id sid tid token lemma pos cord-023865-6rafp3x3 1 1 key key NN cord-023865-6rafp3x3 1 2 : : : cord-023865-6rafp3x3 2 1 cord-023865 cord-023865 NNP cord-023865-6rafp3x3 2 2 - - : cord-023865-6rafp3x3 2 3 6rafp3x3 6rafp3x3 CD cord-023865-6rafp3x3 3 1 authors author NNS cord-023865-6rafp3x3 3 2 : : : cord-023865-6rafp3x3 3 3 Surjit Surjit NNP cord-023865-6rafp3x3 3 4 , , , cord-023865-6rafp3x3 3 5 Milan Milan NNP cord-023865-6rafp3x3 3 6 ; ; : cord-023865-6rafp3x3 3 7 Lal Lal NNP cord-023865-6rafp3x3 3 8 , , , cord-023865-6rafp3x3 4 1 Sunil Sunil NNP cord-023865-6rafp3x3 4 2 K. K. NNP cord-023865-6rafp3x3 4 3 title title NN cord-023865-6rafp3x3 4 4 : : : cord-023865-6rafp3x3 4 5 The the DT cord-023865-6rafp3x3 4 6 Nucleocapsid Nucleocapsid NNP cord-023865-6rafp3x3 4 7 Protein Protein NNP cord-023865-6rafp3x3 4 8 of of IN cord-023865-6rafp3x3 4 9 the the DT cord-023865-6rafp3x3 4 10 SARS SARS NNP cord-023865-6rafp3x3 4 11 Coronavirus Coronavirus NNP cord-023865-6rafp3x3 4 12 : : : cord-023865-6rafp3x3 4 13 Structure Structure NNP cord-023865-6rafp3x3 4 14 , , , cord-023865-6rafp3x3 4 15 Function Function NNP cord-023865-6rafp3x3 4 16 and and CC cord-023865-6rafp3x3 4 17 Therapeutic therapeutic JJ cord-023865-6rafp3x3 4 18 Potential potential JJ cord-023865-6rafp3x3 4 19 date date NN cord-023865-6rafp3x3 4 20 : : : cord-023865-6rafp3x3 4 21 2009 2009 CD cord-023865-6rafp3x3 4 22 - - SYM cord-023865-6rafp3x3 4 23 07 07 CD cord-023865-6rafp3x3 4 24 - - HYPH cord-023865-6rafp3x3 4 25 22 22 CD cord-023865-6rafp3x3 4 26 journal journal NN cord-023865-6rafp3x3 4 27 : : : cord-023865-6rafp3x3 5 1 Molecular molecular JJ cord-023865-6rafp3x3 5 2 Biology biology NN cord-023865-6rafp3x3 5 3 of of IN cord-023865-6rafp3x3 5 4 the the DT cord-023865-6rafp3x3 5 5 SARS SARS NNP cord-023865-6rafp3x3 5 6 - - HYPH cord-023865-6rafp3x3 5 7 Coronavirus Coronavirus NNP cord-023865-6rafp3x3 5 8 DOI doi NN cord-023865-6rafp3x3 5 9 : : : cord-023865-6rafp3x3 5 10 10.1007/978 10.1007/978 CD cord-023865-6rafp3x3 5 11 - - HYPH cord-023865-6rafp3x3 5 12 3 3 CD cord-023865-6rafp3x3 5 13 - - HYPH cord-023865-6rafp3x3 5 14 642 642 CD cord-023865-6rafp3x3 5 15 - - HYPH cord-023865-6rafp3x3 5 16 03683 03683 CD cord-023865-6rafp3x3 5 17 - - SYM cord-023865-6rafp3x3 5 18 5_9 5_9 CD cord-023865-6rafp3x3 5 19 sha sha NN cord-023865-6rafp3x3 5 20 : : : cord-023865-6rafp3x3 5 21 5aa833ef86996b92cba4e3388c462761f1dab186 5aa833ef86996b92cba4e3388c462761f1dab186 CD cord-023865-6rafp3x3 5 22 doc_id doc_id CD cord-023865-6rafp3x3 5 23 : : : cord-023865-6rafp3x3 5 24 23865 23865 CD cord-023865-6rafp3x3 5 25 cord_uid cord_uid NNS cord-023865-6rafp3x3 5 26 : : : cord-023865-6rafp3x3 5 27 6rafp3x3 6rafp3x3 CD cord-023865-6rafp3x3 6 1 As as IN cord-023865-6rafp3x3 6 2 in in IN cord-023865-6rafp3x3 6 3 other other JJ cord-023865-6rafp3x3 6 4 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 6 5 , , , cord-023865-6rafp3x3 6 6 the the DT cord-023865-6rafp3x3 6 7 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 6 8 protein protein NN cord-023865-6rafp3x3 6 9 is be VBZ cord-023865-6rafp3x3 6 10 one one CD cord-023865-6rafp3x3 6 11 of of IN cord-023865-6rafp3x3 6 12 the the DT cord-023865-6rafp3x3 6 13 core core NN cord-023865-6rafp3x3 6 14 components component NNS cord-023865-6rafp3x3 6 15 of of IN cord-023865-6rafp3x3 6 16 the the DT cord-023865-6rafp3x3 6 17 SARS SARS NNP cord-023865-6rafp3x3 6 18 coronavirus coronavirus NN cord-023865-6rafp3x3 6 19 ( ( -LRB- cord-023865-6rafp3x3 6 20 CoV CoV NNP cord-023865-6rafp3x3 6 21 ) ) -RRB- cord-023865-6rafp3x3 6 22 . . . cord-023865-6rafp3x3 7 1 It -PRON- PRP cord-023865-6rafp3x3 7 2 oligomerizes oligomerize VBZ cord-023865-6rafp3x3 7 3 to to TO cord-023865-6rafp3x3 7 4 form form VB cord-023865-6rafp3x3 7 5 a a DT cord-023865-6rafp3x3 7 6 closed closed JJ cord-023865-6rafp3x3 7 7 capsule capsule NN cord-023865-6rafp3x3 7 8 , , , cord-023865-6rafp3x3 7 9 inside inside IN cord-023865-6rafp3x3 7 10 which which WDT cord-023865-6rafp3x3 7 11 the the DT cord-023865-6rafp3x3 7 12 genomic genomic JJ cord-023865-6rafp3x3 7 13 RNA RNA NNP cord-023865-6rafp3x3 7 14 is be VBZ cord-023865-6rafp3x3 7 15 securely securely RB cord-023865-6rafp3x3 7 16 stored store VBN cord-023865-6rafp3x3 7 17 thus thus RB cord-023865-6rafp3x3 7 18 providing provide VBG cord-023865-6rafp3x3 7 19 the the DT cord-023865-6rafp3x3 7 20 SARS SARS NNP cord-023865-6rafp3x3 7 21 - - HYPH cord-023865-6rafp3x3 7 22 CoV CoV NNP cord-023865-6rafp3x3 7 23 genome genome NN cord-023865-6rafp3x3 7 24 with with IN cord-023865-6rafp3x3 7 25 its -PRON- PRP$ cord-023865-6rafp3x3 7 26 first first JJ cord-023865-6rafp3x3 7 27 line line NN cord-023865-6rafp3x3 7 28 of of IN cord-023865-6rafp3x3 7 29 defense defense NN cord-023865-6rafp3x3 7 30 from from IN cord-023865-6rafp3x3 7 31 the the DT cord-023865-6rafp3x3 7 32 harsh harsh JJ cord-023865-6rafp3x3 7 33 conditions condition NNS cord-023865-6rafp3x3 7 34 of of IN cord-023865-6rafp3x3 7 35 the the DT cord-023865-6rafp3x3 7 36 host host NN cord-023865-6rafp3x3 7 37 environment environment NN cord-023865-6rafp3x3 7 38 and and CC cord-023865-6rafp3x3 7 39 aiding aid VBG cord-023865-6rafp3x3 7 40 in in IN cord-023865-6rafp3x3 7 41 replication replication NN cord-023865-6rafp3x3 7 42 and and CC cord-023865-6rafp3x3 7 43 propagation propagation NN cord-023865-6rafp3x3 7 44 of of IN cord-023865-6rafp3x3 7 45 the the DT cord-023865-6rafp3x3 7 46 virus virus NN cord-023865-6rafp3x3 7 47 . . . cord-023865-6rafp3x3 8 1 In in IN cord-023865-6rafp3x3 8 2 addition addition NN cord-023865-6rafp3x3 8 3 to to IN cord-023865-6rafp3x3 8 4 this this DT cord-023865-6rafp3x3 8 5 function function NN cord-023865-6rafp3x3 8 6 , , , cord-023865-6rafp3x3 8 7 several several JJ cord-023865-6rafp3x3 8 8 reports report NNS cord-023865-6rafp3x3 8 9 have have VBP cord-023865-6rafp3x3 8 10 suggested suggest VBN cord-023865-6rafp3x3 8 11 that that IN cord-023865-6rafp3x3 8 12 the the DT cord-023865-6rafp3x3 8 13 SARS SARS NNP cord-023865-6rafp3x3 8 14 - - HYPH cord-023865-6rafp3x3 8 15 CoV CoV NNP cord-023865-6rafp3x3 8 16 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 8 17 protein protein NNP cord-023865-6rafp3x3 8 18 modulates modulate VBZ cord-023865-6rafp3x3 8 19 various various JJ cord-023865-6rafp3x3 8 20 host host NN cord-023865-6rafp3x3 8 21 cellular cellular JJ cord-023865-6rafp3x3 8 22 processes process NNS cord-023865-6rafp3x3 8 23 , , , cord-023865-6rafp3x3 8 24 so so IN cord-023865-6rafp3x3 8 25 as as IN cord-023865-6rafp3x3 8 26 to to TO cord-023865-6rafp3x3 8 27 make make VB cord-023865-6rafp3x3 8 28 the the DT cord-023865-6rafp3x3 8 29 internal internal JJ cord-023865-6rafp3x3 8 30 milieu milieu NN cord-023865-6rafp3x3 8 31 of of IN cord-023865-6rafp3x3 8 32 the the DT cord-023865-6rafp3x3 8 33 host host NN cord-023865-6rafp3x3 8 34 more more RBR cord-023865-6rafp3x3 8 35 conducive conducive JJ cord-023865-6rafp3x3 8 36 for for IN cord-023865-6rafp3x3 8 37 survival survival NN cord-023865-6rafp3x3 8 38 of of IN cord-023865-6rafp3x3 8 39 the the DT cord-023865-6rafp3x3 8 40 virus virus NN cord-023865-6rafp3x3 8 41 . . . cord-023865-6rafp3x3 9 1 This this DT cord-023865-6rafp3x3 9 2 article article NN cord-023865-6rafp3x3 9 3 will will MD cord-023865-6rafp3x3 9 4 analyze analyze VB cord-023865-6rafp3x3 9 5 and and CC cord-023865-6rafp3x3 9 6 discuss discuss VB cord-023865-6rafp3x3 9 7 the the DT cord-023865-6rafp3x3 9 8 available available JJ cord-023865-6rafp3x3 9 9 literature literature NN cord-023865-6rafp3x3 9 10 regarding regard VBG cord-023865-6rafp3x3 9 11 these these DT cord-023865-6rafp3x3 9 12 different different JJ cord-023865-6rafp3x3 9 13 properties property NNS cord-023865-6rafp3x3 9 14 of of IN cord-023865-6rafp3x3 9 15 the the DT cord-023865-6rafp3x3 9 16 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 9 17 protein protein NN cord-023865-6rafp3x3 9 18 . . . cord-023865-6rafp3x3 10 1 Towards towards IN cord-023865-6rafp3x3 10 2 the the DT cord-023865-6rafp3x3 10 3 end end NN cord-023865-6rafp3x3 10 4 of of IN cord-023865-6rafp3x3 10 5 the the DT cord-023865-6rafp3x3 10 6 article article NN cord-023865-6rafp3x3 10 7 , , , cord-023865-6rafp3x3 10 8 we -PRON- PRP cord-023865-6rafp3x3 10 9 will will MD cord-023865-6rafp3x3 10 10 also also RB cord-023865-6rafp3x3 10 11 discuss discuss VB cord-023865-6rafp3x3 10 12 some some DT cord-023865-6rafp3x3 10 13 recent recent JJ cord-023865-6rafp3x3 10 14 reports report NNS cord-023865-6rafp3x3 10 15 regarding regard VBG cord-023865-6rafp3x3 10 16 the the DT cord-023865-6rafp3x3 10 17 possible possible JJ cord-023865-6rafp3x3 10 18 clinically clinically RB cord-023865-6rafp3x3 10 19 relevant relevant JJ cord-023865-6rafp3x3 10 20 use use NN cord-023865-6rafp3x3 10 21 of of IN cord-023865-6rafp3x3 10 22 the the DT cord-023865-6rafp3x3 10 23 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 10 24 protein protein NN cord-023865-6rafp3x3 10 25 , , , cord-023865-6rafp3x3 10 26 as as IN cord-023865-6rafp3x3 10 27 a a DT cord-023865-6rafp3x3 10 28 candidate candidate NN cord-023865-6rafp3x3 10 29 diagnostic diagnostic JJ cord-023865-6rafp3x3 10 30 tool tool NN cord-023865-6rafp3x3 10 31 and and CC cord-023865-6rafp3x3 10 32 vaccine vaccine NN cord-023865-6rafp3x3 10 33 against against IN cord-023865-6rafp3x3 10 34 SARS SARS NNP cord-023865-6rafp3x3 10 35 - - HYPH cord-023865-6rafp3x3 10 36 CoV CoV NNP cord-023865-6rafp3x3 10 37 infection infection NN cord-023865-6rafp3x3 10 38 . . . cord-023865-6rafp3x3 11 1 By by IN cord-023865-6rafp3x3 11 2 definition definition NN cord-023865-6rafp3x3 11 3 , , , cord-023865-6rafp3x3 11 4 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 11 5 is be VBZ cord-023865-6rafp3x3 11 6 a a DT cord-023865-6rafp3x3 11 7 viral viral JJ cord-023865-6rafp3x3 11 8 protein protein NN cord-023865-6rafp3x3 11 9 coat coat NN cord-023865-6rafp3x3 11 10 that that WDT cord-023865-6rafp3x3 11 11 surrounds surround VBZ cord-023865-6rafp3x3 11 12 the the DT cord-023865-6rafp3x3 11 13 genome genome NN cord-023865-6rafp3x3 11 14 ( ( -LRB- cord-023865-6rafp3x3 11 15 either either CC cord-023865-6rafp3x3 11 16 DNA DNA NNP cord-023865-6rafp3x3 11 17 or or CC cord-023865-6rafp3x3 11 18 RNA RNA NNP cord-023865-6rafp3x3 11 19 ) ) -RRB- cord-023865-6rafp3x3 11 20 . . . cord-023865-6rafp3x3 12 1 Nucleocapsid nucleocapsid JJ cord-023865-6rafp3x3 12 2 protein protein NN cord-023865-6rafp3x3 12 3 is be VBZ cord-023865-6rafp3x3 12 4 the the DT cord-023865-6rafp3x3 12 5 major major JJ cord-023865-6rafp3x3 12 6 constituent constituent NN cord-023865-6rafp3x3 12 7 of of IN cord-023865-6rafp3x3 12 8 a a DT cord-023865-6rafp3x3 12 9 viral viral JJ cord-023865-6rafp3x3 12 10 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 12 11 . . . cord-023865-6rafp3x3 13 1 It -PRON- PRP cord-023865-6rafp3x3 13 2 is be VBZ cord-023865-6rafp3x3 13 3 capable capable JJ cord-023865-6rafp3x3 13 4 of of IN cord-023865-6rafp3x3 13 5 associating associate VBG cord-023865-6rafp3x3 13 6 with with IN cord-023865-6rafp3x3 13 7 itself -PRON- PRP cord-023865-6rafp3x3 13 8 and and CC cord-023865-6rafp3x3 13 9 with with IN cord-023865-6rafp3x3 13 10 the the DT cord-023865-6rafp3x3 13 11 genome genome NN cord-023865-6rafp3x3 13 12 , , , cord-023865-6rafp3x3 13 13 thus thus RB cord-023865-6rafp3x3 13 14 packaging package VBG cord-023865-6rafp3x3 13 15 the the DT cord-023865-6rafp3x3 13 16 genome genome NN cord-023865-6rafp3x3 13 17 inside inside IN cord-023865-6rafp3x3 13 18 a a DT cord-023865-6rafp3x3 13 19 closed close VBN cord-023865-6rafp3x3 13 20 cavity cavity NN cord-023865-6rafp3x3 13 21 . . . cord-023865-6rafp3x3 14 1 In in IN cord-023865-6rafp3x3 14 2 some some DT cord-023865-6rafp3x3 14 3 viruses virus NNS cord-023865-6rafp3x3 14 4 , , , cord-023865-6rafp3x3 14 5 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 14 6 protein protein NN cord-023865-6rafp3x3 14 7 may may MD cord-023865-6rafp3x3 14 8 also also RB cord-023865-6rafp3x3 14 9 be be VB cord-023865-6rafp3x3 14 10 assisted assist VBN cord-023865-6rafp3x3 14 11 by by IN cord-023865-6rafp3x3 14 12 other other JJ cord-023865-6rafp3x3 14 13 viral viral JJ cord-023865-6rafp3x3 14 14 cofactors cofactor NNS cord-023865-6rafp3x3 14 15 to to TO cord-023865-6rafp3x3 14 16 form form VB cord-023865-6rafp3x3 14 17 the the DT cord-023865-6rafp3x3 14 18 capsid capsid NN cord-023865-6rafp3x3 14 19 . . . cord-023865-6rafp3x3 15 1 However however RB cord-023865-6rafp3x3 15 2 , , , cord-023865-6rafp3x3 15 3 in in IN cord-023865-6rafp3x3 15 4 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 15 5 ( ( -LRB- cord-023865-6rafp3x3 15 6 including include VBG cord-023865-6rafp3x3 15 7 SARS SARS NNP cord-023865-6rafp3x3 15 8 - - HYPH cord-023865-6rafp3x3 15 9 CoV CoV NNP cord-023865-6rafp3x3 15 10 ) ) -RRB- cord-023865-6rafp3x3 15 11 , , , cord-023865-6rafp3x3 15 12 the the DT cord-023865-6rafp3x3 15 13 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 15 14 protein protein NN cord-023865-6rafp3x3 15 15 alone alone RB cord-023865-6rafp3x3 15 16 is be VBZ cord-023865-6rafp3x3 15 17 capable capable JJ cord-023865-6rafp3x3 15 18 of of IN cord-023865-6rafp3x3 15 19 forming form VBG cord-023865-6rafp3x3 15 20 the the DT cord-023865-6rafp3x3 15 21 capsid capsid NN cord-023865-6rafp3x3 15 22 . . . cord-023865-6rafp3x3 16 1 The the DT cord-023865-6rafp3x3 16 2 primary primary JJ cord-023865-6rafp3x3 16 3 advantage advantage NN cord-023865-6rafp3x3 16 4 of of IN cord-023865-6rafp3x3 16 5 the the DT cord-023865-6rafp3x3 16 6 virus virus NN cord-023865-6rafp3x3 16 7 for for IN cord-023865-6rafp3x3 16 8 encoding encode VBG cord-023865-6rafp3x3 16 9 the the DT cord-023865-6rafp3x3 16 10 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 16 11 protein protein NN cord-023865-6rafp3x3 16 12 is be VBZ cord-023865-6rafp3x3 16 13 that that IN cord-023865-6rafp3x3 16 14 the the DT cord-023865-6rafp3x3 16 15 latter latter JJ cord-023865-6rafp3x3 16 16 encloses enclose VBZ cord-023865-6rafp3x3 16 17 and and CC cord-023865-6rafp3x3 16 18 protects protect VBZ cord-023865-6rafp3x3 16 19 the the DT cord-023865-6rafp3x3 16 20 viral viral JJ cord-023865-6rafp3x3 16 21 genome genome NN cord-023865-6rafp3x3 16 22 from from IN cord-023865-6rafp3x3 16 23 coming come VBG cord-023865-6rafp3x3 16 24 into into IN cord-023865-6rafp3x3 16 25 direct direct JJ cord-023865-6rafp3x3 16 26 contact contact NN cord-023865-6rafp3x3 16 27 with with IN cord-023865-6rafp3x3 16 28 the the DT cord-023865-6rafp3x3 16 29 harsh harsh JJ cord-023865-6rafp3x3 16 30 environment environment NN cord-023865-6rafp3x3 16 31 in in IN cord-023865-6rafp3x3 16 32 the the DT cord-023865-6rafp3x3 16 33 host host NN cord-023865-6rafp3x3 16 34 . . . cord-023865-6rafp3x3 17 1 In in IN cord-023865-6rafp3x3 17 2 fact fact NN cord-023865-6rafp3x3 17 3 , , , cord-023865-6rafp3x3 17 4 in in IN cord-023865-6rafp3x3 17 5 some some DT cord-023865-6rafp3x3 17 6 simple simple JJ cord-023865-6rafp3x3 17 7 viruses virus NNS cord-023865-6rafp3x3 17 8 like like IN cord-023865-6rafp3x3 17 9 hepatitis hepatitis NN cord-023865-6rafp3x3 17 10 E e NN cord-023865-6rafp3x3 17 11 virus virus NN cord-023865-6rafp3x3 17 12 and and CC cord-023865-6rafp3x3 17 13 polio polio NN cord-023865-6rafp3x3 17 14 virus virus NN cord-023865-6rafp3x3 17 15 , , , cord-023865-6rafp3x3 17 16 the the DT cord-023865-6rafp3x3 17 17 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 17 18 protein protein NN cord-023865-6rafp3x3 17 19 is be VBZ cord-023865-6rafp3x3 17 20 the the DT cord-023865-6rafp3x3 17 21 only only JJ cord-023865-6rafp3x3 17 22 coat coat NN cord-023865-6rafp3x3 17 23 that that WDT cord-023865-6rafp3x3 17 24 protects protect VBZ cord-023865-6rafp3x3 17 25 the the DT cord-023865-6rafp3x3 17 26 genome genome NN cord-023865-6rafp3x3 17 27 from from IN cord-023865-6rafp3x3 17 28 the the DT cord-023865-6rafp3x3 17 29 outside outside JJ cord-023865-6rafp3x3 17 30 world world NN cord-023865-6rafp3x3 17 31 . . . cord-023865-6rafp3x3 18 1 However however RB cord-023865-6rafp3x3 18 2 , , , cord-023865-6rafp3x3 18 3 in in IN cord-023865-6rafp3x3 18 4 complex complex JJ cord-023865-6rafp3x3 18 5 viruses virus NNS cord-023865-6rafp3x3 18 6 , , , cord-023865-6rafp3x3 18 7 like like IN cord-023865-6rafp3x3 18 8 hepatitis hepatitis NN cord-023865-6rafp3x3 18 9 B B NNP cord-023865-6rafp3x3 18 10 virus virus NN cord-023865-6rafp3x3 18 11 and and CC cord-023865-6rafp3x3 18 12 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 18 13 ( ( -LRB- cord-023865-6rafp3x3 18 14 including include VBG cord-023865-6rafp3x3 18 15 SARS SARS NNP cord-023865-6rafp3x3 18 16 - - HYPH cord-023865-6rafp3x3 18 17 CoV CoV NNP cord-023865-6rafp3x3 18 18 ) ) -RRB- cord-023865-6rafp3x3 18 19 , , , cord-023865-6rafp3x3 18 20 the the DT cord-023865-6rafp3x3 18 21 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 18 22 is be VBZ cord-023865-6rafp3x3 18 23 covered cover VBN cord-023865-6rafp3x3 18 24 by by IN cord-023865-6rafp3x3 18 25 an an DT cord-023865-6rafp3x3 18 26 additional additional JJ cord-023865-6rafp3x3 18 27 coat coat NN cord-023865-6rafp3x3 18 28 composed compose VBN cord-023865-6rafp3x3 18 29 of of IN cord-023865-6rafp3x3 18 30 other other JJ cord-023865-6rafp3x3 18 31 viral viral JJ cord-023865-6rafp3x3 18 32 proteins protein NNS cord-023865-6rafp3x3 18 33 ( ( -LRB- cord-023865-6rafp3x3 18 34 spike spike NN cord-023865-6rafp3x3 18 35 protein protein NN cord-023865-6rafp3x3 18 36 is be VBZ cord-023865-6rafp3x3 18 37 a a DT cord-023865-6rafp3x3 18 38 major major JJ cord-023865-6rafp3x3 18 39 component component NN cord-023865-6rafp3x3 18 40 of of IN cord-023865-6rafp3x3 18 41 this this DT cord-023865-6rafp3x3 18 42 coat coat NN cord-023865-6rafp3x3 18 43 ) ) -RRB- cord-023865-6rafp3x3 18 44 . . . cord-023865-6rafp3x3 19 1 Besides besides IN cord-023865-6rafp3x3 19 2 this this DT cord-023865-6rafp3x3 19 3 property property NN cord-023865-6rafp3x3 19 4 , , , cord-023865-6rafp3x3 19 5 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 19 6 proteins protein NNS cord-023865-6rafp3x3 19 7 of of IN cord-023865-6rafp3x3 19 8 several several JJ cord-023865-6rafp3x3 19 9 viruses virus NNS cord-023865-6rafp3x3 19 10 have have VBP cord-023865-6rafp3x3 19 11 been be VBN cord-023865-6rafp3x3 19 12 demonstrated demonstrate VBN cord-023865-6rafp3x3 19 13 to to TO cord-023865-6rafp3x3 19 14 play play VB cord-023865-6rafp3x3 19 15 multiple multiple JJ cord-023865-6rafp3x3 19 16 regulatory regulatory JJ cord-023865-6rafp3x3 19 17 roles role NNS cord-023865-6rafp3x3 19 18 during during IN cord-023865-6rafp3x3 19 19 viral viral JJ cord-023865-6rafp3x3 19 20 pathogenesis pathogenesis NN cord-023865-6rafp3x3 19 21 . . . cord-023865-6rafp3x3 20 1 They -PRON- PRP cord-023865-6rafp3x3 20 2 are be VBP cord-023865-6rafp3x3 20 3 equipped equip VBN cord-023865-6rafp3x3 20 4 with with IN cord-023865-6rafp3x3 20 5 specific specific JJ cord-023865-6rafp3x3 20 6 structural structural JJ cord-023865-6rafp3x3 20 7 motifs motif NNS cord-023865-6rafp3x3 20 8 and/or and/or CC cord-023865-6rafp3x3 20 9 signature signature NN cord-023865-6rafp3x3 20 10 sequences sequence NNS cord-023865-6rafp3x3 20 11 , , , cord-023865-6rafp3x3 20 12 by by IN cord-023865-6rafp3x3 20 13 which which WDT cord-023865-6rafp3x3 20 14 they -PRON- PRP cord-023865-6rafp3x3 20 15 associate associate VBP cord-023865-6rafp3x3 20 16 with with IN cord-023865-6rafp3x3 20 17 other other JJ cord-023865-6rafp3x3 20 18 viral/ viral/ NNP cord-023865-6rafp3x3 20 19 host host NN cord-023865-6rafp3x3 20 20 factors factor NNS cord-023865-6rafp3x3 20 21 and and CC cord-023865-6rafp3x3 20 22 skew skew VB cord-023865-6rafp3x3 20 23 the the DT cord-023865-6rafp3x3 20 24 host host NN cord-023865-6rafp3x3 20 25 cellular cellular JJ cord-023865-6rafp3x3 20 26 machinery machinery NN cord-023865-6rafp3x3 20 27 in in IN cord-023865-6rafp3x3 20 28 such such PDT cord-023865-6rafp3x3 20 29 a a DT cord-023865-6rafp3x3 20 30 manner manner NN cord-023865-6rafp3x3 20 31 that that IN cord-023865-6rafp3x3 20 32 it -PRON- PRP cord-023865-6rafp3x3 20 33 becomes become VBZ cord-023865-6rafp3x3 20 34 more more RBR cord-023865-6rafp3x3 20 35 favorable favorable JJ cord-023865-6rafp3x3 20 36 for for IN cord-023865-6rafp3x3 20 37 the the DT cord-023865-6rafp3x3 20 38 survival survival NN cord-023865-6rafp3x3 20 39 of of IN cord-023865-6rafp3x3 20 40 the the DT cord-023865-6rafp3x3 20 41 virus virus NN cord-023865-6rafp3x3 20 42 . . . cord-023865-6rafp3x3 21 1 Nucleocapsid nucleocapsid JJ cord-023865-6rafp3x3 21 2 protein protein NN cord-023865-6rafp3x3 21 3 is be VBZ cord-023865-6rafp3x3 21 4 also also RB cord-023865-6rafp3x3 21 5 one one CD cord-023865-6rafp3x3 21 6 of of IN cord-023865-6rafp3x3 21 7 the the DT cord-023865-6rafp3x3 21 8 most most RBS cord-023865-6rafp3x3 21 9 abundantly abundantly RB cord-023865-6rafp3x3 21 10 expressed express VBN cord-023865-6rafp3x3 21 11 viral viral JJ cord-023865-6rafp3x3 21 12 proteins protein NNS cord-023865-6rafp3x3 21 13 and and CC cord-023865-6rafp3x3 21 14 it -PRON- PRP cord-023865-6rafp3x3 21 15 is be VBZ cord-023865-6rafp3x3 21 16 the the DT cord-023865-6rafp3x3 21 17 major major JJ cord-023865-6rafp3x3 21 18 antigen antigen NN cord-023865-6rafp3x3 21 19 recognized recognize VBN cord-023865-6rafp3x3 21 20 by by IN cord-023865-6rafp3x3 21 21 convalescent convalescent JJ cord-023865-6rafp3x3 21 22 antisera antisera NN cord-023865-6rafp3x3 21 23 . . . cord-023865-6rafp3x3 22 1 Hence hence RB cord-023865-6rafp3x3 22 2 , , , cord-023865-6rafp3x3 22 3 it -PRON- PRP cord-023865-6rafp3x3 22 4 is be VBZ cord-023865-6rafp3x3 22 5 tempting tempt VBG cord-023865-6rafp3x3 22 6 to to TO cord-023865-6rafp3x3 22 7 evaluate evaluate VB cord-023865-6rafp3x3 22 8 its -PRON- PRP$ cord-023865-6rafp3x3 22 9 potential potential NN cord-023865-6rafp3x3 22 10 as as IN cord-023865-6rafp3x3 22 11 a a DT cord-023865-6rafp3x3 22 12 candidate candidate NN cord-023865-6rafp3x3 22 13 diagnostic diagnostic JJ cord-023865-6rafp3x3 22 14 tool tool NN cord-023865-6rafp3x3 22 15 or or CC cord-023865-6rafp3x3 22 16 vaccine vaccine NN cord-023865-6rafp3x3 22 17 against against IN cord-023865-6rafp3x3 22 18 the the DT cord-023865-6rafp3x3 22 19 virus virus NN cord-023865-6rafp3x3 22 20 . . . cord-023865-6rafp3x3 23 1 Therefore therefore RB cord-023865-6rafp3x3 23 2 , , , cord-023865-6rafp3x3 23 3 understanding understand VBG cord-023865-6rafp3x3 23 4 the the DT cord-023865-6rafp3x3 23 5 properties property NNS cord-023865-6rafp3x3 23 6 of of IN cord-023865-6rafp3x3 23 7 the the DT cord-023865-6rafp3x3 23 8 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 23 9 protein protein NN cord-023865-6rafp3x3 23 10 is be VBZ cord-023865-6rafp3x3 23 11 of of IN cord-023865-6rafp3x3 23 12 utmost utmost JJ cord-023865-6rafp3x3 23 13 importance importance NN cord-023865-6rafp3x3 23 14 to to IN cord-023865-6rafp3x3 23 15 any any DT cord-023865-6rafp3x3 23 16 virologist virologist NN cord-023865-6rafp3x3 23 17 in in IN cord-023865-6rafp3x3 23 18 order order NN cord-023865-6rafp3x3 23 19 to to TO cord-023865-6rafp3x3 23 20 understand understand VB cord-023865-6rafp3x3 23 21 the the DT cord-023865-6rafp3x3 23 22 biology biology NN cord-023865-6rafp3x3 23 23 of of IN cord-023865-6rafp3x3 23 24 the the DT cord-023865-6rafp3x3 23 25 virus virus NN cord-023865-6rafp3x3 23 26 and and CC cord-023865-6rafp3x3 23 27 develop develop VB cord-023865-6rafp3x3 23 28 effective effective JJ cord-023865-6rafp3x3 23 29 tools tool NNS cord-023865-6rafp3x3 23 30 to to TO cord-023865-6rafp3x3 23 31 control control VB cord-023865-6rafp3x3 23 32 the the DT cord-023865-6rafp3x3 23 33 infection infection NN cord-023865-6rafp3x3 23 34 . . . cord-023865-6rafp3x3 24 1 Since since IN cord-023865-6rafp3x3 24 2 the the DT cord-023865-6rafp3x3 24 3 identification identification NN cord-023865-6rafp3x3 24 4 and and CC cord-023865-6rafp3x3 24 5 isolation isolation NN cord-023865-6rafp3x3 24 6 of of IN cord-023865-6rafp3x3 24 7 SARS SARS NNP cord-023865-6rafp3x3 24 8 - - HYPH cord-023865-6rafp3x3 24 9 CoV CoV NNP cord-023865-6rafp3x3 24 10 in in IN cord-023865-6rafp3x3 24 11 2003 2003 CD cord-023865-6rafp3x3 24 12 , , , cord-023865-6rafp3x3 24 13 several several JJ cord-023865-6rafp3x3 24 14 laboratories laboratory NNS cord-023865-6rafp3x3 24 15 around around IN cord-023865-6rafp3x3 24 16 the the DT cord-023865-6rafp3x3 24 17 world world NN cord-023865-6rafp3x3 24 18 have have VBP cord-023865-6rafp3x3 24 19 focussed focusse VBN cord-023865-6rafp3x3 24 20 their -PRON- PRP$ cord-023865-6rafp3x3 24 21 research research NN cord-023865-6rafp3x3 24 22 on on IN cord-023865-6rafp3x3 24 23 characterization characterization NN cord-023865-6rafp3x3 24 24 of of IN cord-023865-6rafp3x3 24 25 various various JJ cord-023865-6rafp3x3 24 26 properties property NNS cord-023865-6rafp3x3 24 27 of of IN cord-023865-6rafp3x3 24 28 the the DT cord-023865-6rafp3x3 24 29 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 24 30 protein protein NN cord-023865-6rafp3x3 24 31 . . . cord-023865-6rafp3x3 25 1 An an DT cord-023865-6rafp3x3 25 2 indirect indirect JJ cord-023865-6rafp3x3 25 3 measure measure NN cord-023865-6rafp3x3 25 4 of of IN cord-023865-6rafp3x3 25 5 the the DT cord-023865-6rafp3x3 25 6 curiosity curiosity NN cord-023865-6rafp3x3 25 7 among among IN cord-023865-6rafp3x3 25 8 SARS SARS NNP cord-023865-6rafp3x3 25 9 - - HYPH cord-023865-6rafp3x3 25 10 CoV cov NN cord-023865-6rafp3x3 25 11 researchers researcher NNS cord-023865-6rafp3x3 25 12 to to TO cord-023865-6rafp3x3 25 13 study study VB cord-023865-6rafp3x3 25 14 the the DT cord-023865-6rafp3x3 25 15 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 25 16 protein protein NN cord-023865-6rafp3x3 25 17 is be VBZ cord-023865-6rafp3x3 25 18 revealed reveal VBN cord-023865-6rafp3x3 25 19 from from IN cord-023865-6rafp3x3 25 20 the the DT cord-023865-6rafp3x3 25 21 fact fact NN cord-023865-6rafp3x3 25 22 that that IN cord-023865-6rafp3x3 25 23 in in IN cord-023865-6rafp3x3 25 24 PubMed PubMed NNP cord-023865-6rafp3x3 25 25 the the DT cord-023865-6rafp3x3 25 26 number number NN cord-023865-6rafp3x3 25 27 of of IN cord-023865-6rafp3x3 25 28 SARS SARS NNP cord-023865-6rafp3x3 25 29 - - HYPH cord-023865-6rafp3x3 25 30 CoV CoV NNP cord-023865-6rafp3x3 25 31 research research NN cord-023865-6rafp3x3 25 32 publications publication NNS cord-023865-6rafp3x3 25 33 focussed focusse VBN cord-023865-6rafp3x3 25 34 on on IN cord-023865-6rafp3x3 25 35 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 25 36 protein protein NN cord-023865-6rafp3x3 25 37 is be VBZ cord-023865-6rafp3x3 25 38 second second JJ cord-023865-6rafp3x3 25 39 only only RB cord-023865-6rafp3x3 25 40 to to IN cord-023865-6rafp3x3 25 41 those those DT cord-023865-6rafp3x3 25 42 on on IN cord-023865-6rafp3x3 25 43 spike spike NN cord-023865-6rafp3x3 25 44 protein protein NN cord-023865-6rafp3x3 25 45 . . . cord-023865-6rafp3x3 26 1 Evidence evidence NN cord-023865-6rafp3x3 26 2 accumulated accumulate VBN cord-023865-6rafp3x3 26 3 from from IN cord-023865-6rafp3x3 26 4 these these DT cord-023865-6rafp3x3 26 5 articles article NNS cord-023865-6rafp3x3 26 6 has have VBZ cord-023865-6rafp3x3 26 7 helped help VBN cord-023865-6rafp3x3 26 8 us -PRON- PRP cord-023865-6rafp3x3 26 9 gain gain VB cord-023865-6rafp3x3 26 10 substantial substantial JJ cord-023865-6rafp3x3 26 11 understanding understanding NN cord-023865-6rafp3x3 26 12 of of IN cord-023865-6rafp3x3 26 13 the the DT cord-023865-6rafp3x3 26 14 properties property NNS cord-023865-6rafp3x3 26 15 of of IN cord-023865-6rafp3x3 26 16 this this DT cord-023865-6rafp3x3 26 17 protein protein NN cord-023865-6rafp3x3 26 18 . . . cord-023865-6rafp3x3 27 1 In in IN cord-023865-6rafp3x3 27 2 this this DT cord-023865-6rafp3x3 27 3 article article NN cord-023865-6rafp3x3 27 4 , , , cord-023865-6rafp3x3 27 5 we -PRON- PRP cord-023865-6rafp3x3 27 6 will will MD cord-023865-6rafp3x3 27 7 provide provide VB cord-023865-6rafp3x3 27 8 a a DT cord-023865-6rafp3x3 27 9 comprehensive comprehensive JJ cord-023865-6rafp3x3 27 10 description description NN cord-023865-6rafp3x3 27 11 of of IN cord-023865-6rafp3x3 27 12 all all PDT cord-023865-6rafp3x3 27 13 the the DT cord-023865-6rafp3x3 27 14 different different JJ cord-023865-6rafp3x3 27 15 properties property NNS cord-023865-6rafp3x3 27 16 of of IN cord-023865-6rafp3x3 27 17 the the DT cord-023865-6rafp3x3 27 18 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 27 19 protein protein NN cord-023865-6rafp3x3 27 20 , , , cord-023865-6rafp3x3 27 21 as as IN cord-023865-6rafp3x3 27 22 established establish VBN cord-023865-6rafp3x3 27 23 by by IN cord-023865-6rafp3x3 27 24 independent independent JJ cord-023865-6rafp3x3 27 25 workers worker NNS cord-023865-6rafp3x3 27 26 from from IN cord-023865-6rafp3x3 27 27 several several JJ cord-023865-6rafp3x3 27 28 laboratories laboratory NNS cord-023865-6rafp3x3 27 29 . . . cord-023865-6rafp3x3 28 1 We -PRON- PRP cord-023865-6rafp3x3 28 2 will will MD cord-023865-6rafp3x3 28 3 conclude conclude VB cord-023865-6rafp3x3 28 4 this this DT cord-023865-6rafp3x3 28 5 article article NN cord-023865-6rafp3x3 28 6 with with IN cord-023865-6rafp3x3 28 7 the the DT cord-023865-6rafp3x3 28 8 discussion discussion NN cord-023865-6rafp3x3 28 9 of of IN cord-023865-6rafp3x3 28 10 some some DT cord-023865-6rafp3x3 28 11 of of IN cord-023865-6rafp3x3 28 12 the the DT cord-023865-6rafp3x3 28 13 remaining remain VBG cord-023865-6rafp3x3 28 14 challenges challenge NNS cord-023865-6rafp3x3 28 15 in in IN cord-023865-6rafp3x3 28 16 this this DT cord-023865-6rafp3x3 28 17 field field NN cord-023865-6rafp3x3 28 18 that that WDT cord-023865-6rafp3x3 28 19 need need VBP cord-023865-6rafp3x3 28 20 to to TO cord-023865-6rafp3x3 28 21 be be VB cord-023865-6rafp3x3 28 22 addressed address VBN cord-023865-6rafp3x3 28 23 in in IN cord-023865-6rafp3x3 28 24 future future NN cord-023865-6rafp3x3 28 25 . . . cord-023865-6rafp3x3 29 1 The the DT cord-023865-6rafp3x3 29 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 29 3 ( ( -LRB- cord-023865-6rafp3x3 29 4 N N NNP cord-023865-6rafp3x3 29 5 ) ) -RRB- cord-023865-6rafp3x3 29 6 protein protein NN cord-023865-6rafp3x3 29 7 is be VBZ cord-023865-6rafp3x3 29 8 encoded encode VBN cord-023865-6rafp3x3 29 9 by by IN cord-023865-6rafp3x3 29 10 the the DT cord-023865-6rafp3x3 29 11 ninth ninth JJ cord-023865-6rafp3x3 29 12 ORF ORF NNP cord-023865-6rafp3x3 29 13 of of IN cord-023865-6rafp3x3 29 14 SARS SARS NNP cord-023865-6rafp3x3 30 1 -CoV. -cov. ADD cord-023865-6rafp3x3 31 1 The the DT cord-023865-6rafp3x3 31 2 same same JJ cord-023865-6rafp3x3 31 3 ORF ORF NNP cord-023865-6rafp3x3 31 4 also also RB cord-023865-6rafp3x3 31 5 codes code VBZ cord-023865-6rafp3x3 31 6 for for IN cord-023865-6rafp3x3 31 7 another another DT cord-023865-6rafp3x3 31 8 unique unique JJ cord-023865-6rafp3x3 31 9 accessory accessory NN cord-023865-6rafp3x3 31 10 protein protein NN cord-023865-6rafp3x3 31 11 called call VBN cord-023865-6rafp3x3 31 12 ORF9b ORF9b NNP cord-023865-6rafp3x3 31 13 , , , cord-023865-6rafp3x3 31 14 though though IN cord-023865-6rafp3x3 31 15 in in IN cord-023865-6rafp3x3 31 16 a a DT cord-023865-6rafp3x3 31 17 different different JJ cord-023865-6rafp3x3 31 18 reading reading NN cord-023865-6rafp3x3 31 19 frame frame NN cord-023865-6rafp3x3 31 20 , , , cord-023865-6rafp3x3 31 21 whose whose WP$ cord-023865-6rafp3x3 31 22 function function NN cord-023865-6rafp3x3 31 23 is be VBZ cord-023865-6rafp3x3 31 24 yet yet RB cord-023865-6rafp3x3 31 25 to to TO cord-023865-6rafp3x3 31 26 be be VB cord-023865-6rafp3x3 31 27 defined define VBN cord-023865-6rafp3x3 31 28 . . . cord-023865-6rafp3x3 32 1 The the DT cord-023865-6rafp3x3 32 2 N N NNP cord-023865-6rafp3x3 32 3 - - HYPH cord-023865-6rafp3x3 32 4 protein protein NN cord-023865-6rafp3x3 32 5 is be VBZ cord-023865-6rafp3x3 32 6 a a DT cord-023865-6rafp3x3 32 7 46-kDa 46-kda CD cord-023865-6rafp3x3 32 8 protein protein NN cord-023865-6rafp3x3 32 9 composed compose VBN cord-023865-6rafp3x3 32 10 of of IN cord-023865-6rafp3x3 32 11 422 422 CD cord-023865-6rafp3x3 32 12 amino amino JJ cord-023865-6rafp3x3 32 13 acids acid NNS cord-023865-6rafp3x3 32 14 ( ( -LRB- cord-023865-6rafp3x3 32 15 Rota Rota NNP cord-023865-6rafp3x3 32 16 et et NNP cord-023865-6rafp3x3 32 17 al al NNP cord-023865-6rafp3x3 32 18 . . NNP cord-023865-6rafp3x3 32 19 2003 2003 CD cord-023865-6rafp3x3 32 20 ) ) -RRB- cord-023865-6rafp3x3 32 21 . . . cord-023865-6rafp3x3 33 1 Its -PRON- PRP$ cord-023865-6rafp3x3 33 2 N n CD cord-023865-6rafp3x3 33 3 - - HYPH cord-023865-6rafp3x3 33 4 terminal terminal NN cord-023865-6rafp3x3 33 5 region region NN cord-023865-6rafp3x3 33 6 consists consist VBZ cord-023865-6rafp3x3 33 7 mostly mostly RB cord-023865-6rafp3x3 33 8 of of IN cord-023865-6rafp3x3 33 9 positively positively RB cord-023865-6rafp3x3 33 10 charged charge VBN cord-023865-6rafp3x3 33 11 amino amino NN cord-023865-6rafp3x3 33 12 acids acid NNS cord-023865-6rafp3x3 33 13 , , , cord-023865-6rafp3x3 33 14 which which WDT cord-023865-6rafp3x3 33 15 are be VBP cord-023865-6rafp3x3 33 16 responsible responsible JJ cord-023865-6rafp3x3 33 17 for for IN cord-023865-6rafp3x3 33 18 RNA RNA NNP cord-023865-6rafp3x3 33 19 binding binding NN cord-023865-6rafp3x3 33 20 . . . cord-023865-6rafp3x3 34 1 A a DT cord-023865-6rafp3x3 34 2 lysine lysine NN cord-023865-6rafp3x3 34 3 - - HYPH cord-023865-6rafp3x3 34 4 rich rich JJ cord-023865-6rafp3x3 34 5 region region NN cord-023865-6rafp3x3 34 6 is be VBZ cord-023865-6rafp3x3 34 7 present present JJ cord-023865-6rafp3x3 34 8 between between IN cord-023865-6rafp3x3 34 9 amino amino NN cord-023865-6rafp3x3 34 10 acids acid NNS cord-023865-6rafp3x3 34 11 373 373 CD cord-023865-6rafp3x3 34 12 and and CC cord-023865-6rafp3x3 34 13 390 390 CD cord-023865-6rafp3x3 34 14 at at IN cord-023865-6rafp3x3 34 15 the the DT cord-023865-6rafp3x3 34 16 C C NNP cord-023865-6rafp3x3 34 17 - - HYPH cord-023865-6rafp3x3 34 18 terminus terminus NN cord-023865-6rafp3x3 34 19 , , , cord-023865-6rafp3x3 34 20 which which WDT cord-023865-6rafp3x3 34 21 is be VBZ cord-023865-6rafp3x3 34 22 predicted predict VBN cord-023865-6rafp3x3 34 23 to to TO cord-023865-6rafp3x3 34 24 be be VB cord-023865-6rafp3x3 34 25 the the DT cord-023865-6rafp3x3 34 26 nuclear nuclear JJ cord-023865-6rafp3x3 34 27 localization localization NN cord-023865-6rafp3x3 34 28 signal signal NN cord-023865-6rafp3x3 34 29 . . . cord-023865-6rafp3x3 35 1 Besides besides IN cord-023865-6rafp3x3 35 2 these these DT cord-023865-6rafp3x3 35 3 , , , cord-023865-6rafp3x3 35 4 an an DT cord-023865-6rafp3x3 35 5 SR SR NNP cord-023865-6rafp3x3 35 6 - - HYPH cord-023865-6rafp3x3 35 7 rich rich JJ cord-023865-6rafp3x3 35 8 motif motif NN cord-023865-6rafp3x3 35 9 is be VBZ cord-023865-6rafp3x3 35 10 present present JJ cord-023865-6rafp3x3 35 11 