id	sid	tid	token	lemma	pos
cord-269011-230p8rsf	1	1	key	key	JJ
cord-269011-230p8rsf	1	2	:	:	:
cord-269011-230p8rsf	1	3	cord-269011	cord-269011	NNP
cord-269011-230p8rsf	1	4	-	-	HYPH
cord-269011-230p8rsf	1	5	230p8rsf	230p8rsf	CD
cord-269011-230p8rsf	1	6	authors	author	NNS
cord-269011-230p8rsf	1	7	:	:	:
cord-269011-230p8rsf	1	8	de	de	NNP
cord-269011-230p8rsf	1	9	Haan	Haan	NNP
cord-269011-230p8rsf	1	10	,	,	,
cord-269011-230p8rsf	1	11	Cornelis	Cornelis	NNP
cord-269011-230p8rsf	1	12	A.M.	A.M.	NNP
cord-269011-230p8rsf	1	13	;	;	:
cord-269011-230p8rsf	1	14	Rottier	Rottier	NNP
cord-269011-230p8rsf	1	15	,	,	,
cord-269011-230p8rsf	1	16	Peter	Peter	NNP
cord-269011-230p8rsf	1	17	J.M.	J.M.	NNP
cord-269011-230p8rsf	1	18	title	title	NN
cord-269011-230p8rsf	1	19	:	:	:
cord-269011-230p8rsf	2	1	Molecular	molecular	JJ
cord-269011-230p8rsf	2	2	Interactions	Interactions	NNPS
cord-269011-230p8rsf	2	3	in	in	IN
cord-269011-230p8rsf	2	4	the	the	DT
cord-269011-230p8rsf	2	5	Assembly	Assembly	NNP
cord-269011-230p8rsf	2	6	of	of	IN
cord-269011-230p8rsf	2	7	Coronaviruses	Coronaviruses	NNP
cord-269011-230p8rsf	2	8	date	date	NN
cord-269011-230p8rsf	2	9	:	:	:
cord-269011-230p8rsf	2	10	2005	2005	CD
cord-269011-230p8rsf	2	11	-	-	HYPH
cord-269011-230p8rsf	2	12	08	08	CD
cord-269011-230p8rsf	2	13	-	-	HYPH
cord-269011-230p8rsf	2	14	31	31	CD
cord-269011-230p8rsf	2	15	journal	journal	NN
cord-269011-230p8rsf	2	16	:	:	:
cord-269011-230p8rsf	3	1	Adv	Adv	NNP
cord-269011-230p8rsf	3	2	Virus	virus	NN
cord-269011-230p8rsf	3	3	Res	res	NN
cord-269011-230p8rsf	3	4	DOI	doi	NN
cord-269011-230p8rsf	4	1	:	:	:
cord-269011-230p8rsf	4	2	10.1016	10.1016	CD
cord-269011-230p8rsf	4	3	/	/	SYM
cord-269011-230p8rsf	4	4	s0065	s0065	NNP
cord-269011-230p8rsf	4	5	-	-	HYPH
cord-269011-230p8rsf	4	6	3527(05)64006	3527(05)64006	NNP
cord-269011-230p8rsf	4	7	-	-	HYPH
cord-269011-230p8rsf	4	8	7	7	CD
cord-269011-230p8rsf	4	9	sha	sha	NNP
cord-269011-230p8rsf	4	10	:	:	:
cord-269011-230p8rsf	5	1	edc9be58ec035cfcc86c647ebc021d59214d4fd1	edc9be58ec035cfcc86c647ebc021d59214d4fd1	NNP
cord-269011-230p8rsf	5	2	doc_id	doc_id	CD
cord-269011-230p8rsf	5	3	:	:	:
cord-269011-230p8rsf	5	4	269011	269011	CD
cord-269011-230p8rsf	5	5	cord_uid	cord_uid	NNS
cord-269011-230p8rsf	5	6	:	:	:
cord-269011-230p8rsf	5	7	230p8rsf	230p8rsf	CD
cord-269011-230p8rsf	6	1	This	this	DT
cord-269011-230p8rsf	6	2	chapter	chapter	NN
cord-269011-230p8rsf	6	3	describes	describe	VBZ
cord-269011-230p8rsf	6	4	the	the	DT
cord-269011-230p8rsf	6	5	interactions	interaction	NNS
cord-269011-230p8rsf	6	6	between	between	IN
cord-269011-230p8rsf	6	7	the	the	DT
cord-269011-230p8rsf	6	8	different	different	JJ
cord-269011-230p8rsf	6	9	structural	structural	JJ
cord-269011-230p8rsf	6	10	components	component	NNS
cord-269011-230p8rsf	6	11	of	of	IN
cord-269011-230p8rsf	6	12	the	the	DT
cord-269011-230p8rsf	6	13	viruses	virus	NNS
cord-269011-230p8rsf	6	14	and	and	CC
cord-269011-230p8rsf	6	15	discusses	discuss	VBZ
cord-269011-230p8rsf	6	16	their	-PRON-	PRP$
cord-269011-230p8rsf	6	17	relevance	relevance	NN
cord-269011-230p8rsf	6	18	for	for	IN
cord-269011-230p8rsf	6	19	the	the	DT
cord-269011-230p8rsf	6	20	process	process	NN
cord-269011-230p8rsf	6	21	of	of	IN
cord-269011-230p8rsf	6	22	virion	virion	NN
cord-269011-230p8rsf	6	23	formation	formation	NN
cord-269011-230p8rsf	6	24	.	.	.
cord-269011-230p8rsf	7	1	Two	two	CD
cord-269011-230p8rsf	7	2	key	key	JJ
cord-269011-230p8rsf	7	3	factors	factor	NNS
cord-269011-230p8rsf	7	4	determine	determine	VBP
cord-269011-230p8rsf	7	5	the	the	DT
cord-269011-230p8rsf	7	6	efficiency	efficiency	NN
cord-269011-230p8rsf	7	7	of	of	IN
cord-269011-230p8rsf	7	8	the	the	DT
cord-269011-230p8rsf	7	9	assembly	assembly	NN
cord-269011-230p8rsf	7	10	process	process	NN
cord-269011-230p8rsf	7	11	:	:	:
cord-269011-230p8rsf	7	12	intracellular	intracellular	JJ
cord-269011-230p8rsf	7	13	transport	transport	NN
cord-269011-230p8rsf	7	14	and	and	CC
cord-269011-230p8rsf	7	15	molecular	molecular	JJ
cord-269011-230p8rsf	7	16	interactions	interaction	NNS
cord-269011-230p8rsf	7	17	.	.	.
cord-269011-230p8rsf	8	1	Many	many	JJ
cord-269011-230p8rsf	8	2	viruses	virus	NNS
cord-269011-230p8rsf	8	3	have	have	VBP
cord-269011-230p8rsf	8	4	evolved	evolve	VBN
cord-269011-230p8rsf	8	5	elaborate	elaborate	JJ
cord-269011-230p8rsf	8	6	strategies	strategy	NNS
cord-269011-230p8rsf	8	7	to	to	TO
cord-269011-230p8rsf	8	8	ensure	ensure	VB
cord-269011-230p8rsf	8	9	the	the	DT
cord-269011-230p8rsf	8	10	swift	swift	JJ
cord-269011-230p8rsf	8	11	and	and	CC
cord-269011-230p8rsf	8	12	accurate	accurate	JJ
cord-269011-230p8rsf	8	13	delivery	delivery	NN
cord-269011-230p8rsf	8	14	of	of	IN
cord-269011-230p8rsf	8	15	the	the	DT
cord-269011-230p8rsf	8	16	virion	virion	NN
cord-269011-230p8rsf	8	17	components	component	NNS
cord-269011-230p8rsf	8	18	to	to	IN
cord-269011-230p8rsf	8	19	the	the	DT
cord-269011-230p8rsf	8	20	cellular	cellular	JJ
cord-269011-230p8rsf	8	21	compartment(s	compartment(s	NNP
cord-269011-230p8rsf	8	22	)	)	-RRB-
cord-269011-230p8rsf	8	23	where	where	WRB
cord-269011-230p8rsf	8	24	they	-PRON-	PRP
cord-269011-230p8rsf	8	25	must	must	MD
cord-269011-230p8rsf	8	26	meet	meet	VB
cord-269011-230p8rsf	8	27	and	and	CC
cord-269011-230p8rsf	8	28	form	form	VB
cord-269011-230p8rsf	8	29	(	(	-LRB-
cord-269011-230p8rsf	8	30	sub	sub	NN
cord-269011-230p8rsf	8	31	)	)	-RRB-
cord-269011-230p8rsf	8	32	structures	structure	NNS
cord-269011-230p8rsf	8	33	.	.	.
cord-269011-230p8rsf	9	1	Assembly	assembly	NN
cord-269011-230p8rsf	9	2	of	of	IN
cord-269011-230p8rsf	9	3	viruses	virus	NNS
cord-269011-230p8rsf	9	4	starts	start	VBZ
cord-269011-230p8rsf	9	5	in	in	IN
cord-269011-230p8rsf	9	6	the	the	DT
cord-269011-230p8rsf	9	7	nucleus	nucleus	NN
cord-269011-230p8rsf	9	8	by	by	IN
cord-269011-230p8rsf	9	9	the	the	DT
cord-269011-230p8rsf	9	10	encapsidation	encapsidation	NN
cord-269011-230p8rsf	9	11	of	of	IN
cord-269011-230p8rsf	9	12	viral	viral	JJ
cord-269011-230p8rsf	9	13	DNA	dna	NN
cord-269011-230p8rsf	9	14	,	,	,
cord-269011-230p8rsf	9	15	using	use	VBG
cord-269011-230p8rsf	9	16	cytoplasmically	cytoplasmically	RB
cord-269011-230p8rsf	9	17	synthesized	synthesize	VBN
cord-269011-230p8rsf	9	18	capsid	capsid	NN
cord-269011-230p8rsf	9	19	proteins	protein	NNS
cord-269011-230p8rsf	9	20	;	;	:
cord-269011-230p8rsf	9	21	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	9	22	then	then	RB
cord-269011-230p8rsf	9	23	migrate	migrate	VBP
cord-269011-230p8rsf	9	24	to	to	IN
cord-269011-230p8rsf	9	25	the	the	DT
cord-269011-230p8rsf	9	26	cytosol	cytosol	NN
cord-269011-230p8rsf	9	27	,	,	,
cord-269011-230p8rsf	9	28	by	by	IN
cord-269011-230p8rsf	9	29	budding	bud	VBG
cord-269011-230p8rsf	9	30	at	at	IN
cord-269011-230p8rsf	9	31	the	the	DT
cord-269011-230p8rsf	9	32	inner	inner	JJ
cord-269011-230p8rsf	9	33	nuclear	nuclear	JJ
cord-269011-230p8rsf	9	34	membrane	membrane	NN
cord-269011-230p8rsf	9	35	followed	follow	VBN
cord-269011-230p8rsf	9	36	by	by	IN
cord-269011-230p8rsf	9	37	deenvelopment	deenvelopment	NNP
cord-269011-230p8rsf	9	38	,	,	,
cord-269011-230p8rsf	9	39	to	to	TO
cord-269011-230p8rsf	9	40	pick	pick	VB
cord-269011-230p8rsf	9	41	up	up	RP
cord-269011-230p8rsf	9	42	the	the	DT
cord-269011-230p8rsf	9	43	tegument	tegument	NN
cord-269011-230p8rsf	9	44	proteins	protein	NNS
cord-269011-230p8rsf	9	45	.	.	.
cord-269011-230p8rsf	10	1	Viruses	virus	NNS
cord-269011-230p8rsf	10	2	are	be	VBP
cord-269011-230p8rsf	10	3	multimolecular	multimolecular	JJ
cord-269011-230p8rsf	10	4	assemblies	assembly	NNS
cord-269011-230p8rsf	10	5	that	that	WDT
cord-269011-230p8rsf	10	6	range	range	VBP
cord-269011-230p8rsf	10	7	from	from	IN
cord-269011-230p8rsf	10	8	small	small	JJ
cord-269011-230p8rsf	10	9	,	,	,
cord-269011-230p8rsf	10	10	regular	regular	JJ
cord-269011-230p8rsf	10	11	,	,	,
cord-269011-230p8rsf	10	12	and	and	CC
cord-269011-230p8rsf	10	13	simple	simple	JJ
cord-269011-230p8rsf	10	14	to	to	IN
cord-269011-230p8rsf	10	15	large	large	JJ
cord-269011-230p8rsf	10	16	,	,	,
cord-269011-230p8rsf	10	17	pleiomorphic	pleiomorphic	JJ
cord-269011-230p8rsf	10	18	,	,	,
cord-269011-230p8rsf	10	19	and	and	CC
cord-269011-230p8rsf	10	20	complex	complex	JJ
cord-269011-230p8rsf	10	21	.	.	.
cord-269011-230p8rsf	11	1	They	-PRON-	PRP
cord-269011-230p8rsf	11	2	consist	consist	VBP
cord-269011-230p8rsf	11	3	of	of	IN
cord-269011-230p8rsf	11	4	virus	virus	NN
cord-269011-230p8rsf	11	5	-	-	HYPH
cord-269011-230p8rsf	11	6	specified	specify	VBN
cord-269011-230p8rsf	11	7	proteins	protein	NNS
cord-269011-230p8rsf	11	8	and	and	CC
cord-269011-230p8rsf	11	9	nucleic	nucleic	JJ
cord-269011-230p8rsf	11	10	acids	acid	NNS
cord-269011-230p8rsf	11	11	and	and	CC
cord-269011-230p8rsf	11	12	,	,	,
cord-269011-230p8rsf	11	13	in	in	IN
cord-269011-230p8rsf	11	14	the	the	DT
cord-269011-230p8rsf	11	15	case	case	NN
cord-269011-230p8rsf	11	16	of	of	IN
cord-269011-230p8rsf	11	17	enveloped	envelop	VBN
cord-269011-230p8rsf	11	18	viruses	virus	NNS
cord-269011-230p8rsf	11	19	,	,	,
cord-269011-230p8rsf	11	20	of	of	IN
cord-269011-230p8rsf	11	21	host	host	NN
cord-269011-230p8rsf	11	22	-	-	HYPH
cord-269011-230p8rsf	11	23	derived	derive	VBN
cord-269011-230p8rsf	11	24	lipids	lipid	NNS
cord-269011-230p8rsf	11	25	.	.	.
cord-269011-230p8rsf	12	1	In	in	IN
cord-269011-230p8rsf	12	2	infected	infected	JJ
cord-269011-230p8rsf	12	3	cells	cell	NNS
cord-269011-230p8rsf	12	4	the	the	DT
cord-269011-230p8rsf	12	5	assembly	assembly	NN
cord-269011-230p8rsf	12	6	of	of	IN
cord-269011-230p8rsf	12	7	these	these	DT
cord-269011-230p8rsf	12	8	different	different	JJ
cord-269011-230p8rsf	12	9	components	component	NNS
cord-269011-230p8rsf	12	10	into	into	IN
cord-269011-230p8rsf	12	11	virions	virion	NNS
cord-269011-230p8rsf	12	12	occurs	occur	VBZ
cord-269011-230p8rsf	12	13	with	with	IN
cord-269011-230p8rsf	12	14	high	high	JJ
cord-269011-230p8rsf	12	15	precision	precision	NN
cord-269011-230p8rsf	12	16	amidst	amidst	IN
cord-269011-230p8rsf	12	17	a	a	DT
cord-269011-230p8rsf	12	18	huge	huge	JJ
cord-269011-230p8rsf	12	19	background	background	NN
cord-269011-230p8rsf	12	20	of	of	IN
cord-269011-230p8rsf	12	21	tens	ten	NNS
cord-269011-230p8rsf	12	22	of	of	IN
cord-269011-230p8rsf	12	23	thousands	thousand	NNS
cord-269011-230p8rsf	12	24	of	of	IN
cord-269011-230p8rsf	12	25	host	host	NN
cord-269011-230p8rsf	12	26	compounds	compound	NNS
cord-269011-230p8rsf	12	27	.	.	.
cord-269011-230p8rsf	13	1	Two	two	CD
cord-269011-230p8rsf	13	2	key	key	JJ
cord-269011-230p8rsf	13	3	factors	factor	NNS
cord-269011-230p8rsf	13	4	determine	determine	VBP
cord-269011-230p8rsf	13	5	the	the	DT
cord-269011-230p8rsf	13	6	efficiency	efficiency	NN
cord-269011-230p8rsf	13	7	of	of	IN
cord-269011-230p8rsf	13	8	the	the	DT
cord-269011-230p8rsf	13	9	assembly	assembly	NN
cord-269011-230p8rsf	13	10	process	process	NN
cord-269011-230p8rsf	13	11	:	:	:
cord-269011-230p8rsf	13	12	intracellular	intracellular	JJ
cord-269011-230p8rsf	13	13	transport	transport	NN
cord-269011-230p8rsf	13	14	and	and	CC
cord-269011-230p8rsf	13	15	molecular	molecular	JJ
cord-269011-230p8rsf	13	16	interactions	interaction	NNS
cord-269011-230p8rsf	13	17	.	.	.
cord-269011-230p8rsf	14	1	Directional	directional	JJ
cord-269011-230p8rsf	14	2	transport	transport	NN
cord-269011-230p8rsf	14	3	ensures	ensure	VBZ
cord-269011-230p8rsf	14	4	the	the	DT
cord-269011-230p8rsf	14	5	swift	swift	JJ
cord-269011-230p8rsf	14	6	and	and	CC
cord-269011-230p8rsf	14	7	accurate	accurate	JJ
cord-269011-230p8rsf	14	8	delivery	delivery	NN
cord-269011-230p8rsf	14	9	of	of	IN
cord-269011-230p8rsf	14	10	the	the	DT
cord-269011-230p8rsf	14	11	virion	virion	NN
cord-269011-230p8rsf	14	12	components	component	NNS
cord-269011-230p8rsf	14	13	to	to	IN
cord-269011-230p8rsf	14	14	the	the	DT
cord-269011-230p8rsf	14	15	cellular	cellular	JJ
cord-269011-230p8rsf	14	16	compartment(s	compartment(s	NNP
cord-269011-230p8rsf	14	17	)	)	-RRB-
cord-269011-230p8rsf	14	18	where	where	WRB
cord-269011-230p8rsf	14	19	they	-PRON-	PRP
cord-269011-230p8rsf	14	20	must	must	MD
cord-269011-230p8rsf	14	21	meet	meet	VB
cord-269011-230p8rsf	14	22	and	and	CC
cord-269011-230p8rsf	14	23	form	form	VB
cord-269011-230p8rsf	14	24	(	(	-LRB-
cord-269011-230p8rsf	14	25	sub)structures	sub)structure	NNS
cord-269011-230p8rsf	14	26	.	.	.
cord-269011-230p8rsf	15	1	Some	some	DT
cord-269011-230p8rsf	15	2	viruses	virus	NNS
cord-269011-230p8rsf	15	3	achieve	achieve	VBP
cord-269011-230p8rsf	15	4	this	this	DT
cord-269011-230p8rsf	15	5	goal	goal	NN
cord-269011-230p8rsf	15	6	relatively	relatively	RB
cord-269011-230p8rsf	15	7	simply	simply	RB
cord-269011-230p8rsf	15	8	when	when	WRB
cord-269011-230p8rsf	15	9	genome	genome	NN
cord-269011-230p8rsf	15	10	production	production	NN
cord-269011-230p8rsf	15	11	occurs	occur	VBZ
cord-269011-230p8rsf	15	12	in	in	IN
cord-269011-230p8rsf	15	13	close	close	JJ
cord-269011-230p8rsf	15	14	proximity	proximity	NN
cord-269011-230p8rsf	15	15	to	to	IN
cord-269011-230p8rsf	15	16	the	the	DT
cord-269011-230p8rsf	15	17	virion	virion	NN
cord-269011-230p8rsf	15	18	assembly	assembly	NN
cord-269011-230p8rsf	15	19	site	site	NN
cord-269011-230p8rsf	15	20	(	(	-LRB-
cord-269011-230p8rsf	15	21	e.g.	e.g.	RB
cord-269011-230p8rsf	15	22	,	,	,
cord-269011-230p8rsf	15	23	picornaviruses	picornaviruses	NNP
cord-269011-230p8rsf	15	24	)	)	-RRB-
cord-269011-230p8rsf	15	25	.	.	.
cord-269011-230p8rsf	16	1	Many	many	JJ
cord-269011-230p8rsf	16	2	viruses	virus	NNS
cord-269011-230p8rsf	16	3	,	,	,
cord-269011-230p8rsf	16	4	however	however	RB
cord-269011-230p8rsf	16	5	,	,	,
cord-269011-230p8rsf	16	6	have	have	VBP
cord-269011-230p8rsf	16	7	evolved	evolve	VBN
cord-269011-230p8rsf	16	8	more	more	RBR
cord-269011-230p8rsf	16	9	elaborate	elaborate	JJ
cord-269011-230p8rsf	16	10	strategies	strategy	NNS
cord-269011-230p8rsf	16	11	.	.	.
cord-269011-230p8rsf	17	1	This	this	DT
cord-269011-230p8rsf	17	2	is	be	VBZ
cord-269011-230p8rsf	17	3	illustrated	illustrate	VBN
cord-269011-230p8rsf	17	4	,	,	,
cord-269011-230p8rsf	17	5	for	for	IN
cord-269011-230p8rsf	17	6	instance	instance	NN
cord-269011-230p8rsf	17	7	,	,	,
cord-269011-230p8rsf	17	8	by	by	IN
cord-269011-230p8rsf	17	9	the	the	DT
cord-269011-230p8rsf	17	10	a	a	NNP
cord-269011-230p8rsf	17	11	-	-	HYPH
cord-269011-230p8rsf	17	12	herpesviruses	herpesviruse	NNS
cord-269011-230p8rsf	17	13	.	.	.
cord-269011-230p8rsf	18	1	Assembly	assembly	NN
cord-269011-230p8rsf	18	2	of	of	IN
cord-269011-230p8rsf	18	3	these	these	DT
cord-269011-230p8rsf	18	4	viruses	virus	NNS
cord-269011-230p8rsf	18	5	starts	start	VBZ
cord-269011-230p8rsf	18	6	in	in	IN
cord-269011-230p8rsf	18	7	the	the	DT
cord-269011-230p8rsf	18	8	nucleus	nucleus	NN
cord-269011-230p8rsf	18	9	by	by	IN
cord-269011-230p8rsf	18	10	the	the	DT
cord-269011-230p8rsf	18	11	encapsidation	encapsidation	NN
cord-269011-230p8rsf	18	12	of	of	IN
cord-269011-230p8rsf	18	13	viral	viral	JJ
cord-269011-230p8rsf	18	14	DNA	dna	NN
cord-269011-230p8rsf	18	15	,	,	,
cord-269011-230p8rsf	18	16	using	use	VBG
cord-269011-230p8rsf	18	17	cytoplasmically	cytoplasmically	RB
cord-269011-230p8rsf	18	18	synthesized	synthesize	VBN
cord-269011-230p8rsf	18	19	capsid	capsid	NN
cord-269011-230p8rsf	18	20	proteins	protein	NNS
cord-269011-230p8rsf	18	21	;	;	:
cord-269011-230p8rsf	18	22	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	18	23	then	then	RB
cord-269011-230p8rsf	18	24	migrate	migrate	VBP
cord-269011-230p8rsf	18	25	to	to	IN
cord-269011-230p8rsf	18	26	the	the	DT
cord-269011-230p8rsf	18	27	cytosol	cytosol	NN
cord-269011-230p8rsf	18	28	,	,	,
cord-269011-230p8rsf	18	29	by	by	IN
cord-269011-230p8rsf	18	30	budding	bud	VBG
cord-269011-230p8rsf	18	31	at	at	IN
cord-269011-230p8rsf	18	32	the	the	DT
cord-269011-230p8rsf	18	33	inner	inner	JJ
cord-269011-230p8rsf	18	34	nuclear	nuclear	JJ
cord-269011-230p8rsf	18	35	membrane	membrane	NN
cord-269011-230p8rsf	18	36	followed	follow	VBN
cord-269011-230p8rsf	18	37	by	by	IN
cord-269011-230p8rsf	18	38	deenvelopment	deenvelopment	NNP
cord-269011-230p8rsf	18	39	,	,	,
cord-269011-230p8rsf	18	40	to	to	TO
cord-269011-230p8rsf	18	41	pick	pick	VB
cord-269011-230p8rsf	18	42	up	up	RP
cord-269011-230p8rsf	18	43	the	the	DT
cord-269011-230p8rsf	18	44	tegument	tegument	NN
cord-269011-230p8rsf	18	45	proteins	protein	NNS
cord-269011-230p8rsf	18	46	.	.	.
cord-269011-230p8rsf	19	1	Subsequently	subsequently	RB
cord-269011-230p8rsf	19	2	,	,	,
cord-269011-230p8rsf	19	3	the	the	DT
cord-269011-230p8rsf	19	4	tegumented	tegumente	VBN
cord-269011-230p8rsf	19	5	capsids	capsid	NNS
cord-269011-230p8rsf	19	6	obtain	obtain	VBP
cord-269011-230p8rsf	19	7	their	-PRON-	PRP$
cord-269011-230p8rsf	19	8	final	final	JJ
cord-269011-230p8rsf	19	9	envelope	envelope	NN
cord-269011-230p8rsf	19	10	by	by	IN
cord-269011-230p8rsf	19	11	budding	bud	VBG
cord-269011-230p8rsf	19	12	into	into	IN
cord-269011-230p8rsf	19	13	vesicles	vesicle	NNS
cord-269011-230p8rsf	19	14	of	of	IN
cord-269011-230p8rsf	19	15	the	the	DT
cord-269011-230p8rsf	19	16	trans	trans	NNP
cord-269011-230p8rsf	19	17	-	-	NNP
cord-269011-230p8rsf	19	18	Golgi	Golgi	NNP
cord-269011-230p8rsf	19	19	network	network	NN
cord-269011-230p8rsf	19	20	(	(	-LRB-
cord-269011-230p8rsf	19	21	TGN	TGN	NNP
cord-269011-230p8rsf	19	22	)	)	-RRB-
cord-269011-230p8rsf	19	23	,	,	,
cord-269011-230p8rsf	19	24	where	where	WRB
cord-269011-230p8rsf	19	25	the	the	DT
cord-269011-230p8rsf	19	26	viral	viral	JJ
cord-269011-230p8rsf	19	27	envelope	envelope	NN
cord-269011-230p8rsf	19	28	proteins	protein	NNS
cord-269011-230p8rsf	19	29	have	have	VBP
cord-269011-230p8rsf	19	30	congregated	congregate	VBN
cord-269011-230p8rsf	19	31	after	after	IN
cord-269011-230p8rsf	19	32	their	-PRON-	PRP$
cord-269011-230p8rsf	19	33	synthesis	synthesis	NN
cord-269011-230p8rsf	19	34	in	in	IN
cord-269011-230p8rsf	19	35	the	the	DT
cord-269011-230p8rsf	19	36	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	19	37	reticulum	reticulum	NN
cord-269011-230p8rsf	19	38	;	;	:
cord-269011-230p8rsf	19	39	the	the	DT
cord-269011-230p8rsf	19	40	assembled	assemble	VBN
cord-269011-230p8rsf	19	41	viral	viral	JJ
cord-269011-230p8rsf	19	42	particles	particle	NNS
cord-269011-230p8rsf	19	43	are	be	VBP
cord-269011-230p8rsf	19	44	finally	finally	RB
cord-269011-230p8rsf	19	45	released	release	VBN
cord-269011-230p8rsf	19	46	by	by	IN
cord-269011-230p8rsf	19	47	fusion	fusion	NN
cord-269011-230p8rsf	19	48	of	of	IN
cord-269011-230p8rsf	19	49	the	the	DT
cord-269011-230p8rsf	19	50	virion	virion	NN
cord-269011-230p8rsf	19	51	-	-	HYPH
cord-269011-230p8rsf	19	52	containing	contain	VBG
cord-269011-230p8rsf	19	53	vesicles	vesicle	NNS
cord-269011-230p8rsf	19	54	with	with	IN
cord-269011-230p8rsf	19	55	the	the	DT
cord-269011-230p8rsf	19	56	plasma	plasma	NN
cord-269011-230p8rsf	19	57	membrane	membrane	NN
cord-269011-230p8rsf	19	58	.	.	.
cord-269011-230p8rsf	20	1	To	to	TO
cord-269011-230p8rsf	20	2	achieve	achieve	VB
cord-269011-230p8rsf	20	3	their	-PRON-	PRP$
cord-269011-230p8rsf	20	4	transport	transport	NN
cord-269011-230p8rsf	20	5	goals	goal	NNS
cord-269011-230p8rsf	20	6	viruses	virus	NNS
cord-269011-230p8rsf	20	7	provide	provide	VBP
cord-269011-230p8rsf	20	8	their	-PRON-	PRP$
cord-269011-230p8rsf	20	9	components	component	NNS
cord-269011-230p8rsf	20	10	with	with	IN
cord-269011-230p8rsf	20	11	address	address	NN
cord-269011-230p8rsf	20	12	labels	label	NNS
cord-269011-230p8rsf	20	13	that	that	WDT
cord-269011-230p8rsf	20	14	can	can	MD
cord-269011-230p8rsf	20	15	be	be	VB
cord-269011-230p8rsf	20	16	read	read	VBN
cord-269011-230p8rsf	20	17	by	by	IN
cord-269011-230p8rsf	20	18	the	the	DT
cord-269011-230p8rsf	20	19	transport	transport	NN
cord-269011-230p8rsf	20	20	machinery	machinery	NN
cord-269011-230p8rsf	20	21	of	of	IN
cord-269011-230p8rsf	20	22	the	the	DT
cord-269011-230p8rsf	20	23	cell	cell	NN
cord-269011-230p8rsf	20	24	.	.	.
cord-269011-230p8rsf	21	1	Once	once	RB
cord-269011-230p8rsf	21	2	brought	bring	VBN
cord-269011-230p8rsf	21	3	together	together	RB
cord-269011-230p8rsf	21	4	,	,	,
cord-269011-230p8rsf	21	5	formation	formation	NN
cord-269011-230p8rsf	21	6	of	of	IN
cord-269011-230p8rsf	21	7	the	the	DT
cord-269011-230p8rsf	21	8	viral	viral	JJ
cord-269011-230p8rsf	21	9	(	(	-LRB-
cord-269011-230p8rsf	21	10	sub)structures	sub)structure	NNS
cord-269011-230p8rsf	21	11	is	be	VBZ
cord-269011-230p8rsf	21	12	governed	govern	VBN
cord-269011-230p8rsf	21	13	and	and	CC
cord-269011-230p8rsf	21	14	driven	drive	VBN
cord-269011-230p8rsf	21	15	by	by	IN
cord-269011-230p8rsf	21	16	their	-PRON-	PRP$
cord-269011-230p8rsf	21	17	interactions	interaction	NNS
cord-269011-230p8rsf	21	18	.	.	.
cord-269011-230p8rsf	22	1	Whereas	whereas	IN
cord-269011-230p8rsf	22	2	the	the	DT
cord-269011-230p8rsf	22	3	assembly	assembly	NN
cord-269011-230p8rsf	22	4	of	of	IN
cord-269011-230p8rsf	22	5	nonenveloped	nonenveloped	JJ
cord-269011-230p8rsf	22	6	viruses	virus	NNS
cord-269011-230p8rsf	22	7	is	be	VBZ
cord-269011-230p8rsf	22	8	generally	generally	RB
cord-269011-230p8rsf	22	9	restricted	restrict	VBN
cord-269011-230p8rsf	22	10	to	to	IN
cord-269011-230p8rsf	22	11	the	the	DT
cord-269011-230p8rsf	22	12	cell	cell	NN
cord-269011-230p8rsf	22	13	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	22	14	,	,	,
cord-269011-230p8rsf	22	15	although	although	IN
cord-269011-230p8rsf	22	16	often	often	RB
cord-269011-230p8rsf	22	17	in	in	IN
cord-269011-230p8rsf	22	18	association	association	NN
cord-269011-230p8rsf	22	19	with	with	IN
cord-269011-230p8rsf	22	20	membranes	membrane	NNS
cord-269011-230p8rsf	22	21	,	,	,
cord-269011-230p8rsf	22	22	that	that	DT
cord-269011-230p8rsf	22	23	of	of	IN
cord-269011-230p8rsf	22	24	enveloped	envelop	VBN
cord-269011-230p8rsf	22	25	viruses	virus	NNS
cord-269011-230p8rsf	22	26	involves	involve	VBZ
cord-269011-230p8rsf	22	27	multiple	multiple	JJ
cord-269011-230p8rsf	22	28	cellular	cellular	JJ
cord-269011-230p8rsf	22	29	compartments	compartment	NNS
cord-269011-230p8rsf	22	30	,	,	,
cord-269011-230p8rsf	22	31	as	as	IN
cord-269011-230p8rsf	22	32	exemplified	exemplify	VBN
cord-269011-230p8rsf	22	33	already	already	RB
cord-269011-230p8rsf	22	34	for	for	IN
cord-269011-230p8rsf	22	35	herpesviruses	herpesviruses	NNP
cord-269011-230p8rsf	22	36	.	.	.
cord-269011-230p8rsf	23	1	This	this	DT
cord-269011-230p8rsf	23	2	review	review	NN
cord-269011-230p8rsf	23	3	deals	deal	NNS
cord-269011-230p8rsf	23	4	with	with	IN
cord-269011-230p8rsf	23	5	the	the	DT
cord-269011-230p8rsf	23	6	assembly	assembly	NNP
cord-269011-230p8rsf	23	7	of	of	IN
cord-269011-230p8rsf	23	8	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	23	9	.	.	.
cord-269011-230p8rsf	24	1	We	-PRON-	PRP
cord-269011-230p8rsf	24	2	first	first	RB
cord-269011-230p8rsf	24	3	describe	describe	VBP
cord-269011-230p8rsf	24	4	what	what	WP
cord-269011-230p8rsf	24	5	is	be	VBZ
cord-269011-230p8rsf	24	6	known	know	VBN
cord-269011-230p8rsf	24	7	about	about	IN
cord-269011-230p8rsf	24	8	the	the	DT
cord-269011-230p8rsf	24	9	structure	structure	NN
cord-269011-230p8rsf	24	10	of	of	IN
cord-269011-230p8rsf	24	11	the	the	DT
cord-269011-230p8rsf	24	12	coronavirion	coronavirion	NN
cord-269011-230p8rsf	24	13	and	and	CC
cord-269011-230p8rsf	24	14	about	about	IN
cord-269011-230p8rsf	24	15	the	the	DT
cord-269011-230p8rsf	24	16	relevant	relevant	JJ
cord-269011-230p8rsf	24	17	properties	property	NNS
cord-269011-230p8rsf	24	18	of	of	IN
cord-269011-230p8rsf	24	19	the	the	DT
cord-269011-230p8rsf	24	20	structural	structural	JJ
cord-269011-230p8rsf	24	21	components	component	NNS
cord-269011-230p8rsf	24	22	.	.	.
cord-269011-230p8rsf	25	1	We	-PRON-	PRP
cord-269011-230p8rsf	25	2	summarize	summarize	VBP
cord-269011-230p8rsf	25	3	the	the	DT
cord-269011-230p8rsf	25	4	limited	limited	JJ
cord-269011-230p8rsf	25	5	ultrastructural	ultrastructural	JJ
cord-269011-230p8rsf	25	6	information	information	NN
cord-269011-230p8rsf	25	7	about	about	IN
cord-269011-230p8rsf	25	8	coronavirus	coronavirus	NN
cord-269011-230p8rsf	25	9	assembly	assembly	NN
cord-269011-230p8rsf	25	10	and	and	CC
cord-269011-230p8rsf	25	11	budding	budding	NN
cord-269011-230p8rsf	25	12	.	.	.
cord-269011-230p8rsf	26	1	The	the	DT
cord-269011-230p8rsf	26	2	main	main	JJ
cord-269011-230p8rsf	26	3	body	body	NN
cord-269011-230p8rsf	26	4	of	of	IN
cord-269011-230p8rsf	26	5	the	the	DT
cord-269011-230p8rsf	26	6	review	review	NN
cord-269011-230p8rsf	26	7	describes	describe	VBZ
cord-269011-230p8rsf	26	8	the	the	DT
cord-269011-230p8rsf	26	9	interactions	interaction	NNS
cord-269011-230p8rsf	26	10	between	between	IN
cord-269011-230p8rsf	26	11	the	the	DT
cord-269011-230p8rsf	26	12	different	different	JJ
cord-269011-230p8rsf	26	13	structural	structural	JJ
cord-269011-230p8rsf	26	14	components	component	NNS
cord-269011-230p8rsf	26	15	of	of	IN
cord-269011-230p8rsf	26	16	the	the	DT
cord-269011-230p8rsf	26	17	viruses	virus	NNS
cord-269011-230p8rsf	26	18	and	and	CC
cord-269011-230p8rsf	26	19	discusses	discuss	VBZ
cord-269011-230p8rsf	26	20	their	-PRON-	PRP$
cord-269011-230p8rsf	26	21	relevance	relevance	NN
cord-269011-230p8rsf	26	22	for	for	IN
cord-269011-230p8rsf	26	23	the	the	DT
cord-269011-230p8rsf	26	24	process	process	NN
cord-269011-230p8rsf	26	25	of	of	IN
cord-269011-230p8rsf	26	26	virion	virion	NN
cord-269011-230p8rsf	26	27	formation	formation	NN
cord-269011-230p8rsf	26	28	.	.	.
cord-269011-230p8rsf	27	1	This	this	DT
cord-269011-230p8rsf	27	2	review	review	NN
cord-269011-230p8rsf	27	3	has	have	VBZ
cord-269011-230p8rsf	27	4	a	a	DT
cord-269011-230p8rsf	27	5	limited	limited	JJ
cord-269011-230p8rsf	27	6	scope	scope	NN
cord-269011-230p8rsf	27	7	;	;	:
cord-269011-230p8rsf	27	8	for	for	IN
cord-269011-230p8rsf	27	9	further	further	JJ
cord-269011-230p8rsf	27	10	information	information	NN
cord-269011-230p8rsf	27	11	about	about	IN
cord-269011-230p8rsf	27	12	other	other	JJ
cord-269011-230p8rsf	27	13	aspects	aspect	NNS
cord-269011-230p8rsf	27	14	of	of	IN
cord-269011-230p8rsf	27	15	coronavirus	coronavirus	NN
cord-269011-230p8rsf	27	16	biology	biology	NN
cord-269011-230p8rsf	27	17	the	the	DT
cord-269011-230p8rsf	27	18	reader	reader	NN
cord-269011-230p8rsf	27	19	is	be	VBZ
cord-269011-230p8rsf	27	20	referred	refer	VBN
cord-269011-230p8rsf	27	21	to	to	IN
cord-269011-230p8rsf	27	22	other	other	JJ
cord-269011-230p8rsf	27	23	reviews	review	NNS
cord-269011-230p8rsf	27	24	(	(	-LRB-
cord-269011-230p8rsf	27	25	de	de	FW
cord-269011-230p8rsf	27	26	Vries	Vries	NNP
cord-269011-230p8rsf	27	27	et	et	NNP
cord-269011-230p8rsf	27	28	al	al	NNP
cord-269011-230p8rsf	27	29	.	.	NNP
cord-269011-230p8rsf	27	30	,	,	,
cord-269011-230p8rsf	27	31	1997	1997	CD
cord-269011-230p8rsf	27	32	;	;	.
cord-269011-230p8rsf	28	1	Enjuanes	Enjuanes	NNP
cord-269011-230p8rsf	28	2	et	et	NNP
cord-269011-230p8rsf	28	3	al	al	NNP
cord-269011-230p8rsf	28	4	.	.	.
cord-269011-230p8rsf	29	1	,	,	,
cord-269011-230p8rsf	29	2	2001	2001	CD
cord-269011-230p8rsf	29	3	;	;	:
cord-269011-230p8rsf	29	4	Gallagher	Gallagher	NNP
cord-269011-230p8rsf	29	5	and	and	CC
cord-269011-230p8rsf	29	6	Buchmeier	Buchmeier	NNP
cord-269011-230p8rsf	29	7	,	,	,
cord-269011-230p8rsf	29	8	2001	2001	CD
cord-269011-230p8rsf	29	9	;	;	:
cord-269011-230p8rsf	29	10	Holmes	Holmes	NNP
cord-269011-230p8rsf	29	11	,	,	,
cord-269011-230p8rsf	29	12	2001	2001	CD
cord-269011-230p8rsf	29	13	;	;	:
cord-269011-230p8rsf	29	14	Holmes	Holmes	NNP
cord-269011-230p8rsf	29	15	et	et	NNP
cord-269011-230p8rsf	29	16	al	al	NNP
cord-269011-230p8rsf	29	17	.	.	NNP
cord-269011-230p8rsf	29	18	,	,	,
cord-269011-230p8rsf	29	19	2001	2001	CD
cord-269011-230p8rsf	29	20	;	;	:
cord-269011-230p8rsf	29	21	Lai	Lai	NNP
cord-269011-230p8rsf	29	22	,	,	,
cord-269011-230p8rsf	29	23	1997	1997	CD
cord-269011-230p8rsf	29	24	;	;	:
cord-269011-230p8rsf	29	25	Lai	Lai	NNP
cord-269011-230p8rsf	29	26	and	and	CC
cord-269011-230p8rsf	29	27	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	29	28	,	,	,
cord-269011-230p8rsf	29	29	1997	1997	CD
cord-269011-230p8rsf	29	30	;	;	:
cord-269011-230p8rsf	29	31	Lai	Lai	NNP
cord-269011-230p8rsf	29	32	et	et	FW
cord-269011-230p8rsf	29	33	al	al	NNP
cord-269011-230p8rsf	29	34	.	.	.
cord-269011-230p8rsf	30	1	,	,	,
cord-269011-230p8rsf	30	2	1994	1994	CD
cord-269011-230p8rsf	30	3	;	;	:
cord-269011-230p8rsf	30	4	Masters	Masters	NNPS
cord-269011-230p8rsf	30	5	,	,	,
cord-269011-230p8rsf	30	6	1999	1999	CD
cord-269011-230p8rsf	30	7	;	;	:
cord-269011-230p8rsf	30	8	Perlman	Perlman	NNP
cord-269011-230p8rsf	30	9	,	,	,
cord-269011-230p8rsf	30	10	1998	1998	CD
cord-269011-230p8rsf	30	11	;	;	:
cord-269011-230p8rsf	30	12	Rossen	Rossen	NNP
cord-269011-230p8rsf	30	13	et	et	NNP
cord-269011-230p8rsf	30	14	al	al	NNP
cord-269011-230p8rsf	30	15	.	.	NNP
cord-269011-230p8rsf	30	16	,	,	,
cord-269011-230p8rsf	30	17	1995	1995	CD
cord-269011-230p8rsf	30	18	;	;	:
cord-269011-230p8rsf	30	19	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	30	20	and	and	CC
cord-269011-230p8rsf	30	21	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	30	22	,	,	,
cord-269011-230p8rsf	30	23	1998	1998	CD
cord-269011-230p8rsf	30	24	;	;	:
cord-269011-230p8rsf	30	25	Siddell	Siddell	NNP
cord-269011-230p8rsf	30	26	,	,	,
cord-269011-230p8rsf	30	27	1995	1995	CD
cord-269011-230p8rsf	30	28	;	;	:
cord-269011-230p8rsf	30	29	Ziebuhr	Ziebuhr	NNP
cord-269011-230p8rsf	30	30	et	et	NNP
cord-269011-230p8rsf	30	31	al	al	NNP
cord-269011-230p8rsf	30	32	.	.	NNP
cord-269011-230p8rsf	30	33	,	,	,
cord-269011-230p8rsf	30	34	2000	2000	CD
cord-269011-230p8rsf	30	35	)	)	-RRB-
cord-269011-230p8rsf	30	36	.	.	.
cord-269011-230p8rsf	31	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	31	2	are	be	VBP
cord-269011-230p8rsf	31	3	a	a	DT
cord-269011-230p8rsf	31	4	group	group	NN
cord-269011-230p8rsf	31	5	of	of	IN
cord-269011-230p8rsf	31	6	enveloped	envelop	VBN
cord-269011-230p8rsf	31	7	,	,	,
cord-269011-230p8rsf	31	8	plus	plus	CC
cord-269011-230p8rsf	31	9	-	-	HYPH
cord-269011-230p8rsf	31	10	stranded	strand	VBN
cord-269011-230p8rsf	31	11	RNA	RNA	NNP
cord-269011-230p8rsf	31	12	viruses	virus	NNS
cord-269011-230p8rsf	31	13	presently	presently	RB
cord-269011-230p8rsf	31	14	classified	classify	VBN
cord-269011-230p8rsf	31	15	as	as	IN
cord-269011-230p8rsf	31	16	a	a	DT
cord-269011-230p8rsf	31	17	genus	genus	NN
cord-269011-230p8rsf	31	18	,	,	,
cord-269011-230p8rsf	31	19	which	which	WDT
cord-269011-230p8rsf	31	20	,	,	,
cord-269011-230p8rsf	31	21	together	together	RB
cord-269011-230p8rsf	31	22	with	with	IN
cord-269011-230p8rsf	31	23	the	the	DT
cord-269011-230p8rsf	31	24	genus	genus	NN
cord-269011-230p8rsf	31	25	Torovirus	Torovirus	NNP
cord-269011-230p8rsf	31	26	,	,	,
cord-269011-230p8rsf	31	27	constitutes	constitute	VBZ
cord-269011-230p8rsf	31	28	the	the	DT
cord-269011-230p8rsf	31	29	family	family	NN
cord-269011-230p8rsf	31	30	Coronaviridae	Coronaviridae	NNP
cord-269011-230p8rsf	31	31	.	.	.
cord-269011-230p8rsf	32	1	These	these	DT
cord-269011-230p8rsf	32	2	viruses	virus	NNS
cord-269011-230p8rsf	32	3	are	be	VBP
cord-269011-230p8rsf	32	4	grouped	group	VBN
cord-269011-230p8rsf	32	5	with	with	IN
cord-269011-230p8rsf	32	6	two	two	CD
cord-269011-230p8rsf	32	7	other	other	JJ
cord-269011-230p8rsf	32	8	families	family	NNS
cord-269011-230p8rsf	32	9	,	,	,
cord-269011-230p8rsf	32	10	the	the	DT
cord-269011-230p8rsf	32	11	Arteriviridae	Arteriviridae	NNP
cord-269011-230p8rsf	32	12	and	and	CC
cord-269011-230p8rsf	32	13	the	the	DT
cord-269011-230p8rsf	32	14	Roniviridae	Roniviridae	NNP
cord-269011-230p8rsf	32	15	,	,	,
cord-269011-230p8rsf	32	16	into	into	IN
cord-269011-230p8rsf	32	17	the	the	DT
cord-269011-230p8rsf	32	18	order	order	NN
cord-269011-230p8rsf	32	19	Nidovirales	Nidovirales	NNP
cord-269011-230p8rsf	32	20	.	.	.
cord-269011-230p8rsf	33	1	This	this	DT
cord-269011-230p8rsf	33	2	classification	classification	NN
cord-269011-230p8rsf	33	3	is	be	VBZ
cord-269011-230p8rsf	33	4	not	not	RB
cord-269011-230p8rsf	33	5	based	base	VBN
cord-269011-230p8rsf	33	6	on	on	IN
cord-269011-230p8rsf	33	7	structural	structural	JJ
cord-269011-230p8rsf	33	8	similarities	similarity	NNS
cord-269011-230p8rsf	33	9	-	-	:
cord-269011-230p8rsf	33	10	in	in	RP
cord-269011-230p8rsf	33	11	fact	fact	NN
cord-269011-230p8rsf	33	12	,	,	,
cord-269011-230p8rsf	33	13	structure	structure	NN
cord-269011-230p8rsf	33	14	and	and	CC
cord-269011-230p8rsf	33	15	composition	composition	NN
cord-269011-230p8rsf	33	16	of	of	IN
cord-269011-230p8rsf	33	17	the	the	DT
cord-269011-230p8rsf	33	18	viruses	virus	NNS
cord-269011-230p8rsf	33	19	from	from	IN
cord-269011-230p8rsf	33	20	the	the	DT
cord-269011-230p8rsf	33	21	different	different	JJ
cord-269011-230p8rsf	33	22	families	family	NNS
cord-269011-230p8rsf	33	23	differ	differ	VBP
cord-269011-230p8rsf	33	24	significantly	significantly	RB
cord-269011-230p8rsf	33	25	-	-	:
cord-269011-230p8rsf	33	26	but	but	CC
cord-269011-230p8rsf	33	27	on	on	IN
cord-269011-230p8rsf	33	28	common	common	JJ
cord-269011-230p8rsf	33	29	features	feature	NNS
cord-269011-230p8rsf	33	30	of	of	IN
cord-269011-230p8rsf	33	31	genome	genome	NN
cord-269011-230p8rsf	33	32	organization	organization	NN
cord-269011-230p8rsf	33	33	and	and	CC
cord-269011-230p8rsf	33	34	gene	gene	NN
cord-269011-230p8rsf	33	35	expression	expression	NN
cord-269011-230p8rsf	33	36	(	(	-LRB-
cord-269011-230p8rsf	34	1	de	de	NNP
cord-269011-230p8rsf	34	2	Vries	Vries	NNP
cord-269011-230p8rsf	34	3	et	et	NNP
cord-269011-230p8rsf	34	4	al	al	NNP
cord-269011-230p8rsf	34	5	.	.	.
cord-269011-230p8rsf	35	1	,	,	,
cord-269011-230p8rsf	35	2	1997	1997	CD
cord-269011-230p8rsf	35	3	;	;	:
cord-269011-230p8rsf	35	4	Lai	Lai	NNP
cord-269011-230p8rsf	35	5	and	and	CC
cord-269011-230p8rsf	35	6	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	35	7	,	,	,
cord-269011-230p8rsf	35	8	1997	1997	CD
cord-269011-230p8rsf	35	9	)	)	-RRB-
cord-269011-230p8rsf	35	10	.	.	.
cord-269011-230p8rsf	36	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	36	2	infect	infect	VBP
cord-269011-230p8rsf	36	3	a	a	DT
cord-269011-230p8rsf	36	4	wide	wide	JJ
cord-269011-230p8rsf	36	5	variety	variety	NN
cord-269011-230p8rsf	36	6	of	of	IN
cord-269011-230p8rsf	36	7	mammals	mammal	NNS
cord-269011-230p8rsf	36	8	as	as	RB
cord-269011-230p8rsf	36	9	well	well	RB
cord-269011-230p8rsf	36	10	as	as	IN
cord-269011-230p8rsf	36	11	avian	avian	JJ
cord-269011-230p8rsf	36	12	species	specie	NNS
cord-269011-230p8rsf	37	1	(	(	-LRB-
cord-269011-230p8rsf	37	2	Table	table	NN
cord-269011-230p8rsf	37	3	I	i	CD
cord-269011-230p8rsf	37	4	)	)	-RRB-
cord-269011-230p8rsf	37	5	.	.	.
cord-269011-230p8rsf	38	1	In	in	IN
cord-269011-230p8rsf	38	2	general	general	JJ
cord-269011-230p8rsf	38	3	they	-PRON-	PRP
cord-269011-230p8rsf	38	4	cause	cause	VBP
cord-269011-230p8rsf	38	5	respiratory	respiratory	JJ
cord-269011-230p8rsf	38	6	or	or	CC
cord-269011-230p8rsf	38	7	intestinal	intestinal	JJ
cord-269011-230p8rsf	38	8	infections	infection	NNS
cord-269011-230p8rsf	38	9	,	,	,
cord-269011-230p8rsf	38	10	but	but	CC
cord-269011-230p8rsf	38	11	some	some	DT
cord-269011-230p8rsf	38	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	38	13	can	can	MD
cord-269011-230p8rsf	38	14	also	also	RB
cord-269011-230p8rsf	38	15	infect	infect	VB
cord-269011-230p8rsf	38	16	other	other	JJ
cord-269011-230p8rsf	38	17	organs	organ	NNS
cord-269011-230p8rsf	38	18	(	(	-LRB-
cord-269011-230p8rsf	38	19	liver	liver	NN
cord-269011-230p8rsf	38	20	,	,	,
cord-269011-230p8rsf	38	21	kidney	kidney	NN
cord-269011-230p8rsf	38	22	,	,	,
cord-269011-230p8rsf	38	23	and	and	CC
cord-269011-230p8rsf	38	24	brain	brain	NN
cord-269011-230p8rsf	38	25	)	)	-RRB-
cord-269011-230p8rsf	38	26	.	.	.
cord-269011-230p8rsf	39	1	Until	until	IN
cord-269011-230p8rsf	39	2	recently	recently	RB
cord-269011-230p8rsf	39	3	,	,	,
cord-269011-230p8rsf	39	4	these	these	DT
cord-269011-230p8rsf	39	5	viruses	virus	NNS
cord-269011-230p8rsf	39	6	were	be	VBD
cord-269011-230p8rsf	39	7	mainly	mainly	RB
cord-269011-230p8rsf	39	8	of	of	IN
cord-269011-230p8rsf	39	9	veterinary	veterinary	JJ
cord-269011-230p8rsf	39	10	importance	importance	NN
cord-269011-230p8rsf	39	11	.	.	.
cord-269011-230p8rsf	40	1	This	this	DT
cord-269011-230p8rsf	40	2	situation	situation	NN
cord-269011-230p8rsf	40	3	has	have	VBZ
cord-269011-230p8rsf	40	4	changed	change	VBN
cord-269011-230p8rsf	40	5	quite	quite	RB
cord-269011-230p8rsf	40	6	dramatically	dramatically	RB
cord-269011-230p8rsf	40	7	because	because	IN
cord-269011-230p8rsf	40	8	of	of	IN
cord-269011-230p8rsf	40	9	the	the	DT
cord-269011-230p8rsf	40	10	emergence	emergence	NN
cord-269011-230p8rsf	40	11	of	of	IN
cord-269011-230p8rsf	40	12	severe	severe	JJ
cord-269011-230p8rsf	40	13	acute	acute	JJ
cord-269011-230p8rsf	40	14	respiratory	respiratory	JJ
cord-269011-230p8rsf	40	15	syndrome-	syndrome-	NN
cord-269011-230p8rsf	41	1	(	(	-LRB-
cord-269011-230p8rsf	41	2	SARS	SARS	NNP
cord-269011-230p8rsf	41	3	-	-	HYPH
cord-269011-230p8rsf	41	4	CoV	CoV	NNP
cord-269011-230p8rsf	41	5	)	)	-RRB-
cord-269011-230p8rsf	41	6	in	in	IN
cord-269011-230p8rsf	41	7	late	late	JJ
cord-269011-230p8rsf	41	8	2002	2002	CD
cord-269011-230p8rsf	41	9	,	,	,
cord-269011-230p8rsf	41	10	which	which	WDT
cord-269011-230p8rsf	41	11	emphasized	emphasize	VBD
cord-269011-230p8rsf	41	12	the	the	DT
cord-269011-230p8rsf	41	13	potential	potential	JJ
cord-269011-230p8rsf	41	14	relevance	relevance	NN
cord-269011-230p8rsf	41	15	of	of	IN
cord-269011-230p8rsf	41	16	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	41	17	for	for	IN
cord-269011-230p8rsf	41	18	humans	human	NNS
cord-269011-230p8rsf	41	19	.	.	.
cord-269011-230p8rsf	42	1	On	on	IN
cord-269011-230p8rsf	42	2	the	the	DT
cord-269011-230p8rsf	42	3	basis	basis	NN
cord-269011-230p8rsf	42	4	of	of	IN
cord-269011-230p8rsf	42	5	antigenic	antigenic	JJ
cord-269011-230p8rsf	42	6	and	and	CC
cord-269011-230p8rsf	42	7	genetic	genetic	JJ
cord-269011-230p8rsf	42	8	relationships	relationship	NNS
cord-269011-230p8rsf	42	9	the	the	DT
cord-269011-230p8rsf	42	10	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	42	11	have	have	VBP
cord-269011-230p8rsf	42	12	been	be	VBN
cord-269011-230p8rsf	42	13	subdivided	subdivide	VBN
cord-269011-230p8rsf	42	14	into	into	IN
cord-269011-230p8rsf	42	15	three	three	CD
cord-269011-230p8rsf	42	16	groups	group	NNS
cord-269011-230p8rsf	42	17	(	(	-LRB-
cord-269011-230p8rsf	42	18	Table	table	NN
cord-269011-230p8rsf	42	19	I	-PRON-	PRP
cord-269011-230p8rsf	42	20	)	)	-RRB-
cord-269011-230p8rsf	42	21	;	;	:
cord-269011-230p8rsf	42	22	the	the	DT
cord-269011-230p8rsf	42	23	taxonomic	taxonomic	JJ
cord-269011-230p8rsf	42	24	position	position	NN
cord-269011-230p8rsf	42	25	of	of	IN
cord-269011-230p8rsf	42	26	SARS	SARS	NNP
cord-269011-230p8rsf	42	27	-	-	HYPH
cord-269011-230p8rsf	42	28	CoV	CoV	NNP
cord-269011-230p8rsf	42	29	has	have	VBZ
cord-269011-230p8rsf	42	30	not	not	RB
cord-269011-230p8rsf	42	31	been	be	VBN
cord-269011-230p8rsf	42	32	formally	formally	RB
cord-269011-230p8rsf	42	33	assigned	assign	VBN
cord-269011-230p8rsf	42	34	.	.	.
cord-269011-230p8rsf	43	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	43	2	particles	particle	NNS
cord-269011-230p8rsf	43	3	have	have	VBP
cord-269011-230p8rsf	43	4	a	a	DT
cord-269011-230p8rsf	43	5	typical	typical	JJ
cord-269011-230p8rsf	43	6	appearance	appearance	NN
cord-269011-230p8rsf	43	7	under	under	IN
cord-269011-230p8rsf	43	8	the	the	DT
cord-269011-230p8rsf	43	9	electron	electron	NN
cord-269011-230p8rsf	43	10	microscope	microscope	NN
cord-269011-230p8rsf	43	11	.	.	.
cord-269011-230p8rsf	44	1	By	by	IN
cord-269011-230p8rsf	44	2	the	the	DT
cord-269011-230p8rsf	44	3	characteristic	characteristic	NN
cord-269011-230p8rsf	44	4	,	,	,
cord-269011-230p8rsf	44	5	approximately	approximately	RB
cord-269011-230p8rsf	44	6	20-nm	20-nm	CD
cord-269011-230p8rsf	44	7	-	-	HYPH
cord-269011-230p8rsf	44	8	long	long	JJ
cord-269011-230p8rsf	44	9	spikes	spike	NNS
cord-269011-230p8rsf	44	10	that	that	WDT
cord-269011-230p8rsf	44	11	emanate	emanate	VBP
cord-269011-230p8rsf	44	12	from	from	IN
cord-269011-230p8rsf	44	13	their	-PRON-	PRP$
cord-269011-230p8rsf	44	14	envelope	envelope	NN
cord-269011-230p8rsf	44	15	the	the	DT
cord-269011-230p8rsf	44	16	viruses	virus	NNS
cord-269011-230p8rsf	44	17	acquire	acquire	VBP
cord-269011-230p8rsf	44	18	the	the	DT
cord-269011-230p8rsf	44	19	solar	solar	JJ
cord-269011-230p8rsf	44	20	image	image	NN
cord-269011-230p8rsf	44	21	to	to	TO
cord-269011-230p8rsf	44	22	which	which	WDT
cord-269011-230p8rsf	44	23	they	-PRON-	PRP
cord-269011-230p8rsf	44	24	owe	owe	VBP
cord-269011-230p8rsf	44	25	their	-PRON-	PRP$
cord-269011-230p8rsf	44	26	name	name	NN
cord-269011-230p8rsf	44	27	(	(	-LRB-
cord-269011-230p8rsf	44	28	Fig	Fig	NNP
cord-269011-230p8rsf	44	29	.	.	.
cord-269011-230p8rsf	44	30	1	1	CD
cord-269011-230p8rsf	44	31	)	)	-RRB-
cord-269011-230p8rsf	44	32	.	.	.
cord-269011-230p8rsf	45	1	The	the	DT
cord-269011-230p8rsf	45	2	80-to	80-to	CD
cord-269011-230p8rsf	45	3	120-nm	120-nm	CD
cord-269011-230p8rsf	45	4	virions	virion	NNS
cord-269011-230p8rsf	45	5	have	have	VBP
cord-269011-230p8rsf	45	6	a	a	DT
cord-269011-230p8rsf	45	7	pleiomorphic	pleiomorphic	JJ
cord-269011-230p8rsf	45	8	appearance	appearance	NN
cord-269011-230p8rsf	45	9	that	that	IN
cord-269011-230p8rsf	45	10	,	,	,
cord-269011-230p8rsf	45	11	whether	whether	IN
cord-269011-230p8rsf	45	12	artifact	artifact	NN
cord-269011-230p8rsf	45	13	or	or	CC
cord-269011-230p8rsf	45	14	real	real	JJ
cord-269011-230p8rsf	45	15	,	,	,
cord-269011-230p8rsf	45	16	reflects	reflect	VBZ
cord-269011-230p8rsf	45	17	a	a	DT
cord-269011-230p8rsf	45	18	pliable	pliable	JJ
cord-269011-230p8rsf	45	19	constellation	constellation	NN
cord-269011-230p8rsf	45	20	,	,	,
cord-269011-230p8rsf	45	21	a	a	DT
cord-269011-230p8rsf	45	22	feature	feature	NN
cord-269011-230p8rsf	45	23	that	that	WDT
cord-269011-230p8rsf	45	24	has	have	VBZ
cord-269011-230p8rsf	45	25	severely	severely	RB
cord-269011-230p8rsf	45	26	hampered	hamper	VBN
cord-269011-230p8rsf	45	27	the	the	DT
cord-269011-230p8rsf	45	28	ultrastructural	ultrastructural	JJ
cord-269011-230p8rsf	45	29	analysis	analysis	NN
cord-269011-230p8rsf	45	30	of	of	IN
cord-269011-230p8rsf	45	31	these	these	DT
cord-269011-230p8rsf	45	32	viruses	virus	NNS
cord-269011-230p8rsf	45	33	.	.	.
cord-269011-230p8rsf	46	1	Hence	hence	RB
cord-269011-230p8rsf	46	2	,	,	,
cord-269011-230p8rsf	46	3	our	-PRON-	PRP$
cord-269011-230p8rsf	46	4	knowledge	knowledge	NN
cord-269011-230p8rsf	46	5	about	about	IN
cord-269011-230p8rsf	46	6	the	the	DT
cord-269011-230p8rsf	46	7	structure	structure	NN
cord-269011-230p8rsf	46	8	of	of	IN
cord-269011-230p8rsf	46	9	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	46	10	is	be	VBZ
cord-269011-230p8rsf	46	11	still	still	RB
cord-269011-230p8rsf	46	12	rudimentary	rudimentary	JJ
cord-269011-230p8rsf	46	13	.	.	.
cord-269011-230p8rsf	47	1	The	the	DT
cord-269011-230p8rsf	47	2	schematic	schematic	JJ
cord-269011-230p8rsf	47	3	representation	representation	NN
cord-269011-230p8rsf	47	4	of	of	IN
cord-269011-230p8rsf	47	5	the	the	DT
cord-269011-230p8rsf	47	6	current	current	JJ
cord-269011-230p8rsf	47	7	model	model	NN
cord-269011-230p8rsf	47	8	of	of	IN
cord-269011-230p8rsf	47	9	the	the	DT
cord-269011-230p8rsf	47	10	coronavirion	coronavirion	NN
cord-269011-230p8rsf	47	11	drawn	draw	VBN
cord-269011-230p8rsf	47	12	in	in	IN
cord-269011-230p8rsf	47	13	Fig	Fig	NNP
cord-269011-230p8rsf	47	14	.	.	.
cord-269011-230p8rsf	48	1	1	1	CD
cord-269011-230p8rsf	48	2	is	be	VBZ
cord-269011-230p8rsf	48	3	based	base	VBN
cord-269011-230p8rsf	48	4	on	on	IN
cord-269011-230p8rsf	48	5	morphological	morphological	JJ
cord-269011-230p8rsf	48	6	and	and	CC
cord-269011-230p8rsf	48	7	biochemical	biochemical	JJ
cord-269011-230p8rsf	48	8	FIG	fig	NN
cord-269011-230p8rsf	48	9	1	1	CD
cord-269011-230p8rsf	48	10	.	.	.
cord-269011-230p8rsf	49	1	Electron	electron	NN
cord-269011-230p8rsf	49	2	micrographs	micrograph	NNS
cord-269011-230p8rsf	49	3	of	of	IN
cord-269011-230p8rsf	49	4	mouse	mouse	NNP
cord-269011-230p8rsf	49	5	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	49	6	virus	virus	NN
cord-269011-230p8rsf	49	7	strain	strain	VBP
cord-269011-230p8rsf	49	8	A59	A59	NNP
cord-269011-230p8rsf	50	1	(	(	-LRB-
cord-269011-230p8rsf	50	2	MHV	MHV	NNP
cord-269011-230p8rsf	50	3	-	-	HYPH
cord-269011-230p8rsf	50	4	A59	A59	NNP
cord-269011-230p8rsf	50	5	)	)	-RRB-
cord-269011-230p8rsf	50	6	virions	virion	NNS
cord-269011-230p8rsf	50	7	without	without	IN
cord-269011-230p8rsf	50	8	(	(	-LRB-
cord-269011-230p8rsf	50	9	A	a	NN
cord-269011-230p8rsf	50	10	)	)	-RRB-
cord-269011-230p8rsf	50	11	and	and	CC
cord-269011-230p8rsf	50	12	with	with	IN
cord-269011-230p8rsf	50	13	(	(	-LRB-
cord-269011-230p8rsf	50	14	B	b	NN
cord-269011-230p8rsf	50	15	)	)	-RRB-
cord-269011-230p8rsf	51	1	the	the	DT
cord-269011-230p8rsf	51	2	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	51	3	-	-	HYPH
cord-269011-230p8rsf	51	4	esterase	esterase	NN
cord-269011-230p8rsf	51	5	(	(	-LRB-
cord-269011-230p8rsf	51	6	HE	he	NN
cord-269011-230p8rsf	51	7	)	)	-RRB-
cord-269011-230p8rsf	51	8	envelope	envelope	NN
cord-269011-230p8rsf	51	9	protein	protein	NN
cord-269011-230p8rsf	51	10	(	(	-LRB-
cord-269011-230p8rsf	51	11	viruses	virus	NNS
cord-269011-230p8rsf	51	12	kindly	kindly	RB
cord-269011-230p8rsf	51	13	provided	provide	VBN
cord-269011-230p8rsf	51	14	by	by	IN
cord-269011-230p8rsf	51	15	R.	R.	NNP
cord-269011-230p8rsf	51	16	de	de	NNP
cord-269011-230p8rsf	51	17	Groot	Groot	NNP
cord-269011-230p8rsf	51	18	,	,	,
cord-269011-230p8rsf	51	19	Virology	Virology	NNP
cord-269011-230p8rsf	51	20	Division	Division	NNP
cord-269011-230p8rsf	51	21	,	,	,
cord-269011-230p8rsf	51	22	Utrecht	Utrecht	NNP
cord-269011-230p8rsf	51	23	University	University	NNP
cord-269011-230p8rsf	51	24	,	,	,
cord-269011-230p8rsf	51	25	The	the	DT
cord-269011-230p8rsf	51	26	Netherlands	Netherlands	NNP
cord-269011-230p8rsf	51	27	;	;	:
cord-269011-230p8rsf	51	28	image	image	NN
cord-269011-230p8rsf	51	29	courtesy	courtesy	NN
cord-269011-230p8rsf	51	30	of	of	IN
cord-269011-230p8rsf	51	31	J.	J.	NNP
cord-269011-230p8rsf	51	32	Lepault	Lepault	NNP
cord-269011-230p8rsf	51	33	,	,	,
cord-269011-230p8rsf	51	34	VMS	VMS	NNP
cord-269011-230p8rsf	51	35	-	-	HYPH
cord-269011-230p8rsf	51	36	CNRS	CNRS	NNP
cord-269011-230p8rsf	51	37	,	,	,
cord-269011-230p8rsf	51	38	Gif	Gif	NNP
cord-269011-230p8rsf	51	39	-	-	HYPH
cord-269011-230p8rsf	51	40	sur	sur	NNP
cord-269011-230p8rsf	51	41	-	-	HYPH
cord-269011-230p8rsf	51	42	Yvette	Yvette	NNP
cord-269011-230p8rsf	51	43	,	,	,
cord-269011-230p8rsf	51	44	France	France	NNP
cord-269011-230p8rsf	51	45	)	)	-RRB-
cord-269011-230p8rsf	51	46	.	.	.
cord-269011-230p8rsf	52	1	Large	large	JJ
cord-269011-230p8rsf	52	2	,	,	,
cord-269011-230p8rsf	52	3	club	club	NN
cord-269011-230p8rsf	52	4	-	-	HYPH
cord-269011-230p8rsf	52	5	shaped	shape	VBN
cord-269011-230p8rsf	52	6	protrusions	protrusion	NNS
cord-269011-230p8rsf	52	7	consisting	consist	VBG
cord-269011-230p8rsf	52	8	of	of	IN
cord-269011-230p8rsf	52	9	spike	spike	NN
cord-269011-230p8rsf	52	10	(	(	-LRB-
cord-269011-230p8rsf	52	11	S	s	NN
cord-269011-230p8rsf	52	12	)	)	-RRB-
cord-269011-230p8rsf	52	13	protein	protein	NN
cord-269011-230p8rsf	52	14	trimers	trimer	NNS
cord-269011-230p8rsf	52	15	give	give	VBP
cord-269011-230p8rsf	52	16	the	the	DT
cord-269011-230p8rsf	52	17	viruses	virus	NNS
cord-269011-230p8rsf	52	18	their	-PRON-	PRP$
cord-269011-230p8rsf	52	19	corona	corona	NN
cord-269011-230p8rsf	52	20	solis	solis	NNP
cord-269011-230p8rsf	52	21	-	-	HYPH
cord-269011-230p8rsf	52	22	like	like	JJ
cord-269011-230p8rsf	52	23	appearance	appearance	NN
cord-269011-230p8rsf	52	24	.	.	.
cord-269011-230p8rsf	53	1	Viruses	virus	NNS
cord-269011-230p8rsf	53	2	containing	contain	VBG
cord-269011-230p8rsf	53	3	the	the	DT
cord-269011-230p8rsf	53	4	HE	HE	NNP
cord-269011-230p8rsf	53	5	protein	protein	NN
cord-269011-230p8rsf	53	6	display	display	NN
cord-269011-230p8rsf	53	7	a	a	DT
cord-269011-230p8rsf	53	8	second	second	JJ
cord-269011-230p8rsf	53	9	,	,	,
cord-269011-230p8rsf	53	10	shorter	short	JJR
cord-269011-230p8rsf	53	11	fringe	fringe	NN
cord-269011-230p8rsf	53	12	of	of	IN
cord-269011-230p8rsf	53	13	surface	surface	NN
cord-269011-230p8rsf	53	14	projections	projection	NNS
cord-269011-230p8rsf	53	15	in	in	IN
cord-269011-230p8rsf	53	16	addition	addition	NN
cord-269011-230p8rsf	53	17	to	to	IN
cord-269011-230p8rsf	53	18	the	the	DT
cord-269011-230p8rsf	53	19	spikes	spike	NNS
cord-269011-230p8rsf	53	20	.	.	.
cord-269011-230p8rsf	54	1	(	(	-LRB-
cord-269011-230p8rsf	54	2	C	C	NNP
cord-269011-230p8rsf	54	3	)	)	-RRB-
cord-269011-230p8rsf	54	4	Schematic	schematic	JJ
cord-269011-230p8rsf	54	5	representation	representation	NN
cord-269011-230p8rsf	54	6	of	of	IN
cord-269011-230p8rsf	54	7	the	the	DT
cord-269011-230p8rsf	54	8	coronavirion	coronavirion	NN
cord-269011-230p8rsf	54	9	.	.	.
cord-269011-230p8rsf	55	1	The	the	DT
cord-269011-230p8rsf	55	2	viral	viral	JJ
cord-269011-230p8rsf	55	3	RNA	RNA	NNP
cord-269011-230p8rsf	55	4	is	be	VBZ
cord-269011-230p8rsf	55	5	encapsidated	encapsidate	VBN
cord-269011-230p8rsf	55	6	by	by	IN
cord-269011-230p8rsf	55	7	the	the	DT
cord-269011-230p8rsf	55	8	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	55	9	(	(	-LRB-
cord-269011-230p8rsf	55	10	N	N	NNP
cord-269011-230p8rsf	55	11	)	)	-RRB-
cord-269011-230p8rsf	55	12	protein	protein	NN
cord-269011-230p8rsf	55	13	forming	form	VBG
cord-269011-230p8rsf	55	14	a	a	DT
cord-269011-230p8rsf	55	15	helical	helical	JJ
cord-269011-230p8rsf	55	16	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	55	17	(	(	-LRB-
cord-269011-230p8rsf	55	18	RNP	RNP	NNP
cord-269011-230p8rsf	55	19	)	)	-RRB-
cord-269011-230p8rsf	55	20	,	,	,
cord-269011-230p8rsf	55	21	which	which	WDT
cord-269011-230p8rsf	55	22	is	be	VBZ
cord-269011-230p8rsf	55	23	in	in	IN
cord-269011-230p8rsf	55	24	turn	turn	NN
cord-269011-230p8rsf	55	25	part	part	NN
cord-269011-230p8rsf	55	26	of	of	IN
cord-269011-230p8rsf	55	27	a	a	DT
cord-269011-230p8rsf	55	28	structure	structure	NN
cord-269011-230p8rsf	55	29	with	with	IN
cord-269011-230p8rsf	55	30	spherical	spherical	JJ
cord-269011-230p8rsf	55	31	,	,	,
cord-269011-230p8rsf	55	32	probably	probably	RB
cord-269011-230p8rsf	55	33	icosahedral	icosahedral	JJ
cord-269011-230p8rsf	55	34	,	,	,
cord-269011-230p8rsf	55	35	configuration	configuration	NN
cord-269011-230p8rsf	55	36	.	.	.
cord-269011-230p8rsf	56	1	The	the	DT
cord-269011-230p8rsf	56	2	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	56	3	is	be	VBZ
cord-269011-230p8rsf	56	4	surrounded	surround	VBN
cord-269011-230p8rsf	56	5	by	by	IN
cord-269011-230p8rsf	56	6	a	a	DT
cord-269011-230p8rsf	56	7	lipid	lipid	NN
cord-269011-230p8rsf	56	8	bilayer	bilayer	NN
cord-269011-230p8rsf	56	9	in	in	IN
cord-269011-230p8rsf	56	10	which	which	WDT
cord-269011-230p8rsf	56	11	the	the	DT
cord-269011-230p8rsf	56	12	S	S	NNP
cord-269011-230p8rsf	56	13	protein	protein	NN
cord-269011-230p8rsf	56	14	,	,	,
cord-269011-230p8rsf	56	15	the	the	DT
cord-269011-230p8rsf	56	16	membrane	membrane	NN
cord-269011-230p8rsf	56	17	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	56	18	(	(	-LRB-
cord-269011-230p8rsf	56	19	M	M	NNP
cord-269011-230p8rsf	56	20	)	)	-RRB-
cord-269011-230p8rsf	56	21	,	,	,
cord-269011-230p8rsf	56	22	and	and	CC
cord-269011-230p8rsf	56	23	the	the	DT
cord-269011-230p8rsf	56	24	envelope	envelope	NN
cord-269011-230p8rsf	56	25	protein	protein	NN
cord-269011-230p8rsf	56	26	(	(	-LRB-
cord-269011-230p8rsf	56	27	E	E	NNP
cord-269011-230p8rsf	56	28	)	)	-RRB-
cord-269011-230p8rsf	56	29	are	be	VBP
cord-269011-230p8rsf	56	30	anchored	anchor	VBN
cord-269011-230p8rsf	56	31	.	.	.
cord-269011-230p8rsf	57	1	In	in	IN
cord-269011-230p8rsf	57	2	addition	addition	NN
cord-269011-230p8rsf	57	3	,	,	,
cord-269011-230p8rsf	57	4	some	some	DT
cord-269011-230p8rsf	57	5	group	group	NN
cord-269011-230p8rsf	57	6	2	2	CD
cord-269011-230p8rsf	57	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	57	8	contain	contain	VBP
cord-269011-230p8rsf	57	9	the	the	DT
cord-269011-230p8rsf	57	10	HE	HE	NNP
cord-269011-230p8rsf	57	11	protein	protein	NN
cord-269011-230p8rsf	57	12	in	in	IN
cord-269011-230p8rsf	57	13	their	-PRON-	PRP$
cord-269011-230p8rsf	57	14	lipid	lipid	NN
cord-269011-230p8rsf	57	15	envelope	envelope	NN
cord-269011-230p8rsf	57	16	as	as	IN
cord-269011-230p8rsf	57	17	illustrated	illustrate	VBN
cord-269011-230p8rsf	57	18	on	on	IN
cord-269011-230p8rsf	57	19	the	the	DT
cord-269011-230p8rsf	57	20	right	right	JJ
cord-269011-230p8rsf	57	21	side	side	NN
cord-269011-230p8rsf	57	22	of	of	IN
cord-269011-230p8rsf	57	23	the	the	DT
cord-269011-230p8rsf	57	24	particle	particle	NN
cord-269011-230p8rsf	57	25	.	.	.
cord-269011-230p8rsf	58	1	observations	observation	NNS
cord-269011-230p8rsf	58	2	.	.	.
cord-269011-230p8rsf	59	1	As	as	IN
cord-269011-230p8rsf	59	2	this	this	DT
cord-269011-230p8rsf	59	3	picture	picture	NN
cord-269011-230p8rsf	59	4	illustrates	illustrate	VBZ
cord-269011-230p8rsf	59	5	,	,	,
cord-269011-230p8rsf	59	6	the	the	DT
cord-269011-230p8rsf	59	7	particle	particle	NN
cord-269011-230p8rsf	59	8	consists	consist	VBZ
cord-269011-230p8rsf	59	9	of	of	IN
cord-269011-230p8rsf	59	10	a	a	DT
cord-269011-230p8rsf	59	11	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	59	12	or	or	CC
cord-269011-230p8rsf	59	13	core	core	NN
cord-269011-230p8rsf	59	14	structure	structure	NN
cord-269011-230p8rsf	59	15	that	that	WDT
cord-269011-230p8rsf	59	16	is	be	VBZ
cord-269011-230p8rsf	59	17	surrounded	surround	VBN
cord-269011-230p8rsf	59	18	by	by	IN
cord-269011-230p8rsf	59	19	a	a	DT
cord-269011-230p8rsf	59	20	lipid	lipid	NN
cord-269011-230p8rsf	59	21	envelope	envelope	NN
cord-269011-230p8rsf	59	22	.	.	.
cord-269011-230p8rsf	60	1	Anchored	anchor	VBN
cord-269011-230p8rsf	60	2	in	in	IN
cord-269011-230p8rsf	60	3	this	this	DT
cord-269011-230p8rsf	60	4	envelope	envelope	NN
cord-269011-230p8rsf	60	5	are	be	VBP
cord-269011-230p8rsf	60	6	the	the	DT
cord-269011-230p8rsf	60	7	three	three	CD
cord-269011-230p8rsf	60	8	canonical	canonical	JJ
cord-269011-230p8rsf	60	9	coronavirus	coronavirus	NN
cord-269011-230p8rsf	60	10	membrane	membrane	NN
cord-269011-230p8rsf	60	11	proteins	protein	NNS
cord-269011-230p8rsf	60	12	:	:	:
cord-269011-230p8rsf	60	13	the	the	DT
cord-269011-230p8rsf	60	14	membrane	membrane	NN
cord-269011-230p8rsf	60	15	(	(	-LRB-
cord-269011-230p8rsf	60	16	M	M	NNP
cord-269011-230p8rsf	60	17	)	)	-RRB-
cord-269011-230p8rsf	60	18	protein	protein	NN
cord-269011-230p8rsf	60	19	,	,	,
cord-269011-230p8rsf	60	20	the	the	DT
cord-269011-230p8rsf	60	21	envelope	envelope	NN
cord-269011-230p8rsf	60	22	(	(	-LRB-
cord-269011-230p8rsf	60	23	E	e	NN
cord-269011-230p8rsf	60	24	)	)	-RRB-
cord-269011-230p8rsf	60	25	protein	protein	NN
cord-269011-230p8rsf	60	26	,	,	,
cord-269011-230p8rsf	60	27	and	and	CC
cord-269011-230p8rsf	60	28	the	the	DT
cord-269011-230p8rsf	60	29	spike	spike	NN
cord-269011-230p8rsf	60	30	(	(	-LRB-
cord-269011-230p8rsf	60	31	S	s	NN
cord-269011-230p8rsf	60	32	)	)	-RRB-
cord-269011-230p8rsf	60	33	protein	protein	NN
cord-269011-230p8rsf	60	34	.	.	.
cord-269011-230p8rsf	61	1	Viruses	virus	NNS
cord-269011-230p8rsf	61	2	from	from	IN
cord-269011-230p8rsf	61	3	group	group	NN
cord-269011-230p8rsf	61	4	2	2	CD
cord-269011-230p8rsf	61	5	have	have	VBP
cord-269011-230p8rsf	61	6	an	an	DT
cord-269011-230p8rsf	61	7	additional	additional	JJ
cord-269011-230p8rsf	61	8	,	,	,
cord-269011-230p8rsf	61	9	fourth	fourth	JJ
cord-269011-230p8rsf	61	10	membrane	membrane	NN
cord-269011-230p8rsf	61	11	protein	protein	NN
cord-269011-230p8rsf	61	12	,	,	,
cord-269011-230p8rsf	61	13	the	the	DT
cord-269011-230p8rsf	61	14	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	61	15	-	-	HYPH
cord-269011-230p8rsf	61	16	esterase	esterase	NN
cord-269011-230p8rsf	61	17	(	(	-LRB-
cord-269011-230p8rsf	61	18	HE	he	NN
cord-269011-230p8rsf	61	19	)	)	-RRB-
cord-269011-230p8rsf	61	20	protein	protein	NN
cord-269011-230p8rsf	61	21	.	.	.
cord-269011-230p8rsf	62	1	As	as	IN
cord-269011-230p8rsf	62	2	a	a	DT
cord-269011-230p8rsf	62	3	consequence	consequence	NN
cord-269011-230p8rsf	62	4	these	these	DT
cord-269011-230p8rsf	62	5	viruses	virus	NNS
cord-269011-230p8rsf	62	6	display	display	VBP
cord-269011-230p8rsf	62	7	a	a	DT
cord-269011-230p8rsf	62	8	second	second	JJ
cord-269011-230p8rsf	62	9	,	,	,
cord-269011-230p8rsf	62	10	shorter	short	JJR
cord-269011-230p8rsf	62	11	(	(	-LRB-
cord-269011-230p8rsf	62	12	5	5	CD
cord-269011-230p8rsf	62	13	nm	nm	NN
cord-269011-230p8rsf	62	14	)	)	-RRB-
cord-269011-230p8rsf	62	15	fringe	fringe	NN
cord-269011-230p8rsf	62	16	of	of	IN
cord-269011-230p8rsf	62	17	surface	surface	NN
cord-269011-230p8rsf	62	18	projections	projection	NNS
cord-269011-230p8rsf	62	19	in	in	IN
cord-269011-230p8rsf	62	20	addition	addition	NN
cord-269011-230p8rsf	62	21	to	to	IN
cord-269011-230p8rsf	62	22	the	the	DT
cord-269011-230p8rsf	62	23	spikes	spike	NNS
cord-269011-230p8rsf	62	24	(	(	-LRB-
cord-269011-230p8rsf	62	25	Fig	fig	NN
cord-269011-230p8rsf	62	26	.	.	.
cord-269011-230p8rsf	62	27	1B	1b	LS
cord-269011-230p8rsf	62	28	)	)	-RRB-
cord-269011-230p8rsf	63	1	(	(	-LRB-
cord-269011-230p8rsf	63	2	Bridger	Bridger	NNP
cord-269011-230p8rsf	63	3	et	et	NNP
cord-269011-230p8rsf	63	4	al	al	NNP
cord-269011-230p8rsf	63	5	.	.	NNP
cord-269011-230p8rsf	63	6	,	,	,
cord-269011-230p8rsf	63	7	1978	1978	CD
cord-269011-230p8rsf	64	1	;	;	:
cord-269011-230p8rsf	64	2	King	King	NNP
cord-269011-230p8rsf	64	3	et	et	NNP
cord-269011-230p8rsf	64	4	al	al	NNP
cord-269011-230p8rsf	64	5	.	.	.
cord-269011-230p8rsf	65	1	,	,	,
cord-269011-230p8rsf	65	2	1985	1985	CD
cord-269011-230p8rsf	65	3	;	;	:
cord-269011-230p8rsf	65	4	Sugiyama	Sugiyama	NNP
cord-269011-230p8rsf	65	5	and	and	CC
cord-269011-230p8rsf	65	6	Amano	Amano	NNP
cord-269011-230p8rsf	65	7	,	,	,
cord-269011-230p8rsf	65	8	1981	1981	CD
cord-269011-230p8rsf	65	9	)	)	-RRB-
cord-269011-230p8rsf	65	10	.	.	.
cord-269011-230p8rsf	66	1	The	the	DT
cord-269011-230p8rsf	66	2	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	66	3	(	(	-LRB-
cord-269011-230p8rsf	66	4	RNP	RNP	NNP
cord-269011-230p8rsf	66	5	)	)	-RRB-
cord-269011-230p8rsf	66	6	core	core	NN
cord-269011-230p8rsf	66	7	contains	contain	VBZ
cord-269011-230p8rsf	66	8	one	one	CD
cord-269011-230p8rsf	66	9	copy	copy	NN
cord-269011-230p8rsf	66	10	of	of	IN
cord-269011-230p8rsf	66	11	the	the	DT
cord-269011-230p8rsf	66	12	viral	viral	JJ
cord-269011-230p8rsf	66	13	genomic	genomic	JJ
cord-269011-230p8rsf	66	14	RNA	RNA	NNP
cord-269011-230p8rsf	66	15	.	.	.
cord-269011-230p8rsf	67	1	This	this	DT
cord-269011-230p8rsf	67	2	RNA	RNA	NNP
cord-269011-230p8rsf	67	3	is	be	VBZ
cord-269011-230p8rsf	67	4	packaged	package	VBN
cord-269011-230p8rsf	67	5	into	into	IN
cord-269011-230p8rsf	67	6	a	a	DT
cord-269011-230p8rsf	67	7	helical	helical	JJ
cord-269011-230p8rsf	67	8	structure	structure	NN
cord-269011-230p8rsf	67	9	by	by	IN
cord-269011-230p8rsf	67	10	multiple	multiple	JJ
cord-269011-230p8rsf	67	11	copies	copy	NNS
cord-269011-230p8rsf	67	12	of	of	IN
cord-269011-230p8rsf	67	13	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	67	14	protein	protein	NNP
cord-269011-230p8rsf	67	15	(	(	-LRB-
cord-269011-230p8rsf	67	16	N	N	NNP
cord-269011-230p8rsf	67	17	)	)	-RRB-
cord-269011-230p8rsf	67	18	.	.	.
cord-269011-230p8rsf	68	1	Size	size	NN
cord-269011-230p8rsf	68	2	estimations	estimation	NNS
cord-269011-230p8rsf	68	3	of	of	IN
cord-269011-230p8rsf	68	4	the	the	DT
cord-269011-230p8rsf	68	5	flexible	flexible	JJ
cord-269011-230p8rsf	68	6	cylindrical	cylindrical	JJ
cord-269011-230p8rsf	68	7	structures	structure	NNS
cord-269011-230p8rsf	68	8	varied	vary	VBN
cord-269011-230p8rsf	68	9	quite	quite	RB
cord-269011-230p8rsf	68	10	considerably	considerably	RB
cord-269011-230p8rsf	68	11	,	,	,
cord-269011-230p8rsf	68	12	ranging	range	VBG
cord-269011-230p8rsf	68	13	between	between	IN
cord-269011-230p8rsf	68	14	7	7	CD
cord-269011-230p8rsf	68	15	and	and	CC
cord-269011-230p8rsf	68	16	16	16	CD
cord-269011-230p8rsf	68	17	nm	nm	NN
cord-269011-230p8rsf	68	18	in	in	IN
cord-269011-230p8rsf	68	19	diameter	diameter	NN
cord-269011-230p8rsf	68	20	and	and	CC
cord-269011-230p8rsf	68	21	up	up	IN
cord-269011-230p8rsf	68	22	to	to	TO
cord-269011-230p8rsf	68	23	0.32	0.32	CD
cord-269011-230p8rsf	68	24	mm	mm	NNS
cord-269011-230p8rsf	68	25	in	in	IN
cord-269011-230p8rsf	68	26	length	length	NN
cord-269011-230p8rsf	69	1	(	(	-LRB-
cord-269011-230p8rsf	69	2	see	see	VB
cord-269011-230p8rsf	69	3	Laude	Laude	NNP
cord-269011-230p8rsf	69	4	and	and	CC
cord-269011-230p8rsf	69	5	Masters	Masters	NNPS
cord-269011-230p8rsf	69	6	,	,	,
cord-269011-230p8rsf	69	7	1995	1995	CD
cord-269011-230p8rsf	69	8	)	)	-RRB-
cord-269011-230p8rsf	69	9	.	.	.
cord-269011-230p8rsf	70	1	The	the	DT
cord-269011-230p8rsf	70	2	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	70	3	helix	helix	NN
cord-269011-230p8rsf	70	4	appears	appear	VBZ
cord-269011-230p8rsf	70	5	in	in	IN
cord-269011-230p8rsf	70	6	turn	turn	NN
cord-269011-230p8rsf	70	7	to	to	TO
cord-269011-230p8rsf	70	8	be	be	VB
cord-269011-230p8rsf	70	9	contained	contain	VBN
cord-269011-230p8rsf	70	10	within	within	IN
cord-269011-230p8rsf	70	11	a	a	DT
cord-269011-230p8rsf	70	12	spherical	spherical	JJ
cord-269011-230p8rsf	70	13	,	,	,
cord-269011-230p8rsf	70	14	probably	probably	RB
cord-269011-230p8rsf	70	15	icosahedral	icosahedral	JJ
cord-269011-230p8rsf	70	16	,	,	,
cord-269011-230p8rsf	70	17	configuration	configuration	NN
cord-269011-230p8rsf	70	18	as	as	IN
cord-269011-230p8rsf	70	19	indicated	indicate	VBN
cord-269011-230p8rsf	70	20	by	by	IN
cord-269011-230p8rsf	70	21	various	various	JJ
cord-269011-230p8rsf	70	22	ultrastructural	ultrastructural	JJ
cord-269011-230p8rsf	70	23	approaches	approach	NNS
cord-269011-230p8rsf	70	24	using	use	VBG
cord-269011-230p8rsf	70	25	purified	purify	VBN
cord-269011-230p8rsf	70	26	transmissible	transmissible	JJ
cord-269011-230p8rsf	70	27	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	70	28	virus	virus	NN
cord-269011-230p8rsf	70	29	(	(	-LRB-
cord-269011-230p8rsf	70	30	TGEV	TGEV	NNP
cord-269011-230p8rsf	70	31	)	)	-RRB-
cord-269011-230p8rsf	70	32	and	and	CC
cord-269011-230p8rsf	70	33	mouse	mouse	NNP
cord-269011-230p8rsf	70	34	hepatitis	hepatitis	NN
cord-269011-230p8rsf	70	35	virus	virus	NN
cord-269011-230p8rsf	70	36	(	(	-LRB-
cord-269011-230p8rsf	70	37	MHV	mhv	NN
cord-269011-230p8rsf	70	38	)	)	-RRB-
cord-269011-230p8rsf	71	1	(	(	-LRB-
cord-269011-230p8rsf	71	2	Risco	Risco	NNP
cord-269011-230p8rsf	71	3	et	et	NNP
cord-269011-230p8rsf	71	4	al	al	NNP
cord-269011-230p8rsf	71	5	.	.	.
cord-269011-230p8rsf	72	1	,	,	,
cord-269011-230p8rsf	72	2	1996	1996	CD
cord-269011-230p8rsf	73	1	(	(	-LRB-
cord-269011-230p8rsf	73	2	Risco	Risco	NNP
cord-269011-230p8rsf	73	3	et	et	NNP
cord-269011-230p8rsf	73	4	al	al	NNP
cord-269011-230p8rsf	73	5	.	.	NNP
cord-269011-230p8rsf	73	6	,	,	,
cord-269011-230p8rsf	73	7	,	,	,
cord-269011-230p8rsf	73	8	1998	1998	CD
cord-269011-230p8rsf	73	9	.	.	.
cord-269011-230p8rsf	74	1	The	the	DT
cord-269011-230p8rsf	74	2	molar	molar	JJ
cord-269011-230p8rsf	74	3	ratio	ratio	NN
cord-269011-230p8rsf	74	4	of	of	IN
cord-269011-230p8rsf	74	5	the	the	DT
cord-269011-230p8rsf	74	6	major	major	JJ
cord-269011-230p8rsf	74	7	structural	structural	JJ
cord-269011-230p8rsf	74	8	proteins	protein	NNS
cord-269011-230p8rsf	74	9	,	,	,
cord-269011-230p8rsf	74	10	S	s	NN
cord-269011-230p8rsf	74	11	:	:	:
cord-269011-230p8rsf	74	12	N	n	NN
cord-269011-230p8rsf	74	13	:	:	:
cord-269011-230p8rsf	74	14	M	M	NNP
cord-269011-230p8rsf	74	15	,	,	,
cord-269011-230p8rsf	74	16	has	have	VBZ
cord-269011-230p8rsf	74	17	been	be	VBN
cord-269011-230p8rsf	74	18	variously	variously	RB
cord-269011-230p8rsf	74	19	estimated	estimate	VBN
cord-269011-230p8rsf	74	20	to	to	TO
cord-269011-230p8rsf	74	21	be	be	VB
cord-269011-230p8rsf	74	22	approximately	approximately	RB
cord-269011-230p8rsf	74	23	1:8:16	1:8:16	CD
cord-269011-230p8rsf	74	24	(	(	-LRB-
cord-269011-230p8rsf	74	25	Sturman	Sturman	NNP
cord-269011-230p8rsf	74	26	et	et	NNP
cord-269011-230p8rsf	74	27	al	al	NNP
cord-269011-230p8rsf	74	28	.	.	NNP
cord-269011-230p8rsf	74	29	,	,	,
cord-269011-230p8rsf	74	30	1980	1980	CD
cord-269011-230p8rsf	74	31	)	)	-RRB-
cord-269011-230p8rsf	74	32	,	,	,
cord-269011-230p8rsf	74	33	1:6:15	1:6:15	NNP
cord-269011-230p8rsf	74	34	(	(	-LRB-
cord-269011-230p8rsf	74	35	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	74	36	,	,	,
cord-269011-230p8rsf	74	37	1983a	1983a	CD
cord-269011-230p8rsf	74	38	)	)	-RRB-
cord-269011-230p8rsf	74	39	,	,	,
cord-269011-230p8rsf	74	40	1:8:8	1:8:8	CD
cord-269011-230p8rsf	75	1	(	(	-LRB-
cord-269011-230p8rsf	75	2	Hogue	Hogue	NNP
cord-269011-230p8rsf	75	3	and	and	CC
cord-269011-230p8rsf	75	4	Brian	Brian	NNP
cord-269011-230p8rsf	75	5	,	,	,
cord-269011-230p8rsf	75	6	1986	1986	CD
cord-269011-230p8rsf	75	7	)	)	-RRB-
cord-269011-230p8rsf	75	8	,	,	,
cord-269011-230p8rsf	75	9	and	and	CC
cord-269011-230p8rsf	75	10	1:11:10	1:11:10	LS
cord-269011-230p8rsf	75	11	(	(	-LRB-
cord-269011-230p8rsf	75	12	Liu	Liu	NNP
cord-269011-230p8rsf	75	13	and	and	CC
cord-269011-230p8rsf	75	14	Inglis	Inglis	NNP
cord-269011-230p8rsf	75	15	,	,	,
cord-269011-230p8rsf	75	16	1991	1991	CD
cord-269011-230p8rsf	75	17	)	)	-RRB-
cord-269011-230p8rsf	75	18	,	,	,
cord-269011-230p8rsf	75	19	although	although	IN
cord-269011-230p8rsf	75	20	an	an	DT
cord-269011-230p8rsf	75	21	M	m	NN
cord-269011-230p8rsf	75	22	:	:	:
cord-269011-230p8rsf	75	23	N	n	CD
cord-269011-230p8rsf	75	24	molar	molar	JJ
cord-269011-230p8rsf	75	25	ratio	ratio	NN
cord-269011-230p8rsf	75	26	of	of	IN
cord-269011-230p8rsf	75	27	3	3	CD
cord-269011-230p8rsf	75	28	has	have	VBZ
cord-269011-230p8rsf	75	29	also	also	RB
cord-269011-230p8rsf	75	30	been	be	VBN
cord-269011-230p8rsf	75	31	reported	report	VBN
cord-269011-230p8rsf	76	1	(	(	-LRB-
cord-269011-230p8rsf	76	2	Escors	Escors	NNP
cord-269011-230p8rsf	76	3	et	et	NNP
cord-269011-230p8rsf	76	4	al	al	NNP
cord-269011-230p8rsf	76	5	.	.	NNP
cord-269011-230p8rsf	76	6	,	,	,
cord-269011-230p8rsf	76	7	2001a	2001a	CD
cord-269011-230p8rsf	76	8	)	)	-RRB-
cord-269011-230p8rsf	76	9	.	.	.
cord-269011-230p8rsf	77	1	The	the	DT
cord-269011-230p8rsf	77	2	S	S	NNP
cord-269011-230p8rsf	77	3	:	:	:
cord-269011-230p8rsf	77	4	HE	HE	NNP
cord-269011-230p8rsf	77	5	molar	molar	JJ
cord-269011-230p8rsf	77	6	ratio	ratio	NN
cord-269011-230p8rsf	77	7	was	be	VBD
cord-269011-230p8rsf	77	8	estimated	estimate	VBN
cord-269011-230p8rsf	77	9	to	to	TO
cord-269011-230p8rsf	77	10	be	be	VB
cord-269011-230p8rsf	77	11	4	4	CD
cord-269011-230p8rsf	78	1	(	(	-LRB-
cord-269011-230p8rsf	78	2	Hogue	Hogue	NNP
cord-269011-230p8rsf	78	3	and	and	CC
cord-269011-230p8rsf	78	4	Brian	Brian	NNP
cord-269011-230p8rsf	78	5	,	,	,
cord-269011-230p8rsf	78	6	1986	1986	CD
cord-269011-230p8rsf	78	7	)	)	-RRB-
cord-269011-230p8rsf	78	8	.	.	.
cord-269011-230p8rsf	79	1	The	the	DT
cord-269011-230p8rsf	79	2	E	e	NN
cord-269011-230p8rsf	79	3	protein	protein	NN
cord-269011-230p8rsf	79	4	is	be	VBZ
cord-269011-230p8rsf	79	5	only	only	RB
cord-269011-230p8rsf	79	6	a	a	DT
cord-269011-230p8rsf	79	7	minor	minor	JJ
cord-269011-230p8rsf	79	8	virion	virion	NN
cord-269011-230p8rsf	79	9	component	component	NN
cord-269011-230p8rsf	79	10	and	and	CC
cord-269011-230p8rsf	79	11	was	be	VBD
cord-269011-230p8rsf	79	12	calculated	calculate	VBN
cord-269011-230p8rsf	79	13	to	to	TO
cord-269011-230p8rsf	79	14	occur	occur	VB
cord-269011-230p8rsf	79	15	in	in	IN
cord-269011-230p8rsf	79	16	infectious	infectious	JJ
cord-269011-230p8rsf	79	17	bronchitis	bronchitis	NN
cord-269011-230p8rsf	79	18	virus	virus	NN
cord-269011-230p8rsf	79	19	(	(	-LRB-
cord-269011-230p8rsf	79	20	IBV	IBV	NNP
cord-269011-230p8rsf	79	21	)	)	-RRB-
cord-269011-230p8rsf	79	22	,	,	,
cord-269011-230p8rsf	79	23	TGEV	TGEV	NNP
cord-269011-230p8rsf	79	24	,	,	,
cord-269011-230p8rsf	79	25	and	and	CC
cord-269011-230p8rsf	79	26	MHV	MHV	NNP
cord-269011-230p8rsf	79	27	virions	virion	NNS
cord-269011-230p8rsf	79	28	at	at	IN
cord-269011-230p8rsf	79	29	a	a	DT
cord-269011-230p8rsf	79	30	rate	rate	NN
cord-269011-230p8rsf	79	31	of	of	IN
cord-269011-230p8rsf	79	32	approximately	approximately	RB
cord-269011-230p8rsf	79	33	100	100	CD
cord-269011-230p8rsf	79	34	,	,	,
cord-269011-230p8rsf	79	35	20	20	CD
cord-269011-230p8rsf	79	36	,	,	,
cord-269011-230p8rsf	79	37	and	and	CC
cord-269011-230p8rsf	79	38	10	10	CD
cord-269011-230p8rsf	79	39	molecules	molecule	NNS
cord-269011-230p8rsf	79	40	per	per	IN
cord-269011-230p8rsf	79	41	particle	particle	NN
cord-269011-230p8rsf	79	42	,	,	,
cord-269011-230p8rsf	79	43	respectively	respectively	RB
cord-269011-230p8rsf	79	44	(	(	-LRB-
cord-269011-230p8rsf	79	45	Godet	Godet	NNP
cord-269011-230p8rsf	79	46	et	et	NNP
cord-269011-230p8rsf	79	47	al	al	NNP
cord-269011-230p8rsf	79	48	.	.	NNP
cord-269011-230p8rsf	79	49	,	,	,
cord-269011-230p8rsf	79	50	1992	1992	CD
cord-269011-230p8rsf	79	51	;	;	:
cord-269011-230p8rsf	79	52	Liu	Liu	NNP
cord-269011-230p8rsf	79	53	and	and	CC
cord-269011-230p8rsf	79	54	Inglis	Inglis	NNP
cord-269011-230p8rsf	79	55	,	,	,
cord-269011-230p8rsf	79	56	1991	1991	CD
cord-269011-230p8rsf	79	57	;	;	:
cord-269011-230p8rsf	79	58	Vennema	Vennema	NNP
cord-269011-230p8rsf	79	59	et	et	FW
cord-269011-230p8rsf	79	60	al	al	NNP
cord-269011-230p8rsf	79	61	.	.	NNP
cord-269011-230p8rsf	79	62	,	,	,
cord-269011-230p8rsf	79	63	1996	1996	CD
cord-269011-230p8rsf	79	64	)	)	-RRB-
cord-269011-230p8rsf	79	65	.	.	.
cord-269011-230p8rsf	80	1	The	the	DT
cord-269011-230p8rsf	80	2	lipid	lipid	NN
cord-269011-230p8rsf	80	3	composition	composition	NN
cord-269011-230p8rsf	80	4	of	of	IN
cord-269011-230p8rsf	80	5	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	80	6	envelopes	envelope	NNS
cord-269011-230p8rsf	80	7	has	have	VBZ
cord-269011-230p8rsf	80	8	been	be	VBN
cord-269011-230p8rsf	80	9	studied	study	VBN
cord-269011-230p8rsf	80	10	only	only	RB
cord-269011-230p8rsf	80	11	to	to	IN
cord-269011-230p8rsf	80	12	a	a	DT
cord-269011-230p8rsf	80	13	limited	limited	JJ
cord-269011-230p8rsf	80	14	extent	extent	NN
cord-269011-230p8rsf	80	15	.	.	.
cord-269011-230p8rsf	81	1	Comparison	comparison	NN
cord-269011-230p8rsf	81	2	of	of	IN
cord-269011-230p8rsf	81	3	the	the	DT
cord-269011-230p8rsf	81	4	phospholipid	phospholipid	NN
cord-269011-230p8rsf	81	5	composition	composition	NN
cord-269011-230p8rsf	81	6	of	of	IN
cord-269011-230p8rsf	81	7	MHV	MHV	NNP
cord-269011-230p8rsf	81	8	with	with	IN
cord-269011-230p8rsf	81	9	that	that	DT
cord-269011-230p8rsf	81	10	of	of	IN
cord-269011-230p8rsf	81	11	its	-PRON-	PRP$
cord-269011-230p8rsf	81	12	host	host	NN
cord-269011-230p8rsf	81	13	cell	cell	NN
cord-269011-230p8rsf	81	14	showed	show	VBD
cord-269011-230p8rsf	81	15	increased	increase	VBN
cord-269011-230p8rsf	81	16	levels	level	NNS
cord-269011-230p8rsf	81	17	of	of	IN
cord-269011-230p8rsf	81	18	sphingomyelin	sphingomyelin	NN
cord-269011-230p8rsf	81	19	,	,	,
cord-269011-230p8rsf	81	20	phosphatidylserine	phosphatidylserine	NN
cord-269011-230p8rsf	81	21	,	,	,
cord-269011-230p8rsf	81	22	and	and	CC
cord-269011-230p8rsf	81	23	phosphatidylinositol	phosphatidylinositol	NN
cord-269011-230p8rsf	81	24	and	and	CC
cord-269011-230p8rsf	81	25	a	a	DT
cord-269011-230p8rsf	81	26	decrease	decrease	NN
cord-269011-230p8rsf	81	27	in	in	IN
cord-269011-230p8rsf	81	28	the	the	DT
cord-269011-230p8rsf	81	29	level	level	NN
cord-269011-230p8rsf	81	30	of	of	IN
cord-269011-230p8rsf	81	31	phosphatidylethanolamine	phosphatidylethanolamine	NN
cord-269011-230p8rsf	81	32	(	(	-LRB-
cord-269011-230p8rsf	81	33	van	van	NNP
cord-269011-230p8rsf	81	34	Genderen	Genderen	NNP
cord-269011-230p8rsf	81	35	et	et	NNP
cord-269011-230p8rsf	81	36	al	al	NNP
cord-269011-230p8rsf	81	37	.	.	NNP
cord-269011-230p8rsf	81	38	,	,	,
cord-269011-230p8rsf	81	39	1995	1995	CD
cord-269011-230p8rsf	81	40	)	)	-RRB-
cord-269011-230p8rsf	81	41	.	.	.
cord-269011-230p8rsf	82	1	Whether	whether	IN
cord-269011-230p8rsf	82	2	the	the	DT
cord-269011-230p8rsf	82	3	lipid	lipid	NN
cord-269011-230p8rsf	82	4	composition	composition	NN
cord-269011-230p8rsf	82	5	of	of	IN
cord-269011-230p8rsf	82	6	MHV	MHV	NNP
cord-269011-230p8rsf	82	7	is	be	VBZ
cord-269011-230p8rsf	82	8	an	an	DT
cord-269011-230p8rsf	82	9	accurate	accurate	JJ
cord-269011-230p8rsf	82	10	reflection	reflection	NN
cord-269011-230p8rsf	82	11	of	of	IN
cord-269011-230p8rsf	82	12	its	-PRON-	PRP$
cord-269011-230p8rsf	82	13	budding	bud	VBG
cord-269011-230p8rsf	82	14	compartment	compartment	NN
cord-269011-230p8rsf	82	15	or	or	CC
cord-269011-230p8rsf	82	16	whether	whether	IN
cord-269011-230p8rsf	82	17	certain	certain	JJ
cord-269011-230p8rsf	82	18	lipids	lipid	NNS
cord-269011-230p8rsf	82	19	become	become	VBP
cord-269011-230p8rsf	82	20	enriched	enrich	VBN
cord-269011-230p8rsf	82	21	in	in	IN
cord-269011-230p8rsf	82	22	the	the	DT
cord-269011-230p8rsf	82	23	virus	virus	NN
cord-269011-230p8rsf	82	24	during	during	IN
cord-269011-230p8rsf	82	25	budding	budding	NN
cord-269011-230p8rsf	82	26	is	be	VBZ
cord-269011-230p8rsf	82	27	not	not	RB
cord-269011-230p8rsf	82	28	known	know	VBN
cord-269011-230p8rsf	82	29	.	.	.
cord-269011-230p8rsf	83	1	What	what	WP
cord-269011-230p8rsf	83	2	follows	follow	VBZ
cord-269011-230p8rsf	83	3	is	be	VBZ
cord-269011-230p8rsf	83	4	a	a	DT
cord-269011-230p8rsf	83	5	general	general	JJ
cord-269011-230p8rsf	83	6	description	description	NN
cord-269011-230p8rsf	83	7	of	of	IN
cord-269011-230p8rsf	83	8	the	the	DT
cord-269011-230p8rsf	83	9	individual	individual	JJ
cord-269011-230p8rsf	83	10	virion	virion	NN
cord-269011-230p8rsf	83	11	components	component	NNS
cord-269011-230p8rsf	83	12	and	and	CC
cord-269011-230p8rsf	83	13	their	-PRON-	PRP$
cord-269011-230p8rsf	83	14	properties	property	NNS
cord-269011-230p8rsf	83	15	.	.	.
cord-269011-230p8rsf	84	1	This	this	DT
cord-269011-230p8rsf	84	2	description	description	NN
cord-269011-230p8rsf	84	3	is	be	VBZ
cord-269011-230p8rsf	84	4	by	by	IN
cord-269011-230p8rsf	84	5	no	no	DT
cord-269011-230p8rsf	84	6	means	means	NN
cord-269011-230p8rsf	84	7	complete	complete	JJ
cord-269011-230p8rsf	84	8	as	as	IN
cord-269011-230p8rsf	84	9	it	-PRON-	PRP
cord-269011-230p8rsf	84	10	is	be	VBZ
cord-269011-230p8rsf	84	11	restricted	restrict	VBN
cord-269011-230p8rsf	84	12	to	to	IN
cord-269011-230p8rsf	84	13	the	the	DT
cord-269011-230p8rsf	84	14	information	information	NN
cord-269011-230p8rsf	84	15	that	that	WDT
cord-269011-230p8rsf	84	16	is	be	VBZ
cord-269011-230p8rsf	84	17	of	of	IN
cord-269011-230p8rsf	84	18	relevance	relevance	NN
cord-269011-230p8rsf	84	19	to	to	IN
cord-269011-230p8rsf	84	20	the	the	DT
cord-269011-230p8rsf	84	21	main	main	JJ
cord-269011-230p8rsf	84	22	topic	topic	NN
cord-269011-230p8rsf	84	23	of	of	IN
cord-269011-230p8rsf	84	24	this	this	DT
cord-269011-230p8rsf	84	25	review	review	NN
cord-269011-230p8rsf	84	26	.	.	.
cord-269011-230p8rsf	85	1	For	for	IN
cord-269011-230p8rsf	85	2	a	a	DT
cord-269011-230p8rsf	85	3	schematic	schematic	JJ
cord-269011-230p8rsf	85	4	representation	representation	NN
cord-269011-230p8rsf	85	5	of	of	IN
cord-269011-230p8rsf	85	6	the	the	DT
cord-269011-230p8rsf	85	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	85	8	life	life	NN
cord-269011-230p8rsf	85	9	cycle	cycle	NN
cord-269011-230p8rsf	85	10	see	see	VBP
cord-269011-230p8rsf	85	11	Fig	Fig	NNP
cord-269011-230p8rsf	85	12	.	.	.
cord-269011-230p8rsf	86	1	2	2	LS
cord-269011-230p8rsf	86	2	.	.	.
cord-269011-230p8rsf	87	1	The	the	DT
cord-269011-230p8rsf	87	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	87	3	life	life	NN
cord-269011-230p8rsf	87	4	cycle	cycle	NN
cord-269011-230p8rsf	87	5	.	.	.
cord-269011-230p8rsf	88	1	The	the	DT
cord-269011-230p8rsf	88	2	replication	replication	NN
cord-269011-230p8rsf	88	3	cycle	cycle	NN
cord-269011-230p8rsf	88	4	starts	start	VBZ
cord-269011-230p8rsf	88	5	with	with	IN
cord-269011-230p8rsf	88	6	attachment	attachment	NN
cord-269011-230p8rsf	88	7	of	of	IN
cord-269011-230p8rsf	88	8	the	the	DT
cord-269011-230p8rsf	88	9	virion	virion	NN
cord-269011-230p8rsf	88	10	by	by	IN
cord-269011-230p8rsf	88	11	its	-PRON-	PRP$
cord-269011-230p8rsf	88	12	S	S	NNP
cord-269011-230p8rsf	88	13	protein	protein	NN
cord-269011-230p8rsf	88	14	,	,	,
cord-269011-230p8rsf	88	15	that	that	RB
cord-269011-230p8rsf	88	16	is	is	RB
cord-269011-230p8rsf	88	17	,	,	,
cord-269011-230p8rsf	88	18	through	through	IN
cord-269011-230p8rsf	88	19	the	the	DT
cord-269011-230p8rsf	88	20	S1	s1	NN
cord-269011-230p8rsf	88	21	subunit	subunit	NN
cord-269011-230p8rsf	88	22	thereof	thereof	RB
cord-269011-230p8rsf	88	23	,	,	,
cord-269011-230p8rsf	88	24	to	to	IN
cord-269011-230p8rsf	88	25	the	the	DT
cord-269011-230p8rsf	88	26	receptors	receptor	NNS
cord-269011-230p8rsf	88	27	on	on	IN
cord-269011-230p8rsf	88	28	the	the	DT
cord-269011-230p8rsf	88	29	host	host	NN
cord-269011-230p8rsf	88	30	cell	cell	NN
cord-269011-230p8rsf	88	31	.	.	.
cord-269011-230p8rsf	89	1	This	this	DT
cord-269011-230p8rsf	89	2	interaction	interaction	NN
cord-269011-230p8rsf	89	3	leads	lead	VBZ
cord-269011-230p8rsf	89	4	to	to	IN
cord-269011-230p8rsf	89	5	fusion	fusion	NN
cord-269011-230p8rsf	89	6	of	of	IN
cord-269011-230p8rsf	89	7	the	the	DT
cord-269011-230p8rsf	89	8	virus	virus	NN
cord-269011-230p8rsf	89	9	envelope	envelope	NN
cord-269011-230p8rsf	89	10	with	with	IN
cord-269011-230p8rsf	89	11	a	a	DT
cord-269011-230p8rsf	89	12	cellular	cellular	JJ
cord-269011-230p8rsf	89	13	membrane	membrane	NN
cord-269011-230p8rsf	89	14	,	,	,
cord-269011-230p8rsf	89	15	Coronaviruses	Coronaviruses	NNP
cord-269011-230p8rsf	89	16	contain	contain	VBP
cord-269011-230p8rsf	89	17	a	a	DT
cord-269011-230p8rsf	89	18	single	single	RB
cord-269011-230p8rsf	89	19	-	-	HYPH
cord-269011-230p8rsf	89	20	stranded	strand	VBN
cord-269011-230p8rsf	89	21	positive	positive	JJ
cord-269011-230p8rsf	89	22	-	-	HYPH
cord-269011-230p8rsf	89	23	sense	sense	NN
cord-269011-230p8rsf	89	24	RNA	RNA	NNP
cord-269011-230p8rsf	89	25	genome	genome	NN
cord-269011-230p8rsf	89	26	of	of	IN
cord-269011-230p8rsf	89	27	some	some	DT
cord-269011-230p8rsf	89	28	27	27	CD
cord-269011-230p8rsf	89	29	to	to	TO
cord-269011-230p8rsf	89	30	31	31	CD
cord-269011-230p8rsf	89	31	kilobases	kilobase	NNS
cord-269011-230p8rsf	89	32	,	,	,
cord-269011-230p8rsf	89	33	the	the	DT
cord-269011-230p8rsf	89	34	largest	large	JJS
cord-269011-230p8rsf	89	35	nonsegmented	nonsegmente	VBN
cord-269011-230p8rsf	89	36	viral	viral	JJ
cord-269011-230p8rsf	89	37	RNA	RNA	NNP
cord-269011-230p8rsf	89	38	genomes	genome	NNS
cord-269011-230p8rsf	89	39	known	know	VBN
cord-269011-230p8rsf	89	40	.	.	.
cord-269011-230p8rsf	90	1	The	the	DT
cord-269011-230p8rsf	90	2	RNA	RNA	NNP
cord-269011-230p8rsf	90	3	has	have	VBZ
cord-269011-230p8rsf	90	4	a	a	DT
cord-269011-230p8rsf	90	5	5	5	CD
cord-269011-230p8rsf	90	6	0	0	CD
cord-269011-230p8rsf	90	7	-terminal	-terminal	JJ
cord-269011-230p8rsf	90	8	cap	cap	NN
cord-269011-230p8rsf	90	9	and	and	CC
cord-269011-230p8rsf	90	10	a	a	DT
cord-269011-230p8rsf	90	11	3	3	CD
cord-269011-230p8rsf	90	12	0terminal	0terminal	CD
cord-269011-230p8rsf	90	13	poly(A	poly(A	NNP
cord-269011-230p8rsf	90	14	)	)	-RRB-
cord-269011-230p8rsf	90	15	tract	tract	NN
cord-269011-230p8rsf	90	16	.	.	.
cord-269011-230p8rsf	91	1	Both	both	DT
cord-269011-230p8rsf	91	2	genomic	genomic	JJ
cord-269011-230p8rsf	91	3	termini	terminus	NNS
cord-269011-230p8rsf	91	4	contain	contain	VBP
cord-269011-230p8rsf	91	5	untranslated	untranslated	JJ
cord-269011-230p8rsf	91	6	regions	region	NNS
cord-269011-230p8rsf	91	7	(	(	-LRB-
cord-269011-230p8rsf	91	8	UTRs	UTRs	NNP
cord-269011-230p8rsf	91	9	)	)	-RRB-
cord-269011-230p8rsf	91	10	of	of	IN
cord-269011-230p8rsf	91	11	some	some	DT
cord-269011-230p8rsf	91	12	200	200	CD
cord-269011-230p8rsf	91	13	-	-	SYM
cord-269011-230p8rsf	91	14	500	500	CD
cord-269011-230p8rsf	91	15	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	91	16	that	that	WDT
cord-269011-230p8rsf	91	17	harbor	harbor	VBP
cord-269011-230p8rsf	91	18	several	several	JJ
cord-269011-230p8rsf	91	19	cis	cis	NNP
cord-269011-230p8rsf	91	20	-	-	HYPH
cord-269011-230p8rsf	91	21	acting	act	VBG
cord-269011-230p8rsf	91	22	sequences	sequence	NNS
cord-269011-230p8rsf	91	23	and	and	CC
cord-269011-230p8rsf	91	24	structural	structural	JJ
cord-269011-230p8rsf	91	25	elements	element	NNS
cord-269011-230p8rsf	91	26	functioning	function	VBG
cord-269011-230p8rsf	91	27	in	in	IN
cord-269011-230p8rsf	91	28	viral	viral	JJ
cord-269011-230p8rsf	91	29	replication	replication	NN
cord-269011-230p8rsf	91	30	and	and	CC
cord-269011-230p8rsf	91	31	transcription	transcription	NN
cord-269011-230p8rsf	91	32	.	.	.
cord-269011-230p8rsf	92	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	92	2	have	have	VBP
cord-269011-230p8rsf	92	3	a	a	DT
cord-269011-230p8rsf	92	4	typical	typical	JJ
cord-269011-230p8rsf	92	5	genome	genome	NN
cord-269011-230p8rsf	92	6	organization	organization	NN
cord-269011-230p8rsf	92	7	characterized	characterize	VBN
cord-269011-230p8rsf	92	8	by	by	IN
cord-269011-230p8rsf	92	9	the	the	DT
cord-269011-230p8rsf	92	10	occurrence	occurrence	NN
cord-269011-230p8rsf	92	11	of	of	IN
cord-269011-230p8rsf	92	12	a	a	DT
cord-269011-230p8rsf	92	13	distinctive	distinctive	JJ
cord-269011-230p8rsf	92	14	set	set	NN
cord-269011-230p8rsf	92	15	of	of	IN
cord-269011-230p8rsf	92	16	genes	gene	NNS
cord-269011-230p8rsf	92	17	that	that	WDT
cord-269011-230p8rsf	92	18	are	be	VBP
cord-269011-230p8rsf	92	19	essential	essential	JJ
cord-269011-230p8rsf	92	20	for	for	IN
cord-269011-230p8rsf	92	21	viability	viability	NN
cord-269011-230p8rsf	92	22	and	and	CC
cord-269011-230p8rsf	92	23	occur	occur	VBP
cord-269011-230p8rsf	92	24	in	in	IN
cord-269011-230p8rsf	92	25	a	a	DT
cord-269011-230p8rsf	92	26	fixed	fixed	JJ
cord-269011-230p8rsf	92	27	order	order	NN
cord-269011-230p8rsf	92	28	:	:	:
cord-269011-230p8rsf	92	29	5	5	CD
cord-269011-230p8rsf	92	30	0	0	CD
cord-269011-230p8rsf	93	1	-polymerase	-polymerase	NFP
cord-269011-230p8rsf	94	1	(	(	-LRB-
cord-269011-230p8rsf	94	2	pol)-S	pol)-s	JJ
cord-269011-230p8rsf	94	3	-	-	HYPH
cord-269011-230p8rsf	94	4	E	E	NNP
cord-269011-230p8rsf	94	5	-	-	HYPH
cord-269011-230p8rsf	94	6	M	M	NNP
cord-269011-230p8rsf	94	7	-	-	HYPH
cord-269011-230p8rsf	94	8	N-3	N-3	NNP
cord-269011-230p8rsf	94	9	0	0	CD
cord-269011-230p8rsf	95	1	(	(	-LRB-
cord-269011-230p8rsf	95	2	Fig	Fig	NNP
cord-269011-230p8rsf	95	3	.	.	.
cord-269011-230p8rsf	95	4	3	3	CD
cord-269011-230p8rsf	95	5	)	)	-RRB-
cord-269011-230p8rsf	95	6	.	.	.
cord-269011-230p8rsf	96	1	The	the	DT
cord-269011-230p8rsf	96	2	pol	pol	NN
cord-269011-230p8rsf	96	3	gene	gene	NN
cord-269011-230p8rsf	96	4	comprises	comprise	VBZ
cord-269011-230p8rsf	96	5	approximately	approximately	RB
cord-269011-230p8rsf	96	6	twothirds	twothird	NNS
cord-269011-230p8rsf	96	7	of	of	IN
cord-269011-230p8rsf	96	8	the	the	DT
cord-269011-230p8rsf	96	9	genome	genome	NN
cord-269011-230p8rsf	96	10	,	,	,
cord-269011-230p8rsf	96	11	from	from	IN
cord-269011-230p8rsf	96	12	which	which	WDT
cord-269011-230p8rsf	96	13	it	-PRON-	PRP
cord-269011-230p8rsf	96	14	is	be	VBZ
cord-269011-230p8rsf	96	15	translated	translate	VBN
cord-269011-230p8rsf	96	16	directly	directly	RB
cord-269011-230p8rsf	96	17	.	.	.
cord-269011-230p8rsf	97	1	It	-PRON-	PRP
cord-269011-230p8rsf	97	2	encodes	encode	VBZ
cord-269011-230p8rsf	97	3	two	two	CD
cord-269011-230p8rsf	97	4	large	large	JJ
cord-269011-230p8rsf	97	5	precursors	precursor	NNS
cord-269011-230p8rsf	97	6	(	(	-LRB-
cord-269011-230p8rsf	97	7	Pol1a	Pol1a	NNP
cord-269011-230p8rsf	97	8	and	and	CC
cord-269011-230p8rsf	97	9	Pol1ab	Pol1ab	NNP
cord-269011-230p8rsf	97	10	)	)	-RRB-
cord-269011-230p8rsf	97	11	,	,	,
cord-269011-230p8rsf	97	12	the	the	DT
cord-269011-230p8rsf	97	13	many	many	JJ
cord-269011-230p8rsf	97	14	functional	functional	JJ
cord-269011-230p8rsf	97	15	cleavage	cleavage	NN
cord-269011-230p8rsf	97	16	products	product	NNS
cord-269011-230p8rsf	97	17	of	of	IN
cord-269011-230p8rsf	97	18	which	which	WDT
cord-269011-230p8rsf	97	19	are	be	VBP
cord-269011-230p8rsf	97	20	collectively	collectively	RB
cord-269011-230p8rsf	97	21	responsible	responsible	JJ
cord-269011-230p8rsf	97	22	for	for	IN
cord-269011-230p8rsf	97	23	RNA	RNA	NNP
cord-269011-230p8rsf	97	24	replication	replication	NN
cord-269011-230p8rsf	97	25	and	and	CC
cord-269011-230p8rsf	97	26	transcription	transcription	NN
cord-269011-230p8rsf	97	27	(	(	-LRB-
cord-269011-230p8rsf	97	28	for	for	IN
cord-269011-230p8rsf	97	29	reviews	review	NNS
cord-269011-230p8rsf	97	30	on	on	IN
cord-269011-230p8rsf	97	31	coronavirus	coronavirus	NN
cord-269011-230p8rsf	97	32	transcription	transcription	NN
cord-269011-230p8rsf	97	33	and	and	CC
cord-269011-230p8rsf	97	34	replication	replication	NN
cord-269011-230p8rsf	97	35	see	see	VBP
cord-269011-230p8rsf	97	36	de	de	NNP
cord-269011-230p8rsf	97	37	Vries	Vries	NNP
cord-269011-230p8rsf	97	38	et	et	NNP
cord-269011-230p8rsf	97	39	al	al	NNP
cord-269011-230p8rsf	97	40	.	.	.
cord-269011-230p8rsf	98	1	,	,	,
cord-269011-230p8rsf	98	2	1997	1997	CD
cord-269011-230p8rsf	98	3	;	;	:
cord-269011-230p8rsf	98	4	Lai	Lai	NNP
cord-269011-230p8rsf	98	5	,	,	,
cord-269011-230p8rsf	98	6	1997	1997	CD
cord-269011-230p8rsf	98	7	;	;	:
cord-269011-230p8rsf	98	8	Lai	Lai	NNP
cord-269011-230p8rsf	98	9	and	and	CC
cord-269011-230p8rsf	98	10	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	98	11	,	,	,
cord-269011-230p8rsf	98	12	1997	1997	CD
cord-269011-230p8rsf	98	13	;	;	:
cord-269011-230p8rsf	98	14	Lai	Lai	NNP
cord-269011-230p8rsf	98	15	et	et	FW
cord-269011-230p8rsf	98	16	al	al	NNP
cord-269011-230p8rsf	98	17	.	.	NNP
cord-269011-230p8rsf	98	18	,	,	,
cord-269011-230p8rsf	98	19	1994	1994	CD
cord-269011-230p8rsf	98	20	;	;	:
cord-269011-230p8rsf	98	21	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	98	22	and	and	CC
cord-269011-230p8rsf	98	23	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	98	24	,	,	,
cord-269011-230p8rsf	98	25	1998	1998	CD
cord-269011-230p8rsf	98	26	;	;	:
cord-269011-230p8rsf	98	27	Ziebuhr	Ziebuhr	NNP
cord-269011-230p8rsf	98	28	et	et	NNP
cord-269011-230p8rsf	98	29	al	al	NNP
cord-269011-230p8rsf	98	30	.	.	NNP
cord-269011-230p8rsf	98	31	,	,	,
cord-269011-230p8rsf	98	32	2000	2000	CD
cord-269011-230p8rsf	98	33	)	)	-RRB-
cord-269011-230p8rsf	98	34	.	.	.
cord-269011-230p8rsf	99	1	The	the	DT
cord-269011-230p8rsf	99	2	more	more	RBR
cord-269011-230p8rsf	99	3	downstream	downstream	JJ
cord-269011-230p8rsf	99	4	pol1b	pol1b	JJ
cord-269011-230p8rsf	99	5	gene	gene	NN
cord-269011-230p8rsf	99	6	is	be	VBZ
cord-269011-230p8rsf	99	7	translated	translate	VBN
cord-269011-230p8rsf	99	8	by	by	IN
cord-269011-230p8rsf	99	9	translational	translational	JJ
cord-269011-230p8rsf	99	10	readthrough	readthrough	NN
cord-269011-230p8rsf	99	11	,	,	,
cord-269011-230p8rsf	99	12	for	for	IN
cord-269011-230p8rsf	99	13	which	which	WDT
cord-269011-230p8rsf	99	14	the	the	DT
cord-269011-230p8rsf	99	15	S2	S2	NNP
cord-269011-230p8rsf	99	16	subunit	subunit	NN
cord-269011-230p8rsf	99	17	is	be	VBZ
cord-269011-230p8rsf	99	18	responsible	responsible	JJ
cord-269011-230p8rsf	99	19	.	.	.
cord-269011-230p8rsf	100	1	From	from	IN
cord-269011-230p8rsf	100	2	the	the	DT
cord-269011-230p8rsf	100	3	genomic	genomic	JJ
cord-269011-230p8rsf	100	4	RNA	rna	NN
cord-269011-230p8rsf	100	5	that	that	WDT
cord-269011-230p8rsf	100	6	is	be	VBZ
cord-269011-230p8rsf	100	7	released	release	VBN
cord-269011-230p8rsf	100	8	by	by	IN
cord-269011-230p8rsf	100	9	disassembly	disassembly	NN
cord-269011-230p8rsf	100	10	of	of	IN
cord-269011-230p8rsf	100	11	the	the	DT
cord-269011-230p8rsf	100	12	incoming	incoming	JJ
cord-269011-230p8rsf	100	13	particle	particle	NN
cord-269011-230p8rsf	101	1	the	the	DT
cord-269011-230p8rsf	101	2	pol1a	pol1a	VBN
cord-269011-230p8rsf	101	3	and	and	CC
cord-269011-230p8rsf	101	4	pol1b	pol1b	NNP
cord-269011-230p8rsf	101	5	genes	gene	NNS
cord-269011-230p8rsf	101	6	are	be	VBP
cord-269011-230p8rsf	101	7	translated	translate	VBN
cord-269011-230p8rsf	101	8	,	,	,
cord-269011-230p8rsf	101	9	resulting	result	VBG
cord-269011-230p8rsf	101	10	in	in	IN
cord-269011-230p8rsf	101	11	the	the	DT
cord-269011-230p8rsf	101	12	production	production	NN
cord-269011-230p8rsf	101	13	of	of	IN
cord-269011-230p8rsf	101	14	two	two	CD
cord-269011-230p8rsf	101	15	large	large	JJ
cord-269011-230p8rsf	101	16	precursors	precursor	NNS
cord-269011-230p8rsf	101	17	(	(	-LRB-
cord-269011-230p8rsf	101	18	Pol1a	Pol1a	NNP
cord-269011-230p8rsf	101	19	and	and	CC
cord-269011-230p8rsf	101	20	Pol1ab	Pol1ab	NNP
cord-269011-230p8rsf	101	21	)	)	-RRB-
cord-269011-230p8rsf	102	1	,	,	,
cord-269011-230p8rsf	102	2	the	the	DT
cord-269011-230p8rsf	102	3	many	many	JJ
cord-269011-230p8rsf	102	4	cleavage	cleavage	NN
cord-269011-230p8rsf	102	5	products	product	NNS
cord-269011-230p8rsf	102	6	of	of	IN
cord-269011-230p8rsf	102	7	which	which	WDT
cord-269011-230p8rsf	102	8	collectively	collectively	RB
cord-269011-230p8rsf	102	9	constitute	constitute	VBP
cord-269011-230p8rsf	102	10	the	the	DT
cord-269011-230p8rsf	102	11	functional	functional	JJ
cord-269011-230p8rsf	102	12	replication	replication	NN
cord-269011-230p8rsf	102	13	-	-	HYPH
cord-269011-230p8rsf	102	14	transcription	transcription	NN
cord-269011-230p8rsf	102	15	complex	complex	NN
cord-269011-230p8rsf	102	16	.	.	.
cord-269011-230p8rsf	103	1	Genes	gene	NNS
cord-269011-230p8rsf	103	2	located	locate	VBN
cord-269011-230p8rsf	103	3	downstream	downstream	RB
cord-269011-230p8rsf	103	4	of	of	IN
cord-269011-230p8rsf	103	5	the	the	DT
cord-269011-230p8rsf	103	6	pol1b	pol1b	NNP
cord-269011-230p8rsf	103	7	gene	gene	NN
cord-269011-230p8rsf	103	8	are	be	VBP
cord-269011-230p8rsf	103	9	expressed	express	VBN
cord-269011-230p8rsf	103	10	from	from	IN
cord-269011-230p8rsf	103	11	a	a	DT
cord-269011-230p8rsf	103	12	3	3	CD
cord-269011-230p8rsf	103	13	0	0	CD
cord-269011-230p8rsf	103	14	-coterminal	-coterminal	JJ
cord-269011-230p8rsf	103	15	nested	nested	JJ
cord-269011-230p8rsf	103	16	set	set	NN
cord-269011-230p8rsf	103	17	of	of	IN
cord-269011-230p8rsf	103	18	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	103	19	(	(	-LRB-
cord-269011-230p8rsf	103	20	sg	sg	NNP
cord-269011-230p8rsf	103	21	)	)	-RRB-
cord-269011-230p8rsf	103	22	mRNAs	mRNAs	NNP
cord-269011-230p8rsf	103	23	,	,	,
cord-269011-230p8rsf	103	24	each	each	DT
cord-269011-230p8rsf	103	25	of	of	IN
cord-269011-230p8rsf	103	26	which	which	WDT
cord-269011-230p8rsf	103	27	additionally	additionally	RB
cord-269011-230p8rsf	103	28	contains	contain	VBZ
cord-269011-230p8rsf	103	29	a	a	DT
cord-269011-230p8rsf	103	30	short	short	JJ
cord-269011-230p8rsf	103	31	5	5	CD
cord-269011-230p8rsf	103	32	0	0	CD
cord-269011-230p8rsf	103	33	leader	leader	NN
cord-269011-230p8rsf	103	34	sequence	sequence	NN
cord-269011-230p8rsf	103	35	derived	derive	VBN
cord-269011-230p8rsf	103	36	from	from	IN
cord-269011-230p8rsf	103	37	the	the	DT
cord-269011-230p8rsf	103	38	5	5	CD
cord-269011-230p8rsf	103	39	0	0	CD
cord-269011-230p8rsf	103	40	end	end	NN
cord-269011-230p8rsf	103	41	of	of	IN
cord-269011-230p8rsf	103	42	the	the	DT
cord-269011-230p8rsf	103	43	genome	genome	NN
cord-269011-230p8rsf	103	44	(	(	-LRB-
cord-269011-230p8rsf	103	45	shown	show	VBN
cord-269011-230p8rsf	103	46	in	in	IN
cord-269011-230p8rsf	103	47	red	red	JJ
cord-269011-230p8rsf	103	48	)	)	-RRB-
cord-269011-230p8rsf	103	49	.	.	.
cord-269011-230p8rsf	104	1	Transcription	transcription	NN
cord-269011-230p8rsf	104	2	regulatory	regulatory	JJ
cord-269011-230p8rsf	104	3	sequences	sequence	NNS
cord-269011-230p8rsf	104	4	(	(	-LRB-
cord-269011-230p8rsf	104	5	TRSs	TRSs	NNP
cord-269011-230p8rsf	104	6	)	)	-RRB-
cord-269011-230p8rsf	104	7	located	locate	VBN
cord-269011-230p8rsf	104	8	upstream	upstream	RB
cord-269011-230p8rsf	104	9	of	of	IN
cord-269011-230p8rsf	104	10	each	each	DT
cord-269011-230p8rsf	104	11	gene	gene	NN
cord-269011-230p8rsf	104	12	serve	serve	VBP
cord-269011-230p8rsf	104	13	as	as	IN
cord-269011-230p8rsf	104	14	signals	signal	NNS
cord-269011-230p8rsf	104	15	for	for	IN
cord-269011-230p8rsf	104	16	the	the	DT
cord-269011-230p8rsf	104	17	transcription	transcription	NN
cord-269011-230p8rsf	104	18	of	of	IN
cord-269011-230p8rsf	104	19	the	the	DT
cord-269011-230p8rsf	104	20	sgRNAs	sgrna	NNS
cord-269011-230p8rsf	104	21	.	.	.
cord-269011-230p8rsf	105	1	The	the	DT
cord-269011-230p8rsf	105	2	leader	leader	NN
cord-269011-230p8rsf	105	3	sequence	sequence	NN
cord-269011-230p8rsf	105	4	is	be	VBZ
cord-269011-230p8rsf	105	5	joined	join	VBN
cord-269011-230p8rsf	105	6	at	at	IN
cord-269011-230p8rsf	105	7	a	a	DT
cord-269011-230p8rsf	105	8	TRS	TRS	NNP
cord-269011-230p8rsf	105	9	to	to	IN
cord-269011-230p8rsf	105	10	all	all	DT
cord-269011-230p8rsf	105	11	genomic	genomic	JJ
cord-269011-230p8rsf	105	12	sequence	sequence	NN
cord-269011-230p8rsf	105	13	distal	distal	JJ
cord-269011-230p8rsf	105	14	to	to	IN
cord-269011-230p8rsf	105	15	that	that	DT
cord-269011-230p8rsf	105	16	TRS	TRS	NNP
cord-269011-230p8rsf	105	17	by	by	IN
cord-269011-230p8rsf	105	18	discontinuous	discontinuous	JJ
cord-269011-230p8rsf	105	19	transcription	transcription	NN
cord-269011-230p8rsf	105	20	,	,	,
cord-269011-230p8rsf	105	21	most	most	RBS
cord-269011-230p8rsf	105	22	likely	likely	JJ
cord-269011-230p8rsf	105	23	during	during	IN
cord-269011-230p8rsf	105	24	the	the	DT
cord-269011-230p8rsf	105	25	synthesis	synthesis	NN
cord-269011-230p8rsf	105	26	of	of	IN
cord-269011-230p8rsf	105	27	negative	negative	JJ
cord-269011-230p8rsf	105	28	-	-	HYPH
cord-269011-230p8rsf	105	29	strand	strand	NN
cord-269011-230p8rsf	105	30	sgRNAs	sgrna	NNS
cord-269011-230p8rsf	105	31	.	.	.
cord-269011-230p8rsf	106	1	In	in	IN
cord-269011-230p8rsf	106	2	most	most	JJS
cord-269011-230p8rsf	106	3	cases	case	NNS
cord-269011-230p8rsf	106	4	,	,	,
cord-269011-230p8rsf	106	5	only	only	RB
cord-269011-230p8rsf	106	6	the	the	DT
cord-269011-230p8rsf	106	7	5	5	CD
cord-269011-230p8rsf	106	8	0	0	CD
cord-269011-230p8rsf	106	9	-most	-most	NN
cord-269011-230p8rsf	106	10	gene	gene	NN
cord-269011-230p8rsf	106	11	of	of	IN
cord-269011-230p8rsf	106	12	each	each	DT
cord-269011-230p8rsf	106	13	sgRNA	sgRNA	VBG
cord-269011-230p8rsf	106	14	is	be	VBZ
cord-269011-230p8rsf	106	15	translated	translate	VBN
cord-269011-230p8rsf	106	16	.	.	.
cord-269011-230p8rsf	107	1	Multiple	multiple	JJ
cord-269011-230p8rsf	107	2	copies	copy	NNS
cord-269011-230p8rsf	107	3	of	of	IN
cord-269011-230p8rsf	107	4	the	the	DT
cord-269011-230p8rsf	107	5	N	N	NNP
cord-269011-230p8rsf	107	6	protein	protein	NN
cord-269011-230p8rsf	107	7	package	package	NN
cord-269011-230p8rsf	107	8	the	the	DT
cord-269011-230p8rsf	107	9	genomic	genomic	JJ
cord-269011-230p8rsf	107	10	RNA	RNA	NNP
cord-269011-230p8rsf	107	11	into	into	IN
cord-269011-230p8rsf	107	12	a	a	DT
cord-269011-230p8rsf	107	13	helical	helical	JJ
cord-269011-230p8rsf	107	14	structure	structure	NN
cord-269011-230p8rsf	107	15	in	in	IN
cord-269011-230p8rsf	107	16	the	the	DT
cord-269011-230p8rsf	107	17	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	107	18	.	.	.
cord-269011-230p8rsf	108	1	The	the	DT
cord-269011-230p8rsf	108	2	structural	structural	JJ
cord-269011-230p8rsf	108	3	proteins	protein	NNS
cord-269011-230p8rsf	108	4	S	S	NNP
cord-269011-230p8rsf	108	5	,	,	,
cord-269011-230p8rsf	108	6	M	M	NNP
cord-269011-230p8rsf	108	7	,	,	,
cord-269011-230p8rsf	108	8	and	and	CC
cord-269011-230p8rsf	108	9	E	E	NNS
cord-269011-230p8rsf	108	10	are	be	VBP
cord-269011-230p8rsf	108	11	inserted	insert	VBN
cord-269011-230p8rsf	108	12	into	into	IN
cord-269011-230p8rsf	108	13	the	the	DT
cord-269011-230p8rsf	108	14	membrane	membrane	NN
cord-269011-230p8rsf	108	15	of	of	IN
cord-269011-230p8rsf	108	16	the	the	DT
cord-269011-230p8rsf	108	17	rough	rough	JJ
cord-269011-230p8rsf	108	18	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	108	19	reticulum	reticulum	NN
cord-269011-230p8rsf	108	20	(	(	-LRB-
cord-269011-230p8rsf	108	21	RER	RER	NNP
cord-269011-230p8rsf	108	22	)	)	-RRB-
cord-269011-230p8rsf	108	23	,	,	,
cord-269011-230p8rsf	108	24	from	from	IN
cord-269011-230p8rsf	108	25	where	where	WRB
cord-269011-230p8rsf	108	26	they	-PRON-	PRP
cord-269011-230p8rsf	108	27	are	be	VBP
cord-269011-230p8rsf	108	28	transported	transport	VBN
cord-269011-230p8rsf	108	29	to	to	IN
cord-269011-230p8rsf	108	30	the	the	DT
cord-269011-230p8rsf	108	31	ER	er	NN
cord-269011-230p8rsf	108	32	-	-	HYPH
cord-269011-230p8rsf	108	33	to	to	IN
cord-269011-230p8rsf	108	34	-	-	HYPH
cord-269011-230p8rsf	108	35	Golgi	golgi	NN
cord-269011-230p8rsf	108	36	intermediate	intermediate	JJ
cord-269011-230p8rsf	108	37	compartment	compartment	NN
cord-269011-230p8rsf	108	38	(	(	-LRB-
cord-269011-230p8rsf	108	39	ERGIC	ERGIC	NNP
cord-269011-230p8rsf	108	40	)	)	-RRB-
cord-269011-230p8rsf	108	41	to	to	TO
cord-269011-230p8rsf	108	42	meet	meet	VB
cord-269011-230p8rsf	108	43	the	the	DT
cord-269011-230p8rsf	108	44	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	108	45	and	and	CC
cord-269011-230p8rsf	108	46	assemble	assemble	VB
cord-269011-230p8rsf	108	47	into	into	IN
cord-269011-230p8rsf	108	48	particles	particle	NNS
cord-269011-230p8rsf	108	49	by	by	IN
cord-269011-230p8rsf	108	50	budding	bud	VBG
cord-269011-230p8rsf	108	51	.	.	.
cord-269011-230p8rsf	109	1	The	the	DT
cord-269011-230p8rsf	109	2	M	M	NNP
cord-269011-230p8rsf	109	3	protein	protein	NN
cord-269011-230p8rsf	109	4	plays	play	VBZ
cord-269011-230p8rsf	109	5	a	a	DT
cord-269011-230p8rsf	109	6	central	central	JJ
cord-269011-230p8rsf	109	7	role	role	NN
cord-269011-230p8rsf	109	8	in	in	IN
cord-269011-230p8rsf	109	9	this	this	DT
cord-269011-230p8rsf	109	10	process	process	NN
cord-269011-230p8rsf	109	11	through	through	IN
cord-269011-230p8rsf	109	12	interactions	interaction	NNS
cord-269011-230p8rsf	109	13	with	with	IN
cord-269011-230p8rsf	109	14	all	all	DT
cord-269011-230p8rsf	109	15	viral	viral	JJ
cord-269011-230p8rsf	109	16	assembly	assembly	NN
cord-269011-230p8rsf	109	17	partners	partner	NNS
cord-269011-230p8rsf	109	18	.	.	.
cord-269011-230p8rsf	110	1	It	-PRON-	PRP
cord-269011-230p8rsf	110	2	gives	give	VBZ
cord-269011-230p8rsf	110	3	rise	rise	NN
cord-269011-230p8rsf	110	4	to	to	IN
cord-269011-230p8rsf	110	5	the	the	DT
cord-269011-230p8rsf	110	6	formation	formation	NN
cord-269011-230p8rsf	110	7	of	of	IN
cord-269011-230p8rsf	110	8	the	the	DT
cord-269011-230p8rsf	110	9	basic	basic	JJ
cord-269011-230p8rsf	110	10	matrix	matrix	NN
cord-269011-230p8rsf	110	11	of	of	IN
cord-269011-230p8rsf	110	12	the	the	DT
cord-269011-230p8rsf	110	13	viral	viral	JJ
cord-269011-230p8rsf	110	14	envelope	envelope	NN
cord-269011-230p8rsf	110	15	generated	generate	VBN
cord-269011-230p8rsf	110	16	by	by	IN
cord-269011-230p8rsf	110	17	homotypic	homotypic	NNP
cord-269011-230p8rsf	110	18	,	,	,
cord-269011-230p8rsf	110	19	lateral	lateral	JJ
cord-269011-230p8rsf	110	20	interactions	interaction	NNS
cord-269011-230p8rsf	110	21	between	between	IN
cord-269011-230p8rsf	110	22	M	M	NNP
cord-269011-230p8rsf	110	23	molecules	molecule	NNS
cord-269011-230p8rsf	110	24	,	,	,
cord-269011-230p8rsf	110	25	and	and	CC
cord-269011-230p8rsf	110	26	it	-PRON-	PRP
cord-269011-230p8rsf	110	27	interacts	interact	VBZ
cord-269011-230p8rsf	110	28	with	with	IN
cord-269011-230p8rsf	110	29	the	the	DT
cord-269011-230p8rsf	110	30	envelope	envelope	NN
cord-269011-230p8rsf	110	31	proteins	protein	NNS
cord-269011-230p8rsf	110	32	E	E	NNP
cord-269011-230p8rsf	110	33	,	,	,
cord-269011-230p8rsf	110	34	S	S	NNP
cord-269011-230p8rsf	110	35	,	,	,
cord-269011-230p8rsf	110	36	and	and	CC
cord-269011-230p8rsf	110	37	HE	he	PRP
cord-269011-230p8rsf	110	38	(	(	-LRB-
cord-269011-230p8rsf	110	39	if	if	IN
cord-269011-230p8rsf	110	40	present	present	JJ
cord-269011-230p8rsf	110	41	)	)	-RRB-
cord-269011-230p8rsf	110	42	,	,	,
cord-269011-230p8rsf	110	43	as	as	RB
cord-269011-230p8rsf	110	44	well	well	RB
cord-269011-230p8rsf	110	45	as	as	IN
cord-269011-230p8rsf	110	46	with	with	IN
cord-269011-230p8rsf	110	47	the	the	DT
cord-269011-230p8rsf	110	48	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	110	49	,	,	,
cord-269011-230p8rsf	110	50	thereby	thereby	RB
cord-269011-230p8rsf	110	51	directing	direct	VBG
cord-269011-230p8rsf	110	52	the	the	DT
cord-269011-230p8rsf	110	53	assembly	assembly	NN
cord-269011-230p8rsf	110	54	of	of	IN
cord-269011-230p8rsf	110	55	the	the	DT
cord-269011-230p8rsf	110	56	virion	virion	NN
cord-269011-230p8rsf	110	57	.	.	.
cord-269011-230p8rsf	111	1	Virions	virion	NNS
cord-269011-230p8rsf	111	2	are	be	VBP
cord-269011-230p8rsf	111	3	transported	transport	VBN
cord-269011-230p8rsf	111	4	through	through	IN
cord-269011-230p8rsf	111	5	the	the	DT
cord-269011-230p8rsf	111	6	constitutive	constitutive	JJ
cord-269011-230p8rsf	111	7	secretory	secretory	JJ
cord-269011-230p8rsf	111	8	pathway	pathway	NN
cord-269011-230p8rsf	111	9	out	out	IN
cord-269011-230p8rsf	111	10	of	of	IN
cord-269011-230p8rsf	111	11	the	the	DT
cord-269011-230p8rsf	111	12	cell	cell	NN
cord-269011-230p8rsf	111	13	-	-	:
cord-269011-230p8rsf	111	14	the	the	DT
cord-269011-230p8rsf	111	15	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	111	16	on	on	IN
cord-269011-230p8rsf	111	17	their	-PRON-	PRP$
cord-269011-230p8rsf	111	18	way	way	NN
cord-269011-230p8rsf	111	19	being	be	VBG
cord-269011-230p8rsf	111	20	modified	modify	VBN
cord-269011-230p8rsf	111	21	in	in	IN
cord-269011-230p8rsf	111	22	their	-PRON-	PRP$
cord-269011-230p8rsf	111	23	sugar	sugar	NN
cord-269011-230p8rsf	111	24	moieties	moiety	NNS
cord-269011-230p8rsf	111	25	,	,	,
cord-269011-230p8rsf	111	26	whereas	whereas	IN
cord-269011-230p8rsf	111	27	the	the	DT
cord-269011-230p8rsf	111	28	S	S	NNP
cord-269011-230p8rsf	111	29	proteins	protein	NNS
cord-269011-230p8rsf	111	30	of	of	IN
cord-269011-230p8rsf	111	31	some	some	DT
cord-269011-230p8rsf	111	32	but	but	CC
cord-269011-230p8rsf	111	33	not	not	RB
cord-269011-230p8rsf	111	34	all	all	DT
cord-269011-230p8rsf	111	35	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	111	36	are	be	VBP
cord-269011-230p8rsf	111	37	cleaved	cleave	VBN
cord-269011-230p8rsf	111	38	into	into	IN
cord-269011-230p8rsf	111	39	two	two	CD
cord-269011-230p8rsf	111	40	subunits	subunit	NNS
cord-269011-230p8rsf	111	41	by	by	IN
cord-269011-230p8rsf	111	42	furin	furin	NN
cord-269011-230p8rsf	111	43	-	-	HYPH
cord-269011-230p8rsf	111	44	like	like	JJ
cord-269011-230p8rsf	111	45	enzymes	enzyme	NNS
cord-269011-230p8rsf	111	46	(	(	-LRB-
cord-269011-230p8rsf	111	47	see	see	VB
cord-269011-230p8rsf	111	48	text	text	NN
cord-269011-230p8rsf	111	49	for	for	IN
cord-269011-230p8rsf	111	50	references	reference	NNS
cord-269011-230p8rsf	111	51	)	)	-RRB-
cord-269011-230p8rsf	111	52	.	.	.
cord-269011-230p8rsf	112	1	using	use	VBG
cord-269011-230p8rsf	112	2	a	a	DT
cord-269011-230p8rsf	112	3	ribosomal	ribosomal	JJ
cord-269011-230p8rsf	112	4	frameshift	frameshift	NN
cord-269011-230p8rsf	112	5	mechanism	mechanism	NN
cord-269011-230p8rsf	112	6	for	for	IN
cord-269011-230p8rsf	112	7	which	which	WDT
cord-269011-230p8rsf	112	8	a	a	DT
cord-269011-230p8rsf	112	9	"	"	``
cord-269011-230p8rsf	112	10	slippery	slippery	JJ
cord-269011-230p8rsf	112	11	"	"	''
cord-269011-230p8rsf	112	12	sequence	sequence	NN
cord-269011-230p8rsf	112	13	and	and	CC
cord-269011-230p8rsf	112	14	a	a	DT
cord-269011-230p8rsf	112	15	pseudoknot	pseudoknot	NN
cord-269011-230p8rsf	112	16	structure	structure	NN
cord-269011-230p8rsf	112	17	are	be	VBP
cord-269011-230p8rsf	112	18	required	require	VBN
cord-269011-230p8rsf	112	19	.	.	.
cord-269011-230p8rsf	113	1	The	the	DT
cord-269011-230p8rsf	113	2	genes	gene	NNS
cord-269011-230p8rsf	113	3	located	locate	VBN
cord-269011-230p8rsf	113	4	downstream	downstream	RB
cord-269011-230p8rsf	113	5	of	of	IN
cord-269011-230p8rsf	113	6	pol1b	pol1b	NNP
cord-269011-230p8rsf	113	7	are	be	VBP
cord-269011-230p8rsf	113	8	expressed	express	VBN
cord-269011-230p8rsf	113	9	from	from	IN
cord-269011-230p8rsf	113	10	a	a	DT
cord-269011-230p8rsf	113	11	3	3	CD
cord-269011-230p8rsf	113	12	0	0	CD
cord-269011-230p8rsf	113	13	-coterminal	-coterminal	JJ
cord-269011-230p8rsf	113	14	nested	nested	JJ
cord-269011-230p8rsf	113	15	set	set	NN
cord-269011-230p8rsf	113	16	of	of	IN
cord-269011-230p8rsf	113	17	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	113	18	(	(	-LRB-
cord-269011-230p8rsf	113	19	sg	sg	NNP
cord-269011-230p8rsf	113	20	)	)	-RRB-
cord-269011-230p8rsf	113	21	RNAs	RNAs	NNPS
cord-269011-230p8rsf	113	22	,	,	,
cord-269011-230p8rsf	113	23	each	each	DT
cord-269011-230p8rsf	113	24	of	of	IN
cord-269011-230p8rsf	113	25	which	which	WDT
cord-269011-230p8rsf	113	26	additionally	additionally	RB
cord-269011-230p8rsf	113	27	contains	contain	VBZ
cord-269011-230p8rsf	113	28	a	a	DT
cord-269011-230p8rsf	113	29	short	short	JJ
cord-269011-230p8rsf	113	30	5	5	CD
cord-269011-230p8rsf	113	31	0	0	CD
cord-269011-230p8rsf	113	32	leader	leader	NN
cord-269011-230p8rsf	113	33	sequence	sequence	NN
cord-269011-230p8rsf	113	34	derived	derive	VBN
cord-269011-230p8rsf	113	35	from	from	IN
cord-269011-230p8rsf	113	36	the	the	DT
cord-269011-230p8rsf	113	37	5	5	CD
cord-269011-230p8rsf	113	38	0	0	CD
cord-269011-230p8rsf	113	39	end	end	NN
cord-269011-230p8rsf	113	40	of	of	IN
cord-269011-230p8rsf	113	41	the	the	DT
cord-269011-230p8rsf	113	42	genome	genome	NN
cord-269011-230p8rsf	113	43	.	.	.
cord-269011-230p8rsf	114	1	Transcription	transcription	NN
cord-269011-230p8rsf	114	2	regulatory	regulatory	JJ
cord-269011-230p8rsf	114	3	sequences	sequence	NNS
cord-269011-230p8rsf	114	4	(	(	-LRB-
cord-269011-230p8rsf	114	5	TRSs	TRSs	NNP
cord-269011-230p8rsf	114	6	)	)	-RRB-
cord-269011-230p8rsf	114	7	located	locate	VBN
cord-269011-230p8rsf	114	8	upstream	upstream	RB
cord-269011-230p8rsf	114	9	of	of	IN
cord-269011-230p8rsf	114	10	each	each	DT
cord-269011-230p8rsf	114	11	gene	gene	NN
cord-269011-230p8rsf	114	12	serve	serve	VBP
cord-269011-230p8rsf	114	13	as	as	IN
cord-269011-230p8rsf	114	14	signals	signal	NNS
cord-269011-230p8rsf	114	15	for	for	IN
cord-269011-230p8rsf	114	16	transcription	transcription	NN
cord-269011-230p8rsf	114	17	of	of	IN
cord-269011-230p8rsf	114	18	the	the	DT
cord-269011-230p8rsf	114	19	sgRNAs	sgrna	NNS
cord-269011-230p8rsf	114	20	.	.	.
cord-269011-230p8rsf	115	1	The	the	DT
cord-269011-230p8rsf	115	2	leader	leader	NN
cord-269011-230p8rsf	115	3	sequence	sequence	NN
cord-269011-230p8rsf	115	4	is	be	VBZ
cord-269011-230p8rsf	115	5	joined	join	VBN
cord-269011-230p8rsf	115	6	at	at	IN
cord-269011-230p8rsf	115	7	a	a	DT
cord-269011-230p8rsf	115	8	TRS	TRS	NNP
cord-269011-230p8rsf	115	9	to	to	IN
cord-269011-230p8rsf	115	10	all	all	DT
cord-269011-230p8rsf	115	11	genomic	genomic	JJ
cord-269011-230p8rsf	115	12	sequence	sequence	NN
cord-269011-230p8rsf	115	13	distal	distal	JJ
cord-269011-230p8rsf	115	14	to	to	IN
cord-269011-230p8rsf	115	15	that	that	DT
cord-269011-230p8rsf	115	16	TRS	TRS	NNP
cord-269011-230p8rsf	115	17	by	by	IN
cord-269011-230p8rsf	115	18	discontinuous	discontinuous	JJ
cord-269011-230p8rsf	115	19	transcription	transcription	NN
cord-269011-230p8rsf	115	20	,	,	,
cord-269011-230p8rsf	115	21	most	most	RBS
cord-269011-230p8rsf	115	22	likely	likely	JJ
cord-269011-230p8rsf	115	23	during	during	IN
cord-269011-230p8rsf	115	24	the	the	DT
cord-269011-230p8rsf	115	25	synthesis	synthesis	NN
cord-269011-230p8rsf	115	26	of	of	IN
cord-269011-230p8rsf	115	27	negative	negative	JJ
cord-269011-230p8rsf	115	28	-	-	HYPH
cord-269011-230p8rsf	115	29	strand	strand	NN
cord-269011-230p8rsf	115	30	sgRNAs	sgrna	NNS
cord-269011-230p8rsf	115	31	(	(	-LRB-
cord-269011-230p8rsf	115	32	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	115	33	and	and	CC
cord-269011-230p8rsf	115	34	Sawicki	Sawicki	NNP
cord-269011-230p8rsf	115	35	,	,	,
cord-269011-230p8rsf	115	36	1998	1998	CD
cord-269011-230p8rsf	115	37	)	)	-RRB-
cord-269011-230p8rsf	115	38	.	.	.
cord-269011-230p8rsf	116	1	Besides	besides	IN
cord-269011-230p8rsf	116	2	the	the	DT
cord-269011-230p8rsf	116	3	characteristic	characteristic	JJ
cord-269011-230p8rsf	116	4	genes	gene	NNS
cord-269011-230p8rsf	116	5	encoding	encode	VBG
cord-269011-230p8rsf	116	6	the	the	DT
cord-269011-230p8rsf	116	7	replicative	replicative	JJ
cord-269011-230p8rsf	116	8	and	and	CC
cord-269011-230p8rsf	116	9	structural	structural	JJ
cord-269011-230p8rsf	116	10	functions	function	NNS
cord-269011-230p8rsf	116	11	,	,	,
cord-269011-230p8rsf	116	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	116	13	have	have	VBP
cord-269011-230p8rsf	116	14	a	a	DT
cord-269011-230p8rsf	116	15	more	more	RBR
cord-269011-230p8rsf	116	16	variable	variable	JJ
cord-269011-230p8rsf	116	17	collection	collection	NN
cord-269011-230p8rsf	116	18	of	of	IN
cord-269011-230p8rsf	116	19	additional	additional	JJ
cord-269011-230p8rsf	116	20	genes	gene	NNS
cord-269011-230p8rsf	116	21	that	that	WDT
cord-269011-230p8rsf	116	22	are	be	VBP
cord-269011-230p8rsf	116	23	located	locate	VBN
cord-269011-230p8rsf	116	24	in	in	IN
cord-269011-230p8rsf	116	25	two	two	CD
cord-269011-230p8rsf	116	26	clusters	cluster	NNS
cord-269011-230p8rsf	116	27	in	in	IN
cord-269011-230p8rsf	116	28	the	the	DT
cord-269011-230p8rsf	116	29	3	3	CD
cord-269011-230p8rsf	116	30	0	0	CD
cord-269011-230p8rsf	116	31	-terminal	-terminal	JJ
cord-269011-230p8rsf	116	32	onethird	onethird	NN
cord-269011-230p8rsf	116	33	of	of	IN
cord-269011-230p8rsf	116	34	the	the	DT
cord-269011-230p8rsf	116	35	genome	genome	NN
cord-269011-230p8rsf	116	36	.	.	.
cord-269011-230p8rsf	117	1	The	the	DT
cord-269011-230p8rsf	117	2	genes	gene	NNS
cord-269011-230p8rsf	117	3	differ	differ	VBP
cord-269011-230p8rsf	117	4	distinctly	distinctly	RB
cord-269011-230p8rsf	117	5	in	in	IN
cord-269011-230p8rsf	117	6	their	-PRON-	PRP$
cord-269011-230p8rsf	117	7	nature	nature	NN
cord-269011-230p8rsf	117	8	and	and	CC
cord-269011-230p8rsf	117	9	genomic	genomic	JJ
cord-269011-230p8rsf	117	10	position	position	NN
cord-269011-230p8rsf	117	11	among	among	IN
cord-269011-230p8rsf	117	12	the	the	DT
cord-269011-230p8rsf	117	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	117	14	groups	group	NNS
cord-269011-230p8rsf	117	15	,	,	,
cord-269011-230p8rsf	117	16	but	but	CC
cord-269011-230p8rsf	117	17	they	-PRON-	PRP
cord-269011-230p8rsf	117	18	are	be	VBP
cord-269011-230p8rsf	117	19	specific	specific	JJ
cord-269011-230p8rsf	117	20	for	for	IN
cord-269011-230p8rsf	117	21	each	each	DT
cord-269011-230p8rsf	117	22	group	group	NN
cord-269011-230p8rsf	117	23	.	.	.
cord-269011-230p8rsf	118	1	These	these	DT
cord-269011-230p8rsf	118	2	so	so	RB
cord-269011-230p8rsf	118	3	-	-	HYPH
cord-269011-230p8rsf	118	4	called	call	VBN
cord-269011-230p8rsf	118	5	group	group	NN
cord-269011-230p8rsf	118	6	-	-	HYPH
cord-269011-230p8rsf	118	7	specific	specific	JJ
cord-269011-230p8rsf	118	8	genes	gene	NNS
cord-269011-230p8rsf	118	9	appear	appear	VBP
cord-269011-230p8rsf	118	10	not	not	RB
cord-269011-230p8rsf	118	11	to	to	TO
cord-269011-230p8rsf	118	12	be	be	VB
cord-269011-230p8rsf	118	13	essential	essential	JJ
cord-269011-230p8rsf	118	14	as	as	IN
cord-269011-230p8rsf	118	15	shown	show	VBN
cord-269011-230p8rsf	118	16	by	by	IN
cord-269011-230p8rsf	118	17	the	the	DT
cord-269011-230p8rsf	118	18	occurrence	occurrence	NN
cord-269011-230p8rsf	118	19	of	of	IN
cord-269011-230p8rsf	118	20	natural	natural	JJ
cord-269011-230p8rsf	118	21	mutants	mutant	NNS
cord-269011-230p8rsf	118	22	defective	defective	JJ
cord-269011-230p8rsf	118	23	in	in	IN
cord-269011-230p8rsf	118	24	some	some	DT
cord-269011-230p8rsf	118	25	of	of	IN
cord-269011-230p8rsf	118	26	them	-PRON-	PRP
cord-269011-230p8rsf	118	27	(	(	-LRB-
cord-269011-230p8rsf	118	28	Brown	Brown	NNP
cord-269011-230p8rsf	118	29	and	and	CC
cord-269011-230p8rsf	118	30	Brierley	Brierley	NNP
cord-269011-230p8rsf	118	31	,	,	,
cord-269011-230p8rsf	118	32	1995	1995	CD
cord-269011-230p8rsf	118	33	;	;	:
cord-269011-230p8rsf	118	34	Herrewegh	Herrewegh	NNP
cord-269011-230p8rsf	118	35	et	et	NNP
cord-269011-230p8rsf	118	36	al	al	NNP
cord-269011-230p8rsf	118	37	.	.	NNP
cord-269011-230p8rsf	118	38	,	,	,
cord-269011-230p8rsf	118	39	1995	1995	CD
cord-269011-230p8rsf	118	40	;	;	:
cord-269011-230p8rsf	118	41	Kennedy	Kennedy	NNP
cord-269011-230p8rsf	118	42	et	et	NNP
cord-269011-230p8rsf	118	43	al	al	NNP
cord-269011-230p8rsf	118	44	.	.	NNP
cord-269011-230p8rsf	118	45	,	,	,
cord-269011-230p8rsf	118	46	2001	2001	CD
cord-269011-230p8rsf	118	47	;	;	:
cord-269011-230p8rsf	118	48	Luytjes	Luytjes	NNP
cord-269011-230p8rsf	118	49	,	,	,
cord-269011-230p8rsf	118	50	1995	1995	CD
cord-269011-230p8rsf	118	51	;	;	:
cord-269011-230p8rsf	118	52	Shen	Shen	NNP
cord-269011-230p8rsf	118	53	et	et	NNP
cord-269011-230p8rsf	118	54	al	al	NNP
cord-269011-230p8rsf	118	55	.	.	NNP
cord-269011-230p8rsf	118	56	,	,	,
cord-269011-230p8rsf	118	57	2003	2003	CD
cord-269011-230p8rsf	118	58	;	;	:
cord-269011-230p8rsf	118	59	Vennema	Vennema	NNP
cord-269011-230p8rsf	118	60	,	,	,
cord-269011-230p8rsf	118	61	1999	1999	CD
cord-269011-230p8rsf	118	62	;	;	:
cord-269011-230p8rsf	118	63	Vennema	Vennema	NNP
cord-269011-230p8rsf	118	64	et	et	FW
cord-269011-230p8rsf	118	65	al	al	NNP
cord-269011-230p8rsf	118	66	.	.	NNP
cord-269011-230p8rsf	118	67	,	,	,
cord-269011-230p8rsf	118	68	1998	1998	CD
cord-269011-230p8rsf	118	69	;	;	:
cord-269011-230p8rsf	118	70	Woods	Woods	NNP
cord-269011-230p8rsf	118	71	,	,	,
cord-269011-230p8rsf	118	72	2001	2001	CD
cord-269011-230p8rsf	118	73	)	)	-RRB-
cord-269011-230p8rsf	118	74	and	and	CC
cord-269011-230p8rsf	118	75	by	by	IN
cord-269011-230p8rsf	118	76	the	the	DT
cord-269011-230p8rsf	118	77	observed	observed	JJ
cord-269011-230p8rsf	118	78	viability	viability	NN
cord-269011-230p8rsf	118	79	of	of	IN
cord-269011-230p8rsf	118	80	engineered	engineer	VBN
cord-269011-230p8rsf	118	81	deletion	deletion	NN
cord-269011-230p8rsf	118	82	mutants	mutant	NNS
cord-269011-230p8rsf	118	83	lacking	lack	VBG
cord-269011-230p8rsf	118	84	some	some	DT
cord-269011-230p8rsf	118	85	or	or	CC
cord-269011-230p8rsf	118	86	all	all	DT
cord-269011-230p8rsf	118	87	of	of	IN
cord-269011-230p8rsf	118	88	these	these	DT
cord-269011-230p8rsf	118	89	genes	gene	NNS
cord-269011-230p8rsf	118	90	(	(	-LRB-
cord-269011-230p8rsf	118	91	de	de	FW
cord-269011-230p8rsf	118	92	Haan	Haan	NNP
cord-269011-230p8rsf	118	93	et	et	FW
cord-269011-230p8rsf	118	94	al	al	NNP
cord-269011-230p8rsf	118	95	.	.	NNP
cord-269011-230p8rsf	118	96	,	,	,
cord-269011-230p8rsf	118	97	2002b	2002b	CD
cord-269011-230p8rsf	118	98	;	;	:
cord-269011-230p8rsf	118	99	Fischer	Fischer	NNP
cord-269011-230p8rsf	118	100	et	et	NNP
cord-269011-230p8rsf	118	101	al	al	NNP
cord-269011-230p8rsf	118	102	.	.	NNP
cord-269011-230p8rsf	118	103	,	,	,
cord-269011-230p8rsf	118	104	1997	1997	CD
cord-269011-230p8rsf	118	105	;	;	:
cord-269011-230p8rsf	118	106	Haijema	Haijema	NNP
cord-269011-230p8rsf	118	107	et	et	NNP
cord-269011-230p8rsf	118	108	al	al	NNP
cord-269011-230p8rsf	118	109	.	.	NNP
cord-269011-230p8rsf	118	110	,	,	,
cord-269011-230p8rsf	118	111	2004	2004	CD
cord-269011-230p8rsf	118	112	;	;	:
cord-269011-230p8rsf	118	113	Ortego	Ortego	NNP
cord-269011-230p8rsf	118	114	et	et	NNP
cord-269011-230p8rsf	118	115	al	al	NNP
cord-269011-230p8rsf	118	116	.	.	NNP
cord-269011-230p8rsf	118	117	,	,	,
cord-269011-230p8rsf	118	118	2003	2003	CD
cord-269011-230p8rsf	118	119	;	;	:
cord-269011-230p8rsf	118	120	Sola	Sola	NNP
cord-269011-230p8rsf	118	121	et	et	FW
cord-269011-230p8rsf	118	122	al	al	NNP
cord-269011-230p8rsf	118	123	.	.	NNP
cord-269011-230p8rsf	118	124	,	,	,
cord-269011-230p8rsf	118	125	2001	2001	CD
cord-269011-230p8rsf	118	126	)	)	-RRB-
cord-269011-230p8rsf	118	127	.	.	.
cord-269011-230p8rsf	119	1	Except	except	IN
cord-269011-230p8rsf	119	2	for	for	IN
cord-269011-230p8rsf	119	3	the	the	DT
cord-269011-230p8rsf	119	4	group	group	NN
cord-269011-230p8rsf	119	5	2-specific	2-specific	CD
cord-269011-230p8rsf	119	6	HE	HE	NNP
cord-269011-230p8rsf	119	7	protein	protein	NN
cord-269011-230p8rsf	119	8	and	and	CC
cord-269011-230p8rsf	119	9	,	,	,
cord-269011-230p8rsf	119	10	possibly	possibly	RB
cord-269011-230p8rsf	119	11	,	,	,
cord-269011-230p8rsf	119	12	the	the	DT
cord-269011-230p8rsf	119	13	poorly	poorly	RB
cord-269011-230p8rsf	119	14	characterized	characterize	VBN
cord-269011-230p8rsf	119	15	I	-PRON-	PRP
cord-269011-230p8rsf	119	16	protein	protein	NN
cord-269011-230p8rsf	119	17	(	(	-LRB-
cord-269011-230p8rsf	119	18	Fischer	Fischer	NNP
cord-269011-230p8rsf	119	19	et	et	NNP
cord-269011-230p8rsf	119	20	al	al	NNP
cord-269011-230p8rsf	119	21	.	.	NNP
cord-269011-230p8rsf	119	22	,	,	,
cord-269011-230p8rsf	119	23	1997	1997	CD
cord-269011-230p8rsf	119	24	;	;	:
cord-269011-230p8rsf	119	25	Senanayake	Senanayake	NNP
cord-269011-230p8rsf	119	26	et	et	FW
cord-269011-230p8rsf	119	27	al	al	NNP
cord-269011-230p8rsf	119	28	.	.	NNP
cord-269011-230p8rsf	119	29	,	,	,
cord-269011-230p8rsf	119	30	1992	1992	CD
cord-269011-230p8rsf	119	31	)	)	-RRB-
cord-269011-230p8rsf	119	32	,	,	,
cord-269011-230p8rsf	119	33	the	the	DT
cord-269011-230p8rsf	119	34	latter	latter	JJ
cord-269011-230p8rsf	119	35	encoded	encode	VBN
cord-269011-230p8rsf	119	36	by	by	IN
cord-269011-230p8rsf	119	37	an	an	DT
cord-269011-230p8rsf	119	38	open	open	JJ
cord-269011-230p8rsf	119	39	reading	reading	NN
cord-269011-230p8rsf	119	40	frame	frame	NN
cord-269011-230p8rsf	119	41	completely	completely	RB
cord-269011-230p8rsf	119	42	contained	contain	VBN
cord-269011-230p8rsf	119	43	within	within	IN
cord-269011-230p8rsf	119	44	the	the	DT
cord-269011-230p8rsf	119	45	N	n	CD
cord-269011-230p8rsf	119	46	gene	gene	NN
cord-269011-230p8rsf	119	47	,	,	,
cord-269011-230p8rsf	119	48	the	the	DT
cord-269011-230p8rsf	119	49	group-	group-	NN
cord-269011-230p8rsf	120	1	The	the	DT
cord-269011-230p8rsf	120	2	single	single	RB
cord-269011-230p8rsf	120	3	-	-	HYPH
cord-269011-230p8rsf	120	4	stranded	stranded	JJ
cord-269011-230p8rsf	120	5	,	,	,
cord-269011-230p8rsf	120	6	positive	positive	JJ
cord-269011-230p8rsf	120	7	-	-	HYPH
cord-269011-230p8rsf	120	8	sense	sense	NN
cord-269011-230p8rsf	120	9	RNA	RNA	NNP
cord-269011-230p8rsf	120	10	genome	genome	NN
cord-269011-230p8rsf	120	11	contains	contain	VBZ
cord-269011-230p8rsf	120	12	5	5	CD
cord-269011-230p8rsf	120	13	0	0	CD
cord-269011-230p8rsf	120	14	-and	-and	SYM
cord-269011-230p8rsf	120	15	3	3	CD
cord-269011-230p8rsf	120	16	0	0	CD
cord-269011-230p8rsf	120	17	-terminal	-terminal	JJ
cord-269011-230p8rsf	120	18	untranslated	untranslated	JJ
cord-269011-230p8rsf	120	19	regions	region	NNS
cord-269011-230p8rsf	120	20	(	(	-LRB-
cord-269011-230p8rsf	120	21	UTRs	UTRs	NNP
cord-269011-230p8rsf	120	22	)	)	-RRB-
cord-269011-230p8rsf	120	23	with	with	IN
cord-269011-230p8rsf	120	24	a	a	DT
cord-269011-230p8rsf	120	25	5	5	CD
cord-269011-230p8rsf	120	26	0	0	CD
cord-269011-230p8rsf	120	27	-terminal	-terminal	JJ
cord-269011-230p8rsf	120	28	cap	cap	NN
cord-269011-230p8rsf	120	29	and	and	CC
cord-269011-230p8rsf	120	30	a	a	DT
cord-269011-230p8rsf	120	31	3	3	CD
cord-269011-230p8rsf	120	32	0	0	CD
cord-269011-230p8rsf	120	33	-terminal	-terminal	JJ
cord-269011-230p8rsf	120	34	poly(A	poly(a	JJ
cord-269011-230p8rsf	120	35	)	)	-RRB-
cord-269011-230p8rsf	120	36	tract	tract	NN
cord-269011-230p8rsf	120	37	.	.	.
cord-269011-230p8rsf	121	1	The	the	DT
cord-269011-230p8rsf	121	2	leader	leader	NN
cord-269011-230p8rsf	121	3	sequence	sequence	NN
cord-269011-230p8rsf	121	4	(	(	-LRB-
cord-269011-230p8rsf	121	5	L	L	NNP
cord-269011-230p8rsf	121	6	)	)	-RRB-
cord-269011-230p8rsf	121	7	in	in	IN
cord-269011-230p8rsf	121	8	the	the	DT
cord-269011-230p8rsf	121	9	5	5	CD
cord-269011-230p8rsf	121	10	0	0	CD
cord-269011-230p8rsf	121	11	UTR	UTR	NNP
cord-269011-230p8rsf	121	12	is	be	VBZ
cord-269011-230p8rsf	121	13	indicated	indicate	VBN
cord-269011-230p8rsf	121	14	.	.	.
cord-269011-230p8rsf	122	1	All	all	DT
cord-269011-230p8rsf	122	2	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	122	3	have	have	VBP
cord-269011-230p8rsf	122	4	their	-PRON-	PRP$
cord-269011-230p8rsf	122	5	essential	essential	JJ
cord-269011-230p8rsf	122	6	genes	gene	NNS
cord-269011-230p8rsf	122	7	in	in	IN
cord-269011-230p8rsf	122	8	the	the	DT
cord-269011-230p8rsf	122	9	order	order	NN
cord-269011-230p8rsf	122	10	5	5	CD
cord-269011-230p8rsf	122	11	0	0	CD
cord-269011-230p8rsf	122	12	-pol	-pol	:
cord-269011-230p8rsf	122	13	-	-	HYPH
cord-269011-230p8rsf	122	14	S	s	NN
cord-269011-230p8rsf	122	15	-	-	HYPH
cord-269011-230p8rsf	122	16	E	E	NNP
cord-269011-230p8rsf	122	17	-	-	HYPH
cord-269011-230p8rsf	122	18	M	M	NNP
cord-269011-230p8rsf	122	19	-	-	HYPH
cord-269011-230p8rsf	122	20	N-3	N-3	NNP
cord-269011-230p8rsf	122	21	0	0	CD
cord-269011-230p8rsf	122	22	.	.	.
cord-269011-230p8rsf	123	1	The	the	DT
cord-269011-230p8rsf	123	2	pol1a	pol1a	VBN
cord-269011-230p8rsf	123	3	and	and	CC
cord-269011-230p8rsf	123	4	pol1b	pol1b	JJ
cord-269011-230p8rsf	123	5	genes	gene	NNS
cord-269011-230p8rsf	123	6	comprise	comprise	VBP
cord-269011-230p8rsf	123	7	approximately	approximately	RB
cord-269011-230p8rsf	123	8	twothirds	twothird	NNS
cord-269011-230p8rsf	123	9	of	of	IN
cord-269011-230p8rsf	123	10	the	the	DT
cord-269011-230p8rsf	123	11	genome	genome	NN
cord-269011-230p8rsf	123	12	.	.	.
cord-269011-230p8rsf	124	1	The	the	DT
cord-269011-230p8rsf	124	2	more	more	RBR
cord-269011-230p8rsf	124	3	downstream	downstream	JJ
cord-269011-230p8rsf	124	4	pol1b	pol1b	JJ
cord-269011-230p8rsf	124	5	gene	gene	NN
cord-269011-230p8rsf	124	6	is	be	VBZ
cord-269011-230p8rsf	124	7	translated	translate	VBN
cord-269011-230p8rsf	124	8	by	by	IN
cord-269011-230p8rsf	124	9	translational	translational	JJ
cord-269011-230p8rsf	124	10	readthrough	readthrough	NN
cord-269011-230p8rsf	124	11	,	,	,
cord-269011-230p8rsf	124	12	using	use	VBG
cord-269011-230p8rsf	124	13	a	a	DT
cord-269011-230p8rsf	124	14	ribosomal	ribosomal	JJ
cord-269011-230p8rsf	124	15	frameshift	frameshift	NN
cord-269011-230p8rsf	124	16	mechanism	mechanism	NN
cord-269011-230p8rsf	124	17	.	.	.
cord-269011-230p8rsf	125	1	Transcription	transcription	NN
cord-269011-230p8rsf	125	2	regulatory	regulatory	JJ
cord-269011-230p8rsf	125	3	sequences	sequence	NNS
cord-269011-230p8rsf	125	4	(	(	-LRB-
cord-269011-230p8rsf	125	5	TRSs	TRSs	NNP
cord-269011-230p8rsf	125	6	)	)	-RRB-
cord-269011-230p8rsf	125	7	located	locate	VBN
cord-269011-230p8rsf	125	8	upstream	upstream	RB
cord-269011-230p8rsf	125	9	of	of	IN
cord-269011-230p8rsf	125	10	each	each	DT
cord-269011-230p8rsf	125	11	gene	gene	NN
cord-269011-230p8rsf	125	12	,	,	,
cord-269011-230p8rsf	125	13	which	which	WDT
cord-269011-230p8rsf	125	14	serve	serve	VBP
cord-269011-230p8rsf	125	15	as	as	IN
cord-269011-230p8rsf	125	16	signals	signal	NNS
cord-269011-230p8rsf	125	17	for	for	IN
cord-269011-230p8rsf	125	18	the	the	DT
cord-269011-230p8rsf	125	19	transcription	transcription	NN
cord-269011-230p8rsf	125	20	of	of	IN
cord-269011-230p8rsf	125	21	the	the	DT
cord-269011-230p8rsf	125	22	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	125	23	(	(	-LRB-
cord-269011-230p8rsf	125	24	sg	sg	NNP
cord-269011-230p8rsf	125	25	)	)	-RRB-
cord-269011-230p8rsf	125	26	RNAs	RNAs	NNPS
cord-269011-230p8rsf	125	27	,	,	,
cord-269011-230p8rsf	125	28	are	be	VBP
cord-269011-230p8rsf	125	29	indicated	indicate	VBN
cord-269011-230p8rsf	125	30	by	by	IN
cord-269011-230p8rsf	125	31	circles	circle	NNS
cord-269011-230p8rsf	125	32	.	.	.
cord-269011-230p8rsf	126	1	The	the	DT
cord-269011-230p8rsf	126	2	genes	gene	NNS
cord-269011-230p8rsf	126	3	encoding	encode	VBG
cord-269011-230p8rsf	126	4	the	the	DT
cord-269011-230p8rsf	126	5	structural	structural	JJ
cord-269011-230p8rsf	126	6	proteins	protein	NNS
cord-269011-230p8rsf	127	1	HE	HE	NNP
cord-269011-230p8rsf	127	2	,	,	,
cord-269011-230p8rsf	127	3	S	S	NNP
cord-269011-230p8rsf	127	4	,	,	,
cord-269011-230p8rsf	127	5	E	E	NNP
cord-269011-230p8rsf	127	6	,	,	,
cord-269011-230p8rsf	127	7	M	M	NNP
cord-269011-230p8rsf	127	8	,	,	,
cord-269011-230p8rsf	127	9	and	and	CC
cord-269011-230p8rsf	127	10	N	n	CD
cord-269011-230p8rsf	127	11	are	be	VBP
cord-269011-230p8rsf	127	12	specified	specify	VBN
cord-269011-230p8rsf	127	13	.	.	.
cord-269011-230p8rsf	128	1	Gray	gray	JJ
cord-269011-230p8rsf	128	2	boxes	box	NNS
cord-269011-230p8rsf	128	3	indicate	indicate	VBP
cord-269011-230p8rsf	128	4	the	the	DT
cord-269011-230p8rsf	128	5	accessory	accessory	NN
cord-269011-230p8rsf	128	6	,	,	,
cord-269011-230p8rsf	128	7	group	group	NN
cord-269011-230p8rsf	128	8	-	-	HYPH
cord-269011-230p8rsf	128	9	specific	specific	JJ
cord-269011-230p8rsf	128	10	genes	gene	NNS
cord-269011-230p8rsf	128	11	,	,	,
cord-269011-230p8rsf	128	12	in	in	IN
cord-269011-230p8rsf	128	13	the	the	DT
cord-269011-230p8rsf	128	14	case	case	NN
cord-269011-230p8rsf	128	15	of	of	IN
cord-269011-230p8rsf	128	16	group	group	NN
cord-269011-230p8rsf	128	17	2	2	CD
cord-269011-230p8rsf	128	18	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	128	19	genes	gene	NNS
cord-269011-230p8rsf	128	20	2a	2a	CD
cord-269011-230p8rsf	128	21	,	,	,
cord-269011-230p8rsf	128	22	HE	HE	NNP
cord-269011-230p8rsf	128	23	,	,	,
cord-269011-230p8rsf	128	24	4	4	CD
cord-269011-230p8rsf	128	25	,	,	,
cord-269011-230p8rsf	128	26	5a	5a	CD
cord-269011-230p8rsf	128	27	,	,	,
cord-269011-230p8rsf	128	28	and	and	CC
cord-269011-230p8rsf	128	29	I.	I.	NNP
cord-269011-230p8rsf	128	30	specific	specific	JJ
cord-269011-230p8rsf	128	31	proteins	protein	NNS
cord-269011-230p8rsf	128	32	do	do	VBP
cord-269011-230p8rsf	128	33	not	not	RB
cord-269011-230p8rsf	128	34	appear	appear	VB
cord-269011-230p8rsf	128	35	to	to	TO
cord-269011-230p8rsf	128	36	occur	occur	VB
cord-269011-230p8rsf	128	37	in	in	IN
cord-269011-230p8rsf	128	38	virions	virion	NNS
cord-269011-230p8rsf	128	39	.	.	.
cord-269011-230p8rsf	129	1	Although	although	IN
cord-269011-230p8rsf	129	2	their	-PRON-	PRP$
cord-269011-230p8rsf	129	3	functions	function	NNS
cord-269011-230p8rsf	129	4	have	have	VBP
cord-269011-230p8rsf	129	5	not	not	RB
cord-269011-230p8rsf	129	6	yet	yet	RB
cord-269011-230p8rsf	129	7	been	be	VBN
cord-269011-230p8rsf	129	8	resolved	resolve	VBN
cord-269011-230p8rsf	129	9	,	,	,
cord-269011-230p8rsf	129	10	mutant	mutant	JJ
cord-269011-230p8rsf	129	11	studies	study	NNS
cord-269011-230p8rsf	129	12	indicate	indicate	VBP
cord-269011-230p8rsf	129	13	that	that	IN
cord-269011-230p8rsf	129	14	they	-PRON-	PRP
cord-269011-230p8rsf	129	15	play	play	VBP
cord-269011-230p8rsf	129	16	important	important	JJ
cord-269011-230p8rsf	129	17	roles	role	NNS
cord-269011-230p8rsf	129	18	in	in	IN
cord-269011-230p8rsf	129	19	the	the	DT
cord-269011-230p8rsf	129	20	interaction	interaction	NN
cord-269011-230p8rsf	129	21	of	of	IN
cord-269011-230p8rsf	129	22	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	129	23	with	with	IN
cord-269011-230p8rsf	129	24	their	-PRON-	PRP$
cord-269011-230p8rsf	129	25	host	host	NN
cord-269011-230p8rsf	129	26	(	(	-LRB-
cord-269011-230p8rsf	129	27	de	de	FW
cord-269011-230p8rsf	129	28	Haan	Haan	NNP
cord-269011-230p8rsf	129	29	et	et	FW
cord-269011-230p8rsf	129	30	al	al	NNP
cord-269011-230p8rsf	129	31	.	.	NNP
cord-269011-230p8rsf	129	32	,	,	,
cord-269011-230p8rsf	129	33	2002b	2002b	CD
cord-269011-230p8rsf	129	34	;	;	:
cord-269011-230p8rsf	129	35	Fischer	Fischer	NNP
cord-269011-230p8rsf	129	36	et	et	NNP
cord-269011-230p8rsf	129	37	al	al	NNP
cord-269011-230p8rsf	129	38	.	.	NNP
cord-269011-230p8rsf	129	39	,	,	,
cord-269011-230p8rsf	129	40	1997	1997	CD
cord-269011-230p8rsf	129	41	;	;	:
cord-269011-230p8rsf	129	42	Haijema	Haijema	NNP
cord-269011-230p8rsf	129	43	et	et	NNP
cord-269011-230p8rsf	129	44	al	al	NNP
cord-269011-230p8rsf	129	45	.	.	NNP
cord-269011-230p8rsf	129	46	,	,	,
cord-269011-230p8rsf	129	47	2004	2004	CD
cord-269011-230p8rsf	129	48	;	;	:
cord-269011-230p8rsf	129	49	Ortego	Ortego	NNP
cord-269011-230p8rsf	129	50	et	et	NNP
cord-269011-230p8rsf	129	51	al	al	NNP
cord-269011-230p8rsf	129	52	.	.	NNP
cord-269011-230p8rsf	129	53	,	,	,
cord-269011-230p8rsf	129	54	2003	2003	CD
cord-269011-230p8rsf	129	55	)	)	-RRB-
cord-269011-230p8rsf	129	56	.	.	.
cord-269011-230p8rsf	130	1	The	the	DT
cord-269011-230p8rsf	130	2	N	N	NNP
cord-269011-230p8rsf	130	3	protein	protein	NN
cord-269011-230p8rsf	130	4	is	be	VBZ
cord-269011-230p8rsf	130	5	the	the	DT
cord-269011-230p8rsf	130	6	most	most	RBS
cord-269011-230p8rsf	130	7	abundantly	abundantly	RB
cord-269011-230p8rsf	130	8	expressed	express	VBN
cord-269011-230p8rsf	130	9	viral	viral	JJ
cord-269011-230p8rsf	130	10	protein	protein	NN
cord-269011-230p8rsf	130	11	in	in	IN
cord-269011-230p8rsf	130	12	infected	infected	JJ
cord-269011-230p8rsf	130	13	cells	cell	NNS
cord-269011-230p8rsf	130	14	(	(	-LRB-
cord-269011-230p8rsf	130	15	for	for	IN
cord-269011-230p8rsf	130	16	a	a	DT
cord-269011-230p8rsf	130	17	review	review	NN
cord-269011-230p8rsf	130	18	,	,	,
cord-269011-230p8rsf	130	19	see	see	VB
cord-269011-230p8rsf	130	20	Laude	Laude	NNP
cord-269011-230p8rsf	130	21	and	and	CC
cord-269011-230p8rsf	130	22	Masters	Masters	NNPS
cord-269011-230p8rsf	130	23	,	,	,
cord-269011-230p8rsf	130	24	1995	1995	CD
cord-269011-230p8rsf	130	25	)	)	-RRB-
cord-269011-230p8rsf	130	26	.	.	.
cord-269011-230p8rsf	131	1	Its	-PRON-	PRP$
cord-269011-230p8rsf	131	2	size	size	NN
cord-269011-230p8rsf	131	3	varies	vary	VBZ
cord-269011-230p8rsf	131	4	considerably	considerably	RB
cord-269011-230p8rsf	131	5	between	between	IN
cord-269011-230p8rsf	131	6	viruses	virus	NNS
cord-269011-230p8rsf	131	7	from	from	IN
cord-269011-230p8rsf	131	8	different	different	JJ
cord-269011-230p8rsf	131	9	groups	group	NNS
cord-269011-230p8rsf	131	10	(	(	-LRB-
cord-269011-230p8rsf	131	11	377	377	CD
cord-269011-230p8rsf	131	12	-	-	SYM
cord-269011-230p8rsf	131	13	455	455	CD
cord-269011-230p8rsf	131	14	amino	amino	JJ
cord-269011-230p8rsf	131	15	acids	acid	NNS
cord-269011-230p8rsf	131	16	,	,	,
cord-269011-230p8rsf	131	17	i.e.	i.e.	FW
cord-269011-230p8rsf	131	18	,	,	,
cord-269011-230p8rsf	131	19	molecular	molecular	JJ
cord-269011-230p8rsf	131	20	masses	masse	NNS
cord-269011-230p8rsf	131	21	ranging	range	VBG
cord-269011-230p8rsf	131	22	between	between	IN
cord-269011-230p8rsf	131	23	45	45	CD
cord-269011-230p8rsf	131	24	and	and	CC
cord-269011-230p8rsf	131	25	60	60	CD
cord-269011-230p8rsf	131	26	kDa	kDa	NNS
cord-269011-230p8rsf	131	27	)	)	-RRB-
cord-269011-230p8rsf	131	28	,	,	,
cord-269011-230p8rsf	131	29	N	n	CD
cord-269011-230p8rsf	131	30	proteins	protein	NNS
cord-269011-230p8rsf	131	31	from	from	IN
cord-269011-230p8rsf	131	32	group	group	NN
cord-269011-230p8rsf	131	33	2	2	CD
cord-269011-230p8rsf	131	34	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	131	35	(	(	-LRB-
cord-269011-230p8rsf	131	36	Table	table	NN
cord-269011-230p8rsf	131	37	I	-PRON-	PRP
cord-269011-230p8rsf	131	38	)	)	-RRB-
cord-269011-230p8rsf	131	39	being	be	VBG
cord-269011-230p8rsf	131	40	the	the	DT
cord-269011-230p8rsf	131	41	largest	large	JJS
cord-269011-230p8rsf	131	42	.	.	.
cord-269011-230p8rsf	132	1	Whereas	whereas	IN
cord-269011-230p8rsf	132	2	the	the	DT
cord-269011-230p8rsf	132	3	amino	amino	NN
cord-269011-230p8rsf	132	4	acid	acid	NN
cord-269011-230p8rsf	132	5	sequences	sequence	NNS
cord-269011-230p8rsf	132	6	of	of	IN
cord-269011-230p8rsf	132	7	N	n	CD
cord-269011-230p8rsf	132	8	proteins	protein	NNS
cord-269011-230p8rsf	132	9	are	be	VBP
cord-269011-230p8rsf	132	10	quite	quite	RB
cord-269011-230p8rsf	132	11	similar	similar	JJ
cord-269011-230p8rsf	132	12	within	within	IN
cord-269011-230p8rsf	132	13	the	the	DT
cord-269011-230p8rsf	132	14	groups	group	NNS
cord-269011-230p8rsf	132	15	,	,	,
cord-269011-230p8rsf	132	16	the	the	DT
cord-269011-230p8rsf	132	17	homology	homology	NN
cord-269011-230p8rsf	132	18	between	between	IN
cord-269011-230p8rsf	132	19	proteins	protein	NNS
cord-269011-230p8rsf	132	20	from	from	IN
cord-269011-230p8rsf	132	21	different	different	JJ
cord-269011-230p8rsf	132	22	coronavirus	coronavirus	NN
cord-269011-230p8rsf	132	23	groups	group	NNS
cord-269011-230p8rsf	132	24	is	be	VBZ
cord-269011-230p8rsf	132	25	rather	rather	RB
cord-269011-230p8rsf	132	26	limited	limited	JJ
cord-269011-230p8rsf	132	27	(	(	-LRB-
cord-269011-230p8rsf	132	28	30	30	CD
cord-269011-230p8rsf	132	29	-	-	SYM
cord-269011-230p8rsf	132	30	35	35	CD
cord-269011-230p8rsf	132	31	%	%	NN
cord-269011-230p8rsf	132	32	)	)	-RRB-
cord-269011-230p8rsf	132	33	.	.	.
cord-269011-230p8rsf	133	1	An	an	DT
cord-269011-230p8rsf	133	2	exception	exception	NN
cord-269011-230p8rsf	133	3	is	be	VBZ
cord-269011-230p8rsf	133	4	a	a	DT
cord-269011-230p8rsf	133	5	region	region	NN
cord-269011-230p8rsf	133	6	spanning	span	VBG
cord-269011-230p8rsf	133	7	about	about	IN
cord-269011-230p8rsf	133	8	50	50	CD
cord-269011-230p8rsf	133	9	residues	residue	NNS
cord-269011-230p8rsf	133	10	within	within	IN
cord-269011-230p8rsf	133	11	the	the	DT
cord-269011-230p8rsf	133	12	amino	amino	NN
cord-269011-230p8rsf	133	13	-	-	HYPH
cord-269011-230p8rsf	133	14	terminal	terminal	NN
cord-269011-230p8rsf	133	15	one	one	CD
cord-269011-230p8rsf	133	16	-	-	HYPH
cord-269011-230p8rsf	133	17	third	third	NN
cord-269011-230p8rsf	133	18	of	of	IN
cord-269011-230p8rsf	133	19	the	the	DT
cord-269011-230p8rsf	133	20	N	N	NNP
cord-269011-230p8rsf	133	21	molecule	molecule	NN
cord-269011-230p8rsf	133	22	,	,	,
cord-269011-230p8rsf	133	23	where	where	WRB
cord-269011-230p8rsf	133	24	high	high	JJ
cord-269011-230p8rsf	133	25	sequence	sequence	NN
cord-269011-230p8rsf	133	26	identity	identity	NN
cord-269011-230p8rsf	133	27	has	have	VBZ
cord-269011-230p8rsf	133	28	been	be	VBN
cord-269011-230p8rsf	133	29	conserved	conserve	VBN
cord-269011-230p8rsf	133	30	across	across	IN
cord-269011-230p8rsf	133	31	the	the	DT
cord-269011-230p8rsf	133	32	different	different	JJ
cord-269011-230p8rsf	133	33	groups	group	NNS
cord-269011-230p8rsf	133	34	.	.	.
cord-269011-230p8rsf	134	1	Despite	despite	IN
cord-269011-230p8rsf	134	2	the	the	DT
cord-269011-230p8rsf	134	3	overall	overall	JJ
cord-269011-230p8rsf	134	4	sequence	sequence	NN
cord-269011-230p8rsf	134	5	variation	variation	NN
cord-269011-230p8rsf	134	6	the	the	DT
cord-269011-230p8rsf	134	7	N	n	CD
cord-269011-230p8rsf	134	8	proteins	protein	NNS
cord-269011-230p8rsf	134	9	have	have	VBP
cord-269011-230p8rsf	134	10	a	a	DT
cord-269011-230p8rsf	134	11	number	number	NN
cord-269011-230p8rsf	134	12	of	of	IN
cord-269011-230p8rsf	134	13	common	common	JJ
cord-269011-230p8rsf	134	14	characteristics	characteristic	NNS
cord-269011-230p8rsf	134	15	.	.	.
cord-269011-230p8rsf	135	1	Consistent	consistent	JJ
cord-269011-230p8rsf	135	2	with	with	IN
cord-269011-230p8rsf	135	3	their	-PRON-	PRP$
cord-269011-230p8rsf	135	4	role	role	NN
cord-269011-230p8rsf	135	5	as	as	IN
cord-269011-230p8rsf	135	6	nucleic	nucleic	JJ
cord-269011-230p8rsf	135	7	acidbinding	acidbinding	NN
cord-269011-230p8rsf	135	8	proteins	protein	NNS
cord-269011-230p8rsf	135	9	they	-PRON-	PRP
cord-269011-230p8rsf	135	10	are	be	VBP
cord-269011-230p8rsf	135	11	all	all	DT
cord-269011-230p8rsf	135	12	highly	highly	RB
cord-269011-230p8rsf	135	13	basic	basic	JJ
cord-269011-230p8rsf	135	14	because	because	IN
cord-269011-230p8rsf	135	15	of	of	IN
cord-269011-230p8rsf	135	16	the	the	DT
cord-269011-230p8rsf	135	17	abundance	abundance	NN
cord-269011-230p8rsf	135	18	of	of	IN
cord-269011-230p8rsf	135	19	arginine	arginine	NN
cord-269011-230p8rsf	135	20	and	and	CC
cord-269011-230p8rsf	135	21	lysine	lysine	NN
cord-269011-230p8rsf	135	22	residues	residue	NNS
cord-269011-230p8rsf	135	23	.	.	.
cord-269011-230p8rsf	136	1	These	these	DT
cord-269011-230p8rsf	136	2	are	be	VBP
cord-269011-230p8rsf	136	3	clustered	cluster	VBN
cord-269011-230p8rsf	136	4	mainly	mainly	RB
cord-269011-230p8rsf	136	5	in	in	IN
cord-269011-230p8rsf	136	6	two	two	CD
cord-269011-230p8rsf	136	7	nearby	nearby	JJ
cord-269011-230p8rsf	136	8	regions	region	NNS
cord-269011-230p8rsf	136	9	in	in	IN
cord-269011-230p8rsf	136	10	the	the	DT
cord-269011-230p8rsf	136	11	middle	middle	NN
cord-269011-230p8rsf	136	12	of	of	IN
cord-269011-230p8rsf	136	13	the	the	DT
cord-269011-230p8rsf	136	14	molecules	molecule	NNS
cord-269011-230p8rsf	136	15	.	.	.
cord-269011-230p8rsf	137	1	The	the	DT
cord-269011-230p8rsf	137	2	abundance	abundance	NN
cord-269011-230p8rsf	137	3	of	of	IN
cord-269011-230p8rsf	137	4	basic	basic	JJ
cord-269011-230p8rsf	137	5	residues	residue	NNS
cord-269011-230p8rsf	137	6	is	be	VBZ
cord-269011-230p8rsf	137	7	reflected	reflect	VBN
cord-269011-230p8rsf	137	8	in	in	IN
cord-269011-230p8rsf	137	9	the	the	DT
cord-269011-230p8rsf	137	10	calculated	calculated	JJ
cord-269011-230p8rsf	137	11	overall	overall	RB
cord-269011-230p8rsf	137	12	isoelectric	isoelectric	JJ
cord-269011-230p8rsf	137	13	points	point	NNS
cord-269011-230p8rsf	137	14	of	of	IN
cord-269011-230p8rsf	137	15	the	the	DT
cord-269011-230p8rsf	137	16	N	n	CD
cord-269011-230p8rsf	137	17	proteins	protein	NNS
cord-269011-230p8rsf	137	18	,	,	,
cord-269011-230p8rsf	137	19	the	the	DT
cord-269011-230p8rsf	137	20	values	value	NNS
cord-269011-230p8rsf	137	21	of	of	IN
cord-269011-230p8rsf	137	22	which	which	WDT
cord-269011-230p8rsf	137	23	are	be	VBP
cord-269011-230p8rsf	137	24	in	in	IN
cord-269011-230p8rsf	137	25	the	the	DT
cord-269011-230p8rsf	137	26	range	range	NN
cord-269011-230p8rsf	137	27	of	of	IN
cord-269011-230p8rsf	137	28	9.7	9.7	CD
cord-269011-230p8rsf	137	29	-	-	SYM
cord-269011-230p8rsf	137	30	10.1	10.1	CD
cord-269011-230p8rsf	137	31	.	.	.
cord-269011-230p8rsf	138	1	These	these	DT
cord-269011-230p8rsf	138	2	numbers	number	NNS
cord-269011-230p8rsf	138	3	are	be	VBP
cord-269011-230p8rsf	138	4	the	the	DT
cord-269011-230p8rsf	138	5	more	more	RBR
cord-269011-230p8rsf	138	6	significant	significant	JJ
cord-269011-230p8rsf	138	7	in	in	IN
cord-269011-230p8rsf	138	8	view	view	NN
cord-269011-230p8rsf	138	9	of	of	IN
cord-269011-230p8rsf	138	10	the	the	DT
cord-269011-230p8rsf	138	11	acidic	acidic	JJ
cord-269011-230p8rsf	138	12	nature	nature	NN
cord-269011-230p8rsf	138	13	of	of	IN
cord-269011-230p8rsf	138	14	the	the	DT
cord-269011-230p8rsf	138	15	very	very	RB
cord-269011-230p8rsf	138	16	carboxyterminal	carboxyterminal	JJ
cord-269011-230p8rsf	138	17	domain	domain	NN
cord-269011-230p8rsf	138	18	;	;	:
cord-269011-230p8rsf	138	19	pI	pi	NN
cord-269011-230p8rsf	138	20	values	value	NNS
cord-269011-230p8rsf	138	21	ranging	range	VBG
cord-269011-230p8rsf	138	22	from	from	IN
cord-269011-230p8rsf	138	23	4.3	4.3	CD
cord-269011-230p8rsf	138	24	to	to	TO
cord-269011-230p8rsf	138	25	5.5	5.5	CD
cord-269011-230p8rsf	138	26	were	be	VBD
cord-269011-230p8rsf	138	27	calculated	calculate	VBN
cord-269011-230p8rsf	138	28	for	for	IN
cord-269011-230p8rsf	138	29	the	the	DT
cord-269011-230p8rsf	138	30	terminal	terminal	JJ
cord-269011-230p8rsf	138	31	45	45	CD
cord-269011-230p8rsf	138	32	residues	residue	NNS
cord-269011-230p8rsf	138	33	(	(	-LRB-
cord-269011-230p8rsf	138	34	Parker	Parker	NNP
cord-269011-230p8rsf	138	35	and	and	CC
cord-269011-230p8rsf	138	36	Masters	Masters	NNP
cord-269011-230p8rsf	138	37	,	,	,
cord-269011-230p8rsf	138	38	1990	1990	CD
cord-269011-230p8rsf	138	39	)	)	-RRB-
cord-269011-230p8rsf	138	40	.	.	.
cord-269011-230p8rsf	139	1	Another	another	DT
cord-269011-230p8rsf	139	2	general	general	JJ
cord-269011-230p8rsf	139	3	characteristic	characteristic	NN
cord-269011-230p8rsf	139	4	of	of	IN
cord-269011-230p8rsf	139	5	the	the	DT
cord-269011-230p8rsf	139	6	N	n	CD
cord-269011-230p8rsf	139	7	proteins	protein	NNS
cord-269011-230p8rsf	139	8	is	be	VBZ
cord-269011-230p8rsf	139	9	their	-PRON-	PRP$
cord-269011-230p8rsf	139	10	high	high	JJ
cord-269011-230p8rsf	139	11	content	content	NN
cord-269011-230p8rsf	139	12	(	(	-LRB-
cord-269011-230p8rsf	139	13	7	7	CD
cord-269011-230p8rsf	139	14	-	-	SYM
cord-269011-230p8rsf	139	15	11	11	CD
cord-269011-230p8rsf	139	16	%	%	NN
cord-269011-230p8rsf	139	17	)	)	-RRB-
cord-269011-230p8rsf	139	18	of	of	IN
cord-269011-230p8rsf	139	19	serine	serine	JJ
cord-269011-230p8rsf	139	20	residues	residue	NNS
cord-269011-230p8rsf	139	21	,	,	,
cord-269011-230p8rsf	139	22	which	which	WDT
cord-269011-230p8rsf	139	23	are	be	VBP
cord-269011-230p8rsf	139	24	potential	potential	JJ
cord-269011-230p8rsf	139	25	targets	target	NNS
cord-269011-230p8rsf	139	26	for	for	IN
cord-269011-230p8rsf	139	27	phosphorylation	phosphorylation	NN
cord-269011-230p8rsf	139	28	.	.	.
cord-269011-230p8rsf	140	1	Although	although	IN
cord-269011-230p8rsf	140	2	these	these	DT
cord-269011-230p8rsf	140	3	residues	residue	NNS
cord-269011-230p8rsf	140	4	occur	occur	VBP
cord-269011-230p8rsf	140	5	all	all	RB
cord-269011-230p8rsf	140	6	over	over	IN
cord-269011-230p8rsf	140	7	the	the	DT
cord-269011-230p8rsf	140	8	N	n	CD
cord-269011-230p8rsf	140	9	molecule	molecule	NN
cord-269011-230p8rsf	140	10	,	,	,
cord-269011-230p8rsf	140	11	their	-PRON-	PRP$
cord-269011-230p8rsf	140	12	relative	relative	JJ
cord-269011-230p8rsf	140	13	abundance	abundance	NN
cord-269011-230p8rsf	140	14	within	within	IN
cord-269011-230p8rsf	140	15	the	the	DT
cord-269011-230p8rsf	140	16	first	first	JJ
cord-269011-230p8rsf	140	17	of	of	IN
cord-269011-230p8rsf	140	18	the	the	DT
cord-269011-230p8rsf	140	19	two	two	CD
cord-269011-230p8rsf	140	20	basic	basic	JJ
cord-269011-230p8rsf	140	21	regions	region	NNS
cord-269011-230p8rsf	140	22	is	be	VBZ
cord-269011-230p8rsf	140	23	notable	notable	JJ
cord-269011-230p8rsf	140	24	.	.	.
cord-269011-230p8rsf	141	1	Little	little	JJ
cord-269011-230p8rsf	141	2	is	be	VBZ
cord-269011-230p8rsf	141	3	known	know	VBN
cord-269011-230p8rsf	141	4	about	about	IN
cord-269011-230p8rsf	141	5	the	the	DT
cord-269011-230p8rsf	141	6	three	three	CD
cord-269011-230p8rsf	141	7	-	-	HYPH
cord-269011-230p8rsf	141	8	dimensional	dimensional	JJ
cord-269011-230p8rsf	141	9	structure	structure	NN
cord-269011-230p8rsf	141	10	of	of	IN
cord-269011-230p8rsf	141	11	the	the	DT
cord-269011-230p8rsf	141	12	N	N	NNP
cord-269011-230p8rsf	141	13	protein	protein	NN
cord-269011-230p8rsf	141	14	.	.	.
