww	311	11	ornithine	ornithine	NN
cord-291727-4wfhuvww	311	12	decarboxylase	decarboxylase	NN
cord-291727-4wfhuvww	311	13	antizyme	antizyme	NNS
cord-291727-4wfhuvww	311	14	in	in	IN
cord-291727-4wfhuvww	311	15	mouse	mouse	NN
cord-291727-4wfhuvww	311	16	Birth	birth	NN
cord-291727-4wfhuvww	311	17	of	of	IN
cord-291727-4wfhuvww	311	18	a	a	DT
cord-291727-4wfhuvww	311	19	unique	unique	JJ
cord-291727-4wfhuvww	311	20	enzyme	enzyme	NN
cord-291727-4wfhuvww	311	21	from	from	IN
cord-291727-4wfhuvww	311	22	an	an	DT
cord-291727-4wfhuvww	311	23	alternative	alternative	JJ
cord-291727-4wfhuvww	311	24	reading	reading	NN
cord-291727-4wfhuvww	311	25	frame	frame	NN
cord-291727-4wfhuvww	311	26	of	of	IN
cord-291727-4wfhuvww	311	27	the	the	DT
cord-291727-4wfhuvww	311	28	preexisted	preexisted	JJ
cord-291727-4wfhuvww	311	29	,	,	,
cord-291727-4wfhuvww	311	30	internally	internally	RB
cord-291727-4wfhuvww	311	31	repetitious	repetitious	JJ
cord-291727-4wfhuvww	311	32	coding	coding	NN
cord-291727-4wfhuvww	311	33	sequence	sequence	NN
cord-291727-4wfhuvww	311	34	Frequent	frequent	JJ
cord-291727-4wfhuvww	311	35	appearance	appearance	NN
cord-291727-4wfhuvww	311	36	of	of	IN
cord-291727-4wfhuvww	311	37	novel	novel	JJ
cord-291727-4wfhuvww	311	38	protein	protein	NN
cord-291727-4wfhuvww	311	39	-	-	HYPH
cord-291727-4wfhuvww	311	40	coding	code	VBG
cord-291727-4wfhuvww	311	41	sequences	sequence	NNS
cord-291727-4wfhuvww	311	42	by	by	IN
cord-291727-4wfhuvww	311	43	frameshift	frameshift	NN
cord-291727-4wfhuvww	311	44	translation	translation	NN
cord-291727-4wfhuvww	312	1	A	a	DT
cord-291727-4wfhuvww	312	2	programmed	program	VBN
cord-291727-4wfhuvww	312	3	−1	−1	NNP
cord-291727-4wfhuvww	312	4	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	312	5	frameshift	frameshift	NN
cord-291727-4wfhuvww	312	6	signal	signal	NN
cord-291727-4wfhuvww	312	7	can	can	MD
cord-291727-4wfhuvww	312	8	function	function	VB
cord-291727-4wfhuvww	312	9	as	as	IN
cord-291727-4wfhuvww	312	10	a	a	DT
cord-291727-4wfhuvww	312	11	cis	cis	NNP
cord-291727-4wfhuvww	312	12	-	-	HYPH
cord-291727-4wfhuvww	312	13	acting	act	VBG
cord-291727-4wfhuvww	312	14	mRNA	mRNA	NNP
cord-291727-4wfhuvww	312	15	destabilizing	destabilize	VBG
cord-291727-4wfhuvww	312	16	element	element	NN
cord-291727-4wfhuvww	312	17	Functional	functional	JJ
cord-291727-4wfhuvww	312	18	divergence	divergence	NN
cord-291727-4wfhuvww	312	19	of	of	IN
cord-291727-4wfhuvww	312	20	proteins	protein	NNS
cord-291727-4wfhuvww	312	21	through	through	IN
cord-291727-4wfhuvww	312	22	frameshift	frameshift	NN
cord-291727-4wfhuvww	312	23	mutations	mutation	NNS
cord-291727-4wfhuvww	312	24	A	a	DT
cord-291727-4wfhuvww	312	25	rapid	rapid	JJ
cord-291727-4wfhuvww	312	26	,	,	,
cord-291727-4wfhuvww	312	27	inexpensive	inexpensive	JJ
cord-291727-4wfhuvww	312	28	yeast	yeast	NN
cord-291727-4wfhuvww	312	29	-	-	HYPH
cord-291727-4wfhuvww	312	30	based	base	VBN
cord-291727-4wfhuvww	312	31	dual	dual	JJ
cord-291727-4wfhuvww	312	32	-	-	HYPH