in in IN cord-023865-6rafp3x3 35 12 the the DT cord-023865-6rafp3x3 35 13 middle middle JJ cord-023865-6rafp3x3 35 14 region region NN cord-023865-6rafp3x3 35 15 encompassing encompass VBG cord-023865-6rafp3x3 35 16 amino amino NN cord-023865-6rafp3x3 35 17 acids acid NNS cord-023865-6rafp3x3 35 18 177 177 CD cord-023865-6rafp3x3 35 19 - - SYM cord-023865-6rafp3x3 35 20 207 207 CD cord-023865-6rafp3x3 35 21 . . . cord-023865-6rafp3x3 36 1 Biophysical biophysical JJ cord-023865-6rafp3x3 36 2 studies study NNS cord-023865-6rafp3x3 36 3 done do VBN cord-023865-6rafp3x3 36 4 by by IN cord-023865-6rafp3x3 36 5 Chang Chang NNP cord-023865-6rafp3x3 36 6 et et NNP cord-023865-6rafp3x3 36 7 al al NNP cord-023865-6rafp3x3 36 8 . . . cord-023865-6rafp3x3 37 1 ( ( -LRB- cord-023865-6rafp3x3 37 2 2006 2006 CD cord-023865-6rafp3x3 37 3 ) ) -RRB- cord-023865-6rafp3x3 37 4 have have VBP cord-023865-6rafp3x3 37 5 suggested suggest VBN cord-023865-6rafp3x3 37 6 that that IN cord-023865-6rafp3x3 37 7 this this DT cord-023865-6rafp3x3 37 8 protein protein NN cord-023865-6rafp3x3 37 9 is be VBZ cord-023865-6rafp3x3 37 10 composed compose VBN cord-023865-6rafp3x3 37 11 of of IN cord-023865-6rafp3x3 37 12 two two CD cord-023865-6rafp3x3 37 13 independent independent JJ cord-023865-6rafp3x3 37 14 structural structural JJ cord-023865-6rafp3x3 37 15 domains domain NNS cord-023865-6rafp3x3 37 16 and and CC cord-023865-6rafp3x3 37 17 a a DT cord-023865-6rafp3x3 37 18 linker linker NN cord-023865-6rafp3x3 37 19 region region NN cord-023865-6rafp3x3 37 20 . . . cord-023865-6rafp3x3 38 1 The the DT cord-023865-6rafp3x3 38 2 first first JJ cord-023865-6rafp3x3 38 3 domain domain NN cord-023865-6rafp3x3 38 4 is be VBZ cord-023865-6rafp3x3 38 5 present present JJ cord-023865-6rafp3x3 38 6 at at IN cord-023865-6rafp3x3 38 7 the the DT cord-023865-6rafp3x3 38 8 N n CD cord-023865-6rafp3x3 38 9 - - HYPH cord-023865-6rafp3x3 38 10 terminus terminus NN cord-023865-6rafp3x3 38 11 , , , cord-023865-6rafp3x3 38 12 inside inside IN cord-023865-6rafp3x3 38 13 the the DT cord-023865-6rafp3x3 38 14 putative putative JJ cord-023865-6rafp3x3 38 15 RNA RNA NNP cord-023865-6rafp3x3 38 16 binding binding NN cord-023865-6rafp3x3 38 17 domain domain NN cord-023865-6rafp3x3 38 18 , , , cord-023865-6rafp3x3 38 19 and and CC cord-023865-6rafp3x3 38 20 the the DT cord-023865-6rafp3x3 38 21 second second JJ cord-023865-6rafp3x3 38 22 domain domain NN cord-023865-6rafp3x3 38 23 consists consist VBZ cord-023865-6rafp3x3 38 24 of of IN cord-023865-6rafp3x3 38 25 the the DT cord-023865-6rafp3x3 38 26 C C NNP cord-023865-6rafp3x3 38 27 - - HYPH cord-023865-6rafp3x3 38 28 terminal terminal NN cord-023865-6rafp3x3 38 29 region region NN cord-023865-6rafp3x3 38 30 that that WDT cord-023865-6rafp3x3 38 31 is be VBZ cord-023865-6rafp3x3 38 32 capable capable JJ cord-023865-6rafp3x3 38 33 of of IN cord-023865-6rafp3x3 38 34 selfassociation selfassociation NN cord-023865-6rafp3x3 38 35 . . . cord-023865-6rafp3x3 39 1 Between between IN cord-023865-6rafp3x3 39 2 these these DT cord-023865-6rafp3x3 39 3 two two CD cord-023865-6rafp3x3 39 4 structural structural JJ cord-023865-6rafp3x3 39 5 domains domain NNS cord-023865-6rafp3x3 39 6 , , , cord-023865-6rafp3x3 39 7 there there EX cord-023865-6rafp3x3 39 8 lies lie VBZ cord-023865-6rafp3x3 39 9 a a DT cord-023865-6rafp3x3 39 10 highly highly RB cord-023865-6rafp3x3 39 11 disordered disordered JJ cord-023865-6rafp3x3 39 12 region region NN cord-023865-6rafp3x3 39 13 , , , cord-023865-6rafp3x3 39 14 which which WDT cord-023865-6rafp3x3 39 15 serves serve VBZ cord-023865-6rafp3x3 39 16 as as IN cord-023865-6rafp3x3 39 17 a a DT cord-023865-6rafp3x3 39 18 linker linker NN cord-023865-6rafp3x3 39 19 . . . cord-023865-6rafp3x3 40 1 This this DT cord-023865-6rafp3x3 40 2 region region NN cord-023865-6rafp3x3 40 3 has have VBZ cord-023865-6rafp3x3 40 4 been be VBN cord-023865-6rafp3x3 40 5 reported report VBN cord-023865-6rafp3x3 40 6 to to TO cord-023865-6rafp3x3 40 7 interact interact VB cord-023865-6rafp3x3 40 8 with with IN cord-023865-6rafp3x3 40 9 the the DT cord-023865-6rafp3x3 40 10 membrane membrane NN cord-023865-6rafp3x3 40 11 ( ( -LRB- cord-023865-6rafp3x3 40 12 M M NNP cord-023865-6rafp3x3 40 13 ) ) -RRB- cord-023865-6rafp3x3 40 14 protein protein NN cord-023865-6rafp3x3 40 15 and and CC cord-023865-6rafp3x3 40 16 human human JJ cord-023865-6rafp3x3 40 17 cellular cellular NN cord-023865-6rafp3x3 40 18 hnRNPA1 hnRNPA1 NNP cord-023865-6rafp3x3 40 19 protein protein NN cord-023865-6rafp3x3 41 1 ( ( -LRB- cord-023865-6rafp3x3 41 2 Fang Fang NNP cord-023865-6rafp3x3 41 3 et et FW cord-023865-6rafp3x3 41 4 al al NNP cord-023865-6rafp3x3 41 5 . . . cord-023865-6rafp3x3 42 1 2006 2006 CD cord-023865-6rafp3x3 42 2 ; ; : cord-023865-6rafp3x3 42 3 Luo Luo NNP cord-023865-6rafp3x3 42 4 et et NNP cord-023865-6rafp3x3 42 5 al al NNP cord-023865-6rafp3x3 42 6 . . NNP cord-023865-6rafp3x3 42 7 2005 2005 CD cord-023865-6rafp3x3 42 8 ) ) -RRB- cord-023865-6rafp3x3 42 9 . . . cord-023865-6rafp3x3 43 1 Besides besides RB cord-023865-6rafp3x3 43 2 , , , cord-023865-6rafp3x3 43 3 this this DT cord-023865-6rafp3x3 43 4 region region NN cord-023865-6rafp3x3 43 5 is be VBZ cord-023865-6rafp3x3 43 6 also also RB cord-023865-6rafp3x3 43 7 predicted predict VBN cord-023865-6rafp3x3 43 8 to to TO cord-023865-6rafp3x3 43 9 be be VB cord-023865-6rafp3x3 43 10 a a DT cord-023865-6rafp3x3 43 11 hot hot JJ cord-023865-6rafp3x3 43 12 spot spot NN cord-023865-6rafp3x3 43 13 for for IN cord-023865-6rafp3x3 43 14 phosphorylation phosphorylation NN cord-023865-6rafp3x3 43 15 . . . cord-023865-6rafp3x3 44 1 Hence hence RB cord-023865-6rafp3x3 44 2 , , , cord-023865-6rafp3x3 44 3 in in IN cord-023865-6rafp3x3 44 4 summary summary NN cord-023865-6rafp3x3 44 5 , , , cord-023865-6rafp3x3 44 6 the the DT cord-023865-6rafp3x3 44 7 N n NN cord-023865-6rafp3x3 44 8 - - HYPH cord-023865-6rafp3x3 44 9 protein protein NN cord-023865-6rafp3x3 44 10 can can MD cord-023865-6rafp3x3 44 11 be be VB cord-023865-6rafp3x3 44 12 classified classify VBN cord-023865-6rafp3x3 44 13 into into IN cord-023865-6rafp3x3 44 14 three three CD cord-023865-6rafp3x3 44 15 distinct distinct JJ cord-023865-6rafp3x3 44 16 regions region NNS cord-023865-6rafp3x3 44 17 ( ( -LRB- cord-023865-6rafp3x3 44 18 Fig fig NN cord-023865-6rafp3x3 44 19 . . . cord-023865-6rafp3x3 44 20 9 9 CD cord-023865-6rafp3x3 44 21 .1 .1 CD cord-023865-6rafp3x3 44 22 ) ) -RRB- cord-023865-6rafp3x3 44 23 , , , cord-023865-6rafp3x3 44 24 which which WDT cord-023865-6rafp3x3 44 25 may may MD cord-023865-6rafp3x3 44 26 serve serve VB cord-023865-6rafp3x3 44 27 completely completely RB cord-023865-6rafp3x3 44 28 different different JJ cord-023865-6rafp3x3 44 29 functions function NNS cord-023865-6rafp3x3 44 30 during during IN cord-023865-6rafp3x3 44 31 different different JJ cord-023865-6rafp3x3 44 32 stages stage NNS cord-023865-6rafp3x3 44 33 of of IN cord-023865-6rafp3x3 44 34 the the DT cord-023865-6rafp3x3 44 35 viral viral JJ cord-023865-6rafp3x3 44 36 life life NN cord-023865-6rafp3x3 44 37 - - HYPH cord-023865-6rafp3x3 44 38 cycle cycle NN cord-023865-6rafp3x3 44 39 . . . cord-023865-6rafp3x3 45 1 A a DT cord-023865-6rafp3x3 45 2 similar similar JJ cord-023865-6rafp3x3 45 3 mode mode NN cord-023865-6rafp3x3 45 4 of of IN cord-023865-6rafp3x3 45 5 organization organization NN cord-023865-6rafp3x3 45 6 has have VBZ cord-023865-6rafp3x3 45 7 been be VBN cord-023865-6rafp3x3 45 8 reported report VBN cord-023865-6rafp3x3 45 9 for for IN cord-023865-6rafp3x3 45 10 other other JJ cord-023865-6rafp3x3 45 11 coronavirus coronavirus NN cord-023865-6rafp3x3 45 12 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 45 13 proteins protein NNS cord-023865-6rafp3x3 45 14 . . . cord-023865-6rafp3x3 46 1 In in IN cord-023865-6rafp3x3 46 2 - - HYPH cord-023865-6rafp3x3 46 3 vitro vitro FW cord-023865-6rafp3x3 46 4 thermodynamic thermodynamic JJ cord-023865-6rafp3x3 46 5 studies study NNS cord-023865-6rafp3x3 46 6 done do VBN cord-023865-6rafp3x3 46 7 by by IN cord-023865-6rafp3x3 46 8 Luo Luo NNP cord-023865-6rafp3x3 46 9 et et NNP cord-023865-6rafp3x3 46 10 al al NNP cord-023865-6rafp3x3 46 11 . . . cord-023865-6rafp3x3 47 1 ( ( -LRB- cord-023865-6rafp3x3 47 2 2004b 2004b CD cord-023865-6rafp3x3 47 3 ) ) -RRB- cord-023865-6rafp3x3 47 4 using use VBG cord-023865-6rafp3x3 47 5 purified purify VBN cord-023865-6rafp3x3 47 6 recombinant recombinant JJ cord-023865-6rafp3x3 47 7 N n NN cord-023865-6rafp3x3 47 8 - - HYPH cord-023865-6rafp3x3 47 9 protein protein NN cord-023865-6rafp3x3 47 10 have have VBP cord-023865-6rafp3x3 47 11 shown show VBN cord-023865-6rafp3x3 47 12 it -PRON- PRP cord-023865-6rafp3x3 47 13 to to TO cord-023865-6rafp3x3 47 14 be be VB cord-023865-6rafp3x3 47 15 stable stable JJ cord-023865-6rafp3x3 47 16 between between IN cord-023865-6rafp3x3 47 17 pH pH NNP cord-023865-6rafp3x3 47 18 7 7 CD cord-023865-6rafp3x3 47 19 and and CC cord-023865-6rafp3x3 47 20 10 10 CD cord-023865-6rafp3x3 47 21 , , , cord-023865-6rafp3x3 47 22 with with IN cord-023865-6rafp3x3 47 23 maximum maximum JJ cord-023865-6rafp3x3 47 24 conformational conformational JJ cord-023865-6rafp3x3 47 25 stability stability NN cord-023865-6rafp3x3 47 26 near near IN cord-023865-6rafp3x3 47 27 pH pH NNP cord-023865-6rafp3x3 47 28 9 9 CD cord-023865-6rafp3x3 47 29 . . . cord-023865-6rafp3x3 48 1 Further further RB cord-023865-6rafp3x3 48 2 , , , cord-023865-6rafp3x3 48 3 it -PRON- PRP cord-023865-6rafp3x3 48 4 was be VBD cord-023865-6rafp3x3 48 5 observed observe VBN cord-023865-6rafp3x3 48 6 to to TO cord-023865-6rafp3x3 48 7 undergo undergo VB cord-023865-6rafp3x3 48 8 irreversible irreversible JJ cord-023865-6rafp3x3 48 9 thermal thermal JJ cord-023865-6rafp3x3 48 10 - - HYPH cord-023865-6rafp3x3 48 11 induced induce VBN cord-023865-6rafp3x3 48 12 denaturation denaturation NN cord-023865-6rafp3x3 48 13 . . . cord-023865-6rafp3x3 49 1 It -PRON- PRP cord-023865-6rafp3x3 49 2 starts start VBZ cord-023865-6rafp3x3 49 3 to to TO cord-023865-6rafp3x3 49 4 unfold unfold VB cord-023865-6rafp3x3 49 5 at at IN cord-023865-6rafp3x3 49 6 35 35 CD cord-023865-6rafp3x3 49 7 C c NN cord-023865-6rafp3x3 49 8 and and CC cord-023865-6rafp3x3 49 9 is be VBZ cord-023865-6rafp3x3 49 10 completely completely RB cord-023865-6rafp3x3 49 11 denatured denature VBN cord-023865-6rafp3x3 49 12 at at IN cord-023865-6rafp3x3 49 13 55 55 CD cord-023865-6rafp3x3 49 14 C c NN cord-023865-6rafp3x3 49 15 . . . cord-023865-6rafp3x3 50 1 However however RB cord-023865-6rafp3x3 50 2 , , , cord-023865-6rafp3x3 50 3 denaturation denaturation NN cord-023865-6rafp3x3 50 4 of of IN cord-023865-6rafp3x3 50 5 the the DT cord-023865-6rafp3x3 50 6 N N NNP cord-023865-6rafp3x3 50 7 - - HYPH cord-023865-6rafp3x3 50 8 protein protein NN cord-023865-6rafp3x3 50 9 induced induce VBN cord-023865-6rafp3x3 50 10 by by IN cord-023865-6rafp3x3 50 11 chemicals chemical NNS cord-023865-6rafp3x3 50 12 such such JJ cord-023865-6rafp3x3 50 13 as as IN cord-023865-6rafp3x3 50 14 urea urea NN cord-023865-6rafp3x3 50 15 or or CC cord-023865-6rafp3x3 50 16 guanidium guanidium NN cord-023865-6rafp3x3 50 17 chloride chloride NN cord-023865-6rafp3x3 50 18 is be VBZ cord-023865-6rafp3x3 50 19 a a DT cord-023865-6rafp3x3 50 20 reversible reversible JJ cord-023865-6rafp3x3 50 21 process process NN cord-023865-6rafp3x3 50 22 . . . cord-023865-6rafp3x3 51 1 As as IN cord-023865-6rafp3x3 51 2 in in IN cord-023865-6rafp3x3 51 3 other other JJ cord-023865-6rafp3x3 51 4 coronavirus coronavirus NN cord-023865-6rafp3x3 51 5 N n CD cord-023865-6rafp3x3 51 6 - - HYPH cord-023865-6rafp3x3 51 7 proteins protein NNS cord-023865-6rafp3x3 51 8 , , , cord-023865-6rafp3x3 51 9 SARS SARS NNP cord-023865-6rafp3x3 51 10 - - HYPH cord-023865-6rafp3x3 51 11 CoV CoV NNP cord-023865-6rafp3x3 51 12 N N NNP cord-023865-6rafp3x3 51 13 - - HYPH cord-023865-6rafp3x3 51 14 protein protein NN cord-023865-6rafp3x3 51 15 has have VBZ cord-023865-6rafp3x3 51 16 been be VBN cord-023865-6rafp3x3 51 17 predicted predict VBN cord-023865-6rafp3x3 51 18 and and CC cord-023865-6rafp3x3 51 19 later later RB cord-023865-6rafp3x3 51 20 experimentally experimentally RB cord-023865-6rafp3x3 51 21 proven prove VBN cord-023865-6rafp3x3 51 22 to to TO cord-023865-6rafp3x3 51 23 undergo undergo VB cord-023865-6rafp3x3 51 24 various various JJ cord-023865-6rafp3x3 51 25 posttranslational posttranslational JJ cord-023865-6rafp3x3 51 26 modifications modification NNS cord-023865-6rafp3x3 51 27 such such JJ cord-023865-6rafp3x3 51 28 as as IN cord-023865-6rafp3x3 51 29 acetylation acetylation NN cord-023865-6rafp3x3 51 30 , , , cord-023865-6rafp3x3 51 31 phosphorylation phosphorylation NN cord-023865-6rafp3x3 51 32 , , , cord-023865-6rafp3x3 51 33 and and CC cord-023865-6rafp3x3 51 34 sumoylation sumoylation NN cord-023865-6rafp3x3 51 35 . . . cord-023865-6rafp3x3 52 1 Acetylation Acetylation NNP cord-023865-6rafp3x3 52 2 is be VBZ cord-023865-6rafp3x3 52 3 the the DT cord-023865-6rafp3x3 52 4 first first JJ cord-023865-6rafp3x3 52 5 modification modification NN cord-023865-6rafp3x3 52 6 of of IN cord-023865-6rafp3x3 52 7 the the DT cord-023865-6rafp3x3 52 8 N n NN cord-023865-6rafp3x3 52 9 - - HYPH cord-023865-6rafp3x3 52 10 protein protein NN cord-023865-6rafp3x3 52 11 to to TO cord-023865-6rafp3x3 52 12 be be VB cord-023865-6rafp3x3 52 13 experimentally experimentally RB cord-023865-6rafp3x3 52 14 proven prove VBN cord-023865-6rafp3x3 52 15 . . . cord-023865-6rafp3x3 53 1 By by IN cord-023865-6rafp3x3 53 2 mass mass NNP cord-023865-6rafp3x3 53 3 spectrometric spectrometric NNP cord-023865-6rafp3x3 53 4 analysis analysis NN cord-023865-6rafp3x3 53 5 of of IN cord-023865-6rafp3x3 53 6 convalescent convalescent NNP cord-023865-6rafp3x3 53 7 sera sera NNP cord-023865-6rafp3x3 53 8 from from IN cord-023865-6rafp3x3 53 9 several several JJ cord-023865-6rafp3x3 53 10 SARS SARS NNP cord-023865-6rafp3x3 53 11 patients patient NNS cord-023865-6rafp3x3 53 12 , , , cord-023865-6rafp3x3 53 13 it -PRON- PRP cord-023865-6rafp3x3 53 14 has have VBZ cord-023865-6rafp3x3 53 15 been be VBN cord-023865-6rafp3x3 53 16 shown show VBN cord-023865-6rafp3x3 53 17 that that IN cord-023865-6rafp3x3 53 18 the the DT cord-023865-6rafp3x3 53 19 N n CD cord-023865-6rafp3x3 53 20 - - HYPH cord-023865-6rafp3x3 53 21 terminal terminal NN cord-023865-6rafp3x3 53 22 methionine methionine NN cord-023865-6rafp3x3 53 23 of of IN cord-023865-6rafp3x3 53 24 N N NNP cord-023865-6rafp3x3 53 25 is be VBZ cord-023865-6rafp3x3 53 26 removed remove VBN cord-023865-6rafp3x3 53 27 and and CC cord-023865-6rafp3x3 53 28 all all DT cord-023865-6rafp3x3 53 29 other other JJ cord-023865-6rafp3x3 53 30 methionines methionine NNS cord-023865-6rafp3x3 53 31 are be VBP cord-023865-6rafp3x3 53 32 oxidized oxidize VBN cord-023865-6rafp3x3 53 33 and and CC cord-023865-6rafp3x3 53 34 the the DT cord-023865-6rafp3x3 53 35 resulting result VBG cord-023865-6rafp3x3 53 36 N n CD cord-023865-6rafp3x3 53 37 - - HYPH cord-023865-6rafp3x3 53 38 terminal terminal JJ cord-023865-6rafp3x3 53 39 serine serine NN cord-023865-6rafp3x3 53 40 is be VBZ cord-023865-6rafp3x3 53 41 acetylated acetylated JJ cord-023865-6rafp3x3 53 42 . . . cord-023865-6rafp3x3 54 1 However however RB cord-023865-6rafp3x3 54 2 , , , cord-023865-6rafp3x3 54 3 the the DT cord-023865-6rafp3x3 54 4 functional functional JJ cord-023865-6rafp3x3 54 5 relevance relevance NN cord-023865-6rafp3x3 54 6 of of IN cord-023865-6rafp3x3 54 7 this this DT cord-023865-6rafp3x3 54 8 modification modification NN cord-023865-6rafp3x3 54 9 , , , cord-023865-6rafp3x3 54 10 if if IN cord-023865-6rafp3x3 54 11 any any DT cord-023865-6rafp3x3 54 12 , , , cord-023865-6rafp3x3 54 13 remains remain VBZ cord-023865-6rafp3x3 54 14 to to TO cord-023865-6rafp3x3 54 15 be be VB cord-023865-6rafp3x3 54 16 elucidated elucidate VBN cord-023865-6rafp3x3 55 1 ( ( -LRB- cord-023865-6rafp3x3 55 2 Krokhin Krokhin NNP cord-023865-6rafp3x3 55 3 et et NNP cord-023865-6rafp3x3 55 4 al al NNP cord-023865-6rafp3x3 55 5 . . NNP cord-023865-6rafp3x3 55 6 2003 2003 CD cord-023865-6rafp3x3 55 7 ) ) -RRB- cord-023865-6rafp3x3 55 8 . . . cord-023865-6rafp3x3 56 1 Another another DT cord-023865-6rafp3x3 56 2 unique unique JJ cord-023865-6rafp3x3 56 3 modification modification NN cord-023865-6rafp3x3 56 4 of of IN cord-023865-6rafp3x3 56 5 the the DT cord-023865-6rafp3x3 56 6 N n CD cord-023865-6rafp3x3 56 7 - - HYPH cord-023865-6rafp3x3 56 8 protein protein NN cord-023865-6rafp3x3 56 9 is be VBZ cord-023865-6rafp3x3 56 10 its -PRON- PRP$ cord-023865-6rafp3x3 56 11 ability ability NN cord-023865-6rafp3x3 56 12 to to TO cord-023865-6rafp3x3 56 13 become become VB cord-023865-6rafp3x3 56 14 sumoylated sumoylate VBN cord-023865-6rafp3x3 56 15 . . . cord-023865-6rafp3x3 57 1 Studies study NNS cord-023865-6rafp3x3 57 2 done do VBN cord-023865-6rafp3x3 57 3 by by IN cord-023865-6rafp3x3 57 4 Li Li NNP cord-023865-6rafp3x3 57 5 et et NNP cord-023865-6rafp3x3 57 6 al al NNP cord-023865-6rafp3x3 57 7 . . . cord-023865-6rafp3x3 58 1 ( ( -LRB- cord-023865-6rafp3x3 58 2 2005a 2005a LS cord-023865-6rafp3x3 58 3 ) ) -RRB- cord-023865-6rafp3x3 58 4 have have VBP cord-023865-6rafp3x3 58 5 clearly clearly RB cord-023865-6rafp3x3 58 6 established establish VBN cord-023865-6rafp3x3 58 7 that that IN cord-023865-6rafp3x3 58 8 heterologously heterologously NNP cord-023865-6rafp3x3 58 9 expressed express VBD cord-023865-6rafp3x3 58 10 N N NNP cord-023865-6rafp3x3 58 11 in in IN cord-023865-6rafp3x3 58 12 mammalian mammalian JJ cord-023865-6rafp3x3 58 13 cells cell NNS cord-023865-6rafp3x3 58 14 is be VBZ cord-023865-6rafp3x3 58 15 sumoylated sumoylate VBN cord-023865-6rafp3x3 58 16 . . . cord-023865-6rafp3x3 59 1 Using use VBG cord-023865-6rafp3x3 59 2 a a DT cord-023865-6rafp3x3 59 3 site site NN cord-023865-6rafp3x3 59 4 - - HYPH cord-023865-6rafp3x3 59 5 directed direct VBN cord-023865-6rafp3x3 59 6 mutagenesis mutagenesis NN cord-023865-6rafp3x3 59 7 approach approach NN cord-023865-6rafp3x3 59 8 , , , cord-023865-6rafp3x3 59 9 the the DT cord-023865-6rafp3x3 59 10 sumoylation sumoylation NN cord-023865-6rafp3x3 59 11 motif motif NN cord-023865-6rafp3x3 59 12 has have VBZ cord-023865-6rafp3x3 59 13 been be VBN cord-023865-6rafp3x3 59 14 mapped map VBN cord-023865-6rafp3x3 59 15 to to IN cord-023865-6rafp3x3 59 16 the the DT cord-023865-6rafp3x3 59 17 62nd 62nd JJ cord-023865-6rafp3x3 59 18 lysine lysine NN cord-023865-6rafp3x3 59 19 residue residue NN cord-023865-6rafp3x3 59 20 , , , cord-023865-6rafp3x3 59 21 which which WDT cord-023865-6rafp3x3 59 22 is be VBZ cord-023865-6rafp3x3 59 23 present present JJ cord-023865-6rafp3x3 59 24 in in IN cord-023865-6rafp3x3 59 25 a a DT cord-023865-6rafp3x3 59 26 putative putative JJ cord-023865-6rafp3x3 59 27 sumo sumo NN cord-023865-6rafp3x3 59 28 - - HYPH cord-023865-6rafp3x3 59 29 modification modification NN cord-023865-6rafp3x3 59 30 domain domain NN cord-023865-6rafp3x3 59 31 ( ( -LRB- cord-023865-6rafp3x3 59 32 GK GK NNP cord-023865-6rafp3x3 59 33 62 62 CD cord-023865-6rafp3x3 59 34 EE EE NNP cord-023865-6rafp3x3 59 35 ) ) -RRB- cord-023865-6rafp3x3 59 36 . . . cord-023865-6rafp3x3 60 1 Their -PRON- PRP$ cord-023865-6rafp3x3 60 2 data datum NNS cord-023865-6rafp3x3 60 3 further further RB cord-023865-6rafp3x3 60 4 suggests suggest VBZ cord-023865-6rafp3x3 60 5 that that IN cord-023865-6rafp3x3 60 6 sumoylation sumoylation NN cord-023865-6rafp3x3 60 7 may may MD cord-023865-6rafp3x3 60 8 play play VB cord-023865-6rafp3x3 60 9 a a DT cord-023865-6rafp3x3 60 10 key key JJ cord-023865-6rafp3x3 60 11 role role NN cord-023865-6rafp3x3 60 12 in in IN cord-023865-6rafp3x3 60 13 modulating modulate VBG cord-023865-6rafp3x3 60 14 homo homo NN cord-023865-6rafp3x3 60 15 - - HYPH cord-023865-6rafp3x3 60 16 oligomerization oligomerization NN cord-023865-6rafp3x3 60 17 , , , cord-023865-6rafp3x3 60 18 nucleolar nucleolar JJ cord-023865-6rafp3x3 60 19 translocation translocation NN cord-023865-6rafp3x3 60 20 and and CC cord-023865-6rafp3x3 60 21 cell cell NN cord-023865-6rafp3x3 60 22 - - HYPH cord-023865-6rafp3x3 60 23 cycle cycle NN cord-023865-6rafp3x3 60 24 deregulatory deregulatory JJ cord-023865-6rafp3x3 60 25 property property NN cord-023865-6rafp3x3 60 26 of of IN cord-023865-6rafp3x3 60 27 the the DT cord-023865-6rafp3x3 60 28 N N NNP cord-023865-6rafp3x3 60 29 - - HYPH cord-023865-6rafp3x3 60 30 protein protein NN cord-023865-6rafp3x3 60 31 . . . cord-023865-6rafp3x3 61 1 Further further JJ cord-023865-6rafp3x3 61 2 experimental experimental JJ cord-023865-6rafp3x3 61 3 support support NN cord-023865-6rafp3x3 61 4 regarding regard VBG cord-023865-6rafp3x3 61 5 sumoylation sumoylation NN cord-023865-6rafp3x3 61 6 of of IN cord-023865-6rafp3x3 61 7 N n CD cord-023865-6rafp3x3 61 8 - - HYPH cord-023865-6rafp3x3 61 9 protein protein NN cord-023865-6rafp3x3 61 10 came come VBD cord-023865-6rafp3x3 61 11 from from IN cord-023865-6rafp3x3 61 12 another another DT cord-023865-6rafp3x3 61 13 independent independent JJ cord-023865-6rafp3x3 61 14 study study NN cord-023865-6rafp3x3 61 15 carried carry VBN cord-023865-6rafp3x3 61 16 out out RP cord-023865-6rafp3x3 61 17 by by IN cord-023865-6rafp3x3 61 18 Fan Fan NNP cord-023865-6rafp3x3 61 19 et et NNP cord-023865-6rafp3x3 61 20 al al NNP cord-023865-6rafp3x3 61 21 . . . cord-023865-6rafp3x3 62 1 ( ( -LRB- cord-023865-6rafp3x3 62 2 2006 2006 CD cord-023865-6rafp3x3 62 3 ) ) -RRB- cord-023865-6rafp3x3 62 4 wherein wherein WRB cord-023865-6rafp3x3 62 5 they -PRON- PRP cord-023865-6rafp3x3 62 6 have have VBP cord-023865-6rafp3x3 62 7 demonstrated demonstrate VBN cord-023865-6rafp3x3 62 8 an an DT cord-023865-6rafp3x3 62 9 association association NN cord-023865-6rafp3x3 62 10 between between IN cord-023865-6rafp3x3 62 11 the the DT cord-023865-6rafp3x3 62 12 N N NNP cord-023865-6rafp3x3 62 13 - - HYPH cord-023865-6rafp3x3 62 14 protein protein NN cord-023865-6rafp3x3 62 15 and and CC cord-023865-6rafp3x3 62 16 Hubc9 Hubc9 NNP cord-023865-6rafp3x3 62 17 , , , cord-023865-6rafp3x3 62 18 which which WDT cord-023865-6rafp3x3 62 19 is be VBZ cord-023865-6rafp3x3 62 20 a a DT cord-023865-6rafp3x3 62 21 ubiquitinconjugating ubiquitinconjugate VBG cord-023865-6rafp3x3 62 22 enzyme enzyme NN cord-023865-6rafp3x3 62 23 of of IN cord-023865-6rafp3x3 62 24 the the DT cord-023865-6rafp3x3 62 25 sumoylation sumoylation NN cord-023865-6rafp3x3 62 26 system system NN cord-023865-6rafp3x3 62 27 . . . cord-023865-6rafp3x3 63 1 They -PRON- PRP cord-023865-6rafp3x3 63 2 have have VBP cord-023865-6rafp3x3 63 3 also also RB cord-023865-6rafp3x3 63 4 mapped map VBN cord-023865-6rafp3x3 63 5 the the DT cord-023865-6rafp3x3 63 6 interaction interaction NN cord-023865-6rafp3x3 63 7 domain domain NN cord-023865-6rafp3x3 63 8 to to IN cord-023865-6rafp3x3 63 9 the the DT cord-023865-6rafp3x3 63 10 SR SR NNP cord-023865-6rafp3x3 63 11 - - HYPH cord-023865-6rafp3x3 63 12 rich rich JJ cord-023865-6rafp3x3 63 13 motif motif NN cord-023865-6rafp3x3 63 14 , , , cord-023865-6rafp3x3 63 15 which which WDT cord-023865-6rafp3x3 63 16 is be VBZ cord-023865-6rafp3x3 63 17 in in IN cord-023865-6rafp3x3 63 18 agreement agreement NN cord-023865-6rafp3x3 63 19 with with IN cord-023865-6rafp3x3 63 20 the the DT cord-023865-6rafp3x3 63 21 earlier early JJR cord-023865-6rafp3x3 63 22 report report NN cord-023865-6rafp3x3 63 23 . . . cord-023865-6rafp3x3 64 1 However however RB cord-023865-6rafp3x3 64 2 , , , cord-023865-6rafp3x3 64 3 they -PRON- PRP cord-023865-6rafp3x3 64 4 failed fail VBD cord-023865-6rafp3x3 64 5 to to TO cord-023865-6rafp3x3 64 6 detect detect VB cord-023865-6rafp3x3 64 7 the the DT cord-023865-6rafp3x3 64 8 involvement involvement NN cord-023865-6rafp3x3 64 9 of of IN cord-023865-6rafp3x3 64 10 the the DT cord-023865-6rafp3x3 64 11 GKEE GKEE NNP cord-023865-6rafp3x3 64 12 motif motif NN cord-023865-6rafp3x3 64 13 in in IN cord-023865-6rafp3x3 64 14 mediating mediate VBG cord-023865-6rafp3x3 64 15 this this DT cord-023865-6rafp3x3 64 16 interaction interaction NN cord-023865-6rafp3x3 64 17 ( ( -LRB- cord-023865-6rafp3x3 64 18 Fan Fan NNP cord-023865-6rafp3x3 64 19 et et NNP cord-023865-6rafp3x3 64 20 al al NNP cord-023865-6rafp3x3 64 21 . . . cord-023865-6rafp3x3 64 22 2006 2006 CD cord-023865-6rafp3x3 64 23 ) ) -RRB- cord-023865-6rafp3x3 64 24 . . . cord-023865-6rafp3x3 65 1 Initially initially RB cord-023865-6rafp3x3 65 2 , , , cord-023865-6rafp3x3 65 3 the the DT cord-023865-6rafp3x3 65 4 SARS SARS NNP cord-023865-6rafp3x3 65 5 - - HYPH cord-023865-6rafp3x3 65 6 CoV CoV NNP cord-023865-6rafp3x3 65 7 N N NNP cord-023865-6rafp3x3 65 8 - - HYPH cord-023865-6rafp3x3 65 9 protein protein NN cord-023865-6rafp3x3 65 10 was be VBD cord-023865-6rafp3x3 65 11 predicted predict VBN cord-023865-6rafp3x3 65 12 to to TO cord-023865-6rafp3x3 65 13 be be VB cord-023865-6rafp3x3 65 14 heavily heavily RB cord-023865-6rafp3x3 65 15 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 65 16 . . . cord-023865-6rafp3x3 66 1 Later later RB cord-023865-6rafp3x3 66 2 on on RB cord-023865-6rafp3x3 66 3 , , , cord-023865-6rafp3x3 66 4 from from IN cord-023865-6rafp3x3 66 5 results result NNS cord-023865-6rafp3x3 66 6 obtained obtain VBN cord-023865-6rafp3x3 66 7 in in IN cord-023865-6rafp3x3 66 8 our -PRON- PRP$ cord-023865-6rafp3x3 66 9 laboratory laboratory NN cord-023865-6rafp3x3 66 10 as as RB cord-023865-6rafp3x3 66 11 well well RB cord-023865-6rafp3x3 66 12 as as IN cord-023865-6rafp3x3 66 13 by by IN cord-023865-6rafp3x3 66 14 other other JJ cord-023865-6rafp3x3 66 15 researchers researcher NNS cord-023865-6rafp3x3 66 16 , , , cord-023865-6rafp3x3 66 17 it -PRON- PRP cord-023865-6rafp3x3 66 18 is be VBZ cord-023865-6rafp3x3 66 19 now now RB cord-023865-6rafp3x3 66 20 clear clear JJ cord-023865-6rafp3x3 66 21 that that IN cord-023865-6rafp3x3 66 22 the the DT cord-023865-6rafp3x3 66 23 N N NNP cord-023865-6rafp3x3 66 24 - - HYPH cord-023865-6rafp3x3 66 25 protein protein NN cord-023865-6rafp3x3 66 26 is be VBZ cord-023865-6rafp3x3 66 27 a a DT cord-023865-6rafp3x3 66 28 substrate substrate NN cord-023865-6rafp3x3 66 29 of of IN cord-023865-6rafp3x3 66 30 multiple multiple JJ cord-023865-6rafp3x3 66 31 cellular cellular JJ cord-023865-6rafp3x3 66 32 kinases kinase NNS cord-023865-6rafp3x3 66 33 . . . cord-023865-6rafp3x3 67 1 First first JJ cord-023865-6rafp3x3 67 2 experimental experimental JJ cord-023865-6rafp3x3 67 3 evidence evidence NN cord-023865-6rafp3x3 67 4 for for IN cord-023865-6rafp3x3 67 5 the the DT cord-023865-6rafp3x3 67 6 phosphorylation phosphorylation NN cord-023865-6rafp3x3 67 7 status status NN cord-023865-6rafp3x3 67 8 of of IN cord-023865-6rafp3x3 67 9 the the DT cord-023865-6rafp3x3 67 10 N N NNP cord-023865-6rafp3x3 67 11 - - HYPH cord-023865-6rafp3x3 67 12 protein protein NN cord-023865-6rafp3x3 67 13 came come VBD cord-023865-6rafp3x3 67 14 from from IN cord-023865-6rafp3x3 67 15 the the DT cord-023865-6rafp3x3 67 16 study study NN cord-023865-6rafp3x3 67 17 done do VBN cord-023865-6rafp3x3 67 18 by by IN cord-023865-6rafp3x3 67 19 Zakhartchouk Zakhartchouk NNP cord-023865-6rafp3x3 67 20 et et NNP cord-023865-6rafp3x3 67 21 al al NNP cord-023865-6rafp3x3 67 22 . . . cord-023865-6rafp3x3 68 1 ( ( -LRB- cord-023865-6rafp3x3 68 2 2005 2005 CD cord-023865-6rafp3x3 68 3 ) ) -RRB- cord-023865-6rafp3x3 68 4 in in IN cord-023865-6rafp3x3 68 5 which which WDT cord-023865-6rafp3x3 68 6 , , , cord-023865-6rafp3x3 68 7 using use VBG cord-023865-6rafp3x3 68 8 [ [ -LRB- cord-023865-6rafp3x3 68 9 32 32 CD cord-023865-6rafp3x3 68 10 P]orthophosphate P]orthophosphate NNP cord-023865-6rafp3x3 68 11 labelling labelling NN cord-023865-6rafp3x3 68 12 , , , cord-023865-6rafp3x3 68 13 they -PRON- PRP cord-023865-6rafp3x3 68 14 were be VBD cord-023865-6rafp3x3 68 15 able able JJ cord-023865-6rafp3x3 68 16 to to TO cord-023865-6rafp3x3 68 17 observe observe VB cord-023865-6rafp3x3 68 18 phosphorylation phosphorylation NN cord-023865-6rafp3x3 68 19 of of IN cord-023865-6rafp3x3 68 20 adenovirus adenovirus NN cord-023865-6rafp3x3 68 21 - - HYPH cord-023865-6rafp3x3 68 22 vectorexpressed vectorexpresse VBN cord-023865-6rafp3x3 68 23 N n NN cord-023865-6rafp3x3 68 24 - - HYPH cord-023865-6rafp3x3 68 25 protein protein NN cord-023865-6rafp3x3 68 26 in in IN cord-023865-6rafp3x3 68 27 293 293 CD cord-023865-6rafp3x3 68 28 T T NNP cord-023865-6rafp3x3 68 29 cells cell NNS cord-023865-6rafp3x3 68 30 . . . cord-023865-6rafp3x3 69 1 Further further JJ cord-023865-6rafp3x3 69 2 studies study NNS cord-023865-6rafp3x3 69 3 done do VBN cord-023865-6rafp3x3 69 4 in in IN cord-023865-6rafp3x3 69 5 our -PRON- PRP$ cord-023865-6rafp3x3 69 6 laboratory laboratory NN cord-023865-6rafp3x3 69 7 clearly clearly RB cord-023865-6rafp3x3 69 8 confirmed confirm VBD cord-023865-6rafp3x3 69 9 this this DT cord-023865-6rafp3x3 69 10 observation observation NN cord-023865-6rafp3x3 69 11 . . . cord-023865-6rafp3x3 70 1 The the DT cord-023865-6rafp3x3 70 2 majority majority NN cord-023865-6rafp3x3 70 3 of of IN cord-023865-6rafp3x3 70 4 the the DT cord-023865-6rafp3x3 70 5 N N NNP cord-023865-6rafp3x3 70 6 - - HYPH cord-023865-6rafp3x3 70 7 protein protein NN cord-023865-6rafp3x3 70 8 was be VBD cord-023865-6rafp3x3 70 9 found find VBN cord-023865-6rafp3x3 70 10 to to TO cord-023865-6rafp3x3 70 11 be be VB cord-023865-6rafp3x3 70 12 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 70 13 at at IN cord-023865-6rafp3x3 70 14 its -PRON- PRP$ cord-023865-6rafp3x3 70 15 serine serine NN cord-023865-6rafp3x3 70 16 residues residue NNS cord-023865-6rafp3x3 70 17 ( ( -LRB- cord-023865-6rafp3x3 70 18 although although IN cord-023865-6rafp3x3 70 19 the the DT cord-023865-6rafp3x3 70 20 involvement involvement NN cord-023865-6rafp3x3 70 21 of of IN cord-023865-6rafp3x3 70 22 threonine threonine NN cord-023865-6rafp3x3 70 23 and and CC cord-023865-6rafp3x3 70 24 tyrosine tyrosine NN cord-023865-6rafp3x3 70 25 residues residue NNS cord-023865-6rafp3x3 70 26 could could MD cord-023865-6rafp3x3 70 27 not not RB cord-023865-6rafp3x3 70 28 be be VB cord-023865-6rafp3x3 70 29 detected detect VBN cord-023865-6rafp3x3 70 30 ; ; : cord-023865-6rafp3x3 70 31 they -PRON- PRP cord-023865-6rafp3x3 70 32 may may MD cord-023865-6rafp3x3 70 33 be be VB cord-023865-6rafp3x3 70 34 occurring occur VBG cord-023865-6rafp3x3 70 35 in in IN cord-023865-6rafp3x3 70 36 vivo vivo NN cord-023865-6rafp3x3 70 37 ) ) -RRB- cord-023865-6rafp3x3 70 38 . . . cord-023865-6rafp3x3 71 1 In in IN cord-023865-6rafp3x3 71 2 addition addition NN cord-023865-6rafp3x3 71 3 , , , cord-023865-6rafp3x3 71 4 using use VBG cord-023865-6rafp3x3 71 5 a a DT cord-023865-6rafp3x3 71 6 variety variety NN cord-023865-6rafp3x3 71 7 of of IN cord-023865-6rafp3x3 71 8 biochemical biochemical JJ cord-023865-6rafp3x3 71 9 assays assay NNS cord-023865-6rafp3x3 71 10 , , , cord-023865-6rafp3x3 71 11 it -PRON- PRP cord-023865-6rafp3x3 71 12 was be VBD cord-023865-6rafp3x3 71 13 proved prove VBN cord-023865-6rafp3x3 71 14 that that IN cord-023865-6rafp3x3 71 15 , , , cord-023865-6rafp3x3 71 16 at at IN cord-023865-6rafp3x3 71 17 least least JJS cord-023865-6rafp3x3 71 18 in in IN cord-023865-6rafp3x3 71 19 vitro vitro FW cord-023865-6rafp3x3 71 20 , , , cord-023865-6rafp3x3 71 21 the the DT cord-023865-6rafp3x3 71 22 N n NN cord-023865-6rafp3x3 71 23 - - HYPH cord-023865-6rafp3x3 71 24 protein protein NN cord-023865-6rafp3x3 71 25 could could MD cord-023865-6rafp3x3 71 26 become become VB cord-023865-6rafp3x3 71 27 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 71 28 by by IN cord-023865-6rafp3x3 71 29 mitogen mitogen NN cord-023865-6rafp3x3 71 30 - - HYPH cord-023865-6rafp3x3 71 31 activated activate VBN cord-023865-6rafp3x3 71 32 protein protein NN cord-023865-6rafp3x3 71 33 kinase kinase NN cord-023865-6rafp3x3 71 34 ( ( -LRB- cord-023865-6rafp3x3 71 35 MAP MAP NNP cord-023865-6rafp3x3 71 36 kinase kinase NN cord-023865-6rafp3x3 71 37 ) ) -RRB- cord-023865-6rafp3x3 71 38 , , , cord-023865-6rafp3x3 71 39 cyclin cyclin NN cord-023865-6rafp3x3 71 40 - - HYPH cord-023865-6rafp3x3 71 41 dependent dependent JJ cord-023865-6rafp3x3 71 42 kinase kinase NN cord-023865-6rafp3x3 71 43 ( ( -LRB- cord-023865-6rafp3x3 71 44 CDK CDK NNP cord-023865-6rafp3x3 71 45 ) ) -RRB- cord-023865-6rafp3x3 71 46 , , . cord-023865-6rafp3x3 72 1 glycogen glycogen NNP cord-023865-6rafp3x3 72 2 synthase synthase NN cord-023865-6rafp3x3 72 3 kinase kinase NNP cord-023865-6rafp3x3 72 4 3 3 CD cord-023865-6rafp3x3 72 5 ( ( -LRB- cord-023865-6rafp3x3 72 6 GSK3 GSK3 NNP cord-023865-6rafp3x3 72 7 ) ) -RRB- cord-023865-6rafp3x3 72 8 , , , cord-023865-6rafp3x3 72 9 and and CC cord-023865-6rafp3x3 72 10 casein casein NN cord-023865-6rafp3x3 72 11 kinase kinase NN cord-023865-6rafp3x3 72 12 2 2 CD cord-023865-6rafp3x3 73 1 ( ( -LRB- cord-023865-6rafp3x3 73 2 CK2 CK2 NNP cord-023865-6rafp3x3 73 3 ) ) -RRB- cord-023865-6rafp3x3 73 4 . . . cord-023865-6rafp3x3 74 1 Also also RB cord-023865-6rafp3x3 74 2 , , , cord-023865-6rafp3x3 74 3 this this DT cord-023865-6rafp3x3 74 4 data datum NNS cord-023865-6rafp3x3 74 5 provided provide VBD cord-023865-6rafp3x3 74 6 preliminary preliminary JJ cord-023865-6rafp3x3 74 7 indication indication NN cord-023865-6rafp3x3 74 8 regarding regard VBG cord-023865-6rafp3x3 74 9 phosphorylation phosphorylation NN cord-023865-6rafp3x3 74 10 - - HYPH cord-023865-6rafp3x3 74 11 dependent dependent JJ cord-023865-6rafp3x3 74 12 nucleo nucleo JJ cord-023865-6rafp3x3 74 13 - - JJ cord-023865-6rafp3x3 74 14 cytoplasmic cytoplasmic JJ cord-023865-6rafp3x3 74 15 shuttling shuttling NN cord-023865-6rafp3x3 74 16 of of IN cord-023865-6rafp3x3 74 17 the the DT cord-023865-6rafp3x3 74 18 N n NN cord-023865-6rafp3x3 74 19 - - HYPH cord-023865-6rafp3x3 74 20 protein protein NN cord-023865-6rafp3x3 74 21 ( ( -LRB- cord-023865-6rafp3x3 74 22 Surjit Surjit NNP cord-023865-6rafp3x3 74 23 et et NNP cord-023865-6rafp3x3 74 24 al al NNP cord-023865-6rafp3x3 74 25 . . NNP cord-023865-6rafp3x3 74 26 2005 2005 CD cord-023865-6rafp3x3 74 27 ) ) -RRB- cord-023865-6rafp3x3 74 28 . . . cord-023865-6rafp3x3 75 1 A a DT cord-023865-6rafp3x3 75 2 recent recent JJ cord-023865-6rafp3x3 75 3 report report NN cord-023865-6rafp3x3 75 4 published publish VBN cord-023865-6rafp3x3 75 5 by by IN cord-023865-6rafp3x3 75 6 Wu Wu NNP cord-023865-6rafp3x3 75 7 et et NNP cord-023865-6rafp3x3 75 8 al al NNP cord-023865-6rafp3x3 75 9 . . . cord-023865-6rafp3x3 76 1 ( ( -LRB- cord-023865-6rafp3x3 76 2 2008 2008 CD cord-023865-6rafp3x3 76 3 ) ) -RRB- cord-023865-6rafp3x3 76 4 has have VBZ cord-023865-6rafp3x3 76 5 further further RB cord-023865-6rafp3x3 76 6 confirmed confirm VBN cord-023865-6rafp3x3 76 7 that that IN cord-023865-6rafp3x3 76 8 N n NN cord-023865-6rafp3x3 76 9 - - HYPH cord-023865-6rafp3x3 