cord-269011-230p8rsf	142	1	Of	of	IN
cord-269011-230p8rsf	142	2	the	the	DT
cord-269011-230p8rsf	142	3	SARS	SARS	NNP
cord-269011-230p8rsf	142	4	-	-	HYPH
cord-269011-230p8rsf	142	5	CoV	CoV	NNP
cord-269011-230p8rsf	142	6	N	n	CD
cord-269011-230p8rsf	142	7	protein	protein	NN
cord-269011-230p8rsf	142	8	the	the	DT
cord-269011-230p8rsf	142	9	amino	amino	NN
cord-269011-230p8rsf	142	10	-	-	HYPH
cord-269011-230p8rsf	142	11	terminal	terminal	NN
cord-269011-230p8rsf	142	12	domain	domain	NN
cord-269011-230p8rsf	142	13	(	(	-LRB-
cord-269011-230p8rsf	142	14	residues	residue	NNS
cord-269011-230p8rsf	142	15	45	45	CD
cord-269011-230p8rsf	142	16	-	-	SYM
cord-269011-230p8rsf	142	17	181	181	CD
cord-269011-230p8rsf	142	18	)	)	-RRB-
cord-269011-230p8rsf	142	19	was	be	VBD
cord-269011-230p8rsf	142	20	analyzed	analyze	VBN
cord-269011-230p8rsf	142	21	by	by	IN
cord-269011-230p8rsf	142	22	nuclear	nuclear	JJ
cord-269011-230p8rsf	142	23	magnetic	magnetic	JJ
cord-269011-230p8rsf	142	24	resonance	resonance	NN
cord-269011-230p8rsf	142	25	spectroscopy	spectroscopy	NN
cord-269011-230p8rsf	142	26	.	.	.
cord-269011-230p8rsf	143	1	It	-PRON-	PRP
cord-269011-230p8rsf	143	2	appeared	appear	VBD
cord-269011-230p8rsf	143	3	to	to	TO
cord-269011-230p8rsf	143	4	consist	consist	VB
cord-269011-230p8rsf	143	5	of	of	IN
cord-269011-230p8rsf	143	6	a	a	DT
cord-269011-230p8rsf	143	7	five	five	CD
cord-269011-230p8rsf	143	8	-	-	HYPH
cord-269011-230p8rsf	143	9	stranded	stranded	JJ
cord-269011-230p8rsf	143	10	b	b	NN
cord-269011-230p8rsf	143	11	sheet	sheet	NN
cord-269011-230p8rsf	143	12	with	with	IN
cord-269011-230p8rsf	143	13	a	a	DT
cord-269011-230p8rsf	143	14	folding	folding	NN
cord-269011-230p8rsf	143	15	distinct	distinct	JJ
cord-269011-230p8rsf	143	16	from	from	IN
cord-269011-230p8rsf	143	17	that	that	DT
cord-269011-230p8rsf	143	18	of	of	IN
cord-269011-230p8rsf	143	19	other	other	JJ
cord-269011-230p8rsf	143	20	RNA	RNA	NNP
cord-269011-230p8rsf	143	21	-	-	HYPH
cord-269011-230p8rsf	143	22	binding	bind	VBG
cord-269011-230p8rsf	143	23	proteins	protein	NNS
cord-269011-230p8rsf	144	1	(	(	-LRB-
cord-269011-230p8rsf	144	2	Huang	Huang	NNP
cord-269011-230p8rsf	144	3	et	et	NNP
cord-269011-230p8rsf	144	4	al	al	NNP
cord-269011-230p8rsf	144	5	.	.	NNP
cord-269011-230p8rsf	144	6	,	,	,
cord-269011-230p8rsf	144	7	2004	2004	CD
cord-269011-230p8rsf	144	8	)	)	-RRB-
cord-269011-230p8rsf	144	9	.	.	.
cord-269011-230p8rsf	145	1	In	in	IN
cord-269011-230p8rsf	145	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	145	3	-	-	HYPH
cord-269011-230p8rsf	145	4	infected	infect	VBN
cord-269011-230p8rsf	145	5	cells	cell	NNS
cord-269011-230p8rsf	145	6	the	the	DT
cord-269011-230p8rsf	145	7	N	n	CD
cord-269011-230p8rsf	145	8	protein	protein	NN
cord-269011-230p8rsf	145	9	can	can	MD
cord-269011-230p8rsf	145	10	often	often	RB
cord-269011-230p8rsf	145	11	be	be	VB
cord-269011-230p8rsf	145	12	detected	detect	VBN
cord-269011-230p8rsf	145	13	as	as	IN
cord-269011-230p8rsf	145	14	one	one	CD
cord-269011-230p8rsf	145	15	major	major	JJ
cord-269011-230p8rsf	145	16	and	and	CC
cord-269011-230p8rsf	145	17	several	several	JJ
cord-269011-230p8rsf	145	18	minor	minor	JJ
cord-269011-230p8rsf	145	19	forms	form	NNS
cord-269011-230p8rsf	145	20	,	,	,
cord-269011-230p8rsf	145	21	the	the	DT
cord-269011-230p8rsf	145	22	latter	latter	JJ
cord-269011-230p8rsf	145	23	polypeptides	polypeptide	NNS
cord-269011-230p8rsf	145	24	having	have	VBG
cord-269011-230p8rsf	145	25	a	a	DT
cord-269011-230p8rsf	145	26	slightly	slightly	RB
cord-269011-230p8rsf	145	27	lower	low	JJR
cord-269011-230p8rsf	145	28	molecular	molecular	JJ
cord-269011-230p8rsf	145	29	weight	weight	NN
cord-269011-230p8rsf	145	30	.	.	.
cord-269011-230p8rsf	146	1	The	the	DT
cord-269011-230p8rsf	146	2	major	major	JJ
cord-269011-230p8rsf	146	3	species	specie	NNS
cord-269011-230p8rsf	146	4	appeared	appear	VBD
cord-269011-230p8rsf	146	5	to	to	IN
cord-269011-230p8rsf	146	6	comigrate	comigrate	NNP
cord-269011-230p8rsf	146	7	in	in	IN
cord-269011-230p8rsf	146	8	gels	gel	NNS
cord-269011-230p8rsf	146	9	with	with	IN
cord-269011-230p8rsf	146	10	the	the	DT
cord-269011-230p8rsf	146	11	N	N	NNP
cord-269011-230p8rsf	146	12	protein	protein	NN
cord-269011-230p8rsf	146	13	observed	observe	VBD
cord-269011-230p8rsf	146	14	in	in	IN
cord-269011-230p8rsf	146	15	virions	virion	NNS
cord-269011-230p8rsf	146	16	,	,	,
cord-269011-230p8rsf	146	17	indicating	indicate	VBG
cord-269011-230p8rsf	146	18	that	that	IN
cord-269011-230p8rsf	146	19	only	only	RB
cord-269011-230p8rsf	146	20	the	the	DT
cord-269011-230p8rsf	146	21	full	full	JJ
cord-269011-230p8rsf	146	22	-	-	HYPH
cord-269011-230p8rsf	146	23	len	len	NN
cord-269011-230p8rsf	146	24	gth	gth	NNP
cord-269011-230p8rsf	146	25	N	N	NNP
cord-269011-230p8rsf	146	26	spec	spec	NN
cord-269011-230p8rsf	146	27	ies	ie	NNS
cord-269011-230p8rsf	146	28	is	be	VBZ
cord-269011-230p8rsf	146	29	incorp	incorp	NNP
cord-269011-230p8rsf	146	30	orated	orate	VBN
cord-269011-230p8rsf	146	31	in	in	RP
cord-269011-230p8rsf	146	32	to	to	IN
cord-269011-230p8rsf	146	33	partic	partic	NNP
cord-269011-230p8rsf	146	34	les	les	NNP
cord-269011-230p8rsf	146	35	.	.	.
cord-269011-230p8rsf	147	1	How	how	WRB
cord-269011-230p8rsf	147	2	th	th	XX
cord-269011-230p8rsf	147	3	e	e	NN
cord-269011-230p8rsf	147	4	minor	minor	JJ
cord-269011-230p8rsf	147	5	N	n	CD
cord-269011-230p8rsf	147	6	spec	spec	NN
cord-269011-230p8rsf	147	7	ies	ie	NNS
cord-269011-230p8rsf	148	1	ar	ar	NNP
cord-269011-230p8rsf	148	2	ise	ise	NNP
cord-269011-230p8rsf	148	3	and	and	CC
cord-269011-230p8rsf	148	4	whet	whet	VB
cord-269011-230p8rsf	148	5	her	-PRON-	PRP
cord-269011-230p8rsf	149	1	they	-PRON-	PRP
cord-269011-230p8rsf	149	2	are	be	VBP
cord-269011-230p8rsf	149	3	of	of	IN
cord-269011-230p8rsf	149	4	partic	partic	JJ
cord-269011-230p8rsf	149	5	ular	ular	JJ
cord-269011-230p8rsf	149	6	significan	significan	FW
cord-269011-230p8rsf	149	7	ce	ce	NN
cord-269011-230p8rsf	149	8	for	for	IN
cord-269011-230p8rsf	149	9	infection	infection	NN
cord-269011-230p8rsf	150	1	is	be	VBZ
cord-269011-230p8rsf	150	2	unc	unc	NNP
cord-269011-230p8rsf	150	3	lear	lear	NNP
cord-269011-230p8rsf	150	4	.	.	.
cord-269011-230p8rsf	151	1	They	-PRON-	PRP
cord-269011-230p8rsf	151	2	are	be	VBP
cord-269011-230p8rsf	151	3	most	most	RBS
cord-269011-230p8rsf	151	4	likely	likely	RB
cord-269011-230p8rsf	151	5	derived	derive	VBN
cord-269011-230p8rsf	151	6	by	by	IN
cord-269011-230p8rsf	151	7	proteoly	proteoly	NNP
cord-269011-230p8rsf	151	8	tic	tic	NNP
cord-269011-230p8rsf	151	9	proc	proc	NNP
cord-269011-230p8rsf	151	10	essing	esse	VBG
cord-269011-230p8rsf	151	11	from	from	IN
cord-269011-230p8rsf	151	12	the	the	DT
cord-269011-230p8rsf	151	13	major	major	JJ
cord-269011-230p8rsf	151	14	N	n	CD
cord-269011-230p8rsf	151	15	species	specie	NNS
cord-269011-230p8rsf	151	16	.	.	.
cord-269011-230p8rsf	152	1	This	this	DT
cord-269011-230p8rsf	152	2	is	be	VBZ
cord-269011-230p8rsf	152	3	supp	supp	NN
cord-269011-230p8rsf	152	4	orted	orte	VBN
cord-269011-230p8rsf	152	5	by	by	IN
cord-269011-230p8rsf	152	6	stud	stud	NN
cord-269011-230p8rsf	152	7	ies	ie	NNS
cord-269011-230p8rsf	152	8	from	from	IN
cord-269011-230p8rsf	152	9	Eleo	Eleo	NNP
cord-269011-230p8rsf	152	10	uet	uet	NNP
cord-269011-230p8rsf	152	11	et	et	FW
cord-269011-230p8rsf	152	12	al	al	NNP
cord-269011-230p8rsf	152	13	.	.	.
cord-269011-230p8rsf	153	1	(	(	-LRB-
cord-269011-230p8rsf	153	2	2000	2000	CD
cord-269011-230p8rsf	153	3	)	)	-RRB-
cord-269011-230p8rsf	153	4	,	,	,
cord-269011-230p8rsf	153	5	who	who	WP
cord-269011-230p8rsf	153	6	show	show	VBP
cord-269011-230p8rsf	153	7	ed	ed	NNP
cord-269011-230p8rsf	153	8	the	the	DT
cord-269011-230p8rsf	153	9	TGE	TGE	NNP
cord-269011-230p8rsf	153	10	V	V	NNP
cord-269011-230p8rsf	153	11	N	n	NN
cord-269011-230p8rsf	153	12	prot	prot	NN
cord-269011-230p8rsf	153	13	ein	ein	NNP
cord-269011-230p8rsf	153	14	to	to	TO
cord-269011-230p8rsf	153	15	be	be	VB
cord-269011-230p8rsf	153	16	cleav	cleav	NNP
cord-269011-230p8rsf	153	17	ed	ed	NNP
cord-269011-230p8rsf	153	18	by	by	IN
cord-269011-230p8rsf	153	19	casp	casp	NNP
cord-269011-230p8rsf	153	20	ases	ases	NNP
cord-269011-230p8rsf	153	21	.	.	.
cord-269011-230p8rsf	154	1	Cas	Cas	NNP
cord-269011-230p8rsf	154	2	pase	pase	NNP
cord-269011-230p8rsf	154	3	cleava	cleava	NNP
cord-269011-230p8rsf	154	4	ge	ge	NNP
cord-269011-230p8rsf	154	5	sites	sites	NNP
cord-269011-230p8rsf	155	1	wer	wer	NNP
cord-269011-230p8rsf	155	2	e	e	NNP
cord-269011-230p8rsf	155	3	also	also	RB
cord-269011-230p8rsf	155	4	predicted	predict	VBD
cord-269011-230p8rsf	155	5	in	in	IN
cord-269011-230p8rsf	155	6	the	the	DT
cord-269011-230p8rsf	155	7	carboxy	carboxy	JJ
cord-269011-230p8rsf	155	8	terminus	terminus	NN
cord-269011-230p8rsf	155	9	of	of	IN
cord-269011-230p8rsf	155	10	several	several	JJ
cord-269011-230p8rsf	155	11	other	other	JJ
cord-269011-230p8rsf	155	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	155	13	N	n	CD
cord-269011-230p8rsf	155	14	proteins	protein	NNS
cord-269011-230p8rsf	156	1	(	(	-LRB-
cord-269011-230p8rsf	156	2	Eleouet	Eleouet	NNP
cord-269011-230p8rsf	156	3	et	et	NNP
cord-269011-230p8rsf	156	4	al	al	NNP
cord-269011-230p8rsf	156	5	.	.	NNP
cord-269011-230p8rsf	156	6	,	,	,
cord-269011-230p8rsf	156	7	2000	2000	CD
cord-269011-230p8rsf	156	8	;	;	:
cord-269011-230p8rsf	156	9	Ying	Ying	NNP
cord-269011-230p8rsf	156	10	et	et	FW
cord-269011-230p8rsf	156	11	al	al	NNP
cord-269011-230p8rsf	156	12	.	.	NNP
cord-269011-230p8rsf	156	13	,	,	,
cord-269011-230p8rsf	156	14	2004	2004	CD
cord-269011-230p8rsf	156	15	)	)	-RRB-
cord-269011-230p8rsf	156	16	.	.	.
cord-269011-230p8rsf	157	1	These	these	DT
cord-269011-230p8rsf	157	2	features	feature	NNS
cord-269011-230p8rsf	157	3	are	be	VBP
cord-269011-230p8rsf	157	4	in	in	IN
cord-269011-230p8rsf	157	5	agreement	agreement	NN
cord-269011-230p8rsf	157	6	with	with	IN
cord-269011-230p8rsf	157	7	observations	observation	NNS
cord-269011-230p8rsf	157	8	showing	show	VBG
cord-269011-230p8rsf	157	9	that	that	IN
cord-269011-230p8rsf	157	10	antibodies	antibody	NNS
cord-269011-230p8rsf	157	11	directed	direct	VBN
cord-269011-230p8rsf	157	12	against	against	IN
cord-269011-230p8rsf	157	13	the	the	DT
cord-269011-230p8rsf	157	14	carboxy	carboxy	JJ
cord-269011-230p8rsf	157	15	terminus	terminus	NN
cord-269011-230p8rsf	157	16	of	of	IN
cord-269011-230p8rsf	157	17	the	the	DT
cord-269011-230p8rsf	157	18	MHV	MHV	NNP
cord-269011-230p8rsf	157	19	and	and	CC
cord-269011-230p8rsf	157	20	TGEV	TGEV	NNP
cord-269011-230p8rsf	157	21	N	n	CD
cord-269011-230p8rsf	157	22	proteins	protein	NNS
cord-269011-230p8rsf	157	23	were	be	VBD
cord-269011-230p8rsf	157	24	not	not	RB
cord-269011-230p8rsf	157	25	reactive	reactive	JJ
cord-269011-230p8rsf	157	26	with	with	IN
cord-269011-230p8rsf	157	27	the	the	DT
cord-269011-230p8rsf	157	28	faster	fast	RBR
cord-269011-230p8rsf	157	29	migrating	migrate	VBG
cord-269011-230p8rsf	157	30	electrophoretic	electrophoretic	JJ
cord-269011-230p8rsf	157	31	forms	form	NNS
cord-269011-230p8rsf	157	32	.	.	.
cord-269011-230p8rsf	158	1	Furthermore	furthermore	RB
cord-269011-230p8rsf	158	2	,	,	,
cord-269011-230p8rsf	158	3	these	these	DT
cord-269011-230p8rsf	158	4	smaller	small	JJR
cord-269011-230p8rsf	158	5	N	N	NNP
cord-269011-230p8rsf	158	6	protein	protein	NN
cord-269011-230p8rsf	158	7	forms	form	NNS
cord-269011-230p8rsf	158	8	appeared	appear	VBD
cord-269011-230p8rsf	158	9	to	to	TO
cord-269011-230p8rsf	158	10	be	be	VB
cord-269011-230p8rsf	158	11	derived	derive	VBN
cord-269011-230p8rsf	158	12	from	from	IN
cord-269011-230p8rsf	158	13	the	the	DT
cord-269011-230p8rsf	158	14	major	major	JJ
cord-269011-230p8rsf	158	15	species	specie	NNS
cord-269011-230p8rsf	158	16	as	as	IN
cord-269011-230p8rsf	158	17	judged	judge	VBN
cord-269011-230p8rsf	158	18	from	from	IN
cord-269011-230p8rsf	158	19	pulse	pulse	NN
cord-269011-230p8rsf	158	20	-	-	HYPH
cord-269011-230p8rsf	158	21	chase	chase	NN
cord-269011-230p8rsf	158	22	analyses	analysis	NNS
cord-269011-230p8rsf	158	23	(	(	-LRB-
cord-269011-230p8rsf	158	24	for	for	IN
cord-269011-230p8rsf	158	25	a	a	DT
cord-269011-230p8rsf	158	26	review	review	NN
cord-269011-230p8rsf	158	27	see	see	VB
cord-269011-230p8rsf	158	28	Laude	Laude	NNP
cord-269011-230p8rsf	158	29	and	and	CC
cord-269011-230p8rsf	158	30	Masters	Masters	NNPS
cord-269011-230p8rsf	158	31	,	,	,
cord-269011-230p8rsf	158	32	1995	1995	CD
cord-269011-230p8rsf	158	33	)	)	-RRB-
cord-269011-230p8rsf	158	34	.	.	.
cord-269011-230p8rsf	159	1	The	the	DT
cord-269011-230p8rsf	159	2	N	N	NNP
cord-269011-230p8rsf	159	3	protein	protein	NN
cord-269011-230p8rsf	159	4	is	be	VBZ
cord-269011-230p8rsf	159	5	the	the	DT
cord-269011-230p8rsf	159	6	only	only	JJ
cord-269011-230p8rsf	159	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	159	8	structural	structural	JJ
cord-269011-230p8rsf	159	9	protein	protein	NN
cord-269011-230p8rsf	159	10	known	know	VBN
cord-269011-230p8rsf	159	11	to	to	TO
cord-269011-230p8rsf	159	12	become	become	VB
cord-269011-230p8rsf	159	13	phosphorylated	phosphorylated	JJ
cord-269011-230p8rsf	159	14	(	(	-LRB-
cord-269011-230p8rsf	159	15	for	for	IN
cord-269011-230p8rsf	159	16	references	reference	NNS
cord-269011-230p8rsf	159	17	see	see	VBP
cord-269011-230p8rsf	159	18	Laude	Laude	NNP
cord-269011-230p8rsf	159	19	and	and	CC
cord-269011-230p8rsf	159	20	Masters	Masters	NNPS
cord-269011-230p8rsf	159	21	,	,	,
cord-269011-230p8rsf	159	22	1995	1995	CD
cord-269011-230p8rsf	159	23	)	)	-RRB-
cord-269011-230p8rsf	159	24	.	.	.
cord-269011-230p8rsf	160	1	Both	both	DT
cord-269011-230p8rsf	160	2	the	the	DT
cord-269011-230p8rsf	160	3	major	major	JJ
cord-269011-230p8rsf	160	4	and	and	CC
cord-269011-230p8rsf	160	5	minor	minor	JJ
cord-269011-230p8rsf	160	6	N	n	CD
cord-269011-230p8rsf	160	7	species	specie	NNS
cord-269011-230p8rsf	160	8	appear	appear	VBP
cord-269011-230p8rsf	160	9	to	to	TO
cord-269011-230p8rsf	160	10	be	be	VB
cord-269011-230p8rsf	160	11	phosphorylated	phosphorylate	VBN
cord-269011-230p8rsf	160	12	as	as	IN
cord-269011-230p8rsf	160	13	shown	show	VBN
cord-269011-230p8rsf	160	14	for	for	IN
cord-269011-230p8rsf	160	15	MHV	MHV	NNP
cord-269011-230p8rsf	160	16	-	-	HYPH
cord-269011-230p8rsf	160	17	A59	A59	NNP
cord-269011-230p8rsf	160	18	in	in	IN
cord-269011-230p8rsf	160	19	Sac(À	Sac(À	NNP
cord-269011-230p8rsf	160	20	)	)	-RRB-
cord-269011-230p8rsf	160	21	cells	cell	NNS
cord-269011-230p8rsf	161	1	(	(	-LRB-
cord-269011-230p8rsf	161	2	Rottier	Rottier	NNP
cord-269011-230p8rsf	161	3	et	et	NNP
cord-269011-230p8rsf	161	4	al	al	NNP
cord-269011-230p8rsf	161	5	.	.	NNP
cord-269011-230p8rsf	161	6	,	,	,
cord-269011-230p8rsf	161	7	1981b	1981b	CD
cord-269011-230p8rsf	161	8	)	)	-RRB-
cord-269011-230p8rsf	161	9	and	and	CC
cord-269011-230p8rsf	161	10	for	for	IN
cord-269011-230p8rsf	161	11	TGEV	TGEV	NNP
cord-269011-230p8rsf	161	12	in	in	IN
cord-269011-230p8rsf	161	13	LLC	LLC	NNP
cord-269011-230p8rsf	161	14	-	-	HYPH
cord-269011-230p8rsf	161	15	PK1	PK1	NNP
cord-269011-230p8rsf	161	16	cells	cell	NNS
cord-269011-230p8rsf	162	1	(	(	-LRB-
cord-269011-230p8rsf	162	2	Garwes	Garwes	NNP
cord-269011-230p8rsf	162	3	et	et	FW
cord-269011-230p8rsf	162	4	al	al	NNP
cord-269011-230p8rsf	162	5	.	.	NNP
cord-269011-230p8rsf	162	6	,	,	,
cord-269011-230p8rsf	162	7	1984	1984	CD
cord-269011-230p8rsf	162	8	)	)	-RRB-
cord-269011-230p8rsf	162	9	.	.	.
cord-269011-230p8rsf	163	1	Of	of	IN
cord-269011-230p8rsf	163	2	the	the	DT
cord-269011-230p8rsf	163	3	many	many	JJ
cord-269011-230p8rsf	163	4	potential	potential	JJ
cord-269011-230p8rsf	163	5	target	target	NN
cord-269011-230p8rsf	163	6	serines	serine	NNS
cord-269011-230p8rsf	163	7	only	only	RB
cord-269011-230p8rsf	163	8	a	a	DT
cord-269011-230p8rsf	163	9	few	few	JJ
cord-269011-230p8rsf	163	10	are	be	VBP
cord-269011-230p8rsf	163	11	actually	actually	RB
cord-269011-230p8rsf	163	12	modified	modify	VBN
cord-269011-230p8rsf	163	13	in	in	IN
cord-269011-230p8rsf	163	14	the	the	DT
cord-269011-230p8rsf	163	15	case	case	NN
cord-269011-230p8rsf	163	16	of	of	IN
cord-269011-230p8rsf	163	17	MHV	MHV	NNP
cord-269011-230p8rsf	163	18	(	(	-LRB-
cord-269011-230p8rsf	163	19	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	163	20	and	and	CC
cord-269011-230p8rsf	163	21	Lai	Lai	NNP
cord-269011-230p8rsf	163	22	,	,	,
cord-269011-230p8rsf	163	23	1979	1979	CD
cord-269011-230p8rsf	163	24	;	;	:
cord-269011-230p8rsf	163	25	Wilbur	Wilbur	NNP
cord-269011-230p8rsf	163	26	et	et	NNP
cord-269011-230p8rsf	163	27	al	al	NNP
cord-269011-230p8rsf	163	28	.	.	NNP
cord-269011-230p8rsf	163	29	,	,	,
cord-269011-230p8rsf	163	30	1986	1986	CD
cord-269011-230p8rsf	163	31	)	)	-RRB-
cord-269011-230p8rsf	163	32	.	.	.
cord-269011-230p8rsf	164	1	N	n	NN
cord-269011-230p8rsf	164	2	protein	protein	NN
cord-269011-230p8rsf	164	3	phosphorylation	phosphorylation	NN
cord-269011-230p8rsf	164	4	does	do	VBZ
cord-269011-230p8rsf	164	5	not	not	RB
cord-269011-230p8rsf	164	6	seem	seem	VB
cord-269011-230p8rsf	164	7	to	to	TO
cord-269011-230p8rsf	164	8	play	play	VB
cord-269011-230p8rsf	164	9	a	a	DT
cord-269011-230p8rsf	164	10	critical	critical	JJ
cord-269011-230p8rsf	164	11	role	role	NN
cord-269011-230p8rsf	164	12	in	in	IN
cord-269011-230p8rsf	164	13	the	the	DT
cord-269011-230p8rsf	164	14	regulation	regulation	NN
cord-269011-230p8rsf	164	15	of	of	IN
cord-269011-230p8rsf	164	16	virus	virus	NN
cord-269011-230p8rsf	164	17	assembly	assembly	NN
cord-269011-230p8rsf	164	18	.	.	.
cord-269011-230p8rsf	165	1	In	in	IN
cord-269011-230p8rsf	165	2	contrast	contrast	NN
cord-269011-230p8rsf	165	3	,	,	,
cord-269011-230p8rsf	165	4	it	-PRON-	PRP
cord-269011-230p8rsf	165	5	has	have	VBZ
cord-269011-230p8rsf	165	6	been	be	VBN
cord-269011-230p8rsf	165	7	hypothesized	hypothesize	VBN
cord-269011-230p8rsf	165	8	that	that	IN
cord-269011-230p8rsf	165	9	dephosphorylation	dephosphorylation	NN
cord-269011-230p8rsf	165	10	of	of	IN
cord-269011-230p8rsf	165	11	the	the	DT
cord-269011-230p8rsf	165	12	protein	protein	NN
cord-269011-230p8rsf	165	13	might	may	MD
cord-269011-230p8rsf	165	14	facilitate	facilitate	VB
cord-269011-230p8rsf	165	15	disassembly	disassembly	NN
cord-269011-230p8rsf	165	16	during	during	IN
cord-269011-230p8rsf	165	17	MHV	MHV	NNP
cord-269011-230p8rsf	165	18	cell	cell	NN
cord-269011-230p8rsf	165	19	entry	entry	NN
cord-269011-230p8rsf	165	20	(	(	-LRB-
cord-269011-230p8rsf	165	21	Kalicharran	Kalicharran	NNP
cord-269011-230p8rsf	165	22	et	et	FW
cord-269011-230p8rsf	165	23	al	al	NNP
cord-269011-230p8rsf	165	24	.	.	NNP
cord-269011-230p8rsf	165	25	,	,	,
cord-269011-230p8rsf	165	26	1996	1996	CD
cord-269011-230p8rsf	165	27	;	;	:
cord-269011-230p8rsf	165	28	Mohandas	Mohandas	NNP
cord-269011-230p8rsf	165	29	and	and	CC
cord-269011-230p8rsf	165	30	Dales	Dales	NNP
cord-269011-230p8rsf	165	31	,	,	,
cord-269011-230p8rsf	165	32	1991	1991	CD
cord-269011-230p8rsf	165	33	)	)	-RRB-
cord-269011-230p8rsf	165	34	.	.	.
cord-269011-230p8rsf	166	1	Immunofluorescence	immunofluorescence	NN
cord-269011-230p8rsf	166	2	microscopy	microscopy	NN
cord-269011-230p8rsf	166	3	has	have	VBZ
cord-269011-230p8rsf	166	4	shown	show	VBN
cord-269011-230p8rsf	166	5	the	the	DT
cord-269011-230p8rsf	166	6	N	n	CD
cord-269011-230p8rsf	166	7	protein	protein	NN
cord-269011-230p8rsf	166	8	to	to	TO
cord-269011-230p8rsf	166	9	be	be	VB
cord-269011-230p8rsf	166	10	localized	localize	VBN
cord-269011-230p8rsf	166	11	in	in	IN
cord-269011-230p8rsf	166	12	a	a	DT
cord-269011-230p8rsf	166	13	particulate	particulate	NN
cord-269011-230p8rsf	166	14	manner	manner	NN
cord-269011-230p8rsf	166	15	throughout	throughout	IN
cord-269011-230p8rsf	166	16	the	the	DT
cord-269011-230p8rsf	166	17	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	166	18	of	of	IN
cord-269011-230p8rsf	166	19	coronavirus	coronavirus	NN
cord-269011-230p8rsf	166	20	-	-	HYPH
cord-269011-230p8rsf	166	21	infected	infect	VBN
cord-269011-230p8rsf	166	22	cells	cell	NNS
cord-269011-230p8rsf	166	23	.	.	.
cord-269011-230p8rsf	167	1	Although	although	IN
cord-269011-230p8rsf	167	2	the	the	DT
cord-269011-230p8rsf	167	3	protein	protein	NN
cord-269011-230p8rsf	167	4	lacks	lack	VBZ
cord-269011-230p8rsf	167	5	a	a	DT
cord-269011-230p8rsf	167	6	membrane	membrane	NN
cord-269011-230p8rsf	167	7	-	-	HYPH
cord-269011-230p8rsf	167	8	spanning	span	VBG
cord-269011-230p8rsf	167	9	domain	domain	NN
cord-269011-230p8rsf	167	10	it	-PRON-	PRP
cord-269011-230p8rsf	167	11	was	be	VBD
cord-269011-230p8rsf	167	12	found	find	VBN
cord-269011-230p8rsf	167	13	in	in	IN
cord-269011-230p8rsf	167	14	association	association	NN
cord-269011-230p8rsf	167	15	with	with	IN
cord-269011-230p8rsf	167	16	membranes	membrane	NNS
cord-269011-230p8rsf	167	17	(	(	-LRB-
cord-269011-230p8rsf	167	18	Anderson	Anderson	NNP
cord-269011-230p8rsf	167	19	and	and	CC
cord-269011-230p8rsf	167	20	Wong	Wong	NNP
cord-269011-230p8rsf	167	21	,	,	,
cord-269011-230p8rsf	167	22	1993	1993	CD
cord-269011-230p8rsf	167	23	;	;	:
cord-269011-230p8rsf	167	24	Sims	Sims	NNP
cord-269011-230p8rsf	167	25	et	et	NNP
cord-269011-230p8rsf	167	26	al	al	NNP
cord-269011-230p8rsf	167	27	.	.	NNP
cord-269011-230p8rsf	167	28	,	,	,
cord-269011-230p8rsf	167	29	2000	2000	CD
cord-269011-230p8rsf	167	30	;	;	:
cord-269011-230p8rsf	167	31	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	167	32	et	et	NNP
cord-269011-230p8rsf	167	33	al	al	NNP
cord-269011-230p8rsf	167	34	.	.	NNP
cord-269011-230p8rsf	167	35	,	,	,
cord-269011-230p8rsf	167	36	1983	1983	CD
cord-269011-230p8rsf	167	37	)	)	-RRB-
cord-269011-230p8rsf	167	38	.	.	.
cord-269011-230p8rsf	168	1	For	for	IN
cord-269011-230p8rsf	168	2	MHV	MHV	NNP
cord-269011-230p8rsf	168	3	,	,	,
cord-269011-230p8rsf	168	4	the	the	DT
cord-269011-230p8rsf	168	5	N	N	NNP
cord-269011-230p8rsf	168	6	protein	protein	NN
cord-269011-230p8rsf	168	7	was	be	VBD
cord-269011-230p8rsf	168	8	found	find	VBN
cord-269011-230p8rsf	168	9	to	to	TO
cord-269011-230p8rsf	168	10	colocalize	colocalize	VB
cord-269011-230p8rsf	168	11	partly	partly	RB
cord-269011-230p8rsf	168	12	with	with	IN
cord-269011-230p8rsf	168	13	the	the	DT
cord-269011-230p8rsf	168	14	membrane	membrane	NN
cord-269011-230p8rsf	168	15	-	-	HYPH
cord-269011-230p8rsf	168	16	associated	associate	VBN
cord-269011-230p8rsf	168	17	viral	viral	JJ
cord-269011-230p8rsf	168	18	replication	replication	NN
cord-269011-230p8rsf	168	19	complexes	complex	NNS
cord-269011-230p8rsf	168	20	van	van	NNP
cord-269011-230p8rsf	168	21	der	der	NNP
cord-269011-230p8rsf	168	22	Meer	Meer	NNP
cord-269011-230p8rsf	168	23	et	et	NNP
cord-269011-230p8rsf	168	24	al	al	NNP
cord-269011-230p8rsf	168	25	.	.	NNP
cord-269011-230p8rsf	168	26	,	,	,
cord-269011-230p8rsf	168	27	1999	1999	CD
cord-269011-230p8rsf	168	28	)	)	-RRB-
cord-269011-230p8rsf	168	29	.	.	.
cord-269011-230p8rsf	169	1	In	in	IN
cord-269011-230p8rsf	169	2	addition	addition	NN
cord-269011-230p8rsf	169	3	to	to	IN
cord-269011-230p8rsf	169	4	its	-PRON-	PRP$
cord-269011-230p8rsf	169	5	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	169	6	localization	localization	NN
cord-269011-230p8rsf	169	7	,	,	,
cord-269011-230p8rsf	169	8	the	the	DT
cord-269011-230p8rsf	169	9	N	n	CD
cord-269011-230p8rsf	169	10	proteins	protein	NNS
cord-269011-230p8rsf	169	11	of	of	IN
cord-269011-230p8rsf	169	12	IBV	IBV	NNP
cord-269011-230p8rsf	169	13	,	,	,
cord-269011-230p8rsf	169	14	MHV	MHV	NNP
cord-269011-230p8rsf	169	15	,	,	,
cord-269011-230p8rsf	169	16	and	and	CC
cord-269011-230p8rsf	169	17	TGEV	TGEV	NNP
cord-269011-230p8rsf	169	18	have	have	VBP
cord-269011-230p8rsf	169	19	also	also	RB
cord-269011-230p8rsf	169	20	been	be	VBN
cord-269011-230p8rsf	169	21	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	169	22	to	to	TO
cord-269011-230p8rsf	169	23	localize	localize	VB
cord-269011-230p8rsf	169	24	to	to	IN
cord-269011-230p8rsf	169	25	the	the	DT
cord-269011-230p8rsf	169	26	nucleolus	nucleolus	NN
cord-269011-230p8rsf	169	27	both	both	CC
cord-269011-230p8rsf	169	28	in	in	IN
cord-269011-230p8rsf	169	29	coronavirus	coronavirus	NN
cord-269011-230p8rsf	169	30	-	-	HYPH
cord-269011-230p8rsf	169	31	infected	infect	VBN
cord-269011-230p8rsf	169	32	cells	cell	NNS
cord-269011-230p8rsf	169	33	and	and	CC
cord-269011-230p8rsf	169	34	when	when	WRB
cord-269011-230p8rsf	169	35	expressed	express	VBN
cord-269011-230p8rsf	169	36	independently	independently	RB
cord-269011-230p8rsf	169	37	Wurm	Wurm	NNP
cord-269011-230p8rsf	169	38	et	et	NNP
cord-269011-230p8rsf	169	39	al	al	NNP
cord-269011-230p8rsf	169	40	.	.	NNP
cord-269011-230p8rsf	169	41	,	,	,
cord-269011-230p8rsf	169	42	2001	2001	CD
cord-269011-230p8rsf	169	43	)	)	-RRB-
cord-269011-230p8rsf	169	44	.	.	.
cord-269011-230p8rsf	170	1	Putative	putative	JJ
cord-269011-230p8rsf	170	2	nuclear	nuclear	JJ
cord-269011-230p8rsf	170	3	localization	localization	NN
cord-269011-230p8rsf	170	4	signals	signal	NNS
cord-269011-230p8rsf	170	5	were	be	VBD
cord-269011-230p8rsf	170	6	identified	identify	VBN
cord-269011-230p8rsf	170	7	in	in	IN
cord-269011-230p8rsf	170	8	these	these	DT
cord-269011-230p8rsf	170	9	proteins	protein	NNS
cord-269011-230p8rsf	170	10	.	.	.
cord-269011-230p8rsf	171	1	The	the	DT
cord-269011-230p8rsf	171	2	IBV	IBV	NNP
cord-269011-230p8rsf	171	3	N	N	NNP
cord-269011-230p8rsf	171	4	protein	protein	NN
cord-269011-230p8rsf	171	5	was	be	VBD
cord-269011-230p8rsf	171	6	found	find	VBN
cord-269011-230p8rsf	171	7	to	to	TO
cord-269011-230p8rsf	171	8	interact	interact	VB
cord-269011-230p8rsf	171	9	with	with	IN
cord-269011-230p8rsf	171	10	nucleolar	nucleolar	JJ
cord-269011-230p8rsf	171	11	antigens	antigen	NNS
cord-269011-230p8rsf	171	12	,	,	,
cord-269011-230p8rsf	171	13	which	which	WDT
cord-269011-230p8rsf	171	14	appeared	appear	VBD
cord-269011-230p8rsf	171	15	to	to	TO
cord-269011-230p8rsf	171	16	occur	occur	VB
cord-269011-230p8rsf	171	17	more	more	RBR
cord-269011-230p8rsf	171	18	efficiently	efficiently	RB
cord-269011-230p8rsf	171	19	when	when	WRB
cord-269011-230p8rsf	171	20	the	the	DT
cord-269011-230p8rsf	171	21	N	N	NNP
cord-269011-230p8rsf	171	22	protein	protein	NN
cord-269011-230p8rsf	171	23	was	be	VBD
cord-269011-230p8rsf	171	24	phosphorylated	phosphorylate	VBN
cord-269011-230p8rsf	171	25	,	,	,
cord-269011-230p8rsf	171	26	and	and	CC
cord-269011-230p8rsf	171	27	to	to	TO
cord-269011-230p8rsf	171	28	affect	affect	VB
cord-269011-230p8rsf	171	29	the	the	DT
cord-269011-230p8rsf	171	30	cell	cell	NN
cord-269011-230p8rsf	171	31	cycle	cycle	NN
cord-269011-230p8rsf	171	32	(	(	-LRB-
cord-269011-230p8rsf	171	33	Chen	Chen	NNP
cord-269011-230p8rsf	171	34	et	et	NNP
cord-269011-230p8rsf	171	35	al	al	NNP
cord-269011-230p8rsf	171	36	.	.	NNP
cord-269011-230p8rsf	171	37	,	,	,
cord-269011-230p8rsf	171	38	2002	2002	CD
cord-269011-230p8rsf	171	39	)	)	-RRB-
cord-269011-230p8rsf	171	40	.	.	.
cord-269011-230p8rsf	172	1	However	however	RB
cord-269011-230p8rsf	172	2	,	,	,
cord-269011-230p8rsf	172	3	because	because	IN
cord-269011-230p8rsf	172	4	MHV	MHV	NNP
cord-269011-230p8rsf	172	5	is	be	VBZ
cord-269011-230p8rsf	172	6	able	able	JJ
cord-269011-230p8rsf	172	7	to	to	TO
cord-269011-230p8rsf	172	8	replicate	replicate	VB
cord-269011-230p8rsf	172	9	in	in	IN
cord-269011-230p8rsf	172	10	enucleated	enucleated	JJ
cord-269011-230p8rsf	172	11	cells	cell	NNS
cord-269011-230p8rsf	172	12	(	(	-LRB-
cord-269011-230p8rsf	172	13	Brayton	Brayton	NNP
cord-269011-230p8rsf	172	14	et	et	NNP
cord-269011-230p8rsf	172	15	al	al	NNP
cord-269011-230p8rsf	172	16	.	.	NNP
cord-269011-230p8rsf	172	17	,	,	,
cord-269011-230p8rsf	172	18	1981	1981	CD
cord-269011-230p8rsf	172	19	;	;	:
cord-269011-230p8rsf	172	20	Wilhelmsen	Wilhelmsen	NNP
cord-269011-230p8rsf	172	21	et	et	NNP
cord-269011-230p8rsf	172	22	al	al	NNP
cord-269011-230p8rsf	172	23	.	.	NNP
cord-269011-230p8rsf	172	24	,	,	,
cord-269011-230p8rsf	172	25	1981	1981	CD
cord-269011-230p8rsf	172	26	)	)	-RRB-
cord-269011-230p8rsf	173	1	the	the	DT
cord-269011-230p8rsf	173	2	nucleolar	nucleolar	JJ
cord-269011-230p8rsf	173	3	localization	localization	NN
cord-269011-230p8rsf	173	4	of	of	IN
cord-269011-230p8rsf	173	5	the	the	DT
cord-269011-230p8rsf	173	6	N	N	NNP
cord-269011-230p8rsf	173	7	protein	protein	NN
cord-269011-230p8rsf	173	8	does	do	VBZ
cord-269011-230p8rsf	173	9	not	not	RB
cord-269011-230p8rsf	173	10	appear	appear	VB
cord-269011-230p8rsf	173	11	an	an	DT
cord-269011-230p8rsf	173	12	essential	essential	JJ
cord-269011-230p8rsf	173	13	step	step	NN
cord-269011-230p8rsf	173	14	during	during	IN
cord-269011-230p8rsf	173	15	infection	infection	NN
cord-269011-230p8rsf	173	16	.	.	.
cord-269011-230p8rsf	174	1	Although	although	IN
cord-269011-230p8rsf	174	2	the	the	DT
cord-269011-230p8rsf	174	3	primary	primary	JJ
cord-269011-230p8rsf	174	4	function	function	NN
cord-269011-230p8rsf	174	5	of	of	IN
cord-269011-230p8rsf	174	6	the	the	DT
cord-269011-230p8rsf	174	7	N	N	NNP
cord-269011-230p8rsf	174	8	protein	protein	NN
cord-269011-230p8rsf	174	9	is	be	VBZ
cord-269011-230p8rsf	174	10	the	the	DT
cord-269011-230p8rsf	174	11	formation	formation	NN
cord-269011-230p8rsf	174	12	of	of	IN
cord-269011-230p8rsf	174	13	the	the	DT
cord-269011-230p8rsf	174	14	viral	viral	JJ
cord-269011-230p8rsf	174	15	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	174	16	complex	complex	NN
cord-269011-230p8rsf	174	17	,	,	,
cord-269011-230p8rsf	174	18	several	several	JJ
cord-269011-230p8rsf	174	19	studies	study	NNS
cord-269011-230p8rsf	174	20	indicate	indicate	VBP
cord-269011-230p8rsf	174	21	the	the	DT
cord-269011-230p8rsf	174	22	protein	protein	NN
cord-269011-230p8rsf	174	23	to	to	TO
cord-269011-230p8rsf	174	24	be	be	VB
cord-269011-230p8rsf	174	25	multifunctional	multifunctional	JJ
cord-269011-230p8rsf	174	26	.	.	.
cord-269011-230p8rsf	175	1	As	as	IN
cord-269011-230p8rsf	175	2	indicated	indicate	VBN
cord-269011-230p8rsf	175	3	by	by	IN
cord-269011-230p8rsf	175	4	its	-PRON-	PRP$
cord-269011-230p8rsf	175	5	intracellular	intracellular	JJ
cord-269011-230p8rsf	175	6	localization	localization	NN
cord-269011-230p8rsf	175	7	,	,	,
cord-269011-230p8rsf	175	8	the	the	DT
cord-269011-230p8rsf	175	9	N	N	NNP
cord-269011-230p8rsf	175	10	protein	protein	NN
cord-269011-230p8rsf	175	11	is	be	VBZ
cord-269011-230p8rsf	175	12	a	a	DT
cord-269011-230p8rsf	175	13	likely	likely	JJ
cord-269011-230p8rsf	175	14	component	component	NN
cord-269011-230p8rsf	175	15	of	of	IN
cord-269011-230p8rsf	175	16	the	the	DT
cord-269011-230p8rsf	175	17	coronavirus	coronavirus	NN
cord-269011-230p8rsf	175	18	replication	replication	NN
cord-269011-230p8rsf	175	19	and	and	CC
cord-269011-230p8rsf	175	20	transcription	transcription	NN
cord-269011-230p8rsf	175	21	complex	complex	NN
cord-269011-230p8rsf	175	22	.	.	.
cord-269011-230p8rsf	176	1	Its	-PRON-	PRP$
cord-269011-230p8rsf	176	2	presence	presence	NN
cord-269011-230p8rsf	176	3	is	be	VBZ
cord-269011-230p8rsf	176	4	not	not	RB
cord-269011-230p8rsf	176	5	an	an	DT
cord-269011-230p8rsf	176	6	absolute	absolute	JJ
cord-269011-230p8rsf	176	7	requirement	requirement	NN
cord-269011-230p8rsf	176	8	for	for	IN
cord-269011-230p8rsf	176	9	replication	replication	NN
cord-269011-230p8rsf	176	10	and	and	CC
cord-269011-230p8rsf	176	11	transcription	transcription	NN
cord-269011-230p8rsf	176	12	because	because	IN
cord-269011-230p8rsf	176	13	a	a	DT
cord-269011-230p8rsf	176	14	human	human	JJ
cord-269011-230p8rsf	176	15	coronavirus	coronavirus	NN
cord-269011-230p8rsf	176	16	(	(	-LRB-
cord-269011-230p8rsf	176	17	HCoV	HCoV	NNP
cord-269011-230p8rsf	176	18	)	)	-RRB-
cord-269011-230p8rsf	176	19	RNA	rna	NN
cord-269011-230p8rsf	176	20	vector	vector	NN
cord-269011-230p8rsf	176	21	containing	contain	VBG
cord-269011-230p8rsf	176	22	the	the	DT
cord-269011-230p8rsf	176	23	complete	complete	JJ
cord-269011-230p8rsf	176	24	pol1ab	pol1ab	NNP
cord-269011-230p8rsf	176	25	gene	gene	NN
cord-269011-230p8rsf	176	26	appeared	appear	VBD
cord-269011-230p8rsf	176	27	to	to	TO
cord-269011-230p8rsf	176	28	be	be	VB
cord-269011-230p8rsf	176	29	functional	functional	JJ
cord-269011-230p8rsf	176	30	in	in	IN
cord-269011-230p8rsf	176	31	the	the	DT
cord-269011-230p8rsf	176	32	absence	absence	NN
cord-269011-230p8rsf	176	33	of	of	IN
cord-269011-230p8rsf	176	34	the	the	DT
cord-269011-230p8rsf	176	35	N	n	CD
cord-269011-230p8rsf	176	36	protein	protein	NN
cord-269011-230p8rsf	176	37	(	(	-LRB-
cord-269011-230p8rsf	176	38	Thiel	Thiel	NNP
cord-269011-230p8rsf	176	39	et	et	NNP
cord-269011-230p8rsf	176	40	al	al	NNP
cord-269011-230p8rsf	176	41	.	.	NNP
cord-269011-230p8rsf	176	42	,	,	,
cord-269011-230p8rsf	176	43	2003	2003	CD
cord-269011-230p8rsf	176	44	)	)	-RRB-
cord-269011-230p8rsf	176	45	.	.	.
cord-269011-230p8rsf	177	1	However	however	RB
cord-269011-230p8rsf	177	2	,	,	,
cord-269011-230p8rsf	177	3	the	the	DT
cord-269011-230p8rsf	177	4	efficiency	efficiency	NN
cord-269011-230p8rsf	177	5	of	of	IN
cord-269011-230p8rsf	177	6	the	the	DT
cord-269011-230p8rsf	177	7	system	system	NN
cord-269011-230p8rsf	177	8	was	be	VBD
cord-269011-230p8rsf	177	9	much	much	RB
cord-269011-230p8rsf	177	10	enhanced	enhance	VBN
cord-269011-230p8rsf	177	11	when	when	WRB
cord-269011-230p8rsf	177	12	the	the	DT
cord-269011-230p8rsf	177	13	protein	protein	NN
cord-269011-230p8rsf	177	14	was	be	VBD
cord-269011-230p8rsf	177	15	present	present	JJ
cord-269011-230p8rsf	177	16	.	.	.
cord-269011-230p8rsf	178	1	Furthermore	furthermore	RB
cord-269011-230p8rsf	178	2	,	,	,
cord-269011-230p8rsf	178	3	using	use	VBG
cord-269011-230p8rsf	178	4	an	an	DT
cord-269011-230p8rsf	178	5	in	in	FW
cord-269011-230p8rsf	178	6	vitro	vitro	FW
cord-269011-230p8rsf	178	7	system	system	NN
cord-269011-230p8rsf	178	8	,	,	,
cord-269011-230p8rsf	178	9	it	-PRON-	PRP
cord-269011-230p8rsf	178	10	was	be	VBD
cord-269011-230p8rsf	178	11	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	178	12	that	that	IN
cord-269011-230p8rsf	178	13	antibodies	antibody	NNS
cord-269011-230p8rsf	178	14	to	to	IN
cord-269011-230p8rsf	178	15	the	the	DT
cord-269011-230p8rsf	178	16	N	N	NNP
cord-269011-230p8rsf	178	17	protein	protein	NN
cord-269011-230p8rsf	178	18	,	,	,
cord-269011-230p8rsf	178	19	but	but	CC
cord-269011-230p8rsf	178	20	not	not	RB
cord-269011-230p8rsf	178	21	those	those	DT
cord-269011-230p8rsf	178	22	against	against	IN
cord-269011-230p8rsf	178	23	the	the	DT
cord-269011-230p8rsf	178	24	S	S	NNP
cord-269011-230p8rsf	178	25	and	and	CC
cord-269011-230p8rsf	178	26	M	M	NNP
cord-269011-230p8rsf	178	27	proteins	protein	NNS
cord-269011-230p8rsf	178	28	,	,	,
cord-269011-230p8rsf	178	29	inhibited	inhibit	VBN
cord-269011-230p8rsf	178	30	viral	viral	JJ
cord-269011-230p8rsf	178	31	RNA	RNA	NNP
cord-269011-230p8rsf	178	32	synthesis	synthesis	NN
cord-269011-230p8rsf	178	33	by	by	IN
cord-269011-230p8rsf	178	34	90	90	CD
cord-269011-230p8rsf	178	35	%	%	NN
cord-269011-230p8rsf	179	1	(	(	-LRB-
cord-269011-230p8rsf	179	2	Compton	Compton	NNP
cord-269011-230p8rsf	179	3	et	et	NNP
cord-269011-230p8rsf	179	4	al	al	NNP
cord-269011-230p8rsf	179	5	.	.	NNP
cord-269011-230p8rsf	179	6	,	,	,
cord-269011-230p8rsf	179	7	1987	1987	CD
cord-269011-230p8rsf	179	8	)	)	-RRB-
cord-269011-230p8rsf	179	9	.	.	.
cord-269011-230p8rsf	180	1	Interactions	interaction	NNS
cord-269011-230p8rsf	180	2	that	that	WDT
cord-269011-230p8rsf	180	3	have	have	VBP
cord-269011-230p8rsf	180	4	been	be	VBN
cord-269011-230p8rsf	180	5	observed	observe	VBN
cord-269011-230p8rsf	180	6	between	between	IN
cord-269011-230p8rsf	180	7	the	the	DT
cord-269011-230p8rsf	180	8	N	N	NNP
cord-269011-230p8rsf	180	9	protein	protein	NN
cord-269011-230p8rsf	180	10	and	and	CC
cord-269011-230p8rsf	180	11	leader	leader	NN
cord-269011-230p8rsf	180	12	/	/	SYM
cord-269011-230p8rsf	180	13	TRS	TRS	NNP
cord-269011-230p8rsf	180	14	sequences	sequence	NNS
cord-269011-230p8rsf	180	15	Nelson	Nelson	NNP
cord-269011-230p8rsf	180	16	et	et	NNP
cord-269011-230p8rsf	180	17	al	al	NNP
cord-269011-230p8rsf	180	18	.	.	NNP
cord-269011-230p8rsf	180	19	,	,	,
cord-269011-230p8rsf	180	20	2000	2000	CD
cord-269011-230p8rsf	180	21	;	;	:
cord-269011-230p8rsf	180	22	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	180	23	et	et	NNP
cord-269011-230p8rsf	180	24	al	al	NNP
cord-269011-230p8rsf	180	25	.	.	NNP
cord-269011-230p8rsf	180	26	,	,	,
cord-269011-230p8rsf	180	27	1988	1988	CD
cord-269011-230p8rsf	180	28	)	)	-RRB-
cord-269011-230p8rsf	180	29	and	and	CC
cord-269011-230p8rsf	180	30	between	between	IN
cord-269011-230p8rsf	180	31	N	n	CD
cord-269011-230p8rsf	180	32	protein	protein	NN
cord-269011-230p8rsf	180	33	and	and	CC
cord-269011-230p8rsf	180	34	the	the	DT
cord-269011-230p8rsf	180	35	3	3	CD
cord-269011-230p8rsf	180	36	0	0	CD
cord-269011-230p8rsf	180	37	UTR	UTR	NNP
cord-269011-230p8rsf	180	38	(	(	-LRB-
cord-269011-230p8rsf	180	39	Zhou	Zhou	NNP
cord-269011-230p8rsf	180	40	et	et	NNP
cord-269011-230p8rsf	180	41	al	al	NNP
cord-269011-230p8rsf	180	42	.	.	NNP
cord-269011-230p8rsf	180	43	,	,	,
cord-269011-230p8rsf	180	44	1996	1996	CD
cord-269011-230p8rsf	180	45	)	)	-RRB-
cord-269011-230p8rsf	180	46	suggest	suggest	VBP
cord-269011-230p8rsf	180	47	a	a	DT
cord-269011-230p8rsf	180	48	role	role	NN
cord-269011-230p8rsf	180	49	for	for	IN
cord-269011-230p8rsf	180	50	the	the	DT
cord-269011-230p8rsf	180	51	N	n	CD
cord-269011-230p8rsf	180	52	protein	protein	NN
cord-269011-230p8rsf	180	53	in	in	IN
cord-269011-230p8rsf	180	54	the	the	DT
cord-269011-230p8rsf	180	55	discontinuous	discontinuous	JJ
cord-269011-230p8rsf	180	56	transcription	transcription	NN
cord-269011-230p8rsf	180	57	process	process	NN
cord-269011-230p8rsf	180	58	.	.	.
cord-269011-230p8rsf	181	1	Furthermore	furthermore	RB
cord-269011-230p8rsf	181	2	,	,	,
cord-269011-230p8rsf	181	3	the	the	DT
cord-269011-230p8rsf	181	4	N	N	NNP
cord-269011-230p8rsf	181	5	protein	protein	NN
cord-269011-230p8rsf	181	6	was	be	VBD
cord-269011-230p8rsf	181	7	also	also	RB
cord-269011-230p8rsf	181	8	shown	show	VBN
cord-269011-230p8rsf	181	9	to	to	TO
cord-269011-230p8rsf	181	10	interact	interact	VB
cord-269011-230p8rsf	181	11	with	with	IN
cord-269011-230p8rsf	181	12	cellular	cellular	JJ
cord-269011-230p8rsf	181	13	proteins	protein	NNS
cord-269011-230p8rsf	181	14	that	that	WDT
cord-269011-230p8rsf	181	15	play	play	VBP
cord-269011-230p8rsf	181	16	a	a	DT
cord-269011-230p8rsf	181	17	role	role	NN
cord-269011-230p8rsf	181	18	in	in	IN
cord-269011-230p8rsf	181	19	coronavirus	coronavirus	NN
cord-269011-230p8rsf	181	20	RNA	RNA	NNP
cord-269011-230p8rsf	181	21	replication	replication	NN
cord-269011-230p8rsf	181	22	and	and	CC
cord-269011-230p8rsf	181	23	transcription	transcription	NN
cord-269011-230p8rsf	181	24	(	(	-LRB-
cord-269011-230p8rsf	181	25	Choi	Choi	NNP
cord-269011-230p8rsf	181	26	et	et	FW
cord-269011-230p8rsf	181	27	al	al	NNP
cord-269011-230p8rsf	181	28	.	.	NNP
cord-269011-230p8rsf	181	29	,	,	,
cord-269011-230p8rsf	181	30	2002	2002	CD
cord-269011-230p8rsf	181	31	;	;	:
cord-269011-230p8rsf	181	32	Shi	Shi	NNP
cord-269011-230p8rsf	181	33	et	et	FW
cord-269011-230p8rsf	181	34	al	al	NNP
cord-269011-230p8rsf	181	35	.	.	NNP
cord-269011-230p8rsf	181	36	,	,	,
cord-269011-230p8rsf	181	37	2000	2000	CD
cord-269011-230p8rsf	181	38	)	)	-RRB-
cord-269011-230p8rsf	181	39	.	.	.
cord-269011-230p8rsf	182	1	In	in	IN
cord-269011-230p8rsf	182	2	addition	addition	NN
cord-269011-230p8rsf	182	3	,	,	,
cord-269011-230p8rsf	182	4	the	the	DT
cord-269011-230p8rsf	182	5	N	N	NNP
cord-269011-230p8rsf	182	6	protein	protein	NN
cord-269011-230p8rsf	182	7	was	be	VBD
cord-269011-230p8rsf	182	8	reported	report	VBN
cord-269011-230p8rsf	182	9	to	to	TO
cord-269011-230p8rsf	182	10	function	function	VB
cord-269011-230p8rsf	182	11	as	as	IN
cord-269011-230p8rsf	182	12	a	a	DT
cord-269011-230p8rsf	182	13	translational	translational	JJ
cord-269011-230p8rsf	182	14	enhancer	enhancer	NN
cord-269011-230p8rsf	182	15	of	of	IN
cord-269011-230p8rsf	182	16	MHV	MHV	NNP
cord-269011-230p8rsf	182	17	sgRNAs	sgrna	NNS
cord-269011-230p8rsf	183	1	(	(	-LRB-
cord-269011-230p8rsf	183	2	Tahara	Tahara	NNP
cord-269011-230p8rsf	183	3	et	et	FW
cord-269011-230p8rsf	183	4	al	al	NNP
cord-269011-230p8rsf	183	5	.	.	NNP
cord-269011-230p8rsf	183	6	,	,	,
cord-269011-230p8rsf	183	7	1998	1998	CD
cord-269011-230p8rsf	183	8	)	)	-RRB-
cord-269011-230p8rsf	183	9	.	.	.
cord-269011-230p8rsf	184	1	The	the	DT
cord-269011-230p8rsf	184	2	M	M	NNP
cord-269011-230p8rsf	184	3	protein	protein	NN
cord-269011-230p8rsf	184	4	(	(	-LRB-
cord-269011-230p8rsf	184	5	previously	previously	RB
cord-269011-230p8rsf	184	6	known	know	VBN
cord-269011-230p8rsf	184	7	as	as	IN
cord-269011-230p8rsf	184	8	E1	e1	NN
cord-269011-230p8rsf	184	9	protein	protein	NN
cord-269011-230p8rsf	184	10	)	)	-RRB-
cord-269011-230p8rsf	184	11	is	be	VBZ
cord-269011-230p8rsf	184	12	the	the	DT
cord-269011-230p8rsf	184	13	most	most	RBS
cord-269011-230p8rsf	184	14	abundant	abundant	JJ
cord-269011-230p8rsf	184	15	envelope	envelope	NN
cord-269011-230p8rsf	184	16	protein	protein	NN
cord-269011-230p8rsf	184	17	.	.	.
cord-269011-230p8rsf	185	1	It	-PRON-	PRP
cord-269011-230p8rsf	185	2	is	be	VBZ
cord-269011-230p8rsf	185	3	the	the	DT
cord-269011-230p8rsf	185	4	"	"	``
cord-269011-230p8rsf	185	5	building	building	NN
cord-269011-230p8rsf	185	6	block	block	NN
cord-269011-230p8rsf	185	7	"	"	''
cord-269011-230p8rsf	185	8	of	of	IN
cord-269011-230p8rsf	185	9	the	the	DT
cord-269011-230p8rsf	185	10	coronavirion	coronavirion	NN
cord-269011-230p8rsf	185	11	and	and	CC
cord-269011-230p8rsf	185	12	has	have	VBZ
cord-269011-230p8rsf	185	13	been	be	VBN
cord-269011-230p8rsf	185	14	shown	show	VBN
cord-269011-230p8rsf	185	15	to	to	TO
cord-269011-230p8rsf	185	16	interact	interact	VB
cord-269011-230p8rsf	185	17	with	with	IN
cord-269011-230p8rsf	185	18	virtually	virtually	RB
cord-269011-230p8rsf	185	19	every	every	DT
cord-269011-230p8rsf	185	20	other	other	JJ
cord-269011-230p8rsf	185	21	virion	virion	NN
cord-269011-230p8rsf	185	22	component	component	NN
cord-269011-230p8rsf	185	23	,	,	,
cord-269011-230p8rsf	185	24	as	as	IN
cord-269011-230p8rsf	185	25	detailed	detail	VBN
cord-269011-230p8rsf	185	26	in	in	IN
cord-269011-230p8rsf	185	27	Section	Section	NNP
cord-269011-230p8rsf	185	28	IV	IV	NNP
cord-269011-230p8rsf	185	29	.	.	.
cord-269011-230p8rsf	186	1	The	the	DT
cord-269011-230p8rsf	186	2	M	M	NNP
cord-269011-230p8rsf	186	3	protein	protein	NN
cord-269011-230p8rsf	186	4	is	be	VBZ
cord-269011-230p8rsf	186	5	221	221	CD
cord-269011-230p8rsf	186	6	-	-	SYM
cord-269011-230p8rsf	186	7	230	230	CD
cord-269011-230p8rsf	186	8	residues	residue	NNS
cord-269011-230p8rsf	186	9	in	in	IN
cord-269011-230p8rsf	186	10	length	length	NN
cord-269011-230p8rsf	186	11	,	,	,
cord-269011-230p8rsf	186	12	except	except	IN
cord-269011-230p8rsf	186	13	for	for	IN
cord-269011-230p8rsf	186	14	the	the	DT
cord-269011-230p8rsf	186	15	group	group	NN
cord-269011-230p8rsf	186	16	1	1	CD
cord-269011-230p8rsf	186	17	M	M	NNP
cord-269011-230p8rsf	186	18	proteins	protein	NNS
cord-269011-230p8rsf	186	19	,	,	,
cord-269011-230p8rsf	186	20	of	of	IN
cord-269011-230p8rsf	186	21	which	which	WDT
cord-269011-230p8rsf	186	22	the	the	DT
cord-269011-230p8rsf	186	23	amino	amino	NN
cord-269011-230p8rsf	186	24	terminus	terminus	NN
cord-269011-230p8rsf	186	25	is	be	VBZ
cord-269011-230p8rsf	186	26	about	about	RB
cord-269011-230p8rsf	186	27	30	30	CD
cord-269011-230p8rsf	186	28	residues	residue	NNS
cord-269011-230p8rsf	186	29	longer	long	RBR
cord-269011-230p8rsf	186	30	.	.	.
cord-269011-230p8rsf	187	1	Despite	despite	IN
cord-269011-230p8rsf	187	2	large	large	JJ
cord-269011-230p8rsf	187	3	differences	difference	NNS
cord-269011-230p8rsf	187	4	in	in	IN
cord-269011-230p8rsf	187	5	primary	primary	JJ
cord-269011-230p8rsf	187	6	sequences	sequence	NNS
cord-269011-230p8rsf	187	7	between	between	IN
cord-269011-230p8rsf	187	8	M	M	NNP
cord-269011-230p8rsf	187	9	proteins	protein	NNS
cord-269011-230p8rsf	187	10	from	from	IN
cord-269011-230p8rsf	187	11	different	different	JJ
cord-269011-230p8rsf	187	12	antigenic	antigenic	JJ
cord-269011-230p8rsf	187	13	groups	group	NNS
cord-269011-230p8rsf	187	14	,	,	,
cord-269011-230p8rsf	187	15	their	-PRON-	PRP$
cord-269011-230p8rsf	187	16	hydropathicity	hydropathicity	NN
cord-269011-230p8rsf	187	17	profiles	profile	NNS
cord-269011-230p8rsf	187	18	are	be	VBP
cord-269011-230p8rsf	187	19	remarkably	remarkably	RB
cord-269011-230p8rsf	187	20	similar	similar	JJ
cord-269011-230p8rsf	187	21	.	.	.
cord-269011-230p8rsf	188	1	The	the	DT
cord-269011-230p8rsf	188	2	M	M	NNP
cord-269011-230p8rsf	188	3	protein	protein	NN
cord-269011-230p8rsf	188	4	is	be	VBZ
cord-269011-230p8rsf	188	5	highly	highly	RB
cord-269011-230p8rsf	188	6	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	188	7	.	.	.
cord-269011-230p8rsf	189	1	It	-PRON-	PRP
cord-269011-230p8rsf	189	2	has	have	VBZ
cord-269011-230p8rsf	189	3	three	three	CD
cord-269011-230p8rsf	189	4	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	189	5	domains	domain	NNS
cord-269011-230p8rsf	189	6	alternating	alternate	VBG
cord-269011-230p8rsf	189	7	with	with	IN
cord-269011-230p8rsf	189	8	short	short	JJ
cord-269011-230p8rsf	189	9	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	189	10	regions	region	NNS
cord-269011-230p8rsf	189	11	in	in	IN
cord-269011-230p8rsf	189	12	the	the	DT
cord-269011-230p8rsf	189	13	amino	amino	NN
cord-269011-230p8rsf	189	14	-	-	HYPH
cord-269011-230p8rsf	189	15	terminal	terminal	NN
cord-269011-230p8rsf	189	16	half	half	NN
cord-269011-230p8rsf	189	17	of	of	IN
cord-269011-230p8rsf	189	18	the	the	DT
cord-269011-230p8rsf	189	19	protein	protein	NN
cord-269011-230p8rsf	189	20	,	,	,
cord-269011-230p8rsf	189	21	with	with	IN
cord-269011-230p8rsf	189	22	the	the	DT
cord-269011-230p8rsf	189	23	exception	exception	NN
cord-269011-230p8rsf	189	24	of	of	IN
cord-269011-230p8rsf	189	25	the	the	DT
cord-269011-230p8rsf	189	26	aforementioned	aforementioned	JJ
cord-269011-230p8rsf	189	27	group	group	NN
cord-269011-230p8rsf	189	28	1	1	CD
cord-269011-230p8rsf	189	29	M	M	NNP
cord-269011-230p8rsf	189	30	proteins	protein	NNS
cord-269011-230p8rsf	189	31	,	,	,
cord-269011-230p8rsf	189	32	which	which	WDT
cord-269011-230p8rsf	189	33	have	have	VBP
cord-269011-230p8rsf	189	34	at	at	IN
cord-269011-230p8rsf	189	35	their	-PRON-	PRP$
cord-269011-230p8rsf	189	36	amino	amino	NN
cord-269011-230p8rsf	189	37	terminus	terminus	NN
cord-269011-230p8rsf	189	38	a	a	DT
cord-269011-230p8rsf	189	39	fourth	fourth	JJ
cord-269011-230p8rsf	189	40	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	189	41	domain	domain	NN
cord-269011-230p8rsf	189	42	that	that	WDT
cord-269011-230p8rsf	189	43	functions	function	VBZ
cord-269011-230p8rsf	189	44	as	as	IN
cord-269011-230p8rsf	189	45	a	a	DT
cord-269011-230p8rsf	189	46	cleavable	cleavable	JJ
cord-269011-230p8rsf	189	47	signal	signal	NN
cord-269011-230p8rsf	189	48	peptide	peptide	NN
cord-269011-230p8rsf	189	49	.	.	.
cord-269011-230p8rsf	190	1	The	the	DT
cord-269011-230p8rsf	190	2	carboxy	carboxy	JJ
cord-269011-230p8rsf	190	3	-	-	HYPH
cord-269011-230p8rsf	190	4	terminal	terminal	NN
cord-269011-230p8rsf	190	5	half	half	NN
cord-269011-230p8rsf	190	6	of	of	IN
cord-269011-230p8rsf	190	7	the	the	DT
cord-269011-230p8rsf	190	8	protein	protein	NN
cord-269011-230p8rsf	190	9	is	be	VBZ
cord-269011-230p8rsf	190	10	amphipathic	amphipathic	JJ
cord-269011-230p8rsf	190	11	,	,	,
cord-269011-230p8rsf	190	12	with	with	IN
cord-269011-230p8rsf	190	13	a	a	DT
cord-269011-230p8rsf	190	14	short	short	JJ
cord-269011-230p8rsf	190	15	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	190	16	domain	domain	NN
cord-269011-230p8rsf	190	17	at	at	IN
cord-269011-230p8rsf	190	18	the	the	DT
cord-269011-230p8rsf	190	19	carboxy	carboxy	JJ
cord-269011-230p8rsf	190	20	-	-	HYPH
cord-269011-230p8rsf	190	21	terminal	terminal	NN
cord-269011-230p8rsf	190	22	end	end	NN
cord-269011-230p8rsf	191	1	(	(	-LRB-
cord-269011-230p8rsf	191	2	Fig	Fig	NNP
cord-269011-230p8rsf	191	3	.	.	NNP
cord-269011-230p8rsf	191	4	4	4	CD
cord-269011-230p8rsf	191	5	)	)	-RRB-
cord-269011-230p8rsf	191	6	.	.	.
cord-269011-230p8rsf	192	1	In	in	IN
cord-269011-230p8rsf	192	2	the	the	DT
cord-269011-230p8rsf	192	3	center	center	NN
cord-269011-230p8rsf	192	4	of	of	IN
cord-269011-230p8rsf	192	5	the	the	DT
cord-269011-230p8rsf	192	6	protein	protein	NN
cord-269011-230p8rsf	192	7	,	,	,
cord-269011-230p8rsf	192	8	directly	directly	RB
cord-269011-230p8rsf	192	9	adjacent	adjacent	JJ
cord-269011-230p8rsf	192	10	to	to	IN
cord-269011-230p8rsf	192	11	the	the	DT
cord-269011-230p8rsf	192	12	third	third	JJ
cord-269011-230p8rsf	192	13	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	192	14	domain	domain	NN
cord-269011-230p8rsf	192	15	,	,	,
cord-269011-230p8rsf	192	16	is	be	VBZ
cord-269011-230p8rsf	192	17	a	a	DT
cord-269011-230p8rsf	192	18	stretch	stretch	NN
cord-269011-230p8rsf	192	19	of	of	IN
cord-269011-230p8rsf	192	20	eight	eight	CD
cord-269011-230p8rsf	192	21	amino	amino	NN
cord-269011-230p8rsf	192	22	acids	acid	NNS
cord-269011-230p8rsf	192	23	that	that	WDT
cord-269011-230p8rsf	192	24	is	be	VBZ
cord-269011-230p8rsf	192	25	well	well	RB
cord-269011-230p8rsf	192	26	conserved	conserved	JJ
cord-269011-230p8rsf	192	27	(	(	-LRB-
cord-269011-230p8rsf	192	28	SWWSFNPE	SWWSFNPE	NNP
cord-269011-230p8rsf	192	29	)	)	-RRB-
cord-269011-230p8rsf	192	30	.	.	.
cord-269011-230p8rsf	193	1	The	the	DT
cord-269011-230p8rsf	193	2	conservation	conservation	NN
cord-269011-230p8rsf	193	3	of	of	IN
cord-269011-230p8rsf	193	4	the	the	DT
cord-269011-230p8rsf	193	5	overall	overall	JJ
cord-269011-230p8rsf	193	6	chemical	chemical	NN
cord-269011-230p8rsf	193	7	features	feature	NNS
cord-269011-230p8rsf	193	8	suggests	suggest	VBZ
cord-269011-230p8rsf	193	9	that	that	IN
cord-269011-230p8rsf	193	10	there	there	EX
cord-269011-230p8rsf	193	11	are	be	VBP
cord-269011-230p8rsf	193	12	rigid	rigid	JJ
cord-269011-230p8rsf	193	13	structural	structural	JJ
cord-269011-230p8rsf	193	14	constraints	constraint	NNS
cord-269011-230p8rsf	193	15	on	on	IN
cord-269011-230p8rsf	193	16	the	the	DT
cord-269011-230p8rsf	193	17	M	M	NNP
cord-269011-230p8rsf	193	18	protein	protein	NN
cord-269011-230p8rsf	193	19	as	as	IN
cord-269011-230p8rsf	193	20	a	a	DT
cord-269011-230p8rsf	193	21	result	result	NN
cord-269011-230p8rsf	193	22	of	of	IN
cord-269011-230p8rsf	193	23	functional	functional	JJ
cord-269011-230p8rsf	193	24	requirements	requirement	NNS
cord-269011-230p8rsf	193	25	(	(	-LRB-
cord-269011-230p8rsf	193	26	for	for	IN
cord-269011-230p8rsf	193	27	a	a	DT
cord-269011-230p8rsf	193	28	review	review	NN
cord-269011-230p8rsf	193	29	on	on	IN
cord-269011-230p8rsf	193	30	the	the	DT
cord-269011-230p8rsf	193	31	M	M	NNP
cord-269011-230p8rsf	193	32	protein	protein	NN
cord-269011-230p8rsf	193	33	,	,	,
cord-269011-230p8rsf	193	34	see	see	VB
cord-269011-230p8rsf	193	35	Rottier	Rottier	NNP
cord-269011-230p8rsf	193	36	,	,	,
cord-269011-230p8rsf	193	37	1995	1995	CD
cord-269011-230p8rsf	193	38	)	)	-RRB-
cord-269011-230p8rsf	193	39	.	.	.
cord-269011-230p8rsf	194	1	Biochemical	biochemical	JJ
cord-269011-230p8rsf	194	2	and	and	CC
cord-269011-230p8rsf	194	3	theoretical	theoretical	JJ
cord-269011-230p8rsf	194	4	studies	study	NNS
cord-269011-230p8rsf	194	5	led	lead	VBD
cord-269011-230p8rsf	194	6	to	to	IN
cord-269011-230p8rsf	194	7	a	a	DT
cord-269011-230p8rsf	194	8	topological	topological	JJ
cord-269011-230p8rsf	194	9	model	model	NN
cord-269011-230p8rsf	194	10	for	for	IN
cord-269011-230p8rsf	194	11	the	the	DT
cord-269011-230p8rsf	194	12	MHV	MHV	NNP
cord-269011-230p8rsf	194	13	M	M	NNP
cord-269011-230p8rsf	194	14	protein	protein	NN
cord-269011-230p8rsf	194	15	Rottier	Rottier	NNP
cord-269011-230p8rsf	194	16	et	et	NNP
cord-269011-230p8rsf	194	17	al	al	NNP
cord-269011-230p8rsf	194	18	.	.	.
cord-269011-230p8rsf	195	1	,	,	,
cord-269011-230p8rsf	195	2	1984	1984	CD
cord-269011-230p8rsf	195	3	Rottier	Rottier	NNP
cord-269011-230p8rsf	195	4	et	et	NNP
cord-269011-230p8rsf	195	5	al	al	NNP
cord-269011-230p8rsf	195	6	.	.	NNP
cord-269011-230p8rsf	195	7	,	,	,
cord-269011-230p8rsf	195	8	,	,	,
cord-269011-230p8rsf	195	9	1986	1986	CD
cord-269011-230p8rsf	195	10	,	,	,
cord-269011-230p8rsf	195	11	in	in	IN
cord-269011-230p8rsf	195	12	which	which	WDT
cord-269011-230p8rsf	195	13	the	the	DT
cord-269011-230p8rsf	195	14	polypeptide	polypeptide	NN
cord-269011-230p8rsf	195	15	spans	span	VBZ
cord-269011-230p8rsf	195	16	the	the	DT
cord-269011-230p8rsf	195	17	lipid	lipid	NN
cord-269011-230p8rsf	195	18	bilayer	bilayer	NN
cord-269011-230p8rsf	195	19	three	three	CD
cord-269011-230p8rsf	195	20	times	time	NNS
cord-269011-230p8rsf	195	21	,	,	,
cord-269011-230p8rsf	195	22	leaving	leave	VBG
cord-269011-230p8rsf	195	23	a	a	DT
cord-269011-230p8rsf	195	24	small	small	JJ
cord-269011-230p8rsf	195	25	amino	amino	NN
cord-269011-230p8rsf	195	26	-	-	HYPH
cord-269011-230p8rsf	195	27	terminal	terminal	NN
cord-269011-230p8rsf	195	28	domain	domain	NN
cord-269011-230p8rsf	195	29	(	(	-LRB-
cord-269011-230p8rsf	195	30	15	15	CD
cord-269011-230p8rsf	195	31	-	-	SYM
cord-269011-230p8rsf	195	32	35	35	CD
cord-269011-230p8rsf	195	33	residues	residue	NNS
cord-269011-230p8rsf	195	34	)	)	-RRB-
cord-269011-230p8rsf	195	35	in	in	IN
cord-269011-230p8rsf	195	36	the	the	DT
cord-269011-230p8rsf	195	37	lumen	lumen	NN
cord-269011-230p8rsf	195	38	of	of	IN
cord-269011-230p8rsf	195	39	intracellular	intracellular	JJ
cord-269011-230p8rsf	195	40	organelles	organelle	NNS
cord-269011-230p8rsf	195	41	(	(	-LRB-
cord-269011-230p8rsf	195	42	or	or	CC
cord-269011-230p8rsf	195	43	outside	outside	IN
cord-269011-230p8rsf	195	44	the	the	DT
cord-269011-230p8rsf	195	45	virus	virus	NN
cord-269011-230p8rsf	195	46	)	)	-RRB-
cord-269011-230p8rsf	195	47	,	,	,
cord-269011-230p8rsf	195	48	whereas	whereas	IN
cord-269011-230p8rsf	195	49	the	the	DT
cord-269011-230p8rsf	195	50	carboxyterminal	carboxyterminal	JJ
cord-269011-230p8rsf	195	51	half	half	NN
cord-269011-230p8rsf	195	52	of	of	IN
cord-269011-230p8rsf	195	53	the	the	DT
cord-269011-230p8rsf	195	54	protein	protein	NN
cord-269011-230p8rsf	195	55	is	be	VBZ
cord-269011-230p8rsf	195	56	located	locate	VBN
cord-269011-230p8rsf	195	57	on	on	IN
cord-269011-230p8rsf	195	58	the	the	DT
cord-269011-230p8rsf	195	59	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	195	60	side	side	NN
cord-269011-230p8rsf	195	61	of	of	IN
cord-269011-230p8rsf	195	62	the	the	DT
cord-269011-230p8rsf	195	63	membrane	membrane	NN
cord-269011-230p8rsf	195	64	(	(	-LRB-
cord-269011-230p8rsf	195	65	or	or	CC
cord-269011-230p8rsf	195	66	inside	inside	IN
cord-269011-230p8rsf	195	67	the	the	DT
cord-269011-230p8rsf	195	68	virion	virion	NN
cord-269011-230p8rsf	195	69	)	)	-RRB-
cord-269011-230p8rsf	195	70	.	.	.
cord-269011-230p8rsf	196	1	The	the	DT
cord-269011-230p8rsf	196	2	lumenal	lumenal	JJ
cord-269011-230p8rsf	196	3	domain	domain	NN
cord-269011-230p8rsf	196	4	and	and	CC
cord-269011-230p8rsf	196	5	the	the	DT
cord-269011-230p8rsf	196	6	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	196	7	carboxy	carboxy	JJ
cord-269011-230p8rsf	196	8	terminus	terminus	NN
cord-269011-230p8rsf	196	9	are	be	VBP
cord-269011-230p8rsf	196	10	susceptible	susceptible	JJ
cord-269011-230p8rsf	196	11	to	to	IN
cord-269011-230p8rsf	196	12	protease	protease	JJ
cord-269011-230p8rsf	196	13	digestion	digestion	NN
cord-269011-230p8rsf	196	14	and	and	CC
cord-269011-230p8rsf	196	15	are	be	VBP
cord-269011-230p8rsf	196	16	thus	thus	RB
cord-269011-230p8rsf	196	17	exposed	expose	VBN
cord-269011-230p8rsf	196	18	.	.	.
cord-269011-230p8rsf	197	1	The	the	DT
cord-269011-230p8rsf	197	2	bulk	bulk	NN
cord-269011-230p8rsf	197	3	of	of	IN
cord-269011-230p8rsf	197	4	the	the	DT
cord-269011-230p8rsf	197	5	carboxy	carboxy	JJ
cord-269011-230p8rsf	197	6	-	-	HYPH
cord-269011-230p8rsf	197	7	terminal	terminal	NN
cord-269011-230p8rsf	197	8	half	half	NN
cord-269011-230p8rsf	197	9	of	of	IN
cord-269011-230p8rsf	197	10	the	the	DT
cord-269011-230p8rsf	197	11	M	M	NNP
cord-269011-230p8rsf	197	12	protein	protein	NN
cord-269011-230p8rsf	197	13	is	be	VBZ
cord-269011-230p8rsf	197	14	protease	protease	NN
cord-269011-230p8rsf	197	15	resistant	resistant	JJ
cord-269011-230p8rsf	197	16	,	,	,
cord-269011-230p8rsf	197	17	indicating	indicate	VBG
cord-269011-230p8rsf	197	18	that	that	IN
cord-269011-230p8rsf	197	19	the	the	DT
cord-269011-230p8rsf	197	20	amphipathic	amphipathic	JJ
cord-269011-230p8rsf	197	21	part	part	NN
cord-269011-230p8rsf	197	22	of	of	IN
cord-269011-230p8rsf	197	23	the	the	DT
cord-269011-230p8rsf	197	24	protein	protein	NN
cord-269011-230p8rsf	197	25	is	be	VBZ
cord-269011-230p8rsf	197	26	either	either	CC
cord-269011-230p8rsf	197	27	folded	fold	VBN
cord-269011-230p8rsf	197	28	tightly	tightly	RB
cord-269011-230p8rsf	197	29	or	or	CC
cord-269011-230p8rsf	197	30	embedded	embed	VBN
cord-269011-230p8rsf	197	31	in	in	IN
cord-269011-230p8rsf	197	32	the	the	DT
cord-269011-230p8rsf	197	33	polar	polar	JJ
cord-269011-230p8rsf	197	34	surface	surface	NN
cord-269011-230p8rsf	197	35	of	of	IN
cord-269011-230p8rsf	197	36	the	the	DT
cord-269011-230p8rsf	197	37	membrane	membrane	NN
cord-269011-230p8rsf	197	38	.	.	.
cord-269011-230p8rsf	198	1	Indeed	indeed	RB
cord-269011-230p8rsf	198	2	,	,	,
cord-269011-230p8rsf	198	3	a	a	DT
cord-269011-230p8rsf	198	4	mutant	mutant	JJ
cord-269011-230p8rsf	198	5	lacking	lack	VBG
cord-269011-230p8rsf	198	6	all	all	DT
cord-269011-230p8rsf	198	7	three	three	CD
cord-269011-230p8rsf	198	8	transmembrane	transmembrane	NN
cord-269011-230p8rsf	198	9	domains	domain	NNS
cord-269011-230p8rsf	198	10	was	be	VBD
cord-269011-230p8rsf	198	11	found	find	VBN
cord-269011-230p8rsf	198	12	to	to	TO
cord-269011-230p8rsf	198	13	be	be	VB
cord-269011-230p8rsf	198	14	associated	associate	VBN
cord-269011-230p8rsf	198	15	with	with	IN
cord-269011-230p8rsf	198	16	membranes	membrane	NNS
cord-269011-230p8rsf	198	17	(	(	-LRB-
cord-269011-230p8rsf	198	18	Mayer	Mayer	NNP
cord-269011-230p8rsf	198	19	et	et	NNP
cord-269011-230p8rsf	198	20	al	al	NNP
cord-269011-230p8rsf	198	21	.	.	NNP
cord-269011-230p8rsf	198	22	,	,	,
cord-269011-230p8rsf	198	23	1988	1988	CD
cord-269011-230p8rsf	198	24	)	)	-RRB-
cord-269011-230p8rsf	198	25	.	.	.
cord-269011-230p8rsf	199	1	The	the	DT
cord-269011-230p8rsf	199	2	model	model	NN
cord-269011-230p8rsf	199	3	for	for	IN
cord-269011-230p8rsf	199	4	the	the	DT
cord-269011-230p8rsf	199	5	disposition	disposition	NN
cord-269011-230p8rsf	199	6	of	of	IN
cord-269011-230p8rsf	199	7	the	the	DT
cord-269011-230p8rsf	199	8	M	M	NNP
cord-269011-230p8rsf	199	9	protein	protein	NN
cord-269011-230p8rsf	199	10	in	in	IN
cord-269011-230p8rsf	199	11	the	the	DT
cord-269011-230p8rsf	199	12	membrane	membrane	NN
cord-269011-230p8rsf	199	13	was	be	VBD
cord-269011-230p8rsf	199	14	confirm	confirm	VB
cord-269011-230p8rsf	199	15	ed	ed	NN
cord-269011-230p8rsf	199	16	for	for	IN
cord-269011-230p8rsf	199	17	IBV	IBV	NNP
cord-269011-230p8rsf	200	1	(	(	-LRB-
cord-269011-230p8rsf	200	2	Cavanag	Cavanag	NNP
cord-269011-230p8rsf	200	3	h	h	NNP
cord-269011-230p8rsf	200	4	et	et	FW
cord-269011-230p8rsf	200	5	al	al	NNP
cord-269011-230p8rsf	200	6	.	.	NNP
cord-269011-230p8rsf	200	7	,	,	,
cord-269011-230p8rsf	200	8	1986	1986	CD
cord-269011-230p8rsf	200	9	)	)	-RRB-
cord-269011-230p8rsf	200	10	.	.	.
cord-269011-230p8rsf	201	1	Interest	interest	NN
cord-269011-230p8rsf	201	2	ingly	ingly	RB
cord-269011-230p8rsf	201	3	,	,	,
cord-269011-230p8rsf	201	4	the	the	DT
cord-269011-230p8rsf	201	5	FIG	FIG	NNP
cord-269011-230p8rsf	201	6	4	4	CD
cord-269011-230p8rsf	201	7	.	.	.
cord-269011-230p8rsf	202	1	Membrane	membrane	NN
cord-269011-230p8rsf	202	2	topology	topology	NN
cord-269011-230p8rsf	202	3	of	of	IN
cord-269011-230p8rsf	202	4	the	the	DT
cord-269011-230p8rsf	202	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	202	6	envelope	envelope	NN
cord-269011-230p8rsf	202	7	proteins	protein	NNS
cord-269011-230p8rsf	202	8	.	.	.
cord-269011-230p8rsf	203	1	The	the	DT
cord-269011-230p8rsf	203	2	HE	HE	NNP
cord-269011-230p8rsf	203	3	and	and	CC
cord-269011-230p8rsf	203	4	S	S	NNP
cord-269011-230p8rsf	203	5	proteins	protein	NNS
cord-269011-230p8rsf	203	6	are	be	VBP
cord-269011-230p8rsf	203	7	both	both	DT
cord-269011-230p8rsf	203	8	type	type	NN
cord-269011-230p8rsf	203	9	I	-PRON-	PRP
cord-269011-230p8rsf	203	10	membrane	membrane	NN
cord-269011-230p8rsf	203	11	proteins	protein	NNS
cord-269011-230p8rsf	203	12	,	,	,
cord-269011-230p8rsf	203	13	with	with	IN
cord-269011-230p8rsf	203	14	short	short	JJ
cord-269011-230p8rsf	203	15	carboxy	carboxy	JJ
cord-269011-230p8rsf	203	16	-	-	HYPH
cord-269011-230p8rsf	203	17	terminal	terminal	NN
cord-269011-230p8rsf	203	18	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	203	19	tails	tail	NNS
cord-269011-230p8rsf	203	20	.	.	.
cord-269011-230p8rsf	204	1	The	the	DT
cord-269011-230p8rsf	204	2	HE	HE	NNP
cord-269011-230p8rsf	204	3	protein	protein	NN
cord-269011-230p8rsf	204	4	forms	form	VBZ
cord-269011-230p8rsf	204	5	disulfide	disulfide	RB
cord-269011-230p8rsf	204	6	-	-	HYPH
cord-269011-230p8rsf	204	7	linked	link	VBN
cord-269011-230p8rsf	204	8	homodimers	homodimer	NNS
cord-269011-230p8rsf	204	9	,	,	,
cord-269011-230p8rsf	204	10	whereas	whereas	IN
cord-269011-230p8rsf	204	11	the	the	DT
cord-269011-230p8rsf	204	12	S	S	NNP
cord-269011-230p8rsf	204	13	protein	protein	NN
cord-269011-230p8rsf	204	14	forms	form	NNS
cord-269011-230p8rsf	204	15	noncovalently	noncovalently	RB
cord-269011-230p8rsf	204	16	linked	link	VBN
cord-269011-230p8rsf	204	17	homotrimers	homotrimer	NNS
cord-269011-230p8rsf	204	18	.	.	.
cord-269011-230p8rsf	205	1	The	the	DT
cord-269011-230p8rsf	205	2	S1	s1	NN
cord-269011-230p8rsf	205	3	subunits	subunit	NNS
cord-269011-230p8rsf	205	4	presumably	presumably	RB
cord-269011-230p8rsf	205	5	constitute	constitute	VBP
cord-269011-230p8rsf	205	6	the	the	DT
cord-269011-230p8rsf	205	7	globular	globular	JJ
cord-269011-230p8rsf	205	8	head	head	NN
cord-269011-230p8rsf	205	9	,	,	,
cord-269011-230p8rsf	205	10	whereas	whereas	IN
cord-269011-230p8rsf	205	11	the	the	DT
cord-269011-230p8rsf	205	12	S2	s2	NN
cord-269011-230p8rsf	205	13	subunits	subunit	NNS
cord-269011-230p8rsf	205	14	form	form	VBP
cord-269011-230p8rsf	205	15	the	the	DT
cord-269011-230p8rsf	205	16	stalk	stalk	NN
cord-269011-230p8rsf	205	17	-	-	HYPH
cord-269011-230p8rsf	205	18	like	like	JJ
cord-269011-230p8rsf	205	19	region	region	NN
cord-269011-230p8rsf	205	20	of	of	IN
cord-269011-230p8rsf	205	21	the	the	DT
cord-269011-230p8rsf	205	22	spike	spike	NN
cord-269011-230p8rsf	205	23	.	.	.
cord-269011-230p8rsf	206	1	The	the	DT
cord-269011-230p8rsf	206	2	M	M	NNP
cord-269011-230p8rsf	206	3	protein	protein	NN
cord-269011-230p8rsf	206	4	spans	span	VBZ
cord-269011-230p8rsf	206	5	the	the	DT
cord-269011-230p8rsf	206	6	lipid	lipid	NN
cord-269011-230p8rsf	206	7	bilayer	bilayer	NN
cord-269011-230p8rsf	206	8	three	three	CD
cord-269011-230p8rsf	206	9	times	time	NNS
cord-269011-230p8rsf	206	10	,	,	,
cord-269011-230p8rsf	206	11	leaving	leave	VBG
cord-269011-230p8rsf	206	12	a	a	DT
cord-269011-230p8rsf	206	13	small	small	JJ
cord-269011-230p8rsf	206	14	amino	amino	NN
cord-269011-230p8rsf	206	15	-	-	HYPH
cord-269011-230p8rsf	206	16	terminal	terminal	NN
cord-269011-230p8rsf	206	17	domain	domain	NN
cord-269011-230p8rsf	206	18	in	in	IN
cord-269011-230p8rsf	206	19	the	the	DT
cord-269011-230p8rsf	206	20	lumen	lumen	NN
cord-269011-230p8rsf	206	21	of	of	IN
cord-269011-230p8rsf	206	22	intracellular	intracellular	JJ
cord-269011-230p8rsf	206	23	organelles	organelle	NNS
cord-269011-230p8rsf	206	24	(	(	-LRB-
cord-269011-230p8rsf	206	25	or	or	CC
cord-269011-230p8rsf	206	26	on	on	IN
cord-269011-230p8rsf	206	27	the	the	DT
cord-269011-230p8rsf	206	28	outside	outside	NN
cord-269011-230p8rsf	206	29	of	of	IN
cord-269011-230p8rsf	206	30	the	the	DT
cord-269011-230p8rsf	206	31	virion	virion	NN
cord-269011-230p8rsf	206	32	)	)	-RRB-
cord-269011-230p8rsf	206	33	,	,	,
cord-269011-230p8rsf	206	34	whereas	whereas	IN
cord-269011-230p8rsf	206	35	the	the	DT
cord-269011-230p8rsf	206	36	carboxy	carboxy	JJ
cord-269011-230p8rsf	206	37	-	-	HYPH
cord-269011-230p8rsf	206	38	terminal	terminal	NN
cord-269011-230p8rsf	206	39	half	half	NN
cord-269011-230p8rsf	206	40	of	of	IN
cord-269011-230p8rsf	206	41	the	the	DT
cord-269011-230p8rsf	206	42	protein	protein	NN
cord-269011-230p8rsf	206	43	is	be	VBZ
cord-269011-230p8rsf	206	44	located	locate	VBN
cord-269011-230p8rsf	206	45	on	on	IN
cord-269011-230p8rsf	206	46	the	the	DT
cord-269011-230p8rsf	206	47	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	206	48	side	side	NN
cord-269011-230p8rsf	206	49	of	of	IN
cord-269011-230p8rsf	206	50	the	the	DT
cord-269011-230p8rsf	206	51	membrane	membrane	NN
cord-269011-230p8rsf	206	52	(	(	-LRB-
cord-269011-230p8rsf	206	53	or	or	CC
cord-269011-230p8rsf	206	54	inside	inside	IN
cord-269011-230p8rsf	206	55	the	the	DT
cord-269011-230p8rsf	206	56	virion	virion	NN
cord-269011-230p8rsf	206	57	)	)	-RRB-
cord-269011-230p8rsf	206	58	.	.	.
cord-269011-230p8rsf	207	1	In	in	IN
cord-269011-230p8rsf	207	2	TGEV	TGEV	NNP
cord-269011-230p8rsf	207	3	virions	virion	NNS
cord-269011-230p8rsf	207	4	some	some	DT
cord-269011-230p8rsf	207	5	of	of	IN
cord-269011-230p8rsf	207	6	the	the	DT
cord-269011-230p8rsf	207	7	M	M	NNP
cord-269011-230p8rsf	207	8	proteins	protein	NNS
cord-269011-230p8rsf	207	9	have	have	VBP
cord-269011-230p8rsf	207	10	their	-PRON-	PRP$
cord-269011-230p8rsf	207	11	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	207	12	tail	tail	NN
cord-269011-230p8rsf	207	13	exposed	expose	VBN
cord-269011-230p8rsf	207	14	on	on	IN
cord-269011-230p8rsf	207	15	the	the	DT
cord-269011-230p8rsf	207	16	outside	outside	NN
cord-269011-230p8rsf	207	17	(	(	-LRB-
cord-269011-230p8rsf	207	18	not	not	RB
cord-269011-230p8rsf	207	19	shown	show	VBN
cord-269011-230p8rsf	207	20	)	)	-RRB-
cord-269011-230p8rsf	207	21	.	.	.
cord-269011-230p8rsf	208	1	The	the	DT
cord-269011-230p8rsf	208	2	M	M	NNP
cord-269011-230p8rsf	208	3	protein	protein	NN
cord-269011-230p8rsf	208	4	is	be	VBZ
cord-269011-230p8rsf	208	5	glycosylated	glycosylate	VBN
cord-269011-230p8rsf	208	6	at	at	IN
cord-269011-230p8rsf	208	7	its	-PRON-	PRP$
cord-269011-230p8rsf	208	8	amino	amino	NN
cord-269011-230p8rsf	208	9	terminus	terminus	NN
cord-269011-230p8rsf	208	10	(	(	-LRB-
cord-269011-230p8rsf	208	11	indicated	indicate	VBN
cord-269011-230p8rsf	208	12	by	by	IN
cord-269011-230p8rsf	208	13	a	a	DT
cord-269011-230p8rsf	208	14	diamond	diamond	NN
cord-269011-230p8rsf	208	15	)	)	-RRB-
cord-269011-230p8rsf	208	16	.	.	.
cord-269011-230p8rsf	209	1	The	the	DT
cord-269011-230p8rsf	209	2	amphipathic	amphipathic	JJ
cord-269011-230p8rsf	209	3	domain	domain	NN
cord-269011-230p8rsf	209	4	of	of	IN
cord-269011-230p8rsf	209	5	the	the	DT
cord-269011-230p8rsf	209	6	M	M	NNP
cord-269011-230p8rsf	209	7	protein	protein	NN
cord-269011-230p8rsf	209	8	is	be	VBZ
cord-269011-230p8rsf	209	9	represented	represent	VBN
cord-269011-230p8rsf	209	10	by	by	IN
cord-269011-230p8rsf	209	11	an	an	DT
cord-269011-230p8rsf	209	12	oval	oval	NN
cord-269011-230p8rsf	209	13	.	.	.
cord-269011-230p8rsf	210	1	The	the	DT
cord-269011-230p8rsf	210	2	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	210	3	carboxy	carboxy	JJ
cord-269011-230p8rsf	210	4	terminus	terminus	NN
cord-269011-230p8rsf	210	5	of	of	IN
cord-269011-230p8rsf	210	6	the	the	DT
cord-269011-230p8rsf	210	7	E	e	NN
cord-269011-230p8rsf	210	8	protein	protein	NN
cord-269011-230p8rsf	210	9	is	be	VBZ
cord-269011-230p8rsf	210	10	exposed	expose	VBN
cord-269011-230p8rsf	210	11	on	on	IN
cord-269011-230p8rsf	210	12	the	the	DT
cord-269011-230p8rsf	210	13	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	210	14	side	side	NN
cord-269011-230p8rsf	210	15	of	of	IN
cord-269011-230p8rsf	210	16	cellular	cellular	JJ
cord-269011-230p8rsf	210	17	membranes	membrane	NNS
cord-269011-230p8rsf	210	18	or	or	CC
cord-269011-230p8rsf	210	19	on	on	IN
cord-269011-230p8rsf	210	20	the	the	DT
cord-269011-230p8rsf	210	21	inside	inside	NN
cord-269011-230p8rsf	210	22	of	of	IN
cord-269011-230p8rsf	210	23	the	the	DT
cord-269011-230p8rsf	210	24	virion	virion	NN
cord-269011-230p8rsf	210	25	.	.	.
cord-269011-230p8rsf	211	1	The	the	DT
cord-269011-230p8rsf	211	2	E	e	NN
cord-269011-230p8rsf	211	3	protein	protein	NN
cord-269011-230p8rsf	211	4	may	may	MD
cord-269011-230p8rsf	211	5	span	span	VB
cord-269011-230p8rsf	211	6	the	the	DT
cord-269011-230p8rsf	211	7	bilayer	bilayer	NN
cord-269011-230p8rsf	211	8	once	once	RB
cord-269011-230p8rsf	211	9	(	(	-LRB-
cord-269011-230p8rsf	211	10	b	b	NN
cord-269011-230p8rsf	211	11	)	)	-RRB-
cord-269011-230p8rsf	211	12	or	or	CC
cord-269011-230p8rsf	211	13	twice	twice	RB
cord-269011-230p8rsf	211	14	(	(	-LRB-
cord-269011-230p8rsf	211	15	a	a	NN
cord-269011-230p8rsf	211	16	)	)	-RRB-
cord-269011-230p8rsf	211	17	.	.	.
cord-269011-230p8rsf	212	1	M	M	NNP
cord-269011-230p8rsf	212	2	protein	protein	NN
cord-269011-230p8rsf	212	3	of	of	IN
cord-269011-230p8rsf	212	4	TGEV	TGEV	NNP
cord-269011-230p8rsf	212	5	was	be	VBD
cord-269011-230p8rsf	212	6	shown	show	VBN
cord-269011-230p8rsf	212	7	to	to	TO
cord-269011-230p8rsf	212	8	adopt	adopt	VB
cord-269011-230p8rsf	212	9	an	an	DT
cord-269011-230p8rsf	212	10	additional	additional	JJ
cord-269011-230p8rsf	212	11	conformation	conformation	NN
cord-269011-230p8rsf	212	12	.	.	.
cord-269011-230p8rsf	213	1	In	in	IN
cord-269011-230p8rsf	213	2	virions	virion	NNS
cord-269011-230p8rsf	213	3	about	about	IN
cord-269011-230p8rsf	213	4	one	one	CD
cord-269011-230p8rsf	213	5	-	-	HYPH
cord-269011-230p8rsf	213	6	third	third	NN
cord-269011-230p8rsf	213	7	of	of	IN
cord-269011-230p8rsf	213	8	the	the	DT
cord-269011-230p8rsf	213	9	M	M	NNP
cord-269011-230p8rsf	213	10	molecules	molecule	NNS
cord-269011-230p8rsf	213	11	have	have	VBP
cord-269011-230p8rsf	213	12	their	-PRON-	PRP$
cord-269011-230p8rsf	213	13	carboxy	carboxy	JJ
cord-269011-230p8rsf	213	14	terminus	terminus	NN
cord-269011-230p8rsf	213	15	exposed	expose	VBN
cord-269011-230p8rsf	213	16	on	on	IN
cord-269011-230p8rsf	213	17	the	the	DT
cord-269011-230p8rsf	213	18	virus	virus	NN
cord-269011-230p8rsf	213	19	surface	surface	NN
cord-269011-230p8rsf	213	20	rather	rather	RB
cord-269011-230p8rsf	213	21	than	than	IN
cord-269011-230p8rsf	213	22	buried	bury	VBN
cord-269011-230p8rsf	213	23	inside	inside	IN
cord-269011-230p8rsf	213	24	the	the	DT
cord-269011-230p8rsf	213	25	particle	particle	NN
cord-269011-230p8rsf	213	26	(	(	-LRB-
cord-269011-230p8rsf	213	27	Escors	Escors	NNP
cord-269011-230p8rsf	213	28	et	et	NNP
cord-269011-230p8rsf	213	29	al	al	NNP
cord-269011-230p8rsf	213	30	.	.	NNP
cord-269011-230p8rsf	213	31	,	,	,
cord-269011-230p8rsf	213	32	2001a	2001a	CD
cord-269011-230p8rsf	213	33	;	;	:
cord-269011-230p8rsf	213	34	Risco	Risco	NNP
cord-269011-230p8rsf	213	35	et	et	NNP
cord-269011-230p8rsf	213	36	al	al	NNP
cord-269011-230p8rsf	213	37	.	.	NNP
cord-269011-230p8rsf	213	38	,	,	,
cord-269011-230p8rsf	213	39	1995	1995	CD
cord-269011-230p8rsf	213	40	)	)	-RRB-
cord-269011-230p8rsf	213	41	.	.	.
cord-269011-230p8rsf	214	1	This	this	DT
cord-269011-230p8rsf	214	2	appears	appear	VBZ
cord-269011-230p8rsf	214	3	to	to	TO
cord-269011-230p8rsf	214	4	have	have	VB
cord-269011-230p8rsf	214	5	immunological	immunological	JJ
cord-269011-230p8rsf	214	6	consequences	consequence	NNS
cord-269011-230p8rsf	214	7	(	(	-LRB-
cord-269011-230p8rsf	214	8	Risco	Risco	NNP
cord-269011-230p8rsf	214	9	et	et	NNP
cord-269011-230p8rsf	214	10	al	al	NNP
cord-269011-230p8rsf	214	11	.	.	NNP
cord-269011-230p8rsf	214	12	,	,	,
cord-269011-230p8rsf	214	13	1995	1995	CD
cord-269011-230p8rsf	214	14	)	)	-RRB-
cord-269011-230p8rsf	214	15	but	but	CC
cord-269011-230p8rsf	214	16	the	the	DT
cord-269011-230p8rsf	214	17	real	real	JJ
cord-269011-230p8rsf	214	18	significance	significance	NN
cord-269011-230p8rsf	214	19	of	of	IN
cord-269011-230p8rsf	214	20	the	the	DT
cord-269011-230p8rsf	214	21	dual	dual	JJ
cord-269011-230p8rsf	214	22	topology	topology	NN
cord-269011-230p8rsf	214	23	is	be	VBZ
cord-269011-230p8rsf	214	24	unclear	unclear	JJ
cord-269011-230p8rsf	214	25	.	.	.
cord-269011-230p8rsf	215	1	In	in	IN
cord-269011-230p8rsf	215	2	MHV	MHV	NNP
cord-269011-230p8rsf	215	3	the	the	DT
cord-269011-230p8rsf	215	4	M	M	NNP
cord-269011-230p8rsf	215	5	protein	protein	NN
cord-269011-230p8rsf	215	6	was	be	VBD
cord-269011-230p8rsf	215	7	found	find	VBN
cord-269011-230p8rsf	215	8	to	to	TO
cord-269011-230p8rsf	215	9	assume	assume	VB
cord-269011-230p8rsf	215	10	only	only	RB
cord-269011-230p8rsf	215	11	one	one	CD
cord-269011-230p8rsf	215	12	defined	define	VBN
cord-269011-230p8rsf	215	13	membrane	membrane	NN
cord-269011-230p8rsf	215	14	topology	topology	NN
cord-269011-230p8rsf	215	15	.	.	.
cord-269011-230p8rsf	216	1	The	the	DT
cord-269011-230p8rsf	216	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	216	3	M	M	NNP
cord-269011-230p8rsf	216	4	protein	protein	NN
cord-269011-230p8rsf	216	5	is	be	VBZ
cord-269011-230p8rsf	216	6	almost	almost	RB
cord-269011-230p8rsf	216	7	invariably	invariably	RB
cord-269011-230p8rsf	216	8	glycosylated	glycosylate	VBN
cord-269011-230p8rsf	216	9	in	in	IN
cord-269011-230p8rsf	216	10	its	-PRON-	PRP$
cord-269011-230p8rsf	216	11	exposed	expose	VBN
cord-269011-230p8rsf	216	12	amino	amino	NN
cord-269011-230p8rsf	216	13	-	-	HYPH
cord-269011-230p8rsf	216	14	terminal	terminal	NN
cord-269011-230p8rsf	216	15	domain	domain	NN
cord-269011-230p8rsf	216	16	.	.	.
cord-269011-230p8rsf	217	1	This	this	DT
cord-269011-230p8rsf	217	2	provides	provide	VBZ
cord-269011-230p8rsf	217	3	the	the	DT
cord-269011-230p8rsf	217	4	virion	virion	NN
cord-269011-230p8rsf	217	5	with	with	IN
cord-269011-230p8rsf	217	6	a	a	DT
cord-269011-230p8rsf	217	7	diffuse	diffuse	JJ
cord-269011-230p8rsf	217	8	,	,	,
cord-269011-230p8rsf	217	9	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	217	10	cover	cover	NN
cord-269011-230p8rsf	217	11	on	on	IN
cord-269011-230p8rsf	217	12	its	-PRON-	PRP$
cord-269011-230p8rsf	217	13	outer	outer	JJ
cord-269011-230p8rsf	217	14	surface	surface	NN
cord-269011-230p8rsf	217	15	.	.	.
cord-269011-230p8rsf	218	1	Whereas	whereas	IN
cord-269011-230p8rsf	218	2	the	the	DT
cord-269011-230p8rsf	218	3	group	group	NN
cord-269011-230p8rsf	218	4	1	1	CD
cord-269011-230p8rsf	218	5	and	and	CC
cord-269011-230p8rsf	218	6	3	3	CD
cord-269011-230p8rsf	218	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	218	8	and	and	CC
cord-269011-230p8rsf	218	9	SARS	SARS	NNP
cord-269011-230p8rsf	218	10	-	-	HYPH
cord-269011-230p8rsf	218	11	CoV	CoV	NNP
cord-269011-230p8rsf	218	12	all	all	DT
cord-269011-230p8rsf	218	13	contain	contain	VBP
cord-269011-230p8rsf	218	14	M	M	NNP
cord-269011-230p8rsf	218	15	proteins	protein	NNS
cord-269011-230p8rsf	218	16	with	with	IN
cord-269011-230p8rsf	218	17	only	only	RB
cord-269011-230p8rsf	218	18	N	n	CD
cord-269011-230p8rsf	218	19	-	-	HYPH
cord-269011-230p8rsf	218	20	linked	link	VBN
cord-269011-230p8rsf	218	21	sugars	sugar	NNS
cord-269011-230p8rsf	218	22	,	,	,
cord-269011-230p8rsf	219	1	the	the	DT
cord-269011-230p8rsf	219	2	M	M	NNP
cord-269011-230p8rsf	219	3	proteins	protein	NNS
cord-269011-230p8rsf	219	4	of	of	IN
cord-269011-230p8rsf	219	5	group	group	NN
cord-269011-230p8rsf	219	6	2	2	CD
cord-269011-230p8rsf	219	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	219	8	are	be	VBP
cord-269011-230p8rsf	219	9	O	o	NN
cord-269011-230p8rsf	219	10	-	-	HYPH
cord-269011-230p8rsf	219	11	glycosylated	glycosylated	JJ
cord-269011-230p8rsf	219	12	(	(	-LRB-
cord-269011-230p8rsf	219	13	for	for	IN
cord-269011-230p8rsf	219	14	a	a	DT
cord-269011-230p8rsf	219	15	review	review	NN
cord-269011-230p8rsf	219	16	see	see	VB
cord-269011-230p8rsf	219	17	Rottier	Rottier	NNP
cord-269011-230p8rsf	219	18	,	,	,
cord-269011-230p8rsf	219	19	1995	1995	CD
cord-269011-230p8rsf	219	20	)	)	-RRB-
cord-269011-230p8rsf	219	21	.	.	.
cord-269011-230p8rsf	220	1	An	an	DT
cord-269011-230p8rsf	220	2	exception	exception	NN
cord-269011-230p8rsf	220	3	is	be	VBZ
cord-269011-230p8rsf	220	4	MHV-2	MHV-2	NNP
cord-269011-230p8rsf	220	5	,	,	,
cord-269011-230p8rsf	220	6	the	the	DT
cord-269011-230p8rsf	220	7	M	M	NNP
cord-269011-230p8rsf	220	8	protein	protein	NN
cord-269011-230p8rsf	220	9	of	of	IN
cord-269011-230p8rsf	220	10	which	which	WDT
cord-269011-230p8rsf	220	11	carries	carry	VBZ
cord-269011-230p8rsf	220	12	both	both	DT
cord-269011-230p8rsf	220	13	O	O	NNP
cord-269011-230p8rsf	220	14	-	-	HYPH
cord-269011-230p8rsf	220	15	and	and	CC
cord-269011-230p8rsf	220	16	N	n	NN
cord-269011-230p8rsf	220	17	-	-	HYPH
cord-269011-230p8rsf	220	18	linked	link	VBN
cord-269011-230p8rsf	220	19	sugars	sugar	NNS
cord-269011-230p8rsf	220	20	(	(	-LRB-
cord-269011-230p8rsf	220	21	Yamada	Yamada	NNP
cord-269011-230p8rsf	220	22	et	et	FW
cord-269011-230p8rsf	220	23	al	al	NNP
cord-269011-230p8rsf	220	24	.	.	NNP
cord-269011-230p8rsf	220	25	,	,	,
cord-269011-230p8rsf	220	26	2000	2000	CD
cord-269011-230p8rsf	220	27	)	)	-RRB-
cord-269011-230p8rsf	220	28	.	.	.
cord-269011-230p8rsf	221	1	N	N	NNP
cord-269011-230p8rsf	221	2	-	-	HYPH
cord-269011-230p8rsf	221	3	Glycosylation	Glycosylation	NNP
cord-269011-230p8rsf	221	4	is	be	VBZ
cord-269011-230p8rsf	221	5	initiated	initiate	VBN
cord-269011-230p8rsf	221	6	in	in	IN
cord-269011-230p8rsf	221	7	the	the	DT
cord-269011-230p8rsf	221	8	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	221	9	reticulum	reticulum	NN
cord-269011-230p8rsf	221	10	by	by	IN
cord-269011-230p8rsf	221	11	the	the	DT
cord-269011-230p8rsf	221	12	cotranslational	cotranslational	JJ
cord-269011-230p8rsf	221	13	linkage	linkage	NN
cord-269011-230p8rsf	221	14	of	of	IN
cord-269011-230p8rsf	221	15	a	a	DT
cord-269011-230p8rsf	221	16	large	large	JJ
cord-269011-230p8rsf	221	17	oligosaccharide	oligosaccharide	NN
cord-269011-230p8rsf	221	18	structure	structure	NN
cord-269011-230p8rsf	221	19	to	to	IN
cord-269011-230p8rsf	221	20	the	the	DT
cord-269011-230p8rsf	221	21	polypeptide	polypeptide	NN
cord-269011-230p8rsf	221	22	at	at	IN
cord-269011-230p8rsf	221	23	asparagine	asparagine	NN
cord-269011-230p8rsf	221	24	residues	residue	NNS
cord-269011-230p8rsf	221	25	within	within	IN
cord-269011-230p8rsf	221	26	the	the	DT
cord-269011-230p8rsf	221	27	consensus	consensus	NN
cord-269011-230p8rsf	221	28	sequence	sequence	NN
cord-269011-230p8rsf	221	29	NXS	NXS	NNP
cord-269011-230p8rsf	221	30	/	/	SYM
cord-269011-230p8rsf	221	31	T	T	NNP
cord-269011-230p8rsf	221	32	(	(	-LRB-
cord-269011-230p8rsf	221	33	where	where	WRB
cord-269011-230p8rsf	221	34	X	x	NN
cord-269011-230p8rsf	221	35	is	be	VBZ
cord-269011-230p8rsf	221	36	any	any	DT
cord-269011-230p8rsf	221	37	amino	amino	NN
cord-269011-230p8rsf	221	38	acid	acid	NN
cord-269011-230p8rsf	221	39	)	)	-RRB-
cord-269011-230p8rsf	221	40	.	.	.
cord-269011-230p8rsf	222	1	In	in	IN
cord-269011-230p8rsf	222	2	contrast	contrast	NN
cord-269011-230p8rsf	222	3	,	,	,
cord-269011-230p8rsf	222	4	mucin	mucin	NN
cord-269011-230p8rsf	222	5	-	-	HYPH
cord-269011-230p8rsf	222	6	type	type	NN
cord-269011-230p8rsf	222	7	O	o	NN
cord-269011-230p8rsf	222	8	-	-	HYPH
cord-269011-230p8rsf	222	9	glycosylation	glycosylation	NN
cord-269011-230p8rsf	222	10	starts	start	NNS
cord-269011-230p8rsf	222	11	posttranslationally	posttranslationally	RB
cord-269011-230p8rsf	222	12	with	with	IN
cord-269011-230p8rsf	222	13	the	the	DT
cord-269011-230p8rsf	222	14	addition	addition	NN
cord-269011-230p8rsf	222	15	of	of	IN
cord-269011-230p8rsf	222	16	an	an	DT
cord-269011-230p8rsf	222	17	N	n	CD
cord-269011-230p8rsf	222	18	-	-	HYPH
cord-269011-230p8rsf	222	19	acetylgalactosamine	acetylgalactosamine	JJ
cord-269011-230p8rsf	222	20	(	(	-LRB-
cord-269011-230p8rsf	222	21	GalNAc	GalNAc	NNP
cord-269011-230p8rsf	222	22	)	)	-RRB-
cord-269011-230p8rsf	222	23	monosaccharide	monosaccharide	NN
cord-269011-230p8rsf	222	24	to	to	IN
cord-269011-230p8rsf	222	25	a	a	DT
cord-269011-230p8rsf	222	26	hydroxylamino	hydroxylamino	NN
cord-269011-230p8rsf	222	27	acid	acid	NN
cord-269011-230p8rsf	222	28	.	.	.
cord-269011-230p8rsf	223	1	O	o	UH
cord-269011-230p8rsf	223	2	-	-	HYPH
cord-269011-230p8rsf	223	3	Glycosylation	Glycosylation	NNP
cord-269011-230p8rsf	223	4	is	be	VBZ
cord-269011-230p8rsf	223	5	subsequently	subsequently	RB
cord-269011-230p8rsf	223	6	completed	complete	VBN
cord-269011-230p8rsf	223	7	by	by	IN
cord-269011-230p8rsf	223	8	stepwise	stepwise	JJ
cord-269011-230p8rsf	223	9	addition	addition	NN
cord-269011-230p8rsf	223	10	of	of	IN
cord-269011-230p8rsf	223	11	other	other	JJ
cord-269011-230p8rsf	223	12	monosaccharides	monosaccharide	NNS
cord-269011-230p8rsf	223	13	such	such	JJ
cord-269011-230p8rsf	223	14	as	as	IN
cord-269011-230p8rsf	223	15	galactose	galactose	NN
cord-269011-230p8rsf	223	16	,	,	,
cord-269011-230p8rsf	223	17	N	N	NNP
cord-269011-230p8rsf	223	18	-	-	HYPH
cord-269011-230p8rsf	223	19	acetylglucosamine	acetylglucosamine	NNP
cord-269011-230p8rsf	223	20	,	,	,
cord-269011-230p8rsf	223	21	fucose	fucose	NNP
cord-269011-230p8rsf	223	22	,	,	,
cord-269011-230p8rsf	223	23	and	and	CC
cord-269011-230p8rsf	223	24	sialic	sialic	JJ
cord-269011-230p8rsf	223	25	acid	acid	NN
cord-269011-230p8rsf	223	26	.	.	.
cord-269011-230p8rsf	224	1	MHV	MHV	NNP
cord-269011-230p8rsf	224	2	M	M	NNP
cord-269011-230p8rsf	224	3	proteins	protein	NNS
cord-269011-230p8rsf	224	4	carry	carry	VBP
cord-269011-230p8rsf	224	5	a	a	DT
cord-269011-230p8rsf	224	6	well	well	RB
cord-269011-230p8rsf	224	7	-	-	HYPH
cord-269011-230p8rsf	224	8	conserved	conserve	VBN
cord-269011-230p8rsf	224	9	SS(X)TTXXP	ss(x)ttxxp	JJ
cord-269011-230p8rsf	224	10	sequence	sequence	NN
cord-269011-230p8rsf	224	11	at	at	IN
cord-269011-230p8rsf	224	12	their	-PRON-	PRP$
cord-269011-230p8rsf	224	13	extreme	extreme	JJ
cord-269011-230p8rsf	224	14	amino	amino	NN
cord-269011-230p8rsf	224	15	terminus	terminus	NN
cord-269011-230p8rsf	224	16	.	.	.
cord-269011-230p8rsf	225	1	Despite	despite	IN
cord-269011-230p8rsf	225	2	the	the	DT
cord-269011-230p8rsf	225	3	apparent	apparent	JJ
cord-269011-230p8rsf	225	4	presence	presence	NN
cord-269011-230p8rsf	225	5	of	of	IN
cord-269011-230p8rsf	225	6	multiple	multiple	JJ
cord-269011-230p8rsf	225	7	hydroxylamino	hydroxylamino	NN
cord-269011-230p8rsf	225	8	acids	acid	NNS
cord-269011-230p8rsf	225	9	as	as	IN
cord-269011-230p8rsf	225	10	potential	potential	JJ
cord-269011-230p8rsf	225	11	oligosaccharide	oligosaccharide	NN
cord-269011-230p8rsf	225	12	acceptor	acceptor	NN
cord-269011-230p8rsf	225	13	sites	site	NNS
cord-269011-230p8rsf	225	14	the	the	DT
cord-269011-230p8rsf	225	15	M	M	NNP
cord-269011-230p8rsf	225	16	protein	protein	NN
cord-269011-230p8rsf	225	17	of	of	IN
cord-269011-230p8rsf	225	18	MHV	MHV	NNP
cord-269011-230p8rsf	225	19	-	-	HYPH
cord-269011-230p8rsf	225	20	A59	A59	NNP
cord-269011-230p8rsf	225	21	was	be	VBD
cord-269011-230p8rsf	225	22	found	find	VBN
cord-269011-230p8rsf	225	23	to	to	TO
cord-269011-230p8rsf	225	24	be	be	VB
cord-269011-230p8rsf	225	25	modified	modify	VBN
cord-269011-230p8rsf	225	26	by	by	IN
cord-269011-230p8rsf	225	27	the	the	DT
cord-269011-230p8rsf	225	28	addition	addition	NN
cord-269011-230p8rsf	225	29	of	of	IN
cord-269011-230p8rsf	225	30	only	only	RB
cord-269011-230p8rsf	225	31	a	a	DT
cord-269011-230p8rsf	225	32	single	single	JJ
cord-269011-230p8rsf	225	33	oligosaccharide	oligosaccharide	NN
cord-269011-230p8rsf	225	34	side	side	NN
cord-269011-230p8rsf	225	35	chain	chain	NN
cord-269011-230p8rsf	225	36	(	(	-LRB-
cord-269011-230p8rsf	225	37	de	de	FW
cord-269011-230p8rsf	225	38	Haan	Haan	NNP
cord-269011-230p8rsf	225	39	et	et	FW
cord-269011-230p8rsf	225	40	al	al	NNP
cord-269011-230p8rsf	225	41	.	.	NNP
cord-269011-230p8rsf	225	42	,	,	,
cord-269011-230p8rsf	225	43	1998b	1998b	CD
cord-269011-230p8rsf	225	44	)	)	-RRB-
cord-269011-230p8rsf	225	45	.	.	.
cord-269011-230p8rsf	226	1	This	this	DT
cord-269011-230p8rsf	226	2	side	side	NN
cord-269011-230p8rsf	226	3	chain	chain	NN
cord-269011-230p8rsf	226	4	,	,	,
cord-269011-230p8rsf	226	5	when	when	WRB
cord-269011-230p8rsf	226	6	studied	study	VBN
cord-269011-230p8rsf	226	7	in	in	IN
cord-269011-230p8rsf	226	8	OST7	OST7	NNP
cord-269011-230p8rsf	226	9	-	-	HYPH
cord-269011-230p8rsf	226	10	1	1	CD
cord-269011-230p8rsf	226	11	cells	cell	NNS
cord-269011-230p8rsf	226	12	,	,	,
cord-269011-230p8rsf	226	13	appeared	appear	VBD
cord-269011-230p8rsf	226	14	to	to	TO
cord-269011-230p8rsf	226	15	be	be	VB
cord-269011-230p8rsf	226	16	attached	attach	VBN
cord-269011-230p8rsf	226	17	to	to	IN
cord-269011-230p8rsf	226	18	the	the	DT
cord-269011-230p8rsf	226	19	threonine	threonine	NN
cord-269011-230p8rsf	226	20	at	at	IN
cord-269011-230p8rsf	226	21	position	position	NN
cord-269011-230p8rsf	226	22	5	5	CD
cord-269011-230p8rsf	226	23	.	.	.
cord-269011-230p8rsf	227	1	Mutation	mutation	NN
cord-269011-230p8rsf	227	2	studies	study	NNS
cord-269011-230p8rsf	227	3	,	,	,
cord-269011-230p8rsf	227	4	however	however	RB
cord-269011-230p8rsf	227	5	,	,	,
cord-269011-230p8rsf	227	6	revealed	reveal	VBD
cord-269011-230p8rsf	227	7	that	that	IN
cord-269011-230p8rsf	227	8	alternative	alternative	JJ
cord-269011-230p8rsf	227	9	acceptor	acceptor	NN
cord-269011-230p8rsf	227	10	sites	site	NNS
cord-269011-230p8rsf	227	11	can	can	MD
cord-269011-230p8rsf	227	12	also	also	RB
cord-269011-230p8rsf	227	13	be	be	VB
cord-269011-230p8rsf	227	14	used	use	VBN
cord-269011-230p8rsf	227	15	.	.	.
cord-269011-230p8rsf	228	1	No	no	DT
cord-269011-230p8rsf	228	2	unique	unique	JJ
cord-269011-230p8rsf	228	3	sequence	sequence	NN
cord-269011-230p8rsf	228	4	motifs	motif	NNS
cord-269011-230p8rsf	228	5	for	for	IN
cord-269011-230p8rsf	228	6	O	o	NN
cord-269011-230p8rsf	228	7	-	-	HYPH
cord-269011-230p8rsf	228	8	glycosylation	glycosylation	NN
cord-269011-230p8rsf	228	9	of	of	IN
cord-269011-230p8rsf	228	10	MHV	MHV	NNP
cord-269011-230p8rsf	228	11	M	M	NNP
cord-269011-230p8rsf	228	12	could	could	MD
cord-269011-230p8rsf	228	13	be	be	VB
cord-269011-230p8rsf	228	14	identified	identify	VBN
cord-269011-230p8rsf	228	15	,	,	,
cord-269011-230p8rsf	228	16	which	which	WDT
cord-269011-230p8rsf	228	17	is	be	VBZ
cord-269011-230p8rsf	228	18	probably	probably	RB
cord-269011-230p8rsf	228	19	related	relate	VBN
cord-269011-230p8rsf	228	20	to	to	IN
cord-269011-230p8rsf	228	21	the	the	DT
cord-269011-230p8rsf	228	22	occurrence	occurrence	NN
cord-269011-230p8rsf	228	23	in	in	IN
cord-269011-230p8rsf	228	24	cells	cell	NNS
cord-269011-230p8rsf	228	25	of	of	IN
cord-269011-230p8rsf	228	26	multiple	multiple	JJ
cord-269011-230p8rsf	228	27	GalNAc	galnac	NN
cord-269011-230p8rsf	228	28	transferases	transferase	NNS
cord-269011-230p8rsf	228	29	(	(	-LRB-
cord-269011-230p8rsf	228	30	de	de	FW
cord-269011-230p8rsf	228	31	Haan	Haan	NNP
cord-269011-230p8rsf	228	32	et	et	FW
cord-269011-230p8rsf	228	33	al	al	NNP
cord-269011-230p8rsf	228	34	.	.	NNP
cord-269011-230p8rsf	228	35	,	,	,
cord-269011-230p8rsf	228	36	1998b	1998b	CD
cord-269011-230p8rsf	228	37	)	)	-RRB-
cord-269011-230p8rsf	228	38	.	.	.
cord-269011-230p8rsf	229	1	As	as	IN
cord-269011-230p8rsf	229	2	the	the	DT
cord-269011-230p8rsf	229	3	expression	expression	NN
cord-269011-230p8rsf	229	4	of	of	IN
cord-269011-230p8rsf	229	5	these	these	DT
cord-269011-230p8rsf	229	6	enzymes	enzyme	NNS
cord-269011-230p8rsf	229	7	varies	vary	VBZ
cord-269011-230p8rsf	229	8	in	in	IN
cord-269011-230p8rsf	229	9	cells	cell	NNS
cord-269011-230p8rsf	229	10	,	,	,
cord-269011-230p8rsf	229	11	conservation	conservation	NN
cord-269011-230p8rsf	229	12	of	of	IN
cord-269011-230p8rsf	229	13	the	the	DT
cord-269011-230p8rsf	229	14	SS(X)TTXXP	ss(x)ttxxp	NN
cord-269011-230p8rsf	229	15	motif	motif	NN
cord-269011-230p8rsf	229	16	in	in	IN
cord-269011-230p8rsf	229	17	MHV	MHV	NNP
cord-269011-230p8rsf	229	18	M	M	NNP
cord-269011-230p8rsf	229	19	protein	protein	NN
cord-269011-230p8rsf	229	20	may	may	MD
cord-269011-230p8rsf	229	21	serve	serve	VB
cord-269011-230p8rsf	229	22	to	to	TO
cord-269011-230p8rsf	229	23	increase	increase	VB
cord-269011-230p8rsf	229	24	opportunities	opportunity	NNS
cord-269011-230p8rsf	229	25	for	for	IN
cord-269011-230p8rsf	229	26	the	the	DT
cord-269011-230p8rsf	229	27	protein	protein	NN
cord-269011-230p8rsf	229	28	to	to	TO
cord-269011-230p8rsf	229	29	become	become	VB
cord-269011-230p8rsf	229	30	glycosylated	glycosylate	VBN
cord-269011-230p8rsf	229	31	in	in	IN
cord-269011-230p8rsf	229	32	different	different	JJ
cord-269011-230p8rsf	229	33	cell	cell	NN
cord-269011-230p8rsf	229	34	types	type	NNS
cord-269011-230p8rsf	229	35	.	.	.
cord-269011-230p8rsf	230	1	The	the	DT
cord-269011-230p8rsf	230	2	distinct	distinct	JJ
cord-269011-230p8rsf	230	3	conservation	conservation	NN
cord-269011-230p8rsf	230	4	of	of	IN
cord-269011-230p8rsf	230	5	N	n	CD
cord-269011-230p8rsf	230	6	-	-	:
cord-269011-230p8rsf	230	7	and	and	CC
cord-269011-230p8rsf	230	8	O	o	NN
cord-269011-230p8rsf	230	9	-	-	HYPH
cord-269011-230p8rsf	230	10	glycosylation	glycosylation	NN
cord-269011-230p8rsf	230	11	among	among	IN
cord-269011-230p8rsf	230	12	the	the	DT
cord-269011-230p8rsf	230	13	M	M	NNP
cord-269011-230p8rsf	230	14	proteins	protein	NNS
cord-269011-230p8rsf	230	15	of	of	IN
cord-269011-230p8rsf	230	16	the	the	DT
cord-269011-230p8rsf	230	17	different	different	JJ
cord-269011-230p8rsf	230	18	groups	group	NNS
cord-269011-230p8rsf	230	19	of	of	IN
cord-269011-230p8rsf	230	20	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	230	21	suggests	suggest	VBZ
cord-269011-230p8rsf	230	22	that	that	IN
cord-269011-230p8rsf	230	23	the	the	DT
cord-269011-230p8rsf	230	24	presence	presence	NN
cord-269011-230p8rsf	230	25	and	and	CC
cord-269011-230p8rsf	230	26	the	the	DT
cord-269011-230p8rsf	230	27	particular	particular	JJ
cord-269011-230p8rsf	230	28	type	type	NN
cord-269011-230p8rsf	230	29	of	of	IN
cord-269011-230p8rsf	230	30	carbohydrates	carbohydrate	NNS
cord-269011-230p8rsf	230	31	are	be	VBP
cord-269011-230p8rsf	230	32	somehow	somehow	RB
cord-269011-230p8rsf	230	33	beneficial	beneficial	JJ
cord-269011-230p8rsf	230	34	to	to	IN
cord-269011-230p8rsf	230	35	the	the	DT
cord-269011-230p8rsf	230	36	virus	virus	NN
cord-269011-230p8rsf	230	37	,	,	,
cord-269011-230p8rsf	230	38	most	most	RBS
cord-269011-230p8rsf	230	39	likely	likely	JJ
cord-269011-230p8rsf	230	40	in	in	IN
cord-269011-230p8rsf	230	41	its	-PRON-	PRP$
cord-269011-230p8rsf	230	42	interaction	interaction	NN
cord-269011-230p8rsf	230	43	with	with	IN
cord-269011-230p8rsf	230	44	the	the	DT
cord-269011-230p8rsf	230	45	host	host	NN
cord-269011-230p8rsf	230	46	.	.	.
cord-269011-230p8rsf	231	1	Glycosylation	glycosylation	NN
cord-269011-230p8rsf	231	2	of	of	IN
cord-269011-230p8rsf	231	3	the	the	DT
cord-269011-230p8rsf	231	4	M	M	NNP
cord-269011-230p8rsf	231	5	protein	protein	NN
cord-269011-230p8rsf	231	6	appeared	appear	VBD
cord-269011-230p8rsf	231	7	not	not	RB
cord-269011-230p8rsf	231	8	to	to	TO
cord-269011-230p8rsf	231	9	be	be	VB
cord-269011-230p8rsf	231	10	required	require	VBN
cord-269011-230p8rsf	231	11	for	for	IN
cord-269011-230p8rsf	231	12	envelope	envelope	NN
cord-269011-230p8rsf	231	13	assembly	assembly	NNP
cord-269011-230p8rsf	231	14	(	(	-LRB-
cord-269011-230p8rsf	231	15	de	de	FW
cord-269011-230p8rsf	231	16	Haan	Haan	NNP
cord-269011-230p8rsf	231	17	et	et	FW
cord-269011-230p8rsf	231	18	al	al	NNP
cord-269011-230p8rsf	231	19	.	.	NNP
cord-269011-230p8rsf	231	20	,	,	,
cord-269011-230p8rsf	231	21	1998a	1998a	CD
cord-269011-230p8rsf	231	22	,	,	,
cord-269011-230p8rsf	231	23	)	)	-RRB-
cord-269011-230p8rsf	231	24	or	or	CC
cord-269011-230p8rsf	231	25	for	for	IN
cord-269011-230p8rsf	231	26	interaction	interaction	NN
cord-269011-230p8rsf	231	27	with	with	IN
cord-269011-230p8rsf	231	28	the	the	DT
cord-269011-230p8rsf	231	29	S	S	NNP
cord-269011-230p8rsf	231	30	protein	protein	NN
cord-269011-230p8rsf	231	31	(	(	-LRB-
cord-269011-230p8rsf	231	32	de	de	FW
cord-269011-230p8rsf	231	33	Haan	Haan	NNP
cord-269011-230p8rsf	231	34	et	et	FW
cord-269011-230p8rsf	231	35	al	al	NNP
cord-269011-230p8rsf	231	36	.	.	NNP
cord-269011-230p8rsf	231	37	,	,	,
cord-269011-230p8rsf	231	38	1999	1999	CD
cord-269011-230p8rsf	231	39	)	)	-RRB-
cord-269011-230p8rsf	231	40	,	,	,
cord-269011-230p8rsf	231	41	nor	nor	CC
cord-269011-230p8rsf	231	42	did	do	VBD
cord-269011-230p8rsf	231	43	it	-PRON-	PRP
cord-269011-230p8rsf	231	44	influence	influence	VB
cord-269011-230p8rsf	231	45	virus	virus	NN
cord-269011-230p8rsf	231	46	replication	replication	NN
cord-269011-230p8rsf	231	47	in	in	IN
cord-269011-230p8rsf	231	48	vitro	vitro	FW
cord-269011-230p8rsf	231	49	(	(	-LRB-
cord-269011-230p8rsf	231	50	de	de	FW
cord-269011-230p8rsf	231	51	Haan	Haan	NNP
cord-269011-230p8rsf	231	52	et	et	FW
cord-269011-230p8rsf	231	53	al	al	NNP
cord-269011-230p8rsf	231	54	.	.	.
cord-269011-230p8rsf	232	1	,	,	,
cord-269011-230p8rsf	232	2	2002a	2002a	CD
cord-269011-230p8rsf	232	3	Laude	Laude	NNP
cord-269011-230p8rsf	232	4	et	et	FW
cord-269011-230p8rsf	232	5	al	al	NNP
cord-269011-230p8rsf	232	6	.	.	NNP
cord-269011-230p8rsf	232	7	,	,	,
cord-269011-230p8rsf	232	8	1992	1992	CD
cord-269011-230p8rsf	232	9	)	)	-RRB-
cord-269011-230p8rsf	232	10	.	.	.
cord-269011-230p8rsf	233	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	233	2	are	be	VBP
cord-269011-230p8rsf	233	3	able	able	JJ
cord-269011-230p8rsf	233	4	to	to	TO
cord-269011-230p8rsf	233	5	induce	induce	VB
cord-269011-230p8rsf	233	6	interferon	interferon	NN
cord-269011-230p8rsf	233	7	a	a	DT
cord-269011-230p8rsf	233	8	(	(	-LRB-
cord-269011-230p8rsf	233	9	IFN	IFN	NNP
cord-269011-230p8rsf	233	10	-	-	HYPH
cord-269011-230p8rsf	233	11	a	a	LS
cord-269011-230p8rsf	233	12	)	)	-RRB-
cord-269011-230p8rsf	233	13	by	by	IN
cord-269011-230p8rsf	233	14	their	-PRON-	PRP$
cord-269011-230p8rsf	233	15	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	233	16	(	(	-LRB-
cord-269011-230p8rsf	233	17	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	233	18	et	et	NNP
cord-269011-230p8rsf	233	19	al	al	NNP
cord-269011-230p8rsf	233	20	.	.	NNP
cord-269011-230p8rsf	233	21	,	,	,
cord-269011-230p8rsf	233	22	1998a	1998a	CD
cord-269011-230p8rsf	233	23	,	,	,
cord-269011-230p8rsf	233	24	b	b	LS
cord-269011-230p8rsf	233	25	)	)	-RRB-
cord-269011-230p8rsf	233	26	.	.	.
cord-269011-230p8rsf	234	1	For	for	IN
cord-269011-230p8rsf	234	2	TGEV	TGEV	NNP
cord-269011-230p8rsf	234	3	(	(	-LRB-
cord-269011-230p8rsf	234	4	Charley	Charley	NNP
cord-269011-230p8rsf	234	5	and	and	CC
cord-269011-230p8rsf	234	6	Laude	Laude	NNP
cord-269011-230p8rsf	234	7	,	,	,
cord-269011-230p8rsf	234	8	1988	1988	CD
cord-269011-230p8rsf	234	9	;	;	:
cord-269011-230p8rsf	234	10	Laude	Laude	NNP
cord-269011-230p8rsf	234	11	et	et	NNP
cord-269011-230p8rsf	234	12	al	al	NNP
cord-269011-230p8rsf	234	13	.	.	NNP
cord-269011-230p8rsf	234	14	,	,	,
cord-269011-230p8rsf	234	15	1992	1992	CD
cord-269011-230p8rsf	234	16	)	)	-RRB-
cord-269011-230p8rsf	234	17	and	and	CC
cord-269011-230p8rsf	234	18	MHV	MHV	NNP
cord-269011-230p8rsf	234	19	(	(	-LRB-
cord-269011-230p8rsf	234	20	de	de	FW
cord-269011-230p8rsf	234	21	Haan	Haan	NNP
cord-269011-230p8rsf	234	22	et	et	FW
cord-269011-230p8rsf	234	23	al	al	NNP
cord-269011-230p8rsf	234	24	.	.	NNP
cord-269011-230p8rsf	234	25	,	,	,
cord-269011-230p8rsf	234	26	2003	2003	CD
cord-269011-230p8rsf	234	27	)	)	-RRB-
cord-269011-230p8rsf	234	28	,	,	,
cord-269011-230p8rsf	234	29	the	the	DT
cord-269011-230p8rsf	234	30	oligosaccharides	oligosaccharide	NNS
cord-269011-230p8rsf	234	31	linked	link	VBN
cord-269011-230p8rsf	234	32	to	to	IN
cord-269011-230p8rsf	234	33	the	the	DT
cord-269011-230p8rsf	234	34	M	M	NNP
cord-269011-230p8rsf	234	35	protein	protein	NN
cord-269011-230p8rsf	234	36	were	be	VBD
cord-269011-230p8rsf	234	37	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	234	38	to	to	TO
cord-269011-230p8rsf	234	39	be	be	VB
cord-269011-230p8rsf	234	40	important	important	JJ
cord-269011-230p8rsf	234	41	for	for	IN
cord-269011-230p8rsf	234	42	efficient	efficient	JJ
cord-269011-230p8rsf	234	43	IFN	IFN	NNP
cord-269011-230p8rsf	234	44	induction	induction	NN
cord-269011-230p8rsf	234	45	in	in	IN
cord-269011-230p8rsf	234	46	vitro	vitro	FW
cord-269011-230p8rsf	234	47	.	.	.
cord-269011-230p8rsf	235	1	The	the	DT
cord-269011-230p8rsf	235	2	glycosylation	glycosylation	NN
cord-269011-230p8rsf	235	3	status	status	NN
cord-269011-230p8rsf	235	4	of	of	IN
cord-269011-230p8rsf	235	5	the	the	DT
cord-269011-230p8rsf	235	6	MHV	MHV	NNP
cord-269011-230p8rsf	235	7	M	M	NNP
cord-269011-230p8rsf	235	8	protein	protein	NN
cord-269011-230p8rsf	235	9	was	be	VBD
cord-269011-230p8rsf	235	10	found	find	VBN
cord-269011-230p8rsf	235	11	to	to	TO
cord-269011-230p8rsf	235	12	influence	influence	VB
cord-269011-230p8rsf	235	13	the	the	DT
cord-269011-230p8rsf	235	14	ability	ability	NN
cord-269011-230p8rsf	235	15	of	of	IN
cord-269011-230p8rsf	235	16	the	the	DT
cord-269011-230p8rsf	235	17	virus	virus	NN
cord-269011-230p8rsf	235	18	to	to	TO
cord-269011-230p8rsf	235	19	replicate	replicate	VB
cord-269011-230p8rsf	235	20	in	in	IN
cord-269011-230p8rsf	235	21	the	the	DT
cord-269011-230p8rsf	235	22	liver	liver	NN
cord-269011-230p8rsf	235	23	but	but	CC
cord-269011-230p8rsf	235	24	not	not	RB
cord-269011-230p8rsf	235	25	in	in	IN
cord-269011-230p8rsf	235	26	the	the	DT
cord-269011-230p8rsf	235	27	brain	brain	NN
cord-269011-230p8rsf	235	28	.	.	.
cord-269011-230p8rsf	236	1	Thus	thus	RB
cord-269011-230p8rsf	236	2	,	,	,
cord-269011-230p8rsf	236	3	viruses	virus	NNS
cord-269011-230p8rsf	236	4	with	with	IN
cord-269011-230p8rsf	236	5	N	n	CD
cord-269011-230p8rsf	236	6	-	-	HYPH
cord-269011-230p8rsf	236	7	glycosylated	glycosylated	JJ
cord-269011-230p8rsf	236	8	M	M	NNP
cord-269011-230p8rsf	236	9	proteins	protein	NNS
cord-269011-230p8rsf	236	10	replicated	replicate	VBN
cord-269011-230p8rsf	236	11	to	to	IN
cord-269011-230p8rsf	236	12	a	a	DT
cord-269011-230p8rsf	236	13	significantly	significantly	RB
cord-269011-230p8rsf	236	14	higher	high	JJR
cord-269011-230p8rsf	236	15	extent	extent	NN
cord-269011-230p8rsf	236	16	in	in	IN
cord-269011-230p8rsf	236	17	liver	liver	NN
cord-269011-230p8rsf	236	18	than	than	IN
cord-269011-230p8rsf	236	19	otherwise	otherwise	RB
cord-269011-230p8rsf	236	20	identical	identical	JJ
cord-269011-230p8rsf	236	21	viruses	virus	NNS
cord-269011-230p8rsf	236	22	carrying	carry	VBG
cord-269011-230p8rsf	236	23	O	o	NN
cord-269011-230p8rsf	236	24	-	-	HYPH
cord-269011-230p8rsf	236	25	glycosylated	glycosylated	JJ
cord-269011-230p8rsf	236	26	M	M	NNP
cord-269011-230p8rsf	236	27	proteins	protein	NNS
cord-269011-230p8rsf	236	28	.	.	.
cord-269011-230p8rsf	237	1	MHV	MHV	NNP
cord-269011-230p8rsf	237	2	with	with	IN
cord-269011-230p8rsf	237	3	unglycosylated	unglycosylated	NNP
cord-269011-230p8rsf	237	4	M	M	NNP
cord-269011-230p8rsf	237	5	proteins	protein	NNS
cord-269011-230p8rsf	237	6	replicated	replicate	VBN
cord-269011-230p8rsf	237	7	to	to	IN
cord-269011-230p8rsf	237	8	the	the	DT
cord-269011-230p8rsf	237	9	lowest	low	JJS
cord-269011-230p8rsf	237	10	extent	extent	NN
cord-269011-230p8rsf	237	11	.	.	.
cord-269011-230p8rsf	238	1	The	the	DT
cord-269011-230p8rsf	238	2	mechanism	mechanism	NN
cord-269011-230p8rsf	238	3	behind	behind	IN
cord-269011-230p8rsf	238	4	these	these	DT
cord-269011-230p8rsf	238	5	observations	observation	NNS
cord-269011-230p8rsf	238	6	remains	remain	VBZ
cord-269011-230p8rsf	238	7	to	to	TO
cord-269011-230p8rsf	238	8	be	be	VB
cord-269011-230p8rsf	238	9	elucidated	elucidate	VBN
cord-269011-230p8rsf	238	10	.	.	.
cord-269011-230p8rsf	239	1	When	when	WRB
cord-269011-230p8rsf	239	2	expressed	express	VBN
cord-269011-230p8rsf	239	3	in	in	IN
cord-269011-230p8rsf	239	4	cells	cell	NNS
cord-269011-230p8rsf	239	5	independently	independently	RB
cord-269011-230p8rsf	239	6	from	from	IN
cord-269011-230p8rsf	239	7	the	the	DT
cord-269011-230p8rsf	239	8	other	other	JJ
cord-269011-230p8rsf	239	9	viral	viral	JJ
cord-269011-230p8rsf	239	10	proteins	protein	NNS
cord-269011-230p8rsf	239	11	,	,	,
cord-269011-230p8rsf	239	12	the	the	DT
cord-269011-230p8rsf	239	13	M	M	NNP
cord-269011-230p8rsf	239	14	proteins	protein	NNS
cord-269011-230p8rsf	239	15	of	of	IN
cord-269011-230p8rsf	239	16	MHV	MHV	NNP
cord-269011-230p8rsf	239	17	,	,	,
cord-269011-230p8rsf	239	18	IBV	IBV	NNP
cord-269011-230p8rsf	239	19	,	,	,
cord-269011-230p8rsf	239	20	TGEV	TGEV	NNP
cord-269011-230p8rsf	239	21	,	,	,
cord-269011-230p8rsf	239	22	and	and	CC
cord-269011-230p8rsf	239	23	feline	feline	JJ
cord-269011-230p8rsf	239	24	coronavirus	coronavirus	NN
cord-269011-230p8rsf	240	1	(	(	-LRB-
cord-269011-230p8rsf	240	2	FCoV	FCoV	NNP
cord-269011-230p8rsf	240	3	)	)	-RRB-
cord-269011-230p8rsf	240	4	accumulate	accumulate	VBP
cord-269011-230p8rsf	240	5	in	in	IN
cord-269011-230p8rsf	240	6	the	the	DT
cord-269011-230p8rsf	240	7	Golgi	Golgi	NNP
cord-269011-230p8rsf	240	8	compartment	compartment	NN
cord-269011-230p8rsf	240	9	,	,	,
cord-269011-230p8rsf	240	10	that	that	RB
cord-269011-230p8rsf	240	11	is	is	RB
cord-269011-230p8rsf	240	12	,	,	,
cord-269011-230p8rsf	240	13	beyond	beyond	IN
cord-269011-230p8rsf	240	14	the	the	DT
cord-269011-230p8rsf	240	15	site	site	NN
cord-269011-230p8rsf	240	16	of	of	IN
cord-269011-230p8rsf	240	17	virus	virus	NN
cord-269011-230p8rsf	240	18	budding	bud	VBG
cord-269011-230p8rsf	240	19	Locker	Locker	NNP
cord-269011-230p8rsf	240	20	et	et	FW
cord-269011-230p8rsf	240	21	al	al	NNP
cord-269011-230p8rsf	240	22	.	.	NNP
cord-269011-230p8rsf	240	23	,	,	,
cord-269011-230p8rsf	240	24	1992	1992	CD
cord-269011-230p8rsf	240	25	;	;	:
cord-269011-230p8rsf	240	26	Machamer	Machamer	NNP
cord-269011-230p8rsf	240	27	and	and	CC
cord-269011-230p8rsf	240	28	Rose	Rose	NNP
cord-269011-230p8rsf	240	29	,	,	,
cord-269011-230p8rsf	240	30	1987	1987	CD
cord-269011-230p8rsf	240	31	;	;	:
cord-269011-230p8rsf	240	32	Machamer	Machamer	NNP
cord-269011-230p8rsf	240	33	et	et	NNP
cord-269011-230p8rsf	240	34	al	al	NNP
cord-269011-230p8rsf	240	35	.	.	NNP
cord-269011-230p8rsf	240	36	,	,	,
cord-269011-230p8rsf	240	37	1990	1990	CD
cord-269011-230p8rsf	240	38	;	;	:
cord-269011-230p8rsf	240	39	Rottier	Rottier	NNP
cord-269011-230p8rsf	240	40	and	and	CC
cord-269011-230p8rsf	240	41	Rose	Rose	NNP
cord-269011-230p8rsf	240	42	,	,	,
cord-269011-230p8rsf	240	43	1987	1987	CD
cord-269011-230p8rsf	240	44	)	)	-RRB-
cord-269011-230p8rsf	240	45	,	,	,
cord-269011-230p8rsf	240	46	which	which	WDT
cord-269011-230p8rsf	240	47	is	be	VBZ
cord-269011-230p8rsf	240	48	the	the	DT
cord-269011-230p8rsf	240	49	intermediate	intermediate	JJ
cord-269011-230p8rsf	240	50	compartment	compartment	NN
cord-269011-230p8rsf	240	51	between	between	IN
cord-269011-230p8rsf	240	52	the	the	DT
cord-269011-230p8rsf	240	53	ER	ER	NNP
cord-269011-230p8rsf	240	54	and	and	CC
cord-269011-230p8rsf	240	55	the	the	DT
cord-269011-230p8rsf	240	56	Golgi	Golgi	NNP
cord-269011-230p8rsf	240	57	(	(	-LRB-
cord-269011-230p8rsf	240	58	ERGIC	ERGIC	NNP
cord-269011-230p8rsf	240	59	)	)	-RRB-
cord-269011-230p8rsf	240	60	.	.	.
cord-269011-230p8rsf	241	1	The	the	DT
cord-269011-230p8rsf	241	2	fine	fine	JJ
cord-269011-230p8rsf	241	3	localization	localization	NN
cord-269011-230p8rsf	241	4	of	of	IN
cord-269011-230p8rsf	241	5	the	the	DT
cord-269011-230p8rsf	241	6	different	different	JJ
cord-269011-230p8rsf	241	7	proteins	protein	NNS
cord-269011-230p8rsf	241	8	is	be	VBZ
cord-269011-230p8rsf	241	9	,	,	,
cord-269011-230p8rsf	241	10	however	however	RB
cord-269011-230p8rsf	241	11	,	,	,
cord-269011-230p8rsf	241	12	not	not	RB
cord-269011-230p8rsf	241	13	the	the	DT
cord-269011-230p8rsf	241	14	same	same	JJ
cord-269011-230p8rsf	241	15	.	.	.
cord-269011-230p8rsf	242	1	For	for	IN
cord-269011-230p8rsf	242	2	instance	instance	NN
cord-269011-230p8rsf	242	3	,	,	,
cord-269011-230p8rsf	242	4	whereas	whereas	IN
cord-269011-230p8rsf	242	5	the	the	DT
cord-269011-230p8rsf	242	6	MHV	MHV	NNP
cord-269011-230p8rsf	242	7	M	M	NNP
cord-269011-230p8rsf	242	8	protein	protein	NN
cord-269011-230p8rsf	242	9	is	be	VBZ
cord-269011-230p8rsf	242	10	concentrated	concentrate	VBN
cord-269011-230p8rsf	242	11	in	in	IN
cord-269011-230p8rsf	242	12	the	the	DT
cord-269011-230p8rsf	242	13	trans	trans	NN
cord-269011-230p8rsf	242	14	-	-	JJ
cord-269011-230p8rsf	242	15	most	most	JJS
cord-269011-230p8rsf	242	16	Golgi	Golgi	NNP
cord-269011-230p8rsf	242	17	compartments	compartment	NNS
cord-269011-230p8rsf	242	18	,	,	,
cord-269011-230p8rsf	242	19	the	the	DT
cord-269011-230p8rsf	242	20	IBV	IBV	NNP
cord-269011-230p8rsf	242	21	M	M	NNP
cord-269011-230p8rsf	242	22	protein	protein	NN
cord-269011-230p8rsf	242	23	localizes	localize	VBZ
cord-269011-230p8rsf	242	24	to	to	IN
cord-269011-230p8rsf	242	25	the	the	DT
cord-269011-230p8rsf	242	26	cis	cis	NNP
cord-269011-230p8rsf	242	27	side	side	NN
cord-269011-230p8rsf	242	28	of	of	IN
cord-269011-230p8rsf	242	29	the	the	DT
cord-269011-230p8rsf	242	30	Golgi	Golgi	NNP
cord-269011-230p8rsf	242	31	complex	complex	NN
cord-269011-230p8rsf	242	32	.	.	.
cord-269011-230p8rsf	243	1	Signals	signal	NNS
cord-269011-230p8rsf	243	2	for	for	IN
cord-269011-230p8rsf	243	3	localization	localization	NN
cord-269011-230p8rsf	243	4	appear	appear	VBP
cord-269011-230p8rsf	243	5	to	to	TO
cord-269011-230p8rsf	243	6	reside	reside	VB
cord-269011-230p8rsf	243	7	in	in	IN
cord-269011-230p8rsf	243	8	the	the	DT
cord-269011-230p8rsf	243	9	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	243	10	part	part	NN
cord-269011-230p8rsf	243	11	of	of	IN
cord-269011-230p8rsf	243	12	the	the	DT
cord-269011-230p8rsf	243	13	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	243	14	tail	tail	NN
cord-269011-230p8rsf	243	15	and	and	CC
cord-269011-230p8rsf	243	16	in	in	IN
cord-269011-230p8rsf	243	17	the	the	DT
cord-269011-230p8rsf	243	18	transmembrane	transmembrane	NN
cord-269011-230p8rsf	243	19	domains	domain	NNS
cord-269011-230p8rsf	243	20	.	.	.
cord-269011-230p8rsf	244	1	The	the	DT
cord-269011-230p8rsf	244	2	extreme	extreme	JJ
cord-269011-230p8rsf	244	3	carboxy	carboxy	JJ
cord-269011-230p8rsf	244	4	-	-	HYPH
cord-269011-230p8rsf	244	5	terminal	terminal	NN
cord-269011-230p8rsf	244	6	tail	tail	NN
cord-269011-230p8rsf	244	7	of	of	IN
cord-269011-230p8rsf	244	8	MHV	MHV	NNP
cord-269011-230p8rsf	244	9	M	M	NNP
cord-269011-230p8rsf	244	10	was	be	VBD
cord-269011-230p8rsf	244	11	shown	show	VBN
cord-269011-230p8rsf	244	12	to	to	TO
cord-269011-230p8rsf	244	13	be	be	VB
cord-269011-230p8rsf	244	14	necessary	necessary	JJ
cord-269011-230p8rsf	244	15	,	,	,
cord-269011-230p8rsf	244	16	although	although	IN
cord-269011-230p8rsf	244	17	not	not	RB
cord-269011-230p8rsf	244	18	sufficient	sufficient	JJ
cord-269011-230p8rsf	244	19	,	,	,
cord-269011-230p8rsf	244	20	for	for	IN
cord-269011-230p8rsf	244	21	Golgi	Golgi	NNP
cord-269011-230p8rsf	244	22	localization	localization	NN
cord-269011-230p8rsf	244	23	(	(	-LRB-
cord-269011-230p8rsf	244	24	Armstrong	Armstrong	NNP
cord-269011-230p8rsf	244	25	and	and	CC
cord-269011-230p8rsf	244	26	Patel	Patel	NNP
cord-269011-230p8rsf	244	27	,	,	,
cord-269011-230p8rsf	244	28	1991	1991	CD
cord-269011-230p8rsf	244	29	;	;	:
cord-269011-230p8rsf	244	30	Locker	Locker	NNP
cord-269011-230p8rsf	244	31	et	et	NNP
cord-269011-230p8rsf	244	32	al	al	NNP
cord-269011-230p8rsf	244	33	.	.	NNP
cord-269011-230p8rsf	244	34	,	,	,
cord-269011-230p8rsf	244	35	1994	1994	CD
cord-269011-230p8rsf	244	36	)	)	-RRB-
cord-269011-230p8rsf	244	37	.	.	.
cord-269011-230p8rsf	245	1	Mutant	mutant	JJ
cord-269011-230p8rsf	245	2	proteins	protein	NNS
cord-269011-230p8rsf	245	3	lacking	lack	VBG
cord-269011-230p8rsf	246	1	this	this	DT
cord-269011-230p8rsf	246	2	domain	domain	NN
cord-269011-230p8rsf	246	3	were	be	VBD
cord-269011-230p8rsf	246	4	transported	transport	VBN
cord-269011-230p8rsf	246	5	to	to	IN
cord-269011-230p8rsf	246	6	the	the	DT
cord-269011-230p8rsf	246	7	plasma	plasma	NN
cord-269011-230p8rsf	246	8	membrane	membrane	NN
cord-269011-230p8rsf	246	9	.	.	.
cord-269011-230p8rsf	247	1	Also	also	RB
cord-269011-230p8rsf	247	2	,	,	,
cord-269011-230p8rsf	247	3	mutation	mutation	NN
cord-269011-230p8rsf	247	4	of	of	IN
cord-269011-230p8rsf	247	5	a	a	DT
cord-269011-230p8rsf	247	6	single	single	JJ
cord-269011-230p8rsf	247	7	tyrosine	tyrosine	NN
cord-269011-230p8rsf	247	8	in	in	IN
cord-269011-230p8rsf	247	9	this	this	DT
cord-269011-230p8rsf	247	10	domain	domain	NN
cord-269011-230p8rsf	247	11	,	,	,
cord-269011-230p8rsf	247	12	which	which	WDT
cord-269011-230p8rsf	247	13	occurs	occur	VBZ
cord-269011-230p8rsf	247	14	in	in	IN
cord-269011-230p8rsf	247	15	the	the	DT
cord-269011-230p8rsf	247	16	context	context	NN
cord-269011-230p8rsf	247	17	of	of	IN
cord-269011-230p8rsf	247	18	a	a	DT
cord-269011-230p8rsf	247	19	potential	potential	JJ
cord-269011-230p8rsf	247	20	internalization	internalization	NN
cord-269011-230p8rsf	247	21	signal	signal	NN
cord-269011-230p8rsf	247	22	,	,	,
cord-269011-230p8rsf	247	23	resulted	result	VBD
cord-269011-230p8rsf	247	24	in	in	IN
cord-269011-230p8rsf	247	25	plasma	plasma	NN
cord-269011-230p8rsf	247	26	membrane	membrane	NN
cord-269011-230p8rsf	247	27	localization	localization	NN
cord-269011-230p8rsf	247	28	(	(	-LRB-
cord-269011-230p8rsf	247	29	C.	C.	NNP
cord-269011-230p8rsf	247	30	A.	a.	NN
cord-269011-230p8rsf	247	31	M.	M.	NNP
cord-269011-230p8rsf	247	32	de	de	FW
cord-269011-230p8rsf	247	33	Haan	Haan	NNP
cord-269011-230p8rsf	247	34	and	and	CC
cord-269011-230p8rsf	247	35	P.	P.	NNP
cord-269011-230p8rsf	247	36	J.	J.	NNP
cord-269011-230p8rsf	247	37	M.	M.	NNP
cord-269011-230p8rsf	247	38	Rottier	Rottier	NNP
cord-269011-230p8rsf	247	39	,	,	,
cord-269011-230p8rsf	247	40	unpublished	unpublished	JJ
cord-269011-230p8rsf	247	41	results	result	NNS
cord-269011-230p8rsf	247	42	)	)	-RRB-
cord-269011-230p8rsf	247	43	.	.	.
cord-269011-230p8rsf	248	1	The	the	DT
cord-269011-230p8rsf	248	2	first	first	JJ
cord-269011-230p8rsf	248	3	transmembrane	transmembrane	NN
cord-269011-230p8rsf	248	4	domain	domain	NN
cord-269011-230p8rsf	248	5	of	of	IN
cord-269011-230p8rsf	248	6	the	the	DT
cord-269011-230p8rsf	248	7	IBV	IBV	NNP
cord-269011-230p8rsf	248	8	M	M	NNP
cord-269011-230p8rsf	248	9	protein	protein	NN
cord-269011-230p8rsf	248	10	was	be	VBD
cord-269011-230p8rsf	248	11	shown	show	VBN
cord-269011-230p8rsf	248	12	to	to	TO
cord-269011-230p8rsf	248	13	be	be	VB
cord-269011-230p8rsf	248	14	required	require	VBN
cord-269011-230p8rsf	248	15	and	and	CC
cord-269011-230p8rsf	248	16	sufficient	sufficient	JJ
cord-269011-230p8rsf	248	17	for	for	IN
cord-269011-230p8rsf	248	18	localization	localization	NN
cord-269011-230p8rsf	248	19	to	to	IN
cord-269011-230p8rsf	248	20	the	the	DT
cord-269011-230p8rsf	248	21	cis	cis	NNP
cord-269011-230p8rsf	248	22	-	-	HYPH
cord-269011-230p8rsf	248	23	Golgi	Golgi	NNP
cord-269011-230p8rsf	248	24	region	region	NN
cord-269011-230p8rsf	248	25	(	(	-LRB-
cord-269011-230p8rsf	248	26	Machamer	Machamer	NNP
cord-269011-230p8rsf	248	27	and	and	CC
cord-269011-230p8rsf	248	28	Rose	Rose	NNP
cord-269011-230p8rsf	248	29	,	,	,
cord-269011-230p8rsf	248	30	1987	1987	CD
cord-269011-230p8rsf	248	31	;	;	:
cord-269011-230p8rsf	248	32	Machamer	Machamer	NNP
cord-269011-230p8rsf	248	33	et	et	NNP
cord-269011-230p8rsf	248	34	al	al	NNP
cord-269011-230p8rsf	248	35	.	.	.
cord-269011-230p8rsf	249	1	,	,	,
cord-269011-230p8rsf	249	2	1990	1990	CD
cord-269011-230p8rsf	249	3	Machamer	Machamer	NNP
cord-269011-230p8rsf	249	4	et	et	NNP
cord-269011-230p8rsf	249	5	al	al	NNP
cord-269011-230p8rsf	249	6	.	.	.
cord-269011-230p8rsf	250	1	,	,	,
cord-269011-230p8rsf	251	1	,	,	,
cord-269011-230p8rsf	251	2	1993	1993	CD
cord-269011-230p8rsf	251	3	Swift	Swift	NNP
cord-269011-230p8rsf	251	4	and	and	CC
cord-269011-230p8rsf	251	5	Machamer	Machamer	NNP
cord-269011-230p8rsf	251	6	,	,	,
cord-269011-230p8rsf	251	7	1991	1991	CD
cord-269011-230p8rsf	251	8	)	)	-RRB-
cord-269011-230p8rsf	251	9	.	.	.
cord-269011-230p8rsf	252	1	This	this	DT
cord-269011-230p8rsf	252	2	is	be	VBZ
cord-269011-230p8rsf	252	3	not	not	RB
cord-269011-230p8rsf	252	4	the	the	DT
cord-269011-230p8rsf	252	5	case	case	NN
cord-269011-230p8rsf	252	6	for	for	IN
cord-269011-230p8rsf	252	7	the	the	DT
cord-269011-230p8rsf	252	8	MHV	MHV	NNP
cord-269011-230p8rsf	252	9	M	M	NNP
cord-269011-230p8rsf	252	10	protein	protein	NN
cord-269011-230p8rsf	252	11	of	of	IN
cord-269011-230p8rsf	252	12	which	which	WDT
cord-269011-230p8rsf	252	13	mutants	mutant	NNS
cord-269011-230p8rsf	252	14	with	with	IN
cord-269011-230p8rsf	252	15	only	only	RB
cord-269011-230p8rsf	252	16	the	the	DT
cord-269011-230p8rsf	252	17	first	first	JJ
cord-269011-230p8rsf	252	18	transmembrane	transmembrane	NN
cord-269011-230p8rsf	252	19	domain	domain	NN
cord-269011-230p8rsf	252	20	did	do	VBD
cord-269011-230p8rsf	252	21	not	not	RB
cord-269011-230p8rsf	252	22	leave	leave	VB
cord-269011-230p8rsf	252	23	the	the	DT
cord-269011-230p8rsf	252	24	ER	er	NN
cord-269011-230p8rsf	253	1	(	(	-LRB-
cord-269011-230p8rsf	253	2	Armstrong	Armstrong	NNP
cord-269011-230p8rsf	253	3	et	et	NNP
cord-269011-230p8rsf	253	4	al	al	NNP
cord-269011-230p8rsf	253	5	.	.	.
cord-269011-230p8rsf	254	1	,	,	,
cord-269011-230p8rsf	254	2	1990	1990	CD
cord-269011-230p8rsf	254	3	;	;	:
cord-269011-230p8rsf	254	4	Locker	Locker	NNP
cord-269011-230p8rsf	254	5	et	et	NNP
cord-269011-230p8rsf	254	6	al	al	NNP
cord-269011-230p8rsf	254	7	.	.	.
cord-269011-230p8rsf	255	1	,	,	,
cord-269011-230p8rsf	255	2	1994	1994	CD
cord-269011-230p8rsf	255	3	;	;	:
cord-269011-230p8rsf	255	4	Rottier	Rottier	NNP
cord-269011-230p8rsf	255	5	et	et	NNP
cord-269011-230p8rsf	255	6	al	al	NNP
cord-269011-230p8rsf	255	7	.	.	NNP
cord-269011-230p8rsf	255	8	,	,	,
cord-269011-230p8rsf	255	9	1990	1990	CD
cord-269011-230p8rsf	255	10	)	)	-RRB-
cord-269011-230p8rsf	255	11	.	.	.
cord-269011-230p8rsf	256	1	Moreover	moreover	RB
cord-269011-230p8rsf	256	2	,	,	,
cord-269011-230p8rsf	256	3	insertion	insertion	NN
cord-269011-230p8rsf	256	4	of	of	IN
cord-269011-230p8rsf	256	5	the	the	DT
cord-269011-230p8rsf	256	6	first	first	JJ
cord-269011-230p8rsf	256	7	transmembrane	transmembrane	NN
cord-269011-230p8rsf	256	8	domain	domain	NN
cord-269011-230p8rsf	256	9	of	of	IN
cord-269011-230p8rsf	256	10	MHV	MHV	NNP
cord-269011-230p8rsf	256	11	M	M	NNP
cord-269011-230p8rsf	256	12	into	into	IN
cord-269011-230p8rsf	256	13	a	a	DT
cord-269011-230p8rsf	256	14	reporter	reporter	NN
cord-269011-230p8rsf	256	15	protein	protein	NN
cord-269011-230p8rsf	256	16	resulted	result	VBD
cord-269011-230p8rsf	256	17	in	in	IN
cord-269011-230p8rsf	256	18	a	a	DT
cord-269011-230p8rsf	256	19	chimeric	chimeric	JJ
cord-269011-230p8rsf	256	20	protein	protein	NN
cord-269011-230p8rsf	256	21	that	that	WDT
cord-269011-230p8rsf	256	22	was	be	VBD
cord-269011-230p8rsf	256	23	transported	transport	VBN
cord-269011-230p8rsf	256	24	to	to	IN
cord-269011-230p8rsf	256	25	the	the	DT
cord-269011-230p8rsf	256	26	cell	cell	NN
cord-269011-230p8rsf	256	27	surface	surface	NN
cord-269011-230p8rsf	256	28	(	(	-LRB-
cord-269011-230p8rsf	256	29	Armstrong	Armstrong	NNP
cord-269011-230p8rsf	256	30	and	and	CC
cord-269011-230p8rsf	256	31	Patel	Patel	NNP
cord-269011-230p8rsf	256	32	,	,	,
cord-269011-230p8rsf	256	33	1991	1991	CD
cord-269011-230p8rsf	256	34	;	;	:
cord-269011-230p8rsf	256	35	Machamer	Machamer	NNP
cord-269011-230p8rsf	256	36	et	et	NNP
cord-269011-230p8rsf	256	37	al	al	NNP
cord-269011-230p8rsf	256	38	.	.	NNP
cord-269011-230p8rsf	256	39	,	,	,
cord-269011-230p8rsf	256	40	1993	1993	CD
cord-269011-230p8rsf	256	41	)	)	-RRB-
cord-269011-230p8rsf	256	42	,	,	,
cord-269011-230p8rsf	256	43	unlike	unlike	IN
cord-269011-230p8rsf	256	44	a	a	DT
cord-269011-230p8rsf	256	45	similar	similar	JJ
cord-269011-230p8rsf	256	46	chimeric	chimeric	JJ
cord-269011-230p8rsf	256	47	protein	protein	NN
cord-269011-230p8rsf	256	48	containing	contain	VBG
cord-269011-230p8rsf	256	49	the	the	DT
cord-269011-230p8rsf	256	50	first	first	JJ
cord-269011-230p8rsf	256	51	transmembrane	transmembrane	NN
cord-269011-230p8rsf	256	52	domain	domain	NN
cord-269011-230p8rsf	256	53	of	of	IN
cord-269011-230p8rsf	256	54	IBV	IBV	NNP
cord-269011-230p8rsf	256	55	that	that	WDT
cord-269011-230p8rsf	256	56	was	be	VBD
cord-269011-230p8rsf	256	57	retained	retain	VBN
cord-269011-230p8rsf	256	58	in	in	IN
cord-269011-230p8rsf	256	59	the	the	DT
cord-269011-230p8rsf	256	60	Golgi	Golgi	NNP
cord-269011-230p8rsf	256	61	compartment	compartment	NN
cord-269011-230p8rsf	256	62	.	.	.
cord-269011-230p8rsf	257	1	Other	other	JJ
cord-269011-230p8rsf	257	2	MHV	MHV	NNP
cord-269011-230p8rsf	257	3	M	M	NNP
cord-269011-230p8rsf	257	4	mutant	mutant	JJ
cord-269011-230p8rsf	257	5	proteins	protein	NNS
cord-269011-230p8rsf	257	6	lacking	lack	VBG
cord-269011-230p8rsf	257	7	the	the	DT
cord-269011-230p8rsf	257	8	first	first	JJ
cord-269011-230p8rsf	257	9	and	and	CC
cord-269011-230p8rsf	257	10	second	second	JJ
cord-269011-230p8rsf	257	11	transmembrane	transmembrane	NN
cord-269011-230p8rsf	257	12	domains	domain	NNS
cord-269011-230p8rsf	257	13	were	be	VBD
cord-269011-230p8rsf	257	14	also	also	RB
cord-269011-230p8rsf	257	15	not	not	RB
cord-269011-230p8rsf	257	16	efficiently	efficiently	RB
cord-269011-230p8rsf	257	17	retained	retain	VBN
cord-269011-230p8rsf	257	18	in	in	IN
cord-269011-230p8rsf	257	19	the	the	DT
cord-269011-230p8rsf	257	20	Golgi	Golgi	NNP
cord-269011-230p8rsf	257	21	compartment	compartment	NN
cord-269011-230p8rsf	257	22	and	and	CC
cord-269011-230p8rsf	257	23	were	be	VBD
cord-269011-230p8rsf	257	24	diverted	divert	VBN
cord-269011-230p8rsf	257	25	to	to	IN
cord-269011-230p8rsf	257	26	endosomal	endosomal	NNP
cord-269011-230p8rsf	257	27	structures	structure	NNS
cord-269011-230p8rsf	257	28	(	(	-LRB-
cord-269011-230p8rsf	257	29	Armstrong	Armstrong	NNP
cord-269011-230p8rsf	257	30	et	et	NNP
cord-269011-230p8rsf	257	31	al	al	NNP
cord-269011-230p8rsf	257	32	.	.	NNP
cord-269011-230p8rsf	257	33	,	,	,
cord-269011-230p8rsf	257	34	1990	1990	CD
cord-269011-230p8rsf	257	35	;	;	:
cord-269011-230p8rsf	258	1	Locker	Locker	NNP
cord-269011-230p8rsf	258	2	et	et	NNP
cord-269011-230p8rsf	258	3	al	al	NNP
cord-269011-230p8rsf	258	4	.	.	NNP
cord-269011-230p8rsf	258	5	,	,	,
cord-269011-230p8rsf	258	6	1994	1994	CD
cord-269011-230p8rsf	258	7	)	)	-RRB-
cord-269011-230p8rsf	258	8	.	.	.
cord-269011-230p8rsf	259	1	The	the	DT
cord-269011-230p8rsf	259	2	mechanism	mechanism	NN
cord-269011-230p8rsf	259	3	by	by	IN
cord-269011-230p8rsf	259	4	which	which	WDT
cord-269011-230p8rsf	259	5	Golgi	Golgi	NNP
cord-269011-230p8rsf	259	6	retention	retention	NN
cord-269011-230p8rsf	259	7	of	of	IN
cord-269011-230p8rsf	259	8	M	M	NNP
cord-269011-230p8rsf	259	9	proteins	protein	NNS
cord-269011-230p8rsf	259	10	is	be	VBZ
cord-269011-230p8rsf	259	11	regulated	regulate	VBN
cord-269011-230p8rsf	259	12	has	have	VBZ
cord-269011-230p8rsf	259	13	not	not	RB
cord-269011-230p8rsf	259	14	yet	yet	RB
cord-269011-230p8rsf	259	15	been	be	VBN
cord-269011-230p8rsf	259	16	resolved	resolve	VBN
cord-269011-230p8rsf	259	17	.	.	.
cord-269011-230p8rsf	260	1	However	however	RB
cord-269011-230p8rsf	260	2	,	,	,
cord-269011-230p8rsf	260	3	oligomerization	oligomerization	NN
cord-269011-230p8rsf	260	4	of	of	IN
cord-269011-230p8rsf	260	5	the	the	DT
cord-269011-230p8rsf	260	6	proteins	protein	NNS
cord-269011-230p8rsf	260	7	,	,	,
cord-269011-230p8rsf	260	8	mediated	mediate	VBN
cord-269011-230p8rsf	260	9	by	by	IN
cord-269011-230p8rsf	260	10	the	the	DT
cord-269011-230p8rsf	260	11	transmembrane	transmembrane	NN
cord-269011-230p8rsf	260	12	domains	domain	NNS
cord-269011-230p8rsf	260	13	,	,	,
cord-269011-230p8rsf	260	14	seems	seem	VBZ
cord-269011-230p8rsf	260	15	to	to	TO
cord-269011-230p8rsf	260	16	play	play	VB
cord-269011-230p8rsf	260	17	an	an	DT
cord-269011-230p8rsf	260	18	important	important	JJ
cord-269011-230p8rsf	260	19	role	role	NN
cord-269011-230p8rsf	260	20	,	,	,
cord-269011-230p8rsf	260	21	perhaps	perhaps	RB
cord-269011-230p8rsf	260	22	in	in	IN
cord-269011-230p8rsf	260	23	combination	combination	NN
cord-269011-230p8rsf	260	24	with	with	IN
cord-269011-230p8rsf	260	25	retrieval	retrieval	NN
cord-269011-230p8rsf	260	26	mechanisms	mechanism	NNS
cord-269011-230p8rsf	260	27	Maceyka	Maceyka	NNP
cord-269011-230p8rsf	260	28	and	and	CC
cord-269011-230p8rsf	260	29	Machamer	Machamer	NNP
cord-269011-230p8rsf	260	30	,	,	,
cord-269011-230p8rsf	260	31	1997	1997	CD
cord-269011-230p8rsf	260	32	)	)	-RRB-
cord-269011-230p8rsf	260	33	.	.	.
cord-269011-230p8rsf	261	1	Formation	formation	NN
cord-269011-230p8rsf	261	2	of	of	IN
cord-269011-230p8rsf	261	3	oligomeric	oligomeric	JJ
cord-269011-230p8rsf	261	4	complexes	complex	NNS
cord-269011-230p8rsf	261	5	has	have	VBZ
cord-269011-230p8rsf	261	6	been	be	VBN
cord-269011-230p8rsf	261	7	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	261	8	to	to	TO
cord-269011-230p8rsf	261	9	correlate	correlate	VB
cord-269011-230p8rsf	261	10	with	with	IN
cord-269011-230p8rsf	261	11	Golgi	Golgi	NNP
cord-269011-230p8rsf	261	12	retention	retention	NN
cord-269011-230p8rsf	261	13	of	of	IN
cord-269011-230p8rsf	261	14	a	a	DT
cord-269011-230p8rsf	261	15	reporter	reporter	NN
cord-269011-230p8rsf	261	16	protein	protein	NN
cord-269011-230p8rsf	261	17	containing	contain	VBG
cord-269011-230p8rsf	261	18	the	the	DT
cord-269011-230p8rsf	261	19	first	first	JJ
cord-269011-230p8rsf	261	20	transmembrane	transmembrane	NN
cord-269011-230p8rsf	261	21	domain	domain	NN
cord-269011-230p8rsf	261	22	of	of	IN
cord-269011-230p8rsf	261	23	IBV	IBV	NNP
cord-269011-230p8rsf	261	24	M	M	NNP
cord-269011-230p8rsf	261	25	(	(	-LRB-
cord-269011-230p8rsf	261	26	Weisz	Weisz	NNP
cord-269011-230p8rsf	261	27	et	et	NNP
cord-269011-230p8rsf	261	28	al	al	NNP
cord-269011-230p8rsf	261	29	.	.	NNP
cord-269011-230p8rsf	261	30	,	,	,
cord-269011-230p8rsf	261	31	1993	1993	CD
cord-269011-230p8rsf	261	32	)	)	-RRB-
cord-269011-230p8rsf	261	33	while	while	IN
cord-269011-230p8rsf	261	34	also	also	RB
cord-269011-230p8rsf	261	35	the	the	DT
cord-269011-230p8rsf	261	36	Golgi	Golgi	NNP
cord-269011-230p8rsf	261	37	-	-	HYPH
cord-269011-230p8rsf	261	38	resident	resident	NN
cord-269011-230p8rsf	261	39	MHV	MHV	NNP
cord-269011-230p8rsf	261	40	M	M	NNP
cord-269011-230p8rsf	261	41	protein	protein	NN
cord-269011-230p8rsf	261	42	was	be	VBD
cord-269011-230p8rsf	261	43	found	find	VBN
cord-269011-230p8rsf	261	44	to	to	TO
cord-269011-230p8rsf	261	45	occur	occur	VB
cord-269011-230p8rsf	261	46	in	in	IN
cord-269011-230p8rsf	261	47	large	large	JJ
cord-269011-230p8rsf	261	48	,	,	,
cord-269011-230p8rsf	261	49	homomeric	homomeric	NNP
cord-269011-230p8rsf	261	50	complexes	complex	NNS
cord-269011-230p8rsf	261	51	(	(	-LRB-
cord-269011-230p8rsf	261	52	Locker	Locker	NNP
cord-269011-230p8rsf	261	53	et	et	FW
cord-269011-230p8rsf	261	54	al	al	NNP
cord-269011-230p8rsf	261	55	.	.	NNP
cord-269011-230p8rsf	261	56	,	,	,
cord-269011-230p8rsf	261	57	1995	1995	CD
cord-269011-230p8rsf	261	58	)	)	-RRB-
cord-269011-230p8rsf	261	59	.	.	.
cord-269011-230p8rsf	262	1	The	the	DT
cord-269011-230p8rsf	262	2	lumenal	lumenal	JJ
cord-269011-230p8rsf	262	3	domain	domain	NN
cord-269011-230p8rsf	262	4	of	of	IN
cord-269011-230p8rsf	262	5	the	the	DT
cord-269011-230p8rsf	262	6	M	M	NNP
cord-269011-230p8rsf	262	7	protein	protein	NN
cord-269011-230p8rsf	262	8	does	do	VBZ
cord-269011-230p8rsf	262	9	not	not	RB
cord-269011-230p8rsf	262	10	appear	appear	VB
cord-269011-230p8rsf	262	11	to	to	TO
cord-269011-230p8rsf	262	12	contribute	contribute	VB
cord-269011-230p8rsf	262	13	to	to	IN
cord-269011-230p8rsf	262	14	localization	localization	NN
cord-269011-230p8rsf	262	15	;	;	:
cord-269011-230p8rsf	262	16	its	-PRON-	PRP$
cord-269011-230p8rsf	262	17	deletion	deletion	NN
cord-269011-230p8rsf	262	18	from	from	IN
cord-269011-230p8rsf	262	19	MHV	MHV	NNP
cord-269011-230p8rsf	262	20	M	M	NNP
cord-269011-230p8rsf	262	21	did	do	VBD
cord-269011-230p8rsf	262	22	not	not	RB
cord-269011-230p8rsf	262	23	affect	affect	VB
cord-269011-230p8rsf	262	24	the	the	DT
cord-269011-230p8rsf	262	25	intracellular	intracellular	JJ
cord-269011-230p8rsf	262	26	destination	destination	NN
cord-269011-230p8rsf	262	27	of	of	IN
cord-269011-230p8rsf	262	28	the	the	DT
cord-269011-230p8rsf	262	29	protein	protein	NN
cord-269011-230p8rsf	263	1	(	(	-LRB-
cord-269011-230p8rsf	263	2	Mayer	Mayer	NNP
cord-269011-230p8rsf	263	3	et	et	NNP
cord-269011-230p8rsf	263	4	al	al	NNP
cord-269011-230p8rsf	263	5	.	.	.
cord-269011-230p8rsf	264	1	,	,	,
cord-269011-230p8rsf	264	2	1988	1988	CD
cord-269011-230p8rsf	264	3	;	;	:
cord-269011-230p8rsf	264	4	Rottier	Rottier	NNP
cord-269011-230p8rsf	264	5	et	et	NNP
cord-269011-230p8rsf	264	6	al	al	NNP
cord-269011-230p8rsf	264	7	.	.	NNP
cord-269011-230p8rsf	264	8	,	,	,
cord-269011-230p8rsf	264	9	1990	1990	CD
cord-269011-230p8rsf	264	10	)	)	-RRB-
cord-269011-230p8rsf	264	11	.	.	.
cord-269011-230p8rsf	265	1	In	in	IN
cord-269011-230p8rsf	265	2	infected	infected	JJ
cord-269011-230p8rsf	265	3	cells	cell	NNS
cord-269011-230p8rsf	265	4	the	the	DT
cord-269011-230p8rsf	265	5	M	M	NNP
cord-269011-230p8rsf	265	6	proteins	protein	NNS
cord-269011-230p8rsf	265	7	of	of	IN
cord-269011-230p8rsf	265	8	IBV	IBV	NNP
cord-269011-230p8rsf	265	9	and	and	CC
cord-269011-230p8rsf	265	10	MHV	MHV	NNP
cord-269011-230p8rsf	265	11	were	be	VBD
cord-269011-230p8rsf	265	12	observed	observe	VBN
cord-269011-230p8rsf	265	13	to	to	TO
cord-269011-230p8rsf	265	14	occur	occur	VB
cord-269011-230p8rsf	265	15	in	in	IN
cord-269011-230p8rsf	265	16	the	the	DT
cord-269011-230p8rsf	265	17	membranes	membrane	NNS
cord-269011-230p8rsf	265	18	of	of	IN
cord-269011-230p8rsf	265	19	the	the	DT
cord-269011-230p8rsf	265	20	budding	bud	VBG
cord-269011-230p8rsf	265	21	compartment	compartment	NN
cord-269011-230p8rsf	265	22	as	as	RB
cord-269011-230p8rsf	265	23	well	well	RB
cord-269011-230p8rsf	265	24	as	as	IN
cord-269011-230p8rsf	265	25	in	in	IN
cord-269011-230p8rsf	265	26	the	the	DT
cord-269011-230p8rsf	265	27	Golgi	Golgi	NNP
cord-269011-230p8rsf	265	28	compartment	compartment	NN
cord-269011-230p8rsf	265	29	.	.	.
cord-269011-230p8rsf	266	1	Under	under	IN
cord-269011-230p8rsf	266	2	these	these	DT
cord-269011-230p8rsf	266	3	conditions	condition	NNS
cord-269011-230p8rsf	266	4	their	-PRON-	PRP$
cord-269011-230p8rsf	266	5	cis	cis	JJ
cord-269011-230p8rsf	266	6	-	-	HYPH
cord-269011-230p8rsf	266	7	trans	trans	NNP
cord-269011-230p8rsf	266	8	distribution	distribution	NN
cord-269011-230p8rsf	266	9	in	in	IN
cord-269011-230p8rsf	266	10	the	the	DT
cord-269011-230p8rsf	266	11	Golgi	Golgi	NNP
cord-269011-230p8rsf	266	12	compartment	compartment	NN
cord-269011-230p8rsf	266	13	was	be	VBD
cord-269011-230p8rsf	266	14	the	the	DT
cord-269011-230p8rsf	266	15	same	same	JJ
cord-269011-230p8rsf	266	16	as	as	IN
cord-269011-230p8rsf	266	17	when	when	WRB
cord-269011-230p8rsf	266	18	these	these	DT
cord-269011-230p8rsf	266	19	proteins	protein	NNS
cord-269011-230p8rsf	266	20	were	be	VBD
cord-269011-230p8rsf	266	21	expressed	express	VBN
cord-269011-230p8rsf	266	22	independently	independently	RB
cord-269011-230p8rsf	267	1	Machamer	Machamer	NNP
cord-269011-230p8rsf	267	2	et	et	NNP
cord-269011-230p8rsf	267	3	al	al	NNP
cord-269011-230p8rsf	267	4	.	.	NNP
cord-269011-230p8rsf	267	5	,	,	,
cord-269011-230p8rsf	267	6	1990	1990	CD
cord-269011-230p8rsf	267	7	)	)	-RRB-
cord-269011-230p8rsf	267	8	.	.	.
cord-269011-230p8rsf	268	1	The	the	DT
cord-269011-230p8rsf	268	2	E	e	NN
cord-269011-230p8rsf	268	3	protein	protein	NN
cord-269011-230p8rsf	268	4	(	(	-LRB-
cord-269011-230p8rsf	268	5	previously	previously	RB
cord-269011-230p8rsf	268	6	known	know	VBN
cord-269011-230p8rsf	268	7	as	as	IN
cord-269011-230p8rsf	268	8	sM	sm	NN
cord-269011-230p8rsf	268	9	protein	protein	NN
cord-269011-230p8rsf	268	10	)	)	-RRB-
cord-269011-230p8rsf	268	11	is	be	VBZ
cord-269011-230p8rsf	268	12	a	a	DT
cord-269011-230p8rsf	268	13	small	small	JJ
cord-269011-230p8rsf	268	14	protein	protein	NN
cord-269011-230p8rsf	268	15	(	(	-LRB-
cord-269011-230p8rsf	268	16	76	76	CD
cord-269011-230p8rsf	268	17	-	-	SYM
cord-269011-230p8rsf	268	18	109	109	CD
cord-269011-230p8rsf	268	19	residues	residue	NNS
cord-269011-230p8rsf	268	20	)	)	-RRB-
cord-269011-230p8rsf	268	21	and	and	CC
cord-269011-230p8rsf	268	22	a	a	DT
cord-269011-230p8rsf	268	23	minor	minor	JJ
cord-269011-230p8rsf	268	24	component	component	NN
cord-269011-230p8rsf	268	25	of	of	IN
cord-269011-230p8rsf	268	26	the	the	DT
cord-269011-230p8rsf	268	27	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	268	28	envelope	envelope	NN
cord-269011-230p8rsf	268	29	.	.	.
cord-269011-230p8rsf	269	1	Although	although	IN
cord-269011-230p8rsf	269	2	the	the	DT
cord-269011-230p8rsf	269	3	primary	primary	JJ
cord-269011-230p8rsf	269	4	structures	structure	NNS
cord-269011-230p8rsf	269	5	of	of	IN
cord-269011-230p8rsf	269	6	E	e	NN
cord-269011-230p8rsf	269	7	proteins	protein	NNS
cord-269011-230p8rsf	269	8	are	be	VBP
cord-269011-230p8rsf	269	9	quite	quite	RB
cord-269011-230p8rsf	269	10	conserved	conserve	VBN
cord-269011-230p8rsf	269	11	within	within	IN
cord-269011-230p8rsf	269	12	the	the	DT
cord-269011-230p8rsf	269	13	different	different	JJ
cord-269011-230p8rsf	269	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	269	15	groups	group	NNS
cord-269011-230p8rsf	269	16	,	,	,
cord-269011-230p8rsf	269	17	they	-PRON-	PRP
cord-269011-230p8rsf	269	18	share	share	VBP
cord-269011-230p8rsf	269	19	little	little	JJ
cord-269011-230p8rsf	269	20	homology	homology	NN
cord-269011-230p8rsf	269	21	between	between	IN
cord-269011-230p8rsf	269	22	the	the	DT
cord-269011-230p8rsf	269	23	groups	group	NNS
cord-269011-230p8rsf	269	24	.	.	.
cord-269011-230p8rsf	270	1	However	however	RB
cord-269011-230p8rsf	270	2	,	,	,
cord-269011-230p8rsf	270	3	the	the	DT
cord-269011-230p8rsf	270	4	proteins	protein	NNS
cord-269011-230p8rsf	270	5	have	have	VBP
cord-269011-230p8rsf	270	6	several	several	JJ
cord-269011-230p8rsf	270	7	structural	structural	JJ
cord-269011-230p8rsf	270	8	features	feature	NNS
cord-269011-230p8rsf	270	9	in	in	IN
cord-269011-230p8rsf	270	10	common	common	JJ
cord-269011-230p8rsf	270	11	.	.	.
cord-269011-230p8rsf	271	1	The	the	DT
cord-269011-230p8rsf	271	2	E	e	NN
cord-269011-230p8rsf	271	3	protein	protein	NN
cord-269011-230p8rsf	271	4	contains	contain	VBZ
cord-269011-230p8rsf	271	5	a	a	DT
cord-269011-230p8rsf	271	6	relatively	relatively	RB
cord-269011-230p8rsf	271	7	large	large	JJ
cord-269011-230p8rsf	271	8	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	271	9	region	region	NN
cord-269011-230p8rsf	271	10	in	in	IN
cord-269011-230p8rsf	271	11	its	-PRON-	PRP$
cord-269011-230p8rsf	271	12	amino	amino	NN
cord-269011-230p8rsf	271	13	-	-	HYPH
cord-269011-230p8rsf	271	14	terminal	terminal	NN
cord-269011-230p8rsf	271	15	half	half	NN
cord-269011-230p8rsf	271	16	,	,	,
cord-269011-230p8rsf	271	17	followed	follow	VBN
cord-269011-230p8rsf	271	18	by	by	IN
cord-269011-230p8rsf	271	19	a	a	DT
cord-269011-230p8rsf	271	20	cysteine	cysteine	NN
cord-269011-230p8rsf	271	21	-	-	HYPH
cord-269011-230p8rsf	271	22	rich	rich	JJ
cord-269011-230p8rsf	271	23	region	region	NN
cord-269011-230p8rsf	271	24	,	,	,
cord-269011-230p8rsf	271	25	an	an	DT
cord-269011-230p8rsf	271	26	absolutely	absolutely	RB
cord-269011-230p8rsf	271	27	conserved	conserve	VBN
cord-269011-230p8rsf	271	28	proline	proline	NN
cord-269011-230p8rsf	271	29	residue	residue	NN
cord-269011-230p8rsf	271	30	,	,	,
cord-269011-230p8rsf	271	31	and	and	CC
cord-269011-230p8rsf	271	32	a	a	DT
cord-269011-230p8rsf	271	33	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	271	34	tail	tail	NN
cord-269011-230p8rsf	271	35	.	.	.
cord-269011-230p8rsf	272	1	E	E	NNP
cord-269011-230p8rsf	272	2	is	be	VBZ
cord-269011-230p8rsf	272	3	an	an	DT
cord-269011-230p8rsf	272	4	integral	integral	JJ
cord-269011-230p8rsf	272	5	membrane	membrane	NN
cord-269011-230p8rsf	272	6	protein	protein	NN
cord-269011-230p8rsf	272	7	,	,	,
cord-269011-230p8rsf	272	8	which	which	WDT
cord-269011-230p8rsf	272	9	is	be	VBZ
cord-269011-230p8rsf	272	10	assembled	assemble	VBN
cord-269011-230p8rsf	272	11	in	in	IN
cord-269011-230p8rsf	272	12	membranes	membrane	NNS
cord-269011-230p8rsf	272	13	without	without	IN
cord-269011-230p8rsf	272	14	the	the	DT
cord-269011-230p8rsf	272	15	involvement	involvement	NN
cord-269011-230p8rsf	272	16	of	of	IN
cord-269011-230p8rsf	272	17	a	a	DT
cord-269011-230p8rsf	272	18	cleaved	cleave	VBN
cord-269011-230p8rsf	272	19	signal	signal	NN
cord-269011-230p8rsf	272	20	peptide	peptide	NN
cord-269011-230p8rsf	272	21	.	.	.
cord-269011-230p8rsf	273	1	Its	-PRON-	PRP$
cord-269011-230p8rsf	273	2	membrane	membrane	NN
cord-269011-230p8rsf	273	3	topology	topology	NN
cord-269011-230p8rsf	273	4	has	have	VBZ
cord-269011-230p8rsf	273	5	not	not	RB
cord-269011-230p8rsf	273	6	been	be	VBN
cord-269011-230p8rsf	273	7	firmly	firmly	RB
cord-269011-230p8rsf	273	8	established	establish	VBN
cord-269011-230p8rsf	273	9	.	.	.
cord-269011-230p8rsf	274	1	Although	although	IN
cord-269011-230p8rsf	274	2	the	the	DT
cord-269011-230p8rsf	274	3	opposite	opposite	NN
cord-269011-230p8rsf	274	4	was	be	VBD
cord-269011-230p8rsf	274	5	proposed	propose	VBN
cord-269011-230p8rsf	274	6	initially	initially	RB
cord-269011-230p8rsf	274	7	for	for	IN
cord-269011-230p8rsf	274	8	the	the	DT
cord-269011-230p8rsf	274	9	TGEV	TGEV	NNP
cord-269011-230p8rsf	274	10	E	e	NN
cord-269011-230p8rsf	274	11	protein	protein	NN
cord-269011-230p8rsf	274	12	(	(	-LRB-
cord-269011-230p8rsf	274	13	Godet	Godet	NNP
cord-269011-230p8rsf	274	14	et	et	NNP
cord-269011-230p8rsf	274	15	al	al	NNP
cord-269011-230p8rsf	274	16	.	.	NNP
cord-269011-230p8rsf	274	17	,	,	,
cord-269011-230p8rsf	274	18	1992	1992	CD
cord-269011-230p8rsf	274	19	)	)	-RRB-
cord-269011-230p8rsf	274	20	,	,	,
cord-269011-230p8rsf	274	21	there	there	EX
cord-269011-230p8rsf	274	22	seems	seem	VBZ
cord-269011-230p8rsf	274	23	to	to	TO
cord-269011-230p8rsf	274	24	be	be	VB
cord-269011-230p8rsf	274	25	consensus	consensus	NN
cord-269011-230p8rsf	274	26	about	about	IN
cord-269011-230p8rsf	274	27	the	the	DT
cord-269011-230p8rsf	274	28	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	274	29	carboxy	carboxy	JJ
cord-269011-230p8rsf	274	30	terminus	terminus	NN
cord-269011-230p8rsf	274	31	being	be	VBG
cord-269011-230p8rsf	274	32	exposed	expose	VBN
cord-269011-230p8rsf	274	33	on	on	IN
cord-269011-230p8rsf	274	34	the	the	DT
cord-269011-230p8rsf	274	35	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	274	36	side	side	NN
cord-269011-230p8rsf	274	37	in	in	IN
cord-269011-230p8rsf	274	38	cells	cell	NNS
cord-269011-230p8rsf	274	39	or	or	CC
cord-269011-230p8rsf	274	40	on	on	IN
cord-269011-230p8rsf	274	41	the	the	DT
cord-269011-230p8rsf	274	42	inside	inside	NN
cord-269011-230p8rsf	274	43	of	of	IN
cord-269011-230p8rsf	274	44	the	the	DT
cord-269011-230p8rsf	274	45	virion	virion	NN
cord-269011-230p8rsf	274	46	(	(	-LRB-
cord-269011-230p8rsf	274	47	Corse	Corse	NNP
cord-269011-230p8rsf	274	48	and	and	CC
cord-269011-230p8rsf	274	49	Machamer	Machamer	NNP
cord-269011-230p8rsf	274	50	,	,	,
cord-269011-230p8rsf	274	51	2000	2000	CD
cord-269011-230p8rsf	274	52	;	;	:
cord-269011-230p8rsf	274	53	Raamsman	Raamsman	NNP
cord-269011-230p8rsf	274	54	et	et	NNP
cord-269011-230p8rsf	274	55	al	al	NNP
cord-269011-230p8rsf	274	56	.	.	NNP
cord-269011-230p8rsf	274	57	,	,	,
cord-269011-230p8rsf	274	58	2000	2000	CD
cord-269011-230p8rsf	274	59	)	)	-RRB-
cord-269011-230p8rsf	274	60	.	.	.
cord-269011-230p8rsf	275	1	The	the	DT
cord-269011-230p8rsf	275	2	amino	amino	NN
cord-269011-230p8rsf	275	3	terminus	terminus	NN
cord-269011-230p8rsf	275	4	of	of	IN
cord-269011-230p8rsf	275	5	the	the	DT
cord-269011-230p8rsf	275	6	MHV	MHV	NNP
cord-269011-230p8rsf	275	7	E	E	NNP
cord-269011-230p8rsf	275	8	protein	protein	NN
cord-269011-230p8rsf	275	9	was	be	VBD
cord-269011-230p8rsf	275	10	not	not	RB
cord-269011-230p8rsf	275	11	detectably	detectably	RB
cord-269011-230p8rsf	275	12	present	present	JJ
cord-269011-230p8rsf	275	13	on	on	IN
cord-269011-230p8rsf	275	14	the	the	DT
cord-269011-230p8rsf	275	15	virion	virion	NN
cord-269011-230p8rsf	275	16	outside	outside	RB
cord-269011-230p8rsf	275	17	but	but	CC
cord-269011-230p8rsf	275	18	appeared	appear	VBD
cord-269011-230p8rsf	275	19	to	to	TO
cord-269011-230p8rsf	275	20	be	be	VB
cord-269011-230p8rsf	275	21	exposed	expose	VBN
cord-269011-230p8rsf	275	22	cytoplasmically	cytoplasmically	RB
cord-269011-230p8rsf	275	23	when	when	WRB
cord-269011-230p8rsf	275	24	it	-PRON-	PRP
cord-269011-230p8rsf	275	25	was	be	VBD
cord-269011-230p8rsf	275	26	extended	extend	VBN
cord-269011-230p8rsf	275	27	with	with	IN
cord-269011-230p8rsf	275	28	an	an	DT
cord-269011-230p8rsf	275	29	amino	amino	NN
cord-269011-230p8rsf	275	30	-	-	HYPH
cord-269011-230p8rsf	275	31	terminal	terminal	NN
cord-269011-230p8rsf	275	32	epitope	epitope	NN
cord-269011-230p8rsf	275	33	tag	tag	NN
cord-269011-230p8rsf	275	34	(	(	-LRB-
cord-269011-230p8rsf	275	35	Maeda	Maeda	NNP
cord-269011-230p8rsf	275	36	et	et	NNP
cord-269011-230p8rsf	275	37	al	al	NNP
cord-269011-230p8rsf	275	38	.	.	NNP
cord-269011-230p8rsf	275	39	,	,	,
cord-269011-230p8rsf	275	40	2001	2001	CD
cord-269011-230p8rsf	275	41	)	)	-RRB-
cord-269011-230p8rsf	275	42	,	,	,
cord-269011-230p8rsf	275	43	consistent	consistent	JJ
cord-269011-230p8rsf	275	44	with	with	IN
cord-269011-230p8rsf	275	45	a	a	DT
cord-269011-230p8rsf	275	46	topological	topological	JJ
cord-269011-230p8rsf	275	47	model	model	NN
cord-269011-230p8rsf	275	48	in	in	IN
cord-269011-230p8rsf	275	49	which	which	WDT
cord-269011-230p8rsf	275	50	the	the	DT
cord-269011-230p8rsf	275	51	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	275	52	domain	domain	NN
cord-269011-230p8rsf	275	53	spans	span	VBZ
cord-269011-230p8rsf	275	54	the	the	DT
cord-269011-230p8rsf	275	55	bilayer	bilayer	NN
cord-269011-230p8rsf	275	56	twice	twice	RB
cord-269011-230p8rsf	275	57	.	.	.
cord-269011-230p8rsf	276	1	For	for	IN
cord-269011-230p8rsf	276	2	the	the	DT
cord-269011-230p8rsf	276	3	IBV	IBV	NNP
cord-269011-230p8rsf	276	4	E	E	NNP
cord-269011-230p8rsf	276	5	protein	protein	NN
cord-269011-230p8rsf	276	6	evidence	evidence	NN
cord-269011-230p8rsf	276	7	was	be	VBD
cord-269011-230p8rsf	276	8	provided	provide	VBN
cord-269011-230p8rsf	276	9	indicating	indicate	VBG
cord-269011-230p8rsf	276	10	that	that	IN
cord-269011-230p8rsf	276	11	the	the	DT
cord-269011-230p8rsf	276	12	amino	amino	NN
cord-269011-230p8rsf	276	13	terminus	terminus	NN
cord-269011-230p8rsf	276	14	is	be	VBZ
cord-269011-230p8rsf	276	15	exposed	expose	VBN
cord-269011-230p8rsf	276	16	lumenally	lumenally	RB
cord-269011-230p8rsf	276	17	in	in	IN
cord-269011-230p8rsf	276	18	cells	cell	NNS
cord-269011-230p8rsf	276	19	,	,	,
cord-269011-230p8rsf	276	20	consistent	consistent	JJ
cord-269011-230p8rsf	276	21	with	with	IN
cord-269011-230p8rsf	276	22	a	a	DT
cord-269011-230p8rsf	276	23	single	single	JJ
cord-269011-230p8rsf	276	24	spanning	spanning	NN
cord-269011-230p8rsf	276	25	topology	topology	NN
cord-269011-230p8rsf	276	26	(	(	-LRB-
cord-269011-230p8rsf	276	27	Corse	Corse	NNP
cord-269011-230p8rsf	276	28	and	and	CC
cord-269011-230p8rsf	276	29	Machamer	Machamer	NNP
cord-269011-230p8rsf	276	30	,	,	,
cord-269011-230p8rsf	276	31	2000	2000	CD
cord-269011-230p8rsf	276	32	)	)	-RRB-
cord-269011-230p8rsf	277	1	(	(	-LRB-
cord-269011-230p8rsf	277	2	Fig	Fig	NNP
cord-269011-230p8rsf	277	3	.	.	NNP
cord-269011-230p8rsf	277	4	4	4	CD
cord-269011-230p8rsf	277	5	)	)	-RRB-
cord-269011-230p8rsf	277	6	.	.	.
cord-269011-230p8rsf	278	1	The	the	DT
cord-269011-230p8rsf	278	2	E	e	NN
cord-269011-230p8rsf	278	3	protein	protein	NN
cord-269011-230p8rsf	278	4	is	be	VBZ
cord-269011-230p8rsf	278	5	not	not	RB
cord-269011-230p8rsf	278	6	glycosylated	glycosylate	VBN
cord-269011-230p8rsf	278	7	but	but	CC
cord-269011-230p8rsf	278	8	appears	appear	VBZ
cord-269011-230p8rsf	278	9	to	to	TO
cord-269011-230p8rsf	278	10	become	become	VB
cord-269011-230p8rsf	278	11	palmitoylated	palmitoylated	JJ
cord-269011-230p8rsf	278	12	.	.	.
cord-269011-230p8rsf	279	1	This	this	DT
cord-269011-230p8rsf	279	2	was	be	VBD
cord-269011-230p8rsf	279	3	shown	show	VBN
cord-269011-230p8rsf	279	4	most	most	RBS
cord-269011-230p8rsf	279	5	convincingly	convincingly	RB
cord-269011-230p8rsf	279	6	for	for	IN
cord-269011-230p8rsf	279	7	the	the	DT
cord-269011-230p8rsf	279	8	IBV	IBV	NNP
cord-269011-230p8rsf	279	9	E	e	NN
cord-269011-230p8rsf	279	10	protein	protein	NN
cord-269011-230p8rsf	279	11	by	by	IN
cord-269011-230p8rsf	279	12	labeling	label	VBG
cord-269011-230p8rsf	279	13	with	with	IN
cord-269011-230p8rsf	279	14	[	[	-LRB-
cord-269011-230p8rsf	279	15	3	3	CD
cord-269011-230p8rsf	279	16	H]palmitate	H]palmitate	NNP
cord-269011-230p8rsf	279	17	(	(	-LRB-
cord-269011-230p8rsf	279	18	Corse	Corse	NNP
cord-269011-230p8rsf	279	19	and	and	CC
cord-269011-230p8rsf	279	20	Machamer	Machamer	NNP
cord-269011-230p8rsf	279	21	,	,	,
cord-269011-230p8rsf	279	22	2002	2002	CD
cord-269011-230p8rsf	279	23	)	)	-RRB-
cord-269011-230p8rsf	279	24	,	,	.
cord-269011-230p8rsf	280	1	both	both	DT
cord-269011-230p8rsf	280	2	in	in	IN
cord-269011-230p8rsf	280	3	IBV	IBV	NNP
cord-269011-230p8rsf	280	4	-	-	HYPH
cord-269011-230p8rsf	280	5	infected	infect	VBN
cord-269011-230p8rsf	280	6	cells	cell	NNS
cord-269011-230p8rsf	280	7	and	and	CC
cord-269011-230p8rsf	280	8	when	when	WRB
cord-269011-230p8rsf	280	9	the	the	DT
cord-269011-230p8rsf	280	10	protein	protein	NN
cord-269011-230p8rsf	280	11	was	be	VBD
cord-269011-230p8rsf	280	12	expressed	express	VBN
cord-269011-230p8rsf	280	13	.	.	.
cord-269011-230p8rsf	281	1	Mutagenesis	Mutagenesis	NNP
cord-269011-230p8rsf	281	2	revealed	reveal	VBD
cord-269011-230p8rsf	281	3	that	that	IN
cord-269011-230p8rsf	281	4	one	one	CD
cord-269011-230p8rsf	281	5	or	or	CC
cord-269011-230p8rsf	281	6	both	both	DT
cord-269011-230p8rsf	281	7	of	of	IN
cord-269011-230p8rsf	281	8	the	the	DT
cord-269011-230p8rsf	281	9	two	two	CD
cord-269011-230p8rsf	281	10	conserved	conserved	JJ
cord-269011-230p8rsf	281	11	cysteines	cysteine	NNS
cord-269011-230p8rsf	281	12	became	become	VBD
cord-269011-230p8rsf	281	13	modified	modify	VBN
cord-269011-230p8rsf	281	14	.	.	.
cord-269011-230p8rsf	282	1	The	the	DT
cord-269011-230p8rsf	282	2	result	result	NN
cord-269011-230p8rsf	282	3	is	be	VBZ
cord-269011-230p8rsf	282	4	consistent	consistent	JJ
cord-269011-230p8rsf	282	5	with	with	IN
cord-269011-230p8rsf	282	6	the	the	DT
cord-269011-230p8rsf	282	7	observed	observed	JJ
cord-269011-230p8rsf	282	8	increase	increase	NN
cord-269011-230p8rsf	282	9	in	in	IN
cord-269011-230p8rsf	282	10	electrophoretic	electrophoretic	JJ
cord-269011-230p8rsf	282	11	mobility	mobility	NN
cord-269011-230p8rsf	282	12	of	of	IN
cord-269011-230p8rsf	282	13	the	the	DT
cord-269011-230p8rsf	282	14	MHV	MHV	NNP
cord-269011-230p8rsf	282	15	E	e	NN
cord-269011-230p8rsf	282	16	protein	protein	NN
cord-269011-230p8rsf	282	17	after	after	IN
cord-269011-230p8rsf	282	18	treatment	treatment	NN
cord-269011-230p8rsf	282	19	with	with	IN
cord-269011-230p8rsf	282	20	hydroxylamine	hydroxylamine	CD
cord-269011-230p8rsf	282	21	,	,	,
cord-269011-230p8rsf	282	22	an	an	DT
cord-269011-230p8rsf	282	23	agent	agent	NN
cord-269011-230p8rsf	282	24	that	that	WDT
cord-269011-230p8rsf	282	25	cleaves	cleave	VBZ
cord-269011-230p8rsf	282	26	thioester	thioester	NN
cord-269011-230p8rsf	282	27	-	-	HYPH
cord-269011-230p8rsf	282	28	linked	link	VBN
cord-269011-230p8rsf	282	29	acyl	acyl	NN
cord-269011-230p8rsf	282	30	chains	chain	NNS
cord-269011-230p8rsf	282	31	(	(	-LRB-
cord-269011-230p8rsf	282	32	Yu	Yu	NNP
cord-269011-230p8rsf	282	33	et	et	FW
cord-269011-230p8rsf	282	34	al	al	NNP
cord-269011-230p8rsf	282	35	.	.	NNP
cord-269011-230p8rsf	282	36	,	,	,
cord-269011-230p8rsf	282	37	1994	1994	CD
cord-269011-230p8rsf	282	38	)	)	-RRB-
cord-269011-230p8rsf	282	39	.	.	.