cord-291727-4wfhuvww	312	33	fluorescence	fluorescence	NN
cord-291727-4wfhuvww	312	34	assay	assay	NN
cord-291727-4wfhuvww	312	35	of	of	IN
cord-291727-4wfhuvww	312	36	programmed-1	programmed-1	NNP
cord-291727-4wfhuvww	312	37	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	312	38	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	312	39	for	for	IN
cord-291727-4wfhuvww	312	40	high	high	JJ
cord-291727-4wfhuvww	312	41	-	-	HYPH
cord-291727-4wfhuvww	312	42	throughput	throughput	NN
cord-291727-4wfhuvww	312	43	screening	screening	NN
cord-291727-4wfhuvww	312	44	Origin	origin	NN
cord-291727-4wfhuvww	312	45	and	and	CC
cord-291727-4wfhuvww	312	46	evolution	evolution	NN
cord-291727-4wfhuvww	312	47	of	of	IN
cord-291727-4wfhuvww	312	48	a	a	DT
cord-291727-4wfhuvww	312	49	new	new	JJ
cord-291727-4wfhuvww	312	50	gene	gene	NN
cord-291727-4wfhuvww	312	51	expressed	express	VBN
cord-291727-4wfhuvww	312	52	in	in	IN
cord-291727-4wfhuvww	312	53	the	the	DT
cord-291727-4wfhuvww	312	54	Drosophila	Drosophila	NNP
cord-291727-4wfhuvww	312	55	sperm	sperm	NN
cord-291727-4wfhuvww	312	56	axoneme	axoneme	NN
cord-291727-4wfhuvww	312	57	Amino	Amino	NNP
cord-291727-4wfhuvww	312	58	acids	acid	NNS
cord-291727-4wfhuvww	312	59	regulate	regulate	VBP
cord-291727-4wfhuvww	312	60	expression	expression	NN
cord-291727-4wfhuvww	312	61	of	of	IN
cord-291727-4wfhuvww	312	62	antizyme-1	antizyme-1	NN
cord-291727-4wfhuvww	312	63	to	to	TO
cord-291727-4wfhuvww	312	64	modulate	modulate	VB
cord-291727-4wfhuvww	312	65	ornithine	ornithine	NN
cord-291727-4wfhuvww	312	66	decarboxylase	decarboxylase	NN
cord-291727-4wfhuvww	312	67	activity	activity	NN
cord-291727-4wfhuvww	312	68	HotKnots	HotKnots	NNPS
cord-291727-4wfhuvww	312	69	:	:	:
cord-291727-4wfhuvww	312	70	heuristic	heuristic	JJ
cord-291727-4wfhuvww	312	71	prediction	prediction	NN
cord-291727-4wfhuvww	312	72	of	of	IN
cord-291727-4wfhuvww	312	73	RNA	RNA	NNP
cord-291727-4wfhuvww	312	74	secondary	secondary	JJ
cord-291727-4wfhuvww	312	75	structures	structure	NNS
cord-291727-4wfhuvww	312	76	including	include	VBG
cord-291727-4wfhuvww	312	77	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	312	78	A	a	DT
cord-291727-4wfhuvww	312	79	dynamic	dynamic	JJ
cord-291727-4wfhuvww	312	80	programming	programming	NN
cord-291727-4wfhuvww	312	81	algorithm	algorithm	NN
cord-291727-4wfhuvww	312	82	for	for	IN
cord-291727-4wfhuvww	312	83	RNA	RNA	NNP
cord-291727-4wfhuvww	312	84	structure	structure	NN
cord-291727-4wfhuvww	312	85	prediction	prediction	NN
cord-291727-4wfhuvww	312	86	including	include	VBG
cord-291727-4wfhuvww	312	87	pseudoknots	pseudoknot	NNS
cord-291727-4wfhuvww	313	1	An	an	DT
cord-291727-4wfhuvww	313	2	overlapping	overlap	VBG
cord-291727-4wfhuvww	313	3	genetic	genetic	JJ
cord-291727-4wfhuvww	313	4	code	code	NN
cord-291727-4wfhuvww	313	5	for	for	IN
cord-291727-4wfhuvww	313	6	frameshifted	frameshifte	VBN
cord-291727-4wfhuvww	313	7	overlapping	overlapping	JJ