76 10 protein protein NN cord-023865-6rafp3x3 76 11 is be VBZ cord-023865-6rafp3x3 76 12 a a DT cord-023865-6rafp3x3 76 13 substrate substrate NN cord-023865-6rafp3x3 76 14 of of IN cord-023865-6rafp3x3 76 15 GSK3 GSK3 NNP cord-023865-6rafp3x3 76 16 enzyme enzyme NN cord-023865-6rafp3x3 76 17 , , , cord-023865-6rafp3x3 76 18 both both DT cord-023865-6rafp3x3 76 19 in in IN cord-023865-6rafp3x3 76 20 vitro vitro FW cord-023865-6rafp3x3 76 21 and and CC cord-023865-6rafp3x3 76 22 in in IN cord-023865-6rafp3x3 76 23 vivo vivo NNP cord-023865-6rafp3x3 76 24 . . . cord-023865-6rafp3x3 77 1 Using use VBG cord-023865-6rafp3x3 77 2 a a DT cord-023865-6rafp3x3 77 3 variety variety NN cord-023865-6rafp3x3 77 4 of of IN cord-023865-6rafp3x3 77 5 biochemical biochemical JJ cord-023865-6rafp3x3 77 6 and and CC cord-023865-6rafp3x3 77 7 genetic genetic JJ cord-023865-6rafp3x3 77 8 assays assay NNS cord-023865-6rafp3x3 77 9 , , , cord-023865-6rafp3x3 77 10 it -PRON- PRP cord-023865-6rafp3x3 77 11 was be VBD cord-023865-6rafp3x3 77 12 clearly clearly RB cord-023865-6rafp3x3 77 13 demonstrated demonstrate VBN cord-023865-6rafp3x3 77 14 that that IN cord-023865-6rafp3x3 77 15 serine serine NN cord-023865-6rafp3x3 77 16 177 177 CD cord-023865-6rafp3x3 77 17 residue residue NN cord-023865-6rafp3x3 77 18 of of IN cord-023865-6rafp3x3 77 19 N n NN cord-023865-6rafp3x3 77 20 - - HYPH cord-023865-6rafp3x3 77 21 protein protein NN cord-023865-6rafp3x3 77 22 was be VBD cord-023865-6rafp3x3 77 23 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 77 24 by by IN cord-023865-6rafp3x3 77 25 GSK3 GSK3 NNP cord-023865-6rafp3x3 77 26 . . . cord-023865-6rafp3x3 78 1 An an DT cord-023865-6rafp3x3 78 2 antibody antibody NN cord-023865-6rafp3x3 78 3 specific specific JJ cord-023865-6rafp3x3 78 4 to to IN cord-023865-6rafp3x3 78 5 phospho phospho NN cord-023865-6rafp3x3 78 6 177 177 CD cord-023865-6rafp3x3 78 7 residue residue NN cord-023865-6rafp3x3 78 8 of of IN cord-023865-6rafp3x3 78 9 the the DT cord-023865-6rafp3x3 78 10 N n NN cord-023865-6rafp3x3 78 11 - - HYPH cord-023865-6rafp3x3 78 12 protein protein NN cord-023865-6rafp3x3 78 13 could could MD cord-023865-6rafp3x3 78 14 efficiently efficiently RB cord-023865-6rafp3x3 78 15 detect detect VB cord-023865-6rafp3x3 78 16 the the DT cord-023865-6rafp3x3 78 17 phospho phospho NNP cord-023865-6rafp3x3 78 18 N N NNP cord-023865-6rafp3x3 78 19 - - HYPH cord-023865-6rafp3x3 78 20 protein protein NN cord-023865-6rafp3x3 78 21 both both DT cord-023865-6rafp3x3 78 22 in in IN cord-023865-6rafp3x3 78 23 vitro vitro FW cord-023865-6rafp3x3 78 24 and and CC cord-023865-6rafp3x3 78 25 in in IN cord-023865-6rafp3x3 78 26 SARS SARS NNP cord-023865-6rafp3x3 78 27 - - HYPH cord-023865-6rafp3x3 78 28 CoV CoV NNP cord-023865-6rafp3x3 78 29 infected infected JJ cord-023865-6rafp3x3 78 30 cells cell NNS cord-023865-6rafp3x3 78 31 . . . cord-023865-6rafp3x3 79 1 Interestingly interestingly RB cord-023865-6rafp3x3 79 2 , , , cord-023865-6rafp3x3 79 3 biochemically biochemically RB cord-023865-6rafp3x3 79 4 mediated mediate VBN cord-023865-6rafp3x3 79 5 inhibition inhibition NN cord-023865-6rafp3x3 79 6 of of IN cord-023865-6rafp3x3 79 7 GSK3 GSK3 NNP cord-023865-6rafp3x3 79 8 activity activity NN cord-023865-6rafp3x3 79 9 in in IN cord-023865-6rafp3x3 79 10 SARS SARS NNP cord-023865-6rafp3x3 79 11 - - HYPH cord-023865-6rafp3x3 79 12 CoV CoV NNP cord-023865-6rafp3x3 79 13 infected infect VBN cord-023865-6rafp3x3 79 14 cells cell NNS cord-023865-6rafp3x3 79 15 also also RB cord-023865-6rafp3x3 79 16 leads lead VBZ cord-023865-6rafp3x3 79 17 to to IN cord-023865-6rafp3x3 79 18 around around IN cord-023865-6rafp3x3 79 19 80 80 CD cord-023865-6rafp3x3 79 20 % % NN cord-023865-6rafp3x3 79 21 reduction reduction NN cord-023865-6rafp3x3 79 22 in in IN cord-023865-6rafp3x3 79 23 viral viral JJ cord-023865-6rafp3x3 79 24 titer titer NN cord-023865-6rafp3x3 79 25 and and CC cord-023865-6rafp3x3 79 26 subsequent subsequent JJ cord-023865-6rafp3x3 79 27 induction induction NN cord-023865-6rafp3x3 79 28 of of IN cord-023865-6rafp3x3 79 29 a a DT cord-023865-6rafp3x3 79 30 virus virus NN cord-023865-6rafp3x3 79 31 - - HYPH cord-023865-6rafp3x3 79 32 induced induce VBN cord-023865-6rafp3x3 79 33 cytopathic cytopathic JJ cord-023865-6rafp3x3 79 34 effect effect NN cord-023865-6rafp3x3 79 35 . . . cord-023865-6rafp3x3 80 1 The the DT cord-023865-6rafp3x3 80 2 authors author NNS cord-023865-6rafp3x3 80 3 proposed propose VBD cord-023865-6rafp3x3 80 4 that that IN cord-023865-6rafp3x3 80 5 GSK3 GSK3 NNP cord-023865-6rafp3x3 80 6 may may MD cord-023865-6rafp3x3 80 7 be be VB cord-023865-6rafp3x3 80 8 a a DT cord-023865-6rafp3x3 80 9 major major JJ cord-023865-6rafp3x3 80 10 regulator regulator NN cord-023865-6rafp3x3 80 11 of of IN cord-023865-6rafp3x3 80 12 SARS SARS NNP cord-023865-6rafp3x3 80 13 - - HYPH cord-023865-6rafp3x3 80 14 CoV CoV NNP cord-023865-6rafp3x3 80 15 replication replication NN cord-023865-6rafp3x3 80 16 , , , cord-023865-6rafp3x3 80 17 possibly possibly RB cord-023865-6rafp3x3 80 18 by by IN cord-023865-6rafp3x3 80 19 virtue virtue NN cord-023865-6rafp3x3 80 20 of of IN cord-023865-6rafp3x3 80 21 its -PRON- PRP$ cord-023865-6rafp3x3 80 22 ability ability NN cord-023865-6rafp3x3 80 23 to to TO cord-023865-6rafp3x3 80 24 phosphorylate phosphorylate VB cord-023865-6rafp3x3 80 25 the the DT cord-023865-6rafp3x3 80 26 N n NN cord-023865-6rafp3x3 80 27 - - HYPH cord-023865-6rafp3x3 80 28 protein protein NN cord-023865-6rafp3x3 80 29 . . . cord-023865-6rafp3x3 81 1 However however RB cord-023865-6rafp3x3 81 2 , , , cord-023865-6rafp3x3 81 3 phosphorylation phosphorylation NN cord-023865-6rafp3x3 81 4 of of IN cord-023865-6rafp3x3 81 5 other other JJ cord-023865-6rafp3x3 81 6 viral viral NN cord-023865-6rafp3x3 81 7 and/or and/or CC cord-023865-6rafp3x3 81 8 host host NN cord-023865-6rafp3x3 81 9 proteins protein NNS cord-023865-6rafp3x3 81 10 by by IN cord-023865-6rafp3x3 81 11 GSK3 GSK3 NNP cord-023865-6rafp3x3 81 12 may may MD cord-023865-6rafp3x3 81 13 also also RB cord-023865-6rafp3x3 81 14 be be VB cord-023865-6rafp3x3 81 15 a a DT cord-023865-6rafp3x3 81 16 determinant determinant NN cord-023865-6rafp3x3 81 17 of of IN cord-023865-6rafp3x3 81 18 the the DT cord-023865-6rafp3x3 81 19 observed observed JJ cord-023865-6rafp3x3 81 20 cytopathic cytopathic JJ cord-023865-6rafp3x3 81 21 effect effect NN cord-023865-6rafp3x3 81 22 . . . cord-023865-6rafp3x3 82 1 In in IN cord-023865-6rafp3x3 82 2 contrast contrast NN cord-023865-6rafp3x3 82 3 to to IN cord-023865-6rafp3x3 82 4 the the DT cord-023865-6rafp3x3 82 5 N n NN cord-023865-6rafp3x3 82 6 - - HYPH cord-023865-6rafp3x3 82 7 protein protein NN cord-023865-6rafp3x3 82 8 of of IN cord-023865-6rafp3x3 82 9 many many JJ cord-023865-6rafp3x3 82 10 other other JJ cord-023865-6rafp3x3 82 11 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 82 12 , , , cord-023865-6rafp3x3 82 13 the the DT cord-023865-6rafp3x3 82 14 SARS SARS NNP cord-023865-6rafp3x3 82 15 - - HYPH cord-023865-6rafp3x3 82 16 CoV CoV NNP cord-023865-6rafp3x3 82 17 N N NNP cord-023865-6rafp3x3 82 18 - - HYPH cord-023865-6rafp3x3 82 19 protein protein NN cord-023865-6rafp3x3 82 20 is be VBZ cord-023865-6rafp3x3 82 21 predominantly predominantly RB cord-023865-6rafp3x3 82 22 distributed distribute VBN cord-023865-6rafp3x3 82 23 in in IN cord-023865-6rafp3x3 82 24 the the DT cord-023865-6rafp3x3 82 25 cytoplasm cytoplasm NN cord-023865-6rafp3x3 82 26 , , , cord-023865-6rafp3x3 82 27 when when WRB cord-023865-6rafp3x3 82 28 expressed express VBN cord-023865-6rafp3x3 82 29 heterologously heterologously NNP cord-023865-6rafp3x3 82 30 or or CC cord-023865-6rafp3x3 82 31 in in IN cord-023865-6rafp3x3 82 32 infected infected JJ cord-023865-6rafp3x3 82 33 cells cell NNS cord-023865-6rafp3x3 82 34 ( ( -LRB- cord-023865-6rafp3x3 82 35 Surjit Surjit NNP cord-023865-6rafp3x3 82 36 et et NNP cord-023865-6rafp3x3 82 37 al al NNP cord-023865-6rafp3x3 82 38 . . NNP cord-023865-6rafp3x3 82 39 2005 2005 CD cord-023865-6rafp3x3 82 40 ; ; . cord-023865-6rafp3x3 83 1 You -PRON- PRP cord-023865-6rafp3x3 83 2 et et FW cord-023865-6rafp3x3 83 3 al al NNP cord-023865-6rafp3x3 83 4 . . . cord-023865-6rafp3x3 84 1 2005 2005 CD cord-023865-6rafp3x3 84 2 ; ; : cord-023865-6rafp3x3 84 3 Rowland Rowland NNP cord-023865-6rafp3x3 84 4 et et NNP cord-023865-6rafp3x3 84 5 al al NNP cord-023865-6rafp3x3 84 6 . . NNP cord-023865-6rafp3x3 84 7 2005 2005 CD cord-023865-6rafp3x3 84 8 ) ) -RRB- cord-023865-6rafp3x3 84 9 . . . cord-023865-6rafp3x3 85 1 In in IN cord-023865-6rafp3x3 85 2 infected infected JJ cord-023865-6rafp3x3 85 3 cells cell NNS cord-023865-6rafp3x3 85 4 , , , cord-023865-6rafp3x3 85 5 a a DT cord-023865-6rafp3x3 85 6 few few JJ cord-023865-6rafp3x3 85 7 cells cell NNS cord-023865-6rafp3x3 85 8 exhibited exhibit VBD cord-023865-6rafp3x3 85 9 nucleolar nucleolar JJ cord-023865-6rafp3x3 85 10 localization localization NN cord-023865-6rafp3x3 85 11 ( ( -LRB- cord-023865-6rafp3x3 85 12 You -PRON- PRP cord-023865-6rafp3x3 85 13 et et FW cord-023865-6rafp3x3 85 14 al al NNP cord-023865-6rafp3x3 85 15 . . NNP cord-023865-6rafp3x3 85 16 2005 2005 CD cord-023865-6rafp3x3 85 17 ) ) -RRB- cord-023865-6rafp3x3 85 18 . . . cord-023865-6rafp3x3 86 1 As as IN cord-023865-6rafp3x3 86 2 reported report VBN cord-023865-6rafp3x3 86 3 by by IN cord-023865-6rafp3x3 86 4 You -PRON- PRP cord-023865-6rafp3x3 86 5 et et FW cord-023865-6rafp3x3 86 6 al al NNP cord-023865-6rafp3x3 86 7 . . . cord-023865-6rafp3x3 87 1 ( ( -LRB- cord-023865-6rafp3x3 87 2 2005 2005 CD cord-023865-6rafp3x3 87 3 ) ) -RRB- cord-023865-6rafp3x3 87 4 , , , cord-023865-6rafp3x3 87 5 the the DT cord-023865-6rafp3x3 87 6 N N NNP cord-023865-6rafp3x3 87 7 - - HYPH cord-023865-6rafp3x3 87 8 protein protein NN cord-023865-6rafp3x3 87 9 contains contain VBZ cord-023865-6rafp3x3 87 10 pat4 pat4 NN cord-023865-6rafp3x3 87 11 , , , cord-023865-6rafp3x3 87 12 pat7 pat7 NN cord-023865-6rafp3x3 87 13 and and CC cord-023865-6rafp3x3 87 14 bipartite bipartite JJ cord-023865-6rafp3x3 87 15 - - HYPH cord-023865-6rafp3x3 87 16 type type NN cord-023865-6rafp3x3 87 17 nuclear nuclear JJ cord-023865-6rafp3x3 87 18 localization localization NN cord-023865-6rafp3x3 87 19 signals signal NNS cord-023865-6rafp3x3 87 20 . . . cord-023865-6rafp3x3 88 1 It -PRON- PRP cord-023865-6rafp3x3 88 2 has have VBZ cord-023865-6rafp3x3 88 3 also also RB cord-023865-6rafp3x3 88 4 been be VBN cord-023865-6rafp3x3 88 5 predicted predict VBN cord-023865-6rafp3x3 88 6 to to TO cord-023865-6rafp3x3 88 7 possess possess VB cord-023865-6rafp3x3 88 8 a a DT cord-023865-6rafp3x3 88 9 potential potential JJ cord-023865-6rafp3x3 88 10 CRM-1dependent crm-1dependent NN cord-023865-6rafp3x3 88 11 nuclear nuclear JJ cord-023865-6rafp3x3 88 12 export export NN cord-023865-6rafp3x3 88 13 signal signal NN cord-023865-6rafp3x3 88 14 . . . cord-023865-6rafp3x3 89 1 However however RB cord-023865-6rafp3x3 89 2 , , , cord-023865-6rafp3x3 89 3 no no DT cord-023865-6rafp3x3 89 4 clear clear JJ cord-023865-6rafp3x3 89 5 experimental experimental JJ cord-023865-6rafp3x3 89 6 evidence evidence NN cord-023865-6rafp3x3 89 7 could could MD cord-023865-6rafp3x3 89 8 be be VB cord-023865-6rafp3x3 89 9 obtained obtain VBN cord-023865-6rafp3x3 89 10 regarding regard VBG cord-023865-6rafp3x3 89 11 the the DT cord-023865-6rafp3x3 89 12 involvement involvement NN cord-023865-6rafp3x3 89 13 of of IN cord-023865-6rafp3x3 89 14 these these DT cord-023865-6rafp3x3 89 15 signature signature NN cord-023865-6rafp3x3 89 16 sequences sequence NNS cord-023865-6rafp3x3 89 17 in in IN cord-023865-6rafp3x3 89 18 regulating regulate VBG cord-023865-6rafp3x3 89 19 the the DT cord-023865-6rafp3x3 89 20 localization localization NN cord-023865-6rafp3x3 89 21 of of IN cord-023865-6rafp3x3 89 22 the the DT cord-023865-6rafp3x3 89 23 N N NNP cord-023865-6rafp3x3 89 24 - - HYPH cord-023865-6rafp3x3 89 25 protein protein NN cord-023865-6rafp3x3 89 26 . . . cord-023865-6rafp3x3 90 1 Interestingly interestingly RB cord-023865-6rafp3x3 90 2 , , , cord-023865-6rafp3x3 90 3 studies study NNS cord-023865-6rafp3x3 90 4 done do VBN cord-023865-6rafp3x3 90 5 in in IN cord-023865-6rafp3x3 90 6 our -PRON- PRP$ cord-023865-6rafp3x3 90 7 laboratory laboratory NN cord-023865-6rafp3x3 90 8 revealed reveal VBD cord-023865-6rafp3x3 90 9 that that IN cord-023865-6rafp3x3 90 10 the the DT cord-023865-6rafp3x3 90 11 majority majority NN cord-023865-6rafp3x3 90 12 of of IN cord-023865-6rafp3x3 90 13 N n NN cord-023865-6rafp3x3 90 14 - - HYPH cord-023865-6rafp3x3 90 15 protein protein NN cord-023865-6rafp3x3 90 16 localized localize VBN cord-023865-6rafp3x3 90 17 to to IN cord-023865-6rafp3x3 90 18 the the DT cord-023865-6rafp3x3 90 19 nucleus nucleus NN cord-023865-6rafp3x3 90 20 in in IN cord-023865-6rafp3x3 90 21 serum serum NN cord-023865-6rafp3x3 90 22 - - HYPH cord-023865-6rafp3x3 90 23 starved starve VBN cord-023865-6rafp3x3 90 24 cells cell NNS cord-023865-6rafp3x3 90 25 . . . cord-023865-6rafp3x3 91 1 This this DT cord-023865-6rafp3x3 91 2 phenomenon phenomenon NN cord-023865-6rafp3x3 91 3 could could MD cord-023865-6rafp3x3 91 4 be be VB cord-023865-6rafp3x3 91 5 reproducibly reproducibly RB cord-023865-6rafp3x3 91 6 observed observe VBN cord-023865-6rafp3x3 91 7 both both CC cord-023865-6rafp3x3 91 8 in in IN cord-023865-6rafp3x3 91 9 biochemical biochemical JJ cord-023865-6rafp3x3 91 10 fractionation fractionation NN cord-023865-6rafp3x3 91 11 as as RB cord-023865-6rafp3x3 91 12 well well RB cord-023865-6rafp3x3 91 13 as as IN cord-023865-6rafp3x3 91 14 immunofluorescence immunofluorescence NN cord-023865-6rafp3x3 91 15 studies study NNS cord-023865-6rafp3x3 91 16 . . . cord-023865-6rafp3x3 92 1 In in IN cord-023865-6rafp3x3 92 2 addition addition NN cord-023865-6rafp3x3 92 3 , , , cord-023865-6rafp3x3 92 4 treatment treatment NN cord-023865-6rafp3x3 92 5 of of IN cord-023865-6rafp3x3 92 6 cells cell NNS cord-023865-6rafp3x3 92 7 with with IN cord-023865-6rafp3x3 92 8 specific specific JJ cord-023865-6rafp3x3 92 9 inhibitors inhibitor NNS cord-023865-6rafp3x3 92 10 of of IN cord-023865-6rafp3x3 92 11 different different JJ cord-023865-6rafp3x3 92 12 cellular cellular JJ cord-023865-6rafp3x3 92 13 kinases kinase NNS cord-023865-6rafp3x3 92 14 such such JJ cord-023865-6rafp3x3 92 15 as as IN cord-023865-6rafp3x3 92 16 CK2 CK2 NNP cord-023865-6rafp3x3 92 17 inhibitor inhibitor NN cord-023865-6rafp3x3 92 18 and and CC cord-023865-6rafp3x3 92 19 CDK CDK NNP cord-023865-6rafp3x3 92 20 inhibitor inhibitor NN cord-023865-6rafp3x3 92 21 resulted result VBD cord-023865-6rafp3x3 92 22 in in IN cord-023865-6rafp3x3 92 23 retention retention NN cord-023865-6rafp3x3 92 24 of of IN cord-023865-6rafp3x3 92 25 a a DT cord-023865-6rafp3x3 92 26 fraction fraction NN cord-023865-6rafp3x3 92 27 of of IN cord-023865-6rafp3x3 92 28 the the DT cord-023865-6rafp3x3 92 29 N n NN cord-023865-6rafp3x3 92 30 - - HYPH cord-023865-6rafp3x3 92 31 protein protein NN cord-023865-6rafp3x3 92 32 in in IN cord-023865-6rafp3x3 92 33 the the DT cord-023865-6rafp3x3 92 34 nucleus nucleus NN cord-023865-6rafp3x3 92 35 , , , cord-023865-6rafp3x3 92 36 whereas whereas IN cord-023865-6rafp3x3 92 37 GSK3 GSK3 NNP cord-023865-6rafp3x3 92 38 and and CC cord-023865-6rafp3x3 92 39 MAPK MAPK NNP cord-023865-6rafp3x3 92 40 inhibitor inhibitor NN cord-023865-6rafp3x3 92 41 had have VBD cord-023865-6rafp3x3 92 42 very very RB cord-023865-6rafp3x3 92 43 little little JJ cord-023865-6rafp3x3 92 44 effect effect NN cord-023865-6rafp3x3 92 45 . . . cord-023865-6rafp3x3 93 1 Further further RB cord-023865-6rafp3x3 93 2 , , , cord-023865-6rafp3x3 93 3 N n CD cord-023865-6rafp3x3 93 4 - - HYPH cord-023865-6rafp3x3 93 5 protein protein NN cord-023865-6rafp3x3 93 6 was be VBD cord-023865-6rafp3x3 93 7 found find VBN cord-023865-6rafp3x3 93 8 to to TO cord-023865-6rafp3x3 93 9 be be VB cord-023865-6rafp3x3 93 10 efficiently efficiently RB cord-023865-6rafp3x3 93 11 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 93 12 by by IN cord-023865-6rafp3x3 93 13 the the DT cord-023865-6rafp3x3 93 14 cyclin cyclin NN cord-023865-6rafp3x3 93 15 - - HYPH cord-023865-6rafp3x3 93 16 CDK CDK NNP cord-023865-6rafp3x3 93 17 complex complex NN cord-023865-6rafp3x3 93 18 , , , cord-023865-6rafp3x3 93 19 which which WDT cord-023865-6rafp3x3 93 20 is be VBZ cord-023865-6rafp3x3 93 21 known know VBN cord-023865-6rafp3x3 93 22 to to TO cord-023865-6rafp3x3 93 23 be be VB cord-023865-6rafp3x3 93 24 active active JJ cord-023865-6rafp3x3 93 25 only only RB cord-023865-6rafp3x3 93 26 in in IN cord-023865-6rafp3x3 93 27 the the DT cord-023865-6rafp3x3 93 28 nucleus nucleus NN cord-023865-6rafp3x3 93 29 . . . cord-023865-6rafp3x3 94 1 The the DT cord-023865-6rafp3x3 94 2 N N NNP cord-023865-6rafp3x3 94 3 - - HYPH cord-023865-6rafp3x3 94 4 protein protein NN cord-023865-6rafp3x3 94 5 was be VBD cord-023865-6rafp3x3 94 6 also also RB cord-023865-6rafp3x3 94 7 found find VBN cord-023865-6rafp3x3 94 8 to to TO cord-023865-6rafp3x3 94 9 associate associate VB cord-023865-6rafp3x3 94 10 with with IN cord-023865-6rafp3x3 94 11 14 14 CD cord-023865-6rafp3x3 94 12 - - SYM cord-023865-6rafp3x3 94 13 3 3 CD cord-023865-6rafp3x3 94 14 - - SYM cord-023865-6rafp3x3 94 15 3 3 CD cord-023865-6rafp3x3 94 16 protein protein NN cord-023865-6rafp3x3 94 17 in in IN cord-023865-6rafp3x3 94 18 a a DT cord-023865-6rafp3x3 94 19 phospho phospho NN cord-023865-6rafp3x3 94 20 - - HYPH cord-023865-6rafp3x3 94 21 specific specific JJ cord-023865-6rafp3x3 94 22 manner manner NN cord-023865-6rafp3x3 94 23 and and CC cord-023865-6rafp3x3 94 24 inhibition inhibition NN cord-023865-6rafp3x3 94 25 of of IN cord-023865-6rafp3x3 94 26 the the DT cord-023865-6rafp3x3 94 27 14 14 CD cord-023865-6rafp3x3 94 28 - - SYM cord-023865-6rafp3x3 94 29 3 3 CD cord-023865-6rafp3x3 94 30 - - HYPH cord-023865-6rafp3x3 94 31 3y 3y JJ cord-023865-6rafp3x3 94 32 protein protein NN cord-023865-6rafp3x3 94 33 level level NN cord-023865-6rafp3x3 94 34 by by IN cord-023865-6rafp3x3 94 35 siRNA siRNA NNP cord-023865-6rafp3x3 94 36 resulted result VBD cord-023865-6rafp3x3 94 37 in in IN cord-023865-6rafp3x3 94 38 nuclear nuclear JJ cord-023865-6rafp3x3 94 39 accumulation accumulation NN cord-023865-6rafp3x3 94 40 of of IN cord-023865-6rafp3x3 94 41 the the DT cord-023865-6rafp3x3 94 42 N n NN cord-023865-6rafp3x3 94 43 - - HYPH cord-023865-6rafp3x3 94 44 protein protein NN cord-023865-6rafp3x3 94 45 . . . cord-023865-6rafp3x3 95 1 Although although IN cord-023865-6rafp3x3 95 2 these these DT cord-023865-6rafp3x3 95 3 experiments experiment NNS cord-023865-6rafp3x3 95 4 are be VBP cord-023865-6rafp3x3 95 5 too too RB cord-023865-6rafp3x3 95 6 preliminary preliminary JJ cord-023865-6rafp3x3 95 7 to to TO cord-023865-6rafp3x3 95 8 conclusively conclusively RB cord-023865-6rafp3x3 95 9 provide provide VB cord-023865-6rafp3x3 95 10 any any DT cord-023865-6rafp3x3 95 11 answer answer NN cord-023865-6rafp3x3 95 12 regarding regard VBG cord-023865-6rafp3x3 95 13 the the DT cord-023865-6rafp3x3 95 14 intracellular intracellular JJ cord-023865-6rafp3x3 95 15 localization localization NN cord-023865-6rafp3x3 95 16 of of IN cord-023865-6rafp3x3 95 17 N n NN cord-023865-6rafp3x3 95 18 - - HYPH cord-023865-6rafp3x3 95 19 protein protein NN cord-023865-6rafp3x3 95 20 , , , cord-023865-6rafp3x3 95 21 nevertheless nevertheless RB cord-023865-6rafp3x3 95 22 they -PRON- PRP cord-023865-6rafp3x3 95 23 do do VBP cord-023865-6rafp3x3 95 24 provide provide VB cord-023865-6rafp3x3 95 25 substantial substantial JJ cord-023865-6rafp3x3 95 26 clues clue NNS cord-023865-6rafp3x3 95 27 regarding regard VBG cord-023865-6rafp3x3 95 28 the the DT cord-023865-6rafp3x3 95 29 physical physical JJ cord-023865-6rafp3x3 95 30 presence presence NN cord-023865-6rafp3x3 95 31 of of IN cord-023865-6rafp3x3 95 32 the the DT cord-023865-6rafp3x3 95 33 N n NN cord-023865-6rafp3x3 95 34 - - HYPH cord-023865-6rafp3x3 95 35 protein protein NN cord-023865-6rafp3x3 95 36 in in IN cord-023865-6rafp3x3 95 37 the the DT cord-023865-6rafp3x3 95 38 nucleus nucleus NN cord-023865-6rafp3x3 95 39 , , , cord-023865-6rafp3x3 95 40 under under IN cord-023865-6rafp3x3 95 41 certain certain JJ cord-023865-6rafp3x3 95 42 circumstances circumstance NNS cord-023865-6rafp3x3 95 43 , , , cord-023865-6rafp3x3 95 44 which which WDT cord-023865-6rafp3x3 95 45 may may MD cord-023865-6rafp3x3 95 46 be be VB cord-023865-6rafp3x3 95 47 a a DT cord-023865-6rafp3x3 95 48 very very RB cord-023865-6rafp3x3 95 49 dynamic dynamic JJ cord-023865-6rafp3x3 95 50 phenomenon phenomenon NN cord-023865-6rafp3x3 95 51 . . . cord-023865-6rafp3x3 96 1 Another another DT cord-023865-6rafp3x3 96 2 study study NN cord-023865-6rafp3x3 96 3 done do VBN cord-023865-6rafp3x3 96 4 by by IN cord-023865-6rafp3x3 96 5 Timani Timani NNP cord-023865-6rafp3x3 96 6 et et NNP cord-023865-6rafp3x3 96 7 al al NNP cord-023865-6rafp3x3 96 8 . . . cord-023865-6rafp3x3 97 1 ( ( -LRB- cord-023865-6rafp3x3 97 2 2005 2005 CD cord-023865-6rafp3x3 97 3 ) ) -RRB- cord-023865-6rafp3x3 97 4 using use VBG cord-023865-6rafp3x3 97 5 different different JJ cord-023865-6rafp3x3 97 6 deletion deletion NN cord-023865-6rafp3x3 97 7 mutants mutant NNS cord-023865-6rafp3x3 97 8 of of IN cord-023865-6rafp3x3 97 9 the the DT cord-023865-6rafp3x3 97 10 N n CD cord-023865-6rafp3x3 97 11 - - HYPH cord-023865-6rafp3x3 97 12 protein protein NN cord-023865-6rafp3x3 97 13 fused fuse VBD cord-023865-6rafp3x3 97 14 to to IN cord-023865-6rafp3x3 97 15 EGFP EGFP NNP cord-023865-6rafp3x3 97 16 showed show VBD cord-023865-6rafp3x3 97 17 that that IN cord-023865-6rafp3x3 97 18 the the DT cord-023865-6rafp3x3 97 19 N n CD cord-023865-6rafp3x3 97 20 - - HYPH cord-023865-6rafp3x3 97 21 terminal terminal NN cord-023865-6rafp3x3 97 22 of of IN cord-023865-6rafp3x3 97 23 N n NN cord-023865-6rafp3x3 97 24 - - HYPH cord-023865-6rafp3x3 97 25 protein protein NN cord-023865-6rafp3x3 97 26 , , , cord-023865-6rafp3x3 97 27 which which WDT cord-023865-6rafp3x3 97 28 contains contain VBZ cord-023865-6rafp3x3 97 29 the the DT cord-023865-6rafp3x3 97 30 NLS NLS NNP cord-023865-6rafp3x3 97 31 1 1 CD cord-023865-6rafp3x3 97 32 ( ( -LRB- cord-023865-6rafp3x3 97 33 aa aa NNP cord-023865-6rafp3x3 97 34 38 38 CD cord-023865-6rafp3x3 97 35 - - HYPH cord-023865-6rafp3x3 97 36 44 44 CD cord-023865-6rafp3x3 97 37 ) ) -RRB- cord-023865-6rafp3x3 97 38 , , , cord-023865-6rafp3x3 97 39 localizes localize VBZ cord-023865-6rafp3x3 97 40 to to IN cord-023865-6rafp3x3 97 41 the the DT cord-023865-6rafp3x3 97 42 nucleus nucleus NN cord-023865-6rafp3x3 97 43 , , , cord-023865-6rafp3x3 97 44 whereas whereas IN cord-023865-6rafp3x3 97 45 the the DT cord-023865-6rafp3x3 97 46 C C NNP cord-023865-6rafp3x3 97 47 - - HYPH cord-023865-6rafp3x3 97 48 terminal terminal NN cord-023865-6rafp3x3 97 49 region region NN cord-023865-6rafp3x3 97 50 containing contain VBG cord-023865-6rafp3x3 97 51 both both CC cord-023865-6rafp3x3 97 52 NLS NLS NNP cord-023865-6rafp3x3 97 53 2 2 CD cord-023865-6rafp3x3 98 1 ( ( -LRB- cord-023865-6rafp3x3 98 2 aa aa NNP cord-023865-6rafp3x3 98 3 257 257 CD cord-023865-6rafp3x3 98 4 - - HYPH cord-023865-6rafp3x3 98 5 265 265 CD cord-023865-6rafp3x3 98 6 ) ) -RRB- cord-023865-6rafp3x3 98 7 and and CC cord-023865-6rafp3x3 98 8 NLS NLS NNP cord-023865-6rafp3x3 98 9 3 3 CD cord-023865-6rafp3x3 98 10 ( ( -LRB- cord-023865-6rafp3x3 98 11 aa aa NNP cord-023865-6rafp3x3 98 12 369 369 CD cord-023865-6rafp3x3 98 13 - - HYPH cord-023865-6rafp3x3 98 14 390 390 CD cord-023865-6rafp3x3 98 15 ) ) -RRB- cord-023865-6rafp3x3 98 16 localizes localize VBZ cord-023865-6rafp3x3 98 17 to to IN cord-023865-6rafp3x3 98 18 the the DT cord-023865-6rafp3x3 98 19 cytoplasm cytoplasm NN cord-023865-6rafp3x3 98 20 and and CC cord-023865-6rafp3x3 98 21 nucleolus nucleolus NN cord-023865-6rafp3x3 98 22 . . . cord-023865-6rafp3x3 99 1 Using use VBG cord-023865-6rafp3x3 99 2 a a DT cord-023865-6rafp3x3 99 3 combination combination NN cord-023865-6rafp3x3 99 4 of of IN cord-023865-6rafp3x3 99 5 different different JJ cord-023865-6rafp3x3 99 6 deletion deletion NN cord-023865-6rafp3x3 99 7 mutants mutant NNS cord-023865-6rafp3x3 99 8 , , , cord-023865-6rafp3x3 99 9 they -PRON- PRP cord-023865-6rafp3x3 99 10 concluded conclude VBD cord-023865-6rafp3x3 99 11 that that IN cord-023865-6rafp3x3 99 12 the the DT cord-023865-6rafp3x3 99 13 N N NNP cord-023865-6rafp3x3 99 14 - - HYPH cord-023865-6rafp3x3 99 15 protein protein NN cord-023865-6rafp3x3 99 16 may may MD cord-023865-6rafp3x3 99 17 act act VB cord-023865-6rafp3x3 99 18 as as IN cord-023865-6rafp3x3 99 19 a a DT cord-023865-6rafp3x3 99 20 shuttle shuttle NN cord-023865-6rafp3x3 99 21 protein protein NN cord-023865-6rafp3x3 99 22 between between IN cord-023865-6rafp3x3 99 23 cytoplasm cytoplasm NN cord-023865-6rafp3x3 99 24 - - HYPH cord-023865-6rafp3x3 99 25 nucleus nucleus NN cord-023865-6rafp3x3 99 26 and and CC cord-023865-6rafp3x3 99 27 nucleolus nucleolus NN cord-023865-6rafp3x3 99 28 . . . cord-023865-6rafp3x3 100 1 Taken take VBN cord-023865-6rafp3x3 100 2 together together RB cord-023865-6rafp3x3 100 3 , , , cord-023865-6rafp3x3 100 4 all all PDT cord-023865-6rafp3x3 100 5 these these DT cord-023865-6rafp3x3 100 6 results result NNS cord-023865-6rafp3x3 100 7 further further RB cord-023865-6rafp3x3 100 8 suggest suggest VBP cord-023865-6rafp3x3 100 9 that that IN cord-023865-6rafp3x3 100 10 the the DT cord-023865-6rafp3x3 100 11 N n NN cord-023865-6rafp3x3 100 12 - - HYPH cord-023865-6rafp3x3 100 13 protein protein NN cord-023865-6rafp3x3 100 14 per per FW cord-023865-6rafp3x3 100 15 se se FW cord-023865-6rafp3x3 100 16 has have VBZ cord-023865-6rafp3x3 100 17 the the DT cord-023865-6rafp3x3 100 18 physical physical JJ cord-023865-6rafp3x3 100 19 ability ability NN cord-023865-6rafp3x3 100 20 to to TO cord-023865-6rafp3x3 100 21 localize localize VB cord-023865-6rafp3x3 100 22 to to IN cord-023865-6rafp3x3 100 23 the the DT cord-023865-6rafp3x3 100 24 nucleus nucleus NN cord-023865-6rafp3x3 100 25 . . . cord-023865-6rafp3x3 101 1 Whether whether IN cord-023865-6rafp3x3 101 2 this this DT cord-023865-6rafp3x3 101 3 localization localization NN cord-023865-6rafp3x3 101 4 is be VBZ cord-023865-6rafp3x3 101 5 regulated regulate VBN cord-023865-6rafp3x3 101 6 through through IN cord-023865-6rafp3x3 101 7 phosphorylation phosphorylation NN cord-023865-6rafp3x3 101 8 - - HYPH cord-023865-6rafp3x3 101 9 mediated mediate VBN cord-023865-6rafp3x3 101 10 activation activation NN cord-023865-6rafp3x3 101 11 of of IN cord-023865-6rafp3x3 101 12 a a DT cord-023865-6rafp3x3 101 13 potential potential JJ cord-023865-6rafp3x3 101 14 NLS nls NN cord-023865-6rafp3x3 101 15 or or CC cord-023865-6rafp3x3 101 16 piggy piggy NN cord-023865-6rafp3x3 101 17 - - HYPH cord-023865-6rafp3x3 101 18 backing backing NN cord-023865-6rafp3x3 101 19 by by IN cord-023865-6rafp3x3 101 20 association association NN cord-023865-6rafp3x3 101 21 with with IN cord-023865-6rafp3x3 101 22 another another DT cord-023865-6rafp3x3 101 23 cellular cellular JJ cord-023865-6rafp3x3 101 24 nuclear nuclear JJ cord-023865-6rafp3x3 101 25 protein protein NN cord-023865-6rafp3x3 101 26 or or CC cord-023865-6rafp3x3 101 27 through through IN cord-023865-6rafp3x3 101 28 any any DT cord-023865-6rafp3x3 101 29 other other JJ cord-023865-6rafp3x3 101 30 mechanism mechanism NN cord-023865-6rafp3x3 101 31 remains remain VBZ cord-023865-6rafp3x3 101 32 to to TO cord-023865-6rafp3x3 101 33 be be VB cord-023865-6rafp3x3 101 34 established establish VBN cord-023865-6rafp3x3 101 35 . . . cord-023865-6rafp3x3 102 1 Being be VBG cord-023865-6rafp3x3 102 2 the the DT cord-023865-6rafp3x3 102 3 capsid capsid NN cord-023865-6rafp3x3 102 4 protein protein NN cord-023865-6rafp3x3 102 5 , , , cord-023865-6rafp3x3 102 6 the the DT cord-023865-6rafp3x3 102 7 primary primary JJ cord-023865-6rafp3x3 102 8 function function NN cord-023865-6rafp3x3 102 9 of of IN cord-023865-6rafp3x3 102 10 the the DT cord-023865-6rafp3x3 102 11 N n CD cord-023865-6rafp3x3 102 12 - - HYPH cord-023865-6rafp3x3 102 13 protein protein NN cord-023865-6rafp3x3 102 14 is be VBZ cord-023865-6rafp3x3 102 15 to to TO cord-023865-6rafp3x3 102 16 package package VB cord-023865-6rafp3x3 102 17 the the DT cord-023865-6rafp3x3 102 18 genomic genomic JJ cord-023865-6rafp3x3 102 19 RNA rna NN cord-023865-6rafp3x3 102 20 in in IN cord-023865-6rafp3x3 102 21 a a DT cord-023865-6rafp3x3 102 22 protective protective JJ cord-023865-6rafp3x3 102 23 covering covering NN cord-023865-6rafp3x3 102 24 . . . cord-023865-6rafp3x3 103 1 In in IN cord-023865-6rafp3x3 103 2 order order NN cord-023865-6rafp3x3 103 3 to to TO cord-023865-6rafp3x3 103 4 achieve achieve VB cord-023865-6rafp3x3 103 5 this this DT cord-023865-6rafp3x3 103 6 structure structure NN cord-023865-6rafp3x3 103 7 , , , cord-023865-6rafp3x3 103 8 the the DT cord-023865-6rafp3x3 103 9 N N NNP cord-023865-6rafp3x3 103 10 - - HYPH cord-023865-6rafp3x3 103 11 protein protein NN cord-023865-6rafp3x3 103 12 must must MD cord-023865-6rafp3x3 103 13 be be VB cord-023865-6rafp3x3 103 14 equipped equip VBN cord-023865-6rafp3x3 103 15 with with IN cord-023865-6rafp3x3 103 16 two two CD cord-023865-6rafp3x3 103 17 different different JJ cord-023865-6rafp3x3 103 18 characteristic characteristic JJ cord-023865-6rafp3x3 103 19 properties property NNS cord-023865-6rafp3x3 103 20 ; ; , cord-023865-6rafp3x3 103 21 such such JJ cord-023865-6rafp3x3 103 22 as as IN cord-023865-6rafp3x3 103 23 ( ( -LRB- cord-023865-6rafp3x3 103 24 1 1 CD cord-023865-6rafp3x3 103 25 ) ) -RRB- cord-023865-6rafp3x3 103 26 being be VBG cord-023865-6rafp3x3 103 27 able able JJ cord-023865-6rafp3x3 103 28 to to TO cord-023865-6rafp3x3 103 29 recognize recognize VB cord-023865-6rafp3x3 103 30 the the DT cord-023865-6rafp3x3 103 31 genomic genomic JJ cord-023865-6rafp3x3 103 32 RNA RNA NNP cord-023865-6rafp3x3 103 33 and and CC cord-023865-6rafp3x3 103 34 associate associate VB cord-023865-6rafp3x3 103 35 with with IN cord-023865-6rafp3x3 103 36 it -PRON- PRP cord-023865-6rafp3x3 103 37 , , , cord-023865-6rafp3x3 103 38 and and CC cord-023865-6rafp3x3 103 39 ( ( -LRB- cord-023865-6rafp3x3 103 40 2 2 LS cord-023865-6rafp3x3 103 41 ) ) -RRB- cord-023865-6rafp3x3 103 42 selfassociate selfassociate NN cord-023865-6rafp3x3 103 43 into into IN cord-023865-6rafp3x3 103 44 an an DT cord-023865-6rafp3x3 103 45 oligomer oligomer NN cord-023865-6rafp3x3 103 46 to to TO cord-023865-6rafp3x3 103 47 form form VB cord-023865-6rafp3x3 103 48 the the DT cord-023865-6rafp3x3 103 49 capsid capsid NN cord-023865-6rafp3x3 103 50 . . . cord-023865-6rafp3x3 104 1 The the DT cord-023865-6rafp3x3 104 2 N n NN cord-023865-6rafp3x3 104 3 - - HYPH cord-023865-6rafp3x3 104 4 protein protein NN cord-023865-6rafp3x3 104 5 of of IN cord-023865-6rafp3x3 104 6 SARS SARS NNP cord-023865-6rafp3x3 104 7 - - HYPH cord-023865-6rafp3x3 104 8 CoV CoV NNP cord-023865-6rafp3x3 104 9 has have VBZ cord-023865-6rafp3x3 104 10 been be VBN cord-023865-6rafp3x3 104 11 experimentally experimentally RB cord-023865-6rafp3x3 104 12 proven prove VBN cord-023865-6rafp3x3 104 13 to to TO cord-023865-6rafp3x3 104 14 possess possess VB cord-023865-6rafp3x3 104 15 these these DT cord-023865-6rafp3x3 104 16 properties property NNS cord-023865-6rafp3x3 104 17 in in IN cord-023865-6rafp3x3 104 18 vitro vitro FW cord-023865-6rafp3x3 104 19 , , , cord-023865-6rafp3x3 104 20 as as IN cord-023865-6rafp3x3 104 21 discussed discuss VBN cord-023865-6rafp3x3 104 22 below below RB cord-023865-6rafp3x3 104 23 . . . cord-023865-6rafp3x3 105 1 9.6.1 9.6.1 CD cord-023865-6rafp3x3 105 2 Recognition Recognition NNP cord-023865-6rafp3x3 105 3 and and CC cord-023865-6rafp3x3 105 4 Binding Binding NNP cord-023865-6rafp3x3 105 5 with with IN cord-023865-6rafp3x3 105 6 the the DT cord-023865-6rafp3x3 105 7 Genomic Genomic NNP cord-023865-6rafp3x3 105 8 RNA RNA NNP cord-023865-6rafp3x3 106 1 The the DT cord-023865-6rafp3x3 106 2 first first JJ cord-023865-6rafp3x3 106 3 experimental experimental JJ cord-023865-6rafp3x3 106 4 evidence evidence NN cord-023865-6rafp3x3 106 5 regarding regard VBG cord-023865-6rafp3x3 106 6 the the DT cord-023865-6rafp3x3 106 7 RNA RNA NNP cord-023865-6rafp3x3 106 8 binding bind VBG cord-023865-6rafp3x3 106 9 property property NN cord-023865-6rafp3x3 106 10 of of IN cord-023865-6rafp3x3 106 11 the the DT cord-023865-6rafp3x3 106 12 N N NNP cord-023865-6rafp3x3 106 13 - - HYPH cord-023865-6rafp3x3 106 14 protein protein NN cord-023865-6rafp3x3 106 15 came come VBD cord-023865-6rafp3x3 106 16 from from IN cord-023865-6rafp3x3 106 17 the the DT cord-023865-6rafp3x3 106 18 work work NN cord-023865-6rafp3x3 106 19 of of IN cord-023865-6rafp3x3 106 20 Huang Huang NNP cord-023865-6rafp3x3 106 21 et et FW cord-023865-6rafp3x3 106 22 al al NNP cord-023865-6rafp3x3 106 23 . . . cord-023865-6rafp3x3 107 1 ( ( -LRB- cord-023865-6rafp3x3 107 2 2004 2004 CD cord-023865-6rafp3x3 107 3 ) ) -RRB- cord-023865-6rafp3x3 107 4 , , , cord-023865-6rafp3x3 107 5 in in IN cord-023865-6rafp3x3 107 6 which which WDT cord-023865-6rafp3x3 107 7 , , , cord-023865-6rafp3x3 107 8 by by IN cord-023865-6rafp3x3 107 9 NMR NMR NNP cord-023865-6rafp3x3 107 10 studies study NNS cord-023865-6rafp3x3 107 11 , , , cord-023865-6rafp3x3 107 12 they -PRON- PRP cord-023865-6rafp3x3 107 13 proved prove VBD cord-023865-6rafp3x3 107 14 the the DT cord-023865-6rafp3x3 107 15 ability ability NN cord-023865-6rafp3x3 107 16 of of IN cord-023865-6rafp3x3 107 17 the the DT cord-023865-6rafp3x3 107 18 N n CD cord-023865-6rafp3x3 107 19 - - HYPH cord-023865-6rafp3x3 107 20 terminal terminal NN cord-023865-6rafp3x3 107 21 domain domain NN cord-023865-6rafp3x3 107 22 to to TO cord-023865-6rafp3x3 107 23 associate associate VB cord-023865-6rafp3x3 107 24 with with IN cord-023865-6rafp3x3 107 25 several several JJ cord-023865-6rafp3x3 107 26 viral viral JJ cord-023865-6rafp3x3 107 27 3 3 CD cord-023865-6rafp3x3 107 28 0 0 CD cord-023865-6rafp3x3 107 29 untranslated untranslated JJ cord-023865-6rafp3x3 107 30 RNA RNA NNP cord-023865-6rafp3x3 107 31 sequences sequence NNS cord-023865-6rafp3x3 107 32 . . . cord-023865-6rafp3x3 108 1 Additionally additionally RB cord-023865-6rafp3x3 108 2 , , , cord-023865-6rafp3x3 108 3 Chen Chen NNP cord-023865-6rafp3x3 108 4 et et NNP cord-023865-6rafp3x3 108 5 al al NNP cord-023865-6rafp3x3 108 6 . . . cord-023865-6rafp3x3 109 1 ( ( -LRB- cord-023865-6rafp3x3 109 2 2007 2007 CD cord-023865-6rafp3x3 109 3 ) ) -RRB- cord-023865-6rafp3x3 109 4 reported report VBD cord-023865-6rafp3x3 109 5 the the DT cord-023865-6rafp3x3 109 6 presence presence NN cord-023865-6rafp3x3 109 7 of of IN cord-023865-6rafp3x3 109 8 another another DT cord-023865-6rafp3x3 109 9 RNA RNA NNP