cord-269011-230p8rsf	283	1	Others	other	NNS
cord-269011-230p8rsf	283	2	,	,	,
cord-269011-230p8rsf	283	3	however	however	RB
cord-269011-230p8rsf	283	4	,	,	,
cord-269011-230p8rsf	283	5	were	be	VBD
cord-269011-230p8rsf	283	6	not	not	RB
cord-269011-230p8rsf	283	7	able	able	JJ
cord-269011-230p8rsf	283	8	to	to	TO
cord-269011-230p8rsf	283	9	confirm	confirm	VB
cord-269011-230p8rsf	283	10	this	this	DT
cord-269011-230p8rsf	283	11	posttranslational	posttranslational	JJ
cord-269011-230p8rsf	283	12	modification	modification	NN
cord-269011-230p8rsf	283	13	(	(	-LRB-
cord-269011-230p8rsf	283	14	Godet	Godet	NNP
cord-269011-230p8rsf	283	15	et	et	NNP
cord-269011-230p8rsf	283	16	al	al	NNP
cord-269011-230p8rsf	283	17	.	.	NNP
cord-269011-230p8rsf	283	18	,	,	,
cord-269011-230p8rsf	283	19	1992	1992	CD
cord-269011-230p8rsf	283	20	;	;	:
cord-269011-230p8rsf	283	21	Raamsman	Raamsman	NNP
cord-269011-230p8rsf	283	22	et	et	NNP
cord-269011-230p8rsf	283	23	al	al	NNP
cord-269011-230p8rsf	283	24	.	.	.
cord-269011-230p8rsf	284	1	,	,	,
cord-269011-230p8rsf	284	2	2000	2000	CD
cord-269011-230p8rsf	284	3	)	)	-RRB-
cord-269011-230p8rsf	284	4	.	.	.
cord-269011-230p8rsf	285	1	In	in	IN
cord-269011-230p8rsf	285	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	285	3	-	-	HYPH
cord-269011-230p8rsf	285	4	infected	infect	VBN
cord-269011-230p8rsf	285	5	cells	cell	NNS
cord-269011-230p8rsf	286	1	the	the	DT
cord-269011-230p8rsf	286	2	E	e	NN
cord-269011-230p8rsf	286	3	protein	protein	NN
cord-269011-230p8rsf	286	4	has	have	VBZ
cord-269011-230p8rsf	286	5	been	be	VBN
cord-269011-230p8rsf	286	6	observed	observe	VBN
cord-269011-230p8rsf	286	7	by	by	IN
cord-269011-230p8rsf	286	8	immunofluorescence	immunofluorescence	NN
cord-269011-230p8rsf	286	9	studies	study	NNS
cord-269011-230p8rsf	286	10	to	to	TO
cord-269011-230p8rsf	286	11	occur	occur	VB
cord-269011-230p8rsf	286	12	at	at	IN
cord-269011-230p8rsf	286	13	intracellular	intracellular	JJ
cord-269011-230p8rsf	286	14	membranes	membrane	NNS
cord-269011-230p8rsf	286	15	as	as	RB
cord-269011-230p8rsf	286	16	well	well	RB
cord-269011-230p8rsf	286	17	as	as	IN
cord-269011-230p8rsf	286	18	at	at	IN
cord-269011-230p8rsf	286	19	the	the	DT
cord-269011-230p8rsf	286	20	cell	cell	NN
cord-269011-230p8rsf	286	21	surface	surface	NN
cord-269011-230p8rsf	286	22	(	(	-LRB-
cord-269011-230p8rsf	286	23	Godet	Godet	NNP
cord-269011-230p8rsf	286	24	et	et	NNP
cord-269011-230p8rsf	286	25	al	al	NNP
cord-269011-230p8rsf	286	26	.	.	.
cord-269011-230p8rsf	287	1	,	,	,
cord-269011-230p8rsf	287	2	1992	1992	CD
cord-269011-230p8rsf	287	3	;	;	:
cord-269011-230p8rsf	287	4	Smith	Smith	NNP
cord-269011-230p8rsf	287	5	et	et	NNP
cord-269011-230p8rsf	287	6	al	al	NNP
cord-269011-230p8rsf	287	7	.	.	NNP
cord-269011-230p8rsf	287	8	,	,	,
cord-269011-230p8rsf	287	9	1990	1990	CD
cord-269011-230p8rsf	287	10	;	;	:
cord-269011-230p8rsf	287	11	Tung	Tung	NNP
cord-269011-230p8rsf	287	12	et	et	NNP
cord-269011-230p8rsf	287	13	al	al	NNP
cord-269011-230p8rsf	287	14	.	.	NNP
cord-269011-230p8rsf	287	15	,	,	,
cord-269011-230p8rsf	287	16	1992	1992	CD
cord-269011-230p8rsf	287	17	;	;	:
cord-269011-230p8rsf	287	18	Yu	Yu	NNP
cord-269011-230p8rsf	287	19	et	et	NNP
cord-269011-230p8rsf	287	20	al	al	NNP
cord-269011-230p8rsf	287	21	.	.	NNP
cord-269011-230p8rsf	287	22	,	,	,
cord-269011-230p8rsf	287	23	1994	1994	CD
cord-269011-230p8rsf	287	24	)	)	-RRB-
cord-269011-230p8rsf	287	25	.	.	.
cord-269011-230p8rsf	288	1	When	when	WRB
cord-269011-230p8rsf	288	2	expressed	express	VBN
cord-269011-230p8rsf	288	3	exogenously	exogenously	RB
cord-269011-230p8rsf	288	4	from	from	IN
cord-269011-230p8rsf	288	5	cDNA	cdna	NN
cord-269011-230p8rsf	288	6	,	,	,
cord-269011-230p8rsf	288	7	the	the	DT
cord-269011-230p8rsf	288	8	E	e	NN
cord-269011-230p8rsf	288	9	protein	protein	NN
cord-269011-230p8rsf	288	10	was	be	VBD
cord-269011-230p8rsf	288	11	detected	detect	VBN
cord-269011-230p8rsf	288	12	only	only	RB
cord-269011-230p8rsf	288	13	in	in	IN
cord-269011-230p8rsf	288	14	intracellular	intracellular	JJ
cord-269011-230p8rsf	288	15	organelles	organelle	NNS
cord-269011-230p8rsf	288	16	,	,	,
cord-269011-230p8rsf	288	17	although	although	IN
cord-269011-230p8rsf	288	18	at	at	IN
cord-269011-230p8rsf	288	19	different	different	JJ
cord-269011-230p8rsf	288	20	locations	location	NNS
cord-269011-230p8rsf	288	21	.	.	.
cord-269011-230p8rsf	289	1	The	the	DT
cord-269011-230p8rsf	289	2	MHV	MHV	NNP
cord-269011-230p8rsf	289	3	E	e	NN
cord-269011-230p8rsf	289	4	protein	protein	NN
cord-269011-230p8rsf	289	5	localized	localize	VBN
cord-269011-230p8rsf	289	6	to	to	IN
cord-269011-230p8rsf	289	7	pre	pre	VB
cord-269011-230p8rsf	289	8	-	-	JJ
cord-269011-230p8rsf	289	9	Golgi	golgi	JJ
cord-269011-230p8rsf	289	10	membrane	membrane	NN
cord-269011-230p8rsf	289	11	compartments	compartment	NNS
cord-269011-230p8rsf	289	12	,	,	,
cord-269011-230p8rsf	289	13	as	as	IN
cord-269011-230p8rsf	289	14	was	be	VBD
cord-269011-230p8rsf	289	15	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	289	16	by	by	IN
cord-269011-230p8rsf	289	17	its	-PRON-	PRP$
cord-269011-230p8rsf	289	18	colocalization	colocalization	NN
cord-269011-230p8rsf	289	19	with	with	IN
cord-269011-230p8rsf	289	20	rab-1	rab-1	NNP
cord-269011-230p8rsf	289	21	,	,	,
cord-269011-230p8rsf	289	22	a	a	DT
cord-269011-230p8rsf	289	23	marker	marker	NN
cord-269011-230p8rsf	289	24	for	for	IN
cord-269011-230p8rsf	289	25	the	the	DT
cord-269011-230p8rsf	289	26	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	289	27	reticulum	reticulum	NN
cord-269011-230p8rsf	289	28	and	and	CC
cord-269011-230p8rsf	289	29	the	the	DT
cord-269011-230p8rsf	289	30	ERGIC	ERGIC	NNP
cord-269011-230p8rsf	289	31	,	,	,
cord-269011-230p8rsf	289	32	by	by	IN
cord-269011-230p8rsf	289	33	electron	electron	NN
cord-269011-230p8rsf	289	34	microscopy	microscopy	NN
cord-269011-230p8rsf	289	35	.	.	.
cord-269011-230p8rsf	290	1	The	the	DT
cord-269011-230p8rsf	290	2	IBV	IBV	NNP
cord-269011-230p8rsf	290	3	E	e	NN
cord-269011-230p8rsf	290	4	protein	protein	NN
cord-269011-230p8rsf	290	5	,	,	,
cord-269011-230p8rsf	290	6	tagged	tag	VBN
cord-269011-230p8rsf	290	7	at	at	IN
cord-269011-230p8rsf	290	8	its	-PRON-	PRP$
cord-269011-230p8rsf	290	9	amino	amino	NN
cord-269011-230p8rsf	290	10	terminus	terminus	NN
cord-269011-230p8rsf	290	11	with	with	IN
cord-269011-230p8rsf	290	12	an	an	DT
cord-269011-230p8rsf	290	13	epitope	epitope	NN
cord-269011-230p8rsf	290	14	,	,	,
cord-269011-230p8rsf	290	15	was	be	VBD
cord-269011-230p8rsf	290	16	also	also	RB
cord-269011-230p8rsf	290	17	localized	localize	VBN
cord-269011-230p8rsf	290	18	to	to	TO
cord-269011-230p8rsf	290	19	pre	pre	VB
cord-269011-230p8rsf	290	20	-	-	JJ
cord-269011-230p8rsf	290	21	Golgi	golgi	JJ
cord-269011-230p8rsf	290	22	compartments	compartment	NNS
cord-269011-230p8rsf	290	23	(	(	-LRB-
cord-269011-230p8rsf	290	24	Lim	Lim	NNP
cord-269011-230p8rsf	290	25	and	and	CC
cord-269011-230p8rsf	290	26	Liu	Liu	NNP
cord-269011-230p8rsf	290	27	,	,	,
cord-269011-230p8rsf	290	28	2001	2001	CD
cord-269011-230p8rsf	290	29	)	)	-RRB-
cord-269011-230p8rsf	290	30	.	.	.
cord-269011-230p8rsf	291	1	In	in	IN
cord-269011-230p8rsf	291	2	another	another	DT
cord-269011-230p8rsf	291	3	study	study	NN
cord-269011-230p8rsf	291	4	,	,	,
cord-269011-230p8rsf	291	5	however	however	RB
cord-269011-230p8rsf	291	6	,	,	,
cord-269011-230p8rsf	291	7	the	the	DT
cord-269011-230p8rsf	291	8	IBV	IBV	NNP
cord-269011-230p8rsf	291	9	E	E	NNP
cord-269011-230p8rsf	291	10	protein	protein	NN
cord-269011-230p8rsf	291	11	was	be	VBD
cord-269011-230p8rsf	291	12	shown	show	VBN
cord-269011-230p8rsf	291	13	to	to	TO
cord-269011-230p8rsf	291	14	accumulate	accumulate	VB
cord-269011-230p8rsf	291	15	in	in	IN
cord-269011-230p8rsf	291	16	the	the	DT
cord-269011-230p8rsf	291	17	Golgi	Golgi	NNP
cord-269011-230p8rsf	291	18	apparatus	apparatus	NN
cord-269011-230p8rsf	291	19	,	,	,
cord-269011-230p8rsf	291	20	being	be	VBG
cord-269011-230p8rsf	291	21	distributed	distribute	VBN
cord-269011-230p8rsf	291	22	throughout	throughout	IN
cord-269011-230p8rsf	291	23	the	the	DT
cord-269011-230p8rsf	291	24	complex	complex	JJ
cord-269011-230p8rsf	291	25	Machamer	Machamer	NNP
cord-269011-230p8rsf	291	26	,	,	,
cord-269011-230p8rsf	291	27	2000	2000	CD
cord-269011-230p8rsf	291	28	,	,	,
cord-269011-230p8rsf	291	29	2002	2002	CD
cord-269011-230p8rsf	291	30	)	)	-RRB-
cord-269011-230p8rsf	291	31	.	.	.
cord-269011-230p8rsf	292	1	While	while	IN
cord-269011-230p8rsf	292	2	the	the	DT
cord-269011-230p8rsf	292	3	former	former	JJ
cord-269011-230p8rsf	292	4	study	study	NN
cord-269011-230p8rsf	292	5	identified	identify	VBD
cord-269011-230p8rsf	292	6	an	an	DT
cord-269011-230p8rsf	292	7	ERtargeting	ertargete	VBG
cord-269011-230p8rsf	292	8	signal	signal	NN
cord-269011-230p8rsf	292	9	in	in	IN
cord-269011-230p8rsf	292	10	the	the	DT
cord-269011-230p8rsf	292	11	extreme	extreme	JJ
cord-269011-230p8rsf	292	12	carboxy	carboxy	JJ
cord-269011-230p8rsf	292	13	terminus	terminus	NN
cord-269011-230p8rsf	292	14	of	of	IN
cord-269011-230p8rsf	292	15	the	the	DT
cord-269011-230p8rsf	292	16	E	e	NN
cord-269011-230p8rsf	292	17	protein	protein	NN
cord-269011-230p8rsf	292	18	(	(	-LRB-
cord-269011-230p8rsf	292	19	Lim	Lim	NNP
cord-269011-230p8rsf	292	20	and	and	CC
cord-269011-230p8rsf	292	21	Liu	Liu	NNP
cord-269011-230p8rsf	292	22	,	,	,
cord-269011-230p8rsf	292	23	2001	2001	CD
cord-269011-230p8rsf	292	24	)	)	-RRB-
cord-269011-230p8rsf	292	25	,	,	,
cord-269011-230p8rsf	292	26	the	the	DT
cord-269011-230p8rsf	292	27	latter	latter	JJ
cord-269011-230p8rsf	292	28	studies	study	NNS
cord-269011-230p8rsf	292	29	,	,	,
cord-269011-230p8rsf	292	30	using	use	VBG
cord-269011-230p8rsf	292	31	carboxy	carboxy	JJ
cord-269011-230p8rsf	292	32	-	-	HYPH
cord-269011-230p8rsf	292	33	terminal	terminal	NN
cord-269011-230p8rsf	292	34	truncations	truncation	NNS
cord-269011-230p8rsf	292	35	,	,	,
cord-269011-230p8rsf	292	36	mapped	map	VBD
cord-269011-230p8rsf	292	37	the	the	DT
cord-269011-230p8rsf	292	38	Golgi	Golgi	NNP
cord-269011-230p8rsf	292	39	-	-	HYPH
cord-269011-230p8rsf	292	40	targeting	target	VBG
cord-269011-230p8rsf	292	41	information	information	NN
cord-269011-230p8rsf	292	42	to	to	IN
cord-269011-230p8rsf	292	43	a	a	DT
cord-269011-230p8rsf	292	44	region	region	NN
cord-269011-230p8rsf	292	45	between	between	IN
cord-269011-230p8rsf	292	46	tail	tail	NN
cord-269011-230p8rsf	292	47	residues	residue	NNS
cord-269011-230p8rsf	292	48	13	13	CD
cord-269011-230p8rsf	292	49	and	and	CC
cord-269011-230p8rsf	292	50	63	63	CD
cord-269011-230p8rsf	293	1	(	(	-LRB-
cord-269011-230p8rsf	293	2	Corse	Corse	NNP
cord-269011-230p8rsf	293	3	and	and	CC
cord-269011-230p8rsf	293	4	Machamer	Machamer	NNP
cord-269011-230p8rsf	293	5	,	,	,
cord-269011-230p8rsf	293	6	2002	2002	CD
cord-269011-230p8rsf	293	7	)	)	-RRB-
cord-269011-230p8rsf	293	8	.	.	.
cord-269011-230p8rsf	294	1	In	in	IN
cord-269011-230p8rsf	294	2	addition	addition	NN
cord-269011-230p8rsf	294	3	,	,	,
cord-269011-230p8rsf	294	4	these	these	DT
cord-269011-230p8rsf	294	5	authors	author	NNS
cord-269011-230p8rsf	294	6	showed	show	VBD
cord-269011-230p8rsf	294	7	the	the	DT
cord-269011-230p8rsf	294	8	IBV	IBV	NNP
cord-269011-230p8rsf	294	9	E	e	NN
cord-269011-230p8rsf	294	10	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	294	11	tail	tail	NN
cord-269011-230p8rsf	294	12	to	to	TO
cord-269011-230p8rsf	294	13	be	be	VB
cord-269011-230p8rsf	294	14	necessary	necessary	JJ
cord-269011-230p8rsf	294	15	and	and	CC
cord-269011-230p8rsf	294	16	sufficient	sufficient	JJ
cord-269011-230p8rsf	294	17	for	for	IN
cord-269011-230p8rsf	294	18	Golgi	Golgi	NNP
cord-269011-230p8rsf	294	19	targeting	targeting	NN
cord-269011-230p8rsf	294	20	.	.	.
cord-269011-230p8rsf	295	1	The	the	DT
cord-269011-230p8rsf	295	2	E	e	NN
cord-269011-230p8rsf	295	3	protein	protein	NN
cord-269011-230p8rsf	295	4	was	be	VBD
cord-269011-230p8rsf	295	5	identified	identify	VBN
cord-269011-230p8rsf	295	6	as	as	IN
cord-269011-230p8rsf	295	7	a	a	DT
cord-269011-230p8rsf	295	8	virion	virion	NN
cord-269011-230p8rsf	295	9	component	component	NN
cord-269011-230p8rsf	295	10	relatively	relatively	RB
cord-269011-230p8rsf	295	11	late	late	RB
cord-269011-230p8rsf	295	12	,	,	,
cord-269011-230p8rsf	295	13	due	due	IN
cord-269011-230p8rsf	295	14	to	to	IN
cord-269011-230p8rsf	295	15	its	-PRON-	PRP$
cord-269011-230p8rsf	295	16	low	low	JJ
cord-269011-230p8rsf	295	17	abundance	abundance	NN
cord-269011-230p8rsf	295	18	and	and	CC
cord-269011-230p8rsf	295	19	its	-PRON-	PRP$
cord-269011-230p8rsf	295	20	small	small	JJ
cord-269011-230p8rsf	295	21	size	size	NN
cord-269011-230p8rsf	295	22	(	(	-LRB-
cord-269011-230p8rsf	295	23	Godet	Godet	NNP
cord-269011-230p8rsf	295	24	et	et	NNP
cord-269011-230p8rsf	295	25	al	al	NNP
cord-269011-230p8rsf	295	26	.	.	NNP
cord-269011-230p8rsf	295	27	,	,	,
cord-269011-230p8rsf	295	28	1992	1992	CD
cord-269011-230p8rsf	295	29	;	;	:
cord-269011-230p8rsf	295	30	Liu	Liu	NNP
cord-269011-230p8rsf	295	31	and	and	CC
cord-269011-230p8rsf	295	32	Inglis	Inglis	NNP
cord-269011-230p8rsf	295	33	,	,	,
cord-269011-230p8rsf	295	34	1991	1991	CD
cord-269011-230p8rsf	295	35	;	;	:
cord-269011-230p8rsf	295	36	Yu	Yu	NNP
cord-269011-230p8rsf	295	37	et	et	NNP
cord-269011-230p8rsf	295	38	al	al	NNP
cord-269011-230p8rsf	295	39	.	.	NNP
cord-269011-230p8rsf	295	40	,	,	,
cord-269011-230p8rsf	295	41	1994	1994	CD
cord-269011-230p8rsf	295	42	)	)	-RRB-
cord-269011-230p8rsf	295	43	.	.	.
cord-269011-230p8rsf	296	1	It	-PRON-	PRP
cord-269011-230p8rsf	296	2	was	be	VBD
cord-269011-230p8rsf	296	3	estimated	estimate	VBN
cord-269011-230p8rsf	296	4	to	to	TO
cord-269011-230p8rsf	296	5	occur	occur	VB
cord-269011-230p8rsf	296	6	in	in	IN
cord-269011-230p8rsf	296	7	IBV	IBV	NNP
cord-269011-230p8rsf	296	8	,	,	,
cord-269011-230p8rsf	296	9	TGEV	TGEV	NNP
cord-269011-230p8rsf	296	10	,	,	,
cord-269011-230p8rsf	296	11	and	and	CC
cord-269011-230p8rsf	296	12	MHV	MHV	NNP
cord-269011-230p8rsf	296	13	virions	virion	NNS
cord-269011-230p8rsf	296	14	at	at	IN
cord-269011-230p8rsf	296	15	a	a	DT
cord-269011-230p8rsf	296	16	rate	rate	NN
cord-269011-230p8rsf	296	17	of	of	IN
cord-269011-230p8rsf	296	18	about	about	RB
cord-269011-230p8rsf	296	19	100	100	CD
cord-269011-230p8rsf	296	20	,	,	,
cord-269011-230p8rsf	296	21	20	20	CD
cord-269011-230p8rsf	296	22	,	,	,
cord-269011-230p8rsf	296	23	and	and	CC
cord-269011-230p8rsf	296	24	10	10	CD
cord-269011-230p8rsf	296	25	molecules	molecule	NNS
cord-269011-230p8rsf	296	26	per	per	IN
cord-269011-230p8rsf	296	27	particle	particle	NN
cord-269011-230p8rsf	296	28	,	,	,
cord-269011-230p8rsf	296	29	respectively	respectively	RB
cord-269011-230p8rsf	297	1	(	(	-LRB-
cord-269011-230p8rsf	297	2	Godet	Godet	NNP
cord-269011-230p8rsf	297	3	et	et	NNP
cord-269011-230p8rsf	297	4	al	al	NNP
cord-269011-230p8rsf	297	5	.	.	NNP
cord-269011-230p8rsf	297	6	,	,	,
cord-269011-230p8rsf	297	7	1992	1992	CD
cord-269011-230p8rsf	297	8	;	;	.
cord-269011-230p8rsf	298	1	Liu	Liu	NNP
cord-269011-230p8rsf	298	2	and	and	CC
cord-269011-230p8rsf	298	3	Inglis	Inglis	NNP
cord-269011-230p8rsf	298	4	,	,	,
cord-269011-230p8rsf	298	5	1991	1991	CD
cord-269011-230p8rsf	298	6	;	;	:
cord-269011-230p8rsf	298	7	Vennema	Vennema	NNP
cord-269011-230p8rsf	298	8	et	et	FW
cord-269011-230p8rsf	298	9	al	al	NNP
cord-269011-230p8rsf	298	10	.	.	NNP
cord-269011-230p8rsf	298	11	,	,	,
cord-269011-230p8rsf	298	12	1996	1996	CD
cord-269011-230p8rsf	298	13	)	)	-RRB-
cord-269011-230p8rsf	298	14	.	.	.
cord-269011-230p8rsf	299	1	Because	because	IN
cord-269011-230p8rsf	299	2	of	of	IN
cord-269011-230p8rsf	299	3	its	-PRON-	PRP$
cord-269011-230p8rsf	299	4	low	low	JJ
cord-269011-230p8rsf	299	5	abundance	abundance	NN
cord-269011-230p8rsf	299	6	the	the	DT
cord-269011-230p8rsf	299	7	E	e	NN
cord-269011-230p8rsf	299	8	protein	protein	NN
cord-269011-230p8rsf	299	9	may	may	MD
cord-269011-230p8rsf	299	10	not	not	RB
cord-269011-230p8rsf	299	11	have	have	VB
cord-269011-230p8rsf	299	12	a	a	DT
cord-269011-230p8rsf	299	13	genuine	genuine	JJ
cord-269011-230p8rsf	299	14	structural	structural	JJ
cord-269011-230p8rsf	299	15	function	function	NN
cord-269011-230p8rsf	299	16	in	in	IN
cord-269011-230p8rsf	299	17	the	the	DT
cord-269011-230p8rsf	299	18	virion	virion	NN
cord-269011-230p8rsf	299	19	envelope	envelope	NN
cord-269011-230p8rsf	299	20	.	.	.
cord-269011-230p8rsf	300	1	Rather	rather	RB
cord-269011-230p8rsf	300	2	,	,	,
cord-269011-230p8rsf	300	3	it	-PRON-	PRP
cord-269011-230p8rsf	300	4	may	may	MD
cord-269011-230p8rsf	300	5	have	have	VB
cord-269011-230p8rsf	300	6	a	a	DT
cord-269011-230p8rsf	300	7	morphogenetic	morphogenetic	JJ
cord-269011-230p8rsf	300	8	function	function	NN
cord-269011-230p8rsf	300	9	by	by	IN
cord-269011-230p8rsf	300	10	taking	take	VBG
cord-269011-230p8rsf	300	11	strategic	strategic	JJ
cord-269011-230p8rsf	300	12	positions	position	NNS
cord-269011-230p8rsf	300	13	within	within	IN
cord-269011-230p8rsf	300	14	the	the	DT
cord-269011-230p8rsf	300	15	M	M	NNP
cord-269011-230p8rsf	300	16	protein	protein	NN
cord-269011-230p8rsf	300	17	lattice	lattice	NN
cord-269011-230p8rsf	300	18	to	to	TO
cord-269011-230p8rsf	300	19	generate	generate	VB
cord-269011-230p8rsf	300	20	the	the	DT
cord-269011-230p8rsf	300	21	required	require	VBN
cord-269011-230p8rsf	300	22	membrane	membrane	NN
cord-269011-230p8rsf	300	23	curvature	curvature	NN
cord-269011-230p8rsf	300	24	.	.	.
cord-269011-230p8rsf	301	1	Alternatively	alternatively	RB
cord-269011-230p8rsf	301	2	,	,	,
cord-269011-230p8rsf	301	3	it	-PRON-	PRP
cord-269011-230p8rsf	301	4	may	may	MD
cord-269011-230p8rsf	301	5	serve	serve	VB
cord-269011-230p8rsf	301	6	to	to	TO
cord-269011-230p8rsf	301	7	close	close	VB
cord-269011-230p8rsf	301	8	the	the	DT
cord-269011-230p8rsf	301	9	neck	neck	NN
cord-269011-230p8rsf	301	10	of	of	IN
cord-269011-230p8rsf	301	11	the	the	DT
cord-269011-230p8rsf	301	12	budding	bud	VBG
cord-269011-230p8rsf	301	13	particle	particle	NN
cord-269011-230p8rsf	301	14	as	as	IN
cord-269011-230p8rsf	301	15	it	-PRON-	PRP
cord-269011-230p8rsf	301	16	pinches	pinch	VBZ
cord-269011-230p8rsf	301	17	off	off	RP
cord-269011-230p8rsf	301	18	the	the	DT
cord-269011-230p8rsf	301	19	membrane	membrane	NN
cord-269011-230p8rsf	302	1	(	(	-LRB-
cord-269011-230p8rsf	302	2	Vennema	Vennema	NNP
cord-269011-230p8rsf	302	3	et	et	FW
cord-269011-230p8rsf	302	4	al	al	NNP
cord-269011-230p8rsf	302	5	.	.	NNP
cord-269011-230p8rsf	302	6	,	,	,
cord-269011-230p8rsf	302	7	1996	1996	CD
cord-269011-230p8rsf	302	8	)	)	-RRB-
cord-269011-230p8rsf	302	9	.	.	.
cord-269011-230p8rsf	303	1	Expression	expression	NN
cord-269011-230p8rsf	303	2	of	of	IN
cord-269011-230p8rsf	303	3	the	the	DT
cord-269011-230p8rsf	303	4	E	e	NN
cord-269011-230p8rsf	303	5	protein	protein	NN
cord-269011-230p8rsf	303	6	alone	alone	RB
cord-269011-230p8rsf	303	7	induced	induce	VBD
cord-269011-230p8rsf	303	8	the	the	DT
cord-269011-230p8rsf	303	9	formation	formation	NN
cord-269011-230p8rsf	303	10	of	of	IN
cord-269011-230p8rsf	303	11	characteristic	characteristic	JJ
cord-269011-230p8rsf	303	12	membrane	membrane	NN
cord-269011-230p8rsf	303	13	structures	structure	NNS
cord-269011-230p8rsf	303	14	also	also	RB
cord-269011-230p8rsf	303	15	observed	observe	VBD
cord-269011-230p8rsf	303	16	in	in	IN
cord-269011-230p8rsf	303	17	infected	infected	JJ
cord-269011-230p8rsf	303	18	cells	cell	NNS
cord-269011-230p8rsf	303	19	,	,	,
cord-269011-230p8rsf	303	20	which	which	WDT
cord-269011-230p8rsf	303	21	apparently	apparently	RB
cord-269011-230p8rsf	303	22	consist	consist	VBP
cord-269011-230p8rsf	303	23	of	of	IN
cord-269011-230p8rsf	303	24	masses	masse	NNS
cord-269011-230p8rsf	303	25	of	of	IN
cord-269011-230p8rsf	303	26	tubular	tubular	JJ
cord-269011-230p8rsf	303	27	,	,	,
cord-269011-230p8rsf	303	28	smooth	smooth	JJ
cord-269011-230p8rsf	303	29	convoluted	convoluted	JJ
cord-269011-230p8rsf	303	30	membranes	membrane	NNS
cord-269011-230p8rsf	303	31	(	(	-LRB-
cord-269011-230p8rsf	303	32	David	David	NNP
cord-269011-230p8rsf	303	33	-	-	HYPH
cord-269011-230p8rsf	303	34	Ferreira	Ferreira	NNP
cord-269011-230p8rsf	303	35	and	and	CC
cord-269011-230p8rsf	303	36	Manaker	Manaker	NNP
cord-269011-230p8rsf	303	37	,	,	,
cord-269011-230p8rsf	303	38	1965	1965	CD
cord-269011-230p8rsf	303	39	;	;	:
cord-269011-230p8rsf	304	1	Raamsman	Raamsman	NNP
cord-269011-230p8rsf	304	2	et	et	FW
cord-269011-230p8rsf	304	3	al	al	NNP
cord-269011-230p8rsf	304	4	.	.	.
cord-269011-230p8rsf	305	1	,	,	,
cord-269011-230p8rsf	305	2	2000	2000	CD
cord-269011-230p8rsf	305	3	)	)	-RRB-
cord-269011-230p8rsf	305	4	.	.	.
cord-269011-230p8rsf	306	1	In	in	IN
cord-269011-230p8rsf	306	2	addition	addition	NN
cord-269011-230p8rsf	306	3	,	,	,
cord-269011-230p8rsf	306	4	it	-PRON-	PRP
cord-269011-230p8rsf	306	5	resulted	result	VBD
cord-269011-230p8rsf	306	6	in	in	IN
cord-269011-230p8rsf	306	7	the	the	DT
cord-269011-230p8rsf	306	8	formation	formation	NN
cord-269011-230p8rsf	306	9	of	of	IN
cord-269011-230p8rsf	306	10	vesicles	vesicle	NNS
cord-269011-230p8rsf	306	11	containing	contain	VBG
cord-269011-230p8rsf	306	12	the	the	DT
cord-269011-230p8rsf	306	13	E	e	NN
cord-269011-230p8rsf	306	14	protein	protein	NN
cord-269011-230p8rsf	306	15	,	,	,
cord-269011-230p8rsf	306	16	shown	show	VBN
cord-269011-230p8rsf	306	17	to	to	TO
cord-269011-230p8rsf	306	18	be	be	VB
cord-269011-230p8rsf	306	19	released	release	VBN
cord-269011-230p8rsf	306	20	from	from	IN
cord-269011-230p8rsf	306	21	the	the	DT
cord-269011-230p8rsf	306	22	cells	cell	NNS
cord-269011-230p8rsf	306	23	(	(	-LRB-
cord-269011-230p8rsf	306	24	Corse	Corse	NNP
cord-269011-230p8rsf	306	25	and	and	CC
cord-269011-230p8rsf	306	26	Machamer	Machamer	NNP
cord-269011-230p8rsf	306	27	,	,	,
cord-269011-230p8rsf	306	28	2000	2000	CD
cord-269011-230p8rsf	306	29	;	;	:
cord-269011-230p8rsf	306	30	Maeda	Maeda	NNP
cord-269011-230p8rsf	306	31	et	et	NNP
cord-269011-230p8rsf	306	32	al	al	NNP
cord-269011-230p8rsf	306	33	.	.	NNP
cord-269011-230p8rsf	306	34	,	,	,
cord-269011-230p8rsf	306	35	1999	1999	CD
cord-269011-230p8rsf	306	36	)	)	-RRB-
cord-269011-230p8rsf	306	37	.	.	.
cord-269011-230p8rsf	307	1	MHV	mhv	NN
cord-269011-230p8rsf	307	2	infection	infection	NN
cord-269011-230p8rsf	307	3	induces	induce	VBZ
cord-269011-230p8rsf	307	4	caspase	caspase	NN
cord-269011-230p8rsf	307	5	-	-	HYPH
cord-269011-230p8rsf	307	6	dependent	dependent	JJ
cord-269011-230p8rsf	307	7	apoptosis	apoptosis	NN
cord-269011-230p8rsf	307	8	in	in	IN
cord-269011-230p8rsf	307	9	some	some	DT
cord-269011-230p8rsf	307	10	,	,	,
cord-269011-230p8rsf	307	11	but	but	CC
cord-269011-230p8rsf	307	12	not	not	RB
cord-269011-230p8rsf	307	13	all	all	DT
cord-269011-230p8rsf	307	14	,	,	,
cord-269011-230p8rsf	307	15	cells	cell	NNS
cord-269011-230p8rsf	307	16	.	.	.
cord-269011-230p8rsf	308	1	By	by	IN
cord-269011-230p8rsf	308	2	expressing	express	VBG
cord-269011-230p8rsf	308	3	the	the	DT
cord-269011-230p8rsf	308	4	viral	viral	JJ
cord-269011-230p8rsf	308	5	structural	structural	JJ
cord-269011-230p8rsf	308	6	proteins	protein	NNS
cord-269011-230p8rsf	308	7	separately	separately	RB
cord-269011-230p8rsf	308	8	in	in	IN
cord-269011-230p8rsf	308	9	cells	cell	NNS
cord-269011-230p8rsf	308	10	,	,	,
cord-269011-230p8rsf	308	11	the	the	DT
cord-269011-230p8rsf	308	12	activity	activity	NN
cord-269011-230p8rsf	308	13	could	could	MD
cord-269011-230p8rsf	308	14	be	be	VB
cord-269011-230p8rsf	308	15	attributed	attribute	VBN
cord-269011-230p8rsf	308	16	to	to	IN
cord-269011-230p8rsf	308	17	the	the	DT
cord-269011-230p8rsf	308	18	E	e	NN
cord-269011-230p8rsf	308	19	protein	protein	NN
cord-269011-230p8rsf	308	20	.	.	.
cord-269011-230p8rsf	309	1	Apoptosis	apoptosis	NN
cord-269011-230p8rsf	309	2	induction	induction	NN
cord-269011-230p8rsf	309	3	has	have	VBZ
cord-269011-230p8rsf	309	4	not	not	RB
cord-269011-230p8rsf	309	5	been	be	VBN
cord-269011-230p8rsf	309	6	reported	report	VBN
cord-269011-230p8rsf	309	7	for	for	IN
cord-269011-230p8rsf	309	8	E	e	NN
cord-269011-230p8rsf	309	9	proteins	protein	NNS
cord-269011-230p8rsf	309	10	from	from	IN
cord-269011-230p8rsf	309	11	other	other	JJ
cord-269011-230p8rsf	309	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	309	13	.	.	.
cord-269011-230p8rsf	310	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	310	2	E	e	NN
cord-269011-230p8rsf	310	3	proteins	protein	NNS
cord-269011-230p8rsf	310	4	share	share	VBP
cord-269011-230p8rsf	310	5	structural	structural	JJ
cord-269011-230p8rsf	310	6	similarities	similarity	NNS
cord-269011-230p8rsf	310	7	with	with	IN
cord-269011-230p8rsf	310	8	small	small	JJ
cord-269011-230p8rsf	310	9	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	310	10	membrane	membrane	NN
cord-269011-230p8rsf	310	11	proteins	protein	NNS
cord-269011-230p8rsf	310	12	found	find	VBN
cord-269011-230p8rsf	310	13	in	in	IN
cord-269011-230p8rsf	310	14	other	other	JJ
cord-269011-230p8rsf	310	15	enveloped	envelop	VBN
cord-269011-230p8rsf	310	16	viruses	virus	NNS
cord-269011-230p8rsf	310	17	.	.	.
cord-269011-230p8rsf	311	1	Examples	example	NNS
cord-269011-230p8rsf	311	2	are	be	VBP
cord-269011-230p8rsf	311	3	the	the	DT
cord-269011-230p8rsf	311	4	Vpu	Vpu	NNP
cord-269011-230p8rsf	311	5	protein	protein	NN
cord-269011-230p8rsf	311	6	of	of	IN
cord-269011-230p8rsf	311	7	HIV-1	HIV-1	NNP
cord-269011-230p8rsf	311	8	,	,	,
cord-269011-230p8rsf	311	9	the	the	DT
cord-269011-230p8rsf	311	10	6	6	CD
cord-269011-230p8rsf	311	11	K	K	NNP
cord-269011-230p8rsf	311	12	protein	protein	NN
cord-269011-230p8rsf	311	13	of	of	IN
cord-269011-230p8rsf	311	14	alphaviruses	alphaviruses	NNP
cord-269011-230p8rsf	311	15	,	,	,
cord-269011-230p8rsf	311	16	and	and	CC
cord-269011-230p8rsf	311	17	the	the	DT
cord-269011-230p8rsf	311	18	M2	M2	NNP
cord-269011-230p8rsf	311	19	protein	protein	NN
cord-269011-230p8rsf	311	20	of	of	IN
cord-269011-230p8rsf	311	21	influenza	influenza	NN
cord-269011-230p8rsf	311	22	virus	virus	NN
cord-269011-230p8rsf	311	23	.	.	.
cord-269011-230p8rsf	312	1	These	these	DT
cord-269011-230p8rsf	312	2	proteins	protein	NNS
cord-269011-230p8rsf	312	3	,	,	,
cord-269011-230p8rsf	312	4	also	also	RB
cord-269011-230p8rsf	312	5	known	know	VBN
cord-269011-230p8rsf	312	6	as	as	IN
cord-269011-230p8rsf	312	7	viroporins	viroporin	NNS
cord-269011-230p8rsf	312	8	(	(	-LRB-
cord-269011-230p8rsf	312	9	Gonzalez	Gonzalez	NNP
cord-269011-230p8rsf	312	10	and	and	CC
cord-269011-230p8rsf	312	11	Carrasco	Carrasco	NNP
cord-269011-230p8rsf	312	12	,	,	,
cord-269011-230p8rsf	312	13	2003	2003	CD
cord-269011-230p8rsf	312	14	)	)	-RRB-
cord-269011-230p8rsf	312	15	,	,	,
cord-269011-230p8rsf	312	16	were	be	VBD
cord-269011-230p8rsf	312	17	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	312	18	to	to	TO
cord-269011-230p8rsf	312	19	modify	modify	VB
cord-269011-230p8rsf	312	20	membrane	membrane	NN
cord-269011-230p8rsf	312	21	permeability	permeability	NN
cord-269011-230p8rsf	312	22	and	and	CC
cord-269011-230p8rsf	312	23	to	to	TO
cord-269011-230p8rsf	312	24	help	help	VB
cord-269011-230p8rsf	312	25	the	the	DT
cord-269011-230p8rsf	312	26	efficient	efficient	JJ
cord-269011-230p8rsf	312	27	release	release	NN
cord-269011-230p8rsf	312	28	of	of	IN
cord-269011-230p8rsf	312	29	progeny	progeny	JJ
cord-269011-230p8rsf	312	30	virus	virus	NN
cord-269011-230p8rsf	312	31	.	.	.
cord-269011-230p8rsf	313	1	The	the	DT
cord-269011-230p8rsf	313	2	S	S	NNP
cord-269011-230p8rsf	313	3	protein	protein	NN
cord-269011-230p8rsf	313	4	(	(	-LRB-
cord-269011-230p8rsf	313	5	previously	previously	RB
cord-269011-230p8rsf	313	6	known	know	VBN
cord-269011-230p8rsf	313	7	as	as	IN
cord-269011-230p8rsf	313	8	E2	E2	NNP
cord-269011-230p8rsf	313	9	)	)	-RRB-
cord-269011-230p8rsf	313	10	constitutes	constitute	VBZ
cord-269011-230p8rsf	313	11	the	the	DT
cord-269011-230p8rsf	313	12	spikes	spike	NNS
cord-269011-230p8rsf	313	13	,	,	,
cord-269011-230p8rsf	313	14	the	the	DT
cord-269011-230p8rsf	313	15	hallmark	hallmark	NN
cord-269011-230p8rsf	313	16	of	of	IN
cord-269011-230p8rsf	313	17	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	313	18	under	under	IN
cord-269011-230p8rsf	313	19	the	the	DT
cord-269011-230p8rsf	313	20	electron	electron	NN
cord-269011-230p8rsf	313	21	microscope	microscope	NN
cord-269011-230p8rsf	313	22	.	.	.
cord-269011-230p8rsf	314	1	It	-PRON-	PRP
cord-269011-230p8rsf	314	2	is	be	VBZ
cord-269011-230p8rsf	314	3	the	the	DT
cord-269011-230p8rsf	314	4	major	major	JJ
cord-269011-230p8rsf	314	5	determinant	determinant	NN
cord-269011-230p8rsf	314	6	of	of	IN
cord-269011-230p8rsf	314	7	host	host	NN
cord-269011-230p8rsf	314	8	range	range	NN
cord-269011-230p8rsf	314	9	,	,	,
cord-269011-230p8rsf	314	10	tissue	tissue	NN
cord-269011-230p8rsf	314	11	tropism	tropism	NN
cord-269011-230p8rsf	314	12	,	,	,
cord-269011-230p8rsf	314	13	pathogenesis	pathogenesis	NN
cord-269011-230p8rsf	314	14	,	,	,
cord-269011-230p8rsf	314	15	and	and	CC
cord-269011-230p8rsf	314	16	virulence	virulence	NN
cord-269011-230p8rsf	314	17	.	.	.
cord-269011-230p8rsf	315	1	It	-PRON-	PRP
cord-269011-230p8rsf	315	2	is	be	VBZ
cord-269011-230p8rsf	315	3	a	a	DT
cord-269011-230p8rsf	315	4	relatively	relatively	RB
cord-269011-230p8rsf	315	5	large	large	JJ
cord-269011-230p8rsf	315	6	,	,	,
cord-269011-230p8rsf	315	7	1160-to	1160-to	CD
cord-269011-230p8rsf	315	8	1452-amino	1452-amino	CD
cord-269011-230p8rsf	315	9	acid	acid	NN
cord-269011-230p8rsf	315	10	-	-	HYPH
cord-269011-230p8rsf	315	11	long	long	JJ
cord-269011-230p8rsf	315	12	type	type	NN
cord-269011-230p8rsf	315	13	I	-PRON-	PRP
cord-269011-230p8rsf	315	14	glycoprotein	glycoprotein	VBP
cord-269011-230p8rsf	315	15	with	with	IN
cord-269011-230p8rsf	315	16	a	a	DT
cord-269011-230p8rsf	315	17	cleavable	cleavable	JJ
cord-269011-230p8rsf	315	18	N	n	CD
cord-269011-230p8rsf	315	19	-	-	HYPH
cord-269011-230p8rsf	315	20	terminal	terminal	JJ
cord-269011-230p8rsf	315	21	signal	signal	NN
cord-269011-230p8rsf	315	22	sequence	sequence	NN
cord-269011-230p8rsf	315	23	and	and	CC
cord-269011-230p8rsf	315	24	a	a	DT
cord-269011-230p8rsf	315	25	membrane	membrane	NN
cord-269011-230p8rsf	315	26	-	-	HYPH
cord-269011-230p8rsf	315	27	anchoring	anchor	VBG
cord-269011-230p8rsf	315	28	sequence	sequence	NN
cord-269011-230p8rsf	315	29	followed	follow	VBN
cord-269011-230p8rsf	315	30	by	by	IN
cord-269011-230p8rsf	315	31	a	a	DT
cord-269011-230p8rsf	315	32	short	short	JJ
cord-269011-230p8rsf	315	33	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	315	34	carboxy	carboxy	JJ
cord-269011-230p8rsf	315	35	-	-	HYPH
cord-269011-230p8rsf	315	36	terminal	terminal	NN
cord-269011-230p8rsf	315	37	tail	tail	NN
cord-269011-230p8rsf	315	38	of	of	IN
cord-269011-230p8rsf	315	39	about	about	IN
cord-269011-230p8rsf	315	40	30	30	CD
cord-269011-230p8rsf	315	41	residues	residue	NNS
cord-269011-230p8rsf	315	42	(	(	-LRB-
cord-269011-230p8rsf	315	43	Fig	Fig	NNP
cord-269011-230p8rsf	315	44	.	.	NNP
cord-269011-230p8rsf	315	45	4	4	CD
cord-269011-230p8rsf	315	46	)	)	-RRB-
cord-269011-230p8rsf	315	47	.	.	.
cord-269011-230p8rsf	316	1	When	when	WRB
cord-269011-230p8rsf	316	2	comparing	compare	VBG
cord-269011-230p8rsf	316	3	primary	primary	JJ
cord-269011-230p8rsf	316	4	sequences	sequence	NNS
cord-269011-230p8rsf	316	5	,	,	,
cord-269011-230p8rsf	316	6	the	the	DT
cord-269011-230p8rsf	316	7	S	S	NNP
cord-269011-230p8rsf	316	8	protein	protein	NN
cord-269011-230p8rsf	316	9	shows	show	VBZ
cord-269011-230p8rsf	316	10	two	two	CD
cord-269011-230p8rsf	316	11	faces	face	NNS
cord-269011-230p8rsf	316	12	:	:	:
cord-269011-230p8rsf	316	13	an	an	DT
cord-269011-230p8rsf	316	14	amino	amino	NN
cord-269011-230p8rsf	316	15	-	-	HYPH
cord-269011-230p8rsf	316	16	terminal	terminal	NN
cord-269011-230p8rsf	316	17	half	half	NN
cord-269011-230p8rsf	316	18	with	with	IN
cord-269011-230p8rsf	316	19	hardly	hardly	RB
cord-269011-230p8rsf	316	20	any	any	DT
cord-269011-230p8rsf	316	21	sequence	sequence	NN
cord-269011-230p8rsf	316	22	similarities	similarity	NNS
cord-269011-230p8rsf	316	23	and	and	CC
cord-269011-230p8rsf	316	24	a	a	DT
cord-269011-230p8rsf	316	25	carboxy	carboxy	JJ
cord-269011-230p8rsf	316	26	-	-	HYPH
cord-269011-230p8rsf	316	27	terminal	terminal	NN
cord-269011-230p8rsf	316	28	half	half	NN
cord-269011-230p8rsf	316	29	in	in	IN
cord-269011-230p8rsf	316	30	which	which	WDT
cord-269011-230p8rsf	316	31	regions	region	NNS
cord-269011-230p8rsf	316	32	with	with	IN
cord-269011-230p8rsf	316	33	significant	significant	JJ
cord-269011-230p8rsf	316	34	conservation	conservation	NN
cord-269011-230p8rsf	316	35	can	can	MD
cord-269011-230p8rsf	316	36	be	be	VB
cord-269011-230p8rsf	316	37	observed	observe	VBN
cord-269011-230p8rsf	316	38	(	(	-LRB-
cord-269011-230p8rsf	316	39	de	de	FW
cord-269011-230p8rsf	316	40	Groot	Groot	NNP
cord-269011-230p8rsf	316	41	et	et	FW
cord-269011-230p8rsf	316	42	al	al	NNP
cord-269011-230p8rsf	316	43	.	.	NNP
cord-269011-230p8rsf	316	44	,	,	,
cord-269011-230p8rsf	316	45	1987a	1987a	CD
cord-269011-230p8rsf	316	46	,	,	,
cord-269011-230p8rsf	316	47	b	b	NN
cord-269011-230p8rsf	316	48	;	;	:
cord-269011-230p8rsf	316	49	for	for	IN
cord-269011-230p8rsf	316	50	a	a	DT
cord-269011-230p8rsf	316	51	review	review	NN
cord-269011-230p8rsf	316	52	see	see	VB
cord-269011-230p8rsf	316	53	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	316	54	,	,	,
cord-269011-230p8rsf	316	55	1995	1995	CD
cord-269011-230p8rsf	316	56	)	)	-RRB-
cord-269011-230p8rsf	316	57	,	,	,
cord-269011-230p8rsf	316	58	consistent	consistent	JJ
cord-269011-230p8rsf	316	59	with	with	IN
cord-269011-230p8rsf	316	60	the	the	DT
cord-269011-230p8rsf	316	61	distinctive	distinctive	JJ
cord-269011-230p8rsf	316	62	functions	function	NNS
cord-269011-230p8rsf	316	63	of	of	IN
cord-269011-230p8rsf	316	64	these	these	DT
cord-269011-230p8rsf	316	65	domains	domain	NNS
cord-269011-230p8rsf	316	66	(	(	-LRB-
cord-269011-230p8rsf	316	67	see	see	VB
cord-269011-230p8rsf	316	68	later	later	RB
cord-269011-230p8rsf	316	69	)	)	-RRB-
cord-269011-230p8rsf	316	70	.	.	.
cord-269011-230p8rsf	317	1	The	the	DT
cord-269011-230p8rsf	317	2	S	S	NNP
cord-269011-230p8rsf	317	3	protein	protein	NN
cord-269011-230p8rsf	317	4	is	be	VBZ
cord-269011-230p8rsf	317	5	synthesized	synthesize	VBN
cord-269011-230p8rsf	317	6	as	as	IN
cord-269011-230p8rsf	317	7	a	a	DT
cord-269011-230p8rsf	317	8	heavily	heavily	RB
cord-269011-230p8rsf	317	9	glycosylated	glycosylated	JJ
cord-269011-230p8rsf	317	10	polypeptide	polypeptide	NN
cord-269011-230p8rsf	317	11	as	as	IN
cord-269011-230p8rsf	317	12	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	317	13	by	by	IN
cord-269011-230p8rsf	317	14	the	the	DT
cord-269011-230p8rsf	317	15	susceptibility	susceptibility	NN
cord-269011-230p8rsf	317	16	of	of	IN
cord-269011-230p8rsf	317	17	the	the	DT
cord-269011-230p8rsf	317	18	glycans	glycan	NNS
cord-269011-230p8rsf	317	19	to	to	IN
cord-269011-230p8rsf	317	20	endoglycosidases	endoglycosidase	NNS
cord-269011-230p8rsf	317	21	and	and	CC
cord-269011-230p8rsf	317	22	by	by	IN
cord-269011-230p8rsf	317	23	the	the	DT
cord-269011-230p8rsf	317	24	dramatic	dramatic	JJ
cord-269011-230p8rsf	317	25	effect	effect	NN
cord-269011-230p8rsf	317	26	of	of	IN
cord-269011-230p8rsf	317	27	the	the	DT
cord-269011-230p8rsf	317	28	N	n	CD
cord-269011-230p8rsf	317	29	-	-	HYPH
cord-269011-230p8rsf	317	30	glycosylation	glycosylation	NN
cord-269011-230p8rsf	317	31	inhibitor	inhibitor	NN
cord-269011-230p8rsf	317	32	tunicamycin	tunicamycin	NNS
cord-269011-230p8rsf	317	33	.	.	.
cord-269011-230p8rsf	318	1	The	the	DT
cord-269011-230p8rsf	318	2	number	number	NN
cord-269011-230p8rsf	318	3	of	of	IN
cord-269011-230p8rsf	318	4	potential	potential	JJ
cord-269011-230p8rsf	318	5	N	n	CD
cord-269011-230p8rsf	318	6	-	-	HYPH
cord-269011-230p8rsf	318	7	glycosylation	glycosylation	NN
cord-269011-230p8rsf	318	8	sites	site	NNS
cord-269011-230p8rsf	318	9	ranges	range	VBZ
cord-269011-230p8rsf	318	10	from	from	IN
cord-269011-230p8rsf	318	11	21	21	CD
cord-269011-230p8rsf	318	12	(	(	-LRB-
cord-269011-230p8rsf	318	13	MHV	MHV	NNP
cord-269011-230p8rsf	318	14	)	)	-RRB-
cord-269011-230p8rsf	318	15	to	to	IN
cord-269011-230p8rsf	318	16	35	35	CD
cord-269011-230p8rsf	318	17	[	[	-LRB-
cord-269011-230p8rsf	318	18	feline	feline	JJ
cord-269011-230p8rsf	318	19	infectious	infectious	JJ
cord-269011-230p8rsf	318	20	peritonitis	peritonitis	NN
cord-269011-230p8rsf	318	21	virus	virus	NN
cord-269011-230p8rsf	318	22	(	(	-LRB-
cord-269011-230p8rsf	318	23	FIPV	FIPV	NNP
cord-269011-230p8rsf	318	24	)	)	-RRB-
cord-269011-230p8rsf	318	25	]	]	-RRB-
cord-269011-230p8rsf	318	26	.	.	.
cord-269011-230p8rsf	319	1	The	the	DT
cord-269011-230p8rsf	319	2	S	S	NNP
cord-269011-230p8rsf	319	3	protein	protein	NN
cord-269011-230p8rsf	319	4	has	have	VBZ
cord-269011-230p8rsf	319	5	not	not	RB
cord-269011-230p8rsf	319	6	been	be	VBN
cord-269011-230p8rsf	319	7	reported	report	VBN
cord-269011-230p8rsf	319	8	to	to	TO
cord-269011-230p8rsf	319	9	contain	contain	VB
cord-269011-230p8rsf	319	10	O	o	NN
cord-269011-230p8rsf	319	11	-	-	HYPH
cord-269011-230p8rsf	319	12	linked	link	VBN
cord-269011-230p8rsf	319	13	sugars	sugar	NNS
cord-269011-230p8rsf	319	14	.	.	.
cord-269011-230p8rsf	320	1	Cotranslational	Cotranslational	NNP
cord-269011-230p8rsf	320	2	N	N	NNP
cord-269011-230p8rsf	320	3	-	-	HYPH
cord-269011-230p8rsf	320	4	glycosylation	glycosylation	NN
cord-269011-230p8rsf	320	5	is	be	VBZ
cord-269011-230p8rsf	320	6	an	an	DT
cord-269011-230p8rsf	320	7	essential	essential	JJ
cord-269011-230p8rsf	320	8	requirement	requirement	NN
cord-269011-230p8rsf	320	9	for	for	IN
cord-269011-230p8rsf	320	10	proper	proper	JJ
cord-269011-230p8rsf	320	11	folding	folding	NN
cord-269011-230p8rsf	320	12	,	,	,
cord-269011-230p8rsf	320	13	oligomerization	oligomerization	NN
cord-269011-230p8rsf	320	14	,	,	,
cord-269011-230p8rsf	320	15	and	and	CC
cord-269011-230p8rsf	320	16	transport	transport	NN
cord-269011-230p8rsf	320	17	of	of	IN
cord-269011-230p8rsf	320	18	the	the	DT
cord-269011-230p8rsf	320	19	S	S	NNP
cord-269011-230p8rsf	320	20	protein	protein	NN
cord-269011-230p8rsf	320	21	,	,	,
cord-269011-230p8rsf	320	22	as	as	IN
cord-269011-230p8rsf	320	23	has	have	VBZ
cord-269011-230p8rsf	320	24	also	also	RB
cord-269011-230p8rsf	320	25	been	be	VBN
cord-269011-230p8rsf	320	26	shown	show	VBN
cord-269011-230p8rsf	320	27	for	for	IN
cord-269011-230p8rsf	320	28	other	other	JJ
cord-269011-230p8rsf	320	29	(	(	-LRB-
cord-269011-230p8rsf	320	30	viral	viral	JJ
cord-269011-230p8rsf	320	31	)	)	-RRB-
cord-269011-230p8rsf	320	32	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	320	33	(	(	-LRB-
cord-269011-230p8rsf	320	34	Doms	Doms	NNP
cord-269011-230p8rsf	320	35	et	et	FW
cord-269011-230p8rsf	320	36	al	al	NNP
cord-269011-230p8rsf	320	37	.	.	NNP
cord-269011-230p8rsf	320	38	,	,	,
cord-269011-230p8rsf	320	39	1993	1993	CD
cord-269011-230p8rsf	320	40	)	)	-RRB-
cord-269011-230p8rsf	320	41	.	.	.
cord-269011-230p8rsf	321	1	Growth	growth	NN
cord-269011-230p8rsf	321	2	of	of	IN
cord-269011-230p8rsf	321	3	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	321	4	in	in	IN
cord-269011-230p8rsf	321	5	the	the	DT
cord-269011-230p8rsf	321	6	presence	presence	NN
cord-269011-230p8rsf	321	7	of	of	IN
cord-269011-230p8rsf	321	8	tunicamycin	tunicamycin	NNS
cord-269011-230p8rsf	321	9	resulted	result	VBD
cord-269011-230p8rsf	321	10	in	in	IN
cord-269011-230p8rsf	321	11	the	the	DT
cord-269011-230p8rsf	321	12	production	production	NN
cord-269011-230p8rsf	321	13	of	of	IN
cord-269011-230p8rsf	321	14	spikeless	spikeless	NN
cord-269011-230p8rsf	321	15	,	,	,
cord-269011-230p8rsf	321	16	noninfectious	noninfectious	JJ
cord-269011-230p8rsf	321	17	particles	particle	NNS
cord-269011-230p8rsf	321	18	Mounir	Mounir	NNP
cord-269011-230p8rsf	321	19	and	and	CC
cord-269011-230p8rsf	321	20	Talbot	Talbot	NNP
cord-269011-230p8rsf	321	21	,	,	,
cord-269011-230p8rsf	321	22	1992	1992	CD
cord-269011-230p8rsf	321	23	;	;	.
cord-269011-230p8rsf	322	1	Rottier	Rottier	NNP
cord-269011-230p8rsf	322	2	et	et	NNP
cord-269011-230p8rsf	322	3	al	al	NNP
cord-269011-230p8rsf	322	4	.	.	NNP
cord-269011-230p8rsf	322	5	,	,	,
cord-269011-230p8rsf	322	6	1981a	1981a	CD
cord-269011-230p8rsf	322	7	;	;	:
cord-269011-230p8rsf	322	8	Stern	Stern	NNP
cord-269011-230p8rsf	322	9	and	and	CC
cord-269011-230p8rsf	322	10	Sefton	Sefton	NNP
cord-269011-230p8rsf	322	11	,	,	,
cord-269011-230p8rsf	322	12	1982	1982	CD
cord-269011-230p8rsf	322	13	)	)	-RRB-
cord-269011-230p8rsf	322	14	.	.	.
cord-269011-230p8rsf	323	1	These	these	DT
cord-269011-230p8rsf	323	2	particles	particle	NNS
cord-269011-230p8rsf	323	3	were	be	VBD
cord-269011-230p8rsf	323	4	devoid	devoid	JJ
cord-269011-230p8rsf	323	5	of	of	IN
cord-269011-230p8rsf	323	6	S	s	NN
cord-269011-230p8rsf	323	7	protein	protein	NN
cord-269011-230p8rsf	323	8	,	,	,
cord-269011-230p8rsf	323	9	which	which	WDT
cord-269011-230p8rsf	323	10	was	be	VBD
cord-269011-230p8rsf	323	11	found	find	VBN
cord-269011-230p8rsf	323	12	to	to	TO
cord-269011-230p8rsf	323	13	aggregate	aggregate	VB
cord-269011-230p8rsf	323	14	in	in	IN
cord-269011-230p8rsf	323	15	the	the	DT
cord-269011-230p8rsf	323	16	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	323	17	reticulum	reticulum	NN
cord-269011-230p8rsf	323	18	when	when	WRB
cord-269011-230p8rsf	323	19	glycosylation	glycosylation	NN
cord-269011-230p8rsf	323	20	was	be	VBD
cord-269011-230p8rsf	323	21	inhibited	inhibit	VBN
cord-269011-230p8rsf	323	22	(	(	-LRB-
cord-269011-230p8rsf	323	23	Delmas	Delmas	NNP
cord-269011-230p8rsf	323	24	and	and	CC
cord-269011-230p8rsf	323	25	Laude	Laude	NNP
cord-269011-230p8rsf	323	26	,	,	,
cord-269011-230p8rsf	323	27	1990	1990	CD
cord-269011-230p8rsf	323	28	)	)	-RRB-
cord-269011-230p8rsf	323	29	.	.	.
cord-269011-230p8rsf	324	1	Folding	fold	VBG
cord-269011-230p8rsf	324	2	of	of	IN
cord-269011-230p8rsf	324	3	the	the	DT
cord-269011-230p8rsf	324	4	S	S	NNP
cord-269011-230p8rsf	324	5	protein	protein	NN
cord-269011-230p8rsf	324	6	is	be	VBZ
cord-269011-230p8rsf	324	7	a	a	DT
cord-269011-230p8rsf	324	8	relatively	relatively	RB
cord-269011-230p8rsf	324	9	slow	slow	JJ
cord-269011-230p8rsf	324	10	process	process	NN
cord-269011-230p8rsf	324	11	.	.	.
cord-269011-230p8rsf	325	1	Besides	besides	IN
cord-269011-230p8rsf	325	2	the	the	DT
cord-269011-230p8rsf	325	3	addition	addition	NN
cord-269011-230p8rsf	325	4	of	of	IN
cord-269011-230p8rsf	325	5	oligosaccharides	oligosaccharide	NNS
cord-269011-230p8rsf	325	6	it	-PRON-	PRP
cord-269011-230p8rsf	325	7	involves	involve	VBZ
cord-269011-230p8rsf	325	8	the	the	DT
cord-269011-230p8rsf	325	9	formation	formation	NN
cord-269011-230p8rsf	325	10	and	and	CC
cord-269011-230p8rsf	325	11	rearrangement	rearrangement	NN
cord-269011-230p8rsf	325	12	of	of	IN
cord-269011-230p8rsf	325	13	many	many	JJ
cord-269011-230p8rsf	325	14	intramolecular	intramolecular	JJ
cord-269011-230p8rsf	325	15	disulfide	disulfide	JJ
cord-269011-230p8rsf	325	16	bonds	bond	NNS
cord-269011-230p8rsf	325	17	.	.	.
cord-269011-230p8rsf	326	1	For	for	IN
cord-269011-230p8rsf	326	2	the	the	DT
cord-269011-230p8rsf	326	3	S	S	NNP
cord-269011-230p8rsf	326	4	protein	protein	NN
cord-269011-230p8rsf	326	5	of	of	IN
cord-269011-230p8rsf	326	6	MHV	MHV	NNP
cord-269011-230p8rsf	326	7	-	-	HYPH
cord-269011-230p8rsf	326	8	A59	A59	NNP
cord-269011-230p8rsf	326	9	,	,	,
cord-269011-230p8rsf	326	10	the	the	DT
cord-269011-230p8rsf	326	11	lumenal	lumenal	JJ
cord-269011-230p8rsf	326	12	domain	domain	NN
cord-269011-230p8rsf	326	13	of	of	IN
cord-269011-230p8rsf	326	14	which	which	WDT
cord-269011-230p8rsf	326	15	contains	contain	VBZ
cord-269011-230p8rsf	326	16	42	42	CD
cord-269011-230p8rsf	326	17	cysteine	cysteine	NN
cord-269011-230p8rsf	326	18	residues	residue	NNS
cord-269011-230p8rsf	326	19	,	,	,
cord-269011-230p8rsf	326	20	the	the	DT
cord-269011-230p8rsf	326	21	major	major	JJ
cord-269011-230p8rsf	326	22	conformational	conformational	JJ
cord-269011-230p8rsf	326	23	events	event	NNS
cord-269011-230p8rsf	326	24	appear	appear	VBP
cord-269011-230p8rsf	326	25	to	to	TO
cord-269011-230p8rsf	326	26	take	take	VB
cord-269011-230p8rsf	326	27	about	about	RB
cord-269011-230p8rsf	326	28	20	20	CD
cord-269011-230p8rsf	326	29	min	min	NN
cord-269011-230p8rsf	326	30	during	during	IN
cord-269011-230p8rsf	326	31	which	which	WDT
cord-269011-230p8rsf	326	32	the	the	DT
cord-269011-230p8rsf	326	33	protein	protein	NN
cord-269011-230p8rsf	326	34	passes	pass	VBZ
cord-269011-230p8rsf	326	35	through	through	IN
cord-269011-230p8rsf	326	36	a	a	DT
cord-269011-230p8rsf	326	37	continuous	continuous	JJ
cord-269011-230p8rsf	326	38	spectrum	spectrum	NN
cord-269011-230p8rsf	326	39	of	of	IN
cord-269011-230p8rsf	326	40	folding	folding	NN
cord-269011-230p8rsf	326	41	intermediates	intermediate	NNS
cord-269011-230p8rsf	327	1	(	(	-LRB-
cord-269011-230p8rsf	327	2	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	327	3	et	et	NNP
cord-269011-230p8rsf	327	4	al	al	NNP
cord-269011-230p8rsf	327	5	.	.	NNP
cord-269011-230p8rsf	327	6	,	,	,
cord-269011-230p8rsf	327	7	1993a	1993a	CD
cord-269011-230p8rsf	327	8	)	)	-RRB-
cord-269011-230p8rsf	327	9	.	.	.
cord-269011-230p8rsf	328	1	Folding	folding	NN
cord-269011-230p8rsf	328	2	of	of	IN
cord-269011-230p8rsf	328	3	S	S	NNP
cord-269011-230p8rsf	328	4	is	be	VBZ
cord-269011-230p8rsf	328	5	probably	probably	RB
cord-269011-230p8rsf	328	6	the	the	DT
cord-269011-230p8rsf	328	7	rate	rate	NN
cord-269011-230p8rsf	328	8	-	-	HYPH
cord-269011-230p8rsf	328	9	limiting	limit	VBG
cord-269011-230p8rsf	328	10	step	step	NN
cord-269011-230p8rsf	328	11	in	in	IN
cord-269011-230p8rsf	328	12	the	the	DT
cord-269011-230p8rsf	328	13	process	process	NN
cord-269011-230p8rsf	328	14	of	of	IN
cord-269011-230p8rsf	328	15	oligomerization	oligomerization	NN
cord-269011-230p8rsf	328	16	.	.	.
cord-269011-230p8rsf	329	1	Sufficiently	sufficiently	RB
cord-269011-230p8rsf	329	2	folded	fold	VBN
cord-269011-230p8rsf	329	3	S	S	NNP
cord-269011-230p8rsf	329	4	protein	protein	NN
cord-269011-230p8rsf	329	5	monomers	monomer	NNS
cord-269011-230p8rsf	329	6	associate	associate	VBP
cord-269011-230p8rsf	329	7	in	in	IN
cord-269011-230p8rsf	329	8	the	the	DT
cord-269011-230p8rsf	329	9	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	329	10	reticulum	reticulum	NN
cord-269011-230p8rsf	329	11	to	to	TO
cord-269011-230p8rsf	329	12	form	form	VB
cord-269011-230p8rsf	329	13	trimers	trimer	NNS
cord-269011-230p8rsf	329	14	(	(	-LRB-
cord-269011-230p8rsf	329	15	Delmas	Delmas	NNP
cord-269011-230p8rsf	329	16	and	and	CC
cord-269011-230p8rsf	329	17	Laude	Laude	NNP
cord-269011-230p8rsf	329	18	,	,	,
cord-269011-230p8rsf	329	19	1990	1990	CD
cord-269011-230p8rsf	329	20	;	;	:
cord-269011-230p8rsf	329	21	Lin	Lin	NNP
cord-269011-230p8rsf	329	22	et	et	NNP
cord-269011-230p8rsf	329	23	al	al	NNP
cord-269011-230p8rsf	329	24	.	.	NNP
cord-269011-230p8rsf	329	25	,	,	,
cord-269011-230p8rsf	329	26	2004	2004	CD
cord-269011-230p8rsf	329	27	)	)	-RRB-
cord-269011-230p8rsf	329	28	,	,	,
cord-269011-230p8rsf	329	29	with	with	IN
cord-269011-230p8rsf	329	30	a	a	DT
cord-269011-230p8rsf	329	31	half	half	JJ
cord-269011-230p8rsf	329	32	-	-	HYPH
cord-269011-230p8rsf	329	33	time	time	NN
cord-269011-230p8rsf	329	34	of	of	IN
cord-269011-230p8rsf	329	35	approximately	approximately	RB
cord-269011-230p8rsf	329	36	1	1	CD
cord-269011-230p8rsf	329	37	h	h	NN
cord-269011-230p8rsf	329	38	(	(	-LRB-
cord-269011-230p8rsf	329	39	Delmas	Delmas	NNP
cord-269011-230p8rsf	329	40	and	and	CC
cord-269011-230p8rsf	329	41	Laude	Laude	NNP
cord-269011-230p8rsf	329	42	,	,	,
cord-269011-230p8rsf	329	43	1990	1990	CD
cord-269011-230p8rsf	329	44	;	;	:
cord-269011-230p8rsf	329	45	Vennema	Vennema	NNP
cord-269011-230p8rsf	329	46	et	et	FW
cord-269011-230p8rsf	329	47	al	al	NNP
cord-269011-230p8rsf	329	48	.	.	NNP
cord-269011-230p8rsf	329	49	,	,	,
cord-269011-230p8rsf	329	50	1990a	1990a	CD
cord-269011-230p8rsf	329	51	,	,	,
cord-269011-230p8rsf	329	52	b	b	LS
cord-269011-230p8rsf	329	53	)	)	-RRB-
cord-269011-230p8rsf	329	54	.	.	.
cord-269011-230p8rsf	330	1	Trimerization	Trimerization	NNP
cord-269011-230p8rsf	330	2	is	be	VBZ
cord-269011-230p8rsf	330	3	likely	likely	JJ
cord-269011-230p8rsf	330	4	to	to	TO
cord-269011-230p8rsf	330	5	be	be	VB
cord-269011-230p8rsf	330	6	required	require	VBN
cord-269011-230p8rsf	330	7	for	for	IN
cord-269011-230p8rsf	330	8	export	export	NN
cord-269011-230p8rsf	330	9	out	out	IN
cord-269011-230p8rsf	330	10	of	of	IN
cord-269011-230p8rsf	330	11	the	the	DT
cord-269011-230p8rsf	330	12	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	330	13	reticulum	reticulum	NN
cord-269011-230p8rsf	330	14	.	.	.
cord-269011-230p8rsf	331	1	In	in	IN
cord-269011-230p8rsf	331	2	infected	infected	JJ
cord-269011-230p8rsf	331	3	cells	cell	NNS
cord-269011-230p8rsf	331	4	S	s	NN
cord-269011-230p8rsf	331	5	protein	protein	NN
cord-269011-230p8rsf	331	6	trimers	trimer	NNS
cord-269011-230p8rsf	331	7	interact	interact	VBP
cord-269011-230p8rsf	331	8	with	with	IN
cord-269011-230p8rsf	331	9	M	M	NNP
cord-269011-230p8rsf	331	10	protein	protein	NN
cord-269011-230p8rsf	331	11	and	and	CC
cord-269011-230p8rsf	331	12	perhaps	perhaps	RB
cord-269011-230p8rsf	331	13	also	also	RB
cord-269011-230p8rsf	331	14	with	with	IN
cord-269011-230p8rsf	331	15	E	e	NN
cord-269011-230p8rsf	331	16	protein	protein	NN
cord-269011-230p8rsf	331	17	,	,	,
cord-269011-230p8rsf	331	18	and	and	CC
cord-269011-230p8rsf	331	19	migrate	migrate	VB
cord-269011-230p8rsf	331	20	to	to	IN
cord-269011-230p8rsf	331	21	the	the	DT
cord-269011-230p8rsf	331	22	virus	virus	NN
cord-269011-230p8rsf	331	23	assembly	assembly	NN
cord-269011-230p8rsf	331	24	site	site	NN
cord-269011-230p8rsf	331	25	.	.	.
cord-269011-230p8rsf	332	1	A	a	DT
cord-269011-230p8rsf	332	2	fraction	fraction	NN
cord-269011-230p8rsf	332	3	of	of	IN
cord-269011-230p8rsf	332	4	the	the	DT
cord-269011-230p8rsf	332	5	S	S	NNP
cord-269011-230p8rsf	332	6	protein	protein	NN
cord-269011-230p8rsf	332	7	is	be	VBZ
cord-269011-230p8rsf	332	8	transported	transport	VBN
cord-269011-230p8rsf	332	9	to	to	IN
cord-269011-230p8rsf	332	10	the	the	DT
cord-269011-230p8rsf	332	11	plasma	plasma	NN
cord-269011-230p8rsf	332	12	membrane	membrane	NN
cord-269011-230p8rsf	332	13	where	where	WRB
cord-269011-230p8rsf	332	14	it	-PRON-	PRP
cord-269011-230p8rsf	332	15	can	can	MD
cord-269011-230p8rsf	332	16	cause	cause	VB
cord-269011-230p8rsf	332	17	cell	cell	NN
cord-269011-230p8rsf	332	18	-	-	HYPH
cord-269011-230p8rsf	332	19	cell	cell	NN
cord-269011-230p8rsf	332	20	fusion	fusion	NN
cord-269011-230p8rsf	332	21	,	,	,
cord-269011-230p8rsf	332	22	a	a	DT
cord-269011-230p8rsf	332	23	feature	feature	NN
cord-269011-230p8rsf	332	24	formally	formally	RB
cord-269011-230p8rsf	332	25	attributed	attribute	VBN
cord-269011-230p8rsf	332	26	to	to	IN
cord-269011-230p8rsf	332	27	the	the	DT
cord-269011-230p8rsf	332	28	S	S	NNP
cord-269011-230p8rsf	332	29	protein	protein	NN
cord-269011-230p8rsf	332	30	by	by	IN
cord-269011-230p8rsf	332	31	its	-PRON-	PRP$
cord-269011-230p8rsf	332	32	individual	individual	JJ
cord-269011-230p8rsf	332	33	expression	expression	NN
cord-269011-230p8rsf	332	34	in	in	IN
cord-269011-230p8rsf	332	35	cells	cell	NNS
cord-269011-230p8rsf	332	36	(	(	-LRB-
cord-269011-230p8rsf	332	37	de	de	FW
cord-269011-230p8rsf	332	38	Groot	Groot	NNP
cord-269011-230p8rsf	332	39	et	et	FW
cord-269011-230p8rsf	332	40	al	al	NNP
cord-269011-230p8rsf	332	41	.	.	NNP
cord-269011-230p8rsf	332	42	,	,	,
cord-269011-230p8rsf	332	43	1989	1989	CD
cord-269011-230p8rsf	332	44	;	;	:
cord-269011-230p8rsf	332	45	Pfleiderer	Pfleiderer	NNP
cord-269011-230p8rsf	332	46	et	et	NNP
cord-269011-230p8rsf	332	47	al	al	NNP
cord-269011-230p8rsf	332	48	.	.	NNP
cord-269011-230p8rsf	332	49	,	,	,
cord-269011-230p8rsf	332	50	1990	1990	CD
cord-269011-230p8rsf	332	51	)	)	-RRB-
cord-269011-230p8rsf	332	52	.	.	.
cord-269011-230p8rsf	333	1	Under	under	IN
cord-269011-230p8rsf	333	2	such	such	JJ
cord-269011-230p8rsf	333	3	expression	expression	NN
cord-269011-230p8rsf	333	4	conditions	condition	NNS
cord-269011-230p8rsf	333	5	the	the	DT
cord-269011-230p8rsf	333	6	bulk	bulk	NN
cord-269011-230p8rsf	333	7	of	of	IN
cord-269011-230p8rsf	333	8	the	the	DT
cord-269011-230p8rsf	333	9	S	S	NNP
cord-269011-230p8rsf	333	10	protein	protein	NN
cord-269011-230p8rsf	333	11	remains	remain	VBZ
cord-269011-230p8rsf	333	12	intracellularly	intracellularly	RB
cord-269011-230p8rsf	333	13	(	(	-LRB-
cord-269011-230p8rsf	334	1	Vennema	Vennema	NNP
cord-269011-230p8rsf	334	2	et	et	FW
cord-269011-230p8rsf	334	3	al	al	NNP
cord-269011-230p8rsf	334	4	.	.	.
cord-269011-230p8rsf	335	1	,	,	,
cord-269011-230p8rsf	335	2	1990a	1990a	CD
cord-269011-230p8rsf	335	3	)	)	-RRB-
cord-269011-230p8rsf	335	4	in	in	IN
cord-269011-230p8rsf	335	5	the	the	DT
cord-269011-230p8rsf	335	6	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	335	7	reticulum	reticulum	NN
cord-269011-230p8rsf	335	8	.	.	.
cord-269011-230p8rsf	336	1	Retrieval	retrieval	NN
cord-269011-230p8rsf	336	2	signals	signal	NNS
cord-269011-230p8rsf	336	3	have	have	VBP
cord-269011-230p8rsf	336	4	been	be	VBN
cord-269011-230p8rsf	336	5	identified	identify	VBN
cord-269011-230p8rsf	336	6	in	in	IN
cord-269011-230p8rsf	336	7	the	the	DT
cord-269011-230p8rsf	336	8	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	336	9	tail	tail	NN
cord-269011-230p8rsf	336	10	of	of	IN
cord-269011-230p8rsf	336	11	the	the	DT
cord-269011-230p8rsf	336	12	S	s	NN
cord-269011-230p8rsf	336	13	proteins	protein	NNS
cord-269011-230p8rsf	336	14	from	from	IN
cord-269011-230p8rsf	336	15	coronavirus	coronavirus	NN
cord-269011-230p8rsf	336	16	groups	group	NNS
cord-269011-230p8rsf	336	17	1	1	CD
cord-269011-230p8rsf	336	18	and	and	CC
cord-269011-230p8rsf	336	19	3	3	CD
cord-269011-230p8rsf	336	20	as	as	RB
cord-269011-230p8rsf	336	21	well	well	RB
cord-269011-230p8rsf	336	22	as	as	IN
cord-269011-230p8rsf	336	23	in	in	IN
cord-269011-230p8rsf	336	24	the	the	DT
cord-269011-230p8rsf	336	25	tail	tail	NN
cord-269011-230p8rsf	336	26	of	of	IN
cord-269011-230p8rsf	336	27	the	the	DT
cord-269011-230p8rsf	336	28	SARS	SARS	NNP
cord-269011-230p8rsf	336	29	-	-	HYPH
cord-269011-230p8rsf	336	30	CoV	CoV	NNP
cord-269011-230p8rsf	336	31	S	S	NNP
cord-269011-230p8rsf	336	32	protein	protein	NN
cord-269011-230p8rsf	336	33	,	,	,
cord-269011-230p8rsf	336	34	but	but	CC
cord-269011-230p8rsf	336	35	not	not	RB
cord-269011-230p8rsf	336	36	in	in	IN
cord-269011-230p8rsf	336	37	the	the	DT
cord-269011-230p8rsf	336	38	group	group	NN
cord-269011-230p8rsf	336	39	1	1	CD
cord-269011-230p8rsf	336	40	MHV	MHV	NNP
cord-269011-230p8rsf	336	41	S	S	NNP
cord-269011-230p8rsf	336	42	protein	protein	NN
cord-269011-230p8rsf	337	1	(	(	-LRB-
cord-269011-230p8rsf	337	2	Lontok	Lontok	NNP
cord-269011-230p8rsf	337	3	et	et	FW
cord-269011-230p8rsf	337	4	al	al	NNP
cord-269011-230p8rsf	337	5	.	.	NNP
cord-269011-230p8rsf	337	6	,	,	,
cord-269011-230p8rsf	337	7	2004	2004	CD
cord-269011-230p8rsf	337	8	)	)	-RRB-
cord-269011-230p8rsf	337	9	.	.	.
cord-269011-230p8rsf	338	1	During	during	IN
cord-269011-230p8rsf	338	2	its	-PRON-	PRP$
cord-269011-230p8rsf	338	3	transport	transport	NN
cord-269011-230p8rsf	338	4	to	to	IN
cord-269011-230p8rsf	338	5	the	the	DT
cord-269011-230p8rsf	338	6	cell	cell	NN
cord-269011-230p8rsf	338	7	surface	surface	NN
cord-269011-230p8rsf	338	8	,	,	,
cord-269011-230p8rsf	338	9	either	either	CC
cord-269011-230p8rsf	338	10	alone	alone	RB
cord-269011-230p8rsf	338	11	or	or	CC
cord-269011-230p8rsf	338	12	as	as	IN
cord-269011-230p8rsf	338	13	part	part	NN
cord-269011-230p8rsf	338	14	of	of	IN
cord-269011-230p8rsf	338	15	virions	virion	NNS
cord-269011-230p8rsf	338	16	,	,	,
cord-269011-230p8rsf	338	17	the	the	DT
cord-269011-230p8rsf	338	18	S	S	NNP
cord-269011-230p8rsf	338	19	protein	protein	NN
cord-269011-230p8rsf	338	20	undergoes	undergo	VBZ
cord-269011-230p8rsf	338	21	further	further	JJ
cord-269011-230p8rsf	338	22	modifications	modification	NNS
cord-269011-230p8rsf	338	23	.	.	.
cord-269011-230p8rsf	339	1	The	the	DT
cord-269011-230p8rsf	339	2	N	N	NNP
cord-269011-230p8rsf	339	3	-	-	HYPH
cord-269011-230p8rsf	339	4	linked	link	VBN
cord-269011-230p8rsf	339	5	sugars	sugar	NNS
cord-269011-230p8rsf	339	6	are	be	VBP
cord-269011-230p8rsf	339	7	modified	modify	VBN
cord-269011-230p8rsf	339	8	and	and	CC
cord-269011-230p8rsf	339	9	become	become	VB
cord-269011-230p8rsf	339	10	mature	mature	JJ
cord-269011-230p8rsf	339	11	during	during	IN
cord-269011-230p8rsf	339	12	passage	passage	NN
cord-269011-230p8rsf	339	13	through	through	IN
cord-269011-230p8rsf	339	14	the	the	DT
cord-269011-230p8rsf	339	15	Golgi	Golgi	NNP
cord-269011-230p8rsf	339	16	complex	complex	NN
cord-269011-230p8rsf	339	17	.	.	.
cord-269011-230p8rsf	340	1	The	the	DT
cord-269011-230p8rsf	340	2	MHV	MHV	NNP
cord-269011-230p8rsf	340	3	S	S	NNP
cord-269011-230p8rsf	340	4	protein	protein	NN
cord-269011-230p8rsf	340	5	was	be	VBD
cord-269011-230p8rsf	340	6	shown	show	VBN
cord-269011-230p8rsf	340	7	to	to	TO
cord-269011-230p8rsf	340	8	become	become	VB
cord-269011-230p8rsf	340	9	palmitoylated	palmitoylated	JJ
cord-269011-230p8rsf	340	10	,	,	,
cord-269011-230p8rsf	340	11	a	a	DT
cord-269011-230p8rsf	340	12	modification	modification	NN
cord-269011-230p8rsf	340	13	that	that	WDT
cord-269011-230p8rsf	340	14	may	may	MD
cord-269011-230p8rsf	340	15	already	already	RB
cord-269011-230p8rsf	340	16	take	take	VB
cord-269011-230p8rsf	340	17	place	place	NN
cord-269011-230p8rsf	340	18	in	in	IN
cord-269011-230p8rsf	340	19	the	the	DT
cord-269011-230p8rsf	340	20	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	340	21	reticulum	reticulum	NN
cord-269011-230p8rsf	340	22	(	(	-LRB-
cord-269011-230p8rsf	340	23	van	van	NNP
cord-269011-230p8rsf	340	24	Berlo	Berlo	NNP
cord-269011-230p8rsf	340	25	et	et	NNP
cord-269011-230p8rsf	340	26	al	al	NNP
cord-269011-230p8rsf	340	27	.	.	NNP
cord-269011-230p8rsf	340	28	,	,	,
cord-269011-230p8rsf	340	29	1987	1987	CD
cord-269011-230p8rsf	340	30	)	)	-RRB-
cord-269011-230p8rsf	340	31	.	.	.
cord-269011-230p8rsf	341	1	As	as	IN
cord-269011-230p8rsf	341	2	a	a	DT
cord-269011-230p8rsf	341	3	late	late	JJ
cord-269011-230p8rsf	341	4	step	step	NN
cord-269011-230p8rsf	341	5	the	the	DT
cord-269011-230p8rsf	341	6	S	S	NNP
cord-269011-230p8rsf	341	7	protein	protein	NN
cord-269011-230p8rsf	341	8	can	can	MD
cord-269011-230p8rsf	341	9	be	be	VB
cord-269011-230p8rsf	341	10	cleaved	cleave	VBN
cord-269011-230p8rsf	341	11	.	.	.
cord-269011-230p8rsf	342	1	A	a	DT
cord-269011-230p8rsf	342	2	basic	basic	JJ
cord-269011-230p8rsf	342	3	amino	amino	NN
cord-269011-230p8rsf	342	4	acid	acid	NN
cord-269011-230p8rsf	342	5	sequence	sequence	NN
cord-269011-230p8rsf	342	6	resembling	resemble	VBG
cord-269011-230p8rsf	342	7	the	the	DT
cord-269011-230p8rsf	342	8	furin	furin	NN
cord-269011-230p8rsf	342	9	consensus	consensus	NN
cord-269011-230p8rsf	342	10	sequence	sequence	NN
cord-269011-230p8rsf	342	11	motif	motif	NN
cord-269011-230p8rsf	342	12	(	(	-LRB-
cord-269011-230p8rsf	342	13	RXR	RXR	NNP
cord-269011-230p8rsf	342	14	/	/	SYM
cord-269011-230p8rsf	342	15	KR	KR	NNP
cord-269011-230p8rsf	342	16	)	)	-RRB-
cord-269011-230p8rsf	342	17	occurs	occur	VBZ
cord-269011-230p8rsf	342	18	approximately	approximately	RB
cord-269011-230p8rsf	342	19	in	in	IN
cord-269011-230p8rsf	342	20	the	the	DT
cord-269011-230p8rsf	342	21	middle	middle	NN
cord-269011-230p8rsf	342	22	of	of	IN
cord-269011-230p8rsf	342	23	the	the	DT
cord-269011-230p8rsf	342	24	protein	protein	NN
cord-269011-230p8rsf	342	25	and	and	CC
cord-269011-230p8rsf	342	26	was	be	VBD
cord-269011-230p8rsf	342	27	shown	show	VBN
cord-269011-230p8rsf	342	28	to	to	TO
cord-269011-230p8rsf	342	29	be	be	VB
cord-269011-230p8rsf	342	30	the	the	DT
cord-269011-230p8rsf	342	31	target	target	NN
cord-269011-230p8rsf	342	32	of	of	IN
cord-269011-230p8rsf	342	33	a	a	DT
cord-269011-230p8rsf	342	34	furin	furin	NN
cord-269011-230p8rsf	342	35	-	-	HYPH
cord-269011-230p8rsf	342	36	like	like	JJ
cord-269011-230p8rsf	342	37	enzyme	enzyme	NN
cord-269011-230p8rsf	342	38	in	in	IN
cord-269011-230p8rsf	342	39	the	the	DT
cord-269011-230p8rsf	342	40	case	case	NN
cord-269011-230p8rsf	342	41	of	of	IN
cord-269011-230p8rsf	342	42	MHV	MHV	NNP
cord-269011-230p8rsf	342	43	-	-	HYPH
cord-269011-230p8rsf	342	44	A59	A59	NNP
cord-269011-230p8rsf	342	45	(	(	-LRB-
cord-269011-230p8rsf	342	46	de	de	FW
cord-269011-230p8rsf	342	47	Haan	Haan	NNP
cord-269011-230p8rsf	342	48	et	et	FW
cord-269011-230p8rsf	342	49	al	al	NNP
cord-269011-230p8rsf	342	50	.	.	NNP
cord-269011-230p8rsf	342	51	,	,	,
cord-269011-230p8rsf	342	52	2004	2004	CD
cord-269011-230p8rsf	342	53	)	)	-RRB-
cord-269011-230p8rsf	342	54	.	.	.
cord-269011-230p8rsf	343	1	Cleavage	cleavage	NN
cord-269011-230p8rsf	343	2	has	have	VBZ
cord-269011-230p8rsf	343	3	been	be	VBN
cord-269011-230p8rsf	343	4	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	343	5	for	for	IN
cord-269011-230p8rsf	343	6	S	s	NN
cord-269011-230p8rsf	343	7	proteins	protein	NNS
cord-269011-230p8rsf	343	8	from	from	IN
cord-269011-230p8rsf	343	9	coronavirus	coronavirus	NN
cord-269011-230p8rsf	343	10	groups	group	NNS
cord-269011-230p8rsf	343	11	2	2	CD
cord-269011-230p8rsf	343	12	and	and	CC
cord-269011-230p8rsf	343	13	3	3	CD
cord-269011-230p8rsf	343	14	,	,	,
cord-269011-230p8rsf	343	15	but	but	CC
cord-269011-230p8rsf	343	16	not	not	RB
cord-269011-230p8rsf	343	17	for	for	IN
cord-269011-230p8rsf	343	18	S	s	NN
cord-269011-230p8rsf	343	19	proteins	protein	NNS
cord-269011-230p8rsf	343	20	from	from	IN
cord-269011-230p8rsf	343	21	group	group	NN
cord-269011-230p8rsf	343	22	1	1	CD
cord-269011-230p8rsf	343	23	viruses	virus	NNS
cord-269011-230p8rsf	343	24	(	(	-LRB-
cord-269011-230p8rsf	343	25	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	343	26	,	,	,
cord-269011-230p8rsf	343	27	1995	1995	CD
cord-269011-230p8rsf	343	28	)	)	-RRB-
cord-269011-230p8rsf	343	29	or	or	CC
cord-269011-230p8rsf	343	30	from	from	IN
cord-269011-230p8rsf	343	31	SARS	SARS	NNP
cord-269011-230p8rsf	343	32	-	-	HYPH
cord-269011-230p8rsf	343	33	CoV	CoV	NNP
cord-269011-230p8rsf	344	1	(	(	-LRB-
cord-269011-230p8rsf	344	2	Bisht	Bisht	NNP
cord-269011-230p8rsf	344	3	et	et	NNP
cord-269011-230p8rsf	344	4	al	al	NNP
cord-269011-230p8rsf	344	5	.	.	.
cord-269011-230p8rsf	345	1	,	,	,
cord-269011-230p8rsf	345	2	2004	2004	CD
cord-269011-230p8rsf	345	3	)	)	-RRB-
cord-269011-230p8rsf	345	4	.	.	.
cord-269011-230p8rsf	346	1	The	the	DT
cord-269011-230p8rsf	346	2	resulting	result	VBG
cord-269011-230p8rsf	346	3	amino	amino	NN
cord-269011-230p8rsf	346	4	-	-	HYPH
cord-269011-230p8rsf	346	5	terminal	terminal	NN
cord-269011-230p8rsf	346	6	S1	s1	NN
cord-269011-230p8rsf	346	7	subunit	subunit	NN
cord-269011-230p8rsf	346	8	and	and	CC
cord-269011-230p8rsf	346	9	the	the	DT
cord-269011-230p8rsf	346	10	membrane	membrane	NN
cord-269011-230p8rsf	346	11	-	-	HYPH
cord-269011-230p8rsf	346	12	anchored	anchor	VBN
cord-269011-230p8rsf	346	13	S2	S2	NNP
cord-269011-230p8rsf	346	14	subunit	subunit	NN
cord-269011-230p8rsf	346	15	remain	remain	VBP
cord-269011-230p8rsf	346	16	noncovalently	noncovalently	RB
cord-269011-230p8rsf	346	17	linked	link	VBN
cord-269011-230p8rsf	346	18	.	.	.
cord-269011-230p8rsf	347	1	It	-PRON-	PRP
cord-269011-230p8rsf	347	2	has	have	VBZ
cord-269011-230p8rsf	347	3	been	be	VBN
cord-269011-230p8rsf	347	4	suggested	suggest	VBN
cord-269011-230p8rsf	347	5	that	that	IN
cord-269011-230p8rsf	347	6	the	the	DT
cord-269011-230p8rsf	347	7	S1	S1	NNP
cord-269011-230p8rsf	347	8	subunit	subunit	NN
cord-269011-230p8rsf	347	9	constitutes	constitute	VBZ
cord-269011-230p8rsf	347	10	the	the	DT
cord-269011-230p8rsf	347	11	globular	globular	JJ
cord-269011-230p8rsf	347	12	head	head	NN
cord-269011-230p8rsf	347	13	,	,	,
cord-269011-230p8rsf	347	14	whereas	whereas	IN
cord-269011-230p8rsf	347	15	the	the	DT
cord-269011-230p8rsf	347	16	S2	S2	NNP
cord-269011-230p8rsf	347	17	subunit	subunit	NN
cord-269011-230p8rsf	347	18	forms	form	VBZ
cord-269011-230p8rsf	347	19	the	the	DT
cord-269011-230p8rsf	347	20	stalk	stalk	NN
cord-269011-230p8rsf	347	21	-	-	HYPH
cord-269011-230p8rsf	347	22	like	like	JJ
cord-269011-230p8rsf	347	23	region	region	NN
cord-269011-230p8rsf	347	24	of	of	IN
cord-269011-230p8rsf	347	25	the	the	DT
cord-269011-230p8rsf	347	26	spike	spike	NN
cord-269011-230p8rsf	347	27	(	(	-LRB-
cord-269011-230p8rsf	347	28	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	347	29	,	,	,
cord-269011-230p8rsf	347	30	1983b	1983b	CD
cord-269011-230p8rsf	347	31	;	;	:
cord-269011-230p8rsf	347	32	de	de	FW
cord-269011-230p8rsf	347	33	Groot	Groot	NNP
cord-269011-230p8rsf	347	34	et	et	NNP
cord-269011-230p8rsf	347	35	al	al	NNP
cord-269011-230p8rsf	347	36	.	.	NNP
cord-269011-230p8rsf	347	37	,	,	,
cord-269011-230p8rsf	347	38	1987a	1987a	CD
cord-269011-230p8rsf	347	39	,	,	,
cord-269011-230p8rsf	347	40	b	b	LS
cord-269011-230p8rsf	347	41	)	)	-RRB-
cord-269011-230p8rsf	347	42	.	.	.
cord-269011-230p8rsf	348	1	The	the	DT
cord-269011-230p8rsf	348	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	348	3	S	s	NN
cord-269011-230p8rsf	348	4	protein	protein	NN
cord-269011-230p8rsf	348	5	has	have	VBZ
cord-269011-230p8rsf	348	6	two	two	CD
cord-269011-230p8rsf	348	7	functions	function	NNS
cord-269011-230p8rsf	348	8	,	,	,
cord-269011-230p8rsf	348	9	which	which	WDT
cord-269011-230p8rsf	348	10	appear	appear	VBP
cord-269011-230p8rsf	348	11	to	to	TO
cord-269011-230p8rsf	348	12	be	be	VB
cord-269011-230p8rsf	348	13	spatially	spatially	RB
cord-269011-230p8rsf	348	14	separated	separate	VBN
cord-269011-230p8rsf	348	15	.	.	.
cord-269011-230p8rsf	349	1	The	the	DT
cord-269011-230p8rsf	349	2	S1	s1	NN
cord-269011-230p8rsf	349	3	subunit	subunit	NN
cord-269011-230p8rsf	349	4	(	(	-LRB-
cord-269011-230p8rsf	349	5	or	or	CC
cord-269011-230p8rsf	349	6	the	the	DT
cord-269011-230p8rsf	349	7	equivalent	equivalent	JJ
cord-269011-230p8rsf	349	8	part	part	NN
cord-269011-230p8rsf	349	9	in	in	IN
cord-269011-230p8rsf	349	10	viruses	virus	NNS
cord-269011-230p8rsf	349	11	with	with	IN
cord-269011-230p8rsf	349	12	uncleaved	uncleaved	NNP
cord-269011-230p8rsf	349	13	S	S	NNP
cord-269011-230p8rsf	349	14	protein	protein	NN
cord-269011-230p8rsf	349	15	)	)	-RRB-
cord-269011-230p8rsf	349	16	is	be	VBZ
cord-269011-230p8rsf	349	17	responsible	responsible	JJ
cord-269011-230p8rsf	349	18	for	for	IN
cord-269011-230p8rsf	349	19	receptor	receptor	NN
cord-269011-230p8rsf	349	20	binding	binding	NN
cord-269011-230p8rsf	349	21	,	,	,
cord-269011-230p8rsf	349	22	and	and	CC
cord-269011-230p8rsf	349	23	the	the	DT
cord-269011-230p8rsf	349	24	S2	S2	NNP
cord-269011-230p8rsf	349	25	subunit	subunit	NN
cord-269011-230p8rsf	349	26	is	be	VBZ
cord-269011-230p8rsf	349	27	responsible	responsible	JJ
cord-269011-230p8rsf	349	28	for	for	IN
cord-269011-230p8rsf	349	29	membrane	membrane	NN
cord-269011-230p8rsf	349	30	fusion	fusion	NN
cord-269011-230p8rsf	349	31	.	.	.
cord-269011-230p8rsf	350	1	For	for	IN
cord-269011-230p8rsf	350	2	several	several	JJ
cord-269011-230p8rsf	350	3	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	350	4	the	the	DT
cord-269011-230p8rsf	350	5	receptor	receptor	NN
cord-269011-230p8rsf	350	6	-	-	HYPH
cord-269011-230p8rsf	350	7	binding	bind	VBG
cord-269011-230p8rsf	350	8	site	site	NN
cord-269011-230p8rsf	350	9	in	in	IN
cord-269011-230p8rsf	350	10	S1	S1	NNP
cord-269011-230p8rsf	350	11	has	have	VBZ
cord-269011-230p8rsf	350	12	been	be	VBN
cord-269011-230p8rsf	350	13	mapped	map	VBN
cord-269011-230p8rsf	350	14	.	.	.
cord-269011-230p8rsf	351	1	For	for	IN
cord-269011-230p8rsf	351	2	MHV	MHV	NNP
cord-269011-230p8rsf	351	3	strain	strain	NN
cord-269011-230p8rsf	351	4	JHM	JHM	NNP
cord-269011-230p8rsf	352	1	(	(	-LRB-
cord-269011-230p8rsf	352	2	MHV	MHV	NNP
cord-269011-230p8rsf	352	3	-	-	HYPH
cord-269011-230p8rsf	352	4	JHM	JHM	NNP
cord-269011-230p8rsf	352	5	)	)	-RRB-
cord-269011-230p8rsf	353	1	,	,	,
cord-269011-230p8rsf	353	2	for	for	IN
cord-269011-230p8rsf	353	3	instance	instance	NN
cord-269011-230p8rsf	353	4	,	,	,
cord-269011-230p8rsf	353	5	it	-PRON-	PRP
cord-269011-230p8rsf	353	6	was	be	VBD
cord-269011-230p8rsf	353	7	located	locate	VBN
cord-269011-230p8rsf	353	8	in	in	IN
cord-269011-230p8rsf	353	9	the	the	DT
cord-269011-230p8rsf	353	10	domain	domain	NN
cord-269011-230p8rsf	353	11	composed	compose	VBN
cord-269011-230p8rsf	353	12	of	of	IN
cord-269011-230p8rsf	353	13	the	the	DT
cord-269011-230p8rsf	353	14	amino	amino	NN
cord-269011-230p8rsf	353	15	-	-	HYPH
cord-269011-230p8rsf	353	16	terminal	terminal	NN
cord-269011-230p8rsf	353	17	330	330	CD
cord-269011-230p8rsf	353	18	residues	residue	NNS
cord-269011-230p8rsf	353	19	of	of	IN
cord-269011-230p8rsf	353	20	the	the	DT
cord-269011-230p8rsf	353	21	S	S	NNP
cord-269011-230p8rsf	353	22	molecule	molecule	NN
cord-269011-230p8rsf	353	23	(	(	-LRB-
cord-269011-230p8rsf	353	24	Kubo	Kubo	NNP
cord-269011-230p8rsf	353	25	et	et	NNP
cord-269011-230p8rsf	353	26	al	al	NNP
cord-269011-230p8rsf	353	27	.	.	NNP
cord-269011-230p8rsf	353	28	,	,	,
cord-269011-230p8rsf	353	29	1994	1994	CD
cord-269011-230p8rsf	353	30	)	)	-RRB-
cord-269011-230p8rsf	353	31	,	,	,
cord-269011-230p8rsf	353	32	residues	residue	VBZ
cord-269011-230p8rsf	353	33	62	62	CD
cord-269011-230p8rsf	353	34	-	-	SYM
cord-269011-230p8rsf	353	35	65	65	CD
cord-269011-230p8rsf	353	36	and	and	CC
cord-269011-230p8rsf	353	37	214	214	CD
cord-269011-230p8rsf	353	38	-	-	SYM
cord-269011-230p8rsf	353	39	216	216	CD
cord-269011-230p8rsf	353	40	being	be	VBG
cord-269011-230p8rsf	353	41	particularly	particularly	RB
cord-269011-230p8rsf	353	42	important	important	JJ
cord-269011-230p8rsf	354	1	(	(	-LRB-
cord-269011-230p8rsf	354	2	Saeki	Saeki	NNP
cord-269011-230p8rsf	354	3	et	et	FW
cord-269011-230p8rsf	354	4	al	al	NNP
cord-269011-230p8rsf	354	5	.	.	NNP
cord-269011-230p8rsf	354	6	,	,	,
cord-269011-230p8rsf	354	7	1997	1997	CD
cord-269011-230p8rsf	354	8	;	;	:
cord-269011-230p8rsf	354	9	Suzuki	Suzuki	NNP
cord-269011-230p8rsf	354	10	and	and	CC
cord-269011-230p8rsf	354	11	Taguchi	Taguchi	NNP
cord-269011-230p8rsf	354	12	,	,	,
cord-269011-230p8rsf	354	13	1996	1996	CD
cord-269011-230p8rsf	354	14	)	)	-RRB-
cord-269011-230p8rsf	354	15	.	.	.
cord-269011-230p8rsf	355	1	This	this	DT
cord-269011-230p8rsf	355	2	amino	amino	NN
cord-269011-230p8rsf	355	3	-	-	HYPH
cord-269011-230p8rsf	355	4	terminal	terminal	NN
cord-269011-230p8rsf	355	5	domain	domain	NN
cord-269011-230p8rsf	355	6	also	also	RB
cord-269011-230p8rsf	355	7	determined	determine	VBD
cord-269011-230p8rsf	355	8	CEACAM1	CEACAM1	NNP
cord-269011-230p8rsf	355	9	receptor	receptor	NN
cord-269011-230p8rsf	355	10	specificity	specificity	NN
cord-269011-230p8rsf	355	11	of	of	IN
cord-269011-230p8rsf	355	12	various	various	JJ
cord-269011-230p8rsf	355	13	MHV	MHV	NNP
cord-269011-230p8rsf	355	14	strains	strain	NNS
cord-269011-230p8rsf	355	15	(	(	-LRB-
cord-269011-230p8rsf	355	16	Tsai	Tsai	NNP
cord-269011-230p8rsf	355	17	et	et	NNP
cord-269011-230p8rsf	355	18	al	al	NNP
cord-269011-230p8rsf	355	19	.	.	NNP
cord-269011-230p8rsf	355	20	,	,	,
cord-269011-230p8rsf	355	21	2003	2003	CD
cord-269011-230p8rsf	355	22	)	)	-RRB-
cord-269011-230p8rsf	355	23	.	.	.
cord-269011-230p8rsf	356	1	For	for	IN
cord-269011-230p8rsf	356	2	TGEV	TGEV	NNS
cord-269011-230p8rsf	357	1	(	(	-LRB-
cord-269011-230p8rsf	357	2	Godet	Godet	NNP
cord-269011-230p8rsf	357	3	et	et	NNP
cord-269011-230p8rsf	357	4	al	al	NNP
cord-269011-230p8rsf	357	5	.	.	.
cord-269011-230p8rsf	358	1	,	,	,
cord-269011-230p8rsf	358	2	1994	1994	CD
cord-269011-230p8rsf	358	3	)	)	-RRB-
cord-269011-230p8rsf	358	4	,	,	,
cord-269011-230p8rsf	358	5	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	358	6	Breslin	Breslin	NNP
cord-269011-230p8rsf	358	7	et	et	NNP
cord-269011-230p8rsf	358	8	al	al	NNP
cord-269011-230p8rsf	358	9	.	.	NNP
cord-269011-230p8rsf	358	10	,	,	,
cord-269011-230p8rsf	358	11	2003	2003	CD
cord-269011-230p8rsf	358	12	)	)	-RRB-
cord-269011-230p8rsf	358	13	,	,	,
cord-269011-230p8rsf	358	14	and	and	CC
cord-269011-230p8rsf	358	15	SARS	SARS	NNP
cord-269011-230p8rsf	358	16	-	-	HYPH
cord-269011-230p8rsf	358	17	CoV	CoV	NNP
cord-269011-230p8rsf	358	18	(	(	-LRB-
cord-269011-230p8rsf	358	19	Babcock	Babcock	NNP
cord-269011-230p8rsf	358	20	et	et	NNP
cord-269011-230p8rsf	358	21	al	al	NNP
cord-269011-230p8rsf	358	22	.	.	.
cord-269011-230p8rsf	359	1	,	,	,
cord-269011-230p8rsf	359	2	2004	2004	CD
cord-269011-230p8rsf	359	3	;	;	:
cord-269011-230p8rsf	359	4	Wong	Wong	NNP
cord-269011-230p8rsf	359	5	et	et	NNP
cord-269011-230p8rsf	359	6	al	al	NNP
cord-269011-230p8rsf	359	7	.	.	NNP
cord-269011-230p8rsf	359	8	,	,	,
cord-269011-230p8rsf	359	9	2004	2004	CD
cord-269011-230p8rsf	359	10	)	)	-RRB-
cord-269011-230p8rsf	360	1	the	the	DT
cord-269011-230p8rsf	360	2	receptor	receptor	NN
cord-269011-230p8rsf	360	3	-	-	HYPH
cord-269011-230p8rsf	360	4	binding	bind	VBG
cord-269011-230p8rsf	360	5	domains	domain	NNS
cord-269011-230p8rsf	360	6	have	have	VBP
cord-269011-230p8rsf	360	7	also	also	RB
cord-269011-230p8rsf	360	8	been	be	VBN
cord-269011-230p8rsf	360	9	mapped	map	VBN
cord-269011-230p8rsf	360	10	to	to	IN
cord-269011-230p8rsf	360	11	the	the	DT
cord-269011-230p8rsf	360	12	S1	S1	NNP
cord-269011-230p8rsf	360	13	subunit	subunit	NN
cord-269011-230p8rsf	360	14	,	,	,
cord-269011-230p8rsf	360	15	although	although	IN
cord-269011-230p8rsf	360	16	in	in	IN
cord-269011-230p8rsf	360	17	different	different	JJ
cord-269011-230p8rsf	360	18	regions	region	NNS
cord-269011-230p8rsf	360	19	.	.	.
cord-269011-230p8rsf	361	1	In	in	IN
cord-269011-230p8rsf	361	2	several	several	JJ
cord-269011-230p8rsf	361	3	cases	case	NNS
cord-269011-230p8rsf	361	4	neutralizing	neutralize	VBG
cord-269011-230p8rsf	361	5	antibodies	antibody	NNS
cord-269011-230p8rsf	361	6	were	be	VBD
cord-269011-230p8rsf	361	7	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	361	8	to	to	TO
cord-269011-230p8rsf	361	9	bind	bind	VB
cord-269011-230p8rsf	361	10	the	the	DT
cord-269011-230p8rsf	361	11	receptor	receptor	NN
cord-269011-230p8rsf	361	12	-	-	HYPH
cord-269011-230p8rsf	361	13	binding	bind	VBG
cord-269011-230p8rsf	361	14	domains	domain	NNS
cord-269011-230p8rsf	361	15	and	and	CC
cord-269011-230p8rsf	361	16	to	to	TO
cord-269011-230p8rsf	361	17	prevent	prevent	VB
cord-269011-230p8rsf	361	18	the	the	DT
cord-269011-230p8rsf	361	19	interaction	interaction	NN
cord-269011-230p8rsf	361	20	with	with	IN
cord-269011-230p8rsf	361	21	the	the	DT
cord-269011-230p8rsf	361	22	receptor	receptor	NN
cord-269011-230p8rsf	362	1	(	(	-LRB-
cord-269011-230p8rsf	362	2	Godet	Godet	NNP
cord-269011-230p8rsf	362	3	et	et	NNP
cord-269011-230p8rsf	362	4	al	al	NNP
cord-269011-230p8rsf	362	5	.	.	.
cord-269011-230p8rsf	363	1	,	,	,
cord-269011-230p8rsf	363	2	1994	1994	CD
cord-269011-230p8rsf	363	3	;	;	:
cord-269011-230p8rsf	363	4	Kubo	Kubo	NNP
cord-269011-230p8rsf	363	5	et	et	NNP
cord-269011-230p8rsf	363	6	al	al	NNP
cord-269011-230p8rsf	363	7	.	.	.
cord-269011-230p8rsf	364	1	,	,	,
cord-269011-230p8rsf	364	2	1994	1994	CD
cord-269011-230p8rsf	364	3	;	;	:
cord-269011-230p8rsf	364	4	Sui	Sui	NNP
cord-269011-230p8rsf	364	5	et	et	FW
cord-269011-230p8rsf	364	6	al	al	NNP
cord-269011-230p8rsf	364	7	.	.	NNP
cord-269011-230p8rsf	364	8	,	,	,
cord-269011-230p8rsf	364	9	2004	2004	CD
cord-269011-230p8rsf	364	10	)	)	-RRB-
cord-269011-230p8rsf	364	11	.	.	.
cord-269011-230p8rsf	365	1	The	the	DT
cord-269011-230p8rsf	365	2	interaction	interaction	NN
cord-269011-230p8rsf	365	3	between	between	IN
cord-269011-230p8rsf	365	4	the	the	DT
cord-269011-230p8rsf	365	5	S	S	NNP
cord-269011-230p8rsf	365	6	protein	protein	NN
cord-269011-230p8rsf	365	7	and	and	CC
cord-269011-230p8rsf	365	8	its	-PRON-	PRP$
cord-269011-230p8rsf	365	9	receptor	receptor	NN
cord-269011-230p8rsf	365	10	is	be	VBZ
cord-269011-230p8rsf	365	11	the	the	DT
cord-269011-230p8rsf	365	12	major	major	JJ
cord-269011-230p8rsf	365	13	determinant	determinant	NN
cord-269011-230p8rsf	365	14	for	for	IN
cord-269011-230p8rsf	365	15	virus	virus	NN
cord-269011-230p8rsf	365	16	entry	entry	NN
cord-269011-230p8rsf	365	17	and	and	CC
cord-269011-230p8rsf	365	18	host	host	NN
cord-269011-230p8rsf	365	19	range	range	NN
cord-269011-230p8rsf	365	20	restriction	restriction	NN
cord-269011-230p8rsf	365	21	.	.	.
cord-269011-230p8rsf	366	1	Nonpermissive	nonpermissive	JJ
cord-269011-230p8rsf	366	2	cell	cell	NN
cord-269011-230p8rsf	366	3	lines	line	NNS
cord-269011-230p8rsf	366	4	can	can	MD
cord-269011-230p8rsf	366	5	be	be	VB
cord-269011-230p8rsf	366	6	rendered	render	VBN
cord-269011-230p8rsf	366	7	susceptible	susceptible	JJ
cord-269011-230p8rsf	366	8	by	by	IN
cord-269011-230p8rsf	366	9	making	make	VBG
cord-269011-230p8rsf	366	10	them	-PRON-	PRP
cord-269011-230p8rsf	366	11	express	express	VB
cord-269011-230p8rsf	366	12	the	the	DT
cord-269011-230p8rsf	366	13	receptor	receptor	NN
cord-269011-230p8rsf	366	14	(	(	-LRB-
cord-269011-230p8rsf	366	15	see	see	VB
cord-269011-230p8rsf	366	16	later	later	JJ
cord-269011-230p8rsf	366	17	references	reference	NNS
cord-269011-230p8rsf	366	18	)	)	-RRB-
cord-269011-230p8rsf	366	19	.	.	.
cord-269011-230p8rsf	367	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	367	2	can	can	MD
cord-269011-230p8rsf	367	3	also	also	RB
cord-269011-230p8rsf	367	4	be	be	VB
cord-269011-230p8rsf	367	5	retargeted	retargete	VBN
cord-269011-230p8rsf	367	6	to	to	IN
cord-269011-230p8rsf	367	7	specific	specific	JJ
cord-269011-230p8rsf	367	8	cells	cell	NNS
cord-269011-230p8rsf	367	9	by	by	IN
cord-269011-230p8rsf	367	10	exchanging	exchange	VBG
cord-269011-230p8rsf	367	11	the	the	DT
cord-269011-230p8rsf	367	12	ectodomain	ectodomain	NN
cord-269011-230p8rsf	367	13	of	of	IN
cord-269011-230p8rsf	367	14	the	the	DT
cord-269011-230p8rsf	367	15	S	S	NNP
cord-269011-230p8rsf	367	16	protein	protein	NN
cord-269011-230p8rsf	367	17	for	for	IN
cord-269011-230p8rsf	367	18	that	that	DT
cord-269011-230p8rsf	367	19	of	of	IN
cord-269011-230p8rsf	367	20	an	an	DT
cord-269011-230p8rsf	367	21	appropriate	appropriate	JJ
cord-269011-230p8rsf	367	22	other	other	JJ
cord-269011-230p8rsf	367	23	coronavirus	coronavirus	NN
cord-269011-230p8rsf	367	24	,	,	,
cord-269011-230p8rsf	367	25	as	as	IN
cord-269011-230p8rsf	367	26	was	be	VBD
cord-269011-230p8rsf	367	27	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	367	28	for	for	IN
cord-269011-230p8rsf	367	29	MHV	MHV	NNP
cord-269011-230p8rsf	367	30	(	(	-LRB-
cord-269011-230p8rsf	367	31	Kuo	Kuo	NNP
cord-269011-230p8rsf	367	32	et	et	NNP
cord-269011-230p8rsf	367	33	al	al	NNP
cord-269011-230p8rsf	367	34	.	.	NNP
cord-269011-230p8rsf	367	35	,	,	,
cord-269011-230p8rsf	367	36	2000	2000	CD
cord-269011-230p8rsf	367	37	)	)	-RRB-
cord-269011-230p8rsf	367	38	and	and	CC
cord-269011-230p8rsf	367	39	FIPV	FIPV	NNP
cord-269011-230p8rsf	367	40	(	(	-LRB-
cord-269011-230p8rsf	367	41	Haijema	Haijema	NNP
cord-269011-230p8rsf	367	42	et	et	NNP
cord-269011-230p8rsf	367	43	al	al	NNP
cord-269011-230p8rsf	367	44	.	.	NNP
cord-269011-230p8rsf	367	45	,	,	,
cord-269011-230p8rsf	367	46	2003	2003	CD
cord-269011-230p8rsf	367	47	)	)	-RRB-
cord-269011-230p8rsf	367	48	.	.	.
cord-269011-230p8rsf	368	1	Receptors	receptor	NNS
cord-269011-230p8rsf	368	2	have	have	VBP
cord-269011-230p8rsf	368	3	so	so	RB
cord-269011-230p8rsf	368	4	far	far	RB
cord-269011-230p8rsf	368	5	been	be	VBN
cord-269011-230p8rsf	368	6	identified	identify	VBN
cord-269011-230p8rsf	368	7	for	for	IN
cord-269011-230p8rsf	368	8	the	the	DT
cord-269011-230p8rsf	368	9	group	group	NN
cord-269011-230p8rsf	368	10	2	2	CD
cord-269011-230p8rsf	368	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	368	12	MHV	MHV	NNP
cord-269011-230p8rsf	368	13	(	(	-LRB-
cord-269011-230p8rsf	368	14	CEACAM	CEACAM	NNP
cord-269011-230p8rsf	368	15	;	;	:
cord-269011-230p8rsf	368	16	Dveksler	Dveksler	NNP
cord-269011-230p8rsf	368	17	et	et	NNP
cord-269011-230p8rsf	368	18	al	al	NNP
cord-269011-230p8rsf	368	19	.	.	NNP
cord-269011-230p8rsf	368	20	,	,	,
cord-269011-230p8rsf	368	21	1991	1991	CD
cord-269011-230p8rsf	368	22	Dveksler	Dveksler	NNP
cord-269011-230p8rsf	368	23	et	et	NNP
cord-269011-230p8rsf	368	24	al	al	NNP
cord-269011-230p8rsf	368	25	.	.	NNP
cord-269011-230p8rsf	368	26	,	,	,
cord-269011-230p8rsf	369	1	,	,	,
cord-269011-230p8rsf	369	2	1993	1993	CD
cord-269011-230p8rsf	369	3	Williams	Williams	NNP
cord-269011-230p8rsf	369	4	et	et	NNP
cord-269011-230p8rsf	369	5	al	al	NNP
cord-269011-230p8rsf	369	6	.	.	NNP
cord-269011-230p8rsf	369	7	,	,	,
cord-269011-230p8rsf	369	8	1991	1991	CD
cord-269011-230p8rsf	369	9	)	)	-RRB-
cord-269011-230p8rsf	369	10	;	;	:
cord-269011-230p8rsf	369	11	the	the	DT
cord-269011-230p8rsf	369	12	group	group	NN
cord-269011-230p8rsf	369	13	1	1	CD
cord-269011-230p8rsf	369	14	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	369	15	TGEV	TGEV	NNS
cord-269011-230p8rsf	369	16	and	and	CC
cord-269011-230p8rsf	369	17	porcine	porcine	JJ
cord-269011-230p8rsf	369	18	respiratory	respiratory	JJ
cord-269011-230p8rsf	369	19	coronavirus	coronavirus	NN
cord-269011-230p8rsf	369	20	(	(	-LRB-
cord-269011-230p8rsf	369	21	PRCoV	prcov	NN
cord-269011-230p8rsf	369	22	)	)	-RRB-
cord-269011-230p8rsf	369	23	(	(	-LRB-
cord-269011-230p8rsf	369	24	pAPN	papn	UH
cord-269011-230p8rsf	369	25	;	;	:
cord-269011-230p8rsf	369	26	Delmas	Delmas	NNP
cord-269011-230p8rsf	369	27	et	et	NNP
cord-269011-230p8rsf	369	28	al	al	NNP
cord-269011-230p8rsf	369	29	.	.	NNP
cord-269011-230p8rsf	369	30	,	,	,
cord-269011-230p8rsf	370	1	1992	1992	CD
cord-269011-230p8rsf	370	2	T	T	NNP
cord-269011-230p8rsf	370	3	resnan	resnan	NNP
cord-269011-230p8rsf	370	4	et	et	NNP
cord-269011-230p8rsf	370	5	al	al	NNP
cord-269011-230p8rsf	370	6	.	.	NNP
cord-269011-230p8rsf	370	7	,	,	,
cord-269011-230p8rsf	370	8	1996	1996	CD
cord-269011-230p8rsf	370	9	)	)	-RRB-
cord-269011-230p8rsf	370	10	,	,	,
cord-269011-230p8rsf	370	11	and	and	CC
cord-269011-230p8rsf	370	12	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	370	13	(	(	-LRB-
cord-269011-230p8rsf	371	1	hAPN	hAPN	NNP
cord-269011-230p8rsf	371	2	;	;	:
cord-269011-230p8rsf	371	3	Yeager	Yeager	NNP
cord-269011-230p8rsf	371	4	et	et	NNP
cord-269011-230p8rsf	371	5	al	al	NNP
cord-269011-230p8rsf	371	6	.	.	NNP
cord-269011-230p8rsf	371	7	,	,	,
cord-269011-230p8rsf	371	8	1992	1992	CD
cord-269011-230p8rsf	371	9	)	)	-RRB-
cord-269011-230p8rsf	371	10	;	;	:
cord-269011-230p8rsf	371	11	and	and	CC
cord-269011-230p8rsf	371	12	for	for	IN
cord-269011-230p8rsf	371	13	SARS	SARS	NNP
cord-269011-230p8rsf	371	14	-	-	HYPH
cord-269011-230p8rsf	371	15	CoV	CoV	NNP
cord-269011-230p8rsf	371	16	(	(	-LRB-
cord-269011-230p8rsf	371	17	ACE2	ACE2	NNP
cord-269011-230p8rsf	371	18	;	;	:
cord-269011-230p8rsf	371	19	Li	Li	NNP
cord-269011-230p8rsf	371	20	et	et	NNP
cord-269011-230p8rsf	371	21	al	al	NNP
cord-269011-230p8rsf	371	22	.	.	NNP
cord-269011-230p8rsf	371	23	,	,	,
cord-269011-230p8rsf	371	24	2003	2003	CD
cord-269011-230p8rsf	371	25	)	)	-RRB-
cord-269011-230p8rsf	371	26	.	.	.
cord-269011-230p8rsf	372	1	The	the	DT
cord-269011-230p8rsf	372	2	S	S	NNP
cord-269011-230p8rsf	372	3	proteins	protein	NNS
cord-269011-230p8rsf	372	4	of	of	IN
cord-269011-230p8rsf	372	5	the	the	DT
cord-269011-230p8rsf	372	6	group	group	NN
cord-269011-230p8rsf	372	7	2	2	CD
cord-269011-230p8rsf	372	8	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	372	9	have	have	VBP
cord-269011-230p8rsf	372	10	been	be	VBN
cord-269011-230p8rsf	372	11	observed	observe	VBN
cord-269011-230p8rsf	372	12	to	to	TO
cord-269011-230p8rsf	372	13	exhibit	exhibit	VB
cord-269011-230p8rsf	372	14	hemagglutinating	hemagglutinate	VBG
cord-269011-230p8rsf	372	15	activities	activity	NNS
cord-269011-230p8rsf	372	16	.	.	.
cord-269011-230p8rsf	373	1	Although	although	IN
cord-269011-230p8rsf	373	2	for	for	IN
cord-269011-230p8rsf	373	3	bovine	bovine	JJ
cord-269011-230p8rsf	373	4	coronavirus	coronavirus	NN
cord-269011-230p8rsf	373	5	(	(	-LRB-
cord-269011-230p8rsf	373	6	BCoV	BCoV	NNP
cord-269011-230p8rsf	373	7	)	)	-RRB-
cord-269011-230p8rsf	373	8	,	,	,
cord-269011-230p8rsf	373	9	HCoV	HCoV	NNP
cord-269011-230p8rsf	373	10	-	-	HYPH
cord-269011-230p8rsf	373	11	OC43	OC43	NNP
cord-269011-230p8rsf	373	12	,	,	,
cord-269011-230p8rsf	373	13	and	and	CC
cord-269011-230p8rsf	373	14	hemagglutinating	hemagglutinate	VBG
cord-269011-230p8rsf	373	15	encephalomyelitis	encephalomyelitis	NN
cord-269011-230p8rsf	373	16	virus	virus	NN
cord-269011-230p8rsf	373	17	(	(	-LRB-
cord-269011-230p8rsf	373	18	HEV	HEV	NNP
cord-269011-230p8rsf	373	19	)	)	-RRB-
cord-269011-230p8rsf	373	20	9-O	9-o	CD
cord-269011-230p8rsf	373	21	-	-	HYPH
cord-269011-230p8rsf	373	22	acetylated	acetylated	JJ
cord-269011-230p8rsf	373	23	sialic	sialic	JJ
cord-269011-230p8rsf	373	24	acids	acid	NNS
cord-269011-230p8rsf	373	25	were	be	VBD
cord-269011-230p8rsf	373	26	identified	identify	VBN
cord-269011-230p8rsf	373	27	as	as	IN
cord-269011-230p8rsf	373	28	a	a	DT
cord-269011-230p8rsf	373	29	receptor	receptor	NN
cord-269011-230p8rsf	373	30	determinant	determinant	NN
cord-269011-230p8rsf	373	31	(	(	-LRB-
cord-269011-230p8rsf	373	32	Krempl	Krempl	NNP
cord-269011-230p8rsf	373	33	et	et	FW
cord-269011-230p8rsf	373	34	al	al	NNP
cord-269011-230p8rsf	373	35	.	.	NNP
cord-269011-230p8rsf	373	36	,	,	,
cord-269011-230p8rsf	373	37	1995	1995	CD
cord-269011-230p8rsf	373	38	;	;	:
cord-269011-230p8rsf	373	39	Kunkel	Kunkel	NNP
cord-269011-230p8rsf	373	40	and	and	CC
cord-269011-230p8rsf	373	41	Herrler	Herrler	NNP
cord-269011-230p8rsf	373	42	,	,	,
cord-269011-230p8rsf	373	43	1993	1993	CD
cord-269011-230p8rsf	373	44	;	;	:
cord-269011-230p8rsf	373	45	Schultze	Schultze	NNP
cord-269011-230p8rsf	373	46	and	and	CC
cord-269011-230p8rsf	373	47	Herrler	Herrler	NNP
cord-269011-230p8rsf	373	48	,	,	,
cord-269011-230p8rsf	373	49	1992	1992	CD
cord-269011-230p8rsf	373	50	;	;	:
cord-269011-230p8rsf	373	51	Schultze	Schultze	NNP
cord-269011-230p8rsf	373	52	et	et	NNP
cord-269011-230p8rsf	373	53	al	al	NNP
cord-269011-230p8rsf	373	54	.	.	NNP
cord-269011-230p8rsf	373	55	,	,	,
cord-269011-230p8rsf	373	56	1991a	1991a	CD
cord-269011-230p8rsf	373	57	;	;	:
cord-269011-230p8rsf	373	58	Vlasak	Vlasak	NNP
cord-269011-230p8rsf	373	59	et	et	NNP
cord-269011-230p8rsf	373	60	al	al	NNP
cord-269011-230p8rsf	373	61	.	.	NNP
cord-269011-230p8rsf	373	62	,	,	,
cord-269011-230p8rsf	373	63	1988b	1988b	CD
cord-269011-230p8rsf	373	64	)	)	-RRB-
cord-269011-230p8rsf	373	65	,	,	,
cord-269011-230p8rsf	373	66	specific	specific	JJ
cord-269011-230p8rsf	373	67	receptors	receptor	NNS
cord-269011-230p8rsf	373	68	for	for	IN
cord-269011-230p8rsf	373	69	these	these	DT
cord-269011-230p8rsf	373	70	viruses	virus	NNS
cord-269011-230p8rsf	373	71	have	have	VBP
cord-269011-230p8rsf	373	72	not	not	RB
cord-269011-230p8rsf	373	73	been	be	VBN
cord-269011-230p8rsf	373	74	identified	identify	VBN
cord-269011-230p8rsf	373	75	.	.	.
cord-269011-230p8rsf	374	1	Also	also	RB
cord-269011-230p8rsf	374	2	,	,	,
cord-269011-230p8rsf	374	3	the	the	DT
cord-269011-230p8rsf	374	4	MHV	MHV	NNP
cord-269011-230p8rsf	374	5	S	S	NNP
cord-269011-230p8rsf	374	6	protein	protein	NN
cord-269011-230p8rsf	374	7	appears	appear	VBZ
cord-269011-230p8rsf	374	8	to	to	TO
cord-269011-230p8rsf	374	9	bind	bind	VB
cord-269011-230p8rsf	374	10	sialic	sialic	JJ
cord-269011-230p8rsf	374	11	acid	acid	NN
cord-269011-230p8rsf	374	12	derivatives	derivative	NNS
cord-269011-230p8rsf	374	13	in	in	IN
cord-269011-230p8rsf	374	14	addition	addition	NN
cord-269011-230p8rsf	374	15	to	to	IN
cord-269011-230p8rsf	374	16	its	-PRON-	PRP$
cord-269011-230p8rsf	374	17	specific	specific	JJ
cord-269011-230p8rsf	374	18	receptor	receptor	NN
cord-269011-230p8rsf	374	19	CEACAM	CEACAM	NNP
cord-269011-230p8rsf	374	20	,	,	,
cord-269011-230p8rsf	374	21	which	which	WDT
cord-269011-230p8rsf	374	22	may	may	MD
cord-269011-230p8rsf	374	23	suggest	suggest	VB
cord-269011-230p8rsf	374	24	that	that	IN
cord-269011-230p8rsf	374	25	sialic	sialic	JJ
cord-269011-230p8rsf	374	26	acids	acid	NNS
cord-269011-230p8rsf	374	27	function	function	VBP
cord-269011-230p8rsf	374	28	as	as	IN
cord-269011-230p8rsf	374	29	an	an	DT
cord-269011-230p8rsf	374	30	additional	additional	JJ
cord-269011-230p8rsf	374	31	receptor	receptor	NN
cord-269011-230p8rsf	374	32	determinant	determinant	NN
cord-269011-230p8rsf	374	33	for	for	IN
cord-269011-230p8rsf	374	34	MHV	MHV	NNP
cord-269011-230p8rsf	374	35	-	-	HYPH
cord-269011-230p8rsf	374	36	like	like	JJ
cord-269011-230p8rsf	374	37	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	375	1	(	(	-LRB-
cord-269011-230p8rsf	375	2	Wurzer	Wurzer	NNP
cord-269011-230p8rsf	375	3	et	et	NNP
cord-269011-230p8rsf	375	4	al	al	NNP
cord-269011-230p8rsf	375	5	.	.	NNP
cord-269011-230p8rsf	375	6	,	,	,
cord-269011-230p8rsf	375	7	2002	2002	CD
cord-269011-230p8rsf	375	8	)	)	-RRB-
cord-269011-230p8rsf	375	9	.	.	.
cord-269011-230p8rsf	376	1	The	the	DT
cord-269011-230p8rsf	376	2	ectodomain	ectodomain	NN
cord-269011-230p8rsf	376	3	of	of	IN
cord-269011-230p8rsf	376	4	the	the	DT
cord-269011-230p8rsf	376	5	S2	S2	NNP
cord-269011-230p8rsf	376	6	subunit	subunit	NN
cord-269011-230p8rsf	376	7	,	,	,
cord-269011-230p8rsf	376	8	which	which	WDT
cord-269011-230p8rsf	376	9	is	be	VBZ
cord-269011-230p8rsf	376	10	involved	involve	VBN
cord-269011-230p8rsf	376	11	in	in	IN
cord-269011-230p8rsf	376	12	the	the	DT
cord-269011-230p8rsf	376	13	fusion	fusion	NN
cord-269011-230p8rsf	376	14	process	process	NN
cord-269011-230p8rsf	376	15	,	,	,
cord-269011-230p8rsf	376	16	contains	contain	VBZ
cord-269011-230p8rsf	376	17	two	two	CD
cord-269011-230p8rsf	376	18	heptad	heptad	NN
cord-269011-230p8rsf	376	19	repeat	repeat	NN
cord-269011-230p8rsf	376	20	(	(	-LRB-
cord-269011-230p8rsf	376	21	HR	hr	NN
cord-269011-230p8rsf	376	22	)	)	-RRB-
cord-269011-230p8rsf	376	23	regions	region	NNS
cord-269011-230p8rsf	376	24	(	(	-LRB-
cord-269011-230p8rsf	376	25	de	de	FW
cord-269011-230p8rsf	376	26	Groot	Groot	NNP
cord-269011-230p8rsf	376	27	et	et	FW
cord-269011-230p8rsf	376	28	al	al	NNP
cord-269011-230p8rsf	376	29	.	.	NNP
cord-269011-230p8rsf	376	30	,	,	,
cord-269011-230p8rsf	376	31	1987a	1987a	CD
cord-269011-230p8rsf	376	32	,	,	,
cord-269011-230p8rsf	376	33	b	b	LS
cord-269011-230p8rsf	376	34	)	)	-RRB-
cord-269011-230p8rsf	376	35	,	,	,
cord-269011-230p8rsf	376	36	a	a	DT
cord-269011-230p8rsf	376	37	sequence	sequence	NN
cord-269011-230p8rsf	376	38	motif	motif	NN
cord-269011-230p8rsf	376	39	characteristic	characteristic	NN
cord-269011-230p8rsf	376	40	of	of	IN
cord-269011-230p8rsf	376	41	coiled	coiled	JJ
cord-269011-230p8rsf	376	42	coils	coil	NNS
cord-269011-230p8rsf	376	43	.	.	.
cord-269011-230p8rsf	377	1	Mutations	mutation	NNS
cord-269011-230p8rsf	377	2	in	in	IN
cord-269011-230p8rsf	377	3	the	the	DT
cord-269011-230p8rsf	377	4	first	first	JJ
cord-269011-230p8rsf	377	5	(	(	-LRB-
cord-269011-230p8rsf	377	6	i.e.	i.e.	FW
cord-269011-230p8rsf	377	7	,	,	,
cord-269011-230p8rsf	377	8	membrane	membrane	NN
cord-269011-230p8rsf	377	9	-	-	HYPH
cord-269011-230p8rsf	377	10	distal	distal	JJ
cord-269011-230p8rsf	377	11	)	)	-RRB-
cord-269011-230p8rsf	377	12	HR	hr	NN
cord-269011-230p8rsf	377	13	region	region	NN
cord-269011-230p8rsf	377	14	of	of	IN
cord-269011-230p8rsf	377	15	the	the	DT
cord-269011-230p8rsf	377	16	MHV	MHV	NNP
cord-269011-230p8rsf	377	17	S	S	NNP
cord-269011-230p8rsf	377	18	protein	protein	NN
cord-269011-230p8rsf	377	19	resulted	result	VBD
cord-269011-230p8rsf	377	20	in	in	IN
cord-269011-230p8rsf	377	21	fusion	fusion	NN
cord-269011-230p8rsf	377	22	-	-	HYPH
cord-269011-230p8rsf	377	23	negative	negative	JJ
cord-269011-230p8rsf	377	24	phenotypes	phenotype	NNS
cord-269011-230p8rsf	377	25	(	(	-LRB-
cord-269011-230p8rsf	377	26	Luo	Luo	NNP
cord-269011-230p8rsf	377	27	and	and	CC
cord-269011-230p8rsf	377	28	Weiss	Weiss	NNP
cord-269011-230p8rsf	377	29	,	,	,
cord-269011-230p8rsf	377	30	1998	1998	CD
cord-269011-230p8rsf	377	31	)	)	-RRB-
cord-269011-230p8rsf	377	32	or	or	CC
cord-269011-230p8rsf	377	33	in	in	IN
cord-269011-230p8rsf	377	34	a	a	DT
cord-269011-230p8rsf	377	35	low	low	JJ
cord-269011-230p8rsf	377	36	-	-	HYPH
cord-269011-230p8rsf	377	37	pH	ph	NN
cord-269011-230p8rsf	377	38	dependence	dependence	NN
cord-269011-230p8rsf	377	39	for	for	IN
cord-269011-230p8rsf	377	40	fusion	fusion	NN
cord-269011-230p8rsf	378	1	(	(	-LRB-
cord-269011-230p8rsf	378	2	Gallagher	Gallagher	NNP
cord-269011-230p8rsf	378	3	et	et	NNP
cord-269011-230p8rsf	378	4	al	al	NNP
cord-269011-230p8rsf	378	5	.	.	NNP
cord-269011-230p8rsf	378	6	,	,	,
cord-269011-230p8rsf	378	7	1991	1991	CD
cord-269011-230p8rsf	378	8	)	)	-RRB-
cord-269011-230p8rsf	378	9	,	,	,
cord-269011-230p8rsf	378	10	whereas	whereas	IN
cord-269011-230p8rsf	378	11	mutations	mutation	NNS
cord-269011-230p8rsf	378	12	in	in	IN
cord-269011-230p8rsf	378	13	the	the	DT
cord-269011-230p8rsf	378	14	second	second	JJ
cord-269011-230p8rsf	378	15	HR	hr	NN
cord-269011-230p8rsf	378	16	region	region	NN
cord-269011-230p8rsf	378	17	caused	cause	VBD
cord-269011-230p8rsf	378	18	defects	defect	NNS
cord-269011-230p8rsf	378	19	in	in	IN
cord-269011-230p8rsf	378	20	S	S	NNP
cord-269011-230p8rsf	378	21	protein	protein	NN
cord-269011-230p8rsf	378	22	oligomerization	oligomerization	NN
cord-269011-230p8rsf	378	23	and	and	CC
cord-269011-230p8rsf	378	24	fusion	fusion	NN
cord-269011-230p8rsf	378	25	ability	ability	NN
cord-269011-230p8rsf	378	26	(	(	-LRB-
cord-269011-230p8rsf	378	27	Luo	Luo	NNP
cord-269011-230p8rsf	378	28	et	et	NNP
cord-269011-230p8rsf	378	29	al	al	NNP
cord-269011-230p8rsf	378	30	.	.	NNP
cord-269011-230p8rsf	378	31	,	,	,
cord-269011-230p8rsf	378	32	1999	1999	CD
cord-269011-230p8rsf	378	33	)	)	-RRB-
cord-269011-230p8rsf	378	34	.	.	.
cord-269011-230p8rsf	379	1	A	a	DT
cord-269011-230p8rsf	379	2	fusion	fusion	NN
cord-269011-230p8rsf	379	3	peptide	peptide	NN
cord-269011-230p8rsf	379	4	has	have	VBZ
cord-269011-230p8rsf	379	5	not	not	RB
cord-269011-230p8rsf	379	6	yet	yet	RB
cord-269011-230p8rsf	379	7	been	be	VBN
cord-269011-230p8rsf	379	8	identified	identify	VBN
cord-269011-230p8rsf	379	9	in	in	IN
cord-269011-230p8rsf	379	10	any	any	DT
cord-269011-230p8rsf	379	11	of	of	IN
cord-269011-230p8rsf	379	12	the	the	DT
cord-269011-230p8rsf	379	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	379	14	spike	spike	NN
cord-269011-230p8rsf	379	15	proteins	protein	NNS
cord-269011-230p8rsf	379	16	,	,	,
cord-269011-230p8rsf	379	17	but	but	CC
cord-269011-230p8rsf	379	18	is	be	VBZ
cord-269011-230p8rsf	379	19	predicted	predict	VBN
cord-269011-230p8rsf	379	20	to	to	TO
cord-269011-230p8rsf	379	21	be	be	VB
cord-269011-230p8rsf	379	22	located	locate	VBN
cord-269011-230p8rsf	379	23	at	at	IN
cord-269011-230p8rsf	379	24	(	(	-LRB-
cord-269011-230p8rsf	379	25	Bosch	Bosch	NNP
cord-269011-230p8rsf	379	26	et	et	NNP
cord-269011-230p8rsf	379	27	al	al	NNP
cord-269011-230p8rsf	379	28	.	.	NNP
cord-269011-230p8rsf	379	29	,	,	,
cord-269011-230p8rsf	379	30	2004b	2004b	CD
cord-269011-230p8rsf	379	31	;	;	:
cord-269011-230p8rsf	380	1	Chambers	chamber	NNS
cord-269011-230p8rsf	380	2	et	et	NNP
cord-269011-230p8rsf	380	3	al	al	NNP
cord-269011-230p8rsf	380	4	.	.	NNP
cord-269011-230p8rsf	380	5	,	,	,
cord-269011-230p8rsf	380	6	1990	1990	CD
cord-269011-230p8rsf	380	7	)	)	-RRB-
cord-269011-230p8rsf	380	8	or	or	CC
cord-269011-230p8rsf	381	1	within	within	IN
cord-269011-230p8rsf	381	2	(	(	-LRB-
cord-269011-230p8rsf	381	3	Luo	Luo	NNP
cord-269011-230p8rsf	381	4	and	and	CC
cord-269011-230p8rsf	381	5	Weiss	Weiss	NNP
cord-269011-230p8rsf	381	6	,	,	,
cord-269011-230p8rsf	381	7	1998	1998	CD
cord-269011-230p8rsf	381	8	)	)	-RRB-
cord-269011-230p8rsf	382	1	the	the	DT
cord-269011-230p8rsf	382	2	amino	amino	NN
cord-269011-230p8rsf	382	3	terminus	terminus	NN
cord-269011-230p8rsf	382	4	of	of	IN
cord-269011-230p8rsf	382	5	the	the	DT
cord-269011-230p8rsf	382	6	first	first	JJ
cord-269011-230p8rsf	382	7	HR	hr	NN
cord-269011-230p8rsf	382	8	region	region	NN
cord-269011-230p8rsf	382	9	.	.	.
cord-269011-230p8rsf	383	1	Binding	bind	VBG
cord-269011-230p8rsf	383	2	of	of	IN
cord-269011-230p8rsf	383	3	the	the	DT
cord-269011-230p8rsf	383	4	S1	s1	NN
cord-269011-230p8rsf	383	5	subunit	subunit	NN
cord-269011-230p8rsf	383	6	to	to	IN
cord-269011-230p8rsf	383	7	the	the	DT
cord-269011-230p8rsf	383	8	(	(	-LRB-
cord-269011-230p8rsf	383	9	soluble	soluble	JJ
cord-269011-230p8rsf	383	10	)	)	-RRB-
cord-269011-230p8rsf	383	11	receptor	receptor	NN
cord-269011-230p8rsf	383	12	,	,	,
cord-269011-230p8rsf	383	13	or	or	CC
cord-269011-230p8rsf	383	14	exposure	exposure	NN
cord-269011-230p8rsf	383	15	to	to	IN
cord-269011-230p8rsf	383	16	37	37	CD
cord-269011-230p8rsf	383	17	C	c	NN
cord-269011-230p8rsf	383	18	and	and	CC
cord-269011-230p8rsf	383	19	an	an	DT
cord-269011-230p8rsf	383	20	elevated	elevated	JJ
cord-269011-230p8rsf	383	21	pH	ph	NN
cord-269011-230p8rsf	383	22	,	,	,
cord-269011-230p8rsf	383	23	has	have	VBZ
cord-269011-230p8rsf	383	24	been	be	VBN
cord-269011-230p8rsf	383	25	shown	show	VBN
cord-269011-230p8rsf	383	26	to	to	TO
cord-269011-230p8rsf	383	27	trigger	trigger	VB
cord-269011-230p8rsf	383	28	conformational	conformational	JJ
cord-269011-230p8rsf	383	29	changes	change	NNS
cord-269011-230p8rsf	383	30	that	that	WDT
cord-269011-230p8rsf	383	31	are	be	VBP
cord-269011-230p8rsf	383	32	supposed	suppose	VBN
cord-269011-230p8rsf	383	33	to	to	TO
cord-269011-230p8rsf	383	34	facilitate	facilitate	VB
cord-269011-230p8rsf	383	35	virus	virus	NN
cord-269011-230p8rsf	383	36	entry	entry	NN
cord-269011-230p8rsf	383	37	by	by	IN
cord-269011-230p8rsf	383	38	activation	activation	NN
cord-269011-230p8rsf	383	39	of	of	IN
cord-269011-230p8rsf	383	40	the	the	DT
cord-269011-230p8rsf	383	41	fusion	fusion	NN
cord-269011-230p8rsf	383	42	function	function	NN
cord-269011-230p8rsf	383	43	of	of	IN
cord-269011-230p8rsf	383	44	the	the	DT
cord-269011-230p8rsf	383	45	S2	S2	NNP
cord-269011-230p8rsf	383	46	subunit	subunit	NN
cord-269011-230p8rsf	383	47	(	(	-LRB-
cord-269011-230p8rsf	383	48	Breslin	Breslin	NNP
cord-269011-230p8rsf	383	49	et	et	NNP
cord-269011-230p8rsf	383	50	al	al	NNP
cord-269011-230p8rsf	383	51	.	.	NNP
cord-269011-230p8rsf	383	52	,	,	,
cord-269011-230p8rsf	383	53	2003	2003	CD
cord-269011-230p8rsf	383	54	;	;	:
cord-269011-230p8rsf	383	55	Gallagher	Gallagher	NNP
cord-269011-230p8rsf	383	56	,	,	,
cord-269011-230p8rsf	383	57	1997	1997	CD
cord-269011-230p8rsf	383	58	;	;	:
cord-269011-230p8rsf	383	59	Lewicki	Lewicki	NNP
cord-269011-230p8rsf	383	60	and	and	CC
cord-269011-230p8rsf	383	61	Gallagher	Gallagher	NNP
cord-269011-230p8rsf	383	62	,	,	,
cord-269011-230p8rsf	383	63	2002	2002	CD
cord-269011-230p8rsf	383	64	;	;	:
cord-269011-230p8rsf	383	65	Matsuyama	Matsuyama	NNP
cord-269011-230p8rsf	383	66	and	and	CC
cord-269011-230p8rsf	383	67	Taguchi	Taguchi	NNP
cord-269011-230p8rsf	383	68	,	,	,
cord-269011-230p8rsf	383	69	2002	2002	CD
cord-269011-230p8rsf	383	70	;	;	:
cord-269011-230p8rsf	383	71	Miura	Miura	NNP
cord-269011-230p8rsf	383	72	et	et	NNP
cord-269011-230p8rsf	383	73	al	al	NNP
cord-269011-230p8rsf	383	74	.	.	NNP
cord-269011-230p8rsf	383	75	,	,	,
cord-269011-230p8rsf	383	76	2004	2004	CD
cord-269011-230p8rsf	383	77	;	;	:
cord-269011-230p8rsf	383	78	Sturman	Sturman	NNP
cord-269011-230p8rsf	383	79	et	et	NNP
cord-269011-230p8rsf	383	80	al	al	NNP
cord-269011-230p8rsf	383	81	.	.	NNP
cord-269011-230p8rsf	383	82	,	,	,
cord-269011-230p8rsf	383	83	1990	1990	CD
cord-269011-230p8rsf	383	84	;	;	:
cord-269011-230p8rsf	383	85	Taguchi	Taguchi	NNP
cord-269011-230p8rsf	383	86	and	and	CC
cord-269011-230p8rsf	383	87	Matsuyama	Matsuyama	NNP
cord-269011-230p8rsf	383	88	,	,	,
cord-269011-230p8rsf	383	89	2002	2002	CD
cord-269011-230p8rsf	383	90	;	;	:
cord-269011-230p8rsf	383	91	Zelus	Zelus	NNP
cord-269011-230p8rsf	383	92	et	et	FW
cord-269011-230p8rsf	383	93	al	al	NNP
cord-269011-230p8rsf	383	94	.	.	NNP
cord-269011-230p8rsf	383	95	,	,	,
cord-269011-230p8rsf	383	96	2003	2003	CD
cord-269011-230p8rsf	383	97	)	)	-RRB-
cord-269011-230p8rsf	383	98	.	.	.
cord-269011-230p8rsf	384	1	This	this	DT
cord-269011-230p8rsf	384	2	conformational	conformational	JJ
cord-269011-230p8rsf	384	3	change	change	NN
cord-269011-230p8rsf	384	4	is	be	VBZ
cord-269011-230p8rsf	384	5	thought	think	VBN
cord-269011-230p8rsf	384	6	to	to	TO
cord-269011-230p8rsf	384	7	lead	lead	VB
cord-269011-230p8rsf	384	8	to	to	IN
cord-269011-230p8rsf	384	9	exposure	exposure	NN
cord-269011-230p8rsf	384	10	of	of	IN
cord-269011-230p8rsf	384	11	the	the	DT
cord-269011-230p8rsf	384	12	fusion	fusion	NN
cord-269011-230p8rsf	384	13	peptide	peptide	NN
cord-269011-230p8rsf	384	14	and	and	CC
cord-269011-230p8rsf	384	15	its	-PRON-	PRP$
cord-269011-230p8rsf	384	16	interaction	interaction	NN
cord-269011-230p8rsf	384	17	with	with	IN
cord-269011-230p8rsf	384	18	the	the	DT
cord-269011-230p8rsf	384	19	target	target	NN
cord-269011-230p8rsf	384	20	membrane	membrane	NN
cord-269011-230p8rsf	384	21	,	,	,
cord-269011-230p8rsf	384	22	further	further	JJ
cord-269011-230p8rsf	384	23	changes	change	NNS
cord-269011-230p8rsf	384	24	resulting	result	VBG
cord-269011-230p8rsf	384	25	in	in	IN
cord-269011-230p8rsf	384	26	the	the	DT
cord-269011-230p8rsf	384	27	formation	formation	NN
cord-269011-230p8rsf	384	28	of	of	IN
cord-269011-230p8rsf	384	29	a	a	DT
cord-269011-230p8rsf	384	30	heterotrimeric	heterotrimeric	JJ
cord-269011-230p8rsf	384	31	six	six	CD
cord-269011-230p8rsf	384	32	-	-	HYPH
cord-269011-230p8rsf	384	33	helix	helix	NN
cord-269011-230p8rsf	384	34	bundle	bundle	NN
cord-269011-230p8rsf	384	35	,	,	,
cord-269011-230p8rsf	384	36	characteristic	characteristic	JJ
cord-269011-230p8rsf	384	37	of	of	IN
cord-269011-230p8rsf	384	38	class	class	NN
cord-269011-230p8rsf	384	39	I	-PRON-	PRP
cord-269011-230p8rsf	384	40	viral	viral	JJ
cord-269011-230p8rsf	384	41	fusion	fusion	NN
cord-269011-230p8rsf	384	42	proteins	protein	NNS
cord-269011-230p8rsf	384	43	,	,	,
cord-269011-230p8rsf	384	44	during	during	IN
cord-269011-230p8rsf	384	45	the	the	DT
cord-269011-230p8rsf	384	46	membrane	membrane	NN
cord-269011-230p8rsf	384	47	fusion	fusion	NN
cord-269011-230p8rsf	384	48	process	process	NN
cord-269011-230p8rsf	384	49	.	.	.
cord-269011-230p8rsf	385	1	Indeed	indeed	RB
cord-269011-230p8rsf	385	2	,	,	,
cord-269011-230p8rsf	385	3	peptides	peptide	NNS
cord-269011-230p8rsf	385	4	corresponding	correspond	VBG
cord-269011-230p8rsf	385	5	to	to	IN
cord-269011-230p8rsf	385	6	the	the	DT
cord-269011-230p8rsf	385	7	HR	hr	NN
cord-269011-230p8rsf	385	8	regions	region	NNS
cord-269011-230p8rsf	385	9	of	of	IN
cord-269011-230p8rsf	385	10	MHV	MHV	NNP
cord-269011-230p8rsf	386	1	(	(	-LRB-
cord-269011-230p8rsf	386	2	Bosch	Bosch	NNP
cord-269011-230p8rsf	386	3	et	et	NNP
cord-269011-230p8rsf	386	4	al	al	NNP
cord-269011-230p8rsf	386	5	.	.	NNP
cord-269011-230p8rsf	386	6	,	,	,
cord-269011-230p8rsf	386	7	2003	2003	CD
cord-269011-230p8rsf	387	1	;	;	:
cord-269011-230p8rsf	387	2	Xu	Xu	NNP
cord-269011-230p8rsf	387	3	et	et	NNP
cord-269011-230p8rsf	387	4	al	al	NNP
cord-269011-230p8rsf	387	5	.	.	NNP
cord-269011-230p8rsf	387	6	,	,	,
cord-269011-230p8rsf	387	7	2004	2004	CD
cord-269011-230p8rsf	387	8	)	)	-RRB-
cord-269011-230p8rsf	387	9	and	and	CC
cord-269011-230p8rsf	387	10	SARS	SARS	NNP
cord-269011-230p8rsf	387	11	-	-	HYPH
cord-269011-230p8rsf	387	12	CoV	CoV	NNP
cord-269011-230p8rsf	387	13	(	(	-LRB-
cord-269011-230p8rsf	387	14	Bosch	Bosch	NNP
cord-269011-230p8rsf	387	15	et	et	NNP
cord-269011-230p8rsf	387	16	al	al	NNP
cord-269011-230p8rsf	387	17	.	.	NNP
cord-269011-230p8rsf	387	18	,	,	,
cord-269011-230p8rsf	387	19	2004b	2004b	CD
cord-269011-230p8rsf	387	20	;	;	:
cord-269011-230p8rsf	387	21	Ingallinella	Ingallinella	NNP
cord-269011-230p8rsf	387	22	et	et	NNP
cord-269011-230p8rsf	387	23	al	al	NNP
cord-269011-230p8rsf	387	24	.	.	NNP
cord-269011-230p8rsf	387	25	,	,	,
cord-269011-230p8rsf	387	26	2004	2004	CD
cord-269011-230p8rsf	387	27	;	;	:
cord-269011-230p8rsf	387	28	Liu	Liu	NNP
cord-269011-230p8rsf	387	29	et	et	NNP
cord-269011-230p8rsf	387	30	al	al	NNP
cord-269011-230p8rsf	387	31	.	.	NNP
cord-269011-230p8rsf	387	32	,	,	,
cord-269011-230p8rsf	387	33	2004	2004	CD
cord-269011-230p8rsf	387	34	;	;	:
cord-269011-230p8rsf	387	35	Tripet	Tripet	NNP
cord-269011-230p8rsf	387	36	et	et	NNP
cord-269011-230p8rsf	387	37	al	al	NNP
cord-269011-230p8rsf	387	38	.	.	NNP
cord-269011-230p8rsf	387	39	,	,	,
cord-269011-230p8rsf	387	40	2004	2004	CD
cord-269011-230p8rsf	387	41	;	;	:
cord-269011-230p8rsf	387	42	Zhu	Zhu	NNP
cord-269011-230p8rsf	387	43	et	et	FW
cord-269011-230p8rsf	387	44	al	al	NNP
cord-269011-230p8rsf	387	45	.	.	NNP
cord-269011-230p8rsf	387	46	,	,	,
cord-269011-230p8rsf	387	47	2004	2004	CD
cord-269011-230p8rsf	387	48	)	)	-RRB-
cord-269011-230p8rsf	387	49	were	be	VBD
cord-269011-230p8rsf	387	50	found	find	VBN
cord-269011-230p8rsf	387	51	to	to	TO
cord-269011-230p8rsf	387	52	assemble	assemble	VB
cord-269011-230p8rsf	387	53	into	into	IN
cord-269011-230p8rsf	387	54	stable	stable	JJ
cord-269011-230p8rsf	387	55	oligomeric	oligomeric	JJ
cord-269011-230p8rsf	387	56	complexes	complex	NNS
cord-269011-230p8rsf	387	57	in	in	IN
cord-269011-230p8rsf	387	58	an	an	DT
cord-269011-230p8rsf	387	59	antiparallel	antiparallel	JJ
cord-269011-230p8rsf	387	60	manner	manner	NN
cord-269011-230p8rsf	387	61	,	,	,
cord-269011-230p8rsf	387	62	which	which	WDT
cord-269011-230p8rsf	387	63	in	in	IN
cord-269011-230p8rsf	387	64	the	the	DT
cord-269011-230p8rsf	387	65	natural	natural	JJ
cord-269011-230p8rsf	387	66	situation	situation	NN
cord-269011-230p8rsf	387	67	would	would	MD
cord-269011-230p8rsf	387	68	result	result	VB
cord-269011-230p8rsf	387	69	in	in	IN
cord-269011-230p8rsf	387	70	the	the	DT
cord-269011-230p8rsf	387	71	close	close	JJ
cord-269011-230p8rsf	387	72	colocation	colocation	NN
cord-269011-230p8rsf	387	73	of	of	IN
cord-269011-230p8rsf	387	74	the	the	DT
cord-269011-230p8rsf	387	75	fusion	fusion	NN
cord-269011-230p8rsf	387	76	peptide	peptide	NN
cord-269011-230p8rsf	387	77	and	and	CC
cord-269011-230p8rsf	387	78	the	the	DT
cord-269011-230p8rsf	387	79	transmembrane	transmembrane	NN
cord-269011-230p8rsf	387	80	domain	domain	NN
cord-269011-230p8rsf	387	81	.	.	.
cord-269011-230p8rsf	388	1	These	these	DT
cord-269011-230p8rsf	388	2	peptides	peptide	NNS
cord-269011-230p8rsf	388	3	were	be	VBD
cord-269011-230p8rsf	388	4	further	further	RB
cord-269011-230p8rsf	388	5	shown	show	VBN
cord-269011-230p8rsf	388	6	to	to	TO
cord-269011-230p8rsf	388	7	be	be	VB
cord-269011-230p8rsf	388	8	inhibitors	inhibitor	NNS
cord-269011-230p8rsf	388	9	for	for	IN
cord-269011-230p8rsf	388	10	viral	viral	JJ
cord-269011-230p8rsf	388	11	entry	entry	NN
cord-269011-230p8rsf	389	1	(	(	-LRB-
cord-269011-230p8rsf	389	2	Bosch	Bosch	NNP
cord-269011-230p8rsf	389	3	et	et	NNP
cord-269011-230p8rsf	389	4	al	al	NNP
cord-269011-230p8rsf	389	5	.	.	.
cord-269011-230p8rsf	390	1	,	,	,
cord-269011-230p8rsf	390	2	2003	2003	CD
cord-269011-230p8rsf	391	1	(	(	-LRB-
cord-269011-230p8rsf	391	2	Bosch	Bosch	NNP
cord-269011-230p8rsf	391	3	et	et	NNP
cord-269011-230p8rsf	391	4	al	al	NNP
cord-269011-230p8rsf	391	5	.	.	.
cord-269011-230p8rsf	392	1	,	,	,
cord-269011-230p8rsf	392	2	,	,	,
cord-269011-230p8rsf	392	3	2004b	2004b	CD
cord-269011-230p8rsf	392	4	Liu	Liu	NNP
cord-269011-230p8rsf	392	5	et	et	NNP
cord-269011-230p8rsf	392	6	al	al	NNP
cord-269011-230p8rsf	392	7	.	.	NNP
cord-269011-230p8rsf	392	8	,	,	,
cord-269011-230p8rsf	392	9	2004	2004	CD
cord-269011-230p8rsf	393	1	;	;	:
cord-269011-230p8rsf	393	2	Yuan	Yuan	NNP
cord-269011-230p8rsf	393	3	et	et	FW
cord-269011-230p8rsf	393	4	al	al	NNP
cord-269011-230p8rsf	393	5	.	.	NNP
cord-269011-230p8rsf	393	6	,	,	,
cord-269011-230p8rsf	393	7	2004	2004	CD
cord-269011-230p8rsf	393	8	;	;	:
cord-269011-230p8rsf	393	9	Zhu	Zhu	NNP
cord-269011-230p8rsf	393	10	et	et	FW
cord-269011-230p8rsf	393	11	al	al	NNP
cord-269011-230p8rsf	393	12	.	.	NNP
cord-269011-230p8rsf	393	13	,	,	,
cord-269011-230p8rsf	393	14	2004	2004	CD
cord-269011-230p8rsf	393	15	)	)	-RRB-
cord-269011-230p8rsf	393	16	.	.	.
cord-269011-230p8rsf	394	1	Besides	besides	IN
cord-269011-230p8rsf	394	2	the	the	DT
cord-269011-230p8rsf	394	3	HR	hr	NN
cord-269011-230p8rsf	394	4	regions	region	NNS
cord-269011-230p8rsf	394	5	,	,	,
cord-269011-230p8rsf	394	6	other	other	JJ
cord-269011-230p8rsf	394	7	parts	part	NNS
cord-269011-230p8rsf	394	8	of	of	IN
cord-269011-230p8rsf	394	9	the	the	DT
cord-269011-230p8rsf	394	10	S	S	NNP
cord-269011-230p8rsf	394	11	protein	protein	NN
cord-269011-230p8rsf	394	12	are	be	VBP
cord-269011-230p8rsf	394	13	also	also	RB
cord-269011-230p8rsf	394	14	likely	likely	JJ
cord-269011-230p8rsf	394	15	to	to	TO
cord-269011-230p8rsf	394	16	be	be	VB
cord-269011-230p8rsf	394	17	important	important	JJ
cord-269011-230p8rsf	394	18	for	for	IN
cord-269011-230p8rsf	394	19	the	the	DT
cord-269011-230p8rsf	394	20	fusion	fusion	NN
cord-269011-230p8rsf	394	21	process	process	NN
cord-269011-230p8rsf	394	22	.	.	.
cord-269011-230p8rsf	395	1	All	all	DT
cord-269011-230p8rsf	395	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	395	3	S	s	NN
cord-269011-230p8rsf	395	4	proteins	protein	NNS
cord-269011-230p8rsf	395	5	contain	contain	VBP
cord-269011-230p8rsf	395	6	a	a	DT
cord-269011-230p8rsf	395	7	highly	highly	RB
cord-269011-230p8rsf	395	8	conserved	conserve	VBN
cord-269011-230p8rsf	395	9	region	region	NN
cord-269011-230p8rsf	395	10	(	(	-LRB-
cord-269011-230p8rsf	395	11	de	de	FW
cord-269011-230p8rsf	395	12	Groot	Groot	NNP
cord-269011-230p8rsf	395	13	et	et	FW
cord-269011-230p8rsf	395	14	al	al	NNP
cord-269011-230p8rsf	395	15	.	.	NNP
cord-269011-230p8rsf	395	16	,	,	,
cord-269011-230p8rsf	395	17	1987a	1987a	CD
cord-269011-230p8rsf	395	18	)	)	-RRB-
cord-269011-230p8rsf	395	19	,	,	,
cord-269011-230p8rsf	395	20	rich	rich	JJ
cord-269011-230p8rsf	395	21	in	in	IN
cord-269011-230p8rsf	395	22	aromatic	aromatic	JJ
cord-269011-230p8rsf	395	23	residues	residue	NNS
cord-269011-230p8rsf	395	24	,	,	,
cord-269011-230p8rsf	395	25	downstream	downstream	RB
cord-269011-230p8rsf	395	26	of	of	IN
cord-269011-230p8rsf	395	27	the	the	DT
cord-269011-230p8rsf	395	28	second	second	JJ
cord-269011-230p8rsf	395	29	HR	hr	NN
cord-269011-230p8rsf	395	30	region	region	NN
cord-269011-230p8rsf	395	31	,	,	,
cord-269011-230p8rsf	395	32	part	part	NN
cord-269011-230p8rsf	395	33	of	of	IN
cord-269011-230p8rsf	395	34	which	which	WDT
cord-269011-230p8rsf	395	35	may	may	MD
cord-269011-230p8rsf	395	36	form	form	VB
cord-269011-230p8rsf	395	37	the	the	DT
cord-269011-230p8rsf	395	38	start	start	NN
cord-269011-230p8rsf	395	39	of	of	IN
cord-269011-230p8rsf	395	40	the	the	DT
cord-269011-230p8rsf	395	41	transmembrane	transmembrane	NN
cord-269011-230p8rsf	395	42	domain	domain	NN
cord-269011-230p8rsf	395	43	.	.	.
cord-269011-230p8rsf	396	1	The	the	DT
cord-269011-230p8rsf	396	2	function	function	NN
cord-269011-230p8rsf	396	3	of	of	IN
cord-269011-230p8rsf	396	4	this	this	DT
cord-269011-230p8rsf	396	5	domain	domain	NN
cord-269011-230p8rsf	396	6	is	be	VBZ
cord-269011-230p8rsf	396	7	unknown	unknown	JJ
cord-269011-230p8rsf	396	8	,	,	,
cord-269011-230p8rsf	396	9	but	but	CC
cord-269011-230p8rsf	396	10	a	a	DT
cord-269011-230p8rsf	396	11	similar	similar	JJ
cord-269011-230p8rsf	396	12	region	region	NN
cord-269011-230p8rsf	396	13	in	in	IN
cord-269011-230p8rsf	396	14	the	the	DT
cord-269011-230p8rsf	396	15	HIV-1	HIV-1	NNP
cord-269011-230p8rsf	396	16	Env	Env	NNP
cord-269011-230p8rsf	396	17	protein	protein	NN
cord-269011-230p8rsf	396	18	was	be	VBD
cord-269011-230p8rsf	396	19	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	396	20	to	to	TO
cord-269011-230p8rsf	396	21	be	be	VB
cord-269011-230p8rsf	396	22	important	important	JJ
cord-269011-230p8rsf	396	23	for	for	IN
cord-269011-230p8rsf	396	24	viral	viral	JJ
cord-269011-230p8rsf	396	25	fusion	fusion	NN
cord-269011-230p8rsf	396	26	and	and	CC
cord-269011-230p8rsf	396	27	Env	env	NN
cord-269011-230p8rsf	396	28	incorporation	incorporation	NN
cord-269011-230p8rsf	396	29	into	into	IN
cord-269011-230p8rsf	396	30	virions	virion	NNS
cord-269011-230p8rsf	396	31	(	(	-LRB-
cord-269011-230p8rsf	396	32	Salzwedel	Salzwedel	NNP
cord-269011-230p8rsf	396	33	et	et	NNP
cord-269011-230p8rsf	396	34	al	al	NNP
cord-269011-230p8rsf	396	35	.	.	NNP
cord-269011-230p8rsf	396	36	,	,	,
cord-269011-230p8rsf	396	37	1999	1999	CD
cord-269011-230p8rsf	396	38	)	)	-RRB-
cord-269011-230p8rsf	396	39	.	.	.
cord-269011-230p8rsf	397	1	Immediately	immediately	RB
cord-269011-230p8rsf	397	2	downstream	downstream	RB
cord-269011-230p8rsf	397	3	of	of	IN
cord-269011-230p8rsf	397	4	the	the	DT
cord-269011-230p8rsf	397	5	transmembrane	transmembrane	NN
cord-269011-230p8rsf	397	6	domain	domain	NN
cord-269011-230p8rsf	397	7	all	all	DT
cord-269011-230p8rsf	397	8	S	s	NN
cord-269011-230p8rsf	397	9	proteins	protein	NNS
cord-269011-230p8rsf	397	10	contain	contain	VBP
cord-269011-230p8rsf	397	11	a	a	DT
cord-269011-230p8rsf	397	12	cysteine	cysteine	NN
cord-269011-230p8rsf	397	13	-	-	HYPH
cord-269011-230p8rsf	397	14	rich	rich	JJ
cord-269011-230p8rsf	397	15	region	region	NN
cord-269011-230p8rsf	397	16	(	(	-LRB-
cord-269011-230p8rsf	397	17	de	de	FW
cord-269011-230p8rsf	397	18	Groot	Groot	NNP
cord-269011-230p8rsf	397	19	et	et	FW
cord-269011-230p8rsf	397	20	al	al	NNP
cord-269011-230p8rsf	397	21	.	.	NNP
cord-269011-230p8rsf	397	22	,	,	,
cord-269011-230p8rsf	397	23	1987a	1987a	CD
cord-269011-230p8rsf	397	24	)	)	-RRB-
cord-269011-230p8rsf	397	25	.	.	.
cord-269011-230p8rsf	398	1	Using	use	VBG
cord-269011-230p8rsf	398	2	a	a	DT
cord-269011-230p8rsf	398	3	mutational	mutational	JJ
cord-269011-230p8rsf	398	4	approach	approach	NN
cord-269011-230p8rsf	398	5	including	include	VBG
cord-269011-230p8rsf	398	6	deletions	deletion	NNS
cord-269011-230p8rsf	398	7	,	,	,
cord-269011-230p8rsf	398	8	insertions	insertion	NNS
cord-269011-230p8rsf	398	9	,	,	,
cord-269011-230p8rsf	398	10	and	and	CC
cord-269011-230p8rsf	398	11	substitutions	substitution	NNS
cord-269011-230p8rsf	398	12	,	,	,
cord-269011-230p8rsf	398	13	both	both	CC
cord-269011-230p8rsf	398	14	the	the	DT
cord-269011-230p8rsf	398	15	transmembrane	transmembrane	NN
cord-269011-230p8rsf	398	16	domain	domain	NN
cord-269011-230p8rsf	398	17	and	and	CC
cord-269011-230p8rsf	398	18	the	the	DT
cord-269011-230p8rsf	398	19	cysteine	cysteine	NN
cord-269011-230p8rsf	398	20	-	-	HYPH
cord-269011-230p8rsf	398	21	rich	rich	JJ
cord-269011-230p8rsf	398	22	region	region	NN
cord-269011-230p8rsf	398	23	immediately	immediately	RB
cord-269011-230p8rsf	398	24	downstream	downstream	VBP
cord-269011-230p8rsf	398	25	thereof	thereof	RB
cord-269011-230p8rsf	398	26	,	,	,
cord-269011-230p8rsf	398	27	but	but	CC
cord-269011-230p8rsf	398	28	not	not	RB
cord-269011-230p8rsf	398	29	the	the	DT
cord-269011-230p8rsf	398	30	carboxy	carboxy	JJ
cord-269011-230p8rsf	398	31	-	-	HYPH
cord-269011-230p8rsf	398	32	terminal	terminal	NN
cord-269011-230p8rsf	398	33	part	part	NN
cord-269011-230p8rsf	398	34	of	of	IN
cord-269011-230p8rsf	398	35	the	the	DT
cord-269011-230p8rsf	398	36	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	398	37	tail	tail	NN
cord-269011-230p8rsf	398	38	,	,	,
cord-269011-230p8rsf	398	39	were	be	VBD
cord-269011-230p8rsf	398	40	shown	show	VBN
cord-269011-230p8rsf	398	41	to	to	TO
cord-269011-230p8rsf	398	42	be	be	VB
cord-269011-230p8rsf	398	43	important	important	JJ
cord-269011-230p8rsf	398	44	for	for	IN
cord-269011-230p8rsf	398	45	MHV	MHV	NNP
cord-269011-230p8rsf	398	46	S	S	NNP
cord-269011-230p8rsf	398	47	protein	protein	NN
cord-269011-230p8rsf	398	48	-	-	HYPH
cord-269011-230p8rsf	398	49	induced	induce	VBN
cord-269011-230p8rsf	398	50	cell	cell	NN
cord-269011-230p8rsf	398	51	-	-	HYPH
cord-269011-230p8rsf	398	52	cell	cell	NN
cord-269011-230p8rsf	398	53	fusion	fusion	NN
cord-269011-230p8rsf	399	1	(	(	-LRB-
cord-269011-230p8rsf	399	2	Bos	Bos	NNP
cord-269011-230p8rsf	399	3	et	et	NNP
cord-269011-230p8rsf	399	4	al	al	NNP
cord-269011-230p8rsf	399	5	.	.	.
cord-269011-230p8rsf	400	1	,	,	,
cord-269011-230p8rsf	400	2	1995	1995	CD
cord-269011-230p8rsf	400	3	;	;	:
cord-269011-230p8rsf	400	4	Chang	Chang	NNP
cord-269011-230p8rsf	400	5	and	and	CC
cord-269011-230p8rsf	400	6	Gombold	Gombold	NNP
cord-269011-230p8rsf	400	7	,	,	,
cord-269011-230p8rsf	400	8	2001	2001	CD
cord-269011-230p8rsf	400	9	;	;	:
cord-269011-230p8rsf	400	10	Chang	Chang	NNP
cord-269011-230p8rsf	400	11	et	et	NNP
cord-269011-230p8rsf	400	12	al	al	NNP
cord-269011-230p8rsf	400	13	.	.	NNP
cord-269011-230p8rsf	400	14	,	,	,
cord-269011-230p8rsf	400	15	2000	2000	CD
cord-269011-230p8rsf	400	16	)	)	-RRB-
cord-269011-230p8rsf	401	1	The	the	DT
cord-269011-230p8rsf	401	2	cleavage	cleavage	NN
cord-269011-230p8rsf	401	3	requirements	requirement	NNS
cord-269011-230p8rsf	401	4	of	of	IN
cord-269011-230p8rsf	401	5	the	the	DT
cord-269011-230p8rsf	401	6	S	S	NNP
cord-269011-230p8rsf	401	7	proteins	protein	NNS
cord-269011-230p8rsf	401	8	for	for	IN
cord-269011-230p8rsf	401	9	the	the	DT
cord-269011-230p8rsf	401	10	biological	biological	JJ
cord-269011-230p8rsf	401	11	activities	activity	NNS
cord-269011-230p8rsf	401	12	of	of	IN
cord-269011-230p8rsf	401	13	the	the	DT
cord-269011-230p8rsf	401	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	401	15	spike	spike	NN
cord-269011-230p8rsf	401	16	remain	remain	VBP
cord-269011-230p8rsf	401	17	enigmatic	enigmatic	JJ
cord-269011-230p8rsf	401	18	.	.	.
cord-269011-230p8rsf	402	1	Whereas	whereas	IN
cord-269011-230p8rsf	402	2	the	the	DT
cord-269011-230p8rsf	402	3	S	S	NNP
cord-269011-230p8rsf	402	4	proteins	protein	NNS
cord-269011-230p8rsf	402	5	of	of	IN
cord-269011-230p8rsf	402	6	group	group	NN
cord-269011-230p8rsf	402	7	1	1	CD
cord-269011-230p8rsf	402	8	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	402	9	,	,	,
cord-269011-230p8rsf	402	10	such	such	JJ
cord-269011-230p8rsf	402	11	as	as	IN
cord-269011-230p8rsf	402	12	FIPV	FIPV	NNS
cord-269011-230p8rsf	402	13	(	(	-LRB-
cord-269011-230p8rsf	402	14	Vennema	Vennema	NNP
cord-269011-230p8rsf	402	15	et	et	FW
cord-269011-230p8rsf	402	16	al	al	NNP
cord-269011-230p8rsf	402	17	.	.	NNP
cord-269011-230p8rsf	402	18	,	,	,
cord-269011-230p8rsf	402	19	1990a	1990a	CD
cord-269011-230p8rsf	402	20	)	)	-RRB-
cord-269011-230p8rsf	402	21	,	,	,
cord-269011-230p8rsf	402	22	are	be	VBP
cord-269011-230p8rsf	402	23	not	not	RB
cord-269011-230p8rsf	402	24	cleaved	cleave	VBN
cord-269011-230p8rsf	402	25	,	,	,
cord-269011-230p8rsf	402	26	those	those	DT
cord-269011-230p8rsf	402	27	of	of	IN
cord-269011-230p8rsf	402	28	other	other	JJ
cord-269011-230p8rsf	402	29	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	402	30	,	,	,
cord-269011-230p8rsf	402	31	particularly	particularly	RB
cord-269011-230p8rsf	402	32	of	of	IN
cord-269011-230p8rsf	402	33	groups	group	NNS
cord-269011-230p8rsf	402	34	2	2	CD
cord-269011-230p8rsf	402	35	and	and	CC
cord-269011-230p8rsf	402	36	3	3	CD
cord-269011-230p8rsf	402	37	,	,	,
cord-269011-230p8rsf	402	38	are	be	VBP
cord-269011-230p8rsf	402	39	cleaved	cleave	VBN
cord-269011-230p8rsf	402	40	to	to	IN
cord-269011-230p8rsf	402	41	variable	variable	JJ
cord-269011-230p8rsf	402	42	extents	extent	NNS
cord-269011-230p8rsf	402	43	,	,	,
cord-269011-230p8rsf	402	44	depending	depend	VBG
cord-269011-230p8rsf	402	45	on	on	IN
cord-269011-230p8rsf	402	46	the	the	DT
cord-269011-230p8rsf	402	47	viral	viral	JJ
cord-269011-230p8rsf	402	48	strain	strain	NN
cord-269011-230p8rsf	402	49	and	and	CC
cord-269011-230p8rsf	402	50	the	the	DT
cord-269011-230p8rsf	402	51	cell	cell	NN
cord-269011-230p8rsf	402	52	type	type	NN
cord-269011-230p8rsf	402	53	in	in	IN
cord-269011-230p8rsf	402	54	which	which	WDT
cord-269011-230p8rsf	402	55	the	the	DT
cord-269011-230p8rsf	402	56	viruses	virus	NNS
cord-269011-230p8rsf	402	57	are	be	VBP
cord-269011-230p8rsf	402	58	grown	grow	VBN
cord-269011-230p8rsf	402	59	(	(	-LRB-
cord-269011-230p8rsf	402	60	Frana	Frana	NNP
cord-269011-230p8rsf	402	61	et	et	FW
cord-269011-230p8rsf	402	62	al	al	NNP
cord-269011-230p8rsf	402	63	.	.	NNP
cord-269011-230p8rsf	402	64	,	,	,
cord-269011-230p8rsf	402	65	1985	1985	CD
cord-269011-230p8rsf	402	66	;	;	:
cord-269011-230p8rsf	402	67	reviewed	review	VBN
cord-269011-230p8rsf	402	68	by	by	IN
cord-269011-230p8rsf	402	69	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	402	70	,	,	,
cord-269011-230p8rsf	402	71	1995	1995	CD
cord-269011-230p8rsf	402	72	)	)	-RRB-
cord-269011-230p8rsf	402	73	.	.	.
cord-269011-230p8rsf	403	1	Cleavage	cleavage	NN
cord-269011-230p8rsf	403	2	of	of	IN
cord-269011-230p8rsf	403	3	the	the	DT
cord-269011-230p8rsf	403	4	S	S	NNP
cord-269011-230p8rsf	403	5	proteins	protein	NNS
cord-269011-230p8rsf	403	6	is	be	VBZ
cord-269011-230p8rsf	403	7	not	not	RB
cord-269011-230p8rsf	403	8	required	require	VBN
cord-269011-230p8rsf	403	9	to	to	TO
cord-269011-230p8rsf	403	10	expose	expose	VB
cord-269011-230p8rsf	403	11	the	the	DT
cord-269011-230p8rsf	403	12	internal	internal	JJ
cord-269011-230p8rsf	403	13	fusion	fusion	NN
cord-269011-230p8rsf	403	14	peptide	peptide	NN
cord-269011-230p8rsf	403	15	.	.	.
cord-269011-230p8rsf	404	1	Whereas	whereas	IN
cord-269011-230p8rsf	404	2	cleavage	cleavage	NN
cord-269011-230p8rsf	404	3	of	of	IN
cord-269011-230p8rsf	404	4	the	the	DT
cord-269011-230p8rsf	404	5	MHV	MHV	NNP
cord-269011-230p8rsf	404	6	S	S	NNP
cord-269011-230p8rsf	404	7	protein	protein	NN
cord-269011-230p8rsf	404	8	generally	generally	RB
cord-269011-230p8rsf	404	9	correlates	correlate	VBZ
cord-269011-230p8rsf	404	10	strongly	strongly	RB
cord-269011-230p8rsf	404	11	with	with	IN
cord-269011-230p8rsf	404	12	cell	cell	NN
cord-269011-230p8rsf	404	13	-	-	HYPH
cord-269011-230p8rsf	404	14	cell	cell	NN
cord-269011-230p8rsf	404	15	fusion	fusion	NN
cord-269011-230p8rsf	404	16	(	(	-LRB-
cord-269011-230p8rsf	404	17	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	404	18	,	,	,
cord-269011-230p8rsf	404	19	1995	1995	CD
cord-269011-230p8rsf	404	20	)	)	-RRB-
cord-269011-230p8rsf	404	21	,	,	,
cord-269011-230p8rsf	404	22	virus	virus	NN
cord-269011-230p8rsf	404	23	-	-	HYPH
cord-269011-230p8rsf	404	24	cell	cell	NN
cord-269011-230p8rsf	404	25	fusion	fusion	NN
cord-269011-230p8rsf	404	26	appeared	appear	VBD
cord-269011-230p8rsf	404	27	not	not	RB
cord-269011-230p8rsf	404	28	to	to	TO
cord-269011-230p8rsf	404	29	be	be	VB
cord-269011-230p8rsf	404	30	affected	affect	VBN
cord-269011-230p8rsf	404	31	by	by	IN
cord-269011-230p8rsf	404	32	preventing	prevent	VBG
cord-269011-230p8rsf	404	33	S	s	NN
cord-269011-230p8rsf	404	34	protein	protein	NN
cord-269011-230p8rsf	404	35	cleavage	cleavage	NN
cord-269011-230p8rsf	404	36	,	,	,
cord-269011-230p8rsf	404	37	indicating	indicate	VBG
cord-269011-230p8rsf	404	38	that	that	IN
cord-269011-230p8rsf	404	39	these	these	DT
cord-269011-230p8rsf	404	40	fusion	fusion	NN
cord-269011-230p8rsf	404	41	events	event	NNS
cord-269011-230p8rsf	404	42	have	have	VBP
cord-269011-230p8rsf	404	43	different	different	JJ
cord-269011-230p8rsf	404	44	requirements	requirement	NNS
cord-269011-230p8rsf	404	45	(	(	-LRB-
cord-269011-230p8rsf	404	46	de	de	FW
cord-269011-230p8rsf	404	47	Haan	Haan	NNP
cord-269011-230p8rsf	404	48	et	et	FW
cord-269011-230p8rsf	404	49	al	al	NNP
cord-269011-230p8rsf	404	50	.	.	NNP
cord-269011-230p8rsf	404	51	,	,	,
cord-269011-230p8rsf	404	52	2004	2004	CD
cord-269011-230p8rsf	404	53	)	)	-RRB-
cord-269011-230p8rsf	404	54	.	.	.
cord-269011-230p8rsf	405	1	Similarly	similarly	RB
cord-269011-230p8rsf	405	2	,	,	,
cord-269011-230p8rsf	405	3	whereas	whereas	IN
cord-269011-230p8rsf	405	4	trypsin	trypsin	NN
cord-269011-230p8rsf	405	5	activation	activation	NN
cord-269011-230p8rsf	405	6	of	of	IN
cord-269011-230p8rsf	405	7	SARS	SARS	NNP
cord-269011-230p8rsf	405	8	-	-	HYPH
cord-269011-230p8rsf	405	9	CoV	CoV	NNP
cord-269011-230p8rsf	405	10	S	S	NNP
cord-269011-230p8rsf	405	11	protein	protein	NN
cord-269011-230p8rsf	405	12	was	be	VBD
cord-269011-230p8rsf	405	13	required	require	VBN
cord-269011-230p8rsf	405	14	for	for	IN
cord-269011-230p8rsf	405	15	cell	cell	NN
cord-269011-230p8rsf	405	16	-	-	HYPH
cord-269011-230p8rsf	405	17	cell	cell	NN
cord-269011-230p8rsf	405	18	fusion	fusion	NN
cord-269011-230p8rsf	405	19	,	,	,
cord-269011-230p8rsf	405	20	it	-PRON-	PRP
cord-269011-230p8rsf	405	21	did	do	VBD
cord-269011-230p8rsf	405	22	not	not	RB
cord-269011-230p8rsf	405	23	enhance	enhance	VB
cord-269011-230p8rsf	405	24	the	the	DT
cord-269011-230p8rsf	405	25	infectivity	infectivity	NN
cord-269011-230p8rsf	405	26	of	of	IN
cord-269011-230p8rsf	405	27	cell	cell	NN
cord-269011-230p8rsf	405	28	-	-	HYPH
cord-269011-230p8rsf	405	29	free	free	JJ
cord-269011-230p8rsf	405	30	pseudovirions	pseudovirion	NNS
cord-269011-230p8rsf	405	31	(	(	-LRB-
cord-269011-230p8rsf	405	32	Simmons	Simmons	NNP
cord-269011-230p8rsf	405	33	et	et	NNP
cord-269011-230p8rsf	405	34	al	al	NNP
cord-269011-230p8rsf	405	35	.	.	NNP
cord-269011-230p8rsf	405	36	,	,	,
cord-269011-230p8rsf	405	37	2004	2004	CD
cord-269011-230p8rsf	405	38	)	)	-RRB-
cord-269011-230p8rsf	405	39	.	.	.
cord-269011-230p8rsf	406	1	For	for	IN
cord-269011-230p8rsf	406	2	MHV-4	MHV-4	NNP
cord-269011-230p8rsf	406	3	,	,	,
cord-269011-230p8rsf	406	4	the	the	DT
cord-269011-230p8rsf	406	5	spikes	spike	NNS
cord-269011-230p8rsf	406	6	of	of	IN
cord-269011-230p8rsf	406	7	which	which	WDT
cord-269011-230p8rsf	406	8	are	be	VBP
cord-269011-230p8rsf	406	9	able	able	JJ
cord-269011-230p8rsf	406	10	to	to	TO
cord-269011-230p8rsf	406	11	initiate	initiate	VB
cord-269011-230p8rsf	406	12	fusion	fusion	NN
cord-269011-230p8rsf	406	13	without	without	IN
cord-269011-230p8rsf	406	14	prior	prior	JJ
cord-269011-230p8rsf	406	15	interaction	interaction	NN
cord-269011-230p8rsf	406	16	with	with	IN
cord-269011-230p8rsf	406	17	the	the	DT
cord-269011-230p8rsf	406	18	primary	primary	JJ
cord-269011-230p8rsf	406	19	MHV	MHV	NNP
cord-269011-230p8rsf	406	20	receptor	receptor	NN
cord-269011-230p8rsf	406	21	(	(	-LRB-
cord-269011-230p8rsf	406	22	Gallagher	Gallagher	NNP
cord-269011-230p8rsf	406	23	et	et	NNP
cord-269011-230p8rsf	406	24	al	al	NNP
cord-269011-230p8rsf	406	25	.	.	NNP
cord-269011-230p8rsf	406	26	,	,	,
cord-269011-230p8rsf	406	27	1992	1992	CD
cord-269011-230p8rsf	406	28	)	)	-RRB-
cord-269011-230p8rsf	406	29	,	,	,
cord-269011-230p8rsf	406	30	the	the	DT
cord-269011-230p8rsf	406	31	stability	stability	NN
cord-269011-230p8rsf	406	32	of	of	IN
cord-269011-230p8rsf	406	33	the	the	DT
cord-269011-230p8rsf	406	34	S1-S2	S1-S2	NNP
cord-269011-230p8rsf	406	35	heterodimers	heterodimer	NNS
cord-269011-230p8rsf	406	36	after	after	IN
cord-269011-230p8rsf	406	37	S	s	NN
cord-269011-230p8rsf	406	38	protein	protein	NN
cord-269011-230p8rsf	406	39	cleavage	cleavage	NN
cord-269011-230p8rsf	406	40	is	be	VBZ
cord-269011-230p8rsf	406	41	low	low	JJ
cord-269011-230p8rsf	406	42	,	,	,
cord-269011-230p8rsf	406	43	allowing	allow	VBG
cord-269011-230p8rsf	406	44	receptor	receptor	NN
cord-269011-230p8rsf	406	45	-	-	HYPH
cord-269011-230p8rsf	406	46	independent	independent	JJ
cord-269011-230p8rsf	406	47	fusion	fusion	NN
cord-269011-230p8rsf	406	48	.	.	.
cord-269011-230p8rsf	407	1	During	during	IN
cord-269011-230p8rsf	407	2	cell	cell	NN
cord-269011-230p8rsf	407	3	culture	culture	NN
cord-269011-230p8rsf	407	4	adaptation	adaptation	NN
cord-269011-230p8rsf	407	5	,	,	,
cord-269011-230p8rsf	407	6	however	however	RB
cord-269011-230p8rsf	407	7	,	,	,
cord-269011-230p8rsf	407	8	selected	select	VBN
cord-269011-230p8rsf	407	9	mutant	mutant	JJ
cord-269011-230p8rsf	407	10	viruses	virus	NNS
cord-269011-230p8rsf	407	11	carried	carry	VBD
cord-269011-230p8rsf	407	12	deletions	deletion	NNS
cord-269011-230p8rsf	407	13	in	in	IN
cord-269011-230p8rsf	407	14	the	the	DT
cord-269011-230p8rsf	407	15	S1	S1	NNP
cord-269011-230p8rsf	407	16	subunit	subunit	NN
cord-269011-230p8rsf	407	17	,	,	,
cord-269011-230p8rsf	407	18	downstream	downstream	RB
cord-269011-230p8rsf	407	19	of	of	IN
cord-269011-230p8rsf	407	20	the	the	DT
cord-269011-230p8rsf	407	21	receptor	receptor	NN
cord-269011-230p8rsf	407	22	-	-	HYPH
cord-269011-230p8rsf	407	23	binding	bind	VBG
cord-269011-230p8rsf	407	24	domain	domain	NN
cord-269011-230p8rsf	407	25	,	,	,
cord-269011-230p8rsf	407	26	which	which	WDT
cord-269011-230p8rsf	407	27	resulted	result	VBD
cord-269011-230p8rsf	407	28	in	in	IN
cord-269011-230p8rsf	407	29	stabilized	stabilize	VBN
cord-269011-230p8rsf	407	30	S1-S2	S1-S2	NNP
cord-269011-230p8rsf	407	31	heterodimers	heterodimer	NNS
cord-269011-230p8rsf	407	32	and	and	CC
cord-269011-230p8rsf	407	33	receptor	receptor	NN
cord-269011-230p8rsf	407	34	-	-	HYPH
cord-269011-230p8rsf	407	35	dependent	dependent	JJ
cord-269011-230p8rsf	407	36	fusion	fusion	NN
cord-269011-230p8rsf	407	37	activity	activity	NN
cord-269011-230p8rsf	408	1	(	(	-LRB-
cord-269011-230p8rsf	408	2	Krueger	Krueger	NNP
cord-269011-230p8rsf	408	3	et	et	NNP
cord-269011-230p8rsf	408	4	al	al	NNP
cord-269011-230p8rsf	408	5	.	.	NNP
cord-269011-230p8rsf	408	6	,	,	,
cord-269011-230p8rsf	408	7	2001	2001	CD
cord-269011-230p8rsf	408	8	)	)	-RRB-
cord-269011-230p8rsf	408	9	.	.	.
cord-269011-230p8rsf	409	1	Virions	Virions	NNP
cord-269011-230p8rsf	409	2	of	of	IN
cord-269011-230p8rsf	409	3	group	group	NN
cord-269011-230p8rsf	409	4	2	2	CD
cord-269011-230p8rsf	409	5	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	409	6	generally	generally	RB
cord-269011-230p8rsf	409	7	contain	contain	VBP
cord-269011-230p8rsf	409	8	a	a	DT
cord-269011-230p8rsf	409	9	fringe	fringe	NN
cord-269011-230p8rsf	409	10	of	of	IN
cord-269011-230p8rsf	409	11	shorter	short	JJR
cord-269011-230p8rsf	409	12	surface	surface	NN
cord-269011-230p8rsf	409	13	projections	projection	NNS
cord-269011-230p8rsf	409	14	in	in	IN
cord-269011-230p8rsf	409	15	addition	addition	NN
cord-269011-230p8rsf	409	16	to	to	IN
cord-269011-230p8rsf	409	17	the	the	DT
cord-269011-230p8rsf	409	18	characteristic	characteristic	JJ
cord-269011-230p8rsf	409	19	spikes	spike	NNS
cord-269011-230p8rsf	409	20	(	(	-LRB-
cord-269011-230p8rsf	409	21	Bridger	Bridger	NNP
cord-269011-230p8rsf	409	22	et	et	NNP
cord-269011-230p8rsf	409	23	al	al	NNP
cord-269011-230p8rsf	409	24	.	.	.
cord-269011-230p8rsf	410	1	,	,	,
cord-269011-230p8rsf	410	2	1978	1978	CD
cord-269011-230p8rsf	410	3	;	;	:
cord-269011-230p8rsf	410	4	King	King	NNP
cord-269011-230p8rsf	410	5	et	et	NNP
cord-269011-230p8rsf	410	6	al	al	NNP
cord-269011-230p8rsf	410	7	.	.	.
cord-269011-230p8rsf	411	1	,	,	,
cord-269011-230p8rsf	411	2	1985	1985	CD
cord-269011-230p8rsf	411	3	;	;	:
cord-269011-230p8rsf	411	4	Sugiyama	Sugiyama	NNP
cord-269011-230p8rsf	411	5	and	and	CC
cord-269011-230p8rsf	411	6	Amano	Amano	NNP
cord-269011-230p8rsf	411	7	,	,	,
cord-269011-230p8rsf	411	8	1981	1981	CD
cord-269011-230p8rsf	411	9	)	)	-RRB-
cord-269011-230p8rsf	411	10	.	.	.
cord-269011-230p8rsf	412	1	These	these	DT
cord-269011-230p8rsf	412	2	viruses	virus	NNS
cord-269011-230p8rsf	412	3	express	express	VBP
cord-269011-230p8rsf	412	4	and	and	CC
cord-269011-230p8rsf	412	5	incorporate	incorporate	VBP
cord-269011-230p8rsf	412	6	into	into	IN
cord-269011-230p8rsf	412	7	their	-PRON-	PRP$
cord-269011-230p8rsf	412	8	particles	particle	NNS
cord-269011-230p8rsf	412	9	an	an	DT
cord-269011-230p8rsf	412	10	additional	additional	JJ
cord-269011-230p8rsf	412	11	membrane	membrane	NN
cord-269011-230p8rsf	412	12	protein	protein	NN
cord-269011-230p8rsf	412	13	,	,	,
cord-269011-230p8rsf	412	14	HE	he	PRP
cord-269011-230p8rsf	412	15	(	(	-LRB-
cord-269011-230p8rsf	412	16	for	for	IN
cord-269011-230p8rsf	412	17	a	a	DT
cord-269011-230p8rsf	412	18	review	review	NN
cord-269011-230p8rsf	412	19	see	see	VBP
cord-269011-230p8rsf	412	20	Brian	Brian	NNP
cord-269011-230p8rsf	412	21	et	et	NNP
cord-269011-230p8rsf	412	22	al	al	NNP
cord-269011-230p8rsf	412	23	.	.	NNP
cord-269011-230p8rsf	412	24	,	,	,
cord-269011-230p8rsf	412	25	1995	1995	CD
cord-269011-230p8rsf	412	26	)	)	-RRB-
cord-269011-230p8rsf	412	27	.	.	.
cord-269011-230p8rsf	413	1	Although	although	IN
cord-269011-230p8rsf	413	2	all	all	DT
cord-269011-230p8rsf	413	3	group	group	NN
cord-269011-230p8rsf	413	4	2	2	CD
cord-269011-230p8rsf	413	5	viruses	virus	NNS
cord-269011-230p8rsf	413	6	contain	contain	VBP
cord-269011-230p8rsf	413	7	an	an	DT
cord-269011-230p8rsf	413	8	HE	HE	NNP
cord-269011-230p8rsf	413	9	gene	gene	NN
cord-269011-230p8rsf	413	10	,	,	,
cord-269011-230p8rsf	413	11	the	the	DT
cord-269011-230p8rsf	413	12	protein	protein	NN
cord-269011-230p8rsf	413	13	is	be	VBZ
cord-269011-230p8rsf	413	14	not	not	RB
cord-269011-230p8rsf	413	15	expressed	express	VBN
cord-269011-230p8rsf	413	16	by	by	IN
cord-269011-230p8rsf	413	17	all	all	DT
cord-269011-230p8rsf	413	18	MHV	MHV	NNP
cord-269011-230p8rsf	413	19	strains	strain	NNS
cord-269011-230p8rsf	413	20	(	(	-LRB-
cord-269011-230p8rsf	413	21	Luytjes	Luytjes	NNP
cord-269011-230p8rsf	413	22	et	et	NNP
cord-269011-230p8rsf	413	23	al	al	NNP
cord-269011-230p8rsf	413	24	.	.	NNP
cord-269011-230p8rsf	413	25	,	,	,
cord-269011-230p8rsf	413	26	1988	1988	CD
cord-269011-230p8rsf	413	27	;	;	:
cord-269011-230p8rsf	413	28	Yokomori	Yokomori	NNP
cord-269011-230p8rsf	413	29	et	et	NNP
cord-269011-230p8rsf	413	30	al	al	NNP
cord-269011-230p8rsf	413	31	.	.	NNP
cord-269011-230p8rsf	413	32	,	,	,
cord-269011-230p8rsf	413	33	1991	1991	CD
cord-269011-230p8rsf	413	34	)	)	-RRB-
cord-269011-230p8rsf	413	35	,	,	,
cord-269011-230p8rsf	413	36	indicating	indicate	VBG
cord-269011-230p8rsf	413	37	that	that	IN
cord-269011-230p8rsf	413	38	HE	he	PRP
cord-269011-230p8rsf	413	39	is	be	VBZ
cord-269011-230p8rsf	413	40	a	a	DT
cord-269011-230p8rsf	413	41	nonessential	nonessential	JJ
cord-269011-230p8rsf	413	42	protein	protein	NN
cord-269011-230p8rsf	413	43	also	also	RB
cord-269011-230p8rsf	413	44	in	in	IN
cord-269011-230p8rsf	413	45	these	these	DT
cord-269011-230p8rsf	413	46	viruses	virus	NNS
cord-269011-230p8rsf	413	47	.	.	.
cord-269011-230p8rsf	414	1	The	the	DT
cord-269011-230p8rsf	414	2	HE	HE	NNP
cord-269011-230p8rsf	414	3	gene	gene	NN
cord-269011-230p8rsf	414	4	encodes	encode	VBZ
cord-269011-230p8rsf	414	5	a	a	DT
cord-269011-230p8rsf	414	6	type	type	NN
cord-269011-230p8rsf	414	7	I	-PRON-	PRP
cord-269011-230p8rsf	414	8	membrane	membrane	VBP
cord-269011-230p8rsf	414	9	protein	protein	NN
cord-269011-230p8rsf	414	10	of	of	IN
cord-269011-230p8rsf	414	11	424	424	CD
cord-269011-230p8rsf	414	12	-	-	SYM
cord-269011-230p8rsf	414	13	439	439	CD
cord-269011-230p8rsf	414	14	residues	residue	NNS
cord-269011-230p8rsf	414	15	that	that	WDT
cord-269011-230p8rsf	414	16	contains	contain	VBZ
cord-269011-230p8rsf	414	17	a	a	DT
cord-269011-230p8rsf	414	18	cleavable	cleavable	JJ
cord-269011-230p8rsf	414	19	signal	signal	NN
cord-269011-230p8rsf	414	20	peptide	peptide	NN
cord-269011-230p8rsf	414	21	at	at	IN
cord-269011-230p8rsf	414	22	its	-PRON-	PRP$
cord-269011-230p8rsf	414	23	amino	amino	NN
cord-269011-230p8rsf	414	24	terminus	terminus	NN
cord-269011-230p8rsf	414	25	(	(	-LRB-
cord-269011-230p8rsf	414	26	Hogue	Hogue	NNP
cord-269011-230p8rsf	414	27	et	et	NNP
cord-269011-230p8rsf	414	28	al	al	NNP
cord-269011-230p8rsf	414	29	.	.	NNP
cord-269011-230p8rsf	414	30	,	,	,
cord-269011-230p8rsf	414	31	1989	1989	CD
cord-269011-230p8rsf	414	32	;	;	:
cord-269011-230p8rsf	414	33	Kienzle	Kienzle	NNP
cord-269011-230p8rsf	414	34	et	et	NNP
cord-269011-230p8rsf	414	35	al	al	NNP
cord-269011-230p8rsf	414	36	.	.	NNP
cord-269011-230p8rsf	414	37	,	,	,
cord-269011-230p8rsf	414	38	1990	1990	CD
cord-269011-230p8rsf	414	39	)	)	-RRB-
cord-269011-230p8rsf	414	40	and	and	CC
cord-269011-230p8rsf	414	41	a	a	DT
cord-269011-230p8rsf	414	42	transmembrane	transmembrane	NN
cord-269011-230p8rsf	414	43	domain	domain	NN
cord-269011-230p8rsf	414	44	close	close	JJ
cord-269011-230p8rsf	414	45	to	to	IN
cord-269011-230p8rsf	414	46	its	-PRON-	PRP$
cord-269011-230p8rsf	414	47	carboxy	carboxy	JJ
cord-269011-230p8rsf	414	48	terminus	terminus	NN
cord-269011-230p8rsf	414	49	,	,	,
cord-269011-230p8rsf	414	50	leaving	leave	VBG
cord-269011-230p8rsf	414	51	a	a	DT
cord-269011-230p8rsf	414	52	short	short	JJ
cord-269011-230p8rsf	414	53	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	414	54	tail	tail	NN
cord-269011-230p8rsf	414	55	of	of	IN
cord-269011-230p8rsf	414	56	about	about	IN
cord-269011-230p8rsf	414	57	10	10	CD
cord-269011-230p8rsf	414	58	residues	residue	NNS
cord-269011-230p8rsf	414	59	(	(	-LRB-
cord-269011-230p8rsf	414	60	Fig	Fig	NNP
cord-269011-230p8rsf	414	61	.	.	NNP
cord-269011-230p8rsf	414	62	4	4	CD
cord-269011-230p8rsf	414	63	)	)	-RRB-
cord-269011-230p8rsf	414	64	.	.	.
cord-269011-230p8rsf	415	1	The	the	DT
cord-269011-230p8rsf	415	2	ectodomain	ectodomain	NN
cord-269011-230p8rsf	415	3	contains	contain	VBZ
cord-269011-230p8rsf	415	4	8	8	CD
cord-269011-230p8rsf	415	5	-	-	SYM
cord-269011-230p8rsf	415	6	10	10	CD
cord-269011-230p8rsf	415	7	putative	putative	JJ
cord-269011-230p8rsf	415	8	N	n	CD
cord-269011-230p8rsf	415	9	-	-	HYPH
cord-269011-230p8rsf	415	10	linked	link	VBN
cord-269011-230p8rsf	415	11	glycosylation	glycosylation	NN
cord-269011-230p8rsf	415	12	sites	site	NNS
cord-269011-230p8rsf	415	13	.	.	.
cord-269011-230p8rsf	416	1	The	the	DT
cord-269011-230p8rsf	416	2	putative	putative	JJ
cord-269011-230p8rsf	416	3	esterase	esterase	NN
cord-269011-230p8rsf	416	4	active	active	JJ
cord-269011-230p8rsf	416	5	site	site	NN
cord-269011-230p8rsf	416	6	(	(	-LRB-
cord-269011-230p8rsf	416	7	FGDS	FGDS	NNP
cord-269011-230p8rsf	416	8	)	)	-RRB-
cord-269011-230p8rsf	416	9	is	be	VBZ
cord-269011-230p8rsf	416	10	located	locate	VBN
cord-269011-230p8rsf	416	11	near	near	IN
cord-269011-230p8rsf	416	12	the	the	DT
cord-269011-230p8rsf	416	13	(	(	-LRB-
cord-269011-230p8rsf	416	14	signal	signal	NN
cord-269011-230p8rsf	416	15	-	-	HYPH
cord-269011-230p8rsf	416	16	cleaved	cleave	VBN
cord-269011-230p8rsf	416	17	)	)	-RRB-
cord-269011-230p8rsf	416	18	HE	HE	NNP
cord-269011-230p8rsf	416	19	amino	amino	NN
cord-269011-230p8rsf	416	20	terminus	terminus	NN
cord-269011-230p8rsf	416	21	.	.	.
cord-269011-230p8rsf	417	1	The	the	DT
cord-269011-230p8rsf	417	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	417	3	HE	HE	NNP
cord-269011-230p8rsf	417	4	protein	protein	NN
cord-269011-230p8rsf	417	5	has	have	VBZ
cord-269011-230p8rsf	417	6	30	30	CD
cord-269011-230p8rsf	417	7	%	%	NN
cord-269011-230p8rsf	417	8	amino	amino	NN
cord-269011-230p8rsf	417	9	acid	acid	NN
cord-269011-230p8rsf	417	10	identity	identity	NN
cord-269011-230p8rsf	417	11	with	with	IN
cord-269011-230p8rsf	417	12	the	the	DT
cord-269011-230p8rsf	417	13	HE-1	HE-1	NNP
cord-269011-230p8rsf	417	14	subunit	subunit	NN
cord-269011-230p8rsf	417	15	of	of	IN
cord-269011-230p8rsf	417	16	the	the	DT
cord-269011-230p8rsf	417	17	HE	HE	NNP
cord-269011-230p8rsf	417	18	fusion	fusion	NN
cord-269011-230p8rsf	417	19	protein	protein	NN
cord-269011-230p8rsf	417	20	of	of	IN
cord-269011-230p8rsf	417	21	influenza	influenza	NN
cord-269011-230p8rsf	417	22	C	C	NNP
cord-269011-230p8rsf	417	23	virus	virus	NN
cord-269011-230p8rsf	417	24	and	and	CC
cord-269011-230p8rsf	417	25	the	the	DT
cord-269011-230p8rsf	417	26	HE	HE	NNP
cord-269011-230p8rsf	417	27	protein	protein	NN
cord-269011-230p8rsf	417	28	of	of	IN
cord-269011-230p8rsf	417	29	torovirus	torovirus	NNP
cord-269011-230p8rsf	418	1	(	(	-LRB-
cord-269011-230p8rsf	418	2	Cornelissen	Cornelissen	NNP
cord-269011-230p8rsf	418	3	et	et	NNP
cord-269011-230p8rsf	418	4	al	al	NNP
cord-269011-230p8rsf	418	5	.	.	NNP
cord-269011-230p8rsf	418	6	,	,	,
cord-269011-230p8rsf	418	7	1997	1997	CD
cord-269011-230p8rsf	418	8	)	)	-RRB-
cord-269011-230p8rsf	418	9	.	.	.
cord-269011-230p8rsf	419	1	It	-PRON-	PRP
cord-269011-230p8rsf	419	2	has	have	VBZ
cord-269011-230p8rsf	419	3	been	be	VBN
cord-269011-230p8rsf	419	4	suggested	suggest	VBN
cord-269011-230p8rsf	419	5	that	that	IN
cord-269011-230p8rsf	419	6	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	419	7	have	have	VBP
cord-269011-230p8rsf	419	8	captured	capture	VBN
cord-269011-230p8rsf	419	9	their	-PRON-	PRP$
cord-269011-230p8rsf	419	10	HE	HE	NNP
cord-269011-230p8rsf	419	11	module	module	NN
cord-269011-230p8rsf	419	12	from	from	IN
cord-269011-230p8rsf	419	13	influenza	influenza	NN
cord-269011-230p8rsf	419	14	C	C	NNP
cord-269011-230p8rsf	419	15	virus	virus	NN
cord-269011-230p8rsf	419	16	or	or	CC
cord-269011-230p8rsf	419	17	a	a	DT
cord-269011-230p8rsf	419	18	related	related	JJ
cord-269011-230p8rsf	419	19	virus	virus	NN
cord-269011-230p8rsf	420	1	(	(	-LRB-
cord-269011-230p8rsf	420	2	Luytjes	Luytjes	NNP
cord-269011-230p8rsf	420	3	et	et	NNP
cord-269011-230p8rsf	420	4	al	al	NNP
cord-269011-230p8rsf	420	5	.	.	NNP
cord-269011-230p8rsf	420	6	,	,	,
cord-269011-230p8rsf	420	7	1988	1988	CD
cord-269011-230p8rsf	420	8	)	)	-RRB-
cord-269011-230p8rsf	420	9	.	.	.