cord-291727-4wfhuvww	313	8	genes	gene	NNS
cord-291727-4wfhuvww	313	9	in	in	IN
cord-291727-4wfhuvww	313	10	Drosophila	Drosophila	NNP
cord-291727-4wfhuvww	313	11	mitochondria	mitochondrion	NNS
cord-291727-4wfhuvww	313	12	:	:	:
cord-291727-4wfhuvww	314	1	antisense	antisense	NNP
cord-291727-4wfhuvww	314	2	antitermination	antitermination	NNP
cord-291727-4wfhuvww	314	3	tRNAs	tRNAs	NNP
cord-291727-4wfhuvww	315	1	UAR	UAR	NNP
cord-291727-4wfhuvww	315	2	insert	insert	NN
cord-291727-4wfhuvww	315	3	serine	serine	NN
cord-291727-4wfhuvww	315	4	Computational	computational	JJ
cord-291727-4wfhuvww	315	5	identification	identification	NN
cord-291727-4wfhuvww	315	6	of	of	IN
cord-291727-4wfhuvww	315	7	putative	putative	JJ
cord-291727-4wfhuvww	315	8	programmed	program	VBN
cord-291727-4wfhuvww	315	9	translational	translational	JJ
cord-291727-4wfhuvww	315	10	frameshift	frameshift	NN
cord-291727-4wfhuvww	315	11	sites	site	NNS
cord-291727-4wfhuvww	315	12	Major	major	JJ
cord-291727-4wfhuvww	315	13	histocompatibility	histocompatibility	NN
cord-291727-4wfhuvww	315	14	class	class	NN
cord-291727-4wfhuvww	316	1	I	-PRON-	PRP
cord-291727-4wfhuvww	316	2	molecules	molecule	NNS
cord-291727-4wfhuvww	316	3	can	can	MD
cord-291727-4wfhuvww	316	4	present	present	VB
cord-291727-4wfhuvww	316	5	cryptic	cryptic	JJ
cord-291727-4wfhuvww	316	6	Hungry	Hungry	NNP
cord-291727-4wfhuvww	316	7	codons	codon	NNS
cord-291727-4wfhuvww	316	8	promote	promote	VBP
cord-291727-4wfhuvww	316	9	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	316	10	in	in	IN
cord-291727-4wfhuvww	316	11	human	human	JJ
cord-291727-4wfhuvww	316	12	mitochondrial	mitochondrial	NN
cord-291727-4wfhuvww	316	13	ribosomes	ribosomes	VBP
cord-291727-4wfhuvww	316	14	KnotInFrame	KnotInFrame	NNP
cord-291727-4wfhuvww	316	15	:	:	:
cord-291727-4wfhuvww	316	16	prediction	prediction	NN
cord-291727-4wfhuvww	316	17	of	of	IN
cord-291727-4wfhuvww	316	18	−1	−1	NNP
cord-291727-4wfhuvww	316	19	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	316	20	frameshift	frameshift	NN
cord-291727-4wfhuvww	316	21	events	event	NNS
cord-291727-4wfhuvww	316	22	mRNA	mRNA	NNP
cord-291727-4wfhuvww	316	23	pseudoknot	pseudoknot	NNP
cord-291727-4wfhuvww	316	24	structures	structure	NNS
cord-291727-4wfhuvww	316	25	can	can	MD
cord-291727-4wfhuvww	316	26	act	act	VB
cord-291727-4wfhuvww	316	27	as	as	IN
cord-291727-4wfhuvww	316	28	ribosomal	ribosomal	JJ
cord-291727-4wfhuvww	316	29	roadblocks	roadblock	NNS
cord-291727-4wfhuvww	317	1	OAZ	OAZ	NNP
cord-291727-4wfhuvww	317	2	-	-	HYPH
cord-291727-4wfhuvww	317	3	t	t	NNP
cord-291727-4wfhuvww	317	4	/	/	SYM
cord-291727-4wfhuvww	317	5	OAZ3	OAZ3	NNP
cord-291727-4wfhuvww	317	6	is	be	VBZ
cord-291727-4wfhuvww	317	7	essential	essential	JJ
cord-291727-4wfhuvww	317	8	for	for	IN
cord-291727-4wfhuvww	317	9	rigid	rigid	JJ
cord-291727-4wfhuvww	317	10	connection	connection	NN
cord-291727-4wfhuvww	317	11	of	of	IN
cord-291727-4wfhuvww	317	12	sperm	sperm	NN
cord-291727-4wfhuvww	317	13	tails	tail	NNS