cord-023865-6rafp3x3 109 10 binding binding NN cord-023865-6rafp3x3 109 11 domain domain NN cord-023865-6rafp3x3 109 12 at at IN cord-023865-6rafp3x3 109 13 the the DT cord-023865-6rafp3x3 109 14 C C NNP cord-023865-6rafp3x3 109 15 - - HYPH cord-023865-6rafp3x3 109 16 terminal terminal NN cord-023865-6rafp3x3 109 17 region region NN cord-023865-6rafp3x3 109 18 ( ( -LRB- cord-023865-6rafp3x3 109 19 residues residue NNS cord-023865-6rafp3x3 109 20 248 248 CD cord-023865-6rafp3x3 109 21 - - HYPH cord-023865-6rafp3x3 109 22 365 365 CD cord-023865-6rafp3x3 109 23 ) ) -RRB- cord-023865-6rafp3x3 109 24 of of IN cord-023865-6rafp3x3 109 25 the the DT cord-023865-6rafp3x3 109 26 N N NNP cord-023865-6rafp3x3 109 27 - - HYPH cord-023865-6rafp3x3 109 28 protein protein NN cord-023865-6rafp3x3 109 29 , , , cord-023865-6rafp3x3 109 30 which which WDT cord-023865-6rafp3x3 109 31 was be VBD cord-023865-6rafp3x3 109 32 proposed propose VBN cord-023865-6rafp3x3 109 33 to to TO cord-023865-6rafp3x3 109 34 be be VB cord-023865-6rafp3x3 109 35 a a DT cord-023865-6rafp3x3 109 36 stronger strong JJR cord-023865-6rafp3x3 109 37 interaction interaction NN cord-023865-6rafp3x3 109 38 than than IN cord-023865-6rafp3x3 109 39 that that DT cord-023865-6rafp3x3 109 40 at at IN cord-023865-6rafp3x3 109 41 the the DT cord-023865-6rafp3x3 109 42 N n CD cord-023865-6rafp3x3 109 43 terminus terminus NN cord-023865-6rafp3x3 109 44 . . . cord-023865-6rafp3x3 110 1 Based base VBN cord-023865-6rafp3x3 110 2 on on IN cord-023865-6rafp3x3 110 3 structural structural JJ cord-023865-6rafp3x3 110 4 analysis analysis NN cord-023865-6rafp3x3 110 5 of of IN cord-023865-6rafp3x3 110 6 the the DT cord-023865-6rafp3x3 110 7 RNA RNA NNP cord-023865-6rafp3x3 110 8 - - HYPH cord-023865-6rafp3x3 110 9 protein protein NN cord-023865-6rafp3x3 110 10 interaction interaction NN cord-023865-6rafp3x3 110 11 , , , cord-023865-6rafp3x3 110 12 they -PRON- PRP cord-023865-6rafp3x3 110 13 have have VBP cord-023865-6rafp3x3 110 14 further further RB cord-023865-6rafp3x3 110 15 suggested suggest VBN cord-023865-6rafp3x3 110 16 that that IN cord-023865-6rafp3x3 110 17 the the DT cord-023865-6rafp3x3 110 18 genomic genomic JJ cord-023865-6rafp3x3 110 19 RNA RNA NNP cord-023865-6rafp3x3 110 20 is be VBZ cord-023865-6rafp3x3 110 21 packaged package VBN cord-023865-6rafp3x3 110 22 in in IN cord-023865-6rafp3x3 110 23 a a DT cord-023865-6rafp3x3 110 24 helical helical JJ cord-023865-6rafp3x3 110 25 manner manner NN cord-023865-6rafp3x3 110 26 by by IN cord-023865-6rafp3x3 110 27 the the DT cord-023865-6rafp3x3 110 28 N N NNP cord-023865-6rafp3x3 110 29 - - HYPH cord-023865-6rafp3x3 110 30 protein protein NN cord-023865-6rafp3x3 110 31 . . . cord-023865-6rafp3x3 111 1 In in IN cord-023865-6rafp3x3 111 2 another another DT cord-023865-6rafp3x3 111 3 report report NN cord-023865-6rafp3x3 111 4 published publish VBN cord-023865-6rafp3x3 111 5 by by IN cord-023865-6rafp3x3 111 6 Luo Luo NNP cord-023865-6rafp3x3 111 7 et et NNP cord-023865-6rafp3x3 111 8 al al NNP cord-023865-6rafp3x3 111 9 . . . cord-023865-6rafp3x3 112 1 ( ( -LRB- cord-023865-6rafp3x3 112 2 2006 2006 CD cord-023865-6rafp3x3 112 3 ) ) -RRB- cord-023865-6rafp3x3 112 4 , , , cord-023865-6rafp3x3 112 5 the the DT cord-023865-6rafp3x3 112 6 RNA RNA NNP cord-023865-6rafp3x3 112 7 binding binding NN cord-023865-6rafp3x3 112 8 motif motif NN cord-023865-6rafp3x3 112 9 of of IN cord-023865-6rafp3x3 112 10 the the DT cord-023865-6rafp3x3 112 11 N N NNP cord-023865-6rafp3x3 112 12 - - HYPH cord-023865-6rafp3x3 112 13 protein protein NN cord-023865-6rafp3x3 112 14 was be VBD cord-023865-6rafp3x3 112 15 mapped map VBN cord-023865-6rafp3x3 112 16 to to IN cord-023865-6rafp3x3 112 17 amino amino NN cord-023865-6rafp3x3 112 18 acid acid NN cord-023865-6rafp3x3 112 19 residues residue NNS cord-023865-6rafp3x3 112 20 363 363 CD cord-023865-6rafp3x3 112 21 - - SYM cord-023865-6rafp3x3 112 22 382 382 CD cord-023865-6rafp3x3 112 23 . . . cord-023865-6rafp3x3 113 1 In in IN cord-023865-6rafp3x3 113 2 summary summary NN cord-023865-6rafp3x3 113 3 , , , cord-023865-6rafp3x3 113 4 the the DT cord-023865-6rafp3x3 113 5 RNA RNA NNP cord-023865-6rafp3x3 113 6 binding bind VBG cord-023865-6rafp3x3 113 7 ability ability NN cord-023865-6rafp3x3 113 8 of of IN cord-023865-6rafp3x3 113 9 the the DT cord-023865-6rafp3x3 113 10 N N NNP cord-023865-6rafp3x3 113 11 - - HYPH cord-023865-6rafp3x3 113 12 protein protein NN cord-023865-6rafp3x3 113 13 was be VBD cord-023865-6rafp3x3 113 14 attributed attribute VBN cord-023865-6rafp3x3 113 15 to to IN cord-023865-6rafp3x3 113 16 its -PRON- PRP$ cord-023865-6rafp3x3 113 17 two two CD cord-023865-6rafp3x3 113 18 distinct distinct JJ cord-023865-6rafp3x3 113 19 structural structural JJ cord-023865-6rafp3x3 113 20 domains domain NNS cord-023865-6rafp3x3 113 21 : : : cord-023865-6rafp3x3 113 22 the the DT cord-023865-6rafp3x3 113 23 N n CD cord-023865-6rafp3x3 113 24 - - HYPH cord-023865-6rafp3x3 113 25 terminal terminal NN cord-023865-6rafp3x3 113 26 domain domain NN cord-023865-6rafp3x3 113 27 ( ( -LRB- cord-023865-6rafp3x3 113 28 residues residue NNS cord-023865-6rafp3x3 113 29 45 45 CD cord-023865-6rafp3x3 113 30 - - SYM cord-023865-6rafp3x3 113 31 181 181 CD cord-023865-6rafp3x3 113 32 ) ) -RRB- cord-023865-6rafp3x3 113 33 and and CC cord-023865-6rafp3x3 113 34 the the DT cord-023865-6rafp3x3 113 35 C C NNP cord-023865-6rafp3x3 113 36 - - HYPH cord-023865-6rafp3x3 113 37 terminal terminal NN cord-023865-6rafp3x3 113 38 dimerization dimerization NN cord-023865-6rafp3x3 113 39 domain domain NN cord-023865-6rafp3x3 113 40 ( ( -LRB- cord-023865-6rafp3x3 113 41 residues residue NNS cord-023865-6rafp3x3 113 42 248 248 CD cord-023865-6rafp3x3 113 43 - - HYPH cord-023865-6rafp3x3 113 44 365 365 CD cord-023865-6rafp3x3 113 45 ) ) -RRB- cord-023865-6rafp3x3 113 46 . . . cord-023865-6rafp3x3 114 1 These these DT cord-023865-6rafp3x3 114 2 two two CD cord-023865-6rafp3x3 114 3 domains domain NNS cord-023865-6rafp3x3 114 4 are be VBP cord-023865-6rafp3x3 114 5 spatially spatially RB cord-023865-6rafp3x3 114 6 separated separate VBN cord-023865-6rafp3x3 114 7 by by IN cord-023865-6rafp3x3 114 8 long long JJ cord-023865-6rafp3x3 114 9 stretches stretch NNS cord-023865-6rafp3x3 114 10 of of IN cord-023865-6rafp3x3 114 11 disordered disordered JJ cord-023865-6rafp3x3 114 12 region region NN cord-023865-6rafp3x3 114 13 . . . cord-023865-6rafp3x3 115 1 A a DT cord-023865-6rafp3x3 115 2 recent recent JJ cord-023865-6rafp3x3 115 3 study study NN cord-023865-6rafp3x3 115 4 done do VBN cord-023865-6rafp3x3 115 5 by by IN cord-023865-6rafp3x3 115 6 Chang Chang NNP cord-023865-6rafp3x3 115 7 et et NNP cord-023865-6rafp3x3 115 8 al al NNP cord-023865-6rafp3x3 115 9 . . . cord-023865-6rafp3x3 116 1 ( ( -LRB- cord-023865-6rafp3x3 116 2 2008 2008 CD cord-023865-6rafp3x3 116 3 ) ) -RRB- cord-023865-6rafp3x3 116 4 has have VBZ cord-023865-6rafp3x3 116 5 demonstrated demonstrate VBN cord-023865-6rafp3x3 116 6 RNA RNA NNP cord-023865-6rafp3x3 116 7 binding bind VBG cord-023865-6rafp3x3 116 8 ability ability NN cord-023865-6rafp3x3 116 9 of of IN cord-023865-6rafp3x3 116 10 these these DT cord-023865-6rafp3x3 116 11 disordered disordered JJ cord-023865-6rafp3x3 116 12 regions region NNS cord-023865-6rafp3x3 116 13 . . . cord-023865-6rafp3x3 117 1 They -PRON- PRP cord-023865-6rafp3x3 117 2 have have VBP cord-023865-6rafp3x3 117 3 proposed propose VBN cord-023865-6rafp3x3 117 4 that that IN cord-023865-6rafp3x3 117 5 different different JJ cord-023865-6rafp3x3 117 6 RNA RNA NNP cord-023865-6rafp3x3 117 7 binding bind VBG cord-023865-6rafp3x3 117 8 domains domain NNS cord-023865-6rafp3x3 117 9 of of IN cord-023865-6rafp3x3 117 10 the the DT cord-023865-6rafp3x3 117 11 N n NN cord-023865-6rafp3x3 117 12 - - HYPH cord-023865-6rafp3x3 117 13 protein protein NN cord-023865-6rafp3x3 117 14 may may MD cord-023865-6rafp3x3 117 15 cooperate cooperate VB cord-023865-6rafp3x3 117 16 to to TO cord-023865-6rafp3x3 117 17 enhance enhance VB cord-023865-6rafp3x3 117 18 the the DT cord-023865-6rafp3x3 117 19 overall overall JJ cord-023865-6rafp3x3 117 20 RNA RNA NNP cord-023865-6rafp3x3 117 21 binding bind VBG cord-023865-6rafp3x3 117 22 efficiency efficiency NN cord-023865-6rafp3x3 117 23 of of IN cord-023865-6rafp3x3 117 24 the the DT cord-023865-6rafp3x3 117 25 N n NN cord-023865-6rafp3x3 117 26 - - HYPH cord-023865-6rafp3x3 117 27 protein protein NN cord-023865-6rafp3x3 117 28 and and CC cord-023865-6rafp3x3 117 29 may may MD cord-023865-6rafp3x3 117 30 also also RB cord-023865-6rafp3x3 117 31 serve serve VB cord-023865-6rafp3x3 117 32 as as IN cord-023865-6rafp3x3 117 33 interaction interaction NN cord-023865-6rafp3x3 117 34 hubs hub NNS cord-023865-6rafp3x3 117 35 for for IN cord-023865-6rafp3x3 117 36 the the DT cord-023865-6rafp3x3 117 37 association association NN cord-023865-6rafp3x3 117 38 of of IN cord-023865-6rafp3x3 117 39 N N NNP cord-023865-6rafp3x3 117 40 - - HYPH cord-023865-6rafp3x3 117 41 protein protein NN cord-023865-6rafp3x3 117 42 with with IN cord-023865-6rafp3x3 117 43 other other JJ cord-023865-6rafp3x3 117 44 viral viral NN cord-023865-6rafp3x3 117 45 and/or and/or CC cord-023865-6rafp3x3 117 46 host host NN cord-023865-6rafp3x3 117 47 nucleic nucleic JJ cord-023865-6rafp3x3 117 48 acid acid NN cord-023865-6rafp3x3 117 49 and/or and/or CC cord-023865-6rafp3x3 117 50 proteins protein NNS cord-023865-6rafp3x3 117 51 . . . cord-023865-6rafp3x3 118 1 Perhaps perhaps RB cord-023865-6rafp3x3 118 2 the the DT cord-023865-6rafp3x3 118 3 most most RBS cord-023865-6rafp3x3 118 4 convincing convincing JJ cord-023865-6rafp3x3 118 5 proof proof NN cord-023865-6rafp3x3 118 6 to to IN cord-023865-6rafp3x3 118 7 date date NN cord-023865-6rafp3x3 118 8 regarding regard VBG cord-023865-6rafp3x3 118 9 the the DT cord-023865-6rafp3x3 118 10 ability ability NN cord-023865-6rafp3x3 118 11 of of IN cord-023865-6rafp3x3 118 12 the the DT cord-023865-6rafp3x3 118 13 N n NN cord-023865-6rafp3x3 118 14 - - HYPH cord-023865-6rafp3x3 118 15 protein protein NN cord-023865-6rafp3x3 118 16 to to TO cord-023865-6rafp3x3 118 17 package package VB cord-023865-6rafp3x3 118 18 the the DT cord-023865-6rafp3x3 118 19 genomic genomic JJ cord-023865-6rafp3x3 118 20 RNA RNA NNP cord-023865-6rafp3x3 118 21 came come VBD cord-023865-6rafp3x3 118 22 from from IN cord-023865-6rafp3x3 118 23 the the DT cord-023865-6rafp3x3 118 24 work work NN cord-023865-6rafp3x3 118 25 of of IN cord-023865-6rafp3x3 118 26 Hsieh Hsieh NNP cord-023865-6rafp3x3 118 27 et et NNP cord-023865-6rafp3x3 118 28 al al NNP cord-023865-6rafp3x3 118 29 . . . cord-023865-6rafp3x3 119 1 ( ( -LRB- cord-023865-6rafp3x3 119 2 2005 2005 CD cord-023865-6rafp3x3 119 3 ) ) -RRB- cord-023865-6rafp3x3 119 4 . . . cord-023865-6rafp3x3 120 1 They -PRON- PRP cord-023865-6rafp3x3 120 2 have have VBP cord-023865-6rafp3x3 120 3 established establish VBN cord-023865-6rafp3x3 120 4 a a DT cord-023865-6rafp3x3 120 5 system system NN cord-023865-6rafp3x3 120 6 to to TO cord-023865-6rafp3x3 120 7 produce produce VB cord-023865-6rafp3x3 120 8 SARS SARS NNP cord-023865-6rafp3x3 120 9 - - HYPH cord-023865-6rafp3x3 120 10 CoV CoV NNP cord-023865-6rafp3x3 120 11 VLPs vlp NNS cord-023865-6rafp3x3 120 12 by by IN cord-023865-6rafp3x3 120 13 cotransfection cotransfection NN cord-023865-6rafp3x3 120 14 of of IN cord-023865-6rafp3x3 120 15 spike spike NN cord-023865-6rafp3x3 120 16 , , , cord-023865-6rafp3x3 120 17 membrane membrane NN cord-023865-6rafp3x3 120 18 , , , cord-023865-6rafp3x3 120 19 and and CC cord-023865-6rafp3x3 120 20 envelope envelope NN cord-023865-6rafp3x3 120 21 and and CC cord-023865-6rafp3x3 120 22 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 120 23 cDNAs cdna VBZ cord-023865-6rafp3x3 120 24 into into IN cord-023865-6rafp3x3 120 25 Vero Vero NNP cord-023865-6rafp3x3 120 26 E6 E6 NNP cord-023865-6rafp3x3 120 27 cells cell NNS cord-023865-6rafp3x3 120 28 . . . cord-023865-6rafp3x3 121 1 While while IN cord-023865-6rafp3x3 121 2 testing test VBG cord-023865-6rafp3x3 121 3 the the DT cord-023865-6rafp3x3 121 4 packaging packaging NN cord-023865-6rafp3x3 121 5 of of IN cord-023865-6rafp3x3 121 6 an an DT cord-023865-6rafp3x3 121 7 RNA RNA NNP cord-023865-6rafp3x3 121 8 - - HYPH cord-023865-6rafp3x3 121 9 bearing bear VBG cord-023865-6rafp3x3 121 10 GFP GFP NNP cord-023865-6rafp3x3 121 11 fused fuse VBN cord-023865-6rafp3x3 121 12 to to IN cord-023865-6rafp3x3 121 13 SARS SARS NNP cord-023865-6rafp3x3 121 14 - - HYPH cord-023865-6rafp3x3 121 15 CoV CoV NNP cord-023865-6rafp3x3 121 16 packaging packaging NN cord-023865-6rafp3x3 121 17 signal signal NN cord-023865-6rafp3x3 121 18 into into IN cord-023865-6rafp3x3 121 19 this this DT cord-023865-6rafp3x3 121 20 particle particle NN cord-023865-6rafp3x3 121 21 , , , cord-023865-6rafp3x3 121 22 they -PRON- PRP cord-023865-6rafp3x3 121 23 observed observe VBD cord-023865-6rafp3x3 121 24 that that DT cord-023865-6rafp3x3 121 25 presence presence NN cord-023865-6rafp3x3 121 26 of of IN cord-023865-6rafp3x3 121 27 the the DT cord-023865-6rafp3x3 121 28 N N NNP cord-023865-6rafp3x3 121 29 - - HYPH cord-023865-6rafp3x3 121 30 protein protein NN cord-023865-6rafp3x3 121 31 is be VBZ cord-023865-6rafp3x3 121 32 an an DT cord-023865-6rafp3x3 121 33 absolute absolute JJ cord-023865-6rafp3x3 121 34 requirement requirement NN cord-023865-6rafp3x3 121 35 . . . cord-023865-6rafp3x3 122 1 However however RB cord-023865-6rafp3x3 122 2 , , , cord-023865-6rafp3x3 122 3 the the DT cord-023865-6rafp3x3 122 4 N N NNP cord-023865-6rafp3x3 122 5 - - HYPH cord-023865-6rafp3x3 122 6 protein protein NN cord-023865-6rafp3x3 122 7 was be VBD cord-023865-6rafp3x3 122 8 not not RB cord-023865-6rafp3x3 122 9 essential essential JJ cord-023865-6rafp3x3 122 10 for for IN cord-023865-6rafp3x3 122 11 the the DT cord-023865-6rafp3x3 122 12 assembly assembly NN cord-023865-6rafp3x3 122 13 of of IN cord-023865-6rafp3x3 122 14 the the DT cord-023865-6rafp3x3 122 15 empty empty JJ cord-023865-6rafp3x3 122 16 particle particle NN cord-023865-6rafp3x3 122 17 per per FW cord-023865-6rafp3x3 122 18 se se FW cord-023865-6rafp3x3 122 19 . . . cord-023865-6rafp3x3 123 1 Further further RB cord-023865-6rafp3x3 123 2 , , , cord-023865-6rafp3x3 123 3 by by IN cord-023865-6rafp3x3 123 4 performing perform VBG cord-023865-6rafp3x3 123 5 a a DT cord-023865-6rafp3x3 123 6 filter filter NN cord-023865-6rafp3x3 123 7 binding binding NN cord-023865-6rafp3x3 123 8 assay assay NN cord-023865-6rafp3x3 123 9 using use VBG cord-023865-6rafp3x3 123 10 recombinant recombinant JJ cord-023865-6rafp3x3 123 11 N n NN cord-023865-6rafp3x3 123 12 - - HYPH cord-023865-6rafp3x3 123 13 protein protein NN cord-023865-6rafp3x3 123 14 , , , cord-023865-6rafp3x3 123 15 they -PRON- PRP cord-023865-6rafp3x3 123 16 were be VBD cord-023865-6rafp3x3 123 17 able able JJ cord-023865-6rafp3x3 123 18 to to TO cord-023865-6rafp3x3 123 19 identify identify VB cord-023865-6rafp3x3 123 20 two two CD cord-023865-6rafp3x3 123 21 independent independent JJ cord-023865-6rafp3x3 123 22 RNA RNA NNP cord-023865-6rafp3x3 123 23 binding bind VBG cord-023865-6rafp3x3 123 24 domains domain NNS cord-023865-6rafp3x3 123 25 in in IN cord-023865-6rafp3x3 123 26 the the DT cord-023865-6rafp3x3 123 27 N n NN cord-023865-6rafp3x3 123 28 - - HYPH cord-023865-6rafp3x3 123 29 protein protein NN cord-023865-6rafp3x3 123 30 ; ; : cord-023865-6rafp3x3 123 31 one one CD cord-023865-6rafp3x3 123 32 at at IN cord-023865-6rafp3x3 123 33 the the DT cord-023865-6rafp3x3 123 34 N n CD cord-023865-6rafp3x3 123 35 terminus terminus NN cord-023865-6rafp3x3 123 36 ( ( -LRB- cord-023865-6rafp3x3 123 37 aa aa NNP cord-023865-6rafp3x3 123 38 1 1 NNP cord-023865-6rafp3x3 123 39 - - HYPH cord-023865-6rafp3x3 123 40 235 235 CD cord-023865-6rafp3x3 123 41 ) ) -RRB- cord-023865-6rafp3x3 123 42 and and CC cord-023865-6rafp3x3 123 43 the the DT cord-023865-6rafp3x3 123 44 other other JJ cord-023865-6rafp3x3 123 45 at at IN cord-023865-6rafp3x3 123 46 the the DT cord-023865-6rafp3x3 123 47 C C NNP cord-023865-6rafp3x3 123 48 terminus terminus NN cord-023865-6rafp3x3 124 1 ( ( -LRB- cord-023865-6rafp3x3 124 2 aa aa NNP cord-023865-6rafp3x3 124 3 236 236 CD cord-023865-6rafp3x3 124 4 - - HYPH cord-023865-6rafp3x3 124 5 384 384 CD cord-023865-6rafp3x3 124 6 ) ) -RRB- cord-023865-6rafp3x3 124 7 . . . cord-023865-6rafp3x3 125 1 These these DT cord-023865-6rafp3x3 125 2 results result NNS cord-023865-6rafp3x3 125 3 are be VBP cord-023865-6rafp3x3 125 4 in in IN cord-023865-6rafp3x3 125 5 agreement agreement NN cord-023865-6rafp3x3 125 6 with with IN cord-023865-6rafp3x3 125 7 previous previous JJ cord-023865-6rafp3x3 125 8 findings finding NNS cord-023865-6rafp3x3 125 9 and and CC cord-023865-6rafp3x3 125 10 further further RB cord-023865-6rafp3x3 125 11 suggest suggest VBP cord-023865-6rafp3x3 125 12 that that IN cord-023865-6rafp3x3 125 13 these these DT cord-023865-6rafp3x3 125 14 two two CD cord-023865-6rafp3x3 125 15 regions region NNS cord-023865-6rafp3x3 125 16 may may MD cord-023865-6rafp3x3 125 17 be be VB cord-023865-6rafp3x3 125 18 functional functional JJ cord-023865-6rafp3x3 125 19 in in IN cord-023865-6rafp3x3 125 20 vivo vivo NN cord-023865-6rafp3x3 125 21 . . . cord-023865-6rafp3x3 126 1 Future future JJ cord-023865-6rafp3x3 126 2 experiments experiment NNS cord-023865-6rafp3x3 126 3 using use VBG cord-023865-6rafp3x3 126 4 a a DT cord-023865-6rafp3x3 126 5 model model NN cord-023865-6rafp3x3 126 6 infection infection NN cord-023865-6rafp3x3 126 7 system system NN cord-023865-6rafp3x3 126 8 will will MD cord-023865-6rafp3x3 126 9 confirm confirm VB cord-023865-6rafp3x3 126 10 these these DT cord-023865-6rafp3x3 126 11 observations observation NNS cord-023865-6rafp3x3 126 12 . . . cord-023865-6rafp3x3 127 1 One one CD cord-023865-6rafp3x3 127 2 of of IN cord-023865-6rafp3x3 127 3 the the DT cord-023865-6rafp3x3 127 4 most most RBS cord-023865-6rafp3x3 127 5 crucial crucial JJ cord-023865-6rafp3x3 127 6 properties property NNS cord-023865-6rafp3x3 127 7 required require VBN cord-023865-6rafp3x3 127 8 by by IN cord-023865-6rafp3x3 127 9 the the DT cord-023865-6rafp3x3 127 10 N n NN cord-023865-6rafp3x3 127 11 - - HYPH cord-023865-6rafp3x3 127 12 protein protein NN cord-023865-6rafp3x3 127 13 for for IN cord-023865-6rafp3x3 127 14 genome genome NN cord-023865-6rafp3x3 127 15 encapsidation encapsidation NN cord-023865-6rafp3x3 127 16 is be VBZ cord-023865-6rafp3x3 127 17 its -PRON- PRP$ cord-023865-6rafp3x3 127 18 ability ability NN cord-023865-6rafp3x3 127 19 to to IN cord-023865-6rafp3x3 127 20 self self NN cord-023865-6rafp3x3 127 21 - - HYPH cord-023865-6rafp3x3 127 22 associate associate NN cord-023865-6rafp3x3 127 23 . . . cord-023865-6rafp3x3 128 1 Therefore therefore RB cord-023865-6rafp3x3 128 2 , , , cord-023865-6rafp3x3 128 3 many many JJ cord-023865-6rafp3x3 128 4 laboratories laboratory NNS cord-023865-6rafp3x3 128 5 have have VBP cord-023865-6rafp3x3 128 6 focused focus VBN cord-023865-6rafp3x3 128 7 on on IN cord-023865-6rafp3x3 128 8 characterizing characterize VBG cord-023865-6rafp3x3 128 9 this this DT cord-023865-6rafp3x3 128 10 phenomenon phenomenon NN cord-023865-6rafp3x3 128 11 , , , cord-023865-6rafp3x3 128 12 with with IN cord-023865-6rafp3x3 128 13 an an DT cord-023865-6rafp3x3 128 14 eye eye NN cord-023865-6rafp3x3 128 15 on on IN cord-023865-6rafp3x3 128 16 developing develop VBG cord-023865-6rafp3x3 128 17 possible possible JJ cord-023865-6rafp3x3 128 18 interference interference NN cord-023865-6rafp3x3 128 19 strategies strategy NNS cord-023865-6rafp3x3 128 20 that that WDT cord-023865-6rafp3x3 128 21 may may MD cord-023865-6rafp3x3 128 22 help help VB cord-023865-6rafp3x3 128 23 in in IN cord-023865-6rafp3x3 128 24 limiting limit VBG cord-023865-6rafp3x3 128 25 virus virus NN cord-023865-6rafp3x3 128 26 propagation propagation NN cord-023865-6rafp3x3 128 27 . . . cord-023865-6rafp3x3 129 1 Initial initial JJ cord-023865-6rafp3x3 129 2 studies study NNS cord-023865-6rafp3x3 129 3 done do VBN cord-023865-6rafp3x3 129 4 in in IN cord-023865-6rafp3x3 129 5 our -PRON- PRP$ cord-023865-6rafp3x3 129 6 laboratory laboratory NN cord-023865-6rafp3x3 129 7 using use VBG cord-023865-6rafp3x3 129 8 a a DT cord-023865-6rafp3x3 129 9 yeast yeast NN cord-023865-6rafp3x3 129 10 two two CD cord-023865-6rafp3x3 129 11 - - HYPH cord-023865-6rafp3x3 129 12 hybrid hybrid NN cord-023865-6rafp3x3 129 13 assay assay NN cord-023865-6rafp3x3 129 14 revealed reveal VBD cord-023865-6rafp3x3 129 15 that that IN cord-023865-6rafp3x3 129 16 N n NN cord-023865-6rafp3x3 129 17 - - HYPH cord-023865-6rafp3x3 129 18 protein protein NN cord-023865-6rafp3x3 129 19 is be VBZ cord-023865-6rafp3x3 129 20 able able JJ cord-023865-6rafp3x3 129 21 to to TO cord-023865-6rafp3x3 129 22 self self NN cord-023865-6rafp3x3 129 23 - - HYPH cord-023865-6rafp3x3 129 24 associate associate VB cord-023865-6rafp3x3 129 25 through through IN cord-023865-6rafp3x3 129 26 its -PRON- PRP$ cord-023865-6rafp3x3 129 27 C c NN cord-023865-6rafp3x3 129 28 - - HYPH cord-023865-6rafp3x3 129 29 terminal terminal NN cord-023865-6rafp3x3 129 30 amino amino NN cord-023865-6rafp3x3 129 31 acid acid NN cord-023865-6rafp3x3 129 32 209 209 CD cord-023865-6rafp3x3 129 33 residues residue NNS cord-023865-6rafp3x3 130 1 ( ( -LRB- cord-023865-6rafp3x3 130 2 Surjit Surjit NNP cord-023865-6rafp3x3 130 3 et et NNP cord-023865-6rafp3x3 130 4 al al NNP cord-023865-6rafp3x3 130 5 . . NNP cord-023865-6rafp3x3 130 6 2004a 2004a CD cord-023865-6rafp3x3 130 7 ) ) -RRB- cord-023865-6rafp3x3 130 8 . . . cord-023865-6rafp3x3 131 1 A a DT cord-023865-6rafp3x3 131 2 parallel parallel JJ cord-023865-6rafp3x3 131 3 study study NN cord-023865-6rafp3x3 131 4 done do VBN cord-023865-6rafp3x3 131 5 by by IN cord-023865-6rafp3x3 131 6 He -PRON- PRP cord-023865-6rafp3x3 131 7 et et FW cord-023865-6rafp3x3 131 8 al al NNP cord-023865-6rafp3x3 131 9 . . . cord-023865-6rafp3x3 132 1 ( ( -LRB- cord-023865-6rafp3x3 132 2 2004 2004 CD cord-023865-6rafp3x3 132 3 ) ) -RRB- cord-023865-6rafp3x3 132 4 using use VBG cord-023865-6rafp3x3 132 5 the the DT cord-023865-6rafp3x3 132 6 mammalian mammalian JJ cord-023865-6rafp3x3 132 7 two two CD cord-023865-6rafp3x3 132 8 - - HYPH cord-023865-6rafp3x3 132 9 hybrid hybrid NN cord-023865-6rafp3x3 132 10 system system NN cord-023865-6rafp3x3 132 11 and and CC cord-023865-6rafp3x3 132 12 sucrose sucrose NN cord-023865-6rafp3x3 132 13 gradient gradient NN cord-023865-6rafp3x3 132 14 fractionation fractionation NN cord-023865-6rafp3x3 132 15 also also RB cord-023865-6rafp3x3 132 16 proved prove VBD cord-023865-6rafp3x3 132 17 the the DT cord-023865-6rafp3x3 132 18 ability ability NN cord-023865-6rafp3x3 132 19 of of IN cord-023865-6rafp3x3 132 20 the the DT cord-023865-6rafp3x3 132 21 N n NN cord-023865-6rafp3x3 132 22 - - HYPH cord-023865-6rafp3x3 132 23 protein protein NN cord-023865-6rafp3x3 132 24 to to IN cord-023865-6rafp3x3 132 25 self self NN cord-023865-6rafp3x3 132 26 - - HYPH cord-023865-6rafp3x3 132 27 associate associate NN cord-023865-6rafp3x3 132 28 to to TO cord-023865-6rafp3x3 132 29 form form VB cord-023865-6rafp3x3 132 30 an an DT cord-023865-6rafp3x3 132 31 oligomer oligomer NN cord-023865-6rafp3x3 132 32 . . . cord-023865-6rafp3x3 133 1 They -PRON- PRP cord-023865-6rafp3x3 133 2 further further RB cord-023865-6rafp3x3 133 3 mapped map VBD cord-023865-6rafp3x3 133 4 the the DT cord-023865-6rafp3x3 133 5 interaction interaction NN cord-023865-6rafp3x3 133 6 region region NN cord-023865-6rafp3x3 133 7 to to IN cord-023865-6rafp3x3 133 8 amino amino NN cord-023865-6rafp3x3 133 9 acid acid NN cord-023865-6rafp3x3 133 10 184 184 CD cord-023865-6rafp3x3 133 11 - - SYM cord-023865-6rafp3x3 133 12 196 196 CD cord-023865-6rafp3x3 133 13 residues residue NNS cord-023865-6rafp3x3 133 14 , , , cord-023865-6rafp3x3 133 15 encompassing encompass VBG cord-023865-6rafp3x3 133 16 the the DT cord-023865-6rafp3x3 133 17 SR SR NNP cord-023865-6rafp3x3 133 18 - - HYPH cord-023865-6rafp3x3 133 19 rich rich JJ cord-023865-6rafp3x3 133 20 motif motif NN cord-023865-6rafp3x3 133 21 . . . cord-023865-6rafp3x3 134 1 However however RB cord-023865-6rafp3x3 134 2 , , , cord-023865-6rafp3x3 134 3 there there EX cord-023865-6rafp3x3 134 4 were be VBD cord-023865-6rafp3x3 134 5 some some DT cord-023865-6rafp3x3 134 6 discrepancies discrepancy NNS cord-023865-6rafp3x3 134 7 regarding regard VBG cord-023865-6rafp3x3 134 8 the the DT cord-023865-6rafp3x3 134 9 interaction interaction NN cord-023865-6rafp3x3 134 10 domain domain NN cord-023865-6rafp3x3 134 11 mapped map VBN cord-023865-6rafp3x3 134 12 in in IN cord-023865-6rafp3x3 134 13 these these DT cord-023865-6rafp3x3 134 14 two two CD cord-023865-6rafp3x3 134 15 studies study NNS cord-023865-6rafp3x3 134 16 . . . cord-023865-6rafp3x3 135 1 Later later RB cord-023865-6rafp3x3 135 2 on on RB cord-023865-6rafp3x3 135 3 , , , cord-023865-6rafp3x3 135 4 extensive extensive JJ cord-023865-6rafp3x3 135 5 biophysical biophysical JJ cord-023865-6rafp3x3 135 6 and and CC cord-023865-6rafp3x3 135 7 biochemical biochemical JJ cord-023865-6rafp3x3 135 8 analysis analysis NN cord-023865-6rafp3x3 135 9 done do VBN cord-023865-6rafp3x3 135 10 by by IN cord-023865-6rafp3x3 135 11 Chen Chen NNP cord-023865-6rafp3x3 135 12 's 's POS cord-023865-6rafp3x3 135 13 laboratory laboratory NN cord-023865-6rafp3x3 135 14 and and CC cord-023865-6rafp3x3 135 15 Jiang Jiang NNP cord-023865-6rafp3x3 135 16 's 's POS cord-023865-6rafp3x3 135 17 laboratory laboratory NN cord-023865-6rafp3x3 135 18 ( ( -LRB- cord-023865-6rafp3x3 135 19 Luo Luo NNP cord-023865-6rafp3x3 135 20 et et NNP cord-023865-6rafp3x3 135 21 al al NNP cord-023865-6rafp3x3 135 22 . . . cord-023865-6rafp3x3 136 1 2006 2006 CD cord-023865-6rafp3x3 137 1 ( ( -LRB- cord-023865-6rafp3x3 137 2 Luo Luo NNP cord-023865-6rafp3x3 137 3 et et NNP cord-023865-6rafp3x3 137 4 al al NNP cord-023865-6rafp3x3 137 5 . . . cord-023865-6rafp3x3 138 1 , , , cord-023865-6rafp3x3 138 2 2005 2005 CD cord-023865-6rafp3x3 138 3 have have VBP cord-023865-6rafp3x3 138 4 enriched enrich VBN cord-023865-6rafp3x3 138 5 our -PRON- PRP$ cord-023865-6rafp3x3 138 6 understanding understanding NN cord-023865-6rafp3x3 138 7 of of IN cord-023865-6rafp3x3 138 8 the the DT cord-023865-6rafp3x3 138 9 oligomerization oligomerization NN cord-023865-6rafp3x3 138 10 process process NN cord-023865-6rafp3x3 138 11 of of IN cord-023865-6rafp3x3 138 12 the the DT cord-023865-6rafp3x3 138 13 Nprotein Nprotein NNP cord-023865-6rafp3x3 138 14 . . . cord-023865-6rafp3x3 139 1 In in IN cord-023865-6rafp3x3 139 2 summary summary NN cord-023865-6rafp3x3 139 3 , , , cord-023865-6rafp3x3 139 4 the the DT cord-023865-6rafp3x3 139 5 SR SR NNP cord-023865-6rafp3x3 139 6 - - HYPH cord-023865-6rafp3x3 139 7 rich rich JJ cord-023865-6rafp3x3 139 8 motif motif NN cord-023865-6rafp3x3 139 9 does do VBZ cord-023865-6rafp3x3 139 10 possess possess VB cord-023865-6rafp3x3 139 11 binding bind VBG cord-023865-6rafp3x3 139 12 affinity affinity NN cord-023865-6rafp3x3 139 13 , , , cord-023865-6rafp3x3 139 14 but but CC cord-023865-6rafp3x3 139 15 this this DT cord-023865-6rafp3x3 139 16 is be VBZ cord-023865-6rafp3x3 139 17 specific specific JJ cord-023865-6rafp3x3 139 18 for for IN cord-023865-6rafp3x3 139 19 the the DT cord-023865-6rafp3x3 139 20 central central JJ cord-023865-6rafp3x3 139 21 region region NN cord-023865-6rafp3x3 139 22 ( ( -LRB- cord-023865-6rafp3x3 139 23 aa aa NNP cord-023865-6rafp3x3 139 24 211 211 CD cord-023865-6rafp3x3 139 25 - - HYPH cord-023865-6rafp3x3 139 26 290 290 CD cord-023865-6rafp3x3 139 27 ) ) -RRB- cord-023865-6rafp3x3 139 28 of of IN cord-023865-6rafp3x3 139 29 another another DT cord-023865-6rafp3x3 139 30 molecule molecule NN cord-023865-6rafp3x3 139 31 of of IN cord-023865-6rafp3x3 139 32 N n NN cord-023865-6rafp3x3 139 33 - - HYPH cord-023865-6rafp3x3 139 34 protein protein NN cord-023865-6rafp3x3 139 35 , , , cord-023865-6rafp3x3 139 36 instead instead RB cord-023865-6rafp3x3 139 37 of of IN cord-023865-6rafp3x3 139 38 the the DT cord-023865-6rafp3x3 139 39 SR SR NNP cord-023865-6rafp3x3 139 40 - - HYPH cord-023865-6rafp3x3 139 41 rich rich JJ cord-023865-6rafp3x3 139 42 motif motif NN cord-023865-6rafp3x3 139 43 itself -PRON- PRP cord-023865-6rafp3x3 139 44 . . . cord-023865-6rafp3x3 140 1 The the DT cord-023865-6rafp3x3 140 2 C c NN cord-023865-6rafp3x3 140 3 - - HYPH cord-023865-6rafp3x3 140 4 terminal terminal NN cord-023865-6rafp3x3 140 5 region region NN cord-023865-6rafp3x3 140 6 ( ( -LRB- cord-023865-6rafp3x3 140 7 aa aa NNP cord-023865-6rafp3x3 140 8 283 283 CD cord-023865-6rafp3x3 140 9 - - HYPH cord-023865-6rafp3x3 140 10 422 422 CD cord-023865-6rafp3x3 140 11 ) ) -RRB- cord-023865-6rafp3x3 140 12 possesses possess VBZ cord-023865-6rafp3x3 140 13 binding bind VBG cord-023865-6rafp3x3 140 14 affinity affinity NN cord-023865-6rafp3x3 140 15 for for IN cord-023865-6rafp3x3 140 16 itself -PRON- PRP cord-023865-6rafp3x3 140 17 and and CC cord-023865-6rafp3x3 140 18 to to TO cord-023865-6rafp3x3 140 19 associate associate VB cord-023865-6rafp3x3 140 20 into into IN cord-023865-6rafp3x3 140 21 a a DT cord-023865-6rafp3x3 140 22 dimer dimer NN cord-023865-6rafp3x3 140 23 , , , cord-023865-6rafp3x3 140 24 trimer trimer NN cord-023865-6rafp3x3 140 25 , , , cord-023865-6rafp3x3 140 26 tetramer tetramer NN cord-023865-6rafp3x3 140 27 or or CC cord-023865-6rafp3x3 140 28 hexamer hexamer NN cord-023865-6rafp3x3 140 29 , , , cord-023865-6rafp3x3 140 30 in in IN cord-023865-6rafp3x3 140 31 a a DT cord-023865-6rafp3x3 140 32 concentration concentration NN cord-023865-6rafp3x3 140 33 - - HYPH cord-023865-6rafp3x3 140 34 dependent dependent JJ cord-023865-6rafp3x3 140 35 manner manner NN cord-023865-6rafp3x3 140 36 . . . cord-023865-6rafp3x3 141 1 The the DT cord-023865-6rafp3x3 141 2 essential essential JJ cord-023865-6rafp3x3 141 3 sequence sequence NN cord-023865-6rafp3x3 141 4 for for IN cord-023865-6rafp3x3 141 5 oligomerization oligomerization NN cord-023865-6rafp3x3 141 6 of of IN cord-023865-6rafp3x3 141 7 the the DT cord-023865-6rafp3x3 141 8 N N NNP cord-023865-6rafp3x3 141 9 - - HYPH cord-023865-6rafp3x3 141 10 protein protein NN cord-023865-6rafp3x3 141 11 was be VBD cord-023865-6rafp3x3 141 12 identified identify VBN cord-023865-6rafp3x3 141 13 to to TO cord-023865-6rafp3x3 141 14 be be VB cord-023865-6rafp3x3 141 15 residues residue NNS cord-023865-6rafp3x3 141 16 343 343 CD cord-023865-6rafp3x3 141 17 - - SYM cord-023865-6rafp3x3 141 18 402 402 CD cord-023865-6rafp3x3 141 19 . . . cord-023865-6rafp3x3 142 1 Interestingly interestingly RB cord-023865-6rafp3x3 142 2 , , , cord-023865-6rafp3x3 142 3 this this DT cord-023865-6rafp3x3 142 4 region region NN cord-023865-6rafp3x3 142 5 also also RB cord-023865-6rafp3x3 142 6 encompasses encompass VBZ cord-023865-6rafp3x3 142 7 the the DT cord-023865-6rafp3x3 142 8 RNA RNA NNP cord-023865-6rafp3x3 142 9 binding binding NN cord-023865-6rafp3x3 142 10 motif motif NN cord-023865-6rafp3x3 142 11 of of IN cord-023865-6rafp3x3 142 12 the the DT cord-023865-6rafp3x3 142 13 N n NN cord-023865-6rafp3x3 142 14 - - HYPH cord-023865-6rafp3x3 142 15 protein protein NN cord-023865-6rafp3x3 142 16 , , , cord-023865-6rafp3x3 142 17 which which WDT cord-023865-6rafp3x3 142 18 prompts prompt VBZ cord-023865-6rafp3x3 142 19 us -PRON- PRP cord-023865-6rafp3x3 142 20 to to TO cord-023865-6rafp3x3 142 21 speculate speculate VB cord-023865-6rafp3x3 142 22 that that IN cord-023865-6rafp3x3 142 23 there there EX cord-023865-6rafp3x3 142 24 might may MD cord-023865-6rafp3x3 142 25 be be VB cord-023865-6rafp3x3 142 26 mutual mutual JJ cord-023865-6rafp3x3 142 27 interplay interplay NN cord-023865-6rafp3x3 142 28 between between IN cord-023865-6rafp3x3 142 29 RNA rna NN cord-023865-6rafp3x3 142 30 binding binding NN cord-023865-6rafp3x3 142 31 and and CC cord-023865-6rafp3x3 142 32 oligomerization oligomerization NN cord-023865-6rafp3x3 142 33 activities activity NNS cord-023865-6rafp3x3 142 34 of of IN cord-023865-6rafp3x3 142 35 the the DT cord-023865-6rafp3x3 142 36 N n NN cord-023865-6rafp3x3 142 37 - - HYPH cord-023865-6rafp3x3 142 38 protein protein NN cord-023865-6rafp3x3 142 39 . . . cord-023865-6rafp3x3 143 1 Further further RB cord-023865-6rafp3x3 143 2 , , , cord-023865-6rafp3x3 143 3 the the DT cord-023865-6rafp3x3 143 4 oligomerization oligomerization NN cord-023865-6rafp3x3 143 5 was be VBD cord-023865-6rafp3x3 143 6 observed observe VBN cord-023865-6rafp3x3 143 7 to to TO cord-023865-6rafp3x3 143 8 be be VB cord-023865-6rafp3x3 143 9 independent independent JJ cord-023865-6rafp3x3 143 10 of of IN cord-023865-6rafp3x3 143 11 electrostatic electrostatic JJ cord-023865-6rafp3x3 143 12 interactions interaction NNS cord-023865-6rafp3x3 143 13 and and CC cord-023865-6rafp3x3 143 14 addition addition NN cord-023865-6rafp3x3 143 15 of of IN cord-023865-6rafp3x3 143 16 single single JJ cord-023865-6rafp3x3 143 17 strand strand NN cord-023865-6rafp3x3 143 18 DNA dna NN cord-023865-6rafp3x3 143 19 to to IN cord-023865-6rafp3x3 143 20 the the DT cord-023865-6rafp3x3 143 21 reaction reaction NN cord-023865-6rafp3x3 143 22 mixture mixture NN cord-023865-6rafp3x3 143 23 containing contain VBG cord-023865-6rafp3x3 143 24 tetramers tetramer NNS cord-023865-6rafp3x3 143 25 of of IN cord-023865-6rafp3x3 143 26 the the DT cord-023865-6rafp3x3 143 27 N N NNP cord-023865-6rafp3x3 143 28 - - HYPH cord-023865-6rafp3x3 143 29 protein protein NN cord-023865-6rafp3x3 143 30 promoted promote VBD cord-023865-6rafp3x3 143 31 oligomerization oligomerization NN cord-023865-6rafp3x3 143 32 . . . cord-023865-6rafp3x3 144 1 Thus thus RB cord-023865-6rafp3x3 144 2 , , , cord-023865-6rafp3x3 144 3 it -PRON- PRP cord-023865-6rafp3x3 144 4 has have VBZ cord-023865-6rafp3x3 144 5 been be VBN cord-023865-6rafp3x3 144 6 proposed propose VBN cord-023865-6rafp3x3 144 7 that that IN cord-023865-6rafp3x3 144 8 once once IN cord-023865-6rafp3x3 144 9 the the DT cord-023865-6rafp3x3 144 10 tetramer tetramer NN cord-023865-6rafp3x3 144 11 is be VBZ cord-023865-6rafp3x3 144 12 formed form VBN cord-023865-6rafp3x3 144 13 by by IN cord-023865-6rafp3x3 144 14 protein protein NN cord-023865-6rafp3x3 144 15 - - HYPH cord-023865-6rafp3x3 144 16 protein protein NN cord-023865-6rafp3x3 144 17 interaction interaction NN cord-023865-6rafp3x3 144 18 between between IN cord-023865-6rafp3x3 144 19 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 144 20 molecules molecule NNS cord-023865-6rafp3x3 144 21 , , , cord-023865-6rafp3x3 144 22 binding bind VBG cord-023865-6rafp3x3 144 23 with with IN cord-023865-6rafp3x3 144 24 genomic genomic JJ cord-023865-6rafp3x3 144 25 RNA RNA NNP cord-023865-6rafp3x3 144 26 prompts prompt NNS cord-023865-6rafp3x3 