cord-269011-230p8rsf	421	1	However	however	RB
cord-269011-230p8rsf	421	2	,	,	,
cord-269011-230p8rsf	421	3	influenza	influenza	NN
cord-269011-230p8rsf	421	4	C	c	NN
cord-269011-230p8rsf	421	5	virus	virus	NN
cord-269011-230p8rsf	421	6	,	,	,
cord-269011-230p8rsf	421	7	toroviruses	toroviruse	NNS
cord-269011-230p8rsf	421	8	,	,	,
cord-269011-230p8rsf	421	9	and	and	CC
cord-269011-230p8rsf	421	10	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	421	11	may	may	MD
cord-269011-230p8rsf	421	12	well	well	RB
cord-269011-230p8rsf	421	13	have	have	VB
cord-269011-230p8rsf	421	14	acquired	acquire	VBN
cord-269011-230p8rsf	421	15	their	-PRON-	PRP$
cord-269011-230p8rsf	421	16	HE	HE	NNP
cord-269011-230p8rsf	421	17	sequences	sequence	NNS
cord-269011-230p8rsf	421	18	independently	independently	RB
cord-269011-230p8rsf	421	19	,	,	,
cord-269011-230p8rsf	421	20	not	not	RB
cord-269011-230p8rsf	421	21	from	from	IN
cord-269011-230p8rsf	421	22	each	each	DT
cord-269011-230p8rsf	421	23	other	other	JJ
cord-269011-230p8rsf	421	24	but	but	CC
cord-269011-230p8rsf	421	25	from	from	IN
cord-269011-230p8rsf	421	26	yet	yet	RB
cord-269011-230p8rsf	421	27	another	another	DT
cord-269011-230p8rsf	421	28	source	source	NN
cord-269011-230p8rsf	421	29	(	(	-LRB-
cord-269011-230p8rsf	421	30	Cornelissen	Cornelissen	NNP
cord-269011-230p8rsf	421	31	et	et	NNP
cord-269011-230p8rsf	421	32	al	al	NNP
cord-269011-230p8rsf	421	33	.	.	NNP
cord-269011-230p8rsf	421	34	,	,	,
cord-269011-230p8rsf	421	35	1997	1997	CD
cord-269011-230p8rsf	421	36	)	)	-RRB-
cord-269011-230p8rsf	421	37	.	.	.
cord-269011-230p8rsf	422	1	The	the	DT
cord-269011-230p8rsf	422	2	HE	HE	NNP
cord-269011-230p8rsf	422	3	protein	protein	NN
cord-269011-230p8rsf	422	4	becomes	become	VBZ
cord-269011-230p8rsf	422	5	cotranslationally	cotranslationally	RB
cord-269011-230p8rsf	422	6	N	n	CD
cord-269011-230p8rsf	422	7	-	-	HYPH
cord-269011-230p8rsf	422	8	glycosylated	glycosylate	VBN
cord-269011-230p8rsf	422	9	when	when	WRB
cord-269011-230p8rsf	422	10	expressed	express	VBN
cord-269011-230p8rsf	422	11	in	in	IN
cord-269011-230p8rsf	422	12	cells	cell	NNS
cord-269011-230p8rsf	422	13	,	,	,
cord-269011-230p8rsf	422	14	giving	give	VBG
cord-269011-230p8rsf	422	15	rise	rise	NN
cord-269011-230p8rsf	422	16	to	to	IN
cord-269011-230p8rsf	422	17	a	a	DT
cord-269011-230p8rsf	422	18	polypeptide	polypeptide	NN
cord-269011-230p8rsf	422	19	of	of	IN
cord-269011-230p8rsf	422	20	approximately	approximately	RB
cord-269011-230p8rsf	422	21	60	60	CD
cord-269011-230p8rsf	422	22	-	-	SYM
cord-269011-230p8rsf	422	23	65	65	CD
cord-269011-230p8rsf	422	24	kDa	kDa	NNS
cord-269011-230p8rsf	422	25	that	that	IN
cord-269011-230p8rsf	422	26	rapidly	rapidly	RB
cord-269011-230p8rsf	422	27	forms	form	VBZ
cord-269011-230p8rsf	422	28	disulfide	disulfide	RB
cord-269011-230p8rsf	422	29	-	-	HYPH
cord-269011-230p8rsf	422	30	linked	link	VBN
cord-269011-230p8rsf	422	31	dimers	dimer	NNS
cord-269011-230p8rsf	422	32	(	(	-LRB-
cord-269011-230p8rsf	422	33	Hogue	Hogue	NNP
cord-269011-230p8rsf	422	34	et	et	NNP
cord-269011-230p8rsf	422	35	al	al	NNP
cord-269011-230p8rsf	422	36	.	.	.
cord-269011-230p8rsf	423	1	,	,	,
cord-269011-230p8rsf	423	2	1989	1989	CD
cord-269011-230p8rsf	423	3	;	;	:
cord-269011-230p8rsf	423	4	Kienzle	Kienzle	NNP
cord-269011-230p8rsf	423	5	et	et	NNP
cord-269011-230p8rsf	423	6	al	al	NNP
cord-269011-230p8rsf	423	7	.	.	.
cord-269011-230p8rsf	424	1	,	,	,
cord-269011-230p8rsf	424	2	1990	1990	CD
cord-269011-230p8rsf	424	3	;	;	:
cord-269011-230p8rsf	424	4	King	King	NNP
cord-269011-230p8rsf	424	5	et	et	NNP
cord-269011-230p8rsf	424	6	al	al	NNP
cord-269011-230p8rsf	424	7	.	.	NNP
cord-269011-230p8rsf	424	8	,	,	,
cord-269011-230p8rsf	424	9	1985	1985	CD
cord-269011-230p8rsf	424	10	;	;	:
cord-269011-230p8rsf	424	11	Parker	Parker	NNP
cord-269011-230p8rsf	424	12	et	et	NNP
cord-269011-230p8rsf	424	13	al	al	NNP
cord-269011-230p8rsf	424	14	.	.	NNP
cord-269011-230p8rsf	424	15	,	,	,
cord-269011-230p8rsf	424	16	1989	1989	CD
cord-269011-230p8rsf	424	17	;	;	:
cord-269011-230p8rsf	425	1	Yokomori	Yokomori	NNP
cord-269011-230p8rsf	425	2	et	et	NNP
cord-269011-230p8rsf	425	3	al	al	NNP
cord-269011-230p8rsf	425	4	.	.	NNP
cord-269011-230p8rsf	425	5	,	,	,
cord-269011-230p8rsf	425	6	1989	1989	CD
cord-269011-230p8rsf	425	7	;	;	:
cord-269011-230p8rsf	425	8	Yoo	Yoo	NNP
cord-269011-230p8rsf	425	9	et	et	NNP
cord-269011-230p8rsf	425	10	al	al	NNP
cord-269011-230p8rsf	425	11	.	.	NNP
cord-269011-230p8rsf	425	12	,	,	,
cord-269011-230p8rsf	425	13	1992	1992	CD
cord-269011-230p8rsf	425	14	)	)	-RRB-
cord-269011-230p8rsf	425	15	.	.	.
cord-269011-230p8rsf	426	1	The	the	DT
cord-269011-230p8rsf	426	2	HE	HE	NNP
cord-269011-230p8rsf	426	3	dimers	dimer	NNS
cord-269011-230p8rsf	426	4	(	(	-LRB-
cord-269011-230p8rsf	426	5	or	or	CC
cord-269011-230p8rsf	426	6	a	a	DT
cord-269011-230p8rsf	426	7	higher	high	JJR
cord-269011-230p8rsf	426	8	order	order	NN
cord-269011-230p8rsf	426	9	structure	structure	NN
cord-269011-230p8rsf	426	10	thereof	thereof	RB
cord-269011-230p8rsf	426	11	)	)	-RRB-
cord-269011-230p8rsf	427	1	become	become	VB
cord-269011-230p8rsf	427	2	incorporated	incorporate	VBN
cord-269011-230p8rsf	427	3	into	into	IN
cord-269011-230p8rsf	427	4	virions	virion	NNS
cord-269011-230p8rsf	427	5	,	,	,
cord-269011-230p8rsf	427	6	while	while	IN
cord-269011-230p8rsf	427	7	a	a	DT
cord-269011-230p8rsf	427	8	proportion	proportion	NN
cord-269011-230p8rsf	427	9	is	be	VBZ
cord-269011-230p8rsf	427	10	transported	transport	VBN
cord-269011-230p8rsf	427	11	to	to	IN
cord-269011-230p8rsf	427	12	the	the	DT
cord-269011-230p8rsf	427	13	cell	cell	NN
cord-269011-230p8rsf	427	14	surface	surface	NN
cord-269011-230p8rsf	427	15	(	(	-LRB-
cord-269011-230p8rsf	427	16	Kienzle	Kienzle	NNP
cord-269011-230p8rsf	427	17	et	et	NNP
cord-269011-230p8rsf	427	18	al	al	NNP
cord-269011-230p8rsf	427	19	.	.	NNP
cord-269011-230p8rsf	427	20	,	,	,
cord-269011-230p8rsf	427	21	1990	1990	CD
cord-269011-230p8rsf	427	22	;	;	:
cord-269011-230p8rsf	428	1	Pfleiderer	Pfleiderer	NNP
cord-269011-230p8rsf	428	2	et	et	NNP
cord-269011-230p8rsf	428	3	al	al	NNP
cord-269011-230p8rsf	428	4	.	.	NNP
cord-269011-230p8rsf	428	5	,	,	,
cord-269011-230p8rsf	428	6	1991	1991	CD
cord-269011-230p8rsf	428	7	)	)	-RRB-
cord-269011-230p8rsf	428	8	.	.	.
cord-269011-230p8rsf	429	1	Little	little	JJ
cord-269011-230p8rsf	429	2	is	be	VBZ
cord-269011-230p8rsf	429	3	still	still	RB
cord-269011-230p8rsf	429	4	known	know	VBN
cord-269011-230p8rsf	429	5	about	about	IN
cord-269011-230p8rsf	429	6	the	the	DT
cord-269011-230p8rsf	429	7	function(s	function(s	NNP
cord-269011-230p8rsf	429	8	)	)	-RRB-
cord-269011-230p8rsf	429	9	of	of	IN
cord-269011-230p8rsf	429	10	the	the	DT
cord-269011-230p8rsf	429	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	429	12	HE	he	PRP
cord-269011-230p8rsf	429	13	protein	protein	NN
cord-269011-230p8rsf	429	14	.	.	.
cord-269011-230p8rsf	430	1	The	the	DT
cord-269011-230p8rsf	430	2	protein	protein	NN
cord-269011-230p8rsf	430	3	contains	contain	VBZ
cord-269011-230p8rsf	430	4	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	430	5	and	and	CC
cord-269011-230p8rsf	430	6	acetyl	acetyl	NN
cord-269011-230p8rsf	430	7	esterase	esterase	NN
cord-269011-230p8rsf	430	8	activities	activity	NNS
cord-269011-230p8rsf	430	9	(	(	-LRB-
cord-269011-230p8rsf	430	10	Brian	Brian	NNP
cord-269011-230p8rsf	430	11	et	et	NNP
cord-269011-230p8rsf	430	12	al	al	NNP
cord-269011-230p8rsf	430	13	.	.	NNP
cord-269011-230p8rsf	430	14	,	,	,
cord-269011-230p8rsf	430	15	1995	1995	CD
cord-269011-230p8rsf	430	16	)	)	-RRB-
cord-269011-230p8rsf	430	17	.	.	.
cord-269011-230p8rsf	431	1	While	while	IN
cord-269011-230p8rsf	431	2	the	the	DT
cord-269011-230p8rsf	431	3	HE	HE	NNP
cord-269011-230p8rsf	431	4	proteins	protein	VBZ
cord-269011-230p8rsf	431	5	of	of	IN
cord-269011-230p8rsf	431	6	BCoV	BCoV	NNP
cord-269011-230p8rsf	431	7	,	,	,
cord-269011-230p8rsf	431	8	HEV	HEV	NNP
cord-269011-230p8rsf	431	9	,	,	,
cord-269011-230p8rsf	431	10	and	and	CC
cord-269011-230p8rsf	431	11	HCoV	HCoV	NNP
cord-269011-230p8rsf	431	12	-	-	HYPH
cord-269011-230p8rsf	431	13	OC43	OC43	NNP
cord-269011-230p8rsf	431	14	hydrolyze	hydrolyze	VB
cord-269011-230p8rsf	431	15	the	the	DT
cord-269011-230p8rsf	431	16	9-O	9-o	CD
cord-269011-230p8rsf	431	17	-	-	HYPH
cord-269011-230p8rsf	431	18	acetyl	acetyl	NN
cord-269011-230p8rsf	431	19	group	group	NN
cord-269011-230p8rsf	431	20	of	of	IN
cord-269011-230p8rsf	431	21	sialic	sialic	JJ
cord-269011-230p8rsf	431	22	acid	acid	NN
cord-269011-230p8rsf	431	23	and	and	CC
cord-269011-230p8rsf	431	24	therefore	therefore	RB
cord-269011-230p8rsf	431	25	appear	appear	VB
cord-269011-230p8rsf	431	26	to	to	TO
cord-269011-230p8rsf	431	27	function	function	VB
cord-269011-230p8rsf	431	28	as	as	IN
cord-269011-230p8rsf	431	29	receptor	receptor	NN
cord-269011-230p8rsf	431	30	-	-	HYPH
cord-269011-230p8rsf	431	31	destroying	destroy	VBG
cord-269011-230p8rsf	431	32	enzymes	enzyme	NNS
cord-269011-230p8rsf	432	1	(	(	-LRB-
cord-269011-230p8rsf	432	2	Schultze	Schultze	NNP
cord-269011-230p8rsf	432	3	et	et	NNP
cord-269011-230p8rsf	432	4	al	al	NNP
cord-269011-230p8rsf	432	5	.	.	NNP
cord-269011-230p8rsf	432	6	,	,	,
cord-269011-230p8rsf	432	7	1991b	1991b	CD
cord-269011-230p8rsf	432	8	;	;	:
cord-269011-230p8rsf	432	9	Vlasak	Vlasak	NNP
cord-269011-230p8rsf	432	10	et	et	NNP
cord-269011-230p8rsf	432	11	al	al	NNP
cord-269011-230p8rsf	432	12	.	.	NNP
cord-269011-230p8rsf	432	13	,	,	,
cord-269011-230p8rsf	432	14	1988a	1988a	CD
cord-269011-230p8rsf	432	15	)	)	-RRB-
cord-269011-230p8rsf	433	1	,	,	,
cord-269011-230p8rsf	433	2	the	the	DT
cord-269011-230p8rsf	433	3	HE	HE	NNP
cord-269011-230p8rsf	433	4	proteins	protein	NNS
cord-269011-230p8rsf	433	5	of	of	IN
cord-269011-230p8rsf	433	6	MHVlike	mhvlike	NN
cord-269011-230p8rsf	433	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	433	8	function	function	NN
cord-269011-230p8rsf	433	9	as	as	IN
cord-269011-230p8rsf	433	10	sialate-4-O	sialate-4-O	NNP
cord-269011-230p8rsf	433	11	-	-	HYPH
cord-269011-230p8rsf	433	12	acetylesterases	acetylesterases	NNP
cord-269011-230p8rsf	433	13	(	(	-LRB-
cord-269011-230p8rsf	433	14	Klausegger	Klausegger	NNP
cord-269011-230p8rsf	433	15	et	et	NNP
cord-269011-230p8rsf	433	16	al	al	NNP
cord-269011-230p8rsf	433	17	.	.	NNP
cord-269011-230p8rsf	433	18	,	,	,
cord-269011-230p8rsf	433	19	1999	1999	CD
cord-269011-230p8rsf	433	20	;	;	:
cord-269011-230p8rsf	434	1	Regl	Regl	NNP
cord-269011-230p8rsf	434	2	et	et	FW
cord-269011-230p8rsf	434	3	al	al	NNP
cord-269011-230p8rsf	434	4	.	.	NNP
cord-269011-230p8rsf	434	5	,	,	,
cord-269011-230p8rsf	434	6	1999	1999	CD
cord-269011-230p8rsf	434	7	;	;	:
cord-269011-230p8rsf	434	8	Wurzer	Wurzer	NNP
cord-269011-230p8rsf	434	9	et	et	NNP
cord-269011-230p8rsf	434	10	al	al	NNP
cord-269011-230p8rsf	434	11	.	.	NNP
cord-269011-230p8rsf	434	12	,	,	,
cord-269011-230p8rsf	434	13	2002	2002	CD
cord-269011-230p8rsf	434	14	)	)	-RRB-
cord-269011-230p8rsf	434	15	.	.	.
cord-269011-230p8rsf	435	1	Although	although	IN
cord-269011-230p8rsf	435	2	inhibition	inhibition	NN
cord-269011-230p8rsf	435	3	of	of	IN
cord-269011-230p8rsf	435	4	the	the	DT
cord-269011-230p8rsf	435	5	esterase	esterase	NN
cord-269011-230p8rsf	435	6	activity	activity	NN
cord-269011-230p8rsf	435	7	of	of	IN
cord-269011-230p8rsf	435	8	BCoV	BCoV	NNP
cord-269011-230p8rsf	435	9	resulted	result	VBD
cord-269011-230p8rsf	435	10	in	in	IN
cord-269011-230p8rsf	435	11	a	a	DT
cord-269011-230p8rsf	435	12	100-to	100-to	CD
cord-269011-230p8rsf	435	13	400-fold	400-fold	CD
cord-269011-230p8rsf	435	14	reduction	reduction	NN
cord-269011-230p8rsf	435	15	in	in	IN
cord-269011-230p8rsf	435	16	viral	viral	JJ
cord-269011-230p8rsf	435	17	infectivity	infectivity	NN
cord-269011-230p8rsf	435	18	(	(	-LRB-
cord-269011-230p8rsf	435	19	Vlasak	Vlasak	NNP
cord-269011-230p8rsf	435	20	et	et	NNP
cord-269011-230p8rsf	435	21	al	al	NNP
cord-269011-230p8rsf	435	22	.	.	NNP
cord-269011-230p8rsf	435	23	,	,	,
cord-269011-230p8rsf	435	24	1988a	1988a	CD
cord-269011-230p8rsf	435	25	)	)	-RRB-
cord-269011-230p8rsf	435	26	,	,	,
cord-269011-230p8rsf	435	27	it	-PRON-	PRP
cord-269011-230p8rsf	435	28	was	be	VBD
cord-269011-230p8rsf	435	29	shown	show	VBN
cord-269011-230p8rsf	435	30	both	both	DT
cord-269011-230p8rsf	435	31	for	for	IN
cord-269011-230p8rsf	435	32	BCoV	BCoV	NNP
cord-269011-230p8rsf	435	33	and	and	CC
cord-269011-230p8rsf	435	34	for	for	IN
cord-269011-230p8rsf	435	35	an	an	DT
cord-269011-230p8rsf	435	36	MHV	MHV	NNP
cord-269011-230p8rsf	435	37	strain	strain	NN
cord-269011-230p8rsf	435	38	expressing	express	VBG
cord-269011-230p8rsf	435	39	an	an	DT
cord-269011-230p8rsf	435	40	HE	HE	NNP
cord-269011-230p8rsf	435	41	gene	gene	NN
cord-269011-230p8rsf	435	42	that	that	IN
cord-269011-230p8rsf	435	43	the	the	DT
cord-269011-230p8rsf	435	44	S	S	NNP
cord-269011-230p8rsf	435	45	protein	protein	NN
cord-269011-230p8rsf	435	46	is	be	VBZ
cord-269011-230p8rsf	435	47	required	require	VBN
cord-269011-230p8rsf	435	48	and	and	CC
cord-269011-230p8rsf	435	49	sufficient	sufficient	JJ
cord-269011-230p8rsf	435	50	for	for	IN
cord-269011-230p8rsf	435	51	infection	infection	NN
cord-269011-230p8rsf	435	52	(	(	-LRB-
cord-269011-230p8rsf	435	53	Gagneten	Gagneten	NNP
cord-269011-230p8rsf	435	54	et	et	FW
cord-269011-230p8rsf	435	55	al	al	NNP
cord-269011-230p8rsf	435	56	.	.	.
cord-269011-230p8rsf	436	1	,	,	,
cord-269011-230p8rsf	436	2	1995	1995	CD
cord-269011-230p8rsf	436	3	;	;	:
cord-269011-230p8rsf	436	4	Popova	Popova	NNP
cord-269011-230p8rsf	436	5	and	and	CC
cord-269011-230p8rsf	436	6	Zhang	Zhang	NNP
cord-269011-230p8rsf	436	7	,	,	,
cord-269011-230p8rsf	436	8	2002	2002	CD
cord-269011-230p8rsf	436	9	)	)	-RRB-
cord-269011-230p8rsf	436	10	.	.	.
cord-269011-230p8rsf	437	1	In	in	IN
cord-269011-230p8rsf	437	2	view	view	NN
cord-269011-230p8rsf	437	3	of	of	IN
cord-269011-230p8rsf	437	4	these	these	DT
cord-269011-230p8rsf	437	5	results	result	NNS
cord-269011-230p8rsf	437	6	it	-PRON-	PRP
cord-269011-230p8rsf	437	7	has	have	VBZ
cord-269011-230p8rsf	437	8	been	be	VBN
cord-269011-230p8rsf	437	9	proposed	propose	VBN
cord-269011-230p8rsf	437	10	that	that	IN
cord-269011-230p8rsf	437	11	the	the	DT
cord-269011-230p8rsf	437	12	HE	HE	NNP
cord-269011-230p8rsf	437	13	protein	protein	NN
cord-269011-230p8rsf	437	14	might	may	MD
cord-269011-230p8rsf	437	15	play	play	VB
cord-269011-230p8rsf	437	16	a	a	DT
cord-269011-230p8rsf	437	17	role	role	NN
cord-269011-230p8rsf	437	18	at	at	IN
cord-269011-230p8rsf	437	19	an	an	DT
cord-269011-230p8rsf	437	20	even	even	RB
cord-269011-230p8rsf	437	21	earlier	early	JJR
cord-269011-230p8rsf	437	22	step	step	NN
cord-269011-230p8rsf	437	23	and	and	CC
cord-269011-230p8rsf	437	24	may	may	MD
cord-269011-230p8rsf	437	25	mediate	mediate	VB
cord-269011-230p8rsf	437	26	viral	viral	JJ
cord-269011-230p8rsf	437	27	adherence	adherence	NN
cord-269011-230p8rsf	437	28	to	to	IN
cord-269011-230p8rsf	437	29	the	the	DT
cord-269011-230p8rsf	437	30	intestinal	intestinal	JJ
cord-269011-230p8rsf	437	31	wall	wall	NN
cord-269011-230p8rsf	437	32	through	through	IN
cord-269011-230p8rsf	437	33	the	the	DT
cord-269011-230p8rsf	437	34	specific	specific	JJ
cord-269011-230p8rsf	437	35	yet	yet	CC
cord-269011-230p8rsf	437	36	reversible	reversible	JJ
cord-269011-230p8rsf	437	37	binding	binding	NN
cord-269011-230p8rsf	437	38	to	to	IN
cord-269011-230p8rsf	437	39	mucopolysaccharides	mucopolysaccharide	NNS
cord-269011-230p8rsf	437	40	.	.	.
cord-269011-230p8rsf	438	1	The	the	DT
cord-269011-230p8rsf	438	2	process	process	NN
cord-269011-230p8rsf	438	3	of	of	IN
cord-269011-230p8rsf	438	4	binding	bind	VBG
cord-269011-230p8rsf	438	5	to	to	IN
cord-269011-230p8rsf	438	6	sialic	sialic	JJ
cord-269011-230p8rsf	438	7	acid	acid	NN
cord-269011-230p8rsf	438	8	receptors	receptor	NNS
cord-269011-230p8rsf	438	9	followed	follow	VBN
cord-269011-230p8rsf	438	10	by	by	IN
cord-269011-230p8rsf	438	11	cleavage	cleavage	NN
cord-269011-230p8rsf	438	12	and	and	CC
cord-269011-230p8rsf	438	13	rebinding	rebinding	NN
cord-269011-230p8rsf	438	14	to	to	IN
cord-269011-230p8rsf	438	15	intact	intact	JJ
cord-269011-230p8rsf	438	16	receptors	receptor	NNS
cord-269011-230p8rsf	438	17	could	could	MD
cord-269011-230p8rsf	438	18	theoretically	theoretically	RB
cord-269011-230p8rsf	438	19	result	result	VB
cord-269011-230p8rsf	438	20	in	in	IN
cord-269011-230p8rsf	438	21	virus	virus	NN
cord-269011-230p8rsf	438	22	motility	motility	NN
cord-269011-230p8rsf	438	23	and	and	CC
cord-269011-230p8rsf	438	24	even	even	RB
cord-269011-230p8rsf	438	25	allow	allow	VB
cord-269011-230p8rsf	438	26	migration	migration	NN
cord-269011-230p8rsf	438	27	through	through	IN
cord-269011-230p8rsf	438	28	the	the	DT
cord-269011-230p8rsf	438	29	mucus	mucus	NN
cord-269011-230p8rsf	438	30	layer	layer	NN
cord-269011-230p8rsf	438	31	covering	cover	VBG
cord-269011-230p8rsf	438	32	the	the	DT
cord-269011-230p8rsf	438	33	epithelial	epithelial	JJ
cord-269011-230p8rsf	438	34	target	target	NN
cord-269011-230p8rsf	438	35	cells	cell	NNS
cord-269011-230p8rsf	438	36	in	in	IN
cord-269011-230p8rsf	438	37	the	the	DT
cord-269011-230p8rsf	438	38	respiratory	respiratory	JJ
cord-269011-230p8rsf	438	39	and	and	CC
cord-269011-230p8rsf	438	40	enteric	enteric	JJ
cord-269011-230p8rsf	438	41	tracts	tract	NNS
cord-269011-230p8rsf	438	42	(	(	-LRB-
cord-269011-230p8rsf	438	43	Cornelissen	Cornelissen	NNP
cord-269011-230p8rsf	438	44	et	et	NNP
cord-269011-230p8rsf	438	45	al	al	NNP
cord-269011-230p8rsf	438	46	.	.	NNP
cord-269011-230p8rsf	438	47	,	,	,
cord-269011-230p8rsf	438	48	1997	1997	CD
cord-269011-230p8rsf	438	49	)	)	-RRB-
cord-269011-230p8rsf	438	50	.	.	.
cord-269011-230p8rsf	439	1	Several	several	JJ
cord-269011-230p8rsf	439	2	studies	study	NNS
cord-269011-230p8rsf	439	3	have	have	VBP
cord-269011-230p8rsf	439	4	indicated	indicate	VBN
cord-269011-230p8rsf	439	5	the	the	DT
cord-269011-230p8rsf	439	6	HE	HE	NNP
cord-269011-230p8rsf	439	7	protein	protein	NN
cord-269011-230p8rsf	439	8	to	to	TO
cord-269011-230p8rsf	439	9	play	play	VB
cord-269011-230p8rsf	439	10	a	a	DT
cord-269011-230p8rsf	439	11	role	role	NN
cord-269011-230p8rsf	439	12	in	in	IN
cord-269011-230p8rsf	439	13	pathogenicity	pathogenicity	NN
cord-269011-230p8rsf	439	14	.	.	.
cord-269011-230p8rsf	440	1	The	the	DT
cord-269011-230p8rsf	440	2	HE	HE	NNP
cord-269011-230p8rsf	440	3	protein	protein	NN
cord-269011-230p8rsf	440	4	of	of	IN
cord-269011-230p8rsf	440	5	BCoV	BCoV	NNP
cord-269011-230p8rsf	440	6	(	(	-LRB-
cord-269011-230p8rsf	440	7	Deregt	Deregt	NNP
cord-269011-230p8rsf	440	8	and	and	CC
cord-269011-230p8rsf	440	9	Babiuk	Babiuk	NNP
cord-269011-230p8rsf	440	10	,	,	,
cord-269011-230p8rsf	440	11	1987	1987	CD
cord-269011-230p8rsf	440	12	)	)	-RRB-
cord-269011-230p8rsf	440	13	,	,	,
cord-269011-230p8rsf	440	14	but	but	CC
cord-269011-230p8rsf	440	15	not	not	RB
cord-269011-230p8rsf	440	16	that	that	DT
cord-269011-230p8rsf	440	17	of	of	IN
cord-269011-230p8rsf	440	18	MHV	MHV	NNP
cord-269011-230p8rsf	440	19	,	,	,
cord-269011-230p8rsf	440	20	was	be	VBD
cord-269011-230p8rsf	440	21	able	able	JJ
cord-269011-230p8rsf	440	22	to	to	TO
cord-269011-230p8rsf	440	23	induce	induce	VB
cord-269011-230p8rsf	440	24	neutralizing	neutralize	VBG
cord-269011-230p8rsf	440	25	antibodies	antibody	NNS
cord-269011-230p8rsf	440	26	.	.	.
cord-269011-230p8rsf	441	1	However	however	RB
cord-269011-230p8rsf	441	2	,	,	,
cord-269011-230p8rsf	441	3	passive	passive	JJ
cord-269011-230p8rsf	441	4	immunization	immunization	NN
cord-269011-230p8rsf	441	5	of	of	IN
cord-269011-230p8rsf	441	6	mice	mouse	NNS
cord-269011-230p8rsf	441	7	with	with	IN
cord-269011-230p8rsf	441	8	nonneutralizing	nonneutralizing	NN
cord-269011-230p8rsf	441	9	,	,	,
cord-269011-230p8rsf	441	10	MHV	MHV	NNP
cord-269011-230p8rsf	441	11	HE	HE	NNP
cord-269011-230p8rsf	441	12	-	-	HYPH
cord-269011-230p8rsf	441	13	specific	specific	JJ
cord-269011-230p8rsf	441	14	antibodies	antibody	NNS
cord-269011-230p8rsf	441	15	protected	protect	VBD
cord-269011-230p8rsf	441	16	the	the	DT
cord-269011-230p8rsf	441	17	animals	animal	NNS
cord-269011-230p8rsf	441	18	against	against	IN
cord-269011-230p8rsf	441	19	a	a	DT
cord-269011-230p8rsf	441	20	lethal	lethal	JJ
cord-269011-230p8rsf	441	21	MHV	MHV	NNP
cord-269011-230p8rsf	441	22	infection	infection	NN
cord-269011-230p8rsf	442	1	(	(	-LRB-
cord-269011-230p8rsf	442	2	Yokomori	Yokomori	NNP
cord-269011-230p8rsf	442	3	et	et	FW
cord-269011-230p8rsf	442	4	al	al	NNP
cord-269011-230p8rsf	442	5	.	.	NNP
cord-269011-230p8rsf	442	6	,	,	,
cord-269011-230p8rsf	442	7	1992	1992	CD
cord-269011-230p8rsf	442	8	)	)	-RRB-
cord-269011-230p8rsf	442	9	.	.	.
cord-269011-230p8rsf	443	1	Furthermore	furthermore	RB
cord-269011-230p8rsf	443	2	,	,	,
cord-269011-230p8rsf	443	3	intracerebral	intracerebral	JJ
cord-269011-230p8rsf	443	4	expression	expression	NN
cord-269011-230p8rsf	443	5	of	of	IN
cord-269011-230p8rsf	443	6	the	the	DT
cord-269011-230p8rsf	443	7	HE	HE	NNP
cord-269011-230p8rsf	443	8	protein	protein	NN
cord-269011-230p8rsf	443	9	in	in	IN
cord-269011-230p8rsf	443	10	mice	mouse	NNS
cord-269011-230p8rsf	443	11	was	be	VBD
cord-269011-230p8rsf	443	12	found	find	VBN
cord-269011-230p8rsf	443	13	to	to	TO
cord-269011-230p8rsf	443	14	affect	affect	VB
cord-269011-230p8rsf	443	15	the	the	DT
cord-269011-230p8rsf	443	16	neuropathogenicity	neuropathogenicity	NN
cord-269011-230p8rsf	443	17	of	of	IN
cord-269011-230p8rsf	443	18	MHV	MHV	NNP
cord-269011-230p8rsf	444	1	(	(	-LRB-
cord-269011-230p8rsf	444	2	Yokomori	Yokomori	NNP
cord-269011-230p8rsf	444	3	et	et	FW
cord-269011-230p8rsf	444	4	al	al	NNP
cord-269011-230p8rsf	444	5	.	.	NNP
cord-269011-230p8rsf	444	6	,	,	,
cord-269011-230p8rsf	444	7	1995	1995	CD
cord-269011-230p8rsf	444	8	;	;	:
cord-269011-230p8rsf	444	9	Zhang	Zhang	NNP
cord-269011-230p8rsf	444	10	et	et	NNP
cord-269011-230p8rsf	444	11	al	al	NNP
cord-269011-230p8rsf	444	12	.	.	NNP
cord-269011-230p8rsf	444	13	,	,	,
cord-269011-230p8rsf	444	14	1998	1998	CD
cord-269011-230p8rsf	444	15	)	)	-RRB-
cord-269011-230p8rsf	444	16	.	.	.
cord-269011-230p8rsf	445	1	Strikingly	strikingly	RB
cord-269011-230p8rsf	445	2	,	,	,
cord-269011-230p8rsf	445	3	HE	HE	NNP
cord-269011-230p8rsf	445	4	protein	protein	NN
cord-269011-230p8rsf	445	5	-	-	HYPH
cord-269011-230p8rsf	445	6	defective	defective	JJ
cord-269011-230p8rsf	445	7	MHV	MHV	NNP
cord-269011-230p8rsf	445	8	mutants	mutant	NNS
cord-269011-230p8rsf	445	9	were	be	VBD
cord-269011-230p8rsf	445	10	rapidly	rapidly	RB
cord-269011-230p8rsf	445	11	selected	select	VBN
cord-269011-230p8rsf	445	12	during	during	IN
cord-269011-230p8rsf	445	13	viral	viral	JJ
cord-269011-230p8rsf	445	14	infection	infection	NN
cord-269011-230p8rsf	445	15	in	in	IN
cord-269011-230p8rsf	445	16	the	the	DT
cord-269011-230p8rsf	445	17	mouse	mouse	NN
cord-269011-230p8rsf	445	18	brain	brain	NN
cord-269011-230p8rsf	446	1	(	(	-LRB-
cord-269011-230p8rsf	446	2	Yokomori	Yokomori	NNP
cord-269011-230p8rsf	446	3	et	et	FW
cord-269011-230p8rsf	446	4	al	al	NNP
cord-269011-230p8rsf	446	5	.	.	NNP
cord-269011-230p8rsf	446	6	,	,	,
cord-269011-230p8rsf	446	7	1993	1993	CD
cord-269011-230p8rsf	446	8	)	)	-RRB-
cord-269011-230p8rsf	446	9	,	,	,
cord-269011-230p8rsf	446	10	which	which	WDT
cord-269011-230p8rsf	446	11	may	may	MD
cord-269011-230p8rsf	446	12	suggest	suggest	VB
cord-269011-230p8rsf	446	13	that	that	IN
cord-269011-230p8rsf	446	14	the	the	DT
cord-269011-230p8rsf	446	15	HE	HE	NNP
cord-269011-230p8rsf	446	16	protein	protein	NN
cord-269011-230p8rsf	446	17	plays	play	VBZ
cord-269011-230p8rsf	446	18	a	a	DT
cord-269011-230p8rsf	446	19	more	more	RBR
cord-269011-230p8rsf	446	20	critical	critical	JJ
cord-269011-230p8rsf	446	21	role	role	NN
cord-269011-230p8rsf	446	22	during	during	IN
cord-269011-230p8rsf	446	23	the	the	DT
cord-269011-230p8rsf	446	24	infection	infection	NN
cord-269011-230p8rsf	446	25	of	of	IN
cord-269011-230p8rsf	446	26	other	other	JJ
cord-269011-230p8rsf	446	27	tissues	tissue	NNS
cord-269011-230p8rsf	446	28	.	.	.
cord-269011-230p8rsf	447	1	Early	early	RB
cord-269011-230p8rsf	447	2	electron	electron	NN
cord-269011-230p8rsf	447	3	microscopic	microscopic	JJ
cord-269011-230p8rsf	447	4	studies	study	NNS
cord-269011-230p8rsf	447	5	demonstrated	demonstrate	VBD
cord-269011-230p8rsf	447	6	that	that	IN
cord-269011-230p8rsf	447	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	447	8	morphogenesis	morphogenesis	NN
cord-269011-230p8rsf	447	9	takes	take	VBZ
cord-269011-230p8rsf	447	10	place	place	NN
cord-269011-230p8rsf	447	11	at	at	IN
cord-269011-230p8rsf	447	12	intracellular	intracellular	JJ
cord-269011-230p8rsf	447	13	membranes	membrane	NNS
cord-269011-230p8rsf	447	14	and	and	CC
cord-269011-230p8rsf	447	15	identified	identify	VBD
cord-269011-230p8rsf	447	16	the	the	DT
cord-269011-230p8rsf	447	17	cisternae	cisternae	NN
cord-269011-230p8rsf	447	18	of	of	IN
cord-269011-230p8rsf	447	19	the	the	DT
cord-269011-230p8rsf	447	20	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	447	21	reticulum	reticulum	NN
cord-269011-230p8rsf	447	22	as	as	IN
cord-269011-230p8rsf	447	23	the	the	DT
cord-269011-230p8rsf	447	24	site	site	NN
cord-269011-230p8rsf	447	25	of	of	IN
cord-269011-230p8rsf	447	26	budding	bud	VBG
cord-269011-230p8rsf	447	27	of	of	IN
cord-269011-230p8rsf	447	28	IBV	IBV	NNP
cord-269011-230p8rsf	447	29	and	and	CC
cord-269011-230p8rsf	447	30	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	447	31	(	(	-LRB-
cord-269011-230p8rsf	447	32	Becker	Becker	NNP
cord-269011-230p8rsf	447	33	et	et	NNP
cord-269011-230p8rsf	447	34	al	al	NNP
cord-269011-230p8rsf	447	35	.	.	NNP
cord-269011-230p8rsf	447	36	,	,	,
cord-269011-230p8rsf	447	37	1967	1967	CD
cord-269011-230p8rsf	447	38	;	;	:
cord-269011-230p8rsf	447	39	Chasey	Chasey	NNP
cord-269011-230p8rsf	447	40	and	and	CC
cord-269011-230p8rsf	447	41	Alexander	Alexander	NNP
cord-269011-230p8rsf	447	42	,	,	,
cord-269011-230p8rsf	447	43	1976	1976	CD
cord-269011-230p8rsf	447	44	;	;	:
cord-269011-230p8rsf	447	45	Hamre	Hamre	NNP
cord-269011-230p8rsf	447	46	et	et	NNP
cord-269011-230p8rsf	447	47	al	al	NNP
cord-269011-230p8rsf	447	48	.	.	NNP
cord-269011-230p8rsf	447	49	,	,	,
cord-269011-230p8rsf	447	50	1967	1967	CD
cord-269011-230p8rsf	447	51	;	;	:
cord-269011-230p8rsf	447	52	Oshiro	Oshiro	NNP
cord-269011-230p8rsf	447	53	et	et	NNP
cord-269011-230p8rsf	447	54	al	al	NNP
cord-269011-230p8rsf	447	55	.	.	NNP
cord-269011-230p8rsf	447	56	,	,	,
cord-269011-230p8rsf	447	57	1971	1971	CD
cord-269011-230p8rsf	447	58	)	)	-RRB-
cord-269011-230p8rsf	447	59	.	.	.
cord-269011-230p8rsf	448	1	Later	Later	NNP
cord-269011-230p8rsf	448	2	studies	study	NNS
cord-269011-230p8rsf	448	3	revealed	reveal	VBD
cord-269011-230p8rsf	448	4	that	that	IN
cord-269011-230p8rsf	448	5	early	early	RB
cord-269011-230p8rsf	448	6	in	in	IN
cord-269011-230p8rsf	448	7	infection	infection	NN
cord-269011-230p8rsf	448	8	particle	particle	NN
cord-269011-230p8rsf	448	9	formation	formation	NN
cord-269011-230p8rsf	448	10	occurs	occur	VBZ
cord-269011-230p8rsf	448	11	predominantly	predominantly	RB
cord-269011-230p8rsf	448	12	at	at	IN
cord-269011-230p8rsf	448	13	smoothwalled	smoothwalled	NNP
cord-269011-230p8rsf	448	14	,	,	,
cord-269011-230p8rsf	448	15	tubulovesicular	tubulovesicular	NNP
cord-269011-230p8rsf	448	16	membranes	membrane	NNS
cord-269011-230p8rsf	448	17	located	locate	VBN
cord-269011-230p8rsf	448	18	intermediately	intermediately	RB
cord-269011-230p8rsf	448	19	between	between	IN
cord-269011-230p8rsf	448	20	the	the	DT
cord-269011-230p8rsf	448	21	rough	rough	JJ
cord-269011-230p8rsf	448	22	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	448	23	reticulum	reticulum	NN
cord-269011-230p8rsf	448	24	and	and	CC
cord-269011-230p8rsf	448	25	the	the	DT
cord-269011-230p8rsf	448	26	Golgi	Golgi	NNP
cord-269011-230p8rsf	448	27	complex	complex	NN
cord-269011-230p8rsf	448	28	(	(	-LRB-
cord-269011-230p8rsf	448	29	ERGIC	ERGIC	NNP
cord-269011-230p8rsf	448	30	)	)	-RRB-
cord-269011-230p8rsf	448	31	.	.	.
cord-269011-230p8rsf	449	1	This	this	DT
cord-269011-230p8rsf	449	2	so	so	RB
cord-269011-230p8rsf	449	3	-	-	HYPH
cord-269011-230p8rsf	449	4	called	call	VBN
cord-269011-230p8rsf	449	5	intermediate	intermediate	JJ
cord-269011-230p8rsf	449	6	compartment	compartment	NN
cord-269011-230p8rsf	449	7	was	be	VBD
cord-269011-230p8rsf	449	8	shown	show	VBN
cord-269011-230p8rsf	449	9	to	to	TO
cord-269011-230p8rsf	449	10	be	be	VB
cord-269011-230p8rsf	449	11	used	use	VBN
cord-269011-230p8rsf	449	12	as	as	IN
cord-269011-230p8rsf	449	13	the	the	DT
cord-269011-230p8rsf	449	14	early	early	JJ
cord-269011-230p8rsf	449	15	budding	bud	VBG
cord-269011-230p8rsf	449	16	compartment	compartment	NN
cord-269011-230p8rsf	449	17	by	by	IN
cord-269011-230p8rsf	449	18	MHV	MHV	NNP
cord-269011-230p8rsf	449	19	,	,	,
cord-269011-230p8rsf	449	20	IBV	IBV	NNP
cord-269011-230p8rsf	449	21	,	,	,
cord-269011-230p8rsf	449	22	FIPV	FIPV	NNP
cord-269011-230p8rsf	449	23	,	,	,
cord-269011-230p8rsf	449	24	TGEV	TGEV	NNP
cord-269011-230p8rsf	449	25	,	,	,
cord-269011-230p8rsf	449	26	and	and	CC
cord-269011-230p8rsf	449	27	SARS	SARS	NNP
cord-269011-230p8rsf	449	28	-	-	HYPH
cord-269011-230p8rsf	449	29	CoV	CoV	NNP
cord-269011-230p8rsf	449	30	(	(	-LRB-
cord-269011-230p8rsf	449	31	Goldsmith	Goldsmith	NNP
cord-269011-230p8rsf	449	32	et	et	NNP
cord-269011-230p8rsf	449	33	al	al	NNP
cord-269011-230p8rsf	449	34	.	.	NNP
cord-269011-230p8rsf	449	35	,	,	,
cord-269011-230p8rsf	449	36	2004	2004	CD
cord-269011-230p8rsf	449	37	;	;	:
cord-269011-230p8rsf	449	38	Klumperman	Klumperman	NNP
cord-269011-230p8rsf	449	39	et	et	FW
cord-269011-230p8rsf	449	40	al	al	NNP
cord-269011-230p8rsf	449	41	.	.	NNP
cord-269011-230p8rsf	449	42	,	,	,
cord-269011-230p8rsf	449	43	1994	1994	CD
cord-269011-230p8rsf	449	44	;	;	:
cord-269011-230p8rsf	449	45	Tooze	Tooze	NNP
cord-269011-230p8rsf	449	46	et	et	NNP
cord-269011-230p8rsf	449	47	al	al	NNP
cord-269011-230p8rsf	449	48	.	.	NNP
cord-269011-230p8rsf	449	49	,	,	,
cord-269011-230p8rsf	449	50	1984	1984	CD
cord-269011-230p8rsf	449	51	)	)	-RRB-
cord-269011-230p8rsf	449	52	.	.	.
cord-269011-230p8rsf	450	1	At	at	IN
cord-269011-230p8rsf	450	2	later	later	JJ
cord-269011-230p8rsf	450	3	times	time	NNS
cord-269011-230p8rsf	450	4	during	during	IN
cord-269011-230p8rsf	450	5	infection	infection	NN
cord-269011-230p8rsf	450	6	the	the	DT
cord-269011-230p8rsf	450	7	rough	rough	JJ
cord-269011-230p8rsf	450	8	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	450	9	reticulum	reticulum	NN
cord-269011-230p8rsf	450	10	was	be	VBD
cord-269011-230p8rsf	450	11	seen	see	VBN
cord-269011-230p8rsf	450	12	to	to	TO
cord-269011-230p8rsf	450	13	gradually	gradually	RB
cord-269011-230p8rsf	450	14	become	become	VB
cord-269011-230p8rsf	450	15	the	the	DT
cord-269011-230p8rsf	450	16	major	major	JJ
cord-269011-230p8rsf	450	17	site	site	NN
cord-269011-230p8rsf	450	18	of	of	IN
cord-269011-230p8rsf	450	19	MHV	MHV	NNP
cord-269011-230p8rsf	450	20	budding	bud	VBG
cord-269011-230p8rsf	450	21	in	in	IN
cord-269011-230p8rsf	450	22	fibroblasts	fibroblast	NNS
cord-269011-230p8rsf	450	23	(	(	-LRB-
cord-269011-230p8rsf	450	24	Tooze	Tooze	NNP
cord-269011-230p8rsf	450	25	et	et	NNP
cord-269011-230p8rsf	450	26	al	al	NNP
cord-269011-230p8rsf	450	27	.	.	NNP
cord-269011-230p8rsf	450	28	,	,	,
cord-269011-230p8rsf	450	29	1984	1984	CD
cord-269011-230p8rsf	450	30	)	)	-RRB-
cord-269011-230p8rsf	450	31	.	.	.
cord-269011-230p8rsf	451	1	As	as	IN
cord-269011-230p8rsf	451	2	already	already	RB
cord-269011-230p8rsf	451	3	mentioned	mention	VBN
cord-269011-230p8rsf	451	4	,	,	,
cord-269011-230p8rsf	451	5	ultrastructural	ultrastructural	JJ
cord-269011-230p8rsf	451	6	studies	study	NNS
cord-269011-230p8rsf	451	7	localized	localize	VBD
cord-269011-230p8rsf	451	8	the	the	DT
cord-269011-230p8rsf	451	9	MHV	MHV	NNP
cord-269011-230p8rsf	451	10	and	and	CC
cord-269011-230p8rsf	451	11	IBV	IBV	NNP
cord-269011-230p8rsf	451	12	M	M	NNP
cord-269011-230p8rsf	451	13	proteins	protein	NNS
cord-269011-230p8rsf	451	14	in	in	IN
cord-269011-230p8rsf	451	15	the	the	DT
cord-269011-230p8rsf	451	16	budding	bud	VBG
cord-269011-230p8rsf	451	17	compartment(s	compartment(s	NNP
cord-269011-230p8rsf	451	18	)	)	-RRB-
cord-269011-230p8rsf	452	1	but	but	CC
cord-269011-230p8rsf	452	2	also	also	RB
cord-269011-230p8rsf	452	3	in	in	IN
cord-269011-230p8rsf	452	4	the	the	DT
cord-269011-230p8rsf	452	5	Golgi	Golgi	NNP
cord-269011-230p8rsf	452	6	complex	complex	NN
cord-269011-230p8rsf	452	7	,	,	,
cord-269011-230p8rsf	452	8	that	that	RB
cord-269011-230p8rsf	452	9	is	is	RB
cord-269011-230p8rsf	452	10	,	,	,
cord-269011-230p8rsf	452	11	beyond	beyond	IN
cord-269011-230p8rsf	452	12	the	the	DT
cord-269011-230p8rsf	452	13	site	site	NN
cord-269011-230p8rsf	452	14	of	of	IN
cord-269011-230p8rsf	452	15	budding	bud	VBG
cord-269011-230p8rsf	452	16	Tooze	Tooze	NNP
cord-269011-230p8rsf	452	17	et	et	NNP
cord-269011-230p8rsf	452	18	al	al	NNP
cord-269011-230p8rsf	452	19	.	.	NNP
cord-269011-230p8rsf	452	20	,	,	,
cord-269011-230p8rsf	452	21	1984	1984	CD
cord-269011-230p8rsf	452	22	)	)	-RRB-
cord-269011-230p8rsf	452	23	.	.	.
cord-269011-230p8rsf	453	1	Apparently	apparently	RB
cord-269011-230p8rsf	453	2	,	,	,
cord-269011-230p8rsf	453	3	accumulation	accumulation	NN
cord-269011-230p8rsf	453	4	of	of	IN
cord-269011-230p8rsf	453	5	M	M	NNP
cord-269011-230p8rsf	453	6	protein	protein	NN
cord-269011-230p8rsf	453	7	alone	alone	RB
cord-269011-230p8rsf	453	8	is	be	VBZ
cord-269011-230p8rsf	453	9	not	not	RB
cord-269011-230p8rsf	453	10	sufficient	sufficient	JJ
cord-269011-230p8rsf	453	11	to	to	TO
cord-269011-230p8rsf	453	12	determine	determine	VB
cord-269011-230p8rsf	453	13	the	the	DT
cord-269011-230p8rsf	453	14	site	site	NN
cord-269011-230p8rsf	453	15	of	of	IN
cord-269011-230p8rsf	453	16	budding	bud	VBG
cord-269011-230p8rsf	453	17	;	;	:
cord-269011-230p8rsf	453	18	other	other	JJ
cord-269011-230p8rsf	453	19	viral	viral	NN
cord-269011-230p8rsf	453	20	and/or	and/or	CC
cord-269011-230p8rsf	453	21	cellular	cellular	JJ
cord-269011-230p8rsf	453	22	factors	factor	NNS
cord-269011-230p8rsf	453	23	are	be	VBP
cord-269011-230p8rsf	453	24	required	require	VBN
cord-269011-230p8rsf	453	25	as	as	RB
cord-269011-230p8rsf	453	26	well	well	RB
cord-269011-230p8rsf	453	27	.	.	.
cord-269011-230p8rsf	454	1	For	for	IN
cord-269011-230p8rsf	454	2	MHV	MHV	NNP
cord-269011-230p8rsf	454	3	the	the	DT
cord-269011-230p8rsf	454	4	E	e	NN
cord-269011-230p8rsf	454	5	protein	protein	NN
cord-269011-230p8rsf	454	6	,	,	,
cord-269011-230p8rsf	454	7	which	which	WDT
cord-269011-230p8rsf	454	8	was	be	VBD
cord-269011-230p8rsf	454	9	found	find	VBN
cord-269011-230p8rsf	454	10	to	to	TO
cord-269011-230p8rsf	454	11	localize	localize	VB
cord-269011-230p8rsf	454	12	to	to	IN
cord-269011-230p8rsf	454	13	the	the	DT
cord-269011-230p8rsf	454	14	intermediate	intermediate	JJ
cord-269011-230p8rsf	454	15	compartment	compartment	NN
cord-269011-230p8rsf	454	16	by	by	IN
cord-269011-230p8rsf	454	17	immunoelectron	immunoelectron	NNP
cord-269011-230p8rsf	454	18	microscopy	microscopy	NNP
cord-269011-230p8rsf	454	19	(	(	-LRB-
cord-269011-230p8rsf	454	20	immuno	immuno	JJ
cord-269011-230p8rsf	454	21	-	-	HYPH
cord-269011-230p8rsf	454	22	EM	EM	NNP
cord-269011-230p8rsf	454	23	)	)	-RRB-
cord-269011-230p8rsf	454	24	,	,	,
cord-269011-230p8rsf	454	25	was	be	VBD
cord-269011-230p8rsf	454	26	suggested	suggest	VBN
cord-269011-230p8rsf	454	27	to	to	TO
cord-269011-230p8rsf	454	28	be	be	VB
cord-269011-230p8rsf	454	29	such	such	PDT
cord-269011-230p8rsf	454	30	a	a	DT
cord-269011-230p8rsf	454	31	candidate	candidate	NN
cord-269011-230p8rsf	454	32	,	,	,
cord-269011-230p8rsf	454	33	but	but	CC
cord-269011-230p8rsf	454	34	more	more	JJR
cord-269011-230p8rsf	454	35	players	player	NNS
cord-269011-230p8rsf	454	36	are	be	VBP
cord-269011-230p8rsf	454	37	likely	likely	JJ
cord-269011-230p8rsf	454	38	to	to	TO
cord-269011-230p8rsf	454	39	be	be	VB
cord-269011-230p8rsf	454	40	involved	involve	VBN
cord-269011-230p8rsf	454	41	.	.	.
cord-269011-230p8rsf	455	1	Whether	whether	IN
cord-269011-230p8rsf	455	2	the	the	DT
cord-269011-230p8rsf	455	3	helical	helical	JJ
cord-269011-230p8rsf	455	4	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	455	5	,	,	,
cord-269011-230p8rsf	455	6	visible	visible	JJ
cord-269011-230p8rsf	455	7	as	as	IN
cord-269011-230p8rsf	455	8	electron	electron	NN
cord-269011-230p8rsf	455	9	-	-	HYPH
cord-269011-230p8rsf	455	10	dense	dense	JJ
cord-269011-230p8rsf	455	11	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	455	12	elements	element	NNS
cord-269011-230p8rsf	455	13	adjacent	adjacent	JJ
cord-269011-230p8rsf	455	14	to	to	IN
cord-269011-230p8rsf	455	15	budding	bud	VBG
cord-269011-230p8rsf	455	16	profiles	profile	NNS
cord-269011-230p8rsf	455	17	(	(	-LRB-
cord-269011-230p8rsf	455	18	David	David	NNP
cord-269011-230p8rsf	455	19	-	-	HYPH
cord-269011-230p8rsf	455	20	Ferreira	Ferreira	NNP
cord-269011-230p8rsf	455	21	and	and	CC
cord-269011-230p8rsf	455	22	Manaker	Manaker	NNP
cord-269011-230p8rsf	455	23	,	,	,
cord-269011-230p8rsf	455	24	1965	1965	CD
cord-269011-230p8rsf	455	25	;	;	:
cord-269011-230p8rsf	455	26	Dubois	Dubois	NNP
cord-269011-230p8rsf	455	27	-	-	HYPH
cord-269011-230p8rsf	455	28	Dalcq	Dalcq	NNP
cord-269011-230p8rsf	455	29	et	et	NNP
cord-269011-230p8rsf	455	30	al	al	NNP
cord-269011-230p8rsf	455	31	.	.	NNP
cord-269011-230p8rsf	455	32	,	,	,
cord-269011-230p8rsf	455	33	1982	1982	CD
cord-269011-230p8rsf	455	34	;	;	:
cord-269011-230p8rsf	455	35	Massalski	Massalski	NNP
cord-269011-230p8rsf	455	36	et	et	NNP
cord-269011-230p8rsf	455	37	al	al	NNP
cord-269011-230p8rsf	455	38	.	.	NNP
cord-269011-230p8rsf	455	39	,	,	,
cord-269011-230p8rsf	455	40	1982	1982	CD
cord-269011-230p8rsf	455	41	;	;	:
cord-269011-230p8rsf	455	42	Risco	Risco	NNP
cord-269011-230p8rsf	455	43	et	et	NNP
cord-269011-230p8rsf	455	44	al	al	NNP
cord-269011-230p8rsf	455	45	.	.	NNP
cord-269011-230p8rsf	455	46	,	,	,
cord-269011-230p8rsf	455	47	1998	1998	CD
cord-269011-230p8rsf	455	48	;	;	:
cord-269011-230p8rsf	455	49	and	and	CC
cord-269011-230p8rsf	455	50	references	reference	NNS
cord-269011-230p8rsf	455	51	given	give	VBN
cord-269011-230p8rsf	455	52	previously	previously	RB
cord-269011-230p8rsf	455	53	)	)	-RRB-
cord-269011-230p8rsf	455	54	,	,	,
cord-269011-230p8rsf	455	55	are	be	VBP
cord-269011-230p8rsf	455	56	a	a	DT
cord-269011-230p8rsf	455	57	determining	determine	VBG
cord-269011-230p8rsf	455	58	factor	factor	NN
cord-269011-230p8rsf	455	59	is	be	VBZ
cord-269011-230p8rsf	455	60	unclear	unclear	JJ
cord-269011-230p8rsf	455	61	.	.	.
cord-269011-230p8rsf	456	1	In	in	IN
cord-269011-230p8rsf	456	2	this	this	DT
cord-269011-230p8rsf	456	3	respect	respect	NN
cord-269011-230p8rsf	456	4	,	,	,
cord-269011-230p8rsf	456	5	knowledge	knowledge	NN
cord-269011-230p8rsf	456	6	about	about	IN
cord-269011-230p8rsf	456	7	the	the	DT
cord-269011-230p8rsf	456	8	budding	bud	VBG
cord-269011-230p8rsf	456	9	location	location	NN
cord-269011-230p8rsf	456	10	of	of	IN
cord-269011-230p8rsf	456	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	456	12	-	-	HYPH
cord-269011-230p8rsf	456	13	like	like	JJ
cord-269011-230p8rsf	456	14	particles	particle	NNS
cord-269011-230p8rsf	456	15	(	(	-LRB-
cord-269011-230p8rsf	456	16	see	see	VB
cord-269011-230p8rsf	456	17	later	later	RB
cord-269011-230p8rsf	456	18	)	)	-RRB-
cord-269011-230p8rsf	456	19	might	may	MD
cord-269011-230p8rsf	456	20	be	be	VB
cord-269011-230p8rsf	456	21	informative	informative	JJ
cord-269011-230p8rsf	456	22	.	.	.
cord-269011-230p8rsf	457	1	Coronavirions	coronavirion	NNS
cord-269011-230p8rsf	457	2	are	be	VBP
cord-269011-230p8rsf	457	3	subject	subject	JJ
cord-269011-230p8rsf	457	4	to	to	IN
cord-269011-230p8rsf	457	5	an	an	DT
cord-269011-230p8rsf	457	6	intracellular	intracellular	JJ
cord-269011-230p8rsf	457	7	postbudding	postbudding	NN
cord-269011-230p8rsf	457	8	maturation	maturation	NN
cord-269011-230p8rsf	457	9	process	process	NN
cord-269011-230p8rsf	457	10	that	that	WDT
cord-269011-230p8rsf	457	11	occurs	occur	VBZ
cord-269011-230p8rsf	457	12	while	while	IN
cord-269011-230p8rsf	457	13	they	-PRON-	PRP
cord-269011-230p8rsf	457	14	are	be	VBP
cord-269011-230p8rsf	457	15	on	on	IN
cord-269011-230p8rsf	457	16	their	-PRON-	PRP$
cord-269011-230p8rsf	457	17	way	way	NN
cord-269011-230p8rsf	457	18	through	through	IN
cord-269011-230p8rsf	457	19	the	the	DT
cord-269011-230p8rsf	457	20	constitutive	constitutive	JJ
cord-269011-230p8rsf	457	21	exocytic	exocytic	JJ
cord-269011-230p8rsf	457	22	pathway	pathway	NN
cord-269011-230p8rsf	457	23	by	by	IN
cord-269011-230p8rsf	457	24	which	which	WDT
cord-269011-230p8rsf	457	25	they	-PRON-	PRP
cord-269011-230p8rsf	457	26	are	be	VBP
cord-269011-230p8rsf	457	27	exported	export	VBN
cord-269011-230p8rsf	457	28	out	out	IN
cord-269011-230p8rsf	457	29	of	of	IN
cord-269011-230p8rsf	457	30	the	the	DT
cord-269011-230p8rsf	457	31	cell	cell	NN
cord-269011-230p8rsf	458	1	(	(	-LRB-
cord-269011-230p8rsf	458	2	Risco	Risco	NNP
cord-269011-230p8rsf	458	3	et	et	NNP
cord-269011-230p8rsf	458	4	al	al	NNP
cord-269011-230p8rsf	458	5	.	.	NNP
cord-269011-230p8rsf	458	6	,	,	,
cord-269011-230p8rsf	458	7	1998	1998	CD
cord-269011-230p8rsf	458	8	;	;	:
cord-269011-230p8rsf	458	9	Salanueva	Salanueva	NNP
cord-269011-230p8rsf	458	10	et	et	NNP
cord-269011-230p8rsf	458	11	al	al	NNP
cord-269011-230p8rsf	458	12	.	.	NNP
cord-269011-230p8rsf	458	13	,	,	,
cord-269011-230p8rsf	458	14	1999	1999	CD
cord-269011-230p8rsf	458	15	;	;	:
cord-269011-230p8rsf	459	1	Tooze	Tooze	NNP
cord-269011-230p8rsf	459	2	et	et	NNP
cord-269011-230p8rsf	459	3	al	al	NNP
cord-269011-230p8rsf	459	4	.	.	NNP
cord-269011-230p8rsf	459	5	,	,	,
cord-269011-230p8rsf	459	6	1987	1987	CD
cord-269011-230p8rsf	459	7	)	)	-RRB-
cord-269011-230p8rsf	459	8	.	.	.
cord-269011-230p8rsf	460	1	Indications	indication	NNS
cord-269011-230p8rsf	460	2	of	of	IN
cord-269011-230p8rsf	460	3	this	this	DT
cord-269011-230p8rsf	460	4	had	have	VBD
cord-269011-230p8rsf	460	5	already	already	RB
cord-269011-230p8rsf	460	6	been	be	VBN
cord-269011-230p8rsf	460	7	noticed	notice	VBN
cord-269011-230p8rsf	460	8	in	in	IN
cord-269011-230p8rsf	460	9	early	early	JJ
cord-269011-230p8rsf	460	10	morphological	morphological	JJ
cord-269011-230p8rsf	460	11	studies	study	NNS
cord-269011-230p8rsf	460	12	with	with	IN
cord-269011-230p8rsf	460	13	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	460	14	(	(	-LRB-
cord-269011-230p8rsf	460	15	Becker	Becker	NNP
cord-269011-230p8rsf	460	16	et	et	NNP
cord-269011-230p8rsf	460	17	al	al	NNP
cord-269011-230p8rsf	460	18	.	.	NNP
cord-269011-230p8rsf	460	19	,	,	,
cord-269011-230p8rsf	460	20	1967	1967	CD
cord-269011-230p8rsf	460	21	;	;	:
cord-269011-230p8rsf	460	22	Chasey	Chasey	NNP
cord-269011-230p8rsf	460	23	and	and	CC
cord-269011-230p8rsf	460	24	Alexander	Alexander	NNP
cord-269011-230p8rsf	460	25	,	,	,
cord-269011-230p8rsf	460	26	1976	1976	CD
cord-269011-230p8rsf	460	27	;	;	:
cord-269011-230p8rsf	460	28	Hamre	Hamre	NNP
cord-269011-230p8rsf	460	29	et	et	NNP
cord-269011-230p8rsf	460	30	al	al	NNP
cord-269011-230p8rsf	460	31	.	.	NNP
cord-269011-230p8rsf	460	32	,	,	,
cord-269011-230p8rsf	460	33	1967	1967	CD
cord-269011-230p8rsf	460	34	;	;	:
cord-269011-230p8rsf	460	35	Oshiro	Oshiro	NNP
cord-269011-230p8rsf	460	36	et	et	NNP
cord-269011-230p8rsf	460	37	al	al	NNP
cord-269011-230p8rsf	460	38	.	.	NNP
cord-269011-230p8rsf	460	39	,	,	,
cord-269011-230p8rsf	460	40	1971	1971	CD
cord-269011-230p8rsf	460	41	)	)	-RRB-
cord-269011-230p8rsf	460	42	and	and	CC
cord-269011-230p8rsf	460	43	MHV	MHV	NNP
cord-269011-230p8rsf	460	44	(	(	-LRB-
cord-269011-230p8rsf	460	45	Holmes	Holmes	NNP
cord-269011-230p8rsf	460	46	and	and	CC
cord-269011-230p8rsf	460	47	Behnke	Behnke	NNP
cord-269011-230p8rsf	460	48	,	,	,
cord-269011-230p8rsf	460	49	1981	1981	CD
cord-269011-230p8rsf	460	50	;	;	:
cord-269011-230p8rsf	460	51	,	,	,
cord-269011-230p8rsf	460	52	but	but	CC
cord-269011-230p8rsf	460	53	were	be	VBD
cord-269011-230p8rsf	460	54	described	describe	VBN
cord-269011-230p8rsf	460	55	in	in	IN
cord-269011-230p8rsf	460	56	somewhat	somewhat	RB
cord-269011-230p8rsf	460	57	more	more	JJR
cord-269011-230p8rsf	460	58	detail	detail	NN
cord-269011-230p8rsf	460	59	for	for	IN
cord-269011-230p8rsf	460	60	MHV	MHV	NNP
cord-269011-230p8rsf	460	61	by	by	IN
cord-269011-230p8rsf	460	62	Tooze	Tooze	NNP
cord-269011-230p8rsf	460	63	and	and	CC
cord-269011-230p8rsf	460	64	coworkers	coworker	NNS
cord-269011-230p8rsf	460	65	(	(	-LRB-
cord-269011-230p8rsf	460	66	1987	1987	CD
cord-269011-230p8rsf	460	67	)	)	-RRB-
cord-269011-230p8rsf	460	68	.	.	.
cord-269011-230p8rsf	461	1	The	the	DT
cord-269011-230p8rsf	461	2	pictures	picture	NNS
cord-269011-230p8rsf	461	3	show	show	VBP
cord-269011-230p8rsf	461	4	"	"	``
cord-269011-230p8rsf	461	5	immature	immature	JJ
cord-269011-230p8rsf	461	6	"	"	''
cord-269011-230p8rsf	461	7	virions	virion	NNS
cord-269011-230p8rsf	461	8	in	in	IN
cord-269011-230p8rsf	461	9	pre	pre	JJ
cord-269011-230p8rsf	461	10	-	-	JJ
cord-269011-230p8rsf	461	11	Golgi	golgi	JJ
cord-269011-230p8rsf	461	12	compartments	compartment	NNS
cord-269011-230p8rsf	461	13	and	and	CC
cord-269011-230p8rsf	461	14	Golgi	Golgi	NNP
cord-269011-230p8rsf	461	15	cisternae	cisternae	NNP
cord-269011-230p8rsf	461	16	that	that	WDT
cord-269011-230p8rsf	461	17	appear	appear	VBP
cord-269011-230p8rsf	461	18	as	as	IN
cord-269011-230p8rsf	461	19	spherical	spherical	JJ
cord-269011-230p8rsf	461	20	structures	structure	NNS
cord-269011-230p8rsf	461	21	with	with	IN
cord-269011-230p8rsf	461	22	the	the	DT
cord-269011-230p8rsf	461	23	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	461	24	core	core	NN
cord-269011-230p8rsf	461	25	immediately	immediately	RB
cord-269011-230p8rsf	461	26	below	below	IN
cord-269011-230p8rsf	461	27	the	the	DT
cord-269011-230p8rsf	461	28	viral	viral	JJ
cord-269011-230p8rsf	461	29	envelope	envelope	NN
cord-269011-230p8rsf	461	30	and	and	CC
cord-269011-230p8rsf	461	31	with	with	IN
cord-269011-230p8rsf	461	32	an	an	DT
cord-269011-230p8rsf	461	33	"	"	``
cord-269011-230p8rsf	461	34	empty	empty	JJ
cord-269011-230p8rsf	461	35	"	"	''
cord-269011-230p8rsf	461	36	center	center	NN
cord-269011-230p8rsf	461	37	.	.	.
cord-269011-230p8rsf	462	1	By	by	IN
cord-269011-230p8rsf	462	2	contrast	contrast	NN
cord-269011-230p8rsf	462	3	,	,	,
cord-269011-230p8rsf	462	4	virions	virion	NNS
cord-269011-230p8rsf	462	5	in	in	IN
cord-269011-230p8rsf	462	6	the	the	DT
cord-269011-230p8rsf	462	7	trans	trans	NNP
cord-269011-230p8rsf	462	8	-	-	NNP
cord-269011-230p8rsf	462	9	Golgi	Golgi	NNP
cord-269011-230p8rsf	462	10	network	network	NN
cord-269011-230p8rsf	462	11	and	and	CC
cord-269011-230p8rsf	462	12	beyond	beyond	IN
cord-269011-230p8rsf	462	13	have	have	VBP
cord-269011-230p8rsf	462	14	the	the	DT
cord-269011-230p8rsf	462	15	mature	mature	JJ
cord-269011-230p8rsf	462	16	morphology	morphology	NN
cord-269011-230p8rsf	462	17	showing	show	VBG
cord-269011-230p8rsf	462	18	a	a	DT
cord-269011-230p8rsf	462	19	fairly	fairly	RB
cord-269011-230p8rsf	462	20	uniform	uniform	JJ
cord-269011-230p8rsf	462	21	,	,	,
cord-269011-230p8rsf	462	22	high	high	JJ
cord-269011-230p8rsf	462	23	internal	internal	JJ
cord-269011-230p8rsf	462	24	electron	electron	NN
cord-269011-230p8rsf	462	25	density	density	NN
cord-269011-230p8rsf	462	26	.	.	.
cord-269011-230p8rsf	463	1	An	an	DT
cord-269011-230p8rsf	463	2	extensive	extensive	JJ
cord-269011-230p8rsf	463	3	analysis	analysis	NN
cord-269011-230p8rsf	463	4	of	of	IN
cord-269011-230p8rsf	463	5	the	the	DT
cord-269011-230p8rsf	463	6	structural	structural	JJ
cord-269011-230p8rsf	463	7	maturation	maturation	NN
cord-269011-230p8rsf	463	8	of	of	IN
cord-269011-230p8rsf	463	9	coronavirions	coronavirion	NNS
cord-269011-230p8rsf	463	10	was	be	VBD
cord-269011-230p8rsf	463	11	reported	report	VBN
cord-269011-230p8rsf	463	12	for	for	IN
cord-269011-230p8rsf	463	13	TGEV	TGEV	NNP
cord-269011-230p8rsf	463	14	(	(	-LRB-
cord-269011-230p8rsf	463	15	Risco	Risco	NNP
cord-269011-230p8rsf	463	16	et	et	NNP
cord-269011-230p8rsf	463	17	al	al	NNP
cord-269011-230p8rsf	463	18	.	.	NNP
cord-269011-230p8rsf	463	19	,	,	,
cord-269011-230p8rsf	463	20	1998	1998	CD
cord-269011-230p8rsf	463	21	;	;	:
cord-269011-230p8rsf	464	1	Salanueva	Salanueva	NNP
cord-269011-230p8rsf	464	2	et	et	NNP
cord-269011-230p8rsf	464	3	al	al	NNP
cord-269011-230p8rsf	464	4	.	.	NNP
cord-269011-230p8rsf	464	5	,	,	,
cord-269011-230p8rsf	464	6	1999	1999	CD
cord-269011-230p8rsf	464	7	)	)	-RRB-
cord-269011-230p8rsf	464	8	.	.	.
cord-269011-230p8rsf	465	1	Budding	bud	VBG
cord-269011-230p8rsf	465	2	was	be	VBD
cord-269011-230p8rsf	465	3	shown	show	VBN
cord-269011-230p8rsf	465	4	to	to	TO
cord-269011-230p8rsf	465	5	yield	yield	VB
cord-269011-230p8rsf	465	6	relatively	relatively	RB
cord-269011-230p8rsf	465	7	large	large	JJ
cord-269011-230p8rsf	465	8	virions	virion	NNS
cord-269011-230p8rsf	465	9	with	with	IN
cord-269011-230p8rsf	465	10	an	an	DT
cord-269011-230p8rsf	465	11	annular	annular	NN
cord-269011-230p8rsf	465	12	,	,	,
cord-269011-230p8rsf	465	13	electron	electron	NN
cord-269011-230p8rsf	465	14	-	-	HYPH
cord-269011-230p8rsf	465	15	dense	dense	JJ
cord-269011-230p8rsf	465	16	internal	internal	JJ
cord-269011-230p8rsf	465	17	periphery	periphery	NN
cord-269011-230p8rsf	465	18	and	and	CC
cord-269011-230p8rsf	465	19	a	a	DT
cord-269011-230p8rsf	465	20	clear	clear	JJ
cord-269011-230p8rsf	465	21	central	central	JJ
cord-269011-230p8rsf	465	22	area	area	NN
cord-269011-230p8rsf	465	23	.	.	.
cord-269011-230p8rsf	466	1	Smaller	small	JJR
cord-269011-230p8rsf	466	2	particles	particle	NNS
cord-269011-230p8rsf	466	3	,	,	,
cord-269011-230p8rsf	466	4	with	with	IN
cord-269011-230p8rsf	466	5	the	the	DT
cord-269011-230p8rsf	466	6	characteristic	characteristic	JJ
cord-269011-230p8rsf	466	7	morphology	morphology	NN
cord-269011-230p8rsf	466	8	of	of	IN
cord-269011-230p8rsf	466	9	extracellular	extracellular	JJ
cord-269011-230p8rsf	466	10	virions	virion	NNS
cord-269011-230p8rsf	466	11	,	,	,
cord-269011-230p8rsf	466	12	that	that	RB
cord-269011-230p8rsf	466	13	is	is	RB
cord-269011-230p8rsf	466	14	,	,	,
cord-269011-230p8rsf	466	15	having	have	VBG
cord-269011-230p8rsf	466	16	a	a	DT
cord-269011-230p8rsf	466	17	compact	compact	JJ
cord-269011-230p8rsf	466	18	,	,	,
cord-269011-230p8rsf	466	19	dense	dense	JJ
cord-269011-230p8rsf	466	20	inner	inner	JJ
cord-269011-230p8rsf	466	21	core	core	NN
cord-269011-230p8rsf	466	22	with	with	IN
cord-269011-230p8rsf	466	23	polygonal	polygonal	JJ
cord-269011-230p8rsf	466	24	contours	contour	NNS
cord-269011-230p8rsf	466	25	,	,	,
cord-269011-230p8rsf	466	26	were	be	VBD
cord-269011-230p8rsf	466	27	seen	see	VBN
cord-269011-230p8rsf	466	28	to	to	TO
cord-269011-230p8rsf	466	29	accumulate	accumulate	VB
cord-269011-230p8rsf	466	30	in	in	IN
cord-269011-230p8rsf	466	31	secretory	secretory	JJ
cord-269011-230p8rsf	466	32	vesicles	vesicle	NNS
cord-269011-230p8rsf	466	33	in	in	IN
cord-269011-230p8rsf	466	34	the	the	DT
cord-269011-230p8rsf	466	35	periphery	periphery	NN
cord-269011-230p8rsf	466	36	of	of	IN
cord-269011-230p8rsf	466	37	the	the	DT
cord-269011-230p8rsf	466	38	infected	infected	JJ
cord-269011-230p8rsf	466	39	cell	cell	NN
cord-269011-230p8rsf	466	40	.	.	.
cord-269011-230p8rsf	467	1	Both	both	DT
cord-269011-230p8rsf	467	2	types	type	NNS
cord-269011-230p8rsf	467	3	of	of	IN
cord-269011-230p8rsf	467	4	particles	particle	NNS
cord-269011-230p8rsf	467	5	appeared	appear	VBD
cord-269011-230p8rsf	467	6	to	to	TO
cord-269011-230p8rsf	467	7	coexist	coexist	VB
cord-269011-230p8rsf	467	8	in	in	IN
cord-269011-230p8rsf	467	9	the	the	DT
cord-269011-230p8rsf	467	10	Golgi	Golgi	NNP
cord-269011-230p8rsf	467	11	complex	complex	NN
cord-269011-230p8rsf	467	12	(	(	-LRB-
cord-269011-230p8rsf	467	13	Fig	fig	NN
cord-269011-230p8rsf	467	14	.	.	.
cord-269011-230p8rsf	467	15	5	5	CD
cord-269011-230p8rsf	467	16	)	)	-RRB-
cord-269011-230p8rsf	467	17	.	.	.
cord-269011-230p8rsf	468	1	Obviously	obviously	RB
cord-269011-230p8rsf	468	2	,	,	,
cord-269011-230p8rsf	468	3	the	the	DT
cord-269011-230p8rsf	468	4	larger	large	JJR
cord-269011-230p8rsf	468	5	particles	particle	NNS
cord-269011-230p8rsf	468	6	are	be	VBP
cord-269011-230p8rsf	468	7	the	the	DT
cord-269011-230p8rsf	468	8	precursors	precursor	NNS
cord-269011-230p8rsf	468	9	of	of	IN
cord-269011-230p8rsf	468	10	the	the	DT
cord-269011-230p8rsf	468	11	smaller	small	JJR
cord-269011-230p8rsf	468	12	mature	mature	JJ
cord-269011-230p8rsf	468	13	virions	virion	NNS
cord-269011-230p8rsf	468	14	(	(	-LRB-
cord-269011-230p8rsf	468	15	Salanueva	Salanueva	NNP
cord-269011-230p8rsf	468	16	et	et	NNP
cord-269011-230p8rsf	468	17	al	al	NNP
cord-269011-230p8rsf	468	18	.	.	NNP
cord-269011-230p8rsf	468	19	,	,	,
cord-269011-230p8rsf	468	20	1999	1999	CD
cord-269011-230p8rsf	468	21	)	)	-RRB-
cord-269011-230p8rsf	468	22	and	and	CC
cord-269011-230p8rsf	468	23	probably	probably	RB
cord-269011-230p8rsf	468	24	undergo	undergo	VB
cord-269011-230p8rsf	468	25	their	-PRON-	PRP$
cord-269011-230p8rsf	468	26	morphological	morphological	JJ
cord-269011-230p8rsf	468	27	maturation	maturation	NN
cord-269011-230p8rsf	468	28	during	during	IN
cord-269011-230p8rsf	468	29	their	-PRON-	PRP$
cord-269011-230p8rsf	468	30	transport	transport	NN
cord-269011-230p8rsf	468	31	through	through	IN
cord-269011-230p8rsf	468	32	the	the	DT
cord-269011-230p8rsf	468	33	Golgi	Golgi	NNP
cord-269011-230p8rsf	468	34	complex	complex	NN
cord-269011-230p8rsf	468	35	.	.	.
cord-269011-230p8rsf	469	1	The	the	DT
cord-269011-230p8rsf	469	2	reorganization	reorganization	NN
cord-269011-230p8rsf	469	3	of	of	IN
cord-269011-230p8rsf	469	4	the	the	DT
cord-269011-230p8rsf	469	5	particle	particle	NN
cord-269011-230p8rsf	469	6	gives	give	VBZ
cord-269011-230p8rsf	469	7	rise	rise	NN
cord-269011-230p8rsf	469	8	to	to	IN
cord-269011-230p8rsf	469	9	the	the	DT
cord-269011-230p8rsf	469	10	supposedly	supposedly	RB
cord-269011-230p8rsf	469	11	icosahedral	icosahedral	JJ
cord-269011-230p8rsf	469	12	core	core	NN
cord-269011-230p8rsf	469	13	shell	shell	NN
cord-269011-230p8rsf	469	14	and	and	CC
cord-269011-230p8rsf	469	15	is	be	VBZ
cord-269011-230p8rsf	469	16	accompanied	accompany	VBN
cord-269011-230p8rsf	469	17	by	by	IN
cord-269011-230p8rsf	469	18	a	a	DT
cord-269011-230p8rsf	469	19	dramatic	dramatic	JJ
cord-269011-230p8rsf	469	20	,	,	,
cord-269011-230p8rsf	469	21	approximately	approximately	RB
cord-269011-230p8rsf	469	22	50	50	CD
cord-269011-230p8rsf	469	23	%	%	NN
cord-269011-230p8rsf	469	24	reduction	reduction	NN
cord-269011-230p8rsf	469	25	of	of	IN
cord-269011-230p8rsf	469	26	the	the	DT
cord-269011-230p8rsf	469	27	particle	particle	NN
cord-269011-230p8rsf	469	28	volume	volume	NN
cord-269011-230p8rsf	469	29	.	.	.
cord-269011-230p8rsf	470	1	It	-PRON-	PRP
cord-269011-230p8rsf	470	2	is	be	VBZ
cord-269011-230p8rsf	470	3	presently	presently	RB
cord-269011-230p8rsf	470	4	unknown	unknown	JJ
cord-269011-230p8rsf	470	5	what	what	WP
cord-269011-230p8rsf	470	6	triggers	trigger	VBZ
cord-269011-230p8rsf	470	7	the	the	DT
cord-269011-230p8rsf	470	8	morphological	morphological	JJ
cord-269011-230p8rsf	470	9	reorganization	reorganization	NN
cord-269011-230p8rsf	470	10	in	in	IN
cord-269011-230p8rsf	470	11	the	the	DT
cord-269011-230p8rsf	470	12	Golgi	Golgi	NNP
cord-269011-230p8rsf	470	13	complex	complex	NN
cord-269011-230p8rsf	470	14	.	.	.
cord-269011-230p8rsf	471	1	Application	application	NN
cord-269011-230p8rsf	471	2	of	of	IN
cord-269011-230p8rsf	471	3	drugs	drug	NNS
cord-269011-230p8rsf	471	4	affecting	affect	VBG
cord-269011-230p8rsf	471	5	the	the	DT
cord-269011-230p8rsf	471	6	state	state	NN
cord-269011-230p8rsf	471	7	of	of	IN
cord-269011-230p8rsf	471	8	the	the	DT
cord-269011-230p8rsf	471	9	organelle	organelle	NN
cord-269011-230p8rsf	471	10	did	do	VBD
cord-269011-230p8rsf	471	11	not	not	RB
cord-269011-230p8rsf	471	12	give	give	VB
cord-269011-230p8rsf	471	13	clues	clue	NNS
cord-269011-230p8rsf	471	14	.	.	.
cord-269011-230p8rsf	472	1	As	as	IN
cord-269011-230p8rsf	472	2	virions	virion	NNS
cord-269011-230p8rsf	472	3	encounter	encounter	VBP
cord-269011-230p8rsf	472	4	an	an	DT
cord-269011-230p8rsf	472	5	increasingly	increasingly	RB
cord-269011-230p8rsf	472	6	acidic	acidic	JJ
cord-269011-230p8rsf	472	7	pH	ph	NN
cord-269011-230p8rsf	472	8	on	on	IN
cord-269011-230p8rsf	472	9	passage	passage	NN
cord-269011-230p8rsf	472	10	through	through	IN
cord-269011-230p8rsf	472	11	the	the	DT
cord-269011-230p8rsf	472	12	Golgi	Golgi	NNP
cord-269011-230p8rsf	472	13	stack	stack	NN
cord-269011-230p8rsf	472	14	,	,	,
cord-269011-230p8rsf	472	15	studies	study	NNS
cord-269011-230p8rsf	472	16	addressing	address	VBG
cord-269011-230p8rsf	472	17	this	this	DT
cord-269011-230p8rsf	472	18	parameter	parameter	NN
cord-269011-230p8rsf	472	19	were	be	VBD
cord-269011-230p8rsf	472	20	done	do	VBN
cord-269011-230p8rsf	472	21	with	with	IN
cord-269011-230p8rsf	472	22	lysosomotropic	lysosomotropic	JJ
cord-269011-230p8rsf	472	23	agents	agent	NNS
cord-269011-230p8rsf	472	24	.	.	.
cord-269011-230p8rsf	473	1	Thus	thus	RB
cord-269011-230p8rsf	473	2	,	,	,
cord-269011-230p8rsf	473	3	chloroquine	chloroquine	NN
cord-269011-230p8rsf	473	4	and	and	CC
cord-269011-230p8rsf	473	5	NH	NH	NNP
cord-269011-230p8rsf	473	6	4	4	CD
cord-269011-230p8rsf	473	7	Cl	Cl	NNP
cord-269011-230p8rsf	473	8	were	be	VBD
cord-269011-230p8rsf	473	9	applied	apply	VBN
cord-269011-230p8rsf	473	10	to	to	IN
cord-269011-230p8rsf	473	11	MHV	MHV	NNP
cord-269011-230p8rsf	473	12	-	-	HYPH
cord-269011-230p8rsf	473	13	infected	infect	VBN
cord-269011-230p8rsf	473	14	cells	cell	NNS
cord-269011-230p8rsf	473	15	to	to	TO
cord-269011-230p8rsf	473	16	elevate	elevate	VB
cord-269011-230p8rsf	473	17	the	the	DT
cord-269011-230p8rsf	473	18	pH	ph	NN
cord-269011-230p8rsf	473	19	at	at	IN
cord-269011-230p8rsf	473	20	the	the	DT
cord-269011-230p8rsf	473	21	trans	trans	NNP
cord-269011-230p8rsf	473	22	side	side	NN
cord-269011-230p8rsf	473	23	of	of	IN
cord-269011-230p8rsf	473	24	the	the	DT
cord-269011-230p8rsf	473	25	Golgi	Golgi	NNP
cord-269011-230p8rsf	473	26	complex	complex	NN
cord-269011-230p8rsf	473	27	,	,	,
cord-269011-230p8rsf	473	28	but	but	CC
cord-269011-230p8rsf	473	29	no	no	DT
cord-269011-230p8rsf	473	30	effect	effect	NN
cord-269011-230p8rsf	473	31	on	on	IN
cord-269011-230p8rsf	473	32	the	the	DT
cord-269011-230p8rsf	473	33	maturation	maturation	NN
cord-269011-230p8rsf	473	34	of	of	IN
cord-269011-230p8rsf	473	35	MHV	MHV	NNP
cord-269011-230p8rsf	473	36	was	be	VBD
cord-269011-230p8rsf	473	37	observed	observe	VBN
cord-269011-230p8rsf	473	38	(	(	-LRB-
cord-269011-230p8rsf	474	1	Tooze	Tooze	NNP
cord-269011-230p8rsf	474	2	et	et	NNP
cord-269011-230p8rsf	474	3	al	al	NNP
cord-269011-230p8rsf	474	4	.	.	NNP
cord-269011-230p8rsf	474	5	,	,	,
cord-269011-230p8rsf	474	6	1987	1987	CD
cord-269011-230p8rsf	474	7	)	)	-RRB-
cord-269011-230p8rsf	474	8	.	.	.
cord-269011-230p8rsf	475	1	Monensin	Monensin	NNP
cord-269011-230p8rsf	475	2	,	,	,
cord-269011-230p8rsf	475	3	a	a	DT
cord-269011-230p8rsf	475	4	drug	drug	NN
cord-269011-230p8rsf	475	5	that	that	WDT
cord-269011-230p8rsf	475	6	reversibly	reversibly	RB
cord-269011-230p8rsf	475	7	disorganizes	disorganize	VBZ
cord-269011-230p8rsf	475	8	the	the	DT
cord-269011-230p8rsf	475	9	Golgi	Golgi	NNP
cord-269011-230p8rsf	475	10	complex	complex	NN
cord-269011-230p8rsf	475	11	and	and	CC
cord-269011-230p8rsf	475	12	blocks	block	VBZ
cord-269011-230p8rsf	475	13	transport	transport	NN
cord-269011-230p8rsf	475	14	along	along	IN
cord-269011-230p8rsf	475	15	the	the	DT
cord-269011-230p8rsf	475	16	exocytic	exocytic	JJ
cord-269011-230p8rsf	475	17	pathway	pathway	NN
cord-269011-230p8rsf	475	18	,	,	,
cord-269011-230p8rsf	475	19	led	lead	VBD
cord-269011-230p8rsf	475	20	to	to	IN
cord-269011-230p8rsf	475	21	the	the	DT
cord-269011-230p8rsf	475	22	accumulation	accumulation	NN
cord-269011-230p8rsf	475	23	of	of	IN
cord-269011-230p8rsf	475	24	the	the	DT
cord-269011-230p8rsf	475	25	large	large	JJ
cord-269011-230p8rsf	475	26	,	,	,
cord-269011-230p8rsf	475	27	annular	annular	JJ
cord-269011-230p8rsf	475	28	TGEV	TGEV	NNP
cord-269011-230p8rsf	475	29	virions	virion	NNS
cord-269011-230p8rsf	475	30	;	;	:
cord-269011-230p8rsf	475	31	after	after	IN
cord-269011-230p8rsf	475	32	reversal	reversal	NN
cord-269011-230p8rsf	475	33	of	of	IN
cord-269011-230p8rsf	475	34	the	the	DT
cord-269011-230p8rsf	475	35	blockade	blockade	NN
cord-269011-230p8rsf	475	36	formation	formation	NN
cord-269011-230p8rsf	475	37	of	of	IN
cord-269011-230p8rsf	475	38	the	the	DT
cord-269011-230p8rsf	475	39	small	small	JJ
cord-269011-230p8rsf	475	40	,	,	,
cord-269011-230p8rsf	475	41	compact	compact	JJ
cord-269011-230p8rsf	475	42	particles	particle	NNS
cord-269011-230p8rsf	475	43	was	be	VBD
cord-269011-230p8rsf	475	44	again	again	RB
cord-269011-230p8rsf	475	45	restored	restore	VBN
cord-269011-230p8rsf	475	46	(	(	-LRB-
cord-269011-230p8rsf	476	1	Salanueva	Salanueva	NNP
cord-269011-230p8rsf	476	2	et	et	NNP
cord-269011-230p8rsf	476	3	al	al	NNP
cord-269011-230p8rsf	476	4	.	.	NNP
cord-269011-230p8rsf	476	5	,	,	,
cord-269011-230p8rsf	476	6	1999	1999	CD
cord-269011-230p8rsf	476	7	)	)	-RRB-
cord-269011-230p8rsf	476	8	.	.	.
cord-269011-230p8rsf	477	1	These	these	DT
cord-269011-230p8rsf	477	2	observations	observation	NNS
cord-269011-230p8rsf	477	3	confirm	confirm	VBP
cord-269011-230p8rsf	477	4	that	that	IN
cord-269011-230p8rsf	477	5	the	the	DT
cord-269011-230p8rsf	477	6	Golgi	Golgi	NNP
cord-269011-230p8rsf	477	7	complex	complex	NN
cord-269011-230p8rsf	477	8	is	be	VBZ
cord-269011-230p8rsf	477	9	necessary	necessary	JJ
cord-269011-230p8rsf	477	10	for	for	IN
cord-269011-230p8rsf	477	11	TGEV	TGEV	NNP
cord-269011-230p8rsf	477	12	structural	structural	JJ
cord-269011-230p8rsf	477	13	transformation	transformation	NN
cord-269011-230p8rsf	477	14	.	.	.
cord-269011-230p8rsf	478	1	Nocodazole	Nocodazole	NNP
cord-269011-230p8rsf	478	2	treatment	treatment	NN
cord-269011-230p8rsf	478	3	of	of	IN
cord-269011-230p8rsf	478	4	cells	cell	NNS
cord-269011-230p8rsf	478	5	causes	cause	VBZ
cord-269011-230p8rsf	478	6	a	a	DT
cord-269011-230p8rsf	478	7	reversible	reversible	JJ
cord-269011-230p8rsf	478	8	fragmentation	fragmentation	NN
cord-269011-230p8rsf	478	9	of	of	IN
cord-269011-230p8rsf	478	10	the	the	DT
cord-269011-230p8rsf	478	11	Golgi	Golgi	NNP
cord-269011-230p8rsf	478	12	complex	complex	NN
cord-269011-230p8rsf	478	13	.	.	.
cord-269011-230p8rsf	479	1	Under	under	IN
cord-269011-230p8rsf	479	2	these	these	DT
cord-269011-230p8rsf	479	3	conditions	condition	NNS
cord-269011-230p8rsf	479	4	TGEV	TGEV	NNP
cord-269011-230p8rsf	479	5	virions	virion	NNS
cord-269011-230p8rsf	479	6	were	be	VBD
cord-269011-230p8rsf	479	7	still	still	RB
cord-269011-230p8rsf	479	8	able	able	JJ
cord-269011-230p8rsf	479	9	to	to	TO
cord-269011-230p8rsf	479	10	undergo	undergo	VB
cord-269011-230p8rsf	479	11	normal	normal	JJ
cord-269011-230p8rsf	479	12	structural	structural	JJ
cord-269011-230p8rsf	479	13	maturation	maturation	NN
cord-269011-230p8rsf	479	14	.	.	.
cord-269011-230p8rsf	480	1	In	in	IN
cord-269011-230p8rsf	480	2	contrast	contrast	NN
cord-269011-230p8rsf	480	3	,	,	,
cord-269011-230p8rsf	480	4	still	still	RB
cord-269011-230p8rsf	480	5	another	another	DT
cord-269011-230p8rsf	480	6	Golgi	Golgi	NNP
cord-269011-230p8rsf	480	7	-	-	HYPH
cord-269011-230p8rsf	480	8	disrupting	disrupt	VBG
cord-269011-230p8rsf	480	9	compound	compound	NN
cord-269011-230p8rsf	480	10	,	,	,
cord-269011-230p8rsf	480	11	brefeldin	brefeldin	NNP
cord-269011-230p8rsf	480	12	A	A	NNP
cord-269011-230p8rsf	480	13	,	,	,
cord-269011-230p8rsf	480	14	prevented	prevent	VBD
cord-269011-230p8rsf	480	15	their	-PRON-	PRP$
cord-269011-230p8rsf	480	16	maturation	maturation	NN
cord-269011-230p8rsf	480	17	(	(	-LRB-
cord-269011-230p8rsf	480	18	Risco	Risco	NNP
cord-269011-230p8rsf	480	19	et	et	NNP
cord-269011-230p8rsf	480	20	al	al	NNP
cord-269011-230p8rsf	480	21	.	.	NNP
cord-269011-230p8rsf	480	22	,	,	,
cord-269011-230p8rsf	480	23	1998	1998	CD
cord-269011-230p8rsf	480	24	)	)	-RRB-
cord-269011-230p8rsf	480	25	.	.	.
cord-269011-230p8rsf	481	1	This	this	DT
cord-269011-230p8rsf	481	2	compound	compound	NN
cord-269011-230p8rsf	481	3	leads	lead	VBZ
cord-269011-230p8rsf	481	4	(	(	-LRB-
cord-269011-230p8rsf	482	1	Risco	Risco	NNP
cord-269011-230p8rsf	482	2	et	et	NNP
cord-269011-230p8rsf	482	3	al	al	NNP
cord-269011-230p8rsf	482	4	.	.	NNP
cord-269011-230p8rsf	482	5	,	,	,
cord-269011-230p8rsf	482	6	1998	1998	CD
cord-269011-230p8rsf	482	7	)	)	-RRB-
cord-269011-230p8rsf	482	8	.	.	.
cord-269011-230p8rsf	483	1	(	(	-LRB-
cord-269011-230p8rsf	483	2	B	b	NN
cord-269011-230p8rsf	483	3	)	)	-RRB-
cord-269011-230p8rsf	484	1	For	for	IN
cord-269011-230p8rsf	484	2	a	a	DT
cord-269011-230p8rsf	484	3	direct	direct	JJ
cord-269011-230p8rsf	484	4	comparison	comparison	NN
cord-269011-230p8rsf	484	5	of	of	IN
cord-269011-230p8rsf	484	6	size	size	NN
cord-269011-230p8rsf	484	7	and	and	CC
cord-269011-230p8rsf	484	8	morphology	morphology	NN
cord-269011-230p8rsf	484	9	a	a	DT
cord-269011-230p8rsf	484	10	small	small	JJ
cord-269011-230p8rsf	484	11	,	,	,
cord-269011-230p8rsf	484	12	dense	dense	JJ
cord-269011-230p8rsf	484	13	particle	particle	NN
cord-269011-230p8rsf	484	14	and	and	CC
cord-269011-230p8rsf	484	15	a	a	DT
cord-269011-230p8rsf	484	16	large	large	JJ
cord-269011-230p8rsf	484	17	particle	particle	NN
cord-269011-230p8rsf	484	18	are	be	VBP
cord-269011-230p8rsf	484	19	shown	show	VBN
cord-269011-230p8rsf	484	20	(	(	-LRB-
cord-269011-230p8rsf	484	21	Salanueva	Salanueva	NNP
cord-269011-230p8rsf	484	22	et	et	NNP
cord-269011-230p8rsf	484	23	al	al	NNP
cord-269011-230p8rsf	484	24	.	.	NNP
cord-269011-230p8rsf	484	25	,	,	,
cord-269011-230p8rsf	484	26	1999	1999	CD
cord-269011-230p8rsf	484	27	)	)	-RRB-
cord-269011-230p8rsf	484	28	.	.	.
cord-269011-230p8rsf	485	1	Pictures	picture	NNS
cord-269011-230p8rsf	485	2	were	be	VBD
cord-269011-230p8rsf	485	3	kindly	kindly	RB
cord-269011-230p8rsf	485	4	provided	provide	VBN
cord-269011-230p8rsf	485	5	by	by	IN
cord-269011-230p8rsf	485	6	C.	C.	NNP
cord-269011-230p8rsf	485	7	Risco	Risco	NNP
cord-269011-230p8rsf	485	8	.	.	.
cord-269011-230p8rsf	486	1	to	to	IN
cord-269011-230p8rsf	486	2	a	a	DT
cord-269011-230p8rsf	486	3	redistribution	redistribution	NN
cord-269011-230p8rsf	486	4	of	of	IN
cord-269011-230p8rsf	486	5	Golgi	Golgi	NNP
cord-269011-230p8rsf	486	6	membranes	membrane	NNS
cord-269011-230p8rsf	486	7	to	to	IN
cord-269011-230p8rsf	486	8	the	the	DT
cord-269011-230p8rsf	486	9	ER	ER	NNP
cord-269011-230p8rsf	486	10	,	,	,
cord-269011-230p8rsf	486	11	leaving	leave	VBG
cord-269011-230p8rsf	486	12	no	no	DT
cord-269011-230p8rsf	486	13	definable	definable	JJ
cord-269011-230p8rsf	486	14	Golgi	Golgi	NNP
cord-269011-230p8rsf	486	15	system	system	NN
cord-269011-230p8rsf	486	16	.	.	.
cord-269011-230p8rsf	487	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	487	2	,	,	,
cord-269011-230p8rsf	487	3	MHV	MHV	NNP
cord-269011-230p8rsf	487	4	particles	particle	NNS
cord-269011-230p8rsf	487	5	accumulated	accumulate	VBN
cord-269011-230p8rsf	487	6	in	in	IN
cord-269011-230p8rsf	487	7	infected	infected	JJ
cord-269011-230p8rsf	487	8	cells	cell	NNS
cord-269011-230p8rsf	487	9	under	under	IN
cord-269011-230p8rsf	487	10	these	these	DT
cord-269011-230p8rsf	487	11	conditions	condition	NNS
cord-269011-230p8rsf	487	12	appeared	appear	VBD
cord-269011-230p8rsf	487	13	to	to	TO
cord-269011-230p8rsf	487	14	be	be	VB
cord-269011-230p8rsf	487	15	infectious	infectious	JJ
cord-269011-230p8rsf	487	16	when	when	WRB
cord-269011-230p8rsf	487	17	liberated	liberate	VBN
cord-269011-230p8rsf	487	18	by	by	IN
cord-269011-230p8rsf	487	19	sonication	sonication	NN
cord-269011-230p8rsf	487	20	(	(	-LRB-
cord-269011-230p8rsf	487	21	J.	J.	NNP
cord-269011-230p8rsf	487	22	Meertens	Meertens	NNP
cord-269011-230p8rsf	487	23	and	and	CC
cord-269011-230p8rsf	487	24	P.	P.	NNP
cord-269011-230p8rsf	487	25	J.	J.	NNP
cord-269011-230p8rsf	487	26	M.	M.	NNP
cord-269011-230p8rsf	487	27	Rottier	Rottier	NNP
cord-269011-230p8rsf	487	28	,	,	,
cord-269011-230p8rsf	487	29	unpublished	unpublished	JJ
cord-269011-230p8rsf	487	30	results	result	NNS
cord-269011-230p8rsf	487	31	)	)	-RRB-
cord-269011-230p8rsf	487	32	,	,	,
cord-269011-230p8rsf	487	33	leaving	leave	VBG
cord-269011-230p8rsf	487	34	us	-PRON-	PRP
cord-269011-230p8rsf	487	35	with	with	IN
cord-269011-230p8rsf	487	36	an	an	DT
cord-269011-230p8rsf	487	37	intriguing	intriguing	JJ
cord-269011-230p8rsf	487	38	question	question	NN
cord-269011-230p8rsf	487	39	about	about	IN
cord-269011-230p8rsf	487	40	the	the	DT
cord-269011-230p8rsf	487	41	function	function	NN
cord-269011-230p8rsf	487	42	of	of	IN
cord-269011-230p8rsf	487	43	the	the	DT
cord-269011-230p8rsf	487	44	maturation	maturation	NN
cord-269011-230p8rsf	487	45	process	process	NN
cord-269011-230p8rsf	487	46	.	.	.
cord-269011-230p8rsf	488	1	A.	A.	NNP
cord-269011-230p8rsf	488	2	Nucleocapsid	Nucleocapsid	NNP
cord-269011-230p8rsf	488	3	Assembly	Assembly	NNP
cord-269011-230p8rsf	488	4	Helical	Helical	NNP
cord-269011-230p8rsf	488	5	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	488	6	are	be	VBP
cord-269011-230p8rsf	488	7	assembled	assemble	VBN
cord-269011-230p8rsf	488	8	in	in	IN
cord-269011-230p8rsf	488	9	the	the	DT
cord-269011-230p8rsf	488	10	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	488	11	of	of	IN
cord-269011-230p8rsf	488	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	488	13	-	-	HYPH
cord-269011-230p8rsf	488	14	infected	infect	VBN
cord-269011-230p8rsf	488	15	cells	cell	NNS
cord-269011-230p8rsf	488	16	.	.	.
cord-269011-230p8rsf	489	1	They	-PRON-	PRP
cord-269011-230p8rsf	489	2	have	have	VBP
cord-269011-230p8rsf	489	3	been	be	VBN
cord-269011-230p8rsf	489	4	recognized	recognize	VBN
cord-269011-230p8rsf	489	5	by	by	IN
cord-269011-230p8rsf	489	6	their	-PRON-	PRP$
cord-269011-230p8rsf	489	7	tubular	tubular	JJ
cord-269011-230p8rsf	489	8	appearance	appearance	NN
cord-269011-230p8rsf	489	9	in	in	IN
cord-269011-230p8rsf	489	10	electron	electron	NN
cord-269011-230p8rsf	489	11	microscopy	microscopy	NN
cord-269011-230p8rsf	489	12	studies	study	NNS
cord-269011-230p8rsf	489	13	with	with	IN
cord-269011-230p8rsf	489	14	several	several	JJ
cord-269011-230p8rsf	489	15	viruses	virus	NNS
cord-269011-230p8rsf	489	16	including	include	VBG
cord-269011-230p8rsf	489	17	IBV	IBV	NNP
cord-269011-230p8rsf	489	18	,	,	,
cord-269011-230p8rsf	489	19	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	489	20	,	,	,
cord-269011-230p8rsf	489	21	TGEV	TGEV	NNP
cord-269011-230p8rsf	489	22	,	,	,
cord-269011-230p8rsf	489	23	and	and	CC
cord-269011-230p8rsf	489	24	MHV	MHV	NNP
cord-269011-230p8rsf	489	25	(	(	-LRB-
cord-269011-230p8rsf	489	26	Becker	Becker	NNP
cord-269011-230p8rsf	489	27	et	et	NNP
cord-269011-230p8rsf	489	28	al	al	NNP
cord-269011-230p8rsf	489	29	.	.	NNP
cord-269011-230p8rsf	489	30	,	,	,
cord-269011-230p8rsf	489	31	1967	1967	CD
cord-269011-230p8rsf	489	32	;	;	:
cord-269011-230p8rsf	489	33	Chasey	Chasey	NNP
cord-269011-230p8rsf	489	34	and	and	CC
cord-269011-230p8rsf	489	35	Alexander	Alexander	NNP
cord-269011-230p8rsf	489	36	,	,	,
cord-269011-230p8rsf	489	37	1976	1976	CD
cord-269011-230p8rsf	489	38	;	;	:
cord-269011-230p8rsf	489	39	David	David	NNP
cord-269011-230p8rsf	489	40	-	-	HYPH
cord-269011-230p8rsf	489	41	Ferreira	Ferreira	NNP
cord-269011-230p8rsf	489	42	and	and	CC
cord-269011-230p8rsf	489	43	Manaker	Manaker	NNP
cord-269011-230p8rsf	489	44	,	,	,
cord-269011-230p8rsf	489	45	1965	1965	CD
cord-269011-230p8rsf	489	46	;	;	:
cord-269011-230p8rsf	489	47	Dubois	Dubois	NNP
cord-269011-230p8rsf	489	48	-	-	HYPH
cord-269011-230p8rsf	489	49	Dalcq	Dalcq	NNP
cord-269011-230p8rsf	489	50	et	et	NNP
cord-269011-230p8rsf	489	51	al	al	NNP
cord-269011-230p8rsf	489	52	.	.	NNP
cord-269011-230p8rsf	489	53	,	,	,
cord-269011-230p8rsf	489	54	1982	1982	CD
cord-269011-230p8rsf	489	55	;	;	:
cord-269011-230p8rsf	489	56	Hamre	Hamre	NNP
cord-269011-230p8rsf	489	57	et	et	NNP
cord-269011-230p8rsf	489	58	al	al	NNP
cord-269011-230p8rsf	489	59	.	.	NNP
cord-269011-230p8rsf	489	60	,	,	,
cord-269011-230p8rsf	489	61	1967	1967	CD
cord-269011-230p8rsf	489	62	;	;	:
cord-269011-230p8rsf	489	63	Massalski	Massalski	NNP
cord-269011-230p8rsf	489	64	et	et	NNP
cord-269011-230p8rsf	489	65	al	al	NNP
cord-269011-230p8rsf	489	66	.	.	NNP
cord-269011-230p8rsf	489	67	,	,	,
cord-269011-230p8rsf	489	68	1982	1982	CD
cord-269011-230p8rsf	489	69	;	;	:
cord-269011-230p8rsf	489	70	Oshiro	Oshiro	NNP
cord-269011-230p8rsf	489	71	et	et	NNP
cord-269011-230p8rsf	489	72	al	al	NNP
cord-269011-230p8rsf	489	73	.	.	NNP
cord-269011-230p8rsf	489	74	,	,	,
cord-269011-230p8rsf	489	75	1971	1971	CD
cord-269011-230p8rsf	489	76	;	;	:
cord-269011-230p8rsf	489	77	Risco	Risco	NNP
cord-269011-230p8rsf	489	78	et	et	NNP
cord-269011-230p8rsf	489	79	al	al	NNP
cord-269011-230p8rsf	489	80	.	.	NNP
cord-269011-230p8rsf	489	81	,	,	,
cord-269011-230p8rsf	489	82	1998	1998	CD
cord-269011-230p8rsf	489	83	)	)	-RRB-
cord-269011-230p8rsf	489	84	.	.	.
cord-269011-230p8rsf	490	1	Large	large	JJ
cord-269011-230p8rsf	490	2	inclusions	inclusion	NNS
cord-269011-230p8rsf	490	3	of	of	IN
cord-269011-230p8rsf	490	4	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	490	5	were	be	VBD
cord-269011-230p8rsf	490	6	seen	see	VBN
cord-269011-230p8rsf	490	7	to	to	TO
cord-269011-230p8rsf	490	8	accumulate	accumulate	VB
cord-269011-230p8rsf	490	9	late	late	RB
cord-269011-230p8rsf	490	10	in	in	IN
cord-269011-230p8rsf	490	11	the	the	DT
cord-269011-230p8rsf	490	12	infection	infection	NN
cord-269011-230p8rsf	490	13	of	of	IN
cord-269011-230p8rsf	490	14	cells	cell	NNS
cord-269011-230p8rsf	490	15	with	with	IN
cord-269011-230p8rsf	490	16	HCoV	HCoV	NNP
cord-269011-230p8rsf	490	17	(	(	-LRB-
cord-269011-230p8rsf	490	18	Caul	Caul	NNP
cord-269011-230p8rsf	490	19	and	and	CC
cord-269011-230p8rsf	490	20	Egglestone	Egglestone	NNP
cord-269011-230p8rsf	490	21	,	,	,
cord-269011-230p8rsf	490	22	1977	1977	CD
cord-269011-230p8rsf	490	23	)	)	-RRB-
cord-269011-230p8rsf	490	24	and	and	CC
cord-269011-230p8rsf	490	25	MHV	MHV	NNP
cord-269011-230p8rsf	490	26	-	-	HYPH
cord-269011-230p8rsf	490	27	JHM	JHM	NNP
cord-269011-230p8rsf	491	1	(	(	-LRB-
cord-269011-230p8rsf	491	2	Dubois-	Dubois-	NNP
cord-269011-230p8rsf	491	3	Dalcq	Dalcq	NNP
cord-269011-230p8rsf	491	4	et	et	NNP
cord-269011-230p8rsf	491	5	al	al	NNP
cord-269011-230p8rsf	491	6	.	.	NNP
cord-269011-230p8rsf	491	7	,	,	,
cord-269011-230p8rsf	491	8	1982	1982	CD
cord-269011-230p8rsf	491	9	)	)	-RRB-
cord-269011-230p8rsf	491	10	.	.	.
cord-269011-230p8rsf	492	1	The	the	DT
cord-269011-230p8rsf	492	2	structure	structure	NN
cord-269011-230p8rsf	492	3	of	of	IN
cord-269011-230p8rsf	492	4	the	the	DT
cord-269011-230p8rsf	492	5	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	492	6	as	as	IN
cord-269011-230p8rsf	492	7	it	-PRON-	PRP
cord-269011-230p8rsf	492	8	occurs	occur	VBZ
cord-269011-230p8rsf	492	9	in	in	IN
cord-269011-230p8rsf	492	10	infected	infected	JJ
cord-269011-230p8rsf	492	11	cells	cell	NNS
cord-269011-230p8rsf	492	12	has	have	VBZ
cord-269011-230p8rsf	492	13	not	not	RB
cord-269011-230p8rsf	492	14	been	be	VBN
cord-269011-230p8rsf	492	15	studied	study	VBN
cord-269011-230p8rsf	492	16	in	in	IN
cord-269011-230p8rsf	492	17	any	any	DT
cord-269011-230p8rsf	492	18	detail	detail	NN
cord-269011-230p8rsf	492	19	.	.	.
cord-269011-230p8rsf	493	1	Ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	493	2	particles	particle	NNS
cord-269011-230p8rsf	493	3	supposed	suppose	VBN
cord-269011-230p8rsf	493	4	to	to	TO
cord-269011-230p8rsf	493	5	represent	represent	VB
cord-269011-230p8rsf	493	6	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	493	7	have	have	VBP
cord-269011-230p8rsf	493	8	been	be	VBN
cord-269011-230p8rsf	493	9	isolated	isolate	VBN
cord-269011-230p8rsf	493	10	from	from	IN
cord-269011-230p8rsf	493	11	MHV	mhv	NN
cord-269011-230p8rsf	493	12	-	-	HYPH
cord-269011-230p8rsf	493	13	infected	infect	VBN
cord-269011-230p8rsf	493	14	cells	cell	NNS
cord-269011-230p8rsf	493	15	and	and	CC
cord-269011-230p8rsf	493	16	were	be	VBD
cord-269011-230p8rsf	493	17	shown	show	VBN
cord-269011-230p8rsf	493	18	to	to	TO
cord-269011-230p8rsf	493	19	consist	consist	VB
cord-269011-230p8rsf	493	20	of	of	IN
cord-269011-230p8rsf	493	21	genomic	genomic	JJ
cord-269011-230p8rsf	493	22	RNA	RNA	NNP
cord-269011-230p8rsf	493	23	and	and	CC
cord-269011-230p8rsf	493	24	N	N	NNP
cord-269011-230p8rsf	493	25	protein	protein	NN
cord-269011-230p8rsf	494	1	(	(	-LRB-
cord-269011-230p8rsf	494	2	Perlman	Perlman	NNP
cord-269011-230p8rsf	494	3	et	et	NNP
cord-269011-230p8rsf	494	4	al	al	NNP
cord-269011-230p8rsf	494	5	.	.	.
cord-269011-230p8rsf	495	1	,	,	,
cord-269011-230p8rsf	495	2	1986	1986	CD
cord-269011-230p8rsf	495	3	;	;	:
cord-269011-230p8rsf	495	4	Robb	Robb	NNP
cord-269011-230p8rsf	495	5	and	and	CC
cord-269011-230p8rsf	495	6	Bond	Bond	NNP
cord-269011-230p8rsf	495	7	,	,	,
cord-269011-230p8rsf	495	8	1979	1979	CD
cord-269011-230p8rsf	495	9	;	;	:
cord-269011-230p8rsf	495	10	Spaan	Spaan	NNP
cord-269011-230p8rsf	495	11	et	et	FW
cord-269011-230p8rsf	495	12	al	al	NNP
cord-269011-230p8rsf	495	13	.	.	NNP
cord-269011-230p8rsf	495	14	,	,	,
cord-269011-230p8rsf	495	15	1981	1981	CD
cord-269011-230p8rsf	495	16	)	)	-RRB-
cord-269011-230p8rsf	495	17	.	.	.
cord-269011-230p8rsf	496	1	The	the	DT
cord-269011-230p8rsf	496	2	particles	particle	NNS
cord-269011-230p8rsf	496	3	sedimented	sediment	VBN
cord-269011-230p8rsf	496	4	as	as	IN
cord-269011-230p8rsf	496	5	EDTA	edta	NN
cord-269011-230p8rsf	496	6	-	-	HYPH
cord-269011-230p8rsf	496	7	resistant	resistant	JJ
cord-269011-230p8rsf	496	8	structures	structure	NNS
cord-269011-230p8rsf	496	9	of	of	IN
cord-269011-230p8rsf	496	10	200	200	CD
cord-269011-230p8rsf	496	11	-	-	HYPH
cord-269011-230p8rsf	496	12	230S	230s	CD
cord-269011-230p8rsf	496	13	in	in	IN
cord-269011-230p8rsf	496	14	sucrose	sucrose	NN
cord-269011-230p8rsf	496	15	gradients	gradient	NNS
cord-269011-230p8rsf	496	16	.	.	.
cord-269011-230p8rsf	497	1	During	during	IN
cord-269011-230p8rsf	497	2	the	the	DT
cord-269011-230p8rsf	497	3	active	active	JJ
cord-269011-230p8rsf	497	4	phase	phase	NN
cord-269011-230p8rsf	497	5	of	of	IN
cord-269011-230p8rsf	497	6	viral	viral	JJ
cord-269011-230p8rsf	497	7	replication	replication	NN
cord-269011-230p8rsf	497	8	the	the	DT
cord-269011-230p8rsf	497	9	majority	majority	NN
cord-269011-230p8rsf	497	10	(	(	-LRB-
cord-269011-230p8rsf	497	11	90	90	CD
cord-269011-230p8rsf	497	12	%	%	NN
cord-269011-230p8rsf	497	13	)	)	-RRB-
cord-269011-230p8rsf	497	14	of	of	IN
cord-269011-230p8rsf	497	15	the	the	DT
cord-269011-230p8rsf	497	16	intracellular	intracellular	JJ
cord-269011-230p8rsf	497	17	genome	genome	NN
cord-269011-230p8rsf	497	18	-	-	HYPH
cord-269011-230p8rsf	497	19	size	size	NN
cord-269011-230p8rsf	497	20	RNA	RNA	NNP
cord-269011-230p8rsf	497	21	was	be	VBD
cord-269011-230p8rsf	497	22	found	find	VBN
cord-269011-230p8rsf	497	23	in	in	IN
cord-269011-230p8rsf	497	24	these	these	DT
cord-269011-230p8rsf	497	25	structures	structure	NNS
cord-269011-230p8rsf	497	26	(	(	-LRB-
cord-269011-230p8rsf	497	27	Spaan	Spaan	NNP
cord-269011-230p8rsf	497	28	et	et	FW
cord-269011-230p8rsf	497	29	al	al	NNP
cord-269011-230p8rsf	497	30	.	.	NNP
cord-269011-230p8rsf	497	31	,	,	,
cord-269011-230p8rsf	497	32	1981	1981	CD
cord-269011-230p8rsf	497	33	)	)	-RRB-
cord-269011-230p8rsf	497	34	.	.	.
cord-269011-230p8rsf	498	1	Ultrastructural	Ultrastructural	NNP
cord-269011-230p8rsf	498	2	studies	study	NNS
cord-269011-230p8rsf	498	3	of	of	IN
cord-269011-230p8rsf	498	4	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	498	5	derived	derive	VBN
cord-269011-230p8rsf	498	6	from	from	IN
cord-269011-230p8rsf	498	7	purified	purify	VBN
cord-269011-230p8rsf	498	8	virion	virion	NN
cord-269011-230p8rsf	498	9	preparations	preparation	NNS
cord-269011-230p8rsf	498	10	have	have	VBP
cord-269011-230p8rsf	498	11	shown	show	VBN
cord-269011-230p8rsf	498	12	quite	quite	PDT
cord-269011-230p8rsf	498	13	a	a	DT
cord-269011-230p8rsf	498	14	variety	variety	NN
cord-269011-230p8rsf	498	15	of	of	IN
cord-269011-230p8rsf	498	16	helical	helical	JJ
cord-269011-230p8rsf	498	17	structures	structure	NNS
cord-269011-230p8rsf	498	18	,	,	,
cord-269011-230p8rsf	498	19	depending	depend	VBG
cord-269011-230p8rsf	498	20	on	on	IN
cord-269011-230p8rsf	498	21	the	the	DT
cord-269011-230p8rsf	498	22	virus	virus	NN
cord-269011-230p8rsf	498	23	and	and	CC
cord-269011-230p8rsf	498	24	the	the	DT
cord-269011-230p8rsf	498	25	experimental	experimental	JJ
cord-269011-230p8rsf	498	26	conditions	condition	NNS
cord-269011-230p8rsf	498	27	used	use	VBN
cord-269011-230p8rsf	498	28	.	.	.
cord-269011-230p8rsf	499	1	The	the	DT
cord-269011-230p8rsf	499	2	overall	overall	JJ
cord-269011-230p8rsf	499	3	feature	feature	NN
cord-269011-230p8rsf	499	4	,	,	,
cord-269011-230p8rsf	499	5	however	however	RB
cord-269011-230p8rsf	499	6	,	,	,
cord-269011-230p8rsf	499	7	was	be	VBD
cord-269011-230p8rsf	499	8	that	that	DT
cord-269011-230p8rsf	499	9	of	of	IN
cord-269011-230p8rsf	499	10	a	a	DT
cord-269011-230p8rsf	499	11	thread	thread	NN
cord-269011-230p8rsf	499	12	-	-	HYPH
cord-269011-230p8rsf	499	13	like	like	JJ
cord-269011-230p8rsf	499	14	coil	coil	NN
cord-269011-230p8rsf	499	15	,	,	,
cord-269011-230p8rsf	499	16	sometimes	sometimes	RB
cord-269011-230p8rsf	499	17	appearing	appear	VBG
cord-269011-230p8rsf	499	18	to	to	TO
cord-269011-230p8rsf	499	19	be	be	VB
cord-269011-230p8rsf	499	20	hollow	hollow	JJ
cord-269011-230p8rsf	499	21	,	,	,
cord-269011-230p8rsf	499	22	with	with	IN
cord-269011-230p8rsf	499	23	a	a	DT
cord-269011-230p8rsf	499	24	diameter	diameter	NN
cord-269011-230p8rsf	499	25	varying	vary	VBG
cord-269011-230p8rsf	499	26	between	between	IN
cord-269011-230p8rsf	499	27	9	9	CD
cord-269011-230p8rsf	499	28	and	and	CC
cord-269011-230p8rsf	499	29	16	16	CD
cord-269011-230p8rsf	499	30	nm	nm	NN
cord-269011-230p8rsf	499	31	and	and	CC
cord-269011-230p8rsf	499	32	a	a	DT
cord-269011-230p8rsf	499	33	length	length	NN
cord-269011-230p8rsf	499	34	ranging	range	VBG
cord-269011-230p8rsf	499	35	from	from	IN
cord-269011-230p8rsf	499	36	0.32	0.32	CD
cord-269011-230p8rsf	499	37	mm	mm	NNS
cord-269011-230p8rsf	499	38	up	up	IN
cord-269011-230p8rsf	499	39	to	to	TO
cord-269011-230p8rsf	499	40	6	6	CD
cord-269011-230p8rsf	499	41	mm	mm	NN
cord-269011-230p8rsf	500	1	(	(	-LRB-
cord-269011-230p8rsf	500	2	Caul	Caul	NNP
cord-269011-230p8rsf	500	3	et	et	NNP
cord-269011-230p8rsf	500	4	al	al	NNP
cord-269011-230p8rsf	500	5	.	.	.
cord-269011-230p8rsf	501	1	,	,	,
cord-269011-230p8rsf	501	2	1979	1979	CD
cord-269011-230p8rsf	501	3	;	;	:
cord-269011-230p8rsf	501	4	Davies	Davies	NNP
cord-269011-230p8rsf	501	5	et	et	NNP
cord-269011-230p8rsf	501	6	al	al	NNP
cord-269011-230p8rsf	501	7	.	.	NNP
cord-269011-230p8rsf	501	8	,	,	,
cord-269011-230p8rsf	501	9	1981	1981	CD
cord-269011-230p8rsf	501	10	;	;	:
cord-269011-230p8rsf	501	11	Kennedy	Kennedy	NNP
cord-269011-230p8rsf	501	12	and	and	CC
cord-269011-230p8rsf	501	13	Johnson	Johnson	NNP
cord-269011-230p8rsf	501	14	-	-	HYPH
cord-269011-230p8rsf	501	15	Lussenburg	Lussenburg	NNP
cord-269011-230p8rsf	501	16	,	,	,
cord-269011-230p8rsf	501	17	1975	1975	CD
cord-269011-230p8rsf	501	18	;	;	:
cord-269011-230p8rsf	501	19	Macnaughton	Macnaughton	NNP
cord-269011-230p8rsf	501	20	and	and	CC
cord-269011-230p8rsf	501	21	Davies	Davies	NNP
cord-269011-230p8rsf	501	22	,	,	,
cord-269011-230p8rsf	501	23	1978	1978	CD
cord-269011-230p8rsf	501	24	)	)	-RRB-
cord-269011-230p8rsf	502	1	Biochemical	biochemical	JJ
cord-269011-230p8rsf	502	2	analysis	analysis	NN
cord-269011-230p8rsf	502	3	of	of	IN
cord-269011-230p8rsf	502	4	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	502	5	prepared	prepare	VBN
cord-269011-230p8rsf	502	6	by	by	IN
cord-269011-230p8rsf	502	7	detergent	detergent	NN
cord-269011-230p8rsf	502	8	disruption	disruption	NN
cord-269011-230p8rsf	502	9	of	of	IN
cord-269011-230p8rsf	502	10	purified	purify	VBN
cord-269011-230p8rsf	502	11	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	502	12	revealed	reveal	VBD
cord-269011-230p8rsf	502	13	the	the	DT
cord-269011-230p8rsf	502	14	presence	presence	NN
cord-269011-230p8rsf	502	15	of	of	IN
cord-269011-230p8rsf	502	16	genomic	genomic	JJ
cord-269011-230p8rsf	502	17	RNA	RNA	NNP
cord-269011-230p8rsf	502	18	and	and	CC
cord-269011-230p8rsf	502	19	N	N	NNP
cord-269011-230p8rsf	502	20	protein	protein	NN
cord-269011-230p8rsf	502	21	.	.	.
cord-269011-230p8rsf	503	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	503	2	,	,	,
cord-269011-230p8rsf	503	3	however	however	RB
cord-269011-230p8rsf	503	4	,	,	,
cord-269011-230p8rsf	503	5	particles	particle	NNS
cord-269011-230p8rsf	503	6	obtained	obtain	VBN
cord-269011-230p8rsf	503	7	by	by	IN
cord-269011-230p8rsf	503	8	treatment	treatment	NN
cord-269011-230p8rsf	503	9	of	of	IN
cord-269011-230p8rsf	503	10	virions	virion	NNS
cord-269011-230p8rsf	503	11	with	with	IN
cord-269011-230p8rsf	503	12	Nonidet	Nonidet	NNP
cord-269011-230p8rsf	503	13	P-40	P-40	NNP
cord-269011-230p8rsf	503	14	appeared	appear	VBD
cord-269011-230p8rsf	503	15	to	to	TO
cord-269011-230p8rsf	503	16	be	be	VB
cord-269011-230p8rsf	503	17	spherical	spherical	JJ
cord-269011-230p8rsf	503	18	when	when	WRB
cord-269011-230p8rsf	503	19	viewed	view	VBN
cord-269011-230p8rsf	503	20	under	under	IN
cord-269011-230p8rsf	503	21	the	the	DT
cord-269011-230p8rsf	503	22	electron	electron	NN
cord-269011-230p8rsf	503	23	microscope	microscope	NN
cord-269011-230p8rsf	503	24	and	and	CC
cord-269011-230p8rsf	503	25	,	,	,
cord-269011-230p8rsf	503	26	in	in	IN
cord-269011-230p8rsf	503	27	addition	addition	NN
cord-269011-230p8rsf	503	28	,	,	,
cord-269011-230p8rsf	503	29	to	to	TO
cord-269011-230p8rsf	503	30	contain	contain	VB
cord-269011-230p8rsf	503	31	M	M	NNP
cord-269011-230p8rsf	503	32	protein	protein	NN
cord-269011-230p8rsf	503	33	,	,	,
cord-269011-230p8rsf	503	34	as	as	IN
cord-269011-230p8rsf	503	35	was	be	VBD
cord-269011-230p8rsf	503	36	observed	observe	VBN
cord-269011-230p8rsf	503	37	with	with	IN
cord-269011-230p8rsf	503	38	TGEV	TGEV	NNP
cord-269011-230p8rsf	503	39	(	(	-LRB-
cord-269011-230p8rsf	503	40	Garwes	Garwes	NNP
cord-269011-230p8rsf	503	41	et	et	FW
cord-269011-230p8rsf	503	42	al	al	NNP
cord-269011-230p8rsf	503	43	.	.	NNP
cord-269011-230p8rsf	503	44	,	,	,
cord-269011-230p8rsf	503	45	1976	1976	CD
cord-269011-230p8rsf	503	46	)	)	-RRB-
cord-269011-230p8rsf	503	47	,	,	,
cord-269011-230p8rsf	503	48	HEV	HEV	NNP
cord-269011-230p8rsf	503	49	(	(	-LRB-
cord-269011-230p8rsf	503	50	Pocock	Pocock	NNP
cord-269011-230p8rsf	503	51	and	and	CC
cord-269011-230p8rsf	503	52	Garwes	Garwes	NNP
cord-269011-230p8rsf	503	53	,	,	,
cord-269011-230p8rsf	503	54	1977	1977	CD
cord-269011-230p8rsf	503	55	)	)	-RRB-
cord-269011-230p8rsf	503	56	,	,	,
cord-269011-230p8rsf	503	57	and	and	CC
cord-269011-230p8rsf	503	58	MHV	MHV	NNP
cord-269011-230p8rsf	503	59	-	-	HYPH
cord-269011-230p8rsf	503	60	JHM	JHM	NNP
cord-269011-230p8rsf	503	61	(	(	-LRB-
cord-269011-230p8rsf	503	62	Wege	Wege	NNP
cord-269011-230p8rsf	503	63	et	et	NNP
cord-269011-230p8rsf	503	64	al	al	NNP
cord-269011-230p8rsf	503	65	.	.	NNP
cord-269011-230p8rsf	503	66	,	,	,
cord-269011-230p8rsf	503	67	1979	1979	CD
cord-269011-230p8rsf	503	68	)	)	-RRB-
cord-269011-230p8rsf	503	69	.	.	.
cord-269011-230p8rsf	504	1	The	the	DT
cord-269011-230p8rsf	504	2	presence	presence	NN
cord-269011-230p8rsf	504	3	of	of	IN
cord-269011-230p8rsf	504	4	the	the	DT
cord-269011-230p8rsf	504	5	M	M	NNP
cord-269011-230p8rsf	504	6	protein	protein	NN
cord-269011-230p8rsf	504	7	was	be	VBD
cord-269011-230p8rsf	504	8	found	find	VBN
cord-269011-230p8rsf	504	9	for	for	IN
cord-269011-230p8rsf	504	10	MHV	MHV	NNP
cord-269011-230p8rsf	504	11	-	-	HYPH
cord-269011-230p8rsf	504	12	A59	A59	NNP
cord-269011-230p8rsf	504	13	to	to	TO
cord-269011-230p8rsf	504	14	depend	depend	VB
cord-269011-230p8rsf	504	15	on	on	IN
cord-269011-230p8rsf	504	16	the	the	DT
cord-269011-230p8rsf	504	17	preparation	preparation	NN
cord-269011-230p8rsf	504	18	conditions	condition	NNS
cord-269011-230p8rsf	504	19	.	.	.
cord-269011-230p8rsf	505	1	Whereas	whereas	IN
cord-269011-230p8rsf	505	2	the	the	DT
cord-269011-230p8rsf	505	3	protein	protein	NN
cord-269011-230p8rsf	505	4	was	be	VBD
cord-269011-230p8rsf	505	5	absent	absent	JJ
cord-269011-230p8rsf	505	6	when	when	WRB
cord-269011-230p8rsf	505	7	the	the	DT
cord-269011-230p8rsf	505	8	virions	virion	NNS
cord-269011-230p8rsf	505	9	had	have	VBD
cord-269011-230p8rsf	505	10	been	be	VBN
cord-269011-230p8rsf	505	11	disrupted	disrupt	VBN
cord-269011-230p8rsf	505	12	with	with	IN
cord-269011-230p8rsf	505	13	Nonidet	Nonidet	NNP
cord-269011-230p8rsf	505	14	P-40	P-40	NNP
cord-269011-230p8rsf	505	15	at	at	IN
cord-269011-230p8rsf	505	16	4	4	CD
cord-269011-230p8rsf	505	17	C	c	NN
cord-269011-230p8rsf	505	18	,	,	,
cord-269011-230p8rsf	505	19	solubilization	solubilization	NN
cord-269011-230p8rsf	505	20	at	at	IN
cord-269011-230p8rsf	505	21	37	37	CD
cord-269011-230p8rsf	505	22	C	C	NNP
cord-269011-230p8rsf	505	23	resulted	result	VBD
cord-269011-230p8rsf	505	24	in	in	IN
cord-269011-230p8rsf	505	25	copurification	copurification	NN
cord-269011-230p8rsf	505	26	of	of	IN
cord-269011-230p8rsf	505	27	M	M	NNP
cord-269011-230p8rsf	505	28	protein	protein	NN
cord-269011-230p8rsf	505	29	with	with	IN
cord-269011-230p8rsf	505	30	the	the	DT
cord-269011-230p8rsf	505	31	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	505	32	(	(	-LRB-
cord-269011-230p8rsf	505	33	Sturman	Sturman	NNP
cord-269011-230p8rsf	505	34	et	et	NNP
cord-269011-230p8rsf	505	35	al	al	NNP
cord-269011-230p8rsf	505	36	.	.	NNP
cord-269011-230p8rsf	505	37	,	,	,
cord-269011-230p8rsf	505	38	1980	1980	CD
cord-269011-230p8rsf	505	39	)	)	-RRB-
cord-269011-230p8rsf	505	40	.	.	.
cord-269011-230p8rsf	506	1	The	the	DT
cord-269011-230p8rsf	506	2	higher	high	JJR
cord-269011-230p8rsf	506	3	temperature	temperature	NN
cord-269011-230p8rsf	506	4	was	be	VBD
cord-269011-230p8rsf	506	5	found	find	VBN
cord-269011-230p8rsf	506	6	to	to	TO
cord-269011-230p8rsf	506	7	cause	cause	VB
cord-269011-230p8rsf	506	8	a	a	DT
cord-269011-230p8rsf	506	9	conformational	conformational	JJ
cord-269011-230p8rsf	506	10	change	change	NN
cord-269011-230p8rsf	506	11	in	in	IN
cord-269011-230p8rsf	506	12	the	the	DT
cord-269011-230p8rsf	506	13	M	M	NNP
cord-269011-230p8rsf	506	14	protein	protein	NN
cord-269011-230p8rsf	506	15	,	,	,
cord-269011-230p8rsf	506	16	leading	lead	VBG
cord-269011-230p8rsf	506	17	to	to	IN
cord-269011-230p8rsf	506	18	its	-PRON-	PRP$
cord-269011-230p8rsf	506	19	aggregation	aggregation	NN
cord-269011-230p8rsf	506	20	and	and	CC
cord-269011-230p8rsf	506	21	association	association	NN
cord-269011-230p8rsf	506	22	with	with	IN
cord-269011-230p8rsf	506	23	the	the	DT
cord-269011-230p8rsf	506	24	viral	viral	JJ
cord-269011-230p8rsf	506	25	RNA	RNA	NNP
cord-269011-230p8rsf	506	26	in	in	IN
cord-269011-230p8rsf	506	27	the	the	DT
cord-269011-230p8rsf	506	28	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	506	29	.	.	.
cord-269011-230p8rsf	507	1	Similarly	similarly	RB
cord-269011-230p8rsf	507	2	,	,	,
cord-269011-230p8rsf	507	3	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	507	4	structures	structure	NNS
cord-269011-230p8rsf	507	5	essentially	essentially	RB
cord-269011-230p8rsf	507	6	lacking	lack	VBG
cord-269011-230p8rsf	507	7	the	the	DT
cord-269011-230p8rsf	507	8	M	M	NNP
cord-269011-230p8rsf	507	9	protein	protein	NN
cord-269011-230p8rsf	507	10	were	be	VBD
cord-269011-230p8rsf	507	11	also	also	RB
cord-269011-230p8rsf	507	12	reported	report	VBN
cord-269011-230p8rsf	507	13	for	for	IN
cord-269011-230p8rsf	507	14	IBV	IBV	NNP
cord-269011-230p8rsf	507	15	when	when	WRB
cord-269011-230p8rsf	507	16	virions	virion	NNS
cord-269011-230p8rsf	507	17	were	be	VBD
cord-269011-230p8rsf	507	18	treated	treat	VBN
cord-269011-230p8rsf	507	19	with	with	IN
cord-269011-230p8rsf	507	20	detergent	detergent	NN
cord-269011-230p8rsf	507	21	at	at	IN
cord-269011-230p8rsf	507	22	low	low	JJ
cord-269011-230p8rsf	507	23	temperature	temperature	NN
cord-269011-230p8rsf	508	1	(	(	-LRB-
cord-269011-230p8rsf	508	2	Davies	Davies	NNP
cord-269011-230p8rsf	508	3	et	et	NNP
cord-269011-230p8rsf	508	4	al	al	NNP
cord-269011-230p8rsf	508	5	.	.	NNP
cord-269011-230p8rsf	508	6	,	,	,
cord-269011-230p8rsf	508	7	1981	1981	CD
cord-269011-230p8rsf	508	8	)	)	-RRB-
cord-269011-230p8rsf	508	9	.	.	.
cord-269011-230p8rsf	509	1	Although	although	IN
cord-269011-230p8rsf	509	2	there	there	EX
cord-269011-230p8rsf	509	3	is	be	VBZ
cord-269011-230p8rsf	509	4	no	no	DT
cord-269011-230p8rsf	509	5	direct	direct	JJ
cord-269011-230p8rsf	509	6	evidence	evidence	NN
cord-269011-230p8rsf	509	7	yet	yet	RB
cord-269011-230p8rsf	509	8	,	,	,
cord-269011-230p8rsf	509	9	it	-PRON-	PRP
cord-269011-230p8rsf	509	10	seems	seem	VBZ
cord-269011-230p8rsf	509	11	reasonable	reasonable	JJ
cord-269011-230p8rsf	509	12	to	to	TO
cord-269011-230p8rsf	509	13	assume	assume	VB
cord-269011-230p8rsf	509	14	that	that	IN
cord-269011-230p8rsf	509	15	the	the	DT
cord-269011-230p8rsf	509	16	helical	helical	JJ
cord-269011-230p8rsf	509	17	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	509	18	seen	see	VBN
cord-269011-230p8rsf	509	19	accumulating	accumulate	VBG
cord-269011-230p8rsf	509	20	in	in	IN
cord-269011-230p8rsf	509	21	the	the	DT
cord-269011-230p8rsf	509	22	cytosol	cytosol	NN
cord-269011-230p8rsf	509	23	of	of	IN
cord-269011-230p8rsf	509	24	infected	infected	JJ
cord-269011-230p8rsf	509	25	cells	cell	NNS
cord-269011-230p8rsf	509	26	constitute	constitute	VBP
cord-269011-230p8rsf	509	27	the	the	DT
cord-269011-230p8rsf	509	28	reservoir	reservoir	NN
cord-269011-230p8rsf	509	29	that	that	WDT
cord-269011-230p8rsf	509	30	feeds	feed	VBZ
cord-269011-230p8rsf	509	31	into	into	IN
cord-269011-230p8rsf	509	32	the	the	DT
cord-269011-230p8rsf	509	33	viral	viral	JJ
cord-269011-230p8rsf	509	34	budding	bud	VBG
cord-269011-230p8rsf	509	35	system	system	NN
cord-269011-230p8rsf	509	36	.	.	.
cord-269011-230p8rsf	510	1	The	the	DT
cord-269011-230p8rsf	510	2	location	location	NN
cord-269011-230p8rsf	510	3	where	where	WRB
cord-269011-230p8rsf	510	4	these	these	DT
cord-269011-230p8rsf	510	5	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	510	6	are	be	VBP
cord-269011-230p8rsf	510	7	assembled	assemble	VBN
cord-269011-230p8rsf	510	8	has	have	VBZ
cord-269011-230p8rsf	510	9	not	not	RB
cord-269011-230p8rsf	510	10	been	be	VBN
cord-269011-230p8rsf	510	11	defined	define	VBN
cord-269011-230p8rsf	510	12	.	.	.
cord-269011-230p8rsf	511	1	Their	-PRON-	PRP$
cord-269011-230p8rsf	511	2	production	production	NN
cord-269011-230p8rsf	511	3	may	may	MD
cord-269011-230p8rsf	511	4	take	take	VB
cord-269011-230p8rsf	511	5	place	place	NN
cord-269011-230p8rsf	511	6	either	either	CC
cord-269011-230p8rsf	511	7	free	free	JJ
cord-269011-230p8rsf	511	8	in	in	IN
cord-269011-230p8rsf	511	9	the	the	DT
cord-269011-230p8rsf	511	10	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	511	11	,	,	,
cord-269011-230p8rsf	511	12	where	where	WRB
cord-269011-230p8rsf	511	13	the	the	DT
cord-269011-230p8rsf	511	14	N	N	NNP
cord-269011-230p8rsf	511	15	protein	protein	NN
cord-269011-230p8rsf	511	16	is	be	VBZ
cord-269011-230p8rsf	511	17	synthesized	synthesize	VBN
cord-269011-230p8rsf	511	18	,	,	,
cord-269011-230p8rsf	511	19	or	or	CC
cord-269011-230p8rsf	511	20	,	,	,
cord-269011-230p8rsf	511	21	alternatively	alternatively	RB
cord-269011-230p8rsf	511	22	,	,	,
cord-269011-230p8rsf	511	23	in	in	IN
cord-269011-230p8rsf	511	24	association	association	NN
cord-269011-230p8rsf	511	25	with	with	IN
cord-269011-230p8rsf	511	26	the	the	DT
cord-269011-230p8rsf	511	27	membrane	membrane	NN
cord-269011-230p8rsf	511	28	-	-	HYPH
cord-269011-230p8rsf	511	29	bound	bind	VBN
cord-269011-230p8rsf	511	30	structures	structure	NNS
cord-269011-230p8rsf	511	31	where	where	WRB
cord-269011-230p8rsf	511	32	genomic	genomic	JJ
cord-269011-230p8rsf	511	33	RNA	RNA	NNP
cord-269011-230p8rsf	511	34	is	be	VBZ
cord-269011-230p8rsf	511	35	produced	produce	VBN
cord-269011-230p8rsf	511	36	.	.	.
cord-269011-230p8rsf	512	1	The	the	DT
cord-269011-230p8rsf	512	2	observed	observed	JJ
cord-269011-230p8rsf	512	3	colocalization	colocalization	NN
cord-269011-230p8rsf	512	4	of	of	IN
cord-269011-230p8rsf	512	5	N	n	CD
cord-269011-230p8rsf	512	6	protein	protein	NN
cord-269011-230p8rsf	512	7	with	with	IN
cord-269011-230p8rsf	512	8	the	the	DT
cord-269011-230p8rsf	512	9	replication	replication	NN
cord-269011-230p8rsf	512	10	complexes	complex	NNS
cord-269011-230p8rsf	512	11	(	(	-LRB-
cord-269011-230p8rsf	512	12	Bost	Bost	NNP
cord-269011-230p8rsf	512	13	et	et	NNP
cord-269011-230p8rsf	512	14	al	al	NNP
cord-269011-230p8rsf	512	15	.	.	NNP
cord-269011-230p8rsf	512	16	,	,	,
cord-269011-230p8rsf	512	17	2000	2000	CD
cord-269011-230p8rsf	512	18	(	(	-LRB-
cord-269011-230p8rsf	512	19	Bost	Bost	NNP
cord-269011-230p8rsf	512	20	et	et	NNP
cord-269011-230p8rsf	512	21	al	al	NNP
cord-269011-230p8rsf	512	22	.	.	NNP
cord-269011-230p8rsf	512	23	,	,	,
cord-269011-230p8rsf	512	24	,	,	,
cord-269011-230p8rsf	512	25	2001	2001	CD
cord-269011-230p8rsf	512	26	Denison	Denison	NNP
cord-269011-230p8rsf	512	27	et	et	NNP
cord-269011-230p8rsf	512	28	al	al	NNP
cord-269011-230p8rsf	512	29	.	.	NNP
cord-269011-230p8rsf	512	30	,	,	,
cord-269011-230p8rsf	512	31	1999	1999	CD
cord-269011-230p8rsf	512	32	;	;	:
cord-269011-230p8rsf	512	33	van	van	NNP
cord-269011-230p8rsf	512	34	der	der	NNP
cord-269011-230p8rsf	512	35	Meer	Meer	NNP
cord-269011-230p8rsf	512	36	et	et	NNP
cord-269011-230p8rsf	512	37	al	al	NNP
cord-269011-230p8rsf	512	38	.	.	NNP
cord-269011-230p8rsf	512	39	,	,	,
cord-269011-230p8rsf	512	40	1999	1999	CD
cord-269011-230p8rsf	512	41	)	)	-RRB-
cord-269011-230p8rsf	512	42	is	be	VBZ
cord-269011-230p8rsf	512	43	consistent	consistent	JJ
cord-269011-230p8rsf	512	44	with	with	IN
cord-269011-230p8rsf	512	45	the	the	DT
cord-269011-230p8rsf	512	46	latter	latter	JJ
cord-269011-230p8rsf	512	47	possibility	possibility	NN
cord-269011-230p8rsf	512	48	.	.	.
cord-269011-230p8rsf	513	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	513	2	replication	replication	NN
cord-269011-230p8rsf	513	3	appears	appear	VBZ
cord-269011-230p8rsf	513	4	to	to	TO
cord-269011-230p8rsf	513	5	occur	occur	VB
cord-269011-230p8rsf	513	6	on	on	IN
cord-269011-230p8rsf	513	7	double	double	JJ
cord-269011-230p8rsf	513	8	-	-	HYPH
cord-269011-230p8rsf	513	9	membrane	membrane	NN
cord-269011-230p8rsf	513	10	vesicles	vesicle	NNS
cord-269011-230p8rsf	513	11	(	(	-LRB-
cord-269011-230p8rsf	513	12	Gosert	Gosert	NNP
cord-269011-230p8rsf	513	13	et	et	NNP
cord-269011-230p8rsf	513	14	al	al	NNP
cord-269011-230p8rsf	513	15	.	.	NNP
cord-269011-230p8rsf	513	16	,	,	,
cord-269011-230p8rsf	513	17	2002	2002	CD
cord-269011-230p8rsf	513	18	)	)	-RRB-
cord-269011-230p8rsf	513	19	,	,	,
cord-269011-230p8rsf	513	20	which	which	WDT
cord-269011-230p8rsf	513	21	utilize	utilize	VBP
cord-269011-230p8rsf	513	22	components	component	NNS
cord-269011-230p8rsf	513	23	of	of	IN
cord-269011-230p8rsf	513	24	the	the	DT
cord-269011-230p8rsf	513	25	cellular	cellular	JJ
cord-269011-230p8rsf	513	26	autophagy	autophagy	NN
cord-269011-230p8rsf	513	27	pathway	pathway	NN
cord-269011-230p8rsf	513	28	(	(	-LRB-
cord-269011-230p8rsf	513	29	Prentice	Prentice	NNP
cord-269011-230p8rsf	513	30	et	et	NNP
cord-269011-230p8rsf	513	31	al	al	NNP
cord-269011-230p8rsf	513	32	.	.	NNP
cord-269011-230p8rsf	513	33	,	,	,
cord-269011-230p8rsf	513	34	2004	2004	CD
cord-269011-230p8rsf	513	35	)	)	-RRB-
cord-269011-230p8rsf	513	36	.	.	.
cord-269011-230p8rsf	514	1	Whereas	whereas	IN
cord-269011-230p8rsf	514	2	early	early	RB
cord-269011-230p8rsf	514	3	in	in	IN
cord-269011-230p8rsf	514	4	infection	infection	NN
cord-269011-230p8rsf	514	5	the	the	DT
cord-269011-230p8rsf	514	6	replication	replication	NN
cord-269011-230p8rsf	514	7	complexes	complex	NNS
cord-269011-230p8rsf	514	8	were	be	VBD
cord-269011-230p8rsf	514	9	shown	show	VBN
cord-269011-230p8rsf	514	10	to	to	TO
cord-269011-230p8rsf	514	11	be	be	VB
cord-269011-230p8rsf	514	12	almost	almost	RB
cord-269011-230p8rsf	514	13	entirely	entirely	RB
cord-269011-230p8rsf	514	14	discrete	discrete	JJ
cord-269011-230p8rsf	514	15	from	from	IN
cord-269011-230p8rsf	514	16	sites	site	NNS
cord-269011-230p8rsf	514	17	of	of	IN
cord-269011-230p8rsf	514	18	M	M	NNP
cord-269011-230p8rsf	514	19	protein	protein	NN
cord-269011-230p8rsf	514	20	accumulation	accumulation	NN
cord-269011-230p8rsf	514	21	,	,	,
cord-269011-230p8rsf	514	22	at	at	IN
cord-269011-230p8rsf	514	23	later	later	JJ
cord-269011-230p8rsf	514	24	times	time	NNS
cord-269011-230p8rsf	514	25	of	of	IN
cord-269011-230p8rsf	514	26	infection	infection	NN
cord-269011-230p8rsf	514	27	helicase	helicase	NN
cord-269011-230p8rsf	514	28	and	and	CC
cord-269011-230p8rsf	514	29	N	n	CD
cord-269011-230p8rsf	514	30	proteins	protein	NNS
cord-269011-230p8rsf	514	31	appeared	appear	VBD
cord-269011-230p8rsf	514	32	to	to	IN
cord-269011-230p8rsf	514	33	colocalize	colocalize	NNP
cord-269011-230p8rsf	514	34	with	with	IN
cord-269011-230p8rsf	514	35	the	the	DT
cord-269011-230p8rsf	514	36	M	M	NNP
cord-269011-230p8rsf	514	37	protein	protein	NN
cord-269011-230p8rsf	514	38	(	(	-LRB-
cord-269011-230p8rsf	514	39	Bost	Bost	NNP
cord-269011-230p8rsf	514	40	et	et	NNP
cord-269011-230p8rsf	514	41	al	al	NNP
cord-269011-230p8rsf	514	42	.	.	NNP
cord-269011-230p8rsf	514	43	,	,	,
cord-269011-230p8rsf	514	44	2000	2000	CD
cord-269011-230p8rsf	514	45	(	(	-LRB-
cord-269011-230p8rsf	514	46	Bost	Bost	NNP
cord-269011-230p8rsf	514	47	et	et	NNP
cord-269011-230p8rsf	514	48	al	al	NNP
cord-269011-230p8rsf	514	49	.	.	NNP
cord-269011-230p8rsf	514	50	,	,	,
cord-269011-230p8rsf	514	51	,	,	,
cord-269011-230p8rsf	514	52	2001	2001	CD
cord-269011-230p8rsf	514	53	.	.	.
cord-269011-230p8rsf	515	1	It	-PRON-	PRP
cord-269011-230p8rsf	515	2	was	be	VBD
cord-269011-230p8rsf	515	3	proposed	propose	VBN
cord-269011-230p8rsf	515	4	that	that	IN
cord-269011-230p8rsf	515	5	the	the	DT
cord-269011-230p8rsf	515	6	translocation	translocation	NN
cord-269011-230p8rsf	515	7	of	of	IN
cord-269011-230p8rsf	515	8	helicase	helicase	NNP
cord-269011-230p8rsf	515	9	-	-	HYPH
cord-269011-230p8rsf	515	10	N	N	NNP
cord-269011-230p8rsf	515	11	protein	protein	NN
cord-269011-230p8rsf	515	12	complexes	complex	NNS
cord-269011-230p8rsf	515	13	to	to	IN
cord-269011-230p8rsf	515	14	sites	site	NNS
cord-269011-230p8rsf	515	15	of	of	IN
cord-269011-230p8rsf	515	16	virus	virus	NN
cord-269011-230p8rsf	515	17	assembly	assembly	NN
cord-269011-230p8rsf	515	18	may	may	MD
cord-269011-230p8rsf	515	19	serve	serve	VB
cord-269011-230p8rsf	515	20	as	as	IN
cord-269011-230p8rsf	515	21	a	a	DT
cord-269011-230p8rsf	515	22	mechanism	mechanism	NN
cord-269011-230p8rsf	515	23	to	to	TO
cord-269011-230p8rsf	515	24	deliver	deliver	VB
cord-269011-230p8rsf	515	25	the	the	DT
cord-269011-230p8rsf	515	26	newly	newly	RB
cord-269011-230p8rsf	515	27	synthesized	synthesize	VBN
cord-269011-230p8rsf	515	28	RNA	RNA	NNP
cord-269011-230p8rsf	515	29	and	and	CC
cord-269011-230p8rsf	515	30	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	515	31	and	and	CC
cord-269011-230p8rsf	515	32	to	to	TO
cord-269011-230p8rsf	515	33	facilitate	facilitate	VB
cord-269011-230p8rsf	515	34	the	the	DT
cord-269011-230p8rsf	515	35	retention	retention	NN
cord-269011-230p8rsf	515	36	of	of	IN
cord-269011-230p8rsf	515	37	the	the	DT
cord-269011-230p8rsf	515	38	M	M	NNP
cord-269011-230p8rsf	515	39	protein	protein	NN
cord-269011-230p8rsf	515	40	in	in	IN
cord-269011-230p8rsf	515	41	the	the	DT
cord-269011-230p8rsf	515	42	intermediate	intermediate	JJ
cord-269011-230p8rsf	515	43	compartment	compartment	NN
cord-269011-230p8rsf	515	44	.	.	.
cord-269011-230p8rsf	516	1	Encapsidation	encapsidation	NN
cord-269011-230p8rsf	516	2	of	of	IN
cord-269011-230p8rsf	516	3	genomic	genomic	JJ
cord-269011-230p8rsf	516	4	RNA	RNA	NNP
cord-269011-230p8rsf	516	5	into	into	IN
cord-269011-230p8rsf	516	6	a	a	DT
cord-269011-230p8rsf	516	7	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	516	8	is	be	VBZ
cord-269011-230p8rsf	516	9	presumably	presumably	RB
cord-269011-230p8rsf	516	10	initiated	initiate	VBN
cord-269011-230p8rsf	516	11	by	by	IN
cord-269011-230p8rsf	516	12	an	an	DT
cord-269011-230p8rsf	516	13	interaction	interaction	NN
cord-269011-230p8rsf	516	14	of	of	IN
cord-269011-230p8rsf	516	15	the	the	DT
cord-269011-230p8rsf	516	16	N	n	CD
cord-269011-230p8rsf	516	17	protein	protein	NN
cord-269011-230p8rsf	516	18	with	with	IN
cord-269011-230p8rsf	516	19	a	a	DT
cord-269011-230p8rsf	516	20	specific	specific	JJ
cord-269011-230p8rsf	516	21	nucleotide	nucleotide	JJ
cord-269011-230p8rsf	516	22	sequence	sequence	NN
cord-269011-230p8rsf	516	23	,	,	,
cord-269011-230p8rsf	516	24	the	the	DT
cord-269011-230p8rsf	516	25	packaging	packaging	NN
cord-269011-230p8rsf	516	26	signal	signal	NN
cord-269011-230p8rsf	516	27	,	,	,
cord-269011-230p8rsf	516	28	which	which	WDT
cord-269011-230p8rsf	516	29	is	be	VBZ
cord-269011-230p8rsf	516	30	subsequently	subsequently	RB
cord-269011-230p8rsf	516	31	followed	follow	VBN
cord-269011-230p8rsf	516	32	by	by	IN
cord-269011-230p8rsf	516	33	the	the	DT
cord-269011-230p8rsf	516	34	polymerization	polymerization	NN
cord-269011-230p8rsf	516	35	of	of	IN
cord-269011-230p8rsf	516	36	N	n	CD
cord-269011-230p8rsf	516	37	proteins	protein	NNS
cord-269011-230p8rsf	516	38	around	around	IN
cord-269011-230p8rsf	516	39	the	the	DT
cord-269011-230p8rsf	516	40	RNA	RNA	NNP
cord-269011-230p8rsf	516	41	molecule	molecule	NN
cord-269011-230p8rsf	516	42	in	in	IN
cord-269011-230p8rsf	516	43	a	a	DT
cord-269011-230p8rsf	516	44	nonsequence	nonsequence	NN
cord-269011-230p8rsf	516	45	-	-	HYPH
cord-269011-230p8rsf	516	46	specific	specific	JJ
cord-269011-230p8rsf	516	47	manner	manner	NN
cord-269011-230p8rsf	516	48	.	.	.
cord-269011-230p8rsf	517	1	The	the	DT
cord-269011-230p8rsf	517	2	selective	selective	JJ
cord-269011-230p8rsf	517	3	incorporation	incorporation	NN
cord-269011-230p8rsf	517	4	of	of	IN
cord-269011-230p8rsf	517	5	genomic	genomic	JJ
cord-269011-230p8rsf	517	6	RNA	RNA	NNP
cord-269011-230p8rsf	517	7	into	into	IN
cord-269011-230p8rsf	517	8	virions	virion	NNS
cord-269011-230p8rsf	517	9	would	would	MD
cord-269011-230p8rsf	517	10	predict	predict	VB
cord-269011-230p8rsf	517	11	the	the	DT
cord-269011-230p8rsf	517	12	packaging	packaging	NN
cord-269011-230p8rsf	517	13	signal	signal	NN
cord-269011-230p8rsf	517	14	to	to	TO
cord-269011-230p8rsf	517	15	be	be	VB
cord-269011-230p8rsf	517	16	located	locate	VBN
cord-269011-230p8rsf	517	17	in	in	IN
cord-269011-230p8rsf	517	18	sequences	sequence	NNS
cord-269011-230p8rsf	517	19	unique	unique	JJ
cord-269011-230p8rsf	517	20	to	to	IN
cord-269011-230p8rsf	517	21	this	this	DT
cord-269011-230p8rsf	517	22	RNA	RNA	NNP
cord-269011-230p8rsf	517	23	,	,	,
cord-269011-230p8rsf	517	24	that	that	RB
cord-269011-230p8rsf	517	25	is	is	RB
cord-269011-230p8rsf	517	26	,	,	,
cord-269011-230p8rsf	517	27	within	within	IN
cord-269011-230p8rsf	517	28	the	the	DT
cord-269011-230p8rsf	517	29	approximately	approximately	RB
cord-269011-230p8rsf	517	30	20-kb	20-kb	CD
cord-269011-230p8rsf	517	31	region	region	NN
cord-269011-230p8rsf	517	32	comprising	comprise	VBG
cord-269011-230p8rsf	517	33	the	the	DT
cord-269011-230p8rsf	517	34	5	5	CD
cord-269011-230p8rsf	517	35	0	0	CD
cord-269011-230p8rsf	517	36	UTR	UTR	NNP
cord-269011-230p8rsf	517	37	and	and	CC
cord-269011-230p8rsf	517	38	open	open	JJ
cord-269011-230p8rsf	517	39	reading	reading	NN
cord-269011-230p8rsf	517	40	frame	frame	NN
cord-269011-230p8rsf	517	41	1	1	CD
cord-269011-230p8rsf	517	42	(	(	-LRB-
cord-269011-230p8rsf	517	43	ORF1	ORF1	NNP
cord-269011-230p8rsf	517	44	)	)	-RRB-
cord-269011-230p8rsf	517	45	with	with	IN
cord-269011-230p8rsf	517	46	the	the	DT
cord-269011-230p8rsf	517	47	exception	exception	NN
cord-269011-230p8rsf	517	48	of	of	IN
cord-269011-230p8rsf	517	49	the	the	DT
cord-269011-230p8rsf	517	50	leader	leader	NN
cord-269011-230p8rsf	517	51	sequence	sequence	NN
cord-269011-230p8rsf	517	52	.	.	.
cord-269011-230p8rsf	518	1	Although	although	IN
cord-269011-230p8rsf	518	2	the	the	DT
cord-269011-230p8rsf	518	3	data	datum	NNS
cord-269011-230p8rsf	518	4	obtained	obtain	VBN
cord-269011-230p8rsf	518	5	so	so	RB
cord-269011-230p8rsf	518	6	far	far	RB
cord-269011-230p8rsf	518	7	support	support	VBP
cord-269011-230p8rsf	518	8	this	this	DT
cord-269011-230p8rsf	518	9	prediction	prediction	NN
cord-269011-230p8rsf	518	10	,	,	,
cord-269011-230p8rsf	518	11	no	no	DT
cord-269011-230p8rsf	518	12	consistent	consistent	JJ
cord-269011-230p8rsf	518	13	picture	picture	NN
cord-269011-230p8rsf	518	14	has	have	VBZ
cord-269011-230p8rsf	518	15	emerged	emerge	VBN
cord-269011-230p8rsf	518	16	yet	yet	RB
cord-269011-230p8rsf	518	17	.	.	.
cord-269011-230p8rsf	519	1	The	the	DT
cord-269011-230p8rsf	519	2	approach	approach	NN
cord-269011-230p8rsf	519	3	generally	generally	RB
cord-269011-230p8rsf	519	4	used	use	VBN
cord-269011-230p8rsf	519	5	to	to	TO
cord-269011-230p8rsf	519	6	map	map	VB
cord-269011-230p8rsf	519	7	the	the	DT
cord-269011-230p8rsf	519	8	packaging	packaging	NN
cord-269011-230p8rsf	519	9	signal	signal	NN
cord-269011-230p8rsf	519	10	involved	involve	VBD
cord-269011-230p8rsf	519	11	the	the	DT
cord-269011-230p8rsf	519	12	study	study	NN
cord-269011-230p8rsf	519	13	of	of	IN
cord-269011-230p8rsf	519	14	helper	helper	NN
cord-269011-230p8rsf	519	15	virus	virus	NN
cord-269011-230p8rsf	519	16	-	-	HYPH
cord-269011-230p8rsf	519	17	assisted	assist	VBN
cord-269011-230p8rsf	519	18	encapsidation	encapsidation	NN
cord-269011-230p8rsf	519	19	of	of	IN
cord-269011-230p8rsf	519	20	natural	natural	JJ
cord-269011-230p8rsf	519	21	and	and	CC
cord-269011-230p8rsf	519	22	artificially	artificially	RB
cord-269011-230p8rsf	519	23	obtained	obtain	VBN
cord-269011-230p8rsf	519	24	defective	defective	JJ
cord-269011-230p8rsf	519	25	RNA	RNA	NNP
cord-269011-230p8rsf	519	26	genomes	genome	NNS
cord-269011-230p8rsf	519	27	.	.	.
cord-269011-230p8rsf	520	1	Thus	thus	RB
cord-269011-230p8rsf	520	2	,	,	,
cord-269011-230p8rsf	520	3	a	a	DT
cord-269011-230p8rsf	520	4	650-nucleotide	650-nucleotide	CD
cord-269011-230p8rsf	520	5	region	region	NN
cord-269011-230p8rsf	520	6	located	locate	VBN
cord-269011-230p8rsf	520	7	at	at	IN
cord-269011-230p8rsf	520	8	the	the	DT
cord-269011-230p8rsf	520	9	3	3	CD
cord-269011-230p8rsf	520	10	0	0	CD
cord-269011-230p8rsf	520	11	end	end	NN
cord-269011-230p8rsf	520	12	of	of	IN
cord-269011-230p8rsf	520	13	the	the	DT
cord-269011-230p8rsf	520	14	pol1b	pol1b	NNP
cord-269011-230p8rsf	520	15	gene	gene	NN
cord-269011-230p8rsf	520	16	was	be	VBD
cord-269011-230p8rsf	520	17	initially	initially	RB
cord-269011-230p8rsf	520	18	identified	identify	VBN
cord-269011-230p8rsf	520	19	for	for	IN
cord-269011-230p8rsf	520	20	MHV	MHV	NNP
cord-269011-230p8rsf	520	21	(	(	-LRB-
cord-269011-230p8rsf	520	22	van	van	NNP
cord-269011-230p8rsf	520	23	der	der	NNP
cord-269011-230p8rsf	520	24	Most	Most	NNP
cord-269011-230p8rsf	520	25	et	et	NNP
cord-269011-230p8rsf	520	26	al	al	NNP
cord-269011-230p8rsf	520	27	.	.	NNP
cord-269011-230p8rsf	520	28	,	,	,
cord-269011-230p8rsf	520	29	1991	1991	CD
cord-269011-230p8rsf	520	30	)	)	-RRB-
cord-269011-230p8rsf	520	31	,	,	,
cord-269011-230p8rsf	520	32	which	which	WDT
cord-269011-230p8rsf	520	33	was	be	VBD
cord-269011-230p8rsf	520	34	subsequently	subsequently	RB
cord-269011-230p8rsf	520	35	narrowed	narrow	VBN
cord-269011-230p8rsf	520	36	to	to	IN
cord-269011-230p8rsf	520	37	an	an	DT
cord-269011-230p8rsf	520	38	area	area	NN
cord-269011-230p8rsf	520	39	of	of	IN
cord-269011-230p8rsf	520	40	190	190	CD
cord-269011-230p8rsf	520	41	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	520	42	(	(	-LRB-
cord-269011-230p8rsf	520	43	Fosmire	Fosmire	NNP
cord-269011-230p8rsf	520	44	et	et	NNP
cord-269011-230p8rsf	520	45	al	al	NNP
cord-269011-230p8rsf	520	46	.	.	NNP
cord-269011-230p8rsf	520	47	,	,	,
cord-269011-230p8rsf	520	48	1992	1992	CD
cord-269011-230p8rsf	520	49	)	)	-RRB-
cord-269011-230p8rsf	520	50	.	.	.
cord-269011-230p8rsf	521	1	Within	within	IN
cord-269011-230p8rsf	521	2	this	this	DT
cord-269011-230p8rsf	521	3	area	area	NN
cord-269011-230p8rsf	521	4	a	a	DT
cord-269011-230p8rsf	521	5	stable	stable	JJ
cord-269011-230p8rsf	521	6	stem	stem	NN
cord-269011-230p8rsf	521	7	-	-	HYPH
cord-269011-230p8rsf	521	8	loop	loop	NN
cord-269011-230p8rsf	521	9	of	of	IN
cord-269011-230p8rsf	521	10	69	69	CD
cord-269011-230p8rsf	521	11	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	521	12	was	be	VBD
cord-269011-230p8rsf	521	13	predicted	predict	VBN
cord-269011-230p8rsf	521	14	.	.	.
cord-269011-230p8rsf	522	1	Mutation	mutation	NN
cord-269011-230p8rsf	522	2	studies	study	NNS
cord-269011-230p8rsf	522	3	revealed	reveal	VBD
cord-269011-230p8rsf	522	4	that	that	IN
cord-269011-230p8rsf	522	5	the	the	DT
cord-269011-230p8rsf	522	6	integrity	integrity	NN
cord-269011-230p8rsf	522	7	of	of	IN
cord-269011-230p8rsf	522	8	this	this	DT
cord-269011-230p8rsf	522	9	secondary	secondary	JJ
cord-269011-230p8rsf	522	10	structure	structure	NN
cord-269011-230p8rsf	522	11	was	be	VBD
cord-269011-230p8rsf	522	12	important	important	JJ
cord-269011-230p8rsf	522	13	and	and	CC
cord-269011-230p8rsf	522	14	that	that	IN
cord-269011-230p8rsf	522	15	the	the	DT
cord-269011-230p8rsf	522	16	sequence	sequence	NN
cord-269011-230p8rsf	522	17	of	of	IN
cord-269011-230p8rsf	522	18	the	the	DT
cord-269011-230p8rsf	522	19	packaging	packaging	NN
cord-269011-230p8rsf	522	20	signal	signal	NN
cord-269011-230p8rsf	522	21	could	could	MD
cord-269011-230p8rsf	522	22	be	be	VB
cord-269011-230p8rsf	522	23	trimmed	trim	VBN
cord-269011-230p8rsf	522	24	further	further	RB
cord-269011-230p8rsf	522	25	to	to	IN
cord-269011-230p8rsf	522	26	a	a	DT
cord-269011-230p8rsf	522	27	minimum	minimum	JJ
cord-269011-230p8rsf	522	28	stretch	stretch	NN
cord-269011-230p8rsf	522	29	of	of	IN
cord-269011-230p8rsf	522	30	61	61	CD
cord-269011-230p8rsf	522	31	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	522	32	(	(	-LRB-
cord-269011-230p8rsf	522	33	Fosmire	Fosmire	NNP
cord-269011-230p8rsf	522	34	et	et	NNP
cord-269011-230p8rsf	522	35	al	al	NNP
cord-269011-230p8rsf	522	36	.	.	NNP
cord-269011-230p8rsf	522	37	,	,	,
cord-269011-230p8rsf	522	38	1992	1992	CD
cord-269011-230p8rsf	522	39	)	)	-RRB-
cord-269011-230p8rsf	522	40	.	.	.
cord-269011-230p8rsf	523	1	The	the	DT
cord-269011-230p8rsf	523	2	signal	signal	NN
cord-269011-230p8rsf	523	3	appeared	appear	VBD
cord-269011-230p8rsf	523	4	to	to	TO
cord-269011-230p8rsf	523	5	be	be	VB
cord-269011-230p8rsf	523	6	sufficient	sufficient	JJ
cord-269011-230p8rsf	523	7	for	for	IN
cord-269011-230p8rsf	523	8	RNA	RNA	NNP
cord-269011-230p8rsf	523	9	packaging	packaging	NN
cord-269011-230p8rsf	523	10	as	as	IN
cord-269011-230p8rsf	523	11	its	-PRON-	PRP$
cord-269011-230p8rsf	523	12	inclusion	inclusion	NN
cord-269011-230p8rsf	523	13	allowed	allow	VBD
cord-269011-230p8rsf	523	14	a	a	DT
cord-269011-230p8rsf	523	15	synthetic	synthetic	JJ
cord-269011-230p8rsf	523	16	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	523	17	mRNA	mrna	NN
cord-269011-230p8rsf	523	18	of	of	IN
cord-269011-230p8rsf	523	19	MHV	MHV	NNP
cord-269011-230p8rsf	523	20	-	-	HYPH
cord-269011-230p8rsf	523	21	A59	A59	NNP
cord-269011-230p8rsf	523	22	to	to	TO
cord-269011-230p8rsf	523	23	be	be	VB
cord-269011-230p8rsf	523	24	packaged	package	VBN
cord-269011-230p8rsf	523	25	specifically	specifically	RB
cord-269011-230p8rsf	523	26	;	;	:
cord-269011-230p8rsf	523	27	the	the	DT
cord-269011-230p8rsf	523	28	encapsidation	encapsidation	NN
cord-269011-230p8rsf	523	29	efficiency	efficiency	NN
cord-269011-230p8rsf	523	30	of	of	IN
cord-269011-230p8rsf	523	31	the	the	DT
cord-269011-230p8rsf	523	32	mRNA	mrna	NN
cord-269011-230p8rsf	523	33	was	be	VBD
cord-269011-230p8rsf	523	34	,	,	,
cord-269011-230p8rsf	523	35	however	however	RB
cord-269011-230p8rsf	523	36	,	,	,
cord-269011-230p8rsf	523	37	significantly	significantly	RB
cord-269011-230p8rsf	523	38	lower	low	JJR
cord-269011-230p8rsf	523	39	than	than	IN
cord-269011-230p8rsf	523	40	that	that	DT
cord-269011-230p8rsf	523	41	of	of	IN
cord-269011-230p8rsf	523	42	the	the	DT
cord-269011-230p8rsf	523	43	defective	defective	JJ
cord-269011-230p8rsf	523	44	genomic	genomic	JJ
cord-269011-230p8rsf	523	45	RNA	RNA	NNP
cord-269011-230p8rsf	523	46	from	from	IN
cord-269011-230p8rsf	523	47	which	which	WDT
cord-269011-230p8rsf	523	48	it	-PRON-	PRP
cord-269011-230p8rsf	523	49	was	be	VBD
cord-269011-230p8rsf	523	50	transcribed	transcribe	VBN
cord-269011-230p8rsf	523	51	.	.	.
cord-269011-230p8rsf	524	1	Even	even	RB
cord-269011-230p8rsf	524	2	a	a	DT
cord-269011-230p8rsf	524	3	nonviral	nonviral	JJ
cord-269011-230p8rsf	524	4	RNA	RNA	NNP
cord-269011-230p8rsf	524	5	was	be	VBD
cord-269011-230p8rsf	524	6	found	find	VBN
cord-269011-230p8rsf	524	7	to	to	TO
cord-269011-230p8rsf	524	8	be	be	VB
cord-269011-230p8rsf	524	9	packaged	package	VBN
cord-269011-230p8rsf	524	10	into	into	IN
cord-269011-230p8rsf	524	11	MHV	MHV	NNP
cord-269011-230p8rsf	524	12	particles	particle	NNS
cord-269011-230p8rsf	524	13	when	when	WRB
cord-269011-230p8rsf	524	14	provided	provide	VBN
cord-269011-230p8rsf	524	15	with	with	IN
cord-269011-230p8rsf	524	16	the	the	DT
cord-269011-230p8rsf	524	17	packaging	packaging	NN
cord-269011-230p8rsf	524	18	signal	signal	NN
cord-269011-230p8rsf	524	19	(	(	-LRB-
cord-269011-230p8rsf	524	20	Woo	woo	UH
cord-269011-230p8rsf	524	21	et	et	FW
cord-269011-230p8rsf	524	22	al	al	NNP
cord-269011-230p8rsf	524	23	.	.	NNP
cord-269011-230p8rsf	524	24	,	,	,
cord-269011-230p8rsf	524	25	1997	1997	CD
cord-269011-230p8rsf	524	26	)	)	-RRB-
cord-269011-230p8rsf	524	27	.	.	.
cord-269011-230p8rsf	525	1	Buoyant	buoyant	JJ
cord-269011-230p8rsf	525	2	density	density	NN
cord-269011-230p8rsf	525	3	analysis	analysis	NN
cord-269011-230p8rsf	525	4	of	of	IN
cord-269011-230p8rsf	525	5	the	the	DT
cord-269011-230p8rsf	525	6	particles	particle	NNS
cord-269011-230p8rsf	525	7	revealed	reveal	VBD
cord-269011-230p8rsf	525	8	that	that	IN
cord-269011-230p8rsf	525	9	the	the	DT
cord-269011-230p8rsf	525	10	RNA	RNA	NNP
cord-269011-230p8rsf	525	11	was	be	VBD
cord-269011-230p8rsf	525	12	not	not	RB
cord-269011-230p8rsf	525	13	assembled	assemble	VBN
cord-269011-230p8rsf	525	14	separately	separately	RB
cord-269011-230p8rsf	525	15	but	but	CC
cord-269011-230p8rsf	525	16	copackaged	copackage	VBN
cord-269011-230p8rsf	525	17	with	with	IN
cord-269011-230p8rsf	525	18	helper	helper	NN
cord-269011-230p8rsf	525	19	virus	virus	NN
cord-269011-230p8rsf	525	20	RNA	RNA	NNP
cord-269011-230p8rsf	525	21	.	.	.
cord-269011-230p8rsf	526	1	Studies	study	NNS
cord-269011-230p8rsf	526	2	of	of	IN
cord-269011-230p8rsf	526	3	the	the	DT
cord-269011-230p8rsf	526	4	corresponding	corresponding	JJ
cord-269011-230p8rsf	526	5	pol1b	pol1b	JJ
cord-269011-230p8rsf	526	6	region	region	NN
cord-269011-230p8rsf	526	7	of	of	IN
cord-269011-230p8rsf	526	8	another	another	DT
cord-269011-230p8rsf	526	9	group	group	NN
cord-269011-230p8rsf	526	10	2	2	CD
cord-269011-230p8rsf	526	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	526	12	,	,	,
cord-269011-230p8rsf	526	13	BCoV	BCoV	NNP
cord-269011-230p8rsf	526	14	,	,	,
cord-269011-230p8rsf	526	15	indicated	indicate	VBD
cord-269011-230p8rsf	526	16	that	that	IN
cord-269011-230p8rsf	526	17	within	within	IN
cord-269011-230p8rsf	526	18	this	this	DT
cord-269011-230p8rsf	526	19	group	group	NN
cord-269011-230p8rsf	526	20	the	the	DT
cord-269011-230p8rsf	526	21	packaging	packaging	NN
cord-269011-230p8rsf	526	22	signal	signal	NN
cord-269011-230p8rsf	526	23	is	be	VBZ
cord-269011-230p8rsf	526	24	structurally	structurally	RB
cord-269011-230p8rsf	526	25	and	and	CC
cord-269011-230p8rsf	526	26	functionally	functionally	RB
cord-269011-230p8rsf	526	27	conserved	conserved	JJ
cord-269011-230p8rsf	526	28	.	.	.
cord-269011-230p8rsf	527	1	A	a	DT
cord-269011-230p8rsf	527	2	69-nucleotide	69-nucleotide	CD
cord-269011-230p8rsf	527	3	sequence	sequence	NN
cord-269011-230p8rsf	527	4	with	with	IN
cord-269011-230p8rsf	527	5	significant	significant	JJ
cord-269011-230p8rsf	527	6	homology	homology	NN
cord-269011-230p8rsf	527	7	(	(	-LRB-
cord-269011-230p8rsf	527	8	74	74	CD
cord-269011-230p8rsf	527	9	%	%	NN
cord-269011-230p8rsf	527	10	)	)	-RRB-
cord-269011-230p8rsf	527	11	to	to	IN
cord-269011-230p8rsf	527	12	that	that	DT
cord-269011-230p8rsf	527	13	of	of	IN
cord-269011-230p8rsf	527	14	MHV	MHV	NNP
cord-269011-230p8rsf	527	15	was	be	VBD
cord-269011-230p8rsf	527	16	identified	identify	VBN
cord-269011-230p8rsf	527	17	within	within	IN
cord-269011-230p8rsf	527	18	a	a	DT
cord-269011-230p8rsf	527	19	cloned	clone	VBN
cord-269011-230p8rsf	527	20	291-nucleotide	291-nucleotide	CD
cord-269011-230p8rsf	527	21	segment	segment	NN
cord-269011-230p8rsf	527	22	sharing	share	VBG
cord-269011-230p8rsf	527	23	72	72	CD
cord-269011-230p8rsf	527	24	%	%	NN
cord-269011-230p8rsf	527	25	homology	homology	NN
cord-269011-230p8rsf	527	26	overall	overall	RB
cord-269011-230p8rsf	527	27	.	.	.
cord-269011-230p8rsf	528	1	When	when	WRB
cord-269011-230p8rsf	528	2	this	this	DT
cord-269011-230p8rsf	528	3	segment	segment	NN
cord-269011-230p8rsf	528	4	was	be	VBD
cord-269011-230p8rsf	528	5	fused	fuse	VBN
cord-269011-230p8rsf	528	6	to	to	IN
cord-269011-230p8rsf	528	7	a	a	DT
cord-269011-230p8rsf	528	8	noncoronavirus	noncoronavirus	JJ
cord-269011-230p8rsf	528	9	reporter	reporter	NN
cord-269011-230p8rsf	528	10	gene	gene	NN
cord-269011-230p8rsf	528	11	sequence	sequence	NN
cord-269011-230p8rsf	528	12	,	,	,
cord-269011-230p8rsf	528	13	the	the	DT
cord-269011-230p8rsf	528	14	resulting	result	VBG
cord-269011-230p8rsf	528	15	RNA	RNA	NNP
cord-269011-230p8rsf	528	16	appeared	appear	VBD
cord-269011-230p8rsf	528	17	to	to	TO
cord-269011-230p8rsf	528	18	be	be	VB
cord-269011-230p8rsf	528	19	packaged	package	VBN
cord-269011-230p8rsf	528	20	not	not	RB
cord-269011-230p8rsf	528	21	only	only	RB
cord-269011-230p8rsf	528	22	by	by	IN
cord-269011-230p8rsf	528	23	the	the	DT
cord-269011-230p8rsf	528	24	homologous	homologous	JJ
cord-269011-230p8rsf	528	25	helper	helper	NN
cord-269011-230p8rsf	528	26	virus	virus	NN
cord-269011-230p8rsf	528	27	BCoV	BCoV	NNP
cord-269011-230p8rsf	528	28	but	but	CC
cord-269011-230p8rsf	528	29	also	also	RB
cord-269011-230p8rsf	528	30	by	by	IN
cord-269011-230p8rsf	528	31	MHV	MHV	NNP
cord-269011-230p8rsf	528	32	.	.	.
cord-269011-230p8rsf	529	1	Conversely	conversely	RB
cord-269011-230p8rsf	529	2	,	,	,
cord-269011-230p8rsf	529	3	when	when	WRB
cord-269011-230p8rsf	529	4	the	the	DT
cord-269011-230p8rsf	529	5	MHV	MHV	NNP
cord-269011-230p8rsf	529	6	packaging	packaging	NN
cord-269011-230p8rsf	529	7	signal	signal	NN
cord-269011-230p8rsf	529	8	was	be	VBD
cord-269011-230p8rsf	529	9	fused	fuse	VBN
cord-269011-230p8rsf	529	10	to	to	IN
cord-269011-230p8rsf	529	11	the	the	DT
cord-269011-230p8rsf	529	12	reporter	reporter	NN
cord-269011-230p8rsf	529	13	gene	gene	NN
cord-269011-230p8rsf	529	14	sequence	sequence	NN
cord-269011-230p8rsf	529	15	,	,	,
cord-269011-230p8rsf	529	16	the	the	DT
cord-269011-230p8rsf	529	17	RNA	RNA	NNP
cord-269011-230p8rsf	529	18	was	be	VBD
cord-269011-230p8rsf	529	19	found	find	VBN
cord-269011-230p8rsf	529	20	to	to	TO
cord-269011-230p8rsf	529	21	be	be	VB
cord-269011-230p8rsf	529	22	encapsidated	encapsidate	VBN
cord-269011-230p8rsf	529	23	also	also	RB
cord-269011-230p8rsf	529	24	in	in	IN
cord-269011-230p8rsf	529	25	the	the	DT
cord-269011-230p8rsf	529	26	context	context	NN
cord-269011-230p8rsf	529	27	of	of	IN
cord-269011-230p8rsf	529	28	a	a	DT
cord-269011-230p8rsf	529	29	BCoV	BCoV	NNP
cord-269011-230p8rsf	529	30	-	-	HYPH
cord-269011-230p8rsf	529	31	infected	infect	VBN
cord-269011-230p8rsf	529	32	cell	cell	NN
cord-269011-230p8rsf	529	33	.	.	.
cord-269011-230p8rsf	530	1	Mapping	mapping	NN
cord-269011-230p8rsf	530	2	studies	study	NNS
cord-269011-230p8rsf	530	3	of	of	IN
cord-269011-230p8rsf	530	4	packaging	packaging	NN
cord-269011-230p8rsf	530	5	signals	signal	NNS
cord-269011-230p8rsf	530	6	in	in	IN
cord-269011-230p8rsf	530	7	the	the	DT
cord-269011-230p8rsf	530	8	genomes	genome	NNS
cord-269011-230p8rsf	530	9	of	of	IN
cord-269011-230p8rsf	530	10	group	group	NN
cord-269011-230p8rsf	530	11	1	1	CD
cord-269011-230p8rsf	530	12	and	and	CC
cord-269011-230p8rsf	530	13	group	group	NN
cord-269011-230p8rsf	530	14	3	3	CD
cord-269011-230p8rsf	530	15	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	530	16	have	have	VBP
cord-269011-230p8rsf	530	17	yielded	yield	VBN
cord-269011-230p8rsf	530	18	quite	quite	RB
cord-269011-230p8rsf	530	19	different	different	JJ
cord-269011-230p8rsf	530	20	results	result	NNS
cord-269011-230p8rsf	530	21	.	.	.
cord-269011-230p8rsf	531	1	For	for	IN
cord-269011-230p8rsf	531	2	IBV	IBV	NNP
cord-269011-230p8rsf	531	3	,	,	,
cord-269011-230p8rsf	531	4	deletion	deletion	NN
cord-269011-230p8rsf	531	5	mutagenesis	mutagenesis	NN
cord-269011-230p8rsf	531	6	of	of	IN
cord-269011-230p8rsf	531	7	a	a	DT
cord-269011-230p8rsf	531	8	defective	defective	JJ
cord-269011-230p8rsf	531	9	RNA	RNA	NNP
cord-269011-230p8rsf	531	10	led	lead	VBD
cord-269011-230p8rsf	531	11	to	to	IN
cord-269011-230p8rsf	531	12	the	the	DT
cord-269011-230p8rsf	531	13	conclusion	conclusion	NN
cord-269011-230p8rsf	531	14	that	that	IN
cord-269011-230p8rsf	531	15	only	only	RB
cord-269011-230p8rsf	531	16	the	the	DT
cord-269011-230p8rsf	531	17	sequences	sequence	NNS
cord-269011-230p8rsf	531	18	in	in	IN
cord-269011-230p8rsf	531	19	the	the	DT
cord-269011-230p8rsf	531	20	5	5	CD
cord-269011-230p8rsf	531	21	0	0	CD
cord-269011-230p8rsf	531	22	UTR	UTR	NNP
cord-269011-230p8rsf	531	23	and/or	and/or	CC
cord-269011-230p8rsf	531	24	a	a	DT
cord-269011-230p8rsf	531	25	region	region	NN
cord-269011-230p8rsf	531	26	of	of	IN
cord-269011-230p8rsf	531	27	the	the	DT
cord-269011-230p8rsf	531	28	3	3	CD
cord-269011-230p8rsf	531	29	0	0	CD
cord-269011-230p8rsf	531	30	UTR	UTR	NNP
cord-269011-230p8rsf	531	31	were	be	VBD
cord-269011-230p8rsf	531	32	specifically	specifically	RB
cord-269011-230p8rsf	531	33	required	require	VBN
cord-269011-230p8rsf	531	34	for	for	IN
cord-269011-230p8rsf	531	35	packaging	packaging	NN
cord-269011-230p8rsf	531	36	,	,	,
cord-269011-230p8rsf	531	37	although	although	IN
cord-269011-230p8rsf	531	38	parts	part	NNS
cord-269011-230p8rsf	531	39	of	of	IN
cord-269011-230p8rsf	531	40	the	the	DT
cord-269011-230p8rsf	531	41	pol1b	pol1b	JJ
cord-269011-230p8rsf	531	42	sequence	sequence	NN
cord-269011-230p8rsf	531	43	,	,	,
cord-269011-230p8rsf	531	44	but	but	CC
cord-269011-230p8rsf	531	45	not	not	RB
cord-269011-230p8rsf	531	46	any	any	DT
cord-269011-230p8rsf	531	47	part	part	NN
cord-269011-230p8rsf	531	48	in	in	IN
cord-269011-230p8rsf	531	49	particular	particular	JJ
cord-269011-230p8rsf	531	50	,	,	,
cord-269011-230p8rsf	531	51	also	also	RB
cord-269011-230p8rsf	531	52	enhanced	enhance	VBD
cord-269011-230p8rsf	531	53	the	the	DT
cord-269011-230p8rsf	531	54	efficiency	efficiency	NN
cord-269011-230p8rsf	531	55	(	(	-LRB-
cord-269011-230p8rsf	531	56	Dalton	Dalton	NNP
cord-269011-230p8rsf	531	57	et	et	NNP
cord-269011-230p8rsf	531	58	al	al	NNP
cord-269011-230p8rsf	531	59	.	.	NNP
cord-269011-230p8rsf	531	60	,	,	,
cord-269011-230p8rsf	531	61	2001	2001	CD
cord-269011-230p8rsf	531	62	)	)	-RRB-
cord-269011-230p8rsf	531	63	.	.	.
cord-269011-230p8rsf	532	1	Somewhat	somewhat	RB
cord-269011-230p8rsf	532	2	similar	similar	JJ
cord-269011-230p8rsf	532	3	conclusions	conclusion	NNS
cord-269011-230p8rsf	532	4	could	could	MD
cord-269011-230p8rsf	532	5	be	be	VB
cord-269011-230p8rsf	532	6	drawn	draw	VBN
cord-269011-230p8rsf	532	7	from	from	IN
cord-269011-230p8rsf	532	8	a	a	DT
cord-269011-230p8rsf	532	9	study	study	NN
cord-269011-230p8rsf	532	10	with	with	IN
cord-269011-230p8rsf	532	11	TGEV	TGEV	NNP
cord-269011-230p8rsf	533	1	(	(	-LRB-
cord-269011-230p8rsf	533	2	Izeta	Izeta	NNP
cord-269011-230p8rsf	533	3	et	et	FW
cord-269011-230p8rsf	533	4	al	al	NNP
cord-269011-230p8rsf	533	5	.	.	NNP
cord-269011-230p8rsf	533	6	,	,	,
cord-269011-230p8rsf	533	7	1999	1999	CD
cord-269011-230p8rsf	533	8	)	)	-RRB-
cord-269011-230p8rsf	533	9	.	.	.
cord-269011-230p8rsf	534	1	By	by	IN
cord-269011-230p8rsf	534	2	comparing	compare	VBG
cord-269011-230p8rsf	534	3	packaging	packaging	NN
cord-269011-230p8rsf	534	4	efficiencies	efficiency	NNS
cord-269011-230p8rsf	534	5	of	of	IN
cord-269011-230p8rsf	534	6	different	different	JJ
cord-269011-230p8rsf	534	7	defective	defective	JJ
cord-269011-230p8rsf	534	8	genomes	genome	NNS
cord-269011-230p8rsf	534	9	it	-PRON-	PRP
cord-269011-230p8rsf	534	10	was	be	VBD
cord-269011-230p8rsf	534	11	inferred	infer	VBN
cord-269011-230p8rsf	534	12	that	that	IN
cord-269011-230p8rsf	534	13	information	information	NN
cord-269011-230p8rsf	534	14	for	for	IN
cord-269011-230p8rsf	534	15	packaging	packaging	NN
cord-269011-230p8rsf	534	16	was	be	VBD
cord-269011-230p8rsf	534	17	present	present	JJ
cord-269011-230p8rsf	534	18	both	both	CC
cord-269011-230p8rsf	534	19	at	at	IN
cord-269011-230p8rsf	534	20	the	the	DT
cord-269011-230p8rsf	534	21	genomic	genomic	NN
cord-269011-230p8rsf	534	22	5	5	CD
cord-269011-230p8rsf	534	23	0	0	CD
cord-269011-230p8rsf	534	24	end	end	NN
cord-269011-230p8rsf	534	25	(	(	-LRB-
cord-269011-230p8rsf	534	26	about	about	RB
cord-269011-230p8rsf	534	27	1.0	1.0	CD
cord-269011-230p8rsf	534	28	kb	kb	NNP
cord-269011-230p8rsf	534	29	)	)	-RRB-
cord-269011-230p8rsf	534	30	and	and	CC
cord-269011-230p8rsf	534	31	in	in	IN
cord-269011-230p8rsf	534	32	parts	part	NNS
cord-269011-230p8rsf	534	33	of	of	IN
cord-269011-230p8rsf	534	34	pol1b	pol1b	NN
cord-269011-230p8rsf	534	35	.	.	.
cord-269011-230p8rsf	535	1	A	a	DT
cord-269011-230p8rsf	535	2	packaging	packaging	NN
cord-269011-230p8rsf	535	3	signal	signal	NN
cord-269011-230p8rsf	535	4	was	be	VBD
cord-269011-230p8rsf	535	5	subsequently	subsequently	RB
cord-269011-230p8rsf	535	6	mapped	map	VBN
cord-269011-230p8rsf	535	7	to	to	IN
cord-269011-230p8rsf	535	8	a	a	DT
cord-269011-230p8rsf	535	9	fragment	fragment	NN
cord-269011-230p8rsf	535	10	representing	represent	VBG
cord-269011-230p8rsf	535	11	the	the	DT
cord-269011-230p8rsf	535	12	5	5	CD
cord-269011-230p8rsf	535	13	0	0	CD
cord-269011-230p8rsf	535	14	terminal	terminal	NN
cord-269011-230p8rsf	535	15	649	649	CD
cord-269011-230p8rsf	535	16	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	535	17	of	of	IN
cord-269011-230p8rsf	535	18	the	the	DT
cord-269011-230p8rsf	535	19	genome	genome	NN
cord-269011-230p8rsf	535	20	by	by	IN
cord-269011-230p8rsf	535	21	inserting	insert	VBG
cord-269011-230p8rsf	535	22	a	a	DT
cord-269011-230p8rsf	535	23	series	series	NN
cord-269011-230p8rsf	535	24	of	of	IN
cord-269011-230p8rsf	535	25	overlapping	overlap	VBG
cord-269011-230p8rsf	535	26	segments	segment	NNS
cord-269011-230p8rsf	535	27	covering	cover	VBG
cord-269011-230p8rsf	535	28	a	a	DT
cord-269011-230p8rsf	535	29	stretch	stretch	NN
cord-269011-230p8rsf	535	30	of	of	IN
cord-269011-230p8rsf	535	31	about	about	RB
cord-269011-230p8rsf	535	32	2300	2300	CD
cord-269011-230p8rsf	535	33	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	535	34	from	from	IN
cord-269011-230p8rsf	535	35	the	the	DT
cord-269011-230p8rsf	535	36	5	5	CD
cord-269011-230p8rsf	535	37	0	0	CD
cord-269011-230p8rsf	535	38	end	end	NN
cord-269011-230p8rsf	535	39	of	of	IN
cord-269011-230p8rsf	535	40	the	the	DT
cord-269011-230p8rsf	535	41	genome	genome	NN
cord-269011-230p8rsf	535	42	into	into	IN
cord-269011-230p8rsf	535	43	an	an	DT
cord-269011-230p8rsf	535	44	mRNA	mRNA	NNP
cord-269011-230p8rsf	535	45	reporter	reporter	NN
cord-269011-230p8rsf	535	46	expression	expression	NN
cord-269011-230p8rsf	535	47	construct	construct	VB
cord-269011-230p8rsf	535	48	contained	contain	VBN
cord-269011-230p8rsf	535	49	within	within	IN
cord-269011-230p8rsf	535	50	a	a	DT
cord-269011-230p8rsf	535	51	defective	defective	JJ
cord-269011-230p8rsf	535	52	genome	genome	NN
cord-269011-230p8rsf	535	53	(	(	-LRB-
cord-269011-230p8rsf	535	54	Escors	Escors	NNP
cord-269011-230p8rsf	535	55	et	et	NNP
cord-269011-230p8rsf	535	56	al	al	NNP
cord-269011-230p8rsf	535	57	.	.	NNP
cord-269011-230p8rsf	535	58	,	,	,
cord-269011-230p8rsf	535	59	2003	2003	CD
cord-269011-230p8rsf	535	60	)	)	-RRB-
cord-269011-230p8rsf	535	61	;	;	:
cord-269011-230p8rsf	535	62	only	only	RB
cord-269011-230p8rsf	535	63	the	the	DT
cord-269011-230p8rsf	535	64	5	5	CD
cord-269011-230p8rsf	535	65	0	0	CD
cord-269011-230p8rsf	535	66	terminal	terminal	NN
cord-269011-230p8rsf	535	67	sequence	sequence	NN
cord-269011-230p8rsf	535	68	conferred	confer	VBN
cord-269011-230p8rsf	535	69	to	to	IN
cord-269011-230p8rsf	535	70	the	the	DT
cord-269011-230p8rsf	535	71	mRNA	mrna	NN
cord-269011-230p8rsf	536	1	the	the	DT
cord-269011-230p8rsf	536	2	ability	ability	NN
cord-269011-230p8rsf	536	3	to	to	TO
cord-269011-230p8rsf	536	4	become	become	VB
cord-269011-230p8rsf	536	5	packaged	package	VBN
cord-269011-230p8rsf	536	6	by	by	IN
cord-269011-230p8rsf	536	7	helper	helper	NN
cord-269011-230p8rsf	536	8	virus	virus	NN
cord-269011-230p8rsf	536	9	.	.	.
cord-269011-230p8rsf	537	1	It	-PRON-	PRP
cord-269011-230p8rsf	537	2	is	be	VBZ
cord-269011-230p8rsf	537	3	too	too	RB
cord-269011-230p8rsf	537	4	early	early	JJ
cord-269011-230p8rsf	537	5	to	to	TO
cord-269011-230p8rsf	537	6	conclude	conclude	VB
cord-269011-230p8rsf	537	7	that	that	IN
cord-269011-230p8rsf	537	8	the	the	DT
cord-269011-230p8rsf	537	9	apparently	apparently	RB
cord-269011-230p8rsf	537	10	contrasting	contrast	VBG
cord-269011-230p8rsf	537	11	results	result	NNS
cord-269011-230p8rsf	537	12	reflect	reflect	VBP
cord-269011-230p8rsf	537	13	true	true	JJ
cord-269011-230p8rsf	537	14	,	,	,
cord-269011-230p8rsf	537	15	fundamental	fundamental	JJ
cord-269011-230p8rsf	537	16	differences	difference	NNS
cord-269011-230p8rsf	537	17	in	in	IN
cord-269011-230p8rsf	537	18	encapsidation	encapsidation	NN
cord-269011-230p8rsf	537	19	strategies	strategy	NNS
cord-269011-230p8rsf	537	20	between	between	IN
cord-269011-230p8rsf	537	21	the	the	DT
cord-269011-230p8rsf	537	22	different	different	JJ
cord-269011-230p8rsf	537	23	(	(	-LRB-
cord-269011-230p8rsf	537	24	groups	group	NNS
cord-269011-230p8rsf	537	25	of	of	IN
cord-269011-230p8rsf	537	26	)	)	-RRB-
cord-269011-230p8rsf	537	27	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	537	28	.	.	.
cord-269011-230p8rsf	538	1	Although	although	IN
cord-269011-230p8rsf	538	2	the	the	DT
cord-269011-230p8rsf	538	3	overview	overview	NN
cord-269011-230p8rsf	538	4	may	may	MD
cord-269011-230p8rsf	538	5	suggest	suggest	VB
cord-269011-230p8rsf	538	6	the	the	DT
cord-269011-230p8rsf	538	7	existence	existence	NN
cord-269011-230p8rsf	538	8	of	of	IN
cord-269011-230p8rsf	538	9	different	different	JJ
cord-269011-230p8rsf	538	10	cis	cis	NNP
cord-269011-230p8rsf	538	11	-	-	HYPH
cord-269011-230p8rsf	538	12	acting	act	VBG
cord-269011-230p8rsf	538	13	signals	signal	NNS
cord-269011-230p8rsf	538	14	,	,	,
cord-269011-230p8rsf	538	15	the	the	DT
cord-269011-230p8rsf	538	16	data	datum	NNS
cord-269011-230p8rsf	538	17	still	still	RB
cord-269011-230p8rsf	538	18	allow	allow	VBP
cord-269011-230p8rsf	538	19	a	a	DT
cord-269011-230p8rsf	538	20	scenario	scenario	NN
cord-269011-230p8rsf	538	21	in	in	IN
cord-269011-230p8rsf	538	22	which	which	WDT
cord-269011-230p8rsf	538	23	multiple	multiple	JJ
cord-269011-230p8rsf	538	24	domains	domain	NNS
cord-269011-230p8rsf	538	25	in	in	IN
cord-269011-230p8rsf	538	26	the	the	DT
cord-269011-230p8rsf	538	27	genome	genome	NN
cord-269011-230p8rsf	538	28	are	be	VBP
cord-269011-230p8rsf	538	29	involved	involve	VBN
cord-269011-230p8rsf	538	30	cooperatively	cooperatively	RB
cord-269011-230p8rsf	538	31	,	,	,
cord-269011-230p8rsf	538	32	each	each	DT
cord-269011-230p8rsf	538	33	one	one	NN
cord-269011-230p8rsf	538	34	contributing	contribute	VBG
cord-269011-230p8rsf	538	35	differently	differently	RB
cord-269011-230p8rsf	538	36	to	to	IN
cord-269011-230p8rsf	538	37	(	(	-LRB-
cord-269011-230p8rsf	538	38	the	the	DT
cord-269011-230p8rsf	538	39	efficiency	efficiency	NN
cord-269011-230p8rsf	538	40	of	of	IN
cord-269011-230p8rsf	538	41	)	)	-RRB-
cord-269011-230p8rsf	538	42	the	the	DT
cord-269011-230p8rsf	538	43	encapsidation	encapsidation	NN
cord-269011-230p8rsf	538	44	process	process	NN
cord-269011-230p8rsf	538	45	.	.	.
cord-269011-230p8rsf	539	1	Such	such	JJ
cord-269011-230p8rsf	539	2	contributions	contribution	NNS
cord-269011-230p8rsf	539	3	would	would	MD
cord-269011-230p8rsf	539	4	not	not	RB
cord-269011-230p8rsf	539	5	necessarily	necessarily	RB
cord-269011-230p8rsf	539	6	concern	concern	NN
cord-269011-230p8rsf	539	7	N	n	CD
cord-269011-230p8rsf	539	8	protein	protein	NN
cord-269011-230p8rsf	539	9	binding	bind	VBG
cord-269011-230p8rsf	539	10	only	only	RB
cord-269011-230p8rsf	539	11	;	;	:
cord-269011-230p8rsf	539	12	the	the	DT
cord-269011-230p8rsf	539	13	exceptional	exceptional	JJ
cord-269011-230p8rsf	539	14	complexity	complexity	NN
cord-269011-230p8rsf	539	15	of	of	IN
cord-269011-230p8rsf	539	16	the	the	DT
cord-269011-230p8rsf	539	17	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	539	18	genome	genome	NN
cord-269011-230p8rsf	539	19	might	may	MD
cord-269011-230p8rsf	539	20	call	call	VB
cord-269011-230p8rsf	539	21	for	for	IN
cord-269011-230p8rsf	539	22	additional	additional	JJ
cord-269011-230p8rsf	539	23	provisions	provision	NNS
cord-269011-230p8rsf	539	24	,	,	,
cord-269011-230p8rsf	539	25	related	relate	VBN
cord-269011-230p8rsf	539	26	perhaps	perhaps	RB
cord-269011-230p8rsf	539	27	to	to	IN
cord-269011-230p8rsf	539	28	the	the	DT
cord-269011-230p8rsf	539	29	structuring	structuring	NN
cord-269011-230p8rsf	539	30	of	of	IN
cord-269011-230p8rsf	539	31	the	the	DT
cord-269011-230p8rsf	539	32	encapsidation	encapsidation	NN
cord-269011-230p8rsf	539	33	complex	complex	NN
cord-269011-230p8rsf	539	34	.	.	.
cord-269011-230p8rsf	540	1	Several	several	JJ
cord-269011-230p8rsf	540	2	observations	observation	NNS
cord-269011-230p8rsf	540	3	indeed	indeed	RB
cord-269011-230p8rsf	540	4	imply	imply	VBP
cord-269011-230p8rsf	540	5	the	the	DT
cord-269011-230p8rsf	540	6	involvement	involvement	NN
cord-269011-230p8rsf	540	7	of	of	IN
cord-269011-230p8rsf	540	8	multiple	multiple	JJ
cord-269011-230p8rsf	540	9	domains	domain	NNS
cord-269011-230p8rsf	540	10	.	.	.
cord-269011-230p8rsf	541	1	The	the	DT
cord-269011-230p8rsf	541	2	efficient	efficient	JJ
cord-269011-230p8rsf	541	3	rescue	rescue	NN
cord-269011-230p8rsf	541	4	,	,	,
cord-269011-230p8rsf	541	5	for	for	IN
cord-269011-230p8rsf	541	6	instance	instance	NN
cord-269011-230p8rsf	541	7	,	,	,
cord-269011-230p8rsf	541	8	of	of	IN
cord-269011-230p8rsf	541	9	a	a	DT
cord-269011-230p8rsf	541	10	BCoV	BCoV	NNP
cord-269011-230p8rsf	541	11	defective	defective	JJ
cord-269011-230p8rsf	541	12	genome	genome	NN
cord-269011-230p8rsf	541	13	(	(	-LRB-
cord-269011-230p8rsf	541	14	Drep	Drep	NNP
cord-269011-230p8rsf	541	15	)	)	-RRB-
cord-269011-230p8rsf	541	16	that	that	WDT
cord-269011-230p8rsf	541	17	completely	completely	RB
cord-269011-230p8rsf	541	18	lacks	lack	VBZ
cord-269011-230p8rsf	541	19	the	the	DT
cord-269011-230p8rsf	541	20	putative	putative	JJ
cord-269011-230p8rsf	541	21	69-nucleotide	69-nucleotide	CD
cord-269011-230p8rsf	541	22	packaging	packaging	NN
cord-269011-230p8rsf	541	23	signal	signal	NN
cord-269011-230p8rsf	541	24	entails	entail	VBZ
cord-269011-230p8rsf	541	25	the	the	DT
cord-269011-230p8rsf	541	26	participation	participation	NN
cord-269011-230p8rsf	541	27	of	of	IN
cord-269011-230p8rsf	541	28	additional	additional	JJ
cord-269011-230p8rsf	541	29	sequence(s	sequence(s	NN
cord-269011-230p8rsf	541	30	)	)	-RRB-
cord-269011-230p8rsf	542	1	(	(	-LRB-
cord-269011-230p8rsf	542	2	Chang	Chang	NNP
cord-269011-230p8rsf	542	3	and	and	CC
cord-269011-230p8rsf	542	4	Brian	Brian	NNP
cord-269011-230p8rsf	542	5	,	,	,
cord-269011-230p8rsf	542	6	1996	1996	CD
cord-269011-230p8rsf	542	7	;	;	:
cord-269011-230p8rsf	542	8	.	.	.
cord-269011-230p8rsf	543	1	Another	another	DT
cord-269011-230p8rsf	543	2	example	example	NN
cord-269011-230p8rsf	543	3	is	be	VBZ
cord-269011-230p8rsf	543	4	the	the	DT
cord-269011-230p8rsf	543	5	strongly	strongly	RB
cord-269011-230p8rsf	543	6	increased	increase	VBN
cord-269011-230p8rsf	543	7	rescue	rescue	NN
cord-269011-230p8rsf	543	8	of	of	IN
cord-269011-230p8rsf	543	9	an	an	DT
cord-269011-230p8rsf	543	10	otherwise	otherwise	RB
cord-269011-230p8rsf	543	11	poorly	poorly	RB
cord-269011-230p8rsf	543	12	packaged	package	VBN
cord-269011-230p8rsf	543	13	defective	defective	JJ
cord-269011-230p8rsf	543	14	TGEV	TGEV	NNS
cord-269011-230p8rsf	543	15	genome	genome	NN
cord-269011-230p8rsf	543	16	(	(	-LRB-
cord-269011-230p8rsf	543	17	M22	M22	NNP
cord-269011-230p8rsf	543	18	)	)	-RRB-
cord-269011-230p8rsf	543	19	due	due	IN
cord-269011-230p8rsf	543	20	to	to	IN
cord-269011-230p8rsf	543	21	the	the	DT
cord-269011-230p8rsf	543	22	presence	presence	NN
cord-269011-230p8rsf	543	23	of	of	IN
cord-269011-230p8rsf	543	24	about	about	RB
cord-269011-230p8rsf	543	25	4.1	4.1	CD
cord-269011-230p8rsf	543	26	kb	kb	NNS
cord-269011-230p8rsf	543	27	of	of	IN
cord-269011-230p8rsf	543	28	sequences	sequence	NNS
cord-269011-230p8rsf	543	29	derived	derive	VBN
cord-269011-230p8rsf	543	30	from	from	IN
cord-269011-230p8rsf	543	31	the	the	DT
cord-269011-230p8rsf	543	32	pol1b	pol1b	JJ
cord-269011-230p8rsf	543	33	gene	gene	NN
cord-269011-230p8rsf	543	34	(	(	-LRB-
cord-269011-230p8rsf	543	35	M62	M62	NNP
cord-269011-230p8rsf	543	36	)	)	-RRB-
cord-269011-230p8rsf	544	1	(	(	-LRB-
cord-269011-230p8rsf	544	2	Izeta	Izeta	NNP
cord-269011-230p8rsf	544	3	et	et	FW
cord-269011-230p8rsf	544	4	al	al	NNP
cord-269011-230p8rsf	544	5	.	.	NNP
cord-269011-230p8rsf	544	6	,	,	,
cord-269011-230p8rsf	544	7	1999	1999	CD
cord-269011-230p8rsf	544	8	)	)	-RRB-
cord-269011-230p8rsf	544	9	.	.	.
cord-269011-230p8rsf	545	1	There	there	EX
cord-269011-230p8rsf	545	2	is	be	VBZ
cord-269011-230p8rsf	545	3	no	no	DT
cord-269011-230p8rsf	545	4	direct	direct	JJ
cord-269011-230p8rsf	545	5	evidence	evidence	NN
cord-269011-230p8rsf	545	6	yet	yet	RB
cord-269011-230p8rsf	545	7	for	for	IN
cord-269011-230p8rsf	545	8	the	the	DT
cord-269011-230p8rsf	545	9	actual	actual	JJ
cord-269011-230p8rsf	545	10	functioning	functioning	NN
cord-269011-230p8rsf	545	11	of	of	IN
cord-269011-230p8rsf	545	12	the	the	DT
cord-269011-230p8rsf	545	13	presumed	presume	VBN
cord-269011-230p8rsf	545	14	packaging	packaging	NN
cord-269011-230p8rsf	545	15	signals	signal	NNS
cord-269011-230p8rsf	545	16	in	in	IN
cord-269011-230p8rsf	545	17	the	the	DT
cord-269011-230p8rsf	545	18	initiation	initiation	NN
cord-269011-230p8rsf	545	19	of	of	IN
cord-269011-230p8rsf	545	20	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	545	21	assembly	assembly	NNP
cord-269011-230p8rsf	545	22	.	.	.
cord-269011-230p8rsf	546	1	Binding	Binding	NNP
cord-269011-230p8rsf	546	2	of	of	IN
cord-269011-230p8rsf	546	3	N	n	CD
cord-269011-230p8rsf	546	4	protein	protein	NN
cord-269011-230p8rsf	546	5	to	to	IN
cord-269011-230p8rsf	546	6	these	these	DT
cord-269011-230p8rsf	546	7	signals	signal	NNS
cord-269011-230p8rsf	546	8	,	,	,
cord-269011-230p8rsf	546	9	the	the	DT
cord-269011-230p8rsf	546	10	first	first	JJ
cord-269011-230p8rsf	546	11	step	step	NN
cord-269011-230p8rsf	546	12	in	in	IN
cord-269011-230p8rsf	546	13	the	the	DT
cord-269011-230p8rsf	546	14	process	process	NN
cord-269011-230p8rsf	546	15	,	,	,
cord-269011-230p8rsf	546	16	has	have	VBZ
cord-269011-230p8rsf	546	17	so	so	RB
cord-269011-230p8rsf	546	18	far	far	RB
cord-269011-230p8rsf	546	19	been	be	VBN
cord-269011-230p8rsf	546	20	addressed	address	VBN
cord-269011-230p8rsf	546	21	only	only	RB
cord-269011-230p8rsf	546	22	for	for	IN
cord-269011-230p8rsf	546	23	the	the	DT
cord-269011-230p8rsf	546	24	69-nucleotide	69-nucleotide	CD
cord-269011-230p8rsf	546	25	sequence	sequence	NN
cord-269011-230p8rsf	546	26	of	of	IN
cord-269011-230p8rsf	546	27	MHV	MHV	NNP
cord-269011-230p8rsf	546	28	.	.	.