cord-291727-4wfhuvww	317	14	to	to	IN
cord-291727-4wfhuvww	317	15	heads	head	NNS
cord-291727-4wfhuvww	317	16	in	in	IN
cord-291727-4wfhuvww	317	17	mouse	mouse	NN
cord-291727-4wfhuvww	317	18	Ribosomal	Ribosomal	NNP
cord-291727-4wfhuvww	317	19	frameshifting	frameshifte	VBG
cord-291727-4wfhuvww	317	20	on	on	IN
cord-291727-4wfhuvww	317	21	MJD-1	MJD-1	NNP
cord-291727-4wfhuvww	317	22	transcripts	transcript	NNS
cord-291727-4wfhuvww	317	23	with	with	IN
cord-291727-4wfhuvww	317	24	long	long	JJ
cord-291727-4wfhuvww	317	25	CAG	CAG	NNP
cord-291727-4wfhuvww	317	26	tracts	tract	NNS
cord-291727-4wfhuvww	317	27	I	-PRON-	PRP
cord-291727-4wfhuvww	317	28	would	would	MD
cord-291727-4wfhuvww	317	29	like	like	VB
cord-291727-4wfhuvww	317	30	to	to	TO
cord-291727-4wfhuvww	317	31	thank	thank	VB
cord-291727-4wfhuvww	317	32	Joern	Joern	NNP
cord-291727-4wfhuvww	317	33	Dengjel	Dengjel	NNP
cord-291727-4wfhuvww	317	34	and	and	CC
cord-291727-4wfhuvww	317	35	Martin	Martin	NNP
cord-291727-4wfhuvww	317	36	Raff	Raff	NNP
cord-291727-4wfhuvww	317	37	for	for	IN
cord-291727-4wfhuvww	317	38	critically	critically	RB
cord-291727-4wfhuvww	317	39	reading	read	VBG
cord-291727-4wfhuvww	317	40	the	the	DT
cord-291727-4wfhuvww	317	41	manuscript	manuscript	NN
cord-291727-4wfhuvww	317	42	.	.	.
cord-291727-4wfhuvww	318	1	This	this	DT
cord-291727-4wfhuvww	318	2	work	work	NN
cord-291727-4wfhuvww	318	3	was	be	VBD
cord-291727-4wfhuvww	318	4	supported	support	VBN
cord-291727-4wfhuvww	318	5	by	by	IN
cord-291727-4wfhuvww	318	6	the	the	DT
cord-291727-4wfhuvww	318	7	Medical	Medical	NNP
cord-291727-4wfhuvww	318	8	Research	Research	NNP
cord-291727-4wfhuvww	318	9	Council	Council	NNP
cord-291727-4wfhuvww	318	10	.	.	.
cord-291727-4wfhuvww	319	1	The	the	DT
cord-291727-4wfhuvww	319	2	author	author	NN
cord-291727-4wfhuvww	319	3	declares	declare	VBZ
cord-291727-4wfhuvww	319	4	that	that	IN
cord-291727-4wfhuvww	319	5	the	the	DT
cord-291727-4wfhuvww	319	6	research	research	NN
cord-291727-4wfhuvww	319	7	was	be	VBD
cord-291727-4wfhuvww	319	8	conducted	conduct	VBN
cord-291727-4wfhuvww	319	9	in	in	IN
cord-291727-4wfhuvww	319	10	the	the	DT
cord-291727-4wfhuvww	319	11	absence	absence	NN
cord-291727-4wfhuvww	319	12	of	of	IN
cord-291727-4wfhuvww	319	13	any	any	DT
cord-291727-4wfhuvww	319	14	commercial	commercial	JJ
cord-291727-4wfhuvww	319	15	or	or	CC
cord-291727-4wfhuvww	319	16	financial	financial	JJ
cord-291727-4wfhuvww	319	17	relationships	relationship	NNS
cord-291727-4wfhuvww	319	18	that	that	WDT
cord-291727-4wfhuvww	319	19	could	could	MD
cord-291727-4wfhuvww	319	20	be	be	VB
cord-291727-4wfhuvww	319	21	construed	construe	VBN
cord-291727-4wfhuvww	319	22	as	as	IN
cord-291727-4wfhuvww	319	23	a	a	DT
cord-291727-4wfhuvww	319	24	potential	potential	JJ
cord-291727-4wfhuvww	319	25	conflict	conflict	NN
cord-291727-4wfhuvww	319	26	of	of	IN
cord-291727-4wfhuvww	319	27	interest	interest	NN
cord-291727-4wfhuvww	319	28	.	.	.
cord-291727-4wfhuvww	319	29	 	 	_SP