144 27 further further JJ cord-023865-6rafp3x3 144 28 assembly assembly NN cord-023865-6rafp3x3 144 29 of of IN cord-023865-6rafp3x3 144 30 the the DT cord-023865-6rafp3x3 144 31 complete complete JJ cord-023865-6rafp3x3 144 32 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 144 33 structure structure NN cord-023865-6rafp3x3 144 34 . . . cord-023865-6rafp3x3 145 1 Besides besides IN cord-023865-6rafp3x3 145 2 being be VBG cord-023865-6rafp3x3 145 3 the the DT cord-023865-6rafp3x3 145 4 capsid capsid JJ cord-023865-6rafp3x3 145 5 protein protein NN cord-023865-6rafp3x3 145 6 of of IN cord-023865-6rafp3x3 145 7 the the DT cord-023865-6rafp3x3 145 8 virus virus NN cord-023865-6rafp3x3 145 9 , , , cord-023865-6rafp3x3 145 10 the the DT cord-023865-6rafp3x3 145 11 N n NN cord-023865-6rafp3x3 145 12 - - HYPH cord-023865-6rafp3x3 145 13 protein protein NN cord-023865-6rafp3x3 145 14 of of IN cord-023865-6rafp3x3 145 15 many many JJ cord-023865-6rafp3x3 145 16 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 145 17 is be VBZ cord-023865-6rafp3x3 145 18 known know VBN cord-023865-6rafp3x3 145 19 to to TO cord-023865-6rafp3x3 145 20 double double VB cord-023865-6rafp3x3 145 21 up up RP cord-023865-6rafp3x3 145 22 as as IN cord-023865-6rafp3x3 145 23 a a DT cord-023865-6rafp3x3 145 24 regulatory regulatory JJ cord-023865-6rafp3x3 145 25 protein protein NN cord-023865-6rafp3x3 145 26 . . . cord-023865-6rafp3x3 146 1 The the DT cord-023865-6rafp3x3 146 2 N n NN cord-023865-6rafp3x3 146 3 - - HYPH cord-023865-6rafp3x3 146 4 protein protein NN cord-023865-6rafp3x3 146 5 of of IN cord-023865-6rafp3x3 146 6 the the DT cord-023865-6rafp3x3 146 7 SARS SARS NNP cord-023865-6rafp3x3 146 8 - - HYPH cord-023865-6rafp3x3 146 9 CoV CoV NNP cord-023865-6rafp3x3 146 10 too too RB cord-023865-6rafp3x3 146 11 has have VBZ cord-023865-6rafp3x3 146 12 been be VBN cord-023865-6rafp3x3 146 13 shown show VBN cord-023865-6rafp3x3 146 14 to to TO cord-023865-6rafp3x3 146 15 modulate modulate VB cord-023865-6rafp3x3 146 16 the the DT cord-023865-6rafp3x3 146 17 host host NN cord-023865-6rafp3x3 146 18 cellular cellular JJ cord-023865-6rafp3x3 146 19 machinery machinery NN cord-023865-6rafp3x3 146 20 in in IN cord-023865-6rafp3x3 146 21 vitro vitro FW cord-023865-6rafp3x3 146 22 , , , cord-023865-6rafp3x3 146 23 thereby thereby RB cord-023865-6rafp3x3 146 24 indicating indicate VBG cord-023865-6rafp3x3 146 25 its -PRON- PRP$ cord-023865-6rafp3x3 146 26 possible possible JJ cord-023865-6rafp3x3 146 27 regulatory regulatory JJ cord-023865-6rafp3x3 146 28 role role NN cord-023865-6rafp3x3 146 29 during during IN cord-023865-6rafp3x3 146 30 its -PRON- PRP$ cord-023865-6rafp3x3 146 31 viral viral JJ cord-023865-6rafp3x3 146 32 life life NN cord-023865-6rafp3x3 146 33 - - HYPH cord-023865-6rafp3x3 146 34 cycle cycle NN cord-023865-6rafp3x3 146 35 . . . cord-023865-6rafp3x3 147 1 Some some DT cord-023865-6rafp3x3 147 2 of of IN cord-023865-6rafp3x3 147 3 the the DT cord-023865-6rafp3x3 147 4 major major JJ cord-023865-6rafp3x3 147 5 cellular cellular JJ cord-023865-6rafp3x3 147 6 processes process NNS cord-023865-6rafp3x3 147 7 perturbed perturb VBN cord-023865-6rafp3x3 147 8 by by IN cord-023865-6rafp3x3 147 9 heterologous heterologous JJ cord-023865-6rafp3x3 147 10 expression expression NN cord-023865-6rafp3x3 147 11 of of IN cord-023865-6rafp3x3 147 12 the the DT cord-023865-6rafp3x3 147 13 N N NNP cord-023865-6rafp3x3 147 14 - - HYPH cord-023865-6rafp3x3 147 15 protein protein NN cord-023865-6rafp3x3 147 16 are be VBP cord-023865-6rafp3x3 147 17 discussed discuss VBN cord-023865-6rafp3x3 147 18 below below RB cord-023865-6rafp3x3 147 19 . . . cord-023865-6rafp3x3 148 1 Three three CD cord-023865-6rafp3x3 148 2 different different JJ cord-023865-6rafp3x3 148 3 groups group NNS cord-023865-6rafp3x3 148 4 have have VBP cord-023865-6rafp3x3 148 5 reported report VBN cord-023865-6rafp3x3 148 6 the the DT cord-023865-6rafp3x3 148 7 ability ability NN cord-023865-6rafp3x3 148 8 of of IN cord-023865-6rafp3x3 148 9 the the DT cord-023865-6rafp3x3 148 10 N n NN cord-023865-6rafp3x3 148 11 - - HYPH cord-023865-6rafp3x3 148 12 protein protein NN cord-023865-6rafp3x3 148 13 to to TO cord-023865-6rafp3x3 148 14 interfere interfere VB cord-023865-6rafp3x3 148 15 with with IN cord-023865-6rafp3x3 148 16 the the DT cord-023865-6rafp3x3 148 17 host host NN cord-023865-6rafp3x3 148 18 cell cell NN cord-023865-6rafp3x3 148 19 cycle cycle NN cord-023865-6rafp3x3 148 20 in in IN cord-023865-6rafp3x3 148 21 vitro vitro FW cord-023865-6rafp3x3 148 22 . . . cord-023865-6rafp3x3 149 1 Work work NN cord-023865-6rafp3x3 149 2 done do VBN cord-023865-6rafp3x3 149 3 by by IN cord-023865-6rafp3x3 149 4 Li Li NNP cord-023865-6rafp3x3 149 5 et et NNP cord-023865-6rafp3x3 149 6 al al NNP cord-023865-6rafp3x3 149 7 . . . cord-023865-6rafp3x3 150 1 ( ( -LRB- cord-023865-6rafp3x3 150 2 2005a 2005a CD cord-023865-6rafp3x3 150 3 Li Li NNP cord-023865-6rafp3x3 150 4 et et NNP cord-023865-6rafp3x3 150 5 al al NNP cord-023865-6rafp3x3 150 6 . . . cord-023865-6rafp3x3 151 1 ( ( -LRB- cord-023865-6rafp3x3 151 2 , , , cord-023865-6rafp3x3 151 3 2005b 2005b CD cord-023865-6rafp3x3 151 4 proved prove VBD cord-023865-6rafp3x3 151 5 that that IN cord-023865-6rafp3x3 151 6 mutation mutation NN cord-023865-6rafp3x3 151 7 of of IN cord-023865-6rafp3x3 151 8 the the DT cord-023865-6rafp3x3 151 9 sumoylation sumoylation NN cord-023865-6rafp3x3 151 10 motif motif NN cord-023865-6rafp3x3 151 11 in in IN cord-023865-6rafp3x3 151 12 the the DT cord-023865-6rafp3x3 151 13 N n CD cord-023865-6rafp3x3 151 14 - - HYPH cord-023865-6rafp3x3 151 15 protein protein NN cord-023865-6rafp3x3 151 16 leads lead VBZ cord-023865-6rafp3x3 151 17 to to IN cord-023865-6rafp3x3 151 18 cell cell NN cord-023865-6rafp3x3 151 19 cycle cycle NN cord-023865-6rafp3x3 151 20 arrest arrest NN cord-023865-6rafp3x3 151 21 . . . cord-023865-6rafp3x3 152 1 Work work NN cord-023865-6rafp3x3 152 2 done do VBN cord-023865-6rafp3x3 152 3 in in IN cord-023865-6rafp3x3 152 4 our -PRON- PRP$ cord-023865-6rafp3x3 152 5 laboratory laboratory NN cord-023865-6rafp3x3 152 6 has have VBZ cord-023865-6rafp3x3 152 7 shown show VBN cord-023865-6rafp3x3 152 8 the the DT cord-023865-6rafp3x3 152 9 inhibition inhibition NN cord-023865-6rafp3x3 152 10 of of IN cord-023865-6rafp3x3 152 11 S s NN cord-023865-6rafp3x3 152 12 phase phase NN cord-023865-6rafp3x3 152 13 progression progression NN cord-023865-6rafp3x3 152 14 in in IN cord-023865-6rafp3x3 152 15 cells cell NNS cord-023865-6rafp3x3 152 16 expressing express VBG cord-023865-6rafp3x3 152 17 the the DT cord-023865-6rafp3x3 152 18 N n CD cord-023865-6rafp3x3 152 19 - - HYPH cord-023865-6rafp3x3 152 20 protein protein NN cord-023865-6rafp3x3 152 21 ( ( -LRB- cord-023865-6rafp3x3 152 22 Surjit Surjit NNP cord-023865-6rafp3x3 152 23 et et NNP cord-023865-6rafp3x3 152 24 al al NNP cord-023865-6rafp3x3 152 25 . . . cord-023865-6rafp3x3 152 26 2006 2006 CD cord-023865-6rafp3x3 152 27 ) ) -RRB- cord-023865-6rafp3x3 152 28 . . . cord-023865-6rafp3x3 153 1 Further further RB cord-023865-6rafp3x3 153 2 , , , cord-023865-6rafp3x3 153 3 S s NN cord-023865-6rafp3x3 153 4 - - HYPH cord-023865-6rafp3x3 153 5 phase phase VB cord-023865-6rafp3x3 153 6 specific specific JJ cord-023865-6rafp3x3 153 7 gene gene NN cord-023865-6rafp3x3 153 8 products product NNS cord-023865-6rafp3x3 153 9 like like IN cord-023865-6rafp3x3 153 10 cyclin cyclin NN cord-023865-6rafp3x3 153 11 E E NNP cord-023865-6rafp3x3 153 12 and and CC cord-023865-6rafp3x3 153 13 CDK2 CDK2 NNP cord-023865-6rafp3x3 153 14 were be VBD cord-023865-6rafp3x3 153 15 found find VBN cord-023865-6rafp3x3 153 16 to to TO cord-023865-6rafp3x3 153 17 be be VB cord-023865-6rafp3x3 153 18 downregulated downregulate VBN cord-023865-6rafp3x3 153 19 in in IN cord-023865-6rafp3x3 153 20 SARS SARS NNP cord-023865-6rafp3x3 153 21 - - HYPH cord-023865-6rafp3x3 153 22 CoV CoV NNP cord-023865-6rafp3x3 153 23 infected infected JJ cord-023865-6rafp3x3 153 24 cell cell NN cord-023865-6rafp3x3 153 25 lysate lysate NN cord-023865-6rafp3x3 153 26 , , , cord-023865-6rafp3x3 153 27 which which WDT cord-023865-6rafp3x3 153 28 suggested suggest VBD cord-023865-6rafp3x3 153 29 that that IN cord-023865-6rafp3x3 153 30 the the DT cord-023865-6rafp3x3 153 31 observed observed JJ cord-023865-6rafp3x3 153 32 phenomenon phenomenon NN cord-023865-6rafp3x3 153 33 may may MD cord-023865-6rafp3x3 153 34 be be VB cord-023865-6rafp3x3 153 35 relevant relevant JJ cord-023865-6rafp3x3 153 36 in in IN cord-023865-6rafp3x3 153 37 vivo vivo NN cord-023865-6rafp3x3 153 38 . . . cord-023865-6rafp3x3 154 1 In in IN cord-023865-6rafp3x3 154 2 an an DT cord-023865-6rafp3x3 154 3 attempt attempt NN cord-023865-6rafp3x3 154 4 to to TO cord-023865-6rafp3x3 154 5 further further RB cord-023865-6rafp3x3 154 6 characterize characterize VB cord-023865-6rafp3x3 154 7 the the DT cord-023865-6rafp3x3 154 8 mechanism mechanism NN cord-023865-6rafp3x3 154 9 of of IN cord-023865-6rafp3x3 154 10 cell cell NN cord-023865-6rafp3x3 154 11 cycle cycle NN cord-023865-6rafp3x3 154 12 blockage blockage NN cord-023865-6rafp3x3 154 13 induced induce VBN cord-023865-6rafp3x3 154 14 by by IN cord-023865-6rafp3x3 154 15 the the DT cord-023865-6rafp3x3 154 16 N N NNP cord-023865-6rafp3x3 154 17 - - HYPH cord-023865-6rafp3x3 154 18 protein protein NN cord-023865-6rafp3x3 154 19 , , , cord-023865-6rafp3x3 154 20 several several JJ cord-023865-6rafp3x3 154 21 biochemical biochemical JJ cord-023865-6rafp3x3 154 22 and and CC cord-023865-6rafp3x3 154 23 mutational mutational JJ cord-023865-6rafp3x3 154 24 analysis analysis NN cord-023865-6rafp3x3 154 25 were be VBD cord-023865-6rafp3x3 154 26 carried carry VBN cord-023865-6rafp3x3 154 27 out out RP cord-023865-6rafp3x3 154 28 . . . cord-023865-6rafp3x3 155 1 Results result NNS cord-023865-6rafp3x3 155 2 thus thus RB cord-023865-6rafp3x3 155 3 obtained obtain VBD cord-023865-6rafp3x3 155 4 demonstrated demonstrate VBD cord-023865-6rafp3x3 155 5 that that IN cord-023865-6rafp3x3 155 6 the the DT cord-023865-6rafp3x3 155 7 N n NN cord-023865-6rafp3x3 155 8 - - HYPH cord-023865-6rafp3x3 155 9 protein protein NN cord-023865-6rafp3x3 155 10 directly directly RB cord-023865-6rafp3x3 155 11 inhibits inhibit VBZ cord-023865-6rafp3x3 155 12 the the DT cord-023865-6rafp3x3 155 13 activity activity NN cord-023865-6rafp3x3 155 14 of of IN cord-023865-6rafp3x3 155 15 the the DT cord-023865-6rafp3x3 155 16 cyclin cyclin NN cord-023865-6rafp3x3 155 17 - - HYPH cord-023865-6rafp3x3 155 18 CDK CDK NNP cord-023865-6rafp3x3 155 19 complex complex NN cord-023865-6rafp3x3 155 20 , , , cord-023865-6rafp3x3 155 21 resulting result VBG cord-023865-6rafp3x3 155 22 in in IN cord-023865-6rafp3x3 155 23 hypophosphorylation hypophosphorylation NN cord-023865-6rafp3x3 155 24 of of IN cord-023865-6rafp3x3 155 25 retinoblastoma retinoblastoma NN cord-023865-6rafp3x3 155 26 protein protein NN cord-023865-6rafp3x3 155 27 with with IN cord-023865-6rafp3x3 155 28 a a DT cord-023865-6rafp3x3 155 29 concomitant concomitant JJ cord-023865-6rafp3x3 155 30 downregulation downregulation NN cord-023865-6rafp3x3 155 31 of of IN cord-023865-6rafp3x3 155 32 E2F1-mediated e2f1-mediate VBN cord-023865-6rafp3x3 155 33 transactivation transactivation NN cord-023865-6rafp3x3 155 34 . . . cord-023865-6rafp3x3 156 1 Analysis Analysis NNP cord-023865-6rafp3x3 156 2 of of IN cord-023865-6rafp3x3 156 3 RXL RXL NNP cord-023865-6rafp3x3 156 4 and and CC cord-023865-6rafp3x3 156 5 CDK CDK NNP cord-023865-6rafp3x3 156 6 phosphorylation phosphorylation NN cord-023865-6rafp3x3 156 7 mutant mutant JJ cord-023865-6rafp3x3 156 8 N n CD cord-023865-6rafp3x3 156 9 - - HYPH cord-023865-6rafp3x3 156 10 protein protein NN cord-023865-6rafp3x3 156 11 identified identify VBD cord-023865-6rafp3x3 156 12 the the DT cord-023865-6rafp3x3 156 13 mechanisms mechanism NNS cord-023865-6rafp3x3 156 14 of of IN cord-023865-6rafp3x3 156 15 inhibition inhibition NN cord-023865-6rafp3x3 156 16 of of IN cord-023865-6rafp3x3 156 17 CDK4 CDK4 NNP cord-023865-6rafp3x3 156 18 and and CC cord-023865-6rafp3x3 156 19 CDK2 CDK2 NNP cord-023865-6rafp3x3 156 20 activity activity NN cord-023865-6rafp3x3 156 21 to to TO cord-023865-6rafp3x3 156 22 be be VB cord-023865-6rafp3x3 156 23 different different JJ cord-023865-6rafp3x3 156 24 . . . cord-023865-6rafp3x3 157 1 Whereas whereas IN cord-023865-6rafp3x3 157 2 the the DT cord-023865-6rafp3x3 157 3 N n NN cord-023865-6rafp3x3 157 4 - - HYPH cord-023865-6rafp3x3 157 5 protein protein NN cord-023865-6rafp3x3 157 6 could could MD cord-023865-6rafp3x3 157 7 directly directly RB cord-023865-6rafp3x3 157 8 bind bind VB cord-023865-6rafp3x3 157 9 to to IN cord-023865-6rafp3x3 157 10 cyclin cyclin NN cord-023865-6rafp3x3 157 11 D d NN cord-023865-6rafp3x3 157 12 and and CC cord-023865-6rafp3x3 157 13 inhibit inhibit VB cord-023865-6rafp3x3 157 14 the the DT cord-023865-6rafp3x3 157 15 activity activity NN cord-023865-6rafp3x3 157 16 of of IN cord-023865-6rafp3x3 157 17 the the DT cord-023865-6rafp3x3 157 18 CDK4-cyclinD cdk4-cyclind CD cord-023865-6rafp3x3 157 19 complex complex JJ cord-023865-6rafp3x3 157 20 , , , cord-023865-6rafp3x3 157 21 inhibition inhibition NN cord-023865-6rafp3x3 157 22 of of IN cord-023865-6rafp3x3 157 23 CDK2 CDK2 NNP cord-023865-6rafp3x3 157 24 activity activity NN cord-023865-6rafp3x3 157 25 appeared appear VBD cord-023865-6rafp3x3 157 26 to to TO cord-023865-6rafp3x3 157 27 be be VB cord-023865-6rafp3x3 157 28 achieved achieve VBN cord-023865-6rafp3x3 157 29 in in IN cord-023865-6rafp3x3 157 30 two two CD cord-023865-6rafp3x3 157 31 different different JJ cord-023865-6rafp3x3 157 32 ways way NNS cord-023865-6rafp3x3 157 33 : : : cord-023865-6rafp3x3 157 34 indirectly indirectly RB cord-023865-6rafp3x3 157 35 by by IN cord-023865-6rafp3x3 157 36 downregulation downregulation NN cord-023865-6rafp3x3 157 37 of of IN cord-023865-6rafp3x3 157 38 protein protein NN cord-023865-6rafp3x3 157 39 levels level NNS cord-023865-6rafp3x3 157 40 of of IN cord-023865-6rafp3x3 157 41 CDK2 CDK2 NNP cord-023865-6rafp3x3 157 42 , , , cord-023865-6rafp3x3 157 43 cyclin cyclin NN cord-023865-6rafp3x3 157 44 E e NN cord-023865-6rafp3x3 157 45 , , , cord-023865-6rafp3x3 157 46 and and CC cord-023865-6rafp3x3 157 47 cyclin cyclin NNP cord-023865-6rafp3x3 157 48 A a NN cord-023865-6rafp3x3 157 49 , , , cord-023865-6rafp3x3 157 50 and and CC cord-023865-6rafp3x3 157 51 by by IN cord-023865-6rafp3x3 157 52 direct direct JJ cord-023865-6rafp3x3 157 53 binding binding NN cord-023865-6rafp3x3 157 54 of of IN cord-023865-6rafp3x3 157 55 N n NN cord-023865-6rafp3x3 157 56 - - HYPH cord-023865-6rafp3x3 157 57 protein protein NN cord-023865-6rafp3x3 157 58 to to IN cord-023865-6rafp3x3 157 59 the the DT cord-023865-6rafp3x3 157 60 CDK2-cyclin CDK2-cyclin NNP cord-023865-6rafp3x3 157 61 complex complex NN cord-023865-6rafp3x3 157 62 . . . cord-023865-6rafp3x3 158 1 A a DT cord-023865-6rafp3x3 158 2 third third JJ cord-023865-6rafp3x3 158 3 piee piee NN cord-023865-6rafp3x3 158 4 of of IN cord-023865-6rafp3x3 158 5 evidence evidence NN cord-023865-6rafp3x3 158 6 supporting support VBG cord-023865-6rafp3x3 158 7 the the DT cord-023865-6rafp3x3 158 8 ability ability NN cord-023865-6rafp3x3 158 9 of of IN cord-023865-6rafp3x3 158 10 N n NN cord-023865-6rafp3x3 158 11 - - HYPH cord-023865-6rafp3x3 158 12 protein protein NN cord-023865-6rafp3x3 158 13 to to TO cord-023865-6rafp3x3 158 14 deregulate deregulate VB cord-023865-6rafp3x3 158 15 the the DT cord-023865-6rafp3x3 158 16 host host NN cord-023865-6rafp3x3 158 17 cycle cycle NN cord-023865-6rafp3x3 158 18 came come VBD cord-023865-6rafp3x3 158 19 from from IN cord-023865-6rafp3x3 158 20 the the DT cord-023865-6rafp3x3 158 21 work work NN cord-023865-6rafp3x3 158 22 of of IN cord-023865-6rafp3x3 158 23 Zhou Zhou NNP cord-023865-6rafp3x3 158 24 et et NNP cord-023865-6rafp3x3 158 25 al al NNP cord-023865-6rafp3x3 158 26 . . . cord-023865-6rafp3x3 159 1 ( ( -LRB- cord-023865-6rafp3x3 159 2 2008 2008 CD cord-023865-6rafp3x3 159 3 ) ) -RRB- cord-023865-6rafp3x3 159 4 . . . cord-023865-6rafp3x3 160 1 They -PRON- PRP cord-023865-6rafp3x3 160 2 observed observe VBD cord-023865-6rafp3x3 160 3 slower slow JJR cord-023865-6rafp3x3 160 4 transition transition NN cord-023865-6rafp3x3 160 5 from from IN cord-023865-6rafp3x3 160 6 S S NNP cord-023865-6rafp3x3 160 7 to to IN cord-023865-6rafp3x3 160 8 G2 G2 NNP cord-023865-6rafp3x3 160 9 / / SYM cord-023865-6rafp3x3 160 10 M M NNP cord-023865-6rafp3x3 160 11 phase phase NN cord-023865-6rafp3x3 160 12 and and CC cord-023865-6rafp3x3 160 13 slower slow JJR cord-023865-6rafp3x3 160 14 growth growth NN cord-023865-6rafp3x3 160 15 rate rate NN cord-023865-6rafp3x3 160 16 in in IN cord-023865-6rafp3x3 160 17 N n CD cord-023865-6rafp3x3 160 18 - - HYPH cord-023865-6rafp3x3 160 19 protein protein NN cord-023865-6rafp3x3 160 20 - - HYPH cord-023865-6rafp3x3 160 21 expressing express VBG cord-023865-6rafp3x3 160 22 293 293 CD cord-023865-6rafp3x3 160 23 T T NNP cord-023865-6rafp3x3 160 24 cells cell NNS cord-023865-6rafp3x3 160 25 . . . cord-023865-6rafp3x3 161 1 They -PRON- PRP cord-023865-6rafp3x3 161 2 also also RB cord-023865-6rafp3x3 161 3 observed observe VBD cord-023865-6rafp3x3 161 4 a a DT cord-023865-6rafp3x3 161 5 similar similar JJ cord-023865-6rafp3x3 161 6 phenomenon phenomenon NN cord-023865-6rafp3x3 161 7 in in IN cord-023865-6rafp3x3 161 8 human human JJ cord-023865-6rafp3x3 161 9 peripheral peripheral JJ cord-023865-6rafp3x3 161 10 blood blood NN cord-023865-6rafp3x3 161 11 lymphocyte lymphocyte NN cord-023865-6rafp3x3 161 12 and and CC cord-023865-6rafp3x3 161 13 K K NNP cord-023865-6rafp3x3 161 14 562 562 CD cord-023865-6rafp3x3 161 15 cells cell NNS cord-023865-6rafp3x3 161 16 infected infect VBN cord-023865-6rafp3x3 161 17 with with IN cord-023865-6rafp3x3 161 18 a a DT cord-023865-6rafp3x3 161 19 retrovirus retrovirus NN cord-023865-6rafp3x3 161 20 expressing express VBG cord-023865-6rafp3x3 161 21 SARS SARS NNP cord-023865-6rafp3x3 161 22 - - HYPH cord-023865-6rafp3x3 161 23 CoV CoV NNP cord-023865-6rafp3x3 161 24 N N NNP cord-023865-6rafp3x3 161 25 - - HYPH cord-023865-6rafp3x3 161 26 protein protein NN cord-023865-6rafp3x3 161 27 . . . cord-023865-6rafp3x3 162 1 While while IN cord-023865-6rafp3x3 162 2 searching search VBG cord-023865-6rafp3x3 162 3 for for IN cord-023865-6rafp3x3 162 4 interaction interaction NN cord-023865-6rafp3x3 162 5 partners partner NNS cord-023865-6rafp3x3 162 6 for for IN cord-023865-6rafp3x3 162 7 the the DT cord-023865-6rafp3x3 162 8 C C NNP cord-023865-6rafp3x3 162 9 terminus terminus NN cord-023865-6rafp3x3 162 10 of of IN cord-023865-6rafp3x3 162 11 N N NNP cord-023865-6rafp3x3 162 12 - - HYPH cord-023865-6rafp3x3 162 13 protein protein NNP cord-023865-6rafp3x3 162 14 ( ( -LRB- cord-023865-6rafp3x3 162 15 aa aa NNP cord-023865-6rafp3x3 162 16 251 251 CD cord-023865-6rafp3x3 162 17 - - HYPH cord-023865-6rafp3x3 162 18 422 422 CD cord-023865-6rafp3x3 162 19 ) ) -RRB- cord-023865-6rafp3x3 162 20 by by IN cord-023865-6rafp3x3 162 21 following follow VBG cord-023865-6rafp3x3 162 22 a a DT cord-023865-6rafp3x3 162 23 yeast yeast NN cord-023865-6rafp3x3 162 24 two two CD cord-023865-6rafp3x3 162 25 - - HYPH cord-023865-6rafp3x3 162 26 hybrid hybrid NN cord-023865-6rafp3x3 162 27 library library NN cord-023865-6rafp3x3 162 28 screening screening NN cord-023865-6rafp3x3 162 29 approach approach NN cord-023865-6rafp3x3 162 30 , , , cord-023865-6rafp3x3 162 31 Zhou Zhou NNP cord-023865-6rafp3x3 162 32 et et NNP cord-023865-6rafp3x3 162 33 al al NNP cord-023865-6rafp3x3 162 34 . . . cord-023865-6rafp3x3 163 1 ( ( -LRB- cord-023865-6rafp3x3 163 2 2008 2008 CD cord-023865-6rafp3x3 163 3 ) ) -RRB- cord-023865-6rafp3x3 163 4 discovered discover VBD cord-023865-6rafp3x3 163 5 human human JJ cord-023865-6rafp3x3 163 6 elongation elongation NN cord-023865-6rafp3x3 163 7 factor factor NN cord-023865-6rafp3x3 163 8 1 1 CD cord-023865-6rafp3x3 163 9 alpha alpha NN cord-023865-6rafp3x3 163 10 ( ( -LRB- cord-023865-6rafp3x3 163 11 EF1a EF1a NNP cord-023865-6rafp3x3 163 12 ) ) -RRB- cord-023865-6rafp3x3 163 13 as as IN cord-023865-6rafp3x3 163 14 a a DT cord-023865-6rafp3x3 163 15 candidate candidate NN cord-023865-6rafp3x3 163 16 partner partner NN cord-023865-6rafp3x3 163 17 . . . cord-023865-6rafp3x3 164 1 The the DT cord-023865-6rafp3x3 164 2 specificity specificity NN cord-023865-6rafp3x3 164 3 of of IN cord-023865-6rafp3x3 164 4 the the DT cord-023865-6rafp3x3 164 5 interaction interaction NN cord-023865-6rafp3x3 164 6 was be VBD cord-023865-6rafp3x3 164 7 confirmed confirm VBN cord-023865-6rafp3x3 164 8 by by IN cord-023865-6rafp3x3 164 9 various various JJ cord-023865-6rafp3x3 164 10 in in IN cord-023865-6rafp3x3 164 11 - - HYPH cord-023865-6rafp3x3 164 12 vitro vitro FW cord-023865-6rafp3x3 164 13 and and CC cord-023865-6rafp3x3 164 14 in in IN cord-023865-6rafp3x3 164 15 - - HYPH cord-023865-6rafp3x3 164 16 vivo vivo NN cord-023865-6rafp3x3 164 17 assays assay NNS cord-023865-6rafp3x3 164 18 . . . cord-023865-6rafp3x3 165 1 Further further RB cord-023865-6rafp3x3 165 2 , , , cord-023865-6rafp3x3 165 3 expression expression NN cord-023865-6rafp3x3 165 4 of of IN cord-023865-6rafp3x3 165 5 N n CD cord-023865-6rafp3x3 165 6 - - HYPH cord-023865-6rafp3x3 165 7 protein protein NN cord-023865-6rafp3x3 165 8 induced induce VBN cord-023865-6rafp3x3 165 9 aggregation aggregation NN cord-023865-6rafp3x3 165 10 of of IN cord-023865-6rafp3x3 165 11 EF1a EF1a NNP cord-023865-6rafp3x3 165 12 . . . cord-023865-6rafp3x3 166 1 It -PRON- PRP cord-023865-6rafp3x3 166 2 is be VBZ cord-023865-6rafp3x3 166 3 known know VBN cord-023865-6rafp3x3 166 4 that that IN cord-023865-6rafp3x3 166 5 the the DT cord-023865-6rafp3x3 166 6 majority majority NN cord-023865-6rafp3x3 166 7 of of IN cord-023865-6rafp3x3 166 8 cellular cellular JJ cord-023865-6rafp3x3 166 9 EF1a EF1a NNP cord-023865-6rafp3x3 166 10 is be VBZ cord-023865-6rafp3x3 166 11 bound bind VBN cord-023865-6rafp3x3 166 12 to to IN cord-023865-6rafp3x3 166 13 F F NNP cord-023865-6rafp3x3 166 14 - - HYPH cord-023865-6rafp3x3 166 15 actin actin NNP cord-023865-6rafp3x3 166 16 and and CC cord-023865-6rafp3x3 166 17 promotes promote VBZ cord-023865-6rafp3x3 166 18 F F NNP cord-023865-6rafp3x3 166 19 - - HYPH cord-023865-6rafp3x3 166 20 actin actin JJ cord-023865-6rafp3x3 166 21 bundling bundling NN cord-023865-6rafp3x3 166 22 , , , cord-023865-6rafp3x3 166 23 which which WDT cord-023865-6rafp3x3 166 24 is be VBZ cord-023865-6rafp3x3 166 25 a a DT cord-023865-6rafp3x3 166 26 key key JJ cord-023865-6rafp3x3 166 27 event event NN cord-023865-6rafp3x3 166 28 during during IN cord-023865-6rafp3x3 166 29 cytokinesis cytokinesis NN cord-023865-6rafp3x3 167 1 ( ( -LRB- cord-023865-6rafp3x3 167 2 Kurasawa Kurasawa NNP cord-023865-6rafp3x3 167 3 et et FW cord-023865-6rafp3x3 167 4 al al NNP cord-023865-6rafp3x3 167 5 . . . cord-023865-6rafp3x3 168 1 1996 1996 CD cord-023865-6rafp3x3 168 2 ; ; : cord-023865-6rafp3x3 168 3 Yang Yang NNP cord-023865-6rafp3x3 168 4 et et NNP cord-023865-6rafp3x3 168 5 al al NNP cord-023865-6rafp3x3 168 6 . . NNP cord-023865-6rafp3x3 168 7 1990 1990 CD cord-023865-6rafp3x3 168 8 ) ) -RRB- cord-023865-6rafp3x3 168 9 . . . cord-023865-6rafp3x3 169 1 Hence hence RB cord-023865-6rafp3x3 169 2 , , , cord-023865-6rafp3x3 169 3 the the DT cord-023865-6rafp3x3 169 4 authors author NNS cord-023865-6rafp3x3 169 5 tested test VBD cord-023865-6rafp3x3 169 6 whether whether IN cord-023865-6rafp3x3 169 7 N n CD cord-023865-6rafp3x3 169 8 - - HYPH cord-023865-6rafp3x3 169 9 protein protein NN cord-023865-6rafp3x3 169 10 - - HYPH cord-023865-6rafp3x3 169 11 induced induce VBN cord-023865-6rafp3x3 169 12 aggregation aggregation NN cord-023865-6rafp3x3 169 13 of of IN cord-023865-6rafp3x3 169 14 EF1a EF1a NNP cord-023865-6rafp3x3 169 15 affected affect VBD cord-023865-6rafp3x3 169 16 F F NNP cord-023865-6rafp3x3 169 17 - - HYPH cord-023865-6rafp3x3 169 18 actin actin JJ cord-023865-6rafp3x3 169 19 bundling bundling NN cord-023865-6rafp3x3 169 20 and and CC cord-023865-6rafp3x3 169 21 cytokinesis cytokinesis NN cord-023865-6rafp3x3 169 22 . . . cord-023865-6rafp3x3 170 1 As as IN cord-023865-6rafp3x3 170 2 expected expect VBN cord-023865-6rafp3x3 170 3 , , , cord-023865-6rafp3x3 170 4 they -PRON- PRP cord-023865-6rafp3x3 170 5 observed observe VBD cord-023865-6rafp3x3 170 6 significantly significantly RB cord-023865-6rafp3x3 170 7 fewer few JJR cord-023865-6rafp3x3 170 8 F F NNP cord-023865-6rafp3x3 170 9 - - HYPH cord-023865-6rafp3x3 170 10 actin actin JJ cord-023865-6rafp3x3 170 11 bundles bundle NNS cord-023865-6rafp3x3 170 12 in in IN cord-023865-6rafp3x3 170 13 N n CD cord-023865-6rafp3x3 170 14 - - HYPH cord-023865-6rafp3x3 170 15 protein protein NN cord-023865-6rafp3x3 170 16 - - HYPH cord-023865-6rafp3x3 170 17 expressing express VBG cord-023865-6rafp3x3 170 18 cells cell NNS cord-023865-6rafp3x3 170 19 . . . cord-023865-6rafp3x3 171 1 In in IN cord-023865-6rafp3x3 171 2 fact fact NN cord-023865-6rafp3x3 171 3 , , , cord-023865-6rafp3x3 171 4 a a DT cord-023865-6rafp3x3 171 5 similar similar JJ cord-023865-6rafp3x3 171 6 F f NN cord-023865-6rafp3x3 171 7 - - HYPH cord-023865-6rafp3x3 171 8 actin actin NN cord-023865-6rafp3x3 171 9 distribution distribution NN cord-023865-6rafp3x3 171 10 pattern pattern NN cord-023865-6rafp3x3 171 11 was be VBD cord-023865-6rafp3x3 171 12 also also RB cord-023865-6rafp3x3 171 13 observed observe VBN cord-023865-6rafp3x3 171 14 by by IN cord-023865-6rafp3x3 171 15 Surjit Surjit NNP cord-023865-6rafp3x3 171 16 et et NNP cord-023865-6rafp3x3 171 17 al al NNP cord-023865-6rafp3x3 171 18 . . . cord-023865-6rafp3x3 172 1 ( ( -LRB- cord-023865-6rafp3x3 172 2 2004b 2004b CD cord-023865-6rafp3x3 172 3 ) ) -RRB- cord-023865-6rafp3x3 172 4 in in IN cord-023865-6rafp3x3 172 5 COS-1 COS-1 NNP cord-023865-6rafp3x3 172 6 cells cell NNS cord-023865-6rafp3x3 172 7 . . . cord-023865-6rafp3x3 173 1 Further further RB cord-023865-6rafp3x3 173 2 , , , cord-023865-6rafp3x3 173 3 the the DT cord-023865-6rafp3x3 173 4 authors author NNS cord-023865-6rafp3x3 173 5 observed observe VBD cord-023865-6rafp3x3 173 6 multinucleated multinucleate VBD cord-023865-6rafp3x3 173 7 cells cell NNS cord-023865-6rafp3x3 173 8 in in IN cord-023865-6rafp3x3 173 9 N n CD cord-023865-6rafp3x3 173 10 - - HYPH cord-023865-6rafp3x3 173 11 protein protein NN cord-023865-6rafp3x3 173 12 - - HYPH cord-023865-6rafp3x3 173 13 expressing express VBG cord-023865-6rafp3x3 173 14 cells cell NNS cord-023865-6rafp3x3 173 15 at at IN cord-023865-6rafp3x3 173 16 a a DT cord-023865-6rafp3x3 173 17 later later JJ cord-023865-6rafp3x3 173 18 time time NN cord-023865-6rafp3x3 173 19 point point NN cord-023865-6rafp3x3 173 20 ( ( -LRB- cord-023865-6rafp3x3 173 21 72 72 CD cord-023865-6rafp3x3 173 22 h h NN cord-023865-6rafp3x3 173 23 post post NN cord-023865-6rafp3x3 173 24 - - JJ cord-023865-6rafp3x3 173 25 transfection transfection JJ cord-023865-6rafp3x3 173 26 ) ) -RRB- cord-023865-6rafp3x3 173 27 , , , cord-023865-6rafp3x3 173 28 indicating indicate VBG cord-023865-6rafp3x3 173 29 inhibition inhibition NN cord-023865-6rafp3x3 173 30 of of IN cord-023865-6rafp3x3 173 31 cytokinesis cytokinesis NN cord-023865-6rafp3x3 173 32 in in IN cord-023865-6rafp3x3 173 33 those those DT cord-023865-6rafp3x3 173 34 cells cell NNS cord-023865-6rafp3x3 173 35 . . . cord-023865-6rafp3x3 174 1 Specificity specificity NN cord-023865-6rafp3x3 174 2 of of IN cord-023865-6rafp3x3 174 3 the the DT cord-023865-6rafp3x3 174 4 above above JJ cord-023865-6rafp3x3 174 5 data data NN cord-023865-6rafp3x3 174 6 has have VBZ cord-023865-6rafp3x3 174 7 been be VBN cord-023865-6rafp3x3 174 8 confirmed confirm VBN cord-023865-6rafp3x3 174 9 by by IN cord-023865-6rafp3x3 174 10 the the DT cord-023865-6rafp3x3 174 11 use use NN cord-023865-6rafp3x3 174 12 of of IN cord-023865-6rafp3x3 174 13 different different JJ cord-023865-6rafp3x3 174 14 deletion deletion NN cord-023865-6rafp3x3 174 15 mutants mutant NNS cord-023865-6rafp3x3 174 16 of of IN cord-023865-6rafp3x3 174 17 the the DT cord-023865-6rafp3x3 174 18 N n NN cord-023865-6rafp3x3 174 19 - - HYPH cord-023865-6rafp3x3 174 20 protein protein NN cord-023865-6rafp3x3 174 21 , , , cord-023865-6rafp3x3 174 22 in in IN cord-023865-6rafp3x3 174 23 which which WDT cord-023865-6rafp3x3 174 24 only only RB cord-023865-6rafp3x3 174 25 the the DT cord-023865-6rafp3x3 174 26 C C NNP cord-023865-6rafp3x3 174 27 - - HYPH cord-023865-6rafp3x3 174 28 terminal terminal NN cord-023865-6rafp3x3 174 29 domain domain NN cord-023865-6rafp3x3 174 30 of of IN cord-023865-6rafp3x3 174 31 the the DT cord-023865-6rafp3x3 174 32 N N NNP cord-023865-6rafp3x3 174 33 - - HYPH cord-023865-6rafp3x3 174 34 protein protein NN cord-023865-6rafp3x3 174 35 ( ( -LRB- cord-023865-6rafp3x3 174 36 responsible responsible JJ cord-023865-6rafp3x3 174 37 for for IN cord-023865-6rafp3x3 174 38 binding bind VBG cord-023865-6rafp3x3 174 39 with with IN cord-023865-6rafp3x3 174 40 EF1a EF1a NNP cord-023865-6rafp3x3 174 41 ) ) -RRB- cord-023865-6rafp3x3 174 42 was be VBD cord-023865-6rafp3x3 174 43 able able JJ cord-023865-6rafp3x3 174 44 to to TO cord-023865-6rafp3x3 174 45 reproduce reproduce VB cord-023865-6rafp3x3 174 46 the the DT cord-023865-6rafp3x3 174 47 above above JJ cord-023865-6rafp3x3 174 48 results result NNS cord-023865-6rafp3x3 174 49 . . . cord-023865-6rafp3x3 175 1 Thus thus RB cord-023865-6rafp3x3 175 2 , , , cord-023865-6rafp3x3 175 3 it -PRON- PRP cord-023865-6rafp3x3 175 4 has have VBZ cord-023865-6rafp3x3 175 5 been be VBN cord-023865-6rafp3x3 175 6 suggested suggest VBN cord-023865-6rafp3x3 175 7 that that IN cord-023865-6rafp3x3 175 8 EF1a EF1a NNP cord-023865-6rafp3x3 175 9 binding bind VBG cord-023865-6rafp3x3 175 10 by by IN cord-023865-6rafp3x3 175 11 the the DT cord-023865-6rafp3x3 175 12 N n CD cord-023865-6rafp3x3 175 13 - - HYPH cord-023865-6rafp3x3 175 14 protein protein NN cord-023865-6rafp3x3 175 15 leads lead VBZ cord-023865-6rafp3x3 175 16 to to IN cord-023865-6rafp3x3 175 17 its -PRON- PRP$ cord-023865-6rafp3x3 175 18 aggregation aggregation NN cord-023865-6rafp3x3 175 19 , , , cord-023865-6rafp3x3 175 20 resulting result VBG cord-023865-6rafp3x3 175 21 in in IN cord-023865-6rafp3x3 175 22 inhibition inhibition NN cord-023865-6rafp3x3 175 23 of of IN cord-023865-6rafp3x3 175 24 F F NNP cord-023865-6rafp3x3 175 25 - - HYPH cord-023865-6rafp3x3 175 26 actin actin JJ cord-023865-6rafp3x3 175 27 bundling bundling NN cord-023865-6rafp3x3 175 28 and and CC cord-023865-6rafp3x3 175 29 subsequent subsequent JJ cord-023865-6rafp3x3 175 30 blocking blocking NN cord-023865-6rafp3x3 175 31 of of IN cord-023865-6rafp3x3 175 32 cytokinesis cytokinesis NN cord-023865-6rafp3x3 175 33 . . . cord-023865-6rafp3x3 176 1 EF1a EF1a NNP cord-023865-6rafp3x3 176 2 is be VBZ cord-023865-6rafp3x3 176 3 known know VBN cord-023865-6rafp3x3 176 4 to to TO cord-023865-6rafp3x3 176 5 play play VB cord-023865-6rafp3x3 176 6 a a DT cord-023865-6rafp3x3 176 7 key key JJ cord-023865-6rafp3x3 176 8 role role NN cord-023865-6rafp3x3 176 9 during during IN cord-023865-6rafp3x3 176 10 the the DT cord-023865-6rafp3x3 176 11 peptide peptide NN cord-023865-6rafp3x3 176 12 elongation elongation NN cord-023865-6rafp3x3 176 13 stage stage NN cord-023865-6rafp3x3 176 14 of of IN cord-023865-6rafp3x3 176 15 translation translation NN cord-023865-6rafp3x3 176 16 . . . cord-023865-6rafp3x3 177 1 Therefore therefore RB cord-023865-6rafp3x3 177 2 , , , cord-023865-6rafp3x3 177 3 it -PRON- PRP cord-023865-6rafp3x3 177 4 is be VBZ cord-023865-6rafp3x3 177 5 an an DT cord-023865-6rafp3x3 177 6 attractive attractive JJ cord-023865-6rafp3x3 177 7 candidate candidate NN cord-023865-6rafp3x3 177 8 for for IN cord-023865-6rafp3x3 177 9 pathogen pathogen NN cord-023865-6rafp3x3 177 10 proteins protein NNS cord-023865-6rafp3x3 177 11 to to TO cord-023865-6rafp3x3 177 12 manipulate manipulate VB cord-023865-6rafp3x3 177 13 its -PRON- PRP$ cord-023865-6rafp3x3 177 14 activity activity NN cord-023865-6rafp3x3 177 15 in in IN cord-023865-6rafp3x3 177 16 order order NN cord-023865-6rafp3x3 177 17 to to TO cord-023865-6rafp3x3 177 18 skew skew VB cord-023865-6rafp3x3 177 19 the the DT cord-023865-6rafp3x3 177 20 host host NN cord-023865-6rafp3x3 177 21 translation translation NN cord-023865-6rafp3x3 177 22 machinery machinery NN cord-023865-6rafp3x3 177 23 . . . cord-023865-6rafp3x3 178 1 For for IN cord-023865-6rafp3x3 178 2 example example NN cord-023865-6rafp3x3 178 3 , , , cord-023865-6rafp3x3 178 4 HIV HIV NNP cord-023865-6rafp3x3 178 5 - - HYPH cord-023865-6rafp3x3 178 6 type type NN cord-023865-6rafp3x3 178 7 1 1 CD cord-023865-6rafp3x3 178 8 gag gag NN cord-023865-6rafp3x3 178 9 polyprotein polyprotein NN cord-023865-6rafp3x3 178 10 has have VBZ cord-023865-6rafp3x3 178 11 been be VBN cord-023865-6rafp3x3 178 12 shown show VBN cord-023865-6rafp3x3 178 13 to to TO cord-023865-6rafp3x3 178 14 interact interact VB cord-023865-6rafp3x3 178 15 with with IN cord-023865-6rafp3x3 178 16 EF1a EF1a NNP cord-023865-6rafp3x3 178 17 and and CC cord-023865-6rafp3x3 178 18 impair impair VB cord-023865-6rafp3x3 178 19 translation translation NN cord-023865-6rafp3x3 178 20 in in IN cord-023865-6rafp3x3 178 21 vitro vitro FW cord-023865-6rafp3x3 178 22 ( ( -LRB- cord-023865-6rafp3x3 178 23 Cimarelli Cimarelli NNP cord-023865-6rafp3x3 178 24 and and CC cord-023865-6rafp3x3 178 25 Luban Luban NNP cord-023865-6rafp3x3 178 26 1999 1999 CD cord-023865-6rafp3x3 178 27 ) ) -RRB- cord-023865-6rafp3x3 178 28 . . . cord-023865-6rafp3x3 179 1 Since since IN cord-023865-6rafp3x3 179 2 Zhou Zhou NNP cord-023865-6rafp3x3 179 3 et et NNP cord-023865-6rafp3x3 179 4 al al NNP cord-023865-6rafp3x3 179 5 . . . cord-023865-6rafp3x3 180 1 ( ( -LRB- cord-023865-6rafp3x3 180 2 2008 2008 CD cord-023865-6rafp3x3 180 3 ) ) -RRB- cord-023865-6rafp3x3 180 4 observed observe VBD cord-023865-6rafp3x3 180 5 an an DT cord-023865-6rafp3x3 180 6 interaction interaction NN cord-023865-6rafp3x3 180 7 between between IN cord-023865-6rafp3x3 180 8 EF1a EF1a NNP cord-023865-6rafp3x3 180 9 and and CC cord-023865-6rafp3x3 180 10 SARS SARS NNP cord-023865-6rafp3x3 180 11 - - HYPH cord-023865-6rafp3x3 180 12 CoV CoV NNP cord-023865-6rafp3x3 180 13 N N NNP cord-023865-6rafp3x3 180 14 - - HYPH cord-023865-6rafp3x3 180 15 protein protein NN cord-023865-6rafp3x3 180 16 , , , cord-023865-6rafp3x3 180 17 they -PRON- PRP cord-023865-6rafp3x3 180 18 further further RB cord-023865-6rafp3x3 180 19 tested test VBD cord-023865-6rafp3x3 180 20 whether whether IN cord-023865-6rafp3x3 180 21 it -PRON- PRP cord-023865-6rafp3x3 180 22 interfered interfere VBD cord-023865-6rafp3x3 