cord-269011-230p8rsf	547	1	Specific	specific	JJ
cord-269011-230p8rsf	547	2	binding	binding	NN
cord-269011-230p8rsf	547	3	to	to	IN
cord-269011-230p8rsf	547	4	RNA	RNA	NNP
cord-269011-230p8rsf	547	5	transcripts	transcript	NNS
cord-269011-230p8rsf	547	6	containing	contain	VBG
cord-269011-230p8rsf	547	7	this	this	DT
cord-269011-230p8rsf	547	8	sequence	sequence	NN
cord-269011-230p8rsf	547	9	was	be	VBD
cord-269011-230p8rsf	547	10	indeed	indeed	RB
cord-269011-230p8rsf	547	11	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	547	12	biochemically	biochemically	RB
cord-269011-230p8rsf	547	13	with	with	IN
cord-269011-230p8rsf	547	14	MHV	MHV	NNP
cord-269011-230p8rsf	547	15	N	N	NNP
cord-269011-230p8rsf	547	16	protein	protein	NN
cord-269011-230p8rsf	547	17	derived	derive	VBN
cord-269011-230p8rsf	547	18	from	from	IN
cord-269011-230p8rsf	547	19	infected	infected	JJ
cord-269011-230p8rsf	547	20	cells	cell	NNS
cord-269011-230p8rsf	547	21	,	,	,
cord-269011-230p8rsf	547	22	from	from	IN
cord-269011-230p8rsf	547	23	virions	virion	NNS
cord-269011-230p8rsf	547	24	,	,	,
cord-269011-230p8rsf	547	25	and	and	CC
cord-269011-230p8rsf	547	26	from	from	IN
cord-269011-230p8rsf	547	27	cells	cell	NNS
cord-269011-230p8rsf	547	28	expressing	express	VBG
cord-269011-230p8rsf	547	29	the	the	DT
cord-269011-230p8rsf	547	30	protein	protein	NN
cord-269011-230p8rsf	547	31	(	(	-LRB-
cord-269011-230p8rsf	547	32	Molenkamp	Molenkamp	NNP
cord-269011-230p8rsf	547	33	and	and	CC
cord-269011-230p8rsf	547	34	Spaan	Spaan	NNP
cord-269011-230p8rsf	547	35	,	,	,
cord-269011-230p8rsf	547	36	1997	1997	CD
cord-269011-230p8rsf	547	37	)	)	-RRB-
cord-269011-230p8rsf	547	38	.	.	.
cord-269011-230p8rsf	548	1	The	the	DT
cord-269011-230p8rsf	548	2	binding	bind	VBG
cord-269011-230p8rsf	548	3	efficiency	efficiency	NN
cord-269011-230p8rsf	548	4	,	,	,
cord-269011-230p8rsf	548	5	however	however	RB
cord-269011-230p8rsf	548	6	,	,	,
cord-269011-230p8rsf	548	7	appeared	appear	VBD
cord-269011-230p8rsf	548	8	to	to	TO
cord-269011-230p8rsf	548	9	be	be	VB
cord-269011-230p8rsf	548	10	relatively	relatively	RB
cord-269011-230p8rsf	548	11	weak	weak	JJ
cord-269011-230p8rsf	548	12	as	as	IN
cord-269011-230p8rsf	548	13	was	be	VBD
cord-269011-230p8rsf	548	14	shown	show	VBN
cord-269011-230p8rsf	548	15	by	by	IN
cord-269011-230p8rsf	548	16	comparing	compare	VBG
cord-269011-230p8rsf	548	17	N	n	CD
cord-269011-230p8rsf	548	18	protein	protein	NN
cord-269011-230p8rsf	548	19	binding	bind	VBG
cord-269011-230p8rsf	548	20	to	to	IN
cord-269011-230p8rsf	548	21	different	different	JJ
cord-269011-230p8rsf	548	22	parts	part	NNS
cord-269011-230p8rsf	548	23	of	of	IN
cord-269011-230p8rsf	548	24	a	a	DT
cord-269011-230p8rsf	548	25	packageable	packageable	JJ
cord-269011-230p8rsf	548	26	defective	defective	JJ
cord-269011-230p8rsf	548	27	genome	genome	NN
cord-269011-230p8rsf	548	28	(	(	-LRB-
cord-269011-230p8rsf	548	29	MIDI	MIDI	NNP
cord-269011-230p8rsf	548	30	-	-	HYPH
cord-269011-230p8rsf	548	31	C	C	NNP
cord-269011-230p8rsf	548	32	)	)	-RRB-
cord-269011-230p8rsf	548	33	.	.	.
cord-269011-230p8rsf	549	1	The	the	DT
cord-269011-230p8rsf	549	2	highest	high	JJS
cord-269011-230p8rsf	549	3	binding	binding	JJ
cord-269011-230p8rsf	549	4	efficiency	efficiency	NN
cord-269011-230p8rsf	549	5	was	be	VBD
cord-269011-230p8rsf	549	6	observed	observe	VBN
cord-269011-230p8rsf	549	7	with	with	IN
cord-269011-230p8rsf	549	8	an	an	DT
cord-269011-230p8rsf	549	9	RNA	RNA	NNP
cord-269011-230p8rsf	549	10	transcript	transcript	NN
cord-269011-230p8rsf	549	11	representing	represent	VBG
cord-269011-230p8rsf	549	12	about	about	IN
cord-269011-230p8rsf	549	13	1	1	CD
cord-269011-230p8rsf	549	14	kb	kb	NNS
cord-269011-230p8rsf	549	15	from	from	IN
cord-269011-230p8rsf	549	16	the	the	DT
cord-269011-230p8rsf	549	17	5	5	CD
cord-269011-230p8rsf	549	18	0	0	CD
cord-269011-230p8rsf	549	19	end	end	NN
cord-269011-230p8rsf	549	20	of	of	IN
cord-269011-230p8rsf	549	21	pol1a	pol1a	NN
cord-269011-230p8rsf	549	22	.	.	.
cord-269011-230p8rsf	550	1	Remarkably	remarkably	RB
cord-269011-230p8rsf	550	2	,	,	,
cord-269011-230p8rsf	550	3	not	not	RB
cord-269011-230p8rsf	550	4	even	even	RB
cord-269011-230p8rsf	550	5	removal	removal	NN
cord-269011-230p8rsf	550	6	of	of	IN
cord-269011-230p8rsf	550	7	the	the	DT
cord-269011-230p8rsf	550	8	packaging	packaging	NN
cord-269011-230p8rsf	550	9	signal	signal	NN
cord-269011-230p8rsf	550	10	from	from	IN
cord-269011-230p8rsf	550	11	MIDI	MIDI	NNP
cord-269011-230p8rsf	550	12	-	-	HYPH
cord-269011-230p8rsf	550	13	C	C	NNP
cord-269011-230p8rsf	550	14	RNA	RNA	NNP
cord-269011-230p8rsf	550	15	affected	affect	VBD
cord-269011-230p8rsf	550	16	binding	bind	VBG
cord-269011-230p8rsf	550	17	to	to	IN
cord-269011-230p8rsf	550	18	the	the	DT
cord-269011-230p8rsf	550	19	N	n	CD
cord-269011-230p8rsf	550	20	protein	protein	NN
cord-269011-230p8rsf	550	21	as	as	IN
cord-269011-230p8rsf	550	22	measured	measure	VBN
cord-269011-230p8rsf	550	23	in	in	IN
cord-269011-230p8rsf	550	24	the	the	DT
cord-269011-230p8rsf	550	25	filter	filter	NN
cord-269011-230p8rsf	550	26	-	-	HYPH
cord-269011-230p8rsf	550	27	binding	bind	VBG
cord-269011-230p8rsf	550	28	assay	assay	NN
cord-269011-230p8rsf	550	29	used	use	VBN
cord-269011-230p8rsf	550	30	.	.	.
cord-269011-230p8rsf	551	1	The	the	DT
cord-269011-230p8rsf	551	2	observations	observation	NNS
cord-269011-230p8rsf	551	3	indicate	indicate	VBP
cord-269011-230p8rsf	551	4	that	that	IN
cord-269011-230p8rsf	551	5	the	the	DT
cord-269011-230p8rsf	551	6	domain	domain	NN
cord-269011-230p8rsf	551	7	containing	contain	VBG
cord-269011-230p8rsf	551	8	the	the	DT
cord-269011-230p8rsf	551	9	69-nucleotide	69-nucleotide	CD
cord-269011-230p8rsf	551	10	sequence	sequence	NN
cord-269011-230p8rsf	551	11	does	do	VBZ
cord-269011-230p8rsf	551	12	not	not	RB
cord-269011-230p8rsf	551	13	function	function	VB
cord-269011-230p8rsf	551	14	as	as	IN
cord-269011-230p8rsf	551	15	a	a	DT
cord-269011-230p8rsf	551	16	packaging	packaging	NN
cord-269011-230p8rsf	551	17	signal	signal	NN
cord-269011-230p8rsf	551	18	in	in	IN
cord-269011-230p8rsf	551	19	the	the	DT
cord-269011-230p8rsf	551	20	conventional	conventional	JJ
cord-269011-230p8rsf	551	21	sense	sense	NN
cord-269011-230p8rsf	551	22	,	,	,
cord-269011-230p8rsf	551	23	adding	add	VBG
cord-269011-230p8rsf	551	24	further	further	JJ
cord-269011-230p8rsf	551	25	support	support	NN
cord-269011-230p8rsf	551	26	to	to	IN
cord-269011-230p8rsf	551	27	the	the	DT
cord-269011-230p8rsf	551	28	notion	notion	NN
cord-269011-230p8rsf	551	29	that	that	IN
cord-269011-230p8rsf	551	30	the	the	DT
cord-269011-230p8rsf	551	31	intricacies	intricacy	NNS
cord-269011-230p8rsf	551	32	of	of	IN
cord-269011-230p8rsf	551	33	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	551	34	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	551	35	assembly	assembly	NNP
cord-269011-230p8rsf	551	36	are	be	VBP
cord-269011-230p8rsf	551	37	complex	complex	JJ
cord-269011-230p8rsf	551	38	.	.	.
cord-269011-230p8rsf	552	1	Apart	apart	RB
cord-269011-230p8rsf	552	2	from	from	IN
cord-269011-230p8rsf	552	3	the	the	DT
cord-269011-230p8rsf	552	4	studies	study	NNS
cord-269011-230p8rsf	552	5	mentioned	mention	VBD
cord-269011-230p8rsf	552	6	,	,	,
cord-269011-230p8rsf	552	7	the	the	DT
cord-269011-230p8rsf	552	8	occurrence	occurrence	NN
cord-269011-230p8rsf	552	9	of	of	IN
cord-269011-230p8rsf	552	10	N	N	NNP
cord-269011-230p8rsf	552	11	-	-	HYPH
cord-269011-230p8rsf	552	12	RNA	RNA	NNP
cord-269011-230p8rsf	552	13	interactions	interaction	NNS
cord-269011-230p8rsf	552	14	has	have	VBZ
cord-269011-230p8rsf	552	15	been	be	VBN
cord-269011-230p8rsf	552	16	amply	amply	RB
cord-269011-230p8rsf	552	17	documented	document	VBN
cord-269011-230p8rsf	552	18	.	.	.
cord-269011-230p8rsf	553	1	This	this	DT
cord-269011-230p8rsf	553	2	is	be	VBZ
cord-269011-230p8rsf	553	3	not	not	RB
cord-269011-230p8rsf	553	4	surprising	surprising	JJ
cord-269011-230p8rsf	553	5	as	as	IN
cord-269011-230p8rsf	553	6	the	the	DT
cord-269011-230p8rsf	553	7	N	N	NNP
cord-269011-230p8rsf	553	8	protein	protein	NN
cord-269011-230p8rsf	553	9	has	have	VBZ
cord-269011-230p8rsf	553	10	been	be	VBN
cord-269011-230p8rsf	553	11	implicated	implicate	VBN
cord-269011-230p8rsf	553	12	in	in	IN
cord-269011-230p8rsf	553	13	several	several	JJ
cord-269011-230p8rsf	553	14	other	other	JJ
cord-269011-230p8rsf	553	15	processes	process	NNS
cord-269011-230p8rsf	553	16	that	that	WDT
cord-269011-230p8rsf	553	17	involve	involve	VBP
cord-269011-230p8rsf	553	18	interaction	interaction	NN
cord-269011-230p8rsf	553	19	with	with	IN
cord-269011-230p8rsf	553	20	RNA	RNA	NNP
cord-269011-230p8rsf	553	21	,	,	,
cord-269011-230p8rsf	553	22	such	such	JJ
cord-269011-230p8rsf	553	23	as	as	IN
cord-269011-230p8rsf	553	24	replication	replication	NN
cord-269011-230p8rsf	553	25	,	,	,
cord-269011-230p8rsf	553	26	transcription	transcription	NN
cord-269011-230p8rsf	553	27	,	,	,
cord-269011-230p8rsf	553	28	and	and	CC
cord-269011-230p8rsf	553	29	translation	translation	NN
cord-269011-230p8rsf	553	30	(	(	-LRB-
cord-269011-230p8rsf	553	31	Lai	Lai	NNP
cord-269011-230p8rsf	553	32	and	and	CC
cord-269011-230p8rsf	553	33	Cavanagh	Cavanagh	NNP
cord-269011-230p8rsf	553	34	,	,	,
cord-269011-230p8rsf	553	35	1997	1997	CD
cord-269011-230p8rsf	553	36	;	;	:
cord-269011-230p8rsf	553	37	see	see	VB
cord-269011-230p8rsf	553	38	also	also	RB
cord-269011-230p8rsf	553	39	Section	Section	NNP
cord-269011-230p8rsf	553	40	II.C	II.C	NNP
cord-269011-230p8rsf	553	41	)	)	-RRB-
cord-269011-230p8rsf	553	42	.	.	.
cord-269011-230p8rsf	554	1	As	as	IN
cord-269011-230p8rsf	554	2	the	the	DT
cord-269011-230p8rsf	554	3	relevance	relevance	NN
cord-269011-230p8rsf	554	4	of	of	IN
cord-269011-230p8rsf	554	5	these	these	DT
cord-269011-230p8rsf	554	6	interactions	interaction	NNS
cord-269011-230p8rsf	554	7	for	for	IN
cord-269011-230p8rsf	554	8	viral	viral	JJ
cord-269011-230p8rsf	554	9	assembly	assembly	NN
cord-269011-230p8rsf	554	10	is	be	VBZ
cord-269011-230p8rsf	554	11	generally	generally	RB
cord-269011-230p8rsf	554	12	unclear	unclear	JJ
cord-269011-230p8rsf	554	13	,	,	,
cord-269011-230p8rsf	554	14	a	a	DT
cord-269011-230p8rsf	554	15	brief	brief	JJ
cord-269011-230p8rsf	554	16	survey	survey	NN
cord-269011-230p8rsf	554	17	of	of	IN
cord-269011-230p8rsf	554	18	the	the	DT
cord-269011-230p8rsf	554	19	available	available	JJ
cord-269011-230p8rsf	554	20	information	information	NN
cord-269011-230p8rsf	554	21	is	be	VBZ
cord-269011-230p8rsf	554	22	included	include	VBN
cord-269011-230p8rsf	554	23	here	here	RB
cord-269011-230p8rsf	554	24	.	.	.
cord-269011-230p8rsf	555	1	In	in	IN
cord-269011-230p8rsf	555	2	addition	addition	NN
cord-269011-230p8rsf	555	3	,	,	,
cord-269011-230p8rsf	555	4	an	an	DT
cord-269011-230p8rsf	555	5	overview	overview	NN
cord-269011-230p8rsf	555	6	of	of	IN
cord-269011-230p8rsf	555	7	data	datum	NNS
cord-269011-230p8rsf	555	8	on	on	IN
cord-269011-230p8rsf	555	9	the	the	DT
cord-269011-230p8rsf	555	10	mapping	mapping	NN
cord-269011-230p8rsf	555	11	of	of	IN
cord-269011-230p8rsf	555	12	RNA	RNA	NNP
cord-269011-230p8rsf	555	13	interactions	interaction	NNS
cord-269011-230p8rsf	555	14	on	on	IN
cord-269011-230p8rsf	555	15	the	the	DT
cord-269011-230p8rsf	555	16	N	N	NNP
cord-269011-230p8rsf	555	17	polypeptide	polypeptide	NN
cord-269011-230p8rsf	555	18	is	be	VBZ
cord-269011-230p8rsf	555	19	schematically	schematically	RB
cord-269011-230p8rsf	555	20	presented	present	VBN
cord-269011-230p8rsf	555	21	in	in	IN
cord-269011-230p8rsf	555	22	Fig	Fig	NNP
cord-269011-230p8rsf	555	23	.	.	.
cord-269011-230p8rsf	556	1	6	6	LS
cord-269011-230p8rsf	556	2	.	.	.
cord-269011-230p8rsf	557	1	A	a	DT
cord-269011-230p8rsf	557	2	high	high	JJ
cord-269011-230p8rsf	557	3	-	-	HYPH
cord-269011-230p8rsf	557	4	affinity	affinity	NN
cord-269011-230p8rsf	557	5	interaction	interaction	NN
cord-269011-230p8rsf	557	6	between	between	IN
cord-269011-230p8rsf	557	7	the	the	DT
cord-269011-230p8rsf	557	8	N	N	NNP
cord-269011-230p8rsf	557	9	protein	protein	NN
cord-269011-230p8rsf	557	10	and	and	CC
cord-269011-230p8rsf	557	11	the	the	DT
cord-269011-230p8rsf	557	12	5	5	CD
cord-269011-230p8rsf	557	13	0	0	CD
cord-269011-230p8rsf	557	14	leader	leader	NN
cord-269011-230p8rsf	557	15	was	be	VBD
cord-269011-230p8rsf	557	16	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	557	17	for	for	IN
cord-269011-230p8rsf	557	18	MHV	MHV	NNP
cord-269011-230p8rsf	557	19	-	-	HYPH
cord-269011-230p8rsf	557	20	A59	A59	NNP
cord-269011-230p8rsf	557	21	.	.	.
cord-269011-230p8rsf	558	1	Using	use	VBG
cord-269011-230p8rsf	558	2	an	an	DT
cord-269011-230p8rsf	558	3	RNA	RNA	NNP
cord-269011-230p8rsf	558	4	overlay	overlay	NN
cord-269011-230p8rsf	558	5	protein	protein	NN
cord-269011-230p8rsf	558	6	blot	blot	NN
cord-269011-230p8rsf	558	7	assay	assay	NN
cord-269011-230p8rsf	558	8	and	and	CC
cord-269011-230p8rsf	558	9	various	various	JJ
cord-269011-230p8rsf	558	10	in	in	IN
cord-269011-230p8rsf	558	11	vitro	vitro	FW
cord-269011-230p8rsf	558	12	RNA	RNA	NNP
cord-269011-230p8rsf	558	13	transcripts	transcript	NNS
cord-269011-230p8rsf	558	14	,	,	,
cord-269011-230p8rsf	558	15	the	the	DT
cord-269011-230p8rsf	558	16	binding	binding	NN
cord-269011-230p8rsf	558	17	of	of	IN
cord-269011-230p8rsf	558	18	N	n	CD
cord-269011-230p8rsf	558	19	protein	protein	NN
cord-269011-230p8rsf	558	20	was	be	VBD
cord-269011-230p8rsf	558	21	localized	localize	VBN
cord-269011-230p8rsf	558	22	to	to	IN
cord-269011-230p8rsf	558	23	a	a	DT
cord-269011-230p8rsf	558	24	stretch	stretch	NN
cord-269011-230p8rsf	558	25	of	of	IN
cord-269011-230p8rsf	558	26	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	558	27	(	(	-LRB-
cord-269011-230p8rsf	558	28	nucleotides	nucleotide	NNS
cord-269011-230p8rsf	558	29	56	56	CD
cord-269011-230p8rsf	558	30	-	-	SYM
cord-269011-230p8rsf	558	31	65	65	CD
cord-269011-230p8rsf	558	32	)	)	-RRB-
cord-269011-230p8rsf	558	33	at	at	IN
cord-269011-230p8rsf	558	34	the	the	DT
cord-269011-230p8rsf	558	35	3	3	CD
cord-269011-230p8rsf	558	36	0	0	CD
cord-269011-230p8rsf	558	37	end	end	NN
cord-269011-230p8rsf	558	38	of	of	IN
cord-269011-230p8rsf	558	39	the	the	DT
cord-269011-230p8rsf	558	40	leader	leader	NN
cord-269011-230p8rsf	558	41	.	.	.
cord-269011-230p8rsf	559	1	The	the	DT
cord-269011-230p8rsf	559	2	stretch	stretch	NN
cord-269011-230p8rsf	559	3	included	include	VBD
cord-269011-230p8rsf	559	4	the	the	DT
cord-269011-230p8rsf	559	5	pentanucleotide	pentanucleotide	NN
cord-269011-230p8rsf	559	6	repeat	repeat	VB
cord-269011-230p8rsf	559	7	UCUAA	UCUAA	NNP
cord-269011-230p8rsf	559	8	now	now	RB
cord-269011-230p8rsf	559	9	known	know	VBN
cord-269011-230p8rsf	559	10	to	to	TO
cord-269011-230p8rsf	559	11	be	be	VB
cord-269011-230p8rsf	559	12	critical	critical	JJ
cord-269011-230p8rsf	559	13	for	for	IN
cord-269011-230p8rsf	559	14	transcription	transcription	NN
cord-269011-230p8rsf	559	15	.	.	.
cord-269011-230p8rsf	560	1	Biochemical	biochemical	JJ
cord-269011-230p8rsf	560	2	analyses	analysis	NNS
cord-269011-230p8rsf	560	3	of	of	IN
cord-269011-230p8rsf	560	4	the	the	DT
cord-269011-230p8rsf	560	5	interaction	interaction	NN
cord-269011-230p8rsf	560	6	measured	measure	VBD
cord-269011-230p8rsf	560	7	a	a	DT
cord-269011-230p8rsf	560	8	dissociation	dissociation	NN
cord-269011-230p8rsf	560	9	constant	constant	NN
cord-269011-230p8rsf	560	10	(	(	-LRB-
cord-269011-230p8rsf	560	11	K	K	NNP
cord-269011-230p8rsf	560	12	d	d	NNP
cord-269011-230p8rsf	560	13	)	)	-RRB-
cord-269011-230p8rsf	560	14	of	of	IN
cord-269011-230p8rsf	560	15	14	14	CD
cord-269011-230p8rsf	560	16	nM	nm	CD
cord-269011-230p8rsf	560	17	for	for	IN
cord-269011-230p8rsf	560	18	bacterially	bacterially	RB
cord-269011-230p8rsf	560	19	expressed	express	VBN
cord-269011-230p8rsf	560	20	MHV	MHV	NNP
cord-269011-230p8rsf	560	21	N	n	CD
cord-269011-230p8rsf	560	22	protein	protein	NN
cord-269011-230p8rsf	560	23	to	to	IN
cord-269011-230p8rsf	560	24	the	the	DT
cord-269011-230p8rsf	560	25	leader	leader	NN
cord-269011-230p8rsf	560	26	RNA	RNA	NNP
cord-269011-230p8rsf	560	27	(	(	-LRB-
cord-269011-230p8rsf	560	28	Nelson	Nelson	NNP
cord-269011-230p8rsf	560	29	et	et	NNP
cord-269011-230p8rsf	560	30	al	al	NNP
cord-269011-230p8rsf	560	31	.	.	NNP
cord-269011-230p8rsf	560	32	,	,	,
cord-269011-230p8rsf	560	33	2000	2000	CD
cord-269011-230p8rsf	560	34	)	)	-RRB-
cord-269011-230p8rsf	560	35	.	.	.
cord-269011-230p8rsf	561	1	Consistent	consistent	JJ
cord-269011-230p8rsf	561	2	with	with	IN
cord-269011-230p8rsf	561	3	the	the	DT
cord-269011-230p8rsf	561	4	presence	presence	NN
cord-269011-230p8rsf	561	5	of	of	IN
cord-269011-230p8rsf	561	6	a	a	DT
cord-269011-230p8rsf	561	7	leader	leader	NN
cord-269011-230p8rsf	561	8	at	at	IN
cord-269011-230p8rsf	561	9	the	the	DT
cord-269011-230p8rsf	561	10	5	5	CD
cord-269011-230p8rsf	561	11	0	0	CD
cord-269011-230p8rsf	561	12	end	end	NN
cord-269011-230p8rsf	561	13	of	of	IN
cord-269011-230p8rsf	561	14	all	all	DT
cord-269011-230p8rsf	561	15	viral	viral	JJ
cord-269011-230p8rsf	561	16	RNAs	rna	NNS
cord-269011-230p8rsf	561	17	,	,	,
cord-269011-230p8rsf	561	18	an	an	DT
cord-269011-230p8rsf	561	19	N	n	CD
cord-269011-230p8rsf	561	20	protein	protein	NN
cord-269011-230p8rsf	561	21	-	-	HYPH
cord-269011-230p8rsf	561	22	specific	specific	JJ
cord-269011-230p8rsf	561	23	monoclonal	monoclonal	JJ
cord-269011-230p8rsf	561	24	antibody	antibody	NN
cord-269011-230p8rsf	561	25	coimmunoprecipitated	coimmunoprecipitate	VBD
cord-269011-230p8rsf	561	26	genomic	genomic	JJ
cord-269011-230p8rsf	561	27	RNA	RNA	NNP
cord-269011-230p8rsf	561	28	as	as	RB
cord-269011-230p8rsf	561	29	well	well	RB
cord-269011-230p8rsf	561	30	as	as	IN
cord-269011-230p8rsf	561	31	the	the	DT
cord-269011-230p8rsf	561	32	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	561	33	RNAs	rna	NNS
cord-269011-230p8rsf	561	34	from	from	IN
cord-269011-230p8rsf	561	35	MHV	MHV	NNP
cord-269011-230p8rsf	561	36	-	-	HYPH
cord-269011-230p8rsf	561	37	infected	infect	VBN
cord-269011-230p8rsf	561	38	cells	cell	NNS
cord-269011-230p8rsf	561	39	.	.	.
cord-269011-230p8rsf	562	1	Similar	similar	JJ
cord-269011-230p8rsf	562	2	observations	observation	NNS
cord-269011-230p8rsf	562	3	were	be	VBD
cord-269011-230p8rsf	562	4	made	make	VBN
cord-269011-230p8rsf	562	5	for	for	IN
cord-269011-230p8rsf	562	6	BCoV	BCoV	NNP
cord-269011-230p8rsf	562	7	.	.	.
cord-269011-230p8rsf	563	1	Packaging	packaging	NN
cord-269011-230p8rsf	563	2	of	of	IN
cord-269011-230p8rsf	563	3	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	563	4	RNAs	RNAs	NNPS
cord-269011-230p8rsf	563	5	has	have	VBZ
cord-269011-230p8rsf	563	6	been	be	VBN
cord-269011-230p8rsf	563	7	reported	report	VBN
cord-269011-230p8rsf	563	8	for	for	IN
cord-269011-230p8rsf	563	9	TGEV	TGEV	NNP
cord-269011-230p8rsf	563	10	(	(	-LRB-
cord-269011-230p8rsf	563	11	Sethna	Sethna	NNP
cord-269011-230p8rsf	563	12	et	et	NNP
cord-269011-230p8rsf	563	13	al	al	NNP
cord-269011-230p8rsf	563	14	.	.	NNP
cord-269011-230p8rsf	563	15	,	,	,
cord-269011-230p8rsf	563	16	1991	1991	CD
cord-269011-230p8rsf	563	17	)	)	-RRB-
cord-269011-230p8rsf	563	18	,	,	,
cord-269011-230p8rsf	563	19	BCoV	BCoV	NNP
cord-269011-230p8rsf	563	20	(	(	-LRB-
cord-269011-230p8rsf	563	21	Hofmann	Hofmann	NNP
cord-269011-230p8rsf	563	22	et	et	NNP
cord-269011-230p8rsf	563	23	al	al	NNP
cord-269011-230p8rsf	563	24	.	.	NNP
cord-269011-230p8rsf	563	25	,	,	,
cord-269011-230p8rsf	563	26	1990	1990	CD
cord-269011-230p8rsf	563	27	)	)	-RRB-
cord-269011-230p8rsf	563	28	,	,	,
cord-269011-230p8rsf	563	29	and	and	CC
cord-269011-230p8rsf	563	30	IBV	IBV	NNP
cord-269011-230p8rsf	563	31	(	(	-LRB-
cord-269011-230p8rsf	563	32	Zhao	Zhao	NNP
cord-269011-230p8rsf	563	33	et	et	NNP
cord-269011-230p8rsf	563	34	al	al	NNP
cord-269011-230p8rsf	563	35	.	.	NNP
cord-269011-230p8rsf	563	36	,	,	,
cord-269011-230p8rsf	563	37	1993	1993	CD
cord-269011-230p8rsf	563	38	)	)	-RRB-
cord-269011-230p8rsf	564	1	but	but	CC
cord-269011-230p8rsf	564	2	not	not	RB
cord-269011-230p8rsf	564	3	for	for	IN
cord-269011-230p8rsf	564	4	MHV	MHV	NNP
cord-269011-230p8rsf	564	5	,	,	,
cord-269011-230p8rsf	565	1	suggesting	suggest	VBG
cord-269011-230p8rsf	565	2	that	that	IN
cord-269011-230p8rsf	565	3	their	-PRON-	PRP$
cord-269011-230p8rsf	565	4	incorporation	incorporation	NN
cord-269011-230p8rsf	565	5	is	be	VBZ
cord-269011-230p8rsf	565	6	not	not	RB
cord-269011-230p8rsf	565	7	mediated	mediate	VBN
cord-269011-230p8rsf	565	8	by	by	IN
cord-269011-230p8rsf	565	9	N	n	CD
cord-269011-230p8rsf	565	10	protein	protein	NN
cord-269011-230p8rsf	565	11	-	-	HYPH
cord-269011-230p8rsf	565	12	leader	leader	NN
cord-269011-230p8rsf	565	13	interaction	interaction	NN
cord-269011-230p8rsf	565	14	.	.	.
cord-269011-230p8rsf	566	1	Whereas	whereas	IN
cord-269011-230p8rsf	566	2	for	for	IN
cord-269011-230p8rsf	566	3	TGEV	TGEV	NNP
cord-269011-230p8rsf	566	4	and	and	CC
cord-269011-230p8rsf	566	5	IBV	IBV	NNP
cord-269011-230p8rsf	566	6	the	the	DT
cord-269011-230p8rsf	566	7	relative	relative	JJ
cord-269011-230p8rsf	566	8	packaging	packaging	NN
cord-269011-230p8rsf	566	9	of	of	IN
cord-269011-230p8rsf	566	10	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	566	11	RNAs	RNAs	NNPS
cord-269011-230p8rsf	566	12	was	be	VBD
cord-269011-230p8rsf	566	13	found	find	VBN
cord-269011-230p8rsf	566	14	to	to	TO
cord-269011-230p8rsf	566	15	be	be	VB
cord-269011-230p8rsf	566	16	inefficient	inefficient	JJ
cord-269011-230p8rsf	566	17	,	,	,
cord-269011-230p8rsf	566	18	genomic	genomic	JJ
cord-269011-230p8rsf	566	19	RNA	rna	NN
cord-269011-230p8rsf	566	20	appearing	appear	VBG
cord-269011-230p8rsf	566	21	in	in	IN
cord-269011-230p8rsf	566	22	virions	virion	NNS
cord-269011-230p8rsf	566	23	at	at	IN
cord-269011-230p8rsf	566	24	a	a	DT
cord-269011-230p8rsf	566	25	more	more	JJR
cord-269011-230p8rsf	566	26	than	than	IN
cord-269011-230p8rsf	566	27	10-fold	10-fold	JJ
cord-269011-230p8rsf	566	28	molar	molar	JJ
cord-269011-230p8rsf	566	29	excess	excess	NN
cord-269011-230p8rsf	566	30	over	over	IN
cord-269011-230p8rsf	566	31	any	any	DT
cord-269011-230p8rsf	566	32	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	566	33	RNA	RNA	NNP
cord-269011-230p8rsf	566	34	species	specie	NNS
cord-269011-230p8rsf	566	35	,	,	,
cord-269011-230p8rsf	567	1	the	the	DT
cord-269011-230p8rsf	567	2	BCoV	BCoV	NNP
cord-269011-230p8rsf	567	3	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	567	4	N	N	NNP
cord-269011-230p8rsf	567	5	and	and	CC
cord-269011-230p8rsf	567	6	M	M	NNP
cord-269011-230p8rsf	567	7	mRNAs	mRNAs	NNPS
cord-269011-230p8rsf	567	8	appeared	appear	VBD
cord-269011-230p8rsf	567	9	to	to	TO
cord-269011-230p8rsf	567	10	be	be	VB
cord-269011-230p8rsf	567	11	packaged	package	VBN
cord-269011-230p8rsf	567	12	as	as	RB
cord-269011-230p8rsf	567	13	abundantly	abundantly	RB
cord-269011-230p8rsf	567	14	as	as	IN
cord-269011-230p8rsf	567	15	the	the	DT
cord-269011-230p8rsf	567	16	genome	genome	NN
cord-269011-230p8rsf	568	1	(	(	-LRB-
cord-269011-230p8rsf	568	2	Hofmann	Hofmann	NNP
cord-269011-230p8rsf	568	3	et	et	NNP
cord-269011-230p8rsf	568	4	al	al	NNP
cord-269011-230p8rsf	568	5	.	.	NNP
cord-269011-230p8rsf	568	6	,	,	,
cord-269011-230p8rsf	568	7	1990	1990	CD
cord-269011-230p8rsf	568	8	)	)	-RRB-
cord-269011-230p8rsf	568	9	.	.	.
cord-269011-230p8rsf	569	1	A	a	DT
cord-269011-230p8rsf	569	2	reevaluation	reevaluation	NN
cord-269011-230p8rsf	569	3	for	for	IN
cord-269011-230p8rsf	569	4	TGEV	TGEV	NNP
cord-269011-230p8rsf	569	5	revealed	reveal	VBD
cord-269011-230p8rsf	569	6	that	that	IN
cord-269011-230p8rsf	569	7	the	the	DT
cord-269011-230p8rsf	569	8	detection	detection	NN
cord-269011-230p8rsf	569	9	of	of	IN
cord-269011-230p8rsf	569	10	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	569	11	RNAs	RNAs	NNPS
cord-269011-230p8rsf	569	12	in	in	IN
cord-269011-230p8rsf	569	13	virions	virion	NNS
cord-269011-230p8rsf	569	14	was	be	VBD
cord-269011-230p8rsf	569	15	related	relate	VBN
cord-269011-230p8rsf	569	16	to	to	IN
cord-269011-230p8rsf	569	17	the	the	DT
cord-269011-230p8rsf	569	18	purity	purity	NN
cord-269011-230p8rsf	569	19	of	of	IN
cord-269011-230p8rsf	569	20	virus	virus	NN
cord-269011-230p8rsf	569	21	preparations	preparation	NNS
cord-269011-230p8rsf	569	22	,	,	,
cord-269011-230p8rsf	569	23	indicating	indicate	VBG
cord-269011-230p8rsf	569	24	that	that	IN
cord-269011-230p8rsf	569	25	mRNAs	mrnas	PRP
cord-269011-230p8rsf	569	26	were	be	VBD
cord-269011-230p8rsf	569	27	not	not	RB
cord-269011-230p8rsf	569	28	specifically	specifically	RB
cord-269011-230p8rsf	569	29	encapsidated	encapsidate	VBN
cord-269011-230p8rsf	569	30	(	(	-LRB-
cord-269011-230p8rsf	569	31	Escors	Escors	NNP
cord-269011-230p8rsf	569	32	et	et	NNP
cord-269011-230p8rsf	569	33	al	al	NNP
cord-269011-230p8rsf	569	34	.	.	NNP
cord-269011-230p8rsf	569	35	,	,	,
cord-269011-230p8rsf	569	36	2003	2003	CD
cord-269011-230p8rsf	569	37	)	)	-RRB-
cord-269011-230p8rsf	569	38	.	.	.
cord-269011-230p8rsf	570	1	Besides	besides	IN
cord-269011-230p8rsf	570	2	the	the	DT
cord-269011-230p8rsf	570	3	leader	leader	NN
cord-269011-230p8rsf	570	4	,	,	,
cord-269011-230p8rsf	570	5	the	the	DT
cord-269011-230p8rsf	570	6	N	N	NNP
cord-269011-230p8rsf	570	7	protein	protein	NN
cord-269011-230p8rsf	570	8	has	have	VBZ
cord-269011-230p8rsf	570	9	been	be	VBN
cord-269011-230p8rsf	570	10	found	find	VBN
cord-269011-230p8rsf	570	11	to	to	TO
cord-269011-230p8rsf	570	12	bind	bind	VB
cord-269011-230p8rsf	570	13	to	to	IN
cord-269011-230p8rsf	570	14	other	other	JJ
cord-269011-230p8rsf	570	15	parts	part	NNS
cord-269011-230p8rsf	570	16	of	of	IN
cord-269011-230p8rsf	570	17	the	the	DT
cord-269011-230p8rsf	570	18	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	570	19	genome	genome	NN
cord-269011-230p8rsf	570	20	.	.	.
cord-269011-230p8rsf	571	1	In	in	IN
cord-269011-230p8rsf	571	2	addition	addition	NN
cord-269011-230p8rsf	571	3	to	to	IN
cord-269011-230p8rsf	571	4	the	the	DT
cord-269011-230p8rsf	571	5	binding	binding	NN
cord-269011-230p8rsf	571	6	site	site	NN
cord-269011-230p8rsf	571	7	in	in	IN
cord-269011-230p8rsf	571	8	the	the	DT
cord-269011-230p8rsf	571	9	MHV	MHV	NNP
cord-269011-230p8rsf	571	10	FIG	FIG	NNP
cord-269011-230p8rsf	571	11	6	6	CD
cord-269011-230p8rsf	571	12	.	.	.
cord-269011-230p8rsf	572	1	Structural	structural	JJ
cord-269011-230p8rsf	572	2	organization	organization	NN
cord-269011-230p8rsf	572	3	of	of	IN
cord-269011-230p8rsf	572	4	the	the	DT
cord-269011-230p8rsf	572	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	572	6	N	n	CD
cord-269011-230p8rsf	572	7	protein	protein	NN
cord-269011-230p8rsf	572	8	.	.	.
cord-269011-230p8rsf	573	1	Common	common	JJ
cord-269011-230p8rsf	573	2	features	feature	NNS
cord-269011-230p8rsf	573	3	and	and	CC
cord-269011-230p8rsf	573	4	their	-PRON-	PRP$
cord-269011-230p8rsf	573	5	distribution	distribution	NN
cord-269011-230p8rsf	573	6	along	along	IN
cord-269011-230p8rsf	573	7	the	the	DT
cord-269011-230p8rsf	573	8	polypeptide	polypeptide	NN
cord-269011-230p8rsf	573	9	chain	chain	NN
cord-269011-230p8rsf	573	10	are	be	VBP
cord-269011-230p8rsf	573	11	shown	show	VBN
cord-269011-230p8rsf	573	12	schematically	schematically	RB
cord-269011-230p8rsf	573	13	.	.	.
cord-269011-230p8rsf	574	1	The	the	DT
cord-269011-230p8rsf	574	2	hatched	hatch	VBN
cord-269011-230p8rsf	574	3	box	box	NN
cord-269011-230p8rsf	574	4	indicates	indicate	VBZ
cord-269011-230p8rsf	574	5	the	the	DT
cord-269011-230p8rsf	574	6	most	most	RBS
cord-269011-230p8rsf	574	7	conserved	conserved	JJ
cord-269011-230p8rsf	574	8	part	part	NN
cord-269011-230p8rsf	574	9	of	of	IN
cord-269011-230p8rsf	574	10	the	the	DT
cord-269011-230p8rsf	574	11	N	N	NNP
cord-269011-230p8rsf	574	12	protein	protein	NN
cord-269011-230p8rsf	574	13	,	,	,
cord-269011-230p8rsf	574	14	with	with	IN
cord-269011-230p8rsf	574	15	a	a	DT
cord-269011-230p8rsf	574	16	high	high	JJ
cord-269011-230p8rsf	574	17	proportion	proportion	NN
cord-269011-230p8rsf	574	18	of	of	IN
cord-269011-230p8rsf	574	19	aromatic	aromatic	JJ
cord-269011-230p8rsf	574	20	residues	residue	NNS
cord-269011-230p8rsf	574	21	.	.	.
cord-269011-230p8rsf	575	1	The	the	DT
cord-269011-230p8rsf	575	2	N	N	NNP
cord-269011-230p8rsf	575	3	protein	protein	NN
cord-269011-230p8rsf	575	4	contains	contain	VBZ
cord-269011-230p8rsf	575	5	many	many	JJ
cord-269011-230p8rsf	575	6	basic	basic	JJ
cord-269011-230p8rsf	575	7	residues	residue	NNS
cord-269011-230p8rsf	575	8	throughout	throughout	IN
cord-269011-230p8rsf	575	9	the	the	DT
cord-269011-230p8rsf	575	10	polypeptide	polypeptide	NN
cord-269011-230p8rsf	575	11	,	,	,
cord-269011-230p8rsf	575	12	but	but	CC
cord-269011-230p8rsf	575	13	with	with	IN
cord-269011-230p8rsf	575	14	particular	particular	JJ
cord-269011-230p8rsf	575	15	clustering	clustering	NN
cord-269011-230p8rsf	575	16	in	in	IN
cord-269011-230p8rsf	575	17	two	two	CD
cord-269011-230p8rsf	575	18	regions	region	NNS
cord-269011-230p8rsf	575	19	(	(	-LRB-
cord-269011-230p8rsf	575	20	þþþ	þþþ	NNP
cord-269011-230p8rsf	575	21	)	)	-RRB-
cord-269011-230p8rsf	575	22	.	.	.
cord-269011-230p8rsf	576	1	The	the	DT
cord-269011-230p8rsf	576	2	upstream	upstream	JJ
cord-269011-230p8rsf	576	3	cluster	cluster	NN
cord-269011-230p8rsf	576	4	contains	contain	VBZ
cord-269011-230p8rsf	576	5	a	a	DT
cord-269011-230p8rsf	576	6	serine	serine	NN
cord-269011-230p8rsf	576	7	/	/	SYM
cord-269011-230p8rsf	576	8	arginine	arginine	NN
cord-269011-230p8rsf	576	9	-	-	HYPH
cord-269011-230p8rsf	576	10	rich	rich	JJ
cord-269011-230p8rsf	576	11	region	region	NN
cord-269011-230p8rsf	576	12	(	(	-LRB-
cord-269011-230p8rsf	576	13	S	s	NN
cord-269011-230p8rsf	576	14	/	/	SYM
cord-269011-230p8rsf	576	15	R	r	NN
cord-269011-230p8rsf	576	16	)	)	-RRB-
cord-269011-230p8rsf	576	17	.	.	.
cord-269011-230p8rsf	577	1	The	the	DT
cord-269011-230p8rsf	577	2	carboxy	carboxy	JJ
cord-269011-230p8rsf	577	3	terminus	terminus	NN
cord-269011-230p8rsf	577	4	,	,	,
cord-269011-230p8rsf	577	5	which	which	WDT
cord-269011-230p8rsf	577	6	contains	contain	VBZ
cord-269011-230p8rsf	577	7	a	a	DT
cord-269011-230p8rsf	577	8	high	high	JJ
cord-269011-230p8rsf	577	9	proportion	proportion	NN
cord-269011-230p8rsf	577	10	of	of	IN
cord-269011-230p8rsf	577	11	acidic	acidic	JJ
cord-269011-230p8rsf	577	12	residues	residue	NNS
cord-269011-230p8rsf	577	13	,	,	,
cord-269011-230p8rsf	577	14	is	be	VBZ
cord-269011-230p8rsf	577	15	also	also	RB
cord-269011-230p8rsf	577	16	indicated	indicate	VBN
cord-269011-230p8rsf	577	17	(	(	-LRB-
cord-269011-230p8rsf	577	18	ÀÀÀ	ÀÀÀ	NNP
cord-269011-230p8rsf	577	19	)	)	-RRB-
cord-269011-230p8rsf	577	20	.	.	.
cord-269011-230p8rsf	578	1	The	the	DT
cord-269011-230p8rsf	578	2	bars	bar	NNS
cord-269011-230p8rsf	578	3	indicate	indicate	VBP
cord-269011-230p8rsf	578	4	parts	part	NNS
cord-269011-230p8rsf	578	5	of	of	IN
cord-269011-230p8rsf	578	6	the	the	DT
cord-269011-230p8rsf	578	7	N	n	CD
cord-269011-230p8rsf	578	8	protein	protein	NN
cord-269011-230p8rsf	578	9	that	that	WDT
cord-269011-230p8rsf	578	10	have	have	VBP
cord-269011-230p8rsf	578	11	been	be	VBN
cord-269011-230p8rsf	578	12	implicated	implicate	VBN
cord-269011-230p8rsf	578	13	in	in	IN
cord-269011-230p8rsf	578	14	N	N	NNP
cord-269011-230p8rsf	578	15	-	-	HYPH
cord-269011-230p8rsf	578	16	N	N	NNP
cord-269011-230p8rsf	578	17	and	and	CC
cord-269011-230p8rsf	578	18	N	N	NNP
cord-269011-230p8rsf	578	19	-	-	HYPH
cord-269011-230p8rsf	578	20	RNA	RNA	NNP
cord-269011-230p8rsf	578	21	interaction	interaction	NN
cord-269011-230p8rsf	578	22	.	.	.
cord-269011-230p8rsf	579	1	Furthermore	furthermore	RB
cord-269011-230p8rsf	579	2	,	,	,
cord-269011-230p8rsf	579	3	the	the	DT
cord-269011-230p8rsf	579	4	location	location	NN
cord-269011-230p8rsf	579	5	of	of	IN
cord-269011-230p8rsf	579	6	the	the	DT
cord-269011-230p8rsf	579	7	deletion	deletion	NN
cord-269011-230p8rsf	579	8	in	in	IN
cord-269011-230p8rsf	579	9	the	the	DT
cord-269011-230p8rsf	579	10	MHV	MHV	NNP
cord-269011-230p8rsf	579	11	-	-	HYPH
cord-269011-230p8rsf	579	12	A59	A59	NNP
cord-269011-230p8rsf	579	13	mutant	mutant	NN
cord-269011-230p8rsf	579	14	Alb4	Alb4	NNP
cord-269011-230p8rsf	579	15	(	(	-LRB-
cord-269011-230p8rsf	579	16	D	D	NNP
cord-269011-230p8rsf	579	17	)	)	-RRB-
cord-269011-230p8rsf	579	18	is	be	VBZ
cord-269011-230p8rsf	579	19	indicated	indicate	VBN
cord-269011-230p8rsf	579	20	as	as	RB
cord-269011-230p8rsf	579	21	well	well	RB
cord-269011-230p8rsf	579	22	as	as	IN
cord-269011-230p8rsf	579	23	the	the	DT
cord-269011-230p8rsf	579	24	domain	domain	NN
cord-269011-230p8rsf	579	25	where	where	WRB
cord-269011-230p8rsf	579	26	second	second	JJ
cord-269011-230p8rsf	579	27	-	-	HYPH
cord-269011-230p8rsf	579	28	site	site	NN
cord-269011-230p8rsf	579	29	mutations	mutation	NNS
cord-269011-230p8rsf	579	30	in	in	IN
cord-269011-230p8rsf	579	31	revertant	revertant	NN
cord-269011-230p8rsf	579	32	viruses	virus	NNS
cord-269011-230p8rsf	579	33	of	of	IN
cord-269011-230p8rsf	579	34	Alb4	Alb4	NNP
cord-269011-230p8rsf	579	35	are	be	VBP
cord-269011-230p8rsf	579	36	mapped	map	VBN
cord-269011-230p8rsf	579	37	.	.	.
cord-269011-230p8rsf	580	1	Finally	finally	RB
cord-269011-230p8rsf	580	2	,	,	,
cord-269011-230p8rsf	580	3	the	the	DT
cord-269011-230p8rsf	580	4	parts	part	NNS
cord-269011-230p8rsf	580	5	of	of	IN
cord-269011-230p8rsf	580	6	the	the	DT
cord-269011-230p8rsf	580	7	N	n	CD
cord-269011-230p8rsf	580	8	protein	protein	NN
cord-269011-230p8rsf	580	9	that	that	WDT
cord-269011-230p8rsf	580	10	could	could	MD
cord-269011-230p8rsf	580	11	not	not	RB
cord-269011-230p8rsf	580	12	be	be	VB
cord-269011-230p8rsf	580	13	transferred	transfer	VBN
cord-269011-230p8rsf	580	14	from	from	IN
cord-269011-230p8rsf	580	15	BCV	BCV	NNP
cord-269011-230p8rsf	580	16	into	into	IN
cord-269011-230p8rsf	580	17	the	the	DT
cord-269011-230p8rsf	580	18	MHV	MHV	NNP
cord-269011-230p8rsf	580	19	genome	genome	NN
cord-269011-230p8rsf	580	20	are	be	VBP
cord-269011-230p8rsf	580	21	marked	mark	VBN
cord-269011-230p8rsf	580	22	.	.	.
cord-269011-230p8rsf	581	1	References	reference	NNS
cord-269011-230p8rsf	581	2	are	be	VBP
cord-269011-230p8rsf	581	3	included	include	VBN
cord-269011-230p8rsf	581	4	in	in	IN
cord-269011-230p8rsf	581	5	the	the	DT
cord-269011-230p8rsf	581	6	figure	figure	NN
cord-269011-230p8rsf	581	7	.	.	.
cord-269011-230p8rsf	582	1	pol1a	pol1a	NNP
cord-269011-230p8rsf	582	2	gene	gene	NN
cord-269011-230p8rsf	582	3	mentioned	mention	VBD
cord-269011-230p8rsf	582	4	previously	previously	RB
cord-269011-230p8rsf	582	5	,	,	,
cord-269011-230p8rsf	582	6	a	a	DT
cord-269011-230p8rsf	582	7	high	high	JJ
cord-269011-230p8rsf	582	8	-	-	HYPH
cord-269011-230p8rsf	582	9	efficiency	efficiency	NN
cord-269011-230p8rsf	582	10	binding	binding	NN
cord-269011-230p8rsf	582	11	site	site	NN
cord-269011-230p8rsf	582	12	was	be	VBD
cord-269011-230p8rsf	582	13	identified	identify	VBN
cord-269011-230p8rsf	582	14	by	by	IN
cord-269011-230p8rsf	582	15	the	the	DT
cord-269011-230p8rsf	582	16	same	same	JJ
cord-269011-230p8rsf	582	17	authors	author	NNS
cord-269011-230p8rsf	582	18	in	in	IN
cord-269011-230p8rsf	582	19	the	the	DT
cord-269011-230p8rsf	582	20	3	3	CD
cord-269011-230p8rsf	582	21	0	0	CD
cord-269011-230p8rsf	582	22	half	half	NN
cord-269011-230p8rsf	582	23	of	of	IN
cord-269011-230p8rsf	582	24	the	the	DT
cord-269011-230p8rsf	582	25	N	n	CD
cord-269011-230p8rsf	582	26	gene	gene	NN
cord-269011-230p8rsf	582	27	of	of	IN
cord-269011-230p8rsf	582	28	both	both	CC
cord-269011-230p8rsf	582	29	MHV	MHV	NNP
cord-269011-230p8rsf	582	30	and	and	CC
cord-269011-230p8rsf	582	31	BCoV	BCoV	NNP
cord-269011-230p8rsf	582	32	.	.	.
cord-269011-230p8rsf	583	1	The	the	DT
cord-269011-230p8rsf	583	2	IBV	IBV	NNP
cord-269011-230p8rsf	583	3	N	N	NNP
cord-269011-230p8rsf	583	4	protein	protein	NN
cord-269011-230p8rsf	583	5	was	be	VBD
cord-269011-230p8rsf	583	6	shown	show	VBN
cord-269011-230p8rsf	583	7	to	to	TO
cord-269011-230p8rsf	583	8	bind	bind	VB
cord-269011-230p8rsf	583	9	sequences	sequence	NNS
cord-269011-230p8rsf	583	10	in	in	IN
cord-269011-230p8rsf	583	11	the	the	DT
cord-269011-230p8rsf	583	12	3	3	CD
cord-269011-230p8rsf	583	13	0	0	CD
cord-269011-230p8rsf	583	14	terminal	terminal	NN
cord-269011-230p8rsf	583	15	UTR	UTR	NNP
cord-269011-230p8rsf	583	16	of	of	IN
cord-269011-230p8rsf	583	17	the	the	DT
cord-269011-230p8rsf	583	18	genome	genome	NN
cord-269011-230p8rsf	584	1	(	(	-LRB-
cord-269011-230p8rsf	584	2	Zhou	Zhou	NNP
cord-269011-230p8rsf	584	3	et	et	NNP
cord-269011-230p8rsf	584	4	al	al	NNP
cord-269011-230p8rsf	584	5	.	.	NNP
cord-269011-230p8rsf	584	6	,	,	,
cord-269011-230p8rsf	584	7	1996	1996	CD
cord-269011-230p8rsf	584	8	)	)	-RRB-
cord-269011-230p8rsf	584	9	.	.	.
cord-269011-230p8rsf	585	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	585	2	N	n	CD
cord-269011-230p8rsf	585	3	proteins	protein	NNS
cord-269011-230p8rsf	585	4	do	do	VBP
cord-269011-230p8rsf	585	5	not	not	RB
cord-269011-230p8rsf	585	6	contain	contain	VB
cord-269011-230p8rsf	585	7	sequence	sequence	NN
cord-269011-230p8rsf	585	8	motifs	motif	NNS
cord-269011-230p8rsf	585	9	typically	typically	RB
cord-269011-230p8rsf	585	10	found	find	VBN
cord-269011-230p8rsf	585	11	in	in	IN
cord-269011-230p8rsf	585	12	other	other	JJ
cord-269011-230p8rsf	585	13	RNA	RNA	NNP
cord-269011-230p8rsf	585	14	-	-	HYPH
cord-269011-230p8rsf	585	15	binding	bind	VBG
cord-269011-230p8rsf	585	16	proteins	protein	NNS
cord-269011-230p8rsf	585	17	.	.	.
cord-269011-230p8rsf	586	1	They	-PRON-	PRP
cord-269011-230p8rsf	586	2	appear	appear	VBP
cord-269011-230p8rsf	586	3	to	to	TO
cord-269011-230p8rsf	586	4	bind	bind	VB
cord-269011-230p8rsf	586	5	RNA	RNA	NNP
cord-269011-230p8rsf	586	6	both	both	CC
cord-269011-230p8rsf	586	7	nonspecifically	nonspecifically	RB
cord-269011-230p8rsf	586	8	(	(	-LRB-
cord-269011-230p8rsf	586	9	Masters	master	NNS
cord-269011-230p8rsf	586	10	,	,	,
cord-269011-230p8rsf	586	11	1992	1992	CD
cord-269011-230p8rsf	586	12	;	;	:
cord-269011-230p8rsf	586	13	Robbins	Robbins	NNP
cord-269011-230p8rsf	586	14	et	et	NNP
cord-269011-230p8rsf	586	15	al	al	NNP
cord-269011-230p8rsf	586	16	.	.	NNP
cord-269011-230p8rsf	586	17	,	,	,
cord-269011-230p8rsf	586	18	1986	1986	CD
cord-269011-230p8rsf	586	19	)	)	-RRB-
cord-269011-230p8rsf	586	20	and	and	CC
cord-269011-230p8rsf	586	21	in	in	IN
cord-269011-230p8rsf	586	22	a	a	DT
cord-269011-230p8rsf	586	23	sequencespecific	sequencespecific	JJ
cord-269011-230p8rsf	586	24	way	way	NN
cord-269011-230p8rsf	586	25	Nelson	Nelson	NNP
cord-269011-230p8rsf	586	26	and	and	CC
cord-269011-230p8rsf	586	27	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	586	28	,	,	,
cord-269011-230p8rsf	586	29	1993	1993	CD
cord-269011-230p8rsf	586	30	;	;	:
cord-269011-230p8rsf	587	1	Nelson	Nelson	NNP
cord-269011-230p8rsf	587	2	et	et	NNP
cord-269011-230p8rsf	587	3	al	al	NNP
cord-269011-230p8rsf	587	4	.	.	NNP
cord-269011-230p8rsf	587	5	,	,	,
cord-269011-230p8rsf	587	6	2000	2000	CD
cord-269011-230p8rsf	587	7	;	;	:
cord-269011-230p8rsf	587	8	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	587	9	et	et	NNP
cord-269011-230p8rsf	587	10	al	al	NNP
cord-269011-230p8rsf	587	11	.	.	NNP
cord-269011-230p8rsf	587	12	,	,	,
cord-269011-230p8rsf	587	13	1992	1992	CD
cord-269011-230p8rsf	587	14	)	)	-RRB-
cord-269011-230p8rsf	587	15	.	.	.
cord-269011-230p8rsf	588	1	Non	non	JJ
cord-269011-230p8rsf	588	2	-	-	JJ
cord-269011-230p8rsf	588	3	sequence	sequence	NN
cord-269011-230p8rsf	588	4	-	-	HYPH
cord-269011-230p8rsf	588	5	specific	specific	JJ
cord-269011-230p8rsf	588	6	RNA	RNA	NNP
cord-269011-230p8rsf	588	7	binding	binding	NN
cord-269011-230p8rsf	588	8	has	have	VBZ
cord-269011-230p8rsf	588	9	been	be	VBN
cord-269011-230p8rsf	588	10	mapped	map	VBN
cord-269011-230p8rsf	588	11	to	to	IN
cord-269011-230p8rsf	588	12	a	a	DT
cord-269011-230p8rsf	588	13	large	large	JJ
cord-269011-230p8rsf	588	14	central	central	JJ
cord-269011-230p8rsf	588	15	domain	domain	NN
cord-269011-230p8rsf	588	16	of	of	IN
cord-269011-230p8rsf	588	17	the	the	DT
cord-269011-230p8rsf	588	18	MHV	MHV	NNP
cord-269011-230p8rsf	588	19	N	N	NNP
cord-269011-230p8rsf	588	20	molecule	molecule	NN
cord-269011-230p8rsf	588	21	(	(	-LRB-
cord-269011-230p8rsf	588	22	Fig	Fig	NNP
cord-269011-230p8rsf	588	23	.	.	.
cord-269011-230p8rsf	588	24	6	6	CD
cord-269011-230p8rsf	588	25	)	)	-RRB-
cord-269011-230p8rsf	589	1	(	(	-LRB-
cord-269011-230p8rsf	589	2	Masters	master	NNS
cord-269011-230p8rsf	589	3	,	,	,
cord-269011-230p8rsf	589	4	1992	1992	CD
cord-269011-230p8rsf	589	5	)	)	-RRB-
cord-269011-230p8rsf	589	6	.	.	.
cord-269011-230p8rsf	590	1	Also	also	RB
cord-269011-230p8rsf	590	2	,	,	,
cord-269011-230p8rsf	590	3	the	the	DT
cord-269011-230p8rsf	590	4	leader	leader	NN
cord-269011-230p8rsf	590	5	-	-	HYPH
cord-269011-230p8rsf	590	6	binding	bind	VBG
cord-269011-230p8rsf	590	7	property	property	NN
cord-269011-230p8rsf	590	8	was	be	VBD
cord-269011-230p8rsf	590	9	assigned	assign	VBN
cord-269011-230p8rsf	590	10	to	to	IN
cord-269011-230p8rsf	590	11	this	this	DT
cord-269011-230p8rsf	590	12	domain	domain	NN
cord-269011-230p8rsf	590	13	;	;	:
cord-269011-230p8rsf	590	14	this	this	DT
cord-269011-230p8rsf	590	15	activity	activity	NN
cord-269011-230p8rsf	590	16	was	be	VBD
cord-269011-230p8rsf	590	17	initially	initially	RB
cord-269011-230p8rsf	590	18	mapped	map	VBN
cord-269011-230p8rsf	590	19	to	to	IN
cord-269011-230p8rsf	590	20	the	the	DT
cord-269011-230p8rsf	590	21	area	area	NN
cord-269011-230p8rsf	590	22	containing	contain	VBG
cord-269011-230p8rsf	590	23	the	the	DT
cord-269011-230p8rsf	590	24	two	two	CD
cord-269011-230p8rsf	590	25	highly	highly	RB
cord-269011-230p8rsf	590	26	basic	basic	JJ
cord-269011-230p8rsf	590	27	regions	region	NNS
cord-269011-230p8rsf	590	28	(	(	-LRB-
cord-269011-230p8rsf	590	29	Nelson	Nelson	NNP
cord-269011-230p8rsf	590	30	and	and	CC
cord-269011-230p8rsf	590	31	Stohlman	Stohlman	NNP
cord-269011-230p8rsf	590	32	,	,	,
cord-269011-230p8rsf	590	33	1993	1993	CD
cord-269011-230p8rsf	590	34	)	)	-RRB-
cord-269011-230p8rsf	590	35	,	,	,
cord-269011-230p8rsf	590	36	but	but	CC
cord-269011-230p8rsf	590	37	was	be	VBD
cord-269011-230p8rsf	590	38	later	later	RB
cord-269011-230p8rsf	590	39	narrowed	narrow	VBN
cord-269011-230p8rsf	590	40	to	to	IN
cord-269011-230p8rsf	590	41	a	a	DT
cord-269011-230p8rsf	590	42	55-residue	55-residue	CD
cord-269011-230p8rsf	590	43	segment	segment	NN
cord-269011-230p8rsf	590	44	containing	contain	VBG
cord-269011-230p8rsf	590	45	the	the	DT
cord-269011-230p8rsf	590	46	serine/	serine/	CD
cord-269011-230p8rsf	590	47	arginine	arginine	NN
cord-269011-230p8rsf	590	48	-	-	HYPH
cord-269011-230p8rsf	590	49	rich	rich	JJ
cord-269011-230p8rsf	590	50	basic	basic	JJ
cord-269011-230p8rsf	590	51	region	region	NN
cord-269011-230p8rsf	590	52	(	(	-LRB-
cord-269011-230p8rsf	590	53	Nelson	Nelson	NNP
cord-269011-230p8rsf	590	54	et	et	NNP
cord-269011-230p8rsf	590	55	al	al	NNP
cord-269011-230p8rsf	590	56	.	.	NNP
cord-269011-230p8rsf	590	57	,	,	,
cord-269011-230p8rsf	590	58	2000	2000	CD
cord-269011-230p8rsf	590	59	)	)	-RRB-
cord-269011-230p8rsf	590	60	.	.	.
cord-269011-230p8rsf	591	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	591	2	,	,	,
cord-269011-230p8rsf	591	3	this	this	DT
cord-269011-230p8rsf	591	4	particular	particular	JJ
cord-269011-230p8rsf	591	5	region	region	NN
cord-269011-230p8rsf	591	6	could	could	MD
cord-269011-230p8rsf	591	7	not	not	RB
cord-269011-230p8rsf	591	8	be	be	VB
cord-269011-230p8rsf	591	9	interchanged	interchange	VBN
cord-269011-230p8rsf	591	10	with	with	IN
cord-269011-230p8rsf	591	11	its	-PRON-	PRP$
cord-269011-230p8rsf	591	12	BCoV	BCoV	NNP
cord-269011-230p8rsf	591	13	counterpart	counterpart	NN
cord-269011-230p8rsf	591	14	in	in	IN
cord-269011-230p8rsf	591	15	a	a	DT
cord-269011-230p8rsf	591	16	study	study	NN
cord-269011-230p8rsf	591	17	on	on	IN
cord-269011-230p8rsf	591	18	the	the	DT
cord-269011-230p8rsf	591	19	functional	functional	JJ
cord-269011-230p8rsf	591	20	equivalence	equivalence	NN
cord-269011-230p8rsf	591	21	of	of	IN
cord-269011-230p8rsf	591	22	the	the	DT
cord-269011-230p8rsf	591	23	N	n	CD
cord-269011-230p8rsf	591	24	proteins	protein	NNS
cord-269011-230p8rsf	591	25	from	from	IN
cord-269011-230p8rsf	591	26	these	these	DT
cord-269011-230p8rsf	591	27	related	relate	VBN
cord-269011-230p8rsf	591	28	viruses	virus	NNS
cord-269011-230p8rsf	592	1	(	(	-LRB-
cord-269011-230p8rsf	592	2	Peng	Peng	NNP
cord-269011-230p8rsf	592	3	et	et	NNP
cord-269011-230p8rsf	592	4	al	al	NNP
cord-269011-230p8rsf	592	5	.	.	NNP
cord-269011-230p8rsf	592	6	,	,	,
cord-269011-230p8rsf	592	7	1995b	1995b	CD
cord-269011-230p8rsf	592	8	)	)	-RRB-
cord-269011-230p8rsf	592	9	.	.	.
cord-269011-230p8rsf	593	1	Another	another	DT
cord-269011-230p8rsf	593	2	domain	domain	NN
cord-269011-230p8rsf	593	3	in	in	IN
cord-269011-230p8rsf	593	4	the	the	DT
cord-269011-230p8rsf	593	5	MHV	MHV	NNP
cord-269011-230p8rsf	593	6	N	N	NNP
cord-269011-230p8rsf	593	7	protein	protein	NN
cord-269011-230p8rsf	593	8	implicated	implicate	VBN
cord-269011-230p8rsf	593	9	in	in	IN
cord-269011-230p8rsf	593	10	viral	viral	JJ
cord-269011-230p8rsf	593	11	RNA	RNA	NNP
cord-269011-230p8rsf	593	12	binding	binding	NN
cord-269011-230p8rsf	593	13	was	be	VBD
cord-269011-230p8rsf	593	14	mapped	map	VBN
cord-269011-230p8rsf	593	15	to	to	IN
cord-269011-230p8rsf	593	16	an	an	DT
cord-269011-230p8rsf	593	17	area	area	NN
cord-269011-230p8rsf	593	18	that	that	WDT
cord-269011-230p8rsf	593	19	partly	partly	RB
cord-269011-230p8rsf	593	20	overlaps	overlap	VBZ
cord-269011-230p8rsf	593	21	with	with	IN
cord-269011-230p8rsf	593	22	the	the	DT
cord-269011-230p8rsf	593	23	second	second	JJ
cord-269011-230p8rsf	593	24	basic	basic	JJ
cord-269011-230p8rsf	593	25	region	region	NN
cord-269011-230p8rsf	593	26	.	.	.
cord-269011-230p8rsf	594	1	The	the	DT
cord-269011-230p8rsf	594	2	assignment	assignment	NN
cord-269011-230p8rsf	594	3	was	be	VBD
cord-269011-230p8rsf	594	4	based	base	VBN
cord-269011-230p8rsf	594	5	on	on	IN
cord-269011-230p8rsf	594	6	an	an	DT
cord-269011-230p8rsf	594	7	analysis	analysis	NN
cord-269011-230p8rsf	594	8	of	of	IN
cord-269011-230p8rsf	594	9	second	second	JJ
cord-269011-230p8rsf	594	10	-	-	HYPH
cord-269011-230p8rsf	594	11	site	site	NN
cord-269011-230p8rsf	594	12	revertants	revertant	NNS
cord-269011-230p8rsf	594	13	of	of	IN
cord-269011-230p8rsf	594	14	MHV	MHV	NNP
cord-269011-230p8rsf	594	15	mutant	mutant	JJ
cord-269011-230p8rsf	594	16	Alb4	Alb4	NNP
cord-269011-230p8rsf	594	17	,	,	,
cord-269011-230p8rsf	594	18	the	the	DT
cord-269011-230p8rsf	594	19	virions	virion	NNS
cord-269011-230p8rsf	594	20	of	of	IN
cord-269011-230p8rsf	594	21	which	which	WDT
cord-269011-230p8rsf	594	22	are	be	VBP
cord-269011-230p8rsf	594	23	extremely	extremely	RB
cord-269011-230p8rsf	594	24	thermolabile	thermolabile	JJ
cord-269011-230p8rsf	594	25	because	because	IN
cord-269011-230p8rsf	594	26	of	of	IN
cord-269011-230p8rsf	594	27	a	a	DT
cord-269011-230p8rsf	594	28	29-residue	29-residue	CD
cord-269011-230p8rsf	594	29	deletion	deletion	NN
cord-269011-230p8rsf	594	30	located	locate	VBN
cord-269011-230p8rsf	594	31	between	between	IN
cord-269011-230p8rsf	594	32	the	the	DT
cord-269011-230p8rsf	594	33	central	central	JJ
cord-269011-230p8rsf	594	34	and	and	CC
cord-269011-230p8rsf	594	35	carboxy	carboxy	JJ
cord-269011-230p8rsf	594	36	-	-	HYPH
cord-269011-230p8rsf	594	37	terminal	terminal	NN
cord-269011-230p8rsf	594	38	domain	domain	NN
cord-269011-230p8rsf	594	39	of	of	IN
cord-269011-230p8rsf	594	40	the	the	DT
cord-269011-230p8rsf	594	41	N	N	NNP
cord-269011-230p8rsf	594	42	protein	protein	NN
cord-269011-230p8rsf	594	43	(	(	-LRB-
cord-269011-230p8rsf	594	44	Koetzner	Koetzner	NNP
cord-269011-230p8rsf	594	45	et	et	NNP
cord-269011-230p8rsf	594	46	al	al	NNP
cord-269011-230p8rsf	594	47	.	.	NNP
cord-269011-230p8rsf	594	48	,	,	,
cord-269011-230p8rsf	594	49	1992	1992	CD
cord-269011-230p8rsf	594	50	)	)	-RRB-
cord-269011-230p8rsf	594	51	.	.	.
cord-269011-230p8rsf	595	1	The	the	DT
cord-269011-230p8rsf	595	2	reverting	reverting	NN
cord-269011-230p8rsf	595	3	mutations	mutation	NNS
cord-269011-230p8rsf	595	4	correlated	correlate	VBN
cord-269011-230p8rsf	595	5	with	with	IN
cord-269011-230p8rsf	595	6	restoration	restoration	NN
cord-269011-230p8rsf	595	7	of	of	IN
cord-269011-230p8rsf	595	8	the	the	DT
cord-269011-230p8rsf	595	9	disturbed	disturbed	JJ
cord-269011-230p8rsf	595	10	RNA	RNA	NNP
cord-269011-230p8rsf	595	11	-	-	HYPH
cord-269011-230p8rsf	595	12	binding	bind	VBG
cord-269011-230p8rsf	595	13	capacity	capacity	NN
cord-269011-230p8rsf	595	14	of	of	IN
cord-269011-230p8rsf	595	15	the	the	DT
cord-269011-230p8rsf	595	16	MHV	MHV	NNP
cord-269011-230p8rsf	595	17	N	N	NNP
cord-269011-230p8rsf	595	18	protein	protein	NN
cord-269011-230p8rsf	595	19	and	and	CC
cord-269011-230p8rsf	595	20	were	be	VBD
cord-269011-230p8rsf	595	21	found	find	VBN
cord-269011-230p8rsf	595	22	clustered	cluster	VBN
cord-269011-230p8rsf	595	23	close	close	RB
cord-269011-230p8rsf	595	24	to	to	IN
cord-269011-230p8rsf	595	25	the	the	DT
cord-269011-230p8rsf	595	26	basic	basic	JJ
cord-269011-230p8rsf	595	27	region	region	NN
cord-269011-230p8rsf	595	28	some	some	DT
cord-269011-230p8rsf	595	29	80	80	CD
cord-269011-230p8rsf	595	30	residues	residue	NNS
cord-269011-230p8rsf	595	31	on	on	IN
cord-269011-230p8rsf	595	32	the	the	DT
cord-269011-230p8rsf	595	33	amino	amino	NN
cord-269011-230p8rsf	595	34	side	side	NN
cord-269011-230p8rsf	595	35	of	of	IN
cord-269011-230p8rsf	595	36	the	the	DT
cord-269011-230p8rsf	595	37	deletion	deletion	NN
cord-269011-230p8rsf	595	38	(	(	-LRB-
cord-269011-230p8rsf	595	39	Fig	Fig	NNP
cord-269011-230p8rsf	595	40	.	.	.
cord-269011-230p8rsf	595	41	6	6	CD
cord-269011-230p8rsf	595	42	)	)	-RRB-
cord-269011-230p8rsf	596	1	(	(	-LRB-
cord-269011-230p8rsf	596	2	Peng	Peng	NNP
cord-269011-230p8rsf	596	3	et	et	NNP
cord-269011-230p8rsf	596	4	al	al	NNP
cord-269011-230p8rsf	596	5	.	.	NNP
cord-269011-230p8rsf	596	6	,	,	,
cord-269011-230p8rsf	596	7	1995a	1995a	CD
cord-269011-230p8rsf	596	8	)	)	-RRB-
cord-269011-230p8rsf	596	9	.	.	.
cord-269011-230p8rsf	597	1	Although	although	IN
cord-269011-230p8rsf	597	2	all	all	PDT
cord-269011-230p8rsf	597	3	these	these	DT
cord-269011-230p8rsf	597	4	studies	study	NNS
cord-269011-230p8rsf	597	5	consistently	consistently	RB
cord-269011-230p8rsf	597	6	attribute	attribute	VBP
cord-269011-230p8rsf	597	7	a	a	DT
cord-269011-230p8rsf	597	8	major	major	JJ
cord-269011-230p8rsf	597	9	role	role	NN
cord-269011-230p8rsf	597	10	in	in	IN
cord-269011-230p8rsf	597	11	RNA	RNA	NNP
cord-269011-230p8rsf	597	12	binding	bind	VBG
cord-269011-230p8rsf	597	13	to	to	IN
cord-269011-230p8rsf	597	14	the	the	DT
cord-269011-230p8rsf	597	15	central	central	JJ
cord-269011-230p8rsf	597	16	portion	portion	NN
cord-269011-230p8rsf	597	17	of	of	IN
cord-269011-230p8rsf	597	18	the	the	DT
cord-269011-230p8rsf	597	19	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	597	20	N	n	CD
cord-269011-230p8rsf	597	21	protein	protein	NN
cord-269011-230p8rsf	597	22	,	,	,
cord-269011-230p8rsf	597	23	the	the	DT
cord-269011-230p8rsf	597	24	interaction	interaction	NN
cord-269011-230p8rsf	597	25	of	of	IN
cord-269011-230p8rsf	597	26	the	the	DT
cord-269011-230p8rsf	597	27	IBV	IBV	NNP
cord-269011-230p8rsf	597	28	N	N	NNP
cord-269011-230p8rsf	597	29	protein	protein	NN
cord-269011-230p8rsf	597	30	with	with	IN
cord-269011-230p8rsf	597	31	the	the	DT
cord-269011-230p8rsf	597	32	3	3	CD
cord-269011-230p8rsf	597	33	0	0	CD
cord-269011-230p8rsf	597	34	UTR	UTR	NNP
cord-269011-230p8rsf	597	35	of	of	IN
cord-269011-230p8rsf	597	36	IBV	IBV	NNP
cord-269011-230p8rsf	597	37	RNA	RNA	NNP
cord-269011-230p8rsf	597	38	mentioned	mention	VBD
cord-269011-230p8rsf	597	39	previously	previously	RB
cord-269011-230p8rsf	597	40	was	be	VBD
cord-269011-230p8rsf	597	41	mapped	map	VBN
cord-269011-230p8rsf	597	42	to	to	IN
cord-269011-230p8rsf	597	43	the	the	DT
cord-269011-230p8rsf	597	44	amino	amino	NN
cord-269011-230p8rsf	597	45	-	-	,
cord-269011-230p8rsf	597	46	and	and	CC
cord-269011-230p8rsf	597	47	carboxy	carboxy	JJ
cord-269011-230p8rsf	597	48	-	-	HYPH
cord-269011-230p8rsf	597	49	terminal	terminal	NN
cord-269011-230p8rsf	597	50	domains	domain	NNS
cord-269011-230p8rsf	597	51	of	of	IN
cord-269011-230p8rsf	597	52	the	the	DT
cord-269011-230p8rsf	597	53	molecule	molecule	NN
cord-269011-230p8rsf	597	54	(	(	-LRB-
cord-269011-230p8rsf	597	55	Zhou	Zhou	NNP
cord-269011-230p8rsf	597	56	and	and	CC
cord-269011-230p8rsf	597	57	Collisson	Collisson	NNP
cord-269011-230p8rsf	597	58	,	,	,
cord-269011-230p8rsf	597	59	2000	2000	CD
cord-269011-230p8rsf	597	60	)	)	-RRB-
cord-269011-230p8rsf	597	61	.	.	.
cord-269011-230p8rsf	598	1	3	3	LS
cord-269011-230p8rsf	598	2	0	0	CD
cord-269011-230p8rsf	599	1	UTR	UTR	NNP
cord-269011-230p8rsf	599	2	RNA	RNA	NNP
cord-269011-230p8rsf	599	3	-	-	HYPH
cord-269011-230p8rsf	599	4	binding	bind	VBG
cord-269011-230p8rsf	599	5	activity	activity	NN
cord-269011-230p8rsf	599	6	was	be	VBD
cord-269011-230p8rsf	599	7	also	also	RB
cord-269011-230p8rsf	599	8	assigned	assign	VBN
cord-269011-230p8rsf	599	9	to	to	IN
cord-269011-230p8rsf	599	10	the	the	DT
cord-269011-230p8rsf	599	11	amino	amino	NN
cord-269011-230p8rsf	599	12	-	-	HYPH
cord-269011-230p8rsf	599	13	terminal	terminal	NN
cord-269011-230p8rsf	599	14	domain	domain	NN
cord-269011-230p8rsf	599	15	of	of	IN
cord-269011-230p8rsf	599	16	the	the	DT
cord-269011-230p8rsf	599	17	SARS	SARS	NNP
cord-269011-230p8rsf	599	18	-	-	HYPH
cord-269011-230p8rsf	599	19	CoV	CoV	NNP
cord-269011-230p8rsf	599	20	N	n	CD
cord-269011-230p8rsf	599	21	protein	protein	NN
cord-269011-230p8rsf	599	22	on	on	IN
cord-269011-230p8rsf	599	23	the	the	DT
cord-269011-230p8rsf	599	24	basis	basis	NN
cord-269011-230p8rsf	599	25	of	of	IN
cord-269011-230p8rsf	599	26	studies	study	NNS
cord-269011-230p8rsf	599	27	using	use	VBG
cord-269011-230p8rsf	599	28	nuclear	nuclear	JJ
cord-269011-230p8rsf	599	29	magnetic	magnetic	JJ
cord-269011-230p8rsf	599	30	resonance	resonance	NN
cord-269011-230p8rsf	599	31	spectroscopy	spectroscopy	NN
cord-269011-230p8rsf	599	32	(	(	-LRB-
cord-269011-230p8rsf	599	33	Huang	Huang	NNP
cord-269011-230p8rsf	599	34	et	et	NNP
cord-269011-230p8rsf	599	35	al	al	NNP
cord-269011-230p8rsf	599	36	.	.	NNP
cord-269011-230p8rsf	599	37	,	,	,
cord-269011-230p8rsf	599	38	2004	2004	CD
cord-269011-230p8rsf	599	39	)	)	-RRB-
cord-269011-230p8rsf	599	40	.	.	.
cord-269011-230p8rsf	600	1	It	-PRON-	PRP
cord-269011-230p8rsf	600	2	is	be	VBZ
cord-269011-230p8rsf	600	3	obvious	obvious	JJ
cord-269011-230p8rsf	600	4	that	that	IN
cord-269011-230p8rsf	600	5	the	the	DT
cord-269011-230p8rsf	600	6	wrapping	wrapping	NN
cord-269011-230p8rsf	600	7	of	of	IN
cord-269011-230p8rsf	600	8	the	the	DT
cord-269011-230p8rsf	600	9	30-kb	30-kb	CD
cord-269011-230p8rsf	600	10	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	600	11	genome	genome	NN
cord-269011-230p8rsf	600	12	into	into	IN
cord-269011-230p8rsf	600	13	the	the	DT
cord-269011-230p8rsf	600	14	compact	compact	JJ
cord-269011-230p8rsf	600	15	helical	helical	JJ
cord-269011-230p8rsf	600	16	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	600	17	is	be	VBZ
cord-269011-230p8rsf	600	18	largely	largely	RB
cord-269011-230p8rsf	600	19	driven	drive	VBN
cord-269011-230p8rsf	600	20	by	by	IN
cord-269011-230p8rsf	600	21	N	n	CD
cord-269011-230p8rsf	600	22	protein	protein	NN
cord-269011-230p8rsf	600	23	interactions	interaction	NNS
cord-269011-230p8rsf	600	24	.	.	.
cord-269011-230p8rsf	601	1	As	as	IN
cord-269011-230p8rsf	601	2	there	there	EX
cord-269011-230p8rsf	601	3	are	be	VBP
cord-269011-230p8rsf	601	4	no	no	DT
cord-269011-230p8rsf	601	5	indications	indication	NNS
cord-269011-230p8rsf	601	6	for	for	IN
cord-269011-230p8rsf	601	7	packaging	packaging	NN
cord-269011-230p8rsf	601	8	of	of	IN
cord-269011-230p8rsf	601	9	the	the	DT
cord-269011-230p8rsf	601	10	RNA	RNA	NNP
cord-269011-230p8rsf	601	11	into	into	IN
cord-269011-230p8rsf	601	12	a	a	DT
cord-269011-230p8rsf	601	13	preformed	preformed	JJ
cord-269011-230p8rsf	601	14	capsid	capsid	NN
cord-269011-230p8rsf	601	15	,	,	,
cord-269011-230p8rsf	601	16	these	these	DT
cord-269011-230p8rsf	601	17	interactions	interaction	NNS
cord-269011-230p8rsf	601	18	can	can	MD
cord-269011-230p8rsf	601	19	be	be	VB
cord-269011-230p8rsf	601	20	described	describe	VBN
cord-269011-230p8rsf	601	21	by	by	IN
cord-269011-230p8rsf	601	22	the	the	DT
cord-269011-230p8rsf	601	23	following	following	JJ
cord-269011-230p8rsf	601	24	model	model	NN
cord-269011-230p8rsf	601	25	.	.	.
cord-269011-230p8rsf	602	1	Packaging	packaging	NN
cord-269011-230p8rsf	602	2	is	be	VBZ
cord-269011-230p8rsf	602	3	initiated	initiate	VBN
cord-269011-230p8rsf	602	4	by	by	IN
cord-269011-230p8rsf	602	5	binding	bind	VBG
cord-269011-230p8rsf	602	6	of	of	IN
cord-269011-230p8rsf	602	7	the	the	DT
cord-269011-230p8rsf	602	8	N	N	NNP
cord-269011-230p8rsf	602	9	protein	protein	NN
cord-269011-230p8rsf	602	10	,	,	,
cord-269011-230p8rsf	602	11	either	either	CC
cord-269011-230p8rsf	602	12	as	as	IN
cord-269011-230p8rsf	602	13	a	a	DT
cord-269011-230p8rsf	602	14	monomer	monomer	NN
cord-269011-230p8rsf	602	15	or	or	CC
cord-269011-230p8rsf	602	16	in	in	IN
cord-269011-230p8rsf	602	17	a	a	DT
cord-269011-230p8rsf	602	18	multimeric	multimeric	JJ
cord-269011-230p8rsf	602	19	form	form	NN
cord-269011-230p8rsf	602	20	,	,	,
cord-269011-230p8rsf	602	21	to	to	IN
cord-269011-230p8rsf	602	22	the	the	DT
cord-269011-230p8rsf	602	23	RNA	RNA	NNP
cord-269011-230p8rsf	602	24	.	.	.
cord-269011-230p8rsf	603	1	By	by	IN
cord-269011-230p8rsf	603	2	analogy	analogy	NN
cord-269011-230p8rsf	603	3	to	to	IN
cord-269011-230p8rsf	603	4	other	other	JJ
cord-269011-230p8rsf	603	5	RNA	RNA	NNP
cord-269011-230p8rsf	603	6	viruses	virus	NNS
cord-269011-230p8rsf	603	7	,	,	,
cord-269011-230p8rsf	603	8	this	this	DT
cord-269011-230p8rsf	603	9	sequence	sequence	NN
cord-269011-230p8rsf	603	10	-	-	HYPH
cord-269011-230p8rsf	603	11	specific	specific	JJ
cord-269011-230p8rsf	603	12	interaction	interaction	NN
cord-269011-230p8rsf	603	13	may	may	MD
cord-269011-230p8rsf	603	14	induce	induce	VB
cord-269011-230p8rsf	603	15	a	a	DT
cord-269011-230p8rsf	603	16	conformational	conformational	JJ
cord-269011-230p8rsf	603	17	change	change	NN
cord-269011-230p8rsf	603	18	in	in	IN
cord-269011-230p8rsf	603	19	the	the	DT
cord-269011-230p8rsf	603	20	N	N	NNP
cord-269011-230p8rsf	603	21	protein	protein	NN
cord-269011-230p8rsf	603	22	,	,	,
cord-269011-230p8rsf	603	23	thereby	thereby	RB
cord-269011-230p8rsf	603	24	creating	create	VBG
cord-269011-230p8rsf	603	25	a	a	DT
cord-269011-230p8rsf	603	26	nucleation	nucleation	NN
cord-269011-230p8rsf	603	27	site	site	NN
cord-269011-230p8rsf	603	28	for	for	IN
cord-269011-230p8rsf	603	29	the	the	DT
cord-269011-230p8rsf	603	30	cooperative	cooperative	JJ
cord-269011-230p8rsf	603	31	stacking	stacking	NN
cord-269011-230p8rsf	603	32	of	of	IN
cord-269011-230p8rsf	603	33	N	n	CD
cord-269011-230p8rsf	603	34	protein	protein	NN
cord-269011-230p8rsf	603	35	units	unit	NNS
cord-269011-230p8rsf	603	36	along	along	IN
cord-269011-230p8rsf	603	37	the	the	DT
cord-269011-230p8rsf	603	38	entire	entire	JJ
cord-269011-230p8rsf	603	39	length	length	NN
cord-269011-230p8rsf	603	40	of	of	IN
cord-269011-230p8rsf	603	41	the	the	DT
cord-269011-230p8rsf	603	42	RNA	RNA	NNP
cord-269011-230p8rsf	603	43	,	,	,
cord-269011-230p8rsf	603	44	now	now	RB
cord-269011-230p8rsf	603	45	in	in	IN
cord-269011-230p8rsf	603	46	a	a	DT
cord-269011-230p8rsf	603	47	non	non	JJ
cord-269011-230p8rsf	603	48	-	-	JJ
cord-269011-230p8rsf	603	49	sequence	sequence	JJ
cord-269011-230p8rsf	603	50	-	-	HYPH
cord-269011-230p8rsf	603	51	specific	specific	JJ
cord-269011-230p8rsf	603	52	way	way	NN
cord-269011-230p8rsf	603	53	.	.	.
cord-269011-230p8rsf	604	1	These	these	DT
cord-269011-230p8rsf	604	2	N	n	CD
cord-269011-230p8rsf	604	3	units	unit	NNS
cord-269011-230p8rsf	604	4	can	can	MD
cord-269011-230p8rsf	604	5	again	again	RB
cord-269011-230p8rsf	604	6	be	be	VB
cord-269011-230p8rsf	604	7	monomeric	monomeric	JJ
cord-269011-230p8rsf	604	8	or	or	CC
cord-269011-230p8rsf	604	9	consist	consist	JJ
cord-269011-230p8rsf	604	10	of	of	IN
cord-269011-230p8rsf	604	11	defined	define	VBN
cord-269011-230p8rsf	604	12	multimers	multimer	NNS
cord-269011-230p8rsf	604	13	.	.	.
cord-269011-230p8rsf	605	1	Finally	finally	RB
cord-269011-230p8rsf	605	2	,	,	,
cord-269011-230p8rsf	605	3	helix	helix	NN
cord-269011-230p8rsf	605	4	formation	formation	NN
cord-269011-230p8rsf	605	5	is	be	VBZ
cord-269011-230p8rsf	605	6	driven	drive	VBN
cord-269011-230p8rsf	605	7	by	by	IN
cord-269011-230p8rsf	605	8	interactions	interaction	NNS
cord-269011-230p8rsf	605	9	between	between	IN
cord-269011-230p8rsf	605	10	N	n	CD
cord-269011-230p8rsf	605	11	molecules	molecule	NNS
cord-269011-230p8rsf	605	12	separated	separate	VBD
cord-269011-230p8rsf	605	13	along	along	IN
cord-269011-230p8rsf	605	14	the	the	DT
cord-269011-230p8rsf	605	15	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	605	16	chain	chain	NN
cord-269011-230p8rsf	605	17	but	but	CC
cord-269011-230p8rsf	605	18	that	that	DT
cord-269011-230p8rsf	605	19	become	become	VBP
cord-269011-230p8rsf	605	20	adjacent	adjacent	JJ
cord-269011-230p8rsf	605	21	in	in	IN
cord-269011-230p8rsf	605	22	neighboring	neighboring	NN
cord-269011-230p8rsf	605	23	helices	helix	NNS
cord-269011-230p8rsf	605	24	.	.	.
cord-269011-230p8rsf	606	1	This	this	DT
cord-269011-230p8rsf	606	2	model	model	NN
cord-269011-230p8rsf	606	3	predicts	predict	VBZ
cord-269011-230p8rsf	606	4	multiple	multiple	JJ
cord-269011-230p8rsf	606	5	nonequivalent	nonequivalent	JJ
cord-269011-230p8rsf	606	6	interactions	interaction	NNS
cord-269011-230p8rsf	606	7	between	between	IN
cord-269011-230p8rsf	606	8	N	n	CD
cord-269011-230p8rsf	606	9	molecules	molecule	NNS
cord-269011-230p8rsf	606	10	.	.	.
cord-269011-230p8rsf	607	1	N	N	NNP
cord-269011-230p8rsf	607	2	-	-	HYPH
cord-269011-230p8rsf	607	3	N	n	CD
cord-269011-230p8rsf	607	4	interactions	interaction	NNS
cord-269011-230p8rsf	607	5	have	have	VBP
cord-269011-230p8rsf	607	6	been	be	VBN
cord-269011-230p8rsf	607	7	experimentally	experimentally	RB
cord-269011-230p8rsf	607	8	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	607	9	for	for	IN
cord-269011-230p8rsf	607	10	MHV	MHV	NNP
cord-269011-230p8rsf	607	11	,	,	,
cord-269011-230p8rsf	607	12	BCoV	BCoV	NNP
cord-269011-230p8rsf	607	13	,	,	,
cord-269011-230p8rsf	607	14	and	and	CC
cord-269011-230p8rsf	607	15	HCoV	HCoV	NNP
cord-269011-230p8rsf	607	16	-	-	HYPH
cord-269011-230p8rsf	607	17	OC43	OC43	NNP
cord-269011-230p8rsf	607	18	.	.	.
cord-269011-230p8rsf	608	1	High	high	JJ
cord-269011-230p8rsf	608	2	molecular	molecular	JJ
cord-269011-230p8rsf	608	3	weight	weight	NN
cord-269011-230p8rsf	608	4	species	specie	NNS
cord-269011-230p8rsf	608	5	of	of	IN
cord-269011-230p8rsf	608	6	the	the	DT
cord-269011-230p8rsf	608	7	N	N	NNP
cord-269011-230p8rsf	608	8	protein	protein	NN
cord-269011-230p8rsf	608	9	,	,	,
cord-269011-230p8rsf	608	10	possibly	possibly	RB
cord-269011-230p8rsf	608	11	trimers	trimers	NNP
cord-269011-230p8rsf	608	12	,	,	,
cord-269011-230p8rsf	608	13	were	be	VBD
cord-269011-230p8rsf	608	14	detected	detect	VBN
cord-269011-230p8rsf	608	15	by	by	IN
cord-269011-230p8rsf	608	16	sodium	sodium	NN
cord-269011-230p8rsf	608	17	dodecyl	dodecyl	NNP
cord-269011-230p8rsf	608	18	sulfatepolyacrylamide	sulfatepolyacrylamide	NNP
cord-269011-230p8rsf	608	19	gel	gel	NN
cord-269011-230p8rsf	608	20	electrophoresis	electrophoresis	NN
cord-269011-230p8rsf	608	21	(	(	-LRB-
cord-269011-230p8rsf	608	22	SDS	SDS	NNP
cord-269011-230p8rsf	608	23	-	-	HYPH
cord-269011-230p8rsf	608	24	PAGE	PAGE	NNP
cord-269011-230p8rsf	608	25	)	)	-RRB-
cord-269011-230p8rsf	608	26	of	of	IN
cord-269011-230p8rsf	608	27	virion	virion	NN
cord-269011-230p8rsf	608	28	preparations	preparation	NNS
cord-269011-230p8rsf	608	29	under	under	IN
cord-269011-230p8rsf	608	30	nonreducing	nonreducing	NN
cord-269011-230p8rsf	608	31	(	(	-LRB-
cord-269011-230p8rsf	608	32	but	but	CC
cord-269011-230p8rsf	608	33	not	not	RB
cord-269011-230p8rsf	608	34	under	under	IN
cord-269011-230p8rsf	608	35	reducing	reduce	VBG
cord-269011-230p8rsf	608	36	)	)	-RRB-
cord-269011-230p8rsf	608	37	conditions	condition	NNS
cord-269011-230p8rsf	608	38	,	,	,
cord-269011-230p8rsf	608	39	which	which	WDT
cord-269011-230p8rsf	608	40	is	be	VBZ
cord-269011-230p8rsf	608	41	indicative	indicative	JJ
cord-269011-230p8rsf	608	42	of	of	IN
cord-269011-230p8rsf	608	43	intermolecular	intermolecular	JJ
cord-269011-230p8rsf	608	44	disulfide	disulfide	JJ
cord-269011-230p8rsf	608	45	bonds	bond	NNS
cord-269011-230p8rsf	608	46	between	between	IN
cord-269011-230p8rsf	608	47	the	the	DT
cord-269011-230p8rsf	608	48	N	n	CD
cord-269011-230p8rsf	608	49	subunits	subunit	NNS
cord-269011-230p8rsf	608	50	(	(	-LRB-
cord-269011-230p8rsf	608	51	Hogue	Hogue	NNP
cord-269011-230p8rsf	608	52	et	et	NNP
cord-269011-230p8rsf	608	53	al	al	NNP
cord-269011-230p8rsf	608	54	.	.	NNP
cord-269011-230p8rsf	608	55	,	,	,
cord-269011-230p8rsf	608	56	1984	1984	CD
cord-269011-230p8rsf	608	57	;	;	:
cord-269011-230p8rsf	608	58	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	608	59	et	et	NNP
cord-269011-230p8rsf	608	60	al	al	NNP
cord-269011-230p8rsf	608	61	.	.	NNP
cord-269011-230p8rsf	608	62	,	,	,
cord-269011-230p8rsf	608	63	2003b	2003b	CD
cord-269011-230p8rsf	608	64	;	;	:
cord-269011-230p8rsf	608	65	Robbins	Robbins	NNP
cord-269011-230p8rsf	608	66	et	et	NNP
cord-269011-230p8rsf	608	67	al	al	NNP
cord-269011-230p8rsf	608	68	.	.	NNP
cord-269011-230p8rsf	608	69	,	,	,
cord-269011-230p8rsf	608	70	1986	1986	CD
cord-269011-230p8rsf	608	71	)	)	-RRB-
cord-269011-230p8rsf	608	72	.	.	.
cord-269011-230p8rsf	609	1	These	these	DT
cord-269011-230p8rsf	609	2	complexes	complex	NNS
cord-269011-230p8rsf	609	3	are	be	VBP
cord-269011-230p8rsf	609	4	likely	likely	JJ
cord-269011-230p8rsf	609	5	to	to	TO
cord-269011-230p8rsf	609	6	be	be	VB
cord-269011-230p8rsf	609	7	additionally	additionally	RB
cord-269011-230p8rsf	609	8	stabilized	stabilize	VBN
cord-269011-230p8rsf	609	9	by	by	IN
cord-269011-230p8rsf	609	10	noncovalent	noncovalent	JJ
cord-269011-230p8rsf	609	11	interactions	interaction	NNS
cord-269011-230p8rsf	609	12	as	as	IN
cord-269011-230p8rsf	609	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	609	14	N	n	CD
cord-269011-230p8rsf	609	15	protein	protein	NN
cord-269011-230p8rsf	609	16	cysteines	cysteine	NNS
cord-269011-230p8rsf	609	17	are	be	VBP
cord-269011-230p8rsf	609	18	not	not	RB
cord-269011-230p8rsf	609	19	well	well	RB
cord-269011-230p8rsf	609	20	conserved	conserve	VBN
cord-269011-230p8rsf	609	21	,	,	,
cord-269011-230p8rsf	609	22	the	the	DT
cord-269011-230p8rsf	609	23	SARS	SARS	NNP
cord-269011-230p8rsf	609	24	-	-	HYPH
cord-269011-230p8rsf	609	25	CoV	CoV	NNP
cord-269011-230p8rsf	609	26	N	n	CD
cord-269011-230p8rsf	609	27	protein	protein	NN
cord-269011-230p8rsf	609	28	even	even	RB
cord-269011-230p8rsf	609	29	lacking	lack	VBG
cord-269011-230p8rsf	609	30	any	any	DT
cord-269011-230p8rsf	609	31	cysteine	cysteine	NN
cord-269011-230p8rsf	609	32	residues	residue	NNS
cord-269011-230p8rsf	609	33	.	.	.
cord-269011-230p8rsf	610	1	Both	both	DT
cord-269011-230p8rsf	610	2	monomeric	monomeric	JJ
cord-269011-230p8rsf	610	3	and	and	CC
cord-269011-230p8rsf	610	4	oligomeric	oligomeric	JJ
cord-269011-230p8rsf	611	1	N	n	CD
cord-269011-230p8rsf	611	2	species	specie	NNS
cord-269011-230p8rsf	611	3	were	be	VBD
cord-269011-230p8rsf	611	4	able	able	JJ
cord-269011-230p8rsf	611	5	to	to	TO
cord-269011-230p8rsf	611	6	bind	bind	VB
cord-269011-230p8rsf	611	7	RNA	RNA	NNP
cord-269011-230p8rsf	611	8	(	(	-LRB-
cord-269011-230p8rsf	611	9	Robbins	Robbins	NNP
cord-269011-230p8rsf	611	10	et	et	NNP
cord-269011-230p8rsf	611	11	al	al	NNP
cord-269011-230p8rsf	611	12	.	.	NNP
cord-269011-230p8rsf	611	13	,	,	,
cord-269011-230p8rsf	611	14	1986	1986	CD
cord-269011-230p8rsf	611	15	)	)	-RRB-
cord-269011-230p8rsf	611	16	.	.	.
cord-269011-230p8rsf	612	1	Multimeric	multimeric	JJ
cord-269011-230p8rsf	612	2	forms	form	NNS
cord-269011-230p8rsf	612	3	of	of	IN
cord-269011-230p8rsf	612	4	the	the	DT
cord-269011-230p8rsf	612	5	N	N	NNP
cord-269011-230p8rsf	612	6	protein	protein	NN
cord-269011-230p8rsf	612	7	were	be	VBD
cord-269011-230p8rsf	612	8	also	also	RB
cord-269011-230p8rsf	612	9	found	find	VBN
cord-269011-230p8rsf	612	10	in	in	IN
cord-269011-230p8rsf	612	11	association	association	NN
cord-269011-230p8rsf	612	12	with	with	IN
cord-269011-230p8rsf	612	13	intracellular	intracellular	JJ
cord-269011-230p8rsf	612	14	genomic	genomic	JJ
cord-269011-230p8rsf	612	15	RNA	rna	NN
cord-269011-230p8rsf	612	16	in	in	IN
cord-269011-230p8rsf	612	17	MHV	MHV	NNP
cord-269011-230p8rsf	612	18	-	-	HYPH
cord-269011-230p8rsf	612	19	infected	infect	VBN
cord-269011-230p8rsf	612	20	cells	cell	NNS
cord-269011-230p8rsf	612	21	as	as	IN
cord-269011-230p8rsf	612	22	shown	show	VBN
cord-269011-230p8rsf	612	23	after	after	IN
cord-269011-230p8rsf	612	24	the	the	DT
cord-269011-230p8rsf	612	25	selective	selective	JJ
cord-269011-230p8rsf	612	26	isolation	isolation	NN
cord-269011-230p8rsf	612	27	of	of	IN
cord-269011-230p8rsf	612	28	this	this	DT
cord-269011-230p8rsf	612	29	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	612	30	through	through	IN
cord-269011-230p8rsf	612	31	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	612	32	with	with	IN
cord-269011-230p8rsf	612	33	the	the	DT
cord-269011-230p8rsf	612	34	M	M	NNP
cord-269011-230p8rsf	612	35	protein	protein	NN
cord-269011-230p8rsf	612	36	(	(	-LRB-
cord-269011-230p8rsf	612	37	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	612	38	et	et	NNP
cord-269011-230p8rsf	612	39	al	al	NNP
cord-269011-230p8rsf	612	40	.	.	NNP
cord-269011-230p8rsf	612	41	,	,	,
cord-269011-230p8rsf	612	42	2003b	2003b	CD
cord-269011-230p8rsf	612	43	)	)	-RRB-
cord-269011-230p8rsf	612	44	.	.	.
cord-269011-230p8rsf	613	1	High	high	JJ
cord-269011-230p8rsf	613	2	molecular	molecular	JJ
cord-269011-230p8rsf	613	3	weight	weight	NN
cord-269011-230p8rsf	613	4	forms	form	NNS
cord-269011-230p8rsf	613	5	of	of	IN
cord-269011-230p8rsf	613	6	the	the	DT
cord-269011-230p8rsf	613	7	N	N	NNP
cord-269011-230p8rsf	613	8	protein	protein	NN
cord-269011-230p8rsf	613	9	corresponding	correspond	VBG
cord-269011-230p8rsf	613	10	to	to	IN
cord-269011-230p8rsf	613	11	dimers	dimer	NNS
cord-269011-230p8rsf	613	12	and	and	CC
cord-269011-230p8rsf	613	13	trimers	trimer	NNS
cord-269011-230p8rsf	613	14	were	be	VBD
cord-269011-230p8rsf	613	15	also	also	RB
cord-269011-230p8rsf	613	16	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	613	17	in	in	IN
cord-269011-230p8rsf	613	18	vitro	vitro	FW
cord-269011-230p8rsf	613	19	after	after	IN
cord-269011-230p8rsf	613	20	ultraviolet	ultraviolet	NN
cord-269011-230p8rsf	613	21	(	(	-LRB-
cord-269011-230p8rsf	613	22	UV	UV	NNP
cord-269011-230p8rsf	613	23	)	)	-RRB-
cord-269011-230p8rsf	613	24	cross	cross	NN
cord-269011-230p8rsf	613	25	-	-	NN
cord-269011-230p8rsf	613	26	linking	linking	NN
cord-269011-230p8rsf	613	27	of	of	IN
cord-269011-230p8rsf	613	28	BCoV	BCoV	NNP
cord-269011-230p8rsf	613	29	N	n	CD
cord-269011-230p8rsf	613	30	protein	protein	NN
cord-269011-230p8rsf	613	31	to	to	IN
cord-269011-230p8rsf	613	32	RNAs	rna	NNS
cord-269011-230p8rsf	613	33	.	.	.
cord-269011-230p8rsf	614	1	Few	few	JJ
cord-269011-230p8rsf	614	2	studies	study	NNS
cord-269011-230p8rsf	614	3	have	have	VBP
cord-269011-230p8rsf	614	4	addressed	address	VBN
cord-269011-230p8rsf	614	5	the	the	DT
cord-269011-230p8rsf	614	6	identification	identification	NN
cord-269011-230p8rsf	614	7	of	of	IN
cord-269011-230p8rsf	614	8	the	the	DT
cord-269011-230p8rsf	614	9	N	N	NNP
cord-269011-230p8rsf	614	10	-	-	HYPH
cord-269011-230p8rsf	614	11	N	n	CD
cord-269011-230p8rsf	614	12	interaction	interaction	NN
cord-269011-230p8rsf	614	13	domains	domain	NNS
cord-269011-230p8rsf	614	14	.	.	.
cord-269011-230p8rsf	615	1	The	the	DT
cord-269011-230p8rsf	615	2	results	result	NNS
cord-269011-230p8rsf	615	3	so	so	RB
cord-269011-230p8rsf	615	4	far	far	RB
cord-269011-230p8rsf	615	5	are	be	VBP
cord-269011-230p8rsf	615	6	inconsistent	inconsistent	JJ
cord-269011-230p8rsf	615	7	(	(	-LRB-
cord-269011-230p8rsf	615	8	Fig	Fig	NNP
cord-269011-230p8rsf	615	9	.	.	.
cord-269011-230p8rsf	615	10	6	6	CD
cord-269011-230p8rsf	615	11	)	)	-RRB-
cord-269011-230p8rsf	615	12	,	,	,
cord-269011-230p8rsf	615	13	but	but	CC
cord-269011-230p8rsf	615	14	this	this	DT
cord-269011-230p8rsf	615	15	might	may	MD
cord-269011-230p8rsf	615	16	as	as	RB
cord-269011-230p8rsf	615	17	well	well	RB
cord-269011-230p8rsf	615	18	reflect	reflect	VB
cord-269011-230p8rsf	615	19	the	the	DT
cord-269011-230p8rsf	615	20	predicted	predict	VBN
cord-269011-230p8rsf	615	21	occurrence	occurrence	NN
cord-269011-230p8rsf	615	22	of	of	IN
cord-269011-230p8rsf	615	23	nonequivalent	nonequivalent	JJ
cord-269011-230p8rsf	615	24	interactions	interaction	NNS
cord-269011-230p8rsf	615	25	.	.	.
cord-269011-230p8rsf	616	1	Interaction	interaction	NN
cord-269011-230p8rsf	616	2	sites	site	NNS
cord-269011-230p8rsf	616	3	were	be	VBD
cord-269011-230p8rsf	616	4	mapped	map	VBN
cord-269011-230p8rsf	616	5	to	to	IN
cord-269011-230p8rsf	616	6	the	the	DT
cord-269011-230p8rsf	616	7	amino	amino	NN
cord-269011-230p8rsf	616	8	-	-	HYPH
cord-269011-230p8rsf	616	9	terminal	terminal	NN
cord-269011-230p8rsf	616	10	part	part	NN
cord-269011-230p8rsf	616	11	of	of	IN
cord-269011-230p8rsf	616	12	the	the	DT
cord-269011-230p8rsf	616	13	MHV	MHV	NNP
cord-269011-230p8rsf	616	14	N	N	NNP
cord-269011-230p8rsf	616	15	protein	protein	NN
cord-269011-230p8rsf	616	16	(	(	-LRB-
cord-269011-230p8rsf	616	17	Wang	Wang	NNP
cord-269011-230p8rsf	616	18	and	and	CC
cord-269011-230p8rsf	616	19	Zhang	Zhang	NNP
cord-269011-230p8rsf	616	20	,	,	,
cord-269011-230p8rsf	616	21	1999	1999	CD
cord-269011-230p8rsf	616	22	)	)	-RRB-
cord-269011-230p8rsf	616	23	.	.	.
cord-269011-230p8rsf	617	1	Using	use	VBG
cord-269011-230p8rsf	617	2	an	an	DT
cord-269011-230p8rsf	617	3	in	in	FW
cord-269011-230p8rsf	617	4	vitro	vitro	FW
cord-269011-230p8rsf	617	5	binding	bind	VBG
cord-269011-230p8rsf	617	6	assay	assay	NN
cord-269011-230p8rsf	617	7	in	in	IN
cord-269011-230p8rsf	617	8	which	which	WDT
cord-269011-230p8rsf	617	9	the	the	DT
cord-269011-230p8rsf	617	10	full	full	JJ
cord-269011-230p8rsf	617	11	-	-	HYPH
cord-269011-230p8rsf	617	12	length	length	NN
cord-269011-230p8rsf	617	13	N	n	CD
cord-269011-230p8rsf	617	14	protein	protein	NN
cord-269011-230p8rsf	617	15	was	be	VBD
cord-269011-230p8rsf	617	16	incubated	incubate	VBN
cord-269011-230p8rsf	617	17	with	with	IN
cord-269011-230p8rsf	617	18	bacterially	bacterially	RB
cord-269011-230p8rsf	617	19	expressed	express	VBN
cord-269011-230p8rsf	617	20	fusion	fusion	NN
cord-269011-230p8rsf	617	21	proteins	protein	NNS
cord-269011-230p8rsf	617	22	containing	contain	VBG
cord-269011-230p8rsf	617	23	different	different	JJ
cord-269011-230p8rsf	617	24	segments	segment	NNS
cord-269011-230p8rsf	617	25	of	of	IN
cord-269011-230p8rsf	617	26	the	the	DT
cord-269011-230p8rsf	617	27	N	N	NNP
cord-269011-230p8rsf	617	28	protein	protein	NN
cord-269011-230p8rsf	617	29	,	,	,
cord-269011-230p8rsf	617	30	interaction	interaction	NN
cord-269011-230p8rsf	617	31	was	be	VBD
cord-269011-230p8rsf	617	32	observed	observe	VBN
cord-269011-230p8rsf	617	33	with	with	IN
cord-269011-230p8rsf	617	34	a	a	DT
cord-269011-230p8rsf	617	35	polypeptide	polypeptide	NN
cord-269011-230p8rsf	617	36	derived	derive	VBN
cord-269011-230p8rsf	617	37	from	from	IN
cord-269011-230p8rsf	617	38	the	the	DT
cord-269011-230p8rsf	617	39	amino	amino	NN
cord-269011-230p8rsf	617	40	-	-	HYPH
cord-269011-230p8rsf	617	41	terminal	terminal	NN
cord-269011-230p8rsf	617	42	one	one	CD
cord-269011-230p8rsf	617	43	-	-	HYPH
cord-269011-230p8rsf	617	44	third	third	NN
cord-269011-230p8rsf	617	45	(	(	-LRB-
cord-269011-230p8rsf	617	46	residues	residue	NNS
cord-269011-230p8rsf	617	47	1	1	CD
cord-269011-230p8rsf	617	48	-	-	SYM
cord-269011-230p8rsf	617	49	162	162	CD
cord-269011-230p8rsf	617	50	)	)	-RRB-
cord-269011-230p8rsf	617	51	of	of	IN
cord-269011-230p8rsf	617	52	the	the	DT
cord-269011-230p8rsf	617	53	protein	protein	NN
cord-269011-230p8rsf	617	54	and	and	CC
cord-269011-230p8rsf	617	55	with	with	IN
cord-269011-230p8rsf	617	56	a	a	DT
cord-269011-230p8rsf	617	57	polypeptide	polypeptide	NN
cord-269011-230p8rsf	617	58	representing	represent	VBG
cord-269011-230p8rsf	617	59	the	the	DT
cord-269011-230p8rsf	617	60	central	central	JJ
cord-269011-230p8rsf	617	61	part	part	NN
cord-269011-230p8rsf	617	62	(	(	-LRB-
cord-269011-230p8rsf	617	63	residues	residue	NNS
cord-269011-230p8rsf	617	64	163	163	CD
cord-269011-230p8rsf	617	65	-	-	SYM
cord-269011-230p8rsf	617	66	292	292	CD
cord-269011-230p8rsf	617	67	)	)	-RRB-
cord-269011-230p8rsf	617	68	.	.	.
cord-269011-230p8rsf	618	1	The	the	DT
cord-269011-230p8rsf	618	2	latter	latter	JJ
cord-269011-230p8rsf	618	3	domain	domain	NN
cord-269011-230p8rsf	618	4	contains	contain	VBZ
cord-269011-230p8rsf	618	5	the	the	DT
cord-269011-230p8rsf	618	6	serine	serine	NN
cord-269011-230p8rsf	618	7	/	/	SYM
cord-269011-230p8rsf	618	8	arginine	arginine	NN
cord-269011-230p8rsf	618	9	-	-	HYPH
cord-269011-230p8rsf	618	10	rich	rich	JJ
cord-269011-230p8rsf	618	11	region	region	NN
cord-269011-230p8rsf	618	12	implicated	implicate	VBN
cord-269011-230p8rsf	618	13	in	in	IN
cord-269011-230p8rsf	618	14	the	the	DT
cord-269011-230p8rsf	618	15	binding	binding	NN
cord-269011-230p8rsf	618	16	to	to	IN
cord-269011-230p8rsf	618	17	the	the	DT
cord-269011-230p8rsf	618	18	leader	leader	NN
cord-269011-230p8rsf	618	19	/	/	SYM
cord-269011-230p8rsf	618	20	TRS	trs	NN
cord-269011-230p8rsf	618	21	-	-	HYPH
cord-269011-230p8rsf	618	22	specific	specific	JJ
cord-269011-230p8rsf	618	23	sequences	sequence	NNS
cord-269011-230p8rsf	619	1	(	(	-LRB-
cord-269011-230p8rsf	619	2	Nelson	Nelson	NNP
cord-269011-230p8rsf	619	3	et	et	NNP
cord-269011-230p8rsf	619	4	al	al	NNP
cord-269011-230p8rsf	619	5	.	.	NNP
cord-269011-230p8rsf	619	6	,	,	,
cord-269011-230p8rsf	619	7	2000	2000	CD
cord-269011-230p8rsf	619	8	)	)	-RRB-
cord-269011-230p8rsf	619	9	.	.	.
cord-269011-230p8rsf	620	1	This	this	DT
cord-269011-230p8rsf	620	2	domain	domain	NN
cord-269011-230p8rsf	620	3	could	could	MD
cord-269011-230p8rsf	620	4	not	not	RB
cord-269011-230p8rsf	620	5	be	be	VB
cord-269011-230p8rsf	620	6	replaced	replace	VBN
cord-269011-230p8rsf	620	7	by	by	IN
cord-269011-230p8rsf	620	8	the	the	DT
cord-269011-230p8rsf	620	9	corresponding	corresponding	JJ
cord-269011-230p8rsf	620	10	domain	domain	NN
cord-269011-230p8rsf	620	11	from	from	IN
cord-269011-230p8rsf	620	12	BCoV	BCoV	NNP
cord-269011-230p8rsf	620	13	without	without	IN
cord-269011-230p8rsf	620	14	loss	loss	NN
cord-269011-230p8rsf	620	15	of	of	IN
cord-269011-230p8rsf	620	16	viral	viral	JJ
cord-269011-230p8rsf	620	17	viability	viability	NN
cord-269011-230p8rsf	620	18	,	,	,
cord-269011-230p8rsf	620	19	from	from	IN
cord-269011-230p8rsf	620	20	which	which	WDT
cord-269011-230p8rsf	620	21	the	the	DT
cord-269011-230p8rsf	620	22	authors	author	NNS
cord-269011-230p8rsf	620	23	indeed	indeed	RB
cord-269011-230p8rsf	620	24	inferred	infer	VBD
cord-269011-230p8rsf	620	25	an	an	DT
cord-269011-230p8rsf	620	26	involvement	involvement	NN
cord-269011-230p8rsf	620	27	in	in	IN
cord-269011-230p8rsf	620	28	protein	protein	NN
cord-269011-230p8rsf	620	29	-	-	HYPH
cord-269011-230p8rsf	620	30	protein	protein	NN
cord-269011-230p8rsf	620	31	interactions	interaction	NNS
cord-269011-230p8rsf	620	32	(	(	-LRB-
cord-269011-230p8rsf	620	33	Peng	Peng	NNP
cord-269011-230p8rsf	620	34	et	et	NNP
cord-269011-230p8rsf	620	35	al	al	NNP
cord-269011-230p8rsf	620	36	.	.	NNP
cord-269011-230p8rsf	620	37	,	,	,
cord-269011-230p8rsf	620	38	1995b	1995b	CD
cord-269011-230p8rsf	620	39	)	)	-RRB-
cord-269011-230p8rsf	620	40	.	.	.
cord-269011-230p8rsf	621	1	The	the	DT
cord-269011-230p8rsf	621	2	same	same	JJ
cord-269011-230p8rsf	621	3	domain	domain	NN
cord-269011-230p8rsf	621	4	was	be	VBD
cord-269011-230p8rsf	621	5	also	also	RB
cord-269011-230p8rsf	621	6	shown	show	VBN
cord-269011-230p8rsf	621	7	to	to	TO
cord-269011-230p8rsf	621	8	be	be	VB
cord-269011-230p8rsf	621	9	essential	essential	JJ
cord-269011-230p8rsf	621	10	for	for	IN
cord-269011-230p8rsf	621	11	the	the	DT
cord-269011-230p8rsf	621	12	homotypic	homotypic	NNP
cord-269011-230p8rsf	621	13	association	association	NNP
cord-269011-230p8rsf	621	14	of	of	IN
cord-269011-230p8rsf	621	15	the	the	DT
cord-269011-230p8rsf	621	16	SARS	SARS	NNP
cord-269011-230p8rsf	621	17	-	-	HYPH
cord-269011-230p8rsf	621	18	CoV	CoV	NNP
cord-269011-230p8rsf	621	19	N	n	CD
cord-269011-230p8rsf	621	20	protein	protein	NN
cord-269011-230p8rsf	621	21	.	.	.
cord-269011-230p8rsf	622	1	Using	use	VBG
cord-269011-230p8rsf	622	2	a	a	DT
cord-269011-230p8rsf	622	3	mammalian	mammalian	JJ
cord-269011-230p8rsf	622	4	two	two	CD
cord-269011-230p8rsf	622	5	-	-	HYPH
cord-269011-230p8rsf	622	6	hybrid	hybrid	NN
cord-269011-230p8rsf	622	7	approach	approach	NN
cord-269011-230p8rsf	622	8	,	,	,
cord-269011-230p8rsf	622	9	the	the	DT
cord-269011-230p8rsf	622	10	N	N	NNP
cord-269011-230p8rsf	622	11	-	-	HYPH
cord-269011-230p8rsf	622	12	N	n	CD
cord-269011-230p8rsf	622	13	interaction	interaction	NN
cord-269011-230p8rsf	622	14	appeared	appear	VBD
cord-269011-230p8rsf	622	15	to	to	TO
cord-269011-230p8rsf	622	16	be	be	VB
cord-269011-230p8rsf	622	17	abolished	abolish	VBN
cord-269011-230p8rsf	622	18	completely	completely	RB
cord-269011-230p8rsf	622	19	when	when	WRB
cord-269011-230p8rsf	622	20	the	the	DT
cord-269011-230p8rsf	622	21	serine	serine	NN
cord-269011-230p8rsf	622	22	/	/	SYM
cord-269011-230p8rsf	622	23	arginine	arginine	NN
cord-269011-230p8rsf	622	24	-	-	HYPH
cord-269011-230p8rsf	622	25	rich	rich	JJ
cord-269011-230p8rsf	622	26	region	region	NN
cord-269011-230p8rsf	622	27	had	have	VBD
cord-269011-230p8rsf	622	28	been	be	VBN
cord-269011-230p8rsf	622	29	deleted	delete	VBN
cord-269011-230p8rsf	622	30	.	.	.
cord-269011-230p8rsf	623	1	However	however	RB
cord-269011-230p8rsf	623	2	,	,	,
cord-269011-230p8rsf	623	3	in	in	IN
cord-269011-230p8rsf	623	4	another	another	DT
cord-269011-230p8rsf	623	5	study	study	NN
cord-269011-230p8rsf	623	6	using	use	VBG
cord-269011-230p8rsf	623	7	the	the	DT
cord-269011-230p8rsf	623	8	yeast	yeast	NN
cord-269011-230p8rsf	623	9	two	two	CD
cord-269011-230p8rsf	623	10	-	-	HYPH
cord-269011-230p8rsf	623	11	hybrid	hybrid	NN
cord-269011-230p8rsf	623	12	system	system	NN
cord-269011-230p8rsf	623	13	this	this	DT
cord-269011-230p8rsf	623	14	interaction	interaction	NN
cord-269011-230p8rsf	623	15	was	be	VBD
cord-269011-230p8rsf	623	16	not	not	RB
cord-269011-230p8rsf	623	17	confirmed	confirm	VBN
cord-269011-230p8rsf	623	18	.	.	.
cord-269011-230p8rsf	624	1	A	a	DT
cord-269011-230p8rsf	624	2	polypeptide	polypeptide	NN
cord-269011-230p8rsf	624	3	consisting	consist	VBG
cord-269011-230p8rsf	624	4	of	of	IN
cord-269011-230p8rsf	624	5	the	the	DT
cord-269011-230p8rsf	624	6	amino	amino	NN
cord-269011-230p8rsf	624	7	-	-	HYPH
cord-269011-230p8rsf	624	8	terminal	terminal	NN
cord-269011-230p8rsf	624	9	two	two	CD
cord-269011-230p8rsf	624	10	-	-	HYPH
cord-269011-230p8rsf	624	11	thirds	third	NNS
cord-269011-230p8rsf	624	12	of	of	IN
cord-269011-230p8rsf	624	13	the	the	DT
cord-269011-230p8rsf	624	14	SARS	SARS	NNP
cord-269011-230p8rsf	624	15	-	-	HYPH
cord-269011-230p8rsf	624	16	CoV	CoV	NNP
cord-269011-230p8rsf	624	17	N	n	CD
cord-269011-230p8rsf	624	18	protein	protein	NN
cord-269011-230p8rsf	625	1	,	,	,
cord-269011-230p8rsf	625	2	that	that	DT
cord-269011-230p8rsf	625	3	contains	contain	VBZ
cord-269011-230p8rsf	625	4	the	the	DT
cord-269011-230p8rsf	625	5	serine	serine	NN
cord-269011-230p8rsf	625	6	/	/	SYM
cord-269011-230p8rsf	625	7	arginine	arginine	NN
cord-269011-230p8rsf	625	8	-	-	HYPH
cord-269011-230p8rsf	625	9	rich	rich	JJ
cord-269011-230p8rsf	625	10	region	region	NN
cord-269011-230p8rsf	625	11	,	,	,
cord-269011-230p8rsf	625	12	exhibited	exhibit	VBD
cord-269011-230p8rsf	625	13	no	no	DT
cord-269011-230p8rsf	625	14	association	association	NN
cord-269011-230p8rsf	625	15	with	with	IN
cord-269011-230p8rsf	625	16	the	the	DT
cord-269011-230p8rsf	625	17	full	full	JJ
cord-269011-230p8rsf	625	18	-	-	HYPH
cord-269011-230p8rsf	625	19	length	length	NN
cord-269011-230p8rsf	625	20	protein	protein	NN
cord-269011-230p8rsf	625	21	(	(	-LRB-
cord-269011-230p8rsf	625	22	Surjit	Surjit	NNP
cord-269011-230p8rsf	625	23	et	et	NNP
cord-269011-230p8rsf	625	24	al	al	NNP
cord-269011-230p8rsf	625	25	.	.	NNP
cord-269011-230p8rsf	625	26	,	,	,
cord-269011-230p8rsf	625	27	2004	2004	CD
cord-269011-230p8rsf	625	28	)	)	-RRB-
cord-269011-230p8rsf	625	29	.	.	.
cord-269011-230p8rsf	626	1	Rather	rather	RB
cord-269011-230p8rsf	626	2	,	,	,
cord-269011-230p8rsf	626	3	self	self	NN
cord-269011-230p8rsf	626	4	-	-	HYPH
cord-269011-230p8rsf	626	5	association	association	NN
cord-269011-230p8rsf	626	6	was	be	VBD
cord-269011-230p8rsf	626	7	attributed	attribute	VBN
cord-269011-230p8rsf	626	8	to	to	IN
cord-269011-230p8rsf	626	9	the	the	DT
cord-269011-230p8rsf	626	10	carboxy	carboxy	JJ
cord-269011-230p8rsf	626	11	-	-	HYPH
cord-269011-230p8rsf	626	12	terminal	terminal	NN
cord-269011-230p8rsf	626	13	209	209	CD
cord-269011-230p8rsf	626	14	residues	residue	NNS
cord-269011-230p8rsf	626	15	of	of	IN
cord-269011-230p8rsf	626	16	the	the	DT
cord-269011-230p8rsf	626	17	molecule	molecule	NN
cord-269011-230p8rsf	626	18	,	,	,
cord-269011-230p8rsf	626	19	which	which	WDT
cord-269011-230p8rsf	626	20	lacks	lack	VBZ
cord-269011-230p8rsf	626	21	the	the	DT
cord-269011-230p8rsf	626	22	motif	motif	NN
cord-269011-230p8rsf	626	23	.	.	.
cord-269011-230p8rsf	627	1	Unlike	unlike	IN
cord-269011-230p8rsf	627	2	most	most	JJS
cord-269011-230p8rsf	627	3	other	other	JJ
cord-269011-230p8rsf	627	4	enveloped	envelop	VBN
cord-269011-230p8rsf	627	5	viruses	virus	NNS
cord-269011-230p8rsf	627	6	,	,	,
cord-269011-230p8rsf	627	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	627	8	have	have	VBP
cord-269011-230p8rsf	627	9	the	the	DT
cord-269011-230p8rsf	627	10	remarkable	remarkable	JJ
cord-269011-230p8rsf	627	11	feature	feature	NN
cord-269011-230p8rsf	627	12	of	of	IN
cord-269011-230p8rsf	627	13	being	be	VBG
cord-269011-230p8rsf	627	14	able	able	JJ
cord-269011-230p8rsf	627	15	to	to	TO
cord-269011-230p8rsf	627	16	independently	independently	RB
cord-269011-230p8rsf	627	17	assemble	assemble	VB
cord-269011-230p8rsf	627	18	their	-PRON-	PRP$
cord-269011-230p8rsf	627	19	envelope	envelope	NN
cord-269011-230p8rsf	627	20	.	.	.
cord-269011-230p8rsf	628	1	Indications	indication	NNS
cord-269011-230p8rsf	628	2	for	for	IN
cord-269011-230p8rsf	628	3	this	this	DT
cord-269011-230p8rsf	628	4	were	be	VBD
cord-269011-230p8rsf	628	5	already	already	RB
cord-269011-230p8rsf	628	6	noticed	notice	VBN
cord-269011-230p8rsf	628	7	in	in	IN
cord-269011-230p8rsf	628	8	early	early	JJ
cord-269011-230p8rsf	628	9	electron	electron	NN
cord-269011-230p8rsf	628	10	microscopy	microscopy	NN
cord-269011-230p8rsf	628	11	studies	study	NNS
cord-269011-230p8rsf	628	12	of	of	IN
cord-269011-230p8rsf	628	13	viral	viral	JJ
cord-269011-230p8rsf	628	14	preparations	preparation	NNS
cord-269011-230p8rsf	628	15	and	and	CC
cord-269011-230p8rsf	628	16	infected	infected	JJ
cord-269011-230p8rsf	628	17	cells	cell	NNS
cord-269011-230p8rsf	628	18	showing	show	VBG
cord-269011-230p8rsf	628	19	the	the	DT
cord-269011-230p8rsf	628	20	occurrence	occurrence	NN
cord-269011-230p8rsf	628	21	of	of	IN
cord-269011-230p8rsf	628	22	apparently	apparently	RB
cord-269011-230p8rsf	628	23	"	"	``
cord-269011-230p8rsf	628	24	empty	empty	JJ
cord-269011-230p8rsf	628	25	"	"	''
cord-269011-230p8rsf	628	26	particles	particle	NNS
cord-269011-230p8rsf	628	27	(	(	-LRB-
cord-269011-230p8rsf	628	28	Afzelius	Afzelius	NNP
cord-269011-230p8rsf	628	29	,	,	,
cord-269011-230p8rsf	628	30	1994	1994	CD
cord-269011-230p8rsf	628	31	;	;	:
cord-269011-230p8rsf	628	32	Chasey	Chasey	NNP
cord-269011-230p8rsf	628	33	and	and	CC
cord-269011-230p8rsf	628	34	Alexander	Alexander	NNP
cord-269011-230p8rsf	628	35	,	,	,
cord-269011-230p8rsf	628	36	1976	1976	CD
cord-269011-230p8rsf	628	37	;	;	:
cord-269011-230p8rsf	628	38	Macnaughton	Macnaughton	NNP
cord-269011-230p8rsf	628	39	and	and	CC
cord-269011-230p8rsf	628	40	Davies	Davies	NNP
cord-269011-230p8rsf	628	41	,	,	,
cord-269011-230p8rsf	628	42	1980	1980	CD
cord-269011-230p8rsf	628	43	)	)	-RRB-
cord-269011-230p8rsf	628	44	.	.	.
cord-269011-230p8rsf	629	1	Incomplete	incomplete	JJ
cord-269011-230p8rsf	629	2	virions	virion	NNS
cord-269011-230p8rsf	629	3	with	with	IN
cord-269011-230p8rsf	629	4	the	the	DT
cord-269011-230p8rsf	629	5	typical	typical	JJ
cord-269011-230p8rsf	629	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	629	7	morphology	morphology	NN
cord-269011-230p8rsf	629	8	but	but	CC
cord-269011-230p8rsf	629	9	lacking	lack	VBG
cord-269011-230p8rsf	629	10	the	the	DT
cord-269011-230p8rsf	629	11	N	n	CD
cord-269011-230p8rsf	629	12	protein	protein	NN
cord-269011-230p8rsf	629	13	and	and	CC
cord-269011-230p8rsf	629	14	the	the	DT
cord-269011-230p8rsf	629	15	genome	genome	NN
cord-269011-230p8rsf	629	16	could	could	MD
cord-269011-230p8rsf	629	17	indeed	indeed	RB
cord-269011-230p8rsf	629	18	be	be	VB
cord-269011-230p8rsf	629	19	separated	separate	VBN
cord-269011-230p8rsf	629	20	from	from	IN
cord-269011-230p8rsf	629	21	normal	normal	JJ
cord-269011-230p8rsf	629	22	IBV	IBV	NNP
cord-269011-230p8rsf	629	23	particles	particle	NNS
cord-269011-230p8rsf	629	24	by	by	IN
cord-269011-230p8rsf	629	25	their	-PRON-	PRP$
cord-269011-230p8rsf	629	26	lower	low	JJR
cord-269011-230p8rsf	629	27	density	density	NN
cord-269011-230p8rsf	629	28	in	in	IN
cord-269011-230p8rsf	629	29	sucrose	sucrose	NN
cord-269011-230p8rsf	629	30	gradients	gradient	NNS
cord-269011-230p8rsf	629	31	(	(	-LRB-
cord-269011-230p8rsf	629	32	Macnaughton	Macnaughton	NNP
cord-269011-230p8rsf	629	33	and	and	CC
cord-269011-230p8rsf	629	34	Davies	Davies	NNP
cord-269011-230p8rsf	629	35	,	,	,
cord-269011-230p8rsf	629	36	1980	1980	CD
cord-269011-230p8rsf	629	37	)	)	-RRB-
cord-269011-230p8rsf	629	38	.	.	.
cord-269011-230p8rsf	630	1	The	the	DT
cord-269011-230p8rsf	630	2	definition	definition	NN
cord-269011-230p8rsf	630	3	of	of	IN
cord-269011-230p8rsf	630	4	virus	virus	NN
cord-269011-230p8rsf	630	5	-	-	HYPH
cord-269011-230p8rsf	630	6	like	like	JJ
cord-269011-230p8rsf	630	7	particles	particle	NNS
cord-269011-230p8rsf	630	8	(	(	-LRB-
cord-269011-230p8rsf	630	9	VLPs	vlp	NNS
cord-269011-230p8rsf	630	10	)	)	-RRB-
cord-269011-230p8rsf	630	11	and	and	CC
cord-269011-230p8rsf	630	12	the	the	DT
cord-269011-230p8rsf	630	13	requirements	requirement	NNS
cord-269011-230p8rsf	630	14	for	for	IN
cord-269011-230p8rsf	630	15	their	-PRON-	PRP$
cord-269011-230p8rsf	630	16	formation	formation	NN
cord-269011-230p8rsf	630	17	were	be	VBD
cord-269011-230p8rsf	630	18	established	establish	VBN
cord-269011-230p8rsf	630	19	by	by	IN
cord-269011-230p8rsf	630	20	the	the	DT
cord-269011-230p8rsf	630	21	coexpression	coexpression	NN
cord-269011-230p8rsf	630	22	of	of	IN
cord-269011-230p8rsf	630	23	the	the	DT
cord-269011-230p8rsf	630	24	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	630	25	structural	structural	JJ
cord-269011-230p8rsf	630	26	proteins	protein	NNS
cord-269011-230p8rsf	630	27	in	in	IN
cord-269011-230p8rsf	630	28	mammalian	mammalian	JJ
cord-269011-230p8rsf	630	29	cells	cell	NNS
cord-269011-230p8rsf	630	30	(	(	-LRB-
cord-269011-230p8rsf	630	31	Vennema	Vennema	NNP
cord-269011-230p8rsf	630	32	et	et	FW
cord-269011-230p8rsf	630	33	al	al	NNP
cord-269011-230p8rsf	630	34	.	.	NNP
cord-269011-230p8rsf	630	35	,	,	,
cord-269011-230p8rsf	630	36	1996	1996	CD
cord-269011-230p8rsf	630	37	)	)	-RRB-
cord-269011-230p8rsf	630	38	.	.	.
cord-269011-230p8rsf	631	1	Membranous	membranous	JJ
cord-269011-230p8rsf	631	2	particles	particle	NNS
cord-269011-230p8rsf	631	3	were	be	VBD
cord-269011-230p8rsf	631	4	assembled	assemble	VBN
cord-269011-230p8rsf	631	5	when	when	WRB
cord-269011-230p8rsf	631	6	the	the	DT
cord-269011-230p8rsf	631	7	MHV	MHV	NNP
cord-269011-230p8rsf	631	8	envelope	envelope	NN
cord-269011-230p8rsf	631	9	proteins	protein	NNS
cord-269011-230p8rsf	631	10	M	M	NNP
cord-269011-230p8rsf	631	11	,	,	,
cord-269011-230p8rsf	631	12	E	E	NNP
cord-269011-230p8rsf	631	13	,	,	,
cord-269011-230p8rsf	631	14	and	and	CC
cord-269011-230p8rsf	631	15	S	S	NNP
cord-269011-230p8rsf	631	16	were	be	VBD
cord-269011-230p8rsf	631	17	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	631	18	,	,	,
cord-269011-230p8rsf	631	19	without	without	IN
cord-269011-230p8rsf	631	20	the	the	DT
cord-269011-230p8rsf	631	21	need	need	NN
cord-269011-230p8rsf	631	22	for	for	IN
cord-269011-230p8rsf	631	23	an	an	DT
cord-269011-230p8rsf	631	24	N	n	CD
cord-269011-230p8rsf	631	25	protein	protein	NN
cord-269011-230p8rsf	631	26	or	or	CC
cord-269011-230p8rsf	631	27	genomic	genomic	JJ
cord-269011-230p8rsf	631	28	RNA	RNA	NNP
cord-269011-230p8rsf	631	29	.	.	.
cord-269011-230p8rsf	632	1	The	the	DT
cord-269011-230p8rsf	632	2	particles	particle	NNS
cord-269011-230p8rsf	632	3	were	be	VBD
cord-269011-230p8rsf	632	4	released	release	VBN
cord-269011-230p8rsf	632	5	from	from	IN
cord-269011-230p8rsf	632	6	the	the	DT
cord-269011-230p8rsf	632	7	cells	cell	NNS
cord-269011-230p8rsf	632	8	and	and	CC
cord-269011-230p8rsf	632	9	,	,	,
cord-269011-230p8rsf	632	10	when	when	WRB
cord-269011-230p8rsf	632	11	examined	examine	VBN
cord-269011-230p8rsf	632	12	under	under	IN
cord-269011-230p8rsf	632	13	the	the	DT
cord-269011-230p8rsf	632	14	electron	electron	NN
cord-269011-230p8rsf	632	15	microscope	microscope	NN
cord-269011-230p8rsf	632	16	,	,	,
cord-269011-230p8rsf	632	17	appeared	appear	VBD
cord-269011-230p8rsf	632	18	to	to	TO
cord-269011-230p8rsf	632	19	be	be	VB
cord-269011-230p8rsf	632	20	morphologically	morphologically	RB
cord-269011-230p8rsf	632	21	indistinguishable	indistinguishable	JJ
cord-269011-230p8rsf	632	22	from	from	IN
cord-269011-230p8rsf	632	23	authentic	authentic	JJ
cord-269011-230p8rsf	632	24	virions	virion	NNS
cord-269011-230p8rsf	632	25	,	,	,
cord-269011-230p8rsf	632	26	that	that	RB
cord-269011-230p8rsf	632	27	is	is	RB
cord-269011-230p8rsf	632	28	,	,	,
cord-269011-230p8rsf	632	29	they	-PRON-	PRP
cord-269011-230p8rsf	632	30	had	have	VBD
cord-269011-230p8rsf	632	31	the	the	DT
cord-269011-230p8rsf	632	32	characteristic	characteristic	JJ
cord-269011-230p8rsf	632	33	shape	shape	NN
cord-269011-230p8rsf	632	34	and	and	CC
cord-269011-230p8rsf	632	35	dimensions	dimension	NNS
cord-269011-230p8rsf	632	36	of	of	IN
cord-269011-230p8rsf	632	37	normal	normal	JJ
cord-269011-230p8rsf	632	38	virions	virion	NNS
cord-269011-230p8rsf	632	39	.	.	.
cord-269011-230p8rsf	633	1	Also	also	RB
cord-269011-230p8rsf	633	2	,	,	,
cord-269011-230p8rsf	633	3	their	-PRON-	PRP$
cord-269011-230p8rsf	633	4	membrane	membrane	NN
cord-269011-230p8rsf	633	5	protein	protein	NN
cord-269011-230p8rsf	633	6	composition	composition	NN
cord-269011-230p8rsf	633	7	was	be	VBD
cord-269011-230p8rsf	633	8	similar	similar	JJ
cord-269011-230p8rsf	633	9	to	to	IN
cord-269011-230p8rsf	633	10	that	that	DT
cord-269011-230p8rsf	633	11	of	of	IN
cord-269011-230p8rsf	633	12	MHV	MHV	NNP
cord-269011-230p8rsf	633	13	,	,	,
cord-269011-230p8rsf	633	14	with	with	IN
cord-269011-230p8rsf	633	15	a	a	DT
cord-269011-230p8rsf	633	16	high	high	JJ
cord-269011-230p8rsf	633	17	abundance	abundance	NN
cord-269011-230p8rsf	633	18	of	of	IN
cord-269011-230p8rsf	633	19	M	M	NNP
cord-269011-230p8rsf	633	20	protein	protein	NN
cord-269011-230p8rsf	633	21	and	and	CC
cord-269011-230p8rsf	633	22	only	only	JJ
cord-269011-230p8rsf	633	23	trace	trace	NN
cord-269011-230p8rsf	633	24	amounts	amount	NNS
cord-269011-230p8rsf	633	25	of	of	IN
cord-269011-230p8rsf	633	26	E	e	NN
cord-269011-230p8rsf	633	27	protein	protein	NN
cord-269011-230p8rsf	633	28	.	.	.
cord-269011-230p8rsf	634	1	Quite	quite	RB
cord-269011-230p8rsf	634	2	surprisingly	surprisingly	RB
cord-269011-230p8rsf	634	3	,	,	,
cord-269011-230p8rsf	634	4	only	only	RB
cord-269011-230p8rsf	634	5	the	the	DT
cord-269011-230p8rsf	634	6	M	M	NNP
cord-269011-230p8rsf	634	7	and	and	CC
cord-269011-230p8rsf	634	8	E	e	NN
cord-269011-230p8rsf	634	9	proteins	protein	NNS
cord-269011-230p8rsf	634	10	were	be	VBD
cord-269011-230p8rsf	634	11	required	require	VBN
cord-269011-230p8rsf	634	12	for	for	IN
cord-269011-230p8rsf	634	13	particle	particle	NN
cord-269011-230p8rsf	634	14	assembly	assembly	NN
cord-269011-230p8rsf	634	15	.	.	.
cord-269011-230p8rsf	635	1	Both	both	DT
cord-269011-230p8rsf	635	2	S	S	NNP
cord-269011-230p8rsf	635	3	and	and	CC
cord-269011-230p8rsf	635	4	N	n	CD
cord-269011-230p8rsf	635	5	proteins	protein	NNS
cord-269011-230p8rsf	635	6	were	be	VBD
cord-269011-230p8rsf	635	7	dispensable	dispensable	JJ
cord-269011-230p8rsf	635	8	for	for	IN
cord-269011-230p8rsf	635	9	particle	particle	NN
cord-269011-230p8rsf	635	10	formation	formation	NN
cord-269011-230p8rsf	635	11	but	but	CC
cord-269011-230p8rsf	635	12	,	,	,
cord-269011-230p8rsf	635	13	whereas	whereas	IN
cord-269011-230p8rsf	635	14	the	the	DT
cord-269011-230p8rsf	635	15	S	S	NNP
cord-269011-230p8rsf	635	16	protein	protein	NN
cord-269011-230p8rsf	635	17	became	become	VBD
cord-269011-230p8rsf	635	18	incorporated	incorporate	VBN
cord-269011-230p8rsf	635	19	when	when	WRB
cord-269011-230p8rsf	635	20	present	present	JJ
cord-269011-230p8rsf	635	21	,	,	,
cord-269011-230p8rsf	635	22	this	this	DT
cord-269011-230p8rsf	635	23	was	be	VBD
cord-269011-230p8rsf	635	24	not	not	RB
cord-269011-230p8rsf	635	25	the	the	DT
cord-269011-230p8rsf	635	26	case	case	NN
cord-269011-230p8rsf	635	27	for	for	IN
cord-269011-230p8rsf	635	28	the	the	DT
cord-269011-230p8rsf	635	29	N	n	CD
cord-269011-230p8rsf	635	30	protein	protein	NN
cord-269011-230p8rsf	635	31	(	(	-LRB-
cord-269011-230p8rsf	635	32	Vennema	Vennema	NNP
cord-269011-230p8rsf	635	33	et	et	FW
cord-269011-230p8rsf	635	34	al	al	NNP
cord-269011-230p8rsf	635	35	.	.	NNP
cord-269011-230p8rsf	635	36	,	,	,
cord-269011-230p8rsf	635	37	1996	1996	CD
cord-269011-230p8rsf	635	38	)	)	-RRB-
cord-269011-230p8rsf	635	39	,	,	,
cord-269011-230p8rsf	635	40	except	except	IN
cord-269011-230p8rsf	635	41	in	in	IN
cord-269011-230p8rsf	635	42	combination	combination	NN
cord-269011-230p8rsf	635	43	with	with	IN
cord-269011-230p8rsf	635	44	(	(	-LRB-
cord-269011-230p8rsf	635	45	defective	defective	JJ
cord-269011-230p8rsf	635	46	)	)	-RRB-
cord-269011-230p8rsf	635	47	genomic	genomic	JJ
cord-269011-230p8rsf	635	48	RNA	RNA	NNP
cord-269011-230p8rsf	635	49	,	,	,
cord-269011-230p8rsf	635	50	in	in	IN
cord-269011-230p8rsf	635	51	which	which	WDT
cord-269011-230p8rsf	635	52	case	case	NN
cord-269011-230p8rsf	635	53	a	a	DT
cord-269011-230p8rsf	635	54	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	635	55	was	be	VBD
cord-269011-230p8rsf	635	56	coassembled	coassemble	VBN
cord-269011-230p8rsf	635	57	(	(	-LRB-
cord-269011-230p8rsf	635	58	Bos	Bos	NNP
cord-269011-230p8rsf	635	59	et	et	NNP
cord-269011-230p8rsf	635	60	al	al	NNP
cord-269011-230p8rsf	635	61	.	.	NNP
cord-269011-230p8rsf	635	62	,	,	,
cord-269011-230p8rsf	635	63	1996	1996	CD
cord-269011-230p8rsf	635	64	;	;	:
cord-269011-230p8rsf	635	65	Kim	Kim	NNP
cord-269011-230p8rsf	635	66	et	et	NNP
cord-269011-230p8rsf	635	67	al	al	NNP
cord-269011-230p8rsf	635	68	.	.	NNP
cord-269011-230p8rsf	635	69	,	,	,
cord-269011-230p8rsf	635	70	1997	1997	CD
cord-269011-230p8rsf	635	71	)	)	-RRB-
cord-269011-230p8rsf	635	72	.	.	.
cord-269011-230p8rsf	636	1	Individual	individual	JJ
cord-269011-230p8rsf	636	2	expression	expression	NN
cord-269011-230p8rsf	636	3	of	of	IN
cord-269011-230p8rsf	636	4	the	the	DT
cord-269011-230p8rsf	636	5	M	M	NNP
cord-269011-230p8rsf	636	6	or	or	CC
cord-269011-230p8rsf	636	7	the	the	DT
cord-269011-230p8rsf	636	8	E	e	NN
cord-269011-230p8rsf	636	9	protein	protein	NN
cord-269011-230p8rsf	636	10	in	in	IN
cord-269011-230p8rsf	636	11	cells	cell	NNS
cord-269011-230p8rsf	636	12	did	do	VBD
cord-269011-230p8rsf	636	13	not	not	RB
cord-269011-230p8rsf	636	14	give	give	VB
cord-269011-230p8rsf	636	15	rise	rise	NN
cord-269011-230p8rsf	636	16	to	to	IN
cord-269011-230p8rsf	636	17	formation	formation	NN
cord-269011-230p8rsf	636	18	of	of	IN
cord-269011-230p8rsf	636	19	VLPs	vlp	NNS
cord-269011-230p8rsf	636	20	although	although	IN
cord-269011-230p8rsf	636	21	E	e	NN
cord-269011-230p8rsf	636	22	protein	protein	NN
cord-269011-230p8rsf	636	23	synthesis	synthesis	NN
cord-269011-230p8rsf	636	24	by	by	IN
cord-269011-230p8rsf	636	25	itself	-PRON-	PRP
cord-269011-230p8rsf	636	26	led	lead	VBD
cord-269011-230p8rsf	636	27	to	to	IN
cord-269011-230p8rsf	636	28	the	the	DT
cord-269011-230p8rsf	636	29	secretion	secretion	NN
cord-269011-230p8rsf	636	30	of	of	IN
cord-269011-230p8rsf	636	31	E	e	NN
cord-269011-230p8rsf	636	32	-	-	JJ
cord-269011-230p8rsf	636	33	containing	contain	VBG
cord-269011-230p8rsf	636	34	vesicles	vesicle	NNS
cord-269011-230p8rsf	636	35	(	(	-LRB-
cord-269011-230p8rsf	636	36	Corse	Corse	NNP
cord-269011-230p8rsf	636	37	and	and	CC
cord-269011-230p8rsf	636	38	Machamer	Machamer	NNP
cord-269011-230p8rsf	636	39	,	,	,
cord-269011-230p8rsf	636	40	2000	2000	CD
cord-269011-230p8rsf	636	41	;	;	:
cord-269011-230p8rsf	637	1	Maeda	Maeda	NNP
cord-269011-230p8rsf	637	2	et	et	NNP
cord-269011-230p8rsf	637	3	al	al	NNP
cord-269011-230p8rsf	637	4	.	.	NNP
cord-269011-230p8rsf	637	5	,	,	,
cord-269011-230p8rsf	637	6	1999	1999	CD
cord-269011-230p8rsf	637	7	)	)	-RRB-
cord-269011-230p8rsf	637	8	.	.	.
cord-269011-230p8rsf	638	1	The	the	DT
cord-269011-230p8rsf	638	2	nature	nature	NN
cord-269011-230p8rsf	638	3	of	of	IN
cord-269011-230p8rsf	638	4	these	these	DT
cord-269011-230p8rsf	638	5	particles	particle	NNS
cord-269011-230p8rsf	638	6	has	have	VBZ
cord-269011-230p8rsf	638	7	not	not	RB
cord-269011-230p8rsf	638	8	been	be	VBN
cord-269011-230p8rsf	638	9	characterized	characterize	VBN
cord-269011-230p8rsf	638	10	in	in	IN
cord-269011-230p8rsf	638	11	much	much	JJ
cord-269011-230p8rsf	638	12	detail	detail	NN
cord-269011-230p8rsf	638	13	;	;	:
cord-269011-230p8rsf	638	14	the	the	DT
cord-269011-230p8rsf	638	15	vesicles	vesicle	NNS
cord-269011-230p8rsf	638	16	induced	induce	VBN
cord-269011-230p8rsf	638	17	by	by	IN
cord-269011-230p8rsf	638	18	MHV	MHV	NNP
cord-269011-230p8rsf	638	19	E	e	NN
cord-269011-230p8rsf	638	20	sedimented	sediment	VBD
cord-269011-230p8rsf	638	21	slightly	slightly	RB
cord-269011-230p8rsf	638	22	slower	slow	JJR
cord-269011-230p8rsf	638	23	than	than	IN
cord-269011-230p8rsf	638	24	virions	virion	NNS
cord-269011-230p8rsf	638	25	(	(	-LRB-
cord-269011-230p8rsf	639	1	Maeda	Maeda	NNP
cord-269011-230p8rsf	639	2	et	et	NNP
cord-269011-230p8rsf	639	3	al	al	NNP
cord-269011-230p8rsf	639	4	.	.	NNP
cord-269011-230p8rsf	639	5	,	,	,
cord-269011-230p8rsf	639	6	1999	1999	CD
cord-269011-230p8rsf	639	7	)	)	-RRB-
cord-269011-230p8rsf	639	8	whereas	whereas	IN
cord-269011-230p8rsf	639	9	the	the	DT
cord-269011-230p8rsf	639	10	particles	particle	NNS
cord-269011-230p8rsf	639	11	obtained	obtain	VBN
cord-269011-230p8rsf	639	12	with	with	IN
cord-269011-230p8rsf	639	13	IBV	IBV	NNP
cord-269011-230p8rsf	639	14	E	E	NNP
cord-269011-230p8rsf	639	15	had	have	VBD
cord-269011-230p8rsf	639	16	about	about	IN
cord-269011-230p8rsf	639	17	the	the	DT
cord-269011-230p8rsf	639	18	same	same	JJ
cord-269011-230p8rsf	639	19	density	density	NN
cord-269011-230p8rsf	639	20	as	as	IN
cord-269011-230p8rsf	639	21	virions	virion	NNS
cord-269011-230p8rsf	639	22	(	(	-LRB-
cord-269011-230p8rsf	639	23	Corse	Corse	NNP
cord-269011-230p8rsf	639	24	and	and	CC
cord-269011-230p8rsf	639	25	Machamer	Machamer	NNP
cord-269011-230p8rsf	639	26	,	,	,
cord-269011-230p8rsf	639	27	2000	2000	CD
cord-269011-230p8rsf	639	28	)	)	-RRB-
cord-269011-230p8rsf	639	29	.	.	.
cord-269011-230p8rsf	640	1	Besides	besides	IN
cord-269011-230p8rsf	640	2	for	for	IN
cord-269011-230p8rsf	640	3	MHV	MHV	NNP
cord-269011-230p8rsf	640	4	and	and	CC
cord-269011-230p8rsf	640	5	IBV	IBV	NNP
cord-269011-230p8rsf	640	6	,	,	,
cord-269011-230p8rsf	640	7	VLPs	vlp	NNS
cord-269011-230p8rsf	640	8	have	have	VBP
cord-269011-230p8rsf	640	9	so	so	RB
cord-269011-230p8rsf	640	10	far	far	RB
cord-269011-230p8rsf	640	11	been	be	VBN
cord-269011-230p8rsf	640	12	described	describe	VBN
cord-269011-230p8rsf	640	13	for	for	IN
cord-269011-230p8rsf	640	14	BCoV	BCoV	NNP
cord-269011-230p8rsf	640	15	(	(	-LRB-
cord-269011-230p8rsf	640	16	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	640	17	et	et	NNP
cord-269011-230p8rsf	640	18	al	al	NNP
cord-269011-230p8rsf	640	19	.	.	NNP
cord-269011-230p8rsf	640	20	,	,	,
cord-269011-230p8rsf	640	21	1998b	1998b	CD
cord-269011-230p8rsf	640	22	)	)	-RRB-
cord-269011-230p8rsf	640	23	,	,	,
cord-269011-230p8rsf	640	24	FIPV	FIPV	NNP
cord-269011-230p8rsf	640	25	,	,	,
cord-269011-230p8rsf	640	26	and	and	CC
cord-269011-230p8rsf	640	27	TGEV	TGEV	NNP
cord-269011-230p8rsf	640	28	(	(	-LRB-
cord-269011-230p8rsf	640	29	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	640	30	et	et	NNP
cord-269011-230p8rsf	640	31	al	al	NNP
cord-269011-230p8rsf	640	32	.	.	NNP
cord-269011-230p8rsf	640	33	,	,	,
cord-269011-230p8rsf	640	34	1998b	1998b	CD
cord-269011-230p8rsf	640	35	)	)	-RRB-
cord-269011-230p8rsf	640	36	.	.	.
cord-269011-230p8rsf	641	1	The	the	DT
cord-269011-230p8rsf	641	2	observations	observation	NNS
cord-269011-230p8rsf	641	3	demonstrate	demonstrate	VBP
cord-269011-230p8rsf	641	4	the	the	DT
cord-269011-230p8rsf	641	5	unique	unique	JJ
cord-269011-230p8rsf	641	6	budding	budding	JJ
cord-269011-230p8rsf	641	7	mechanism	mechanism	NN
cord-269011-230p8rsf	641	8	of	of	IN
cord-269011-230p8rsf	641	9	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	641	10	,	,	,
cord-269011-230p8rsf	641	11	which	which	WDT
cord-269011-230p8rsf	641	12	is	be	VBZ
cord-269011-230p8rsf	641	13	dependent	dependent	JJ
cord-269011-230p8rsf	641	14	solely	solely	RB
cord-269011-230p8rsf	641	15	on	on	IN
cord-269011-230p8rsf	641	16	the	the	DT
cord-269011-230p8rsf	641	17	envelope	envelope	NN
cord-269011-230p8rsf	641	18	proteins	protein	NNS
cord-269011-230p8rsf	641	19	M	M	NNP
cord-269011-230p8rsf	641	20	and	and	CC
cord-269011-230p8rsf	641	21	E	E	NNP
cord-269011-230p8rsf	641	22	but	but	CC
cord-269011-230p8rsf	641	23	independent	independent	JJ
cord-269011-230p8rsf	641	24	of	of	IN
cord-269011-230p8rsf	641	25	a	a	DT
cord-269011-230p8rsf	641	26	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	641	27	.	.	.
cord-269011-230p8rsf	642	1	Somewhat	somewhat	RB
cord-269011-230p8rsf	642	2	similar	similar	JJ
cord-269011-230p8rsf	642	3	observations	observation	NNS
cord-269011-230p8rsf	642	4	have	have	VBP
cord-269011-230p8rsf	642	5	been	be	VBN
cord-269011-230p8rsf	642	6	described	describe	VBN
cord-269011-230p8rsf	642	7	for	for	IN
cord-269011-230p8rsf	642	8	the	the	DT
cord-269011-230p8rsf	642	9	flavivirus	flavivirus	JJ
cord-269011-230p8rsf	642	10	tick	tick	NN
cord-269011-230p8rsf	642	11	-	-	HYPH
cord-269011-230p8rsf	642	12	borne	bear	VBN
cord-269011-230p8rsf	642	13	encephalitis	encephalitis	JJ
cord-269011-230p8rsf	642	14	virus	virus	NN
cord-269011-230p8rsf	642	15	and	and	CC
cord-269011-230p8rsf	642	16	for	for	IN
cord-269011-230p8rsf	642	17	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	642	18	B	B	NNP
cord-269011-230p8rsf	642	19	virus	virus	NN
cord-269011-230p8rsf	642	20	,	,	,
cord-269011-230p8rsf	642	21	which	which	WDT
cord-269011-230p8rsf	642	22	also	also	RB
cord-269011-230p8rsf	642	23	produce	produce	VBP
cord-269011-230p8rsf	642	24	proteolipid	proteolipid	NN
cord-269011-230p8rsf	642	25	particles	particle	NNS
cord-269011-230p8rsf	642	26	on	on	IN
cord-269011-230p8rsf	642	27	expression	expression	NN
cord-269011-230p8rsf	642	28	of	of	IN
cord-269011-230p8rsf	642	29	their	-PRON-	PRP$
cord-269011-230p8rsf	642	30	envelope	envelope	NN
cord-269011-230p8rsf	642	31	proteins	protein	NNS
cord-269011-230p8rsf	642	32	preM	preM	NNS
cord-269011-230p8rsf	642	33	and	and	CC
cord-269011-230p8rsf	642	34	E	E	NNP
cord-269011-230p8rsf	642	35	(	(	-LRB-
cord-269011-230p8rsf	642	36	Allison	Allison	NNP
cord-269011-230p8rsf	642	37	et	et	NNP
cord-269011-230p8rsf	642	38	al	al	NNP
cord-269011-230p8rsf	642	39	.	.	NNP
cord-269011-230p8rsf	642	40	,	,	,
cord-269011-230p8rsf	642	41	1995	1995	CD
cord-269011-230p8rsf	642	42	;	;	:
cord-269011-230p8rsf	642	43	Mason	Mason	NNP
cord-269011-230p8rsf	642	44	et	et	NNP
cord-269011-230p8rsf	642	45	al	al	NNP
cord-269011-230p8rsf	642	46	.	.	NNP
cord-269011-230p8rsf	642	47	,	,	,
cord-269011-230p8rsf	642	48	1991	1991	CD
cord-269011-230p8rsf	642	49	)	)	-RRB-
cord-269011-230p8rsf	642	50	and	and	CC
cord-269011-230p8rsf	642	51	S	S	NNP
cord-269011-230p8rsf	642	52	(	(	-LRB-
cord-269011-230p8rsf	642	53	Patzer	Patzer	NNP
cord-269011-230p8rsf	642	54	et	et	NNP
cord-269011-230p8rsf	642	55	al	al	NNP
cord-269011-230p8rsf	642	56	.	.	NNP
cord-269011-230p8rsf	642	57	,	,	,
cord-269011-230p8rsf	642	58	1986	1986	CD
cord-269011-230p8rsf	642	59	;	;	:
cord-269011-230p8rsf	642	60	Simon	Simon	NNP
cord-269011-230p8rsf	642	61	et	et	NNP
cord-269011-230p8rsf	642	62	al	al	NNP
cord-269011-230p8rsf	642	63	.	.	NNP
cord-269011-230p8rsf	642	64	,	,	,
cord-269011-230p8rsf	642	65	1988	1988	CD
cord-269011-230p8rsf	642	66	)	)	-RRB-
cord-269011-230p8rsf	642	67	,	,	,
cord-269011-230p8rsf	642	68	respectively	respectively	RB
cord-269011-230p8rsf	642	69	,	,	,
cord-269011-230p8rsf	642	70	but	but	CC
cord-269011-230p8rsf	642	71	these	these	DT
cord-269011-230p8rsf	642	72	particles	particle	NNS
cord-269011-230p8rsf	642	73	are	be	VBP
cord-269011-230p8rsf	642	74	much	much	RB
cord-269011-230p8rsf	642	75	smaller	small	JJR
cord-269011-230p8rsf	642	76	than	than	IN
cord-269011-230p8rsf	642	77	the	the	DT
cord-269011-230p8rsf	642	78	corresponding	correspond	VBG
cord-269011-230p8rsf	642	79	virions	virion	NNS
cord-269011-230p8rsf	642	80	.	.	.
cord-269011-230p8rsf	643	1	In	in	IN
cord-269011-230p8rsf	643	2	contrast	contrast	NN
cord-269011-230p8rsf	643	3	,	,	,
cord-269011-230p8rsf	643	4	particles	particle	NNS
cord-269011-230p8rsf	643	5	with	with	IN
cord-269011-230p8rsf	643	6	the	the	DT
cord-269011-230p8rsf	643	7	typical	typical	JJ
cord-269011-230p8rsf	643	8	,	,	,
cord-269011-230p8rsf	643	9	large	large	JJ
cord-269011-230p8rsf	643	10	size	size	NN
cord-269011-230p8rsf	643	11	of	of	IN
cord-269011-230p8rsf	643	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	643	13	are	be	VBP
cord-269011-230p8rsf	643	14	acquired	acquire	VBN
cord-269011-230p8rsf	643	15	by	by	IN
cord-269011-230p8rsf	643	16	the	the	DT
cord-269011-230p8rsf	643	17	concerted	concerted	JJ
cord-269011-230p8rsf	643	18	action	action	NN
cord-269011-230p8rsf	643	19	of	of	IN
cord-269011-230p8rsf	643	20	just	just	RB
cord-269011-230p8rsf	643	21	the	the	DT
cord-269011-230p8rsf	643	22	proteins	protein	NNS
cord-269011-230p8rsf	643	23	M	M	NNP
cord-269011-230p8rsf	643	24	and	and	CC
cord-269011-230p8rsf	643	25	E	E	NNP
cord-269011-230p8rsf	643	26	(	(	-LRB-
cord-269011-230p8rsf	643	27	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	643	28	et	et	NNP
cord-269011-230p8rsf	643	29	al	al	NNP
cord-269011-230p8rsf	643	30	.	.	NNP
cord-269011-230p8rsf	643	31	,	,	,
cord-269011-230p8rsf	643	32	1998b	1998b	CD
cord-269011-230p8rsf	643	33	;	;	:
cord-269011-230p8rsf	643	34	Vennema	Vennema	NNP
cord-269011-230p8rsf	643	35	et	et	FW
cord-269011-230p8rsf	643	36	al	al	NNP
cord-269011-230p8rsf	643	37	.	.	NNP
cord-269011-230p8rsf	643	38	,	,	,
cord-269011-230p8rsf	643	39	1996	1996	CD
cord-269011-230p8rsf	643	40	)	)	-RRB-
cord-269011-230p8rsf	643	41	.	.	.
cord-269011-230p8rsf	644	1	Budding	bud	VBG
cord-269011-230p8rsf	644	2	of	of	IN
cord-269011-230p8rsf	644	3	enveloped	envelop	VBN
cord-269011-230p8rsf	644	4	viruses	virus	NNS
cord-269011-230p8rsf	644	5	generally	generally	RB
cord-269011-230p8rsf	644	6	requires	require	VBZ
cord-269011-230p8rsf	644	7	a	a	DT
cord-269011-230p8rsf	644	8	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	644	9	(	(	-LRB-
cord-269011-230p8rsf	644	10	for	for	IN
cord-269011-230p8rsf	644	11	a	a	DT
cord-269011-230p8rsf	644	12	review	review	NN
cord-269011-230p8rsf	644	13	see	see	VB
cord-269011-230p8rsf	644	14	Garoff	Garoff	NNP
cord-269011-230p8rsf	644	15	et	et	NNP
cord-269011-230p8rsf	644	16	al	al	NNP
cord-269011-230p8rsf	644	17	.	.	NNP
cord-269011-230p8rsf	644	18	,	,	,
cord-269011-230p8rsf	644	19	1998	1998	CD
cord-269011-230p8rsf	644	20	)	)	-RRB-
cord-269011-230p8rsf	644	21	.	.	.
cord-269011-230p8rsf	645	1	For	for	IN
cord-269011-230p8rsf	645	2	retroviruses	retrovirus	NNS
cord-269011-230p8rsf	645	3	the	the	DT
cord-269011-230p8rsf	645	4	Gag	Gag	NNP
cord-269011-230p8rsf	645	5	protein	protein	NN
cord-269011-230p8rsf	645	6	,	,	,
cord-269011-230p8rsf	645	7	the	the	DT
cord-269011-230p8rsf	645	8	precursor	precursor	NN
cord-269011-230p8rsf	645	9	to	to	IN
cord-269011-230p8rsf	645	10	the	the	DT
cord-269011-230p8rsf	645	11	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	645	12	,	,	,
cord-269011-230p8rsf	645	13	is	be	VBZ
cord-269011-230p8rsf	645	14	all	all	DT
cord-269011-230p8rsf	645	15	that	that	WDT
cord-269011-230p8rsf	645	16	is	be	VBZ
cord-269011-230p8rsf	645	17	needed	need	VBN
cord-269011-230p8rsf	645	18	to	to	TO
cord-269011-230p8rsf	645	19	obtain	obtain	VB
cord-269011-230p8rsf	645	20	particles	particle	NNS
cord-269011-230p8rsf	645	21	resembling	resemble	VBG
cord-269011-230p8rsf	645	22	immature	immature	JJ
cord-269011-230p8rsf	645	23	virions	virion	NNS
cord-269011-230p8rsf	645	24	;	;	:
cord-269011-230p8rsf	645	25	the	the	DT
cord-269011-230p8rsf	645	26	Env	Env	NNP
cord-269011-230p8rsf	645	27	protein	protein	NN
cord-269011-230p8rsf	645	28	is	be	VBZ
cord-269011-230p8rsf	645	29	dispensable	dispensable	JJ
cord-269011-230p8rsf	645	30	.	.	.
cord-269011-230p8rsf	646	1	Budding	bud	VBG
cord-269011-230p8rsf	646	2	of	of	IN
cord-269011-230p8rsf	646	3	alphaviruses	alphavirus	NNS
cord-269011-230p8rsf	646	4	,	,	,
cord-269011-230p8rsf	646	5	on	on	IN
cord-269011-230p8rsf	646	6	the	the	DT
cord-269011-230p8rsf	646	7	other	other	JJ
cord-269011-230p8rsf	646	8	hand	hand	NN
cord-269011-230p8rsf	646	9	,	,	,
cord-269011-230p8rsf	646	10	requires	require	VBZ
cord-269011-230p8rsf	646	11	both	both	CC
cord-269011-230p8rsf	646	12	the	the	DT
cord-269011-230p8rsf	646	13	envelope	envelope	NN
cord-269011-230p8rsf	646	14	proteins	protein	NNS
cord-269011-230p8rsf	646	15	and	and	CC
cord-269011-230p8rsf	646	16	the	the	DT
cord-269011-230p8rsf	646	17	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	646	18	.	.	.
cord-269011-230p8rsf	647	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	647	2	,	,	,
cord-269011-230p8rsf	647	3	the	the	DT
cord-269011-230p8rsf	647	4	same	same	JJ
cord-269011-230p8rsf	647	5	appears	appear	VBZ
cord-269011-230p8rsf	647	6	to	to	TO
cord-269011-230p8rsf	647	7	hold	hold	VB
cord-269011-230p8rsf	647	8	true	true	JJ
cord-269011-230p8rsf	647	9	for	for	IN
cord-269011-230p8rsf	647	10	arteriviruses	arteriviruse	NNS
cord-269011-230p8rsf	647	11	(	(	-LRB-
cord-269011-230p8rsf	647	12	R.	R.	NNP
cord-269011-230p8rsf	647	13	Wieringa	Wieringa	NNP
cord-269011-230p8rsf	647	14	,	,	,
cord-269011-230p8rsf	647	15	A.	a.	NN
cord-269011-230p8rsf	647	16	A.	a.	NN
cord-269011-230p8rsf	647	17	F.	f.	NN
cord-269011-230p8rsf	647	18	de	de	FW
cord-269011-230p8rsf	647	19	Vries	Vries	NNP
cord-269011-230p8rsf	647	20	,	,	,
cord-269011-230p8rsf	647	21	and	and	CC
cord-269011-230p8rsf	647	22	P.	P.	NNP
cord-269011-230p8rsf	647	23	J.	J.	NNP
cord-269011-230p8rsf	647	24	M.	M.	NNP
cord-269011-230p8rsf	647	25	Rottier	Rottier	NNP
cord-269011-230p8rsf	647	26	,	,	,
cord-269011-230p8rsf	647	27	unpublished	unpublished	JJ
cord-269011-230p8rsf	647	28	observations	observation	NNS
cord-269011-230p8rsf	647	29	)	)	-RRB-
cord-269011-230p8rsf	647	30	,	,	,
cord-269011-230p8rsf	647	31	which	which	WDT
cord-269011-230p8rsf	647	32	are	be	VBP
cord-269011-230p8rsf	647	33	closely	closely	RB
cord-269011-230p8rsf	647	34	related	related	JJ
cord-269011-230p8rsf	647	35	to	to	IN
cord-269011-230p8rsf	647	36	the	the	DT
cord-269011-230p8rsf	647	37	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	647	38	,	,	,
cord-269011-230p8rsf	647	39	share	share	VB
cord-269011-230p8rsf	647	40	with	with	IN
cord-269011-230p8rsf	647	41	them	-PRON-	PRP
cord-269011-230p8rsf	647	42	a	a	DT
cord-269011-230p8rsf	647	43	triple	triple	RB
cord-269011-230p8rsf	647	44	-	-	HYPH
cord-269011-230p8rsf	647	45	spanning	span	VBG
cord-269011-230p8rsf	647	46	envelope	envelope	NN
cord-269011-230p8rsf	647	47	protein	protein	NN
cord-269011-230p8rsf	647	48	,	,	,
cord-269011-230p8rsf	647	49	and	and	CC
cord-269011-230p8rsf	647	50	bud	bud	NN
cord-269011-230p8rsf	647	51	into	into	IN
cord-269011-230p8rsf	647	52	early	early	JJ
cord-269011-230p8rsf	647	53	membranes	membrane	NNS
cord-269011-230p8rsf	647	54	of	of	IN
cord-269011-230p8rsf	647	55	the	the	DT
cord-269011-230p8rsf	647	56	secretory	secretory	JJ
cord-269011-230p8rsf	647	57	pathway	pathway	NN
cord-269011-230p8rsf	647	58	,	,	,
cord-269011-230p8rsf	647	59	like	like	IN
cord-269011-230p8rsf	647	60	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	647	61	but	but	CC
cord-269011-230p8rsf	647	62	unlike	unlike	IN
cord-269011-230p8rsf	647	63	alphaviruses	alphavirus	NNS
cord-269011-230p8rsf	647	64	.	.	.
cord-269011-230p8rsf	648	1	It	-PRON-	PRP
cord-269011-230p8rsf	648	2	is	be	VBZ
cord-269011-230p8rsf	648	3	unknown	unknown	JJ
cord-269011-230p8rsf	648	4	how	how	WRB
cord-269011-230p8rsf	648	5	the	the	DT
cord-269011-230p8rsf	648	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	648	7	M	m	NN
cord-269011-230p8rsf	648	8	and	and	CC
cord-269011-230p8rsf	648	9	E	e	NN
cord-269011-230p8rsf	648	10	proteins	protein	NNS
cord-269011-230p8rsf	648	11	cooperate	cooperate	VBP
cord-269011-230p8rsf	648	12	in	in	IN
cord-269011-230p8rsf	648	13	budding	bud	VBG
cord-269011-230p8rsf	648	14	.	.	.
cord-269011-230p8rsf	649	1	As	as	IN
cord-269011-230p8rsf	649	2	the	the	DT
cord-269011-230p8rsf	649	3	extensive	extensive	JJ
cord-269011-230p8rsf	649	4	electron	electron	NN
cord-269011-230p8rsf	649	5	microscopy	microscopy	NN
cord-269011-230p8rsf	649	6	work	work	NN
cord-269011-230p8rsf	649	7	with	with	IN
cord-269011-230p8rsf	649	8	M	M	NNP
cord-269011-230p8rsf	649	9	proteins	protein	NNS
cord-269011-230p8rsf	649	10	from	from	IN
cord-269011-230p8rsf	649	11	various	various	JJ
cord-269011-230p8rsf	649	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	649	13	gave	give	VBD
cord-269011-230p8rsf	649	14	no	no	DT
cord-269011-230p8rsf	649	15	indications	indication	NNS
cord-269011-230p8rsf	649	16	that	that	IN
cord-269011-230p8rsf	649	17	this	this	DT
cord-269011-230p8rsf	649	18	protein	protein	NN
cord-269011-230p8rsf	649	19	causes	cause	VBZ
cord-269011-230p8rsf	649	20	membrane	membrane	NN
cord-269011-230p8rsf	649	21	bulging	bulge	VBG
cord-269011-230p8rsf	649	22	by	by	IN
cord-269011-230p8rsf	649	23	itself	-PRON-	PRP
cord-269011-230p8rsf	649	24	,	,	,
cord-269011-230p8rsf	649	25	it	-PRON-	PRP
cord-269011-230p8rsf	649	26	is	be	VBZ
cord-269011-230p8rsf	649	27	believed	believe	VBN
cord-269011-230p8rsf	649	28	that	that	IN
cord-269011-230p8rsf	649	29	the	the	DT
cord-269011-230p8rsf	649	30	function	function	NN
cord-269011-230p8rsf	649	31	of	of	IN
cord-269011-230p8rsf	649	32	the	the	DT
cord-269011-230p8rsf	649	33	E	e	NN
cord-269011-230p8rsf	649	34	protein	protein	NN
cord-269011-230p8rsf	649	35	in	in	IN
cord-269011-230p8rsf	649	36	coronavirus	coronavirus	NN
cord-269011-230p8rsf	649	37	budding	budding	NN
cord-269011-230p8rsf	649	38	is	be	VBZ
cord-269011-230p8rsf	649	39	in	in	IN
cord-269011-230p8rsf	649	40	the	the	DT
cord-269011-230p8rsf	649	41	induction	induction	NN
cord-269011-230p8rsf	649	42	of	of	IN
cord-269011-230p8rsf	649	43	curvature	curvature	NN
cord-269011-230p8rsf	649	44	in	in	IN
cord-269011-230p8rsf	649	45	the	the	DT
cord-269011-230p8rsf	649	46	M	M	NNP
cord-269011-230p8rsf	649	47	protein	protein	NN
cord-269011-230p8rsf	649	48	lattice	lattice	NN
cord-269011-230p8rsf	649	49	(	(	-LRB-
cord-269011-230p8rsf	649	50	see	see	VB
cord-269011-230p8rsf	649	51	later	later	RBR
cord-269011-230p8rsf	649	52	)	)	-RRB-
cord-269011-230p8rsf	649	53	and	and	CC
cord-269011-230p8rsf	649	54	the	the	DT
cord-269011-230p8rsf	649	55	subsequent	subsequent	JJ
cord-269011-230p8rsf	649	56	budding	budding	NN
cord-269011-230p8rsf	649	57	of	of	IN
cord-269011-230p8rsf	649	58	the	the	DT
cord-269011-230p8rsf	649	59	membrane	membrane	NN
cord-269011-230p8rsf	649	60	(	(	-LRB-
cord-269011-230p8rsf	649	61	Vennema	Vennema	NNP
cord-269011-230p8rsf	649	62	et	et	FW
cord-269011-230p8rsf	649	63	al	al	NNP
cord-269011-230p8rsf	649	64	.	.	NNP
cord-269011-230p8rsf	649	65	,	,	,
cord-269011-230p8rsf	649	66	1996	1996	CD
cord-269011-230p8rsf	649	67	)	)	-RRB-
cord-269011-230p8rsf	649	68	.	.	.
cord-269011-230p8rsf	650	1	By	by	IN
cord-269011-230p8rsf	650	2	its	-PRON-	PRP$
cord-269011-230p8rsf	650	3	low	low	JJ
cord-269011-230p8rsf	650	4	abundance	abundance	NN
cord-269011-230p8rsf	650	5	in	in	IN
cord-269011-230p8rsf	650	6	the	the	DT
cord-269011-230p8rsf	650	7	virion	virion	NN
cord-269011-230p8rsf	650	8	,	,	,
cord-269011-230p8rsf	650	9	the	the	DT
cord-269011-230p8rsf	650	10	E	e	NN
cord-269011-230p8rsf	650	11	protein	protein	NN
cord-269011-230p8rsf	650	12	does	do	VBZ
cord-269011-230p8rsf	650	13	not	not	RB
cord-269011-230p8rsf	650	14	seem	seem	VB
cord-269011-230p8rsf	650	15	to	to	TO
cord-269011-230p8rsf	650	16	serve	serve	VB
cord-269011-230p8rsf	650	17	a	a	DT
cord-269011-230p8rsf	650	18	genuine	genuine	JJ
cord-269011-230p8rsf	650	19	structural	structural	JJ
cord-269011-230p8rsf	650	20	function	function	NN
cord-269011-230p8rsf	650	21	in	in	IN
cord-269011-230p8rsf	650	22	that	that	IN
cord-269011-230p8rsf	650	23	it	-PRON-	PRP
cord-269011-230p8rsf	650	24	occupies	occupy	VBZ
cord-269011-230p8rsf	650	25	frequent	frequent	JJ
cord-269011-230p8rsf	650	26	,	,	,
cord-269011-230p8rsf	650	27	regular	regular	JJ
cord-269011-230p8rsf	650	28	positions	position	NNS
cord-269011-230p8rsf	650	29	in	in	IN
cord-269011-230p8rsf	650	30	the	the	DT
cord-269011-230p8rsf	650	31	M	M	NNP
cord-269011-230p8rsf	650	32	protein	protein	NN
cord-269011-230p8rsf	650	33	framework	framework	NN
cord-269011-230p8rsf	650	34	.	.	.
cord-269011-230p8rsf	651	1	Consistent	consistent	JJ
cord-269011-230p8rsf	651	2	with	with	IN
cord-269011-230p8rsf	651	3	an	an	DT
cord-269011-230p8rsf	651	4	important	important	JJ
cord-269011-230p8rsf	651	5	role	role	NN
cord-269011-230p8rsf	651	6	of	of	IN
cord-269011-230p8rsf	651	7	the	the	DT
cord-269011-230p8rsf	651	8	E	e	NN
cord-269011-230p8rsf	651	9	protein	protein	NN
cord-269011-230p8rsf	651	10	in	in	IN
cord-269011-230p8rsf	651	11	particle	particle	NN
cord-269011-230p8rsf	651	12	morphogenesis	morphogenesis	NN
cord-269011-230p8rsf	651	13	,	,	,
cord-269011-230p8rsf	651	14	mutations	mutation	NNS
cord-269011-230p8rsf	651	15	in	in	IN
cord-269011-230p8rsf	651	16	its	-PRON-	PRP$
cord-269011-230p8rsf	651	17	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	651	18	carboxy	carboxy	JJ
cord-269011-230p8rsf	651	19	-	-	HYPH
cord-269011-230p8rsf	651	20	terminal	terminal	NN
cord-269011-230p8rsf	651	21	part	part	NN
cord-269011-230p8rsf	651	22	,	,	,
cord-269011-230p8rsf	651	23	introduced	introduce	VBN
cord-269011-230p8rsf	651	24	by	by	IN
cord-269011-230p8rsf	651	25	targeted	target	VBN
cord-269011-230p8rsf	651	26	recombination	recombination	NN
cord-269011-230p8rsf	651	27	into	into	IN
cord-269011-230p8rsf	651	28	the	the	DT
cord-269011-230p8rsf	651	29	MHV	MHV	NNP
cord-269011-230p8rsf	651	30	genome	genome	NN
cord-269011-230p8rsf	651	31	,	,	,
cord-269011-230p8rsf	651	32	yielded	yield	VBD
cord-269011-230p8rsf	651	33	thermolabile	thermolabile	NN
cord-269011-230p8rsf	651	34	viruses	virus	NNS
cord-269011-230p8rsf	651	35	one	one	CD
cord-269011-230p8rsf	651	36	of	of	IN
cord-269011-230p8rsf	651	37	which	which	WDT
cord-269011-230p8rsf	651	38	showed	show	VBD
cord-269011-230p8rsf	651	39	aberrant	aberrant	JJ
cord-269011-230p8rsf	651	40	virion	virion	NN
cord-269011-230p8rsf	651	41	morphology	morphology	NN
cord-269011-230p8rsf	651	42	with	with	IN
cord-269011-230p8rsf	651	43	pinched	pinch	VBN
cord-269011-230p8rsf	651	44	and	and	CC
cord-269011-230p8rsf	651	45	elongated	elongated	JJ
cord-269011-230p8rsf	651	46	shapes	shape	NNS
cord-269011-230p8rsf	651	47	when	when	WRB
cord-269011-230p8rsf	651	48	viewed	view	VBN
cord-269011-230p8rsf	651	49	in	in	IN
cord-269011-230p8rsf	651	50	the	the	DT
cord-269011-230p8rsf	651	51	electron	electron	NN
cord-269011-230p8rsf	651	52	microscope	microscope	NN
cord-269011-230p8rsf	651	53	(	(	-LRB-
cord-269011-230p8rsf	651	54	Fischer	Fischer	NNP
cord-269011-230p8rsf	651	55	et	et	NNP
cord-269011-230p8rsf	651	56	al	al	NNP
cord-269011-230p8rsf	651	57	.	.	NNP
cord-269011-230p8rsf	651	58	,	,	,
cord-269011-230p8rsf	651	59	1998	1998	CD
cord-269011-230p8rsf	651	60	)	)	-RRB-
cord-269011-230p8rsf	651	61	.	.	.
cord-269011-230p8rsf	652	1	Revertant	Revertant	NNP
cord-269011-230p8rsf	652	2	analyses	analysis	NNS
cord-269011-230p8rsf	652	3	revealed	reveal	VBD
cord-269011-230p8rsf	652	4	that	that	IN
cord-269011-230p8rsf	652	5	a	a	DT
cord-269011-230p8rsf	652	6	single	single	JJ
cord-269011-230p8rsf	652	7	second	second	JJ
cord-269011-230p8rsf	652	8	-	-	HYPH
cord-269011-230p8rsf	652	9	site	site	NN
cord-269011-230p8rsf	652	10	amino	amino	NN
cord-269011-230p8rsf	652	11	acid	acid	NN
cord-269011-230p8rsf	652	12	change	change	NN
cord-269011-230p8rsf	652	13	within	within	IN
cord-269011-230p8rsf	652	14	the	the	DT
cord-269011-230p8rsf	652	15	E	e	NN
cord-269011-230p8rsf	652	16	protein	protein	NN
cord-269011-230p8rsf	652	17	was	be	VBD
cord-269011-230p8rsf	652	18	able	able	JJ
cord-269011-230p8rsf	652	19	to	to	TO
cord-269011-230p8rsf	652	20	reverse	reverse	VB
cord-269011-230p8rsf	652	21	the	the	DT
cord-269011-230p8rsf	652	22	phenotypic	phenotypic	JJ
cord-269011-230p8rsf	652	23	effect	effect	NN
cord-269011-230p8rsf	652	24	of	of	IN
cord-269011-230p8rsf	652	25	the	the	DT
cord-269011-230p8rsf	652	26	original	original	JJ
cord-269011-230p8rsf	652	27	mutations	mutation	NNS
cord-269011-230p8rsf	652	28	,	,	,
cord-269011-230p8rsf	652	29	providing	provide	VBG
cord-269011-230p8rsf	652	30	support	support	NN
cord-269011-230p8rsf	652	31	for	for	IN
cord-269011-230p8rsf	652	32	possible	possible	JJ
cord-269011-230p8rsf	652	33	interactions	interaction	NNS
cord-269011-230p8rsf	652	34	between	between	IN
cord-269011-230p8rsf	652	35	E	e	NN
cord-269011-230p8rsf	652	36	protein	protein	NN
cord-269011-230p8rsf	652	37	monomers	monomer	NNS
cord-269011-230p8rsf	652	38	during	during	IN
cord-269011-230p8rsf	652	39	budding	bud	VBG
cord-269011-230p8rsf	652	40	(	(	-LRB-
cord-269011-230p8rsf	652	41	Fischer	Fischer	NNP
cord-269011-230p8rsf	652	42	et	et	NNP
cord-269011-230p8rsf	652	43	al	al	NNP
cord-269011-230p8rsf	652	44	.	.	NNP
cord-269011-230p8rsf	652	45	,	,	,
cord-269011-230p8rsf	652	46	1998	1998	CD
cord-269011-230p8rsf	652	47	)	)	-RRB-
cord-269011-230p8rsf	652	48	.	.	.
cord-269011-230p8rsf	653	1	Unexpectedly	unexpectedly	RB
cord-269011-230p8rsf	653	2	,	,	,
cord-269011-230p8rsf	653	3	complete	complete	JJ
cord-269011-230p8rsf	653	4	deletion	deletion	NN
cord-269011-230p8rsf	653	5	of	of	IN
cord-269011-230p8rsf	653	6	the	the	DT
cord-269011-230p8rsf	653	7	E	e	NN
cord-269011-230p8rsf	653	8	gene	gene	NN
cord-269011-230p8rsf	653	9	from	from	IN
cord-269011-230p8rsf	653	10	the	the	DT
cord-269011-230p8rsf	653	11	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	653	12	genome	genome	NN
cord-269011-230p8rsf	653	13	does	do	VBZ
cord-269011-230p8rsf	653	14	not	not	RB
cord-269011-230p8rsf	653	15	abolish	abolish	VB
cord-269011-230p8rsf	653	16	virion	virion	NN
cord-269011-230p8rsf	653	17	formation	formation	NN
cord-269011-230p8rsf	653	18	,	,	,
cord-269011-230p8rsf	653	19	demonstrating	demonstrate	VBG
cord-269011-230p8rsf	653	20	that	that	IN
cord-269011-230p8rsf	653	21	the	the	DT
cord-269011-230p8rsf	653	22	protein	protein	NN
cord-269011-230p8rsf	653	23	is	be	VBZ
cord-269011-230p8rsf	653	24	not	not	RB
cord-269011-230p8rsf	653	25	essential	essential	JJ
cord-269011-230p8rsf	653	26	for	for	IN
cord-269011-230p8rsf	653	27	budding	bud	VBG
cord-269011-230p8rsf	653	28	.	.	.
cord-269011-230p8rsf	654	1	Whereas	whereas	IN
cord-269011-230p8rsf	654	2	this	this	DT
cord-269011-230p8rsf	654	3	deletion	deletion	NN
cord-269011-230p8rsf	654	4	dramatically	dramatically	RB
cord-269011-230p8rsf	654	5	(	(	-LRB-
cord-269011-230p8rsf	654	6	at	at	IN
cord-269011-230p8rsf	654	7	least	least	JJS
cord-269011-230p8rsf	654	8	1000-fold	1000-fold	CD
cord-269011-230p8rsf	654	9	)	)	-RRB-
cord-269011-230p8rsf	654	10	reduced	reduce	VBD
cord-269011-230p8rsf	654	11	the	the	DT
cord-269011-230p8rsf	654	12	release	release	NN
cord-269011-230p8rsf	654	13	of	of	IN
cord-269011-230p8rsf	654	14	infectivity	infectivity	NN
cord-269011-230p8rsf	654	15	from	from	IN
cord-269011-230p8rsf	654	16	infected	infected	JJ
cord-269011-230p8rsf	654	17	cells	cell	NNS
cord-269011-230p8rsf	654	18	in	in	IN
cord-269011-230p8rsf	654	19	the	the	DT
cord-269011-230p8rsf	654	20	case	case	NN
cord-269011-230p8rsf	654	21	of	of	IN
cord-269011-230p8rsf	654	22	MHV	MHV	NNP
cord-269011-230p8rsf	654	23	-	-	HYPH
cord-269011-230p8rsf	654	24	A59	A59	NNP
cord-269011-230p8rsf	654	25	,	,	,
cord-269011-230p8rsf	654	26	knockout	knockout	NN
cord-269011-230p8rsf	654	27	of	of	IN
cord-269011-230p8rsf	654	28	the	the	DT
cord-269011-230p8rsf	654	29	TGEV	TGEV	NNP
cord-269011-230p8rsf	654	30	E	e	NN
cord-269011-230p8rsf	654	31	gene	gene	NN
cord-269011-230p8rsf	654	32	resulted	result	VBD
cord-269011-230p8rsf	654	33	in	in	IN
cord-269011-230p8rsf	654	34	a	a	DT
cord-269011-230p8rsf	654	35	lethal	lethal	JJ
cord-269011-230p8rsf	654	36	phenotype	phenotype	NN
cord-269011-230p8rsf	654	37	(	(	-LRB-
cord-269011-230p8rsf	654	38	Curtis	Curtis	NNP
cord-269011-230p8rsf	654	39	et	et	NNP
cord-269011-230p8rsf	654	40	al	al	NNP
cord-269011-230p8rsf	654	41	.	.	NNP
cord-269011-230p8rsf	654	42	,	,	,
cord-269011-230p8rsf	654	43	2002	2002	CD
cord-269011-230p8rsf	654	44	;	;	:
cord-269011-230p8rsf	654	45	Ortego	Ortego	NNP
cord-269011-230p8rsf	654	46	et	et	NNP
cord-269011-230p8rsf	654	47	al	al	NNP
cord-269011-230p8rsf	654	48	.	.	NNP
cord-269011-230p8rsf	654	49	,	,	,
cord-269011-230p8rsf	654	50	2002	2002	CD
cord-269011-230p8rsf	654	51	)	)	-RRB-
cord-269011-230p8rsf	654	52	.	.	.
cord-269011-230p8rsf	655	1	Remarkably	remarkably	RB
cord-269011-230p8rsf	655	2	,	,	,
cord-269011-230p8rsf	655	3	however	however	RB
cord-269011-230p8rsf	655	4	,	,	,
cord-269011-230p8rsf	655	5	in	in	IN
cord-269011-230p8rsf	655	6	the	the	DT
cord-269011-230p8rsf	655	7	latter	latter	JJ
cord-269011-230p8rsf	655	8	case	case	NN
cord-269011-230p8rsf	655	9	virions	virion	NNS
cord-269011-230p8rsf	655	10	still	still	RB
cord-269011-230p8rsf	655	11	assembled	assemble	VBN
cord-269011-230p8rsf	655	12	but	but	CC
cord-269011-230p8rsf	655	13	these	these	DT
cord-269011-230p8rsf	655	14	appeared	appear	VBD
cord-269011-230p8rsf	655	15	to	to	TO
cord-269011-230p8rsf	655	16	be	be	VB
cord-269011-230p8rsf	655	17	unable	unable	JJ
cord-269011-230p8rsf	655	18	to	to	TO
cord-269011-230p8rsf	655	19	leave	leave	VB
cord-269011-230p8rsf	655	20	the	the	DT
cord-269011-230p8rsf	655	21	cells	cell	NNS
cord-269011-230p8rsf	655	22	(	(	-LRB-
cord-269011-230p8rsf	655	23	J.	J.	NNP
cord-269011-230p8rsf	655	24	Ortego	Ortego	NNP
cord-269011-230p8rsf	655	25	and	and	CC
cord-269011-230p8rsf	655	26	L.	L.	NNP
cord-269011-230p8rsf	655	27	Enjuanes	Enjuanes	NNP
cord-269011-230p8rsf	655	28	,	,	,
cord-269011-230p8rsf	655	29	personal	personal	JJ
cord-269011-230p8rsf	655	30	communication	communication	NN
cord-269011-230p8rsf	655	31	)	)	-RRB-
cord-269011-230p8rsf	655	32	.	.	.
cord-269011-230p8rsf	656	1	The	the	DT
cord-269011-230p8rsf	656	2	VLP	VLP	NNP
cord-269011-230p8rsf	656	3	system	system	NN
cord-269011-230p8rsf	656	4	offers	offer	VBZ
cord-269011-230p8rsf	656	5	a	a	DT
cord-269011-230p8rsf	656	6	convenient	convenient	JJ
cord-269011-230p8rsf	656	7	assay	assay	NN
cord-269011-230p8rsf	656	8	to	to	TO
cord-269011-230p8rsf	656	9	study	study	VB
cord-269011-230p8rsf	656	10	many	many	JJ
cord-269011-230p8rsf	656	11	aspects	aspect	NNS
cord-269011-230p8rsf	656	12	of	of	IN
cord-269011-230p8rsf	656	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	656	14	envelope	envelope	NN
cord-269011-230p8rsf	656	15	assembly	assembly	NN
cord-269011-230p8rsf	656	16	.	.	.
cord-269011-230p8rsf	657	1	It	-PRON-	PRP
cord-269011-230p8rsf	657	2	was	be	VBD
cord-269011-230p8rsf	657	3	thus	thus	RB
cord-269011-230p8rsf	657	4	used	use	VBN
cord-269011-230p8rsf	657	5	to	to	TO
cord-269011-230p8rsf	657	6	analyze	analyze	VB
cord-269011-230p8rsf	657	7	the	the	DT
cord-269011-230p8rsf	657	8	primary	primary	JJ
cord-269011-230p8rsf	657	9	structure	structure	NN
cord-269011-230p8rsf	657	10	requirements	requirement	NNS
cord-269011-230p8rsf	657	11	of	of	IN
cord-269011-230p8rsf	657	12	the	the	DT
cord-269011-230p8rsf	657	13	M	M	NNP
cord-269011-230p8rsf	657	14	and	and	CC
cord-269011-230p8rsf	657	15	E	e	NN
cord-269011-230p8rsf	657	16	proteins	protein	NNS
cord-269011-230p8rsf	657	17	for	for	IN
cord-269011-230p8rsf	657	18	particle	particle	NN
cord-269011-230p8rsf	657	19	formation	formation	NN
cord-269011-230p8rsf	657	20	.	.	.
cord-269011-230p8rsf	658	1	For	for	IN
cord-269011-230p8rsf	658	2	the	the	DT
cord-269011-230p8rsf	658	3	M	M	NNP
cord-269011-230p8rsf	658	4	protein	protein	NN
cord-269011-230p8rsf	658	5	such	such	JJ
cord-269011-230p8rsf	658	6	studies	study	NNS
cord-269011-230p8rsf	658	7	demonstrated	demonstrate	VBD
cord-269011-230p8rsf	658	8	each	each	DT
cord-269011-230p8rsf	658	9	of	of	IN
cord-269011-230p8rsf	658	10	its	-PRON-	PRP$
cord-269011-230p8rsf	658	11	different	different	JJ
cord-269011-230p8rsf	658	12	domains	domain	NNS
cord-269011-230p8rsf	658	13	to	to	TO
cord-269011-230p8rsf	658	14	be	be	VB
cord-269011-230p8rsf	658	15	important	important	JJ
cord-269011-230p8rsf	658	16	.	.	.
cord-269011-230p8rsf	659	1	In	in	IN
cord-269011-230p8rsf	659	2	general	general	JJ
cord-269011-230p8rsf	659	3	,	,	,
cord-269011-230p8rsf	659	4	mutations	mutation	NNS
cord-269011-230p8rsf	659	5	(	(	-LRB-
cord-269011-230p8rsf	659	6	deletions	deletion	NNS
cord-269011-230p8rsf	659	7	,	,	,
cord-269011-230p8rsf	659	8	insertions	insertion	NNS
cord-269011-230p8rsf	659	9	,	,	,
cord-269011-230p8rsf	659	10	and	and	CC
cord-269011-230p8rsf	659	11	point	point	NN
cord-269011-230p8rsf	659	12	mutations	mutation	NNS
cord-269011-230p8rsf	659	13	)	)	-RRB-
cord-269011-230p8rsf	659	14	in	in	IN
cord-269011-230p8rsf	659	15	the	the	DT
cord-269011-230p8rsf	659	16	lumenal	lumenal	JJ
cord-269011-230p8rsf	659	17	domain	domain	NN
cord-269011-230p8rsf	659	18	,	,	,
cord-269011-230p8rsf	659	19	the	the	DT
cord-269011-230p8rsf	659	20	transmembrane	transmembrane	NN
cord-269011-230p8rsf	659	21	domains	domain	NNS
cord-269011-230p8rsf	659	22	,	,	,
cord-269011-230p8rsf	659	23	the	the	DT
cord-269011-230p8rsf	659	24	amphiphilic	amphiphilic	JJ
cord-269011-230p8rsf	659	25	domain	domain	NN
cord-269011-230p8rsf	659	26	,	,	,
cord-269011-230p8rsf	659	27	or	or	CC
cord-269011-230p8rsf	659	28	the	the	DT
cord-269011-230p8rsf	659	29	carboxy	carboxy	JJ
cord-269011-230p8rsf	659	30	-	-	HYPH
cord-269011-230p8rsf	659	31	terminal	terminal	NN
cord-269011-230p8rsf	659	32	domain	domain	NN
cord-269011-230p8rsf	659	33	of	of	IN
cord-269011-230p8rsf	659	34	the	the	DT
cord-269011-230p8rsf	659	35	MHV	MHV	NNP
cord-269011-230p8rsf	659	36	M	M	NNP
cord-269011-230p8rsf	659	37	protein	protein	NN
cord-269011-230p8rsf	659	38	strongly	strongly	RB
cord-269011-230p8rsf	659	39	affected	affect	VBD
cord-269011-230p8rsf	659	40	its	-PRON-	PRP$
cord-269011-230p8rsf	659	41	ability	ability	NN
cord-269011-230p8rsf	659	42	to	to	TO
cord-269011-230p8rsf	659	43	form	form	VB
cord-269011-230p8rsf	659	44	VLPs	vlp	NNS
cord-269011-230p8rsf	659	45	(	(	-LRB-
cord-269011-230p8rsf	659	46	de	de	FW
cord-269011-230p8rsf	659	47	Haan	Haan	NNP
cord-269011-230p8rsf	659	48	et	et	FW
cord-269011-230p8rsf	659	49	al	al	NNP
cord-269011-230p8rsf	659	50	.	.	NNP
cord-269011-230p8rsf	659	51	,	,	,
cord-269011-230p8rsf	659	52	1998a	1998a	CD
cord-269011-230p8rsf	659	53	)	)	-RRB-
cord-269011-230p8rsf	659	54	.	.	.
cord-269011-230p8rsf	660	1	The	the	DT
cord-269011-230p8rsf	660	2	assembly	assembly	NN
cord-269011-230p8rsf	660	3	process	process	NN
cord-269011-230p8rsf	660	4	was	be	VBD
cord-269011-230p8rsf	660	5	particularly	particularly	RB
cord-269011-230p8rsf	660	6	sensitive	sensitive	JJ
cord-269011-230p8rsf	660	7	to	to	IN
cord-269011-230p8rsf	660	8	changes	change	NNS
cord-269011-230p8rsf	660	9	in	in	IN
cord-269011-230p8rsf	660	10	the	the	DT
cord-269011-230p8rsf	660	11	carboxy	carboxy	JJ
cord-269011-230p8rsf	660	12	terminus	terminus	NN
cord-269011-230p8rsf	660	13	of	of	IN
cord-269011-230p8rsf	660	14	the	the	DT
cord-269011-230p8rsf	660	15	protein	protein	NN
cord-269011-230p8rsf	660	16	.	.	.
cord-269011-230p8rsf	661	1	Truncation	truncation	NN
cord-269011-230p8rsf	661	2	by	by	IN
cord-269011-230p8rsf	661	3	only	only	RB
cord-269011-230p8rsf	661	4	one	one	CD
cord-269011-230p8rsf	661	5	residue	residue	NN
cord-269011-230p8rsf	661	6	reduced	reduce	VBD
cord-269011-230p8rsf	661	7	the	the	DT
cord-269011-230p8rsf	661	8	efficiency	efficiency	NN
cord-269011-230p8rsf	661	9	severely	severely	RB
cord-269011-230p8rsf	661	10	whereas	whereas	IN
cord-269011-230p8rsf	661	11	removal	removal	NN
cord-269011-230p8rsf	661	12	of	of	IN
cord-269011-230p8rsf	661	13	two	two	CD
cord-269011-230p8rsf	661	14	residues	residue	NNS
cord-269011-230p8rsf	661	15	fully	fully	RB
cord-269011-230p8rsf	661	16	abolished	abolish	VBD
cord-269011-230p8rsf	661	17	particle	particle	NN
cord-269011-230p8rsf	661	18	formation	formation	NN
cord-269011-230p8rsf	661	19	.	.	.
cord-269011-230p8rsf	662	1	These	these	DT
cord-269011-230p8rsf	662	2	effects	effect	NNS
cord-269011-230p8rsf	662	3	appeared	appear	VBD
cord-269011-230p8rsf	662	4	to	to	TO
cord-269011-230p8rsf	662	5	be	be	VB
cord-269011-230p8rsf	662	6	less	less	RBR
cord-269011-230p8rsf	662	7	severe	severe	JJ
cord-269011-230p8rsf	662	8	in	in	IN
cord-269011-230p8rsf	662	9	the	the	DT
cord-269011-230p8rsf	662	10	context	context	NN
cord-269011-230p8rsf	662	11	of	of	IN
cord-269011-230p8rsf	662	12	a	a	DT
cord-269011-230p8rsf	662	13	normal	normal	JJ
cord-269011-230p8rsf	662	14	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	662	15	infection	infection	NN
cord-269011-230p8rsf	662	16	,	,	,
cord-269011-230p8rsf	662	17	probably	probably	RB
cord-269011-230p8rsf	662	18	because	because	IN
cord-269011-230p8rsf	662	19	additional	additional	JJ
cord-269011-230p8rsf	662	20	interactions	interaction	NNS
cord-269011-230p8rsf	662	21	can	can	MD
cord-269011-230p8rsf	662	22	compensate	compensate	VB
cord-269011-230p8rsf	662	23	.	.	.
cord-269011-230p8rsf	663	1	The	the	DT
cord-269011-230p8rsf	663	2	single	single	JJ
cord-269011-230p8rsf	663	3	-	-	HYPH
cord-269011-230p8rsf	663	4	residue	residue	NN
cord-269011-230p8rsf	663	5	deletion	deletion	NN
cord-269011-230p8rsf	663	6	,	,	,
cord-269011-230p8rsf	663	7	when	when	WRB
cord-269011-230p8rsf	663	8	introduced	introduce	VBN
cord-269011-230p8rsf	663	9	into	into	IN
cord-269011-230p8rsf	663	10	the	the	DT
cord-269011-230p8rsf	663	11	MHV	MHV	NNP
cord-269011-230p8rsf	663	12	genome	genome	NN
cord-269011-230p8rsf	663	13	,	,	,
cord-269011-230p8rsf	663	14	was	be	VBD
cord-269011-230p8rsf	663	15	without	without	IN
cord-269011-230p8rsf	663	16	measurable	measurable	JJ
cord-269011-230p8rsf	663	17	phenotype	phenotype	NN
cord-269011-230p8rsf	663	18	and	and	CC
cord-269011-230p8rsf	663	19	also	also	RB
cord-269011-230p8rsf	663	20	a	a	DT
cord-269011-230p8rsf	663	21	mutant	mutant	JJ
cord-269011-230p8rsf	663	22	virus	virus	NN
cord-269011-230p8rsf	663	23	with	with	IN
cord-269011-230p8rsf	663	24	a	a	DT
cord-269011-230p8rsf	663	25	truncation	truncation	NN
cord-269011-230p8rsf	663	26	of	of	IN
cord-269011-230p8rsf	663	27	two	two	CD
cord-269011-230p8rsf	663	28	residues	residue	NNS
cord-269011-230p8rsf	663	29	could	could	MD
cord-269011-230p8rsf	663	30	be	be	VB
cord-269011-230p8rsf	663	31	obtained	obtain	VBN
cord-269011-230p8rsf	663	32	,	,	,
cord-269011-230p8rsf	663	33	although	although	IN
cord-269011-230p8rsf	663	34	with	with	IN
cord-269011-230p8rsf	663	35	difficulty	difficulty	NN
cord-269011-230p8rsf	663	36	,	,	,
cord-269011-230p8rsf	663	37	as	as	IN
cord-269011-230p8rsf	663	38	it	-PRON-	PRP
cord-269011-230p8rsf	663	39	was	be	VBD
cord-269011-230p8rsf	663	40	severely	severely	RB
cord-269011-230p8rsf	663	41	affected	affect	VBN
cord-269011-230p8rsf	663	42	in	in	IN
cord-269011-230p8rsf	663	43	its	-PRON-	PRP$
cord-269011-230p8rsf	663	44	growth	growth	NN
cord-269011-230p8rsf	663	45	(	(	-LRB-
cord-269011-230p8rsf	663	46	de	de	FW
cord-269011-230p8rsf	663	47	Haan	Haan	NNP
cord-269011-230p8rsf	663	48	et	et	FW
cord-269011-230p8rsf	663	49	al	al	NNP
cord-269011-230p8rsf	663	50	.	.	NNP
cord-269011-230p8rsf	663	51	,	,	,
cord-269011-230p8rsf	663	52	1998a	1998a	CD
cord-269011-230p8rsf	663	53	;	;	:
cord-269011-230p8rsf	663	54	Kuo	Kuo	NNP
cord-269011-230p8rsf	663	55	and	and	CC
cord-269011-230p8rsf	663	56	Masters	Masters	NNPS
cord-269011-230p8rsf	663	57	,	,	,
cord-269011-230p8rsf	663	58	2002	2002	CD
cord-269011-230p8rsf	663	59	)	)	-RRB-
cord-269011-230p8rsf	663	60	.	.	.
cord-269011-230p8rsf	664	1	The	the	DT
cord-269011-230p8rsf	664	2	importance	importance	NN
cord-269011-230p8rsf	664	3	of	of	IN
cord-269011-230p8rsf	664	4	the	the	DT
cord-269011-230p8rsf	664	5	M	M	NNP
cord-269011-230p8rsf	664	6	protein	protein	NN
cord-269011-230p8rsf	664	7	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	664	8	and	and	CC
cord-269011-230p8rsf	664	9	transmembrane	transmembrane	NN
cord-269011-230p8rsf	664	10	domains	domain	NNS
cord-269011-230p8rsf	664	11	was	be	VBD
cord-269011-230p8rsf	664	12	confirmed	confirm	VBN
cord-269011-230p8rsf	664	13	by	by	IN
cord-269011-230p8rsf	664	14	VLP	VLP	NNP
cord-269011-230p8rsf	664	15	studies	study	NNS
cord-269011-230p8rsf	664	16	in	in	IN
cord-269011-230p8rsf	664	17	the	the	DT
cord-269011-230p8rsf	664	18	IBV	IBV	NNP
cord-269011-230p8rsf	664	19	system	system	NN
cord-269011-230p8rsf	664	20	;	;	,
cord-269011-230p8rsf	664	21	mutant	mutant	JJ
cord-269011-230p8rsf	664	22	proteins	protein	NNS
cord-269011-230p8rsf	664	23	lacking	lack	VBG
cord-269011-230p8rsf	664	24	portions	portion	NNS
cord-269011-230p8rsf	664	25	of	of	IN
cord-269011-230p8rsf	664	26	either	either	DT
cord-269011-230p8rsf	664	27	of	of	IN
cord-269011-230p8rsf	664	28	these	these	DT
cord-269011-230p8rsf	664	29	domains	domain	NNS
cord-269011-230p8rsf	664	30	were	be	VBD
cord-269011-230p8rsf	664	31	unable	unable	JJ
cord-269011-230p8rsf	664	32	to	to	TO
cord-269011-230p8rsf	664	33	support	support	VB
cord-269011-230p8rsf	664	34	particle	particle	NN
cord-269011-230p8rsf	664	35	assembly	assembly	NN
cord-269011-230p8rsf	664	36	(	(	-LRB-
cord-269011-230p8rsf	664	37	Corse	Corse	NNP
cord-269011-230p8rsf	664	38	and	and	CC
cord-269011-230p8rsf	664	39	Machamer	Machamer	NNP
cord-269011-230p8rsf	664	40	,	,	,
cord-269011-230p8rsf	664	41	2003	2003	CD
cord-269011-230p8rsf	664	42	)	)	-RRB-
cord-269011-230p8rsf	664	43	.	.	.
cord-269011-230p8rsf	665	1	Studies	study	NNS
cord-269011-230p8rsf	665	2	of	of	IN
cord-269011-230p8rsf	665	3	the	the	DT
cord-269011-230p8rsf	665	4	primary	primary	JJ
cord-269011-230p8rsf	665	5	structure	structure	NN
cord-269011-230p8rsf	665	6	requirements	requirement	NNS
cord-269011-230p8rsf	665	7	of	of	IN
cord-269011-230p8rsf	665	8	the	the	DT
cord-269011-230p8rsf	665	9	E	e	NN
cord-269011-230p8rsf	665	10	protein	protein	NN
cord-269011-230p8rsf	665	11	for	for	IN
cord-269011-230p8rsf	665	12	VLP	VLP	NNP
cord-269011-230p8rsf	665	13	formation	formation	NN
cord-269011-230p8rsf	665	14	revealed	reveal	VBD
cord-269011-230p8rsf	665	15	that	that	IN
cord-269011-230p8rsf	665	16	the	the	DT
cord-269011-230p8rsf	665	17	sequence	sequence	NN
cord-269011-230p8rsf	665	18	of	of	IN
cord-269011-230p8rsf	665	19	its	-PRON-	PRP$
cord-269011-230p8rsf	665	20	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	665	21	domain	domain	NN
cord-269011-230p8rsf	665	22	was	be	VBD
cord-269011-230p8rsf	665	23	not	not	RB
cord-269011-230p8rsf	665	24	critical	critical	JJ
cord-269011-230p8rsf	665	25	.	.	.