180 23 with with IN cord-023865-6rafp3x3 180 24 the the DT cord-023865-6rafp3x3 180 25 host host NN cord-023865-6rafp3x3 180 26 translation translation NN cord-023865-6rafp3x3 180 27 machinery machinery NN cord-023865-6rafp3x3 180 28 . . . cord-023865-6rafp3x3 181 1 Indeed indeed RB cord-023865-6rafp3x3 181 2 , , , cord-023865-6rafp3x3 181 3 presence presence NN cord-023865-6rafp3x3 181 4 of of IN cord-023865-6rafp3x3 181 5 the the DT cord-023865-6rafp3x3 181 6 N N NNP cord-023865-6rafp3x3 181 7 - - HYPH cord-023865-6rafp3x3 181 8 protein protein NN cord-023865-6rafp3x3 181 9 inhibited inhibit VBD cord-023865-6rafp3x3 181 10 total total JJ cord-023865-6rafp3x3 181 11 cellular cellular JJ cord-023865-6rafp3x3 181 12 translation translation NN cord-023865-6rafp3x3 181 13 , , , cord-023865-6rafp3x3 181 14 both both CC cord-023865-6rafp3x3 181 15 in in IN cord-023865-6rafp3x3 181 16 vitro vitro FW cord-023865-6rafp3x3 181 17 and and CC cord-023865-6rafp3x3 181 18 in in IN cord-023865-6rafp3x3 181 19 vivo vivo NNP cord-023865-6rafp3x3 181 20 , , , cord-023865-6rafp3x3 181 21 in in IN cord-023865-6rafp3x3 181 22 a a DT cord-023865-6rafp3x3 181 23 dose dose NN cord-023865-6rafp3x3 181 24 - - HYPH cord-023865-6rafp3x3 181 25 dependent dependent JJ cord-023865-6rafp3x3 181 26 manner manner NN cord-023865-6rafp3x3 181 27 . . . cord-023865-6rafp3x3 182 1 Moreover moreover RB cord-023865-6rafp3x3 182 2 , , , cord-023865-6rafp3x3 182 3 exogenous exogenous JJ cord-023865-6rafp3x3 182 4 addition addition NN cord-023865-6rafp3x3 182 5 of of IN cord-023865-6rafp3x3 182 6 excess excess JJ cord-023865-6rafp3x3 182 7 EF1a EF1a NNP cord-023865-6rafp3x3 182 8 could could MD cord-023865-6rafp3x3 182 9 reverse reverse VB cord-023865-6rafp3x3 182 10 the the DT cord-023865-6rafp3x3 182 11 N N NNP cord-023865-6rafp3x3 182 12 - - HYPH cord-023865-6rafp3x3 182 13 proteininduced proteininduce VBN cord-023865-6rafp3x3 182 14 translation translation NN cord-023865-6rafp3x3 182 15 inhibition inhibition NN cord-023865-6rafp3x3 182 16 , , , cord-023865-6rafp3x3 182 17 thus thus RB cord-023865-6rafp3x3 182 18 suggesting suggest VBG cord-023865-6rafp3x3 182 19 that that IN cord-023865-6rafp3x3 182 20 N n NN cord-023865-6rafp3x3 182 21 - - HYPH cord-023865-6rafp3x3 182 22 protein protein NN cord-023865-6rafp3x3 182 23 exerts exert VBZ cord-023865-6rafp3x3 182 24 its -PRON- PRP$ cord-023865-6rafp3x3 182 25 effect effect NN cord-023865-6rafp3x3 182 26 by by IN cord-023865-6rafp3x3 182 27 interfering interfere VBG cord-023865-6rafp3x3 182 28 with with IN cord-023865-6rafp3x3 182 29 EF1a EF1a NNP cord-023865-6rafp3x3 182 30 function function NN cord-023865-6rafp3x3 182 31 . . . cord-023865-6rafp3x3 183 1 However however RB cord-023865-6rafp3x3 183 2 , , , cord-023865-6rafp3x3 183 3 it -PRON- PRP cord-023865-6rafp3x3 183 4 remains remain VBZ cord-023865-6rafp3x3 183 5 to to TO cord-023865-6rafp3x3 183 6 be be VB cord-023865-6rafp3x3 183 7 confirmed confirm VBN cord-023865-6rafp3x3 183 8 whether whether IN cord-023865-6rafp3x3 183 9 a a DT cord-023865-6rafp3x3 183 10 similar similar JJ cord-023865-6rafp3x3 183 11 effect effect NN cord-023865-6rafp3x3 183 12 is be VBZ cord-023865-6rafp3x3 183 13 recapitulated recapitulate VBN cord-023865-6rafp3x3 183 14 in in IN cord-023865-6rafp3x3 183 15 vivo vivo NN cord-023865-6rafp3x3 183 16 . . . cord-023865-6rafp3x3 184 1 Production production NN cord-023865-6rafp3x3 184 2 of of IN cord-023865-6rafp3x3 184 3 interferon interferon NN cord-023865-6rafp3x3 184 4 ( ( -LRB- cord-023865-6rafp3x3 184 5 IFN IFN NNP cord-023865-6rafp3x3 184 6 ) ) -RRB- cord-023865-6rafp3x3 184 7 is be VBZ cord-023865-6rafp3x3 184 8 one one CD cord-023865-6rafp3x3 184 9 of of IN cord-023865-6rafp3x3 184 10 the the DT cord-023865-6rafp3x3 184 11 primary primary JJ cord-023865-6rafp3x3 184 12 host host NN cord-023865-6rafp3x3 184 13 defense defense NN cord-023865-6rafp3x3 184 14 mechanisms mechanism NNS cord-023865-6rafp3x3 184 15 . . . cord-023865-6rafp3x3 185 1 However however RB cord-023865-6rafp3x3 185 2 , , , cord-023865-6rafp3x3 185 3 SARS SARS NNP cord-023865-6rafp3x3 185 4 - - HYPH cord-023865-6rafp3x3 185 5 CoV CoV NNP cord-023865-6rafp3x3 185 6 infection infection NN cord-023865-6rafp3x3 185 7 does do VBZ cord-023865-6rafp3x3 185 8 not not RB cord-023865-6rafp3x3 185 9 result result VB cord-023865-6rafp3x3 185 10 in in IN cord-023865-6rafp3x3 185 11 IFN IFN NNP cord-023865-6rafp3x3 185 12 production production NN cord-023865-6rafp3x3 185 13 . . . cord-023865-6rafp3x3 186 1 Nevertheless nevertheless RB cord-023865-6rafp3x3 186 2 , , , cord-023865-6rafp3x3 186 3 pretreatment pretreatment NN cord-023865-6rafp3x3 186 4 of of IN cord-023865-6rafp3x3 186 5 cells cell NNS cord-023865-6rafp3x3 186 6 with with IN cord-023865-6rafp3x3 186 7 IFN IFN NNP cord-023865-6rafp3x3 186 8 blocks block VBZ cord-023865-6rafp3x3 186 9 SARS SARS NNP cord-023865-6rafp3x3 186 10 - - HYPH cord-023865-6rafp3x3 186 11 CoV CoV NNP cord-023865-6rafp3x3 186 12 infection infection NN cord-023865-6rafp3x3 187 1 ( ( -LRB- cord-023865-6rafp3x3 187 2 Spiegel Spiegel NNP cord-023865-6rafp3x3 187 3 et et NNP cord-023865-6rafp3x3 187 4 al al NNP cord-023865-6rafp3x3 187 5 . . . cord-023865-6rafp3x3 187 6 2005 2005 CD cord-023865-6rafp3x3 188 1 ; ; : cord-023865-6rafp3x3 188 2 Zheng Zheng NNP cord-023865-6rafp3x3 188 3 et et NNP cord-023865-6rafp3x3 188 4 al al NNP cord-023865-6rafp3x3 188 5 . . . cord-023865-6rafp3x3 188 6 2004 2004 CD cord-023865-6rafp3x3 188 7 ) ) -RRB- cord-023865-6rafp3x3 188 8 . . . cord-023865-6rafp3x3 189 1 Based base VBN cord-023865-6rafp3x3 189 2 on on IN cord-023865-6rafp3x3 189 3 this this DT cord-023865-6rafp3x3 189 4 observation observation NN cord-023865-6rafp3x3 189 5 , , , cord-023865-6rafp3x3 189 6 Palese Palese NNP cord-023865-6rafp3x3 189 7 's 's POS cord-023865-6rafp3x3 189 8 laboratory laboratory NN cord-023865-6rafp3x3 189 9 has have VBZ cord-023865-6rafp3x3 189 10 studied study VBN cord-023865-6rafp3x3 189 11 the the DT cord-023865-6rafp3x3 189 12 IFN IFN NNP cord-023865-6rafp3x3 189 13 inhibitory inhibitory JJ cord-023865-6rafp3x3 189 14 property property NN cord-023865-6rafp3x3 189 15 of of IN cord-023865-6rafp3x3 189 16 different different JJ cord-023865-6rafp3x3 189 17 SARS SARS NNP cord-023865-6rafp3x3 189 18 - - HYPH cord-023865-6rafp3x3 189 19 CoV cov NN cord-023865-6rafp3x3 189 20 proteins protein NNS cord-023865-6rafp3x3 189 21 , , , cord-023865-6rafp3x3 189 22 which which WDT cord-023865-6rafp3x3 189 23 revealed reveal VBD cord-023865-6rafp3x3 189 24 that that IN cord-023865-6rafp3x3 189 25 ORF3 ORF3 NNP cord-023865-6rafp3x3 189 26 , , , cord-023865-6rafp3x3 189 27 ORF6 ORF6 NNP cord-023865-6rafp3x3 189 28 as as RB cord-023865-6rafp3x3 189 29 well well RB cord-023865-6rafp3x3 189 30 as as IN cord-023865-6rafp3x3 189 31 the the DT cord-023865-6rafp3x3 189 32 N N NNP cord-023865-6rafp3x3 189 33 - - HYPH cord-023865-6rafp3x3 189 34 protein protein NN cord-023865-6rafp3x3 189 35 have have VBP cord-023865-6rafp3x3 189 36 the the DT cord-023865-6rafp3x3 189 37 ability ability NN cord-023865-6rafp3x3 189 38 to to TO cord-023865-6rafp3x3 189 39 independently independently RB cord-023865-6rafp3x3 189 40 inhibit inhibit VB cord-023865-6rafp3x3 189 41 IFN IFN NNP cord-023865-6rafp3x3 189 42 production production NN cord-023865-6rafp3x3 189 43 through through IN cord-023865-6rafp3x3 189 44 different different JJ cord-023865-6rafp3x3 189 45 mechanisms mechanism NNS cord-023865-6rafp3x3 189 46 . . . cord-023865-6rafp3x3 190 1 The the DT cord-023865-6rafp3x3 190 2 N N NNP cord-023865-6rafp3x3 190 3 - - HYPH cord-023865-6rafp3x3 190 4 protein protein NN cord-023865-6rafp3x3 190 5 was be VBD cord-023865-6rafp3x3 190 6 found find VBN cord-023865-6rafp3x3 190 7 to to TO cord-023865-6rafp3x3 190 8 inhibit inhibit VB cord-023865-6rafp3x3 190 9 the the DT cord-023865-6rafp3x3 190 10 activity activity NN cord-023865-6rafp3x3 190 11 of of IN cord-023865-6rafp3x3 190 12 IRF3 IRF3 NNP cord-023865-6rafp3x3 190 13 and and CC cord-023865-6rafp3x3 190 14 NFkB NFkB NNP cord-023865-6rafp3x3 190 15 in in IN cord-023865-6rafp3x3 190 16 host host NN cord-023865-6rafp3x3 190 17 cells cell NNS cord-023865-6rafp3x3 190 18 , , , cord-023865-6rafp3x3 190 19 resulting result VBG cord-023865-6rafp3x3 190 20 in in IN cord-023865-6rafp3x3 190 21 inhibition inhibition NN cord-023865-6rafp3x3 190 22 of of IN cord-023865-6rafp3x3 190 23 IFN IFN NNP cord-023865-6rafp3x3 190 24 synthesis synthesis NN cord-023865-6rafp3x3 190 25 . . . cord-023865-6rafp3x3 191 1 IRF3 irf3 NN cord-023865-6rafp3x3 191 2 activity activity NN cord-023865-6rafp3x3 191 3 was be VBD cord-023865-6rafp3x3 191 4 also also RB cord-023865-6rafp3x3 191 5 blocked block VBN cord-023865-6rafp3x3 191 6 by by IN cord-023865-6rafp3x3 191 7 ORF3 ORF3 NNP cord-023865-6rafp3x3 191 8 , , , cord-023865-6rafp3x3 191 9 ORF6 ORF6 NNP cord-023865-6rafp3x3 191 10 proteins protein NNS cord-023865-6rafp3x3 191 11 , , , cord-023865-6rafp3x3 191 12 but but CC cord-023865-6rafp3x3 191 13 inhibition inhibition NN cord-023865-6rafp3x3 191 14 of of IN cord-023865-6rafp3x3 191 15 NFkB nfkb JJ cord-023865-6rafp3x3 191 16 activity activity NN cord-023865-6rafp3x3 191 17 was be VBD cord-023865-6rafp3x3 191 18 a a DT cord-023865-6rafp3x3 191 19 property property NN cord-023865-6rafp3x3 191 20 unique unique JJ cord-023865-6rafp3x3 191 21 to to IN cord-023865-6rafp3x3 191 22 the the DT cord-023865-6rafp3x3 191 23 N n NN cord-023865-6rafp3x3 191 24 - - HYPH cord-023865-6rafp3x3 191 25 protein protein NN cord-023865-6rafp3x3 191 26 . . . cord-023865-6rafp3x3 192 1 In in IN cord-023865-6rafp3x3 192 2 addition addition NN cord-023865-6rafp3x3 192 3 , , , cord-023865-6rafp3x3 192 4 ORF3 ORF3 NNP cord-023865-6rafp3x3 192 5 , , , cord-023865-6rafp3x3 192 6 ORF6 ORF6 NNP cord-023865-6rafp3x3 192 7 proteins protein NNS cord-023865-6rafp3x3 192 8 were be VBD cord-023865-6rafp3x3 192 9 able able JJ cord-023865-6rafp3x3 192 10 to to TO cord-023865-6rafp3x3 192 11 block block VB cord-023865-6rafp3x3 192 12 STAT1 stat1 NN cord-023865-6rafp3x3 192 13 activity activity NN cord-023865-6rafp3x3 192 14 through through IN cord-023865-6rafp3x3 192 15 different different JJ cord-023865-6rafp3x3 192 16 mechanisms mechanism NNS cord-023865-6rafp3x3 193 1 ( ( -LRB- cord-023865-6rafp3x3 193 2 Kopecky Kopecky NNP cord-023865-6rafp3x3 193 3 - - HYPH cord-023865-6rafp3x3 193 4 Bromberg Bromberg NNP cord-023865-6rafp3x3 193 5 et et NNP cord-023865-6rafp3x3 193 6 al al NNP cord-023865-6rafp3x3 193 7 . . NNP cord-023865-6rafp3x3 193 8 2007 2007 CD cord-023865-6rafp3x3 193 9 ) ) -RRB- cord-023865-6rafp3x3 193 10 . . . cord-023865-6rafp3x3 194 1 All all PDT cord-023865-6rafp3x3 194 2 these these DT cord-023865-6rafp3x3 194 3 data datum NNS cord-023865-6rafp3x3 194 4 suggest suggest VBP cord-023865-6rafp3x3 194 5 that that IN cord-023865-6rafp3x3 194 6 SARS SARS NNP cord-023865-6rafp3x3 194 7 - - HYPH cord-023865-6rafp3x3 194 8 CoV CoV NNP cord-023865-6rafp3x3 194 9 may may MD cord-023865-6rafp3x3 194 10 employ employ VB cord-023865-6rafp3x3 194 11 multiple multiple JJ cord-023865-6rafp3x3 194 12 factors factor NNS cord-023865-6rafp3x3 194 13 to to TO cord-023865-6rafp3x3 194 14 check check VB cord-023865-6rafp3x3 194 15 the the DT cord-023865-6rafp3x3 194 16 activity activity NN cord-023865-6rafp3x3 194 17 of of IN cord-023865-6rafp3x3 194 18 the the DT cord-023865-6rafp3x3 194 19 host host NN cord-023865-6rafp3x3 194 20 immune immune JJ cord-023865-6rafp3x3 194 21 system system NN cord-023865-6rafp3x3 194 22 and and CC cord-023865-6rafp3x3 194 23 N n NN cord-023865-6rafp3x3 194 24 - - HYPH cord-023865-6rafp3x3 194 25 protein protein NN cord-023865-6rafp3x3 194 26 may may MD cord-023865-6rafp3x3 194 27 be be VB cord-023865-6rafp3x3 194 28 one one CD cord-023865-6rafp3x3 194 29 of of IN cord-023865-6rafp3x3 194 30 the the DT cord-023865-6rafp3x3 194 31 major major JJ cord-023865-6rafp3x3 194 32 partners partner NNS cord-023865-6rafp3x3 194 33 in in IN cord-023865-6rafp3x3 194 34 this this DT cord-023865-6rafp3x3 194 35 process process NN cord-023865-6rafp3x3 194 36 . . . cord-023865-6rafp3x3 195 1 It -PRON- PRP cord-023865-6rafp3x3 195 2 may may MD cord-023865-6rafp3x3 195 3 be be VB cord-023865-6rafp3x3 195 4 possible possible JJ cord-023865-6rafp3x3 195 5 that that IN cord-023865-6rafp3x3 195 6 these these DT cord-023865-6rafp3x3 195 7 different different JJ cord-023865-6rafp3x3 195 8 factors factor NNS cord-023865-6rafp3x3 195 9 act act VBP cord-023865-6rafp3x3 195 10 independently independently RB cord-023865-6rafp3x3 195 11 during during IN cord-023865-6rafp3x3 195 12 different different JJ cord-023865-6rafp3x3 195 13 stages stage NNS cord-023865-6rafp3x3 195 14 of of IN cord-023865-6rafp3x3 195 15 the the DT cord-023865-6rafp3x3 195 16 viral viral JJ cord-023865-6rafp3x3 195 17 life life NN cord-023865-6rafp3x3 195 18 cycle cycle NN cord-023865-6rafp3x3 195 19 . . . cord-023865-6rafp3x3 196 1 In in IN cord-023865-6rafp3x3 196 2 that that DT cord-023865-6rafp3x3 196 3 case case NN cord-023865-6rafp3x3 196 4 , , , cord-023865-6rafp3x3 196 5 regulatory regulatory JJ cord-023865-6rafp3x3 196 6 activity activity NN cord-023865-6rafp3x3 196 7 of of IN cord-023865-6rafp3x3 196 8 the the DT cord-023865-6rafp3x3 196 9 N n NN cord-023865-6rafp3x3 196 10 - - HYPH cord-023865-6rafp3x3 196 11 protein protein NN cord-023865-6rafp3x3 196 12 will will MD cord-023865-6rafp3x3 196 13 be be VB cord-023865-6rafp3x3 196 14 as as RB cord-023865-6rafp3x3 196 15 indispensible indispensible JJ cord-023865-6rafp3x3 196 16 as as IN cord-023865-6rafp3x3 196 17 its -PRON- PRP$ cord-023865-6rafp3x3 196 18 structural structural JJ cord-023865-6rafp3x3 196 19 activity activity NN cord-023865-6rafp3x3 196 20 . . . cord-023865-6rafp3x3 197 1 During during IN cord-023865-6rafp3x3 197 2 the the DT cord-023865-6rafp3x3 197 3 SARS SARS NNP cord-023865-6rafp3x3 197 4 outbreak outbreak NN cord-023865-6rafp3x3 197 5 , , , cord-023865-6rafp3x3 197 6 a a DT cord-023865-6rafp3x3 197 7 large large JJ cord-023865-6rafp3x3 197 8 number number NN cord-023865-6rafp3x3 197 9 of of IN cord-023865-6rafp3x3 197 10 patients patient NNS cord-023865-6rafp3x3 197 11 developed develop VBD cord-023865-6rafp3x3 197 12 severe severe JJ cord-023865-6rafp3x3 197 13 inflammation inflammation NN cord-023865-6rafp3x3 197 14 of of IN cord-023865-6rafp3x3 197 15 the the DT cord-023865-6rafp3x3 197 16 lungs lung NNS cord-023865-6rafp3x3 197 17 , , , cord-023865-6rafp3x3 197 18 which which WDT cord-023865-6rafp3x3 197 19 subsequently subsequently RB cord-023865-6rafp3x3 197 20 led lead VBD cord-023865-6rafp3x3 197 21 to to IN cord-023865-6rafp3x3 197 22 acute acute JJ cord-023865-6rafp3x3 197 23 respiratory respiratory JJ cord-023865-6rafp3x3 197 24 distress distress NN cord-023865-6rafp3x3 197 25 syndrome syndrome NN cord-023865-6rafp3x3 198 1 ( ( -LRB- cord-023865-6rafp3x3 198 2 Ding Ding NNP cord-023865-6rafp3x3 198 3 et et FW cord-023865-6rafp3x3 198 4 al al NNP cord-023865-6rafp3x3 198 5 . . . cord-023865-6rafp3x3 199 1 2003 2003 CD cord-023865-6rafp3x3 199 2 ; ; : cord-023865-6rafp3x3 199 3 Nicholls Nicholls NNP cord-023865-6rafp3x3 199 4 et et NNP cord-023865-6rafp3x3 199 5 al al NNP cord-023865-6rafp3x3 199 6 . . NNP cord-023865-6rafp3x3 199 7 2003 2003 CD cord-023865-6rafp3x3 199 8 ) ) -RRB- cord-023865-6rafp3x3 199 9 . . . cord-023865-6rafp3x3 200 1 Acute acute JJ cord-023865-6rafp3x3 200 2 respiratory respiratory JJ cord-023865-6rafp3x3 200 3 distress distress NN cord-023865-6rafp3x3 200 4 syndrome syndrome NN cord-023865-6rafp3x3 200 5 is be VBZ cord-023865-6rafp3x3 200 6 characterized characterize VBN cord-023865-6rafp3x3 200 7 by by IN cord-023865-6rafp3x3 200 8 pulmonary pulmonary JJ cord-023865-6rafp3x3 200 9 fibrosis fibrosis NN cord-023865-6rafp3x3 200 10 , , , cord-023865-6rafp3x3 200 11 which which WDT cord-023865-6rafp3x3 200 12 results result VBZ cord-023865-6rafp3x3 200 13 in in IN cord-023865-6rafp3x3 200 14 lung lung NN cord-023865-6rafp3x3 200 15 failure failure NN cord-023865-6rafp3x3 200 16 and and CC cord-023865-6rafp3x3 200 17 subsequent subsequent JJ cord-023865-6rafp3x3 200 18 death death NN cord-023865-6rafp3x3 200 19 of of IN cord-023865-6rafp3x3 200 20 the the DT cord-023865-6rafp3x3 200 21 patient patient NN cord-023865-6rafp3x3 200 22 . . . cord-023865-6rafp3x3 201 1 The the DT cord-023865-6rafp3x3 201 2 TGFb TGFb NNPS cord-023865-6rafp3x3 201 3 signaling signal VBG cord-023865-6rafp3x3 201 4 pathway pathway NN cord-023865-6rafp3x3 201 5 plays play VBZ cord-023865-6rafp3x3 201 6 a a DT cord-023865-6rafp3x3 201 7 critical critical JJ cord-023865-6rafp3x3 201 8 role role NN cord-023865-6rafp3x3 201 9 in in IN cord-023865-6rafp3x3 201 10 pulmonary pulmonary JJ cord-023865-6rafp3x3 201 11 fibrosis fibrosis NN cord-023865-6rafp3x3 201 12 ( ( -LRB- cord-023865-6rafp3x3 201 13 Roberts Roberts NNP cord-023865-6rafp3x3 201 14 et et NNP cord-023865-6rafp3x3 201 15 al al NNP cord-023865-6rafp3x3 201 16 . . . cord-023865-6rafp3x3 201 17 2006 2006 CD cord-023865-6rafp3x3 201 18 ; ; : cord-023865-6rafp3x3 201 19 Border Border NNP cord-023865-6rafp3x3 201 20 and and CC cord-023865-6rafp3x3 201 21 Noble Noble NNP cord-023865-6rafp3x3 201 22 1994 1994 CD cord-023865-6rafp3x3 201 23 ) ) -RRB- cord-023865-6rafp3x3 201 24 . . . cord-023865-6rafp3x3 202 1 It -PRON- PRP cord-023865-6rafp3x3 202 2 enhances enhance VBZ cord-023865-6rafp3x3 202 3 the the DT cord-023865-6rafp3x3 202 4 expression expression NN cord-023865-6rafp3x3 202 5 of of IN cord-023865-6rafp3x3 202 6 extracellular extracellular JJ cord-023865-6rafp3x3 202 7 matrix matrix NN cord-023865-6rafp3x3 202 8 ( ( -LRB- cord-023865-6rafp3x3 202 9 ECM ECM NNP cord-023865-6rafp3x3 202 10 ) ) -RRB- cord-023865-6rafp3x3 202 11 proteins protein NNS cord-023865-6rafp3x3 202 12 , , , cord-023865-6rafp3x3 202 13 accelerates accelerate VBZ cord-023865-6rafp3x3 202 14 the the DT cord-023865-6rafp3x3 202 15 secretion secretion NN cord-023865-6rafp3x3 202 16 of of IN cord-023865-6rafp3x3 202 17 protease protease NN cord-023865-6rafp3x3 202 18 inhibitors inhibitor NNS cord-023865-6rafp3x3 202 19 and and CC cord-023865-6rafp3x3 202 20 reduces reduce VBZ cord-023865-6rafp3x3 202 21 the the DT cord-023865-6rafp3x3 202 22 secretion secretion NN cord-023865-6rafp3x3 202 23 of of IN cord-023865-6rafp3x3 202 24 proteases protease NNS cord-023865-6rafp3x3 202 25 , , , cord-023865-6rafp3x3 202 26 thereby thereby RB cord-023865-6rafp3x3 202 27 leading lead VBG cord-023865-6rafp3x3 202 28 to to IN cord-023865-6rafp3x3 202 29 deposition deposition NN cord-023865-6rafp3x3 202 30 of of IN cord-023865-6rafp3x3 202 31 ECM ECM NNP cord-023865-6rafp3x3 202 32 proteins protein NNS cord-023865-6rafp3x3 202 33 . . . cord-023865-6rafp3x3 203 1 TGFb TGFb NNP cord-023865-6rafp3x3 203 2 may may MD cord-023865-6rafp3x3 203 3 also also RB cord-023865-6rafp3x3 203 4 induce induce VB cord-023865-6rafp3x3 203 5 pulmonary pulmonary JJ cord-023865-6rafp3x3 203 6 fibrosis fibrosis NN cord-023865-6rafp3x3 203 7 directly directly RB cord-023865-6rafp3x3 203 8 by by IN cord-023865-6rafp3x3 203 9 stimulating stimulate VBG cord-023865-6rafp3x3 203 10 chemotactic chemotactic JJ cord-023865-6rafp3x3 203 11 migration migration NN cord-023865-6rafp3x3 203 12 and and CC cord-023865-6rafp3x3 203 13 proliferation proliferation NN cord-023865-6rafp3x3 203 14 of of IN cord-023865-6rafp3x3 203 15 fibroblasts fibroblast NNS cord-023865-6rafp3x3 203 16 as as RB cord-023865-6rafp3x3 203 17 well well RB cord-023865-6rafp3x3 203 18 as as IN cord-023865-6rafp3x3 203 19 by by IN cord-023865-6rafp3x3 203 20 fibroblast fibroblast NN cord-023865-6rafp3x3 203 21 - - HYPH cord-023865-6rafp3x3 203 22 myofibroblast myofibroblast NN cord-023865-6rafp3x3 203 23 transition transition NN cord-023865-6rafp3x3 203 24 . . . cord-023865-6rafp3x3 204 1 Hence hence RB cord-023865-6rafp3x3 204 2 , , , cord-023865-6rafp3x3 204 3 it -PRON- PRP cord-023865-6rafp3x3 204 4 is be VBZ cord-023865-6rafp3x3 204 5 worth worth JJ cord-023865-6rafp3x3 204 6 speculating speculate VBG cord-023865-6rafp3x3 204 7 that that IN cord-023865-6rafp3x3 204 8 some some DT cord-023865-6rafp3x3 204 9 of of IN cord-023865-6rafp3x3 204 10 the the DT cord-023865-6rafp3x3 204 11 SARS SARS NNP cord-023865-6rafp3x3 204 12 - - HYPH cord-023865-6rafp3x3 204 13 CoV CoV NNP cord-023865-6rafp3x3 204 14 encoded encode VBN cord-023865-6rafp3x3 204 15 factors factor NNS cord-023865-6rafp3x3 204 16 may may MD cord-023865-6rafp3x3 204 17 be be VB cord-023865-6rafp3x3 204 18 modulating modulate VBG cord-023865-6rafp3x3 204 19 the the DT cord-023865-6rafp3x3 204 20 TGFb TGFb NNPS cord-023865-6rafp3x3 204 21 signaling signal VBG cord-023865-6rafp3x3 204 22 pathway pathway NN cord-023865-6rafp3x3 204 23 . . . cord-023865-6rafp3x3 205 1 In in IN cord-023865-6rafp3x3 205 2 fact fact NN cord-023865-6rafp3x3 205 3 , , , cord-023865-6rafp3x3 205 4 proteins protein NNS cord-023865-6rafp3x3 205 5 of of IN cord-023865-6rafp3x3 205 6 several several JJ cord-023865-6rafp3x3 205 7 other other JJ cord-023865-6rafp3x3 205 8 viruses virus NNS cord-023865-6rafp3x3 205 9 , , , cord-023865-6rafp3x3 205 10 such such JJ cord-023865-6rafp3x3 205 11 as as IN cord-023865-6rafp3x3 205 12 hepatitis hepatitis NN cord-023865-6rafp3x3 205 13 C C NNP cord-023865-6rafp3x3 205 14 virus virus NN cord-023865-6rafp3x3 205 15 core core NN cord-023865-6rafp3x3 205 16 , , , cord-023865-6rafp3x3 205 17 NS3 ns3 RB cord-023865-6rafp3x3 205 18 and and CC cord-023865-6rafp3x3 205 19 NS5 ns5 JJ cord-023865-6rafp3x3 205 20 protein protein NN cord-023865-6rafp3x3 205 21 , , , cord-023865-6rafp3x3 205 22 adenovirus adenovirus NN cord-023865-6rafp3x3 205 23 E1A e1a NN cord-023865-6rafp3x3 205 24 , , , cord-023865-6rafp3x3 205 25 human human JJ cord-023865-6rafp3x3 205 26 papilloma papilloma NN cord-023865-6rafp3x3 205 27 virus virus NN cord-023865-6rafp3x3 205 28 E7 E7 NNP cord-023865-6rafp3x3 205 29 , , , cord-023865-6rafp3x3 205 30 human human JJ cord-023865-6rafp3x3 205 31 T T NNP cord-023865-6rafp3x3 205 32 - - HYPH cord-023865-6rafp3x3 205 33 lymphotropic lymphotropic NNP cord-023865-6rafp3x3 205 34 virus virus NN cord-023865-6rafp3x3 205 35 Tax Tax NNP cord-023865-6rafp3x3 205 36 and and CC cord-023865-6rafp3x3 205 37 Epstein Epstein NNP cord-023865-6rafp3x3 205 38 - - HYPH cord-023865-6rafp3x3 205 39 Barr Barr NNP cord-023865-6rafp3x3 205 40 virus virus NN cord-023865-6rafp3x3 205 41 LMP1 LMP1 NNP cord-023865-6rafp3x3 205 42 , , , cord-023865-6rafp3x3 205 43 have have VBP cord-023865-6rafp3x3 205 44 been be VBN cord-023865-6rafp3x3 205 45 reported report VBN cord-023865-6rafp3x3 205 46 to to TO cord-023865-6rafp3x3 205 47 modulate modulate VB cord-023865-6rafp3x3 205 48 the the DT cord-023865-6rafp3x3 205 49 TGFb TGFb NNP cord-023865-6rafp3x3 205 50 pathway pathway NN cord-023865-6rafp3x3 205 51 . . . cord-023865-6rafp3x3 206 1 In in IN cord-023865-6rafp3x3 206 2 general general JJ cord-023865-6rafp3x3 206 3 , , , cord-023865-6rafp3x3 206 4 these these DT cord-023865-6rafp3x3 206 5 proteins protein NNS cord-023865-6rafp3x3 206 6 directly directly RB cord-023865-6rafp3x3 206 7 bind bind VBP cord-023865-6rafp3x3 206 8 with with IN cord-023865-6rafp3x3 206 9 smad smad JJ cord-023865-6rafp3x3 206 10 proteins protein NNS cord-023865-6rafp3x3 206 11 and and CC cord-023865-6rafp3x3 206 12 alter alter VB cord-023865-6rafp3x3 206 13 the the DT cord-023865-6rafp3x3 206 14 innate innate JJ cord-023865-6rafp3x3 206 15 signaling signal VBG cord-023865-6rafp3x3 206 16 pathway pathway NN cord-023865-6rafp3x3 206 17 . . . cord-023865-6rafp3x3 207 1 Interestingly interestingly RB cord-023865-6rafp3x3 207 2 , , , cord-023865-6rafp3x3 207 3 a a DT cord-023865-6rafp3x3 207 4 recent recent JJ cord-023865-6rafp3x3 207 5 report report NN cord-023865-6rafp3x3 207 6 published publish VBN cord-023865-6rafp3x3 207 7 by by IN cord-023865-6rafp3x3 207 8 Zhao Zhao NNP cord-023865-6rafp3x3 207 9 et et NNP cord-023865-6rafp3x3 207 10 al al NNP cord-023865-6rafp3x3 207 11 . . . cord-023865-6rafp3x3 208 1 ( ( -LRB- cord-023865-6rafp3x3 208 2 2008 2008 CD cord-023865-6rafp3x3 208 3 ) ) -RRB- cord-023865-6rafp3x3 208 4 revealed reveal VBD cord-023865-6rafp3x3 208 5 that that IN cord-023865-6rafp3x3 208 6 N n NN cord-023865-6rafp3x3 208 7 - - HYPH cord-023865-6rafp3x3 208 8 protein protein NN cord-023865-6rafp3x3 208 9 of of IN cord-023865-6rafp3x3 208 10 SARS SARS NNP cord-023865-6rafp3x3 208 11 - - HYPH cord-023865-6rafp3x3 208 12 CoV CoV NNP cord-023865-6rafp3x3 208 13 also also RB cord-023865-6rafp3x3 208 14 interacts interact VBZ cord-023865-6rafp3x3 208 15 with with IN cord-023865-6rafp3x3 208 16 smad3 smad3 NN cord-023865-6rafp3x3 208 17 and and CC cord-023865-6rafp3x3 208 18 modulates modulate VBZ cord-023865-6rafp3x3 208 19 the the DT cord-023865-6rafp3x3 208 20 activity activity NN cord-023865-6rafp3x3 208 21 of of IN cord-023865-6rafp3x3 208 22 the the DT cord-023865-6rafp3x3 208 23 TGFb TGFb NNP cord-023865-6rafp3x3 208 24 pathway pathway NN cord-023865-6rafp3x3 208 25 . . . cord-023865-6rafp3x3 209 1 By by IN cord-023865-6rafp3x3 209 2 performing perform VBG cord-023865-6rafp3x3 209 3 a a DT cord-023865-6rafp3x3 209 4 smad smad JJ cord-023865-6rafp3x3 209 5 binding bind VBG cord-023865-6rafp3x3 209 6 element element NN cord-023865-6rafp3x3 209 7 ( ( -LRB- cord-023865-6rafp3x3 209 8 SBE)-driven SBE)-driven NNP cord-023865-6rafp3x3 209 9 reporter reporter NN cord-023865-6rafp3x3 209 10 assay assay NN cord-023865-6rafp3x3 209 11 , , , cord-023865-6rafp3x3 209 12 RT RT NNP cord-023865-6rafp3x3 209 13 - - HYPH cord-023865-6rafp3x3 209 14 PCR PCR NNP cord-023865-6rafp3x3 209 15 and and CC cord-023865-6rafp3x3 209 16 immunohistological immunohistological NNP cord-023865-6rafp3x3 209 17 analysis analysis NN cord-023865-6rafp3x3 209 18 of of IN cord-023865-6rafp3x3 209 19 TGFb TGFb NNP cord-023865-6rafp3x3 209 20 target target NN cord-023865-6rafp3x3 209 21 genes gene NNS cord-023865-6rafp3x3 209 22 such such JJ cord-023865-6rafp3x3 209 23 as as IN cord-023865-6rafp3x3 209 24 PAI-1 PAI-1 NNP cord-023865-6rafp3x3 209 25 ( ( -LRB- cord-023865-6rafp3x3 209 26 plasminogen plasminogen NN cord-023865-6rafp3x3 209 27 activator activator NN cord-023865-6rafp3x3 209 28 inhibitor inhibitor NN cord-023865-6rafp3x3 209 29 1 1 CD cord-023865-6rafp3x3 209 30 ) ) -RRB- cord-023865-6rafp3x3 209 31 and and CC cord-023865-6rafp3x3 209 32 collagen collagen NN cord-023865-6rafp3x3 209 33 in in IN cord-023865-6rafp3x3 209 34 a a DT cord-023865-6rafp3x3 209 35 variety variety NN cord-023865-6rafp3x3 209 36 of of IN cord-023865-6rafp3x3 209 37 cell cell NN cord-023865-6rafp3x3 209 38 lines line NNS cord-023865-6rafp3x3 209 39 and and CC cord-023865-6rafp3x3 209 40 SARS SARS NNP cord-023865-6rafp3x3 209 41 patients patient NNS cord-023865-6rafp3x3 209 42 , , , cord-023865-6rafp3x3 209 43 the the DT cord-023865-6rafp3x3 209 44 authors author NNS cord-023865-6rafp3x3 209 45 have have VBP cord-023865-6rafp3x3 209 46 clearly clearly RB cord-023865-6rafp3x3 209 47 proved prove VBN cord-023865-6rafp3x3 209 48 that that IN cord-023865-6rafp3x3 209 49 N n NN cord-023865-6rafp3x3 209 50 - - HYPH cord-023865-6rafp3x3 209 51 protein protein NN cord-023865-6rafp3x3 209 52 indeed indeed RB cord-023865-6rafp3x3 209 53 enhanced enhance VBD cord-023865-6rafp3x3 209 54 the the DT cord-023865-6rafp3x3 209 55 activity activity NN cord-023865-6rafp3x3 209 56 of of IN cord-023865-6rafp3x3 209 57 the the DT cord-023865-6rafp3x3 209 58 TGFb TGFb NNPS cord-023865-6rafp3x3 209 59 signaling signal VBG cord-023865-6rafp3x3 209 60 pathway pathway NN cord-023865-6rafp3x3 209 61 . . . cord-023865-6rafp3x3 210 1 Further further RB cord-023865-6rafp3x3 210 2 , , , cord-023865-6rafp3x3 210 3 they -PRON- PRP cord-023865-6rafp3x3 210 4 observed observe VBD cord-023865-6rafp3x3 210 5 that that IN cord-023865-6rafp3x3 210 6 the the DT cord-023865-6rafp3x3 210 7 effect effect NN cord-023865-6rafp3x3 210 8 of of IN cord-023865-6rafp3x3 210 9 N n NN cord-023865-6rafp3x3 210 10 - - HYPH cord-023865-6rafp3x3 210 11 protein protein NN cord-023865-6rafp3x3 210 12 on on IN cord-023865-6rafp3x3 210 13 TGFb TGFb NNPS cord-023865-6rafp3x3 210 14 signaling signaling NN cord-023865-6rafp3x3 210 15 was be VBD cord-023865-6rafp3x3 210 16 mediated mediate VBN cord-023865-6rafp3x3 210 17 through through IN cord-023865-6rafp3x3 210 18 smad3 smad3 NN cord-023865-6rafp3x3 210 19 only only RB cord-023865-6rafp3x3 210 20 ( ( -LRB- cord-023865-6rafp3x3 210 21 independent independent JJ cord-023865-6rafp3x3 210 22 of of IN cord-023865-6rafp3x3 210 23 the the DT cord-023865-6rafp3x3 210 24 involvement involvement NN cord-023865-6rafp3x3 210 25 of of IN cord-023865-6rafp3x3 210 26 smad4 smad4 NN cord-023865-6rafp3x3 210 27 ) ) -RRB- cord-023865-6rafp3x3 210 28 . . . cord-023865-6rafp3x3 211 1 While while IN cord-023865-6rafp3x3 211 2 trying try VBG cord-023865-6rafp3x3 211 3 to to TO cord-023865-6rafp3x3 211 4 unravel unravel VB cord-023865-6rafp3x3 211 5 the the DT cord-023865-6rafp3x3 211 6 mechanism mechanism NN cord-023865-6rafp3x3 211 7 behind behind IN cord-023865-6rafp3x3 211 8 this this DT cord-023865-6rafp3x3 211 9 phenomenon phenomenon NN cord-023865-6rafp3x3 211 10 , , , cord-023865-6rafp3x3 211 11 they -PRON- PRP cord-023865-6rafp3x3 211 12 observed observe VBD cord-023865-6rafp3x3 211 13 that that IN cord-023865-6rafp3x3 211 14 N n NN cord-023865-6rafp3x3 211 15 - - HYPH cord-023865-6rafp3x3 211 16 protein protein NN cord-023865-6rafp3x3 211 17 specifically specifically RB cord-023865-6rafp3x3 211 18 associated associate VBN cord-023865-6rafp3x3 211 19 with with IN cord-023865-6rafp3x3 211 20 the the DT cord-023865-6rafp3x3 211 21 MH2 MH2 NNP cord-023865-6rafp3x3 211 22 domain domain NN cord-023865-6rafp3x3 211 23 of of IN cord-023865-6rafp3x3 211 24 smad3 smad3 NN cord-023865-6rafp3x3 211 25 ( ( -LRB- cord-023865-6rafp3x3 211 26 stronger strong JJR cord-023865-6rafp3x3 211 27 binding bind VBG cord-023865-6rafp3x3 211 28 affinity affinity NN cord-023865-6rafp3x3 211 29 for for IN cord-023865-6rafp3x3 211 30 phospho phospho NNP cord-023865-6rafp3x3 211 31 smad3 smad3 NNP cord-023865-6rafp3x3 211 32 ) ) -RRB- cord-023865-6rafp3x3 211 33 interrupted interrupt VBD cord-023865-6rafp3x3 211 34 the the DT cord-023865-6rafp3x3 211 35 interaction interaction NN cord-023865-6rafp3x3 211 36 between between IN cord-023865-6rafp3x3 211 37 smad3 smad3 NN cord-023865-6rafp3x3 211 38 and and CC cord-023865-6rafp3x3 211 39 smad4 smad4 NN cord-023865-6rafp3x3 211 40 , , , cord-023865-6rafp3x3 211 41 and and CC cord-023865-6rafp3x3 211 42 enhanced enhance VBD cord-023865-6rafp3x3 211 43 the the DT cord-023865-6rafp3x3 211 44 interaction interaction NN cord-023865-6rafp3x3 211 45 between between IN cord-023865-6rafp3x3 211 46 smad3 smad3 NNP cord-023865-6rafp3x3 211 47 and and CC cord-023865-6rafp3x3 211 48 transcriptional transcriptional JJ cord-023865-6rafp3x3 211 49 coactivator coactivator NNP cord-023865-6rafp3x3 211 50 p300 p300 NNP cord-023865-6rafp3x3 211 51 in in IN cord-023865-6rafp3x3 211 52 a a DT cord-023865-6rafp3x3 211 53 dose dose NN cord-023865-6rafp3x3 211 54 - - HYPH cord-023865-6rafp3x3 211 55 dependent dependent JJ cord-023865-6rafp3x3 211 56 manner manner NN cord-023865-6rafp3x3 211 57 . . . cord-023865-6rafp3x3 212 1 To to TO cord-023865-6rafp3x3 212 2 further further RB cord-023865-6rafp3x3 212 3 confirm confirm VB cord-023865-6rafp3x3 212 4 the the DT cord-023865-6rafp3x3 212 5 above above JJ cord-023865-6rafp3x3 212 6 data datum NNS cord-023865-6rafp3x3 212 7 , , , cord-023865-6rafp3x3 212 8 they -PRON- PRP cord-023865-6rafp3x3 212 9 performed perform VBD cord-023865-6rafp3x3 212 10 a a DT cord-023865-6rafp3x3 212 11 chromatin chromatin NN cord-023865-6rafp3x3 212 12 immunoprecipitation immunoprecipitation NN cord-023865-6rafp3x3 212 13 assay assay NN cord-023865-6rafp3x3 212 14 at at IN cord-023865-6rafp3x3 212 15 the the DT cord-023865-6rafp3x3 212 16 SBE SBE NNP cord-023865-6rafp3x3 212 17 region region NN cord-023865-6rafp3x3 212 18 of of IN cord-023865-6rafp3x3 212 19 PAI-1 PAI-1 NNP cord-023865-6rafp3x3 212 20 promoter promoter NN cord-023865-6rafp3x3 212 21 in in IN cord-023865-6rafp3x3 212 22 HPL1 HPL1 NNP cord-023865-6rafp3x3 212 23 cells cell NNS cord-023865-6rafp3x3 212 24 and and CC cord-023865-6rafp3x3 212 25 detected detect VBD cord-023865-6rafp3x3 212 26 the the DT cord-023865-6rafp3x3 212 27 presence presence NN cord-023865-6rafp3x3 212 28 of of IN cord-023865-6rafp3x3 212 29 N n NN cord-023865-6rafp3x3 212 30 - - HYPH cord-023865-6rafp3x3 212 31 protein protein NN cord-023865-6rafp3x3 212 32 in in IN cord-023865-6rafp3x3 212 33 the the DT cord-023865-6rafp3x3 212 34 complex complex NN cord-023865-6rafp3x3 212 35 of of IN cord-023865-6rafp3x3 212 36 smad3 smad3 NNP cord-023865-6rafp3x3 212 37 and and CC cord-023865-6rafp3x3 212 38 p300 p300 NNP cord-023865-6rafp3x3 212 39 . . . cord-023865-6rafp3x3 213 1 Interestingly interestingly RB cord-023865-6rafp3x3 213 2 , , , cord-023865-6rafp3x3 213 3 however however RB cord-023865-6rafp3x3 213 4 , , , cord-023865-6rafp3x3 213 5 N n CD cord-023865-6rafp3x3 213 6 - - HYPH cord-023865-6rafp3x3 213 7 protein protein NN cord-023865-6rafp3x3 213 8 inhibited inhibited JJ cord-023865-6rafp3x3 213 9 TGFb TGFb NNPS cord-023865-6rafp3x3 213 10 - - HYPH cord-023865-6rafp3x3 213 11 induced induce VBN cord-023865-6rafp3x3 213 12 apoptosis apoptosis NN cord-023865-6rafp3x3 213 13 of of IN cord-023865-6rafp3x3 213 14 HPL1 HPL1 NNP cord-023865-6rafp3x3 213 15 cells cell NNS cord-023865-6rafp3x3 213 16 ( ( -LRB- cord-023865-6rafp3x3 213 17 it -PRON- PRP cord-023865-6rafp3x3 213 18 is be VBZ cord-023865-6rafp3x3 213 19 a a DT cord-023865-6rafp3x3 213 20 well well RB cord-023865-6rafp3x3 213 21 established establish VBN cord-023865-6rafp3x3 213 22 fact fact NN cord-023865-6rafp3x3 213 23 that that IN cord-023865-6rafp3x3 213 24 smad3 smad3 NNP cord-023865-6rafp3x3 213 25 activation activation NN cord-023865-6rafp3x3 213 26 induces induce VBZ cord-023865-6rafp3x3 213 27 apoptosis apoptosis NN cord-023865-6rafp3x3 213 28 of of IN cord-023865-6rafp3x3 213 29 HPL1 HPL1 NNP cord-023865-6rafp3x3 213 30 cells cell NNS cord-023865-6rafp3x3 213 31 ) ) -RRB- cord-023865-6rafp3x3 213 32 . . . cord-023865-6rafp3x3 214 1 Thus thus RB cord-023865-6rafp3x3 214 2 , , , cord-023865-6rafp3x3 214 3 N n CD cord-023865-6rafp3x3 214 4 - - HYPH cord-023865-6rafp3x3 214 5 protein protein NN cord-023865-6rafp3x3 214 6 appears appear VBZ cord-023865-6rafp3x3 214 7 to to TO cord-023865-6rafp3x3 214 8 employ employ VB cord-023865-6rafp3x3 214 9 a a DT cord-023865-6rafp3x3 214 10 clever clever JJ cord-023865-6rafp3x3 214 11 mechanism mechanism NN cord-023865-6rafp3x3 214 12 whereby whereby WRB cord-023865-6rafp3x3 214 13 , , , cord-023865-6rafp3x3 214 14 on on IN cord-023865-6rafp3x3 214 15 the the DT cord-023865-6rafp3x3 214 16 one one CD cord-023865-6rafp3x3 214 17 hand hand NN cord-023865-6rafp3x3 214 18 , , , cord-023865-6rafp3x3 214 19 it -PRON- PRP cord-023865-6rafp3x3 214 20 enhances enhance VBZ cord-023865-6rafp3x3 214 21 the the DT cord-023865-6rafp3x3 214 22 activity activity NN cord-023865-6rafp3x3 214 23 of of IN cord-023865-6rafp3x3 214 24 the the DT cord-023865-6rafp3x3 214 25 TGFb TGFb NNPS cord-023865-6rafp3x3 214 26 signaling signal VBG cord-023865-6rafp3x3 214 27 pathway pathway NN cord-023865-6rafp3x3 214 28 , , , cord-023865-6rafp3x3 214 29 thus thus RB cord-023865-6rafp3x3 214 30 leading lead VBG cord-023865-6rafp3x3 214 31 to to IN cord-023865-6rafp3x3 214 32 enhanced enhanced JJ cord-023865-6rafp3x3 214 33 expression expression NN cord-023865-6rafp3x3 214 34 of of IN cord-023865-6rafp3x3 214 35 a a DT cord-023865-6rafp3x3 214 36 subset subset NN cord-023865-6rafp3x3 214 37 of of IN cord-023865-6rafp3x3 214 38 genes gene NNS cord-023865-6rafp3x3 214 39 ( ( -LRB- cord-023865-6rafp3x3 214 40 such such JJ cord-023865-6rafp3x3 214 41 as as IN cord-023865-6rafp3x3 214 42 ECM ECM NNP cord-023865-6rafp3x3 214 43 protein protein NN cord-023865-6rafp3x3 214 44 coding coding NN cord-023865-6rafp3x3 214 45 genes gene NNS cord-023865-6rafp3x3 214 46 ) ) -RRB- cord-023865-6rafp3x3 214 47 , , , cord-023865-6rafp3x3 214 48 and and CC cord-023865-6rafp3x3 214 49 on on IN cord-023865-6rafp3x3 214 50 the the DT cord-023865-6rafp3x3 214 51 other other JJ cord-023865-6rafp3x3 214 52 hand hand NN cord-023865-6rafp3x3 214 53 , , , cord-023865-6rafp3x3 214 54 it -PRON- PRP cord-023865-6rafp3x3 214 55 blocks block VBZ cord-023865-6rafp3x3 214 56 the the DT cord-023865-6rafp3x3 214 57 programmed programmed JJ cord-023865-6rafp3x3 214 58 cell cell NN cord-023865-6rafp3x3 214 59 death death NN cord-023865-6rafp3x3 214 60 of of IN cord-023865-6rafp3x3 214 61 the the DT cord-023865-6rafp3x3 214 62 host host NN cord-023865-6rafp3x3 214 63 cell cell NN cord-023865-6rafp3x3 214 64 . . . cord-023865-6rafp3x3 215 1 It -PRON- PRP cord-023865-6rafp3x3 215 2 would would MD cord-023865-6rafp3x3 215 3 be be VB cord-023865-6rafp3x3 215 4 interesting interesting JJ cord-023865-6rafp3x3 215 5 to to TO cord-023865-6rafp3x3 215 6 unravel unravel VB cord-023865-6rafp3x3 215 7 the the DT cord-023865-6rafp3x3 215 8 mechanism mechanism NN cord-023865-6rafp3x3 215 9 behind behind IN cord-023865-6rafp3x3 215 10 this this DT cord-023865-6rafp3x3 215 11 unique unique JJ cord-023865-6rafp3x3 215 12 property property NN cord-023865-6rafp3x3 215 13 of of IN cord-023865-6rafp3x3 215 14 the the DT cord-023865-6rafp3x3 215 15 N N NNP cord-023865-6rafp3x3 215 16 - - HYPH cord-023865-6rafp3x3 215 17 protein protein NN cord-023865-6rafp3x3 215 18 . . . cord-023865-6rafp3x3 216 1 Another another DT cord-023865-6rafp3x3 216 2 major major JJ cord-023865-6rafp3x3 216 3 proinflammatory proinflammatory JJ cord-023865-6rafp3x3 216 4 factor factor NN cord-023865-6rafp3x3 216 5 induced induce VBN cord-023865-6rafp3x3 216 6 during during IN cord-023865-6rafp3x3 216 7 viral viral JJ cord-023865-6rafp3x3 216 8 infection infection NN cord-023865-6rafp3x3 216 9 is be VBZ cord-023865-6rafp3x3 216 10 the the DT cord-023865-6rafp3x3 216 11 cyclooxygenase-2 cyclooxygenase-2 NNP cord-023865-6rafp3x3 216 12 ( ( -LRB- cord-023865-6rafp3x3 216 13 COX2 COX2 NNP cord-023865-6rafp3x3 216 14 ) ) -RRB- cord-023865-6rafp3x3 216 15 protein protein NN cord-023865-6rafp3x3 216 16 . . . cord-023865-6rafp3x3 217 1 Using use VBG cord-023865-6rafp3x3 217 2 293 293 CD cord-023865-6rafp3x3 217 3 T T NNP cord-023865-6rafp3x3 217 4 cells cell NNS cord-023865-6rafp3x3 217 5 expressing express VBG cord-023865-6rafp3x3 217 6 the the DT cord-023865-6rafp3x3 217 7 N n CD cord-023865-6rafp3x3 217 8 - - HYPH cord-023865-6rafp3x3 217 9 protein protein NN cord-023865-6rafp3x3 217 10 , , , cord-023865-6rafp3x3 217 11 Yan Yan NNP cord-023865-6rafp3x3 217 12 et et NNP cord-023865-6rafp3x3 217 13 al al NNP cord-023865-6rafp3x3 217 14 . . . cord-023865-6rafp3x3 218 1 ( ( -LRB- cord-023865-6rafp3x3 218 2 2006 2006 CD cord-023865-6rafp3x3 218 3 ) ) -RRB- cord-023865-6rafp3x3 218 4 have have VBP cord-023865-6rafp3x3 218 5 shown show VBN cord-023865-6rafp3x3 218 6 that that DT cord-023865-6rafp3x3 218 7 expression expression NN cord-023865-6rafp3x3 218 8 of of IN cord-023865-6rafp3x3 218 9 the the DT cord-023865-6rafp3x3 218 10 N n CD cord-023865-6rafp3x3 218 11 - - HYPH cord-023865-6rafp3x3 218 12 protein protein NN cord-023865-6rafp3x3 218 13 leads lead VBZ cord-023865-6rafp3x3 218 14 to to IN cord-023865-6rafp3x3 218 15 upregulation upregulation NN cord-023865-6rafp3x3 218 16 of of IN cord-023865-6rafp3x3 218 17 COX2 cox2 JJ cord-023865-6rafp3x3 218 18 protein protein NN cord-023865-6rafp3x3 218 19 production production NN cord-023865-6rafp3x3 218 20 in in IN cord-023865-6rafp3x3 218 21 a a DT cord-023865-6rafp3x3 218 22 transcriptional transcriptional JJ cord-023865-6rafp3x3 218 23 manner manner NN cord-023865-6rafp3x3 218 24 . . . cord-023865-6rafp3x3 219 1 They -PRON- PRP cord-023865-6rafp3x3 219 2 have have VBP cord-023865-6rafp3x3 219 3 further further RB cord-023865-6rafp3x3 219 4 demonstrated demonstrate VBN cord-023865-6rafp3x3 219 5 that that IN cord-023865-6rafp3x3 219 6 the the DT cord-023865-6rafp3x3 219 7 N n NN cord-023865-6rafp3x3 219 8 - - HYPH cord-023865-6rafp3x3 219 9 protein protein NN cord-023865-6rafp3x3 219 10 directly directly RB cord-023865-6rafp3x3 219 11 binds bind VBZ cord-023865-6rafp3x3 219 12 to to IN cord-023865-6rafp3x3 219 13 the the DT cord-023865-6rafp3x3 219 14 NFkB NFkB NNP cord-023865-6rafp3x3 219 15 response response NN cord-023865-6rafp3x3 219 16 element element NN cord-023865-6rafp3x3 219 17 present present JJ cord-023865-6rafp3x3 219 18 in in IN cord-023865-6rafp3x3 219 19 the the DT cord-023865-6rafp3x3 219 20 COX2 cox2 JJ cord-023865-6rafp3x3 219 21 promoter promoter NN cord-023865-6rafp3x3 219 22 through through IN cord-023865-6rafp3x3 219 23 a a DT cord-023865-6rafp3x3 219 24 68 68 CD cord-023865-6rafp3x3 219 25 aa aa NNP cord-023865-6rafp3x3 219 26 residue residue NN cord-023865-6rafp3x3 219 27 binding binding NN cord-023865-6rafp3x3 219 28 domain domain NN cord-023865-6rafp3x3 219 29 ( ( -LRB- cord-023865-6rafp3x3 219 30 aa aa NNP cord-023865-6rafp3x3 219 31 136 136 CD cord-023865-6rafp3x3 219 32 - - HYPH cord-023865-6rafp3x3 219 33 204 204 CD cord-023865-6rafp3x3 219 34 ) ) -RRB- cord-023865-6rafp3x3 219 35 and and CC cord-023865-6rafp3x3 219 36 activates activate VBZ cord-023865-6rafp3x3 219 37 its -PRON- PRP$ cord-023865-6rafp3x3 219 38 transcription transcription NN cord-023865-6rafp3x3 219 39 . . . cord-023865-6rafp3x3 220 1 Although although IN cord-023865-6rafp3x3 220 2 the the DT cord-023865-6rafp3x3 220 3 N n NN cord-023865-6rafp3x3 220 4 - - HYPH cord-023865-6rafp3x3 220 5 protein protein NN cord-023865-6rafp3x3 220 6 is be VBZ cord-023865-6rafp3x3 220 7 known know VBN cord-023865-6rafp3x3 220 8 to to TO cord-023865-6rafp3x3 220 9 associate associate VB cord-023865-6rafp3x3 220 10 with with IN cord-023865-6rafp3x3 220 11 stretches stretch NNS cord-023865-6rafp3x3 220 12 of of IN cord-023865-6rafp3x3 220 13 nucleic nucleic JJ cord-023865-6rafp3x3 220 14 acids acid NNS cord-023865-6rafp3x3 220 15 , , , cord-023865-6rafp3x3 220 16 to to IN cord-023865-6rafp3x3 220 17 date date NN cord-023865-6rafp3x3 220 18 there there EX cord-023865-6rafp3x3 220 19 is be VBZ cord-023865-6rafp3x3 220 20 no no DT cord-023865-6rafp3x3 220 21 other other JJ cord-023865-6rafp3x3 220 22 documentation documentation NN cord-023865-6rafp3x3 220 23 or or CC cord-023865-6rafp3x3 220 24 prediction prediction NN cord-023865-6rafp3x3 220 25 of of IN cord-023865-6rafp3x3 220 26 its -PRON- PRP$ cord-023865-6rafp3x3 220 27 sequence sequence NN cord-023865-6rafp3x3 220 28 - - HYPH cord-023865-6rafp3x3 220 29 specific specific JJ cord-023865-6rafp3x3 220 30 DNA dna NN cord-023865-6rafp3x3 220 31 binding binding NN cord-023865-6rafp3x3 220 32 activity activity NN cord-023865-6rafp3x3 220 33 ( ( -LRB- cord-023865-6rafp3x3 220 34 as as IN cord-023865-6rafp3x3 220 35 a a DT cord-023865-6rafp3x3 220 36 transcription transcription NN cord-023865-6rafp3x3 220 37 factor factor NN cord-023865-6rafp3x3 220 38 ) ) -RRB- cord-023865-6rafp3x3 220 39 . . . cord-023865-6rafp3x3 221 1 In in IN cord-023865-6rafp3x3 221 2 such such PDT cord-023865-6rafp3x3 221 3 a a DT cord-023865-6rafp3x3 221 4 scenario scenario NN cord-023865-6rafp3x3 221 5 , , , cord-023865-6rafp3x3 221 6 the the DT cord-023865-6rafp3x3 221 7 above above JJ cord-023865-6rafp3x3 221 8 observation observation NN cord-023865-6rafp3x3 221 9 , , , cord-023865-6rafp3x3 221 10 if if IN cord-023865-6rafp3x3 221 11 reproducible reproducible JJ cord-023865-6rafp3x3 221 12 in in IN cord-023865-6rafp3x3 221 13 vivo vivo NN cord-023865-6rafp3x3 221 14 , , , cord-023865-6rafp3x3 221 15 may may MD cord-023865-6rafp3x3 221 16 really really RB cord-023865-6rafp3x3 221 17 be be VB cord-023865-6rafp3x3 221 18 a a DT cord-023865-6rafp3x3 221 19 unique unique JJ cord-023865-6rafp3x3 221 20 property property NN cord-023865-6rafp3x3 221 21 of of IN cord-023865-6rafp3x3 221 22 the the DT cord-023865-6rafp3x3 221 23 N N NNP cord-023865-6rafp3x3 221 24 - - HYPH cord-023865-6rafp3x3 221 25 protein protein NN cord-023865-6rafp3x3 221 26 and and CC cord-023865-6rafp3x3 221 27 may may MD cord-023865-6rafp3x3 221 28 further further RB cord-023865-6rafp3x3 221 29 add add VB cord-023865-6rafp3x3 221 30 to to IN cord-023865-6rafp3x3 221 31 the the DT cord-023865-6rafp3x3 221 32 established establish VBN cord-023865-6rafp3x3 221 33 regulatory regulatory JJ cord-023865-6rafp3x3 221 34 functions function NNS cord-023865-6rafp3x3 221 35 of of IN cord-023865-6rafp3x3 221 36 the the DT cord-023865-6rafp3x3 221 37 N n NN cord-023865-6rafp3x3 221 38 - - HYPH cord-023865-6rafp3x3 221 39 protein protein NN cord-023865-6rafp3x3 221 40 . . . cord-023865-6rafp3x3 222 1 Exogenously Exogenously NNP cord-023865-6rafp3x3 222 2 expressed express VBD cord-023865-6rafp3x3 222 3 N n CD cord-023865-6rafp3x3 222 4 - - HYPH cord-023865-6rafp3x3 222 5 protein protein NN cord-023865-6rafp3x3 222 6 has have VBZ cord-023865-6rafp3x3 222 7 been be VBN cord-023865-6rafp3x3 222 8 reported report VBN cord-023865-6rafp3x3 222 9 to to TO cord-023865-6rafp3x3 222 10 enhance enhance VB cord-023865-6rafp3x3 222 11 the the DT cord-023865-6rafp3x3 222 12 DNA dna NN cord-023865-6rafp3x3 222 13 binding binding NN cord-023865-6rafp3x3 222 14 activity activity NN cord-023865-6rafp3x3 222 15 of of IN cord-023865-6rafp3x3 222 16 c c NN cord-023865-6rafp3x3 222 17 - - HYPH cord-023865-6rafp3x3 222 18 fos fos NNP cord-023865-6rafp3x3 222 19 , , , cord-023865-6rafp3x3 222 20 ATF-2 ATF-2 NNP cord-023865-6rafp3x3 222 21 , , , cord-023865-6rafp3x3 222 22 CREB-1 CREB-1 NNP cord-023865-6rafp3x3 222 23 , , , cord-023865-6rafp3x3 222 24 and and CC cord-023865-6rafp3x3 222 25 fos fos NNP cord-023865-6rafp3x3 222 26 B B NNP cord-023865-6rafp3x3 222 27 in in IN cord-023865-6rafp3x3 222 28 an an DT cord-023865-6rafp3x3 222 29 ELISA ELISA NNP cord-023865-6rafp3x3 222 30 - - HYPH cord-023865-6rafp3x3 222 31 based base VBN cord-023865-6rafp3x3 222 32 assay assay NN cord-023865-6rafp3x3 222 33 , , , cord-023865-6rafp3x3 222 34 thus thus RB cord-023865-6rafp3x3 222 35 suggesting suggest VBG cord-023865-6rafp3x3 222 36 an an DT cord-023865-6rafp3x3 222 37 increase increase NN cord-023865-6rafp3x3 222 38 in in IN cord-023865-6rafp3x3 222 39 AP1 ap1 NN cord-023865-6rafp3x3 222 40 activity activity NN cord-023865-6rafp3x3 222 41 in in IN cord-023865-6rafp3x3 222 42 these these DT cord-023865-6rafp3x3 222 43 cells cell NNS cord-023865-6rafp3x3 222 44 ( ( -LRB- cord-023865-6rafp3x3 222 45 He -PRON- PRP cord-023865-6rafp3x3 222 46 et et FW cord-023865-6rafp3x3 222 47 al al NNP cord-023865-6rafp3x3 222 48 . . NNP cord-023865-6rafp3x3 222 49 2003 2003 CD cord-023865-6rafp3x3 222 50 ) ) -RRB- cord-023865-6rafp3x3 222 51 . . . cord-023865-6rafp3x3 223 1 The the DT cord-023865-6rafp3x3 223 2 mechanistic mechanistic JJ cord-023865-6rafp3x3 223 3 details detail NNS cord-023865-6rafp3x3 223 4 and and CC cord-023865-6rafp3x3 223 5 functional functional JJ cord-023865-6rafp3x3 223 6 significance significance NN cord-023865-6rafp3x3 223 7 of of IN cord-023865-6rafp3x3 223 8 this this DT cord-023865-6rafp3x3 223 9 phenomenon phenomenon NN cord-023865-6rafp3x3 223 10 remain remain VBP cord-023865-6rafp3x3 223 11 to to TO cord-023865-6rafp3x3 223 12 be be VB cord-023865-6rafp3x3 223 13 elucidated elucidate VBN cord-023865-6rafp3x3 223 14 . . . cord-023865-6rafp3x3 224 1 Earlier early JJR cord-023865-6rafp3x3 224 2 work work NN cord-023865-6rafp3x3 224 3 done do VBN cord-023865-6rafp3x3 224 4 in in IN cord-023865-6rafp3x3 224 5 our -PRON- PRP$ cord-023865-6rafp3x3 224 6 laboratory laboratory NN cord-023865-6rafp3x3 224 7 has have VBZ cord-023865-6rafp3x3 224 8 shown show VBN cord-023865-6rafp3x3 224 9 that that IN cord-023865-6rafp3x3 224 10 N n NN cord-023865-6rafp3x3 224 11 - - HYPH cord-023865-6rafp3x3 224 12 protein protein NN cord-023865-6rafp3x3 224 13 , , , cord-023865-6rafp3x3 224 14 when when WRB cord-023865-6rafp3x3 224 15 expressed express VBN cord-023865-6rafp3x3 224 16 in in IN cord-023865-6rafp3x3 224 17 Cos-1 Cos-1 NNP cord-023865-6rafp3x3 224 18 monkey monkey NN cord-023865-6rafp3x3 224 19 kidney kidney NN cord-023865-6rafp3x3 224 20 cells cell NNS cord-023865-6rafp3x3 224 21 , , , cord-023865-6rafp3x3 224 22 induces induce VBZ cord-023865-6rafp3x3 224 23 apoptosis apoptosis NN cord-023865-6rafp3x3 224 24 in in IN cord-023865-6rafp3x3 224 25 the the DT cord-023865-6rafp3x3 224 26 absence absence NN cord-023865-6rafp3x3 224 27 of of IN cord-023865-6rafp3x3 224 28 growth growth NN cord-023865-6rafp3x3 224 29 factors factor NNS cord-023865-6rafp3x3 224 30 . . . cord-023865-6rafp3x3 225 1 Attempts attempt NNS cord-023865-6rafp3x3 225 2 to to TO cord-023865-6rafp3x3 225 3 understand understand VB cord-023865-6rafp3x3 225 4 the the DT cord-023865-6rafp3x3 225 5 mechanism mechanism NN cord-023865-6rafp3x3 225 6 of of IN cord-023865-6rafp3x3 225 7 programmed programmed JJ cord-023865-6rafp3x3 225 8 cell cell NN cord-023865-6rafp3x3 225 9 death death NN cord-023865-6rafp3x3 225 10 revealed reveal VBD cord-023865-6rafp3x3 225 11 that that IN cord-023865-6rafp3x3 225 12 the the DT cord-023865-6rafp3x3 225 13 N N NNP cord-023865-6rafp3x3 225 14 - - HYPH cord-023865-6rafp3x3 225 15 protein protein NN cord-023865-6rafp3x3 225 16 downmodulated downmodulate VBD cord-023865-6rafp3x3 225 17 the the DT cord-023865-6rafp3x3 225 18 activity activity NN cord-023865-6rafp3x3 225 19 of of IN cord-023865-6rafp3x3 225 20 prosurvival prosurvival NN cord-023865-6rafp3x3 225 21 factors factor NNS cord-023865-6rafp3x3 225 22 such such JJ cord-023865-6rafp3x3 225 23 as as IN cord-023865-6rafp3x3 225 24 extracellular extracellular JJ cord-023865-6rafp3x3 225 25 regulated regulated JJ cord-023865-6rafp3x3 225 26 kinase kinase NN cord-023865-6rafp3x3 225 27 , , , cord-023865-6rafp3x3 225 28 Akt Akt NNP cord-023865-6rafp3x3 225 29 and and CC cord-023865-6rafp3x3 225 30 bcl bcl NNP cord-023865-6rafp3x3 225 31 2 2 CD cord-023865-6rafp3x3 225 32 , , , cord-023865-6rafp3x3 225 33 and and CC cord-023865-6rafp3x3 225 34 upregulated upregulate VBD cord-023865-6rafp3x3 225 35 the the DT cord-023865-6rafp3x3 225 36 activity activity NN cord-023865-6rafp3x3 225 37 of of IN cord-023865-6rafp3x3 225 38 proapoptotic proapoptotic JJ cord-023865-6rafp3x3 225 39 factors factor NNS cord-023865-6rafp3x3 225 40 like like IN cord-023865-6rafp3x3 225 41 caspase-3 caspase-3 NNP cord-023865-6rafp3x3 225 42 and and CC cord-023865-6rafp3x3 225 43 caspase-7 caspase-7 NNP cord-023865-6rafp3x3 226 1 ( ( -LRB- cord-023865-6rafp3x3 226 2 Surjit Surjit NNP cord-023865-6rafp3x3 226 3 et et NNP cord-023865-6rafp3x3 226 4 al al NNP cord-023865-6rafp3x3 226 5 . . NNP cord-023865-6rafp3x3 226 6 2004b 2004b CD cord-023865-6rafp3x3 226 7 ) ) -RRB- cord-023865-6rafp3x3 226 8 . . . cord-023865-6rafp3x3 227 1 However however RB cord-023865-6rafp3x3 227 2 , , , cord-023865-6rafp3x3 227 3 this this DT cord-023865-6rafp3x3 227 4 phenomenon phenomenon NN cord-023865-6rafp3x3 227 5 was be VBD cord-023865-6rafp3x3 227 6 not not RB cord-023865-6rafp3x3 227 7 observed observe VBN cord-023865-6rafp3x3 227 8 in in IN cord-023865-6rafp3x3 227 9 another another DT cord-023865-6rafp3x3 227 10 cell cell NN cord-023865-6rafp3x3 227 11 line line NN cord-023865-6rafp3x3 227 12 of of IN cord-023865-6rafp3x3 227 13 epithelial epithelial JJ cord-023865-6rafp3x3 227 14 lineage lineage NN cord-023865-6rafp3x3 227 15 ( ( -LRB- cord-023865-6rafp3x3 227 16 huh7 huh7 NN cord-023865-6rafp3x3 227 17 ) ) -RRB- cord-023865-6rafp3x3 227 18 . . . cord-023865-6rafp3x3 228 1 The the DT cord-023865-6rafp3x3 228 2 above above JJ cord-023865-6rafp3x3 228 3 observation observation NN cord-023865-6rafp3x3 228 4 was be VBD cord-023865-6rafp3x3 228 5 further further RB cord-023865-6rafp3x3 228 6 confirmed confirm VBN cord-023865-6rafp3x3 228 7 by by IN cord-023865-6rafp3x3 228 8 Zhang Zhang NNP cord-023865-6rafp3x3 228 9 et et NNP cord-023865-6rafp3x3 228 10 al al NNP cord-023865-6rafp3x3 228 11 . . . cord-023865-6rafp3x3 229 1 ( ( -LRB- cord-023865-6rafp3x3 229 2 2007 2007 CD cord-023865-6rafp3x3 229 3 ) ) -RRB- cord-023865-6rafp3x3 229 4 . . . cord-023865-6rafp3x3 230 1 They -PRON- PRP cord-023865-6rafp3x3 230 2 reported report VBD cord-023865-6rafp3x3 230 3 that that IN cord-023865-6rafp3x3 230 4 serum serum NN cord-023865-6rafp3x3 230 5 starvationinduced starvationinduce VBN cord-023865-6rafp3x3 230 6 apoptosis apoptosis NN cord-023865-6rafp3x3 230 7 of of IN cord-023865-6rafp3x3 230 8 N n CD cord-023865-6rafp3x3 230 9 - - HYPH cord-023865-6rafp3x3 230 10 protein protein NN cord-023865-6rafp3x3 230 11 - - HYPH cord-023865-6rafp3x3 230 12 expressing express VBG cord-023865-6rafp3x3 230 13 COS-1 COS-1 NNP cord-023865-6rafp3x3 230 14 cells cell NNS cord-023865-6rafp3x3 230 15 involved involve VBD cord-023865-6rafp3x3 230 16 activation activation NN cord-023865-6rafp3x3 230 17 of of IN cord-023865-6rafp3x3 230 18 mitochondrial mitochondrial JJ cord-023865-6rafp3x3 230 19 pathway pathway NN cord-023865-6rafp3x3 230 20 . . . cord-023865-6rafp3x3 231 1 Another another DT cord-023865-6rafp3x3 231 2 elegant elegant JJ cord-023865-6rafp3x3 231 3 study study NN cord-023865-6rafp3x3 231 4 done do VBN cord-023865-6rafp3x3 231 5 by by IN cord-023865-6rafp3x3 231 6 Diemer Diemer NNP cord-023865-6rafp3x3 231 7 et et NNP cord-023865-6rafp3x3 231 8 al al NNP cord-023865-6rafp3x3 231 9 . . . cord-023865-6rafp3x3 232 1 ( ( -LRB- cord-023865-6rafp3x3 232 2 2008 2008 CD cord-023865-6rafp3x3 232 3 ) ) -RRB- cord-023865-6rafp3x3 232 4 has have VBZ cord-023865-6rafp3x3 232 5 further further RB cord-023865-6rafp3x3 232 6 extended extend VBN cord-023865-6rafp3x3 232 7 our -PRON- PRP$ cord-023865-6rafp3x3 232 8 understanding understanding NN cord-023865-6rafp3x3 232 9 regarding regard VBG cord-023865-6rafp3x3 232 10 the the DT cord-023865-6rafp3x3 232 11 apoptotic apoptotic JJ cord-023865-6rafp3x3 232 12 property property NN cord-023865-6rafp3x3 232 13 of of IN cord-023865-6rafp3x3 232 14 the the DT cord-023865-6rafp3x3 232 15 N n NN cord-023865-6rafp3x3 232 16 - - HYPH cord-023865-6rafp3x3 232 17 protein protein NN cord-023865-6rafp3x3 232 18 . . . cord-023865-6rafp3x3 233 1 Through through IN cord-023865-6rafp3x3 233 2 a a DT cord-023865-6rafp3x3 233 3 series series NN cord-023865-6rafp3x3 233 4 of of IN cord-023865-6rafp3x3 233 5 experiments experiment NNS cord-023865-6rafp3x3 233 6 involving involve VBG cord-023865-6rafp3x3 233 7 both both CC cord-023865-6rafp3x3 233 8 a a DT cord-023865-6rafp3x3 233 9 model model NN cord-023865-6rafp3x3 233 10 infection infection NN cord-023865-6rafp3x3 233 11 system system NN cord-023865-6rafp3x3 233 12 of of IN cord-023865-6rafp3x3 233 13 SARS SARS NNP cord-023865-6rafp3x3 233 14 - - HYPH cord-023865-6rafp3x3 233 15 CoV CoV NNP cord-023865-6rafp3x3 233 16 and and CC cord-023865-6rafp3x3 233 17 transient transient JJ cord-023865-6rafp3x3 233 18 transfection transfection NN cord-023865-6rafp3x3 233 19 of of IN cord-023865-6rafp3x3 233 20 N n NN cord-023865-6rafp3x3 233 21 - - HYPH cord-023865-6rafp3x3 233 22 protein protein NN cord-023865-6rafp3x3 233 23 , , , cord-023865-6rafp3x3 233 24 the the DT cord-023865-6rafp3x3 233 25 authors author NNS cord-023865-6rafp3x3 233 26 have have VBP cord-023865-6rafp3x3 233 27 confirmed confirm VBN cord-023865-6rafp3x3 233 28 that that IN cord-023865-6rafp3x3 233 29 N n NN cord-023865-6rafp3x3 233 30 - - HYPH cord-023865-6rafp3x3 233 31 protein protein NN cord-023865-6rafp3x3 233 32 induces induce VBZ cord-023865-6rafp3x3 233 33 an an DT cord-023865-6rafp3x3 233 34 intrinsic intrinsic JJ cord-023865-6rafp3x3 233 35 apoptotic apoptotic JJ cord-023865-6rafp3x3 233 36 pathway pathway NN cord-023865-6rafp3x3 233 37 resulting result VBG cord-023865-6rafp3x3 233 38 in in IN cord-023865-6rafp3x3 233 39 activation activation NN cord-023865-6rafp3x3 233 40 of of IN cord-023865-6rafp3x3 233 41 caspase-9 caspase-9 NNP cord-023865-6rafp3x3 233 42 , , , cord-023865-6rafp3x3 233 43 which which WDT cord-023865-6rafp3x3 233 44 further further RB cord-023865-6rafp3x3 233 45 leads lead VBZ cord-023865-6rafp3x3 233 46 to to IN cord-023865-6rafp3x3 233 47 activation activation NN cord-023865-6rafp3x3 233 48 of of IN cord-023865-6rafp3x3 233 49 caspase-3 caspase-3 NNP cord-023865-6rafp3x3 233 50 and and CC cord-023865-6rafp3x3 233 51 -6 -6 NNP cord-023865-6rafp3x3 233 52 . . . cord-023865-6rafp3x3 234 1 Their -PRON- PRP$ cord-023865-6rafp3x3 234 2 data datum NNS cord-023865-6rafp3x3 234 3 further further RB cord-023865-6rafp3x3 234 4 revealed reveal VBD cord-023865-6rafp3x3 234 5 that that IN cord-023865-6rafp3x3 234 6 these these DT cord-023865-6rafp3x3 234 7 activated activate VBN cord-023865-6rafp3x3 234 8 caspases caspase NNS cord-023865-6rafp3x3 234 9 cleave cleave VBP cord-023865-6rafp3x3 234 10 the the DT cord-023865-6rafp3x3 234 11 N n NN cord-023865-6rafp3x3 234 12 - - HYPH cord-023865-6rafp3x3 234 13 protein protein NN cord-023865-6rafp3x3 234 14 at at IN cord-023865-6rafp3x3 234 15 residues residue NNS cord-023865-6rafp3x3 234 16 400 400 CD cord-023865-6rafp3x3 234 17 and and CC cord-023865-6rafp3x3 234 18 403 403 CD cord-023865-6rafp3x3 234 19 and and CC cord-023865-6rafp3x3 234 20 that that IN cord-023865-6rafp3x3 234 21 nuclear nuclear JJ cord-023865-6rafp3x3 234 22 localization localization NN cord-023865-6rafp3x3 234 23 of of IN cord-023865-6rafp3x3 234 24 N n NN cord-023865-6rafp3x3 234 25 - - HYPH cord-023865-6rafp3x3 234 26 protein protein NN cord-023865-6rafp3x3 234 27 is be VBZ cord-023865-6rafp3x3 234 28 an an DT cord-023865-6rafp3x3 234 29 absolute absolute JJ cord-023865-6rafp3x3 234 30 requirement requirement NN cord-023865-6rafp3x3 234 31 for for IN cord-023865-6rafp3x3 234 32 cleavage cleavage NN cord-023865-6rafp3x3 234 33 . . . cord-023865-6rafp3x3 235 1 In in IN cord-023865-6rafp3x3 235 2 addition addition NN cord-023865-6rafp3x3 235 3 , , , cord-023865-6rafp3x3 235 4 the the DT cord-023865-6rafp3x3 235 5 authors author NNS cord-023865-6rafp3x3 235 6 have have VBP cord-023865-6rafp3x3 235 7 reported report VBN cord-023865-6rafp3x3 235 8 that that IN cord-023865-6rafp3x3 235 9 the the DT cord-023865-6rafp3x3 235 10 apoptosis apoptosis NN cord-023865-6rafp3x3 235 11 - - HYPH cord-023865-6rafp3x3 235 12 inducing induce VBG cord-023865-6rafp3x3 235 13 ability ability NN cord-023865-6rafp3x3 235 14 of of IN cord-023865-6rafp3x3 235 15 the the DT cord-023865-6rafp3x3 235 16 N n CD cord-023865-6rafp3x3 235 17 - - HYPH cord-023865-6rafp3x3 235 18 protein protein NN cord-023865-6rafp3x3 235 19 is be VBZ cord-023865-6rafp3x3 235 20 highly highly RB cord-023865-6rafp3x3 235 21 cell cell NN cord-023865-6rafp3x3 235 22 type type NN cord-023865-6rafp3x3 235 23 specific specific JJ cord-023865-6rafp3x3 235 24 . . . cord-023865-6rafp3x3 236 1 Only only RB cord-023865-6rafp3x3 236 2 in in IN cord-023865-6rafp3x3 236 3 cells cell NNS cord-023865-6rafp3x3 236 4 where where WRB cord-023865-6rafp3x3 236 5 N n NN cord-023865-6rafp3x3 236 6 - - HYPH cord-023865-6rafp3x3 236 7 protein protein NN cord-023865-6rafp3x3 236 8 localizes localize VBZ cord-023865-6rafp3x3 236 9 to to IN cord-023865-6rafp3x3 236 10 both both DT cord-023865-6rafp3x3 236 11 nucleus nucleus NN cord-023865-6rafp3x3 236 12 and and CC cord-023865-6rafp3x3 236 13 cytoplasm cytoplasm JJ cord-023865-6rafp3x3 237 1 ( ( -LRB- cord-023865-6rafp3x3 237 2 Vero Vero NNP cord-023865-6rafp3x3 237 3 E6 E6 NNP cord-023865-6rafp3x3 237 4 and and CC cord-023865-6rafp3x3 237 5 A549 a549 JJ cord-023865-6rafp3x3 237 6 cells cell NNS cord-023865-6rafp3x3 237 7 ) ) -RRB- cord-023865-6rafp3x3 237 8 , , , cord-023865-6rafp3x3 237 9 is be VBZ cord-023865-6rafp3x3 237 10 it -PRON- PRP cord-023865-6rafp3x3 237 11 able able JJ cord-023865-6rafp3x3 237 12 to to TO cord-023865-6rafp3x3 237 13 activate activate VB cord-023865-6rafp3x3 237 14 caspase caspase NN cord-023865-6rafp3x3 237 15 and and CC cord-023865-6rafp3x3 237 16 become become VB cord-023865-6rafp3x3 237 17 cleaved cleave VBN cord-023865-6rafp3x3 237 18 ; ; : cord-023865-6rafp3x3 237 19 however however RB cord-023865-6rafp3x3 237 20 , , , cord-023865-6rafp3x3 237 21 in in IN cord-023865-6rafp3x3 237 22 cell cell NN cord-023865-6rafp3x3 237 23 lines line NNS cord-023865-6rafp3x3 237 24 where where WRB cord-023865-6rafp3x3 237 25 it -PRON- PRP cord-023865-6rafp3x3 237 26 localizes localize VBZ cord-023865-6rafp3x3 237 27 to to IN cord-023865-6rafp3x3 237 28 the the DT cord-023865-6rafp3x3 237 29 cytoplasm cytoplasm NN cord-023865-6rafp3x3 237 30 only only RB cord-023865-6rafp3x3 237 31 ( ( -LRB- cord-023865-6rafp3x3 237 32 Caco2 Caco2 VBN cord-023865-6rafp3x3 237 33 and and CC cord-023865-6rafp3x3 237 34 N-2a N-2a NNP cord-023865-6rafp3x3 237 35 cells cell NNS cord-023865-6rafp3x3 237 36 ) ) -RRB- cord-023865-6rafp3x3 237 37 , , , cord-023865-6rafp3x3 237 38 no no DT cord-023865-6rafp3x3 237 39 activation activation NN cord-023865-6rafp3x3 237 40 of of IN cord-023865-6rafp3x3 237 41 caspase caspase NN cord-023865-6rafp3x3 237 42 is be VBZ cord-023865-6rafp3x3 237 43 observed observe VBN cord-023865-6rafp3x3 237 44 . . . cord-023865-6rafp3x3 238 1 It -PRON- PRP cord-023865-6rafp3x3 238 2 remains remain VBZ cord-023865-6rafp3x3 238 3 to to TO cord-023865-6rafp3x3 238 4 be be VB cord-023865-6rafp3x3 238 5 studied study VBN cord-023865-6rafp3x3 238 6 whether whether IN cord-023865-6rafp3x3 238 7 this this DT cord-023865-6rafp3x3 238 8 phenomenon phenomenon NN cord-023865-6rafp3x3 238 9 is be VBZ cord-023865-6rafp3x3 238 10 actually actually RB cord-023865-6rafp3x3 238 11 recapitulated recapitulate VBN cord-023865-6rafp3x3 238 12 in in IN cord-023865-6rafp3x3 238 13 vivo vivo NN cord-023865-6rafp3x3 238 14 . . . cord-023865-6rafp3x3 239 1 A a DT cord-023865-6rafp3x3 239 2 recent recent JJ cord-023865-6rafp3x3 239 3 report report NN cord-023865-6rafp3x3 239 4 by by IN cord-023865-6rafp3x3 239 5 Han Han NNP cord-023865-6rafp3x3 239 6 et et NNP cord-023865-6rafp3x3 239 7 al al NNP cord-023865-6rafp3x3 239 8 . . . cord-023865-6rafp3x3 240 1 ( ( -LRB- cord-023865-6rafp3x3 240 2 2008 2008 CD cord-023865-6rafp3x3 240 3 ) ) -RRB- cord-023865-6rafp3x3 240 4 revealed reveal VBD cord-023865-6rafp3x3 240 5 that that IN cord-023865-6rafp3x3 240 6 , , , cord-023865-6rafp3x3 240 7 of of IN cord-023865-6rafp3x3 240 8 all all PDT cord-023865-6rafp3x3 240 9 the the DT cord-023865-6rafp3x3 240 10 SARS SARS NNP cord-023865-6rafp3x3 240 11 - - HYPH cord-023865-6rafp3x3 240 12 CoV CoV NNP cord-023865-6rafp3x3 240 13 structural structural JJ cord-023865-6rafp3x3 240 14 proteins protein NNS cord-023865-6rafp3x3 240 15 , , , cord-023865-6rafp3x3 240 16 only only RB cord-023865-6rafp3x3 240 17 N n CD cord-023865-6rafp3x3 240 18 - - HYPH cord-023865-6rafp3x3 240 19 protein protein NN cord-023865-6rafp3x3 240 20 specifically specifically RB cord-023865-6rafp3x3 240 21 induced induce VBD cord-023865-6rafp3x3 240 22 the the DT cord-023865-6rafp3x3 240 23 transcription transcription NN cord-023865-6rafp3x3 240 24 of of IN cord-023865-6rafp3x3 240 25 prothrombinase prothrombinase NNP cord-023865-6rafp3x3 240 26 gene gene NN cord-023865-6rafp3x3 240 27 in in IN cord-023865-6rafp3x3 240 28 THP-1 THP-1 NNP cord-023865-6rafp3x3 240 29 and and CC cord-023865-6rafp3x3 240 30 Vero Vero NNP cord-023865-6rafp3x3 240 31 cells cell NNS cord-023865-6rafp3x3 240 32 . . . cord-023865-6rafp3x3 241 1 By by IN cord-023865-6rafp3x3 241 2 performing perform VBG cord-023865-6rafp3x3 241 3 luciferase luciferase NN cord-023865-6rafp3x3 241 4 reporter reporter NN cord-023865-6rafp3x3 241 5 assay assay NN cord-023865-6rafp3x3 241 6 of of IN cord-023865-6rafp3x3 241 7 hfgl2 hfgl2 NN cord-023865-6rafp3x3 241 8 promoter promoter NN cord-023865-6rafp3x3 241 9 in in IN cord-023865-6rafp3x3 241 10 N n CD cord-023865-6rafp3x3 241 11 - - HYPH cord-023865-6rafp3x3 241 12 protein protein NN cord-023865-6rafp3x3 241 13 - - HYPH cord-023865-6rafp3x3 241 14 expressing express VBG cord-023865-6rafp3x3 241 15 cells cell NNS cord-023865-6rafp3x3 241 16 and and CC cord-023865-6rafp3x3 241 17 electrophoretic electrophoretic JJ cord-023865-6rafp3x3 241 18 mobility mobility NN cord-023865-6rafp3x3 241 19 shift shift NN cord-023865-6rafp3x3 241 20 assay assay NN cord-023865-6rafp3x3 241 21 using use VBG cord-023865-6rafp3x3 241 22 N n CD cord-023865-6rafp3x3 241 23 - - HYPH cord-023865-6rafp3x3 241 24 protein protein NN cord-023865-6rafp3x3 241 25 - - HYPH cord-023865-6rafp3x3 241 26 transfected transfecte VBN cord-023865-6rafp3x3 241 27 cell cell NN cord-023865-6rafp3x3 241 28 lysate lysate NN cord-023865-6rafp3x3 241 29 , , , cord-023865-6rafp3x3 241 30 they -PRON- PRP cord-023865-6rafp3x3 241 31 demonstrated demonstrate VBD cord-023865-6rafp3x3 241 32 that that IN cord-023865-6rafp3x3 241 33 N n CD cord-023865-6rafp3x3 241 34 - - HYPH cord-023865-6rafp3x3 241 35 protein protein NN cord-023865-6rafp3x3 241 36 expression expression NN cord-023865-6rafp3x3 241 37 induced induce VBD cord-023865-6rafp3x3 241 38 the the DT cord-023865-6rafp3x3 241 39 binding binding NN cord-023865-6rafp3x3 241 40 of of IN cord-023865-6rafp3x3 241 41 transcription transcription NN cord-023865-6rafp3x3 241 42 factor factor NN cord-023865-6rafp3x3 241 43 C C NNP cord-023865-6rafp3x3 241 44 / / SYM cord-023865-6rafp3x3 241 45 EBPa EBPa NNS cord-023865-6rafp3x3 241 46 to to IN cord-023865-6rafp3x3 241 47 its -PRON- PRP$ cord-023865-6rafp3x3 241 48 cognate cognate JJ cord-023865-6rafp3x3 241 49 response response NN cord-023865-6rafp3x3 241 50 element element NN cord-023865-6rafp3x3 241 51 present present JJ cord-023865-6rafp3x3 241 52 in in IN cord-023865-6rafp3x3 241 53 hfgl2 hfgl2 NN cord-023865-6rafp3x3 241 54 promoter promoter NN cord-023865-6rafp3x3 241 55 , , , cord-023865-6rafp3x3 241 56 leading lead VBG cord-023865-6rafp3x3 241 57 to to IN cord-023865-6rafp3x3 241 58 enhanced enhanced JJ cord-023865-6rafp3x3 241 59 transcription transcription NN cord-023865-6rafp3x3 241 60 of of IN cord-023865-6rafp3x3 241 61 hfgl2 hfgl2 NN cord-023865-6rafp3x3 241 62 gene gene NN cord-023865-6rafp3x3 241 63 . . . cord-023865-6rafp3x3 242 1 Since since IN cord-023865-6rafp3x3 242 2 lungs lung NNS cord-023865-6rafp3x3 242 3 of of IN cord-023865-6rafp3x3 242 4 SARS SARS NNP cord-023865-6rafp3x3 242 5 patients patient NNS cord-023865-6rafp3x3 242 6 have have VBP cord-023865-6rafp3x3 242 7 been be VBN cord-023865-6rafp3x3 242 8 shown show VBN cord-023865-6rafp3x3 242 9 to to TO cord-023865-6rafp3x3 242 10 contain contain VB cord-023865-6rafp3x3 242 11 high high JJ cord-023865-6rafp3x3 242 12 amount amount NN cord-023865-6rafp3x3 242 13 of of IN cord-023865-6rafp3x3 242 14 fibrin fibrin NN cord-023865-6rafp3x3 242 15 , , , cord-023865-6rafp3x3 242 16 the the DT cord-023865-6rafp3x3 242 17 authors author NNS cord-023865-6rafp3x3 242 18 proposed propose VBD cord-023865-6rafp3x3 242 19 that that IN cord-023865-6rafp3x3 242 20 N n NN cord-023865-6rafp3x3 242 21 - - HYPH cord-023865-6rafp3x3 242 22 protein protein NN cord-023865-6rafp3x3 242 23 - - HYPH cord-023865-6rafp3x3 242 24 mediated mediate VBN cord-023865-6rafp3x3 242 25 enhanced enhanced JJ cord-023865-6rafp3x3 242 26 production production NN cord-023865-6rafp3x3 242 27 of of IN cord-023865-6rafp3x3 242 28 prothrombinase prothrombinase NNP cord-023865-6rafp3x3 242 29 gene gene NN cord-023865-6rafp3x3 242 30 may may MD cord-023865-6rafp3x3 242 31 contribute contribute VB cord-023865-6rafp3x3 242 32 to to IN cord-023865-6rafp3x3 242 33 the the DT cord-023865-6rafp3x3 242 34 development development NN cord-023865-6rafp3x3 242 35 of of IN cord-023865-6rafp3x3 242 36 thrombosis thrombosis NN cord-023865-6rafp3x3 242 37 in in IN cord-023865-6rafp3x3 242 38 SARS SARS NNP cord-023865-6rafp3x3 242 39 patients patient NNS cord-023865-6rafp3x3 242 40 . . . cord-023865-6rafp3x3 243 1 Luo Luo NNP cord-023865-6rafp3x3 243 2 et et NNP cord-023865-6rafp3x3 243 3 al al NNP cord-023865-6rafp3x3 243 4 . . . cord-023865-6rafp3x3 244 1 ( ( -LRB- cord-023865-6rafp3x3 244 2 2005 2005 CD cord-023865-6rafp3x3 244 3 ) ) -RRB- cord-023865-6rafp3x3 244 4 have have VBP cord-023865-6rafp3x3 244 5 reported report VBN cord-023865-6rafp3x3 244 6 the the DT cord-023865-6rafp3x3 244 7 interaction interaction NN cord-023865-6rafp3x3 244 8 between between IN cord-023865-6rafp3x3 244 9 hnRNPA1 hnRNPA1 NNP cord-023865-6rafp3x3 244 10 and and CC cord-023865-6rafp3x3 244 11 N n NN cord-023865-6rafp3x3 244 12 - - HYPH cord-023865-6rafp3x3 244 13 protein protein NN cord-023865-6rafp3x3 244 14 by by IN cord-023865-6rafp3x3 244 15 using use VBG cord-023865-6rafp3x3 244 16 a a DT cord-023865-6rafp3x3 244 17 variety variety NN cord-023865-6rafp3x3 244 18 of of IN cord-023865-6rafp3x3 244 19 biochemical biochemical JJ cord-023865-6rafp3x3 244 20 and and CC cord-023865-6rafp3x3 244 21 genetic genetic JJ cord-023865-6rafp3x3 244 22 assays assay NNS cord-023865-6rafp3x3 244 23 . . . cord-023865-6rafp3x3 245 1 The the DT cord-023865-6rafp3x3 245 2 interaction interaction NN cord-023865-6rafp3x3 245 3 was be VBD cord-023865-6rafp3x3 245 4 found find VBN cord-023865-6rafp3x3 245 5 to to TO cord-023865-6rafp3x3 245 6 be be VB cord-023865-6rafp3x3 245 7 mediated mediate VBN cord-023865-6rafp3x3 245 8 through through IN cord-023865-6rafp3x3 245 9 the the DT cord-023865-6rafp3x3 245 10 middle middle JJ cord-023865-6rafp3x3 245 11 region region NN cord-023865-6rafp3x3 245 12 ( ( -LRB- cord-023865-6rafp3x3 245 13 aa aa NNP cord-023865-6rafp3x3 245 14 161 161 CD cord-023865-6rafp3x3 245 