cord-269011-230p8rsf	666	1	The	the	DT
cord-269011-230p8rsf	666	2	assembly	assembly	NN
cord-269011-230p8rsf	666	3	capacity	capacity	NN
cord-269011-230p8rsf	666	4	of	of	IN
cord-269011-230p8rsf	666	5	the	the	DT
cord-269011-230p8rsf	666	6	protein	protein	NN
cord-269011-230p8rsf	666	7	was	be	VBD
cord-269011-230p8rsf	666	8	maintained	maintain	VBN
cord-269011-230p8rsf	666	9	when	when	WRB
cord-269011-230p8rsf	666	10	its	-PRON-	PRP$
cord-269011-230p8rsf	666	11	transmembrane	transmembrane	NN
cord-269011-230p8rsf	666	12	region	region	NN
cord-269011-230p8rsf	666	13	was	be	VBD
cord-269011-230p8rsf	666	14	partly	partly	RB
cord-269011-230p8rsf	666	15	or	or	CC
cord-269011-230p8rsf	666	16	completely	completely	RB
cord-269011-230p8rsf	666	17	replaced	replace	VBN
cord-269011-230p8rsf	666	18	by	by	IN
cord-269011-230p8rsf	666	19	the	the	DT
cord-269011-230p8rsf	666	20	corresponding	corresponding	JJ
cord-269011-230p8rsf	666	21	domain	domain	NN
cord-269011-230p8rsf	666	22	of	of	IN
cord-269011-230p8rsf	666	23	the	the	DT
cord-269011-230p8rsf	666	24	vesicular	vesicular	JJ
cord-269011-230p8rsf	666	25	stomatitis	stomatitis	NN
cord-269011-230p8rsf	666	26	virus	virus	NN
cord-269011-230p8rsf	666	27	(	(	-LRB-
cord-269011-230p8rsf	666	28	VSV	VSV	NNP
cord-269011-230p8rsf	666	29	)	)	-RRB-
cord-269011-230p8rsf	666	30	G	g	NN
cord-269011-230p8rsf	666	31	protein	protein	NN
cord-269011-230p8rsf	666	32	(	(	-LRB-
cord-269011-230p8rsf	666	33	Corse	Corse	NNP
cord-269011-230p8rsf	666	34	and	and	CC
cord-269011-230p8rsf	666	35	Machamer	Machamer	NNP
cord-269011-230p8rsf	666	36	,	,	,
cord-269011-230p8rsf	666	37	2003	2003	CD
cord-269011-230p8rsf	666	38	)	)	-RRB-
cord-269011-230p8rsf	666	39	.	.	.
cord-269011-230p8rsf	667	1	However	however	RB
cord-269011-230p8rsf	667	2	,	,	,
cord-269011-230p8rsf	667	3	when	when	WRB
cord-269011-230p8rsf	667	4	its	-PRON-	PRP$
cord-269011-230p8rsf	667	5	small	small	JJ
cord-269011-230p8rsf	667	6	aminoterminal	aminoterminal	JJ
cord-269011-230p8rsf	667	7	ectodomain	ectodomain	NN
cord-269011-230p8rsf	667	8	was	be	VBD
cord-269011-230p8rsf	667	9	additionally	additionally	RB
cord-269011-230p8rsf	667	10	replaced	replace	VBN
cord-269011-230p8rsf	667	11	by	by	IN
cord-269011-230p8rsf	667	12	the	the	DT
cord-269011-230p8rsf	667	13	large	large	JJ
cord-269011-230p8rsf	667	14	VSV	VSV	NNP
cord-269011-230p8rsf	667	15	G	G	NNP
cord-269011-230p8rsf	667	16	protein	protein	NN
cord-269011-230p8rsf	667	17	counterpart	counterpart	NN
cord-269011-230p8rsf	667	18	,	,	,
cord-269011-230p8rsf	667	19	the	the	DT
cord-269011-230p8rsf	667	20	chimeric	chimeric	JJ
cord-269011-230p8rsf	667	21	protein	protein	NN
cord-269011-230p8rsf	667	22	became	become	VBD
cord-269011-230p8rsf	667	23	nonfunctional	nonfunctional	JJ
cord-269011-230p8rsf	667	24	.	.	.
cord-269011-230p8rsf	668	1	Deletion	deletion	NN
cord-269011-230p8rsf	668	2	of	of	IN
cord-269011-230p8rsf	668	3	the	the	DT
cord-269011-230p8rsf	668	4	transmembrane	transmembrane	NN
cord-269011-230p8rsf	668	5	,	,	,
cord-269011-230p8rsf	668	6	but	but	CC
cord-269011-230p8rsf	668	7	not	not	RB
cord-269011-230p8rsf	668	8	the	the	DT
cord-269011-230p8rsf	668	9	amino	amino	NN
cord-269011-230p8rsf	668	10	-	-	HYPH
cord-269011-230p8rsf	668	11	terminal	terminal	NN
cord-269011-230p8rsf	668	12	,	,	,
cord-269011-230p8rsf	668	13	domain	domain	NN
cord-269011-230p8rsf	668	14	rendered	render	VBD
cord-269011-230p8rsf	668	15	the	the	DT
cord-269011-230p8rsf	668	16	E	e	NN
cord-269011-230p8rsf	668	17	protein	protein	NN
cord-269011-230p8rsf	668	18	essentially	essentially	RB
cord-269011-230p8rsf	668	19	assembly	assembly	VBZ
cord-269011-230p8rsf	668	20	incompetent	incompetent	JJ
cord-269011-230p8rsf	669	1	(	(	-LRB-
cord-269011-230p8rsf	669	2	Lim	Lim	NNP
cord-269011-230p8rsf	669	3	and	and	CC
cord-269011-230p8rsf	669	4	Liu	Liu	NNP
cord-269011-230p8rsf	669	5	,	,	,
cord-269011-230p8rsf	669	6	2001	2001	CD
cord-269011-230p8rsf	669	7	)	)	-RRB-
cord-269011-230p8rsf	669	8	.	.	.
cord-269011-230p8rsf	670	1	Deletions	deletion	NNS
cord-269011-230p8rsf	670	2	in	in	IN
cord-269011-230p8rsf	670	3	the	the	DT
cord-269011-230p8rsf	670	4	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	670	5	carboxy	carboxy	JJ
cord-269011-230p8rsf	670	6	-	-	HYPH
cord-269011-230p8rsf	670	7	terminal	terminal	NN
cord-269011-230p8rsf	670	8	half	half	NN
cord-269011-230p8rsf	670	9	of	of	IN
cord-269011-230p8rsf	670	10	the	the	DT
cord-269011-230p8rsf	670	11	E	e	NN
cord-269011-230p8rsf	670	12	protein	protein	NN
cord-269011-230p8rsf	670	13	mapped	map	VBD
cord-269011-230p8rsf	670	14	the	the	DT
cord-269011-230p8rsf	670	15	cysteine	cysteine	NN
cord-269011-230p8rsf	670	16	-	-	HYPH
cord-269011-230p8rsf	670	17	rich	rich	JJ
cord-269011-230p8rsf	670	18	region	region	NN
cord-269011-230p8rsf	670	19	as	as	IN
cord-269011-230p8rsf	670	20	the	the	DT
cord-269011-230p8rsf	670	21	most	most	RBS
cord-269011-230p8rsf	670	22	important	important	JJ
cord-269011-230p8rsf	670	23	part	part	NN
cord-269011-230p8rsf	670	24	for	for	IN
cord-269011-230p8rsf	670	25	VLP	VLP	NNP
cord-269011-230p8rsf	670	26	assembly	assembly	NN
cord-269011-230p8rsf	670	27	(	(	-LRB-
cord-269011-230p8rsf	670	28	Lim	Lim	NNP
cord-269011-230p8rsf	670	29	and	and	CC
cord-269011-230p8rsf	670	30	Liu	Liu	NNP
cord-269011-230p8rsf	670	31	,	,	,
cord-269011-230p8rsf	670	32	2001	2001	CD
cord-269011-230p8rsf	670	33	)	)	-RRB-
cord-269011-230p8rsf	670	34	.	.	.
cord-269011-230p8rsf	671	1	Although	although	IN
cord-269011-230p8rsf	671	2	the	the	DT
cord-269011-230p8rsf	671	3	interaction	interaction	NN
cord-269011-230p8rsf	671	4	between	between	IN
cord-269011-230p8rsf	671	5	M	M	NNP
cord-269011-230p8rsf	671	6	and	and	CC
cord-269011-230p8rsf	671	7	E	e	NN
cord-269011-230p8rsf	671	8	proteins	protein	NNS
cord-269011-230p8rsf	671	9	is	be	VBZ
cord-269011-230p8rsf	671	10	amply	amply	RB
cord-269011-230p8rsf	671	11	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	671	12	by	by	IN
cord-269011-230p8rsf	671	13	their	-PRON-	PRP$
cord-269011-230p8rsf	671	14	interdependence	interdependence	NN
cord-269011-230p8rsf	671	15	for	for	IN
cord-269011-230p8rsf	671	16	VLP	VLP	NNP
cord-269011-230p8rsf	671	17	formation	formation	NN
cord-269011-230p8rsf	671	18	,	,	,
cord-269011-230p8rsf	671	19	direct	direct	JJ
cord-269011-230p8rsf	671	20	evidence	evidence	NN
cord-269011-230p8rsf	671	21	for	for	IN
cord-269011-230p8rsf	671	22	their	-PRON-	PRP$
cord-269011-230p8rsf	671	23	interaction	interaction	NN
cord-269011-230p8rsf	671	24	has	have	VBZ
cord-269011-230p8rsf	671	25	actually	actually	RB
cord-269011-230p8rsf	671	26	been	be	VBN
cord-269011-230p8rsf	671	27	provided	provide	VBN
cord-269011-230p8rsf	671	28	only	only	RB
cord-269011-230p8rsf	671	29	for	for	IN
cord-269011-230p8rsf	671	30	the	the	DT
cord-269011-230p8rsf	671	31	IBV	IBV	NNP
cord-269011-230p8rsf	671	32	proteins	protein	NNS
cord-269011-230p8rsf	671	33	(	(	-LRB-
cord-269011-230p8rsf	671	34	Corse	Corse	NNP
cord-269011-230p8rsf	671	35	and	and	CC
cord-269011-230p8rsf	671	36	Machamer	Machamer	NNP
cord-269011-230p8rsf	671	37	,	,	,
cord-269011-230p8rsf	671	38	2003	2003	CD
cord-269011-230p8rsf	671	39	;	;	:
cord-269011-230p8rsf	672	1	Lim	Lim	NNP
cord-269011-230p8rsf	672	2	and	and	CC
cord-269011-230p8rsf	672	3	Liu	Liu	NNP
cord-269011-230p8rsf	672	4	,	,	,
cord-269011-230p8rsf	672	5	2001	2001	CD
cord-269011-230p8rsf	672	6	)	)	-RRB-
cord-269011-230p8rsf	672	7	.	.	.
cord-269011-230p8rsf	673	1	The	the	DT
cord-269011-230p8rsf	673	2	two	two	CD
cord-269011-230p8rsf	673	3	proteins	protein	NNS
cord-269011-230p8rsf	673	4	could	could	MD
cord-269011-230p8rsf	673	5	be	be	VB
cord-269011-230p8rsf	673	6	cross	cros	VBN
cord-269011-230p8rsf	673	7	-	-	VBN
cord-269011-230p8rsf	673	8	linked	link	VBN
cord-269011-230p8rsf	673	9	to	to	IN
cord-269011-230p8rsf	673	10	each	each	DT
cord-269011-230p8rsf	673	11	other	other	JJ
cord-269011-230p8rsf	673	12	in	in	IN
cord-269011-230p8rsf	673	13	IBV	IBV	NNP
cord-269011-230p8rsf	673	14	-	-	HYPH
cord-269011-230p8rsf	673	15	infected	infect	VBN
cord-269011-230p8rsf	673	16	cells	cell	NNS
cord-269011-230p8rsf	673	17	and	and	CC
cord-269011-230p8rsf	673	18	in	in	IN
cord-269011-230p8rsf	673	19	cells	cell	NNS
cord-269011-230p8rsf	673	20	coexpressing	coexpresse	VBG
cord-269011-230p8rsf	673	21	the	the	DT
cord-269011-230p8rsf	673	22	M	M	NNP
cord-269011-230p8rsf	673	23	and	and	CC
cord-269011-230p8rsf	673	24	E	e	NN
cord-269011-230p8rsf	673	25	genes	gene	NNS
cord-269011-230p8rsf	673	26	(	(	-LRB-
cord-269011-230p8rsf	673	27	Corse	Corse	NNP
cord-269011-230p8rsf	673	28	and	and	CC
cord-269011-230p8rsf	673	29	Machamer	Machamer	NNP
cord-269011-230p8rsf	673	30	,	,	,
cord-269011-230p8rsf	673	31	2003	2003	CD
cord-269011-230p8rsf	673	32	)	)	-RRB-
cord-269011-230p8rsf	673	33	.	.	.
cord-269011-230p8rsf	674	1	It	-PRON-	PRP
cord-269011-230p8rsf	674	2	appeared	appear	VBD
cord-269011-230p8rsf	674	3	that	that	IN
cord-269011-230p8rsf	674	4	the	the	DT
cord-269011-230p8rsf	674	5	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	674	6	tails	tail	NNS
cord-269011-230p8rsf	674	7	of	of	IN
cord-269011-230p8rsf	674	8	both	both	DT
cord-269011-230p8rsf	674	9	proteins	protein	NNS
cord-269011-230p8rsf	674	10	were	be	VBD
cord-269011-230p8rsf	674	11	required	require	VBN
cord-269011-230p8rsf	674	12	,	,	,
cord-269011-230p8rsf	674	13	suggesting	suggest	VBG
cord-269011-230p8rsf	674	14	they	-PRON-	PRP
cord-269011-230p8rsf	674	15	are	be	VBP
cord-269011-230p8rsf	674	16	involved	involve	VBN
cord-269011-230p8rsf	674	17	in	in	IN
cord-269011-230p8rsf	674	18	the	the	DT
cord-269011-230p8rsf	674	19	interaction	interaction	NN
cord-269011-230p8rsf	674	20	.	.	.
cord-269011-230p8rsf	675	1	In	in	IN
cord-269011-230p8rsf	675	2	another	another	DT
cord-269011-230p8rsf	675	3	study	study	NN
cord-269011-230p8rsf	675	4	M	M	NNP
cord-269011-230p8rsf	675	5	-	-	HYPH
cord-269011-230p8rsf	675	6	E	E	NNP
cord-269011-230p8rsf	675	7	interaction	interaction	NN
cord-269011-230p8rsf	675	8	was	be	VBD
cord-269011-230p8rsf	675	9	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	675	10	by	by	IN
cord-269011-230p8rsf	675	11	a	a	DT
cord-269011-230p8rsf	675	12	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	675	13	assay	assay	NN
cord-269011-230p8rsf	675	14	.	.	.
cord-269011-230p8rsf	676	1	Also	also	RB
cord-269011-230p8rsf	676	2	in	in	IN
cord-269011-230p8rsf	676	3	this	this	DT
cord-269011-230p8rsf	676	4	assay	assay	NN
cord-269011-230p8rsf	676	5	the	the	DT
cord-269011-230p8rsf	676	6	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	676	7	domain	domain	NN
cord-269011-230p8rsf	676	8	of	of	IN
cord-269011-230p8rsf	676	9	the	the	DT
cord-269011-230p8rsf	676	10	E	e	NN
cord-269011-230p8rsf	676	11	protein	protein	NN
cord-269011-230p8rsf	676	12	,	,	,
cord-269011-230p8rsf	676	13	comprising	comprise	VBG
cord-269011-230p8rsf	676	14	the	the	DT
cord-269011-230p8rsf	676	15	cysteine	cysteine	NN
cord-269011-230p8rsf	676	16	-	-	HYPH
cord-269011-230p8rsf	676	17	rich	rich	JJ
cord-269011-230p8rsf	676	18	region	region	NN
cord-269011-230p8rsf	676	19	,	,	,
cord-269011-230p8rsf	676	20	was	be	VBD
cord-269011-230p8rsf	676	21	found	find	VBN
cord-269011-230p8rsf	676	22	to	to	TO
cord-269011-230p8rsf	676	23	be	be	VB
cord-269011-230p8rsf	676	24	important	important	JJ
cord-269011-230p8rsf	676	25	as	as	IN
cord-269011-230p8rsf	676	26	its	-PRON-	PRP$
cord-269011-230p8rsf	676	27	deletion	deletion	NN
cord-269011-230p8rsf	676	28	affected	affect	VBD
cord-269011-230p8rsf	676	29	M	M	NNP
cord-269011-230p8rsf	676	30	-	-	HYPH
cord-269011-230p8rsf	676	31	E	e	NN
cord-269011-230p8rsf	676	32	interaction	interaction	NN
cord-269011-230p8rsf	676	33	to	to	IN
cord-269011-230p8rsf	676	34	the	the	DT
cord-269011-230p8rsf	676	35	greatest	great	JJS
cord-269011-230p8rsf	676	36	extent	extent	NN
cord-269011-230p8rsf	676	37	when	when	WRB
cord-269011-230p8rsf	676	38	compared	compare	VBN
cord-269011-230p8rsf	676	39	with	with	IN
cord-269011-230p8rsf	676	40	other	other	JJ
cord-269011-230p8rsf	676	41	deletion	deletion	NN
cord-269011-230p8rsf	676	42	mutant	mutant	NN
cord-269011-230p8rsf	676	43	E	e	NN
cord-269011-230p8rsf	676	44	proteins	protein	NNS
cord-269011-230p8rsf	676	45	(	(	-LRB-
cord-269011-230p8rsf	676	46	Lim	Lim	NNP
cord-269011-230p8rsf	676	47	and	and	CC
cord-269011-230p8rsf	676	48	Liu	Liu	NNP
cord-269011-230p8rsf	676	49	,	,	,
cord-269011-230p8rsf	676	50	2001	2001	CD
cord-269011-230p8rsf	676	51	)	)	-RRB-
cord-269011-230p8rsf	676	52	.	.	.
cord-269011-230p8rsf	677	1	The	the	DT
cord-269011-230p8rsf	677	2	results	result	NNS
cord-269011-230p8rsf	677	3	from	from	IN
cord-269011-230p8rsf	677	4	both	both	DT
cord-269011-230p8rsf	677	5	studies	study	NNS
cord-269011-230p8rsf	677	6	also	also	RB
cord-269011-230p8rsf	677	7	showed	show	VBD
cord-269011-230p8rsf	677	8	that	that	IN
cord-269011-230p8rsf	677	9	the	the	DT
cord-269011-230p8rsf	677	10	ability	ability	NN
cord-269011-230p8rsf	677	11	of	of	IN
cord-269011-230p8rsf	677	12	mutant	mutant	JJ
cord-269011-230p8rsf	677	13	E	e	NN
cord-269011-230p8rsf	677	14	or	or	CC
cord-269011-230p8rsf	677	15	M	M	NNP
cord-269011-230p8rsf	677	16	proteins	protein	NNS
cord-269011-230p8rsf	677	17	to	to	TO
cord-269011-230p8rsf	677	18	interact	interact	VB
cord-269011-230p8rsf	677	19	did	do	VBD
cord-269011-230p8rsf	677	20	not	not	RB
cord-269011-230p8rsf	677	21	correlate	correlate	VB
cord-269011-230p8rsf	677	22	with	with	IN
cord-269011-230p8rsf	677	23	their	-PRON-	PRP$
cord-269011-230p8rsf	677	24	assembly	assembly	NN
cord-269011-230p8rsf	677	25	competence	competence	NN
cord-269011-230p8rsf	677	26	.	.	.
cord-269011-230p8rsf	678	1	Apparently	apparently	RB
cord-269011-230p8rsf	678	2	,	,	,
cord-269011-230p8rsf	678	3	other	other	JJ
cord-269011-230p8rsf	678	4	requirements	requirement	NNS
cord-269011-230p8rsf	678	5	such	such	JJ
cord-269011-230p8rsf	678	6	as	as	IN
cord-269011-230p8rsf	678	7	homotypic	homotypic	NNP
cord-269011-230p8rsf	678	8	E	E	NNP
cord-269011-230p8rsf	678	9	or	or	CC
cord-269011-230p8rsf	678	10	M	M	NNP
cord-269011-230p8rsf	678	11	interactions	interaction	NNS
cord-269011-230p8rsf	678	12	or	or	CC
cord-269011-230p8rsf	678	13	interactions	interaction	NNS
cord-269011-230p8rsf	678	14	with	with	IN
cord-269011-230p8rsf	678	15	host	host	NN
cord-269011-230p8rsf	678	16	cell	cell	NN
cord-269011-230p8rsf	678	17	components	component	NNS
cord-269011-230p8rsf	678	18	must	must	MD
cord-269011-230p8rsf	678	19	be	be	VB
cord-269011-230p8rsf	678	20	met	meet	VBN
cord-269011-230p8rsf	678	21	.	.	.
cord-269011-230p8rsf	679	1	The	the	DT
cord-269011-230p8rsf	679	2	specificity	specificity	NN
cord-269011-230p8rsf	679	3	of	of	IN
cord-269011-230p8rsf	679	4	the	the	DT
cord-269011-230p8rsf	679	5	interaction	interaction	NN
cord-269011-230p8rsf	679	6	between	between	IN
cord-269011-230p8rsf	679	7	the	the	DT
cord-269011-230p8rsf	679	8	M	M	NNP
cord-269011-230p8rsf	679	9	and	and	CC
cord-269011-230p8rsf	679	10	E	e	NN
cord-269011-230p8rsf	679	11	proteins	protein	NNS
cord-269011-230p8rsf	679	12	during	during	IN
cord-269011-230p8rsf	679	13	particle	particle	NN
cord-269011-230p8rsf	679	14	assembly	assembly	NN
cord-269011-230p8rsf	679	15	was	be	VBD
cord-269011-230p8rsf	679	16	further	further	RB
cord-269011-230p8rsf	679	17	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	679	18	by	by	IN
cord-269011-230p8rsf	679	19	the	the	DT
cord-269011-230p8rsf	679	20	poorly	poorly	RB
cord-269011-230p8rsf	679	21	successful	successful	JJ
cord-269011-230p8rsf	679	22	attempts	attempt	NNS
cord-269011-230p8rsf	679	23	to	to	TO
cord-269011-230p8rsf	679	24	generate	generate	VB
cord-269011-230p8rsf	679	25	chimeric	chimeric	JJ
cord-269011-230p8rsf	679	26	VLPs	vlp	NNS
cord-269011-230p8rsf	679	27	.	.	.
cord-269011-230p8rsf	680	1	No	no	DT
cord-269011-230p8rsf	680	2	particles	particle	NNS
cord-269011-230p8rsf	680	3	were	be	VBD
cord-269011-230p8rsf	680	4	observed	observe	VBN
cord-269011-230p8rsf	680	5	when	when	WRB
cord-269011-230p8rsf	680	6	heterologous	heterologous	JJ
cord-269011-230p8rsf	680	7	combinations	combination	NNS
cord-269011-230p8rsf	680	8	of	of	IN
cord-269011-230p8rsf	680	9	TGEV	TGEV	NNP
cord-269011-230p8rsf	680	10	and	and	CC
cord-269011-230p8rsf	680	11	BCoV	BCoV	NNP
cord-269011-230p8rsf	680	12	M	M	NNP
cord-269011-230p8rsf	680	13	and	and	CC
cord-269011-230p8rsf	680	14	E	e	NN
cord-269011-230p8rsf	680	15	proteins	protein	NNS
cord-269011-230p8rsf	680	16	were	be	VBD
cord-269011-230p8rsf	680	17	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	681	1	(	(	-LRB-
cord-269011-230p8rsf	681	2	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	681	3	et	et	NNP
cord-269011-230p8rsf	681	4	al	al	NNP
cord-269011-230p8rsf	681	5	.	.	NNP
cord-269011-230p8rsf	681	6	,	,	,
cord-269011-230p8rsf	681	7	1998b	1998b	CD
cord-269011-230p8rsf	681	8	)	)	-RRB-
cord-269011-230p8rsf	681	9	and	and	CC
cord-269011-230p8rsf	681	10	the	the	DT
cord-269011-230p8rsf	681	11	same	same	JJ
cord-269011-230p8rsf	681	12	was	be	VBD
cord-269011-230p8rsf	681	13	true	true	JJ
cord-269011-230p8rsf	681	14	for	for	IN
cord-269011-230p8rsf	681	15	heterologous	heterologous	JJ
cord-269011-230p8rsf	681	16	combinations	combination	NNS
cord-269011-230p8rsf	681	17	of	of	IN
cord-269011-230p8rsf	681	18	FIPV	FIPV	NNS
cord-269011-230p8rsf	681	19	and	and	CC
cord-269011-230p8rsf	681	20	MHV	MHV	NNP
cord-269011-230p8rsf	681	21	M	M	NNP
cord-269011-230p8rsf	681	22	and	and	CC
cord-269011-230p8rsf	681	23	E	e	NN
cord-269011-230p8rsf	681	24	proteins	protein	NNS
cord-269011-230p8rsf	681	25	(	(	-LRB-
cord-269011-230p8rsf	681	26	H.	H.	NNP
cord-269011-230p8rsf	681	27	Vennema	Vennema	NNP
cord-269011-230p8rsf	681	28	and	and	CC
cord-269011-230p8rsf	681	29	P.	P.	NNP
cord-269011-230p8rsf	681	30	J.	J.	NNP
cord-269011-230p8rsf	681	31	M.	M.	NNP
cord-269011-230p8rsf	681	32	Rottier	Rottier	NNP
cord-269011-230p8rsf	681	33	,	,	,
cord-269011-230p8rsf	681	34	unpublished	unpublished	JJ
cord-269011-230p8rsf	681	35	results	result	NNS
cord-269011-230p8rsf	681	36	)	)	-RRB-
cord-269011-230p8rsf	681	37	.	.	.
cord-269011-230p8rsf	682	1	In	in	IN
cord-269011-230p8rsf	682	2	both	both	DT
cord-269011-230p8rsf	682	3	studies	study	NNS
cord-269011-230p8rsf	682	4	chimeric	chimeric	JJ
cord-269011-230p8rsf	682	5	M	M	NNP
cord-269011-230p8rsf	682	6	and	and	CC
cord-269011-230p8rsf	682	7	E	e	NN
cord-269011-230p8rsf	682	8	proteins	protein	NNS
cord-269011-230p8rsf	682	9	were	be	VBD
cord-269011-230p8rsf	682	10	also	also	RB
cord-269011-230p8rsf	682	11	tested	test	VBN
cord-269011-230p8rsf	682	12	,	,	,
cord-269011-230p8rsf	682	13	demonstrating	demonstrate	VBG
cord-269011-230p8rsf	682	14	that	that	IN
cord-269011-230p8rsf	682	15	,	,	,
cord-269011-230p8rsf	682	16	except	except	IN
cord-269011-230p8rsf	682	17	in	in	IN
cord-269011-230p8rsf	682	18	one	one	CD
cord-269011-230p8rsf	682	19	case	case	NN
cord-269011-230p8rsf	682	20	,	,	,
cord-269011-230p8rsf	682	21	exchanges	exchange	NNS
cord-269011-230p8rsf	682	22	between	between	IN
cord-269011-230p8rsf	682	23	corresponding	correspond	VBG
cord-269011-230p8rsf	682	24	domains	domain	NNS
cord-269011-230p8rsf	682	25	rendered	render	VBD
cord-269011-230p8rsf	682	26	the	the	DT
cord-269011-230p8rsf	682	27	proteins	protein	NNS
cord-269011-230p8rsf	682	28	assembly	assembly	NN
cord-269011-230p8rsf	682	29	incompetent	incompetent	JJ
cord-269011-230p8rsf	682	30	.	.	.
cord-269011-230p8rsf	683	1	Only	only	RB
cord-269011-230p8rsf	683	2	when	when	WRB
cord-269011-230p8rsf	683	3	the	the	DT
cord-269011-230p8rsf	683	4	TGEV	TGEV	NNP
cord-269011-230p8rsf	683	5	M	M	NNP
cord-269011-230p8rsf	683	6	protein	protein	NN
cord-269011-230p8rsf	683	7	amino	amino	NNS
cord-269011-230p8rsf	683	8	-	-	HYPH
cord-269011-230p8rsf	683	9	terminal	terminal	NN
cord-269011-230p8rsf	683	10	ectodomain	ectodomain	NN
cord-269011-230p8rsf	683	11	was	be	VBD
cord-269011-230p8rsf	683	12	replaced	replace	VBN
cord-269011-230p8rsf	683	13	with	with	IN
cord-269011-230p8rsf	683	14	that	that	DT
cord-269011-230p8rsf	683	15	of	of	IN
cord-269011-230p8rsf	683	16	BCoV	BCoV	NNP
cord-269011-230p8rsf	683	17	did	do	VBD
cord-269011-230p8rsf	683	18	the	the	DT
cord-269011-230p8rsf	683	19	chimeric	chimeric	JJ
cord-269011-230p8rsf	683	20	polypeptide	polypeptide	NN
cord-269011-230p8rsf	683	21	support	support	NN
cord-269011-230p8rsf	683	22	VLP	VLP	NNP
cord-269011-230p8rsf	683	23	formation	formation	NN
cord-269011-230p8rsf	683	24	in	in	IN
cord-269011-230p8rsf	683	25	combination	combination	NN
cord-269011-230p8rsf	683	26	with	with	IN
cord-269011-230p8rsf	683	27	the	the	DT
cord-269011-230p8rsf	683	28	TGEV	TGEV	NNP
cord-269011-230p8rsf	683	29	E	e	NN
cord-269011-230p8rsf	683	30	protein	protein	NN
cord-269011-230p8rsf	683	31	;	;	:
cord-269011-230p8rsf	683	32	VLP	VLP	NNP
cord-269011-230p8rsf	683	33	formations	formation	NNS
cord-269011-230p8rsf	683	34	was	be	VBD
cord-269011-230p8rsf	683	35	also	also	RB
cord-269011-230p8rsf	683	36	supported	support	VBN
cord-269011-230p8rsf	683	37	,	,	,
cord-269011-230p8rsf	683	38	but	but	CC
cord-269011-230p8rsf	683	39	to	to	IN
cord-269011-230p8rsf	683	40	different	different	JJ
cord-269011-230p8rsf	683	41	extents	extent	NNS
cord-269011-230p8rsf	683	42	,	,	,
cord-269011-230p8rsf	683	43	with	with	IN
cord-269011-230p8rsf	683	44	TGEV	TGEV	NNP
cord-269011-230p8rsf	683	45	/	/	SYM
cord-269011-230p8rsf	683	46	BCoV	BCoV	NNP
cord-269011-230p8rsf	683	47	chimeric	chimeric	JJ
cord-269011-230p8rsf	683	48	E	e	NN
cord-269011-230p8rsf	683	49	proteins	protein	NNS
cord-269011-230p8rsf	683	50	and	and	CC
cord-269011-230p8rsf	683	51	-	-	HYPH
cord-269011-230p8rsf	683	52	poorly	poorly	RB
cord-269011-230p8rsf	683	53	,	,	,
cord-269011-230p8rsf	683	54	however	however	RB
cord-269011-230p8rsf	683	55	-	-	:
cord-269011-230p8rsf	683	56	with	with	IN
cord-269011-230p8rsf	683	57	the	the	DT
cord-269011-230p8rsf	683	58	BCoV	BCoV	NNP
cord-269011-230p8rsf	683	59	E	e	NN
cord-269011-230p8rsf	683	60	protein	protein	NN
cord-269011-230p8rsf	683	61	(	(	-LRB-
cord-269011-230p8rsf	683	62	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	683	63	et	et	NNP
cord-269011-230p8rsf	683	64	al	al	NNP
cord-269011-230p8rsf	683	65	.	.	NNP
cord-269011-230p8rsf	683	66	,	,	,
cord-269011-230p8rsf	683	67	1998b	1998b	CD
cord-269011-230p8rsf	683	68	)	)	-RRB-
cord-269011-230p8rsf	683	69	.	.	.
cord-269011-230p8rsf	684	1	The	the	DT
cord-269011-230p8rsf	684	2	reciprocal	reciprocal	JJ
cord-269011-230p8rsf	684	3	M	M	NNP
cord-269011-230p8rsf	684	4	construct	construct	NN
cord-269011-230p8rsf	684	5	,	,	,
cord-269011-230p8rsf	684	6	the	the	DT
cord-269011-230p8rsf	684	7	BCoV	BCoV	NNP
cord-269011-230p8rsf	684	8	M	M	NNP
cord-269011-230p8rsf	684	9	protein	protein	NN
cord-269011-230p8rsf	684	10	carrying	carry	VBG
cord-269011-230p8rsf	684	11	the	the	DT
cord-269011-230p8rsf	684	12	TGEV	TGEV	NNP
cord-269011-230p8rsf	684	13	ectodomain	ectodomain	NN
cord-269011-230p8rsf	684	14	,	,	,
cord-269011-230p8rsf	684	15	was	be	VBD
cord-269011-230p8rsf	684	16	nonfunctional	nonfunctional	JJ
cord-269011-230p8rsf	684	17	,	,	,
cord-269011-230p8rsf	684	18	even	even	RB
cord-269011-230p8rsf	684	19	in	in	IN
cord-269011-230p8rsf	684	20	combination	combination	NN
cord-269011-230p8rsf	684	21	with	with	IN
cord-269011-230p8rsf	684	22	TGEV	TGEV	NNP
cord-269011-230p8rsf	684	23	E	e	NN
cord-269011-230p8rsf	684	24	protein	protein	NN
cord-269011-230p8rsf	684	25	.	.	.
cord-269011-230p8rsf	685	1	Consistently	consistently	RB
cord-269011-230p8rsf	685	2	,	,	,
cord-269011-230p8rsf	685	3	replacement	replacement	NN
cord-269011-230p8rsf	685	4	of	of	IN
cord-269011-230p8rsf	685	5	the	the	DT
cord-269011-230p8rsf	685	6	ectodomain	ectodomain	NN
cord-269011-230p8rsf	685	7	with	with	IN
cord-269011-230p8rsf	685	8	that	that	DT
cord-269011-230p8rsf	685	9	of	of	IN
cord-269011-230p8rsf	685	10	FIPV	FIPV	NNP
cord-269011-230p8rsf	685	11	M	M	NNP
cord-269011-230p8rsf	685	12	also	also	RB
cord-269011-230p8rsf	685	13	abolished	abolish	VBD
cord-269011-230p8rsf	685	14	the	the	DT
cord-269011-230p8rsf	685	15	productive	productive	JJ
cord-269011-230p8rsf	685	16	partnership	partnership	NN
cord-269011-230p8rsf	685	17	of	of	IN
cord-269011-230p8rsf	685	18	MHV	MHV	NNP
cord-269011-230p8rsf	685	19	M	M	NNP
cord-269011-230p8rsf	685	20	protein	protein	NN
cord-269011-230p8rsf	685	21	with	with	IN
cord-269011-230p8rsf	685	22	MHV	MHV	NNP
cord-269011-230p8rsf	685	23	E	E	NNP
cord-269011-230p8rsf	685	24	(	(	-LRB-
cord-269011-230p8rsf	685	25	de	de	FW
cord-269011-230p8rsf	685	26	Haan	Haan	NNP
cord-269011-230p8rsf	685	27	et	et	FW
cord-269011-230p8rsf	685	28	al	al	NNP
cord-269011-230p8rsf	685	29	.	.	NNP
cord-269011-230p8rsf	685	30	,	,	,
cord-269011-230p8rsf	685	31	1999	1999	CD
cord-269011-230p8rsf	685	32	)	)	-RRB-
cord-269011-230p8rsf	685	33	.	.	.
cord-269011-230p8rsf	686	1	As	as	IN
cord-269011-230p8rsf	686	2	the	the	DT
cord-269011-230p8rsf	686	3	disproportionate	disproportionate	JJ
cord-269011-230p8rsf	686	4	amounts	amount	NNS
cord-269011-230p8rsf	686	5	of	of	IN
cord-269011-230p8rsf	686	6	M	m	NN
cord-269011-230p8rsf	686	7	and	and	CC
cord-269011-230p8rsf	686	8	E	e	NN
cord-269011-230p8rsf	686	9	proteins	protein	NNS
cord-269011-230p8rsf	686	10	in	in	IN
cord-269011-230p8rsf	686	11	VLPs	vlp	NNS
cord-269011-230p8rsf	686	12	already	already	RB
cord-269011-230p8rsf	686	13	imply	imply	VBP
cord-269011-230p8rsf	686	14	,	,	,
cord-269011-230p8rsf	686	15	homotypic	homotypic	JJ
cord-269011-230p8rsf	686	16	interactions	interaction	NNS
cord-269011-230p8rsf	686	17	between	between	IN
cord-269011-230p8rsf	686	18	M	M	NNP
cord-269011-230p8rsf	686	19	molecules	molecule	NNS
cord-269011-230p8rsf	686	20	must	must	MD
cord-269011-230p8rsf	686	21	constitute	constitute	VB
cord-269011-230p8rsf	686	22	the	the	DT
cord-269011-230p8rsf	686	23	energetic	energetic	JJ
cord-269011-230p8rsf	686	24	basis	basis	NN
cord-269011-230p8rsf	686	25	underlying	underlie	VBG
cord-269011-230p8rsf	686	26	the	the	DT
cord-269011-230p8rsf	686	27	formation	formation	NN
cord-269011-230p8rsf	686	28	of	of	IN
cord-269011-230p8rsf	686	29	the	the	DT
cord-269011-230p8rsf	686	30	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	686	31	envelope	envelope	NN
cord-269011-230p8rsf	686	32	.	.	.
cord-269011-230p8rsf	687	1	In	in	IN
cord-269011-230p8rsf	687	2	MHV	MHV	NNP
cord-269011-230p8rsf	687	3	-	-	HYPH
cord-269011-230p8rsf	687	4	based	base	VBN
cord-269011-230p8rsf	687	5	VLPs	vlp	NNS
cord-269011-230p8rsf	687	6	generated	generate	VBN
cord-269011-230p8rsf	687	7	by	by	IN
cord-269011-230p8rsf	687	8	coexpression	coexpression	NN
cord-269011-230p8rsf	687	9	of	of	IN
cord-269011-230p8rsf	687	10	M	M	NNP
cord-269011-230p8rsf	687	11	and	and	CC
cord-269011-230p8rsf	687	12	E	e	NN
cord-269011-230p8rsf	687	13	proteins	protein	NNS
cord-269011-230p8rsf	687	14	,	,	,
cord-269011-230p8rsf	687	15	for	for	IN
cord-269011-230p8rsf	687	16	instance	instance	NN
cord-269011-230p8rsf	687	17	,	,	,
cord-269011-230p8rsf	687	18	the	the	DT
cord-269011-230p8rsf	687	19	sheer	sheer	JJ
cord-269011-230p8rsf	687	20	excess	excess	NN
cord-269011-230p8rsf	687	21	of	of	IN
cord-269011-230p8rsf	687	22	M	M	NNP
cord-269011-230p8rsf	687	23	protein	protein	NN
cord-269011-230p8rsf	687	24	-	-	:
cord-269011-230p8rsf	687	25	the	the	DT
cord-269011-230p8rsf	687	26	relative	relative	JJ
cord-269011-230p8rsf	687	27	molar	molar	JJ
cord-269011-230p8rsf	687	28	presence	presence	NN
cord-269011-230p8rsf	687	29	of	of	IN
cord-269011-230p8rsf	687	30	E	e	NN
cord-269011-230p8rsf	687	31	in	in	IN
cord-269011-230p8rsf	687	32	the	the	DT
cord-269011-230p8rsf	687	33	particles	particle	NNS
cord-269011-230p8rsf	687	34	is	be	VBZ
cord-269011-230p8rsf	687	35	less	less	JJR
cord-269011-230p8rsf	687	36	than	than	IN
cord-269011-230p8rsf	687	37	1%-is	1%-is	CD
cord-269011-230p8rsf	687	38	evidence	evidence	NN
cord-269011-230p8rsf	687	39	for	for	IN
cord-269011-230p8rsf	687	40	the	the	DT
cord-269011-230p8rsf	687	41	strong	strong	JJ
cord-269011-230p8rsf	687	42	interactive	interactive	JJ
cord-269011-230p8rsf	687	43	forces	force	NNS
cord-269011-230p8rsf	687	44	between	between	IN
cord-269011-230p8rsf	687	45	M	M	NNP
cord-269011-230p8rsf	687	46	molecules	molecule	NNS
cord-269011-230p8rsf	687	47	.	.	.
cord-269011-230p8rsf	688	1	Hence	hence	RB
cord-269011-230p8rsf	688	2	,	,	,
cord-269011-230p8rsf	688	3	envelope	envelope	NN
cord-269011-230p8rsf	688	4	assembly	assembly	NN
cord-269011-230p8rsf	688	5	is	be	VBZ
cord-269011-230p8rsf	688	6	thought	think	VBN
cord-269011-230p8rsf	688	7	to	to	TO
cord-269011-230p8rsf	688	8	be	be	VB
cord-269011-230p8rsf	688	9	driven	drive	VBN
cord-269011-230p8rsf	688	10	primarily	primarily	RB
cord-269011-230p8rsf	688	11	by	by	IN
cord-269011-230p8rsf	688	12	laterally	laterally	RB
cord-269011-230p8rsf	688	13	interacting	interact	VBG
cord-269011-230p8rsf	688	14	M	m	NN
cord-269011-230p8rsf	688	15	molecules	molecule	NNS
cord-269011-230p8rsf	688	16	that	that	WDT
cord-269011-230p8rsf	688	17	form	form	VBP
cord-269011-230p8rsf	688	18	a	a	DT
cord-269011-230p8rsf	688	19	two	two	CD
cord-269011-230p8rsf	688	20	-	-	HYPH
cord-269011-230p8rsf	688	21	dimensional	dimensional	JJ
cord-269011-230p8rsf	688	22	lattice	lattice	NN
cord-269011-230p8rsf	688	23	in	in	IN
cord-269011-230p8rsf	688	24	intracellular	intracellular	JJ
cord-269011-230p8rsf	688	25	membranes	membrane	NNS
cord-269011-230p8rsf	688	26	(	(	-LRB-
cord-269011-230p8rsf	688	27	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	688	28	et	et	NNP
cord-269011-230p8rsf	688	29	al	al	NNP
cord-269011-230p8rsf	688	30	.	.	NNP
cord-269011-230p8rsf	688	31	,	,	,
cord-269011-230p8rsf	688	32	1993b	1993b	CD
cord-269011-230p8rsf	688	33	.	.	.
cord-269011-230p8rsf	689	1	Large	large	JJ
cord-269011-230p8rsf	689	2	multimeric	multimeric	JJ
cord-269011-230p8rsf	689	3	complexes	complex	NNS
cord-269011-230p8rsf	689	4	of	of	IN
cord-269011-230p8rsf	689	5	M	M	NNP
cord-269011-230p8rsf	689	6	protein	protein	NN
cord-269011-230p8rsf	689	7	have	have	VBP
cord-269011-230p8rsf	689	8	indeed	indeed	RB
cord-269011-230p8rsf	689	9	been	be	VBN
cord-269011-230p8rsf	689	10	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	689	11	biochemically	biochemically	RB
cord-269011-230p8rsf	689	12	after	after	IN
cord-269011-230p8rsf	689	13	individual	individual	JJ
cord-269011-230p8rsf	689	14	expression	expression	NN
cord-269011-230p8rsf	689	15	of	of	IN
cord-269011-230p8rsf	689	16	the	the	DT
cord-269011-230p8rsf	689	17	MHV	MHV	NNP
cord-269011-230p8rsf	689	18	protein	protein	NN
cord-269011-230p8rsf	689	19	in	in	IN
cord-269011-230p8rsf	689	20	cells	cell	NNS
cord-269011-230p8rsf	689	21	.	.	.
cord-269011-230p8rsf	690	1	When	when	WRB
cord-269011-230p8rsf	690	2	the	the	DT
cord-269011-230p8rsf	690	3	association	association	NN
cord-269011-230p8rsf	690	4	of	of	IN
cord-269011-230p8rsf	690	5	the	the	DT
cord-269011-230p8rsf	690	6	M	M	NNP
cord-269011-230p8rsf	690	7	molecules	molecule	NNS
cord-269011-230p8rsf	690	8	was	be	VBD
cord-269011-230p8rsf	690	9	maintained	maintain	VBN
cord-269011-230p8rsf	690	10	by	by	IN
cord-269011-230p8rsf	690	11	the	the	DT
cord-269011-230p8rsf	690	12	careful	careful	JJ
cord-269011-230p8rsf	690	13	selection	selection	NN
cord-269011-230p8rsf	690	14	of	of	IN
cord-269011-230p8rsf	690	15	cell	cell	NN
cord-269011-230p8rsf	690	16	lysis	lysis	NN
cord-269011-230p8rsf	690	17	conditions	condition	NNS
cord-269011-230p8rsf	690	18	,	,	,
cord-269011-230p8rsf	690	19	sucrose	sucrose	NN
cord-269011-230p8rsf	690	20	gradient	gradient	NN
cord-269011-230p8rsf	690	21	analysis	analysis	NN
cord-269011-230p8rsf	690	22	revealed	reveal	VBD
cord-269011-230p8rsf	690	23	the	the	DT
cord-269011-230p8rsf	690	24	existence	existence	NN
cord-269011-230p8rsf	690	25	of	of	IN
cord-269011-230p8rsf	690	26	large	large	JJ
cord-269011-230p8rsf	690	27	heterogeneous	heterogeneous	JJ
cord-269011-230p8rsf	690	28	(	(	-LRB-
cord-269011-230p8rsf	690	29	up	up	IN
cord-269011-230p8rsf	690	30	to	to	IN
cord-269011-230p8rsf	690	31	about	about	RB
cord-269011-230p8rsf	690	32	40	40	CD
cord-269011-230p8rsf	690	33	molecules	molecule	NNS
cord-269011-230p8rsf	690	34	)	)	-RRB-
cord-269011-230p8rsf	690	35	complexes	complex	NNS
cord-269011-230p8rsf	690	36	,	,	,
cord-269011-230p8rsf	690	37	which	which	WDT
cord-269011-230p8rsf	690	38	accumulated	accumulate	VBD
cord-269011-230p8rsf	690	39	in	in	IN
cord-269011-230p8rsf	690	40	the	the	DT
cord-269011-230p8rsf	690	41	Golgi	Golgi	NNP
cord-269011-230p8rsf	690	42	compartment	compartment	NN
cord-269011-230p8rsf	691	1	(	(	-LRB-
cord-269011-230p8rsf	691	2	Locker	Locker	NNP
cord-269011-230p8rsf	691	3	et	et	NNP
cord-269011-230p8rsf	691	4	al	al	NNP
cord-269011-230p8rsf	691	5	.	.	NNP
cord-269011-230p8rsf	691	6	,	,	,
cord-269011-230p8rsf	691	7	1995	1995	CD
cord-269011-230p8rsf	691	8	)	)	-RRB-
cord-269011-230p8rsf	691	9	.	.	.
cord-269011-230p8rsf	692	1	Somewhat	somewhat	RB
cord-269011-230p8rsf	692	2	smaller	small	JJR
cord-269011-230p8rsf	692	3	complexes	complex	NNS
cord-269011-230p8rsf	692	4	were	be	VBD
cord-269011-230p8rsf	692	5	obtained	obtain	VBN
cord-269011-230p8rsf	692	6	when	when	WRB
cord-269011-230p8rsf	692	7	the	the	DT
cord-269011-230p8rsf	692	8	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	692	9	tail	tail	NN
cord-269011-230p8rsf	692	10	of	of	IN
cord-269011-230p8rsf	692	11	the	the	DT
cord-269011-230p8rsf	692	12	protein	protein	NN
cord-269011-230p8rsf	692	13	was	be	VBD
cord-269011-230p8rsf	692	14	removed	remove	VBN
cord-269011-230p8rsf	692	15	;	;	:
cord-269011-230p8rsf	692	16	these	these	DT
cord-269011-230p8rsf	692	17	complexes	complex	NNS
cord-269011-230p8rsf	692	18	were	be	VBD
cord-269011-230p8rsf	692	19	no	no	RB
cord-269011-230p8rsf	692	20	longer	long	RBR
cord-269011-230p8rsf	692	21	retained	retain	VBN
cord-269011-230p8rsf	692	22	in	in	IN
cord-269011-230p8rsf	692	23	the	the	DT
cord-269011-230p8rsf	692	24	Golgi	Golgi	NNP
cord-269011-230p8rsf	692	25	apparatus	apparatus	NN
cord-269011-230p8rsf	692	26	but	but	CC
cord-269011-230p8rsf	692	27	transported	transport	VBN
cord-269011-230p8rsf	692	28	to	to	IN
cord-269011-230p8rsf	692	29	the	the	DT
cord-269011-230p8rsf	692	30	cell	cell	NN
cord-269011-230p8rsf	692	31	surface	surface	NN
cord-269011-230p8rsf	692	32	.	.	.
cord-269011-230p8rsf	693	1	Apparently	apparently	RB
cord-269011-230p8rsf	693	2	,	,	,
cord-269011-230p8rsf	693	3	the	the	DT
cord-269011-230p8rsf	693	4	tail	tail	NN
cord-269011-230p8rsf	693	5	domain	domain	NN
cord-269011-230p8rsf	693	6	is	be	VBZ
cord-269011-230p8rsf	693	7	not	not	RB
cord-269011-230p8rsf	693	8	essential	essential	JJ
cord-269011-230p8rsf	693	9	for	for	IN
cord-269011-230p8rsf	693	10	the	the	DT
cord-269011-230p8rsf	693	11	lateral	lateral	JJ
cord-269011-230p8rsf	693	12	interactions	interaction	NNS
cord-269011-230p8rsf	693	13	between	between	IN
cord-269011-230p8rsf	693	14	M	M	NNP
cord-269011-230p8rsf	693	15	proteins	protein	NNS
cord-269011-230p8rsf	693	16	,	,	,
cord-269011-230p8rsf	693	17	but	but	CC
cord-269011-230p8rsf	693	18	it	-PRON-	PRP
cord-269011-230p8rsf	693	19	is	be	VBZ
cord-269011-230p8rsf	693	20	critically	critically	RB
cord-269011-230p8rsf	693	21	required	require	VBN
cord-269011-230p8rsf	693	22	for	for	IN
cord-269011-230p8rsf	693	23	budding	bud	VBG
cord-269011-230p8rsf	693	24	(	(	-LRB-
cord-269011-230p8rsf	693	25	de	de	FW
cord-269011-230p8rsf	693	26	Haan	Haan	NNP
cord-269011-230p8rsf	693	27	et	et	FW
cord-269011-230p8rsf	693	28	al	al	NNP
cord-269011-230p8rsf	693	29	.	.	NNP
cord-269011-230p8rsf	693	30	,	,	,
cord-269011-230p8rsf	693	31	1998a	1998a	CD
cord-269011-230p8rsf	693	32	.	.	.
cord-269011-230p8rsf	694	1	Similar	similar	JJ
cord-269011-230p8rsf	694	2	higher	high	JJR
cord-269011-230p8rsf	694	3	order	order	NN
cord-269011-230p8rsf	694	4	complexes	complex	NNS
cord-269011-230p8rsf	694	5	of	of	IN
cord-269011-230p8rsf	694	6	the	the	DT
cord-269011-230p8rsf	694	7	M	M	NNP
cord-269011-230p8rsf	694	8	protein	protein	NN
cord-269011-230p8rsf	694	9	have	have	VBP
cord-269011-230p8rsf	694	10	also	also	RB
cord-269011-230p8rsf	694	11	been	be	VBN
cord-269011-230p8rsf	694	12	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	694	13	in	in	IN
cord-269011-230p8rsf	694	14	MHV	MHV	NNP
cord-269011-230p8rsf	694	15	-	-	HYPH
cord-269011-230p8rsf	694	16	infected	infect	VBN
cord-269011-230p8rsf	694	17	cells	cell	NNS
cord-269011-230p8rsf	694	18	as	as	RB
cord-269011-230p8rsf	694	19	well	well	RB
cord-269011-230p8rsf	694	20	as	as	IN
cord-269011-230p8rsf	694	21	in	in	IN
cord-269011-230p8rsf	694	22	MHV	MHV	NNP
cord-269011-230p8rsf	694	23	virions	virion	NNS
cord-269011-230p8rsf	694	24	(	(	-LRB-
cord-269011-230p8rsf	695	1	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	695	2	et	et	NNP
cord-269011-230p8rsf	695	3	al	al	NNP
cord-269011-230p8rsf	695	4	.	.	NNP
cord-269011-230p8rsf	695	5	,	,	,
cord-269011-230p8rsf	695	6	1993b	1993b	CD
cord-269011-230p8rsf	695	7	.	.	.
cord-269011-230p8rsf	696	1	Further	further	JJ
cord-269011-230p8rsf	696	2	support	support	NN
cord-269011-230p8rsf	696	3	for	for	IN
cord-269011-230p8rsf	696	4	the	the	DT
cord-269011-230p8rsf	696	5	existence	existence	NN
cord-269011-230p8rsf	696	6	of	of	IN
cord-269011-230p8rsf	696	7	homotypic	homotypic	NNP
cord-269011-230p8rsf	696	8	M	M	NNP
cord-269011-230p8rsf	696	9	protein	protein	NN
cord-269011-230p8rsf	696	10	interactions	interaction	NNS
cord-269011-230p8rsf	696	11	and	and	CC
cord-269011-230p8rsf	696	12	additional	additional	JJ
cord-269011-230p8rsf	696	13	insight	insight	NN
cord-269011-230p8rsf	696	14	into	into	IN
cord-269011-230p8rsf	696	15	the	the	DT
cord-269011-230p8rsf	696	16	domains	domain	NNS
cord-269011-230p8rsf	696	17	involved	involve	VBN
cord-269011-230p8rsf	696	18	in	in	IN
cord-269011-230p8rsf	696	19	these	these	DT
cord-269011-230p8rsf	696	20	interactions	interaction	NNS
cord-269011-230p8rsf	696	21	came	come	VBD
cord-269011-230p8rsf	696	22	from	from	IN
cord-269011-230p8rsf	696	23	work	work	NN
cord-269011-230p8rsf	696	24	with	with	IN
cord-269011-230p8rsf	696	25	mutant	mutant	JJ
cord-269011-230p8rsf	696	26	M	M	NNP
cord-269011-230p8rsf	696	27	proteins	protein	NNS
cord-269011-230p8rsf	696	28	that	that	WDT
cord-269011-230p8rsf	696	29	are	be	VBP
cord-269011-230p8rsf	696	30	unable	unable	JJ
cord-269011-230p8rsf	696	31	to	to	TO
cord-269011-230p8rsf	696	32	assemble	assemble	VB
cord-269011-230p8rsf	696	33	into	into	IN
cord-269011-230p8rsf	696	34	VLPs	vlp	NNS
cord-269011-230p8rsf	696	35	.	.	.
cord-269011-230p8rsf	697	1	In	in	IN
cord-269011-230p8rsf	697	2	these	these	DT
cord-269011-230p8rsf	697	3	studies	study	NNS
cord-269011-230p8rsf	697	4	MHV	MHV	NNP
cord-269011-230p8rsf	697	5	M	M	NNP
cord-269011-230p8rsf	697	6	proteins	protein	NNS
cord-269011-230p8rsf	697	7	with	with	IN
cord-269011-230p8rsf	697	8	deletions	deletion	NNS
cord-269011-230p8rsf	697	9	in	in	IN
cord-269011-230p8rsf	697	10	either	either	CC
cord-269011-230p8rsf	697	11	the	the	DT
cord-269011-230p8rsf	697	12	transmembrane	transmembrane	NN
cord-269011-230p8rsf	697	13	regions	region	NNS
cord-269011-230p8rsf	697	14	,	,	,
cord-269011-230p8rsf	697	15	the	the	DT
cord-269011-230p8rsf	697	16	amphipathic	amphipathic	NNP
cord-269011-230p8rsf	697	17	domain	domain	NN
cord-269011-230p8rsf	697	18	,	,	,
cord-269011-230p8rsf	697	19	or	or	CC
cord-269011-230p8rsf	697	20	the	the	DT
cord-269011-230p8rsf	697	21	extreme	extreme	JJ
cord-269011-230p8rsf	697	22	carboxy	carboxy	JJ
cord-269011-230p8rsf	697	23	terminus	terminus	NN
cord-269011-230p8rsf	697	24	or	or	CC
cord-269011-230p8rsf	697	25	with	with	IN
cord-269011-230p8rsf	697	26	substitutions	substitution	NNS
cord-269011-230p8rsf	697	27	of	of	IN
cord-269011-230p8rsf	697	28	the	the	DT
cord-269011-230p8rsf	697	29	lumenal	lumenal	JJ
cord-269011-230p8rsf	697	30	domain	domain	NN
cord-269011-230p8rsf	697	31	were	be	VBD
cord-269011-230p8rsf	697	32	tested	test	VBN
cord-269011-230p8rsf	697	33	for	for	IN
cord-269011-230p8rsf	697	34	their	-PRON-	PRP$
cord-269011-230p8rsf	697	35	ability	ability	NN
cord-269011-230p8rsf	697	36	to	to	TO
cord-269011-230p8rsf	697	37	associate	associate	VB
cord-269011-230p8rsf	697	38	with	with	IN
cord-269011-230p8rsf	697	39	other	other	JJ
cord-269011-230p8rsf	697	40	M	M	NNP
cord-269011-230p8rsf	697	41	proteins	protein	NNS
cord-269011-230p8rsf	697	42	and	and	CC
cord-269011-230p8rsf	697	43	to	to	TO
cord-269011-230p8rsf	697	44	be	be	VB
cord-269011-230p8rsf	697	45	rescued	rescue	VBN
cord-269011-230p8rsf	697	46	into	into	IN
cord-269011-230p8rsf	697	47	VLPs	vlp	NNS
cord-269011-230p8rsf	697	48	formed	form	VBN
cord-269011-230p8rsf	697	49	by	by	IN
cord-269011-230p8rsf	697	50	assembly	assembly	NN
cord-269011-230p8rsf	697	51	-	-	HYPH
cord-269011-230p8rsf	697	52	competent	competent	JJ
cord-269011-230p8rsf	697	53	M	M	NNP
cord-269011-230p8rsf	697	54	proteins	protein	NNS
cord-269011-230p8rsf	697	55	(	(	-LRB-
cord-269011-230p8rsf	697	56	de	de	FW
cord-269011-230p8rsf	697	57	Haan	Haan	NNP
cord-269011-230p8rsf	697	58	et	et	FW
cord-269011-230p8rsf	697	59	al	al	NNP
cord-269011-230p8rsf	697	60	.	.	NNP
cord-269011-230p8rsf	697	61	,	,	,
cord-269011-230p8rsf	697	62	1998a	1998a	CD
cord-269011-230p8rsf	697	63	.	.	.
cord-269011-230p8rsf	698	1	It	-PRON-	PRP
cord-269011-230p8rsf	698	2	appeared	appear	VBD
cord-269011-230p8rsf	698	3	that	that	IN
cord-269011-230p8rsf	698	4	the	the	DT
cord-269011-230p8rsf	698	5	mutant	mutant	JJ
cord-269011-230p8rsf	698	6	proteins	protein	NNS
cord-269011-230p8rsf	698	7	maintained	maintain	VBD
cord-269011-230p8rsf	698	8	these	these	DT
cord-269011-230p8rsf	698	9	biological	biological	JJ
cord-269011-230p8rsf	698	10	activities	activity	NNS
cord-269011-230p8rsf	698	11	despite	despite	IN
cord-269011-230p8rsf	698	12	the	the	DT
cord-269011-230p8rsf	698	13	often	often	RB
cord-269011-230p8rsf	698	14	severe	severe	JJ
cord-269011-230p8rsf	698	15	alterations	alteration	NNS
cord-269011-230p8rsf	698	16	;	;	:
cord-269011-230p8rsf	698	17	actually	actually	RB
cord-269011-230p8rsf	698	18	,	,	,
cord-269011-230p8rsf	698	19	the	the	DT
cord-269011-230p8rsf	698	20	only	only	JJ
cord-269011-230p8rsf	698	21	mutant	mutant	JJ
cord-269011-230p8rsf	698	22	protein	protein	NN
cord-269011-230p8rsf	698	23	that	that	WDT
cord-269011-230p8rsf	698	24	had	have	VBD
cord-269011-230p8rsf	698	25	lost	lose	VBN
cord-269011-230p8rsf	698	26	these	these	DT
cord-269011-230p8rsf	698	27	abilities	ability	NNS
cord-269011-230p8rsf	698	28	was	be	VBD
cord-269011-230p8rsf	698	29	one	one	CD
cord-269011-230p8rsf	698	30	in	in	IN
cord-269011-230p8rsf	698	31	which	which	WDT
cord-269011-230p8rsf	698	32	all	all	DT
cord-269011-230p8rsf	698	33	three	three	CD
cord-269011-230p8rsf	698	34	transmembrane	transmembrane	NN
cord-269011-230p8rsf	698	35	domains	domain	NNS
cord-269011-230p8rsf	698	36	had	have	VBD
cord-269011-230p8rsf	698	37	been	be	VBN
cord-269011-230p8rsf	698	38	replaced	replace	VBN
cord-269011-230p8rsf	698	39	by	by	IN
cord-269011-230p8rsf	698	40	a	a	DT
cord-269011-230p8rsf	698	41	heterologous	heterologous	JJ
cord-269011-230p8rsf	698	42	transmembrane	transmembrane	NN
cord-269011-230p8rsf	698	43	domain	domain	NN
cord-269011-230p8rsf	698	44	.	.	.
cord-269011-230p8rsf	699	1	It	-PRON-	PRP
cord-269011-230p8rsf	699	2	was	be	VBD
cord-269011-230p8rsf	699	3	concluded	conclude	VBN
cord-269011-230p8rsf	699	4	that	that	IN
cord-269011-230p8rsf	699	5	M	M	NNP
cord-269011-230p8rsf	699	6	protein	protein	NN
cord-269011-230p8rsf	699	7	molecules	molecule	NNS
cord-269011-230p8rsf	699	8	interact	interact	VBP
cord-269011-230p8rsf	699	9	with	with	IN
cord-269011-230p8rsf	699	10	each	each	DT
cord-269011-230p8rsf	699	11	other	other	JJ
cord-269011-230p8rsf	699	12	through	through	IN
cord-269011-230p8rsf	699	13	multiple	multiple	JJ
cord-269011-230p8rsf	699	14	contact	contact	NN
cord-269011-230p8rsf	699	15	sites	site	NNS
cord-269011-230p8rsf	699	16	,	,	,
cord-269011-230p8rsf	699	17	particularly	particularly	RB
cord-269011-230p8rsf	699	18	at	at	IN
cord-269011-230p8rsf	699	19	the	the	DT
cord-269011-230p8rsf	699	20	transmembrane	transmembrane	JJ
cord-269011-230p8rsf	699	21	level	level	NN
cord-269011-230p8rsf	699	22	.	.	.
cord-269011-230p8rsf	700	1	It	-PRON-	PRP
cord-269011-230p8rsf	700	2	was	be	VBD
cord-269011-230p8rsf	700	3	furthermore	furthermore	RB
cord-269011-230p8rsf	700	4	hypothesized	hypothesize	VBN
cord-269011-230p8rsf	700	5	that	that	IN
cord-269011-230p8rsf	700	6	the	the	DT
cord-269011-230p8rsf	700	7	full	full	JJ
cord-269011-230p8rsf	700	8	complement	complement	NN
cord-269011-230p8rsf	700	9	of	of	IN
cord-269011-230p8rsf	700	10	interactions	interaction	NNS
cord-269011-230p8rsf	700	11	between	between	IN
cord-269011-230p8rsf	700	12	the	the	DT
cord-269011-230p8rsf	700	13	M	M	NNP
cord-269011-230p8rsf	700	14	molecules	molecule	NNS
cord-269011-230p8rsf	700	15	is	be	VBZ
cord-269011-230p8rsf	700	16	required	require	VBN
cord-269011-230p8rsf	700	17	for	for	IN
cord-269011-230p8rsf	700	18	efficient	efficient	JJ
cord-269011-230p8rsf	700	19	particle	particle	NN
cord-269011-230p8rsf	700	20	formation	formation	NN
cord-269011-230p8rsf	700	21	;	;	:
cord-269011-230p8rsf	700	22	possibly	possibly	RB
cord-269011-230p8rsf	700	23	,	,	,
cord-269011-230p8rsf	700	24	all	all	PDT
cord-269011-230p8rsf	700	25	these	these	DT
cord-269011-230p8rsf	700	26	interactions	interaction	NNS
cord-269011-230p8rsf	700	27	are	be	VBP
cord-269011-230p8rsf	700	28	required	require	VBN
cord-269011-230p8rsf	700	29	to	to	TO
cord-269011-230p8rsf	700	30	provide	provide	VB
cord-269011-230p8rsf	700	31	the	the	DT
cord-269011-230p8rsf	700	32	free	free	JJ
cord-269011-230p8rsf	700	33	energy	energy	NN
cord-269011-230p8rsf	700	34	to	to	TO
cord-269011-230p8rsf	700	35	generate	generate	VB
cord-269011-230p8rsf	700	36	and	and	CC
cord-269011-230p8rsf	700	37	stabilize	stabilize	VB
cord-269011-230p8rsf	700	38	the	the	DT
cord-269011-230p8rsf	700	39	budding	bud	VBG
cord-269011-230p8rsf	700	40	envelope	envelope	NN
cord-269011-230p8rsf	700	41	.	.	.
cord-269011-230p8rsf	701	1	The	the	DT
cord-269011-230p8rsf	701	2	failure	failure	NN
cord-269011-230p8rsf	701	3	of	of	IN
cord-269011-230p8rsf	701	4	M	M	NNP
cord-269011-230p8rsf	701	5	protein	protein	NN
cord-269011-230p8rsf	701	6	mutants	mutant	NNS
cord-269011-230p8rsf	701	7	capable	capable	JJ
cord-269011-230p8rsf	701	8	of	of	IN
cord-269011-230p8rsf	701	9	associating	associate	VBG
cord-269011-230p8rsf	701	10	with	with	IN
cord-269011-230p8rsf	701	11	assembly	assembly	NN
cord-269011-230p8rsf	701	12	-	-	HYPH
cord-269011-230p8rsf	701	13	competent	competent	JJ
cord-269011-230p8rsf	701	14	M	M	NNP
cord-269011-230p8rsf	701	15	protein	protein	NN
cord-269011-230p8rsf	701	16	to	to	TO
cord-269011-230p8rsf	701	17	assemble	assemble	VB
cord-269011-230p8rsf	701	18	into	into	IN
cord-269011-230p8rsf	701	19	VLPs	vlp	NNS
cord-269011-230p8rsf	701	20	by	by	IN
cord-269011-230p8rsf	701	21	themselves	-PRON-	PRP
cord-269011-230p8rsf	701	22	(	(	-LRB-
cord-269011-230p8rsf	701	23	de	de	FW
cord-269011-230p8rsf	701	24	Haan	Haan	NNP
cord-269011-230p8rsf	701	25	et	et	FW
cord-269011-230p8rsf	701	26	al	al	NNP
cord-269011-230p8rsf	701	27	.	.	.
cord-269011-230p8rsf	702	1	,	,	,
cord-269011-230p8rsf	702	2	1998a	1998a	CD
cord-269011-230p8rsf	702	3	indicates	indicate	VBZ
cord-269011-230p8rsf	702	4	that	that	IN
cord-269011-230p8rsf	702	5	additional	additional	JJ
cord-269011-230p8rsf	702	6	interactions	interaction	NNS
cord-269011-230p8rsf	702	7	with	with	IN
cord-269011-230p8rsf	702	8	viral	viral	JJ
cord-269011-230p8rsf	702	9	(	(	-LRB-
cord-269011-230p8rsf	702	10	E	e	NN
cord-269011-230p8rsf	702	11	)	)	-RRB-
cord-269011-230p8rsf	702	12	and/or	and/or	CC
cord-269011-230p8rsf	702	13	host	host	NN
cord-269011-230p8rsf	702	14	proteins	protein	NNS
cord-269011-230p8rsf	702	15	is	be	VBZ
cord-269011-230p8rsf	702	16	required	require	VBN
cord-269011-230p8rsf	702	17	.	.	.
cord-269011-230p8rsf	703	1	In	in	IN
cord-269011-230p8rsf	703	2	this	this	DT
cord-269011-230p8rsf	703	3	respect	respect	NN
cord-269011-230p8rsf	703	4	it	-PRON-	PRP
cord-269011-230p8rsf	703	5	is	be	VBZ
cord-269011-230p8rsf	703	6	of	of	IN
cord-269011-230p8rsf	703	7	note	note	NN
cord-269011-230p8rsf	703	8	that	that	IN
cord-269011-230p8rsf	703	9	the	the	DT
cord-269011-230p8rsf	703	10	IFN	IFN	NNP
cord-269011-230p8rsf	703	11	-	-	HYPH
cord-269011-230p8rsf	703	12	inducing	induce	VBG
cord-269011-230p8rsf	703	13	capacity	capacity	NN
cord-269011-230p8rsf	703	14	of	of	IN
cord-269011-230p8rsf	703	15	the	the	DT
cord-269011-230p8rsf	703	16	M	M	NNP
cord-269011-230p8rsf	703	17	protein	protein	NN
cord-269011-230p8rsf	703	18	,	,	,
cord-269011-230p8rsf	703	19	demonstrated	demonstrate	VBD
cord-269011-230p8rsf	703	20	for	for	IN
cord-269011-230p8rsf	703	21	TGEV	TGEV	NNP
cord-269011-230p8rsf	703	22	and	and	CC
cord-269011-230p8rsf	703	23	BCoV	BCoV	NNP
cord-269011-230p8rsf	703	24	,	,	,
cord-269011-230p8rsf	703	25	also	also	RB
cord-269011-230p8rsf	703	26	requires	require	VBZ
cord-269011-230p8rsf	703	27	the	the	DT
cord-269011-230p8rsf	703	28	presence	presence	NN
cord-269011-230p8rsf	703	29	of	of	IN
cord-269011-230p8rsf	703	30	the	the	DT
cord-269011-230p8rsf	703	31	E	e	NN
cord-269011-230p8rsf	703	32	protein	protein	NN
cord-269011-230p8rsf	703	33	,	,	,
cord-269011-230p8rsf	703	34	which	which	WDT
cord-269011-230p8rsf	703	35	suggests	suggest	VBZ
cord-269011-230p8rsf	703	36	that	that	IN
cord-269011-230p8rsf	703	37	the	the	DT
cord-269011-230p8rsf	703	38	induction	induction	NN
cord-269011-230p8rsf	703	39	of	of	IN
cord-269011-230p8rsf	703	40	IFN	IFN	NNP
cord-269011-230p8rsf	703	41	is	be	VBZ
cord-269011-230p8rsf	703	42	dependent	dependent	JJ
cord-269011-230p8rsf	703	43	on	on	IN
cord-269011-230p8rsf	703	44	a	a	DT
cord-269011-230p8rsf	703	45	specific	specific	JJ
cord-269011-230p8rsf	703	46	,	,	,
cord-269011-230p8rsf	703	47	probably	probably	RB
cord-269011-230p8rsf	703	48	regularly	regularly	RB
cord-269011-230p8rsf	703	49	organized	organize	VBD
cord-269011-230p8rsf	703	50	structure	structure	NN
cord-269011-230p8rsf	703	51	of	of	IN
cord-269011-230p8rsf	703	52	the	the	DT
cord-269011-230p8rsf	703	53	M	M	NNP
cord-269011-230p8rsf	703	54	protein	protein	NN
cord-269011-230p8rsf	703	55	(	(	-LRB-
cord-269011-230p8rsf	703	56	Baudoux	Baudoux	NNP
cord-269011-230p8rsf	703	57	et	et	NNP
cord-269011-230p8rsf	703	58	al	al	NNP
cord-269011-230p8rsf	703	59	.	.	NNP
cord-269011-230p8rsf	703	60	,	,	,
cord-269011-230p8rsf	703	61	1998a	1998a	CD
cord-269011-230p8rsf	703	62	,	,	,
cord-269011-230p8rsf	703	63	b	b	LS
cord-269011-230p8rsf	703	64	)	)	-RRB-
cord-269011-230p8rsf	703	65	.	.	.
cord-269011-230p8rsf	704	1	It	-PRON-	PRP
cord-269011-230p8rsf	704	2	is	be	VBZ
cord-269011-230p8rsf	704	3	unclear	unclear	JJ
cord-269011-230p8rsf	704	4	how	how	WRB
cord-269011-230p8rsf	704	5	the	the	DT
cord-269011-230p8rsf	704	6	presence	presence	NN
cord-269011-230p8rsf	704	7	of	of	IN
cord-269011-230p8rsf	704	8	the	the	DT
cord-269011-230p8rsf	704	9	E	e	NN
cord-269011-230p8rsf	704	10	protein	protein	NN
cord-269011-230p8rsf	704	11	alters	alter	VBZ
cord-269011-230p8rsf	704	12	the	the	DT
cord-269011-230p8rsf	704	13	M	M	NNP
cord-269011-230p8rsf	704	14	protein	protein	NN
cord-269011-230p8rsf	704	15	lattice	lattice	NN
cord-269011-230p8rsf	704	16	to	to	TO
cord-269011-230p8rsf	704	17	achieve	achieve	VB
cord-269011-230p8rsf	704	18	this	this	DT
cord-269011-230p8rsf	704	19	effect	effect	NN
cord-269011-230p8rsf	704	20	.	.	.
cord-269011-230p8rsf	705	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	705	2	envelope	envelope	NN
cord-269011-230p8rsf	705	3	assembly	assembly	NN
cord-269011-230p8rsf	705	4	is	be	VBZ
cord-269011-230p8rsf	705	5	not	not	RB
cord-269011-230p8rsf	705	6	dependent	dependent	JJ
cord-269011-230p8rsf	705	7	on	on	IN
cord-269011-230p8rsf	705	8	the	the	DT
cord-269011-230p8rsf	705	9	S	S	NNP
cord-269011-230p8rsf	705	10	protein	protein	NN
cord-269011-230p8rsf	705	11	or	or	CC
cord-269011-230p8rsf	705	12	the	the	DT
cord-269011-230p8rsf	705	13	HE	HE	NNP
cord-269011-230p8rsf	705	14	protein	protein	NN
cord-269011-230p8rsf	705	15	.	.	.
cord-269011-230p8rsf	706	1	This	this	DT
cord-269011-230p8rsf	706	2	is	be	VBZ
cord-269011-230p8rsf	706	3	obvious	obvious	JJ
cord-269011-230p8rsf	706	4	from	from	IN
cord-269011-230p8rsf	706	5	work	work	NN
cord-269011-230p8rsf	706	6	with	with	IN
cord-269011-230p8rsf	706	7	VLPs	vlp	NNS
cord-269011-230p8rsf	706	8	as	as	RB
cord-269011-230p8rsf	706	9	well	well	RB
cord-269011-230p8rsf	706	10	as	as	IN
cord-269011-230p8rsf	706	11	with	with	IN
cord-269011-230p8rsf	706	12	viruses	virus	NNS
cord-269011-230p8rsf	706	13	showing	show	VBG
cord-269011-230p8rsf	706	14	that	that	IN
cord-269011-230p8rsf	706	15	bona	bona	JJ
cord-269011-230p8rsf	706	16	fide	fide	JJ
cord-269011-230p8rsf	706	17	particles	particle	NNS
cord-269011-230p8rsf	706	18	were	be	VBD
cord-269011-230p8rsf	706	19	produced	produce	VBN
cord-269011-230p8rsf	706	20	when	when	WRB
cord-269011-230p8rsf	706	21	these	these	DT
cord-269011-230p8rsf	706	22	proteins	protein	NNS
cord-269011-230p8rsf	706	23	were	be	VBD
cord-269011-230p8rsf	706	24	either	either	CC
cord-269011-230p8rsf	706	25	simply	simply	RB
cord-269011-230p8rsf	706	26	absent	absent	JJ
cord-269011-230p8rsf	706	27	or	or	CC
cord-269011-230p8rsf	706	28	unavailable	unavailable	JJ
cord-269011-230p8rsf	706	29	for	for	IN
cord-269011-230p8rsf	706	30	assembly	assembly	NN
cord-269011-230p8rsf	706	31	.	.	.
cord-269011-230p8rsf	707	1	Availability	availability	NN
cord-269011-230p8rsf	707	2	can	can	MD
cord-269011-230p8rsf	707	3	be	be	VB
cord-269011-230p8rsf	707	4	compromised	compromise	VBN
cord-269011-230p8rsf	707	5	under	under	IN
cord-269011-230p8rsf	707	6	conditions	condition	NNS
cord-269011-230p8rsf	707	7	in	in	IN
cord-269011-230p8rsf	707	8	which	which	WDT
cord-269011-230p8rsf	707	9	proper	proper	JJ
cord-269011-230p8rsf	707	10	folding	folding	NN
cord-269011-230p8rsf	707	11	of	of	IN
cord-269011-230p8rsf	707	12	the	the	DT
cord-269011-230p8rsf	707	13	proteins	protein	NNS
cord-269011-230p8rsf	707	14	is	be	VBZ
cord-269011-230p8rsf	707	15	affected	affect	VBN
cord-269011-230p8rsf	707	16	.	.	.
cord-269011-230p8rsf	708	1	Inhibition	inhibition	NN
cord-269011-230p8rsf	708	2	of	of	IN
cord-269011-230p8rsf	708	3	N	n	NN
cord-269011-230p8rsf	708	4	-	-	HYPH
cord-269011-230p8rsf	708	5	glycosylation	glycosylation	NN
cord-269011-230p8rsf	708	6	by	by	IN
cord-269011-230p8rsf	708	7	the	the	DT
cord-269011-230p8rsf	708	8	drug	drug	NN
cord-269011-230p8rsf	708	9	tunicamycin	tunicamycin	NNS
cord-269011-230p8rsf	708	10	,	,	,
cord-269011-230p8rsf	708	11	for	for	IN
cord-269011-230p8rsf	708	12	instance	instance	NN
cord-269011-230p8rsf	708	13	,	,	,
cord-269011-230p8rsf	708	14	can	can	MD
cord-269011-230p8rsf	708	15	lead	lead	VB
cord-269011-230p8rsf	708	16	to	to	IN
cord-269011-230p8rsf	708	17	aggregation	aggregation	NN
cord-269011-230p8rsf	708	18	and	and	CC
cord-269011-230p8rsf	708	19	retention	retention	NN
cord-269011-230p8rsf	708	20	of	of	IN
cord-269011-230p8rsf	708	21	membrane	membrane	NN
cord-269011-230p8rsf	708	22	proteins	protein	NNS
cord-269011-230p8rsf	708	23	in	in	IN
cord-269011-230p8rsf	708	24	the	the	DT
cord-269011-230p8rsf	708	25	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	708	26	reticulum	reticulum	NN
cord-269011-230p8rsf	708	27	and	and	CC
cord-269011-230p8rsf	708	28	has	have	VBZ
cord-269011-230p8rsf	708	29	been	be	VBN
cord-269011-230p8rsf	708	30	shown	show	VBN
cord-269011-230p8rsf	708	31	to	to	TO
cord-269011-230p8rsf	708	32	prevent	prevent	VB
cord-269011-230p8rsf	708	33	the	the	DT
cord-269011-230p8rsf	708	34	incorporation	incorporation	NN
cord-269011-230p8rsf	708	35	into	into	IN
cord-269011-230p8rsf	708	36	virions	virion	NNS
cord-269011-230p8rsf	708	37	of	of	IN
cord-269011-230p8rsf	708	38	both	both	CC
cord-269011-230p8rsf	708	39	the	the	DT
cord-269011-230p8rsf	708	40	S	S	NNP
cord-269011-230p8rsf	708	41	protein	protein	NN
cord-269011-230p8rsf	708	42	Mounir	Mounir	NNP
cord-269011-230p8rsf	708	43	and	and	CC
cord-269011-230p8rsf	708	44	Talbot	Talbot	NNP
cord-269011-230p8rsf	708	45	,	,	,
cord-269011-230p8rsf	708	46	1992	1992	CD
cord-269011-230p8rsf	708	47	;	;	:
cord-269011-230p8rsf	708	48	Rottier	Rottier	NNP
cord-269011-230p8rsf	708	49	et	et	NNP
cord-269011-230p8rsf	708	50	al	al	NNP
cord-269011-230p8rsf	708	51	.	.	NNP
cord-269011-230p8rsf	708	52	,	,	,
cord-269011-230p8rsf	708	53	1981a	1981a	CD
cord-269011-230p8rsf	708	54	;	;	:
cord-269011-230p8rsf	708	55	Stern	Stern	NNP
cord-269011-230p8rsf	708	56	and	and	CC
cord-269011-230p8rsf	708	57	Sefton	Sefton	NNP
cord-269011-230p8rsf	708	58	,	,	,
cord-269011-230p8rsf	708	59	1982	1982	CD
cord-269011-230p8rsf	708	60	)	)	-RRB-
cord-269011-230p8rsf	708	61	and	and	CC
cord-269011-230p8rsf	708	62	the	the	DT
cord-269011-230p8rsf	708	63	HE	HE	NNP
cord-269011-230p8rsf	708	64	protein	protein	NN
cord-269011-230p8rsf	708	65	(	(	-LRB-
cord-269011-230p8rsf	708	66	Mounir	Mounir	NNP
cord-269011-230p8rsf	708	67	and	and	CC
cord-269011-230p8rsf	708	68	Talbot	Talbot	NNP
cord-269011-230p8rsf	708	69	,	,	,
cord-269011-230p8rsf	708	70	1992	1992	CD
cord-269011-230p8rsf	708	71	)	)	-RRB-
cord-269011-230p8rsf	708	72	.	.	.
cord-269011-230p8rsf	709	1	The	the	DT
cord-269011-230p8rsf	709	2	same	same	JJ
cord-269011-230p8rsf	709	3	effect	effect	NN
cord-269011-230p8rsf	709	4	has	have	VBZ
cord-269011-230p8rsf	709	5	been	be	VBN
cord-269011-230p8rsf	709	6	observed	observe	VBN
cord-269011-230p8rsf	709	7	with	with	IN
cord-269011-230p8rsf	709	8	temperature	temperature	NN
cord-269011-230p8rsf	709	9	-	-	HYPH
cord-269011-230p8rsf	709	10	sensitive	sensitive	JJ
cord-269011-230p8rsf	709	11	MHV	MHV	NNP
cord-269011-230p8rsf	709	12	mutants	mutant	NNS
cord-269011-230p8rsf	709	13	carrying	carry	VBG
cord-269011-230p8rsf	709	14	defects	defect	NNS
cord-269011-230p8rsf	709	15	in	in	IN
cord-269011-230p8rsf	709	16	their	-PRON-	PRP$
cord-269011-230p8rsf	709	17	S	S	NNP
cord-269011-230p8rsf	709	18	gene	gene	NN
cord-269011-230p8rsf	709	19	,	,	,
cord-269011-230p8rsf	709	20	which	which	WDT
cord-269011-230p8rsf	709	21	,	,	,
cord-269011-230p8rsf	709	22	when	when	WRB
cord-269011-230p8rsf	709	23	grown	grow	VBN
cord-269011-230p8rsf	709	24	at	at	IN
cord-269011-230p8rsf	709	25	the	the	DT
cord-269011-230p8rsf	709	26	restrictive	restrictive	JJ
cord-269011-230p8rsf	709	27	temperature	temperature	NN
cord-269011-230p8rsf	709	28	,	,	,
cord-269011-230p8rsf	709	29	gave	give	VBD
cord-269011-230p8rsf	709	30	rise	rise	NN
cord-269011-230p8rsf	709	31	to	to	IN
cord-269011-230p8rsf	709	32	spikeless	spikeless	NN
cord-269011-230p8rsf	709	33	particles	particle	NNS
cord-269011-230p8rsf	709	34	Ricard	Ricard	NNP
cord-269011-230p8rsf	709	35	et	et	NNP
cord-269011-230p8rsf	709	36	al	al	NNP
cord-269011-230p8rsf	709	37	.	.	NNP
cord-269011-230p8rsf	709	38	,	,	,
cord-269011-230p8rsf	709	39	1995	1995	CD
cord-269011-230p8rsf	709	40	)	)	-RRB-
cord-269011-230p8rsf	709	41	.	.	.
cord-269011-230p8rsf	710	1	Both	both	DT
cord-269011-230p8rsf	710	2	S	S	NNP
cord-269011-230p8rsf	710	3	and	and	CC
cord-269011-230p8rsf	710	4	HE	HE	NNP
cord-269011-230p8rsf	710	5	proteins	protein	NNS
cord-269011-230p8rsf	710	6	are	be	VBP
cord-269011-230p8rsf	710	7	assembled	assemble	VBN
cord-269011-230p8rsf	710	8	into	into	IN
cord-269011-230p8rsf	710	9	the	the	DT
cord-269011-230p8rsf	710	10	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	710	11	envelope	envelope	NN
cord-269011-230p8rsf	710	12	through	through	IN
cord-269011-230p8rsf	710	13	interactions	interaction	NNS
cord-269011-230p8rsf	710	14	with	with	IN
cord-269011-230p8rsf	710	15	the	the	DT
cord-269011-230p8rsf	710	16	M	M	NNP
cord-269011-230p8rsf	710	17	protein	protein	NN
cord-269011-230p8rsf	710	18	.	.	.
cord-269011-230p8rsf	711	1	Such	such	JJ
cord-269011-230p8rsf	711	2	interactions	interaction	NNS
cord-269011-230p8rsf	711	3	have	have	VBP
cord-269011-230p8rsf	711	4	been	be	VBN
cord-269011-230p8rsf	711	5	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	711	6	for	for	IN
cord-269011-230p8rsf	711	7	MHV	MHV	NNP
cord-269011-230p8rsf	711	8	and	and	CC
cord-269011-230p8rsf	711	9	BCoV	BCoV	NNP
cord-269011-230p8rsf	711	10	M	M	NNP
cord-269011-230p8rsf	711	11	and	and	CC
cord-269011-230p8rsf	711	12	S	S	NNP
cord-269011-230p8rsf	711	13	proteins	protein	NNS
cord-269011-230p8rsf	711	14	and	and	CC
cord-269011-230p8rsf	711	15	for	for	IN
cord-269011-230p8rsf	711	16	BCoV	BCoV	NNP
cord-269011-230p8rsf	711	17	M	M	NNP
cord-269011-230p8rsf	711	18	and	and	CC
cord-269011-230p8rsf	711	19	HE	HE	NNP
cord-269011-230p8rsf	711	20	proteins	protein	VBZ
cord-269011-230p8rsf	711	21	,	,	,
cord-269011-230p8rsf	711	22	in	in	IN
cord-269011-230p8rsf	711	23	infected	infected	JJ
cord-269011-230p8rsf	711	24	cells	cell	NNS
cord-269011-230p8rsf	711	25	,	,	,
cord-269011-230p8rsf	711	26	in	in	IN
cord-269011-230p8rsf	711	27	cells	cell	NNS
cord-269011-230p8rsf	711	28	coexpressing	coexpresse	VBG
cord-269011-230p8rsf	711	29	the	the	DT
cord-269011-230p8rsf	711	30	proteins	protein	NNS
cord-269011-230p8rsf	711	31	,	,	,
cord-269011-230p8rsf	711	32	and	and	CC
cord-269011-230p8rsf	711	33	in	in	IN
cord-269011-230p8rsf	711	34	virions	virion	NNS
cord-269011-230p8rsf	711	35	(	(	-LRB-
cord-269011-230p8rsf	711	36	Nguyen	Nguyen	NNP
cord-269011-230p8rsf	711	37	and	and	CC
cord-269011-230p8rsf	711	38	Hogue	Hogue	NNP
cord-269011-230p8rsf	711	39	,	,	,
cord-269011-230p8rsf	711	40	1997	1997	CD
cord-269011-230p8rsf	711	41	;	;	:
cord-269011-230p8rsf	711	42	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	711	43	et	et	NNP
cord-269011-230p8rsf	711	44	al	al	NNP
cord-269011-230p8rsf	711	45	.	.	NNP
cord-269011-230p8rsf	711	46	,	,	,
cord-269011-230p8rsf	711	47	1995	1995	CD
cord-269011-230p8rsf	711	48	)	)	-RRB-
cord-269011-230p8rsf	711	49	.	.	.
cord-269011-230p8rsf	712	1	Complexes	complex	NNS
cord-269011-230p8rsf	712	2	of	of	IN
cord-269011-230p8rsf	712	3	the	the	DT
cord-269011-230p8rsf	712	4	proteins	protein	NNS
cord-269011-230p8rsf	712	5	were	be	VBD
cord-269011-230p8rsf	712	6	shown	show	VBN
cord-269011-230p8rsf	712	7	by	by	IN
cord-269011-230p8rsf	712	8	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	712	9	and	and	CC
cord-269011-230p8rsf	712	10	cosedimentation	cosedimentation	NN
cord-269011-230p8rsf	712	11	analyses	analysis	NNS
cord-269011-230p8rsf	712	12	as	as	RB
cord-269011-230p8rsf	712	13	well	well	RB
cord-269011-230p8rsf	712	14	as	as	IN
cord-269011-230p8rsf	712	15	by	by	IN
cord-269011-230p8rsf	712	16	immunofluorescence	immunofluorescence	NN
cord-269011-230p8rsf	712	17	studies	study	NNS
cord-269011-230p8rsf	712	18	in	in	IN
cord-269011-230p8rsf	712	19	which	which	WDT
cord-269011-230p8rsf	712	20	the	the	DT
cord-269011-230p8rsf	712	21	intracellular	intracellular	JJ
cord-269011-230p8rsf	712	22	transport	transport	NN
cord-269011-230p8rsf	712	23	of	of	IN
cord-269011-230p8rsf	712	24	S	s	NN
cord-269011-230p8rsf	713	1	and	and	CC
cord-269011-230p8rsf	713	2	HE	he	PRP
cord-269011-230p8rsf	713	3	proteins	protein	VBZ
cord-269011-230p8rsf	713	4	to	to	IN
cord-269011-230p8rsf	713	5	the	the	DT
cord-269011-230p8rsf	713	6	plasma	plasma	NN
cord-269011-230p8rsf	713	7	membrane	membrane	NN
cord-269011-230p8rsf	713	8	was	be	VBD
cord-269011-230p8rsf	713	9	found	find	VBN
cord-269011-230p8rsf	713	10	to	to	TO
cord-269011-230p8rsf	713	11	be	be	VB
cord-269011-230p8rsf	713	12	inhibited	inhibit	VBN
cord-269011-230p8rsf	713	13	by	by	IN
cord-269011-230p8rsf	713	14	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	713	15	M	M	NNP
cord-269011-230p8rsf	713	16	protein	protein	NN
cord-269011-230p8rsf	713	17	,	,	,
cord-269011-230p8rsf	713	18	the	the	DT
cord-269011-230p8rsf	713	19	proteins	protein	NNS
cord-269011-230p8rsf	713	20	being	be	VBG
cord-269011-230p8rsf	713	21	retained	retain	VBN
cord-269011-230p8rsf	713	22	in	in	IN
cord-269011-230p8rsf	713	23	the	the	DT
cord-269011-230p8rsf	713	24	Golgi	Golgi	NNP
cord-269011-230p8rsf	713	25	apparatus	apparatus	NN
cord-269011-230p8rsf	713	26	,	,	,
cord-269011-230p8rsf	713	27	the	the	DT
cord-269011-230p8rsf	713	28	natural	natural	JJ
cord-269011-230p8rsf	713	29	residence	residence	NN
cord-269011-230p8rsf	713	30	of	of	IN
cord-269011-230p8rsf	713	31	the	the	DT
cord-269011-230p8rsf	713	32	M	M	NNP
cord-269011-230p8rsf	713	33	protein	protein	NN
cord-269011-230p8rsf	713	34	.	.	.
cord-269011-230p8rsf	714	1	The	the	DT
cord-269011-230p8rsf	714	2	kinetics	kinetic	NNS
cord-269011-230p8rsf	714	3	with	with	IN
cord-269011-230p8rsf	714	4	which	which	WDT
cord-269011-230p8rsf	714	5	the	the	DT
cord-269011-230p8rsf	714	6	proteins	protein	NNS
cord-269011-230p8rsf	714	7	engage	engage	VBP
cord-269011-230p8rsf	714	8	in	in	IN
cord-269011-230p8rsf	714	9	heteromeric	heteromeric	NNP
cord-269011-230p8rsf	714	10	complex	complex	JJ
cord-269011-230p8rsf	714	11	formation	formation	NN
cord-269011-230p8rsf	714	12	appeared	appear	VBD
cord-269011-230p8rsf	714	13	to	to	TO
cord-269011-230p8rsf	714	14	be	be	VB
cord-269011-230p8rsf	714	15	different	different	JJ
cord-269011-230p8rsf	714	16	for	for	IN
cord-269011-230p8rsf	714	17	the	the	DT
cord-269011-230p8rsf	714	18	different	different	JJ
cord-269011-230p8rsf	714	19	proteins	protein	NNS
cord-269011-230p8rsf	714	20	.	.	.
cord-269011-230p8rsf	715	1	This	this	DT
cord-269011-230p8rsf	715	2	effect	effect	NN
cord-269011-230p8rsf	715	3	is	be	VBZ
cord-269011-230p8rsf	715	4	due	due	JJ
cord-269011-230p8rsf	715	5	to	to	IN
cord-269011-230p8rsf	715	6	their	-PRON-	PRP$
cord-269011-230p8rsf	715	7	different	different	JJ
cord-269011-230p8rsf	715	8	rates	rate	NNS
cord-269011-230p8rsf	715	9	of	of	IN
cord-269011-230p8rsf	715	10	folding	folding	NN
cord-269011-230p8rsf	715	11	and	and	CC
cord-269011-230p8rsf	715	12	oligomerization	oligomerization	NN
cord-269011-230p8rsf	715	13	.	.	.
cord-269011-230p8rsf	716	1	For	for	IN
cord-269011-230p8rsf	716	2	the	the	DT
cord-269011-230p8rsf	716	3	S	S	NNP
cord-269011-230p8rsf	716	4	protein	protein	NN
cord-269011-230p8rsf	716	5	these	these	DT
cord-269011-230p8rsf	716	6	rates	rate	NNS
cord-269011-230p8rsf	716	7	are	be	VBP
cord-269011-230p8rsf	716	8	low	low	JJ
cord-269011-230p8rsf	716	9	,	,	,
cord-269011-230p8rsf	716	10	involving	involve	VBG
cord-269011-230p8rsf	716	11	the	the	DT
cord-269011-230p8rsf	716	12	formation	formation	NN
cord-269011-230p8rsf	716	13	of	of	IN
cord-269011-230p8rsf	716	14	multiple	multiple	JJ
cord-269011-230p8rsf	716	15	intramolecular	intramolecular	JJ
cord-269011-230p8rsf	716	16	disulfide	disulfide	JJ
cord-269011-230p8rsf	716	17	bonds	bond	NNS
cord-269011-230p8rsf	716	18	and	and	CC
cord-269011-230p8rsf	716	19	the	the	DT
cord-269011-230p8rsf	716	20	addition	addition	NN
cord-269011-230p8rsf	716	21	of	of	IN
cord-269011-230p8rsf	716	22	numerous	numerous	JJ
cord-269011-230p8rsf	716	23	oligosaccharide	oligosaccharide	NN
cord-269011-230p8rsf	716	24	side	side	NN
cord-269011-230p8rsf	716	25	chains	chain	NNS
cord-269011-230p8rsf	716	26	(	(	-LRB-
cord-269011-230p8rsf	716	27	Delmas	Delmas	NNP
cord-269011-230p8rsf	716	28	and	and	CC
cord-269011-230p8rsf	716	29	Laude	Laude	NNP
cord-269011-230p8rsf	716	30	,	,	,
cord-269011-230p8rsf	716	31	1990	1990	CD
cord-269011-230p8rsf	716	32	;	;	:
cord-269011-230p8rsf	717	1	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	717	2	et	et	NNP
cord-269011-230p8rsf	717	3	al	al	NNP
cord-269011-230p8rsf	717	4	.	.	.
cord-269011-230p8rsf	718	1	,	,	,
cord-269011-230p8rsf	718	2	1993a	1993a	CD
cord-269011-230p8rsf	718	3	;	;	:
cord-269011-230p8rsf	718	4	Vennema	Vennema	NNP
cord-269011-230p8rsf	718	5	et	et	FW
cord-269011-230p8rsf	718	6	al	al	NNP
cord-269011-230p8rsf	718	7	.	.	.
cord-269011-230p8rsf	719	1	,	,	,
cord-269011-230p8rsf	719	2	1990a	1990a	CD
cord-269011-230p8rsf	719	3	,	,	,
cord-269011-230p8rsf	719	4	b	b	LS
cord-269011-230p8rsf	719	5	)	)	-RRB-
cord-269011-230p8rsf	719	6	.	.	.
cord-269011-230p8rsf	720	1	In	in	IN
cord-269011-230p8rsf	720	2	contrast	contrast	NN
cord-269011-230p8rsf	720	3	,	,	,
cord-269011-230p8rsf	720	4	folding	folding	NN
cord-269011-230p8rsf	720	5	of	of	IN
cord-269011-230p8rsf	720	6	the	the	DT
cord-269011-230p8rsf	720	7	MHV	MHV	NNP
cord-269011-230p8rsf	720	8	and	and	CC
cord-269011-230p8rsf	720	9	BCoV	BCoV	NNP
cord-269011-230p8rsf	720	10	M	M	NNP
cord-269011-230p8rsf	720	11	proteins	protein	NNS
cord-269011-230p8rsf	720	12	is	be	VBZ
cord-269011-230p8rsf	720	13	independent	independent	JJ
cord-269011-230p8rsf	720	14	of	of	IN
cord-269011-230p8rsf	720	15	disulfide	disulfide	JJ
cord-269011-230p8rsf	720	16	bonds	bond	NNS
cord-269011-230p8rsf	720	17	and	and	CC
cord-269011-230p8rsf	720	18	glycosylation	glycosylation	NN
cord-269011-230p8rsf	720	19	,	,	,
cord-269011-230p8rsf	720	20	as	as	IN
cord-269011-230p8rsf	720	21	a	a	DT
cord-269011-230p8rsf	720	22	result	result	NN
cord-269011-230p8rsf	720	23	of	of	IN
cord-269011-230p8rsf	720	24	which	which	WDT
cord-269011-230p8rsf	720	25	they	-PRON-	PRP
cord-269011-230p8rsf	720	26	are	be	VBP
cord-269011-230p8rsf	720	27	,	,	,
cord-269011-230p8rsf	720	28	for	for	IN
cord-269011-230p8rsf	720	29	instance	instance	NN
cord-269011-230p8rsf	720	30	,	,	,
cord-269011-230p8rsf	720	31	swiftly	swiftly	RB
cord-269011-230p8rsf	720	32	transported	transport	VBD
cord-269011-230p8rsf	720	33	out	out	IN
cord-269011-230p8rsf	720	34	of	of	IN
cord-269011-230p8rsf	720	35	the	the	DT
cord-269011-230p8rsf	720	36	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	720	37	reticulum	reticulum	NN
cord-269011-230p8rsf	720	38	(	(	-LRB-
cord-269011-230p8rsf	720	39	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	720	40	et	et	NNP
cord-269011-230p8rsf	720	41	al	al	NNP
cord-269011-230p8rsf	720	42	.	.	NNP
cord-269011-230p8rsf	720	43	,	,	,
cord-269011-230p8rsf	720	44	1993a	1993a	CD
cord-269011-230p8rsf	720	45	)	)	-RRB-
cord-269011-230p8rsf	720	46	.	.	.
cord-269011-230p8rsf	721	1	As	as	IN
cord-269011-230p8rsf	721	2	a	a	DT
cord-269011-230p8rsf	721	3	consequence	consequence	NN
cord-269011-230p8rsf	721	4	,	,	,
cord-269011-230p8rsf	721	5	M	M	NNP
cord-269011-230p8rsf	721	6	molecules	molecule	NNS
cord-269011-230p8rsf	721	7	enter	enter	VBP
cord-269011-230p8rsf	721	8	into	into	IN
cord-269011-230p8rsf	721	9	M	M	NNP
cord-269011-230p8rsf	721	10	-	-	HYPH
cord-269011-230p8rsf	721	11	S	S	NNP
cord-269011-230p8rsf	721	12	and	and	CC
cord-269011-230p8rsf	721	13	M	M	NNP
cord-269011-230p8rsf	721	14	-	-	HYPH
cord-269011-230p8rsf	721	15	HE	HE	NNP
cord-269011-230p8rsf	721	16	complexes	complex	NNS
cord-269011-230p8rsf	721	17	immediately	immediately	RB
cord-269011-230p8rsf	721	18	after	after	IN
cord-269011-230p8rsf	721	19	their	-PRON-	PRP$
cord-269011-230p8rsf	721	20	synthesis	synthesis	NN
cord-269011-230p8rsf	721	21	whereas	whereas	IN
cord-269011-230p8rsf	721	22	for	for	IN
cord-269011-230p8rsf	721	23	newly	newly	RB
cord-269011-230p8rsf	721	24	synthesized	synthesize	VBN
cord-269011-230p8rsf	721	25	S	s	NN
cord-269011-230p8rsf	722	1	and	and	CC
cord-269011-230p8rsf	722	2	HE	he	PRP
cord-269011-230p8rsf	722	3	molecules	molecule	VBZ
cord-269011-230p8rsf	723	1	it	-PRON-	PRP
cord-269011-230p8rsf	723	2	took	take	VBD
cord-269011-230p8rsf	723	3	15	15	CD
cord-269011-230p8rsf	723	4	-	-	SYM
cord-269011-230p8rsf	723	5	30	30	CD
cord-269011-230p8rsf	723	6	min	min	NN
cord-269011-230p8rsf	723	7	before	before	IN
cord-269011-230p8rsf	723	8	they	-PRON-	PRP
cord-269011-230p8rsf	723	9	started	start	VBD
cord-269011-230p8rsf	723	10	to	to	TO
cord-269011-230p8rsf	723	11	appear	appear	VB
cord-269011-230p8rsf	723	12	in	in	IN
cord-269011-230p8rsf	723	13	these	these	DT
cord-269011-230p8rsf	723	14	heterocomplexes	heterocomplexe	NNS
cord-269011-230p8rsf	723	15	(	(	-LRB-
cord-269011-230p8rsf	723	16	Nguyen	Nguyen	NNP
cord-269011-230p8rsf	723	17	and	and	CC
cord-269011-230p8rsf	723	18	Hogue	Hogue	NNP
cord-269011-230p8rsf	723	19	,	,	,
cord-269011-230p8rsf	723	20	1997	1997	CD
cord-269011-230p8rsf	723	21	;	;	.
cord-269011-230p8rsf	724	1	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	724	2	et	et	NNP
cord-269011-230p8rsf	724	3	al	al	NNP
cord-269011-230p8rsf	724	4	.	.	NNP
cord-269011-230p8rsf	724	5	,	,	,
cord-269011-230p8rsf	724	6	1995	1995	CD
cord-269011-230p8rsf	724	7	)	)	-RRB-
cord-269011-230p8rsf	724	8	.	.	.
cord-269011-230p8rsf	725	1	The	the	DT
cord-269011-230p8rsf	725	2	importance	importance	NN
cord-269011-230p8rsf	725	3	of	of	IN
cord-269011-230p8rsf	725	4	folding	fold	VBG
cord-269011-230p8rsf	725	5	as	as	IN
cord-269011-230p8rsf	725	6	a	a	DT
cord-269011-230p8rsf	725	7	major	major	JJ
cord-269011-230p8rsf	725	8	rate	rate	NN
cord-269011-230p8rsf	725	9	-	-	HYPH
cord-269011-230p8rsf	725	10	limiting	limit	VBG
cord-269011-230p8rsf	725	11	step	step	NN
cord-269011-230p8rsf	725	12	was	be	VBD
cord-269011-230p8rsf	725	13	illustrated	illustrate	VBN
cord-269011-230p8rsf	725	14	by	by	IN
cord-269011-230p8rsf	725	15	the	the	DT
cord-269011-230p8rsf	725	16	inability	inability	NN
cord-269011-230p8rsf	725	17	of	of	IN
cord-269011-230p8rsf	725	18	the	the	DT
cord-269011-230p8rsf	725	19	S	S	NNP
cord-269011-230p8rsf	725	20	protein	protein	NN
cord-269011-230p8rsf	725	21	to	to	TO
cord-269011-230p8rsf	725	22	interact	interact	VB
cord-269011-230p8rsf	725	23	with	with	IN
cord-269011-230p8rsf	725	24	M	M	NNP
cord-269011-230p8rsf	725	25	protein	protein	NN
cord-269011-230p8rsf	725	26	when	when	WRB
cord-269011-230p8rsf	725	27	its	-PRON-	PRP$
cord-269011-230p8rsf	725	28	folding	folding	NN
cord-269011-230p8rsf	725	29	had	have	VBD
cord-269011-230p8rsf	725	30	been	be	VBN
cord-269011-230p8rsf	725	31	inhibited	inhibit	VBN
cord-269011-230p8rsf	725	32	by	by	IN
cord-269011-230p8rsf	725	33	in	in	IN
cord-269011-230p8rsf	725	34	vivo	vivo	NN
cord-269011-230p8rsf	725	35	reduction	reduction	NN
cord-269011-230p8rsf	725	36	;	;	:
cord-269011-230p8rsf	725	37	only	only	RB
cord-269011-230p8rsf	725	38	completely	completely	RB
cord-269011-230p8rsf	725	39	oxidized	oxidize	VBN
cord-269011-230p8rsf	725	40	S	s	NN
cord-269011-230p8rsf	725	41	molecules	molecule	NNS
cord-269011-230p8rsf	725	42	were	be	VBD
cord-269011-230p8rsf	725	43	association	association	NN
cord-269011-230p8rsf	725	44	competent	competent	JJ
cord-269011-230p8rsf	725	45	(	(	-LRB-
cord-269011-230p8rsf	725	46	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	725	47	et	et	NNP
cord-269011-230p8rsf	725	48	al	al	NNP
cord-269011-230p8rsf	725	49	.	.	NNP
cord-269011-230p8rsf	725	50	,	,	,
cord-269011-230p8rsf	725	51	1993a	1993a	CD
cord-269011-230p8rsf	725	52	.	.	.
cord-269011-230p8rsf	726	1	Whether	whether	IN
cord-269011-230p8rsf	726	2	the	the	DT
cord-269011-230p8rsf	726	3	M	M	NNP
cord-269011-230p8rsf	726	4	protein	protein	NN
cord-269011-230p8rsf	726	5	interacts	interact	VBZ
cord-269011-230p8rsf	726	6	with	with	IN
cord-269011-230p8rsf	726	7	S	s	NN
cord-269011-230p8rsf	727	1	and	and	CC
cord-269011-230p8rsf	727	2	HE	he	PRP
cord-269011-230p8rsf	727	3	proteins	protein	VBZ
cord-269011-230p8rsf	727	4	while	while	IN
cord-269011-230p8rsf	727	5	they	-PRON-	PRP
cord-269011-230p8rsf	727	6	are	be	VBP
cord-269011-230p8rsf	727	7	still	still	RB
cord-269011-230p8rsf	727	8	in	in	IN
cord-269011-230p8rsf	727	9	their	-PRON-	PRP$
cord-269011-230p8rsf	727	10	monomeric	monomeric	JJ
cord-269011-230p8rsf	727	11	form	form	NN
cord-269011-230p8rsf	727	12	or	or	CC
cord-269011-230p8rsf	727	13	only	only	RB
cord-269011-230p8rsf	727	14	after	after	IN
cord-269011-230p8rsf	727	15	their	-PRON-	PRP$
cord-269011-230p8rsf	727	16	oligomerization	oligomerization	NN
cord-269011-230p8rsf	727	17	remains	remain	VBZ
cord-269011-230p8rsf	727	18	to	to	TO
cord-269011-230p8rsf	727	19	be	be	VB
cord-269011-230p8rsf	727	20	elucidated	elucidate	VBN
cord-269011-230p8rsf	727	21	.	.	.
cord-269011-230p8rsf	728	1	It	-PRON-	PRP
cord-269011-230p8rsf	728	2	is	be	VBZ
cord-269011-230p8rsf	728	3	,	,	,
cord-269011-230p8rsf	728	4	however	however	RB
cord-269011-230p8rsf	728	5	,	,	,
cord-269011-230p8rsf	728	6	clear	clear	JJ
cord-269011-230p8rsf	728	7	that	that	IN
cord-269011-230p8rsf	728	8	the	the	DT
cord-269011-230p8rsf	728	9	proteins	protein	NNS
cord-269011-230p8rsf	728	10	engage	engage	VBP
cord-269011-230p8rsf	728	11	in	in	IN
cord-269011-230p8rsf	728	12	interaction	interaction	NN
cord-269011-230p8rsf	728	13	with	with	IN
cord-269011-230p8rsf	728	14	each	each	DT
cord-269011-230p8rsf	728	15	other	other	JJ
cord-269011-230p8rsf	728	16	in	in	IN
cord-269011-230p8rsf	728	17	early	early	JJ
cord-269011-230p8rsf	728	18	compartments	compartment	NNS
cord-269011-230p8rsf	728	19	,	,	,
cord-269011-230p8rsf	728	20	most	most	RBS
cord-269011-230p8rsf	728	21	likely	likely	RB
cord-269011-230p8rsf	728	22	the	the	DT
cord-269011-230p8rsf	728	23	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	728	24	reticulum	reticulum	NN
cord-269011-230p8rsf	728	25	,	,	,
cord-269011-230p8rsf	728	26	as	as	IN
cord-269011-230p8rsf	728	27	judged	judge	VBN
cord-269011-230p8rsf	728	28	from	from	IN
cord-269011-230p8rsf	728	29	the	the	DT
cord-269011-230p8rsf	728	30	oligosaccharide	oligosaccharide	NN
cord-269011-230p8rsf	728	31	maturation	maturation	NN
cord-269011-230p8rsf	728	32	states	state	NNS
cord-269011-230p8rsf	728	33	of	of	IN
cord-269011-230p8rsf	728	34	freshly	freshly	RB
cord-269011-230p8rsf	728	35	formed	form	VBN
cord-269011-230p8rsf	728	36	protein	protein	NN
cord-269011-230p8rsf	728	37	complexes	complex	NNS
cord-269011-230p8rsf	728	38	(	(	-LRB-
cord-269011-230p8rsf	728	39	de	de	FW
cord-269011-230p8rsf	728	40	Haan	Haan	NNP
cord-269011-230p8rsf	728	41	et	et	FW
cord-269011-230p8rsf	728	42	al	al	NNP
cord-269011-230p8rsf	728	43	.	.	NNP
cord-269011-230p8rsf	728	44	,	,	,
cord-269011-230p8rsf	728	45	1999	1999	CD
cord-269011-230p8rsf	728	46	;	;	:
cord-269011-230p8rsf	728	47	Nguyen	Nguyen	NNP
cord-269011-230p8rsf	728	48	and	and	CC
cord-269011-230p8rsf	728	49	Hogue	Hogue	NNP
cord-269011-230p8rsf	728	50	,	,	,
cord-269011-230p8rsf	728	51	1997	1997	CD
cord-269011-230p8rsf	728	52	;	;	.
cord-269011-230p8rsf	729	1	Opstelten	Opstelten	NNP
cord-269011-230p8rsf	729	2	et	et	NNP
cord-269011-230p8rsf	729	3	al	al	NNP
cord-269011-230p8rsf	729	4	.	.	NNP
cord-269011-230p8rsf	729	5	,	,	,
cord-269011-230p8rsf	729	6	1995	1995	CD
cord-269011-230p8rsf	729	7	)	)	-RRB-
cord-269011-230p8rsf	729	8	.	.	.
cord-269011-230p8rsf	730	1	Only	only	RB
cord-269011-230p8rsf	730	2	dimers	dimer	NNS
cord-269011-230p8rsf	730	3	of	of	IN
cord-269011-230p8rsf	730	4	HE	he	PRP
cord-269011-230p8rsf	730	5	were	be	VBD
cord-269011-230p8rsf	730	6	associated	associate	VBN
cord-269011-230p8rsf	730	7	with	with	IN
cord-269011-230p8rsf	730	8	HE	HE	NNP
cord-269011-230p8rsf	730	9	-	-	HYPH
cord-269011-230p8rsf	730	10	M	M	NNP
cord-269011-230p8rsf	730	11	-	-	HYPH
cord-269011-230p8rsf	730	12	S	S	NNP
cord-269011-230p8rsf	730	13	complexes	complex	NNS
cord-269011-230p8rsf	730	14	that	that	WDT
cord-269011-230p8rsf	730	15	were	be	VBD
cord-269011-230p8rsf	730	16	observed	observe	VBN
cord-269011-230p8rsf	730	17	in	in	IN
cord-269011-230p8rsf	730	18	BCoV	BCoV	NNP
cord-269011-230p8rsf	730	19	-	-	HYPH
cord-269011-230p8rsf	730	20	infected	infect	VBN
cord-269011-230p8rsf	730	21	cells	cell	NNS
cord-269011-230p8rsf	730	22	;	;	:
cord-269011-230p8rsf	730	23	because	because	IN
cord-269011-230p8rsf	730	24	the	the	DT
cord-269011-230p8rsf	730	25	appearance	appearance	NN
cord-269011-230p8rsf	730	26	of	of	IN
cord-269011-230p8rsf	730	27	HE	he	PRP
cord-269011-230p8rsf	730	28	in	in	IN
cord-269011-230p8rsf	730	29	these	these	DT
cord-269011-230p8rsf	730	30	complexes	complex	NNS
cord-269011-230p8rsf	730	31	correlated	correlate	VBN
cord-269011-230p8rsf	730	32	with	with	IN
cord-269011-230p8rsf	730	33	the	the	DT
cord-269011-230p8rsf	730	34	kinetics	kinetic	NNS
cord-269011-230p8rsf	730	35	of	of	IN
cord-269011-230p8rsf	730	36	HE	HE	NNP
cord-269011-230p8rsf	730	37	dimerization	dimerization	NN
cord-269011-230p8rsf	730	38	it	-PRON-	PRP
cord-269011-230p8rsf	730	39	was	be	VBD
cord-269011-230p8rsf	730	40	concluded	conclude	VBN
cord-269011-230p8rsf	730	41	that	that	IN
cord-269011-230p8rsf	730	42	proper	proper	JJ
cord-269011-230p8rsf	730	43	oligomerization	oligomerization	NN
cord-269011-230p8rsf	730	44	is	be	VBZ
cord-269011-230p8rsf	730	45	most	most	RBS
cord-269011-230p8rsf	730	46	likely	likely	RB
cord-269011-230p8rsf	730	47	a	a	DT
cord-269011-230p8rsf	730	48	requirement	requirement	NN
cord-269011-230p8rsf	730	49	for	for	IN
cord-269011-230p8rsf	730	50	its	-PRON-	PRP$
cord-269011-230p8rsf	730	51	association	association	NN
cord-269011-230p8rsf	730	52	(	(	-LRB-
cord-269011-230p8rsf	730	53	Nguyen	Nguyen	NNP
cord-269011-230p8rsf	730	54	and	and	CC
cord-269011-230p8rsf	730	55	Hogue	Hogue	NNP
cord-269011-230p8rsf	730	56	,	,	,
cord-269011-230p8rsf	730	57	1997	1997	CD
cord-269011-230p8rsf	730	58	)	)	-RRB-
cord-269011-230p8rsf	730	59	.	.	.
cord-269011-230p8rsf	731	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	731	2	,	,	,
cord-269011-230p8rsf	731	3	such	such	JJ
cord-269011-230p8rsf	731	4	heterotrimeric	heterotrimeric	JJ
cord-269011-230p8rsf	731	5	complexes	complex	NNS
cord-269011-230p8rsf	731	6	were	be	VBD
cord-269011-230p8rsf	731	7	not	not	RB
cord-269011-230p8rsf	731	8	observed	observe	VBN
cord-269011-230p8rsf	731	9	on	on	IN
cord-269011-230p8rsf	731	10	coexpression	coexpression	NN
cord-269011-230p8rsf	731	11	of	of	IN
cord-269011-230p8rsf	731	12	the	the	DT
cord-269011-230p8rsf	731	13	three	three	CD
cord-269011-230p8rsf	731	14	proteins	protein	NNS
cord-269011-230p8rsf	731	15	in	in	IN
cord-269011-230p8rsf	731	16	cells	cell	NNS
cord-269011-230p8rsf	731	17	.	.	.
cord-269011-230p8rsf	732	1	Under	under	IN
cord-269011-230p8rsf	732	2	these	these	DT
cord-269011-230p8rsf	732	3	conditions	condition	NNS
cord-269011-230p8rsf	732	4	only	only	RB
cord-269011-230p8rsf	732	5	the	the	DT
cord-269011-230p8rsf	732	6	heterodimeric	heterodimeric	NNP
cord-269011-230p8rsf	732	7	M	M	NNP
cord-269011-230p8rsf	732	8	-	-	HYPH
cord-269011-230p8rsf	732	9	S	S	NNP
cord-269011-230p8rsf	732	10	and	and	CC
cord-269011-230p8rsf	732	11	M	M	NNP
cord-269011-230p8rsf	732	12	-	-	HYPH
cord-269011-230p8rsf	732	13	HE	HE	NNP
cord-269011-230p8rsf	732	14	associations	association	NNS
cord-269011-230p8rsf	732	15	were	be	VBD
cord-269011-230p8rsf	732	16	detected	detect	VBN
cord-269011-230p8rsf	732	17	.	.	.
cord-269011-230p8rsf	733	1	The	the	DT
cord-269011-230p8rsf	733	2	structural	structural	JJ
cord-269011-230p8rsf	733	3	domains	domain	NNS
cord-269011-230p8rsf	733	4	of	of	IN
cord-269011-230p8rsf	733	5	M	M	NNP
cord-269011-230p8rsf	733	6	and	and	CC
cord-269011-230p8rsf	733	7	S	S	NNP
cord-269011-230p8rsf	733	8	proteins	protein	NNS
cord-269011-230p8rsf	733	9	that	that	WDT
cord-269011-230p8rsf	733	10	are	be	VBP
cord-269011-230p8rsf	733	11	involved	involve	VBN
cord-269011-230p8rsf	733	12	in	in	IN
cord-269011-230p8rsf	733	13	the	the	DT
cord-269011-230p8rsf	733	14	formation	formation	NN
cord-269011-230p8rsf	733	15	and	and	CC
cord-269011-230p8rsf	733	16	stabilization	stabilization	NN
cord-269011-230p8rsf	733	17	of	of	IN
cord-269011-230p8rsf	733	18	their	-PRON-	PRP$
cord-269011-230p8rsf	733	19	complex	complex	JJ
cord-269011-230p8rsf	733	20	have	have	VBP
cord-269011-230p8rsf	733	21	been	be	VBN
cord-269011-230p8rsf	733	22	identified	identify	VBN
cord-269011-230p8rsf	733	23	.	.	.
cord-269011-230p8rsf	734	1	Using	use	VBG
cord-269011-230p8rsf	734	2	the	the	DT
cord-269011-230p8rsf	734	3	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	734	4	and	and	CC
cord-269011-230p8rsf	734	5	colocalization	colocalization	NN
cord-269011-230p8rsf	734	6	assays	assay	NNS
cord-269011-230p8rsf	734	7	referred	refer	VBD
cord-269011-230p8rsf	734	8	to	to	IN
cord-269011-230p8rsf	734	9	previously	previously	RB
cord-269011-230p8rsf	734	10	,	,	,
cord-269011-230p8rsf	734	11	the	the	DT
cord-269011-230p8rsf	734	12	essential	essential	JJ
cord-269011-230p8rsf	734	13	domains	domain	NNS
cord-269011-230p8rsf	734	14	in	in	IN
cord-269011-230p8rsf	734	15	the	the	DT
cord-269011-230p8rsf	734	16	MHV	MHV	NNP
cord-269011-230p8rsf	734	17	M	M	NNP
cord-269011-230p8rsf	734	18	protein	protein	NN
cord-269011-230p8rsf	734	19	were	be	VBD
cord-269011-230p8rsf	734	20	mapped	map	VBN
cord-269011-230p8rsf	734	21	by	by	IN
cord-269011-230p8rsf	734	22	a	a	DT
cord-269011-230p8rsf	734	23	mutag	mutag	NNP
cord-269011-230p8rsf	734	24	enetic	enetic	JJ
cord-269011-230p8rsf	734	25	appro	appro	NNP
cord-269011-230p8rsf	734	26	ach	ach	NNP
cord-269011-230p8rsf	734	27	(	(	-LRB-
cord-269011-230p8rsf	734	28	de	de	NNP
cord-269011-230p8rsf	734	29	Ha	Ha	NNP
cord-269011-230p8rsf	734	30	an	an	DT
cord-269011-230p8rsf	735	1	et	et	NNP
cord-269011-230p8rsf	735	2	al	al	NNP
cord-269011-230p8rsf	735	3	.	.	NNP
cord-269011-230p8rsf	735	4	,	,	,
cord-269011-230p8rsf	735	5	1999	1999	CD
cord-269011-230p8rsf	735	6	)	)	-RRB-
cord-269011-230p8rsf	735	7	.	.	.
cord-269011-230p8rsf	736	1	It	-PRON-	PRP
cord-269011-230p8rsf	736	2	appear	appear	VBP
cord-269011-230p8rsf	736	3	ed	ed	IN
cord-269011-230p8rsf	736	4	tha	tha	NNP
cord-269011-230p8rsf	736	5	t	t	NNP
cord-269011-230p8rsf	736	6	M	M	NNP
cord-269011-230p8rsf	736	7	-	-	HYPH
cord-269011-230p8rsf	736	8	S	S	NNP
cord-269011-230p8rsf	736	9	complex	complex	JJ
cord-269011-230p8rsf	736	10	formation	formation	NN
cord-269011-230p8rsf	736	11	was	be	VBD
cord-269011-230p8rsf	736	12	sensitive	sensitive	JJ
cord-269011-230p8rsf	736	13	to	to	IN
cord-269011-230p8rsf	736	14	changes	change	NNS
cord-269011-230p8rsf	736	15	in	in	IN
cord-269011-230p8rsf	736	16	all	all	DT
cord-269011-230p8rsf	736	17	membrane	membrane	NN
cord-269011-230p8rsf	736	18	-	-	HYPH
cord-269011-230p8rsf	736	19	associated	associate	VBN
cord-269011-230p8rsf	736	20	parts	part	NNS
cord-269011-230p8rsf	736	21	of	of	IN
cord-269011-230p8rsf	736	22	the	the	DT
cord-269011-230p8rsf	736	23	M	M	NNP
cord-269011-230p8rsf	736	24	molecule	molecule	NN
cord-269011-230p8rsf	736	25	.	.	.
cord-269011-230p8rsf	737	1	Interactions	interaction	NNS
cord-269011-230p8rsf	737	2	between	between	IN
cord-269011-230p8rsf	737	3	M	M	NNP
cord-269011-230p8rsf	737	4	and	and	CC
cord-269011-230p8rsf	737	5	S	S	NNP
cord-269011-230p8rsf	737	6	proteins	protein	NNS
cord-269011-230p8rsf	737	7	were	be	VBD
cord-269011-230p8rsf	737	8	found	find	VBN
cord-269011-230p8rsf	737	9	to	to	TO
cord-269011-230p8rsf	737	10	occur	occur	VB
cord-269011-230p8rsf	737	11	at	at	IN
cord-269011-230p8rsf	737	12	the	the	DT
cord-269011-230p8rsf	737	13	level	level	NN
cord-269011-230p8rsf	737	14	of	of	IN
cord-269011-230p8rsf	737	15	the	the	DT
cord-269011-230p8rsf	737	16	transmembrane	transmembrane	NN
cord-269011-230p8rsf	737	17	domains	domain	NNS
cord-269011-230p8rsf	737	18	and	and	CC
cord-269011-230p8rsf	737	19	of	of	IN
cord-269011-230p8rsf	737	20	the	the	DT
cord-269011-230p8rsf	737	21	amphipathic	amphipathic	NNP
cord-269011-230p8rsf	737	22	domain	domain	NN
cord-269011-230p8rsf	737	23	,	,	,
cord-269011-230p8rsf	737	24	which	which	WDT
cord-269011-230p8rsf	737	25	is	be	VBZ
cord-269011-230p8rsf	737	26	located	locate	VBN
cord-269011-230p8rsf	737	27	on	on	IN
cord-269011-230p8rsf	737	28	the	the	DT
cord-269011-230p8rsf	737	29	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	737	30	face	face	NN
cord-269011-230p8rsf	737	31	of	of	IN
cord-269011-230p8rsf	737	32	cellular	cellular	JJ
cord-269011-230p8rsf	737	33	membranes	membrane	NNS
cord-269011-230p8rsf	737	34	.	.	.
cord-269011-230p8rsf	738	1	In	in	IN
cord-269011-230p8rsf	738	2	contrast	contrast	NN
cord-269011-230p8rsf	738	3	,	,	,
cord-269011-230p8rsf	738	4	neither	neither	CC
cord-269011-230p8rsf	738	5	the	the	DT
cord-269011-230p8rsf	738	6	lumenally	lumenally	RB
cord-269011-230p8rsf	738	7	exposed	expose	VBN
cord-269011-230p8rsf	738	8	amino	amino	NN
cord-269011-230p8rsf	738	9	terminus	terminus	NN
cord-269011-230p8rsf	738	10	nor	nor	CC
cord-269011-230p8rsf	738	11	the	the	DT
cord-269011-230p8rsf	738	12	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	738	13	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	738	14	tail	tail	NN
cord-269011-230p8rsf	738	15	of	of	IN
cord-269011-230p8rsf	738	16	the	the	DT
cord-269011-230p8rsf	738	17	M	M	NNP
cord-269011-230p8rsf	738	18	protein	protein	NN
cord-269011-230p8rsf	738	19	was	be	VBD
cord-269011-230p8rsf	738	20	required	require	VBN
cord-269011-230p8rsf	738	21	;	;	:
cord-269011-230p8rsf	738	22	even	even	RB
cord-269011-230p8rsf	738	23	the	the	DT
cord-269011-230p8rsf	738	24	deletion	deletion	NN
cord-269011-230p8rsf	738	25	of	of	IN
cord-269011-230p8rsf	738	26	these	these	DT
cord-269011-230p8rsf	738	27	parts	part	NNS
cord-269011-230p8rsf	738	28	-	-	HYPH
cord-269011-230p8rsf	738	29	known	know	VBN
cord-269011-230p8rsf	738	30	to	to	TO
cord-269011-230p8rsf	738	31	abrogate	abrogate	VB
cord-269011-230p8rsf	738	32	the	the	DT
cord-269011-230p8rsf	738	33	ability	ability	NN
cord-269011-230p8rsf	738	34	of	of	IN
cord-269011-230p8rsf	738	35	the	the	DT
cord-269011-230p8rsf	738	36	protein	protein	NN
cord-269011-230p8rsf	738	37	to	to	TO
cord-269011-230p8rsf	738	38	form	form	VB
cord-269011-230p8rsf	738	39	VLPs	vlp	NNS
cord-269011-230p8rsf	738	40	-	-	:
cord-269011-230p8rsf	738	41	did	do	VBD
cord-269011-230p8rsf	738	42	not	not	RB
cord-269011-230p8rsf	738	43	prevent	prevent	VB
cord-269011-230p8rsf	738	44	association	association	NN
cord-269011-230p8rsf	738	45	with	with	IN
cord-269011-230p8rsf	738	46	the	the	DT
cord-269011-230p8rsf	738	47	S	S	NNP
cord-269011-230p8rsf	738	48	protein	protein	NN
cord-269011-230p8rsf	738	49	.	.	.
cord-269011-230p8rsf	739	1	Chimeric	Chimeric	NNP
cord-269011-230p8rsf	739	2	S	S	NNP
cord-269011-230p8rsf	739	3	proteins	protein	NNS
cord-269011-230p8rsf	739	4	were	be	VBD
cord-269011-230p8rsf	739	5	used	use	VBN
cord-269011-230p8rsf	739	6	to	to	TO
cord-269011-230p8rsf	739	7	show	show	VB
cord-269011-230p8rsf	739	8	that	that	IN
cord-269011-230p8rsf	739	9	the	the	DT
cord-269011-230p8rsf	739	10	large	large	JJ
cord-269011-230p8rsf	739	11	ectodomains	ectodomain	NNS
cord-269011-230p8rsf	739	12	of	of	IN
cord-269011-230p8rsf	739	13	the	the	DT
cord-269011-230p8rsf	739	14	spikes	spike	NNS
cord-269011-230p8rsf	739	15	are	be	VBP
cord-269011-230p8rsf	739	16	not	not	RB
cord-269011-230p8rsf	739	17	involved	involve	VBN
cord-269011-230p8rsf	739	18	in	in	IN
cord-269011-230p8rsf	739	19	interaction	interaction	NN
cord-269011-230p8rsf	739	20	with	with	IN
cord-269011-230p8rsf	739	21	M	M	NNP
cord-269011-230p8rsf	739	22	proteins	protein	NNS
cord-269011-230p8rsf	739	23	.	.	.
cord-269011-230p8rsf	740	1	Such	such	JJ
cord-269011-230p8rsf	740	2	chimeric	chimeric	JJ
cord-269011-230p8rsf	740	3	proteins	protein	NNS
cord-269011-230p8rsf	740	4	were	be	VBD
cord-269011-230p8rsf	740	5	constructed	construct	VBN
cord-269011-230p8rsf	740	6	from	from	IN
cord-269011-230p8rsf	740	7	the	the	DT
cord-269011-230p8rsf	740	8	MHV	MHV	NNP
cord-269011-230p8rsf	740	9	and	and	CC
cord-269011-230p8rsf	740	10	FIPV	FIPV	NNP
cord-269011-230p8rsf	740	11	S	S	NNP
cord-269011-230p8rsf	740	12	proteins	protein	NNS
cord-269011-230p8rsf	740	13	and	and	CC
cord-269011-230p8rsf	740	14	consisted	consist	VBD
cord-269011-230p8rsf	740	15	of	of	IN
cord-269011-230p8rsf	740	16	the	the	DT
cord-269011-230p8rsf	740	17	ecto	ecto	NN
cord-269011-230p8rsf	740	18	-	-	HYPH
cord-269011-230p8rsf	740	19	or	or	CC
cord-269011-230p8rsf	740	20	lumenal	lumenal	JJ
cord-269011-230p8rsf	740	21	domain	domain	NN
cord-269011-230p8rsf	740	22	from	from	IN
cord-269011-230p8rsf	740	23	the	the	DT
cord-269011-230p8rsf	740	24	one	one	CD
cord-269011-230p8rsf	740	25	and	and	CC
cord-269011-230p8rsf	740	26	the	the	DT
cord-269011-230p8rsf	740	27	transmembrane	transmembrane	NN
cord-269011-230p8rsf	740	28	plus	plus	CC
cord-269011-230p8rsf	740	29	endodomain	endodomain	NN
cord-269011-230p8rsf	740	30	from	from	IN
cord-269011-230p8rsf	740	31	the	the	DT
cord-269011-230p8rsf	740	32	other	other	JJ
cord-269011-230p8rsf	740	33	.	.	.
cord-269011-230p8rsf	741	1	These	these	DT
cord-269011-230p8rsf	741	2	proteins	protein	NNS
cord-269011-230p8rsf	741	3	,	,	,
cord-269011-230p8rsf	741	4	which	which	WDT
cord-269011-230p8rsf	741	5	seemed	seem	VBD
cord-269011-230p8rsf	741	6	biologically	biologically	RB
cord-269011-230p8rsf	741	7	fit	fit	JJ
cord-269011-230p8rsf	741	8	as	as	IN
cord-269011-230p8rsf	741	9	they	-PRON-	PRP
cord-269011-230p8rsf	741	10	were	be	VBD
cord-269011-230p8rsf	741	11	still	still	RB
cord-269011-230p8rsf	741	12	fusion	fusion	NN
cord-269011-230p8rsf	741	13	active	active	JJ
cord-269011-230p8rsf	741	14	,	,	,
cord-269011-230p8rsf	741	15	were	be	VBD
cord-269011-230p8rsf	741	16	initially	initially	RB
cord-269011-230p8rsf	741	17	tested	test	VBN
cord-269011-230p8rsf	741	18	in	in	IN
cord-269011-230p8rsf	741	19	coexpression	coexpression	NN
cord-269011-230p8rsf	741	20	studies	study	NNS
cord-269011-230p8rsf	741	21	with	with	IN
cord-269011-230p8rsf	741	22	the	the	DT
cord-269011-230p8rsf	741	23	M	M	NNP
cord-269011-230p8rsf	741	24	and	and	CC
cord-269011-230p8rsf	741	25	E	e	NN
cord-269011-230p8rsf	741	26	proteins	protein	NNS
cord-269011-230p8rsf	741	27	from	from	IN
cord-269011-230p8rsf	741	28	either	either	DT
cord-269011-230p8rsf	741	29	virus	virus	NN
cord-269011-230p8rsf	741	30	for	for	IN
cord-269011-230p8rsf	741	31	their	-PRON-	PRP$
cord-269011-230p8rsf	741	32	ability	ability	NN
cord-269011-230p8rsf	741	33	to	to	TO
cord-269011-230p8rsf	741	34	be	be	VB
cord-269011-230p8rsf	741	35	incorporated	incorporate	VBN
cord-269011-230p8rsf	741	36	into	into	IN
cord-269011-230p8rsf	741	37	VLPs	vlp	NNS
cord-269011-230p8rsf	741	38	.	.	.
cord-269011-230p8rsf	742	1	They	-PRON-	PRP
cord-269011-230p8rsf	742	2	were	be	VBD
cord-269011-230p8rsf	742	3	found	find	VBN
cord-269011-230p8rsf	742	4	to	to	TO
cord-269011-230p8rsf	742	5	assemble	assemble	VB
cord-269011-230p8rsf	742	6	only	only	RB
cord-269011-230p8rsf	742	7	into	into	IN
cord-269011-230p8rsf	742	8	viral	viral	JJ
cord-269011-230p8rsf	742	9	particles	particle	NNS
cord-269011-230p8rsf	742	10	of	of	IN
cord-269011-230p8rsf	742	11	the	the	DT
cord-269011-230p8rsf	742	12	species	specie	NNS
cord-269011-230p8rsf	742	13	from	from	IN
cord-269011-230p8rsf	742	14	which	which	WDT
cord-269011-230p8rsf	742	15	their	-PRON-	PRP$
cord-269011-230p8rsf	742	16	carboxy	carboxy	JJ
cord-269011-230p8rsf	742	17	-	-	HYPH
cord-269011-230p8rsf	742	18	terminal	terminal	NN
cord-269011-230p8rsf	742	19	domain	domain	NN
cord-269011-230p8rsf	742	20	originated	originate	VBD
cord-269011-230p8rsf	742	21	.	.	.
cord-269011-230p8rsf	743	1	The	the	DT
cord-269011-230p8rsf	743	2	chimeric	chimeric	JJ
cord-269011-230p8rsf	743	3	S	s	NN
cord-269011-230p8rsf	743	4	genes	gene	NNS
cord-269011-230p8rsf	743	5	were	be	VBD
cord-269011-230p8rsf	743	6	subsequently	subsequently	RB
cord-269011-230p8rsf	743	7	incorporated	incorporate	VBN
cord-269011-230p8rsf	743	8	into	into	IN
cord-269011-230p8rsf	743	9	the	the	DT
cord-269011-230p8rsf	743	10	proper	proper	JJ
cord-269011-230p8rsf	743	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	743	12	genomic	genomic	JJ
cord-269011-230p8rsf	743	13	background	background	NN
cord-269011-230p8rsf	743	14	,	,	,
cord-269011-230p8rsf	743	15	creating	create	VBG
cord-269011-230p8rsf	743	16	the	the	DT
cord-269011-230p8rsf	743	17	chimeric	chimeric	JJ
cord-269011-230p8rsf	743	18	viruses	virus	NNS
cord-269011-230p8rsf	743	19	fMHV	fmhv	RB
cord-269011-230p8rsf	743	20	and	and	CC
cord-269011-230p8rsf	743	21	mFIPV	mFIPV	NNS
cord-269011-230p8rsf	743	22	,	,	,
cord-269011-230p8rsf	743	23	the	the	DT
cord-269011-230p8rsf	743	24	spike	spike	NN
cord-269011-230p8rsf	743	25	ectodomains	ectodomain	NNS
cord-269011-230p8rsf	743	26	of	of	IN
cord-269011-230p8rsf	743	27	which	which	WDT
cord-269011-230p8rsf	743	28	are	be	VBP
cord-269011-230p8rsf	743	29	from	from	IN
cord-269011-230p8rsf	743	30	the	the	DT
cord-269011-230p8rsf	743	31	feline	feline	JJ
cord-269011-230p8rsf	743	32	and	and	CC
cord-269011-230p8rsf	743	33	murine	murine	JJ
cord-269011-230p8rsf	743	34	coronavirus	coronavirus	NN
cord-269011-230p8rsf	743	35	,	,	,
cord-269011-230p8rsf	743	36	respectively	respectively	RB
cord-269011-230p8rsf	743	37	;	;	:
cord-269011-230p8rsf	743	38	these	these	DT
cord-269011-230p8rsf	743	39	studies	study	NNS
cord-269011-230p8rsf	743	40	provided	provide	VBD
cord-269011-230p8rsf	743	41	the	the	DT
cord-269011-230p8rsf	743	42	basis	basis	NN
cord-269011-230p8rsf	743	43	for	for	IN
cord-269011-230p8rsf	743	44	the	the	DT
cord-269011-230p8rsf	743	45	development	development	NN
cord-269011-230p8rsf	743	46	of	of	IN
cord-269011-230p8rsf	743	47	a	a	DT
cord-269011-230p8rsf	743	48	novel	novel	JJ
cord-269011-230p8rsf	743	49	targeted	target	VBN
cord-269011-230p8rsf	743	50	recombination	recombination	NN
cord-269011-230p8rsf	743	51	system	system	NN
cord-269011-230p8rsf	743	52	for	for	IN
cord-269011-230p8rsf	743	53	reverse	reverse	JJ
cord-269011-230p8rsf	743	54	genetics	genetic	NNS
cord-269011-230p8rsf	743	55	of	of	IN
cord-269011-230p8rsf	743	56	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	744	1	(	(	-LRB-
cord-269011-230p8rsf	744	2	Haijema	Haijema	NNP
cord-269011-230p8rsf	744	3	et	et	NNP
cord-269011-230p8rsf	744	4	al	al	NNP
cord-269011-230p8rsf	744	5	.	.	NNP
cord-269011-230p8rsf	744	6	,	,	,
cord-269011-230p8rsf	744	7	2003	2003	CD
cord-269011-230p8rsf	745	1	;	;	:
cord-269011-230p8rsf	745	2	Kuo	Kuo	NNP
cord-269011-230p8rsf	745	3	et	et	NNP
cord-269011-230p8rsf	745	4	al	al	NNP
cord-269011-230p8rsf	745	5	.	.	NNP
cord-269011-230p8rsf	745	6	,	,	,
cord-269011-230p8rsf	745	7	2000	2000	CD
cord-269011-230p8rsf	745	8	)	)	-RRB-
cord-269011-230p8rsf	745	9	.	.	.
cord-269011-230p8rsf	746	1	Further	further	JJ
cord-269011-230p8rsf	746	2	fine	fine	JJ
cord-269011-230p8rsf	746	3	mapping	mapping	NN
cord-269011-230p8rsf	746	4	of	of	IN
cord-269011-230p8rsf	746	5	the	the	DT
cord-269011-230p8rsf	746	6	carboxy	carboxy	JJ
cord-269011-230p8rsf	746	7	-	-	HYPH
cord-269011-230p8rsf	746	8	terminal	terminal	NN
cord-269011-230p8rsf	746	9	parts	part	NNS
cord-269011-230p8rsf	746	10	of	of	IN
cord-269011-230p8rsf	746	11	the	the	DT
cord-269011-230p8rsf	746	12	S	S	NNP
cord-269011-230p8rsf	746	13	protein	protein	NN
cord-269011-230p8rsf	746	14	involved	involve	VBN
cord-269011-230p8rsf	746	15	in	in	IN
cord-269011-230p8rsf	746	16	M	M	NNP
cord-269011-230p8rsf	746	17	-	-	HYPH
cord-269011-230p8rsf	746	18	S	S	NNP
cord-269011-230p8rsf	746	19	protein	protein	NN
cord-269011-230p8rsf	746	20	interaction	interaction	NN
cord-269011-230p8rsf	746	21	revealed	reveal	VBD
cord-269011-230p8rsf	746	22	the	the	DT
cord-269011-230p8rsf	746	23	importance	importance	NN
cord-269011-230p8rsf	746	24	of	of	IN
cord-269011-230p8rsf	746	25	the	the	DT
cord-269011-230p8rsf	746	26	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	746	27	tail	tail	NN
cord-269011-230p8rsf	746	28	.	.	.
cord-269011-230p8rsf	747	1	Again	again	RB
cord-269011-230p8rsf	747	2	using	use	VBG
cord-269011-230p8rsf	747	3	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	747	4	and	and	CC
cord-269011-230p8rsf	747	5	VLP	VLP	NNP
cord-269011-230p8rsf	747	6	incorporation	incorporation	NN
cord-269011-230p8rsf	747	7	assays	assay	NNS
cord-269011-230p8rsf	747	8	,	,	,
cord-269011-230p8rsf	747	9	it	-PRON-	PRP
cord-269011-230p8rsf	747	10	appeared	appear	VBD
cord-269011-230p8rsf	747	11	that	that	IN
cord-269011-230p8rsf	747	12	increasing	increase	VBG
cord-269011-230p8rsf	747	13	truncations	truncation	NNS
cord-269011-230p8rsf	747	14	gradually	gradually	RB
cord-269011-230p8rsf	747	15	abolished	abolish	VBD
cord-269011-230p8rsf	747	16	the	the	DT
cord-269011-230p8rsf	747	17	association	association	NN
cord-269011-230p8rsf	747	18	with	with	IN
cord-269011-230p8rsf	747	19	the	the	DT
cord-269011-230p8rsf	747	20	M	M	NNP
cord-269011-230p8rsf	747	21	protein	protein	NN
cord-269011-230p8rsf	747	22	(	(	-LRB-
cord-269011-230p8rsf	747	23	B.	B.	NNP
cord-269011-230p8rsf	747	24	J.	J.	NNP
cord-269011-230p8rsf	747	25	Bosch	Bosch	NNP
cord-269011-230p8rsf	747	26	,	,	,
cord-269011-230p8rsf	747	27	C.	C.	NNP
cord-269011-230p8rsf	747	28	A.	a.	NN
cord-269011-230p8rsf	747	29	M.	M.	NNP
cord-269011-230p8rsf	747	30	de	de	FW
cord-269011-230p8rsf	747	31	Haan	Haan	NNP
cord-269011-230p8rsf	747	32	,	,	,
cord-269011-230p8rsf	747	33	and	and	CC
cord-269011-230p8rsf	747	34	P.	P.	NNP
cord-269011-230p8rsf	747	35	J.	J.	NNP
cord-269011-230p8rsf	747	36	M.	M.	NNP
cord-269011-230p8rsf	747	37	Rottier	Rottier	NNP
cord-269011-230p8rsf	747	38	,	,	,
cord-269011-230p8rsf	747	39	unpublished	unpublished	JJ
cord-269011-230p8rsf	747	40	results	result	NNS
cord-269011-230p8rsf	747	41	)	)	-RRB-
cord-269011-230p8rsf	747	42	.	.	.
cord-269011-230p8rsf	748	1	The	the	DT
cord-269011-230p8rsf	748	2	significance	significance	NN
cord-269011-230p8rsf	748	3	of	of	IN
cord-269011-230p8rsf	748	4	the	the	DT
cord-269011-230p8rsf	748	5	tail	tail	NN
cord-269011-230p8rsf	748	6	domain	domain	NN
cord-269011-230p8rsf	748	7	was	be	VBD
cord-269011-230p8rsf	748	8	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	748	9	most	most	RBS
cord-269011-230p8rsf	748	10	convincingly	convincingly	RB
cord-269011-230p8rsf	748	11	by	by	IN
cord-269011-230p8rsf	748	12	showing	show	VBG
cord-269011-230p8rsf	748	13	the	the	DT
cord-269011-230p8rsf	748	14	coimmunoprecipitation	coimmunoprecipitation	NN
cord-269011-230p8rsf	748	15	and	and	CC
cord-269011-230p8rsf	748	16	VLP	VLP	NNP
cord-269011-230p8rsf	748	17	assembly	assembly	NN
cord-269011-230p8rsf	748	18	of	of	IN
cord-269011-230p8rsf	748	19	a	a	DT
cord-269011-230p8rsf	748	20	chimeric	chimeric	JJ
cord-269011-230p8rsf	748	21	VSV	VSV	NNP
cord-269011-230p8rsf	748	22	G	G	NNP
cord-269011-230p8rsf	748	23	protein	protein	NN
cord-269011-230p8rsf	748	24	the	the	DT
cord-269011-230p8rsf	748	25	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	748	26	tail	tail	NN
cord-269011-230p8rsf	748	27	of	of	IN
cord-269011-230p8rsf	748	28	which	which	WDT
cord-269011-230p8rsf	748	29	had	have	VBD
cord-269011-230p8rsf	748	30	been	be	VBN
cord-269011-230p8rsf	748	31	replaced	replace	VBN
cord-269011-230p8rsf	748	32	by	by	IN
cord-269011-230p8rsf	748	33	that	that	DT
cord-269011-230p8rsf	748	34	of	of	IN
cord-269011-230p8rsf	748	35	MHV	MHV	NNP
cord-269011-230p8rsf	748	36	S.	S.	NNP
cord-269011-230p8rsf	748	37	Tail	Tail	NNP
cord-269011-230p8rsf	748	38	truncations	truncation	NNS
cord-269011-230p8rsf	748	39	were	be	VBD
cord-269011-230p8rsf	748	40	tolerated	tolerate	VBN
cord-269011-230p8rsf	748	41	in	in	IN
cord-269011-230p8rsf	748	42	the	the	DT
cord-269011-230p8rsf	748	43	context	context	NN
cord-269011-230p8rsf	748	44	of	of	IN
cord-269011-230p8rsf	748	45	the	the	DT
cord-269011-230p8rsf	748	46	coronavirus	coronavirus	NN
cord-269011-230p8rsf	748	47	;	;	,
cord-269011-230p8rsf	748	48	recombinant	recombinant	JJ
cord-269011-230p8rsf	748	49	MHVs	MHVs	NNP
cord-269011-230p8rsf	748	50	were	be	VBD
cord-269011-230p8rsf	748	51	generated	generate	VBN
cord-269011-230p8rsf	748	52	that	that	IN
cord-269011-230p8rsf	748	53	lacked	lack	VBD
cord-269011-230p8rsf	748	54	12	12	CD
cord-269011-230p8rsf	748	55	or	or	CC
cord-269011-230p8rsf	748	56	25	25	CD
cord-269011-230p8rsf	748	57	(	(	-LRB-
cord-269011-230p8rsf	748	58	but	but	CC
cord-269011-230p8rsf	748	59	not	not	RB
cord-269011-230p8rsf	748	60	35	35	CD
cord-269011-230p8rsf	748	61	)	)	-RRB-
cord-269011-230p8rsf	748	62	residues	residue	NNS
cord-269011-230p8rsf	748	63	from	from	IN
cord-269011-230p8rsf	748	64	the	the	DT
cord-269011-230p8rsf	748	65	S	S	NNP
cord-269011-230p8rsf	748	66	protein	protein	NN
cord-269011-230p8rsf	748	67	carboxy	carboxy	NN
cord-269011-230p8rsf	748	68	terminus	terminus	NN
cord-269011-230p8rsf	748	69	,	,	,
cord-269011-230p8rsf	748	70	but	but	CC
cord-269011-230p8rsf	748	71	their	-PRON-	PRP$
cord-269011-230p8rsf	748	72	growth	growth	NN
cord-269011-230p8rsf	748	73	was	be	VBD
cord-269011-230p8rsf	748	74	impaired	impair	VBN
cord-269011-230p8rsf	748	75	by	by	IN
cord-269011-230p8rsf	748	76	about	about	RB
cord-269011-230p8rsf	748	77	10-and	10-and	CD
cord-269011-230p8rsf	748	78	10	10	CD
cord-269011-230p8rsf	748	79	4	4	CD
cord-269011-230p8rsf	748	80	-fold	-fold	NN
cord-269011-230p8rsf	748	81	,	,	,
cord-269011-230p8rsf	748	82	respectively	respectively	RB
cord-269011-230p8rsf	748	83	.	.	.
cord-269011-230p8rsf	749	1	Also	also	RB
cord-269011-230p8rsf	749	2	,	,	,
cord-269011-230p8rsf	749	3	tail	tail	NN
cord-269011-230p8rsf	749	4	extensions	extension	NNS
cord-269011-230p8rsf	749	5	were	be	VBD
cord-269011-230p8rsf	749	6	tolerated	tolerate	VBN
cord-269011-230p8rsf	749	7	,	,	,
cord-269011-230p8rsf	749	8	allowing	allow	VBG
cord-269011-230p8rsf	749	9	the	the	DT
cord-269011-230p8rsf	749	10	construction	construction	NN
cord-269011-230p8rsf	749	11	of	of	IN
cord-269011-230p8rsf	749	12	a	a	DT
cord-269011-230p8rsf	749	13	recombinant	recombinant	JJ
cord-269011-230p8rsf	749	14	MHV	mhv	NN
cord-269011-230p8rsf	749	15	with	with	IN
cord-269011-230p8rsf	749	16	a	a	DT
cord-269011-230p8rsf	749	17	spike	spike	NN
cord-269011-230p8rsf	749	18	protein	protein	NN
cord-269011-230p8rsf	749	19	extended	extend	VBN
cord-269011-230p8rsf	749	20	at	at	IN
cord-269011-230p8rsf	749	21	its	-PRON-	PRP$
cord-269011-230p8rsf	749	22	carboxy	carboxy	JJ
cord-269011-230p8rsf	749	23	terminus	terminus	NN
cord-269011-230p8rsf	749	24	by	by	IN
cord-269011-230p8rsf	749	25	the	the	DT
cord-269011-230p8rsf	749	26	green	green	JJ
cord-269011-230p8rsf	749	27	fluorescent	fluorescent	NN
cord-269011-230p8rsf	749	28	protein	protein	NN
cord-269011-230p8rsf	749	29	(	(	-LRB-
cord-269011-230p8rsf	749	30	GFP	GFP	NNP
cord-269011-230p8rsf	749	31	)	)	-RRB-
cord-269011-230p8rsf	749	32	,	,	,
cord-269011-230p8rsf	749	33	yielding	yield	VBG
cord-269011-230p8rsf	749	34	green	green	JJ
cord-269011-230p8rsf	749	35	fluorescent	fluorescent	NN
cord-269011-230p8rsf	749	36	virions	virion	NNS
cord-269011-230p8rsf	749	37	(	(	-LRB-
cord-269011-230p8rsf	749	38	Bosch	Bosch	NNP
cord-269011-230p8rsf	749	39	et	et	NNP
cord-269011-230p8rsf	749	40	al	al	NNP
cord-269011-230p8rsf	749	41	.	.	NNP
cord-269011-230p8rsf	749	42	,	,	,
cord-269011-230p8rsf	749	43	2004a	2004a	CD
cord-269011-230p8rsf	749	44	)	)	-RRB-
cord-269011-230p8rsf	749	45	.	.	.
cord-269011-230p8rsf	750	1	The	the	DT
cord-269011-230p8rsf	750	2	extension	extension	NN
cord-269011-230p8rsf	750	3	was	be	VBD
cord-269011-230p8rsf	750	4	,	,	,
cord-269011-230p8rsf	750	5	however	however	RB
cord-269011-230p8rsf	750	6	,	,	,
cord-269011-230p8rsf	750	7	lost	lose	VBD
cord-269011-230p8rsf	750	8	quite	quite	RB
cord-269011-230p8rsf	750	9	rapidly	rapidly	RB
cord-269011-230p8rsf	750	10	on	on	IN
cord-269011-230p8rsf	750	11	serial	serial	JJ
cord-269011-230p8rsf	750	12	passaging	passaging	NN
cord-269011-230p8rsf	750	13	of	of	IN
cord-269011-230p8rsf	750	14	the	the	DT
cord-269011-230p8rsf	750	15	virus	virus	NN
cord-269011-230p8rsf	750	16	.	.	.
cord-269011-230p8rsf	751	1	Molecular	molecular	JJ
cord-269011-230p8rsf	751	2	details	detail	NNS
cord-269011-230p8rsf	751	3	of	of	IN
cord-269011-230p8rsf	751	4	the	the	DT
cord-269011-230p8rsf	751	5	interaction	interaction	NN
cord-269011-230p8rsf	751	6	of	of	IN
cord-269011-230p8rsf	751	7	M	M	NNP
cord-269011-230p8rsf	751	8	and	and	CC
cord-269011-230p8rsf	751	9	HE	HE	NNP
cord-269011-230p8rsf	751	10	proteins	protein	VBZ
cord-269011-230p8rsf	751	11	and	and	CC
cord-269011-230p8rsf	751	12	the	the	DT
cord-269011-230p8rsf	751	13	requirements	requirement	NNS
cord-269011-230p8rsf	751	14	of	of	IN
cord-269011-230p8rsf	751	15	HE	he	PRP
cord-269011-230p8rsf	751	16	for	for	IN
cord-269011-230p8rsf	751	17	incorporation	incorporation	NN
cord-269011-230p8rsf	751	18	into	into	IN
cord-269011-230p8rsf	751	19	viral	viral	JJ
cord-269011-230p8rsf	751	20	particles	particle	NNS
cord-269011-230p8rsf	751	21	have	have	VBP
cord-269011-230p8rsf	751	22	not	not	RB
cord-269011-230p8rsf	751	23	been	be	VBN
cord-269011-230p8rsf	751	24	described	describe	VBN
cord-269011-230p8rsf	751	25	.	.	.
cord-269011-230p8rsf	752	1	One	one	CD
cord-269011-230p8rsf	752	2	study	study	NN
cord-269011-230p8rsf	752	3	reported	report	VBD
cord-269011-230p8rsf	752	4	that	that	IN
cord-269011-230p8rsf	752	5	HE	HE	NNP
cord-269011-230p8rsf	752	6	protein	protein	NN
cord-269011-230p8rsf	752	7	mutants	mutant	NNS
cord-269011-230p8rsf	752	8	lacking	lack	VBG
cord-269011-230p8rsf	752	9	part	part	NN
cord-269011-230p8rsf	752	10	of	of	IN
cord-269011-230p8rsf	752	11	their	-PRON-	PRP$
cord-269011-230p8rsf	752	12	ectodomain	ectodomain	NN
cord-269011-230p8rsf	752	13	were	be	VBD
cord-269011-230p8rsf	752	14	not	not	RB
cord-269011-230p8rsf	752	15	assembled	assemble	VBN
cord-269011-230p8rsf	752	16	into	into	IN
cord-269011-230p8rsf	752	17	particles	particle	NNS
cord-269011-230p8rsf	752	18	(	(	-LRB-
cord-269011-230p8rsf	752	19	Liao	Liao	NNP
cord-269011-230p8rsf	752	20	et	et	NNP
cord-269011-230p8rsf	752	21	al	al	NNP
cord-269011-230p8rsf	752	22	.	.	NNP
cord-269011-230p8rsf	752	23	,	,	,
cord-269011-230p8rsf	752	24	1995	1995	CD
cord-269011-230p8rsf	752	25	)	)	-RRB-
cord-269011-230p8rsf	752	26	.	.	.
cord-269011-230p8rsf	753	1	Most	most	RBS
cord-269011-230p8rsf	753	2	likely	likely	JJ
cord-269011-230p8rsf	753	3	,	,	,
cord-269011-230p8rsf	753	4	however	however	RB
cord-269011-230p8rsf	753	5	,	,	,
cord-269011-230p8rsf	753	6	this	this	DT
cord-269011-230p8rsf	753	7	observation	observation	NN
cord-269011-230p8rsf	753	8	was	be	VBD
cord-269011-230p8rsf	753	9	due	due	JJ
cord-269011-230p8rsf	753	10	to	to	IN
cord-269011-230p8rsf	753	11	folding	folding	NN
cord-269011-230p8rsf	753	12	or	or	CC
cord-269011-230p8rsf	753	13	maturation	maturation	NN
cord-269011-230p8rsf	753	14	defects	defect	NNS
cord-269011-230p8rsf	753	15	of	of	IN
cord-269011-230p8rsf	753	16	the	the	DT
cord-269011-230p8rsf	753	17	mutant	mutant	JJ
cord-269011-230p8rsf	753	18	proteins	protein	NNS
cord-269011-230p8rsf	753	19	.	.	.
cord-269011-230p8rsf	754	1	In	in	IN
cord-269011-230p8rsf	754	2	another	another	DT
cord-269011-230p8rsf	754	3	study	study	NN
cord-269011-230p8rsf	754	4	the	the	DT
cord-269011-230p8rsf	754	5	BCoV	BCoV	NNP
cord-269011-230p8rsf	754	6	S	S	NNP
cord-269011-230p8rsf	754	7	and	and	CC
cord-269011-230p8rsf	754	8	HE	HE	NNP
cord-269011-230p8rsf	754	9	proteins	protein	NNS
cord-269011-230p8rsf	754	10	were	be	VBD
cord-269011-230p8rsf	754	11	shown	show	VBN
cord-269011-230p8rsf	754	12	to	to	TO
cord-269011-230p8rsf	754	13	be	be	VB
cord-269011-230p8rsf	754	14	incorporated	incorporate	VBN
cord-269011-230p8rsf	754	15	into	into	IN
cord-269011-230p8rsf	754	16	MHV	MHV	NNP
cord-269011-230p8rsf	754	17	particles	particle	NNS
cord-269011-230p8rsf	754	18	when	when	WRB
cord-269011-230p8rsf	754	19	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	754	20	in	in	IN
cord-269011-230p8rsf	754	21	MHV	MHV	NNP
cord-269011-230p8rsf	754	22	-	-	HYPH
cord-269011-230p8rsf	754	23	infected	infect	VBN
cord-269011-230p8rsf	754	24	cells	cell	NNS
cord-269011-230p8rsf	754	25	.	.	.
cord-269011-230p8rsf	755	1	Apparently	apparently	RB
cord-269011-230p8rsf	755	2	,	,	,
cord-269011-230p8rsf	755	3	homology	homology	NN
cord-269011-230p8rsf	755	4	between	between	IN
cord-269011-230p8rsf	755	5	the	the	DT
cord-269011-230p8rsf	755	6	proteins	protein	NNS
cord-269011-230p8rsf	755	7	of	of	IN
cord-269011-230p8rsf	755	8	these	these	DT
cord-269011-230p8rsf	755	9	related	relate	VBN
cord-269011-230p8rsf	755	10	group	group	NN
cord-269011-230p8rsf	755	11	2	2	CD
cord-269011-230p8rsf	755	12	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	755	13	is	be	VBZ
cord-269011-230p8rsf	755	14	sufficiently	sufficiently	RB
cord-269011-230p8rsf	755	15	high	high	JJ
cord-269011-230p8rsf	755	16	for	for	IN
cord-269011-230p8rsf	755	17	heterologous	heterologous	NNP
cord-269011-230p8rsf	755	18	M	M	NNP
cord-269011-230p8rsf	755	19	-	-	HYPH
cord-269011-230p8rsf	755	20	S	S	NNP
cord-269011-230p8rsf	755	21	and	and	CC
cord-269011-230p8rsf	755	22	M	M	NNP
cord-269011-230p8rsf	755	23	-	-	HYPH
cord-269011-230p8rsf	755	24	HE	HE	NNP
cord-269011-230p8rsf	755	25	interactions	interaction	VBZ
cord-269011-230p8rsf	755	26	to	to	TO
cord-269011-230p8rsf	755	27	occur	occur	VB
cord-269011-230p8rsf	755	28	(	(	-LRB-
cord-269011-230p8rsf	755	29	Popova	Popova	NNP
cord-269011-230p8rsf	755	30	and	and	CC
cord-269011-230p8rsf	755	31	Zhang	Zhang	NNP
cord-269011-230p8rsf	755	32	,	,	,
cord-269011-230p8rsf	755	33	2002	2002	CD
cord-269011-230p8rsf	755	34	)	)	-RRB-
cord-269011-230p8rsf	755	35	.	.	.
cord-269011-230p8rsf	756	1	Numerous	numerous	JJ
cord-269011-230p8rsf	756	2	electron	electron	NN
cord-269011-230p8rsf	756	3	microscopy	microscopy	NN
cord-269011-230p8rsf	756	4	studies	study	NNS
cord-269011-230p8rsf	756	5	have	have	VBP
cord-269011-230p8rsf	756	6	pictured	picture	VBN
cord-269011-230p8rsf	756	7	the	the	DT
cord-269011-230p8rsf	756	8	process	process	NN
cord-269011-230p8rsf	756	9	of	of	IN
cord-269011-230p8rsf	756	10	virion	virion	NN
cord-269011-230p8rsf	756	11	assembly	assembly	NN
cord-269011-230p8rsf	756	12	in	in	IN
cord-269011-230p8rsf	756	13	the	the	DT
cord-269011-230p8rsf	756	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	756	15	-	-	HYPH
cord-269011-230p8rsf	756	16	infected	infect	VBN
cord-269011-230p8rsf	756	17	cell	cell	NN
cord-269011-230p8rsf	756	18	.	.	.
cord-269011-230p8rsf	757	1	They	-PRON-	PRP
cord-269011-230p8rsf	757	2	show	show	VBP
cord-269011-230p8rsf	757	3	the	the	DT
cord-269011-230p8rsf	757	4	close	close	JJ
cord-269011-230p8rsf	757	5	apposition	apposition	NN
cord-269011-230p8rsf	757	6	of	of	IN
cord-269011-230p8rsf	757	7	-	-	:
cord-269011-230p8rsf	757	8	presumably	presumably	RB
cord-269011-230p8rsf	757	9	preassembled	preassemble	VBN
cord-269011-230p8rsf	757	10	-	-	HYPH
cord-269011-230p8rsf	757	11	tubular	tubular	JJ
cord-269011-230p8rsf	757	12	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	757	13	to	to	IN
cord-269011-230p8rsf	757	14	intracellular	intracellular	JJ
cord-269011-230p8rsf	757	15	membranes	membrane	NNS
cord-269011-230p8rsf	757	16	,	,	,
cord-269011-230p8rsf	757	17	the	the	DT
cord-269011-230p8rsf	757	18	appearance	appearance	NN
cord-269011-230p8rsf	757	19	of	of	IN
cord-269011-230p8rsf	757	20	membrane	membrane	NN
cord-269011-230p8rsf	757	21	curvature	curvature	NN
cord-269011-230p8rsf	757	22	at	at	IN
cord-269011-230p8rsf	757	23	the	the	DT
cord-269011-230p8rsf	757	24	contact	contact	NN
cord-269011-230p8rsf	757	25	sites	site	NNS
cord-269011-230p8rsf	757	26	,	,	,
cord-269011-230p8rsf	757	27	the	the	DT
cord-269011-230p8rsf	757	28	"	"	``
cord-269011-230p8rsf	757	29	growth	growth	NN
cord-269011-230p8rsf	757	30	"	"	''
cord-269011-230p8rsf	757	31	of	of	IN
cord-269011-230p8rsf	757	32	these	these	DT
cord-269011-230p8rsf	757	33	buds	bud	NNS
cord-269011-230p8rsf	757	34	into	into	IN
cord-269011-230p8rsf	757	35	particle	particle	NN
cord-269011-230p8rsf	757	36	-	-	HYPH
cord-269011-230p8rsf	757	37	sized	sized	JJ
cord-269011-230p8rsf	757	38	vesicles	vesicle	NNS
cord-269011-230p8rsf	757	39	,	,	,
cord-269011-230p8rsf	757	40	and	and	CC
cord-269011-230p8rsf	757	41	the	the	DT
cord-269011-230p8rsf	757	42	ultimate	ultimate	JJ
cord-269011-230p8rsf	757	43	detachment	detachment	NN
cord-269011-230p8rsf	757	44	of	of	IN
cord-269011-230p8rsf	757	45	virions	virion	NNS
cord-269011-230p8rsf	757	46	from	from	IN
cord-269011-230p8rsf	757	47	the	the	DT
cord-269011-230p8rsf	757	48	membranes	membrane	NNS
cord-269011-230p8rsf	757	49	by	by	IN
cord-269011-230p8rsf	757	50	pinching	pinch	VBG
cord-269011-230p8rsf	757	51	off	off	RP
cord-269011-230p8rsf	757	52	.	.	.
cord-269011-230p8rsf	758	1	It	-PRON-	PRP
cord-269011-230p8rsf	758	2	has	have	VBZ
cord-269011-230p8rsf	758	3	become	become	VBN
cord-269011-230p8rsf	758	4	clear	clear	JJ
cord-269011-230p8rsf	758	5	that	that	IN
cord-269011-230p8rsf	758	6	the	the	DT
cord-269011-230p8rsf	758	7	M	M	NNP
cord-269011-230p8rsf	758	8	protein	protein	NN
cord-269011-230p8rsf	758	9	is	be	VBZ
cord-269011-230p8rsf	758	10	the	the	DT
cord-269011-230p8rsf	758	11	central	central	JJ
cord-269011-230p8rsf	758	12	player	player	NN
cord-269011-230p8rsf	758	13	,	,	,
cord-269011-230p8rsf	758	14	which	which	WDT
cord-269011-230p8rsf	758	15	,	,	,
cord-269011-230p8rsf	758	16	through	through	IN
cord-269011-230p8rsf	758	17	its	-PRON-	PRP$
cord-269011-230p8rsf	758	18	interactions	interaction	NNS
cord-269011-230p8rsf	758	19	with	with	IN
cord-269011-230p8rsf	758	20	every	every	DT
cord-269011-230p8rsf	758	21	known	know	VBN
cord-269011-230p8rsf	758	22	component	component	NN
cord-269011-230p8rsf	758	23	of	of	IN
cord-269011-230p8rsf	758	24	the	the	DT
cord-269011-230p8rsf	758	25	virion	virion	NN
cord-269011-230p8rsf	758	26	,	,	,
cord-269011-230p8rsf	758	27	orchestrates	orchestrate	VBZ
cord-269011-230p8rsf	758	28	the	the	DT
cord-269011-230p8rsf	758	29	entire	entire	JJ
cord-269011-230p8rsf	758	30	assembly	assembly	NN
cord-269011-230p8rsf	758	31	process	process	NN
cord-269011-230p8rsf	758	32	(	(	-LRB-
cord-269011-230p8rsf	758	33	see	see	VB
cord-269011-230p8rsf	758	34	Fig	Fig	NNP
cord-269011-230p8rsf	758	35	.	.	NNP
cord-269011-230p8rsf	758	36	7	7	CD
cord-269011-230p8rsf	758	37	)	)	-RRB-
cord-269011-230p8rsf	758	38	.	.	.
cord-269011-230p8rsf	759	1	In	in	IN
cord-269011-230p8rsf	759	2	the	the	DT
cord-269011-230p8rsf	759	3	process	process	NN
cord-269011-230p8rsf	759	4	two	two	CD
cord-269011-230p8rsf	759	5	levels	level	NNS
cord-269011-230p8rsf	759	6	of	of	IN
cord-269011-230p8rsf	759	7	interaction	interaction	NN
cord-269011-230p8rsf	759	8	can	can	MD
cord-269011-230p8rsf	759	9	be	be	VB
cord-269011-230p8rsf	759	10	distinguished	distinguish	VBN
cord-269011-230p8rsf	759	11	.	.	.
cord-269011-230p8rsf	760	1	One	one	CD
cord-269011-230p8rsf	760	2	is	be	VBZ
cord-269011-230p8rsf	760	3	the	the	DT
cord-269011-230p8rsf	760	4	level	level	NN
cord-269011-230p8rsf	760	5	of	of	IN
cord-269011-230p8rsf	760	6	the	the	DT
cord-269011-230p8rsf	760	7	membrane	membrane	NN
cord-269011-230p8rsf	760	8	where	where	WRB
cord-269011-230p8rsf	760	9	,	,	,
cord-269011-230p8rsf	760	10	as	as	IN
cord-269011-230p8rsf	760	11	detailed	detail	VBN
cord-269011-230p8rsf	760	12	in	in	IN
cord-269011-230p8rsf	760	13	the	the	DT
cord-269011-230p8rsf	760	14	previous	previous	JJ
cord-269011-230p8rsf	760	15	section	section	NN
cord-269011-230p8rsf	760	16	,	,	,
cord-269011-230p8rsf	760	17	the	the	DT
cord-269011-230p8rsf	760	18	M	M	NNP
cord-269011-230p8rsf	760	19	protein	protein	NN
cord-269011-230p8rsf	760	20	interacts	interact	VBZ
cord-269011-230p8rsf	760	21	(	(	-LRB-
cord-269011-230p8rsf	760	22	1	1	LS
cord-269011-230p8rsf	760	23	)	)	-RRB-
cord-269011-230p8rsf	760	24	with	with	IN
cord-269011-230p8rsf	760	25	itself	-PRON-	PRP
cord-269011-230p8rsf	760	26	,	,	,
cord-269011-230p8rsf	760	27	to	to	TO
cord-269011-230p8rsf	760	28	generate	generate	VB
cord-269011-230p8rsf	760	29	the	the	DT
cord-269011-230p8rsf	760	30	basic	basic	JJ
cord-269011-230p8rsf	760	31	molecular	molecular	JJ
cord-269011-230p8rsf	760	32	framework	framework	NN
cord-269011-230p8rsf	760	33	of	of	IN
cord-269011-230p8rsf	760	34	the	the	DT
cord-269011-230p8rsf	760	35	viral	viral	JJ
cord-269011-230p8rsf	760	36	envelope	envelope	NN
cord-269011-230p8rsf	760	37	,	,	,
cord-269011-230p8rsf	760	38	(	(	-LRB-
cord-269011-230p8rsf	760	39	2	2	LS
cord-269011-230p8rsf	760	40	)	)	-RRB-
cord-269011-230p8rsf	760	41	with	with	IN
cord-269011-230p8rsf	760	42	the	the	DT
cord-269011-230p8rsf	760	43	E	e	NN
cord-269011-230p8rsf	760	44	protein	protein	NN
cord-269011-230p8rsf	760	45	,	,	,
cord-269011-230p8rsf	760	46	to	to	TO
cord-269011-230p8rsf	760	47	induce	induce	VB
cord-269011-230p8rsf	760	48	curving	curve	VBG
cord-269011-230p8rsf	760	49	and	and	CC
cord-269011-230p8rsf	760	50	budding	budding	NN
cord-269011-230p8rsf	760	51	of	of	IN
cord-269011-230p8rsf	760	52	the	the	DT
cord-269011-230p8rsf	760	53	M	M	NNP
cord-269011-230p8rsf	760	54	protein	protein	NN
cord-269011-230p8rsf	760	55	-	-	HYPH
cord-269011-230p8rsf	760	56	modified	modify	VBN
cord-269011-230p8rsf	760	57	membrane	membrane	NN
cord-269011-230p8rsf	760	58	,	,	,
cord-269011-230p8rsf	760	59	and	and	CC
cord-269011-230p8rsf	760	60	(	(	-LRB-
cord-269011-230p8rsf	760	61	3	3	LS
cord-269011-230p8rsf	760	62	)	)	-RRB-
cord-269011-230p8rsf	760	63	with	with	IN
cord-269011-230p8rsf	760	64	S	S	NNP
cord-269011-230p8rsf	760	65	and	and	CC
cord-269011-230p8rsf	760	66	HE	HE	NNP
cord-269011-230p8rsf	760	67	,	,	,
cord-269011-230p8rsf	760	68	to	to	TO
cord-269011-230p8rsf	760	69	coassemble	coassemble	VB
cord-269011-230p8rsf	760	70	these	these	DT
cord-269011-230p8rsf	760	71	spikes	spike	NNS
cord-269011-230p8rsf	760	72	into	into	IN
cord-269011-230p8rsf	760	73	the	the	DT
cord-269011-230p8rsf	760	74	viral	viral	JJ
cord-269011-230p8rsf	760	75	envelope	envelope	NN
cord-269011-230p8rsf	760	76	.	.	.
cord-269011-230p8rsf	761	1	The	the	DT
cord-269011-230p8rsf	761	2	other	other	JJ
cord-269011-230p8rsf	761	3	level	level	NN
cord-269011-230p8rsf	761	4	at	at	IN
cord-269011-230p8rsf	761	5	which	which	WDT
cord-269011-230p8rsf	761	6	the	the	DT
cord-269011-230p8rsf	761	7	M	M	NNP
cord-269011-230p8rsf	761	8	protein	protein	NN
cord-269011-230p8rsf	761	9	operates	operate	VBZ
cord-269011-230p8rsf	761	10	involves	involve	VBZ
cord-269011-230p8rsf	761	11	the	the	DT
cord-269011-230p8rsf	761	12	incorporation	incorporation	NN
cord-269011-230p8rsf	761	13	of	of	IN
cord-269011-230p8rsf	761	14	the	the	DT
cord-269011-230p8rsf	761	15	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	761	16	into	into	IN
cord-269011-230p8rsf	761	17	the	the	DT
cord-269011-230p8rsf	761	18	virion	virion	NN
cord-269011-230p8rsf	761	19	.	.	.
cord-269011-230p8rsf	762	1	Here	here	RB
cord-269011-230p8rsf	762	2	,	,	,
cord-269011-230p8rsf	762	3	two	two	CD
cord-269011-230p8rsf	762	4	types	type	NNS
cord-269011-230p8rsf	762	5	of	of	IN
cord-269011-230p8rsf	762	6	interactions	interaction	NNS
cord-269011-230p8rsf	762	7	have	have	VBP
cord-269011-230p8rsf	762	8	been	be	VBN
cord-269011-230p8rsf	762	9	described	describe	VBN
cord-269011-230p8rsf	762	10	:	:	:
cord-269011-230p8rsf	762	11	interactions	interaction	NNS
cord-269011-230p8rsf	762	12	of	of	IN
cord-269011-230p8rsf	762	13	the	the	DT
cord-269011-230p8rsf	762	14	M	M	NNP
cord-269011-230p8rsf	762	15	protein	protein	NN
cord-269011-230p8rsf	762	16	with	with	IN
cord-269011-230p8rsf	762	17	the	the	DT
cord-269011-230p8rsf	762	18	N	N	NNP
cord-269011-230p8rsf	762	19	protein	protein	NN
cord-269011-230p8rsf	762	20	and	and	CC
cord-269011-230p8rsf	762	21	with	with	IN
cord-269011-230p8rsf	762	22	the	the	DT
cord-269011-230p8rsf	762	23	viral	viral	JJ
cord-269011-230p8rsf	762	24	genome	genome	NN
cord-269011-230p8rsf	762	25	.	.	.
cord-269011-230p8rsf	763	1	An	an	DT
cord-269011-230p8rsf	763	2	instrumental	instrumental	JJ
cord-269011-230p8rsf	763	3	role	role	NN
cord-269011-230p8rsf	763	4	of	of	IN
cord-269011-230p8rsf	763	5	the	the	DT
cord-269011-230p8rsf	763	6	M	M	NNP
cord-269011-230p8rsf	763	7	protein	protein	NN
cord-269011-230p8rsf	763	8	in	in	IN
cord-269011-230p8rsf	763	9	drawing	draw	VBG
cord-269011-230p8rsf	763	10	the	the	DT
cord-269011-230p8rsf	763	11	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	763	12	into	into	IN
cord-269011-230p8rsf	763	13	the	the	DT
cord-269011-230p8rsf	763	14	budding	bud	VBG
cord-269011-230p8rsf	763	15	particle	particle	NN
cord-269011-230p8rsf	763	16	is	be	VBZ
cord-269011-230p8rsf	763	17	indicated	indicate	VBN
cord-269011-230p8rsf	763	18	by	by	IN
cord-269011-230p8rsf	763	19	their	-PRON-	PRP$
cord-269011-230p8rsf	763	20	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	763	21	interaction	interaction	NN
cord-269011-230p8rsf	763	22	in	in	IN
cord-269011-230p8rsf	763	23	studies	study	NNS
cord-269011-230p8rsf	763	24	with	with	IN
cord-269011-230p8rsf	763	25	virion	virion	NN
cord-269011-230p8rsf	763	26	preparations	preparation	NNS
cord-269011-230p8rsf	763	27	.	.	.
cord-269011-230p8rsf	764	1	The	the	DT
cord-269011-230p8rsf	764	2	M	M	NNP
cord-269011-230p8rsf	764	3	protein	protein	NN
cord-269011-230p8rsf	764	4	has	have	VBZ
cord-269011-230p8rsf	764	5	been	be	VBN
cord-269011-230p8rsf	764	6	shown	show	VBN
cord-269011-230p8rsf	764	7	to	to	TO
cord-269011-230p8rsf	764	8	remain	remain	VB
cord-269011-230p8rsf	764	9	associated	associate	VBN
cord-269011-230p8rsf	764	10	with	with	IN
cord-269011-230p8rsf	764	11	subviral	subviral	JJ
cord-269011-230p8rsf	764	12	particles	particle	NNS
cord-269011-230p8rsf	764	13	obtained	obtain	VBN
cord-269011-230p8rsf	764	14	after	after	IN
cord-269011-230p8rsf	764	15	treatment	treatment	NN
cord-269011-230p8rsf	764	16	of	of	IN
cord-269011-230p8rsf	764	17	virions	virion	NNS
cord-269011-230p8rsf	764	18	with	with	IN
cord-269011-230p8rsf	764	19	detergent	detergent	NN
cord-269011-230p8rsf	764	20	that	that	WDT
cord-269011-230p8rsf	764	21	removes	remove	VBZ
cord-269011-230p8rsf	764	22	the	the	DT
cord-269011-230p8rsf	764	23	spikes	spike	NNS
cord-269011-230p8rsf	764	24	(	(	-LRB-
cord-269011-230p8rsf	764	25	Escors	Escors	NNP
cord-269011-230p8rsf	764	26	et	et	NNP
cord-269011-230p8rsf	764	27	al	al	NNP
cord-269011-230p8rsf	764	28	.	.	NNP
cord-269011-230p8rsf	764	29	,	,	,
cord-269011-230p8rsf	764	30	2001a	2001a	CD
cord-269011-230p8rsf	764	31	,	,	,
cord-269011-230p8rsf	764	32	b	b	LS
cord-269011-230p8rsf	764	33	;	;	:
cord-269011-230p8rsf	764	34	Garwes	Garwes	NNP
cord-269011-230p8rsf	764	35	et	et	FW
cord-269011-230p8rsf	764	36	al	al	NNP
cord-269011-230p8rsf	764	37	.	.	NNP
cord-269011-230p8rsf	764	38	,	,	,
cord-269011-230p8rsf	764	39	1976	1976	CD
cord-269011-230p8rsf	764	40	;	;	:
cord-269011-230p8rsf	764	41	Lancer	Lancer	NNP
cord-269011-230p8rsf	764	42	and	and	CC
cord-269011-230p8rsf	764	43	Howard	Howard	NNP
cord-269011-230p8rsf	764	44	,	,	,
cord-269011-230p8rsf	764	45	1980	1980	CD
cord-269011-230p8rsf	764	46	;	;	:
cord-269011-230p8rsf	764	47	Wege	Wege	NNP
cord-269011-230p8rsf	764	48	et	et	NNP
cord-269011-230p8rsf	764	49	al	al	NNP
cord-269011-230p8rsf	764	50	.	.	NNP
cord-269011-230p8rsf	764	51	,	,	,
cord-269011-230p8rsf	764	52	1979	1979	CD
cord-269011-230p8rsf	764	53	)	)	-RRB-
cord-269011-230p8rsf	764	54	.	.	.
cord-269011-230p8rsf	765	1	The	the	DT
cord-269011-230p8rsf	765	2	association	association	NN
cord-269011-230p8rsf	765	3	was	be	VBD
cord-269011-230p8rsf	765	4	shown	show	VBN
cord-269011-230p8rsf	765	5	for	for	IN
cord-269011-230p8rsf	765	6	MHV	MHV	NNP
cord-269011-230p8rsf	765	7	to	to	TO
cord-269011-230p8rsf	765	8	be	be	VB
cord-269011-230p8rsf	765	9	temperature	temperature	NN
cord-269011-230p8rsf	765	10	dependent	dependent	JJ
cord-269011-230p8rsf	765	11	(	(	-LRB-
cord-269011-230p8rsf	765	12	Sturman	Sturman	NNP
cord-269011-230p8rsf	765	13	et	et	NNP
cord-269011-230p8rsf	765	14	al	al	NNP
cord-269011-230p8rsf	765	15	.	.	NNP
cord-269011-230p8rsf	765	16	,	,	,
cord-269011-230p8rsf	765	17	1980	1980	CD
cord-269011-230p8rsf	765	18	)	)	-RRB-
cord-269011-230p8rsf	765	19	.	.	.
cord-269011-230p8rsf	766	1	In	in	IN
cord-269011-230p8rsf	766	2	the	the	DT
cord-269011-230p8rsf	766	3	case	case	NN
cord-269011-230p8rsf	766	4	of	of	IN
cord-269011-230p8rsf	766	5	TGEV	TGEV	NNP
cord-269011-230p8rsf	767	1	the	the	DT
cord-269011-230p8rsf	767	2	association	association	NNP
cord-269011-230p8rsf	767	3	of	of	IN
cord-269011-230p8rsf	767	4	M	M	NNP
cord-269011-230p8rsf	767	5	with	with	IN
cord-269011-230p8rsf	767	6	the	the	DT
cord-269011-230p8rsf	767	7	spherical	spherical	JJ
cord-269011-230p8rsf	767	8	structure	structure	NN
cord-269011-230p8rsf	767	9	,	,	,
cord-269011-230p8rsf	767	10	termed	term	VBD
cord-269011-230p8rsf	767	11	the	the	DT
cord-269011-230p8rsf	767	12	core	core	NN
cord-269011-230p8rsf	767	13	,	,	,
cord-269011-230p8rsf	767	14	was	be	VBD
cord-269011-230p8rsf	767	15	stabilized	stabilize	VBN
cord-269011-230p8rsf	767	16	by	by	IN
cord-269011-230p8rsf	767	17	basic	basic	JJ
cord-269011-230p8rsf	767	18	pH	ph	NN
cord-269011-230p8rsf	767	19	and	and	CC
cord-269011-230p8rsf	767	20	divalent	divalent	JJ
cord-269011-230p8rsf	767	21	cations	cation	NNS
cord-269011-230p8rsf	767	22	but	but	CC
cord-269011-230p8rsf	767	23	lost	lose	VBN
cord-269011-230p8rsf	767	24	at	at	IN
cord-269011-230p8rsf	767	25	high	high	JJ
cord-269011-230p8rsf	767	26	salt	salt	NN
cord-269011-230p8rsf	767	27	concentration	concentration	NN
cord-269011-230p8rsf	767	28	,	,	,
cord-269011-230p8rsf	767	29	resulting	result	VBG
cord-269011-230p8rsf	767	30	in	in	IN
cord-269011-230p8rsf	767	31	disruption	disruption	NN
cord-269011-230p8rsf	767	32	of	of	IN
cord-269011-230p8rsf	767	33	the	the	DT
cord-269011-230p8rsf	767	34	core	core	NN
cord-269011-230p8rsf	767	35	structure	structure	NN
cord-269011-230p8rsf	767	36	and	and	CC
cord-269011-230p8rsf	767	37	release	release	NN
cord-269011-230p8rsf	767	38	of	of	IN
cord-269011-230p8rsf	767	39	the	the	DT
cord-269011-230p8rsf	767	40	helical	helical	JJ
cord-269011-230p8rsf	767	41	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	767	42	(	(	-LRB-
cord-269011-230p8rsf	767	43	Escors	Escors	NNP
cord-269011-230p8rsf	767	44	et	et	NNP
cord-269011-230p8rsf	767	45	al	al	NNP
cord-269011-230p8rsf	767	46	.	.	NNP
cord-269011-230p8rsf	767	47	,	,	,
cord-269011-230p8rsf	767	48	2001a	2001a	CD
cord-269011-230p8rsf	767	49	,	,	,
cord-269011-230p8rsf	767	50	b	b	LS
cord-269011-230p8rsf	767	51	;	;	:
cord-269011-230p8rsf	767	52	Risco	Risco	NNP
cord-269011-230p8rsf	767	53	et	et	NNP
cord-269011-230p8rsf	767	54	al	al	NNP
cord-269011-230p8rsf	767	55	.	.	NNP
cord-269011-230p8rsf	767	56	,	,	,
cord-269011-230p8rsf	767	57	1996	1996	CD
cord-269011-230p8rsf	767	58	)	)	-RRB-
cord-269011-230p8rsf	767	59	.	.	.
cord-269011-230p8rsf	768	1	In	in	IN
cord-269011-230p8rsf	768	2	an	an	DT
cord-269011-230p8rsf	768	3	elegant	elegant	JJ
cord-269011-230p8rsf	768	4	study	study	NN
cord-269011-230p8rsf	768	5	of	of	IN
cord-269011-230p8rsf	768	6	the	the	DT
cord-269011-230p8rsf	768	7	binding	binding	NN
cord-269011-230p8rsf	768	8	of	of	IN
cord-269011-230p8rsf	768	9	in	in	IN
cord-269011-230p8rsf	768	10	vitro	vitro	FW
cord-269011-230p8rsf	768	11	-	-	HYPH
cord-269011-230p8rsf	768	12	translated	translate	VBN
cord-269011-230p8rsf	768	13	M	M	NNP
cord-269011-230p8rsf	768	14	polypeptides	polypeptide	NNS
cord-269011-230p8rsf	768	15	to	to	IN
cord-269011-230p8rsf	768	16	purified	purify	VBN
cord-269011-230p8rsf	768	17	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	768	18	the	the	DT
cord-269011-230p8rsf	768	19	ionic	ionic	JJ
cord-269011-230p8rsf	768	20	interaction	interaction	NN
cord-269011-230p8rsf	768	21	was	be	VBD
cord-269011-230p8rsf	768	22	mapped	map	VBN
cord-269011-230p8rsf	768	23	to	to	IN
cord-269011-230p8rsf	768	24	a	a	DT
cord-269011-230p8rsf	768	25	16-residue	16-residue	CD
cord-269011-230p8rsf	768	26	sequence	sequence	NN
cord-269011-230p8rsf	768	27	in	in	IN
cord-269011-230p8rsf	768	28	the	the	DT
cord-269011-230p8rsf	768	29	hydrophilic	hydrophilic	JJ
cord-269011-230p8rsf	768	30	carboxy	carboxy	JJ
cord-269011-230p8rsf	768	31	-	-	HYPH
cord-269011-230p8rsf	768	32	terminal	terminal	NN
cord-269011-230p8rsf	768	33	tail	tail	NN
cord-269011-230p8rsf	768	34	domain	domain	NN
cord-269011-230p8rsf	768	35	(	(	-LRB-
cord-269011-230p8rsf	768	36	Escors	Escors	NNP
cord-269011-230p8rsf	768	37	et	et	NNP
cord-269011-230p8rsf	768	38	al	al	NNP
cord-269011-230p8rsf	768	39	.	.	NNP
cord-269011-230p8rsf	768	40	,	,	,
cord-269011-230p8rsf	768	41	2001b	2001b	CD
cord-269011-230p8rsf	768	42	)	)	-RRB-
cord-269011-230p8rsf	768	43	.	.	.
cord-269011-230p8rsf	769	1	Also	also	RB
cord-269011-230p8rsf	769	2	in	in	IN
cord-269011-230p8rsf	769	3	infected	infected	JJ
cord-269011-230p8rsf	769	4	cells	cell	NNS
cord-269011-230p8rsf	769	5	,	,	,
cord-269011-230p8rsf	769	6	interaction	interaction	NN
cord-269011-230p8rsf	769	7	of	of	IN
cord-269011-230p8rsf	769	8	the	the	DT
cord-269011-230p8rsf	769	9	M	M	NNP
cord-269011-230p8rsf	769	10	protein	protein	NN
cord-269011-230p8rsf	769	11	with	with	IN
cord-269011-230p8rsf	769	12	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	769	13	structures	structure	NNS
cord-269011-230p8rsf	769	14	,	,	,
cord-269011-230p8rsf	769	15	presumably	presumably	RB
cord-269011-230p8rsf	769	16	nucleocapsids	nucleocapsids	NNP
cord-269011-230p8rsf	769	17	,	,	,
cord-269011-230p8rsf	769	18	has	have	VBZ
cord-269011-230p8rsf	769	19	been	be	VBN
cord-269011-230p8rsf	769	20	demonstrated	demonstrate	VBN
cord-269011-230p8rsf	769	21	.	.	.
cord-269011-230p8rsf	770	1	Using	use	VBG
cord-269011-230p8rsf	770	2	M	M	NNP
cord-269011-230p8rsf	770	3	-	-	HYPH
cord-269011-230p8rsf	770	4	specific	specific	JJ
cord-269011-230p8rsf	770	5	antibodies	antibody	NNS
cord-269011-230p8rsf	770	6	,	,	,
cord-269011-230p8rsf	770	7	structures	structure	NNS
cord-269011-230p8rsf	770	8	containing	contain	VBG
cord-269011-230p8rsf	770	9	both	both	CC
cord-269011-230p8rsf	770	10	N	n	CD
cord-269011-230p8rsf	770	11	protein	protein	NN
cord-269011-230p8rsf	770	12	and	and	CC
cord-269011-230p8rsf	770	13	genomic	genomic	JJ
cord-269011-230p8rsf	770	14	RNA	RNA	NNP
cord-269011-230p8rsf	770	15	were	be	VBD
cord-269011-230p8rsf	770	16	coimmunoprecipitated	coimmunoprecipitate	VBN
cord-269011-230p8rsf	770	17	with	with	IN
cord-269011-230p8rsf	770	18	M	M	NNP
cord-269011-230p8rsf	770	19	protein	protein	NN
cord-269011-230p8rsf	770	20	from	from	IN
cord-269011-230p8rsf	770	21	MHV	MHV	NNP
cord-269011-230p8rsf	770	22	-	-	HYPH
cord-269011-230p8rsf	770	23	infected	infect	VBN
cord-269011-230p8rsf	770	24	cell	cell	NN
cord-269011-230p8rsf	770	25	lysates	lysate	NNS
cord-269011-230p8rsf	771	1	(	(	-LRB-
cord-269011-230p8rsf	771	2	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	771	3	et	et	NNP
cord-269011-230p8rsf	771	4	al	al	NNP
cord-269011-230p8rsf	771	5	.	.	NNP
cord-269011-230p8rsf	771	6	,	,	,
cord-269011-230p8rsf	771	7	2000	2000	CD
cord-269011-230p8rsf	771	8	)	)	-RRB-
cord-269011-230p8rsf	771	9	.	.	.
cord-269011-230p8rsf	772	1	Conversely	conversely	RB
cord-269011-230p8rsf	772	2	,	,	,
cord-269011-230p8rsf	772	3	M	M	NNP
cord-269011-230p8rsf	772	4	protein	protein	NN
cord-269011-230p8rsf	772	5	was	be	VBD
cord-269011-230p8rsf	772	6	coprecipitated	coprecipitate	VBN
cord-269011-230p8rsf	772	7	when	when	WRB
cord-269011-230p8rsf	772	8	an	an	DT
cord-269011-230p8rsf	772	9	N	n	CD
cord-269011-230p8rsf	772	10	-	-	HYPH
cord-269011-230p8rsf	772	11	specific	specific	JJ
cord-269011-230p8rsf	772	12	antibody	antibody	NN
cord-269011-230p8rsf	772	13	was	be	VBD
cord-269011-230p8rsf	772	14	used	use	VBN
cord-269011-230p8rsf	772	15	,	,	,
cord-269011-230p8rsf	772	16	while	while	IN
cord-269011-230p8rsf	772	17	in	in	IN
cord-269011-230p8rsf	772	18	this	this	DT
cord-269011-230p8rsf	772	19	case	case	NN
cord-269011-230p8rsf	772	20	all	all	DT
cord-269011-230p8rsf	772	21	viral	viral	JJ
cord-269011-230p8rsf	772	22	mRNAs	mrna	VBD
cord-269011-230p8rsf	772	23	copurified	copurifie	VBN
cord-269011-230p8rsf	772	24	because	because	IN
cord-269011-230p8rsf	772	25	of	of	IN
cord-269011-230p8rsf	772	26	their	-PRON-	PRP$
cord-269011-230p8rsf	772	27	known	know	VBN
cord-269011-230p8rsf	772	28	leader	leader	NN
cord-269011-230p8rsf	772	29	-	-	HYPH
cord-269011-230p8rsf	772	30	mediated	mediate	VBN
cord-269011-230p8rsf	772	31	affinity	affinity	NN
cord-269011-230p8rsf	772	32	for	for	IN
cord-269011-230p8rsf	772	33	the	the	DT
cord-269011-230p8rsf	772	34	N	n	CD
cord-269011-230p8rsf	772	35	protein	protein	NN
cord-269011-230p8rsf	772	36	.	.	.
cord-269011-230p8rsf	773	1	These	these	DT
cord-269011-230p8rsf	773	2	interactions	interaction	NNS
cord-269011-230p8rsf	773	3	did	do	VBD
cord-269011-230p8rsf	773	4	not	not	RB
cord-269011-230p8rsf	773	5	require	require	VB
cord-269011-230p8rsf	773	6	an	an	DT
cord-269011-230p8rsf	773	7	S	s	NN
cord-269011-230p8rsf	773	8	or	or	CC
cord-269011-230p8rsf	773	9	an	an	DT
cord-269011-230p8rsf	773	10	E	e	NN
cord-269011-230p8rsf	773	11	protein	protein	NN
cord-269011-230p8rsf	773	12	(	(	-LRB-
cord-269011-230p8rsf	773	13	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	773	14	et	et	NNP
cord-269011-230p8rsf	773	15	al	al	NNP
cord-269011-230p8rsf	773	16	.	.	NNP
cord-269011-230p8rsf	773	17	,	,	,
cord-269011-230p8rsf	773	18	2000	2000	CD
cord-269011-230p8rsf	773	19	)	)	-RRB-
cord-269011-230p8rsf	773	20	.	.	.
cord-269011-230p8rsf	774	1	Although	although	IN
cord-269011-230p8rsf	774	2	interactions	interaction	NNS
cord-269011-230p8rsf	774	3	between	between	IN
cord-269011-230p8rsf	774	4	the	the	DT
cord-269011-230p8rsf	774	5	M	M	NNP
cord-269011-230p8rsf	774	6	and	and	CC
cord-269011-230p8rsf	774	7	N	n	CD
cord-269011-230p8rsf	774	8	proteins	protein	NNS
cord-269011-230p8rsf	774	9	might	may	MD
cord-269011-230p8rsf	774	10	intuitively	intuitively	RB
cord-269011-230p8rsf	774	11	be	be	VB
cord-269011-230p8rsf	774	12	expected	expect	VBN
cord-269011-230p8rsf	774	13	to	to	TO
cord-269011-230p8rsf	774	14	drive	drive	VB
cord-269011-230p8rsf	774	15	the	the	DT
cord-269011-230p8rsf	774	16	process	process	NN
cord-269011-230p8rsf	774	17	of	of	IN
cord-269011-230p8rsf	774	18	attachment	attachment	NN
cord-269011-230p8rsf	774	19	of	of	IN
cord-269011-230p8rsf	774	20	the	the	DT
cord-269011-230p8rsf	774	21	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	774	22	to	to	IN
cord-269011-230p8rsf	774	23	the	the	DT
cord-269011-230p8rsf	774	24	intracellular	intracellular	JJ
cord-269011-230p8rsf	774	25	target	target	NN
cord-269011-230p8rsf	774	26	membrane	membrane	NN
cord-269011-230p8rsf	774	27	,	,	,
cord-269011-230p8rsf	774	28	direct	direct	JJ
cord-269011-230p8rsf	774	29	experimental	experimental	JJ
cord-269011-230p8rsf	774	30	evidence	evidence	NN
cord-269011-230p8rsf	774	31	for	for	IN
cord-269011-230p8rsf	774	32	this	this	DT
cord-269011-230p8rsf	774	33	interaction	interaction	NN
cord-269011-230p8rsf	774	34	is	be	VBZ
cord-269011-230p8rsf	774	35	strikingly	strikingly	RB
cord-269011-230p8rsf	774	36	lacking	lacking	JJ
cord-269011-230p8rsf	774	37	.	.	.
cord-269011-230p8rsf	775	1	Significantly	significantly	RB
cord-269011-230p8rsf	775	2	,	,	,
cord-269011-230p8rsf	775	3	MHV	MHV	NNP
cord-269011-230p8rsf	775	4	M	M	NNP
cord-269011-230p8rsf	775	5	and	and	CC
cord-269011-230p8rsf	775	6	N	n	CD
cord-269011-230p8rsf	775	7	proteins	protein	NNS
cord-269011-230p8rsf	775	8	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	775	9	in	in	IN
cord-269011-230p8rsf	775	10	cells	cell	NNS
cord-269011-230p8rsf	775	11	were	be	VBD
cord-269011-230p8rsf	775	12	found	find	VBN
cord-269011-230p8rsf	775	13	not	not	RB
cord-269011-230p8rsf	775	14	to	to	TO
cord-269011-230p8rsf	775	15	interact	interact	VB
cord-269011-230p8rsf	775	16	(	(	-LRB-
cord-269011-230p8rsf	775	17	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	775	18	et	et	NNP
cord-269011-230p8rsf	775	19	al	al	NNP
cord-269011-230p8rsf	775	20	.	.	NNP
cord-269011-230p8rsf	775	21	,	,	,
cord-269011-230p8rsf	775	22	2000	2000	CD
cord-269011-230p8rsf	775	23	)	)	-RRB-
cord-269011-230p8rsf	775	24	nor	nor	CC
cord-269011-230p8rsf	775	25	did	do	VBD
cord-269011-230p8rsf	775	26	purified	purify	VBN
cord-269011-230p8rsf	775	27	TGEV	TGEV	NNP
cord-269011-230p8rsf	775	28	N	N	NNP
cord-269011-230p8rsf	775	29	protein	protein	NN
cord-269011-230p8rsf	775	30	interact	interact	VBP
cord-269011-230p8rsf	775	31	with	with	IN
cord-269011-230p8rsf	775	32	in	in	IN
cord-269011-230p8rsf	775	33	vitrosynthesized	vitrosynthesized	JJ
cord-269011-230p8rsf	775	34	M	M	NNP
cord-269011-230p8rsf	775	35	protein	protein	NN
cord-269011-230p8rsf	775	36	(	(	-LRB-
cord-269011-230p8rsf	775	37	Escors	Escors	NNP
cord-269011-230p8rsf	775	38	et	et	NNP
cord-269011-230p8rsf	775	39	al	al	NNP
cord-269011-230p8rsf	775	40	.	.	NNP
cord-269011-230p8rsf	775	41	,	,	,
cord-269011-230p8rsf	775	42	2001b	2001b	CD
cord-269011-230p8rsf	775	43	)	)	-RRB-
cord-269011-230p8rsf	775	44	.	.	.
cord-269011-230p8rsf	776	1	Because	because	IN
cord-269011-230p8rsf	776	2	the	the	DT
cord-269011-230p8rsf	776	3	N	N	NNP
cord-269011-230p8rsf	776	4	protein	protein	NN
cord-269011-230p8rsf	776	5	occurs	occur	VBZ
cord-269011-230p8rsf	776	6	in	in	IN
cord-269011-230p8rsf	776	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	776	8	-	-	HYPH
cord-269011-230p8rsf	776	9	infected	infect	VBN
cord-269011-230p8rsf	776	10	cells	cell	NNS
cord-269011-230p8rsf	776	11	in	in	IN
cord-269011-230p8rsf	776	12	various	various	JJ
cord-269011-230p8rsf	776	13	configurations	configuration	NNS
cord-269011-230p8rsf	776	14	-	-	:
cord-269011-230p8rsf	776	15	as	as	IN
cord-269011-230p8rsf	776	16	a	a	DT
cord-269011-230p8rsf	776	17	free	free	JJ
cord-269011-230p8rsf	776	18	protein	protein	NN
cord-269011-230p8rsf	776	19	and	and	CC
cord-269011-230p8rsf	776	20	in	in	IN
cord-269011-230p8rsf	776	21	association	association	NN
cord-269011-230p8rsf	776	22	with	with	IN
cord-269011-230p8rsf	776	23	an	an	DT
cord-269011-230p8rsf	776	24	array	array	NN
cord-269011-230p8rsf	776	25	of	of	IN
cord-269011-230p8rsf	776	26	partners	partner	NNS
cord-269011-230p8rsf	776	27	including	include	VBG
cord-269011-230p8rsf	776	28	the	the	DT
cord-269011-230p8rsf	776	29	viral	viral	JJ
cord-269011-230p8rsf	776	30	genome	genome	NN
cord-269011-230p8rsf	776	31	-	-	:
cord-269011-230p8rsf	776	32	it	-PRON-	PRP
cord-269011-230p8rsf	776	33	is	be	VBZ
cord-269011-230p8rsf	776	34	obvious	obvious	JJ
cord-269011-230p8rsf	776	35	that	that	IN
cord-269011-230p8rsf	776	36	a	a	DT
cord-269011-230p8rsf	776	37	selection	selection	NN
cord-269011-230p8rsf	776	38	mechanism	mechanism	NN
cord-269011-230p8rsf	776	39	must	must	MD
cord-269011-230p8rsf	776	40	act	act	VB
cord-269011-230p8rsf	776	41	to	to	TO
cord-269011-230p8rsf	776	42	ensure	ensure	VB
cord-269011-230p8rsf	776	43	that	that	IN
cord-269011-230p8rsf	776	44	only	only	JJ
cord-269011-230p8rsf	776	45	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	776	46	are	be	VBP
cord-269011-230p8rsf	776	47	assembled	assemble	VBN
cord-269011-230p8rsf	776	48	into	into	IN
cord-269011-230p8rsf	776	49	particles	particle	NNS
cord-269011-230p8rsf	776	50	.	.	.
cord-269011-230p8rsf	777	1	Consistently	consistently	RB
cord-269011-230p8rsf	777	2	,	,	,
cord-269011-230p8rsf	777	3	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	777	4	N	n	CD
cord-269011-230p8rsf	777	5	protein	protein	NN
cord-269011-230p8rsf	777	6	is	be	VBZ
cord-269011-230p8rsf	777	7	not	not	RB
cord-269011-230p8rsf	777	8	incorporated	incorporate	VBN
cord-269011-230p8rsf	777	9	into	into	IN
cord-269011-230p8rsf	777	10	VLPs	vlp	NNS
cord-269011-230p8rsf	777	11	,	,	,
cord-269011-230p8rsf	777	12	but	but	CC
cord-269011-230p8rsf	777	13	its	-PRON-	PRP$
cord-269011-230p8rsf	777	14	inclusion	inclusion	NN
cord-269011-230p8rsf	777	15	depends	depend	VBZ
cord-269011-230p8rsf	777	16	on	on	IN
cord-269011-230p8rsf	777	17	the	the	DT
cord-269011-230p8rsf	777	18	presence	presence	NN
cord-269011-230p8rsf	777	19	of	of	IN
cord-269011-230p8rsf	777	20	viral	viral	JJ
cord-269011-230p8rsf	777	21	RNA	RNA	NNP
cord-269011-230p8rsf	777	22	(	(	-LRB-
cord-269011-230p8rsf	777	23	Bos	Bos	NNP
cord-269011-230p8rsf	777	24	et	et	NNP
cord-269011-230p8rsf	777	25	al	al	NNP
cord-269011-230p8rsf	777	26	.	.	NNP
cord-269011-230p8rsf	777	27	,	,	,
cord-269011-230p8rsf	777	28	1996	1996	CD
cord-269011-230p8rsf	777	29	;	;	:
cord-269011-230p8rsf	777	30	Vennema	Vennema	NNP
cord-269011-230p8rsf	777	31	et	et	FW
cord-269011-230p8rsf	777	32	al	al	NNP
cord-269011-230p8rsf	777	33	.	.	NNP
cord-269011-230p8rsf	777	34	,	,	,
cord-269011-230p8rsf	777	35	1996	1996	CD
cord-269011-230p8rsf	777	36	)	)	-RRB-
cord-269011-230p8rsf	777	37	.	.	.
cord-269011-230p8rsf	778	1	Thus	thus	RB
cord-269011-230p8rsf	778	2	,	,	,
cord-269011-230p8rsf	778	3	unless	unless	IN
cord-269011-230p8rsf	778	4	the	the	DT
cord-269011-230p8rsf	778	5	selection	selection	NN
cord-269011-230p8rsf	778	6	process	process	NN
cord-269011-230p8rsf	778	7	is	be	VBZ
cord-269011-230p8rsf	778	8	performed	perform	VBN
cord-269011-230p8rsf	778	9	by	by	IN
cord-269011-230p8rsf	778	10	a	a	DT
cord-269011-230p8rsf	778	11	mechanism	mechanism	NN
cord-269011-230p8rsf	778	12	not	not	RB
cord-269011-230p8rsf	778	13	involving	involve	VBG
cord-269011-230p8rsf	778	14	the	the	DT
cord-269011-230p8rsf	778	15	N	N	NNP
cord-269011-230p8rsf	778	16	protein	protein	NN
cord-269011-230p8rsf	778	17	,	,	,
cord-269011-230p8rsf	778	18	its	-PRON-	PRP$
cord-269011-230p8rsf	778	19	association	association	NN
cord-269011-230p8rsf	778	20	with	with	IN
cord-269011-230p8rsf	778	21	genomic	genomic	NNP
cord-269011-230p8rsf	778	22	RNA	RNA	NNP
cord-269011-230p8rsf	778	23	to	to	TO
cord-269011-230p8rsf	778	24	form	form	VB
cord-269011-230p8rsf	778	25	a	a	DT
cord-269011-230p8rsf	778	26	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	778	27	seems	seem	VBZ
cord-269011-230p8rsf	778	28	required	require	VBN
cord-269011-230p8rsf	778	29	to	to	TO
cord-269011-230p8rsf	778	30	generate	generate	VB
cord-269011-230p8rsf	778	31	the	the	DT
cord-269011-230p8rsf	778	32	unique	unique	JJ
cord-269011-230p8rsf	778	33	conformation	conformation	NN
cord-269011-230p8rsf	778	34	that	that	WDT
cord-269011-230p8rsf	778	35	enables	enable	VBZ
cord-269011-230p8rsf	778	36	it	-PRON-	PRP
cord-269011-230p8rsf	778	37	to	to	TO
cord-269011-230p8rsf	778	38	interact	interact	VB
cord-269011-230p8rsf	778	39	with	with	IN
cord-269011-230p8rsf	778	40	the	the	DT
cord-269011-230p8rsf	778	41	M	M	NNP
cord-269011-230p8rsf	778	42	protein	protein	NN
cord-269011-230p8rsf	778	43	.	.	.
cord-269011-230p8rsf	779	1	The	the	DT
cord-269011-230p8rsf	779	2	only	only	JJ
cord-269011-230p8rsf	779	3	evidence	evidence	NN
cord-269011-230p8rsf	779	4	to	to	IN
cord-269011-230p8rsf	779	5	date	date	NN
cord-269011-230p8rsf	779	6	for	for	IN
cord-269011-230p8rsf	779	7	an	an	DT
cord-269011-230p8rsf	779	8	interaction	interaction	NN
cord-269011-230p8rsf	779	9	between	between	IN
cord-269011-230p8rsf	779	10	M	M	NNP
cord-269011-230p8rsf	779	11	and	and	CC
cord-269011-230p8rsf	779	12	N	n	CD
cord-269011-230p8rsf	779	13	proteins	protein	NNS
cord-269011-230p8rsf	779	14	is	be	VBZ
cord-269011-230p8rsf	779	15	indirect	indirect	JJ
cord-269011-230p8rsf	779	16	and	and	CC
cord-269011-230p8rsf	779	17	comes	come	VBZ
cord-269011-230p8rsf	779	18	from	from	IN
cord-269011-230p8rsf	779	19	genetic	genetic	JJ
cord-269011-230p8rsf	779	20	studies	study	NNS
cord-269011-230p8rsf	779	21	.	.	.
cord-269011-230p8rsf	780	1	Analysis	analysis	NN
cord-269011-230p8rsf	780	2	of	of	IN
cord-269011-230p8rsf	780	3	second	second	JJ
cord-269011-230p8rsf	780	4	-	-	HYPH
cord-269011-230p8rsf	780	5	site	site	NN
cord-269011-230p8rsf	780	6	revertants	revertant	NNS
cord-269011-230p8rsf	780	7	of	of	IN
cord-269011-230p8rsf	780	8	a	a	DT
cord-269011-230p8rsf	780	9	constructed	construct	VBN
cord-269011-230p8rsf	780	10	MHV	MHV	NNP
cord-269011-230p8rsf	780	11	-	-	HYPH
cord-269011-230p8rsf	780	12	A59	A59	NNP
cord-269011-230p8rsf	780	13	mutant	mutant	JJ
cord-269011-230p8rsf	780	14	virus	virus	NN
cord-269011-230p8rsf	780	15	lacking	lack	VBG
cord-269011-230p8rsf	780	16	the	the	DT
cord-269011-230p8rsf	780	17	two	two	CD
cord-269011-230p8rsf	780	18	carboxyterminal	carboxyterminal	JJ
cord-269011-230p8rsf	780	19	residues	residue	NNS
cord-269011-230p8rsf	780	20	of	of	IN
cord-269011-230p8rsf	780	21	its	-PRON-	PRP$
cord-269011-230p8rsf	780	22	M	M	NNP
cord-269011-230p8rsf	780	23	protein	protein	NN
cord-269011-230p8rsf	780	24	revealed	reveal	VBD
cord-269011-230p8rsf	780	25	that	that	IN
cord-269011-230p8rsf	780	26	the	the	DT
cord-269011-230p8rsf	780	27	highly	highly	RB
cord-269011-230p8rsf	780	28	defective	defective	JJ
cord-269011-230p8rsf	780	29	growth	growth	NN
cord-269011-230p8rsf	780	30	phenotype	phenotype	NN
cord-269011-230p8rsf	780	31	of	of	IN
cord-269011-230p8rsf	780	32	this	this	DT
cord-269011-230p8rsf	780	33	virus	virus	NN
cord-269011-230p8rsf	780	34	could	could	MD
cord-269011-230p8rsf	780	35	be	be	VB
cord-269011-230p8rsf	780	36	restored	restore	VBN
cord-269011-230p8rsf	780	37	,	,	,
cord-269011-230p8rsf	780	38	among	among	IN
cord-269011-230p8rsf	780	39	others	other	NNS
cord-269011-230p8rsf	780	40	,	,	,
cord-269011-230p8rsf	780	41	by	by	IN
cord-269011-230p8rsf	780	42	mutations	mutation	NNS
cord-269011-230p8rsf	780	43	in	in	IN
cord-269011-230p8rsf	780	44	the	the	DT
cord-269011-230p8rsf	780	45	carboxy	carboxy	JJ
cord-269011-230p8rsf	780	46	-	-	HYPH
cord-269011-230p8rsf	780	47	terminal	terminal	NN
cord-269011-230p8rsf	780	48	domain	domain	NN
cord-269011-230p8rsf	780	49	of	of	IN
cord-269011-230p8rsf	780	50	the	the	DT
cord-269011-230p8rsf	780	51	N	N	NNP
cord-269011-230p8rsf	780	52	protein	protein	NN
cord-269011-230p8rsf	780	53	(	(	-LRB-
cord-269011-230p8rsf	780	54	Kuo	Kuo	NNP
cord-269011-230p8rsf	780	55	and	and	CC
cord-269011-230p8rsf	780	56	Masters	Masters	NNPS
cord-269011-230p8rsf	780	57	,	,	,
cord-269011-230p8rsf	780	58	2002	2002	CD
cord-269011-230p8rsf	780	59	)	)	-RRB-
cord-269011-230p8rsf	780	60	.	.	.
cord-269011-230p8rsf	781	1	In	in	IN
cord-269011-230p8rsf	781	2	two	two	CD
cord-269011-230p8rsf	781	3	independently	independently	RB
cord-269011-230p8rsf	781	4	obtained	obtain	VBD
cord-269011-230p8rsf	781	5	revertants	revertant	NNS
cord-269011-230p8rsf	781	6	the	the	DT
cord-269011-230p8rsf	781	7	N	N	NNP
cord-269011-230p8rsf	781	8	protein	protein	NN
cord-269011-230p8rsf	781	9	had	have	VBD
cord-269011-230p8rsf	781	10	lost	lose	VBN
cord-269011-230p8rsf	781	11	15	15	CD
cord-269011-230p8rsf	781	12	residues	residue	NNS
cord-269011-230p8rsf	781	13	of	of	IN
cord-269011-230p8rsf	781	14	this	this	DT
cord-269011-230p8rsf	781	15	-	-	:
cord-269011-230p8rsf	781	16	among	among	IN
cord-269011-230p8rsf	781	17	different	different	JJ
cord-269011-230p8rsf	781	18	strains	strain	NNS
cord-269011-230p8rsf	781	19	of	of	IN
cord-269011-230p8rsf	781	20	MHV	MHV	NNP
cord-269011-230p8rsf	781	21	highly	highly	RB
cord-269011-230p8rsf	781	22	conserved	conserve	VBN
cord-269011-230p8rsf	781	23	-	-	HYPH
cord-269011-230p8rsf	781	24	domain	domain	NN
cord-269011-230p8rsf	781	25	because	because	IN
cord-269011-230p8rsf	781	26	of	of	IN
cord-269011-230p8rsf	781	27	a	a	DT
cord-269011-230p8rsf	781	28	frameshifting	frameshifte	VBG
cord-269011-230p8rsf	781	29	10-nucleotide	10-nucleotide	CD
cord-269011-230p8rsf	781	30	deletion	deletion	NN
cord-269011-230p8rsf	781	31	.	.	.
cord-269011-230p8rsf	782	1	The	the	DT
cord-269011-230p8rsf	782	2	results	result	NNS
cord-269011-230p8rsf	782	3	argue	argue	VBP
cord-269011-230p8rsf	782	4	strongly	strongly	RB
cord-269011-230p8rsf	782	5	for	for	IN
cord-269011-230p8rsf	782	6	a	a	DT
cord-269011-230p8rsf	782	7	direct	direct	JJ
cord-269011-230p8rsf	782	8	cooperation	cooperation	NN
cord-269011-230p8rsf	782	9	of	of	IN
cord-269011-230p8rsf	782	10	the	the	DT
cord-269011-230p8rsf	782	11	carboxy	carboxy	JJ
cord-269011-230p8rsf	782	12	-	-	HYPH
cord-269011-230p8rsf	782	13	terminal	terminal	NN
cord-269011-230p8rsf	782	14	regions	region	NNS
cord-269011-230p8rsf	782	15	of	of	IN
cord-269011-230p8rsf	782	16	the	the	DT
cord-269011-230p8rsf	782	17	M	M	NNP
cord-269011-230p8rsf	782	18	and	and	CC
cord-269011-230p8rsf	782	19	N	n	CD
cord-269011-230p8rsf	782	20	proteins	protein	NNS
cord-269011-230p8rsf	782	21	during	during	IN
cord-269011-230p8rsf	782	22	virion	virion	NN
cord-269011-230p8rsf	782	23	formation	formation	NN
cord-269011-230p8rsf	782	24	.	.	.
cord-269011-230p8rsf	783	1	Other	other	JJ
cord-269011-230p8rsf	783	2	indications	indication	NNS
cord-269011-230p8rsf	783	3	supporting	support	VBG
cord-269011-230p8rsf	783	4	the	the	DT
cord-269011-230p8rsf	783	5	occurrence	occurrence	NN
cord-269011-230p8rsf	783	6	of	of	IN
cord-269011-230p8rsf	783	7	M	M	NNP
cord-269011-230p8rsf	783	8	-	-	HYPH
cord-269011-230p8rsf	783	9	N	N	NNP
cord-269011-230p8rsf	783	10	interactions	interaction	NNS
cord-269011-230p8rsf	783	11	come	come	VBP
cord-269011-230p8rsf	783	12	from	from	IN
cord-269011-230p8rsf	783	13	studies	study	NNS
cord-269011-230p8rsf	783	14	of	of	IN
cord-269011-230p8rsf	783	15	complexes	complex	NNS
cord-269011-230p8rsf	783	16	of	of	IN
cord-269011-230p8rsf	783	17	M	M	NNP
cord-269011-230p8rsf	783	18	protein	protein	NN
cord-269011-230p8rsf	783	19	with	with	IN
cord-269011-230p8rsf	783	20	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	783	21	from	from	IN
cord-269011-230p8rsf	783	22	MHV	mhv	NN
cord-269011-230p8rsf	783	23	-	-	HYPH
cord-269011-230p8rsf	783	24	infected	infect	VBN
cord-269011-230p8rsf	783	25	cells	cell	NNS
cord-269011-230p8rsf	783	26	and	and	CC
cord-269011-230p8rsf	783	27	with	with	IN
cord-269011-230p8rsf	783	28	TGEV	TGEV	NNP
cord-269011-230p8rsf	783	29	cores	core	NNS
cord-269011-230p8rsf	783	30	(	(	-LRB-
cord-269011-230p8rsf	784	1	Escors	Escors	NNP
cord-269011-230p8rsf	784	2	et	et	NNP
cord-269011-230p8rsf	784	3	al	al	NNP
cord-269011-230p8rsf	784	4	.	.	.
cord-269011-230p8rsf	785	1	,	,	,
cord-269011-230p8rsf	785	2	2001b	2001b	CD
cord-269011-230p8rsf	785	3	;	;	:
cord-269011-230p8rsf	785	4	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	785	5	et	et	NNP
cord-269011-230p8rsf	785	6	al	al	NNP
cord-269011-230p8rsf	785	7	.	.	.
cord-269011-230p8rsf	786	1	,	,	,
cord-269011-230p8rsf	786	2	2000	2000	CD
cord-269011-230p8rsf	786	3	)	)	-RRB-
cord-269011-230p8rsf	786	4	.	.	.
cord-269011-230p8rsf	787	1	When	when	WRB
cord-269011-230p8rsf	787	2	such	such	JJ
cord-269011-230p8rsf	787	3	complexes	complex	NNS
cord-269011-230p8rsf	787	4	were	be	VBD
cord-269011-230p8rsf	787	5	treated	treat	VBN
cord-269011-230p8rsf	787	6	with	with	IN
cord-269011-230p8rsf	787	7	RNase	RNase	NNP
cord-269011-230p8rsf	787	8	the	the	DT
cord-269011-230p8rsf	787	9	association	association	NN
cord-269011-230p8rsf	787	10	of	of	IN
cord-269011-230p8rsf	787	11	M	M	NNP
cord-269011-230p8rsf	787	12	and	and	CC
cord-269011-230p8rsf	787	13	N	n	CD
cord-269011-230p8rsf	787	14	proteins	protein	NNS
cord-269011-230p8rsf	787	15	was	be	VBD
cord-269011-230p8rsf	787	16	not	not	RB
cord-269011-230p8rsf	787	17	destroyed	destroy	VBN
cord-269011-230p8rsf	787	18	,	,	,
cord-269011-230p8rsf	787	19	suggesting	suggest	VBG
cord-269011-230p8rsf	787	20	a	a	DT
cord-269011-230p8rsf	787	21	direct	direct	JJ
cord-269011-230p8rsf	787	22	interaction	interaction	NN
cord-269011-230p8rsf	787	23	.	.	.
cord-269011-230p8rsf	788	1	However	however	RB
cord-269011-230p8rsf	788	2	,	,	,
cord-269011-230p8rsf	788	3	the	the	DT
cord-269011-230p8rsf	788	4	presence	presence	NN
cord-269011-230p8rsf	788	5	of	of	IN
cord-269011-230p8rsf	788	6	short	short	JJ
cord-269011-230p8rsf	788	7	RNAs	rna	NNS
cord-269011-230p8rsf	788	8	inaccessible	inaccessible	JJ
cord-269011-230p8rsf	788	9	to	to	IN
cord-269011-230p8rsf	788	10	the	the	DT
cord-269011-230p8rsf	788	11	RNase	rnase	NN
cord-269011-230p8rsf	788	12	but	but	CC
cord-269011-230p8rsf	788	13	sufficient	sufficient	JJ
cord-269011-230p8rsf	788	14	to	to	TO
cord-269011-230p8rsf	788	15	bridge	bridge	VB
cord-269011-230p8rsf	788	16	the	the	DT
cord-269011-230p8rsf	788	17	M	M	NNP
cord-269011-230p8rsf	788	18	-	-	HYPH
cord-269011-230p8rsf	788	19	N	N	NNP
cord-269011-230p8rsf	788	20	interaction	interaction	NN
cord-269011-230p8rsf	788	21	could	could	MD
cord-269011-230p8rsf	788	22	not	not	RB
cord-269011-230p8rsf	788	23	be	be	VB
cord-269011-230p8rsf	788	24	excluded	exclude	VBN
cord-269011-230p8rsf	788	25	.	.	.
cord-269011-230p8rsf	789	1	The	the	DT
cord-269011-230p8rsf	789	2	most	most	RBS
cord-269011-230p8rsf	789	3	unusual	unusual	JJ
cord-269011-230p8rsf	789	4	interaction	interaction	NN
cord-269011-230p8rsf	789	5	that	that	WDT
cord-269011-230p8rsf	789	6	the	the	DT
cord-269011-230p8rsf	789	7	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	789	8	M	M	NNP
cord-269011-230p8rsf	789	9	protein	protein	NN
cord-269011-230p8rsf	789	10	seems	seem	VBZ
cord-269011-230p8rsf	789	11	to	to	TO
cord-269011-230p8rsf	789	12	engage	engage	VB
cord-269011-230p8rsf	789	13	in	in	IN
cord-269011-230p8rsf	789	14	involves	involve	VBZ
cord-269011-230p8rsf	789	15	genomic	genomic	JJ
cord-269011-230p8rsf	789	16	RNA	RNA	NNP
cord-269011-230p8rsf	789	17	.	.	.
cord-269011-230p8rsf	790	1	This	this	DT
cord-269011-230p8rsf	790	2	interaction	interaction	NN
cord-269011-230p8rsf	790	3	has	have	VBZ
cord-269011-230p8rsf	790	4	so	so	RB
cord-269011-230p8rsf	790	5	far	far	RB
cord-269011-230p8rsf	790	6	been	be	VBN
cord-269011-230p8rsf	790	7	reported	report	VBN
cord-269011-230p8rsf	790	8	only	only	RB
cord-269011-230p8rsf	790	9	for	for	IN
cord-269011-230p8rsf	790	10	MHV	MHV	NNP
cord-269011-230p8rsf	790	11	,	,	,
cord-269011-230p8rsf	790	12	by	by	IN
cord-269011-230p8rsf	790	13	Makino	Makino	NNP
cord-269011-230p8rsf	790	14	and	and	CC
cord-269011-230p8rsf	790	15	co	co	NNS
cord-269011-230p8rsf	790	16	-	-	NNS
cord-269011-230p8rsf	790	17	workers	worker	NNS
cord-269011-230p8rsf	790	18	.	.	.
cord-269011-230p8rsf	791	1	These	these	DT
cord-269011-230p8rsf	791	2	workers	worker	NNS
cord-269011-230p8rsf	791	3	had	have	VBD
cord-269011-230p8rsf	791	4	shown	show	VBN
cord-269011-230p8rsf	791	5	earlier	early	RBR
cord-269011-230p8rsf	791	6	that	that	IN
cord-269011-230p8rsf	791	7	the	the	DT
cord-269011-230p8rsf	791	8	69-nucleotide	69-nucleotide	CD
cord-269011-230p8rsf	791	9	packaging	packaging	NN
cord-269011-230p8rsf	791	10	signal	signal	NN
cord-269011-230p8rsf	791	11	located	locate	VBN
cord-269011-230p8rsf	791	12	in	in	IN
cord-269011-230p8rsf	791	13	the	the	DT
cord-269011-230p8rsf	791	14	pol1b	pol1b	JJ
cord-269011-230p8rsf	791	15	gene	gene	NN
cord-269011-230p8rsf	791	16	could	could	MD
cord-269011-230p8rsf	791	17	mediate	mediate	VB
cord-269011-230p8rsf	791	18	the	the	DT
cord-269011-230p8rsf	791	19	incorporation	incorporation	NN
cord-269011-230p8rsf	791	20	into	into	IN
cord-269011-230p8rsf	791	21	virions	virion	NNS
cord-269011-230p8rsf	791	22	of	of	IN
cord-269011-230p8rsf	791	23	RNAs	rna	NNS
cord-269011-230p8rsf	791	24	of	of	IN
cord-269011-230p8rsf	791	25	even	even	RB
cord-269011-230p8rsf	791	26	noncoronaviral	noncoronaviral	JJ
cord-269011-230p8rsf	791	27	origin	origin	NN
cord-269011-230p8rsf	792	1	(	(	-LRB-
cord-269011-230p8rsf	792	2	Woo	woo	UH
cord-269011-230p8rsf	792	3	et	et	FW
cord-269011-230p8rsf	792	4	al	al	NNP
cord-269011-230p8rsf	792	5	.	.	NNP
cord-269011-230p8rsf	792	6	,	,	,
cord-269011-230p8rsf	792	7	1997	1997	CD
cord-269011-230p8rsf	792	8	)	)	-RRB-
cord-269011-230p8rsf	792	9	.	.	.
cord-269011-230p8rsf	793	1	They	-PRON-	PRP
cord-269011-230p8rsf	793	2	subsequently	subsequently	RB
cord-269011-230p8rsf	793	3	showed	show	VBD
cord-269011-230p8rsf	793	4	that	that	IN
cord-269011-230p8rsf	793	5	this	this	DT
cord-269011-230p8rsf	793	6	incorporation	incorporation	NN
cord-269011-230p8rsf	793	7	is	be	VBZ
cord-269011-230p8rsf	793	8	most	most	RBS
cord-269011-230p8rsf	793	9	likely	likely	RB
cord-269011-230p8rsf	793	10	effected	effect	VBN
cord-269011-230p8rsf	793	11	by	by	IN
cord-269011-230p8rsf	793	12	a	a	DT
cord-269011-230p8rsf	793	13	direct	direct	JJ
cord-269011-230p8rsf	793	14	and	and	CC
cord-269011-230p8rsf	793	15	specific	specific	JJ
cord-269011-230p8rsf	793	16	interaction	interaction	NN
cord-269011-230p8rsf	793	17	of	of	IN
cord-269011-230p8rsf	793	18	the	the	DT
cord-269011-230p8rsf	793	19	signal	signal	NN
cord-269011-230p8rsf	793	20	with	with	IN
cord-269011-230p8rsf	793	21	the	the	DT
cord-269011-230p8rsf	793	22	M	M	NNP
cord-269011-230p8rsf	793	23	protein	protein	NN
cord-269011-230p8rsf	793	24	.	.	.
cord-269011-230p8rsf	794	1	When	when	WRB
cord-269011-230p8rsf	794	2	defective	defective	JJ
cord-269011-230p8rsf	794	3	genomic	genomic	JJ
cord-269011-230p8rsf	794	4	RNAs	rna	NNS
cord-269011-230p8rsf	794	5	or	or	CC
cord-269011-230p8rsf	794	6	nonviral	nonviral	JJ
cord-269011-230p8rsf	794	7	RNAs	rna	NNS
cord-269011-230p8rsf	794	8	were	be	VBD
cord-269011-230p8rsf	794	9	introduced	introduce	VBN
cord-269011-230p8rsf	794	10	into	into	IN
cord-269011-230p8rsf	794	11	helper	helper	NN
cord-269011-230p8rsf	794	12	MHV	mhv	NN
cord-269011-230p8rsf	794	13	-	-	HYPH
cord-269011-230p8rsf	794	14	infected	infect	VBN
cord-269011-230p8rsf	794	15	cells	cell	NNS
cord-269011-230p8rsf	794	16	,	,	,
cord-269011-230p8rsf	794	17	they	-PRON-	PRP
cord-269011-230p8rsf	794	18	could	could	MD
cord-269011-230p8rsf	794	19	subsequently	subsequently	RB
cord-269011-230p8rsf	794	20	be	be	VB
cord-269011-230p8rsf	794	21	isolated	isolate	VBN
cord-269011-230p8rsf	794	22	as	as	IN
cord-269011-230p8rsf	794	23	ribonucleoproteins	ribonucleoprotein	NNS
cord-269011-230p8rsf	794	24	from	from	IN
cord-269011-230p8rsf	794	25	lysates	lysate	NNS
cord-269011-230p8rsf	794	26	of	of	IN
cord-269011-230p8rsf	794	27	the	the	DT
cord-269011-230p8rsf	794	28	cells	cell	NNS
cord-269011-230p8rsf	794	29	by	by	IN
cord-269011-230p8rsf	794	30	immunoprecipitation	immunoprecipitation	NN
cord-269011-230p8rsf	794	31	with	with	IN
cord-269011-230p8rsf	794	32	an	an	DT
cord-269011-230p8rsf	794	33	M	M	NNP
cord-269011-230p8rsf	794	34	-	-	HYPH
cord-269011-230p8rsf	794	35	specific	specific	JJ
cord-269011-230p8rsf	794	36	antibody	antibody	NN
cord-269011-230p8rsf	794	37	,	,	,
cord-269011-230p8rsf	794	38	but	but	CC
cord-269011-230p8rsf	794	39	only	only	RB
cord-269011-230p8rsf	794	40	if	if	IN
cord-269011-230p8rsf	794	41	the	the	DT
cord-269011-230p8rsf	794	42	RNAs	rna	NNS
cord-269011-230p8rsf	794	43	contained	contain	VBD
cord-269011-230p8rsf	794	44	the	the	DT
cord-269011-230p8rsf	794	45	packaging	packaging	NN
cord-269011-230p8rsf	794	46	signal	signal	NN
cord-269011-230p8rsf	794	47	(	(	-LRB-
cord-269011-230p8rsf	794	48	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	794	49	and	and	CC
cord-269011-230p8rsf	794	50	Makino	Makino	NNP
cord-269011-230p8rsf	794	51	,	,	,
cord-269011-230p8rsf	794	52	2001	2001	CD
cord-269011-230p8rsf	794	53	)	)	-RRB-
cord-269011-230p8rsf	794	54	.	.	.
cord-269011-230p8rsf	795	1	Coexpression	coexpression	NN
cord-269011-230p8rsf	795	2	experiments	experiment	NNS
cord-269011-230p8rsf	795	3	using	use	VBG
cord-269011-230p8rsf	795	4	noncoronaviral	noncoronaviral	JJ
cord-269011-230p8rsf	795	5	vectors	vector	NNS
cord-269011-230p8rsf	795	6	showed	show	VBD
cord-269011-230p8rsf	795	7	the	the	DT
cord-269011-230p8rsf	795	8	interaction	interaction	NN
cord-269011-230p8rsf	795	9	to	to	TO
cord-269011-230p8rsf	795	10	be	be	VB
cord-269011-230p8rsf	795	11	independent	independent	JJ
cord-269011-230p8rsf	795	12	of	of	IN
cord-269011-230p8rsf	795	13	the	the	DT
cord-269011-230p8rsf	795	14	N	N	NNP
cord-269011-230p8rsf	795	15	protein	protein	NN
cord-269011-230p8rsf	795	16	.	.	.
cord-269011-230p8rsf	796	1	A	a	DT
cord-269011-230p8rsf	796	2	reporter	reporter	NN
cord-269011-230p8rsf	796	3	gene	gene	NN
cord-269011-230p8rsf	796	4	transcript	transcript	NN
cord-269011-230p8rsf	796	5	generated	generate	VBN
cord-269011-230p8rsf	796	6	in	in	IN
cord-269011-230p8rsf	796	7	cells	cell	NNS
cord-269011-230p8rsf	796	8	expressing	express	VBG
cord-269011-230p8rsf	796	9	the	the	DT
cord-269011-230p8rsf	796	10	M	M	NNP
cord-269011-230p8rsf	796	11	protein	protein	NN
cord-269011-230p8rsf	796	12	could	could	MD
cord-269011-230p8rsf	796	13	be	be	VB
cord-269011-230p8rsf	796	14	coimmunoprecipitated	coimmunoprecipitate	VBN
cord-269011-230p8rsf	796	15	with	with	IN
cord-269011-230p8rsf	796	16	an	an	DT
cord-269011-230p8rsf	796	17	anti	anti	JJ
cord-269011-230p8rsf	796	18	-	-	JJ
cord-269011-230p8rsf	796	19	M	m	JJ
cord-269011-230p8rsf	796	20	monoclonal	monoclonal	JJ
cord-269011-230p8rsf	796	21	antibody	antibody	NN
cord-269011-230p8rsf	796	22	provided	provide	VBD
cord-269011-230p8rsf	796	23	that	that	IN
cord-269011-230p8rsf	796	24	the	the	DT
cord-269011-230p8rsf	796	25	RNA	RNA	NNP
cord-269011-230p8rsf	796	26	carried	carry	VBD
cord-269011-230p8rsf	796	27	the	the	DT
cord-269011-230p8rsf	796	28	packaging	packaging	NN
cord-269011-230p8rsf	796	29	signal	signal	NN
cord-269011-230p8rsf	796	30	(	(	-LRB-
cord-269011-230p8rsf	796	31	Narayanan	Narayanan	NNP
cord-269011-230p8rsf	796	32	et	et	NNP
cord-269011-230p8rsf	796	33	al	al	NNP
cord-269011-230p8rsf	796	34	.	.	NNP
cord-269011-230p8rsf	796	35	,	,	,
cord-269011-230p8rsf	796	36	2003a	2003a	CD
cord-269011-230p8rsf	796	37	)	)	-RRB-
cord-269011-230p8rsf	796	38	.	.	.
cord-269011-230p8rsf	797	1	Moreover	moreover	RB
cord-269011-230p8rsf	797	2	,	,	,
cord-269011-230p8rsf	797	3	when	when	WRB
cord-269011-230p8rsf	797	4	the	the	DT
cord-269011-230p8rsf	797	5	E	e	NN
cord-269011-230p8rsf	797	6	protein	protein	NN
cord-269011-230p8rsf	797	7	was	be	VBD
cord-269011-230p8rsf	797	8	additionally	additionally	RB
cord-269011-230p8rsf	797	9	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	797	10	,	,	,
cord-269011-230p8rsf	797	11	the	the	DT
cord-269011-230p8rsf	797	12	signal	signal	NN
cord-269011-230p8rsf	797	13	-	-	HYPH
cord-269011-230p8rsf	797	14	containing	contain	VBG
cord-269011-230p8rsf	797	15	RNA	rna	NN
cord-269011-230p8rsf	797	16	-	-	:
cord-269011-230p8rsf	797	17	but	but	CC
cord-269011-230p8rsf	797	18	not	not	RB
cord-269011-230p8rsf	797	19	an	an	DT
cord-269011-230p8rsf	797	20	identical	identical	JJ
cord-269011-230p8rsf	797	21	RNA	rna	NN
cord-269011-230p8rsf	797	22	lacking	lack	VBG
cord-269011-230p8rsf	797	23	this	this	DT
cord-269011-230p8rsf	797	24	sequence	sequence	NN
cord-269011-230p8rsf	797	25	-	-	:
cord-269011-230p8rsf	797	26	was	be	VBD
cord-269011-230p8rsf	797	27	found	find	VBN
cord-269011-230p8rsf	797	28	to	to	TO
cord-269011-230p8rsf	797	29	be	be	VB
cord-269011-230p8rsf	797	30	coincorporated	coincorporate	VBN
cord-269011-230p8rsf	797	31	into	into	IN
cord-269011-230p8rsf	797	32	VLPs	vlp	NNS
cord-269011-230p8rsf	797	33	,	,	,
cord-269011-230p8rsf	797	34	irrespective	irrespective	RB
cord-269011-230p8rsf	797	35	of	of	IN
cord-269011-230p8rsf	797	36	the	the	DT
cord-269011-230p8rsf	797	37	presence	presence	NN
cord-269011-230p8rsf	797	38	of	of	IN
cord-269011-230p8rsf	797	39	the	the	DT
cord-269011-230p8rsf	797	40	N	N	NNP
cord-269011-230p8rsf	797	41	protein	protein	NN
cord-269011-230p8rsf	797	42	.	.	.
cord-269011-230p8rsf	798	1	Altogether	altogether	RB
cord-269011-230p8rsf	798	2	these	these	DT
cord-269011-230p8rsf	798	3	observations	observation	NNS
cord-269011-230p8rsf	798	4	reveal	reveal	VBP
cord-269011-230p8rsf	798	5	a	a	DT
cord-269011-230p8rsf	798	6	hitherto	hitherto	RB
cord-269011-230p8rsf	798	7	unknown	unknown	JJ
cord-269011-230p8rsf	798	8	type	type	NN
cord-269011-230p8rsf	798	9	of	of	IN
cord-269011-230p8rsf	798	10	interaction	interaction	NN
cord-269011-230p8rsf	798	11	between	between	IN
cord-269011-230p8rsf	798	12	a	a	DT
cord-269011-230p8rsf	798	13	viral	viral	JJ
cord-269011-230p8rsf	798	14	envelope	envelope	NN
cord-269011-230p8rsf	798	15	protein	protein	NN
cord-269011-230p8rsf	798	16	and	and	CC
cord-269011-230p8rsf	798	17	genomic	genomic	JJ
cord-269011-230p8rsf	798	18	RNA	RNA	NNP
cord-269011-230p8rsf	798	19	.	.	.
cord-269011-230p8rsf	799	1	Although	although	IN
cord-269011-230p8rsf	799	2	its	-PRON-	PRP$
cord-269011-230p8rsf	799	3	significance	significance	NN
cord-269011-230p8rsf	799	4	remains	remain	VBZ
cord-269011-230p8rsf	799	5	to	to	TO
cord-269011-230p8rsf	799	6	be	be	VB
cord-269011-230p8rsf	799	7	further	further	RB
cord-269011-230p8rsf	799	8	established	establish	VBN
cord-269011-230p8rsf	799	9	the	the	DT
cord-269011-230p8rsf	799	10	M	M	NNP
cord-269011-230p8rsf	799	11	-	-	HYPH
cord-269011-230p8rsf	799	12	RNA	RNA	NNP
cord-269011-230p8rsf	799	13	interaction	interaction	NN
cord-269011-230p8rsf	799	14	seems	seem	VBZ
cord-269011-230p8rsf	799	15	to	to	TO
cord-269011-230p8rsf	799	16	provide	provide	VB
cord-269011-230p8rsf	799	17	additional	additional	JJ
cord-269011-230p8rsf	799	18	selectivity	selectivity	NN
cord-269011-230p8rsf	799	19	to	to	IN
cord-269011-230p8rsf	799	20	the	the	DT
cord-269011-230p8rsf	799	21	assembly	assembly	NN
cord-269011-230p8rsf	799	22	of	of	IN
cord-269011-230p8rsf	799	23	the	the	DT
cord-269011-230p8rsf	799	24	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	799	25	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	799	26	.	.	.
cord-269011-230p8rsf	800	1	Assembly	assembly	NN
cord-269011-230p8rsf	800	2	of	of	IN
cord-269011-230p8rsf	800	3	viruses	virus	NNS
cord-269011-230p8rsf	800	4	is	be	VBZ
cord-269011-230p8rsf	800	5	a	a	DT
cord-269011-230p8rsf	800	6	process	process	NN
cord-269011-230p8rsf	800	7	of	of	IN
cord-269011-230p8rsf	800	8	generally	generally	RB
cord-269011-230p8rsf	800	9	high	high	JJ
cord-269011-230p8rsf	800	10	specificity	specificity	NN
cord-269011-230p8rsf	800	11	.	.	.
cord-269011-230p8rsf	801	1	Directed	direct	VBN
cord-269011-230p8rsf	801	2	by	by	IN
cord-269011-230p8rsf	801	3	specific	specific	JJ
cord-269011-230p8rsf	801	4	targeting	targeting	NN
cord-269011-230p8rsf	801	5	signals	signal	NNS
cord-269011-230p8rsf	801	6	,	,	,
cord-269011-230p8rsf	801	7	the	the	DT
cord-269011-230p8rsf	801	8	viral	viral	JJ
cord-269011-230p8rsf	801	9	structural	structural	JJ
cord-269011-230p8rsf	801	10	components	component	NNS
cord-269011-230p8rsf	801	11	colocalize	colocalize	NN
cord-269011-230p8rsf	801	12	to	to	IN
cord-269011-230p8rsf	801	13	distinct	distinct	JJ
cord-269011-230p8rsf	801	14	places	place	NNS
cord-269011-230p8rsf	801	15	in	in	IN
cord-269011-230p8rsf	801	16	the	the	DT
cord-269011-230p8rsf	801	17	cell	cell	NN
cord-269011-230p8rsf	801	18	where	where	WRB
cord-269011-230p8rsf	801	19	unique	unique	JJ
cord-269011-230p8rsf	801	20	and	and	CC
cord-269011-230p8rsf	801	21	complex	complex	JJ
cord-269011-230p8rsf	801	22	molecular	molecular	JJ
cord-269011-230p8rsf	801	23	interactions	interaction	NNS
cord-269011-230p8rsf	801	24	control	control	VBP
cord-269011-230p8rsf	801	25	their	-PRON-	PRP$
cord-269011-230p8rsf	801	26	assembly	assembly	NN
cord-269011-230p8rsf	801	27	.	.	.
cord-269011-230p8rsf	802	1	These	these	DT
cord-269011-230p8rsf	802	2	rules	rule	NNS
cord-269011-230p8rsf	802	3	hold	hold	VBP
cord-269011-230p8rsf	802	4	particularly	particularly	RB
cord-269011-230p8rsf	802	5	for	for	IN
cord-269011-230p8rsf	802	6	naked	naked	JJ
cord-269011-230p8rsf	802	7	viruses	virus	NNS
cord-269011-230p8rsf	802	8	and	and	CC
cord-269011-230p8rsf	802	9	many	many	JJ
cord-269011-230p8rsf	802	10	of	of	IN
cord-269011-230p8rsf	802	11	the	the	DT
cord-269011-230p8rsf	802	12	smaller	small	JJR
cord-269011-230p8rsf	802	13	enveloped	envelop	VBN
cord-269011-230p8rsf	802	14	viruses	virus	NNS
cord-269011-230p8rsf	802	15	;	;	:
cord-269011-230p8rsf	802	16	there	there	EX
cord-269011-230p8rsf	802	17	are	be	VBP
cord-269011-230p8rsf	802	18	,	,	,
cord-269011-230p8rsf	802	19	however	however	RB
cord-269011-230p8rsf	802	20	,	,	,
cord-269011-230p8rsf	802	21	many	many	JJ
cord-269011-230p8rsf	802	22	examples	example	NNS
cord-269011-230p8rsf	802	23	where	where	WRB
cord-269011-230p8rsf	802	24	the	the	DT
cord-269011-230p8rsf	802	25	process	process	NN
cord-269011-230p8rsf	802	26	is	be	VBZ
cord-269011-230p8rsf	802	27	considerably	considerably	RB
cord-269011-230p8rsf	802	28	less	less	RBR
cord-269011-230p8rsf	802	29	selective	selective	JJ
cord-269011-230p8rsf	802	30	and	and	CC
cord-269011-230p8rsf	802	31	where	where	WRB
cord-269011-230p8rsf	802	32	"	"	``
cord-269011-230p8rsf	802	33	nonself	nonself	NN
cord-269011-230p8rsf	802	34	"	"	''
cord-269011-230p8rsf	802	35	(	(	-LRB-
cord-269011-230p8rsf	802	36	host	host	NN
cord-269011-230p8rsf	802	37	or	or	CC
cord-269011-230p8rsf	802	38	viral	viral	JJ
cord-269011-230p8rsf	802	39	)	)	-RRB-
cord-269011-230p8rsf	802	40	components	component	NNS
cord-269011-230p8rsf	802	41	are	be	VBP
cord-269011-230p8rsf	802	42	coassembled	coassemble	VBN
cord-269011-230p8rsf	802	43	(	(	-LRB-
cord-269011-230p8rsf	802	44	see	see	VB
cord-269011-230p8rsf	802	45	,	,	,
cord-269011-230p8rsf	802	46	e.g.	e.g.	RB
cord-269011-230p8rsf	802	47	,	,	,
cord-269011-230p8rsf	802	48	Garoff	Garoff	NNP
cord-269011-230p8rsf	802	49	et	et	NNP
cord-269011-230p8rsf	802	50	al	al	NNP
cord-269011-230p8rsf	802	51	.	.	NNP
cord-269011-230p8rsf	802	52	,	,	,
cord-269011-230p8rsf	802	53	1998	1998	CD
cord-269011-230p8rsf	802	54	)	)	-RRB-
cord-269011-230p8rsf	802	55	.	.	.
cord-269011-230p8rsf	803	1	Interestingly	interestingly	RB
cord-269011-230p8rsf	803	2	,	,	,
cord-269011-230p8rsf	803	3	formation	formation	NN
cord-269011-230p8rsf	803	4	of	of	IN
cord-269011-230p8rsf	803	5	the	the	DT
cord-269011-230p8rsf	803	6	large	large	JJ
cord-269011-230p8rsf	803	7	,	,	,
cord-269011-230p8rsf	803	8	pleiomorphic	pleiomorphic	JJ
cord-269011-230p8rsf	803	9	coronaviruses	coronaviruses	NNP
cord-269011-230p8rsf	803	10	appears	appear	VBZ
cord-269011-230p8rsf	803	11	to	to	TO
cord-269011-230p8rsf	803	12	combine	combine	VB
cord-269011-230p8rsf	803	13	aspects	aspect	NNS
cord-269011-230p8rsf	803	14	of	of	IN
cord-269011-230p8rsf	803	15	both	both	DT
cord-269011-230p8rsf	803	16	great	great	JJ
cord-269011-230p8rsf	803	17	selectivity	selectivity	NN
cord-269011-230p8rsf	803	18	and	and	CC
cord-269011-230p8rsf	803	19	extreme	extreme	JJ
cord-269011-230p8rsf	803	20	flexibility	flexibility	NN
cord-269011-230p8rsf	803	21	.	.	.
cord-269011-230p8rsf	804	1	With	with	IN
cord-269011-230p8rsf	804	2	the	the	DT
cord-269011-230p8rsf	804	3	M	M	NNP
cord-269011-230p8rsf	804	4	and	and	CC
cord-269011-230p8rsf	804	5	E	e	NN
cord-269011-230p8rsf	804	6	proteins	protein	NNS
cord-269011-230p8rsf	804	7	as	as	IN
cord-269011-230p8rsf	804	8	the	the	DT
cord-269011-230p8rsf	804	9	fixed	fix	VBN
cord-269011-230p8rsf	804	10	minimal	minimal	JJ
cord-269011-230p8rsf	804	11	requirement	requirement	NN
cord-269011-230p8rsf	804	12	,	,	,
cord-269011-230p8rsf	804	13	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	804	14	particles	particle	NNS
cord-269011-230p8rsf	804	15	appear	appear	VBP
cord-269011-230p8rsf	804	16	to	to	TO
cord-269011-230p8rsf	804	17	tolerate	tolerate	VB
cord-269011-230p8rsf	804	18	the	the	DT
cord-269011-230p8rsf	804	19	presence	presence	NN
cord-269011-230p8rsf	804	20	of	of	IN
cord-269011-230p8rsf	804	21	all	all	DT
cord-269011-230p8rsf	804	22	other	other	JJ
cord-269011-230p8rsf	804	23	viral	viral	JJ
cord-269011-230p8rsf	804	24	components	component	NNS
cord-269011-230p8rsf	804	25	in	in	IN
cord-269011-230p8rsf	804	26	practically	practically	RB
cord-269011-230p8rsf	804	27	every	every	DT
cord-269011-230p8rsf	804	28	possible	possible	JJ
cord-269011-230p8rsf	804	29	combination	combination	NN
cord-269011-230p8rsf	804	30	.	.	.
cord-269011-230p8rsf	805	1	A	a	DT
cord-269011-230p8rsf	805	2	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	805	3	is	be	VBZ
cord-269011-230p8rsf	805	4	not	not	RB
cord-269011-230p8rsf	805	5	required	require	VBN
cord-269011-230p8rsf	805	6	but	but	CC
cord-269011-230p8rsf	805	7	,	,	,
cord-269011-230p8rsf	805	8	if	if	IN
cord-269011-230p8rsf	805	9	available	available	JJ
cord-269011-230p8rsf	805	10	,	,	,
cord-269011-230p8rsf	805	11	it	-PRON-	PRP
cord-269011-230p8rsf	805	12	can	can	MD
cord-269011-230p8rsf	805	13	take	take	VB
cord-269011-230p8rsf	805	14	almost	almost	RB
cord-269011-230p8rsf	805	15	any	any	DT
cord-269011-230p8rsf	805	16	length	length	NN
cord-269011-230p8rsf	805	17	as	as	IN
cord-269011-230p8rsf	805	18	defective	defective	JJ
cord-269011-230p8rsf	805	19	(	(	-LRB-
cord-269011-230p8rsf	805	20	including	include	VBG
cord-269011-230p8rsf	805	21	chimeric	chimeric	JJ
cord-269011-230p8rsf	805	22	)	)	-RRB-
cord-269011-230p8rsf	805	23	genomes	genome	NNS
cord-269011-230p8rsf	805	24	of	of	IN
cord-269011-230p8rsf	805	25	largely	largely	RB
cord-269011-230p8rsf	805	26	varying	vary	VBG
cord-269011-230p8rsf	805	27	sizes	size	NNS
cord-269011-230p8rsf	805	28	have	have	VBP
cord-269011-230p8rsf	805	29	been	be	VBN
cord-269011-230p8rsf	805	30	accommodated	accommodate	VBN
cord-269011-230p8rsf	805	31	.	.	.
cord-269011-230p8rsf	806	1	RNAs	rna	NNS
cord-269011-230p8rsf	806	2	need	need	VBP
cord-269011-230p8rsf	806	3	not	not	RB
cord-269011-230p8rsf	806	4	necessarily	necessarily	RB
cord-269011-230p8rsf	806	5	be	be	VB
cord-269011-230p8rsf	806	6	packaged	package	VBN
cord-269011-230p8rsf	806	7	into	into	IN
cord-269011-230p8rsf	806	8	a	a	DT
cord-269011-230p8rsf	806	9	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	806	10	;	;	:
cord-269011-230p8rsf	806	11	whether	whether	IN
cord-269011-230p8rsf	806	12	of	of	IN
cord-269011-230p8rsf	806	13	viral	viral	JJ
cord-269011-230p8rsf	806	14	or	or	CC
cord-269011-230p8rsf	806	15	nonviral	nonviral	JJ
cord-269011-230p8rsf	806	16	origin	origin	NN
cord-269011-230p8rsf	806	17	,	,	,
cord-269011-230p8rsf	806	18	if	if	IN
cord-269011-230p8rsf	806	19	provided	provide	VBN
cord-269011-230p8rsf	806	20	with	with	IN
cord-269011-230p8rsf	806	21	the	the	DT
cord-269011-230p8rsf	806	22	proper	proper	JJ
cord-269011-230p8rsf	806	23	packaging	packaging	NN
cord-269011-230p8rsf	806	24	signal	signal	NN
cord-269011-230p8rsf	806	25	they	-PRON-	PRP
cord-269011-230p8rsf	806	26	can	can	MD
cord-269011-230p8rsf	806	27	be	be	VB
cord-269011-230p8rsf	806	28	taken	take	VBN
cord-269011-230p8rsf	806	29	in	in	RP
cord-269011-230p8rsf	806	30	even	even	RB
cord-269011-230p8rsf	806	31	in	in	IN
cord-269011-230p8rsf	806	32	the	the	DT
cord-269011-230p8rsf	806	33	absence	absence	NN
cord-269011-230p8rsf	806	34	of	of	IN
cord-269011-230p8rsf	806	35	an	an	DT
cord-269011-230p8rsf	806	36	N	n	CD
cord-269011-230p8rsf	806	37	protein	protein	NN
cord-269011-230p8rsf	806	38	.	.	.
cord-269011-230p8rsf	807	1	Also	also	RB
cord-269011-230p8rsf	807	2	in	in	IN
cord-269011-230p8rsf	807	3	the	the	DT
cord-269011-230p8rsf	807	4	composition	composition	NN
cord-269011-230p8rsf	807	5	of	of	IN
cord-269011-230p8rsf	807	6	their	-PRON-	PRP$
cord-269011-230p8rsf	807	7	viral	viral	JJ
cord-269011-230p8rsf	807	8	envelope	envelope	NN
cord-269011-230p8rsf	807	9	these	these	DT
cord-269011-230p8rsf	807	10	viruses	virus	NNS
cord-269011-230p8rsf	807	11	are	be	VBP
cord-269011-230p8rsf	807	12	highly	highly	RB
cord-269011-230p8rsf	807	13	flexible	flexible	JJ
cord-269011-230p8rsf	807	14	.	.	.
cord-269011-230p8rsf	808	1	Spikes	spike	NNS
cord-269011-230p8rsf	808	2	seem	seem	VBP
cord-269011-230p8rsf	808	3	to	to	TO
cord-269011-230p8rsf	808	4	be	be	VB
cord-269011-230p8rsf	808	5	incorporated	incorporate	VBN
cord-269011-230p8rsf	808	6	in	in	IN
cord-269011-230p8rsf	808	7	variable	variable	JJ
cord-269011-230p8rsf	808	8	numbers	number	NNS
cord-269011-230p8rsf	808	9	depending	depend	VBG
cord-269011-230p8rsf	808	10	on	on	IN
cord-269011-230p8rsf	808	11	availability	availability	NN
cord-269011-230p8rsf	808	12	.	.	.
cord-269011-230p8rsf	809	1	They	-PRON-	PRP
cord-269011-230p8rsf	809	2	tolerate	tolerate	VBP
cord-269011-230p8rsf	809	3	severe	severe	JJ
cord-269011-230p8rsf	809	4	manipulation	manipulation	NN
cord-269011-230p8rsf	809	5	,	,	,
cord-269011-230p8rsf	809	6	both	both	DT
cord-269011-230p8rsf	809	7	of	of	IN
cord-269011-230p8rsf	809	8	their	-PRON-	PRP$
cord-269011-230p8rsf	809	9	ectodomain	ectodomain	NN
cord-269011-230p8rsf	809	10	and	and	CC
cord-269011-230p8rsf	809	11	of	of	IN
cord-269011-230p8rsf	809	12	their	-PRON-	PRP$
cord-269011-230p8rsf	809	13	endodomain	endodomain	NN
cord-269011-230p8rsf	809	14	.	.	.
cord-269011-230p8rsf	810	1	Thus	thus	RB
cord-269011-230p8rsf	810	2	,	,	,
cord-269011-230p8rsf	810	3	swapping	swapping	NN
cord-269011-230p8rsf	810	4	of	of	IN
cord-269011-230p8rsf	810	5	ectodomains	ectodomain	NNS
cord-269011-230p8rsf	810	6	between	between	IN
cord-269011-230p8rsf	810	7	unrelated	unrelated	JJ
cord-269011-230p8rsf	810	8	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	810	9	(	(	-LRB-
cord-269011-230p8rsf	810	10	i.e.	i.e.	FW
cord-269011-230p8rsf	810	11	,	,	,
cord-269011-230p8rsf	810	12	from	from	IN
cord-269011-230p8rsf	810	13	different	different	JJ
cord-269011-230p8rsf	810	14	groups	group	NNS
cord-269011-230p8rsf	810	15	)	)	-RRB-
cord-269011-230p8rsf	810	16	creates	create	VBZ
cord-269011-230p8rsf	810	17	viable	viable	JJ
cord-269011-230p8rsf	810	18	chimeric	chimeric	JJ
cord-269011-230p8rsf	810	19	viruses	virus	NNS
cord-269011-230p8rsf	810	20	whereas	whereas	IN
cord-269011-230p8rsf	810	21	a	a	DT
cord-269011-230p8rsf	810	22	foreign	foreign	JJ
cord-269011-230p8rsf	810	23	protein	protein	NN
cord-269011-230p8rsf	810	24	such	such	JJ
cord-269011-230p8rsf	810	25	as	as	IN
cord-269011-230p8rsf	810	26	GFP	GFP	NNP
cord-269011-230p8rsf	810	27	appended	append	VBN
cord-269011-230p8rsf	810	28	to	to	IN
cord-269011-230p8rsf	810	29	the	the	DT
cord-269011-230p8rsf	810	30	S	S	NNP
cord-269011-230p8rsf	810	31	protein	protein	NN
cord-269011-230p8rsf	810	32	endodomain	endodomain	NN
cord-269011-230p8rsf	810	33	is	be	VBZ
cord-269011-230p8rsf	810	34	accommodated	accommodate	VBN
cord-269011-230p8rsf	810	35	in	in	IN
cord-269011-230p8rsf	810	36	the	the	DT
cord-269011-230p8rsf	810	37	particle	particle	NN
cord-269011-230p8rsf	810	38	,	,	,
cord-269011-230p8rsf	810	39	although	although	IN
cord-269011-230p8rsf	810	40	reluctantly	reluctantly	RB
cord-269011-230p8rsf	810	41	.	.	.
cord-269011-230p8rsf	811	1	Some	some	DT
cord-269011-230p8rsf	811	2	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	811	3	have	have	VBP
cord-269011-230p8rsf	811	4	an	an	DT
cord-269011-230p8rsf	811	5	HE	HE	NNP
cord-269011-230p8rsf	811	6	protein	protein	NN
cord-269011-230p8rsf	811	7	but	but	CC
cord-269011-230p8rsf	811	8	continue	continue	VBP
cord-269011-230p8rsf	811	9	growing	grow	VBG
cord-269011-230p8rsf	811	10	well	well	RB
cord-269011-230p8rsf	811	11	if	if	IN
cord-269011-230p8rsf	811	12	for	for	IN
cord-269011-230p8rsf	811	13	any	any	DT
cord-269011-230p8rsf	811	14	reason	reason	NN
cord-269011-230p8rsf	811	15	the	the	DT
cord-269011-230p8rsf	811	16	gene	gene	NN
cord-269011-230p8rsf	811	17	is	be	VBZ
cord-269011-230p8rsf	811	18	not	not	RB
cord-269011-230p8rsf	811	19	(	(	-LRB-
cord-269011-230p8rsf	811	20	properly	properly	RB
cord-269011-230p8rsf	811	21	)	)	-RRB-
cord-269011-230p8rsf	811	22	expressed	express	VBN
cord-269011-230p8rsf	811	23	as	as	IN
cord-269011-230p8rsf	811	24	happens	happen	VBZ
cord-269011-230p8rsf	811	25	among	among	IN
cord-269011-230p8rsf	811	26	different	different	JJ
cord-269011-230p8rsf	811	27	MHVs	mhv	NNS
cord-269011-230p8rsf	811	28	.	.	.
cord-269011-230p8rsf	812	1	Consistently	consistently	RB
cord-269011-230p8rsf	812	2	,	,	,
cord-269011-230p8rsf	812	3	S	S	NNP
cord-269011-230p8rsf	812	4	and	and	CC
cord-269011-230p8rsf	812	5	HE	HE	NNP
cord-269011-230p8rsf	812	6	proteins	protein	NNS
cord-269011-230p8rsf	812	7	are	be	VBP
cord-269011-230p8rsf	812	8	incorporated	incorporate	VBN
cord-269011-230p8rsf	812	9	independent	independent	JJ
cord-269011-230p8rsf	812	10	from	from	IN
cord-269011-230p8rsf	812	11	each	each	DT
cord-269011-230p8rsf	812	12	other	other	JJ
cord-269011-230p8rsf	812	13	.	.	.
cord-269011-230p8rsf	813	1	Direct	direct	JJ
cord-269011-230p8rsf	813	2	interactions	interaction	NNS
cord-269011-230p8rsf	813	3	between	between	IN
cord-269011-230p8rsf	813	4	S	s	NN
cord-269011-230p8rsf	814	1	and	and	CC
cord-269011-230p8rsf	814	2	HE	he	PRP
cord-269011-230p8rsf	814	3	were	be	VBD
cord-269011-230p8rsf	814	4	not	not	RB
cord-269011-230p8rsf	814	5	observed	observe	VBN
cord-269011-230p8rsf	814	6	when	when	WRB
cord-269011-230p8rsf	814	7	the	the	DT
cord-269011-230p8rsf	814	8	proteins	protein	NNS
cord-269011-230p8rsf	814	9	were	be	VBD
cord-269011-230p8rsf	814	10	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	814	11	in	in	IN
cord-269011-230p8rsf	814	12	cells	cell	NNS
cord-269011-230p8rsf	814	13	(	(	-LRB-
cord-269011-230p8rsf	814	14	Nguyen	Nguyen	NNP
cord-269011-230p8rsf	814	15	and	and	CC
cord-269011-230p8rsf	814	16	Hogue	Hogue	NNP
cord-269011-230p8rsf	814	17	,	,	,
cord-269011-230p8rsf	814	18	1997	1997	CD
cord-269011-230p8rsf	814	19	)	)	-RRB-
cord-269011-230p8rsf	814	20	.	.	.
cord-269011-230p8rsf	815	1	This	this	DT
cord-269011-230p8rsf	815	2	result	result	NN
cord-269011-230p8rsf	815	3	is	be	VBZ
cord-269011-230p8rsf	815	4	consistent	consistent	JJ
cord-269011-230p8rsf	815	5	with	with	IN
cord-269011-230p8rsf	815	6	the	the	DT
cord-269011-230p8rsf	815	7	idea	idea	NN
cord-269011-230p8rsf	815	8	that	that	IN
cord-269011-230p8rsf	815	9	these	these	DT
cord-269011-230p8rsf	815	10	proteins	protein	NNS
cord-269011-230p8rsf	815	11	are	be	VBP
cord-269011-230p8rsf	815	12	separately	separately	RB
cord-269011-230p8rsf	815	13	drawn	draw	VBN
cord-269011-230p8rsf	815	14	into	into	IN
cord-269011-230p8rsf	815	15	the	the	DT
cord-269011-230p8rsf	815	16	M	M	NNP
cord-269011-230p8rsf	815	17	protein	protein	NN
cord-269011-230p8rsf	815	18	lattice	lattice	NN
cord-269011-230p8rsf	815	19	by	by	IN
cord-269011-230p8rsf	815	20	their	-PRON-	PRP$
cord-269011-230p8rsf	815	21	distinctive	distinctive	JJ
cord-269011-230p8rsf	815	22	interactions	interaction	NNS
cord-269011-230p8rsf	815	23	with	with	IN
cord-269011-230p8rsf	815	24	M	M	NNP
cord-269011-230p8rsf	815	25	molecules	molecule	NNS
cord-269011-230p8rsf	815	26	.	.	.
cord-269011-230p8rsf	816	1	It	-PRON-	PRP
cord-269011-230p8rsf	816	2	is	be	VBZ
cord-269011-230p8rsf	816	3	also	also	RB
cord-269011-230p8rsf	816	4	consistent	consistent	JJ
cord-269011-230p8rsf	816	5	with	with	IN
cord-269011-230p8rsf	816	6	the	the	DT
cord-269011-230p8rsf	816	7	concept	concept	NN
cord-269011-230p8rsf	816	8	that	that	IN
cord-269011-230p8rsf	816	9	these	these	DT
cord-269011-230p8rsf	816	10	proteins	protein	NNS
cord-269011-230p8rsf	816	11	assume	assume	VBP
cord-269011-230p8rsf	816	12	different	different	JJ
cord-269011-230p8rsf	816	13	positions	position	NNS
cord-269011-230p8rsf	816	14	within	within	IN
cord-269011-230p8rsf	816	15	this	this	DT
cord-269011-230p8rsf	816	16	lattice	lattice	NN
cord-269011-230p8rsf	816	17	,	,	,
cord-269011-230p8rsf	816	18	a	a	DT
cord-269011-230p8rsf	816	19	hypothesis	hypothesis	NN
cord-269011-230p8rsf	816	20	based	base	VBN
cord-269011-230p8rsf	816	21	on	on	IN
cord-269011-230p8rsf	816	22	the	the	DT
cord-269011-230p8rsf	816	23	presumed	presume	VBN
cord-269011-230p8rsf	816	24	different	different	JJ
cord-269011-230p8rsf	816	25	geometric	geometric	JJ
cord-269011-230p8rsf	816	26	requirements	requirement	NNS
cord-269011-230p8rsf	816	27	for	for	IN
cord-269011-230p8rsf	816	28	the	the	DT
cord-269011-230p8rsf	816	29	incorporation	incorporation	NN
cord-269011-230p8rsf	816	30	of	of	IN
cord-269011-230p8rsf	816	31	trimeric	trimeric	NNP
cord-269011-230p8rsf	816	32	and	and	CC
cord-269011-230p8rsf	816	33	di	di	NN
cord-269011-230p8rsf	816	34	-	-	,
cord-269011-230p8rsf	816	35	or	or	CC
cord-269011-230p8rsf	816	36	tetrameric	tetrameric	JJ
cord-269011-230p8rsf	816	37	S	S	NNP
cord-269011-230p8rsf	816	38	and	and	CC
cord-269011-230p8rsf	816	39	HE	HE	NNP
cord-269011-230p8rsf	816	40	complexes	complex	NNS
cord-269011-230p8rsf	816	41	,	,	,
cord-269011-230p8rsf	816	42	respectively	respectively	RB
cord-269011-230p8rsf	816	43	.	.	.
cord-269011-230p8rsf	817	1	How	how	WRB
cord-269011-230p8rsf	817	2	,	,	,
cord-269011-230p8rsf	817	3	in	in	IN
cord-269011-230p8rsf	817	4	the	the	DT
cord-269011-230p8rsf	817	5	face	face	NN
cord-269011-230p8rsf	817	6	of	of	IN
cord-269011-230p8rsf	817	7	this	this	DT
cord-269011-230p8rsf	817	8	enormous	enormous	JJ
cord-269011-230p8rsf	817	9	flexibility	flexibility	NN
cord-269011-230p8rsf	817	10	in	in	IN
cord-269011-230p8rsf	817	11	accommodating	accommodate	VBG
cord-269011-230p8rsf	817	12	all	all	PDT
cord-269011-230p8rsf	817	13	these	these	DT
cord-269011-230p8rsf	817	14	various	various	JJ
cord-269011-230p8rsf	817	15	numbers	number	NNS
cord-269011-230p8rsf	817	16	and	and	CC
cord-269011-230p8rsf	817	17	combinations	combination	NNS
cord-269011-230p8rsf	817	18	of	of	IN
cord-269011-230p8rsf	817	19	viral	viral	JJ
cord-269011-230p8rsf	817	20	components	component	NNS
cord-269011-230p8rsf	817	21	,	,	,
cord-269011-230p8rsf	817	22	do	do	VB
cord-269011-230p8rsf	817	23	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	817	24	manage	manage	VB
cord-269011-230p8rsf	817	25	to	to	TO
cord-269011-230p8rsf	817	26	maintain	maintain	VB
cord-269011-230p8rsf	817	27	specificity	specificity	NN
cord-269011-230p8rsf	817	28	?	?	.
cord-269011-230p8rsf	818	1	Host	host	NN
cord-269011-230p8rsf	818	2	proteins	protein	NNS
cord-269011-230p8rsf	818	3	have	have	VBP
cord-269011-230p8rsf	818	4	not	not	RB
cord-269011-230p8rsf	818	5	been	be	VBN
cord-269011-230p8rsf	818	6	noticed	notice	VBN
cord-269011-230p8rsf	818	7	to	to	TO
cord-269011-230p8rsf	818	8	occur	occur	VB
cord-269011-230p8rsf	818	9	in	in	IN
cord-269011-230p8rsf	818	10	virions	virion	NNS
cord-269011-230p8rsf	818	11	,	,	,
cord-269011-230p8rsf	818	12	although	although	IN
cord-269011-230p8rsf	818	13	this	this	DT
cord-269011-230p8rsf	818	14	may	may	MD
cord-269011-230p8rsf	818	15	simply	simply	RB
cord-269011-230p8rsf	818	16	not	not	RB
cord-269011-230p8rsf	818	17	have	have	VB
cord-269011-230p8rsf	818	18	been	be	VBN
cord-269011-230p8rsf	818	19	looked	look	VBN
cord-269011-230p8rsf	818	20	at	at	IN
cord-269011-230p8rsf	818	21	carefully	carefully	RB
cord-269011-230p8rsf	818	22	enough	enough	RB
cord-269011-230p8rsf	818	23	.	.	.
cord-269011-230p8rsf	819	1	By	by	IN
cord-269011-230p8rsf	819	2	probing	probe	VBG
cord-269011-230p8rsf	819	3	the	the	DT
cord-269011-230p8rsf	819	4	specificity	specificity	NN
cord-269011-230p8rsf	819	5	,	,	,
cord-269011-230p8rsf	819	6	using	use	VBG
cord-269011-230p8rsf	819	7	viral	viral	JJ
cord-269011-230p8rsf	819	8	and	and	CC
cord-269011-230p8rsf	819	9	nonviral	nonviral	JJ
cord-269011-230p8rsf	819	10	membrane	membrane	NN
cord-269011-230p8rsf	819	11	proteins	protein	NNS
cord-269011-230p8rsf	819	12	,	,	,
cord-269011-230p8rsf	819	13	it	-PRON-	PRP
cord-269011-230p8rsf	819	14	appeared	appear	VBD
cord-269011-230p8rsf	819	15	that	that	IN
cord-269011-230p8rsf	819	16	foreign	foreign	JJ
cord-269011-230p8rsf	819	17	proteins	protein	NNS
cord-269011-230p8rsf	819	18	are	be	VBP
cord-269011-230p8rsf	819	19	effectively	effectively	RB
cord-269011-230p8rsf	819	20	excluded	exclude	VBN
cord-269011-230p8rsf	819	21	from	from	IN
cord-269011-230p8rsf	819	22	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	819	23	particles	particle	NNS
cord-269011-230p8rsf	819	24	.	.	.
cord-269011-230p8rsf	820	1	However	however	RB
cord-269011-230p8rsf	820	2	,	,	,
cord-269011-230p8rsf	820	3	some	some	DT
cord-269011-230p8rsf	820	4	missorting	missorting	NN
cord-269011-230p8rsf	820	5	was	be	VBD
cord-269011-230p8rsf	820	6	found	find	VBN
cord-269011-230p8rsf	820	7	to	to	TO
cord-269011-230p8rsf	820	8	occur	occur	VB
cord-269011-230p8rsf	820	9	,	,	,
cord-269011-230p8rsf	820	10	consistent	consistent	JJ
cord-269011-230p8rsf	820	11	with	with	IN
cord-269011-230p8rsf	820	12	earlier	early	JJR
cord-269011-230p8rsf	820	13	observations	observation	NNS
cord-269011-230p8rsf	820	14	(	(	-LRB-
cord-269011-230p8rsf	820	15	Yoshikura	Yoshikura	NNP
cord-269011-230p8rsf	820	16	and	and	CC
cord-269011-230p8rsf	820	17	Taguchi	Taguchi	NNP
cord-269011-230p8rsf	820	18	,	,	,
cord-269011-230p8rsf	820	19	1978	1978	CD
cord-269011-230p8rsf	820	20	)	)	-RRB-
cord-269011-230p8rsf	820	21	.	.	.
cord-269011-230p8rsf	821	1	The	the	DT
cord-269011-230p8rsf	821	2	picture	picture	NN
cord-269011-230p8rsf	821	3	of	of	IN
cord-269011-230p8rsf	821	4	coronaviral	coronaviral	JJ
cord-269011-230p8rsf	821	5	envelope	envelope	NN
cord-269011-230p8rsf	821	6	formation	formation	NN
cord-269011-230p8rsf	821	7	is	be	VBZ
cord-269011-230p8rsf	821	8	one	one	NN
cord-269011-230p8rsf	821	9	that	that	WDT
cord-269011-230p8rsf	821	10	is	be	VBZ
cord-269011-230p8rsf	821	11	directed	direct	VBN
cord-269011-230p8rsf	821	12	entirely	entirely	RB
cord-269011-230p8rsf	821	13	by	by	IN
cord-269011-230p8rsf	821	14	lateral	lateral	JJ
cord-269011-230p8rsf	821	15	interactions	interaction	NNS
cord-269011-230p8rsf	821	16	between	between	IN
cord-269011-230p8rsf	821	17	the	the	DT
cord-269011-230p8rsf	821	18	envelope	envelope	NN
cord-269011-230p8rsf	821	19	proteins	protein	NNS
cord-269011-230p8rsf	821	20	.	.	.
cord-269011-230p8rsf	822	1	In	in	IN
cord-269011-230p8rsf	822	2	infected	infected	JJ
cord-269011-230p8rsf	822	3	cells	cell	NNS
cord-269011-230p8rsf	822	4	,	,	,
cord-269011-230p8rsf	822	5	membrane	membrane	NN
cord-269011-230p8rsf	822	6	proteins	protein	NNS
cord-269011-230p8rsf	822	7	-	-	:
cord-269011-230p8rsf	822	8	viral	viral	JJ
cord-269011-230p8rsf	822	9	and	and	CC
cord-269011-230p8rsf	822	10	cellular	cellular	JJ
cord-269011-230p8rsf	822	11	-	-	:
cord-269011-230p8rsf	822	12	are	be	VBP
cord-269011-230p8rsf	822	13	sampled	sample	VBN
cord-269011-230p8rsf	822	14	for	for	IN
cord-269011-230p8rsf	822	15	fit	fit	NN
cord-269011-230p8rsf	822	16	into	into	IN
cord-269011-230p8rsf	822	17	the	the	DT
cord-269011-230p8rsf	822	18	lattice	lattice	NN
cord-269011-230p8rsf	822	19	formed	form	VBN
cord-269011-230p8rsf	822	20	by	by	IN
cord-269011-230p8rsf	822	21	M	M	NNP
cord-269011-230p8rsf	822	22	molecules	molecule	NNS
cord-269011-230p8rsf	822	23	.	.	.
cord-269011-230p8rsf	823	1	The	the	DT
cord-269011-230p8rsf	823	2	specificity	specificity	NN
cord-269011-230p8rsf	823	3	of	of	IN
cord-269011-230p8rsf	823	4	the	the	DT
cord-269011-230p8rsf	823	5	molecular	molecular	JJ
cord-269011-230p8rsf	823	6	interactions	interaction	NNS
cord-269011-230p8rsf	823	7	acts	act	VBZ
cord-269011-230p8rsf	823	8	as	as	IN
cord-269011-230p8rsf	823	9	a	a	DT
cord-269011-230p8rsf	823	10	quality	quality	NN
cord-269011-230p8rsf	823	11	control	control	NN
cord-269011-230p8rsf	823	12	system	system	NN
cord-269011-230p8rsf	823	13	to	to	TO
cord-269011-230p8rsf	823	14	warrant	warrant	VB
cord-269011-230p8rsf	823	15	the	the	DT
cord-269011-230p8rsf	823	16	formation	formation	NN
cord-269011-230p8rsf	823	17	of	of	IN
cord-269011-230p8rsf	823	18	the	the	DT
cord-269011-230p8rsf	823	19	two	two	CD
cord-269011-230p8rsf	823	20	-	-	HYPH
cord-269011-230p8rsf	823	21	dimensional	dimensional	JJ
cord-269011-230p8rsf	823	22	assemblies	assembly	NNS
cord-269011-230p8rsf	823	23	that	that	WDT
cord-269011-230p8rsf	823	24	contain	contain	VBP
cord-269011-230p8rsf	823	25	the	the	DT
cord-269011-230p8rsf	823	26	full	full	JJ
cord-269011-230p8rsf	823	27	complement	complement	NN
cord-269011-230p8rsf	823	28	of	of	IN
cord-269011-230p8rsf	823	29	viral	viral	JJ
cord-269011-230p8rsf	823	30	membrane	membrane	NN
cord-269011-230p8rsf	823	31	proteins	protein	NNS
cord-269011-230p8rsf	823	32	but	but	CC
cord-269011-230p8rsf	823	33	from	from	IN
cord-269011-230p8rsf	823	34	which	which	WDT
cord-269011-230p8rsf	823	35	cellular	cellular	JJ
cord-269011-230p8rsf	823	36	proteins	protein	NNS
cord-269011-230p8rsf	823	37	are	be	VBP
cord-269011-230p8rsf	823	38	segregated	segregate	VBN
cord-269011-230p8rsf	823	39	.	.	.
cord-269011-230p8rsf	824	1	For	for	IN
cord-269011-230p8rsf	824	2	each	each	DT
cord-269011-230p8rsf	824	3	cellular	cellular	JJ
cord-269011-230p8rsf	824	4	protein	protein	NN
cord-269011-230p8rsf	824	5	the	the	DT
cord-269011-230p8rsf	824	6	efficiency	efficiency	NN
cord-269011-230p8rsf	824	7	of	of	IN
cord-269011-230p8rsf	824	8	this	this	DT
cord-269011-230p8rsf	824	9	exclusion	exclusion	NN
cord-269011-230p8rsf	824	10	process	process	NN
cord-269011-230p8rsf	824	11	is	be	VBZ
cord-269011-230p8rsf	824	12	determined	determine	VBN
cord-269011-230p8rsf	824	13	by	by	IN
cord-269011-230p8rsf	824	14	its	-PRON-	PRP$
cord-269011-230p8rsf	824	15	lack	lack	NN
cord-269011-230p8rsf	824	16	of	of	IN
cord-269011-230p8rsf	824	17	interaction	interaction	NN
cord-269011-230p8rsf	824	18	with	with	IN
cord-269011-230p8rsf	824	19	the	the	DT
cord-269011-230p8rsf	824	20	M	M	NNP
cord-269011-230p8rsf	824	21	protein	protein	NN
cord-269011-230p8rsf	824	22	,	,	,
cord-269011-230p8rsf	824	23	its	-PRON-	PRP$
cord-269011-230p8rsf	824	24	lack	lack	NN
cord-269011-230p8rsf	824	25	of	of	IN
cord-269011-230p8rsf	824	26	fit	fit	NN
cord-269011-230p8rsf	824	27	in	in	IN
cord-269011-230p8rsf	824	28	the	the	DT
cord-269011-230p8rsf	824	29	M	M	NNP
cord-269011-230p8rsf	824	30	protein	protein	NN
cord-269011-230p8rsf	824	31	framework	framework	NN
cord-269011-230p8rsf	824	32	,	,	,
cord-269011-230p8rsf	824	33	and	and	CC
cord-269011-230p8rsf	824	34	its	-PRON-	PRP$
cord-269011-230p8rsf	824	35	success	success	NN
cord-269011-230p8rsf	824	36	in	in	IN
cord-269011-230p8rsf	824	37	competing	compete	VBG
cord-269011-230p8rsf	824	38	with	with	IN
cord-269011-230p8rsf	824	39	the	the	DT
cord-269011-230p8rsf	824	40	S	S	NNP
cord-269011-230p8rsf	824	41	and	and	CC
cord-269011-230p8rsf	824	42	HE	HE	NNP
cord-269011-230p8rsf	824	43	oligomers	oligomer	VBZ
cord-269011-230p8rsf	824	44	for	for	IN
cord-269011-230p8rsf	824	45	the	the	DT
cord-269011-230p8rsf	824	46	(	(	-LRB-
cord-269011-230p8rsf	824	47	geometrically	geometrically	RB
cord-269011-230p8rsf	824	48	different	different	JJ
cord-269011-230p8rsf	824	49	)	)	-RRB-
cord-269011-230p8rsf	824	50	vacancies	vacancy	NNS
cord-269011-230p8rsf	824	51	within	within	IN
cord-269011-230p8rsf	824	52	this	this	DT
cord-269011-230p8rsf	824	53	framework	framework	NN
cord-269011-230p8rsf	824	54	.	.	.
cord-269011-230p8rsf	825	1	The	the	DT
cord-269011-230p8rsf	825	2	precise	precise	JJ
cord-269011-230p8rsf	825	3	location	location	NN
cord-269011-230p8rsf	825	4	of	of	IN
cord-269011-230p8rsf	825	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	825	6	budding	bud	VBG
cord-269011-230p8rsf	825	7	and	and	CC
cord-269011-230p8rsf	825	8	the	the	DT
cord-269011-230p8rsf	825	9	factors	factor	NNS
cord-269011-230p8rsf	825	10	that	that	WDT
cord-269011-230p8rsf	825	11	govern	govern	VBP
cord-269011-230p8rsf	825	12	it	-PRON-	PRP
cord-269011-230p8rsf	825	13	have	have	VBP
cord-269011-230p8rsf	825	14	not	not	RB
cord-269011-230p8rsf	825	15	been	be	VBN
cord-269011-230p8rsf	825	16	established	establish	VBN
cord-269011-230p8rsf	825	17	.	.	.
cord-269011-230p8rsf	826	1	Although	although	IN
cord-269011-230p8rsf	826	2	it	-PRON-	PRP
cord-269011-230p8rsf	826	3	is	be	VBZ
cord-269011-230p8rsf	826	4	clear	clear	JJ
cord-269011-230p8rsf	826	5	that	that	IN
cord-269011-230p8rsf	826	6	particle	particle	NN
cord-269011-230p8rsf	826	7	formation	formation	NN
cord-269011-230p8rsf	826	8	occurs	occur	VBZ
cord-269011-230p8rsf	826	9	at	at	IN
cord-269011-230p8rsf	826	10	membranes	membrane	NNS
cord-269011-230p8rsf	826	11	early	early	RB
cord-269011-230p8rsf	826	12	in	in	IN
cord-269011-230p8rsf	826	13	the	the	DT
cord-269011-230p8rsf	826	14	secretory	secretory	JJ
cord-269011-230p8rsf	826	15	pathway	pathway	NN
cord-269011-230p8rsf	826	16	,	,	,
cord-269011-230p8rsf	826	17	up	up	IN
cord-269011-230p8rsf	826	18	to	to	IN
cord-269011-230p8rsf	826	19	the	the	DT
cord-269011-230p8rsf	826	20	cis	cis	NNP
cord-269011-230p8rsf	826	21	-	-	HYPH
cord-269011-230p8rsf	826	22	Golgi	Golgi	NNP
cord-269011-230p8rsf	826	23	compartment	compartment	NN
cord-269011-230p8rsf	826	24	,	,	,
cord-269011-230p8rsf	826	25	the	the	DT
cord-269011-230p8rsf	826	26	precise	precise	JJ
cord-269011-230p8rsf	826	27	site	site	NN
cord-269011-230p8rsf	826	28	has	have	VBZ
cord-269011-230p8rsf	826	29	not	not	RB
cord-269011-230p8rsf	826	30	been	be	VBN
cord-269011-230p8rsf	826	31	identified	identify	VBN
cord-269011-230p8rsf	826	32	for	for	IN
cord-269011-230p8rsf	826	33	any	any	DT
cord-269011-230p8rsf	826	34	coronavirus	coronavirus	NN
cord-269011-230p8rsf	826	35	.	.	.
cord-269011-230p8rsf	827	1	Several	several	JJ
cord-269011-230p8rsf	827	2	considerations	consideration	NNS
cord-269011-230p8rsf	827	3	may	may	MD
cord-269011-230p8rsf	827	4	explain	explain	VB
cord-269011-230p8rsf	827	5	this	this	DT
cord-269011-230p8rsf	827	6	lack	lack	NN
cord-269011-230p8rsf	827	7	of	of	IN
cord-269011-230p8rsf	827	8	knowledge	knowledge	NN
cord-269011-230p8rsf	827	9	.	.	.
cord-269011-230p8rsf	828	1	One	one	CD
cord-269011-230p8rsf	828	2	is	be	VBZ
cord-269011-230p8rsf	828	3	that	that	IN
cord-269011-230p8rsf	828	4	these	these	DT
cord-269011-230p8rsf	828	5	early	early	JJ
cord-269011-230p8rsf	828	6	compartments	compartment	NNS
cord-269011-230p8rsf	828	7	are	be	VBP
cord-269011-230p8rsf	828	8	themselves	-PRON-	PRP
cord-269011-230p8rsf	828	9	rather	rather	RB
cord-269011-230p8rsf	828	10	complex	complex	JJ
cord-269011-230p8rsf	828	11	and	and	CC
cord-269011-230p8rsf	828	12	highly	highly	RB
cord-269011-230p8rsf	828	13	dynamic	dynamic	JJ
cord-269011-230p8rsf	828	14	and	and	CC
cord-269011-230p8rsf	828	15	have	have	VBP
cord-269011-230p8rsf	828	16	hence	hence	RB
cord-269011-230p8rsf	828	17	been	be	VBN
cord-269011-230p8rsf	828	18	difficult	difficult	JJ
cord-269011-230p8rsf	828	19	to	to	TO
cord-269011-230p8rsf	828	20	define	define	VB
cord-269011-230p8rsf	828	21	structurally	structurally	RB
cord-269011-230p8rsf	828	22	.	.	.
cord-269011-230p8rsf	829	1	Another	another	DT
cord-269011-230p8rsf	829	2	is	be	VBZ
cord-269011-230p8rsf	829	3	the	the	DT
cord-269011-230p8rsf	829	4	possible	possible	JJ
cord-269011-230p8rsf	829	5	alteration	alteration	NN
cord-269011-230p8rsf	829	6	of	of	IN
cord-269011-230p8rsf	829	7	the	the	DT
cord-269011-230p8rsf	829	8	structural	structural	JJ
cord-269011-230p8rsf	829	9	integrity	integrity	NN
cord-269011-230p8rsf	829	10	of	of	IN
cord-269011-230p8rsf	829	11	these	these	DT
cord-269011-230p8rsf	829	12	compartments	compartment	NNS
cord-269011-230p8rsf	829	13	by	by	IN
cord-269011-230p8rsf	829	14	infection	infection	NN
cord-269011-230p8rsf	829	15	;	;	:
cord-269011-230p8rsf	829	16	studies	study	NNS
cord-269011-230p8rsf	829	17	of	of	IN
cord-269011-230p8rsf	829	18	these	these	DT
cord-269011-230p8rsf	829	19	effects	effect	NNS
cord-269011-230p8rsf	829	20	have	have	VBP
cord-269011-230p8rsf	829	21	not	not	RB
cord-269011-230p8rsf	829	22	been	be	VBN
cord-269011-230p8rsf	829	23	described	describe	VBN
cord-269011-230p8rsf	829	24	.	.	.
cord-269011-230p8rsf	830	1	A	a	DT
cord-269011-230p8rsf	830	2	third	third	JJ
cord-269011-230p8rsf	830	3	complication	complication	NN
cord-269011-230p8rsf	830	4	may	may	MD
cord-269011-230p8rsf	830	5	be	be	VB
cord-269011-230p8rsf	830	6	that	that	IN
cord-269011-230p8rsf	830	7	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	830	8	do	do	VBP
cord-269011-230p8rsf	830	9	not	not	RB
cord-269011-230p8rsf	830	10	behave	behave	VB
cord-269011-230p8rsf	830	11	uniformly	uniformly	RB
cord-269011-230p8rsf	830	12	,	,	,
cord-269011-230p8rsf	830	13	different	different	JJ
cord-269011-230p8rsf	830	14	viruses	virus	NNS
cord-269011-230p8rsf	830	15	possibly	possibly	RB
cord-269011-230p8rsf	830	16	preferring	prefer	VBG
cord-269011-230p8rsf	830	17	different	different	JJ
cord-269011-230p8rsf	830	18	membranes	membrane	NNS
cord-269011-230p8rsf	830	19	for	for	IN
cord-269011-230p8rsf	830	20	budding	bud	VBG
cord-269011-230p8rsf	830	21	.	.	.
cord-269011-230p8rsf	831	1	In	in	IN
cord-269011-230p8rsf	831	2	this	this	DT
cord-269011-230p8rsf	831	3	respect	respect	NN
cord-269011-230p8rsf	831	4	it	-PRON-	PRP
cord-269011-230p8rsf	831	5	may	may	MD
cord-269011-230p8rsf	831	6	be	be	VB
cord-269011-230p8rsf	831	7	of	of	IN
cord-269011-230p8rsf	831	8	note	note	NN
cord-269011-230p8rsf	831	9	that	that	IN
cord-269011-230p8rsf	831	10	differences	difference	NNS
cord-269011-230p8rsf	831	11	have	have	VBP
cord-269011-230p8rsf	831	12	been	be	VBN
cord-269011-230p8rsf	831	13	observed	observe	VBN
cord-269011-230p8rsf	831	14	,	,	,
cord-269011-230p8rsf	831	15	for	for	IN
cord-269011-230p8rsf	831	16	instance	instance	NN
cord-269011-230p8rsf	831	17	,	,	,
cord-269011-230p8rsf	831	18	in	in	IN
cord-269011-230p8rsf	831	19	the	the	DT
cord-269011-230p8rsf	831	20	intrinsic	intrinsic	JJ
cord-269011-230p8rsf	831	21	localization	localization	NN
cord-269011-230p8rsf	831	22	of	of	IN
cord-269011-230p8rsf	831	23	the	the	DT
cord-269011-230p8rsf	831	24	M	M	NNP
cord-269011-230p8rsf	831	25	proteins	protein	NNS
cord-269011-230p8rsf	831	26	from	from	IN
cord-269011-230p8rsf	831	27	IBV	IBV	NNP
cord-269011-230p8rsf	831	28	and	and	CC
cord-269011-230p8rsf	831	29	MHV	MHV	NNP
cord-269011-230p8rsf	831	30	;	;	:
cord-269011-230p8rsf	831	31	they	-PRON-	PRP
cord-269011-230p8rsf	831	32	appeared	appear	VBD
cord-269011-230p8rsf	831	33	to	to	TO
cord-269011-230p8rsf	831	34	accumulate	accumulate	VB
cord-269011-230p8rsf	831	35	on	on	IN
cord-269011-230p8rsf	831	36	the	the	DT
cord-269011-230p8rsf	831	37	cis	cis	NNP
cord-269011-230p8rsf	831	38	and	and	CC
cord-269011-230p8rsf	831	39	trans	trans	NNP
cord-269011-230p8rsf	831	40	side	side	NN
cord-269011-230p8rsf	831	41	of	of	IN
cord-269011-230p8rsf	831	42	the	the	DT
cord-269011-230p8rsf	831	43	Golgi	Golgi	NNP
cord-269011-230p8rsf	831	44	apparatus	apparatus	NN
cord-269011-230p8rsf	831	45	,	,	,
cord-269011-230p8rsf	831	46	respectively	respectively	RB
cord-269011-230p8rsf	831	47	Machamer	Machamer	NNP
cord-269011-230p8rsf	831	48	et	et	NNP
cord-269011-230p8rsf	831	49	al	al	NNP
cord-269011-230p8rsf	831	50	.	.	NNP
cord-269011-230p8rsf	831	51	,	,	,
cord-269011-230p8rsf	831	52	1990	1990	CD
cord-269011-230p8rsf	831	53	)	)	-RRB-
cord-269011-230p8rsf	831	54	.	.	.
cord-269011-230p8rsf	832	1	It	-PRON-	PRP
cord-269011-230p8rsf	832	2	has	have	VBZ
cord-269011-230p8rsf	832	3	long	long	RB
cord-269011-230p8rsf	832	4	been	be	VBN
cord-269011-230p8rsf	832	5	assumed	assume	VBN
cord-269011-230p8rsf	832	6	that	that	IN
cord-269011-230p8rsf	832	7	the	the	DT
cord-269011-230p8rsf	832	8	M	M	NNP
cord-269011-230p8rsf	832	9	protein	protein	NN
cord-269011-230p8rsf	832	10	determines	determine	VBZ
cord-269011-230p8rsf	832	11	the	the	DT
cord-269011-230p8rsf	832	12	site	site	NN
cord-269011-230p8rsf	832	13	of	of	IN
cord-269011-230p8rsf	832	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	832	15	budding	bud	VBG
cord-269011-230p8rsf	832	16	.	.	.
cord-269011-230p8rsf	833	1	When	when	WRB
cord-269011-230p8rsf	833	2	,	,	,
cord-269011-230p8rsf	833	3	however	however	RB
cord-269011-230p8rsf	833	4	,	,	,
cord-269011-230p8rsf	833	5	this	this	DT
cord-269011-230p8rsf	833	6	protein	protein	NN
cord-269011-230p8rsf	833	7	appeared	appear	VBD
cord-269011-230p8rsf	833	8	to	to	TO
cord-269011-230p8rsf	833	9	localize	localize	VB
cord-269011-230p8rsf	833	10	beyond	beyond	IN
cord-269011-230p8rsf	833	11	this	this	DT
cord-269011-230p8rsf	833	12	site	site	NN
cord-269011-230p8rsf	833	13	,	,	,
cord-269011-230p8rsf	833	14	the	the	DT
cord-269011-230p8rsf	833	15	idea	idea	NN
cord-269011-230p8rsf	833	16	became	become	VBD
cord-269011-230p8rsf	833	17	attractive	attractive	JJ
cord-269011-230p8rsf	833	18	that	that	IN
cord-269011-230p8rsf	833	19	the	the	DT
cord-269011-230p8rsf	833	20	association	association	NN
cord-269011-230p8rsf	833	21	of	of	IN
cord-269011-230p8rsf	833	22	the	the	DT
cord-269011-230p8rsf	833	23	envelope	envelope	NN
cord-269011-230p8rsf	833	24	proteins	protein	NNS
cord-269011-230p8rsf	833	25	may	may	MD
cord-269011-230p8rsf	833	26	create	create	VB
cord-269011-230p8rsf	833	27	the	the	DT
cord-269011-230p8rsf	833	28	novel	novel	NN
cord-269011-230p8rsf	833	29	targeting	targeting	NN
cord-269011-230p8rsf	833	30	signals	signal	NNS
cord-269011-230p8rsf	833	31	that	that	WDT
cord-269011-230p8rsf	833	32	direct	direct	VBP
cord-269011-230p8rsf	833	33	these	these	DT
cord-269011-230p8rsf	833	34	multimeric	multimeric	JJ
cord-269011-230p8rsf	833	35	complexes	complex	NNS
cord-269011-230p8rsf	833	36	to	to	IN
cord-269011-230p8rsf	833	37	the	the	DT
cord-269011-230p8rsf	833	38	budding	bud	VBG
cord-269011-230p8rsf	833	39	site	site	NN
cord-269011-230p8rsf	833	40	.	.	.
cord-269011-230p8rsf	834	1	In	in	IN
cord-269011-230p8rsf	834	2	support	support	NN
cord-269011-230p8rsf	834	3	of	of	IN
cord-269011-230p8rsf	834	4	such	such	PDT
cord-269011-230p8rsf	834	5	a	a	DT
cord-269011-230p8rsf	834	6	notion	notion	NN
cord-269011-230p8rsf	834	7	is	be	VBZ
cord-269011-230p8rsf	834	8	the	the	DT
cord-269011-230p8rsf	834	9	fact	fact	NN
cord-269011-230p8rsf	834	10	that	that	IN
cord-269011-230p8rsf	834	11	the	the	DT
cord-269011-230p8rsf	834	12	S	S	NNP
cord-269011-230p8rsf	834	13	and	and	CC
cord-269011-230p8rsf	834	14	HE	HE	NNP
cord-269011-230p8rsf	834	15	proteins	protein	VBZ
cord-269011-230p8rsf	834	16	,	,	,
cord-269011-230p8rsf	834	17	when	when	WRB
cord-269011-230p8rsf	834	18	coexpressed	coexpresse	VBN
cord-269011-230p8rsf	834	19	with	with	IN
cord-269011-230p8rsf	834	20	the	the	DT
cord-269011-230p8rsf	834	21	M	M	NNP
cord-269011-230p8rsf	834	22	protein	protein	NN
cord-269011-230p8rsf	834	23	,	,	,
cord-269011-230p8rsf	834	24	are	be	VBP
cord-269011-230p8rsf	834	25	retained	retain	VBN
cord-269011-230p8rsf	834	26	in	in	IN
cord-269011-230p8rsf	834	27	the	the	DT
cord-269011-230p8rsf	834	28	Golgi	Golgi	NNP
cord-269011-230p8rsf	834	29	apparatus	apparatus	NN
cord-269011-230p8rsf	834	30	rather	rather	RB
cord-269011-230p8rsf	834	31	than	than	IN
cord-269011-230p8rsf	834	32	being	be	VBG
cord-269011-230p8rsf	834	33	transported	transport	VBN
cord-269011-230p8rsf	834	34	to	to	IN
cord-269011-230p8rsf	834	35	the	the	DT
cord-269011-230p8rsf	834	36	plasma	plasma	NN
cord-269011-230p8rsf	834	37	membrane	membrane	NN
cord-269011-230p8rsf	834	38	.	.	.
cord-269011-230p8rsf	835	1	The	the	DT
cord-269011-230p8rsf	835	2	critical	critical	JJ
cord-269011-230p8rsf	835	3	question	question	NN
cord-269011-230p8rsf	835	4	now	now	RB
cord-269011-230p8rsf	835	5	is	be	VBZ
cord-269011-230p8rsf	835	6	whether	whether	IN
cord-269011-230p8rsf	835	7	and	and	CC
cord-269011-230p8rsf	835	8	how	how	WRB
cord-269011-230p8rsf	835	9	the	the	DT
cord-269011-230p8rsf	835	10	E	e	NN
cord-269011-230p8rsf	835	11	protein	protein	NN
cord-269011-230p8rsf	835	12	affects	affect	VBZ
cord-269011-230p8rsf	835	13	the	the	DT
cord-269011-230p8rsf	835	14	localization	localization	NN
cord-269011-230p8rsf	835	15	of	of	IN
cord-269011-230p8rsf	835	16	the	the	DT
cord-269011-230p8rsf	835	17	M	M	NNP
cord-269011-230p8rsf	835	18	protein	protein	NN
cord-269011-230p8rsf	835	19	.	.	.
cord-269011-230p8rsf	836	1	As	as	IN
cord-269011-230p8rsf	836	2	the	the	DT
cord-269011-230p8rsf	836	3	E	e	NN
cord-269011-230p8rsf	836	4	protein	protein	NN
cord-269011-230p8rsf	836	5	by	by	IN
cord-269011-230p8rsf	836	6	itself	-PRON-	PRP
cord-269011-230p8rsf	836	7	does	do	VBZ
cord-269011-230p8rsf	836	8	not	not	RB
cord-269011-230p8rsf	836	9	seem	seem	VB
cord-269011-230p8rsf	836	10	to	to	TO
cord-269011-230p8rsf	836	11	localize	localize	VB
cord-269011-230p8rsf	836	12	to	to	IN
cord-269011-230p8rsf	836	13	the	the	DT
cord-269011-230p8rsf	836	14	virion	virion	NN
cord-269011-230p8rsf	836	15	budding	bud	VBG
cord-269011-230p8rsf	836	16	site	site	NN
cord-269011-230p8rsf	836	17	it	-PRON-	PRP
cord-269011-230p8rsf	836	18	will	will	MD
cord-269011-230p8rsf	836	19	be	be	VB
cord-269011-230p8rsf	836	20	of	of	IN
cord-269011-230p8rsf	836	21	great	great	JJ
cord-269011-230p8rsf	836	22	interest	interest	NN
cord-269011-230p8rsf	836	23	to	to	TO
cord-269011-230p8rsf	836	24	determine	determine	VB
cord-269011-230p8rsf	836	25	the	the	DT
cord-269011-230p8rsf	836	26	membranes	membrane	NNS
cord-269011-230p8rsf	836	27	at	at	IN
cord-269011-230p8rsf	836	28	which	which	WDT
cord-269011-230p8rsf	836	29	VLPs	vlp	NNS
cord-269011-230p8rsf	836	30	assemble	assemble	VBP
cord-269011-230p8rsf	836	31	.	.	.
cord-269011-230p8rsf	837	1	As	as	IN
cord-269011-230p8rsf	837	2	the	the	DT
cord-269011-230p8rsf	837	3	envelope	envelope	NN
cord-269011-230p8rsf	837	4	proteins	protein	NNS
cord-269011-230p8rsf	837	5	can	can	MD
cord-269011-230p8rsf	837	6	direct	direct	VB
cord-269011-230p8rsf	837	7	particle	particle	NN
cord-269011-230p8rsf	837	8	formation	formation	NN
cord-269011-230p8rsf	837	9	by	by	IN
cord-269011-230p8rsf	837	10	themselves	-PRON-	PRP
cord-269011-230p8rsf	837	11	,	,	,
cord-269011-230p8rsf	837	12	it	-PRON-	PRP
cord-269011-230p8rsf	837	13	may	may	MD
cord-269011-230p8rsf	837	14	seem	seem	VB
cord-269011-230p8rsf	837	15	that	that	IN
cord-269011-230p8rsf	837	16	the	the	DT
cord-269011-230p8rsf	837	17	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	837	18	is	be	VBZ
cord-269011-230p8rsf	837	19	not	not	RB
cord-269011-230p8rsf	837	20	leading	lead	VBG
cord-269011-230p8rsf	837	21	the	the	DT
cord-269011-230p8rsf	837	22	assembly	assembly	NN
cord-269011-230p8rsf	837	23	process	process	NN
cord-269011-230p8rsf	837	24	.	.	.
cord-269011-230p8rsf	838	1	Still	still	RB
cord-269011-230p8rsf	838	2	,	,	,
cord-269011-230p8rsf	838	3	besides	besides	IN
cord-269011-230p8rsf	838	4	giving	give	VBG
cord-269011-230p8rsf	838	5	rise	rise	NN
cord-269011-230p8rsf	838	6	to	to	IN
cord-269011-230p8rsf	838	7	virions	virion	NNS
cord-269011-230p8rsf	838	8	rather	rather	RB
cord-269011-230p8rsf	838	9	than	than	IN
cord-269011-230p8rsf	838	10	VLPs	vlp	NNS
cord-269011-230p8rsf	838	11	,	,	,
cord-269011-230p8rsf	838	12	its	-PRON-	PRP$
cord-269011-230p8rsf	838	13	involvement	involvement	NN
cord-269011-230p8rsf	838	14	in	in	IN
cord-269011-230p8rsf	838	15	assembly	assembly	NN
cord-269011-230p8rsf	838	16	might	may	MD
cord-269011-230p8rsf	838	17	have	have	VB
cord-269011-230p8rsf	838	18	important	important	JJ
cord-269011-230p8rsf	838	19	consequences	consequence	NNS
cord-269011-230p8rsf	838	20	.	.	.
cord-269011-230p8rsf	839	1	First	first	RB
cord-269011-230p8rsf	839	2	of	of	IN
cord-269011-230p8rsf	839	3	all	all	DT
cord-269011-230p8rsf	839	4	,	,	,
cord-269011-230p8rsf	839	5	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	839	6	may	may	MD
cord-269011-230p8rsf	839	7	enhance	enhance	VB
cord-269011-230p8rsf	839	8	the	the	DT
cord-269011-230p8rsf	839	9	efficiency	efficiency	NN
cord-269011-230p8rsf	839	10	of	of	IN
cord-269011-230p8rsf	839	11	the	the	DT
cord-269011-230p8rsf	839	12	budding	budding	JJ
cord-269011-230p8rsf	839	13	process	process	NN
cord-269011-230p8rsf	839	14	.	.	.
cord-269011-230p8rsf	840	1	The	the	DT
cord-269011-230p8rsf	840	2	physical	physical	JJ
cord-269011-230p8rsf	840	3	yields	yield	NNS
cord-269011-230p8rsf	840	4	of	of	IN
cord-269011-230p8rsf	840	5	VLPs	vlp	NNS
cord-269011-230p8rsf	840	6	obtained	obtain	VBN
cord-269011-230p8rsf	840	7	by	by	IN
cord-269011-230p8rsf	840	8	coexpression	coexpression	NN
cord-269011-230p8rsf	840	9	of	of	IN
cord-269011-230p8rsf	840	10	the	the	DT
cord-269011-230p8rsf	840	11	envelope	envelope	NN
cord-269011-230p8rsf	840	12	proteins	protein	NNS
cord-269011-230p8rsf	840	13	in	in	IN
cord-269011-230p8rsf	840	14	cells	cell	NNS
cord-269011-230p8rsf	840	15	are	be	VBP
cord-269011-230p8rsf	840	16	generally	generally	RB
cord-269011-230p8rsf	840	17	poor	poor	JJ
cord-269011-230p8rsf	840	18	.	.	.
cord-269011-230p8rsf	841	1	Although	although	IN
cord-269011-230p8rsf	841	2	there	there	EX
cord-269011-230p8rsf	841	3	may	may	MD
cord-269011-230p8rsf	841	4	be	be	VB
cord-269011-230p8rsf	841	5	many	many	JJ
cord-269011-230p8rsf	841	6	reasons	reason	NNS
cord-269011-230p8rsf	841	7	for	for	IN
cord-269011-230p8rsf	841	8	this	this	DT
cord-269011-230p8rsf	841	9	,	,	,
cord-269011-230p8rsf	841	10	in	in	IN
cord-269011-230p8rsf	841	11	infected	infected	JJ
cord-269011-230p8rsf	841	12	cells	cell	NNS
cord-269011-230p8rsf	841	13	the	the	DT
cord-269011-230p8rsf	841	14	availability	availability	NN
cord-269011-230p8rsf	841	15	of	of	IN
cord-269011-230p8rsf	841	16	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	841	17	is	be	VBZ
cord-269011-230p8rsf	841	18	likely	likely	JJ
cord-269011-230p8rsf	841	19	to	to	TO
cord-269011-230p8rsf	841	20	facilitate	facilitate	VB
cord-269011-230p8rsf	841	21	particle	particle	NN
cord-269011-230p8rsf	841	22	production	production	NN
cord-269011-230p8rsf	841	23	.	.	.
cord-269011-230p8rsf	842	1	Empty	empty	JJ
cord-269011-230p8rsf	842	2	particles	particle	NNS
cord-269011-230p8rsf	842	3	,	,	,
cord-269011-230p8rsf	842	4	considered	consider	VBN
cord-269011-230p8rsf	842	5	to	to	TO
cord-269011-230p8rsf	842	6	be	be	VB
cord-269011-230p8rsf	842	7	VLPs	vlp	NNS
cord-269011-230p8rsf	842	8	,	,	,
cord-269011-230p8rsf	842	9	have	have	VBP
cord-269011-230p8rsf	842	10	nevertheless	nevertheless	RB
cord-269011-230p8rsf	842	11	been	be	VBN
cord-269011-230p8rsf	842	12	observed	observe	VBN
cord-269011-230p8rsf	842	13	during	during	IN
cord-269011-230p8rsf	842	14	natural	natural	JJ
cord-269011-230p8rsf	842	15	infection	infection	NN
cord-269011-230p8rsf	842	16	(	(	-LRB-
cord-269011-230p8rsf	842	17	Afzelius	Afzelius	NNP
cord-269011-230p8rsf	842	18	,	,	,
cord-269011-230p8rsf	842	19	1994	1994	CD
cord-269011-230p8rsf	842	20	;	;	:
cord-269011-230p8rsf	842	21	Macnaughton	Macnaughton	NNP
cord-269011-230p8rsf	842	22	and	and	CC
cord-269011-230p8rsf	842	23	Davies	Davies	NNP
cord-269011-230p8rsf	842	24	,	,	,
cord-269011-230p8rsf	842	25	1980	1980	CD
cord-269011-230p8rsf	842	26	)	)	-RRB-
cord-269011-230p8rsf	842	27	.	.	.
cord-269011-230p8rsf	843	1	Their	-PRON-	PRP$
cord-269011-230p8rsf	843	2	formation	formation	NN
cord-269011-230p8rsf	843	3	might	may	MD
cord-269011-230p8rsf	843	4	simply	simply	RB
cord-269011-230p8rsf	843	5	serve	serve	VB
cord-269011-230p8rsf	843	6	as	as	IN
cord-269011-230p8rsf	843	7	a	a	DT
cord-269011-230p8rsf	843	8	means	means	NN
cord-269011-230p8rsf	843	9	to	to	TO
cord-269011-230p8rsf	843	10	dispose	dispose	VB
cord-269011-230p8rsf	843	11	of	of	IN
cord-269011-230p8rsf	843	12	excess	excess	JJ
cord-269011-230p8rsf	843	13	viral	viral	JJ
cord-269011-230p8rsf	843	14	membrane	membrane	NN
cord-269011-230p8rsf	843	15	proteins	protein	NNS
cord-269011-230p8rsf	843	16	from	from	IN
cord-269011-230p8rsf	843	17	infected	infected	JJ
cord-269011-230p8rsf	843	18	cells	cell	NNS
cord-269011-230p8rsf	843	19	if	if	IN
cord-269011-230p8rsf	843	20	required	require	VBN
cord-269011-230p8rsf	843	21	.	.	.
cord-269011-230p8rsf	844	1	Another	another	DT
cord-269011-230p8rsf	844	2	effect	effect	NN
cord-269011-230p8rsf	844	3	of	of	IN
cord-269011-230p8rsf	844	4	the	the	DT
cord-269011-230p8rsf	844	5	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	844	6	could	could	MD
cord-269011-230p8rsf	844	7	involve	involve	VB
cord-269011-230p8rsf	844	8	the	the	DT
cord-269011-230p8rsf	844	9	localization	localization	NN
cord-269011-230p8rsf	844	10	of	of	IN
cord-269011-230p8rsf	844	11	budding	bud	VBG
cord-269011-230p8rsf	844	12	.	.	.
cord-269011-230p8rsf	845	1	It	-PRON-	PRP
cord-269011-230p8rsf	845	2	is	be	VBZ
cord-269011-230p8rsf	845	3	conceivable	conceivable	JJ
cord-269011-230p8rsf	845	4	that	that	IN
cord-269011-230p8rsf	845	5	,	,	,
cord-269011-230p8rsf	845	6	unless	unless	IN
cord-269011-230p8rsf	845	7	a	a	DT
cord-269011-230p8rsf	845	8	defined	define	VBN
cord-269011-230p8rsf	845	9	budding	budding	NN
cord-269011-230p8rsf	845	10	station	station	NN
cord-269011-230p8rsf	845	11	is	be	VBZ
cord-269011-230p8rsf	845	12	created	create	VBN
cord-269011-230p8rsf	845	13	by	by	IN
cord-269011-230p8rsf	845	14	a	a	DT
cord-269011-230p8rsf	845	15	specific	specific	JJ
cord-269011-230p8rsf	845	16	interplay	interplay	NN
cord-269011-230p8rsf	845	17	between	between	IN
cord-269011-230p8rsf	845	18	viral	viral	JJ
cord-269011-230p8rsf	845	19	and	and	CC
cord-269011-230p8rsf	845	20	host	host	NN
cord-269011-230p8rsf	845	21	proteins	protein	NNS
cord-269011-230p8rsf	845	22	(	(	-LRB-
cord-269011-230p8rsf	845	23	for	for	IN
cord-269011-230p8rsf	845	24	which	which	WDT
cord-269011-230p8rsf	845	25	no	no	DT
cord-269011-230p8rsf	845	26	indications	indication	NNS
cord-269011-230p8rsf	845	27	yet	yet	RB
cord-269011-230p8rsf	845	28	exist	exist	VBP
cord-269011-230p8rsf	845	29	)	)	-RRB-
cord-269011-230p8rsf	845	30	,	,	,
cord-269011-230p8rsf	845	31	preassembled	preassembled	JJ
cord-269011-230p8rsf	845	32	nucleocapsids	nucleocapsids	NNP
cord-269011-230p8rsf	845	33	dock	dock	NN
cord-269011-230p8rsf	845	34	at	at	IN
cord-269011-230p8rsf	845	35	those	those	DT
cord-269011-230p8rsf	845	36	intracellular	intracellular	JJ
cord-269011-230p8rsf	845	37	membrane	membrane	NN
cord-269011-230p8rsf	845	38	sites	site	NNS
cord-269011-230p8rsf	845	39	where	where	WRB
cord-269011-230p8rsf	845	40	sufficiently	sufficiently	RB
cord-269011-230p8rsf	845	41	sized	sized	JJ
cord-269011-230p8rsf	845	42	patches	patch	NNS
cord-269011-230p8rsf	845	43	of	of	IN
cord-269011-230p8rsf	845	44	M	M	NNP
cord-269011-230p8rsf	845	45	protein	protein	NN
cord-269011-230p8rsf	845	46	-	-	HYPH
cord-269011-230p8rsf	845	47	based	base	VBN
cord-269011-230p8rsf	845	48	envelope	envelope	NN
cord-269011-230p8rsf	845	49	structure	structure	NN
cord-269011-230p8rsf	845	50	have	have	VBP
cord-269011-230p8rsf	845	51	accumulated	accumulate	VBN
cord-269011-230p8rsf	845	52	.	.	.
cord-269011-230p8rsf	846	1	Early	early	RB
cord-269011-230p8rsf	846	2	in	in	IN
cord-269011-230p8rsf	846	3	infection	infection	NN
cord-269011-230p8rsf	846	4	such	such	JJ
cord-269011-230p8rsf	846	5	patches	patch	NNS
cord-269011-230p8rsf	846	6	might	may	MD
cord-269011-230p8rsf	846	7	start	start	VB
cord-269011-230p8rsf	846	8	to	to	TO
cord-269011-230p8rsf	846	9	form	form	VB
cord-269011-230p8rsf	846	10	only	only	RB
cord-269011-230p8rsf	846	11	after	after	IN
cord-269011-230p8rsf	846	12	the	the	DT
cord-269011-230p8rsf	846	13	envelope	envelope	NN
cord-269011-230p8rsf	846	14	proteins	protein	NNS
cord-269011-230p8rsf	846	15	have	have	VBP
cord-269011-230p8rsf	846	16	left	leave	VBN
cord-269011-230p8rsf	846	17	the	the	DT
cord-269011-230p8rsf	846	18	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	846	19	reticulum	reticulum	NN
cord-269011-230p8rsf	846	20	and	and	CC
cord-269011-230p8rsf	846	21	become	become	VB
cord-269011-230p8rsf	846	22	concentrated	concentrated	JJ
cord-269011-230p8rsf	846	23	in	in	IN
cord-269011-230p8rsf	846	24	intermediate	intermediate	JJ
cord-269011-230p8rsf	846	25	membranes	membrane	NNS
cord-269011-230p8rsf	846	26	on	on	IN
cord-269011-230p8rsf	846	27	their	-PRON-	PRP$
cord-269011-230p8rsf	846	28	way	way	NN
cord-269011-230p8rsf	846	29	to	to	IN
cord-269011-230p8rsf	846	30	the	the	DT
cord-269011-230p8rsf	846	31	Golgi	Golgi	NNP
cord-269011-230p8rsf	846	32	complex	complex	NN
cord-269011-230p8rsf	846	33	.	.	.
cord-269011-230p8rsf	847	1	Later	later	RB
cord-269011-230p8rsf	847	2	,	,	,
cord-269011-230p8rsf	847	3	when	when	WRB
cord-269011-230p8rsf	847	4	viral	viral	JJ
cord-269011-230p8rsf	847	5	protein	protein	NN
cord-269011-230p8rsf	847	6	synthesis	synthesis	NN
cord-269011-230p8rsf	847	7	increases	increase	NNS
cord-269011-230p8rsf	847	8	,	,	,
cord-269011-230p8rsf	847	9	this	this	DT
cord-269011-230p8rsf	847	10	density	density	NN
cord-269011-230p8rsf	847	11	might	may	MD
cord-269011-230p8rsf	847	12	be	be	VB
cord-269011-230p8rsf	847	13	reached	reach	VBN
cord-269011-230p8rsf	847	14	earlier	early	RBR
cord-269011-230p8rsf	847	15	,	,	,
cord-269011-230p8rsf	847	16	perhaps	perhaps	RB
cord-269011-230p8rsf	847	17	explaining	explain	VBG
cord-269011-230p8rsf	847	18	the	the	DT
cord-269011-230p8rsf	847	19	observed	observed	JJ
cord-269011-230p8rsf	847	20	late	late	RB
cord-269011-230p8rsf	847	21	budding	bud	VBG
cord-269011-230p8rsf	847	22	in	in	IN
cord-269011-230p8rsf	847	23	the	the	DT
cord-269011-230p8rsf	847	24	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	847	25	reticulum	reticulum	NN
cord-269011-230p8rsf	847	26	(	(	-LRB-
cord-269011-230p8rsf	847	27	Goldsmith	Goldsmith	NNP
cord-269011-230p8rsf	847	28	et	et	FW
cord-269011-230p8rsf	847	29	al	al	NNP
cord-269011-230p8rsf	847	30	.	.	NNP
cord-269011-230p8rsf	847	31	,	,	,
cord-269011-230p8rsf	847	32	2004	2004	CD
cord-269011-230p8rsf	847	33	;	;	:
cord-269011-230p8rsf	847	34	Klumperman	Klumperman	NNP
cord-269011-230p8rsf	847	35	et	et	FW
cord-269011-230p8rsf	847	36	al	al	NNP
cord-269011-230p8rsf	847	37	.	.	NNP
cord-269011-230p8rsf	847	38	,	,	,
cord-269011-230p8rsf	847	39	1994	1994	CD
cord-269011-230p8rsf	847	40	;	;	:
cord-269011-230p8rsf	847	41	Tooze	Tooze	NNP
cord-269011-230p8rsf	847	42	et	et	NNP
cord-269011-230p8rsf	847	43	al	al	NNP
cord-269011-230p8rsf	847	44	.	.	NNP
cord-269011-230p8rsf	847	45	,	,	,
cord-269011-230p8rsf	847	46	1984	1984	CD
cord-269011-230p8rsf	847	47	)	)	-RRB-
cord-269011-230p8rsf	847	48	.	.	.
cord-269011-230p8rsf	848	1	It	-PRON-	PRP
cord-269011-230p8rsf	848	2	will	will	MD
cord-269011-230p8rsf	848	3	again	again	RB
cord-269011-230p8rsf	848	4	be	be	VB
cord-269011-230p8rsf	848	5	interesting	interesting	JJ
cord-269011-230p8rsf	848	6	to	to	TO
cord-269011-230p8rsf	848	7	learn	learn	VB
cord-269011-230p8rsf	848	8	where	where	WRB
cord-269011-230p8rsf	848	9	VLPs	vlp	NNS
cord-269011-230p8rsf	848	10	independently	independently	RB
cord-269011-230p8rsf	848	11	bud	bud	VBP
cord-269011-230p8rsf	848	12	and	and	CC
cord-269011-230p8rsf	848	13	how	how	WRB
cord-269011-230p8rsf	848	14	this	this	DT
cord-269011-230p8rsf	848	15	relates	relate	VBZ
cord-269011-230p8rsf	848	16	to	to	IN
cord-269011-230p8rsf	848	17	the	the	DT
cord-269011-230p8rsf	848	18	local	local	JJ
cord-269011-230p8rsf	848	19	density	density	NN
cord-269011-230p8rsf	848	20	of	of	IN
cord-269011-230p8rsf	848	21	the	the	DT
cord-269011-230p8rsf	848	22	envelope	envelope	NN
cord-269011-230p8rsf	848	23	proteins	protein	NNS
cord-269011-230p8rsf	848	24	because	because	IN
cord-269011-230p8rsf	848	25	this	this	DT
cord-269011-230p8rsf	848	26	information	information	NN
cord-269011-230p8rsf	848	27	will	will	MD
cord-269011-230p8rsf	848	28	shed	shed	VB
cord-269011-230p8rsf	848	29	light	light	NN
cord-269011-230p8rsf	848	30	on	on	IN
cord-269011-230p8rsf	848	31	the	the	DT
cord-269011-230p8rsf	848	32	role	role	NN
cord-269011-230p8rsf	848	33	of	of	IN
cord-269011-230p8rsf	848	34	the	the	DT
cord-269011-230p8rsf	848	35	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	848	36	in	in	IN
cord-269011-230p8rsf	848	37	the	the	DT
cord-269011-230p8rsf	848	38	localization	localization	NN
cord-269011-230p8rsf	848	39	of	of	IN
cord-269011-230p8rsf	848	40	virion	virion	NN
cord-269011-230p8rsf	848	41	assembly	assembly	NN
cord-269011-230p8rsf	848	42	.	.	.
cord-269011-230p8rsf	849	1	The	the	DT
cord-269011-230p8rsf	849	2	picture	picture	NN
cord-269011-230p8rsf	849	3	of	of	IN
cord-269011-230p8rsf	849	4	coronavirus	coronavirus	NN
cord-269011-230p8rsf	849	5	assembly	assembly	NN
cord-269011-230p8rsf	849	6	that	that	IN
cord-269011-230p8rsf	849	7	the	the	DT
cord-269011-230p8rsf	849	8	available	available	JJ
cord-269011-230p8rsf	849	9	literature	literature	NN
cord-269011-230p8rsf	849	10	allows	allow	VBZ
cord-269011-230p8rsf	849	11	us	-PRON-	PRP
cord-269011-230p8rsf	849	12	to	to	TO
cord-269011-230p8rsf	849	13	draw	draw	VB
cord-269011-230p8rsf	849	14	in	in	IN
cord-269011-230p8rsf	849	15	this	this	DT
cord-269011-230p8rsf	849	16	review	review	NN
cord-269011-230p8rsf	849	17	is	be	VBZ
cord-269011-230p8rsf	849	18	still	still	RB
cord-269011-230p8rsf	849	19	a	a	DT
cord-269011-230p8rsf	849	20	rough	rough	JJ
cord-269011-230p8rsf	849	21	draft	draft	NN
cord-269011-230p8rsf	849	22	.	.	.
cord-269011-230p8rsf	850	1	We	-PRON-	PRP
cord-269011-230p8rsf	850	2	know	know	VBP
cord-269011-230p8rsf	850	3	the	the	DT
cord-269011-230p8rsf	850	4	identity	identity	NN
cord-269011-230p8rsf	850	5	and	and	CC
cord-269011-230p8rsf	850	6	some	some	DT
cord-269011-230p8rsf	850	7	characteristics	characteristic	NNS
cord-269011-230p8rsf	850	8	of	of	IN
cord-269011-230p8rsf	850	9	the	the	DT
cord-269011-230p8rsf	850	10	key	key	JJ
cord-269011-230p8rsf	850	11	elements	element	NNS
cord-269011-230p8rsf	850	12	of	of	IN
cord-269011-230p8rsf	850	13	the	the	DT
cord-269011-230p8rsf	850	14	picture	picture	NN
cord-269011-230p8rsf	850	15	,	,	,
cord-269011-230p8rsf	850	16	we	-PRON-	PRP
cord-269011-230p8rsf	850	17	know	know	VBP
cord-269011-230p8rsf	850	18	the	the	DT
cord-269011-230p8rsf	850	19	relative	relative	JJ
cord-269011-230p8rsf	850	20	positions	position	NNS
cord-269011-230p8rsf	850	21	and	and	CC
cord-269011-230p8rsf	850	22	orientations	orientation	NNS
cord-269011-230p8rsf	850	23	of	of	IN
cord-269011-230p8rsf	850	24	most	most	JJS
cord-269011-230p8rsf	850	25	of	of	IN
cord-269011-230p8rsf	850	26	them	-PRON-	PRP
cord-269011-230p8rsf	850	27	,	,	,
cord-269011-230p8rsf	850	28	but	but	CC
cord-269011-230p8rsf	850	29	we	-PRON-	PRP
cord-269011-230p8rsf	850	30	are	be	VBP
cord-269011-230p8rsf	850	31	unable	unable	JJ
cord-269011-230p8rsf	850	32	to	to	TO
cord-269011-230p8rsf	850	33	fit	fit	VB
cord-269011-230p8rsf	850	34	them	-PRON-	PRP
cord-269011-230p8rsf	850	35	all	all	DT
cord-269011-230p8rsf	850	36	into	into	IN
cord-269011-230p8rsf	850	37	a	a	DT
cord-269011-230p8rsf	850	38	sensible	sensible	JJ
cord-269011-230p8rsf	850	39	composition	composition	NN
cord-269011-230p8rsf	850	40	.	.	.
cord-269011-230p8rsf	851	1	Although	although	IN
cord-269011-230p8rsf	851	2	this	this	DT
cord-269011-230p8rsf	851	3	may	may	MD
cord-269011-230p8rsf	851	4	seem	seem	VB
cord-269011-230p8rsf	851	5	like	like	IN
cord-269011-230p8rsf	851	6	a	a	DT
cord-269011-230p8rsf	851	7	discontented	discontented	JJ
cord-269011-230p8rsf	851	8	retrospective	retrospective	NN
cord-269011-230p8rsf	851	9	,	,	,
cord-269011-230p8rsf	851	10	it	-PRON-	PRP
cord-269011-230p8rsf	851	11	certainly	certainly	RB
cord-269011-230p8rsf	851	12	is	be	VBZ
cord-269011-230p8rsf	851	13	not	not	RB
cord-269011-230p8rsf	851	14	.	.	.
cord-269011-230p8rsf	852	1	In	in	IN
cord-269011-230p8rsf	852	2	the	the	DT
cord-269011-230p8rsf	852	3	25	25	CD
cord-269011-230p8rsf	852	4	years	year	NNS
cord-269011-230p8rsf	852	5	that	that	WDT
cord-269011-230p8rsf	852	6	the	the	DT
cord-269011-230p8rsf	852	7	senior	senior	JJ
cord-269011-230p8rsf	852	8	author	author	NN
cord-269011-230p8rsf	852	9	has	have	VBZ
cord-269011-230p8rsf	852	10	been	be	VBN
cord-269011-230p8rsf	852	11	in	in	IN
cord-269011-230p8rsf	852	12	coronavirology	coronavirology	NN
cord-269011-230p8rsf	852	13	research	research	NN
cord-269011-230p8rsf	852	14	,	,	,
cord-269011-230p8rsf	852	15	enormous	enormous	JJ
cord-269011-230p8rsf	852	16	progress	progress	NN
cord-269011-230p8rsf	852	17	has	have	VBZ
cord-269011-230p8rsf	852	18	been	be	VBN
cord-269011-230p8rsf	852	19	made	make	VBN
cord-269011-230p8rsf	852	20	in	in	IN
cord-269011-230p8rsf	852	21	practically	practically	RB
cord-269011-230p8rsf	852	22	all	all	PDT
cord-269011-230p8rsf	852	23	its	-PRON-	PRP$
cord-269011-230p8rsf	852	24	aspects	aspect	NNS
cord-269011-230p8rsf	852	25	including	include	VBG
cord-269011-230p8rsf	852	26	virion	virion	NN
cord-269011-230p8rsf	852	27	assembly	assembly	NN
cord-269011-230p8rsf	852	28	.	.	.
cord-269011-230p8rsf	853	1	However	however	RB
cord-269011-230p8rsf	853	2	,	,	,
cord-269011-230p8rsf	853	3	the	the	DT
cord-269011-230p8rsf	853	4	rewarding	rewarding	JJ
cord-269011-230p8rsf	853	5	act	act	NN
cord-269011-230p8rsf	853	6	of	of	IN
cord-269011-230p8rsf	853	7	compiling	compile	VBG
cord-269011-230p8rsf	853	8	and	and	CC
cord-269011-230p8rsf	853	9	ordering	order	VBG
cord-269011-230p8rsf	853	10	the	the	DT
cord-269011-230p8rsf	853	11	available	available	JJ
cord-269011-230p8rsf	853	12	information	information	NN
cord-269011-230p8rsf	853	13	and	and	CC
cord-269011-230p8rsf	853	14	trying	try	VBG
cord-269011-230p8rsf	853	15	to	to	TO
cord-269011-230p8rsf	853	16	abstract	abstract	VB
cord-269011-230p8rsf	853	17	from	from	IN
cord-269011-230p8rsf	853	18	it	-PRON-	PRP
cord-269011-230p8rsf	853	19	actual	actual	JJ
cord-269011-230p8rsf	853	20	knowledge	knowledge	NN
cord-269011-230p8rsf	853	21	was	be	VBD
cord-269011-230p8rsf	853	22	at	at	IN
cord-269011-230p8rsf	853	23	the	the	DT
cord-269011-230p8rsf	853	24	same	same	JJ
cord-269011-230p8rsf	853	25	time	time	NN
cord-269011-230p8rsf	853	26	a	a	DT
cord-269011-230p8rsf	853	27	sharp	sharp	JJ
cord-269011-230p8rsf	853	28	and	and	CC
cord-269011-230p8rsf	853	29	recurrent	recurrent	JJ
cord-269011-230p8rsf	853	30	confrontation	confrontation	NN
cord-269011-230p8rsf	853	31	with	with	IN
cord-269011-230p8rsf	853	32	the	the	DT
cord-269011-230p8rsf	853	33	unknown	unknown	NN
cord-269011-230p8rsf	853	34	.	.	.
cord-269011-230p8rsf	854	1	We	-PRON-	PRP
cord-269011-230p8rsf	854	2	want	want	VBP
cord-269011-230p8rsf	854	3	to	to	TO
cord-269011-230p8rsf	854	4	conclude	conclude	VB
cord-269011-230p8rsf	854	5	this	this	DT
cord-269011-230p8rsf	854	6	work	work	NN
cord-269011-230p8rsf	854	7	by	by	IN
cord-269011-230p8rsf	854	8	summarizing	summarize	VBG
cord-269011-230p8rsf	854	9	what	what	WP
cord-269011-230p8rsf	854	10	in	in	IN
cord-269011-230p8rsf	854	11	our	-PRON-	PRP$
cord-269011-230p8rsf	854	12	opinion	opinion	NN
cord-269011-230p8rsf	854	13	will	will	MD
cord-269011-230p8rsf	854	14	be	be	VB
cord-269011-230p8rsf	854	15	the	the	DT
cord-269011-230p8rsf	854	16	main	main	JJ
cord-269011-230p8rsf	854	17	issues	issue	NNS
cord-269011-230p8rsf	854	18	for	for	IN
cord-269011-230p8rsf	854	19	the	the	DT
cord-269011-230p8rsf	854	20	near	near	JJ
cord-269011-230p8rsf	854	21	future	future	NN
cord-269011-230p8rsf	854	22	.	.	.
cord-269011-230p8rsf	855	1	With	with	IN
cord-269011-230p8rsf	855	2	the	the	DT
cord-269011-230p8rsf	855	3	obstacle	obstacle	NN
cord-269011-230p8rsf	855	4	of	of	IN
cord-269011-230p8rsf	855	5	reverse	reverse	JJ
cord-269011-230p8rsf	855	6	genetics	genetics	NN
cord-269011-230p8rsf	855	7	technology	technology	NN
cord-269011-230p8rsf	855	8	solved	solve	VBD
cord-269011-230p8rsf	855	9	,	,	,
cord-269011-230p8rsf	855	10	"	"	``
cord-269011-230p8rsf	855	11	structure	structure	NN
cord-269011-230p8rsf	855	12	"	"	''
cord-269011-230p8rsf	855	13	will	will	MD
cord-269011-230p8rsf	855	14	be	be	VB
cord-269011-230p8rsf	855	15	the	the	DT
cord-269011-230p8rsf	855	16	dominating	dominating	JJ
cord-269011-230p8rsf	855	17	issue	issue	NN
cord-269011-230p8rsf	855	18	of	of	IN
cord-269011-230p8rsf	855	19	the	the	DT
cord-269011-230p8rsf	855	20	next	next	JJ
cord-269011-230p8rsf	855	21	decade	decade	NN
cord-269011-230p8rsf	855	22	.	.	.
cord-269011-230p8rsf	856	1	Biology	biology	NN
cord-269011-230p8rsf	856	2	has	have	VBZ
cord-269011-230p8rsf	856	3	taught	teach	VBN
cord-269011-230p8rsf	856	4	that	that	IN
cord-269011-230p8rsf	856	5	molecular	molecular	JJ
cord-269011-230p8rsf	856	6	insight	insight	NN
cord-269011-230p8rsf	856	7	into	into	IN
cord-269011-230p8rsf	856	8	processes	process	NNS
cord-269011-230p8rsf	856	9	will	will	MD
cord-269011-230p8rsf	856	10	eventually	eventually	RB
cord-269011-230p8rsf	856	11	depend	depend	VB
cord-269011-230p8rsf	856	12	critically	critically	RB
cord-269011-230p8rsf	856	13	on	on	IN
cord-269011-230p8rsf	856	14	detailed	detailed	JJ
cord-269011-230p8rsf	856	15	structural	structural	JJ
cord-269011-230p8rsf	856	16	information	information	NN
cord-269011-230p8rsf	856	17	.	.	.
cord-269011-230p8rsf	857	1	For	for	IN
cord-269011-230p8rsf	857	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	857	3	assembly	assembly	NN
cord-269011-230p8rsf	857	4	this	this	DT
cord-269011-230p8rsf	857	5	means	mean	VBZ
cord-269011-230p8rsf	857	6	data	datum	NNS
cord-269011-230p8rsf	857	7	on	on	IN
cord-269011-230p8rsf	857	8	the	the	DT
cord-269011-230p8rsf	857	9	individual	individual	JJ
cord-269011-230p8rsf	857	10	structural	structural	JJ
cord-269011-230p8rsf	857	11	components	component	NNS
cord-269011-230p8rsf	857	12	and	and	CC
cord-269011-230p8rsf	857	13	,	,	,
cord-269011-230p8rsf	857	14	particularly	particularly	RB
cord-269011-230p8rsf	857	15	,	,	,
cord-269011-230p8rsf	857	16	on	on	IN
cord-269011-230p8rsf	857	17	the	the	DT
cord-269011-230p8rsf	857	18	virion	virion	NN
cord-269011-230p8rsf	857	19	.	.	.
cord-269011-230p8rsf	858	1	With	with	IN
cord-269011-230p8rsf	858	2	respect	respect	NN
cord-269011-230p8rsf	858	3	to	to	IN
cord-269011-230p8rsf	858	4	the	the	DT
cord-269011-230p8rsf	858	5	former	former	JJ
cord-269011-230p8rsf	858	6	,	,	,
cord-269011-230p8rsf	858	7	this	this	DT
cord-269011-230p8rsf	858	8	will	will	MD
cord-269011-230p8rsf	858	9	be	be	VB
cord-269011-230p8rsf	858	10	most	most	RBS
cord-269011-230p8rsf	858	11	challenging	challenging	JJ
cord-269011-230p8rsf	858	12	for	for	IN
cord-269011-230p8rsf	858	13	the	the	DT
cord-269011-230p8rsf	858	14	membrane	membrane	NN
cord-269011-230p8rsf	858	15	proteins	protein	NNS
cord-269011-230p8rsf	858	16	,	,	,
cord-269011-230p8rsf	858	17	notably	notably	RB
cord-269011-230p8rsf	858	18	M	M	NNP
cord-269011-230p8rsf	858	19	and	and	CC
cord-269011-230p8rsf	858	20	E.	E.	NNP
cord-269011-230p8rsf	858	21	Virions	Virions	NNP
cord-269011-230p8rsf	858	22	,	,	,
cord-269011-230p8rsf	858	23	by	by	IN
cord-269011-230p8rsf	858	24	their	-PRON-	PRP$
cord-269011-230p8rsf	858	25	apparent	apparent	JJ
cord-269011-230p8rsf	858	26	elasticity	elasticity	NN
cord-269011-230p8rsf	858	27	,	,	,
cord-269011-230p8rsf	858	28	have	have	VBP
cord-269011-230p8rsf	858	29	eluded	elude	VBN
cord-269011-230p8rsf	858	30	structural	structural	JJ
cord-269011-230p8rsf	858	31	analysis	analysis	NN
cord-269011-230p8rsf	858	32	.	.	.
cord-269011-230p8rsf	859	1	Here	here	RB
cord-269011-230p8rsf	859	2	,	,	,
cord-269011-230p8rsf	859	3	despite	despite	IN
cord-269011-230p8rsf	859	4	the	the	DT
cord-269011-230p8rsf	859	5	still	still	RB
cord-269011-230p8rsf	859	6	limited	limited	JJ
cord-269011-230p8rsf	859	7	resolution	resolution	NN
cord-269011-230p8rsf	859	8	to	to	TO
cord-269011-230p8rsf	859	9	be	be	VB
cord-269011-230p8rsf	859	10	expected	expect	VBN
cord-269011-230p8rsf	859	11	,	,	,
cord-269011-230p8rsf	859	12	cryoelectron	cryoelectron	NNP
cord-269011-230p8rsf	859	13	microscopy	microscopy	NNP
cord-269011-230p8rsf	859	14	should	should	MD
cord-269011-230p8rsf	859	15	provide	provide	VB
cord-269011-230p8rsf	859	16	the	the	DT
cord-269011-230p8rsf	859	17	urgently	urgently	RB
cord-269011-230p8rsf	859	18	required	require	VBN
cord-269011-230p8rsf	859	19	insight	insight	NN
cord-269011-230p8rsf	859	20	into	into	IN
cord-269011-230p8rsf	859	21	the	the	DT
cord-269011-230p8rsf	859	22	structural	structural	JJ
cord-269011-230p8rsf	859	23	organization	organization	NN
cord-269011-230p8rsf	859	24	of	of	IN
cord-269011-230p8rsf	859	25	the	the	DT
cord-269011-230p8rsf	859	26	particle	particle	NN
cord-269011-230p8rsf	859	27	.	.	.
cord-269011-230p8rsf	860	1	Another	another	DT
cord-269011-230p8rsf	860	2	issue	issue	NN
cord-269011-230p8rsf	860	3	will	will	MD
cord-269011-230p8rsf	860	4	be	be	VB
cord-269011-230p8rsf	860	5	the	the	DT
cord-269011-230p8rsf	860	6	cell	cell	NN
cord-269011-230p8rsf	860	7	biology	biology	NN
cord-269011-230p8rsf	860	8	of	of	IN
cord-269011-230p8rsf	860	9	assembly	assembly	NN
cord-269011-230p8rsf	860	10	.	.	.
cord-269011-230p8rsf	861	1	This	this	DT
cord-269011-230p8rsf	861	2	actually	actually	RB
cord-269011-230p8rsf	861	3	refers	refer	VBZ
cord-269011-230p8rsf	861	4	to	to	IN
cord-269011-230p8rsf	861	5	a	a	DT
cord-269011-230p8rsf	861	6	number	number	NN
cord-269011-230p8rsf	861	7	of	of	IN
cord-269011-230p8rsf	861	8	poignant	poignant	JJ
cord-269011-230p8rsf	861	9	problems	problem	NNS
cord-269011-230p8rsf	861	10	at	at	IN
cord-269011-230p8rsf	861	11	every	every	DT
cord-269011-230p8rsf	861	12	stage	stage	NN
cord-269011-230p8rsf	861	13	of	of	IN
cord-269011-230p8rsf	861	14	the	the	DT
cord-269011-230p8rsf	861	15	process	process	NN
cord-269011-230p8rsf	861	16	.	.	.
cord-269011-230p8rsf	862	1	Starting	start	VBG
cord-269011-230p8rsf	862	2	with	with	IN
cord-269011-230p8rsf	862	3	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	862	4	formation	formation	NN
cord-269011-230p8rsf	862	5	we	-PRON-	PRP
cord-269011-230p8rsf	862	6	must	must	MD
cord-269011-230p8rsf	862	7	admit	admit	VB
cord-269011-230p8rsf	862	8	that	that	IN
cord-269011-230p8rsf	862	9	we	-PRON-	PRP
cord-269011-230p8rsf	862	10	know	know	VBP
cord-269011-230p8rsf	862	11	practically	practically	RB
cord-269011-230p8rsf	862	12	nothing	nothing	NN
cord-269011-230p8rsf	862	13	.	.	.
cord-269011-230p8rsf	863	1	By	by	IN
cord-269011-230p8rsf	863	2	which	which	WDT
cord-269011-230p8rsf	863	3	interactions	interaction	NNS
cord-269011-230p8rsf	863	4	and	and	CC
cord-269011-230p8rsf	863	5	where	where	WRB
cord-269011-230p8rsf	863	6	on	on	IN
cord-269011-230p8rsf	863	7	the	the	DT
cord-269011-230p8rsf	863	8	genome	genome	NN
cord-269011-230p8rsf	863	9	the	the	DT
cord-269011-230p8rsf	863	10	packaging	packaging	NN
cord-269011-230p8rsf	863	11	is	be	VBZ
cord-269011-230p8rsf	863	12	initiated	initiate	VBN
cord-269011-230p8rsf	863	13	,	,	,
cord-269011-230p8rsf	863	14	how	how	WRB
cord-269011-230p8rsf	863	15	the	the	DT
cord-269011-230p8rsf	863	16	wrapping	wrapping	NN
cord-269011-230p8rsf	863	17	of	of	IN
cord-269011-230p8rsf	863	18	the	the	DT
cord-269011-230p8rsf	863	19	RNA	RNA	NNP
cord-269011-230p8rsf	863	20	proceeds	proceed	NNS
cord-269011-230p8rsf	863	21	,	,	,
cord-269011-230p8rsf	863	22	how	how	WRB
cord-269011-230p8rsf	863	23	the	the	DT
cord-269011-230p8rsf	863	24	condensation	condensation	NN
cord-269011-230p8rsf	863	25	of	of	IN
cord-269011-230p8rsf	863	26	the	the	DT
cord-269011-230p8rsf	863	27	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	863	28	structure	structure	NN
cord-269011-230p8rsf	863	29	takes	take	VBZ
cord-269011-230p8rsf	863	30	place	place	NN
cord-269011-230p8rsf	863	31	,	,	,
cord-269011-230p8rsf	863	32	and	and	CC
cord-269011-230p8rsf	863	33	where	where	WRB
cord-269011-230p8rsf	863	34	in	in	IN
cord-269011-230p8rsf	863	35	the	the	DT
cord-269011-230p8rsf	863	36	cell	cell	NN
cord-269011-230p8rsf	863	37	these	these	DT
cord-269011-230p8rsf	863	38	activities	activity	NNS
cord-269011-230p8rsf	863	39	take	take	VBP
cord-269011-230p8rsf	863	40	place	place	NN
cord-269011-230p8rsf	863	41	are	be	VBP
cord-269011-230p8rsf	863	42	all	all	DT
cord-269011-230p8rsf	863	43	unresolved	unresolved	JJ
cord-269011-230p8rsf	863	44	questions	question	NNS
cord-269011-230p8rsf	863	45	.	.	.
cord-269011-230p8rsf	864	1	Although	although	IN
cord-269011-230p8rsf	864	2	we	-PRON-	PRP
cord-269011-230p8rsf	864	3	seem	seem	VBP
cord-269011-230p8rsf	864	4	to	to	TO
cord-269011-230p8rsf	864	5	know	know	VB
cord-269011-230p8rsf	864	6	more	more	JJR
cord-269011-230p8rsf	864	7	about	about	IN
cord-269011-230p8rsf	864	8	the	the	DT
cord-269011-230p8rsf	864	9	budding	budding	JJ
cord-269011-230p8rsf	864	10	process	process	NN
cord-269011-230p8rsf	864	11	,	,	,
cord-269011-230p8rsf	864	12	several	several	JJ
cord-269011-230p8rsf	864	13	fundamental	fundamental	JJ
cord-269011-230p8rsf	864	14	issues	issue	NNS
cord-269011-230p8rsf	864	15	are	be	VBP
cord-269011-230p8rsf	864	16	still	still	RB
cord-269011-230p8rsf	864	17	unresolved	unresolved	JJ
cord-269011-230p8rsf	864	18	.	.	.
cord-269011-230p8rsf	865	1	Obvious	obvious	JJ
cord-269011-230p8rsf	865	2	issues	issue	NNS
cord-269011-230p8rsf	865	3	are	be	VBP
cord-269011-230p8rsf	865	4	the	the	DT
cord-269011-230p8rsf	865	5	site	site	NN
cord-269011-230p8rsf	865	6	of	of	IN
cord-269011-230p8rsf	865	7	budding	bud	VBG
cord-269011-230p8rsf	865	8	and	and	CC
cord-269011-230p8rsf	865	9	the	the	DT
cord-269011-230p8rsf	865	10	determinants	determinant	NNS
cord-269011-230p8rsf	865	11	of	of	IN
cord-269011-230p8rsf	865	12	its	-PRON-	PRP$
cord-269011-230p8rsf	865	13	location	location	NN
cord-269011-230p8rsf	865	14	,	,	,
cord-269011-230p8rsf	865	15	and	and	CC
cord-269011-230p8rsf	865	16	the	the	DT
cord-269011-230p8rsf	865	17	inclusion	inclusion	NN
cord-269011-230p8rsf	865	18	of	of	IN
cord-269011-230p8rsf	865	19	the	the	DT
cord-269011-230p8rsf	865	20	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	865	21	into	into	IN
cord-269011-230p8rsf	865	22	the	the	DT
cord-269011-230p8rsf	865	23	budding	bud	VBG
cord-269011-230p8rsf	865	24	particle	particle	NN
cord-269011-230p8rsf	865	25	.	.	.
cord-269011-230p8rsf	866	1	An	an	DT
cord-269011-230p8rsf	866	2	intriguing	intriguing	JJ
cord-269011-230p8rsf	866	3	issue	issue	NN
cord-269011-230p8rsf	866	4	is	be	VBZ
cord-269011-230p8rsf	866	5	the	the	DT
cord-269011-230p8rsf	866	6	budding	budding	JJ
cord-269011-230p8rsf	866	7	mechanism	mechanism	NN
cord-269011-230p8rsf	866	8	itself	-PRON-	PRP
cord-269011-230p8rsf	866	9	:	:	:
cord-269011-230p8rsf	866	10	how	how	WRB
cord-269011-230p8rsf	866	11	is	be	VBZ
cord-269011-230p8rsf	866	12	membrane	membrane	NN
cord-269011-230p8rsf	866	13	curvature	curvature	NN
cord-269011-230p8rsf	866	14	generated	generate	VBN
cord-269011-230p8rsf	866	15	and	and	CC
cord-269011-230p8rsf	866	16	,	,	,
cord-269011-230p8rsf	866	17	particularly	particularly	RB
cord-269011-230p8rsf	866	18	,	,	,
cord-269011-230p8rsf	866	19	how	how	WRB
cord-269011-230p8rsf	866	20	is	be	VBZ
cord-269011-230p8rsf	866	21	the	the	DT
cord-269011-230p8rsf	866	22	directionality	directionality	NN
cord-269011-230p8rsf	866	23	determined	determine	VBN
cord-269011-230p8rsf	866	24	.	.	.
cord-269011-230p8rsf	867	1	Coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	867	2	,	,	,
cord-269011-230p8rsf	867	3	like	like	IN
cord-269011-230p8rsf	867	4	other	other	JJ
cord-269011-230p8rsf	867	5	intracellularly	intracellularly	RB
cord-269011-230p8rsf	867	6	budding	bud	VBG
cord-269011-230p8rsf	867	7	viruses	virus	NNS
cord-269011-230p8rsf	867	8	,	,	,
cord-269011-230p8rsf	867	9	direct	direct	VB
cord-269011-230p8rsf	867	10	their	-PRON-	PRP$
cord-269011-230p8rsf	867	11	particles	particle	NNS
cord-269011-230p8rsf	867	12	out	out	IN
cord-269011-230p8rsf	867	13	of	of	IN
cord-269011-230p8rsf	867	14	the	the	DT
cord-269011-230p8rsf	867	15	cytoplasm	cytoplasm	NN
cord-269011-230p8rsf	867	16	into	into	IN
cord-269011-230p8rsf	867	17	the	the	DT
cord-269011-230p8rsf	867	18	organelles	organelle	NNS
cord-269011-230p8rsf	867	19	,	,	,
cord-269011-230p8rsf	867	20	that	that	RB
cord-269011-230p8rsf	867	21	is	is	RB
cord-269011-230p8rsf	867	22	,	,	,
cord-269011-230p8rsf	867	23	opposite	opposite	JJ
cord-269011-230p8rsf	867	24	to	to	IN
cord-269011-230p8rsf	867	25	the	the	DT
cord-269011-230p8rsf	867	26	natural	natural	JJ
cord-269011-230p8rsf	867	27	direction	direction	NN
cord-269011-230p8rsf	867	28	of	of	IN
cord-269011-230p8rsf	867	29	cellular	cellular	JJ
cord-269011-230p8rsf	867	30	vesicle	vesicle	NN
cord-269011-230p8rsf	867	31	budding	bud	VBG
cord-269011-230p8rsf	867	32	.	.	.
cord-269011-230p8rsf	868	1	Once	once	RB
cord-269011-230p8rsf	868	2	again	again	RB
cord-269011-230p8rsf	868	3	,	,	,
cord-269011-230p8rsf	868	4	simply	simply	RB
cord-269011-230p8rsf	868	5	nothing	nothing	NN
cord-269011-230p8rsf	868	6	is	be	VBZ
cord-269011-230p8rsf	868	7	known	know	VBN
cord-269011-230p8rsf	868	8	about	about	IN
cord-269011-230p8rsf	868	9	the	the	DT
cord-269011-230p8rsf	868	10	governing	govern	VBG
cord-269011-230p8rsf	868	11	principles	principle	NNS
cord-269011-230p8rsf	868	12	.	.	.
cord-269011-230p8rsf	869	1	A	a	DT
cord-269011-230p8rsf	869	2	third	third	JJ
cord-269011-230p8rsf	869	3	field	field	NN
cord-269011-230p8rsf	869	4	of	of	IN
cord-269011-230p8rsf	869	5	research	research	NN
cord-269011-230p8rsf	869	6	that	that	WDT
cord-269011-230p8rsf	869	7	has	have	VBZ
cord-269011-230p8rsf	869	8	yet	yet	RB
cord-269011-230p8rsf	869	9	to	to	TO
cord-269011-230p8rsf	869	10	open	open	VB
cord-269011-230p8rsf	869	11	is	be	VBZ
cord-269011-230p8rsf	869	12	the	the	DT
cord-269011-230p8rsf	869	13	contribution	contribution	NN
cord-269011-230p8rsf	869	14	of	of	IN
cord-269011-230p8rsf	869	15	host	host	NN
cord-269011-230p8rsf	869	16	cellular	cellular	JJ
cord-269011-230p8rsf	869	17	factors	factor	NNS
cord-269011-230p8rsf	869	18	to	to	IN
cord-269011-230p8rsf	869	19	the	the	DT
cord-269011-230p8rsf	869	20	assembly	assembly	NN
cord-269011-230p8rsf	869	21	process	process	NN
cord-269011-230p8rsf	869	22	.	.	.
cord-269011-230p8rsf	870	1	Work	work	NN
cord-269011-230p8rsf	870	2	has	have	VBZ
cord-269011-230p8rsf	870	3	so	so	RB
cord-269011-230p8rsf	870	4	far	far	RB
cord-269011-230p8rsf	870	5	been	be	VBN
cord-269011-230p8rsf	870	6	concentrating	concentrate	VBG
cord-269011-230p8rsf	870	7	on	on	IN
cord-269011-230p8rsf	870	8	the	the	DT
cord-269011-230p8rsf	870	9	viral	viral	JJ
cord-269011-230p8rsf	870	10	components	component	NNS
cord-269011-230p8rsf	870	11	and	and	CC
cord-269011-230p8rsf	870	12	their	-PRON-	PRP$
cord-269011-230p8rsf	870	13	interplay	interplay	NN
cord-269011-230p8rsf	870	14	.	.	.
cord-269011-230p8rsf	871	1	Although	although	IN
cord-269011-230p8rsf	871	2	there	there	EX
cord-269011-230p8rsf	871	3	have	have	VBP
cord-269011-230p8rsf	871	4	been	be	VBN
cord-269011-230p8rsf	871	5	incidental	incidental	JJ
cord-269011-230p8rsf	871	6	indications	indication	NNS
cord-269011-230p8rsf	871	7	,	,	,
cord-269011-230p8rsf	871	8	studies	study	NNS
cord-269011-230p8rsf	871	9	on	on	IN
cord-269011-230p8rsf	871	10	the	the	DT
cord-269011-230p8rsf	871	11	specific	specific	JJ
cord-269011-230p8rsf	871	12	involvement	involvement	NN
cord-269011-230p8rsf	871	13	of	of	IN
cord-269011-230p8rsf	871	14	host	host	NN
cord-269011-230p8rsf	871	15	proteins	protein	NNS
cord-269011-230p8rsf	871	16	apparently	apparently	RB
cord-269011-230p8rsf	871	17	had	have	VBD
cord-269011-230p8rsf	871	18	to	to	TO
cord-269011-230p8rsf	871	19	await	await	VB
cord-269011-230p8rsf	871	20	the	the	DT
cord-269011-230p8rsf	871	21	development	development	NN
cord-269011-230p8rsf	871	22	of	of	IN
cord-269011-230p8rsf	871	23	appropriate	appropriate	JJ
cord-269011-230p8rsf	871	24	technologies	technology	NNS
cord-269011-230p8rsf	871	25	and	and	CC
cord-269011-230p8rsf	871	26	these	these	DT
cord-269011-230p8rsf	871	27	are	be	VBP
cord-269011-230p8rsf	871	28	now	now	RB
cord-269011-230p8rsf	871	29	becoming	become	VBG
cord-269011-230p8rsf	871	30	available	available	JJ
cord-269011-230p8rsf	871	31	.	.	.
cord-269011-230p8rsf	872	1	Although	although	IN
cord-269011-230p8rsf	872	2	the	the	DT
cord-269011-230p8rsf	872	3	serious	serious	JJ
cord-269011-230p8rsf	872	4	health	health	NN
cord-269011-230p8rsf	872	5	threat	threat	NN
cord-269011-230p8rsf	872	6	caused	cause	VBN
cord-269011-230p8rsf	872	7	by	by	IN
cord-269011-230p8rsf	872	8	the	the	DT
cord-269011-230p8rsf	872	9	2002	2002	CD
cord-269011-230p8rsf	872	10	-	-	SYM
cord-269011-230p8rsf	872	11	2003	2003	CD
cord-269011-230p8rsf	872	12	epidemic	epidemic	NN
cord-269011-230p8rsf	872	13	of	of	IN
cord-269011-230p8rsf	872	14	SARS	SARS	NNP
cord-269011-230p8rsf	872	15	apparently	apparently	RB
cord-269011-230p8rsf	872	16	has	have	VBZ
cord-269011-230p8rsf	872	17	waned	wane	VBN
cord-269011-230p8rsf	872	18	,	,	,
cord-269011-230p8rsf	872	19	the	the	DT
cord-269011-230p8rsf	872	20	coronavirological	coronavirological	JJ
cord-269011-230p8rsf	872	21	community	community	NN
cord-269011-230p8rsf	872	22	has	have	VBZ
cord-269011-230p8rsf	872	23	welcomed	welcome	VBN
cord-269011-230p8rsf	872	24	the	the	DT
cord-269011-230p8rsf	872	25	consequent	consequent	NN
cord-269011-230p8rsf	872	26	increased	increase	VBN
cord-269011-230p8rsf	872	27	interest	interest	NN
cord-269011-230p8rsf	872	28	in	in	IN
cord-269011-230p8rsf	872	29	this	this	DT
cord-269011-230p8rsf	872	30	family	family	NN
cord-269011-230p8rsf	872	31	of	of	IN
cord-269011-230p8rsf	872	32	viruses	virus	NNS
cord-269011-230p8rsf	872	33	.	.	.
cord-269011-230p8rsf	873	1	The	the	DT
cord-269011-230p8rsf	873	2	boost	boost	NN
cord-269011-230p8rsf	873	3	that	that	IN
cord-269011-230p8rsf	873	4	the	the	DT
cord-269011-230p8rsf	873	5	research	research	NN
cord-269011-230p8rsf	873	6	in	in	IN
cord-269011-230p8rsf	873	7	this	this	DT
cord-269011-230p8rsf	873	8	field	field	NN
cord-269011-230p8rsf	873	9	has	have	VBZ
cord-269011-230p8rsf	873	10	since	since	IN
cord-269011-230p8rsf	873	11	been	be	VBN
cord-269011-230p8rsf	873	12	experiencing	experience	VBG
cord-269011-230p8rsf	873	13	warrants	warrant	NNS
cord-269011-230p8rsf	873	14	an	an	DT
cord-269011-230p8rsf	873	15	exciting	exciting	JJ
cord-269011-230p8rsf	873	16	future	future	NN
cord-269011-230p8rsf	873	17	and	and	CC
cord-269011-230p8rsf	873	18	accelerated	accelerated	JJ
cord-269011-230p8rsf	873	19	progress	progress	NN
cord-269011-230p8rsf	873	20	with	with	IN
cord-269011-230p8rsf	873	21	the	the	DT
cord-269011-230p8rsf	873	22	elucidation	elucidation	NN
cord-269011-230p8rsf	873	23	of	of	IN
cord-269011-230p8rsf	873	24	the	the	DT
cord-269011-230p8rsf	873	25	fascinating	fascinating	JJ
cord-269011-230p8rsf	873	26	process	process	NN
cord-269011-230p8rsf	873	27	of	of	IN
cord-269011-230p8rsf	873	28	coronavirus	coronavirus	NN
cord-269011-230p8rsf	873	29	assembly	assembly	NN
cord-269011-230p8rsf	873	30	.	.	.
cord-269011-230p8rsf	874	1	Ultrastructure	Ultrastructure	NNP
cord-269011-230p8rsf	874	2	of	of	IN
cord-269011-230p8rsf	874	3	human	human	JJ
cord-269011-230p8rsf	874	4	nasal	nasal	NN
cord-269011-230p8rsf	874	5	epithelium	epithelium	NN
cord-269011-230p8rsf	874	6	during	during	IN
cord-269011-230p8rsf	874	7	an	an	DT
cord-269011-230p8rsf	874	8	episode	episode	NN
cord-269011-230p8rsf	874	9	of	of	IN
cord-269011-230p8rsf	874	10	coronavirus	coronavirus	NN
cord-269011-230p8rsf	874	11	infection	infection	NN
cord-269011-230p8rsf	874	12	Synthesis	synthesis	NN
cord-269011-230p8rsf	874	13	and	and	CC
cord-269011-230p8rsf	874	14	secretion	secretion	NN
cord-269011-230p8rsf	874	15	of	of	IN
cord-269011-230p8rsf	874	16	recombinant	recombinant	JJ
cord-269011-230p8rsf	874	17	tick	tick	NN
cord-269011-230p8rsf	874	18	-	-	HYPH
cord-269011-230p8rsf	874	19	borne	bear	VBN
cord-269011-230p8rsf	874	20	encephalitis	encephalitis	JJ
cord-269011-230p8rsf	874	21	virus	virus	NN
cord-269011-230p8rsf	874	22	protein	protein	NN
cord-269011-230p8rsf	874	23	E	e	NN
cord-269011-230p8rsf	874	24	in	in	IN
cord-269011-230p8rsf	874	25	soluble	soluble	JJ
cord-269011-230p8rsf	874	26	and	and	CC
cord-269011-230p8rsf	874	27	particulate	particulate	NN
cord-269011-230p8rsf	874	28	form	form	NN
cord-269011-230p8rsf	874	29	Induction	induction	NN
cord-269011-230p8rsf	874	30	of	of	IN
cord-269011-230p8rsf	874	31	apoptosis	apoptosis	NN
cord-269011-230p8rsf	874	32	in	in	IN
cord-269011-230p8rsf	874	33	murine	murine	JJ
cord-269011-230p8rsf	874	34	coronavirus	coronavirus	NN
cord-269011-230p8rsf	874	35	-	-	HYPH
cord-269011-230p8rsf	874	36	infected	infect	VBN
cord-269011-230p8rsf	874	37	cultured	cultured	JJ
cord-269011-230p8rsf	874	38	cells	cell	NNS
cord-269011-230p8rsf	874	39	and	and	CC
cord-269011-230p8rsf	874	40	demonstration	demonstration	NN
cord-269011-230p8rsf	874	41	of	of	IN
cord-269011-230p8rsf	874	42	E	e	NN
cord-269011-230p8rsf	874	43	protein	protein	NN
cord-269011-230p8rsf	874	44	as	as	IN
cord-269011-230p8rsf	874	45	an	an	DT
cord-269011-230p8rsf	874	46	apoptosis	apoptosis	NN
cord-269011-230p8rsf	874	47	inducer	inducer	NN
cord-269011-230p8rsf	874	48	Membrane	membrane	NN
cord-269011-230p8rsf	874	49	and	and	CC
cord-269011-230p8rsf	874	50	phospholipid	phospholipid	NN
cord-269011-230p8rsf	874	51	binding	bind	VBG
cord-269011-230p8rsf	874	52	by	by	IN
cord-269011-230p8rsf	874	53	murine	murine	JJ
cord-269011-230p8rsf	874	54	coronaviral	coronaviral	NNP
cord-269011-230p8rsf	874	55	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	874	56	N	N	NNP
cord-269011-230p8rsf	874	57	protein	protein	NN
cord-269011-230p8rsf	875	1	The	the	DT
cord-269011-230p8rsf	875	2	Golgi	Golgi	NNP
cord-269011-230p8rsf	875	3	sorting	sorting	NN
cord-269011-230p8rsf	875	4	domain	domain	NN
cord-269011-230p8rsf	875	5	of	of	IN
cord-269011-230p8rsf	875	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	875	7	E1	e1	NN
cord-269011-230p8rsf	875	8	protein	protein	NN
cord-269011-230p8rsf	875	9	Sequence	sequence	NN
cord-269011-230p8rsf	875	10	and	and	CC
cord-269011-230p8rsf	875	11	topology	topology	NN
cord-269011-230p8rsf	875	12	of	of	IN
cord-269011-230p8rsf	875	13	a	a	DT
cord-269011-230p8rsf	875	14	model	model	NN
cord-269011-230p8rsf	875	15	intracellular	intracellular	JJ
cord-269011-230p8rsf	875	16	membrane	membrane	NN
cord-269011-230p8rsf	875	17	protein	protein	NN
cord-269011-230p8rsf	875	18	,	,	,
cord-269011-230p8rsf	875	19	E1	E1	NNP
cord-269011-230p8rsf	875	20	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	875	21	,	,	,
cord-269011-230p8rsf	875	22	from	from	IN
cord-269011-230p8rsf	875	23	a	a	DT
cord-269011-230p8rsf	875	24	coronavirus	coronavirus	NN
cord-269011-230p8rsf	875	25	Lysosomal	Lysosomal	NNP
cord-269011-230p8rsf	875	26	sorting	sort	VBG
cord-269011-230p8rsf	875	27	mutants	mutant	NNS
cord-269011-230p8rsf	875	28	of	of	IN
cord-269011-230p8rsf	875	29	coronavirus	coronavirus	NN
cord-269011-230p8rsf	875	30	E1	e1	NN
cord-269011-230p8rsf	875	31	protein	protein	NN
cord-269011-230p8rsf	875	32	,	,	,
cord-269011-230p8rsf	875	33	a	a	DT
cord-269011-230p8rsf	875	34	Golgi	Golgi	NNP
cord-269011-230p8rsf	875	35	membrane	membrane	NN
cord-269011-230p8rsf	875	36	protein	protein	NN
cord-269011-230p8rsf	875	37	Amino	amino	NN
cord-269011-230p8rsf	875	38	acids	acid	NNS
cord-269011-230p8rsf	875	39	270	270	CD
cord-269011-230p8rsf	875	40	to	to	IN
cord-269011-230p8rsf	875	41	510	510	CD
cord-269011-230p8rsf	875	42	of	of	IN
cord-269011-230p8rsf	875	43	the	the	DT
cord-269011-230p8rsf	875	44	severe	severe	JJ
cord-269011-230p8rsf	875	45	acute	acute	JJ
cord-269011-230p8rsf	875	46	respiratory	respiratory	JJ
cord-269011-230p8rsf	875	47	syndrome	syndrome	NN
cord-269011-230p8rsf	875	48	coronavirus	coronavirus	NN
cord-269011-230p8rsf	875	49	spike	spike	NN
cord-269011-230p8rsf	875	50	protein	protein	NN
cord-269011-230p8rsf	875	51	are	be	VBP
cord-269011-230p8rsf	875	52	required	require	VBN
cord-269011-230p8rsf	875	53	for	for	IN
cord-269011-230p8rsf	875	54	interaction	interaction	NN
cord-269011-230p8rsf	875	55	with	with	IN
cord-269011-230p8rsf	875	56	receptor	receptor	NN
cord-269011-230p8rsf	875	57	Interactions	Interactions	NNPS
cord-269011-230p8rsf	875	58	between	between	IN
cord-269011-230p8rsf	875	59	coronavirus	coronavirus	NN
cord-269011-230p8rsf	875	60	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	875	61	protein	protein	NN
cord-269011-230p8rsf	875	62	and	and	CC
cord-269011-230p8rsf	875	63	viral	viral	JJ
cord-269011-230p8rsf	875	64	RNAs	rna	NNS
cord-269011-230p8rsf	875	65	:	:	:
cord-269011-230p8rsf	875	66	Implications	implication	NNS
cord-269011-230p8rsf	875	67	for	for	IN
cord-269011-230p8rsf	875	68	viral	viral	JJ
cord-269011-230p8rsf	875	69	transcription	transcription	NN
cord-269011-230p8rsf	876	1	Interferon	interferon	NN
cord-269011-230p8rsf	876	2	a	a	DT
cord-269011-230p8rsf	876	3	inducing	induce	VBG
cord-269011-230p8rsf	876	4	property	property	NN
cord-269011-230p8rsf	876	5	of	of	IN
cord-269011-230p8rsf	876	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	876	7	particles	particle	NNS
cord-269011-230p8rsf	876	8	and	and	CC
cord-269011-230p8rsf	876	9	pseudoparticles	pseudoparticle	NNS
cord-269011-230p8rsf	876	10	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	876	11	pseudoparticles	pseudoparticle	NNS
cord-269011-230p8rsf	876	12	formed	form	VBN
cord-269011-230p8rsf	876	13	with	with	IN
cord-269011-230p8rsf	876	14	recombinant	recombinant	JJ
cord-269011-230p8rsf	876	15	M	M	NNP
cord-269011-230p8rsf	876	16	and	and	CC
cord-269011-230p8rsf	876	17	E	e	NN
cord-269011-230p8rsf	876	18	proteins	protein	NNS
cord-269011-230p8rsf	876	19	induce	induce	VBP
cord-269011-230p8rsf	876	20	a	a	DT
cord-269011-230p8rsf	876	21	interferon	interferon	NN
cord-269011-230p8rsf	876	22	synthesis	synthesis	NN
cord-269011-230p8rsf	876	23	by	by	IN
cord-269011-230p8rsf	876	24	leukocytes	leukocyte	NNS
cord-269011-230p8rsf	876	25	Morphogenesis	Morphogenesis	NNP
cord-269011-230p8rsf	876	26	of	of	IN
cord-269011-230p8rsf	876	27	avian	avian	JJ
cord-269011-230p8rsf	876	28	infectious	infectious	JJ
cord-269011-230p8rsf	876	29	bronchitis	bronchitis	NN
cord-269011-230p8rsf	876	30	virus	virus	NN
cord-269011-230p8rsf	876	31	and	and	CC
cord-269011-230p8rsf	876	32	a	a	DT
cord-269011-230p8rsf	876	33	related	relate	VBN
cord-269011-230p8rsf	876	34	human	human	JJ
cord-269011-230p8rsf	876	35	virus	virus	NN
cord-269011-230p8rsf	876	36	(	(	-LRB-
cord-269011-230p8rsf	876	37	strain	strain	NN
cord-269011-230p8rsf	876	38	229E	229e	CD
cord-269011-230p8rsf	876	39	)	)	-RRB-
cord-269011-230p8rsf	877	1	Severe	severe	JJ
cord-269011-230p8rsf	877	2	acute	acute	JJ
cord-269011-230p8rsf	877	3	respiratory	respiratory	JJ
cord-269011-230p8rsf	877	4	syndrome	syndrome	NN
cord-269011-230p8rsf	877	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	877	6	spike	spike	NN
cord-269011-230p8rsf	877	7	protein	protein	NN
cord-269011-230p8rsf	877	8	expressed	express	VBN
cord-269011-230p8rsf	877	9	by	by	IN
cord-269011-230p8rsf	877	10	attenuated	attenuated	JJ
cord-269011-230p8rsf	877	11	vaccinia	vaccinia	NN
cord-269011-230p8rsf	877	12	virus	virus	NN
cord-269011-230p8rsf	877	13	protectively	protectively	RB
cord-269011-230p8rsf	877	14	immunizes	immunize	VBZ
cord-269011-230p8rsf	877	15	mice	mouse	NNS
cord-269011-230p8rsf	877	16	Identification	identification	NN
cord-269011-230p8rsf	877	17	of	of	IN
cord-269011-230p8rsf	877	18	a	a	DT
cord-269011-230p8rsf	877	19	receptor	receptor	NN
cord-269011-230p8rsf	877	20	-	-	HYPH
cord-269011-230p8rsf	877	21	binding	bind	VBG
cord-269011-230p8rsf	877	22	domain	domain	NN
cord-269011-230p8rsf	877	23	of	of	IN
cord-269011-230p8rsf	877	24	the	the	DT
cord-269011-230p8rsf	877	25	spike	spike	NN
cord-269011-230p8rsf	877	26	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	877	27	of	of	IN
cord-269011-230p8rsf	877	28	human	human	JJ
cord-269011-230p8rsf	877	29	coronavirus	coronavirus	NN
cord-269011-230p8rsf	877	30	HCoV-229E	HCoV-229E	NNP
cord-269011-230p8rsf	877	31	A	A	NNP
cord-269011-230p8rsf	877	32	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	877	33	mRNA	mRNA	NNP
cord-269011-230p8rsf	877	34	transcript	transcript	NN
cord-269011-230p8rsf	877	35	of	of	IN
cord-269011-230p8rsf	877	36	the	the	DT
cord-269011-230p8rsf	877	37	coronavirus	coronavirus	NN
cord-269011-230p8rsf	877	38	mouse	mouse	NN
cord-269011-230p8rsf	877	39	hepatitis	hepatitis	NN
cord-269011-230p8rsf	877	40	virus	virus	NN
cord-269011-230p8rsf	877	41	strain	strain	VBP
cord-269011-230p8rsf	877	42	A59	A59	NNP
cord-269011-230p8rsf	877	43	defective	defective	JJ
cord-269011-230p8rsf	877	44	interfering	interfere	VBG
cord-269011-230p8rsf	877	45	(	(	-LRB-
cord-269011-230p8rsf	877	46	DI	DI	NNP
cord-269011-230p8rsf	877	47	)	)	-RRB-
cord-269011-230p8rsf	877	48	RNA	RNA	NNP
cord-269011-230p8rsf	877	49	is	be	VBZ
cord-269011-230p8rsf	877	50	packaged	package	VBN
cord-269011-230p8rsf	877	51	when	when	WRB
cord-269011-230p8rsf	877	52	it	-PRON-	PRP
cord-269011-230p8rsf	877	53	contains	contain	VBZ
cord-269011-230p8rsf	877	54	the	the	DT
cord-269011-230p8rsf	877	55	DI	DI	NNP
cord-269011-230p8rsf	877	56	packaging	packaging	NN
cord-269011-230p8rsf	877	57	signal	signal	NN
cord-269011-230p8rsf	877	58	Mutational	Mutational	NNP
cord-269011-230p8rsf	877	59	analysis	analysis	NN
cord-269011-230p8rsf	877	60	of	of	IN
cord-269011-230p8rsf	877	61	the	the	DT
cord-269011-230p8rsf	877	62	murine	murine	JJ
cord-269011-230p8rsf	877	63	coronavirus	coronavirus	NN
cord-269011-230p8rsf	877	64	spike	spike	NN
cord-269011-230p8rsf	877	65	protein	protein	NN
cord-269011-230p8rsf	877	66	:	:	:
cord-269011-230p8rsf	877	67	Effect	effect	NN
cord-269011-230p8rsf	877	68	on	on	IN
cord-269011-230p8rsf	877	69	cell	cell	NN
cord-269011-230p8rsf	877	70	-	-	HYPH
cord-269011-230p8rsf	877	71	to	to	IN
cord-269011-230p8rsf	877	72	-	-	HYPH
cord-269011-230p8rsf	877	73	cell	cell	NN
cord-269011-230p8rsf	877	74	fusion	fusion	NN
cord-269011-230p8rsf	878	1	The	the	DT
cord-269011-230p8rsf	878	2	production	production	NN
cord-269011-230p8rsf	878	3	of	of	IN
cord-269011-230p8rsf	878	4	recombinant	recombinant	JJ
cord-269011-230p8rsf	878	5	infectious	infectious	JJ
cord-269011-230p8rsf	878	6	DI	di	NN
cord-269011-230p8rsf	878	7	-	-	HYPH
cord-269011-230p8rsf	878	8	particles	particle	NNS
cord-269011-230p8rsf	878	9	of	of	IN
cord-269011-230p8rsf	878	10	a	a	DT
cord-269011-230p8rsf	878	11	murine	murine	JJ
cord-269011-230p8rsf	878	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	878	13	in	in	IN
cord-269011-230p8rsf	878	14	the	the	DT
cord-269011-230p8rsf	878	15	absence	absence	NN
cord-269011-230p8rsf	878	16	of	of	IN
cord-269011-230p8rsf	878	17	helper	helper	NN
cord-269011-230p8rsf	878	18	virus	virus	NN
cord-269011-230p8rsf	879	1	The	the	DT
cord-269011-230p8rsf	879	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	879	3	spike	spike	NN
cord-269011-230p8rsf	879	4	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	879	5	,	,	,
cord-269011-230p8rsf	879	6	extended	extend	VBN
cord-269011-230p8rsf	879	7	carboxy	carboxy	NN
cord-269011-230p8rsf	879	8	terminally	terminally	RB
cord-269011-230p8rsf	879	9	with	with	IN
cord-269011-230p8rsf	879	10	the	the	DT
cord-269011-230p8rsf	879	11	green	green	JJ
cord-269011-230p8rsf	879	12	fluorescent	fluorescent	NN
cord-269011-230p8rsf	879	13	protein	protein	NN
cord-269011-230p8rsf	879	14	,	,	,
cord-269011-230p8rsf	879	15	is	be	VBZ
cord-269011-230p8rsf	879	16	assembly	assembly	NN
cord-269011-230p8rsf	879	17	competent	competent	JJ
cord-269011-230p8rsf	879	18	Severe	severe	JJ
cord-269011-230p8rsf	879	19	acute	acute	JJ
cord-269011-230p8rsf	879	20	respiratory	respiratory	JJ
cord-269011-230p8rsf	879	21	syndrome	syndrome	NN
cord-269011-230p8rsf	879	22	coronavirus	coronavirus	NN
cord-269011-230p8rsf	879	23	(	(	-LRB-
cord-269011-230p8rsf	880	1	SARS	SARS	NNP
cord-269011-230p8rsf	880	2	-	-	HYPH
cord-269011-230p8rsf	880	3	CoV	CoV	NNP
cord-269011-230p8rsf	880	4	)	)	-RRB-
cord-269011-230p8rsf	880	5	infection	infection	NN
cord-269011-230p8rsf	880	6	inhibition	inhibition	NN
cord-269011-230p8rsf	880	7	using	use	VBG
cord-269011-230p8rsf	880	8	spike	spike	NN
cord-269011-230p8rsf	880	9	protein	protein	NN
cord-269011-230p8rsf	880	10	heptad	heptad	NN
cord-269011-230p8rsf	880	11	repeat	repeat	NN
cord-269011-230p8rsf	880	12	-	-	HYPH
cord-269011-230p8rsf	880	13	derived	derive	VBN
cord-269011-230p8rsf	880	14	peptides	peptide	NNS
cord-269011-230p8rsf	881	1	The	the	DT
cord-269011-230p8rsf	881	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	881	3	spike	spike	NN
cord-269011-230p8rsf	881	4	protein	protein	NN
cord-269011-230p8rsf	881	5	is	be	VBZ
cord-269011-230p8rsf	881	6	a	a	DT
cord-269011-230p8rsf	881	7	class	class	NN
cord-269011-230p8rsf	881	8	I	-PRON-	PRP
cord-269011-230p8rsf	881	9	virus	virus	NN
cord-269011-230p8rsf	881	10	fusion	fusion	NN
cord-269011-230p8rsf	881	11	protein	protein	NN
cord-269011-230p8rsf	881	12	:	:	:
cord-269011-230p8rsf	882	1	Structural	structural	JJ
cord-269011-230p8rsf	882	2	and	and	CC
cord-269011-230p8rsf	882	3	functional	functional	JJ
cord-269011-230p8rsf	882	4	characterization	characterization	NN
cord-269011-230p8rsf	882	5	of	of	IN
cord-269011-230p8rsf	882	6	the	the	DT
cord-269011-230p8rsf	882	7	fusion	fusion	NN
cord-269011-230p8rsf	882	8	core	core	NN
cord-269011-230p8rsf	882	9	complex	complex	JJ
cord-269011-230p8rsf	882	10	Four	four	CD
cord-269011-230p8rsf	882	11	proteins	protein	NNS
cord-269011-230p8rsf	882	12	processed	process	VBN
cord-269011-230p8rsf	882	13	from	from	IN
cord-269011-230p8rsf	882	14	the	the	DT
cord-269011-230p8rsf	882	15	replicase	replicase	NNP
cord-269011-230p8rsf	882	16	gene	gene	NNP
cord-269011-230p8rsf	882	17	polyprotein	polyprotein	NNP
cord-269011-230p8rsf	882	18	of	of	IN
cord-269011-230p8rsf	882	19	mouse	mouse	NNP
cord-269011-230p8rsf	882	20	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	882	21	virus	virus	NN
cord-269011-230p8rsf	882	22	colocalize	colocalize	NN
cord-269011-230p8rsf	882	23	in	in	IN
cord-269011-230p8rsf	882	24	the	the	DT
cord-269011-230p8rsf	882	25	cell	cell	NN
cord-269011-230p8rsf	882	26	periphery	periphery	NN
cord-269011-230p8rsf	882	27	and	and	CC
cord-269011-230p8rsf	882	28	adjacent	adjacent	JJ
cord-269011-230p8rsf	882	29	to	to	IN
cord-269011-230p8rsf	882	30	sites	site	NNS
cord-269011-230p8rsf	882	31	of	of	IN
cord-269011-230p8rsf	882	32	virion	virion	NN
cord-269011-230p8rsf	882	33	assembly	assembly	NN
cord-269011-230p8rsf	882	34	Mouse	Mouse	NNP
cord-269011-230p8rsf	882	35	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	882	36	virus	virus	NN
cord-269011-230p8rsf	882	37	replicase	replicase	NNP
cord-269011-230p8rsf	882	38	protein	protein	NN
cord-269011-230p8rsf	882	39	complexes	complex	NNS
cord-269011-230p8rsf	882	40	are	be	VBP
cord-269011-230p8rsf	882	41	translocated	translocate	VBN
cord-269011-230p8rsf	882	42	to	to	IN
cord-269011-230p8rsf	882	43	sites	site	NNS
cord-269011-230p8rsf	882	44	of	of	IN
cord-269011-230p8rsf	882	45	M	M	NNP
cord-269011-230p8rsf	882	46	protein	protein	NN
cord-269011-230p8rsf	882	47	accumulation	accumulation	NN
cord-269011-230p8rsf	882	48	in	in	IN
cord-269011-230p8rsf	882	49	the	the	DT
cord-269011-230p8rsf	882	50	ERGIC	ERGIC	NNP
cord-269011-230p8rsf	882	51	at	at	IN
cord-269011-230p8rsf	882	52	late	late	JJ
cord-269011-230p8rsf	882	53	times	time	NNS
cord-269011-230p8rsf	882	54	of	of	IN
cord-269011-230p8rsf	882	55	infection	infection	NN
cord-269011-230p8rsf	882	56	Host	Host	NNP
cord-269011-230p8rsf	882	57	cell	cell	NN
cord-269011-230p8rsf	882	58	nuclear	nuclear	JJ
cord-269011-230p8rsf	882	59	function	function	NN
cord-269011-230p8rsf	882	60	and	and	CC
cord-269011-230p8rsf	882	61	murine	murine	JJ
cord-269011-230p8rsf	882	62	hepatitis	hepatitis	NN
cord-269011-230p8rsf	882	63	virus	virus	NN
cord-269011-230p8rsf	882	64	replication	replication	NN
cord-269011-230p8rsf	882	65	Human	human	JJ
cord-269011-230p8rsf	882	66	coronavirus	coronavirus	NN
cord-269011-230p8rsf	882	67	229E	229e	CD
cord-269011-230p8rsf	882	68	:	:	:
cord-269011-230p8rsf	883	1	Receptor	receptor	NN
cord-269011-230p8rsf	883	2	binding	bind	VBG
cord-269011-230p8rsf	883	3	domain	domain	NN
cord-269011-230p8rsf	883	4	and	and	CC
cord-269011-230p8rsf	883	5	neutralization	neutralization	NN
cord-269011-230p8rsf	883	6	by	by	IN
cord-269011-230p8rsf	883	7	soluble	soluble	JJ
cord-269011-230p8rsf	883	8	receptor	receptor	NN
cord-269011-230p8rsf	883	9	at	at	IN
cord-269011-230p8rsf	883	10	37	37	CD
cord-269011-230p8rsf	883	11	C	c	NN
cord-269011-230p8rsf	884	1	The	the	DT
cord-269011-230p8rsf	884	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	884	3	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	884	4	esterase	esterase	NN
cord-269011-230p8rsf	884	5	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	884	6	Replication	replication	NN
cord-269011-230p8rsf	884	7	of	of	IN
cord-269011-230p8rsf	884	8	an	an	DT
cord-269011-230p8rsf	884	9	enteric	enteric	JJ
cord-269011-230p8rsf	884	10	bovine	bovine	JJ
cord-269011-230p8rsf	884	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	884	12	in	in	IN
cord-269011-230p8rsf	884	13	intestinal	intestinal	JJ
cord-269011-230p8rsf	884	14	organ	organ	NN
cord-269011-230p8rsf	884	15	cultures	culture	NNS
cord-269011-230p8rsf	885	1	The	the	DT
cord-269011-230p8rsf	885	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	885	3	nonstructural	nonstructural	JJ
cord-269011-230p8rsf	885	4	proteins	protein	NNS
cord-269011-230p8rsf	885	5	Preliminary	preliminary	JJ
cord-269011-230p8rsf	885	6	studies	study	NNS
cord-269011-230p8rsf	885	7	on	on	IN
cord-269011-230p8rsf	885	8	the	the	DT
cord-269011-230p8rsf	885	9	isolation	isolation	NN
cord-269011-230p8rsf	885	10	of	of	IN
cord-269011-230p8rsf	885	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	885	12	229E	229e	CD
cord-269011-230p8rsf	885	13	nucleocapsids	nucleocapsid	NNS
cord-269011-230p8rsf	886	1	Further	further	JJ
cord-269011-230p8rsf	886	2	studies	study	NNS
cord-269011-230p8rsf	886	3	on	on	IN
cord-269011-230p8rsf	886	4	human	human	JJ
cord-269011-230p8rsf	886	5	enteric	enteric	JJ
cord-269011-230p8rsf	886	6	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	886	7	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	886	8	IBV	IBV	NNP
cord-269011-230p8rsf	886	9	:	:	:
cord-269011-230p8rsf	887	1	Further	further	JJ
cord-269011-230p8rsf	887	2	evidence	evidence	NN
cord-269011-230p8rsf	887	3	that	that	IN
cord-269011-230p8rsf	887	4	the	the	DT
cord-269011-230p8rsf	887	5	surface	surface	NN
cord-269011-230p8rsf	887	6	projections	projection	NNS
cord-269011-230p8rsf	887	7	are	be	VBP
cord-269011-230p8rsf	887	8	associated	associate	VBN
cord-269011-230p8rsf	887	9	with	with	IN
cord-269011-230p8rsf	887	10	two	two	CD
cord-269011-230p8rsf	887	11	glycopolypeptides	glycopolypeptide	NNS
cord-269011-230p8rsf	887	12	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	887	13	IBV	IBV	NNP
cord-269011-230p8rsf	887	14	:	:	:
cord-269011-230p8rsf	888	1	Structural	structural	JJ
cord-269011-230p8rsf	888	2	characterization	characterization	NN
cord-269011-230p8rsf	888	3	of	of	IN
cord-269011-230p8rsf	888	4	the	the	DT
cord-269011-230p8rsf	888	5	spike	spike	NN
cord-269011-230p8rsf	888	6	protein	protein	NN
cord-269011-230p8rsf	889	1	The	the	DT
cord-269011-230p8rsf	889	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	889	3	surface	surface	NN
cord-269011-230p8rsf	889	4	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	889	5	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	889	6	IBV	IBV	NNP
cord-269011-230p8rsf	889	7	glycopolypeptides	glycopolypeptide	NNS
cord-269011-230p8rsf	890	1	:	:	:
cord-269011-230p8rsf	890	2	Locational	locational	JJ
cord-269011-230p8rsf	890	3	studies	study	NNS
cord-269011-230p8rsf	890	4	using	use	VBG
cord-269011-230p8rsf	890	5	proteases	protease	NNS
cord-269011-230p8rsf	890	6	and	and	CC
cord-269011-230p8rsf	890	7	saponin	saponin	NN
cord-269011-230p8rsf	890	8	,	,	,
cord-269011-230p8rsf	890	9	a	a	DT
cord-269011-230p8rsf	890	10	membrane	membrane	NN
cord-269011-230p8rsf	890	11	permeablizer	permeablizer	NN
cord-269011-230p8rsf	890	12	Heptad	Heptad	NNP
cord-269011-230p8rsf	890	13	repeat	repeat	NN
cord-269011-230p8rsf	890	14	sequences	sequence	NNS
cord-269011-230p8rsf	890	15	are	be	VBP
cord-269011-230p8rsf	890	16	located	locate	VBN
cord-269011-230p8rsf	890	17	adjacent	adjacent	JJ
cord-269011-230p8rsf	890	18	to	to	IN
cord-269011-230p8rsf	890	19	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	890	20	regions	region	NNS
cord-269011-230p8rsf	890	21	in	in	IN
cord-269011-230p8rsf	890	22	several	several	JJ
cord-269011-230p8rsf	890	23	types	type	NNS
cord-269011-230p8rsf	890	24	of	of	IN
cord-269011-230p8rsf	890	25	virus	virus	NN
cord-269011-230p8rsf	890	26	fusion	fusion	NN
cord-269011-230p8rsf	890	27	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	890	28	Effects	effect	NNS
cord-269011-230p8rsf	890	29	of	of	IN
cord-269011-230p8rsf	890	30	amino	amino	NN
cord-269011-230p8rsf	890	31	acid	acid	NN
cord-269011-230p8rsf	890	32	insertions	insertion	NNS
cord-269011-230p8rsf	890	33	in	in	IN
cord-269011-230p8rsf	890	34	the	the	DT
cord-269011-230p8rsf	890	35	cysteinerich	cysteinerich	NN
cord-269011-230p8rsf	890	36	domain	domain	NN
cord-269011-230p8rsf	890	37	of	of	IN
cord-269011-230p8rsf	890	38	the	the	DT
cord-269011-230p8rsf	890	39	MHV	MHV	NNP
cord-269011-230p8rsf	890	40	-	-	HYPH
cord-269011-230p8rsf	890	41	A59	A59	NNP
cord-269011-230p8rsf	890	42	spike	spike	NN
cord-269011-230p8rsf	890	43	protein	protein	NN
cord-269011-230p8rsf	890	44	on	on	IN
cord-269011-230p8rsf	890	45	cell	cell	NN
cord-269011-230p8rsf	890	46	fusion	fusion	NN
cord-269011-230p8rsf	890	47	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	890	48	-	-	HYPH
cord-269011-230p8rsf	890	49	induced	induce	VBN
cord-269011-230p8rsf	890	50	membrane	membrane	NN
cord-269011-230p8rsf	890	51	fusion	fusion	NN
cord-269011-230p8rsf	890	52	requires	require	VBZ
cord-269011-230p8rsf	890	53	the	the	DT
cord-269011-230p8rsf	890	54	cysteine	cysteine	JJ
cord-269011-230p8rsf	890	55	-	-	HYPH
cord-269011-230p8rsf	890	56	rich	rich	JJ
cord-269011-230p8rsf	890	57	domain	domain	NN
cord-269011-230p8rsf	890	58	in	in	IN
cord-269011-230p8rsf	890	59	the	the	DT
cord-269011-230p8rsf	890	60	spike	spike	NN
cord-269011-230p8rsf	890	61	protein	protein	NN
cord-269011-230p8rsf	890	62	Cis	Cis	NNP
cord-269011-230p8rsf	890	63	requirement	requirement	NN
cord-269011-230p8rsf	890	64	for	for	IN
cord-269011-230p8rsf	890	65	N	n	CD
cord-269011-230p8rsf	890	66	-	-	HYPH
cord-269011-230p8rsf	890	67	specific	specific	JJ
cord-269011-230p8rsf	890	68	protein	protein	NN
cord-269011-230p8rsf	890	69	sequence	sequence	NN
cord-269011-230p8rsf	890	70	in	in	IN
cord-269011-230p8rsf	890	71	bovine	bovine	JJ
cord-269011-230p8rsf	890	72	coronavirus	coronavirus	NN
cord-269011-230p8rsf	890	73	defective	defective	JJ
cord-269011-230p8rsf	890	74	interfering	interfere	VBG
cord-269011-230p8rsf	890	75	RNA	RNA	NNP
cord-269011-230p8rsf	890	76	replication	replication	NN
cord-269011-230p8rsf	890	77	Induction	induction	NN
cord-269011-230p8rsf	890	78	of	of	IN
cord-269011-230p8rsf	890	79	a	a	DT
cord-269011-230p8rsf	890	80	interferon	interferon	NN
cord-269011-230p8rsf	890	81	by	by	IN
cord-269011-230p8rsf	890	82	transmissible	transmissible	JJ
cord-269011-230p8rsf	890	83	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	890	84	coronavirus	coronavirus	NN
cord-269011-230p8rsf	890	85	:	:	:
cord-269011-230p8rsf	891	1	Role	role	NN
cord-269011-230p8rsf	891	2	of	of	IN
cord-269011-230p8rsf	891	3	transmembrane	transmembrane	NNP
cord-269011-230p8rsf	891	4	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	891	5	E1	E1	NNP
cord-269011-230p8rsf	891	6	Morphogenesis	Morphogenesis	NNP
cord-269011-230p8rsf	891	7	of	of	IN
cord-269011-230p8rsf	891	8	avian	avian	JJ
cord-269011-230p8rsf	891	9	infectious	infectious	JJ
cord-269011-230p8rsf	891	10	bronchitis	bronchitis	NN
cord-269011-230p8rsf	891	11	virus	virus	NN
cord-269011-230p8rsf	891	12	in	in	IN
cord-269011-230p8rsf	891	13	primary	primary	JJ
cord-269011-230p8rsf	891	14	chick	chick	NN
cord-269011-230p8rsf	891	15	kidney	kidney	NN
cord-269011-230p8rsf	891	16	cells	cell	NNS
cord-269011-230p8rsf	891	17	Interaction	Interaction	NNP
cord-269011-230p8rsf	891	18	of	of	IN
cord-269011-230p8rsf	891	19	the	the	DT
cord-269011-230p8rsf	891	20	coronavirus	coronavirus	NN
cord-269011-230p8rsf	891	21	nucleoprotein	nucleoprotein	NNP
cord-269011-230p8rsf	891	22	with	with	IN
cord-269011-230p8rsf	891	23	nucleolar	nucleolar	JJ
cord-269011-230p8rsf	891	24	antigens	antigen	NNS
cord-269011-230p8rsf	891	25	and	and	CC
cord-269011-230p8rsf	891	26	the	the	DT
cord-269011-230p8rsf	891	27	host	host	NN
cord-269011-230p8rsf	891	28	cell	cell	NN
cord-269011-230p8rsf	891	29	Polypyrimidine	Polypyrimidine	NNP
cord-269011-230p8rsf	891	30	-	-	HYPH
cord-269011-230p8rsf	891	31	tract	tract	NN
cord-269011-230p8rsf	891	32	-	-	HYPH
cord-269011-230p8rsf	891	33	binding	bind	VBG
cord-269011-230p8rsf	891	34	protein	protein	NN
cord-269011-230p8rsf	891	35	affects	affect	VBZ
cord-269011-230p8rsf	891	36	transcription	transcription	NN
cord-269011-230p8rsf	891	37	but	but	CC
cord-269011-230p8rsf	891	38	not	not	RB
cord-269011-230p8rsf	891	39	translation	translation	NN
cord-269011-230p8rsf	891	40	of	of	IN
cord-269011-230p8rsf	891	41	mouse	mouse	NNP
cord-269011-230p8rsf	891	42	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	891	43	virus	virus	NN
cord-269011-230p8rsf	891	44	RNA	RNA	NNP
cord-269011-230p8rsf	891	45	Identification	Identification	NNP
cord-269011-230p8rsf	891	46	of	of	IN
cord-269011-230p8rsf	891	47	a	a	DT
cord-269011-230p8rsf	891	48	bovine	bovine	JJ
cord-269011-230p8rsf	891	49	coronavirus	coronavirus	NN
cord-269011-230p8rsf	891	50	packaging	packaging	NN
cord-269011-230p8rsf	891	51	signal	signal	NN
cord-269011-230p8rsf	891	52	Identification	identification	NN
cord-269011-230p8rsf	891	53	of	of	IN
cord-269011-230p8rsf	891	54	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	891	55	binding	bind	VBG
cord-269011-230p8rsf	891	56	sites	site	NNS
cord-269011-230p8rsf	891	57	within	within	IN
cord-269011-230p8rsf	891	58	coronavirus	coronavirus	NN
cord-269011-230p8rsf	891	59	-	-	HYPH
cord-269011-230p8rsf	891	60	defective	defective	JJ
cord-269011-230p8rsf	891	61	genomes	genome	NNS
cord-269011-230p8rsf	892	1	In	in	IN
cord-269011-230p8rsf	892	2	vitro	vitro	FW
cord-269011-230p8rsf	892	3	replication	replication	NN
cord-269011-230p8rsf	892	4	of	of	IN
cord-269011-230p8rsf	892	5	mouse	mouse	NN
cord-269011-230p8rsf	892	6	hepatitis	hepatitis	NN
cord-269011-230p8rsf	892	7	virus	virus	NN
cord-269011-230p8rsf	892	8	strain	strain	VBP
cord-269011-230p8rsf	892	9	A59	A59	NNP
cord-269011-230p8rsf	892	10	Hemagglutinin	Hemagglutinin	NNP
cord-269011-230p8rsf	892	11	-	-	HYPH
cord-269011-230p8rsf	892	12	esterase	esterase	NN
cord-269011-230p8rsf	892	13	,	,	,
cord-269011-230p8rsf	892	14	a	a	DT
cord-269011-230p8rsf	892	15	novel	novel	JJ
cord-269011-230p8rsf	892	16	structural	structural	JJ
cord-269011-230p8rsf	892	17	protein	protein	NN
cord-269011-230p8rsf	892	18	of	of	IN
cord-269011-230p8rsf	892	19	torovirus	torovirus	NNP
cord-269011-230p8rsf	893	1	Infectious	infectious	JJ
cord-269011-230p8rsf	893	2	bronchitis	bronchitis	NN
cord-269011-230p8rsf	893	3	virus	virus	NN
cord-269011-230p8rsf	893	4	E	e	NN
cord-269011-230p8rsf	893	5	protein	protein	NN
cord-269011-230p8rsf	893	6	is	be	VBZ
cord-269011-230p8rsf	893	7	targeted	target	VBN
cord-269011-230p8rsf	893	8	to	to	IN
cord-269011-230p8rsf	893	9	the	the	DT
cord-269011-230p8rsf	893	10	Golgi	Golgi	NNP
cord-269011-230p8rsf	893	11	complex	complex	NN
cord-269011-230p8rsf	893	12	and	and	CC
cord-269011-230p8rsf	893	13	directs	direct	VBZ
cord-269011-230p8rsf	893	14	release	release	NN
cord-269011-230p8rsf	893	15	of	of	IN
cord-269011-230p8rsf	893	16	virus	virus	NN
cord-269011-230p8rsf	893	17	-	-	HYPH
cord-269011-230p8rsf	893	18	like	like	JJ
cord-269011-230p8rsf	893	19	particles	particle	NNS
cord-269011-230p8rsf	894	1	The	the	DT
cord-269011-230p8rsf	894	2	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	894	3	tail	tail	NN
cord-269011-230p8rsf	894	4	of	of	IN
cord-269011-230p8rsf	894	5	infectious	infectious	JJ
cord-269011-230p8rsf	894	6	bronchitis	bronchitis	NN
cord-269011-230p8rsf	894	7	virus	virus	NN
cord-269011-230p8rsf	894	8	E	e	NN
cord-269011-230p8rsf	894	9	protein	protein	NN
cord-269011-230p8rsf	894	10	directs	direct	VBZ
cord-269011-230p8rsf	894	11	Golgi	Golgi	NNP
cord-269011-230p8rsf	894	12	targeting	target	VBG
cord-269011-230p8rsf	894	13	The	the	DT
cord-269011-230p8rsf	894	14	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	894	15	tails	tail	NNS
cord-269011-230p8rsf	894	16	of	of	IN
cord-269011-230p8rsf	894	17	infectious	infectious	JJ
cord-269011-230p8rsf	894	18	bronchitis	bronchitis	NN
cord-269011-230p8rsf	894	19	virus	virus	NN
cord-269011-230p8rsf	894	20	E	e	NN
cord-269011-230p8rsf	894	21	and	and	CC
cord-269011-230p8rsf	894	22	M	M	NNP
cord-269011-230p8rsf	894	23	proteins	protein	NNS
cord-269011-230p8rsf	894	24	mediate	mediate	VBP
cord-269011-230p8rsf	894	25	their	-PRON-	PRP$
cord-269011-230p8rsf	894	26	interaction	interaction	NN
cord-269011-230p8rsf	894	27	Heterologous	Heterologous	NNP
cord-269011-230p8rsf	894	28	gene	gene	NN
cord-269011-230p8rsf	894	29	expression	expression	NN
cord-269011-230p8rsf	894	30	from	from	IN
cord-269011-230p8rsf	894	31	transmissible	transmissible	JJ
cord-269011-230p8rsf	894	32	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	894	33	virus	virus	NN
cord-269011-230p8rsf	894	34	replicon	replicon	NN
cord-269011-230p8rsf	894	35	particles	particle	NNS
cord-269011-230p8rsf	894	36	Cis	Cis	NNP
cord-269011-230p8rsf	894	37	-	-	HYPH
cord-269011-230p8rsf	894	38	acting	acting	NN
cord-269011-230p8rsf	894	39	sequences	sequence	NNS
cord-269011-230p8rsf	894	40	required	require	VBN
cord-269011-230p8rsf	894	41	for	for	IN
cord-269011-230p8rsf	894	42	coronavirus	coronavirus	NN
cord-269011-230p8rsf	894	43	infectious	infectious	JJ
cord-269011-230p8rsf	894	44	bronchitis	bronchitis	NN
cord-269011-230p8rsf	894	45	virus	virus	NN
cord-269011-230p8rsf	894	46	defective	defective	JJ
cord-269011-230p8rsf	894	47	-	-	HYPH
cord-269011-230p8rsf	894	48	RNA	rna	NN
cord-269011-230p8rsf	894	49	replication	replication	NN
cord-269011-230p8rsf	894	50	and	and	CC
cord-269011-230p8rsf	894	51	packaging	package	VBG
cord-269011-230p8rsf	894	52	An	an	DT
cord-269011-230p8rsf	894	53	electron	electron	NN
cord-269011-230p8rsf	894	54	microscopic	microscopic	JJ
cord-269011-230p8rsf	894	55	study	study	NN
cord-269011-230p8rsf	894	56	of	of	IN
cord-269011-230p8rsf	894	57	the	the	DT
cord-269011-230p8rsf	894	58	development	development	NN
cord-269011-230p8rsf	894	59	of	of	IN
cord-269011-230p8rsf	894	60	a	a	DT
cord-269011-230p8rsf	894	61	mouse	mouse	NN
cord-269011-230p8rsf	894	62	hepatitis	hepatitis	NN
cord-269011-230p8rsf	894	63	virus	virus	NN
cord-269011-230p8rsf	894	64	in	in	IN
cord-269011-230p8rsf	894	65	tissue	tissue	NN
cord-269011-230p8rsf	894	66	culture	culture	NN
cord-269011-230p8rsf	894	67	cells	cell	NNS
cord-269011-230p8rsf	894	68	Ribonucleoprotein	Ribonucleoprotein	NNP
cord-269011-230p8rsf	894	69	of	of	IN
cord-269011-230p8rsf	894	70	avian	avian	JJ
cord-269011-230p8rsf	894	71	infectious	infectious	JJ
cord-269011-230p8rsf	894	72	bronchitis	bronchitis	NN
cord-269011-230p8rsf	894	73	virus	virus	NN
cord-269011-230p8rsf	894	74	Sequence	sequence	NN
cord-269011-230p8rsf	894	75	and	and	CC
cord-269011-230p8rsf	894	76	structure	structure	NN
cord-269011-230p8rsf	894	77	of	of	IN
cord-269011-230p8rsf	894	78	the	the	DT
cord-269011-230p8rsf	894	79	coronavirus	coronavirus	NN
cord-269011-230p8rsf	894	80	peplomer	peplomer	NNP
cord-269011-230p8rsf	894	81	protein	protein	NN
cord-269011-230p8rsf	894	82	Evidence	evidence	NN
cord-269011-230p8rsf	894	83	for	for	IN
cord-269011-230p8rsf	894	84	a	a	DT
cord-269011-230p8rsf	894	85	coiled	coil	VBN
cord-269011-230p8rsf	894	86	-	-	HYPH
cord-269011-230p8rsf	894	87	coil	coil	NN
cord-269011-230p8rsf	894	88	structure	structure	NN
cord-269011-230p8rsf	894	89	in	in	IN
cord-269011-230p8rsf	894	90	the	the	DT
cord-269011-230p8rsf	894	91	spike	spike	NN
cord-269011-230p8rsf	894	92	proteins	protein	NNS
cord-269011-230p8rsf	894	93	of	of	IN
cord-269011-230p8rsf	894	94	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	895	1	Stably	stably	RB
cord-269011-230p8rsf	895	2	expressed	express	VBD
cord-269011-230p8rsf	895	3	FIPV	FIPV	NNP
cord-269011-230p8rsf	895	4	peplomer	peplomer	NNP
cord-269011-230p8rsf	895	5	protein	protein	NN
cord-269011-230p8rsf	895	6	induces	induce	VBZ
cord-269011-230p8rsf	895	7	cell	cell	NN
cord-269011-230p8rsf	895	8	fusion	fusion	NN
cord-269011-230p8rsf	895	9	and	and	CC
cord-269011-230p8rsf	895	10	elicits	elicit	VBZ
cord-269011-230p8rsf	895	11	antibodies	antibody	NNS
cord-269011-230p8rsf	895	12	in	in	IN
cord-269011-230p8rsf	895	13	mice	mouse	NNS
cord-269011-230p8rsf	896	1	The	the	DT
cord-269011-230p8rsf	896	2	glycosylation	glycosylation	NN
cord-269011-230p8rsf	896	3	status	status	NN
cord-269011-230p8rsf	896	4	of	of	IN
cord-269011-230p8rsf	896	5	the	the	DT
cord-269011-230p8rsf	896	6	murine	murine	JJ
cord-269011-230p8rsf	896	7	hepatitis	hepatitis	NN
cord-269011-230p8rsf	896	8	coronavirus	coronavirus	NN
cord-269011-230p8rsf	896	9	M	M	NNP
cord-269011-230p8rsf	896	10	protein	protein	NN
cord-269011-230p8rsf	896	11	affects	affect	VBZ
cord-269011-230p8rsf	896	12	the	the	DT
cord-269011-230p8rsf	896	13	interferogenic	interferogenic	JJ
cord-269011-230p8rsf	896	14	capacity	capacity	NN
cord-269011-230p8rsf	896	15	of	of	IN
cord-269011-230p8rsf	896	16	the	the	DT
cord-269011-230p8rsf	896	17	virus	virus	NN
cord-269011-230p8rsf	896	18	in	in	IN
cord-269011-230p8rsf	896	19	vitro	vitro	FW
cord-269011-230p8rsf	896	20	and	and	CC
cord-269011-230p8rsf	896	21	its	-PRON-	PRP$
cord-269011-230p8rsf	896	22	ability	ability	NN
cord-269011-230p8rsf	896	23	to	to	TO
cord-269011-230p8rsf	896	24	replicate	replicate	VB
cord-269011-230p8rsf	896	25	in	in	IN
cord-269011-230p8rsf	896	26	the	the	DT
cord-269011-230p8rsf	896	27	liver	liver	NN
cord-269011-230p8rsf	896	28	but	but	CC
cord-269011-230p8rsf	896	29	not	not	RB
cord-269011-230p8rsf	896	30	the	the	DT
cord-269011-230p8rsf	896	31	brain	brain	NN
cord-269011-230p8rsf	896	32	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	896	33	particle	particle	NN
cord-269011-230p8rsf	896	34	assembly	assembly	NN
cord-269011-230p8rsf	896	35	:	:	:
cord-269011-230p8rsf	896	36	Primary	primary	JJ
cord-269011-230p8rsf	896	37	structure	structure	NN
cord-269011-230p8rsf	896	38	requirements	requirement	NNS
cord-269011-230p8rsf	896	39	of	of	IN
cord-269011-230p8rsf	896	40	the	the	DT
cord-269011-230p8rsf	896	41	membrane	membrane	NN
cord-269011-230p8rsf	896	42	protein	protein	NN
cord-269011-230p8rsf	897	1	The	the	DT
cord-269011-230p8rsf	897	2	groupspecific	groupspecific	NNP
cord-269011-230p8rsf	897	3	murine	murine	JJ
cord-269011-230p8rsf	897	4	coronavirus	coronavirus	NN
cord-269011-230p8rsf	897	5	genes	gene	NNS
cord-269011-230p8rsf	897	6	are	be	VBP
cord-269011-230p8rsf	897	7	not	not	RB
cord-269011-230p8rsf	897	8	essential	essential	JJ
cord-269011-230p8rsf	897	9	,	,	,
cord-269011-230p8rsf	897	10	but	but	CC
cord-269011-230p8rsf	897	11	their	-PRON-	PRP$
cord-269011-230p8rsf	897	12	deletion	deletion	NN
cord-269011-230p8rsf	897	13	,	,	,
cord-269011-230p8rsf	897	14	by	by	IN
cord-269011-230p8rsf	897	15	reverse	reverse	JJ
cord-269011-230p8rsf	897	16	genetics	genetic	NNS
cord-269011-230p8rsf	897	17	,	,	,
cord-269011-230p8rsf	897	18	is	be	VBZ
cord-269011-230p8rsf	897	19	attenuating	attenuate	VBG
cord-269011-230p8rsf	897	20	in	in	IN
cord-269011-230p8rsf	897	21	the	the	DT
cord-269011-230p8rsf	897	22	natural	natural	JJ
cord-269011-230p8rsf	897	23	host	host	NN
cord-269011-230p8rsf	897	24	Structural	structural	JJ
cord-269011-230p8rsf	897	25	requirements	requirement	NNS
cord-269011-230p8rsf	897	26	for	for	IN
cord-269011-230p8rsf	897	27	O	o	NN
cord-269011-230p8rsf	897	28	-	-	HYPH
cord-269011-230p8rsf	897	29	glycosylation	glycosylation	NN
cord-269011-230p8rsf	897	30	of	of	IN
cord-269011-230p8rsf	897	31	the	the	DT
cord-269011-230p8rsf	897	32	mouse	mouse	NN
cord-269011-230p8rsf	897	33	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	897	34	virus	virus	NN
cord-269011-230p8rsf	897	35	membrane	membrane	NN
cord-269011-230p8rsf	897	36	protein	protein	NN
cord-269011-230p8rsf	897	37	Mapping	mapping	NN
cord-269011-230p8rsf	897	38	of	of	IN
cord-269011-230p8rsf	897	39	the	the	DT
cord-269011-230p8rsf	897	40	coronavirus	coronavirus	NN
cord-269011-230p8rsf	897	41	membrane	membrane	NN
cord-269011-230p8rsf	897	42	protein	protein	NN
cord-269011-230p8rsf	897	43	domains	domain	NNS
cord-269011-230p8rsf	897	44	involved	involve	VBN
cord-269011-230p8rsf	897	45	in	in	IN
cord-269011-230p8rsf	897	46	interaction	interaction	NN
cord-269011-230p8rsf	897	47	with	with	IN
cord-269011-230p8rsf	897	48	the	the	DT
cord-269011-230p8rsf	897	49	spike	spike	NN
cord-269011-230p8rsf	897	50	protein	protein	NN
cord-269011-230p8rsf	897	51	Assembly	Assembly	NNP
cord-269011-230p8rsf	897	52	of	of	IN
cord-269011-230p8rsf	897	53	the	the	DT
cord-269011-230p8rsf	897	54	coronavirus	coronavirus	NN
cord-269011-230p8rsf	897	55	envelope	envelope	NN
cord-269011-230p8rsf	897	56	:	:	:
cord-269011-230p8rsf	898	1	Homotypic	Homotypic	NNP
cord-269011-230p8rsf	898	2	interactions	interaction	NNS
cord-269011-230p8rsf	898	3	between	between	IN
cord-269011-230p8rsf	898	4	the	the	DT
cord-269011-230p8rsf	898	5	M	M	NNP
cord-269011-230p8rsf	898	6	proteins	protein	NNS
cord-269011-230p8rsf	898	7	O	o	NN
cord-269011-230p8rsf	898	8	-	-	HYPH
cord-269011-230p8rsf	898	9	glycosylation	glycosylation	NN
cord-269011-230p8rsf	898	10	of	of	IN
cord-269011-230p8rsf	898	11	the	the	DT
cord-269011-230p8rsf	898	12	mouse	mouse	NN
cord-269011-230p8rsf	898	13	hepatitis	hepatitis	NN
cord-269011-230p8rsf	898	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	898	15	membrane	membrane	NN
cord-269011-230p8rsf	898	16	protein	protein	NN
cord-269011-230p8rsf	898	17	Cleavage	cleavage	NN
cord-269011-230p8rsf	898	18	inhibition	inhibition	NN
cord-269011-230p8rsf	898	19	of	of	IN
cord-269011-230p8rsf	898	20	the	the	DT
cord-269011-230p8rsf	898	21	murine	murine	JJ
cord-269011-230p8rsf	898	22	coronavirus	coronavirus	NN
cord-269011-230p8rsf	898	23	spike	spike	NN
cord-269011-230p8rsf	898	24	protein	protein	NN
cord-269011-230p8rsf	898	25	by	by	IN
cord-269011-230p8rsf	898	26	a	a	DT
cord-269011-230p8rsf	898	27	furin	furin	NN
cord-269011-230p8rsf	898	28	-	-	HYPH
cord-269011-230p8rsf	898	29	like	like	JJ
cord-269011-230p8rsf	898	30	enzyme	enzyme	NN
cord-269011-230p8rsf	898	31	affects	affect	VBZ
cord-269011-230p8rsf	898	32	cell	cell	NN
cord-269011-230p8rsf	898	33	-	-	HYPH
cord-269011-230p8rsf	898	34	cell	cell	NN
cord-269011-230p8rsf	898	35	but	but	CC
cord-269011-230p8rsf	898	36	not	not	RB
cord-269011-230p8rsf	898	37	virus	virus	NN
cord-269011-230p8rsf	898	38	-	-	HYPH
cord-269011-230p8rsf	898	39	cell	cell	NN
cord-269011-230p8rsf	898	40	fusion	fusion	NN
cord-269011-230p8rsf	899	1	The	the	DT
cord-269011-230p8rsf	899	2	genome	genome	NN
cord-269011-230p8rsf	899	3	organization	organization	NN
cord-269011-230p8rsf	899	4	of	of	IN
cord-269011-230p8rsf	899	5	the	the	DT
cord-269011-230p8rsf	899	6	nidovirales	nidovirale	NNS
cord-269011-230p8rsf	899	7	:	:	:
cord-269011-230p8rsf	899	8	Similarities	similarity	NNS
cord-269011-230p8rsf	899	9	and	and	CC
cord-269011-230p8rsf	899	10	differences	difference	NNS
cord-269011-230p8rsf	899	11	between	between	IN
cord-269011-230p8rsf	899	12	arteri-	arteri-	NN
cord-269011-230p8rsf	899	13	,	,	,
cord-269011-230p8rsf	899	14	toro-	toro-	NN
cord-269011-230p8rsf	899	15	,	,	,
cord-269011-230p8rsf	899	16	and	and	CC
cord-269011-230p8rsf	899	17	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	900	1	Aminopeptidase	Aminopeptidase	NNP
cord-269011-230p8rsf	900	2	N	N	NNP
cord-269011-230p8rsf	900	3	is	be	VBZ
cord-269011-230p8rsf	900	4	a	a	DT
cord-269011-230p8rsf	900	5	major	major	JJ
cord-269011-230p8rsf	900	6	receptor	receptor	NN
cord-269011-230p8rsf	900	7	for	for	IN
cord-269011-230p8rsf	900	8	the	the	DT
cord-269011-230p8rsf	900	9	entero	entero	NNP
cord-269011-230p8rsf	900	10	-	-	HYPH
cord-269011-230p8rsf	900	11	pathogenic	pathogenic	JJ
cord-269011-230p8rsf	900	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	901	1	TGEV	TGEV	NNP
cord-269011-230p8rsf	901	2	Further	further	JJ
cord-269011-230p8rsf	901	3	characterization	characterization	NN
cord-269011-230p8rsf	901	4	of	of	IN
cord-269011-230p8rsf	901	5	aminopeptidase	aminopeptidase	NN
cord-269011-230p8rsf	901	6	-	-	HYPH
cord-269011-230p8rsf	901	7	N	N	NNP
cord-269011-230p8rsf	901	8	as	as	IN
cord-269011-230p8rsf	901	9	a	a	DT
cord-269011-230p8rsf	901	10	receptor	receptor	NN
cord-269011-230p8rsf	901	11	for	for	IN
cord-269011-230p8rsf	901	12	coronaviruses	coronaviruses	NNP
cord-269011-230p8rsf	901	13	Assembly	Assembly	NNP
cord-269011-230p8rsf	901	14	of	of	IN
cord-269011-230p8rsf	901	15	coronavirus	coronavirus	NN
cord-269011-230p8rsf	901	16	spike	spike	NN
cord-269011-230p8rsf	901	17	protein	protein	NN
cord-269011-230p8rsf	901	18	into	into	IN
cord-269011-230p8rsf	901	19	trimers	trimer	NNS
cord-269011-230p8rsf	901	20	and	and	CC
cord-269011-230p8rsf	901	21	its	-PRON-	PRP$
cord-269011-230p8rsf	901	22	role	role	NN
cord-269011-230p8rsf	901	23	in	in	IN
cord-269011-230p8rsf	901	24	epitope	epitope	NN
cord-269011-230p8rsf	901	25	expression	expression	NN
cord-269011-230p8rsf	902	1	The	the	DT
cord-269011-230p8rsf	902	2	putative	putative	JJ
cord-269011-230p8rsf	902	3	helicase	helicase	NN
cord-269011-230p8rsf	902	4	of	of	IN
cord-269011-230p8rsf	902	5	the	the	DT
cord-269011-230p8rsf	902	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	902	7	mouse	mouse	NN
cord-269011-230p8rsf	902	8	hepatitis	hepatitis	NN
cord-269011-230p8rsf	902	9	virus	virus	NN
cord-269011-230p8rsf	902	10	is	be	VBZ
cord-269011-230p8rsf	902	11	processed	process	VBN
cord-269011-230p8rsf	902	12	from	from	IN
cord-269011-230p8rsf	902	13	the	the	DT
cord-269011-230p8rsf	902	14	replicase	replicase	NNP
cord-269011-230p8rsf	902	15	gene	gene	NNP
cord-269011-230p8rsf	902	16	polyprotein	polyprotein	NNP
cord-269011-230p8rsf	902	17	and	and	CC
cord-269011-230p8rsf	902	18	localizes	localize	VBZ
cord-269011-230p8rsf	902	19	in	in	IN
cord-269011-230p8rsf	902	20	complexes	complex	NNS
cord-269011-230p8rsf	902	21	that	that	WDT
cord-269011-230p8rsf	902	22	are	be	VBP
cord-269011-230p8rsf	902	23	active	active	JJ
cord-269011-230p8rsf	902	24	in	in	IN
cord-269011-230p8rsf	902	25	viral	viral	JJ
cord-269011-230p8rsf	902	26	RNA	RNA	NNP
cord-269011-230p8rsf	902	27	synthesis	synthesis	NN
cord-269011-230p8rsf	902	28	Monoclonal	Monoclonal	NNP
cord-269011-230p8rsf	902	29	antibodies	antibody	NNS
cord-269011-230p8rsf	902	30	to	to	IN
cord-269011-230p8rsf	902	31	bovine	bovine	JJ
cord-269011-230p8rsf	902	32	coronavirus	coronavirus	NN
cord-269011-230p8rsf	902	33	:	:	:
cord-269011-230p8rsf	902	34	Characteristics	characteristic	NNS
cord-269011-230p8rsf	902	35	and	and	CC
cord-269011-230p8rsf	902	36	topographical	topographical	JJ
cord-269011-230p8rsf	902	37	mapping	mapping	NN
cord-269011-230p8rsf	902	38	of	of	IN
cord-269011-230p8rsf	902	39	neutralizing	neutralize	VBG
cord-269011-230p8rsf	902	40	epitopes	epitope	NNS
cord-269011-230p8rsf	902	41	on	on	IN
cord-269011-230p8rsf	902	42	the	the	DT
cord-269011-230p8rsf	902	43	E2	E2	NNP
cord-269011-230p8rsf	902	44	and	and	CC
cord-269011-230p8rsf	902	45	E3	E3	NNP
cord-269011-230p8rsf	902	46	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	902	47	Folding	folding	NN
cord-269011-230p8rsf	902	48	and	and	CC
cord-269011-230p8rsf	902	49	assembly	assembly	NN
cord-269011-230p8rsf	902	50	of	of	IN
cord-269011-230p8rsf	902	51	viral	viral	JJ
cord-269011-230p8rsf	902	52	membrane	membrane	NN
cord-269011-230p8rsf	902	53	proteins	protein	NNS
cord-269011-230p8rsf	902	54	Cell	cell	NN
cord-269011-230p8rsf	902	55	tropism	tropism	NN
cord-269011-230p8rsf	902	56	and	and	CC
cord-269011-230p8rsf	902	57	expression	expression	NN
cord-269011-230p8rsf	902	58	of	of	IN
cord-269011-230p8rsf	902	59	mouse	mouse	NN
cord-269011-230p8rsf	902	60	hepatitis	hepatitis	NN
cord-269011-230p8rsf	902	61	viruses	virus	NNS
cord-269011-230p8rsf	902	62	(	(	-LRB-
cord-269011-230p8rsf	902	63	MHV	MHV	NNP
cord-269011-230p8rsf	902	64	)	)	-RRB-
cord-269011-230p8rsf	902	65	in	in	IN
cord-269011-230p8rsf	902	66	mouse	mouse	NN
cord-269011-230p8rsf	902	67	spinal	spinal	JJ
cord-269011-230p8rsf	902	68	cord	cord	NN
cord-269011-230p8rsf	902	69	cultures	culture	NNS
cord-269011-230p8rsf	903	1	Several	several	JJ
cord-269011-230p8rsf	903	2	members	member	NNS
cord-269011-230p8rsf	903	3	of	of	IN
cord-269011-230p8rsf	903	4	the	the	DT
cord-269011-230p8rsf	903	5	mouse	mouse	NN
cord-269011-230p8rsf	903	6	carcinoembryonic	carcinoembryonic	NNP
cord-269011-230p8rsf	903	7	antigen	antigen	NN
cord-269011-230p8rsf	903	8	-	-	HYPH
cord-269011-230p8rsf	903	9	related	relate	VBN
cord-269011-230p8rsf	903	10	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	903	11	family	family	NN
cord-269011-230p8rsf	903	12	are	be	VBP
cord-269011-230p8rsf	903	13	functional	functional	JJ
cord-269011-230p8rsf	903	14	receptors	receptor	NNS
cord-269011-230p8rsf	903	15	for	for	IN
cord-269011-230p8rsf	903	16	the	the	DT
cord-269011-230p8rsf	903	17	coronavirus	coronavirus	NN
cord-269011-230p8rsf	903	18	mouse	mouse	NN
cord-269011-230p8rsf	903	19	hepatitis	hepatitis	NN
cord-269011-230p8rsf	903	20	virus	virus	NN
cord-269011-230p8rsf	903	21	-	-	:
cord-269011-230p8rsf	903	22	A59	A59	NNP
cord-269011-230p8rsf	903	23	Cloning	cloning	NN
cord-269011-230p8rsf	903	24	of	of	IN
cord-269011-230p8rsf	903	25	the	the	DT
cord-269011-230p8rsf	903	26	mouse	mouse	NN
cord-269011-230p8rsf	903	27	hepatitis	hepatitis	NN
cord-269011-230p8rsf	903	28	virus	virus	NN
cord-269011-230p8rsf	903	29	(	(	-LRB-
cord-269011-230p8rsf	903	30	MHV	mhv	NN
cord-269011-230p8rsf	903	31	)	)	-RRB-
cord-269011-230p8rsf	903	32	receptor	receptor	NN
cord-269011-230p8rsf	903	33	:	:	:
cord-269011-230p8rsf	904	1	Expression	expression	NN
cord-269011-230p8rsf	904	2	in	in	IN
cord-269011-230p8rsf	904	3	human	human	JJ
cord-269011-230p8rsf	904	4	and	and	CC
cord-269011-230p8rsf	904	5	hamster	hamster	NN
cord-269011-230p8rsf	904	6	cell	cell	NN
cord-269011-230p8rsf	904	7	lines	line	NNS
cord-269011-230p8rsf	904	8	confers	confer	VBZ
cord-269011-230p8rsf	904	9	susceptibility	susceptibility	NN
cord-269011-230p8rsf	904	10	to	to	IN
cord-269011-230p8rsf	904	11	MHV	MHV	NNP
cord-269011-230p8rsf	905	1	The	the	DT
cord-269011-230p8rsf	905	2	viral	viral	JJ
cord-269011-230p8rsf	905	3	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	905	4	protein	protein	NN
cord-269011-230p8rsf	905	5	of	of	IN
cord-269011-230p8rsf	905	6	transmissible	transmissible	JJ
cord-269011-230p8rsf	905	7	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	905	8	coronavirus	coronavirus	NN
cord-269011-230p8rsf	905	9	(	(	-LRB-
cord-269011-230p8rsf	905	10	TGEV	TGEV	NNP
cord-269011-230p8rsf	905	11	)	)	-RRB-
cord-269011-230p8rsf	905	12	is	be	VBZ
cord-269011-230p8rsf	905	13	cleaved	cleave	VBN
cord-269011-230p8rsf	905	14	by	by	IN
cord-269011-230p8rsf	905	15	caspase-6	caspase-6	NNP
cord-269011-230p8rsf	906	1	and	and	CC
cord-269011-230p8rsf	906	2	-7	-7	NNP
cord-269011-230p8rsf	906	3	during	during	IN
cord-269011-230p8rsf	906	4	TGEV	TGEV	NNP
cord-269011-230p8rsf	906	5	-	-	HYPH
cord-269011-230p8rsf	906	6	induced	induce	VBN
cord-269011-230p8rsf	906	7	apoptosis	apoptosis	NN
cord-269011-230p8rsf	906	8	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	906	9	derived	derive	VBD
cord-269011-230p8rsf	906	10	expression	expression	NN
cord-269011-230p8rsf	906	11	systems	system	NNS
cord-269011-230p8rsf	906	12	Organization	Organization	NNP
cord-269011-230p8rsf	906	13	of	of	IN
cord-269011-230p8rsf	906	14	two	two	CD
cord-269011-230p8rsf	906	15	transmissible	transmissible	JJ
cord-269011-230p8rsf	906	16	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	906	17	coronavirus	coronavirus	NN
cord-269011-230p8rsf	906	18	membrane	membrane	NN
cord-269011-230p8rsf	906	19	protein	protein	NN
cord-269011-230p8rsf	906	20	topologies	topology	NNS
cord-269011-230p8rsf	906	21	within	within	IN
cord-269011-230p8rsf	906	22	the	the	DT
cord-269011-230p8rsf	906	23	virion	virion	NN
cord-269011-230p8rsf	906	24	and	and	CC
cord-269011-230p8rsf	906	25	core	core	NN
cord-269011-230p8rsf	906	26	Transmissible	transmissible	JJ
cord-269011-230p8rsf	906	27	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	906	28	coronavirus	coronavirus	NN
cord-269011-230p8rsf	906	29	packaging	packaging	NN
cord-269011-230p8rsf	906	30	signal	signal	NN
cord-269011-230p8rsf	906	31	is	be	VBZ
cord-269011-230p8rsf	906	32	located	locate	VBN
cord-269011-230p8rsf	906	33	at	at	IN
cord-269011-230p8rsf	906	34	the	the	DT
cord-269011-230p8rsf	906	35	5	5	CD
cord-269011-230p8rsf	906	36	0	0	CD
cord-269011-230p8rsf	906	37	end	end	NN
cord-269011-230p8rsf	906	38	of	of	IN
cord-269011-230p8rsf	906	39	the	the	DT
cord-269011-230p8rsf	906	40	virus	virus	NN
cord-269011-230p8rsf	906	41	genome	genome	NN
cord-269011-230p8rsf	907	1	The	the	DT
cord-269011-230p8rsf	907	2	membrane	membrane	NN
cord-269011-230p8rsf	907	3	M	M	NNP
cord-269011-230p8rsf	907	4	protein	protein	NN
cord-269011-230p8rsf	907	5	carboxy	carboxy	NN
cord-269011-230p8rsf	907	6	terminus	terminus	NN
cord-269011-230p8rsf	907	7	binds	bind	VBZ
cord-269011-230p8rsf	907	8	to	to	IN
cord-269011-230p8rsf	907	9	transmissible	transmissible	JJ
cord-269011-230p8rsf	907	10	gastroenteritis	gastroenteritis	JJ
cord-269011-230p8rsf	907	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	907	12	core	core	NN
cord-269011-230p8rsf	907	13	and	and	CC
cord-269011-230p8rsf	907	14	contributes	contribute	VBZ
cord-269011-230p8rsf	907	15	to	to	IN
cord-269011-230p8rsf	907	16	core	core	NN
cord-269011-230p8rsf	907	17	stability	stability	NN
cord-269011-230p8rsf	908	1	The	the	DT
cord-269011-230p8rsf	908	2	internal	internal	JJ
cord-269011-230p8rsf	908	3	open	open	JJ
cord-269011-230p8rsf	908	4	reading	reading	NN
cord-269011-230p8rsf	908	5	frame	frame	NN
cord-269011-230p8rsf	908	6	within	within	IN
cord-269011-230p8rsf	908	7	the	the	DT
cord-269011-230p8rsf	908	8	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	908	9	gene	gene	NN
cord-269011-230p8rsf	908	10	of	of	IN
cord-269011-230p8rsf	908	11	mouse	mouse	NNP
cord-269011-230p8rsf	908	12	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	908	13	virus	virus	NN
cord-269011-230p8rsf	908	14	encodes	encode	VBZ
cord-269011-230p8rsf	908	15	a	a	DT
cord-269011-230p8rsf	908	16	structural	structural	JJ
cord-269011-230p8rsf	908	17	protein	protein	NN
cord-269011-230p8rsf	908	18	that	that	WDT
cord-269011-230p8rsf	908	19	is	be	VBZ
cord-269011-230p8rsf	908	20	not	not	RB
cord-269011-230p8rsf	908	21	essential	essential	JJ
cord-269011-230p8rsf	908	22	for	for	IN
cord-269011-230p8rsf	908	23	viral	viral	JJ
cord-269011-230p8rsf	908	24	replication	replication	NN
cord-269011-230p8rsf	908	25	Analysis	analysis	NN
cord-269011-230p8rsf	908	26	of	of	IN
cord-269011-230p8rsf	908	27	constructed	construct	VBN
cord-269011-230p8rsf	908	28	E	e	NN
cord-269011-230p8rsf	908	29	gene	gene	NN
cord-269011-230p8rsf	908	30	mutants	mutant	NNS
cord-269011-230p8rsf	908	31	of	of	IN
cord-269011-230p8rsf	908	32	mouse	mouse	NNP
cord-269011-230p8rsf	908	33	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	908	34	virus	virus	NN
cord-269011-230p8rsf	909	1	confirms	confirm	VBZ
cord-269011-230p8rsf	909	2	a	a	DT
cord-269011-230p8rsf	909	3	pivotal	pivotal	JJ
cord-269011-230p8rsf	909	4	role	role	NN
cord-269011-230p8rsf	909	5	for	for	IN
cord-269011-230p8rsf	909	6	E	e	NN
cord-269011-230p8rsf	909	7	protein	protein	NN
cord-269011-230p8rsf	909	8	in	in	IN
cord-269011-230p8rsf	909	9	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	10	assembly	assembly	NN
cord-269011-230p8rsf	909	11	Identification	identification	NN
cord-269011-230p8rsf	909	12	and	and	CC
cord-269011-230p8rsf	909	13	characterization	characterization	NN
cord-269011-230p8rsf	909	14	of	of	IN
cord-269011-230p8rsf	909	15	a	a	DT
cord-269011-230p8rsf	909	16	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	17	packaging	packaging	NN
cord-269011-230p8rsf	909	18	signal	signal	NN
cord-269011-230p8rsf	909	19	Proteolytic	proteolytic	JJ
cord-269011-230p8rsf	909	20	cleavage	cleavage	NN
cord-269011-230p8rsf	909	21	of	of	IN
cord-269011-230p8rsf	909	22	the	the	DT
cord-269011-230p8rsf	909	23	E2	E2	NNP
cord-269011-230p8rsf	909	24	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	909	25	of	of	IN
cord-269011-230p8rsf	909	26	murine	murine	JJ
cord-269011-230p8rsf	909	27	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	28	:	:	:
cord-269011-230p8rsf	909	29	Host	host	NN
cord-269011-230p8rsf	909	30	-	-	HYPH
cord-269011-230p8rsf	909	31	dependent	dependent	JJ
cord-269011-230p8rsf	909	32	differences	difference	NNS
cord-269011-230p8rsf	909	33	in	in	IN
cord-269011-230p8rsf	909	34	proteolytic	proteolytic	JJ
cord-269011-230p8rsf	909	35	cleavage	cleavage	NN
cord-269011-230p8rsf	909	36	and	and	CC
cord-269011-230p8rsf	909	37	cell	cell	NN
cord-269011-230p8rsf	909	38	fusion	fusion	NN
cord-269011-230p8rsf	909	39	Interaction	Interaction	NNP
cord-269011-230p8rsf	909	40	of	of	IN
cord-269011-230p8rsf	909	41	mouse	mouse	NNP
cord-269011-230p8rsf	909	42	hepatitis	hepatitis	NN
cord-269011-230p8rsf	909	43	virus	virus	NN
cord-269011-230p8rsf	909	44	(	(	-LRB-
cord-269011-230p8rsf	909	45	MHV	MHV	NNP
cord-269011-230p8rsf	909	46	)	)	-RRB-
cord-269011-230p8rsf	909	47	spike	spike	NN
cord-269011-230p8rsf	909	48	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	909	49	with	with	IN
cord-269011-230p8rsf	909	50	receptor	receptor	NN
cord-269011-230p8rsf	909	51	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	909	52	MHVR	MHVR	NNP
cord-269011-230p8rsf	909	53	is	be	VBZ
cord-269011-230p8rsf	909	54	required	require	VBN
cord-269011-230p8rsf	909	55	for	for	IN
cord-269011-230p8rsf	909	56	infection	infection	NN
cord-269011-230p8rsf	909	57	with	with	IN
cord-269011-230p8rsf	909	58	an	an	DT
cord-269011-230p8rsf	909	59	MHV	MHV	NNP
cord-269011-230p8rsf	909	60	strain	strain	NN
cord-269011-230p8rsf	909	61	that	that	WDT
cord-269011-230p8rsf	909	62	expresses	express	VBZ
cord-269011-230p8rsf	909	63	the	the	DT
cord-269011-230p8rsf	909	64	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	909	65	-	-	HYPH
cord-269011-230p8rsf	909	66	esterase	esterase	NN
cord-269011-230p8rsf	909	67	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	909	68	A	a	DT
cord-269011-230p8rsf	909	69	role	role	NN
cord-269011-230p8rsf	909	70	for	for	IN
cord-269011-230p8rsf	909	71	naturally	naturally	RB
cord-269011-230p8rsf	909	72	occurring	occur	VBG
cord-269011-230p8rsf	909	73	variation	variation	NN
cord-269011-230p8rsf	909	74	of	of	IN
cord-269011-230p8rsf	909	75	the	the	DT
cord-269011-230p8rsf	909	76	murine	murine	JJ
cord-269011-230p8rsf	909	77	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	78	spike	spike	NN
cord-269011-230p8rsf	909	79	protein	protein	NN
cord-269011-230p8rsf	909	80	in	in	IN
cord-269011-230p8rsf	909	81	stabilizing	stabilize	VBG
cord-269011-230p8rsf	909	82	association	association	NN
cord-269011-230p8rsf	909	83	with	with	IN
cord-269011-230p8rsf	909	84	the	the	DT
cord-269011-230p8rsf	909	85	cellular	cellular	JJ
cord-269011-230p8rsf	909	86	receptor	receptor	NN
cord-269011-230p8rsf	909	87	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	909	88	spike	spike	NN
cord-269011-230p8rsf	909	89	proteins	protein	NNS
cord-269011-230p8rsf	909	90	in	in	IN
cord-269011-230p8rsf	909	91	viral	viral	JJ
cord-269011-230p8rsf	909	92	entry	entry	NN
cord-269011-230p8rsf	909	93	and	and	CC
cord-269011-230p8rsf	909	94	pathogenesis	pathogenesis	NN
cord-269011-230p8rsf	909	95	Cell	cell	NN
cord-269011-230p8rsf	909	96	receptor	receptor	NN
cord-269011-230p8rsf	909	97	-	-	HYPH
cord-269011-230p8rsf	909	98	independent	independent	JJ
cord-269011-230p8rsf	909	99	infection	infection	NN
cord-269011-230p8rsf	909	100	by	by	IN
cord-269011-230p8rsf	909	101	a	a	DT
cord-269011-230p8rsf	909	102	neurotropic	neurotropic	NNP
cord-269011-230p8rsf	909	103	murine	murine	JJ
cord-269011-230p8rsf	909	104	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	105	Alteration	Alteration	NNP
cord-269011-230p8rsf	909	106	of	of	IN
cord-269011-230p8rsf	909	107	the	the	DT
cord-269011-230p8rsf	909	108	pH	pH	NNP
cord-269011-230p8rsf	909	109	dependence	dependence	NN
cord-269011-230p8rsf	909	110	of	of	IN
cord-269011-230p8rsf	909	111	coronavirus	coronavirus	NN
cord-269011-230p8rsf	909	112	-	-	HYPH
cord-269011-230p8rsf	909	113	induced	induce	VBN
cord-269011-230p8rsf	909	114	cell	cell	NN
cord-269011-230p8rsf	909	115	fusion	fusion	NN
cord-269011-230p8rsf	910	1	:	:	:
cord-269011-230p8rsf	910	2	Effect	effect	NN
cord-269011-230p8rsf	910	3	of	of	IN
cord-269011-230p8rsf	910	4	mutations	mutation	NNS
cord-269011-230p8rsf	910	5	in	in	IN
cord-269011-230p8rsf	910	6	the	the	DT
cord-269011-230p8rsf	910	7	spike	spike	NN
cord-269011-230p8rsf	910	8	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	910	9	Virus	virus	NN
cord-269011-230p8rsf	910	10	maturation	maturation	NN
cord-269011-230p8rsf	910	11	by	by	IN
cord-269011-230p8rsf	910	12	budding	bud	VBG
cord-269011-230p8rsf	910	13	.	.	.
cord-269011-230p8rsf	911	1	Microbiol	Microbiol	NNP
cord-269011-230p8rsf	911	2	Defective	defective	JJ
cord-269011-230p8rsf	911	3	replication	replication	NN
cord-269011-230p8rsf	911	4	of	of	IN
cord-269011-230p8rsf	911	5	porcine	porcine	JJ
cord-269011-230p8rsf	911	6	transmissible	transmissible	JJ
cord-269011-230p8rsf	911	7	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	911	8	virus	virus	NN
cord-269011-230p8rsf	911	9	in	in	IN
cord-269011-230p8rsf	911	10	a	a	DT
cord-269011-230p8rsf	911	11	continuous	continuous	JJ
cord-269011-230p8rsf	911	12	cell	cell	NN
cord-269011-230p8rsf	911	13	line	line	NN
cord-269011-230p8rsf	911	14	Isolation	isolation	NN
cord-269011-230p8rsf	911	15	of	of	IN
cord-269011-230p8rsf	911	16	subviral	subviral	JJ
cord-269011-230p8rsf	911	17	components	component	NNS
cord-269011-230p8rsf	911	18	from	from	IN
cord-269011-230p8rsf	911	19	transmissible	transmissible	JJ
cord-269011-230p8rsf	911	20	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	911	21	virus	virus	NN
cord-269011-230p8rsf	911	22	Assembly	assembly	NN
cord-269011-230p8rsf	911	23	of	of	IN
cord-269011-230p8rsf	911	24	spikes	spike	NNS
cord-269011-230p8rsf	911	25	into	into	IN
cord-269011-230p8rsf	911	26	coronavirus	coronavirus	NN
cord-269011-230p8rsf	911	27	particles	particle	NNS
cord-269011-230p8rsf	911	28	is	be	VBZ
cord-269011-230p8rsf	911	29	mediated	mediate	VBN
cord-269011-230p8rsf	911	30	by	by	IN
cord-269011-230p8rsf	911	31	the	the	DT
cord-269011-230p8rsf	911	32	carboxy	carboxy	JJ
cord-269011-230p8rsf	911	33	-	-	HYPH
cord-269011-230p8rsf	911	34	terminal	terminal	NN
cord-269011-230p8rsf	911	35	domain	domain	NN
cord-269011-230p8rsf	911	36	of	of	IN
cord-269011-230p8rsf	911	37	the	the	DT
cord-269011-230p8rsf	911	38	spike	spike	NN
cord-269011-230p8rsf	911	39	protein	protein	NN
cord-269011-230p8rsf	911	40	Major	major	JJ
cord-269011-230p8rsf	911	41	receptor	receptor	NN
cord-269011-230p8rsf	911	42	-	-	HYPH
cord-269011-230p8rsf	911	43	binding	binding	NN
cord-269011-230p8rsf	911	44	and	and	CC
cord-269011-230p8rsf	911	45	neutralization	neutralization	NN
cord-269011-230p8rsf	911	46	determinants	determinant	NNS
cord-269011-230p8rsf	911	47	are	be	VBP
cord-269011-230p8rsf	911	48	located	locate	VBN
cord-269011-230p8rsf	911	49	within	within	IN
cord-269011-230p8rsf	911	50	the	the	DT
cord-269011-230p8rsf	911	51	same	same	JJ
cord-269011-230p8rsf	911	52	domain	domain	NN
cord-269011-230p8rsf	911	53	of	of	IN
cord-269011-230p8rsf	911	54	the	the	DT
cord-269011-230p8rsf	911	55	transmissible	transmissible	JJ
cord-269011-230p8rsf	911	56	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	911	57	virus	virus	NN
cord-269011-230p8rsf	911	58	(	(	-LRB-
cord-269011-230p8rsf	911	59	coronavirus	coronavirus	NN
cord-269011-230p8rsf	911	60	)	)	-RRB-
cord-269011-230p8rsf	912	1	spike	spike	NN
cord-269011-230p8rsf	912	2	protein	protein	NN
cord-269011-230p8rsf	912	3	TGEV	TGEV	NNP
cord-269011-230p8rsf	912	4	corona	corona	NN
cord-269011-230p8rsf	912	5	virus	virus	NN
cord-269011-230p8rsf	912	6	ORF4	ORF4	NNP
cord-269011-230p8rsf	912	7	encodes	encode	VBZ
cord-269011-230p8rsf	912	8	a	a	DT
cord-269011-230p8rsf	912	9	membrane	membrane	NN
cord-269011-230p8rsf	912	10	protein	protein	NN
cord-269011-230p8rsf	912	11	that	that	WDT
cord-269011-230p8rsf	912	12	is	be	VBZ
cord-269011-230p8rsf	912	13	incorporated	incorporate	VBN
cord-269011-230p8rsf	912	14	into	into	IN
cord-269011-230p8rsf	912	15	virions	virion	NNS
cord-269011-230p8rsf	913	1	Ultrastructural	ultrastructural	JJ
cord-269011-230p8rsf	913	2	characterization	characterization	NN
cord-269011-230p8rsf	913	3	of	of	IN
cord-269011-230p8rsf	913	4	SARS	SARS	NNP
cord-269011-230p8rsf	913	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	913	6	RNA	RNA	NNP
cord-269011-230p8rsf	913	7	replication	replication	NN
cord-269011-230p8rsf	913	8	of	of	IN
cord-269011-230p8rsf	913	9	mouse	mouse	NN
cord-269011-230p8rsf	913	10	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	913	11	virus	virus	NN
cord-269011-230p8rsf	913	12	takes	take	VBZ
cord-269011-230p8rsf	913	13	place	place	NN
cord-269011-230p8rsf	913	14	at	at	IN
cord-269011-230p8rsf	913	15	double	double	JJ
cord-269011-230p8rsf	913	16	-	-	HYPH
cord-269011-230p8rsf	913	17	membrane	membrane	NN
cord-269011-230p8rsf	913	18	vesicles	vesicle	NNS
cord-269011-230p8rsf	914	1	Switching	switch	VBG
cord-269011-230p8rsf	914	2	species	species	NN
cord-269011-230p8rsf	914	3	tropism	tropism	NN
cord-269011-230p8rsf	914	4	:	:	:
cord-269011-230p8rsf	914	5	An	an	DT
cord-269011-230p8rsf	914	6	effective	effective	JJ
cord-269011-230p8rsf	914	7	way	way	NN
cord-269011-230p8rsf	914	8	to	to	TO
cord-269011-230p8rsf	914	9	manipulate	manipulate	VB
cord-269011-230p8rsf	914	10	the	the	DT
cord-269011-230p8rsf	914	11	feline	feline	JJ
cord-269011-230p8rsf	914	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	914	13	genome	genome	NN
cord-269011-230p8rsf	914	14	Live	live	RB
cord-269011-230p8rsf	915	1	,	,	,
cord-269011-230p8rsf	915	2	attenuated	attenuated	JJ
cord-269011-230p8rsf	915	3	coronavirus	coronavirus	NN
cord-269011-230p8rsf	915	4	vaccines	vaccine	NNS
cord-269011-230p8rsf	915	5	through	through	IN
cord-269011-230p8rsf	915	6	the	the	DT
cord-269011-230p8rsf	915	7	directed	direct	VBN
cord-269011-230p8rsf	915	8	deletion	deletion	NN
cord-269011-230p8rsf	915	9	of	of	IN
cord-269011-230p8rsf	915	10	group	group	NN
cord-269011-230p8rsf	915	11	-	-	HYPH
cord-269011-230p8rsf	915	12	specific	specific	JJ
cord-269011-230p8rsf	915	13	genes	gene	NNS
cord-269011-230p8rsf	915	14	provide	provide	VBP
cord-269011-230p8rsf	915	15	protection	protection	NN
cord-269011-230p8rsf	915	16	against	against	IN
cord-269011-230p8rsf	915	17	feline	feline	JJ
cord-269011-230p8rsf	915	18	infectious	infectious	JJ
cord-269011-230p8rsf	915	19	peritonitis	peritonitis	NN
cord-269011-230p8rsf	915	20	Growth	growth	NN
cord-269011-230p8rsf	915	21	and	and	CC
cord-269011-230p8rsf	915	22	intracellular	intracellular	JJ
cord-269011-230p8rsf	915	23	development	development	NN
cord-269011-230p8rsf	915	24	of	of	IN
cord-269011-230p8rsf	915	25	a	a	DT
cord-269011-230p8rsf	915	26	new	new	JJ
cord-269011-230p8rsf	915	27	respiratory	respiratory	JJ
cord-269011-230p8rsf	915	28	virus	virus	NN
cord-269011-230p8rsf	915	29	Analysis	Analysis	NNP
cord-269011-230p8rsf	915	30	of	of	IN
cord-269011-230p8rsf	915	31	multimerization	multimerization	NN
cord-269011-230p8rsf	915	32	of	of	IN
cord-269011-230p8rsf	915	33	the	the	DT
cord-269011-230p8rsf	915	34	SARS	SARS	NNP
cord-269011-230p8rsf	915	35	coronavirus	coronavirus	NN
cord-269011-230p8rsf	915	36	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	915	37	protein	protein	NN
cord-269011-230p8rsf	916	1	The	the	DT
cord-269011-230p8rsf	916	2	molecular	molecular	JJ
cord-269011-230p8rsf	916	3	genetics	genetic	NNS
cord-269011-230p8rsf	916	4	of	of	IN
cord-269011-230p8rsf	916	5	feline	feline	JJ
cord-269011-230p8rsf	916	6	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	916	7	:	:	:
cord-269011-230p8rsf	916	8	Comparative	comparative	JJ
cord-269011-230p8rsf	916	9	sequence	sequence	NN
cord-269011-230p8rsf	916	10	analysis	analysis	NN
cord-269011-230p8rsf	916	11	of	of	IN
cord-269011-230p8rsf	916	12	the	the	DT
cord-269011-230p8rsf	916	13	ORF7a/7b	ORF7a/7b	NNP
cord-269011-230p8rsf	916	14	transcription	transcription	NN
cord-269011-230p8rsf	916	15	unit	unit	NN
cord-269011-230p8rsf	916	16	of	of	IN
cord-269011-230p8rsf	916	17	different	different	JJ
cord-269011-230p8rsf	916	18	biotypes	biotype	NNS
cord-269011-230p8rsf	917	1	The	the	DT
cord-269011-230p8rsf	917	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	917	3	infectious	infectious	JJ
cord-269011-230p8rsf	917	4	bronchitis	bronchitis	NN
cord-269011-230p8rsf	917	5	virus	virus	NN
cord-269011-230p8rsf	917	6	nucleoprotein	nucleoprotein	NNP
cord-269011-230p8rsf	917	7	localizes	localize	VBZ
cord-269011-230p8rsf	917	8	to	to	IN
cord-269011-230p8rsf	917	9	the	the	DT
cord-269011-230p8rsf	917	10	nucleolus	nucleolus	NN
cord-269011-230p8rsf	917	11	Bovine	bovine	JJ
cord-269011-230p8rsf	917	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	1	mRNA	mRNA	NNP
cord-269011-230p8rsf	918	2	replication	replication	NN
cord-269011-230p8rsf	918	3	continues	continue	VBZ
cord-269011-230p8rsf	918	4	throughout	throughout	IN
cord-269011-230p8rsf	918	5	persistent	persistent	JJ
cord-269011-230p8rsf	918	6	infection	infection	NN
cord-269011-230p8rsf	918	7	in	in	IN
cord-269011-230p8rsf	918	8	cell	cell	NN
cord-269011-230p8rsf	918	9	culture	culture	NN
cord-269011-230p8rsf	918	10	Structural	structural	JJ
cord-269011-230p8rsf	918	11	proteins	protein	NNS
cord-269011-230p8rsf	918	12	of	of	IN
cord-269011-230p8rsf	918	13	human	human	JJ
cord-269011-230p8rsf	918	14	respiratory	respiratory	JJ
cord-269011-230p8rsf	918	15	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	16	OC43	OC43	NNP
cord-269011-230p8rsf	918	17	Synthesis	Synthesis	NNP
cord-269011-230p8rsf	918	18	and	and	CC
cord-269011-230p8rsf	918	19	processing	processing	NN
cord-269011-230p8rsf	918	20	of	of	IN
cord-269011-230p8rsf	918	21	the	the	DT
cord-269011-230p8rsf	918	22	bovine	bovine	JJ
cord-269011-230p8rsf	918	23	enteric	enteric	JJ
cord-269011-230p8rsf	918	24	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	25	haemagglutinin	haemagglutinin	NN
cord-269011-230p8rsf	918	26	protein	protein	NN
cord-269011-230p8rsf	918	27	Antigenic	antigenic	JJ
cord-269011-230p8rsf	918	28	relationships	relationship	NNS
cord-269011-230p8rsf	918	29	among	among	IN
cord-269011-230p8rsf	918	30	proteins	protein	NNS
cord-269011-230p8rsf	918	31	of	of	IN
cord-269011-230p8rsf	918	32	bovine	bovine	JJ
cord-269011-230p8rsf	918	33	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	34	,	,	,
cord-269011-230p8rsf	918	35	human	human	JJ
cord-269011-230p8rsf	918	36	respiratory	respiratory	JJ
cord-269011-230p8rsf	918	37	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	38	OC43	OC43	NNP
cord-269011-230p8rsf	918	39	,	,	,
cord-269011-230p8rsf	918	40	and	and	CC
cord-269011-230p8rsf	918	41	mouse	mouse	NN
cord-269011-230p8rsf	918	42	hepatitis	hepatitis	NN
cord-269011-230p8rsf	918	43	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	44	A59	A59	NNP
cord-269011-230p8rsf	918	45	Enteric	enteric	JJ
cord-269011-230p8rsf	918	46	infections	infection	NNS
cord-269011-230p8rsf	918	47	with	with	IN
cord-269011-230p8rsf	918	48	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	918	49	and	and	CC
cord-269011-230p8rsf	918	50	toroviruses	toroviruses	NNP
cord-269011-230p8rsf	918	51	Evolution	Evolution	NNP
cord-269011-230p8rsf	918	52	of	of	IN
cord-269011-230p8rsf	918	53	a	a	DT
cord-269011-230p8rsf	918	54	coronavirus	coronavirus	NN
cord-269011-230p8rsf	918	55	during	during	IN
cord-269011-230p8rsf	918	56	persistent	persistent	JJ
cord-269011-230p8rsf	918	57	infection	infection	NN
cord-269011-230p8rsf	919	1	in	in	IN
cord-269011-230p8rsf	919	2	vitro	vitro	FW
cord-269011-230p8rsf	920	1	Tunicamycin	Tunicamycin	NNP
cord-269011-230p8rsf	920	2	resistant	resistant	JJ
cord-269011-230p8rsf	920	3	glycosylation	glycosylation	NN
cord-269011-230p8rsf	920	4	of	of	IN
cord-269011-230p8rsf	920	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	920	6	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	920	7	:	:	:
cord-269011-230p8rsf	920	8	Demonstration	demonstration	NN
cord-269011-230p8rsf	920	9	of	of	IN
cord-269011-230p8rsf	920	10	a	a	DT
cord-269011-230p8rsf	920	11	novel	novel	JJ
cord-269011-230p8rsf	920	12	type	type	NN
cord-269011-230p8rsf	920	13	of	of	IN
cord-269011-230p8rsf	920	14	viral	viral	JJ
cord-269011-230p8rsf	920	15	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	920	16	Receptor	receptor	NN
cord-269011-230p8rsf	920	17	specificity	specificity	NN
cord-269011-230p8rsf	920	18	and	and	CC
cord-269011-230p8rsf	920	19	receptor	receptor	NN
cord-269011-230p8rsf	920	20	-	-	HYPH
cord-269011-230p8rsf	920	21	induced	induce	VBN
cord-269011-230p8rsf	920	22	conformational	conformational	JJ
cord-269011-230p8rsf	920	23	changes	change	NNS
cord-269011-230p8rsf	920	24	in	in	IN
cord-269011-230p8rsf	920	25	mouse	mouse	NN
cord-269011-230p8rsf	920	26	hepatitis	hepatitis	NN
cord-269011-230p8rsf	920	27	virus	virus	NN
cord-269011-230p8rsf	920	28	spike	spike	NN
cord-269011-230p8rsf	920	29	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	920	30	Structure	structure	NN
cord-269011-230p8rsf	920	31	of	of	IN
cord-269011-230p8rsf	920	32	the	the	DT
cord-269011-230p8rsf	920	33	N	n	CD
cord-269011-230p8rsf	920	34	-	-	HYPH
cord-269011-230p8rsf	920	35	terminal	terminal	NN
cord-269011-230p8rsf	920	36	RNA	RNA	NNP
cord-269011-230p8rsf	920	37	-	-	HYPH
cord-269011-230p8rsf	920	38	binding	bind	VBG
cord-269011-230p8rsf	920	39	domain	domain	NN
cord-269011-230p8rsf	920	40	of	of	IN
cord-269011-230p8rsf	920	41	the	the	DT
cord-269011-230p8rsf	920	42	SARS	SARS	NNP
cord-269011-230p8rsf	920	43	CoV	CoV	NNP
cord-269011-230p8rsf	920	44	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	920	45	protein	protein	NNP
cord-269011-230p8rsf	920	46	Structural	structural	JJ
cord-269011-230p8rsf	920	47	characterization	characterization	NN
cord-269011-230p8rsf	920	48	of	of	IN
cord-269011-230p8rsf	920	49	the	the	DT
cord-269011-230p8rsf	920	50	fusion	fusion	NN
cord-269011-230p8rsf	920	51	-	-	HYPH
cord-269011-230p8rsf	920	52	active	active	JJ
cord-269011-230p8rsf	920	53	complex	complex	NN
cord-269011-230p8rsf	920	54	of	of	IN
cord-269011-230p8rsf	920	55	severe	severe	JJ
cord-269011-230p8rsf	920	56	acute	acute	JJ
cord-269011-230p8rsf	920	57	respiratory	respiratory	JJ
cord-269011-230p8rsf	920	58	syndrome	syndrome	NN
cord-269011-230p8rsf	920	59	(	(	-LRB-
cord-269011-230p8rsf	920	60	SARS	SARS	NNP
cord-269011-230p8rsf	920	61	)	)	-RRB-
cord-269011-230p8rsf	921	1	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	2	Replication	replication	NN
cord-269011-230p8rsf	921	3	and	and	CC
cord-269011-230p8rsf	921	4	packaging	packaging	NN
cord-269011-230p8rsf	921	5	of	of	IN
cord-269011-230p8rsf	921	6	transmissible	transmissible	JJ
cord-269011-230p8rsf	921	7	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	921	8	coronavirusderived	coronavirusderive	VBN
cord-269011-230p8rsf	921	9	synthetic	synthetic	NN
cord-269011-230p8rsf	921	10	minigenomes	minigenomes	NNP
cord-269011-230p8rsf	921	11	Regulation	regulation	NN
cord-269011-230p8rsf	921	12	of	of	IN
cord-269011-230p8rsf	921	13	the	the	DT
cord-269011-230p8rsf	921	14	initiation	initiation	NN
cord-269011-230p8rsf	921	15	of	of	IN
cord-269011-230p8rsf	921	16	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	17	JHM	JHM	NNP
cord-269011-230p8rsf	921	18	infection	infection	NN
cord-269011-230p8rsf	921	19	in	in	IN
cord-269011-230p8rsf	921	20	primary	primary	JJ
cord-269011-230p8rsf	921	21	oligodendrocytes	oligodendrocyte	NNS
cord-269011-230p8rsf	921	22	and	and	CC
cord-269011-230p8rsf	921	23	L-2	L-2	NNP
cord-269011-230p8rsf	921	24	fibroblasts	fibroblast	NNS
cord-269011-230p8rsf	921	25	Isolation	isolation	NN
cord-269011-230p8rsf	921	26	and	and	CC
cord-269011-230p8rsf	921	27	morphology	morphology	NN
cord-269011-230p8rsf	921	28	of	of	IN
cord-269011-230p8rsf	921	29	the	the	DT
cord-269011-230p8rsf	921	30	internal	internal	JJ
cord-269011-230p8rsf	921	31	component	component	NN
cord-269011-230p8rsf	921	32	of	of	IN
cord-269011-230p8rsf	921	33	human	human	JJ
cord-269011-230p8rsf	921	34	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	35	,	,	,
cord-269011-230p8rsf	921	36	strain	strain	NN
cord-269011-230p8rsf	921	37	229E	229e	CD
cord-269011-230p8rsf	921	38	Deletions	deletion	NNS
cord-269011-230p8rsf	921	39	in	in	IN
cord-269011-230p8rsf	921	40	the	the	DT
cord-269011-230p8rsf	921	41	7a	7a	NN
cord-269011-230p8rsf	921	42	ORF	ORF	NNP
cord-269011-230p8rsf	921	43	of	of	IN
cord-269011-230p8rsf	921	44	feline	feline	JJ
cord-269011-230p8rsf	921	45	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	46	associated	associate	VBN
cord-269011-230p8rsf	921	47	with	with	IN
cord-269011-230p8rsf	921	48	an	an	DT
cord-269011-230p8rsf	921	49	epidemic	epidemic	NN
cord-269011-230p8rsf	921	50	of	of	IN
cord-269011-230p8rsf	921	51	feline	feline	JJ
cord-269011-230p8rsf	921	52	infectious	infectious	JJ
cord-269011-230p8rsf	921	53	peritonitis	peritonitis	NN
cord-269011-230p8rsf	921	54	Structure	structure	NN
cord-269011-230p8rsf	921	55	and	and	CC
cord-269011-230p8rsf	921	56	orientation	orientation	NN
cord-269011-230p8rsf	921	57	of	of	IN
cord-269011-230p8rsf	921	58	expressed	express	VBN
cord-269011-230p8rsf	921	59	bovine	bovine	JJ
cord-269011-230p8rsf	921	60	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	61	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	921	62	-	-	HYPH
cord-269011-230p8rsf	921	63	esterase	esterase	NN
cord-269011-230p8rsf	921	64	protein	protein	NN
cord-269011-230p8rsf	921	65	Assembled	assemble	VBD
cord-269011-230p8rsf	921	66	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	67	from	from	IN
cord-269011-230p8rsf	921	68	complementation	complementation	NN
cord-269011-230p8rsf	921	69	of	of	IN
cord-269011-230p8rsf	921	70	two	two	CD
cord-269011-230p8rsf	921	71	defective	defective	JJ
cord-269011-230p8rsf	921	72	interfering	interfere	VBG
cord-269011-230p8rsf	921	73	RNAs	rna	NNS
cord-269011-230p8rsf	921	74	Bovine	bovine	JJ
cord-269011-230p8rsf	921	75	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	76	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	921	77	protein	protein	NN
cord-269011-230p8rsf	921	78	Identification	identification	NN
cord-269011-230p8rsf	921	79	of	of	IN
cord-269011-230p8rsf	921	80	a	a	DT
cord-269011-230p8rsf	921	81	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	82	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	921	83	-	-	HYPH
cord-269011-230p8rsf	921	84	esterase	esterase	NN
cord-269011-230p8rsf	921	85	with	with	IN
cord-269011-230p8rsf	921	86	a	a	DT
cord-269011-230p8rsf	921	87	substrate	substrate	NN
cord-269011-230p8rsf	921	88	specificity	specificity	NN
cord-269011-230p8rsf	921	89	different	different	JJ
cord-269011-230p8rsf	921	90	from	from	IN
cord-269011-230p8rsf	921	91	those	those	DT
cord-269011-230p8rsf	921	92	of	of	IN
cord-269011-230p8rsf	921	93	influenza	influenza	NN
cord-269011-230p8rsf	921	94	C	c	NN
cord-269011-230p8rsf	921	95	virus	virus	NN
cord-269011-230p8rsf	921	96	and	and	CC
cord-269011-230p8rsf	921	97	bovine	bovine	JJ
cord-269011-230p8rsf	921	98	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	99	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	921	100	M	M	NNP
cord-269011-230p8rsf	921	101	proteins	protein	NNS
cord-269011-230p8rsf	921	102	accumulate	accumulate	VBP
cord-269011-230p8rsf	921	103	in	in	IN
cord-269011-230p8rsf	921	104	the	the	DT
cord-269011-230p8rsf	921	105	Golgi	Golgi	NNP
cord-269011-230p8rsf	921	106	complex	complex	NN
cord-269011-230p8rsf	921	107	beyond	beyond	IN
cord-269011-230p8rsf	921	108	the	the	DT
cord-269011-230p8rsf	921	109	site	site	NN
cord-269011-230p8rsf	921	110	of	of	IN
cord-269011-230p8rsf	921	111	virion	virion	NN
cord-269011-230p8rsf	921	112	budding	bud	VBG
cord-269011-230p8rsf	921	113	Repair	repair	NN
cord-269011-230p8rsf	921	114	and	and	CC
cord-269011-230p8rsf	921	115	mutagenesis	mutagenesis	NN
cord-269011-230p8rsf	921	116	of	of	IN
cord-269011-230p8rsf	921	117	the	the	DT
cord-269011-230p8rsf	921	118	genome	genome	NN
cord-269011-230p8rsf	921	119	of	of	IN
cord-269011-230p8rsf	921	120	a	a	DT
cord-269011-230p8rsf	921	121	deletion	deletion	NN
cord-269011-230p8rsf	921	122	mutant	mutant	NN
cord-269011-230p8rsf	921	123	of	of	IN
cord-269011-230p8rsf	921	124	the	the	DT
cord-269011-230p8rsf	921	125	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	126	mouse	mouse	NN
cord-269011-230p8rsf	921	127	hepatitis	hepatitis	NN
cord-269011-230p8rsf	921	128	virus	virus	NN
cord-269011-230p8rsf	921	129	by	by	IN
cord-269011-230p8rsf	921	130	targeted	target	VBN
cord-269011-230p8rsf	921	131	RNA	RNA	NNP
cord-269011-230p8rsf	921	132	recombination	recombination	NN
cord-269011-230p8rsf	921	133	Analysis	analysis	NN
cord-269011-230p8rsf	921	134	of	of	IN
cord-269011-230p8rsf	921	135	cellular	cellular	JJ
cord-269011-230p8rsf	921	136	receptors	receptor	NNS
cord-269011-230p8rsf	921	137	for	for	IN
cord-269011-230p8rsf	921	138	human	human	JJ
cord-269011-230p8rsf	921	139	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	140	OC43	OC43	NNP
cord-269011-230p8rsf	921	141	Variations	Variations	NNPS
cord-269011-230p8rsf	921	142	in	in	IN
cord-269011-230p8rsf	921	143	disparate	disparate	JJ
cord-269011-230p8rsf	921	144	regions	region	NNS
cord-269011-230p8rsf	921	145	of	of	IN
cord-269011-230p8rsf	921	146	the	the	DT
cord-269011-230p8rsf	921	147	murine	murine	JJ
cord-269011-230p8rsf	921	148	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	149	spike	spike	NN
cord-269011-230p8rsf	921	150	protein	protein	NN
cord-269011-230p8rsf	921	151	impact	impact	VBP
cord-269011-230p8rsf	921	152	the	the	DT
cord-269011-230p8rsf	921	153	initiation	initiation	NN
cord-269011-230p8rsf	921	154	of	of	IN
cord-269011-230p8rsf	921	155	membrane	membrane	NN
cord-269011-230p8rsf	921	156	fusion	fusion	NN
cord-269011-230p8rsf	921	157	Localization	localization	NN
cord-269011-230p8rsf	921	158	of	of	IN
cord-269011-230p8rsf	921	159	neutralizing	neutralize	VBG
cord-269011-230p8rsf	921	160	epitopes	epitope	NNS
cord-269011-230p8rsf	921	161	and	and	CC
cord-269011-230p8rsf	921	162	the	the	DT
cord-269011-230p8rsf	921	163	receptor	receptor	NN
cord-269011-230p8rsf	921	164	-	-	HYPH
cord-269011-230p8rsf	921	165	binding	bind	VBG
cord-269011-230p8rsf	921	166	site	site	NN
cord-269011-230p8rsf	921	167	within	within	IN
cord-269011-230p8rsf	921	168	the	the	DT
cord-269011-230p8rsf	921	169	amino	amino	NN
cord-269011-230p8rsf	921	170	-	-	HYPH
cord-269011-230p8rsf	921	171	terminal	terminal	NN
cord-269011-230p8rsf	921	172	330	330	CD
cord-269011-230p8rsf	921	173	amino	amino	NN
cord-269011-230p8rsf	921	174	acids	acid	NNS
cord-269011-230p8rsf	921	175	of	of	IN
cord-269011-230p8rsf	921	176	the	the	DT
cord-269011-230p8rsf	921	177	murine	murine	JJ
cord-269011-230p8rsf	921	178	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	179	spike	spike	NN
cord-269011-230p8rsf	921	180	protein	protein	NN
cord-269011-230p8rsf	921	181	Structural	structural	JJ
cord-269011-230p8rsf	921	182	and	and	CC
cord-269011-230p8rsf	921	183	functional	functional	JJ
cord-269011-230p8rsf	921	184	analysis	analysis	NN
cord-269011-230p8rsf	921	185	of	of	IN
cord-269011-230p8rsf	921	186	the	the	DT
cord-269011-230p8rsf	921	187	surface	surface	NN
cord-269011-230p8rsf	921	188	protein	protein	NN
cord-269011-230p8rsf	921	189	of	of	IN
cord-269011-230p8rsf	921	190	human	human	JJ
cord-269011-230p8rsf	921	191	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	192	OC43	OC43	NNP
cord-269011-230p8rsf	921	193	Genetic	genetic	JJ
cord-269011-230p8rsf	921	194	evidence	evidence	NN
cord-269011-230p8rsf	921	195	for	for	IN
cord-269011-230p8rsf	921	196	a	a	DT
cord-269011-230p8rsf	921	197	structural	structural	JJ
cord-269011-230p8rsf	921	198	interaction	interaction	NN
cord-269011-230p8rsf	921	199	between	between	IN
cord-269011-230p8rsf	921	200	the	the	DT
cord-269011-230p8rsf	921	201	carboxy	carboxy	JJ
cord-269011-230p8rsf	921	202	termini	terminus	NNS
cord-269011-230p8rsf	921	203	of	of	IN
cord-269011-230p8rsf	921	204	the	the	DT
cord-269011-230p8rsf	921	205	membrane	membrane	NN
cord-269011-230p8rsf	921	206	and	and	CC
cord-269011-230p8rsf	921	207	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	921	208	proteins	protein	NNS
cord-269011-230p8rsf	921	209	of	of	IN
cord-269011-230p8rsf	921	210	mouse	mouse	NN
cord-269011-230p8rsf	921	211	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	921	212	virus	virus	NN
cord-269011-230p8rsf	921	213	Retargeting	retargeting	NN
cord-269011-230p8rsf	921	214	of	of	IN
cord-269011-230p8rsf	921	215	coronavirus	coronavirus	NN
cord-269011-230p8rsf	921	216	by	by	IN
cord-269011-230p8rsf	921	217	substitution	substitution	NN
cord-269011-230p8rsf	921	218	of	of	IN
cord-269011-230p8rsf	921	219	the	the	DT
cord-269011-230p8rsf	921	220	spike	spike	NN
cord-269011-230p8rsf	921	221	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	921	222	ectodomain	ectodomain	NNP
cord-269011-230p8rsf	921	223	:	:	:
cord-269011-230p8rsf	922	1	Crossing	cross	VBG
cord-269011-230p8rsf	922	2	the	the	DT
cord-269011-230p8rsf	922	3	host	host	NN
cord-269011-230p8rsf	922	4	cell	cell	NN
cord-269011-230p8rsf	922	5	species	specie	NNS
cord-269011-230p8rsf	922	6	barrier	barrier	NN
cord-269011-230p8rsf	923	1	The	the	DT
cord-269011-230p8rsf	923	2	small	small	JJ
cord-269011-230p8rsf	923	3	envelope	envelope	NN
cord-269011-230p8rsf	923	4	protein	protein	NN
cord-269011-230p8rsf	923	5	E	e	NN
cord-269011-230p8rsf	923	6	is	be	VBZ
cord-269011-230p8rsf	923	7	not	not	RB
cord-269011-230p8rsf	923	8	essential	essential	JJ
cord-269011-230p8rsf	923	9	for	for	IN
cord-269011-230p8rsf	923	10	murine	murine	JJ
cord-269011-230p8rsf	923	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	923	12	replication	replication	NN
cord-269011-230p8rsf	923	13	RNA	rna	NN
cord-269011-230p8rsf	923	14	-	-	HYPH
cord-269011-230p8rsf	923	15	protein	protein	NN
cord-269011-230p8rsf	923	16	interactions	interaction	NNS
cord-269011-230p8rsf	923	17	in	in	IN
cord-269011-230p8rsf	923	18	the	the	DT
cord-269011-230p8rsf	923	19	regulation	regulation	NN
cord-269011-230p8rsf	923	20	of	of	IN
cord-269011-230p8rsf	923	21	coronavirus	coronavirus	NN
cord-269011-230p8rsf	923	22	RNA	RNA	NNP
cord-269011-230p8rsf	923	23	replication	replication	NN
cord-269011-230p8rsf	923	24	and	and	CC
cord-269011-230p8rsf	923	25	transcription	transcription	NN
cord-269011-230p8rsf	924	1	The	the	DT
cord-269011-230p8rsf	924	2	molecular	molecular	JJ
cord-269011-230p8rsf	924	3	biology	biology	NN
cord-269011-230p8rsf	924	4	of	of	IN
cord-269011-230p8rsf	924	5	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	925	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	925	2	:	:	:
cord-269011-230p8rsf	925	3	How	how	WRB
cord-269011-230p8rsf	925	4	a	a	DT
cord-269011-230p8rsf	925	5	large	large	JJ
cord-269011-230p8rsf	925	6	RNA	RNA	NNP
cord-269011-230p8rsf	925	7	viral	viral	JJ
cord-269011-230p8rsf	925	8	genome	genome	NN
cord-269011-230p8rsf	925	9	is	be	VBZ
cord-269011-230p8rsf	925	10	replicated	replicate	VBN
cord-269011-230p8rsf	925	11	and	and	CC
cord-269011-230p8rsf	925	12	transcribed	transcribe	VBN
cord-269011-230p8rsf	925	13	The	the	DT
cord-269011-230p8rsf	925	14	disruption	disruption	NN
cord-269011-230p8rsf	925	15	of	of	IN
cord-269011-230p8rsf	925	16	infectious	infectious	JJ
cord-269011-230p8rsf	925	17	bronchitis	bronchitis	NN
cord-269011-230p8rsf	925	18	virus	virus	NN
cord-269011-230p8rsf	925	19	(	(	-LRB-
cord-269011-230p8rsf	925	20	IBV-41	IBV-41	NNP
cord-269011-230p8rsf	925	21	strain	strain	NN
cord-269011-230p8rsf	925	22	)	)	-RRB-
cord-269011-230p8rsf	925	23	with	with	IN
cord-269011-230p8rsf	925	24	Triton	Triton	NNP
cord-269011-230p8rsf	925	25	X-100	x-100	IN
cord-269011-230p8rsf	925	26	detergent	detergent	NN
cord-269011-230p8rsf	926	1	Single	single	JJ
cord-269011-230p8rsf	926	2	amino	amino	NN
cord-269011-230p8rsf	926	3	acid	acid	NN
cord-269011-230p8rsf	926	4	changes	change	NNS
cord-269011-230p8rsf	926	5	in	in	IN
cord-269011-230p8rsf	926	6	the	the	DT
cord-269011-230p8rsf	926	7	viral	viral	JJ
cord-269011-230p8rsf	926	8	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	926	9	M	m	CD
cord-269011-230p8rsf	926	10	affect	affect	NN
cord-269011-230p8rsf	926	11	induction	induction	NN
cord-269011-230p8rsf	926	12	of	of	IN
cord-269011-230p8rsf	926	13	a	a	DT
cord-269011-230p8rsf	926	14	interferon	interferon	NN
cord-269011-230p8rsf	926	15	by	by	IN
cord-269011-230p8rsf	926	16	the	the	DT
cord-269011-230p8rsf	926	17	coronavirus	coronavirus	NN
cord-269011-230p8rsf	926	18	transmissible	transmissible	JJ
cord-269011-230p8rsf	926	19	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	926	20	virus	virus	NN
cord-269011-230p8rsf	927	1	The	the	DT
cord-269011-230p8rsf	927	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	927	3	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	927	4	protein	protein	NN
cord-269011-230p8rsf	927	5	Quaternary	Quaternary	NNP
cord-269011-230p8rsf	927	6	structure	structure	NN
cord-269011-230p8rsf	927	7	of	of	IN
cord-269011-230p8rsf	927	8	coronavirus	coronavirus	NN
cord-269011-230p8rsf	927	9	spikes	spike	NNS
cord-269011-230p8rsf	927	10	in	in	IN
cord-269011-230p8rsf	927	11	complex	complex	NN
cord-269011-230p8rsf	927	12	with	with	IN
cord-269011-230p8rsf	927	13	carcinoembryonic	carcinoembryonic	NNP
cord-269011-230p8rsf	927	14	antigen	antigen	NN
cord-269011-230p8rsf	927	15	-	-	HYPH
cord-269011-230p8rsf	927	16	related	relate	VBN
cord-269011-230p8rsf	927	17	cell	cell	NN
cord-269011-230p8rsf	927	18	adhesion	adhesion	NN
cord-269011-230p8rsf	927	19	molecule	molecule	NN
cord-269011-230p8rsf	927	20	cellular	cellular	JJ
cord-269011-230p8rsf	927	21	receptors	receptor	NNS
cord-269011-230p8rsf	928	1	Angiotensin	angiotensin	NN
cord-269011-230p8rsf	928	2	-	-	HYPH
cord-269011-230p8rsf	928	3	converting	convert	VBG
cord-269011-230p8rsf	928	4	enzyme	enzyme	NN
cord-269011-230p8rsf	928	5	2	2	CD
cord-269011-230p8rsf	928	6	is	be	VBZ
cord-269011-230p8rsf	928	7	a	a	DT
cord-269011-230p8rsf	928	8	functional	functional	JJ
cord-269011-230p8rsf	928	9	receptor	receptor	NN
cord-269011-230p8rsf	928	10	for	for	IN
cord-269011-230p8rsf	928	11	the	the	DT
cord-269011-230p8rsf	928	12	SARS	SARS	NNP
cord-269011-230p8rsf	928	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	928	14	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	928	15	defective	defective	JJ
cord-269011-230p8rsf	928	16	-	-	HYPH
cord-269011-230p8rsf	928	17	interfering	interfere	VBG
cord-269011-230p8rsf	928	18	RNA	RNA	NNP
cord-269011-230p8rsf	928	19	as	as	IN
cord-269011-230p8rsf	928	20	an	an	DT
cord-269011-230p8rsf	928	21	expression	expression	NN
cord-269011-230p8rsf	928	22	vector	vector	NN
cord-269011-230p8rsf	928	23	:	:	:
cord-269011-230p8rsf	928	24	The	the	DT
cord-269011-230p8rsf	928	25	generation	generation	NN
cord-269011-230p8rsf	928	26	of	of	IN
cord-269011-230p8rsf	928	27	a	a	DT
cord-269011-230p8rsf	928	28	pseudorecombinant	pseudorecombinant	JJ
cord-269011-230p8rsf	928	29	mouse	mouse	NN
cord-269011-230p8rsf	928	30	hepatitis	hepatitis	NN
cord-269011-230p8rsf	928	31	virus	virus	NN
cord-269011-230p8rsf	928	32	expressing	express	VBG
cord-269011-230p8rsf	928	33	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	928	34	-	-	HYPH
cord-269011-230p8rsf	928	35	esterase	esterase	NN
cord-269011-230p8rsf	929	1	The	the	DT
cord-269011-230p8rsf	929	2	missing	missing	JJ
cord-269011-230p8rsf	929	3	link	link	NN
cord-269011-230p8rsf	929	4	in	in	IN
cord-269011-230p8rsf	929	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	929	6	assembly	assembly	NN
cord-269011-230p8rsf	929	7	.	.	.
cord-269011-230p8rsf	930	1	Retention	retention	NN
cord-269011-230p8rsf	930	2	of	of	IN
cord-269011-230p8rsf	930	3	the	the	DT
cord-269011-230p8rsf	930	4	avian	avian	JJ
cord-269011-230p8rsf	930	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	930	6	infectious	infectious	JJ
cord-269011-230p8rsf	930	7	bronchitis	bronchitis	NN
cord-269011-230p8rsf	930	8	virus	virus	NN
cord-269011-230p8rsf	930	9	envelope	envelope	NN
cord-269011-230p8rsf	930	10	protein	protein	NN
cord-269011-230p8rsf	930	11	in	in	IN
cord-269011-230p8rsf	930	12	the	the	DT
cord-269011-230p8rsf	930	13	pre	pre	JJ
cord-269011-230p8rsf	930	14	-	-	JJ
cord-269011-230p8rsf	930	15	Golgi	golgi	JJ
cord-269011-230p8rsf	930	16	compartments	compartment	NNS
cord-269011-230p8rsf	930	17	and	and	CC
cord-269011-230p8rsf	930	18	physical	physical	JJ
cord-269011-230p8rsf	930	19	interaction	interaction	NN
cord-269011-230p8rsf	930	20	between	between	IN
cord-269011-230p8rsf	930	21	the	the	DT
cord-269011-230p8rsf	930	22	envelope	envelope	NN
cord-269011-230p8rsf	930	23	and	and	CC
cord-269011-230p8rsf	930	24	membrane	membrane	NN
cord-269011-230p8rsf	930	25	proteins	protein	NNS
cord-269011-230p8rsf	930	26	Probing	probe	VBG
cord-269011-230p8rsf	930	27	the	the	DT
cord-269011-230p8rsf	930	28	structure	structure	NN
cord-269011-230p8rsf	930	29	of	of	IN
cord-269011-230p8rsf	930	30	the	the	DT
cord-269011-230p8rsf	930	31	SARS	SARS	NNP
cord-269011-230p8rsf	930	32	coronavirus	coronavirus	NN
cord-269011-230p8rsf	930	33	using	use	VBG
cord-269011-230p8rsf	930	34	scanning	scan	VBG
cord-269011-230p8rsf	930	35	electron	electron	NN
cord-269011-230p8rsf	930	36	microscopy	microscopy	NNP
cord-269011-230p8rsf	930	37	Association	Association	NNP
cord-269011-230p8rsf	930	38	of	of	IN
cord-269011-230p8rsf	930	39	the	the	DT
cord-269011-230p8rsf	930	40	infectious	infectious	JJ
cord-269011-230p8rsf	930	41	bronchitis	bronchitis	NN
cord-269011-230p8rsf	930	42	virus	virus	NN
cord-269011-230p8rsf	930	43	3c	3c	NNP
cord-269011-230p8rsf	930	44	protein	protein	NN
cord-269011-230p8rsf	930	45	with	with	IN
cord-269011-230p8rsf	930	46	the	the	DT
cord-269011-230p8rsf	930	47	virion	virion	NN
cord-269011-230p8rsf	930	48	envelope	envelope	NN
cord-269011-230p8rsf	930	49	Interaction	Interaction	NNP
cord-269011-230p8rsf	930	50	between	between	IN
cord-269011-230p8rsf	930	51	heptad	heptad	NNP
cord-269011-230p8rsf	930	52	repeat	repeat	NN
cord-269011-230p8rsf	930	53	1	1	CD
cord-269011-230p8rsf	930	54	and	and	CC
cord-269011-230p8rsf	930	55	2	2	CD
cord-269011-230p8rsf	930	56	regions	region	NNS
cord-269011-230p8rsf	930	57	in	in	IN
cord-269011-230p8rsf	930	58	spike	spike	NN
cord-269011-230p8rsf	930	59	protein	protein	NN
cord-269011-230p8rsf	930	60	of	of	IN
cord-269011-230p8rsf	930	61	SARS	SARS	NNP
cord-269011-230p8rsf	930	62	-	-	HYPH
cord-269011-230p8rsf	930	63	associated	associate	VBN
cord-269011-230p8rsf	930	64	coronavirus	coronavirus	NN
cord-269011-230p8rsf	930	65	:	:	:
cord-269011-230p8rsf	930	66	Implications	implication	NNS
cord-269011-230p8rsf	930	67	for	for	IN
cord-269011-230p8rsf	930	68	virus	virus	NN
cord-269011-230p8rsf	930	69	fusogenic	fusogenic	JJ
cord-269011-230p8rsf	930	70	mechanism	mechanism	NN
cord-269011-230p8rsf	930	71	and	and	CC
cord-269011-230p8rsf	930	72	identification	identification	NN
cord-269011-230p8rsf	930	73	of	of	IN
cord-269011-230p8rsf	930	74	fusion	fusion	NN
cord-269011-230p8rsf	930	75	inhibitors	inhibitor	NNS
cord-269011-230p8rsf	930	76	O	o	NN
cord-269011-230p8rsf	930	77	-	-	HYPH
cord-269011-230p8rsf	930	78	glycosylation	glycosylation	NN
cord-269011-230p8rsf	930	79	of	of	IN
cord-269011-230p8rsf	930	80	the	the	DT
cord-269011-230p8rsf	930	81	coronavirus	coronavirus	NN
cord-269011-230p8rsf	930	82	M	M	NNP
cord-269011-230p8rsf	930	83	protein	protein	NN
cord-269011-230p8rsf	930	84	.	.	.
cord-269011-230p8rsf	931	1	Differential	differential	JJ
cord-269011-230p8rsf	931	2	localization	localization	NN
cord-269011-230p8rsf	931	3	of	of	IN
cord-269011-230p8rsf	931	4	sialyltransferases	sialyltransferase	NNS
cord-269011-230p8rsf	931	5	in	in	IN
cord-269011-230p8rsf	931	6	N	N	NNP
cord-269011-230p8rsf	931	7	-	-	:
cord-269011-230p8rsf	931	8	and	and	CC
cord-269011-230p8rsf	931	9	O	o	NN
cord-269011-230p8rsf	931	10	-	-	HYPH
cord-269011-230p8rsf	931	11	linked	link	VBN
cord-269011-230p8rsf	931	12	glycosylation	glycosylation	NN
cord-269011-230p8rsf	932	1	The	the	DT
cord-269011-230p8rsf	932	2	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	932	3	tail	tail	NN
cord-269011-230p8rsf	932	4	of	of	IN
cord-269011-230p8rsf	932	5	mouse	mouse	NN
cord-269011-230p8rsf	932	6	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	932	7	virus	virus	NN
cord-269011-230p8rsf	932	8	M	M	NNP
cord-269011-230p8rsf	932	9	protein	protein	NN
cord-269011-230p8rsf	932	10	is	be	VBZ
cord-269011-230p8rsf	932	11	essential	essential	JJ
cord-269011-230p8rsf	932	12	but	but	CC
cord-269011-230p8rsf	932	13	not	not	RB
cord-269011-230p8rsf	932	14	sufficient	sufficient	JJ
cord-269011-230p8rsf	932	15	for	for	IN
cord-269011-230p8rsf	932	16	its	-PRON-	PRP$
cord-269011-230p8rsf	932	17	retention	retention	NN
cord-269011-230p8rsf	932	18	in	in	IN
cord-269011-230p8rsf	932	19	the	the	DT
cord-269011-230p8rsf	932	20	Golgi	Golgi	NNP
cord-269011-230p8rsf	932	21	complex	complex	JJ
cord-269011-230p8rsf	932	22	Oligomerization	Oligomerization	NNP
cord-269011-230p8rsf	932	23	of	of	IN
cord-269011-230p8rsf	932	24	a	a	DT
cord-269011-230p8rsf	932	25	trans	trans	JJ
cord-269011-230p8rsf	932	26	-	-	NNP
cord-269011-230p8rsf	932	27	Golgi	Golgi	NNP
cord-269011-230p8rsf	932	28	/	/	SYM
cord-269011-230p8rsf	932	29	trans	trans	NNP
cord-269011-230p8rsf	932	30	-	-	NNP
cord-269011-230p8rsf	932	31	Golgi	Golgi	NNP
cord-269011-230p8rsf	932	32	network	network	NN
cord-269011-230p8rsf	932	33	retained	retain	VBD
cord-269011-230p8rsf	932	34	protein	protein	NN
cord-269011-230p8rsf	932	35	occurs	occur	VBZ
cord-269011-230p8rsf	932	36	in	in	IN
cord-269011-230p8rsf	932	37	the	the	DT
cord-269011-230p8rsf	932	38	Golgi	Golgi	NNP
cord-269011-230p8rsf	932	39	complex	complex	NN
cord-269011-230p8rsf	932	40	and	and	CC
cord-269011-230p8rsf	932	41	may	may	MD
cord-269011-230p8rsf	932	42	be	be	VB
cord-269011-230p8rsf	932	43	part	part	NN
cord-269011-230p8rsf	932	44	of	of	IN
cord-269011-230p8rsf	932	45	its	-PRON-	PRP$
cord-269011-230p8rsf	932	46	retention	retention	NN
cord-269011-230p8rsf	933	1	Intracellular	Intracellular	NNP
cord-269011-230p8rsf	933	2	targeting	target	VBG
cord-269011-230p8rsf	933	3	signals	signal	NNS
cord-269011-230p8rsf	933	4	contribute	contribute	VBP
cord-269011-230p8rsf	933	5	to	to	IN
cord-269011-230p8rsf	933	6	localization	localization	NN
cord-269011-230p8rsf	933	7	of	of	IN
cord-269011-230p8rsf	933	8	coronavirus	coronavirus	NN
cord-269011-230p8rsf	933	9	spike	spike	NN
cord-269011-230p8rsf	933	10	proteins	protein	NNS
cord-269011-230p8rsf	933	11	near	near	IN
cord-269011-230p8rsf	933	12	the	the	DT
cord-269011-230p8rsf	933	13	virus	virus	NN
cord-269011-230p8rsf	933	14	assembly	assembly	NN
cord-269011-230p8rsf	933	15	site	site	NN
cord-269011-230p8rsf	933	16	Amino	amino	NN
cord-269011-230p8rsf	933	17	acid	acid	NN
cord-269011-230p8rsf	933	18	substitutions	substitution	NNS
cord-269011-230p8rsf	933	19	within	within	IN
cord-269011-230p8rsf	933	20	the	the	DT
cord-269011-230p8rsf	933	21	leucine	leucine	NN
cord-269011-230p8rsf	933	22	zipper	zipper	NN
cord-269011-230p8rsf	933	23	domain	domain	NN
cord-269011-230p8rsf	933	24	of	of	IN
cord-269011-230p8rsf	933	25	the	the	DT
cord-269011-230p8rsf	933	26	murine	murine	JJ
cord-269011-230p8rsf	933	27	coronavirus	coronavirus	NN
cord-269011-230p8rsf	933	28	spike	spike	NN
cord-269011-230p8rsf	933	29	protein	protein	NN
cord-269011-230p8rsf	933	30	cause	cause	VBP
cord-269011-230p8rsf	933	31	defects	defect	NNS
cord-269011-230p8rsf	933	32	in	in	IN
cord-269011-230p8rsf	933	33	oligomerization	oligomerization	NN
cord-269011-230p8rsf	933	34	and	and	CC
cord-269011-230p8rsf	933	35	the	the	DT
cord-269011-230p8rsf	933	36	ability	ability	NN
cord-269011-230p8rsf	933	37	to	to	TO
cord-269011-230p8rsf	933	38	induce	induce	VB
cord-269011-230p8rsf	933	39	cell	cell	NN
cord-269011-230p8rsf	933	40	-	-	HYPH
cord-269011-230p8rsf	933	41	to	to	IN
cord-269011-230p8rsf	933	42	-	-	HYPH
cord-269011-230p8rsf	933	43	cell	cell	NN
cord-269011-230p8rsf	933	44	fusion	fusion	NN
cord-269011-230p8rsf	933	45	Roles	role	NNS
cord-269011-230p8rsf	933	46	in	in	IN
cord-269011-230p8rsf	933	47	cell	cell	NN
cord-269011-230p8rsf	933	48	-	-	HYPH
cord-269011-230p8rsf	933	49	to	to	IN
cord-269011-230p8rsf	933	50	-	-	HYPH
cord-269011-230p8rsf	933	51	cell	cell	NN
cord-269011-230p8rsf	933	52	fusion	fusion	NN
cord-269011-230p8rsf	933	53	of	of	IN
cord-269011-230p8rsf	933	54	two	two	CD
cord-269011-230p8rsf	933	55	conserved	conserved	JJ
cord-269011-230p8rsf	933	56	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	933	57	regions	region	NNS
cord-269011-230p8rsf	933	58	in	in	IN
cord-269011-230p8rsf	933	59	the	the	DT
cord-269011-230p8rsf	933	60	murine	murine	JJ
cord-269011-230p8rsf	933	61	coronavirus	coronavirus	NN
cord-269011-230p8rsf	933	62	spike	spike	NN
cord-269011-230p8rsf	933	63	protein	protein	NN
cord-269011-230p8rsf	933	64	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	933	65	gene	gene	NN
cord-269011-230p8rsf	933	66	expression	expression	NN
cord-269011-230p8rsf	933	67	Sequence	sequence	NN
cord-269011-230p8rsf	933	68	of	of	IN
cord-269011-230p8rsf	933	69	mouse	mouse	NN
cord-269011-230p8rsf	934	1	hepatitis	hepatitis	NN
cord-269011-230p8rsf	934	2	virus	virus	NN
cord-269011-230p8rsf	934	3	A59	A59	NNP
cord-269011-230p8rsf	934	4	mRNA	mRNA	NNP
cord-269011-230p8rsf	935	1	2	2	LS
cord-269011-230p8rsf	935	2	:	:	:
cord-269011-230p8rsf	935	3	Indications	indication	NNS
cord-269011-230p8rsf	935	4	for	for	IN
cord-269011-230p8rsf	935	5	RNA	rna	NN
cord-269011-230p8rsf	935	6	recombination	recombination	NN
cord-269011-230p8rsf	935	7	between	between	IN
cord-269011-230p8rsf	935	8	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	935	9	and	and	CC
cord-269011-230p8rsf	935	10	influenza	influenza	NN
cord-269011-230p8rsf	935	11	C	c	NN
cord-269011-230p8rsf	935	12	virus	virus	NN
cord-269011-230p8rsf	935	13	Characterization	characterization	NN
cord-269011-230p8rsf	935	14	of	of	IN
cord-269011-230p8rsf	935	15	two	two	CD
cord-269011-230p8rsf	935	16	temperature	temperature	NN
cord-269011-230p8rsf	935	17	-	-	HYPH
cord-269011-230p8rsf	935	18	sensitive	sensitive	JJ
cord-269011-230p8rsf	935	19	mutants	mutant	NNS
cord-269011-230p8rsf	935	20	of	of	IN
cord-269011-230p8rsf	935	21	coronavirus	coronavirus	NN
cord-269011-230p8rsf	935	22	mouse	mouse	NN
cord-269011-230p8rsf	935	23	hepatitis	hepatitis	NN
cord-269011-230p8rsf	935	24	virus	virus	NN
cord-269011-230p8rsf	935	25	strain	strain	VBP
cord-269011-230p8rsf	935	26	A59	A59	NNP
cord-269011-230p8rsf	935	27	with	with	IN
cord-269011-230p8rsf	935	28	maturation	maturation	NN
cord-269011-230p8rsf	935	29	defects	defect	NNS
cord-269011-230p8rsf	935	30	in	in	IN
cord-269011-230p8rsf	935	31	the	the	DT
cord-269011-230p8rsf	935	32	spike	spike	NN
cord-269011-230p8rsf	935	33	protein	protein	NN
cord-269011-230p8rsf	935	34	Ceramide	ceramide	NN
cord-269011-230p8rsf	935	35	accumulation	accumulation	NN
cord-269011-230p8rsf	935	36	uncovers	uncover	VBZ
cord-269011-230p8rsf	935	37	a	a	DT
cord-269011-230p8rsf	935	38	cycling	cycling	NN
cord-269011-230p8rsf	935	39	pathway	pathway	NN
cord-269011-230p8rsf	935	40	for	for	IN
cord-269011-230p8rsf	935	41	the	the	DT
cord-269011-230p8rsf	935	42	cis	cis	NNP
cord-269011-230p8rsf	935	43	-	-	HYPH
cord-269011-230p8rsf	935	44	Golgi	Golgi	NNP
cord-269011-230p8rsf	935	45	network	network	NN
cord-269011-230p8rsf	935	46	marker	marker	NN
cord-269011-230p8rsf	935	47	,	,	,
cord-269011-230p8rsf	935	48	infectious	infectious	JJ
cord-269011-230p8rsf	935	49	bronchitis	bronchitis	NN
cord-269011-230p8rsf	935	50	virus	virus	NN
cord-269011-230p8rsf	935	51	M	M	NNP
cord-269011-230p8rsf	935	52	protein	protein	NN
cord-269011-230p8rsf	935	53	Retention	Retention	NNP
cord-269011-230p8rsf	935	54	of	of	IN
cord-269011-230p8rsf	935	55	a	a	DT
cord-269011-230p8rsf	935	56	cis	cis	NNP
cord-269011-230p8rsf	935	57	Golgi	Golgi	NNP
cord-269011-230p8rsf	935	58	protein	protein	NN
cord-269011-230p8rsf	936	1	requires	require	VBZ
cord-269011-230p8rsf	936	2	polar	polar	JJ
cord-269011-230p8rsf	936	3	residues	residue	NNS
cord-269011-230p8rsf	936	4	on	on	IN
cord-269011-230p8rsf	936	5	one	one	CD
cord-269011-230p8rsf	936	6	face	face	NN
cord-269011-230p8rsf	936	7	of	of	IN
cord-269011-230p8rsf	936	8	a	a	DT
cord-269011-230p8rsf	936	9	predicted	predict	VBN
cord-269011-230p8rsf	936	10	a	a	DT
cord-269011-230p8rsf	936	11	-	-	HYPH
cord-269011-230p8rsf	936	12	helix	helix	NN
cord-269011-230p8rsf	936	13	in	in	IN
cord-269011-230p8rsf	936	14	the	the	DT
cord-269011-230p8rsf	936	15	transmembrane	transmembrane	NN
cord-269011-230p8rsf	936	16	domain	domain	NN
cord-269011-230p8rsf	937	1	The	the	DT
cord-269011-230p8rsf	937	2	E1	e1	NN
cord-269011-230p8rsf	937	3	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	937	4	of	of	IN
cord-269011-230p8rsf	937	5	an	an	DT
cord-269011-230p8rsf	937	6	avian	avian	JJ
cord-269011-230p8rsf	937	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	937	8	is	be	VBZ
cord-269011-230p8rsf	937	9	targeted	target	VBN
cord-269011-230p8rsf	937	10	to	to	IN
cord-269011-230p8rsf	937	11	the	the	DT
cord-269011-230p8rsf	937	12	cis	cis	NNP
cord-269011-230p8rsf	937	13	Golgi	Golgi	NNP
cord-269011-230p8rsf	937	14	complex	complex	NN
cord-269011-230p8rsf	937	15	A	a	DT
cord-269011-230p8rsf	937	16	specific	specific	JJ
cord-269011-230p8rsf	937	17	transmembrane	transmembrane	NN
cord-269011-230p8rsf	937	18	domain	domain	NN
cord-269011-230p8rsf	937	19	of	of	IN
cord-269011-230p8rsf	937	20	a	a	DT
cord-269011-230p8rsf	937	21	coronavirus	coronavirus	NN
cord-269011-230p8rsf	937	22	E1	e1	NN
cord-269011-230p8rsf	937	23	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	937	24	is	be	VBZ
cord-269011-230p8rsf	937	25	required	require	VBN
cord-269011-230p8rsf	937	26	for	for	IN
cord-269011-230p8rsf	937	27	its	-PRON-	PRP$
cord-269011-230p8rsf	937	28	retention	retention	NN
cord-269011-230p8rsf	937	29	in	in	IN
cord-269011-230p8rsf	937	30	the	the	DT
cord-269011-230p8rsf	937	31	Golgi	Golgi	NNP
cord-269011-230p8rsf	937	32	region	region	NN
cord-269011-230p8rsf	937	33	Ribonucleoprotein	Ribonucleoprotein	NNP
cord-269011-230p8rsf	937	34	-	-	HYPH
cord-269011-230p8rsf	937	35	like	like	JJ
cord-269011-230p8rsf	937	36	structures	structure	NNS
cord-269011-230p8rsf	937	37	from	from	IN
cord-269011-230p8rsf	937	38	coronavirus	coronavirus	NN
cord-269011-230p8rsf	937	39	particles	particle	NNS
cord-269011-230p8rsf	937	40	Two	two	CD
cord-269011-230p8rsf	937	41	particle	particle	NN
cord-269011-230p8rsf	937	42	types	type	NNS
cord-269011-230p8rsf	937	43	of	of	IN
cord-269011-230p8rsf	937	44	avian	avian	JJ
cord-269011-230p8rsf	937	45	infectious	infectious	JJ
cord-269011-230p8rsf	937	46	bronchitis	bronchitis	NN
cord-269011-230p8rsf	937	47	virus	virus	NN
cord-269011-230p8rsf	937	48	Release	Release	NNP
cord-269011-230p8rsf	937	49	of	of	IN
cord-269011-230p8rsf	937	50	coronavirus	coronavirus	NN
cord-269011-230p8rsf	937	51	E	e	NN
cord-269011-230p8rsf	937	52	protein	protein	NN
cord-269011-230p8rsf	937	53	in	in	IN
cord-269011-230p8rsf	937	54	membrane	membrane	NN
cord-269011-230p8rsf	937	55	vesicles	vesicle	NNS
cord-269011-230p8rsf	937	56	from	from	IN
cord-269011-230p8rsf	937	57	virus	virus	NN
cord-269011-230p8rsf	937	58	-	-	HYPH
cord-269011-230p8rsf	937	59	infected	infect	VBN
cord-269011-230p8rsf	937	60	cells	cell	NNS
cord-269011-230p8rsf	937	61	and	and	CC
cord-269011-230p8rsf	937	62	E	e	NN
cord-269011-230p8rsf	937	63	protein	protein	NN
cord-269011-230p8rsf	937	64	-	-	HYPH
cord-269011-230p8rsf	937	65	expressing	express	VBG
cord-269011-230p8rsf	937	66	cells	cell	NNS
cord-269011-230p8rsf	937	67	Membrane	membrane	NN
cord-269011-230p8rsf	937	68	topology	topology	NN
cord-269011-230p8rsf	937	69	of	of	IN
cord-269011-230p8rsf	937	70	coronavirus	coronavirus	NN
cord-269011-230p8rsf	937	71	E	e	NN
cord-269011-230p8rsf	937	72	protein	protein	NN
cord-269011-230p8rsf	937	73	Japanese	japanese	JJ
cord-269011-230p8rsf	937	74	encephalitis	encephalitis	JJ
cord-269011-230p8rsf	937	75	virus	virus	NN
cord-269011-230p8rsf	937	76	-	-	HYPH
cord-269011-230p8rsf	937	77	vaccinia	vaccinia	NN
cord-269011-230p8rsf	937	78	recombinants	recombinant	NNS
cord-269011-230p8rsf	937	79	produce	produce	VBP
cord-269011-230p8rsf	937	80	particulate	particulate	NN
cord-269011-230p8rsf	937	81	forms	form	NNS
cord-269011-230p8rsf	937	82	of	of	IN
cord-269011-230p8rsf	937	83	the	the	DT
cord-269011-230p8rsf	937	84	structural	structural	JJ
cord-269011-230p8rsf	937	85	membrane	membrane	NN
cord-269011-230p8rsf	937	86	proteins	protein	NNS
cord-269011-230p8rsf	937	87	and	and	CC
cord-269011-230p8rsf	937	88	induce	induce	VB
cord-269011-230p8rsf	937	89	high	high	JJ
cord-269011-230p8rsf	937	90	levels	level	NNS
cord-269011-230p8rsf	937	91	of	of	IN
cord-269011-230p8rsf	937	92	protection	protection	NN
cord-269011-230p8rsf	937	93	against	against	IN
cord-269011-230p8rsf	937	94	lethal	lethal	JJ
cord-269011-230p8rsf	937	95	JEV	JEV	NNP
cord-269011-230p8rsf	937	96	infection	infection	NN
cord-269011-230p8rsf	938	1	In	in	IN
cord-269011-230p8rsf	938	2	vivo	vivo	NN
cord-269011-230p8rsf	938	3	and	and	CC
cord-269011-230p8rsf	938	4	in	in	IN
cord-269011-230p8rsf	938	5	vitro	vitro	FW
cord-269011-230p8rsf	938	6	models	model	NNS
cord-269011-230p8rsf	938	7	of	of	IN
cord-269011-230p8rsf	938	8	demyelinating	demyelinate	VBG
cord-269011-230p8rsf	938	9	diseases	disease	NNS
cord-269011-230p8rsf	938	10	.	.	.
cord-269011-230p8rsf	939	1	V.	V.	NNP
cord-269011-230p8rsf	939	2	Comparison	Comparison	NNP
cord-269011-230p8rsf	939	3	of	of	IN
cord-269011-230p8rsf	939	4	the	the	DT
cord-269011-230p8rsf	939	5	assembly	assembly	NNP
cord-269011-230p8rsf	939	6	of	of	IN
cord-269011-230p8rsf	939	7	mouse	mouse	NNP
cord-269011-230p8rsf	939	8	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	939	9	virus	virus	NN
cord-269011-230p8rsf	939	10	,	,	,
cord-269011-230p8rsf	939	11	strain	strain	NN
cord-269011-230p8rsf	939	12	JHM	JHM	NNP
cord-269011-230p8rsf	939	13	,	,	,
cord-269011-230p8rsf	939	14	in	in	IN
cord-269011-230p8rsf	939	15	two	two	CD
cord-269011-230p8rsf	939	16	murine	murine	JJ
cord-269011-230p8rsf	939	17	cell	cell	NN
cord-269011-230p8rsf	939	18	lines	line	NNS
cord-269011-230p8rsf	939	19	Localization	Localization	NNP
cord-269011-230p8rsf	939	20	of	of	IN
cord-269011-230p8rsf	939	21	an	an	DT
cord-269011-230p8rsf	939	22	RNA	rna	NN
cord-269011-230p8rsf	939	23	-	-	HYPH
cord-269011-230p8rsf	939	24	binding	bind	VBG
cord-269011-230p8rsf	939	25	domain	domain	NN
cord-269011-230p8rsf	939	26	in	in	IN
cord-269011-230p8rsf	939	27	the	the	DT
cord-269011-230p8rsf	939	28	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	939	29	protein	protein	NN
cord-269011-230p8rsf	939	30	of	of	IN
cord-269011-230p8rsf	939	31	the	the	DT
cord-269011-230p8rsf	939	32	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	33	mouse	mouse	NN
cord-269011-230p8rsf	939	34	hepatitis	hepatitis	NN
cord-269011-230p8rsf	939	35	virus	virus	NN
cord-269011-230p8rsf	939	36	Reverse	Reverse	NNP
cord-269011-230p8rsf	939	37	genetics	genetic	NNS
cord-269011-230p8rsf	939	38	of	of	IN
cord-269011-230p8rsf	939	39	the	the	DT
cord-269011-230p8rsf	939	40	largest	large	JJS
cord-269011-230p8rsf	939	41	RNA	RNA	NNP
cord-269011-230p8rsf	939	42	viruses	virus	NNS
cord-269011-230p8rsf	939	43	Receptor	receptor	NN
cord-269011-230p8rsf	939	44	-	-	HYPH
cord-269011-230p8rsf	939	45	induced	induce	VBN
cord-269011-230p8rsf	939	46	conformational	conformational	JJ
cord-269011-230p8rsf	939	47	changes	change	NNS
cord-269011-230p8rsf	939	48	of	of	IN
cord-269011-230p8rsf	939	49	murine	murine	JJ
cord-269011-230p8rsf	939	50	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	51	spike	spike	NN
cord-269011-230p8rsf	939	52	protein	protein	NN
cord-269011-230p8rsf	939	53	Membrane	membrane	NN
cord-269011-230p8rsf	939	54	integration	integration	NN
cord-269011-230p8rsf	939	55	and	and	CC
cord-269011-230p8rsf	939	56	intracellular	intracellular	JJ
cord-269011-230p8rsf	939	57	transport	transport	NN
cord-269011-230p8rsf	939	58	of	of	IN
cord-269011-230p8rsf	939	59	the	the	DT
cord-269011-230p8rsf	939	60	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	61	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	939	62	E1	E1	NNP
cord-269011-230p8rsf	939	63	,	,	,
cord-269011-230p8rsf	939	64	a	a	DT
cord-269011-230p8rsf	939	65	class	class	NN
cord-269011-230p8rsf	939	66	III	iii	CD
cord-269011-230p8rsf	939	67	membrane	membrane	NN
cord-269011-230p8rsf	939	68	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	939	69	N	n	CD
cord-269011-230p8rsf	939	70	-	-	HYPH
cord-269011-230p8rsf	939	71	terminal	terminal	NN
cord-269011-230p8rsf	939	72	domain	domain	NN
cord-269011-230p8rsf	939	73	of	of	IN
cord-269011-230p8rsf	939	74	the	the	DT
cord-269011-230p8rsf	939	75	murine	murine	JJ
cord-269011-230p8rsf	939	76	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	77	receptor	receptor	NN
cord-269011-230p8rsf	939	78	CEACAM1	CEACAM1	NNP
cord-269011-230p8rsf	939	79	is	be	VBZ
cord-269011-230p8rsf	939	80	responsible	responsible	JJ
cord-269011-230p8rsf	939	81	for	for	IN
cord-269011-230p8rsf	939	82	fusogenic	fusogenic	JJ
cord-269011-230p8rsf	939	83	activation	activation	NN
cord-269011-230p8rsf	939	84	and	and	CC
cord-269011-230p8rsf	939	85	conformational	conformational	JJ
cord-269011-230p8rsf	939	86	changes	change	NNS
cord-269011-230p8rsf	939	87	of	of	IN
cord-269011-230p8rsf	939	88	the	the	DT
cord-269011-230p8rsf	939	89	spike	spike	NN
cord-269011-230p8rsf	939	90	protein	protein	NN
cord-269011-230p8rsf	939	91	Endosomal	Endosomal	NNP
cord-269011-230p8rsf	939	92	association	association	NN
cord-269011-230p8rsf	939	93	of	of	IN
cord-269011-230p8rsf	939	94	a	a	DT
cord-269011-230p8rsf	939	95	protein	protein	NN
cord-269011-230p8rsf	939	96	phosphatase	phosphatase	NN
cord-269011-230p8rsf	939	97	with	with	IN
cord-269011-230p8rsf	939	98	high	high	JJ
cord-269011-230p8rsf	939	99	dephosphorylating	dephosphorylating	NN
cord-269011-230p8rsf	939	100	activity	activity	NN
cord-269011-230p8rsf	939	101	against	against	IN
cord-269011-230p8rsf	939	102	a	a	DT
cord-269011-230p8rsf	939	103	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	104	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	105	protein	protein	NN
cord-269011-230p8rsf	939	106	Identification	identification	NN
cord-269011-230p8rsf	939	107	of	of	IN
cord-269011-230p8rsf	939	108	a	a	DT
cord-269011-230p8rsf	939	109	specific	specific	JJ
cord-269011-230p8rsf	939	110	interaction	interaction	NN
cord-269011-230p8rsf	939	111	between	between	IN
cord-269011-230p8rsf	939	112	the	the	DT
cord-269011-230p8rsf	939	113	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	114	mouse	mouse	NN
cord-269011-230p8rsf	939	115	hepatitis	hepatitis	NN
cord-269011-230p8rsf	939	116	virus	virus	NN
cord-269011-230p8rsf	939	117	A59	A59	NNP
cord-269011-230p8rsf	939	118	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	119	protein	protein	NN
cord-269011-230p8rsf	939	120	and	and	CC
cord-269011-230p8rsf	939	121	packaging	packaging	NN
cord-269011-230p8rsf	939	122	signal	signal	NN
cord-269011-230p8rsf	939	123	Sequence	sequence	NN
cord-269011-230p8rsf	939	124	analysis	analysis	NN
cord-269011-230p8rsf	939	125	of	of	IN
cord-269011-230p8rsf	939	126	the	the	DT
cord-269011-230p8rsf	939	127	membrane	membrane	NN
cord-269011-230p8rsf	939	128	protein	protein	NN
cord-269011-230p8rsf	939	129	gene	gene	NN
cord-269011-230p8rsf	939	130	of	of	IN
cord-269011-230p8rsf	939	131	human	human	JJ
cord-269011-230p8rsf	939	132	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	133	OC43	OC43	NNP
cord-269011-230p8rsf	939	134	and	and	CC
cord-269011-230p8rsf	939	135	evidence	evidence	NN
cord-269011-230p8rsf	939	136	for	for	IN
cord-269011-230p8rsf	939	137	O	o	NN
cord-269011-230p8rsf	939	138	-	-	HYPH
cord-269011-230p8rsf	939	139	glycosylation	glycosylation	NN
cord-269011-230p8rsf	939	140	Nucleocapsid	nucleocapsid	JJ
cord-269011-230p8rsf	939	141	-	-	HYPH
cord-269011-230p8rsf	939	142	independent	independent	JJ
cord-269011-230p8rsf	939	143	specific	specific	JJ
cord-269011-230p8rsf	939	144	viral	viral	JJ
cord-269011-230p8rsf	939	145	RNA	RNA	NNP
cord-269011-230p8rsf	939	146	packaging	packaging	NN
cord-269011-230p8rsf	939	147	via	via	IN
cord-269011-230p8rsf	939	148	viral	viral	JJ
cord-269011-230p8rsf	939	149	envelope	envelope	NN
cord-269011-230p8rsf	939	150	protein	protein	NN
cord-269011-230p8rsf	939	151	and	and	CC
cord-269011-230p8rsf	939	152	viral	viral	JJ
cord-269011-230p8rsf	939	153	RNA	RNA	NNP
cord-269011-230p8rsf	939	154	signal	signal	NN
cord-269011-230p8rsf	939	155	Characterization	characterization	NN
cord-269011-230p8rsf	939	156	of	of	IN
cord-269011-230p8rsf	939	157	N	N	NNP
cord-269011-230p8rsf	939	158	protein	protein	NN
cord-269011-230p8rsf	939	159	selfassociation	selfassociation	NN
cord-269011-230p8rsf	939	160	in	in	IN
cord-269011-230p8rsf	939	161	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	162	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	939	163	complexes	complex	NNS
cord-269011-230p8rsf	939	164	Characterization	characterization	NN
cord-269011-230p8rsf	939	165	of	of	IN
cord-269011-230p8rsf	939	166	the	the	DT
cord-269011-230p8rsf	939	167	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	168	M	M	NNP
cord-269011-230p8rsf	939	169	protein	protein	NN
cord-269011-230p8rsf	939	170	and	and	CC
cord-269011-230p8rsf	939	171	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	172	interaction	interaction	NN
cord-269011-230p8rsf	939	173	in	in	IN
cord-269011-230p8rsf	939	174	infected	infected	JJ
cord-269011-230p8rsf	939	175	cells	cell	NNS
cord-269011-230p8rsf	939	176	Cooperation	Cooperation	NNP
cord-269011-230p8rsf	939	177	of	of	IN
cord-269011-230p8rsf	939	178	an	an	DT
cord-269011-230p8rsf	939	179	RNA	RNA	NNP
cord-269011-230p8rsf	939	180	packaging	packaging	NN
cord-269011-230p8rsf	939	181	signal	signal	NN
cord-269011-230p8rsf	939	182	and	and	CC
cord-269011-230p8rsf	939	183	a	a	DT
cord-269011-230p8rsf	939	184	viral	viral	JJ
cord-269011-230p8rsf	939	185	envelope	envelope	NN
cord-269011-230p8rsf	939	186	protein	protein	NN
cord-269011-230p8rsf	939	187	in	in	IN
cord-269011-230p8rsf	939	188	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	189	RNA	RNA	NNP
cord-269011-230p8rsf	939	190	packaging	packaging	NN
cord-269011-230p8rsf	939	191	Localization	Localization	NNP
cord-269011-230p8rsf	939	192	of	of	IN
cord-269011-230p8rsf	939	193	the	the	DT
cord-269011-230p8rsf	939	194	RNA	RNA	NNP
cord-269011-230p8rsf	939	195	-	-	HYPH
cord-269011-230p8rsf	939	196	binding	bind	VBG
cord-269011-230p8rsf	939	197	domain	domain	NN
cord-269011-230p8rsf	939	198	of	of	IN
cord-269011-230p8rsf	939	199	mouse	mouse	NN
cord-269011-230p8rsf	939	200	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	939	201	virus	virus	NN
cord-269011-230p8rsf	939	202	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	939	203	protein	protein	NN
cord-269011-230p8rsf	939	204	High	high	JJ
cord-269011-230p8rsf	939	205	affinity	affinity	NN
cord-269011-230p8rsf	939	206	interaction	interaction	NN
cord-269011-230p8rsf	939	207	between	between	IN
cord-269011-230p8rsf	939	208	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	939	209	protein	protein	NN
cord-269011-230p8rsf	939	210	and	and	CC
cord-269011-230p8rsf	939	211	leader	leader	NN
cord-269011-230p8rsf	939	212	/	/	SYM
cord-269011-230p8rsf	939	213	intergenic	intergenic	JJ
cord-269011-230p8rsf	939	214	sequence	sequence	NN
cord-269011-230p8rsf	939	215	of	of	IN
cord-269011-230p8rsf	939	216	mouse	mouse	NN
cord-269011-230p8rsf	939	217	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	939	218	virus	virus	NN
cord-269011-230p8rsf	939	219	RNA	RNA	NNP
cord-269011-230p8rsf	939	220	Protein	Protein	NNP
cord-269011-230p8rsf	939	221	interactions	interaction	NNS
cord-269011-230p8rsf	939	222	during	during	IN
cord-269011-230p8rsf	939	223	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	224	assembly	assembly	NN
cord-269011-230p8rsf	939	225	Disulfide	Disulfide	NNP
cord-269011-230p8rsf	939	226	bonds	bond	NNS
cord-269011-230p8rsf	939	227	in	in	IN
cord-269011-230p8rsf	939	228	folding	folding	NN
cord-269011-230p8rsf	939	229	and	and	CC
cord-269011-230p8rsf	939	230	transport	transport	NN
cord-269011-230p8rsf	939	231	of	of	IN
cord-269011-230p8rsf	939	232	mouse	mouse	NN
cord-269011-230p8rsf	939	233	hepatitis	hepatitis	NN
cord-269011-230p8rsf	939	234	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	235	glycoproteins	glycoprotein	VBZ
cord-269011-230p8rsf	939	236	Complex	complex	JJ
cord-269011-230p8rsf	939	237	formation	formation	NN
cord-269011-230p8rsf	939	238	between	between	IN
cord-269011-230p8rsf	939	239	the	the	DT
cord-269011-230p8rsf	939	240	spike	spike	NN
cord-269011-230p8rsf	939	241	protein	protein	NN
cord-269011-230p8rsf	939	242	and	and	CC
cord-269011-230p8rsf	939	243	the	the	DT
cord-269011-230p8rsf	939	244	membrane	membrane	NN
cord-269011-230p8rsf	939	245	protein	protein	NN
cord-269011-230p8rsf	939	246	during	during	IN
cord-269011-230p8rsf	939	247	mouse	mouse	NNP
cord-269011-230p8rsf	939	248	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	939	249	virus	virus	NN
cord-269011-230p8rsf	939	250	assembly	assembly	NNP
cord-269011-230p8rsf	939	251	Envelope	Envelope	NNP
cord-269011-230p8rsf	939	252	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	939	253	interactions	interaction	NNS
cord-269011-230p8rsf	939	254	in	in	IN
cord-269011-230p8rsf	939	255	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	256	assembly	assembly	NN
cord-269011-230p8rsf	939	257	Generation	Generation	NNP
cord-269011-230p8rsf	939	258	of	of	IN
cord-269011-230p8rsf	939	259	a	a	DT
cord-269011-230p8rsf	939	260	replicationcompetent	replicationcompetent	NN
cord-269011-230p8rsf	939	261	,	,	,
cord-269011-230p8rsf	939	262	propagation	propagation	NN
cord-269011-230p8rsf	939	263	-	-	HYPH
cord-269011-230p8rsf	939	264	deficient	deficient	JJ
cord-269011-230p8rsf	939	265	virus	virus	NN
cord-269011-230p8rsf	939	266	vector	vector	NN
cord-269011-230p8rsf	939	267	based	base	VBN
cord-269011-230p8rsf	939	268	on	on	IN
cord-269011-230p8rsf	939	269	the	the	DT
cord-269011-230p8rsf	939	270	transmissible	transmissible	JJ
cord-269011-230p8rsf	939	271	gastroenteritis	gastroenteritis	JJ
cord-269011-230p8rsf	939	272	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	273	genome	genome	NN
cord-269011-230p8rsf	939	274	Transmissible	transmissible	JJ
cord-269011-230p8rsf	939	275	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	939	276	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	277	gene	gene	NN
cord-269011-230p8rsf	939	278	7	7	CD
cord-269011-230p8rsf	939	279	is	be	VBZ
cord-269011-230p8rsf	939	280	not	not	RB
cord-269011-230p8rsf	939	281	essential	essential	JJ
cord-269011-230p8rsf	939	282	but	but	CC
cord-269011-230p8rsf	939	283	influences	influence	NNS
cord-269011-230p8rsf	939	284	in	in	IN
cord-269011-230p8rsf	939	285	vivo	vivo	NN
cord-269011-230p8rsf	939	286	virus	virus	NN
cord-269011-230p8rsf	939	287	replication	replication	NN
cord-269011-230p8rsf	939	288	and	and	CC
cord-269011-230p8rsf	939	289	virulence	virulence	NN
cord-269011-230p8rsf	939	290	Electron	Electron	NNP
cord-269011-230p8rsf	939	291	microscopic	microscopic	JJ
cord-269011-230p8rsf	939	292	studies	study	NNS
cord-269011-230p8rsf	939	293	of	of	IN
cord-269011-230p8rsf	939	294	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	295	Cloning	cloning	NN
cord-269011-230p8rsf	939	296	and	and	CC
cord-269011-230p8rsf	939	297	in	in	IN
cord-269011-230p8rsf	939	298	vitro	vitro	FW
cord-269011-230p8rsf	939	299	expression	expression	NN
cord-269011-230p8rsf	939	300	of	of	IN
cord-269011-230p8rsf	939	301	the	the	DT
cord-269011-230p8rsf	939	302	gene	gene	NN
cord-269011-230p8rsf	939	303	for	for	IN
cord-269011-230p8rsf	939	304	the	the	DT
cord-269011-230p8rsf	939	305	E3	E3	NNP
cord-269011-230p8rsf	939	306	haemagglutinin	haemagglutinin	NN
cord-269011-230p8rsf	939	307	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	939	308	of	of	IN
cord-269011-230p8rsf	939	309	bovine	bovine	JJ
cord-269011-230p8rsf	939	310	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	311	Sequence	sequence	NN
cord-269011-230p8rsf	939	312	comparison	comparison	NN
cord-269011-230p8rsf	939	313	of	of	IN
cord-269011-230p8rsf	939	314	the	the	DT
cord-269011-230p8rsf	939	315	N	n	CD
cord-269011-230p8rsf	939	316	genes	gene	NNS
cord-269011-230p8rsf	939	317	of	of	IN
cord-269011-230p8rsf	939	318	five	five	CD
cord-269011-230p8rsf	939	319	strains	strain	NNS
cord-269011-230p8rsf	939	320	of	of	IN
cord-269011-230p8rsf	939	321	the	the	DT
cord-269011-230p8rsf	939	322	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	323	mouse	mouse	NN
cord-269011-230p8rsf	939	324	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	939	325	virus	virus	NN
cord-269011-230p8rsf	939	326	suggests	suggest	VBZ
cord-269011-230p8rsf	939	327	a	a	DT
cord-269011-230p8rsf	939	328	three	three	CD
cord-269011-230p8rsf	939	329	domain	domain	NN
cord-269011-230p8rsf	939	330	structure	structure	NN
cord-269011-230p8rsf	939	331	for	for	IN
cord-269011-230p8rsf	939	332	the	the	DT
cord-269011-230p8rsf	939	333	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	939	334	protein	protein	NN
cord-269011-230p8rsf	939	335	Intracellular	Intracellular	NNP
cord-269011-230p8rsf	939	336	assembly	assembly	NN
cord-269011-230p8rsf	939	337	and	and	CC
cord-269011-230p8rsf	939	338	packaging	packaging	NN
cord-269011-230p8rsf	939	339	of	of	IN
cord-269011-230p8rsf	939	340	hepatitis	hepatitis	NN
cord-269011-230p8rsf	939	341	B	B	NNP
cord-269011-230p8rsf	939	342	surface	surface	NN
cord-269011-230p8rsf	939	343	antigen	antigen	NN
cord-269011-230p8rsf	939	344	particles	particle	NNS
cord-269011-230p8rsf	939	345	occur	occur	VBP
cord-269011-230p8rsf	939	346	in	in	IN
cord-269011-230p8rsf	939	347	the	the	DT
cord-269011-230p8rsf	939	348	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	939	349	reticulum	reticulum	NN
cord-269011-230p8rsf	939	350	Analysis	Analysis	NNP
cord-269011-230p8rsf	939	351	of	of	IN
cord-269011-230p8rsf	939	352	second	second	JJ
cord-269011-230p8rsf	939	353	-	-	HYPH
cord-269011-230p8rsf	939	354	site	site	NN
cord-269011-230p8rsf	939	355	revertants	revertant	NNS
cord-269011-230p8rsf	939	356	of	of	IN
cord-269011-230p8rsf	939	357	a	a	DT
cord-269011-230p8rsf	939	358	murine	murine	JJ
cord-269011-230p8rsf	939	359	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	360	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	361	protein	protein	NN
cord-269011-230p8rsf	939	362	deletion	deletion	NN
cord-269011-230p8rsf	939	363	mutant	mutant	NN
cord-269011-230p8rsf	939	364	and	and	CC
cord-269011-230p8rsf	939	365	construction	construction	NN
cord-269011-230p8rsf	939	366	of	of	IN
cord-269011-230p8rsf	939	367	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	939	368	protein	protein	NN
cord-269011-230p8rsf	939	369	mutants	mutant	NNS
cord-269011-230p8rsf	939	370	by	by	IN
cord-269011-230p8rsf	939	371	targeted	target	VBN
cord-269011-230p8rsf	939	372	RNA	RNA	NNP
cord-269011-230p8rsf	939	373	recombination	recombination	NN
cord-269011-230p8rsf	939	374	Construction	construction	NN
cord-269011-230p8rsf	939	375	of	of	IN
cord-269011-230p8rsf	939	376	murine	murine	JJ
cord-269011-230p8rsf	939	377	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	378	mutants	mutant	NNS
cord-269011-230p8rsf	939	379	containing	contain	VBG
cord-269011-230p8rsf	939	380	interspecies	interspecie	NNS
cord-269011-230p8rsf	939	381	chimeric	chimeric	JJ
cord-269011-230p8rsf	939	382	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	383	proteins	protein	NNS
cord-269011-230p8rsf	939	384	Pathogenesis	Pathogenesis	NNP
cord-269011-230p8rsf	939	385	of	of	IN
cord-269011-230p8rsf	939	386	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	387	-	-	HYPH
cord-269011-230p8rsf	939	388	induced	induce	VBN
cord-269011-230p8rsf	939	389	infections	infection	NNS
cord-269011-230p8rsf	939	390	:	:	:
cord-269011-230p8rsf	939	391	Review	Review	NNP
cord-269011-230p8rsf	939	392	of	of	IN
cord-269011-230p8rsf	939	393	pathological	pathological	JJ
cord-269011-230p8rsf	939	394	and	and	CC
cord-269011-230p8rsf	939	395	immunological	immunological	JJ
cord-269011-230p8rsf	939	396	aspects	aspect	NNS
cord-269011-230p8rsf	939	397	MHV	MHV	NNP
cord-269011-230p8rsf	939	398	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	939	399	synthesis	synthesis	NN
cord-269011-230p8rsf	939	400	in	in	IN
cord-269011-230p8rsf	939	401	the	the	DT
cord-269011-230p8rsf	939	402	presence	presence	NN
cord-269011-230p8rsf	939	403	of	of	IN
cord-269011-230p8rsf	939	404	cycloheximide	cycloheximide	NN
cord-269011-230p8rsf	939	405	and	and	CC
cord-269011-230p8rsf	939	406	accumulation	accumulation	NN
cord-269011-230p8rsf	939	407	of	of	IN
cord-269011-230p8rsf	939	408	negative	negative	JJ
cord-269011-230p8rsf	939	409	strand	strand	NN
cord-269011-230p8rsf	939	410	MHV	MHV	NNP
cord-269011-230p8rsf	939	411	RNA	RNA	NNP
cord-269011-230p8rsf	939	412	High	high	JJ
cord-269011-230p8rsf	939	413	level	level	NN
cord-269011-230p8rsf	939	414	transient	transient	JJ
cord-269011-230p8rsf	939	415	expression	expression	NN
cord-269011-230p8rsf	939	416	of	of	IN
cord-269011-230p8rsf	939	417	the	the	DT
cord-269011-230p8rsf	939	418	murine	murine	JJ
cord-269011-230p8rsf	939	419	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	420	haemagglutinin	haemagglutinin	NN
cord-269011-230p8rsf	939	421	-	-	HYPH
cord-269011-230p8rsf	939	422	esterase	esterase	NN
cord-269011-230p8rsf	939	423	Functional	functional	JJ
cord-269011-230p8rsf	939	424	analysis	analysis	NN
cord-269011-230p8rsf	939	425	of	of	IN
cord-269011-230p8rsf	939	426	the	the	DT
cord-269011-230p8rsf	939	427	coronavirus	coronavirus	NN
cord-269011-230p8rsf	939	428	MHV	MHV	NNP
cord-269011-230p8rsf	939	429	-	-	HYPH
cord-269011-230p8rsf	939	430	JHM	JHM	NNP
cord-269011-230p8rsf	939	431	surface	surface	NN
cord-269011-230p8rsf	939	432	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	939	433	in	in	IN
cord-269011-230p8rsf	939	434	vaccinia	vaccinia	NN
cord-269011-230p8rsf	939	435	virus	virus	NN
cord-269011-230p8rsf	939	436	recombinants	recombinant	NNS
cord-269011-230p8rsf	940	1	The	the	DT
cord-269011-230p8rsf	940	2	polypeptides	polypeptide	NNS
cord-269011-230p8rsf	940	3	of	of	IN
cord-269011-230p8rsf	940	4	haemagglutinating	haemagglutinate	VBG
cord-269011-230p8rsf	940	5	encephalomyelitis	encephalomyelitis	NN
cord-269011-230p8rsf	940	6	virus	virus	NN
cord-269011-230p8rsf	940	7	and	and	CC
cord-269011-230p8rsf	940	8	isolated	isolate	VBN
cord-269011-230p8rsf	940	9	subviral	subviral	JJ
cord-269011-230p8rsf	940	10	particles	particle	NNS
cord-269011-230p8rsf	941	1	The	the	DT
cord-269011-230p8rsf	941	2	spike	spike	NN
cord-269011-230p8rsf	941	3	but	but	CC
cord-269011-230p8rsf	941	4	not	not	RB
cord-269011-230p8rsf	941	5	the	the	DT
cord-269011-230p8rsf	941	6	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	941	7	/	/	SYM
cord-269011-230p8rsf	941	8	esterase	esterase	NN
cord-269011-230p8rsf	941	9	protein	protein	NN
cord-269011-230p8rsf	941	10	of	of	IN
cord-269011-230p8rsf	941	11	bovine	bovine	JJ
cord-269011-230p8rsf	941	12	coronavirus	coronavirus	NN
cord-269011-230p8rsf	941	13	is	be	VBZ
cord-269011-230p8rsf	941	14	necessary	necessary	JJ
cord-269011-230p8rsf	941	15	and	and	CC
cord-269011-230p8rsf	941	16	sufficient	sufficient	JJ
cord-269011-230p8rsf	941	17	for	for	IN
cord-269011-230p8rsf	941	18	viral	viral	JJ
cord-269011-230p8rsf	941	19	infection	infection	NN
cord-269011-230p8rsf	942	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	942	2	replication	replication	NN
cord-269011-230p8rsf	942	3	complex	complex	JJ
cord-269011-230p8rsf	942	4	formation	formation	NN
cord-269011-230p8rsf	942	5	utilizes	utilize	VBZ
cord-269011-230p8rsf	942	6	components	component	NNS
cord-269011-230p8rsf	942	7	of	of	IN
cord-269011-230p8rsf	942	8	cellular	cellular	JJ
cord-269011-230p8rsf	942	9	autophagy	autophagy	NN
cord-269011-230p8rsf	942	10	Characterization	characterization	NN
cord-269011-230p8rsf	942	11	of	of	IN
cord-269011-230p8rsf	942	12	the	the	DT
cord-269011-230p8rsf	942	13	coronavirus	coronavirus	NN
cord-269011-230p8rsf	942	14	mouse	mouse	NN
cord-269011-230p8rsf	942	15	hepatitis	hepatitis	NN
cord-269011-230p8rsf	942	16	virus	virus	NN
cord-269011-230p8rsf	942	17	strain	strain	VBP
cord-269011-230p8rsf	942	18	A59	A59	NNP
cord-269011-230p8rsf	942	19	small	small	JJ
cord-269011-230p8rsf	942	20	membrane	membrane	NN
cord-269011-230p8rsf	942	21	protein	protein	NN
cord-269011-230p8rsf	943	1	E	E	NNP
cord-269011-230p8rsf	943	2	The	the	DT
cord-269011-230p8rsf	944	1	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	944	2	-	-	HYPH
cord-269011-230p8rsf	944	3	esterase	esterase	NN
cord-269011-230p8rsf	944	4	of	of	IN
cord-269011-230p8rsf	944	5	mouse	mouse	NNP
cord-269011-230p8rsf	944	6	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	944	7	virus	virus	NN
cord-269011-230p8rsf	944	8	strain	strain	NN
cord-269011-230p8rsf	944	9	S	S	NNP
cord-269011-230p8rsf	944	10	is	be	VBZ
cord-269011-230p8rsf	944	11	a	a	DT
cord-269011-230p8rsf	944	12	sialate-4-O	sialate-4-o	NN
cord-269011-230p8rsf	944	13	-	-	HYPH
cord-269011-230p8rsf	944	14	acetylesterase	acetylesterase	NNP
cord-269011-230p8rsf	944	15	A	a	DT
cord-269011-230p8rsf	944	16	conditionallethal	conditionallethal	NN
cord-269011-230p8rsf	944	17	murine	murine	JJ
cord-269011-230p8rsf	944	18	coronavirus	coronavirus	NN
cord-269011-230p8rsf	944	19	mutant	mutant	NN
cord-269011-230p8rsf	944	20	that	that	WDT
cord-269011-230p8rsf	944	21	fails	fail	VBZ
cord-269011-230p8rsf	944	22	to	to	TO
cord-269011-230p8rsf	944	23	incorporate	incorporate	VB
cord-269011-230p8rsf	944	24	the	the	DT
cord-269011-230p8rsf	944	25	spike	spike	NN
cord-269011-230p8rsf	944	26	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	944	27	into	into	IN
cord-269011-230p8rsf	944	28	assembled	assemble	VBN
cord-269011-230p8rsf	944	29	virions	virion	NNS
cord-269011-230p8rsf	944	30	Membrane	membrane	NN
cord-269011-230p8rsf	944	31	protein	protein	NN
cord-269011-230p8rsf	944	32	molecules	molecule	NNS
cord-269011-230p8rsf	944	33	of	of	IN
cord-269011-230p8rsf	944	34	transmissible	transmissible	JJ
cord-269011-230p8rsf	944	35	gastroenteritis	gastroenteritis	JJ
cord-269011-230p8rsf	944	36	coronavirus	coronavirus	NN
cord-269011-230p8rsf	944	37	also	also	RB
cord-269011-230p8rsf	944	38	expose	expose	VBP
cord-269011-230p8rsf	944	39	the	the	DT
cord-269011-230p8rsf	944	40	carboxy	carboxy	JJ
cord-269011-230p8rsf	944	41	-	-	HYPH
cord-269011-230p8rsf	944	42	terminal	terminal	NN
cord-269011-230p8rsf	944	43	region	region	NN
cord-269011-230p8rsf	944	44	on	on	IN
cord-269011-230p8rsf	944	45	the	the	DT
cord-269011-230p8rsf	944	46	external	external	JJ
cord-269011-230p8rsf	944	47	surface	surface	NN
cord-269011-230p8rsf	944	48	of	of	IN
cord-269011-230p8rsf	944	49	the	the	DT
cord-269011-230p8rsf	944	50	virion	virion	NN
cord-269011-230p8rsf	945	1	The	the	DT
cord-269011-230p8rsf	945	2	transmissible	transmissible	JJ
cord-269011-230p8rsf	945	3	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	945	4	coronavirus	coronavirus	NN
cord-269011-230p8rsf	945	5	contains	contain	VBZ
cord-269011-230p8rsf	945	6	a	a	DT
cord-269011-230p8rsf	945	7	spherical	spherical	JJ
cord-269011-230p8rsf	945	8	core	core	NN
cord-269011-230p8rsf	945	9	shell	shell	NN
cord-269011-230p8rsf	945	10	consisting	consist	VBG
cord-269011-230p8rsf	945	11	of	of	IN
cord-269011-230p8rsf	945	12	M	M	NNP
cord-269011-230p8rsf	945	13	and	and	CC
cord-269011-230p8rsf	945	14	N	n	CD
cord-269011-230p8rsf	945	15	proteins	protein	NNS
cord-269011-230p8rsf	945	16	Two	two	CD
cord-269011-230p8rsf	945	17	types	type	NNS
cord-269011-230p8rsf	945	18	of	of	IN
cord-269011-230p8rsf	945	19	virusrelated	virusrelate	VBN
cord-269011-230p8rsf	945	20	particles	particle	NNS
cord-269011-230p8rsf	945	21	are	be	VBP
cord-269011-230p8rsf	945	22	found	find	VBN
cord-269011-230p8rsf	945	23	during	during	IN
cord-269011-230p8rsf	945	24	transmissible	transmissible	JJ
cord-269011-230p8rsf	945	25	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	945	26	virus	virus	NN
cord-269011-230p8rsf	945	27	morphogenesis	morphogenesis	NN
cord-269011-230p8rsf	945	28	Pathogenic	pathogenic	JJ
cord-269011-230p8rsf	945	29	murine	murine	JJ
cord-269011-230p8rsf	945	30	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	945	31	.	.	.
cord-269011-230p8rsf	946	1	I.	I.	NNP
cord-269011-230p8rsf	946	2	Characterization	characterization	NN
cord-269011-230p8rsf	946	3	of	of	IN
cord-269011-230p8rsf	946	4	biological	biological	JJ
cord-269011-230p8rsf	946	5	behavior	behavior	NN
cord-269011-230p8rsf	946	6	in	in	IN
cord-269011-230p8rsf	946	7	vitro	vitro	FW
cord-269011-230p8rsf	946	8	and	and	CC
cord-269011-230p8rsf	946	9	virus	virus	NN
cord-269011-230p8rsf	946	10	-	-	HYPH
cord-269011-230p8rsf	946	11	specific	specific	JJ
cord-269011-230p8rsf	946	12	intracellular	intracellular	JJ
cord-269011-230p8rsf	946	13	RNA	rna	NN
cord-269011-230p8rsf	946	14	of	of	IN
cord-269011-230p8rsf	947	1	strongly	strongly	RB
cord-269011-230p8rsf	947	2	neurotropic	neurotropic	NNP
cord-269011-230p8rsf	947	3	JHMV	JHMV	NNP
cord-269011-230p8rsf	947	4	and	and	CC
cord-269011-230p8rsf	947	5	weakly	weakly	RB
cord-269011-230p8rsf	947	6	neurotropic	neurotropic	NNP
cord-269011-230p8rsf	948	1	A59V	A59V	NNP
cord-269011-230p8rsf	948	2	viruses	virus	NNS
cord-269011-230p8rsf	949	1	RNAbinding	rnabinding	NN
cord-269011-230p8rsf	949	2	proteins	protein	NNS
cord-269011-230p8rsf	949	3	of	of	IN
cord-269011-230p8rsf	949	4	coronavirus	coronavirus	NN
cord-269011-230p8rsf	949	5	MHV	mhv	NN
cord-269011-230p8rsf	949	6	:	:	:
cord-269011-230p8rsf	949	7	Detection	detection	NN
cord-269011-230p8rsf	949	8	of	of	IN
cord-269011-230p8rsf	949	9	monomeric	monomeric	JJ
cord-269011-230p8rsf	949	10	and	and	CC
cord-269011-230p8rsf	949	11	multimeric	multimeric	JJ
cord-269011-230p8rsf	949	12	N	n	CD
cord-269011-230p8rsf	949	13	protein	protein	NN
cord-269011-230p8rsf	949	14	with	with	IN
cord-269011-230p8rsf	949	15	an	an	DT
cord-269011-230p8rsf	949	16	RNA	RNA	NNP
cord-269011-230p8rsf	949	17	overlay	overlay	NN
cord-269011-230p8rsf	949	18	-	-	HYPH
cord-269011-230p8rsf	949	19	protein	protein	NN
cord-269011-230p8rsf	949	20	blot	blot	NN
cord-269011-230p8rsf	949	21	assay	assay	NN
cord-269011-230p8rsf	949	22	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	949	23	infection	infection	NN
cord-269011-230p8rsf	949	24	of	of	IN
cord-269011-230p8rsf	949	25	polarized	polarized	JJ
cord-269011-230p8rsf	949	26	epithelial	epithelial	JJ
cord-269011-230p8rsf	949	27	cells	cell	NNS
cord-269011-230p8rsf	950	1	The	the	DT
cord-269011-230p8rsf	950	2	coronavirus	coronavirus	NN
cord-269011-230p8rsf	950	3	membrane	membrane	NN
cord-269011-230p8rsf	950	4	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	950	5	Assembly	Assembly	NNP
cord-269011-230p8rsf	950	6	in	in	IN
cord-269011-230p8rsf	950	7	vitro	vitro	FW
cord-269011-230p8rsf	950	8	of	of	IN
cord-269011-230p8rsf	950	9	a	a	DT
cord-269011-230p8rsf	950	10	spanning	span	VBG
cord-269011-230p8rsf	950	11	membrane	membrane	NN
cord-269011-230p8rsf	950	12	protein	protein	NN
cord-269011-230p8rsf	950	13	of	of	IN
cord-269011-230p8rsf	950	14	the	the	DT
cord-269011-230p8rsf	950	15	endoplasmic	endoplasmic	NN
cord-269011-230p8rsf	950	16	reticulum	reticulum	NN
cord-269011-230p8rsf	950	17	:	:	:
cord-269011-230p8rsf	951	1	The	the	DT
cord-269011-230p8rsf	951	2	E1	e1	NN
cord-269011-230p8rsf	951	3	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	951	4	of	of	IN
cord-269011-230p8rsf	951	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	951	6	mouse	mouse	NN
cord-269011-230p8rsf	951	7	hepatitis	hepatitis	NN
cord-269011-230p8rsf	951	8	virus	virus	NN
cord-269011-230p8rsf	951	9	A59	A59	NNP
cord-269011-230p8rsf	951	10	Viral	Viral	NNP
cord-269011-230p8rsf	951	11	protein	protein	NN
cord-269011-230p8rsf	951	12	synthesis	synthesis	NN
cord-269011-230p8rsf	951	13	in	in	IN
cord-269011-230p8rsf	951	14	mouse	mouse	NNP
cord-269011-230p8rsf	951	15	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	951	16	virus	virus	NN
cord-269011-230p8rsf	951	17	strain	strain	VBP
cord-269011-230p8rsf	951	18	A59-infected	a59-infecte	VBN
cord-269011-230p8rsf	951	19	cells	cell	NNS
cord-269011-230p8rsf	951	20	:	:	:
cord-269011-230p8rsf	952	1	Effect	effect	NN
cord-269011-230p8rsf	952	2	of	of	IN
cord-269011-230p8rsf	952	3	tunicamycin	tunicamycin	NNS
cord-269011-230p8rsf	952	4	Expression	expression	NN
cord-269011-230p8rsf	952	5	of	of	IN
cord-269011-230p8rsf	952	6	MHV	MHV	NNP
cord-269011-230p8rsf	952	7	-	-	HYPH
cord-269011-230p8rsf	952	8	A59	A59	NNP
cord-269011-230p8rsf	952	9	M	M	NNP
cord-269011-230p8rsf	952	10	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	952	11	:	:	:
cord-269011-230p8rsf	953	1	Effects	effect	NNS
cord-269011-230p8rsf	953	2	of	of	IN
cord-269011-230p8rsf	953	3	deletions	deletion	NNS
cord-269011-230p8rsf	953	4	on	on	IN
cord-269011-230p8rsf	953	5	membrane	membrane	NN
cord-269011-230p8rsf	953	6	integration	integration	NN
cord-269011-230p8rsf	953	7	and	and	CC
cord-269011-230p8rsf	953	8	intracellular	intracellular	JJ
cord-269011-230p8rsf	953	9	transport	transport	NN
cord-269011-230p8rsf	953	10	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	953	11	E1	E1	NNP
cord-269011-230p8rsf	953	12	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	953	13	expressed	express	VBN
cord-269011-230p8rsf	953	14	from	from	IN
cord-269011-230p8rsf	953	15	cloned	clone	VBN
cord-269011-230p8rsf	953	16	cDNA	cdna	NN
cord-269011-230p8rsf	953	17	localizes	localize	VBZ
cord-269011-230p8rsf	953	18	in	in	IN
cord-269011-230p8rsf	953	19	the	the	DT
cord-269011-230p8rsf	953	20	Golgi	Golgi	NNP
cord-269011-230p8rsf	953	21	region	region	NN
cord-269011-230p8rsf	953	22	Translation	translation	NN
cord-269011-230p8rsf	953	23	of	of	IN
cord-269011-230p8rsf	953	24	three	three	CD
cord-269011-230p8rsf	953	25	mouse	mouse	NN
cord-269011-230p8rsf	953	26	hepatitis	hepatitis	NN
cord-269011-230p8rsf	953	27	virus	virus	NN
cord-269011-230p8rsf	953	28	strain	strain	VBP
cord-269011-230p8rsf	953	29	A59	A59	NNP
cord-269011-230p8rsf	953	30	subgenomic	subgenomic	JJ
cord-269011-230p8rsf	953	31	RNAs	rna	NNS
cord-269011-230p8rsf	953	32	in	in	IN
cord-269011-230p8rsf	953	33	Xenopus	Xenopus	NNP
cord-269011-230p8rsf	953	34	laevis	laevi	NNS
cord-269011-230p8rsf	953	35	oocytes	oocyte	NNS
cord-269011-230p8rsf	954	1	Predicted	predict	VBN
cord-269011-230p8rsf	954	2	membrane	membrane	NN
cord-269011-230p8rsf	954	3	topology	topology	NN
cord-269011-230p8rsf	954	4	of	of	IN
cord-269011-230p8rsf	954	5	the	the	DT
cord-269011-230p8rsf	954	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	954	7	protein	protein	NN
cord-269011-230p8rsf	954	8	E1	E1	NNP
cord-269011-230p8rsf	954	9	Identification	identification	NN
cord-269011-230p8rsf	954	10	of	of	IN
cord-269011-230p8rsf	954	11	spike	spike	NN
cord-269011-230p8rsf	954	12	protein	protein	NN
cord-269011-230p8rsf	954	13	residues	residue	NNS
cord-269011-230p8rsf	954	14	of	of	IN
cord-269011-230p8rsf	954	15	murine	murine	JJ
cord-269011-230p8rsf	954	16	coronavirus	coronavirus	NN
cord-269011-230p8rsf	954	17	responsible	responsible	JJ
cord-269011-230p8rsf	954	18	for	for	IN
cord-269011-230p8rsf	954	19	receptor	receptor	NN
cord-269011-230p8rsf	954	20	-	-	HYPH
cord-269011-230p8rsf	954	21	binding	bind	VBG
cord-269011-230p8rsf	954	22	activity	activity	NN
cord-269011-230p8rsf	954	23	by	by	IN
cord-269011-230p8rsf	954	24	use	use	NN
cord-269011-230p8rsf	954	25	of	of	IN
cord-269011-230p8rsf	954	26	soluble	soluble	JJ
cord-269011-230p8rsf	954	27	receptorresistant	receptorresistant	JJ
cord-269011-230p8rsf	954	28	mutants	mutant	NNS
cord-269011-230p8rsf	954	29	Structural	structural	JJ
cord-269011-230p8rsf	954	30	maturation	maturation	NN
cord-269011-230p8rsf	954	31	of	of	IN
cord-269011-230p8rsf	954	32	the	the	DT
cord-269011-230p8rsf	954	33	transmissible	transmissible	JJ
cord-269011-230p8rsf	954	34	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	954	35	coronavirus	coronavirus	NN
cord-269011-230p8rsf	955	1	A	a	DT
cord-269011-230p8rsf	955	2	conserved	conserved	JJ
cord-269011-230p8rsf	955	3	tryptophan	tryptophan	NN
cord-269011-230p8rsf	955	4	-	-	HYPH
cord-269011-230p8rsf	955	5	rich	rich	JJ
cord-269011-230p8rsf	955	6	motif	motif	NN
cord-269011-230p8rsf	955	7	in	in	IN
cord-269011-230p8rsf	955	8	the	the	DT
cord-269011-230p8rsf	955	9	membrane	membrane	NN
cord-269011-230p8rsf	955	10	-	-	HYPH
cord-269011-230p8rsf	955	11	proximal	proximal	VBG
cord-269011-230p8rsf	955	12	region	region	NN
cord-269011-230p8rsf	955	13	of	of	IN
cord-269011-230p8rsf	955	14	the	the	DT
cord-269011-230p8rsf	955	15	human	human	JJ
cord-269011-230p8rsf	955	16	immunodeficiency	immunodeficiency	NN
cord-269011-230p8rsf	955	17	virus	virus	NN
cord-269011-230p8rsf	955	18	type	type	NN
cord-269011-230p8rsf	956	1	1	1	LS
cord-269011-230p8rsf	956	2	gp41	gp41	NNP
cord-269011-230p8rsf	956	3	ectodomain	ectodomain	NNP
cord-269011-230p8rsf	956	4	is	be	VBZ
cord-269011-230p8rsf	956	5	important	important	JJ
cord-269011-230p8rsf	956	6	for	for	IN
cord-269011-230p8rsf	956	7	Env	env	NN
cord-269011-230p8rsf	956	8	-	-	HYPH
cord-269011-230p8rsf	956	9	mediated	mediate	VBN
cord-269011-230p8rsf	956	10	fusion	fusion	NN
cord-269011-230p8rsf	956	11	and	and	CC
cord-269011-230p8rsf	956	12	virus	virus	NN
cord-269011-230p8rsf	956	13	infectivity	infectivity	NN
cord-269011-230p8rsf	956	14	A	a	DT
cord-269011-230p8rsf	956	15	new	new	JJ
cord-269011-230p8rsf	956	16	model	model	NN
cord-269011-230p8rsf	956	17	for	for	IN
cord-269011-230p8rsf	956	18	coronavirus	coronavirus	NN
cord-269011-230p8rsf	956	19	transcription	transcription	NN
cord-269011-230p8rsf	957	1	The	the	DT
cord-269011-230p8rsf	957	2	S	S	NNP
cord-269011-230p8rsf	957	3	protein	protein	NN
cord-269011-230p8rsf	957	4	of	of	IN
cord-269011-230p8rsf	957	5	bovine	bovine	JJ
cord-269011-230p8rsf	957	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	957	7	is	be	VBZ
cord-269011-230p8rsf	957	8	a	a	DT
cord-269011-230p8rsf	957	9	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	957	10	recognizing	recognize	VBG
cord-269011-230p8rsf	957	11	9-O	9-o	CD
cord-269011-230p8rsf	957	12	-	-	HYPH
cord-269011-230p8rsf	957	13	acetylated	acetylated	JJ
cord-269011-230p8rsf	957	14	sialic	sialic	NN
cord-269011-230p8rsf	957	15	acid	acid	NN
cord-269011-230p8rsf	957	16	as	as	IN
cord-269011-230p8rsf	957	17	a	a	DT
cord-269011-230p8rsf	957	18	receptor	receptor	NN
cord-269011-230p8rsf	957	19	determinant	determinant	NN
cord-269011-230p8rsf	957	20	Bovine	bovine	JJ
cord-269011-230p8rsf	957	21	coronavirus	coronavirus	NN
cord-269011-230p8rsf	957	22	uses	use	VBZ
cord-269011-230p8rsf	957	23	N	n	CD
cord-269011-230p8rsf	957	24	-	-	HYPH
cord-269011-230p8rsf	957	25	acetyl-9-O	acetyl-9-o	NN
cord-269011-230p8rsf	957	26	-	-	HYPH
cord-269011-230p8rsf	957	27	acetylneuraminic	acetylneuraminic	JJ
cord-269011-230p8rsf	957	28	acid	acid	NN
cord-269011-230p8rsf	957	29	as	as	IN
cord-269011-230p8rsf	957	30	a	a	DT
cord-269011-230p8rsf	957	31	receptor	receptor	NN
cord-269011-230p8rsf	957	32	determinant	determinant	NN
cord-269011-230p8rsf	957	33	to	to	TO
cord-269011-230p8rsf	957	34	initiate	initiate	VB
cord-269011-230p8rsf	957	35	the	the	DT
cord-269011-230p8rsf	957	36	infection	infection	NN
cord-269011-230p8rsf	957	37	of	of	IN
cord-269011-230p8rsf	957	38	cultured	cultured	JJ
cord-269011-230p8rsf	957	39	cells	cell	NNS
cord-269011-230p8rsf	957	40	Isolated	isolate	VBN
cord-269011-230p8rsf	957	41	HE	HE	NNP
cord-269011-230p8rsf	957	42	-	-	HYPH
cord-269011-230p8rsf	957	43	protein	protein	NN
cord-269011-230p8rsf	957	44	from	from	IN
cord-269011-230p8rsf	957	45	hemagglutinating	hemagglutinate	VBG
cord-269011-230p8rsf	957	46	encephalomyelitis	encephalomyelitis	NN
cord-269011-230p8rsf	957	47	virus	virus	NN
cord-269011-230p8rsf	957	48	and	and	CC
cord-269011-230p8rsf	957	49	bovine	bovine	JJ
cord-269011-230p8rsf	957	50	coronavirus	coronavirus	NN
cord-269011-230p8rsf	957	51	has	have	VBZ
cord-269011-230p8rsf	957	52	receptordestroying	receptordestroye	VBG
cord-269011-230p8rsf	957	53	and	and	CC
cord-269011-230p8rsf	957	54	receptor	receptor	NN
cord-269011-230p8rsf	957	55	-	-	HYPH
cord-269011-230p8rsf	957	56	binding	bind	VBG
cord-269011-230p8rsf	957	57	activity	activity	NN
cord-269011-230p8rsf	958	1	The	the	DT
cord-269011-230p8rsf	958	2	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	958	3	protein	protein	NN
cord-269011-230p8rsf	958	4	gene	gene	NN
cord-269011-230p8rsf	958	5	of	of	IN
cord-269011-230p8rsf	958	6	bovine	bovine	JJ
cord-269011-230p8rsf	958	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	958	8	is	be	VBZ
cord-269011-230p8rsf	958	9	bicistronic	bicistronic	JJ
cord-269011-230p8rsf	958	10	Minus	minus	NN
cord-269011-230p8rsf	958	11	-	-	HYPH
cord-269011-230p8rsf	958	12	strand	strand	NN
cord-269011-230p8rsf	958	13	copies	copy	NNS
cord-269011-230p8rsf	958	14	of	of	IN
cord-269011-230p8rsf	958	15	replicating	replicate	VBG
cord-269011-230p8rsf	958	16	coronavirus	coronavirus	NN
cord-269011-230p8rsf	958	17	mRNAs	mrnas	TO
cord-269011-230p8rsf	958	18	contain	contain	VBP
cord-269011-230p8rsf	958	19	antileaders	antileader	NNS
cord-269011-230p8rsf	958	20	Emergence	Emergence	NNP
cord-269011-230p8rsf	958	21	of	of	IN
cord-269011-230p8rsf	958	22	a	a	DT
cord-269011-230p8rsf	958	23	coronavirus	coronavirus	NN
cord-269011-230p8rsf	958	24	infectious	infectious	JJ
cord-269011-230p8rsf	958	25	bronchitis	bronchitis	NN
cord-269011-230p8rsf	958	26	virus	virus	NN
cord-269011-230p8rsf	958	27	mutant	mutant	JJ
cord-269011-230p8rsf	958	28	with	with	IN
cord-269011-230p8rsf	958	29	a	a	DT
cord-269011-230p8rsf	958	30	truncated	truncated	JJ
cord-269011-230p8rsf	958	31	3b	3b	CD
cord-269011-230p8rsf	958	32	gene	gene	NN
cord-269011-230p8rsf	958	33	:	:	:
cord-269011-230p8rsf	958	34	Functional	functional	JJ
cord-269011-230p8rsf	958	35	characterization	characterization	NN
cord-269011-230p8rsf	958	36	of	of	IN
cord-269011-230p8rsf	958	37	the	the	DT
cord-269011-230p8rsf	958	38	3b	3b	NNP
cord-269011-230p8rsf	958	39	protein	protein	NN
cord-269011-230p8rsf	958	40	in	in	IN
cord-269011-230p8rsf	958	41	pathogenesis	pathogenesis	NN
cord-269011-230p8rsf	958	42	and	and	CC
cord-269011-230p8rsf	958	43	replication	replication	NN
cord-269011-230p8rsf	958	44	Heterogeneous	heterogeneous	JJ
cord-269011-230p8rsf	958	45	nuclear	nuclear	JJ
cord-269011-230p8rsf	958	46	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	958	47	A1	A1	NNP
cord-269011-230p8rsf	958	48	regulates	regulate	VBZ
cord-269011-230p8rsf	958	49	RNA	RNA	NNP
cord-269011-230p8rsf	958	50	synthesis	synthesis	NN
cord-269011-230p8rsf	958	51	of	of	IN
cord-269011-230p8rsf	958	52	a	a	DT
cord-269011-230p8rsf	958	53	cytoplasmic	cytoplasmic	JJ
cord-269011-230p8rsf	958	54	virus	virus	NN
cord-269011-230p8rsf	959	1	The	the	DT
cord-269011-230p8rsf	959	2	Coronaviridae	Coronaviridae	NNP
cord-269011-230p8rsf	959	3	Characterization	characterization	NN
cord-269011-230p8rsf	959	4	of	of	IN
cord-269011-230p8rsf	959	5	severe	severe	JJ
cord-269011-230p8rsf	959	6	acute	acute	JJ
cord-269011-230p8rsf	959	7	respiratory	respiratory	JJ
cord-269011-230p8rsf	959	8	syndrome	syndrome	NN
cord-269011-230p8rsf	959	9	-	-	HYPH
cord-269011-230p8rsf	959	10	associated	associate	VBN
cord-269011-230p8rsf	959	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	959	12	(	(	-LRB-
cord-269011-230p8rsf	959	13	SARS	SARS	NNP
cord-269011-230p8rsf	959	14	-	-	HYPH
cord-269011-230p8rsf	959	15	CoV	CoV	NNP
cord-269011-230p8rsf	959	16	)	)	-RRB-
cord-269011-230p8rsf	959	17	spike	spike	NN
cord-269011-230p8rsf	959	18	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	959	19	-	-	HYPH
cord-269011-230p8rsf	959	20	mediated	mediate	VBN
cord-269011-230p8rsf	959	21	viral	viral	JJ
cord-269011-230p8rsf	959	22	entry	entry	NN
cord-269011-230p8rsf	959	23	Secreted	secrete	VBN
cord-269011-230p8rsf	959	24	hepatitis	hepatitis	NN
cord-269011-230p8rsf	959	25	B	B	NNP
cord-269011-230p8rsf	959	26	surface	surface	NN
cord-269011-230p8rsf	959	27	antigen	antigen	NN
cord-269011-230p8rsf	959	28	polypeptides	polypeptide	NNS
cord-269011-230p8rsf	959	29	are	be	VBP
cord-269011-230p8rsf	959	30	derived	derive	VBN
cord-269011-230p8rsf	959	31	from	from	IN
cord-269011-230p8rsf	959	32	a	a	DT
cord-269011-230p8rsf	959	33	transmembrane	transmembrane	NN
cord-269011-230p8rsf	959	34	precursor	precursor	NN
cord-269011-230p8rsf	959	35	Mouse	Mouse	NNP
cord-269011-230p8rsf	959	36	hepatitis	hepatitis	NN
cord-269011-230p8rsf	959	37	virus	virus	NN
cord-269011-230p8rsf	959	38	replicase	replicase	NN
cord-269011-230p8rsf	959	39	proteins	protein	NNS
cord-269011-230p8rsf	959	40	associate	associate	VBP
cord-269011-230p8rsf	959	41	with	with	IN
cord-269011-230p8rsf	959	42	two	two	CD
cord-269011-230p8rsf	959	43	distinct	distinct	JJ
cord-269011-230p8rsf	959	44	populations	population	NNS
cord-269011-230p8rsf	959	45	of	of	IN
cord-269011-230p8rsf	959	46	intracellular	intracellular	JJ
cord-269011-230p8rsf	959	47	membranes	membrane	NNS
cord-269011-230p8rsf	959	48	Identification	identification	NN
cord-269011-230p8rsf	959	49	of	of	IN
cord-269011-230p8rsf	959	50	a	a	DT
cord-269011-230p8rsf	959	51	new	new	JJ
cord-269011-230p8rsf	959	52	membrane	membrane	NN
cord-269011-230p8rsf	959	53	-	-	HYPH
cord-269011-230p8rsf	959	54	associated	associate	VBN
cord-269011-230p8rsf	959	55	polypeptide	polypeptide	NN
cord-269011-230p8rsf	959	56	specified	specify	VBN
cord-269011-230p8rsf	959	57	by	by	IN
cord-269011-230p8rsf	959	58	the	the	DT
cord-269011-230p8rsf	959	59	coronavirus	coronavirus	NN
cord-269011-230p8rsf	959	60	infectious	infectious	JJ
cord-269011-230p8rsf	959	61	bronchitis	bronchitis	NN
cord-269011-230p8rsf	959	62	virus	virus	NN
cord-269011-230p8rsf	959	63	Expression	expression	NN
cord-269011-230p8rsf	959	64	of	of	IN
cord-269011-230p8rsf	959	65	transcriptional	transcriptional	JJ
cord-269011-230p8rsf	959	66	units	unit	NNS
cord-269011-230p8rsf	959	67	using	use	VBG
cord-269011-230p8rsf	959	68	transmissible	transmissible	JJ
cord-269011-230p8rsf	959	69	gastroenteritis	gastroenteritis	JJ
cord-269011-230p8rsf	959	70	coronavirus	coronavirus	NN
cord-269011-230p8rsf	959	71	derived	derive	VBN
cord-269011-230p8rsf	959	72	minigenomes	minigenome	NNS
cord-269011-230p8rsf	959	73	and	and	CC
cord-269011-230p8rsf	959	74	full	full	JJ
cord-269011-230p8rsf	959	75	-	-	HYPH
cord-269011-230p8rsf	959	76	length	length	NN
cord-269011-230p8rsf	959	77	cDNA	cdna	NN
cord-269011-230p8rsf	959	78	clones	clone	NNS
cord-269011-230p8rsf	959	79	Isolation	isolation	NN
cord-269011-230p8rsf	959	80	and	and	CC
cord-269011-230p8rsf	959	81	identification	identification	NN
cord-269011-230p8rsf	959	82	of	of	IN
cord-269011-230p8rsf	959	83	virus	virus	NN
cord-269011-230p8rsf	959	84	-	-	HYPH
cord-269011-230p8rsf	959	85	specific	specific	JJ
cord-269011-230p8rsf	959	86	mRNAs	mRNAs	NNPS
cord-269011-230p8rsf	959	87	in	in	IN
cord-269011-230p8rsf	959	88	cells	cell	NNS
cord-269011-230p8rsf	959	89	infected	infect	VBN
cord-269011-230p8rsf	959	90	with	with	IN
cord-269011-230p8rsf	959	91	mouse	mouse	NN
cord-269011-230p8rsf	959	92	hepatitis	hepatitis	NN
cord-269011-230p8rsf	959	93	virus	virus	NN
cord-269011-230p8rsf	959	94	(	(	-LRB-
cord-269011-230p8rsf	959	95	MHV	MHV	NNP
cord-269011-230p8rsf	959	96	-	-	HYPH
cord-269011-230p8rsf	959	97	A59	A59	NNP
cord-269011-230p8rsf	959	98	)	)	-RRB-
cord-269011-230p8rsf	960	1	Coronavirus	Coronavirus	NNP
cord-269011-230p8rsf	960	2	proteins	protein	NNS
cord-269011-230p8rsf	960	3	:	:	:
cord-269011-230p8rsf	960	4	Structure	structure	NN
cord-269011-230p8rsf	960	5	and	and	CC
cord-269011-230p8rsf	960	6	function	function	NN
cord-269011-230p8rsf	960	7	of	of	IN
cord-269011-230p8rsf	960	8	the	the	DT
cord-269011-230p8rsf	960	9	oligosaccharides	oligosaccharide	NNS
cord-269011-230p8rsf	960	10	of	of	IN
cord-269011-230p8rsf	960	11	the	the	DT
cord-269011-230p8rsf	960	12	avian	avian	JJ
cord-269011-230p8rsf	960	13	infectious	infectious	JJ
cord-269011-230p8rsf	960	14	bronchitis	bronchitis	NN
cord-269011-230p8rsf	960	15	virus	virus	NN
cord-269011-230p8rsf	960	16	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	960	17	Specific	specific	JJ
cord-269011-230p8rsf	960	18	interaction	interaction	NN
cord-269011-230p8rsf	960	19	between	between	IN
cord-269011-230p8rsf	960	20	coronavirus	coronavirus	NN
cord-269011-230p8rsf	960	21	leader	leader	NN
cord-269011-230p8rsf	960	22	RNA	RNA	NNP
cord-269011-230p8rsf	960	23	and	and	CC
cord-269011-230p8rsf	960	24	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	960	25	protein	protein	NN
cord-269011-230p8rsf	960	26	Synthesis	Synthesis	NNP
cord-269011-230p8rsf	960	27	and	and	CC
cord-269011-230p8rsf	960	28	subcellular	subcellular	JJ
cord-269011-230p8rsf	960	29	localization	localization	NN
cord-269011-230p8rsf	960	30	of	of	IN
cord-269011-230p8rsf	960	31	the	the	DT
cord-269011-230p8rsf	960	32	murine	murine	JJ
cord-269011-230p8rsf	960	33	coronavirus	coronavirus	NN
cord-269011-230p8rsf	960	34	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	960	35	protein	protein	NN
cord-269011-230p8rsf	960	36	Mouse	Mouse	NNP
cord-269011-230p8rsf	960	37	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	960	38	virus	virus	NN
cord-269011-230p8rsf	960	39	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	960	40	protein	protein	NN
cord-269011-230p8rsf	960	41	-	-	HYPH
cord-269011-230p8rsf	960	42	specific	specific	JJ
cord-269011-230p8rsf	960	43	cytotoxic	cytotoxic	JJ
cord-269011-230p8rsf	960	44	T	t	NN
cord-269011-230p8rsf	960	45	lymphocytes	lymphocyte	NNS
cord-269011-230p8rsf	960	46	are	be	VBP
cord-269011-230p8rsf	960	47	Ld	Ld	NNP
cord-269011-230p8rsf	960	48	restricted	restrict	VBN
cord-269011-230p8rsf	960	49	and	and	CC
cord-269011-230p8rsf	960	50	specific	specific	JJ
cord-269011-230p8rsf	960	51	for	for	IN
cord-269011-230p8rsf	960	52	the	the	DT
cord-269011-230p8rsf	960	53	carboxy	carboxy	JJ
cord-269011-230p8rsf	960	54	terminus	terminus	NN
cord-269011-230p8rsf	960	55	Phosphoproteins	Phosphoproteins	NNP
cord-269011-230p8rsf	960	56	of	of	IN
cord-269011-230p8rsf	960	57	murine	murine	JJ
cord-269011-230p8rsf	960	58	hepatitis	hepatitis	NN
cord-269011-230p8rsf	960	59	viruses	virus	NNS
cord-269011-230p8rsf	961	1	Isolation	isolation	NN
cord-269011-230p8rsf	961	2	of	of	IN
cord-269011-230p8rsf	961	3	coronavirus	coronavirus	NN
cord-269011-230p8rsf	961	4	envelope	envelope	NN
cord-269011-230p8rsf	961	5	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	961	6	and	and	CC
cord-269011-230p8rsf	961	7	interaction	interaction	NN
cord-269011-230p8rsf	961	8	with	with	IN
cord-269011-230p8rsf	961	9	the	the	DT
cord-269011-230p8rsf	961	10	viral	viral	JJ
cord-269011-230p8rsf	961	11	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	961	12	Conformational	Conformational	NNP
cord-269011-230p8rsf	961	13	change	change	NN
cord-269011-230p8rsf	961	14	of	of	IN
cord-269011-230p8rsf	961	15	the	the	DT
cord-269011-230p8rsf	961	16	coronavirus	coronavirus	NN
cord-269011-230p8rsf	961	17	peplomer	peplomer	NN
cord-269011-230p8rsf	961	18	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	961	19	at	at	IN
cord-269011-230p8rsf	961	20	pH	pH	NNP
cord-269011-230p8rsf	961	21	8.0	8.0	CD
cord-269011-230p8rsf	961	22	and	and	CC
cord-269011-230p8rsf	961	23	37	37	CD
cord-269011-230p8rsf	961	24	C	c	NN
cord-269011-230p8rsf	961	25	correlates	correlate	VBZ
cord-269011-230p8rsf	961	26	with	with	IN
cord-269011-230p8rsf	961	27	virus	virus	NN
cord-269011-230p8rsf	961	28	aggregation	aggregation	NN
cord-269011-230p8rsf	961	29	and	and	CC
cord-269011-230p8rsf	961	30	virus	virus	NN
cord-269011-230p8rsf	961	31	-	-	HYPH
cord-269011-230p8rsf	961	32	induced	induce	VBN
cord-269011-230p8rsf	961	33	cell	cell	NN
cord-269011-230p8rsf	961	34	fusion	fusion	NN
cord-269011-230p8rsf	961	35	Morphological	morphological	JJ
cord-269011-230p8rsf	961	36	and	and	CC
cord-269011-230p8rsf	961	37	biological	biological	JJ
cord-269011-230p8rsf	961	38	properties	property	NNS
cord-269011-230p8rsf	961	39	of	of	IN
cord-269011-230p8rsf	961	40	a	a	DT
cord-269011-230p8rsf	961	41	new	new	JJ
cord-269011-230p8rsf	961	42	coronavirus	coronavirus	NN
cord-269011-230p8rsf	961	43	associated	associate	VBN
cord-269011-230p8rsf	961	44	with	with	IN
cord-269011-230p8rsf	961	45	diarrhea	diarrhea	NN
cord-269011-230p8rsf	961	46	in	in	IN
cord-269011-230p8rsf	961	47	infant	infant	NN
cord-269011-230p8rsf	961	48	mice	mouse	NNS
cord-269011-230p8rsf	962	1	Potent	potent	JJ
cord-269011-230p8rsf	962	2	neutralization	neutralization	NN
cord-269011-230p8rsf	962	3	of	of	IN
cord-269011-230p8rsf	962	4	severe	severe	JJ
cord-269011-230p8rsf	962	5	acute	acute	JJ
cord-269011-230p8rsf	962	6	respiratory	respiratory	JJ
cord-269011-230p8rsf	962	7	syndrome	syndrome	NN
cord-269011-230p8rsf	962	8	(	(	-LRB-
cord-269011-230p8rsf	962	9	SARS	SARS	NNP
cord-269011-230p8rsf	962	10	)	)	-RRB-
cord-269011-230p8rsf	962	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	962	12	by	by	IN
cord-269011-230p8rsf	962	13	a	a	DT
cord-269011-230p8rsf	962	14	human	human	JJ
cord-269011-230p8rsf	962	15	mAb	mab	NN
cord-269011-230p8rsf	962	16	to	to	IN
cord-269011-230p8rsf	962	17	S1	s1	NN
cord-269011-230p8rsf	962	18	protein	protein	NN
cord-269011-230p8rsf	962	19	that	that	WDT
cord-269011-230p8rsf	962	20	blocks	block	VBZ
cord-269011-230p8rsf	962	21	receptor	receptor	NNP
cord-269011-230p8rsf	962	22	association	association	NNP
cord-269011-230p8rsf	963	1	The	the	DT
cord-269011-230p8rsf	963	2	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	963	3	protein	protein	NN
cord-269011-230p8rsf	963	4	of	of	IN
cord-269011-230p8rsf	963	5	the	the	DT
cord-269011-230p8rsf	963	6	SARS	SARS	NNP
cord-269011-230p8rsf	963	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	8	is	be	VBZ
cord-269011-230p8rsf	963	9	capable	capable	JJ
cord-269011-230p8rsf	963	10	of	of	IN
cord-269011-230p8rsf	963	11	self	self	NN
cord-269011-230p8rsf	963	12	-	-	HYPH
cord-269011-230p8rsf	963	13	association	association	NN
cord-269011-230p8rsf	963	14	through	through	IN
cord-269011-230p8rsf	963	15	a	a	DT
cord-269011-230p8rsf	963	16	Cterminal	Cterminal	NNP
cord-269011-230p8rsf	963	17	209	209	CD
cord-269011-230p8rsf	963	18	amino	amino	NN
cord-269011-230p8rsf	963	19	acid	acid	NN
cord-269011-230p8rsf	963	20	interaction	interaction	NN
cord-269011-230p8rsf	963	21	domain	domain	NN
cord-269011-230p8rsf	963	22	Analysis	analysis	NN
cord-269011-230p8rsf	963	23	of	of	IN
cord-269011-230p8rsf	963	24	the	the	DT
cord-269011-230p8rsf	963	25	receptor	receptor	NN
cord-269011-230p8rsf	963	26	-	-	HYPH
cord-269011-230p8rsf	963	27	binding	bind	VBG
cord-269011-230p8rsf	963	28	site	site	NN
cord-269011-230p8rsf	963	29	of	of	IN
cord-269011-230p8rsf	963	30	murine	murine	JJ
cord-269011-230p8rsf	963	31	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	32	spike	spike	NN
cord-269011-230p8rsf	963	33	protein	protein	NN
cord-269011-230p8rsf	963	34	A	a	DT
cord-269011-230p8rsf	963	35	Golgi	Golgi	NNP
cord-269011-230p8rsf	963	36	retention	retention	NN
cord-269011-230p8rsf	963	37	signal	signal	NN
cord-269011-230p8rsf	963	38	in	in	IN
cord-269011-230p8rsf	963	39	a	a	DT
cord-269011-230p8rsf	963	40	membranespanning	membranespanne	VBG
cord-269011-230p8rsf	963	41	domain	domain	NN
cord-269011-230p8rsf	963	42	of	of	IN
cord-269011-230p8rsf	963	43	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	44	E1	e1	NN
cord-269011-230p8rsf	963	45	protein	protein	NN
cord-269011-230p8rsf	963	46	Soluble	soluble	JJ
cord-269011-230p8rsf	963	47	receptor	receptor	NN
cord-269011-230p8rsf	963	48	potentiates	potentiate	VBZ
cord-269011-230p8rsf	963	49	receptorindependent	receptorindependent	NN
cord-269011-230p8rsf	963	50	infection	infection	NN
cord-269011-230p8rsf	963	51	by	by	IN
cord-269011-230p8rsf	963	52	murine	murine	JJ
cord-269011-230p8rsf	963	53	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	54	Mouse	Mouse	NNP
cord-269011-230p8rsf	963	55	hepatitis	hepatitis	NN
cord-269011-230p8rsf	963	56	virus	virus	NN
cord-269011-230p8rsf	963	57	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	963	58	protein	protein	NN
cord-269011-230p8rsf	963	59	as	as	IN
cord-269011-230p8rsf	963	60	a	a	DT
cord-269011-230p8rsf	963	61	translational	translational	JJ
cord-269011-230p8rsf	963	62	effector	effector	NN
cord-269011-230p8rsf	963	63	of	of	IN
cord-269011-230p8rsf	963	64	viral	viral	JJ
cord-269011-230p8rsf	963	65	mRNAs	mrnas	CD
cord-269011-230p8rsf	963	66	Multigene	Multigene	NNP
cord-269011-230p8rsf	963	67	RNA	RNA	NNP
cord-269011-230p8rsf	963	68	vector	vector	NN
cord-269011-230p8rsf	963	69	based	base	VBN
cord-269011-230p8rsf	963	70	on	on	IN
cord-269011-230p8rsf	963	71	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	72	transcription	transcription	NN
cord-269011-230p8rsf	963	73	Replication	replication	NN
cord-269011-230p8rsf	963	74	of	of	IN
cord-269011-230p8rsf	963	75	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	76	MHV	mhv	NN
cord-269011-230p8rsf	963	77	-	-	HYPH
cord-269011-230p8rsf	963	78	A59	A59	NNP
cord-269011-230p8rsf	963	79	in	in	IN
cord-269011-230p8rsf	963	80	saccells	saccell	NNS
cord-269011-230p8rsf	963	81	:	:	:
cord-269011-230p8rsf	963	82	Determination	determination	NN
cord-269011-230p8rsf	963	83	of	of	IN
cord-269011-230p8rsf	963	84	the	the	DT
cord-269011-230p8rsf	963	85	first	first	JJ
cord-269011-230p8rsf	963	86	site	site	NN
cord-269011-230p8rsf	963	87	of	of	IN
cord-269011-230p8rsf	963	88	budding	budding	NN
cord-269011-230p8rsf	963	89	of	of	IN
cord-269011-230p8rsf	963	90	progeny	progeny	JJ
cord-269011-230p8rsf	963	91	virions	virion	NNS
cord-269011-230p8rsf	963	92	Sorting	sort	VBG
cord-269011-230p8rsf	963	93	of	of	IN
cord-269011-230p8rsf	963	94	progeny	progeny	JJ
cord-269011-230p8rsf	963	95	coronavirus	coronavirus	NN
cord-269011-230p8rsf	963	96	from	from	IN
cord-269011-230p8rsf	963	97	condensed	condense	VBN
cord-269011-230p8rsf	963	98	secretory	secretory	JJ
cord-269011-230p8rsf	963	99	proteins	protein	NNS
cord-269011-230p8rsf	963	100	at	at	IN
cord-269011-230p8rsf	963	101	the	the	DT
cord-269011-230p8rsf	963	102	exit	exit	NN
cord-269011-230p8rsf	963	103	from	from	IN
cord-269011-230p8rsf	963	104	the	the	DT
cord-269011-230p8rsf	963	105	trans	trans	NNP
cord-269011-230p8rsf	963	106	-	-	NNP
cord-269011-230p8rsf	963	107	Golgi	Golgi	NNP
cord-269011-230p8rsf	963	108	network	network	NN
cord-269011-230p8rsf	963	109	of	of	IN
cord-269011-230p8rsf	963	110	AtT20	AtT20	NNP
cord-269011-230p8rsf	963	111	cells	cell	VBZ
cord-269011-230p8rsf	963	112	Feline	feline	JJ
cord-269011-230p8rsf	963	113	aminopeptidase	aminopeptidase	NN
cord-269011-230p8rsf	963	114	N	n	CD
cord-269011-230p8rsf	963	115	serves	serve	VBZ
cord-269011-230p8rsf	963	116	as	as	IN
cord-269011-230p8rsf	963	117	a	a	DT
cord-269011-230p8rsf	963	118	receptor	receptor	NN
cord-269011-230p8rsf	963	119	for	for	IN
cord-269011-230p8rsf	963	120	feline	feline	JJ
cord-269011-230p8rsf	963	121	,	,	,
cord-269011-230p8rsf	963	122	canine	canine	JJ
cord-269011-230p8rsf	963	123	,	,	,
cord-269011-230p8rsf	963	124	porcine	porcine	JJ
cord-269011-230p8rsf	963	125	,	,	,
cord-269011-230p8rsf	963	126	and	and	CC
cord-269011-230p8rsf	963	127	human	human	JJ
cord-269011-230p8rsf	963	128	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	963	129	in	in	IN
cord-269011-230p8rsf	963	130	serogroup	serogroup	NNP
cord-269011-230p8rsf	964	1	I	-PRON-	PRP
cord-269011-230p8rsf	965	1	Structural	structural	JJ
cord-269011-230p8rsf	965	2	characterization	characterization	NN
cord-269011-230p8rsf	965	3	of	of	IN
cord-269011-230p8rsf	965	4	the	the	DT
cord-269011-230p8rsf	965	5	SARS	SARS	NNP
cord-269011-230p8rsf	965	6	-	-	HYPH
cord-269011-230p8rsf	965	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	965	8	spike	spike	NN
cord-269011-230p8rsf	965	9	S	s	NN
cord-269011-230p8rsf	965	10	fusion	fusion	NN
cord-269011-230p8rsf	965	11	protein	protein	NN
cord-269011-230p8rsf	965	12	core	core	NN
cord-269011-230p8rsf	966	1	The	the	DT
cord-269011-230p8rsf	966	2	N	n	CD
cord-269011-230p8rsf	966	3	-	-	HYPH
cord-269011-230p8rsf	966	4	terminal	terminal	NN
cord-269011-230p8rsf	966	5	domain	domain	NN
cord-269011-230p8rsf	966	6	of	of	IN
cord-269011-230p8rsf	966	7	the	the	DT
cord-269011-230p8rsf	966	8	murine	murine	JJ
cord-269011-230p8rsf	966	9	coronavirus	coronavirus	NN
cord-269011-230p8rsf	966	10	spike	spike	NN
cord-269011-230p8rsf	966	11	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	966	12	determines	determine	VBZ
cord-269011-230p8rsf	966	13	the	the	DT
cord-269011-230p8rsf	966	14	CEACAM1	CEACAM1	NNP
cord-269011-230p8rsf	966	15	receptor	receptor	NN
cord-269011-230p8rsf	966	16	specificity	specificity	NN
cord-269011-230p8rsf	966	17	of	of	IN
cord-269011-230p8rsf	966	18	the	the	DT
cord-269011-230p8rsf	966	19	virus	virus	NN
cord-269011-230p8rsf	966	20	strain	strain	NN
cord-269011-230p8rsf	966	21	The	the	DT
cord-269011-230p8rsf	966	22	9-kDa	9-kda	CD
cord-269011-230p8rsf	966	23	hydrophobic	hydrophobic	JJ
cord-269011-230p8rsf	966	24	protein	protein	NN
cord-269011-230p8rsf	966	25	encoded	encode	VBN
cord-269011-230p8rsf	966	26	at	at	IN
cord-269011-230p8rsf	966	27	the	the	DT
cord-269011-230p8rsf	966	28	3	3	CD
cord-269011-230p8rsf	966	29	0	0	CD
cord-269011-230p8rsf	966	30	end	end	NN
cord-269011-230p8rsf	966	31	of	of	IN
cord-269011-230p8rsf	966	32	the	the	DT
cord-269011-230p8rsf	966	33	porcine	porcine	JJ
cord-269011-230p8rsf	966	34	transmissible	transmissible	JJ
cord-269011-230p8rsf	966	35	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	966	36	coronavirus	coronavirus	NN
cord-269011-230p8rsf	966	37	genome	genome	NN
cord-269011-230p8rsf	967	1	is	be	VBZ
cord-269011-230p8rsf	967	2	membrane	membrane	NN
cord-269011-230p8rsf	967	3	-	-	HYPH
cord-269011-230p8rsf	967	4	associated	associate	VBN
cord-269011-230p8rsf	967	5	Fatty	fatty	JJ
cord-269011-230p8rsf	967	6	acid	acid	NN
cord-269011-230p8rsf	967	7	acylation	acylation	NN
cord-269011-230p8rsf	967	8	of	of	IN
cord-269011-230p8rsf	967	9	viral	viral	JJ
cord-269011-230p8rsf	967	10	proteins	protein	NNS
cord-269011-230p8rsf	967	11	in	in	IN
cord-269011-230p8rsf	967	12	murine	murine	JJ
cord-269011-230p8rsf	967	13	hepatitis	hepatitis	NN
cord-269011-230p8rsf	967	14	virus	virus	NN
cord-269011-230p8rsf	967	15	-	-	HYPH
cord-269011-230p8rsf	967	16	infected	infect	VBN
cord-269011-230p8rsf	967	17	cells	cell	NNS
cord-269011-230p8rsf	967	18	:	:	:
cord-269011-230p8rsf	968	1	Brief	brief	JJ
cord-269011-230p8rsf	968	2	report	report	NN
cord-269011-230p8rsf	968	3	Localization	Localization	NNP
cord-269011-230p8rsf	968	4	of	of	IN
cord-269011-230p8rsf	968	5	mouse	mouse	NN
cord-269011-230p8rsf	968	6	hepatitis	hepatitis	NN
cord-269011-230p8rsf	968	7	virus	virus	NN
cord-269011-230p8rsf	968	8	nonstructural	nonstructural	JJ
cord-269011-230p8rsf	968	9	proteins	protein	NNS
cord-269011-230p8rsf	968	10	and	and	CC
cord-269011-230p8rsf	968	11	RNA	RNA	NNP
cord-269011-230p8rsf	968	12	synthesis	synthesis	NN
cord-269011-230p8rsf	968	13	indicates	indicate	VBZ
cord-269011-230p8rsf	968	14	a	a	DT
cord-269011-230p8rsf	968	15	role	role	NN
cord-269011-230p8rsf	968	16	for	for	IN
cord-269011-230p8rsf	968	17	late	late	JJ
cord-269011-230p8rsf	968	18	endosomes	endosome	NNS
cord-269011-230p8rsf	968	19	in	in	IN
cord-269011-230p8rsf	968	20	viral	viral	JJ
cord-269011-230p8rsf	968	21	replication	replication	NN
cord-269011-230p8rsf	969	1	A	a	DT
cord-269011-230p8rsf	969	2	domain	domain	NN
cord-269011-230p8rsf	969	3	at	at	IN
cord-269011-230p8rsf	969	4	the	the	DT
cord-269011-230p8rsf	969	5	3	3	CD
cord-269011-230p8rsf	969	6	0	0	CD
cord-269011-230p8rsf	969	7	end	end	NN
cord-269011-230p8rsf	969	8	of	of	IN
cord-269011-230p8rsf	969	9	the	the	DT
cord-269011-230p8rsf	969	10	polymerase	polymerase	NN
cord-269011-230p8rsf	969	11	gene	gene	NN
cord-269011-230p8rsf	969	12	is	be	VBZ
cord-269011-230p8rsf	969	13	essential	essential	JJ
cord-269011-230p8rsf	969	14	for	for	IN
cord-269011-230p8rsf	969	15	encapsidation	encapsidation	NN
cord-269011-230p8rsf	969	16	of	of	IN
cord-269011-230p8rsf	969	17	coronavirus	coronavirus	NN
cord-269011-230p8rsf	969	18	defective	defective	JJ
cord-269011-230p8rsf	969	19	interfering	interfere	VBG
cord-269011-230p8rsf	969	20	RNAs	rna	NNS
cord-269011-230p8rsf	969	21	The	the	DT
cord-269011-230p8rsf	969	22	phospholipid	phospholipid	NN
cord-269011-230p8rsf	969	23	composition	composition	NN
cord-269011-230p8rsf	969	24	of	of	IN
cord-269011-230p8rsf	969	25	enveloped	envelop	VBN
cord-269011-230p8rsf	969	26	viruses	virus	NNS
cord-269011-230p8rsf	969	27	depends	depend	VBZ
cord-269011-230p8rsf	969	28	on	on	IN
cord-269011-230p8rsf	969	29	the	the	DT
cord-269011-230p8rsf	969	30	intracellular	intracellular	JJ
cord-269011-230p8rsf	969	31	membrane	membrane	NN
cord-269011-230p8rsf	969	32	through	through	IN
cord-269011-230p8rsf	969	33	which	which	WDT
cord-269011-230p8rsf	969	34	they	-PRON-	PRP
cord-269011-230p8rsf	969	35	bud	bud	VBP
cord-269011-230p8rsf	969	36	Genetic	genetic	JJ
cord-269011-230p8rsf	969	37	drift	drift	NN
cord-269011-230p8rsf	969	38	and	and	CC
cord-269011-230p8rsf	969	39	genetic	genetic	JJ
cord-269011-230p8rsf	969	40	shift	shift	NN
cord-269011-230p8rsf	969	41	during	during	IN
cord-269011-230p8rsf	969	42	feline	feline	JJ
cord-269011-230p8rsf	969	43	coronavirus	coronavirus	NN
cord-269011-230p8rsf	969	44	evolution	evolution	NN
cord-269011-230p8rsf	969	45	Nucleocapsid	nucleocapsid	JJ
cord-269011-230p8rsf	969	46	-	-	HYPH
cord-269011-230p8rsf	969	47	independent	independent	JJ
cord-269011-230p8rsf	969	48	assembly	assembly	NN
cord-269011-230p8rsf	969	49	of	of	IN
cord-269011-230p8rsf	969	50	coronavirus	coronavirus	NN
cord-269011-230p8rsf	969	51	-	-	HYPH
cord-269011-230p8rsf	969	52	like	like	JJ
cord-269011-230p8rsf	969	53	particles	particle	NNS
cord-269011-230p8rsf	969	54	by	by	IN
cord-269011-230p8rsf	969	55	co	co	NN
cord-269011-230p8rsf	969	56	-	-	NN
cord-269011-230p8rsf	969	57	expression	expression	NN
cord-269011-230p8rsf	969	58	of	of	IN
cord-269011-230p8rsf	969	59	viral	viral	JJ
cord-269011-230p8rsf	969	60	envelope	envelope	NN
cord-269011-230p8rsf	969	61	protein	protein	NN
cord-269011-230p8rsf	969	62	genes	gene	NNS
cord-269011-230p8rsf	970	1	Intracellular	intracellular	JJ
cord-269011-230p8rsf	970	2	transport	transport	NN
cord-269011-230p8rsf	970	3	of	of	IN
cord-269011-230p8rsf	970	4	recombinant	recombinant	JJ
cord-269011-230p8rsf	970	5	coronavirus	coronavirus	NN
cord-269011-230p8rsf	970	6	spike	spike	NN
cord-269011-230p8rsf	970	7	proteins	protein	NNS
cord-269011-230p8rsf	970	8	:	:	:
cord-269011-230p8rsf	970	9	Implications	implication	NNS
cord-269011-230p8rsf	970	10	for	for	IN
cord-269011-230p8rsf	970	11	virus	virus	NN
cord-269011-230p8rsf	970	12	assembly	assembly	NN
cord-269011-230p8rsf	970	13	Feline	feline	JJ
cord-269011-230p8rsf	970	14	infectious	infectious	JJ
cord-269011-230p8rsf	970	15	peritonitis	peritonitis	NN
cord-269011-230p8rsf	970	16	viruses	virus	NNS
cord-269011-230p8rsf	970	17	arise	arise	VBP
cord-269011-230p8rsf	970	18	by	by	IN
cord-269011-230p8rsf	970	19	mutation	mutation	NN
cord-269011-230p8rsf	970	20	from	from	IN
cord-269011-230p8rsf	970	21	endemic	endemic	JJ
cord-269011-230p8rsf	970	22	feline	feline	JJ
cord-269011-230p8rsf	970	23	enteric	enteric	JJ
cord-269011-230p8rsf	970	24	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	970	25	Biosynthesis	Biosynthesis	NNP
cord-269011-230p8rsf	970	26	and	and	CC
cord-269011-230p8rsf	970	27	function	function	NN
cord-269011-230p8rsf	970	28	of	of	IN
cord-269011-230p8rsf	970	29	the	the	DT
cord-269011-230p8rsf	970	30	coronavirus	coronavirus	NN
cord-269011-230p8rsf	970	31	spike	spike	NN
cord-269011-230p8rsf	970	32	protein	protein	NN
cord-269011-230p8rsf	971	1	The	the	DT
cord-269011-230p8rsf	971	2	E3	e3	NN
cord-269011-230p8rsf	971	3	protein	protein	NN
cord-269011-230p8rsf	971	4	of	of	IN
cord-269011-230p8rsf	971	5	bovine	bovine	JJ
cord-269011-230p8rsf	971	6	coronavirus	coronavirus	NN
cord-269011-230p8rsf	971	7	is	be	VBZ
cord-269011-230p8rsf	971	8	a	a	DT
cord-269011-230p8rsf	971	9	receptor	receptor	NN
cord-269011-230p8rsf	971	10	-	-	HYPH
cord-269011-230p8rsf	971	11	destroying	destroy	VBG
cord-269011-230p8rsf	971	12	enzyme	enzyme	NN
cord-269011-230p8rsf	971	13	with	with	IN
cord-269011-230p8rsf	971	14	acetylesterase	acetylesterase	NN
cord-269011-230p8rsf	971	15	activity	activity	NN
cord-269011-230p8rsf	971	16	Human	human	JJ
cord-269011-230p8rsf	971	17	and	and	CC
cord-269011-230p8rsf	971	18	bovine	bovine	JJ
cord-269011-230p8rsf	971	19	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	971	20	recognize	recognize	VBP
cord-269011-230p8rsf	971	21	sialic	sialic	JJ
cord-269011-230p8rsf	971	22	acid	acid	NN
cord-269011-230p8rsf	971	23	-	-	HYPH
cord-269011-230p8rsf	971	24	containing	contain	VBG
cord-269011-230p8rsf	971	25	receptors	receptor	NNS
cord-269011-230p8rsf	971	26	similar	similar	JJ
cord-269011-230p8rsf	971	27	to	to	IN
cord-269011-230p8rsf	971	28	those	those	DT
cord-269011-230p8rsf	971	29	of	of	IN
cord-269011-230p8rsf	971	30	influenza	influenza	NN
cord-269011-230p8rsf	971	31	C	c	NN
cord-269011-230p8rsf	971	32	viruses	virus	NNS
cord-269011-230p8rsf	972	1	The	the	DT
cord-269011-230p8rsf	972	2	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	972	3	protein	protein	NN
cord-269011-230p8rsf	972	4	of	of	IN
cord-269011-230p8rsf	972	5	coronavirus	coronavirus	NNP
cord-269011-230p8rsf	972	6	mouse	mouse	NN
cord-269011-230p8rsf	972	7	hepatitis	hepatitis	NN
cord-269011-230p8rsf	972	8	virus	virus	NN
cord-269011-230p8rsf	972	9	interacts	interact	VBZ
cord-269011-230p8rsf	972	10	with	with	IN
cord-269011-230p8rsf	972	11	the	the	DT
cord-269011-230p8rsf	972	12	cellular	cellular	JJ
cord-269011-230p8rsf	972	13	heterogeneous	heterogeneous	JJ
cord-269011-230p8rsf	972	14	nuclear	nuclear	JJ
cord-269011-230p8rsf	972	15	ribonucleoprotein	ribonucleoprotein	NN
cord-269011-230p8rsf	972	16	A1	A1	NNP
cord-269011-230p8rsf	972	17	in	in	IN
cord-269011-230p8rsf	972	18	vitro	vitro	FW
cord-269011-230p8rsf	972	19	and	and	CC
cord-269011-230p8rsf	972	20	in	in	IN
cord-269011-230p8rsf	972	21	vivo	vivo	NNP
cord-269011-230p8rsf	972	22	Structural	structural	JJ
cord-269011-230p8rsf	972	23	polypeptides	polypeptide	NNS
cord-269011-230p8rsf	972	24	of	of	IN
cord-269011-230p8rsf	972	25	the	the	DT
cord-269011-230p8rsf	972	26	murine	murine	JJ
cord-269011-230p8rsf	972	27	coronavirus	coronavirus	NN
cord-269011-230p8rsf	973	1	JHM	JHM	NNP
cord-269011-230p8rsf	973	2	Oligomerization	Oligomerization	NNP
cord-269011-230p8rsf	973	3	of	of	IN
cord-269011-230p8rsf	973	4	a	a	DT
cord-269011-230p8rsf	973	5	membrane	membrane	NN
cord-269011-230p8rsf	973	6	protein	protein	NN
cord-269011-230p8rsf	973	7	correlates	correlate	VBZ
cord-269011-230p8rsf	973	8	with	with	IN
cord-269011-230p8rsf	973	9	its	-PRON-	PRP$
cord-269011-230p8rsf	973	10	retention	retention	NN
cord-269011-230p8rsf	973	11	in	in	IN
cord-269011-230p8rsf	973	12	the	the	DT
cord-269011-230p8rsf	973	13	Golgi	Golgi	NNP
cord-269011-230p8rsf	973	14	complex	complex	JJ
cord-269011-230p8rsf	973	15	Phosphorylation	Phosphorylation	NNP
cord-269011-230p8rsf	973	16	of	of	IN
cord-269011-230p8rsf	973	17	the	the	DT
cord-269011-230p8rsf	973	18	mouse	mouse	NN
cord-269011-230p8rsf	973	19	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	973	20	virus	virus	NN
cord-269011-230p8rsf	973	21	nucleocapsid	nucleocapsid	NNP
cord-269011-230p8rsf	973	22	protein	protein	NNP
cord-269011-230p8rsf	974	1	The	the	DT
cord-269011-230p8rsf	974	2	replication	replication	NN
cord-269011-230p8rsf	974	3	of	of	IN
cord-269011-230p8rsf	974	4	murine	murine	JJ
cord-269011-230p8rsf	974	5	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	974	6	in	in	IN
cord-269011-230p8rsf	974	7	enucleated	enucleated	JJ
cord-269011-230p8rsf	974	8	cells	cell	NNS
cord-269011-230p8rsf	974	9	Receptor	Receptor	NNP
cord-269011-230p8rsf	974	10	for	for	IN
cord-269011-230p8rsf	974	11	mouse	mouse	NN
cord-269011-230p8rsf	974	12	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	974	13	virus	virus	NN
cord-269011-230p8rsf	974	14	is	be	VBZ
cord-269011-230p8rsf	974	15	a	a	DT
cord-269011-230p8rsf	974	16	member	member	NN
cord-269011-230p8rsf	974	17	of	of	IN
cord-269011-230p8rsf	974	18	the	the	DT
cord-269011-230p8rsf	974	19	carcinoembryonic	carcinoembryonic	NNP
cord-269011-230p8rsf	974	20	antigen	antigen	NNP
cord-269011-230p8rsf	974	21	family	family	NN
cord-269011-230p8rsf	974	22	of	of	IN
cord-269011-230p8rsf	974	23	glycoproteins	glycoprotein	NNS
cord-269011-230p8rsf	974	24	A	a	DT
cord-269011-230p8rsf	974	25	193-amino	193-amino	CD
cord-269011-230p8rsf	974	26	acid	acid	NN
cord-269011-230p8rsf	974	27	fragment	fragment	NN
cord-269011-230p8rsf	974	28	of	of	IN
cord-269011-230p8rsf	974	29	the	the	DT
cord-269011-230p8rsf	974	30	SARS	SARS	NNP
cord-269011-230p8rsf	974	31	coronavirus	coronavirus	NN
cord-269011-230p8rsf	974	32	S	S	NNP
cord-269011-230p8rsf	974	33	protein	protein	NN
cord-269011-230p8rsf	974	34	efficiently	efficiently	RB
cord-269011-230p8rsf	974	35	binds	bind	VBZ
cord-269011-230p8rsf	974	36	angiotensin	angiotensin	NN
cord-269011-230p8rsf	974	37	-	-	HYPH
cord-269011-230p8rsf	974	38	converting	convert	VBG
cord-269011-230p8rsf	974	39	enzyme	enzyme	NN
cord-269011-230p8rsf	974	40	2	2	CD
cord-269011-230p8rsf	974	41	Murine	murine	JJ
cord-269011-230p8rsf	974	42	coronavirus	coronavirus	NN
cord-269011-230p8rsf	974	43	packaging	packaging	NN
cord-269011-230p8rsf	974	44	signal	signal	NN
cord-269011-230p8rsf	974	45	confers	confer	VBZ
cord-269011-230p8rsf	974	46	packaging	packaging	NN
cord-269011-230p8rsf	974	47	to	to	IN
cord-269011-230p8rsf	974	48	nonviral	nonviral	NNP
cord-269011-230p8rsf	974	49	RNA	RNA	NNP
cord-269011-230p8rsf	974	50	Efficacy	Efficacy	NNP
cord-269011-230p8rsf	974	51	of	of	IN
cord-269011-230p8rsf	974	52	a	a	DT
cord-269011-230p8rsf	974	53	transmissible	transmissible	JJ
cord-269011-230p8rsf	974	54	gastroenteritis	gastroenteritis	NN
cord-269011-230p8rsf	974	55	coronavirus	coronavirus	NN
cord-269011-230p8rsf	974	56	with	with	IN
cord-269011-230p8rsf	974	57	an	an	DT
cord-269011-230p8rsf	974	58	altered	alter	VBN
cord-269011-230p8rsf	974	59	ORF-3	ORF-3	NNP
cord-269011-230p8rsf	974	60	gene	gene	NN
cord-269011-230p8rsf	974	61	Localization	localization	NN
cord-269011-230p8rsf	974	62	to	to	IN
cord-269011-230p8rsf	974	63	the	the	DT
cord-269011-230p8rsf	974	64	nucleolus	nucleolus	NN
cord-269011-230p8rsf	974	65	is	be	VBZ
cord-269011-230p8rsf	974	66	a	a	DT
cord-269011-230p8rsf	974	67	common	common	JJ
cord-269011-230p8rsf	974	68	feature	feature	NN
cord-269011-230p8rsf	974	69	of	of	IN
cord-269011-230p8rsf	974	70	coronavirus	coronavirus	NN
cord-269011-230p8rsf	974	71	nucleoproteins	nucleoprotein	NNS
cord-269011-230p8rsf	974	72	,	,	,
cord-269011-230p8rsf	974	73	and	and	CC
cord-269011-230p8rsf	974	74	the	the	DT
cord-269011-230p8rsf	974	75	protein	protein	NN
cord-269011-230p8rsf	974	76	may	may	MD
cord-269011-230p8rsf	974	77	disrupt	disrupt	VB
cord-269011-230p8rsf	974	78	host	host	NN
cord-269011-230p8rsf	974	79	cell	cell	NN
cord-269011-230p8rsf	974	80	division	division	NN
cord-269011-230p8rsf	975	1	The	the	DT
cord-269011-230p8rsf	975	2	sialate-4-O	sialate-4-o	NN
cord-269011-230p8rsf	975	3	-	-	HYPH
cord-269011-230p8rsf	975	4	acetylesterases	acetylesterase	NNS
cord-269011-230p8rsf	975	5	of	of	IN
cord-269011-230p8rsf	975	6	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	975	7	related	relate	VBN
cord-269011-230p8rsf	975	8	to	to	IN
cord-269011-230p8rsf	975	9	mouse	mouse	NNP
cord-269011-230p8rsf	975	10	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	975	11	virus	virus	NN
cord-269011-230p8rsf	975	12	:	:	:
cord-269011-230p8rsf	976	1	A	a	DT
cord-269011-230p8rsf	976	2	proposal	proposal	NN
cord-269011-230p8rsf	976	3	to	to	TO
cord-269011-230p8rsf	976	4	reorganize	reorganize	VB
cord-269011-230p8rsf	976	5	group	group	NN
cord-269011-230p8rsf	976	6	2	2	CD
cord-269011-230p8rsf	976	7	Coronaviridae	Coronaviridae	NNP
cord-269011-230p8rsf	976	8	Structural	structural	JJ
cord-269011-230p8rsf	976	9	basis	basis	NN
cord-269011-230p8rsf	976	10	for	for	IN
cord-269011-230p8rsf	976	11	coronavirus	coronavirus	NN
cord-269011-230p8rsf	976	12	-	-	HYPH
cord-269011-230p8rsf	976	13	mediated	mediate	VBN
cord-269011-230p8rsf	976	14	membrane	membrane	NN
cord-269011-230p8rsf	976	15	fusion	fusion	NN
cord-269011-230p8rsf	976	16	:	:	:
cord-269011-230p8rsf	976	17	Crystal	crystal	NN
cord-269011-230p8rsf	976	18	structure	structure	NN
cord-269011-230p8rsf	976	19	of	of	IN
cord-269011-230p8rsf	976	20	MHV	MHV	NNP
cord-269011-230p8rsf	976	21	spike	spike	NN
cord-269011-230p8rsf	976	22	protein	protein	NN
cord-269011-230p8rsf	976	23	fusion	fusion	NN
cord-269011-230p8rsf	976	24	core	core	NN
cord-269011-230p8rsf	976	25	Unique	Unique	NNP
cord-269011-230p8rsf	976	26	N	N	NNP
cord-269011-230p8rsf	976	27	-	-	HYPH
cord-269011-230p8rsf	976	28	linked	link	VBN
cord-269011-230p8rsf	976	29	glycosylation	glycosylation	NN
cord-269011-230p8rsf	976	30	of	of	IN
cord-269011-230p8rsf	976	31	murine	murine	JJ
cord-269011-230p8rsf	976	32	coronavirus	coronavirus	NN
cord-269011-230p8rsf	976	33	MHV-2	mhv-2	NN
cord-269011-230p8rsf	976	34	membrane	membrane	NN
cord-269011-230p8rsf	976	35	protein	protein	NN
cord-269011-230p8rsf	976	36	at	at	IN
cord-269011-230p8rsf	976	37	the	the	DT
cord-269011-230p8rsf	976	38	conserved	conserve	VBN
cord-269011-230p8rsf	976	39	O	o	NN
cord-269011-230p8rsf	976	40	-	-	HYPH
cord-269011-230p8rsf	976	41	linked	link	VBN
cord-269011-230p8rsf	976	42	glycosylation	glycosylation	NN
cord-269011-230p8rsf	976	43	site	site	NN
cord-269011-230p8rsf	976	44	Human	human	JJ
cord-269011-230p8rsf	976	45	aminopeptidase	aminopeptidase	NN
cord-269011-230p8rsf	977	1	N	N	NNP
cord-269011-230p8rsf	977	2	is	be	VBZ
cord-269011-230p8rsf	977	3	a	a	DT
cord-269011-230p8rsf	977	4	receptor	receptor	NN
cord-269011-230p8rsf	977	5	for	for	IN
cord-269011-230p8rsf	977	6	human	human	JJ
cord-269011-230p8rsf	977	7	coronavirus	coronavirus	NN
cord-269011-230p8rsf	977	8	229E	229e	CD
cord-269011-230p8rsf	977	9	Neuropathogenicity	Neuropathogenicity	NNP
cord-269011-230p8rsf	977	10	of	of	IN
cord-269011-230p8rsf	977	11	mouse	mouse	NN
cord-269011-230p8rsf	977	12	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	977	13	virus	virus	NN
cord-269011-230p8rsf	978	1	JHM	JHM	NNP
cord-269011-230p8rsf	978	2	isolates	isolate	VBZ
cord-269011-230p8rsf	978	3	differing	differ	VBG
cord-269011-230p8rsf	978	4	in	in	IN
cord-269011-230p8rsf	978	5	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	978	6	-	-	HYPH
cord-269011-230p8rsf	978	7	esterase	esterase	NN
cord-269011-230p8rsf	978	8	protein	protein	NN
cord-269011-230p8rsf	978	9	expression	expression	NN
cord-269011-230p8rsf	979	1	Hemagglutininesterase	hemagglutininesterase	JJ
cord-269011-230p8rsf	979	2	specific	specific	JJ
cord-269011-230p8rsf	979	3	monoclonalantibodies	monoclonalantibodie	NNS
cord-269011-230p8rsf	979	4	alter	alter	VBP
cord-269011-230p8rsf	979	5	the	the	DT
cord-269011-230p8rsf	979	6	neuropathogenicity	neuropathogenicity	NN
cord-269011-230p8rsf	979	7	of	of	IN
cord-269011-230p8rsf	979	8	mouse	mouse	NNP
cord-269011-230p8rsf	979	9	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	979	10	virus	virus	NN
cord-269011-230p8rsf	979	11	Heterogeneity	heterogeneity	NN
cord-269011-230p8rsf	979	12	of	of	IN
cord-269011-230p8rsf	979	13	gene	gene	NN
cord-269011-230p8rsf	979	14	expression	expression	NN
cord-269011-230p8rsf	979	15	of	of	IN
cord-269011-230p8rsf	979	16	the	the	DT
cord-269011-230p8rsf	979	17	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	979	18	-	-	HYPH
cord-269011-230p8rsf	979	19	esterase	esterase	NN
cord-269011-230p8rsf	979	20	(	(	-LRB-
cord-269011-230p8rsf	979	21	HE	he	NN
cord-269011-230p8rsf	979	22	)	)	-RRB-
cord-269011-230p8rsf	979	23	protein	protein	NN
cord-269011-230p8rsf	979	24	of	of	IN
cord-269011-230p8rsf	979	25	murine	murine	JJ
cord-269011-230p8rsf	979	26	coronaviruses	coronaviruse	NNS
cord-269011-230p8rsf	980	1	Biosynthesis	Biosynthesis	NNP
cord-269011-230p8rsf	980	2	,	,	,
cord-269011-230p8rsf	980	3	structure	structure	NN
cord-269011-230p8rsf	980	4	,	,	,
cord-269011-230p8rsf	980	5	and	and	CC
cord-269011-230p8rsf	980	6	biological	biological	JJ
cord-269011-230p8rsf	980	7	activities	activity	NNS
cord-269011-230p8rsf	980	8	of	of	IN
cord-269011-230p8rsf	980	9	envelope	envelope	NN
cord-269011-230p8rsf	980	10	protein	protein	NN
cord-269011-230p8rsf	980	11	gp65	gp65	NNP
cord-269011-230p8rsf	980	12	of	of	IN
cord-269011-230p8rsf	980	13	murine	murine	JJ
cord-269011-230p8rsf	980	14	coronavirus	coronavirus	NN
cord-269011-230p8rsf	981	1	The	the	DT
cord-269011-230p8rsf	981	2	detection	detection	NN
cord-269011-230p8rsf	981	3	and	and	CC
cord-269011-230p8rsf	981	4	characterization	characterization	NN
cord-269011-230p8rsf	981	5	of	of	IN
cord-269011-230p8rsf	981	6	multiple	multiple	JJ
cord-269011-230p8rsf	981	7	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	981	8	-	-	HYPH
cord-269011-230p8rsf	981	9	esterase	esterase	NN
cord-269011-230p8rsf	981	10	(	(	-LRB-
cord-269011-230p8rsf	981	11	HE)-defective	he)-defective	CD
cord-269011-230p8rsf	981	12	viruses	virus	NNS
cord-269011-230p8rsf	981	13	in	in	IN
cord-269011-230p8rsf	981	14	the	the	DT
cord-269011-230p8rsf	981	15	mouse	mouse	NN
cord-269011-230p8rsf	981	16	brain	brain	NN
cord-269011-230p8rsf	981	17	during	during	IN
cord-269011-230p8rsf	981	18	subacute	subacute	JJ
cord-269011-230p8rsf	981	19	demyelination	demyelination	NN
cord-269011-230p8rsf	981	20	induced	induce	VBN
cord-269011-230p8rsf	981	21	by	by	IN
cord-269011-230p8rsf	981	22	mouse	mouse	NNP
cord-269011-230p8rsf	981	23	hepatitis	hepatitis	NNP
cord-269011-230p8rsf	981	24	virus	virus	NN
cord-269011-230p8rsf	981	25	Synthesis	Synthesis	NNP
cord-269011-230p8rsf	981	26	and	and	CC
cord-269011-230p8rsf	981	27	processing	processing	NN
cord-269011-230p8rsf	981	28	of	of	IN
cord-269011-230p8rsf	981	29	the	the	DT
cord-269011-230p8rsf	981	30	haemagglutinin	haemagglutinin	JJ
cord-269011-230p8rsf	981	31	-	-	HYPH
cord-269011-230p8rsf	981	32	esterase	esterase	NN
cord-269011-230p8rsf	981	33	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	981	34	of	of	IN
cord-269011-230p8rsf	981	35	bovine	bovine	JJ
cord-269011-230p8rsf	981	36	coronavirus	coronavirus	NN
cord-269011-230p8rsf	981	37	encoded	encode	VBN
cord-269011-230p8rsf	981	38	in	in	IN
cord-269011-230p8rsf	981	39	the	the	DT
cord-269011-230p8rsf	981	40	E3	E3	NNP
cord-269011-230p8rsf	981	41	region	region	NN
cord-269011-230p8rsf	981	42	of	of	IN
cord-269011-230p8rsf	981	43	adenovirus	adenovirus	NN
cord-269011-230p8rsf	981	44	Mouse	Mouse	NNP
cord-269011-230p8rsf	981	45	hepatitis	hepatitis	NN
cord-269011-230p8rsf	981	46	virus	virus	NN
cord-269011-230p8rsf	981	47	strain	strain	VBP
cord-269011-230p8rsf	981	48	MHV	MHV	NNP
cord-269011-230p8rsf	981	49	-	-	HYPH
cord-269011-230p8rsf	981	50	S	s	NN
cord-269011-230p8rsf	981	51	:	:	:
cord-269011-230p8rsf	982	1	Formation	formation	NN
cord-269011-230p8rsf	982	2	of	of	IN
cord-269011-230p8rsf	982	3	pseudotypes	pseudotype	NNS
cord-269011-230p8rsf	982	4	with	with	IN
cord-269011-230p8rsf	982	5	a	a	DT
cord-269011-230p8rsf	982	6	murine	murine	JJ
cord-269011-230p8rsf	982	7	leukemia	leukemia	NN
cord-269011-230p8rsf	982	8	virus	virus	NN
cord-269011-230p8rsf	982	9	envelope	envelope	NN
cord-269011-230p8rsf	983	1	Mouse	Mouse	NNP
cord-269011-230p8rsf	983	2	hepatitis	hepatitis	NN
cord-269011-230p8rsf	983	3	virus	virus	NN
cord-269011-230p8rsf	983	4	gene	gene	NN
cord-269011-230p8rsf	983	5	5b	5b	CD
cord-269011-230p8rsf	983	6	protein	protein	NN
cord-269011-230p8rsf	983	7	is	be	VBZ
cord-269011-230p8rsf	984	1	a	a	DT
cord-269011-230p8rsf	984	2	new	new	JJ
cord-269011-230p8rsf	984	3	virion	virion	NN
cord-269011-230p8rsf	984	4	envelope	envelope	NN
cord-269011-230p8rsf	984	5	protein	protein	NN
cord-269011-230p8rsf	984	6	Suppression	Suppression	NNP
cord-269011-230p8rsf	984	7	of	of	IN
cord-269011-230p8rsf	984	8	SARS	SARS	NNP
cord-269011-230p8rsf	984	9	-	-	HYPH
cord-269011-230p8rsf	984	10	CoV	CoV	NNP
cord-269011-230p8rsf	984	11	entry	entry	NN
cord-269011-230p8rsf	984	12	by	by	IN
cord-269011-230p8rsf	984	13	peptides	peptide	NNS
cord-269011-230p8rsf	984	14	corresponding	correspond	VBG
cord-269011-230p8rsf	984	15	to	to	IN
cord-269011-230p8rsf	984	16	heptad	heptad	NN
cord-269011-230p8rsf	984	17	regions	region	NNS
cord-269011-230p8rsf	984	18	on	on	IN
cord-269011-230p8rsf	984	19	spike	spike	NN
cord-269011-230p8rsf	984	20	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	984	21	Conformational	Conformational	NNP
cord-269011-230p8rsf	984	22	changes	change	NNS
cord-269011-230p8rsf	984	23	in	in	IN
cord-269011-230p8rsf	984	24	the	the	DT
cord-269011-230p8rsf	984	25	spike	spike	NN
cord-269011-230p8rsf	984	26	glycoprotein	glycoprotein	NN
cord-269011-230p8rsf	984	27	of	of	IN
cord-269011-230p8rsf	984	28	murine	murine	JJ
cord-269011-230p8rsf	984	29	coronavirus	coronavirus	NN
cord-269011-230p8rsf	984	30	are	be	VBP
cord-269011-230p8rsf	984	31	induced	induce	VBN
cord-269011-230p8rsf	984	32	at	at	IN
cord-269011-230p8rsf	984	33	37	37	CD
cord-269011-230p8rsf	984	34	C	c	NN
cord-269011-230p8rsf	984	35	either	either	CC
cord-269011-230p8rsf	984	36	by	by	IN
cord-269011-230p8rsf	984	37	soluble	soluble	JJ
cord-269011-230p8rsf	984	38	murine	murine	JJ
cord-269011-230p8rsf	984	39	CEACAM1	CEACAM1	NNP
cord-269011-230p8rsf	984	40	receptors	receptor	NNS
cord-269011-230p8rsf	984	41	or	or	CC
cord-269011-230p8rsf	984	42	by	by	IN
cord-269011-230p8rsf	984	43	pH	pH	NNP
cord-269011-230p8rsf	984	44	8	8	CD
cord-269011-230p8rsf	984	45	Expression	expression	NN
cord-269011-230p8rsf	984	46	of	of	IN
cord-269011-230p8rsf	984	47	hemagglutinin	hemagglutinin	NN
cord-269011-230p8rsf	984	48	/	/	SYM
cord-269011-230p8rsf	984	49	esterase	esterase	NN
cord-269011-230p8rsf	984	50	by	by	IN
cord-269011-230p8rsf	984	51	a	a	DT
cord-269011-230p8rsf	984	52	mouse	mouse	NN
cord-269011-230p8rsf	984	53	hepatitis	hepatitis	NN
cord-269011-230p8rsf	984	54	virus	virus	NN
cord-269011-230p8rsf	984	55	coronavirus	coronavirus	NN
cord-269011-230p8rsf	984	56	defective	defective	JJ
cord-269011-230p8rsf	984	57	-	-	HYPH
cord-269011-230p8rsf	984	58	interfering	interfere	VBG
cord-269011-230p8rsf	984	59	RNA	RNA	NNP
cord-269011-230p8rsf	984	60	alters	alter	VBZ
cord-269011-230p8rsf	984	61	viral	viral	JJ
cord-269011-230p8rsf	984	62	pathogenesis	pathogenesis	NN
cord-269011-230p8rsf	984	63	Presence	Presence	NNP
cord-269011-230p8rsf	984	64	of	of	IN
cord-269011-230p8rsf	984	65	subgenomic	subgenomic	NNP
cord-269011-230p8rsf	984	66	mRNAs	mRNAs	NNPS
cord-269011-230p8rsf	984	67	in	in	IN
cord-269011-230p8rsf	984	68	virions	virion	NNS
cord-269011-230p8rsf	984	69	of	of	IN
cord-269011-230p8rsf	984	70	coronavirus	coronavirus	NN
cord-269011-230p8rsf	984	71	IBV	IBV	NNP
cord-269011-230p8rsf	984	72	The	the	DT
cord-269011-230p8rsf	984	73	amino	amino	NNS
cord-269011-230p8rsf	984	74	and	and	CC
cord-269011-230p8rsf	984	75	carboxyl	carboxyl	NN
cord-269011-230p8rsf	984	76	domains	domain	NNS
cord-269011-230p8rsf	984	77	of	of	IN
cord-269011-230p8rsf	984	78	the	the	DT
cord-269011-230p8rsf	984	79	infectious	infectious	JJ
cord-269011-230p8rsf	984	80	bronchitis	bronchitis	NN
cord-269011-230p8rsf	984	81	virus	virus	NN
cord-269011-230p8rsf	984	82	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	984	83	protein	protein	NNP
cord-269011-230p8rsf	984	84	interact	interact	VBP
cord-269011-230p8rsf	984	85	with	with	IN
cord-269011-230p8rsf	984	86	3	3	CD
cord-269011-230p8rsf	984	87	0	0	CD
cord-269011-230p8rsf	984	88	genomic	genomic	JJ
cord-269011-230p8rsf	984	89	RNA	rna	NN
cord-269011-230p8rsf	985	1	The	the	DT
cord-269011-230p8rsf	985	2	infectious	infectious	JJ
cord-269011-230p8rsf	985	3	bronchitis	bronchitis	NN
cord-269011-230p8rsf	985	4	virus	virus	NN
cord-269011-230p8rsf	985	5	nucleocapsid	nucleocapsid	NN
cord-269011-230p8rsf	985	6	protein	protein	NN
cord-269011-230p8rsf	985	7	binds	bind	VBZ
cord-269011-230p8rsf	985	8	RNA	RNA	NNP
cord-269011-230p8rsf	985	9	sequences	sequence	NNS
cord-269011-230p8rsf	985	10	in	in	IN
cord-269011-230p8rsf	985	11	the	the	DT
cord-269011-230p8rsf	985	12	3	3	CD
cord-269011-230p8rsf	985	13	0	0	CD
cord-269011-230p8rsf	985	14	terminus	terminus	NN
cord-269011-230p8rsf	985	15	of	of	IN
cord-269011-230p8rsf	985	16	the	the	DT
cord-269011-230p8rsf	985	17	genome	genome	NN
cord-269011-230p8rsf	985	18	Following	follow	VBG
cord-269011-230p8rsf	985	19	the	the	DT
cord-269011-230p8rsf	985	20	rule	rule	NN
cord-269011-230p8rsf	985	21	:	:	:
cord-269011-230p8rsf	985	22	Formation	formation	NN
cord-269011-230p8rsf	985	23	of	of	IN
cord-269011-230p8rsf	985	24	the	the	DT
cord-269011-230p8rsf	985	25	6-helix	6-helix	CD
cord-269011-230p8rsf	985	26	bundle	bundle	NN
cord-269011-230p8rsf	985	27	of	of	IN
cord-269011-230p8rsf	985	28	the	the	DT
cord-269011-230p8rsf	985	29	fusion	fusion	NN
cord-269011-230p8rsf	985	30	core	core	NN
cord-269011-230p8rsf	985	31	from	from	IN
cord-269011-230p8rsf	985	32	severe	severe	JJ
cord-269011-230p8rsf	985	33	acute	acute	JJ
cord-269011-230p8rsf	985	34	respiratory	respiratory	JJ
cord-269011-230p8rsf	985	35	syndrome	syndrome	NN
cord-269011-230p8rsf	985	36	coronavirus	coronavirus	NN
cord-269011-230p8rsf	985	37	spike	spike	NN
cord-269011-230p8rsf	985	38	protein	protein	NN
cord-269011-230p8rsf	985	39	and	and	CC
cord-269011-230p8rsf	985	40	identification	identification	NN
cord-269011-230p8rsf	985	41	of	of	IN
cord-269011-230p8rsf	985	42	potent	potent	JJ
cord-269011-230p8rsf	985	43	peptide	peptide	NN
cord-269011-230p8rsf	985	44	inhibitors	inhibitor	NNS
cord-269011-230p8rsf	985	45	Virus	virus	NN
cord-269011-230p8rsf	985	46	-	-	HYPH
cord-269011-230p8rsf	985	47	encoded	encode	VBN
cord-269011-230p8rsf	985	48	proteinases	proteinase	NNS
cord-269011-230p8rsf	985	49	and	and	CC
cord-269011-230p8rsf	985	50	proteolytic	proteolytic	JJ
cord-269011-230p8rsf	985	51	processing	processing	NN
cord-269011-230p8rsf	985	52	in	in	IN
cord-269011-230p8rsf	985	53	the	the	DT
cord-269011-230p8rsf	985	54	Nidovirales	Nidovirales	NNP
cord-269011-230p8rsf	986	1	We	-PRON-	PRP
cord-269011-230p8rsf	986	2	thank	thank	VBP
cord-269011-230p8rsf	986	3	Henk	Henk	NNP
cord-269011-230p8rsf	986	4	Halsema	Halsema	NNP
cord-269011-230p8rsf	986	5	for	for	IN
cord-269011-230p8rsf	986	6	making	make	VBG
cord-269011-230p8rsf	986	7	most	most	JJS
cord-269011-230p8rsf	986	8	of	of	IN
cord-269011-230p8rsf	986	9	the	the	DT
cord-269011-230p8rsf	986	10	drawings	drawing	NNS
cord-269011-230p8rsf	986	11	.	.	.
cord-269011-230p8rsf	987	1	We	-PRON-	PRP
cord-269011-230p8rsf	987	2	are	be	VBP
cord-269011-230p8rsf	987	3	grateful	grateful	JJ
cord-269011-230p8rsf	987	4	to	to	IN
cord-269011-230p8rsf	987	5	Cristina	Cristina	NNP
cord-269011-230p8rsf	987	6	Risco	Risco	NNP
cord-269011-230p8rsf	987	7	for	for	IN
cord-269011-230p8rsf	987	8	providing	provide	VBG
cord-269011-230p8rsf	987	9	the	the	DT
cord-269011-230p8rsf	987	10	electron	electron	NN
cord-269011-230p8rsf	987	11	micrographs	micrograph	NNS
cord-269011-230p8rsf	987	12	demonstrating	demonstrate	VBG
cord-269011-230p8rsf	987	13	the	the	DT
cord-269011-230p8rsf	987	14	structural	structural	JJ
cord-269011-230p8rsf	987	15	maturation	maturation	NN
cord-269011-230p8rsf	987	16	of	of	IN
cord-269011-230p8rsf	987	17	virions	virion	NNS
cord-269011-230p8rsf	987	18	;	;	:
cord-269011-230p8rsf	987	19	to	to	IN
cord-269011-230p8rsf	987	20	Raoul	Raoul	NNP
cord-269011-230p8rsf	987	21	de	de	NNP
cord-269011-230p8rsf	987	22	Groot	Groot	NNP
cord-269011-230p8rsf	987	23	,	,	,
cord-269011-230p8rsf	987	24	Berend	Berend	NNP
cord-269011-230p8rsf	987	25	Jan	Jan	NNP
cord-269011-230p8rsf	987	26	Bosch	Bosch	NNP
cord-269011-230p8rsf	987	27	,	,	,
cord-269011-230p8rsf	987	28	and	and	CC
cord-269011-230p8rsf	987	29	Jean	Jean	NNP
cord-269011-230p8rsf	987	30	Lepault	Lepault	NNP
cord-269011-230p8rsf	987	31	for	for	IN
cord-269011-230p8rsf	987	32	their	-PRON-	PRP$
cord-269011-230p8rsf	987	33	combined	combine	VBN
cord-269011-230p8rsf	987	34	efforts	effort	NNS
cord-269011-230p8rsf	987	35	in	in	IN
cord-269011-230p8rsf	987	36	providing	provide	VBG
cord-269011-230p8rsf	987	37	the	the	DT
cord-269011-230p8rsf	987	38	electron	electron	NN
cord-269011-230p8rsf	987	39	micrographs	micrograph	NNS
cord-269011-230p8rsf	987	40	of	of	IN
cord-269011-230p8rsf	987	41	the	the	DT
cord-269011-230p8rsf	987	42	purified	purify	VBN
cord-269011-230p8rsf	987	43	virions	virion	NNS
cord-269011-230p8rsf	987	44	;	;	:
cord-269011-230p8rsf	987	45	and	and	CC
cord-269011-230p8rsf	987	46	to	to	IN
cord-269011-230p8rsf	987	47	Raoul	Raoul	NNP
cord-269011-230p8rsf	987	48	de	de	NNP
cord-269011-230p8rsf	987	49	Groot	Groot	NNP
cord-269011-230p8rsf	987	50	for	for	IN
cord-269011-230p8rsf	987	51	critical	critical	JJ
cord-269011-230p8rsf	987	52	reading	reading	NN
cord-269011-230p8rsf	987	53	of	of	IN
cord-269011-230p8rsf	987	54	the	the	DT
cord-269011-230p8rsf	987	55	manuscript	manuscript	NN
cord-269011-230p8rsf	987	56	.	.	.