15 - - HYPH cord-023865-6rafp3x3 245 16 210 210 CD cord-023865-6rafp3x3 245 17 ) ) -RRB- cord-023865-6rafp3x3 245 18 of of IN cord-023865-6rafp3x3 245 19 N n NN cord-023865-6rafp3x3 245 20 - - HYPH cord-023865-6rafp3x3 245 21 protein protein NN cord-023865-6rafp3x3 245 22 . . . cord-023865-6rafp3x3 246 1 If if IN cord-023865-6rafp3x3 246 2 relevant relevant JJ cord-023865-6rafp3x3 246 3 in in IN cord-023865-6rafp3x3 246 4 vivo vivo NN cord-023865-6rafp3x3 246 5 , , , cord-023865-6rafp3x3 246 6 this this DT cord-023865-6rafp3x3 246 7 interaction interaction NN cord-023865-6rafp3x3 246 8 may may MD cord-023865-6rafp3x3 246 9 play play VB cord-023865-6rafp3x3 246 10 a a DT cord-023865-6rafp3x3 246 11 significant significant JJ cord-023865-6rafp3x3 246 12 role role NN cord-023865-6rafp3x3 246 13 in in IN cord-023865-6rafp3x3 246 14 regulation regulation NN cord-023865-6rafp3x3 246 15 of of IN cord-023865-6rafp3x3 246 16 the the DT cord-023865-6rafp3x3 246 17 viral viral JJ cord-023865-6rafp3x3 246 18 RNA RNA NNP cord-023865-6rafp3x3 246 19 synthesis synthesis NN cord-023865-6rafp3x3 246 20 . . . cord-023865-6rafp3x3 247 1 Another another DT cord-023865-6rafp3x3 247 2 interesting interesting JJ cord-023865-6rafp3x3 247 3 study study NN cord-023865-6rafp3x3 247 4 done do VBN cord-023865-6rafp3x3 247 5 by by IN cord-023865-6rafp3x3 247 6 Luo Luo NNP cord-023865-6rafp3x3 247 7 et et NNP cord-023865-6rafp3x3 247 8 al al NNP cord-023865-6rafp3x3 247 9 . . . cord-023865-6rafp3x3 248 1 ( ( -LRB- cord-023865-6rafp3x3 248 2 2004a 2004a CD cord-023865-6rafp3x3 248 3 ) ) -RRB- cord-023865-6rafp3x3 248 4 has have VBZ cord-023865-6rafp3x3 248 5 reported report VBN cord-023865-6rafp3x3 248 6 association association NN cord-023865-6rafp3x3 248 7 between between IN cord-023865-6rafp3x3 248 8 the the DT cord-023865-6rafp3x3 248 9 N N NNP cord-023865-6rafp3x3 248 10 - - HYPH cord-023865-6rafp3x3 248 11 protein protein NN cord-023865-6rafp3x3 248 12 and and CC cord-023865-6rafp3x3 248 13 human human JJ cord-023865-6rafp3x3 248 14 cyclophylin cyclophylin NN cord-023865-6rafp3x3 248 15 A. a. NN cord-023865-6rafp3x3 249 1 By by IN cord-023865-6rafp3x3 249 2 SPR SPR NNP cord-023865-6rafp3x3 249 3 ( ( -LRB- cord-023865-6rafp3x3 249 4 Surface Surface NNP cord-023865-6rafp3x3 249 5 Plasmn Plasmn NNP cord-023865-6rafp3x3 249 6 resonance resonance NN cord-023865-6rafp3x3 249 7 ) ) -RRB- cord-023865-6rafp3x3 249 8 analysis analysis NN cord-023865-6rafp3x3 249 9 they -PRON- PRP cord-023865-6rafp3x3 249 10 have have VBP cord-023865-6rafp3x3 249 11 shown show VBN cord-023865-6rafp3x3 249 12 it -PRON- PRP cord-023865-6rafp3x3 249 13 to to TO cord-023865-6rafp3x3 249 14 be be VB cord-023865-6rafp3x3 249 15 a a DT cord-023865-6rafp3x3 249 16 high high JJ cord-023865-6rafp3x3 249 17 affinity affinity NN cord-023865-6rafp3x3 249 18 interaction interaction NN cord-023865-6rafp3x3 249 19 . . . cord-023865-6rafp3x3 250 1 Although although IN cord-023865-6rafp3x3 250 2 the the DT cord-023865-6rafp3x3 250 3 significance significance NN cord-023865-6rafp3x3 250 4 of of IN cord-023865-6rafp3x3 250 5 this this DT cord-023865-6rafp3x3 250 6 interaction interaction NN cord-023865-6rafp3x3 250 7 is be VBZ cord-023865-6rafp3x3 250 8 not not RB cord-023865-6rafp3x3 250 9 known know VBN cord-023865-6rafp3x3 250 10 in in IN cord-023865-6rafp3x3 250 11 vivo vivo NN cord-023865-6rafp3x3 250 12 , , , cord-023865-6rafp3x3 250 13 they -PRON- PRP cord-023865-6rafp3x3 250 14 have have VBP cord-023865-6rafp3x3 250 15 proposed propose VBN cord-023865-6rafp3x3 250 16 that that IN cord-023865-6rafp3x3 250 17 this this DT cord-023865-6rafp3x3 250 18 interaction interaction NN cord-023865-6rafp3x3 250 19 might may MD cord-023865-6rafp3x3 250 20 be be VB cord-023865-6rafp3x3 250 21 crucial crucial JJ cord-023865-6rafp3x3 250 22 for for IN cord-023865-6rafp3x3 250 23 viral viral JJ cord-023865-6rafp3x3 250 24 infection infection NN cord-023865-6rafp3x3 250 25 . . . cord-023865-6rafp3x3 251 1 Notable notable JJ cord-023865-6rafp3x3 251 2 is be VBZ cord-023865-6rafp3x3 251 3 the the DT cord-023865-6rafp3x3 251 4 fact fact NN cord-023865-6rafp3x3 251 5 that that IN cord-023865-6rafp3x3 251 6 HIV-1 HIV-1 NNP cord-023865-6rafp3x3 251 7 gag gag NN cord-023865-6rafp3x3 251 8 also also RB cord-023865-6rafp3x3 251 9 binds bind VBZ cord-023865-6rafp3x3 251 10 with with IN cord-023865-6rafp3x3 251 11 human human JJ cord-023865-6rafp3x3 251 12 cyclophylin cyclophylin NN cord-023865-6rafp3x3 251 13 A A NNP cord-023865-6rafp3x3 251 14 and and CC cord-023865-6rafp3x3 251 15 this this DT cord-023865-6rafp3x3 251 16 interaction interaction NN cord-023865-6rafp3x3 251 17 is be VBZ cord-023865-6rafp3x3 251 18 crucial crucial JJ cord-023865-6rafp3x3 251 19 for for IN cord-023865-6rafp3x3 251 20 HIV HIV NNP cord-023865-6rafp3x3 251 21 infection infection NN cord-023865-6rafp3x3 252 1 ( ( -LRB- cord-023865-6rafp3x3 252 2 Gamble Gamble NNP cord-023865-6rafp3x3 252 3 et et FW cord-023865-6rafp3x3 252 4 al al NNP cord-023865-6rafp3x3 252 5 . . . cord-023865-6rafp3x3 252 6 1996 1996 CD cord-023865-6rafp3x3 252 7 ) ) -RRB- cord-023865-6rafp3x3 252 8 . . . cord-023865-6rafp3x3 253 1 Recently recently RB cord-023865-6rafp3x3 253 2 , , , cord-023865-6rafp3x3 253 3 Zeng Zeng NNP cord-023865-6rafp3x3 253 4 et et FW cord-023865-6rafp3x3 253 5 al al NNP cord-023865-6rafp3x3 253 6 . . . cord-023865-6rafp3x3 254 1 ( ( -LRB- cord-023865-6rafp3x3 254 2 2008 2008 CD cord-023865-6rafp3x3 254 3 ) ) -RRB- cord-023865-6rafp3x3 254 4 have have VBP cord-023865-6rafp3x3 254 5 reported report VBN cord-023865-6rafp3x3 254 6 that that IN cord-023865-6rafp3x3 254 7 N n CD cord-023865-6rafp3x3 254 8 - - HYPH cord-023865-6rafp3x3 254 9 protein protein NN cord-023865-6rafp3x3 254 10 associates associate NNS cord-023865-6rafp3x3 254 11 with with IN cord-023865-6rafp3x3 254 12 B23 B23 NNP cord-023865-6rafp3x3 254 13 , , , cord-023865-6rafp3x3 254 14 a a DT cord-023865-6rafp3x3 254 15 phosphoprotein phosphoprotein NN cord-023865-6rafp3x3 254 16 in in IN cord-023865-6rafp3x3 254 17 the the DT cord-023865-6rafp3x3 254 18 nucleus nucleus NN cord-023865-6rafp3x3 254 19 . . . cord-023865-6rafp3x3 255 1 By by IN cord-023865-6rafp3x3 255 2 performing perform VBG cord-023865-6rafp3x3 255 3 in in IN cord-023865-6rafp3x3 255 4 vivo vivo NNP cord-023865-6rafp3x3 255 5 coimmunoprecipitation coimmunoprecipitation NN cord-023865-6rafp3x3 255 6 in in IN cord-023865-6rafp3x3 255 7 hela hela NNP cord-023865-6rafp3x3 255 8 cells cell NNS cord-023865-6rafp3x3 255 9 and and CC cord-023865-6rafp3x3 255 10 GST GST NNP cord-023865-6rafp3x3 255 11 pull pull VB cord-023865-6rafp3x3 255 12 - - HYPH cord-023865-6rafp3x3 255 13 down down RP cord-023865-6rafp3x3 255 14 assay assay NN cord-023865-6rafp3x3 255 15 using use VBG cord-023865-6rafp3x3 255 16 purified purify VBN cord-023865-6rafp3x3 255 17 recombinant recombinant JJ cord-023865-6rafp3x3 255 18 N n NN cord-023865-6rafp3x3 255 19 - - HYPH cord-023865-6rafp3x3 255 20 protein protein NN cord-023865-6rafp3x3 255 21 , , , cord-023865-6rafp3x3 255 22 the the DT cord-023865-6rafp3x3 255 23 authors author NNS cord-023865-6rafp3x3 255 24 have have VBP cord-023865-6rafp3x3 255 25 demonstrated demonstrate VBN cord-023865-6rafp3x3 255 26 direct direct JJ cord-023865-6rafp3x3 255 27 interaction interaction NN cord-023865-6rafp3x3 255 28 between between IN cord-023865-6rafp3x3 255 29 B23 B23 NNP cord-023865-6rafp3x3 255 30 and and CC cord-023865-6rafp3x3 255 31 N N NNP cord-023865-6rafp3x3 255 32 - - HYPH cord-023865-6rafp3x3 255 33 protein protein NN cord-023865-6rafp3x3 255 34 . . . cord-023865-6rafp3x3 256 1 The the DT cord-023865-6rafp3x3 256 2 interaction interaction NN cord-023865-6rafp3x3 256 3 domain domain NN cord-023865-6rafp3x3 256 4 has have VBZ cord-023865-6rafp3x3 256 5 been be VBN cord-023865-6rafp3x3 256 6 mapped map VBN cord-023865-6rafp3x3 256 7 to to IN cord-023865-6rafp3x3 256 8 amino amino NN cord-023865-6rafp3x3 256 9 acid acid NN cord-023865-6rafp3x3 256 10 residues residue NNS cord-023865-6rafp3x3 256 11 175 175 CD cord-023865-6rafp3x3 256 12 - - SYM cord-023865-6rafp3x3 256 13 210 210 CD cord-023865-6rafp3x3 256 14 of of IN cord-023865-6rafp3x3 256 15 N n NN cord-023865-6rafp3x3 256 16 - - HYPH cord-023865-6rafp3x3 256 17 protein protein NN cord-023865-6rafp3x3 256 18 , , , cord-023865-6rafp3x3 256 19 which which WDT cord-023865-6rafp3x3 256 20 include include VBP cord-023865-6rafp3x3 256 21 the the DT cord-023865-6rafp3x3 256 22 SR SR NNP cord-023865-6rafp3x3 256 23 - - HYPH cord-023865-6rafp3x3 256 24 rich rich JJ cord-023865-6rafp3x3 256 25 motif motif NN cord-023865-6rafp3x3 256 26 . . . cord-023865-6rafp3x3 257 1 B23 B23 NNP cord-023865-6rafp3x3 257 2 plays play VBZ cord-023865-6rafp3x3 257 3 a a DT cord-023865-6rafp3x3 257 4 key key JJ cord-023865-6rafp3x3 257 5 role role NN cord-023865-6rafp3x3 257 6 in in IN cord-023865-6rafp3x3 257 7 centrosome centrosome NN cord-023865-6rafp3x3 257 8 duplication duplication NN cord-023865-6rafp3x3 257 9 during during IN cord-023865-6rafp3x3 257 10 cell cell NN cord-023865-6rafp3x3 257 11 division division NN cord-023865-6rafp3x3 257 12 . . . cord-023865-6rafp3x3 258 1 Phosphorylation Phosphorylation NNP cord-023865-6rafp3x3 258 2 of of IN cord-023865-6rafp3x3 258 3 B23 B23 NNP cord-023865-6rafp3x3 258 4 at at IN cord-023865-6rafp3x3 258 5 threonine-199 threonine-199 CD cord-023865-6rafp3x3 258 6 residue residue NN cord-023865-6rafp3x3 258 7 is be VBZ cord-023865-6rafp3x3 258 8 known know VBN cord-023865-6rafp3x3 258 9 to to TO cord-023865-6rafp3x3 258 10 regulate regulate VB cord-023865-6rafp3x3 258 11 its -PRON- PRP$ cord-023865-6rafp3x3 258 12 function function NN cord-023865-6rafp3x3 258 13 ( ( -LRB- cord-023865-6rafp3x3 258 14 Okuda Okuda NNP cord-023865-6rafp3x3 258 15 et et FW cord-023865-6rafp3x3 258 16 al al NNP cord-023865-6rafp3x3 258 17 . . . cord-023865-6rafp3x3 259 1 2000 2000 CD cord-023865-6rafp3x3 259 2 , , , cord-023865-6rafp3x3 259 3 Tokuyama Tokuyama NNP cord-023865-6rafp3x3 259 4 et et NNP cord-023865-6rafp3x3 259 5 al al NNP cord-023865-6rafp3x3 259 6 . . . cord-023865-6rafp3x3 260 1 2001 2001 CD cord-023865-6rafp3x3 260 2 . . . cord-023865-6rafp3x3 261 1 In in IN cord-023865-6rafp3x3 261 2 order order NN cord-023865-6rafp3x3 261 3 to to TO cord-023865-6rafp3x3 261 4 demonstrate demonstrate VB cord-023865-6rafp3x3 261 5 the the DT cord-023865-6rafp3x3 261 6 functional functional JJ cord-023865-6rafp3x3 261 7 significance significance NN cord-023865-6rafp3x3 261 8 of of IN cord-023865-6rafp3x3 261 9 N n CD cord-023865-6rafp3x3 261 10 - - HYPH cord-023865-6rafp3x3 261 11 protein protein NN cord-023865-6rafp3x3 261 12 interaction interaction NN cord-023865-6rafp3x3 261 13 with with IN cord-023865-6rafp3x3 261 14 B23 B23 NNP cord-023865-6rafp3x3 261 15 protein protein NN cord-023865-6rafp3x3 261 16 , , , cord-023865-6rafp3x3 261 17 the the DT cord-023865-6rafp3x3 261 18 authors author NNS cord-023865-6rafp3x3 261 19 tested test VBD cord-023865-6rafp3x3 261 20 the the DT cord-023865-6rafp3x3 261 21 phosphorylation phosphorylation NN cord-023865-6rafp3x3 261 22 status status NN cord-023865-6rafp3x3 261 23 of of IN cord-023865-6rafp3x3 261 24 threonine-199 threonine-199 CD cord-023865-6rafp3x3 261 25 residue residue NN cord-023865-6rafp3x3 261 26 of of IN cord-023865-6rafp3x3 261 27 B23 B23 NNP cord-023865-6rafp3x3 261 28 in in IN cord-023865-6rafp3x3 261 29 the the DT cord-023865-6rafp3x3 261 30 presence presence NN cord-023865-6rafp3x3 261 31 of of IN cord-023865-6rafp3x3 261 32 N n NN cord-023865-6rafp3x3 261 33 - - HYPH cord-023865-6rafp3x3 261 34 protein protein NN cord-023865-6rafp3x3 261 35 . . . cord-023865-6rafp3x3 262 1 Interestingly interestingly RB cord-023865-6rafp3x3 262 2 , , , cord-023865-6rafp3x3 262 3 N n CD cord-023865-6rafp3x3 262 4 - - HYPH cord-023865-6rafp3x3 262 5 protein protein NN cord-023865-6rafp3x3 262 6 was be VBD cord-023865-6rafp3x3 262 7 able able JJ cord-023865-6rafp3x3 262 8 to to TO cord-023865-6rafp3x3 262 9 block block VB cord-023865-6rafp3x3 262 10 threonine-199 threonine-199 CD cord-023865-6rafp3x3 262 11 phosphorylation phosphorylation NN cord-023865-6rafp3x3 262 12 . . . cord-023865-6rafp3x3 263 1 Based base VBN cord-023865-6rafp3x3 263 2 on on IN cord-023865-6rafp3x3 263 3 this this DT cord-023865-6rafp3x3 263 4 observation observation NN cord-023865-6rafp3x3 263 5 , , , cord-023865-6rafp3x3 263 6 the the DT cord-023865-6rafp3x3 263 7 authors author NNS cord-023865-6rafp3x3 263 8 have have VBP cord-023865-6rafp3x3 263 9 proposed propose VBN cord-023865-6rafp3x3 263 10 that that IN cord-023865-6rafp3x3 263 11 N n NN cord-023865-6rafp3x3 263 12 - - HYPH cord-023865-6rafp3x3 263 13 protein protein NN cord-023865-6rafp3x3 263 14 exerts exert VBZ cord-023865-6rafp3x3 263 15 its -PRON- PRP$ cord-023865-6rafp3x3 263 16 effect effect NN cord-023865-6rafp3x3 263 17 on on IN cord-023865-6rafp3x3 263 18 cell cell NN cord-023865-6rafp3x3 263 19 cycle cycle NN cord-023865-6rafp3x3 263 20 deregulation deregulation NN cord-023865-6rafp3x3 263 21 by by IN cord-023865-6rafp3x3 263 22 modulating modulate VBG cord-023865-6rafp3x3 263 23 the the DT cord-023865-6rafp3x3 263 24 activity activity NN cord-023865-6rafp3x3 263 25 of of IN cord-023865-6rafp3x3 263 26 B23 B23 NNP cord-023865-6rafp3x3 263 27 protein protein NN cord-023865-6rafp3x3 263 28 . . . cord-023865-6rafp3x3 264 1 In in IN cord-023865-6rafp3x3 264 2 summary summary NN cord-023865-6rafp3x3 264 3 , , , cord-023865-6rafp3x3 264 4 although although IN cord-023865-6rafp3x3 264 5 several several JJ cord-023865-6rafp3x3 264 6 regulatory regulatory JJ cord-023865-6rafp3x3 264 7 roles role NNS cord-023865-6rafp3x3 264 8 have have VBP cord-023865-6rafp3x3 264 9 been be VBN cord-023865-6rafp3x3 264 10 proposed propose VBN cord-023865-6rafp3x3 264 11 for for IN cord-023865-6rafp3x3 264 12 the the DT cord-023865-6rafp3x3 264 13 SARS SARS NNP cord-023865-6rafp3x3 264 14 - - HYPH cord-023865-6rafp3x3 264 15 CoV CoV NNP cord-023865-6rafp3x3 264 16 N N NNP cord-023865-6rafp3x3 264 17 - - HYPH cord-023865-6rafp3x3 264 18 protein protein NN cord-023865-6rafp3x3 264 19 using use VBG cord-023865-6rafp3x3 264 20 a a DT cord-023865-6rafp3x3 264 21 variety variety NN cord-023865-6rafp3x3 264 22 of of IN cord-023865-6rafp3x3 264 23 in in IN cord-023865-6rafp3x3 264 24 - - HYPH cord-023865-6rafp3x3 264 25 vitro vitro FW cord-023865-6rafp3x3 264 26 experimental experimental JJ cord-023865-6rafp3x3 264 27 systems system NNS cord-023865-6rafp3x3 264 28 , , , cord-023865-6rafp3x3 264 29 no no DT cord-023865-6rafp3x3 264 30 clear clear JJ cord-023865-6rafp3x3 264 31 evidence evidence NN cord-023865-6rafp3x3 264 32 exists exist VBZ cord-023865-6rafp3x3 264 33 for for IN cord-023865-6rafp3x3 264 34 their -PRON- PRP$ cord-023865-6rafp3x3 264 35 occurrence occurrence NN cord-023865-6rafp3x3 264 36 in in IN cord-023865-6rafp3x3 264 37 vivo vivo NN cord-023865-6rafp3x3 264 38 . . . cord-023865-6rafp3x3 265 1 In in IN cord-023865-6rafp3x3 265 2 the the DT cord-023865-6rafp3x3 265 3 absence absence NN cord-023865-6rafp3x3 265 4 of of IN cord-023865-6rafp3x3 265 5 a a DT cord-023865-6rafp3x3 265 6 suitable suitable JJ cord-023865-6rafp3x3 265 7 in in IN cord-023865-6rafp3x3 265 8 - - HYPH cord-023865-6rafp3x3 265 9 vivo vivo NN cord-023865-6rafp3x3 265 10 experimental experimental JJ cord-023865-6rafp3x3 265 11 system system NN cord-023865-6rafp3x3 265 12 , , , cord-023865-6rafp3x3 265 13 all all PDT cord-023865-6rafp3x3 265 14 these these DT cord-023865-6rafp3x3 265 15 functions function NNS cord-023865-6rafp3x3 265 16 remain remain VBP cord-023865-6rafp3x3 265 17 speculative speculative JJ cord-023865-6rafp3x3 265 18 . . . cord-023865-6rafp3x3 266 1 One one CD cord-023865-6rafp3x3 266 2 of of IN cord-023865-6rafp3x3 266 3 the the DT cord-023865-6rafp3x3 266 4 most most RBS cord-023865-6rafp3x3 266 5 essential essential JJ cord-023865-6rafp3x3 266 6 steps step NNS cord-023865-6rafp3x3 266 7 to to TO cord-023865-6rafp3x3 266 8 limit limit VB cord-023865-6rafp3x3 266 9 the the DT cord-023865-6rafp3x3 266 10 outbreak outbreak NN cord-023865-6rafp3x3 266 11 of of IN cord-023865-6rafp3x3 266 12 any any DT cord-023865-6rafp3x3 266 13 infectious infectious JJ cord-023865-6rafp3x3 266 14 disease disease NN cord-023865-6rafp3x3 266 15 is be VBZ cord-023865-6rafp3x3 266 16 the the DT cord-023865-6rafp3x3 266 17 ability ability NN cord-023865-6rafp3x3 266 18 to to TO cord-023865-6rafp3x3 266 19 diagnose diagnose VB cord-023865-6rafp3x3 266 20 the the DT cord-023865-6rafp3x3 266 21 causative causative JJ cord-023865-6rafp3x3 266 22 agent agent NN cord-023865-6rafp3x3 266 23 at at IN cord-023865-6rafp3x3 266 24 the the DT cord-023865-6rafp3x3 266 25 earliest early JJS cord-023865-6rafp3x3 266 26 possible possible JJ cord-023865-6rafp3x3 266 27 time time NN cord-023865-6rafp3x3 266 28 , , , cord-023865-6rafp3x3 266 29 which which WDT cord-023865-6rafp3x3 266 30 can can MD cord-023865-6rafp3x3 266 31 be be VB cord-023865-6rafp3x3 266 32 achieved achieve VBN cord-023865-6rafp3x3 266 33 by by IN cord-023865-6rafp3x3 266 34 detecting detect VBG cord-023865-6rafp3x3 266 35 some some DT cord-023865-6rafp3x3 266 36 of of IN cord-023865-6rafp3x3 266 37 the the DT cord-023865-6rafp3x3 266 38 markers marker NNS cord-023865-6rafp3x3 266 39 that that WDT cord-023865-6rafp3x3 266 40 are be VBP cord-023865-6rafp3x3 266 41 specifically specifically RB cord-023865-6rafp3x3 266 42 expressed express VBN cord-023865-6rafp3x3 266 43 by by IN cord-023865-6rafp3x3 266 44 the the DT cord-023865-6rafp3x3 266 45 pathogen pathogen NN cord-023865-6rafp3x3 266 46 or or CC cord-023865-6rafp3x3 266 47 by by IN cord-023865-6rafp3x3 266 48 identifying identify VBG cord-023865-6rafp3x3 266 49 some some DT cord-023865-6rafp3x3 266 50 of of IN cord-023865-6rafp3x3 266 51 the the DT cord-023865-6rafp3x3 266 52 host host NN cord-023865-6rafp3x3 266 53 factors factor NNS cord-023865-6rafp3x3 266 54 that that WDT cord-023865-6rafp3x3 266 55 are be VBP cord-023865-6rafp3x3 266 56 specifically specifically RB cord-023865-6rafp3x3 266 57 produced produce VBN cord-023865-6rafp3x3 266 58 during during IN cord-023865-6rafp3x3 266 59 infection infection NN cord-023865-6rafp3x3 266 60 . . . cord-023865-6rafp3x3 267 1 N n NN cord-023865-6rafp3x3 267 2 - - HYPH cord-023865-6rafp3x3 267 3 protein protein NN cord-023865-6rafp3x3 267 4 , , , cord-023865-6rafp3x3 267 5 being be VBG cord-023865-6rafp3x3 267 6 one one CD cord-023865-6rafp3x3 267 7 of of IN cord-023865-6rafp3x3 267 8 the the DT cord-023865-6rafp3x3 267 9 predominantly predominantly RB cord-023865-6rafp3x3 267 10 expressed express VBN cord-023865-6rafp3x3 267 11 proteins protein NNS cord-023865-6rafp3x3 267 12 at at IN cord-023865-6rafp3x3 267 13 the the DT cord-023865-6rafp3x3 267 14 early early JJ cord-023865-6rafp3x3 267 15 stage stage NN cord-023865-6rafp3x3 267 16 of of IN cord-023865-6rafp3x3 267 17 SARS SARS NNP cord-023865-6rafp3x3 267 18 - - HYPH cord-023865-6rafp3x3 267 19 CoV CoV NNP cord-023865-6rafp3x3 267 20 infection infection NN cord-023865-6rafp3x3 267 21 , , , cord-023865-6rafp3x3 267 22 against against IN cord-023865-6rafp3x3 267 23 which which WDT cord-023865-6rafp3x3 267 24 a a DT cord-023865-6rafp3x3 267 25 strong strong JJ cord-023865-6rafp3x3 267 26 antibody antibody NN cord-023865-6rafp3x3 267 27 response response NN cord-023865-6rafp3x3 267 28 is be VBZ cord-023865-6rafp3x3 267 29 initiated initiate VBN cord-023865-6rafp3x3 267 30 by by IN cord-023865-6rafp3x3 267 31 the the DT cord-023865-6rafp3x3 267 32 host host NN cord-023865-6rafp3x3 267 33 , , , cord-023865-6rafp3x3 267 34 has have VBZ cord-023865-6rafp3x3 267 35 been be VBN cord-023865-6rafp3x3 267 36 proposed propose VBN cord-023865-6rafp3x3 267 37 to to TO cord-023865-6rafp3x3 267 38 be be VB cord-023865-6rafp3x3 267 39 an an DT cord-023865-6rafp3x3 267 40 attractive attractive JJ cord-023865-6rafp3x3 267 41 diagnostic diagnostic JJ cord-023865-6rafp3x3 267 42 tool tool NN cord-023865-6rafp3x3 267 43 . . . cord-023865-6rafp3x3 268 1 In in IN cord-023865-6rafp3x3 268 2 serum serum NN cord-023865-6rafp3x3 268 3 of of IN cord-023865-6rafp3x3 268 4 SARS SARS NNP cord-023865-6rafp3x3 268 5 - - HYPH cord-023865-6rafp3x3 268 6 CoV CoV NNP cord-023865-6rafp3x3 268 7 patients patient NNS cord-023865-6rafp3x3 268 8 , , , cord-023865-6rafp3x3 268 9 the the DT cord-023865-6rafp3x3 268 10 N N NNP cord-023865-6rafp3x3 268 11 - - HYPH cord-023865-6rafp3x3 268 12 protein protein NN cord-023865-6rafp3x3 268 13 has have VBZ cord-023865-6rafp3x3 268 14 been be VBN cord-023865-6rafp3x3 268 15 detected detect VBN cord-023865-6rafp3x3 268 16 as as RB cord-023865-6rafp3x3 268 17 early early RB cord-023865-6rafp3x3 268 18 as as IN cord-023865-6rafp3x3 268 19 day day NN cord-023865-6rafp3x3 268 20 one one CD cord-023865-6rafp3x3 268 21 of of IN cord-023865-6rafp3x3 268 22 infection infection NN cord-023865-6rafp3x3 268 23 by by IN cord-023865-6rafp3x3 268 24 ELISA ELISA NNP cord-023865-6rafp3x3 268 25 using use VBG cord-023865-6rafp3x3 268 26 monoclonal monoclonal JJ cord-023865-6rafp3x3 268 27 antibodies antibody NNS cord-023865-6rafp3x3 268 28 against against IN cord-023865-6rafp3x3 268 29 it -PRON- PRP cord-023865-6rafp3x3 269 1 ( ( -LRB- cord-023865-6rafp3x3 269 2 Che Che NNP cord-023865-6rafp3x3 269 3 et et FW cord-023865-6rafp3x3 269 4 al al NNP cord-023865-6rafp3x3 269 5 . . . cord-023865-6rafp3x3 269 6 2004 2004 CD cord-023865-6rafp3x3 269 7 ) ) -RRB- cord-023865-6rafp3x3 269 8 . . . cord-023865-6rafp3x3 270 1 Further further RB cord-023865-6rafp3x3 270 2 , , , cord-023865-6rafp3x3 270 3 a a DT cord-023865-6rafp3x3 270 4 comparative comparative JJ cord-023865-6rafp3x3 270 5 study study NN cord-023865-6rafp3x3 270 6 to to TO cord-023865-6rafp3x3 270 7 detect detect VB cord-023865-6rafp3x3 270 8 SARS SARS NNP cord-023865-6rafp3x3 270 9 - - HYPH cord-023865-6rafp3x3 270 10 CoV cov NN cord-023865-6rafp3x3 270 11 - - HYPH cord-023865-6rafp3x3 270 12 specific specific JJ cord-023865-6rafp3x3 270 13 IgG igg NN cord-023865-6rafp3x3 270 14 , , , cord-023865-6rafp3x3 270 15 SARS SARS NNP cord-023865-6rafp3x3 270 16 - - HYPH cord-023865-6rafp3x3 270 17 CoV CoV NNP cord-023865-6rafp3x3 270 18 RNA RNA NNP cord-023865-6rafp3x3 270 19 , , , cord-023865-6rafp3x3 270 20 and and CC cord-023865-6rafp3x3 270 21 the the DT cord-023865-6rafp3x3 270 22 N n NN cord-023865-6rafp3x3 270 23 - - HYPH cord-023865-6rafp3x3 270 24 protein protein NN cord-023865-6rafp3x3 270 25 during during IN cord-023865-6rafp3x3 270 26 early early JJ cord-023865-6rafp3x3 270 27 stages stage NNS cord-023865-6rafp3x3 270 28 of of IN cord-023865-6rafp3x3 270 29 infection infection NN cord-023865-6rafp3x3 270 30 has have VBZ cord-023865-6rafp3x3 270 31 demonstrated demonstrate VBN cord-023865-6rafp3x3 270 32 that that IN cord-023865-6rafp3x3 270 33 the the DT cord-023865-6rafp3x3 270 34 detection detection NN cord-023865-6rafp3x3 270 35 efficiency efficiency NN cord-023865-6rafp3x3 270 36 of of IN cord-023865-6rafp3x3 270 37 the the DT cord-023865-6rafp3x3 270 38 N n CD cord-023865-6rafp3x3 270 39 - - HYPH cord-023865-6rafp3x3 270 40 protein protein NN cord-023865-6rafp3x3 270 41 is be VBZ cord-023865-6rafp3x3 270 42 significantly significantly RB cord-023865-6rafp3x3 270 43 higher high JJR cord-023865-6rafp3x3 270 44 than than IN cord-023865-6rafp3x3 270 45 the the DT cord-023865-6rafp3x3 270 46 other other JJ cord-023865-6rafp3x3 270 47 two two CD cord-023865-6rafp3x3 270 48 markers marker NNS cord-023865-6rafp3x3 270 49 ( ( -LRB- cord-023865-6rafp3x3 270 50 Li Li NNP cord-023865-6rafp3x3 270 51 et et NNP cord-023865-6rafp3x3 270 52 al al NNP cord-023865-6rafp3x3 270 53 . . NNP cord-023865-6rafp3x3 270 54 2005b 2005b CD cord-023865-6rafp3x3 270 55 ) ) -RRB- cord-023865-6rafp3x3 270 56 . . . cord-023865-6rafp3x3 271 1 Researchers researcher NNS cord-023865-6rafp3x3 271 2 have have VBP cord-023865-6rafp3x3 271 3 been be VBN cord-023865-6rafp3x3 271 4 mainly mainly RB cord-023865-6rafp3x3 271 5 focussing focusse VBG cord-023865-6rafp3x3 271 6 on on IN cord-023865-6rafp3x3 271 7 two two CD cord-023865-6rafp3x3 271 8 different different JJ cord-023865-6rafp3x3 271 9 strategies strategy NNS cord-023865-6rafp3x3 271 10 by by IN cord-023865-6rafp3x3 271 11 which which WDT cord-023865-6rafp3x3 271 12 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 271 13 can can MD cord-023865-6rafp3x3 271 14 be be VB cord-023865-6rafp3x3 271 15 used use VBN cord-023865-6rafp3x3 271 16 as as IN cord-023865-6rafp3x3 271 17 a a DT cord-023865-6rafp3x3 271 18 diagnostic diagnostic JJ cord-023865-6rafp3x3 271 19 tool tool NN cord-023865-6rafp3x3 271 20 : : : cord-023865-6rafp3x3 271 21 ( ( -LRB- cord-023865-6rafp3x3 271 22 1 1 LS cord-023865-6rafp3x3 271 23 ) ) -RRB- cord-023865-6rafp3x3 271 24 development development NN cord-023865-6rafp3x3 271 25 of of IN cord-023865-6rafp3x3 271 26 efficient efficient JJ cord-023865-6rafp3x3 271 27 monoclonal monoclonal JJ cord-023865-6rafp3x3 271 28 antibodies antibody NNS cord-023865-6rafp3x3 271 29 against against IN cord-023865-6rafp3x3 271 30 the the DT cord-023865-6rafp3x3 271 31 N N NNP cord-023865-6rafp3x3 271 32 - - HYPH cord-023865-6rafp3x3 271 33 protein protein NN cord-023865-6rafp3x3 271 34 , , , cord-023865-6rafp3x3 271 35 and and CC cord-023865-6rafp3x3 271 36 ( ( -LRB- cord-023865-6rafp3x3 271 37 2 2 LS cord-023865-6rafp3x3 271 38 ) ) -RRB- cord-023865-6rafp3x3 271 39 production production NN cord-023865-6rafp3x3 271 40 of of IN cord-023865-6rafp3x3 271 41 recombinantly recombinantly RB cord-023865-6rafp3x3 271 42 expressed express VBN cord-023865-6rafp3x3 271 43 , , , cord-023865-6rafp3x3 271 44 highly highly RB cord-023865-6rafp3x3 271 45 purified purify VBN cord-023865-6rafp3x3 271 46 N n NN cord-023865-6rafp3x3 271 47 - - HYPH cord-023865-6rafp3x3 271 48 protein protein NN cord-023865-6rafp3x3 271 49 for for IN cord-023865-6rafp3x3 271 50 detection detection NN cord-023865-6rafp3x3 271 51 of of IN cord-023865-6rafp3x3 271 52 N n CD cord-023865-6rafp3x3 271 53 - - HYPH cord-023865-6rafp3x3 271 54 protein protein NN cord-023865-6rafp3x3 271 55 - - HYPH cord-023865-6rafp3x3 271 56 specific specific JJ cord-023865-6rafp3x3 271 57 antibody antibody NN cord-023865-6rafp3x3 271 58 in in IN cord-023865-6rafp3x3 271 59 the the DT cord-023865-6rafp3x3 271 60 host host NN cord-023865-6rafp3x3 271 61 . . . cord-023865-6rafp3x3 272 1 Using use VBG cord-023865-6rafp3x3 272 2 a a DT cord-023865-6rafp3x3 272 3 phage phage NN cord-023865-6rafp3x3 272 4 display display NN cord-023865-6rafp3x3 272 5 approach approach NN cord-023865-6rafp3x3 272 6 , , , cord-023865-6rafp3x3 272 7 Flego Flego NNP cord-023865-6rafp3x3 272 8 et et NNP cord-023865-6rafp3x3 272 9 al al NNP cord-023865-6rafp3x3 272 10 . . . cord-023865-6rafp3x3 273 1 ( ( -LRB- cord-023865-6rafp3x3 273 2 2005 2005 CD cord-023865-6rafp3x3 273 3 ) ) -RRB- cord-023865-6rafp3x3 273 4 have have VBP cord-023865-6rafp3x3 273 5 identified identify VBN cord-023865-6rafp3x3 273 6 human human JJ cord-023865-6rafp3x3 273 7 antibody antibody NN cord-023865-6rafp3x3 273 8 fragments fragment NNS cord-023865-6rafp3x3 273 9 that that WDT cord-023865-6rafp3x3 273 10 recognize recognize VBP cord-023865-6rafp3x3 273 11 distinct distinct JJ cord-023865-6rafp3x3 273 12 epitopes epitope NNS cord-023865-6rafp3x3 273 13 of of IN cord-023865-6rafp3x3 273 14 the the DT cord-023865-6rafp3x3 273 15 N N NNP cord-023865-6rafp3x3 273 16 - - HYPH cord-023865-6rafp3x3 273 17 protein protein NN cord-023865-6rafp3x3 273 18 . . . cord-023865-6rafp3x3 274 1 These these DT cord-023865-6rafp3x3 274 2 may may MD cord-023865-6rafp3x3 274 3 help help VB cord-023865-6rafp3x3 274 4 develop develop VB cord-023865-6rafp3x3 274 5 efficient efficient JJ cord-023865-6rafp3x3 274 6 reagents reagent NNS cord-023865-6rafp3x3 274 7 to to TO cord-023865-6rafp3x3 274 8 detect detect VB cord-023865-6rafp3x3 274 9 N n CD cord-023865-6rafp3x3 274 10 - - HYPH cord-023865-6rafp3x3 274 11 protein protein NN cord-023865-6rafp3x3 274 12 in in IN cord-023865-6rafp3x3 274 13 the the DT cord-023865-6rafp3x3 274 14 infected infected JJ cord-023865-6rafp3x3 274 15 host host NN cord-023865-6rafp3x3 274 16 . . . cord-023865-6rafp3x3 275 1 Further further RB cord-023865-6rafp3x3 275 2 , , , cord-023865-6rafp3x3 275 3 several several JJ cord-023865-6rafp3x3 275 4 laboratories laboratory NNS cord-023865-6rafp3x3 275 5 have have VBP cord-023865-6rafp3x3 275 6 been be VBN cord-023865-6rafp3x3 275 7 trying try VBG cord-023865-6rafp3x3 275 8 to to TO cord-023865-6rafp3x3 275 9 develop develop VB cord-023865-6rafp3x3 275 10 efficient efficient JJ cord-023865-6rafp3x3 275 11 monoclonal monoclonal JJ cord-023865-6rafp3x3 275 12 antibodies antibody NNS cord-023865-6rafp3x3 275 13 against against IN cord-023865-6rafp3x3 275 14 the the DT cord-023865-6rafp3x3 275 15 major major JJ cord-023865-6rafp3x3 275 16 immunodominant immunodominant JJ cord-023865-6rafp3x3 275 17 epitopes epitope NNS cord-023865-6rafp3x3 275 18 of of IN cord-023865-6rafp3x3 275 19 the the DT cord-023865-6rafp3x3 275 20 N N NNP cord-023865-6rafp3x3 275 21 - - HYPH cord-023865-6rafp3x3 275 22 protein protein NN cord-023865-6rafp3x3 275 23 , , , cord-023865-6rafp3x3 275 24 that that WDT cord-023865-6rafp3x3 275 25 can can MD cord-023865-6rafp3x3 275 26 be be VB cord-023865-6rafp3x3 275 27 used use VBN cord-023865-6rafp3x3 275 28 in in IN cord-023865-6rafp3x3 275 29 ELISA ELISA NNP cord-023865-6rafp3x3 275 30 to to TO cord-023865-6rafp3x3 275 31 detect detect VB cord-023865-6rafp3x3 275 32 SARS SARS NNP cord-023865-6rafp3x3 275 33 - - HYPH cord-023865-6rafp3x3 275 34 CoV CoV NNP cord-023865-6rafp3x3 275 35 at at IN cord-023865-6rafp3x3 275 36 an an DT cord-023865-6rafp3x3 275 37 early early JJ cord-023865-6rafp3x3 275 38 stage stage NN cord-023865-6rafp3x3 275 39 of of IN cord-023865-6rafp3x3 275 40 infection infection NN cord-023865-6rafp3x3 276 1 ( ( -LRB- cord-023865-6rafp3x3 276 2 Shang Shang NNP cord-023865-6rafp3x3 276 3 et et FW cord-023865-6rafp3x3 276 4 al al NNP cord-023865-6rafp3x3 276 5 . . . cord-023865-6rafp3x3 277 1 2005 2005 CD cord-023865-6rafp3x3 277 2 ; ; : cord-023865-6rafp3x3 277 3 Liu Liu NNP cord-023865-6rafp3x3 277 4 et et NNP cord-023865-6rafp3x3 277 5 al al NNP cord-023865-6rafp3x3 277 6 . . . cord-023865-6rafp3x3 278 1 2003 2003 CD cord-023865-6rafp3x3 278 2 ; ; : cord-023865-6rafp3x3 278 3 He -PRON- PRP cord-023865-6rafp3x3 278 4 et et FW cord-023865-6rafp3x3 278 5 al al NNP cord-023865-6rafp3x3 278 6 . . . cord-023865-6rafp3x3 279 1 2005 2005 CD cord-023865-6rafp3x3 279 2 ; ; : cord-023865-6rafp3x3 279 3 Woo Woo NNP cord-023865-6rafp3x3 279 4 et et NNP cord-023865-6rafp3x3 279 5 al al NNP cord-023865-6rafp3x3 279 6 . . NNP cord-023865-6rafp3x3 279 7 2005 2005 CD cord-023865-6rafp3x3 279 8 ) ) -RRB- cord-023865-6rafp3x3 279 9 . . . cord-023865-6rafp3x3 280 1 In in IN cord-023865-6rafp3x3 280 2 another another DT cord-023865-6rafp3x3 280 3 interesting interesting JJ cord-023865-6rafp3x3 280 4 study study NN cord-023865-6rafp3x3 280 5 , , , cord-023865-6rafp3x3 280 6 Liu Liu NNP cord-023865-6rafp3x3 280 7 et et NNP cord-023865-6rafp3x3 280 8 al al NNP cord-023865-6rafp3x3 280 9 . . . cord-023865-6rafp3x3 281 1 ( ( -LRB- cord-023865-6rafp3x3 281 2 2005 2005 CD cord-023865-6rafp3x3 281 3 ) ) -RRB- cord-023865-6rafp3x3 281 4 have have VBP cord-023865-6rafp3x3 281 5 developed develop VBN cord-023865-6rafp3x3 281 6 an an DT cord-023865-6rafp3x3 281 7 immunofluorescence immunofluorescence NN cord-023865-6rafp3x3 281 8 assay assay NN cord-023865-6rafp3x3 281 9 using use VBG cord-023865-6rafp3x3 281 10 antirabbit antirabbit NNP cord-023865-6rafp3x3 281 11 N n CD cord-023865-6rafp3x3 281 12 - - HYPH cord-023865-6rafp3x3 281 13 protein protein NN cord-023865-6rafp3x3 281 14 antibody antibody NN cord-023865-6rafp3x3 281 15 that that WDT cord-023865-6rafp3x3 281 16 can can MD cord-023865-6rafp3x3 281 17 specifically specifically RB cord-023865-6rafp3x3 281 18 detect detect VB cord-023865-6rafp3x3 281 19 N n CD cord-023865-6rafp3x3 281 20 - - HYPH cord-023865-6rafp3x3 281 21 protein protein NN cord-023865-6rafp3x3 281 22 from from IN cord-023865-6rafp3x3 281 23 throat throat NN cord-023865-6rafp3x3 281 24 wash wash NN cord-023865-6rafp3x3 281 25 samples sample NNS cord-023865-6rafp3x3 281 26 of of IN cord-023865-6rafp3x3 281 27 SARS SARS NNP cord-023865-6rafp3x3 281 28 - - HYPH cord-023865-6rafp3x3 281 29 CoV CoV NNP cord-023865-6rafp3x3 281 30 patients patient NNS cord-023865-6rafp3x3 281 31 at at IN cord-023865-6rafp3x3 281 32 day day NN cord-023865-6rafp3x3 281 33 two two CD cord-023865-6rafp3x3 281 34 of of IN cord-023865-6rafp3x3 281 35 illness illness NN cord-023865-6rafp3x3 281 36 . . . cord-023865-6rafp3x3 282 1 Several several JJ cord-023865-6rafp3x3 282 2 other other JJ cord-023865-6rafp3x3 282 3 workers worker NNS cord-023865-6rafp3x3 282 4 have have VBP cord-023865-6rafp3x3 282 5 focussed focusse VBN cord-023865-6rafp3x3 282 6 on on IN cord-023865-6rafp3x3 282 7 economical economical JJ cord-023865-6rafp3x3 282 8 production production NN cord-023865-6rafp3x3 282 9 of of IN cord-023865-6rafp3x3 282 10 highly highly RB cord-023865-6rafp3x3 282 11 purified purify VBN cord-023865-6rafp3x3 282 12 recombinant recombinant JJ cord-023865-6rafp3x3 282 13 N n NN cord-023865-6rafp3x3 282 14 - - HYPH cord-023865-6rafp3x3 282 15 protein protein NN cord-023865-6rafp3x3 282 16 using use VBG cord-023865-6rafp3x3 282 17 a a DT cord-023865-6rafp3x3 282 18 variety variety NN cord-023865-6rafp3x3 282 19 of of IN cord-023865-6rafp3x3 282 20 heterologous heterologous JJ cord-023865-6rafp3x3 282 21 expression expression NN cord-023865-6rafp3x3 282 22 systems system NNS cord-023865-6rafp3x3 282 23 that that WDT cord-023865-6rafp3x3 282 24 can can MD cord-023865-6rafp3x3 282 25 be be VB cord-023865-6rafp3x3 282 26 used use VBN cord-023865-6rafp3x3 282 27 in in IN cord-023865-6rafp3x3 282 28 ELISA ELISA NNP cord-023865-6rafp3x3 282 29 to to TO cord-023865-6rafp3x3 282 30 detect detect VB cord-023865-6rafp3x3 282 31 N n CD cord-023865-6rafp3x3 282 32 - - HYPH cord-023865-6rafp3x3 282 33 protein protein NN cord-023865-6rafp3x3 282 34 - - HYPH cord-023865-6rafp3x3 282 35 specific specific JJ cord-023865-6rafp3x3 282 36 antibody antibody NN cord-023865-6rafp3x3 282 37 in in IN cord-023865-6rafp3x3 282 38 the the DT cord-023865-6rafp3x3 282 39 patient patient JJ cord-023865-6rafp3x3 282 40 sample sample NN cord-023865-6rafp3x3 282 41 . . . cord-023865-6rafp3x3 283 1 N n NN cord-023865-6rafp3x3 283 2 - - HYPH cord-023865-6rafp3x3 283 3 protein protein NN cord-023865-6rafp3x3 283 4 has have VBZ cord-023865-6rafp3x3 283 5 been be VBN cord-023865-6rafp3x3 283 6 produced produce VBN cord-023865-6rafp3x3 283 7 in in IN cord-023865-6rafp3x3 283 8 abundant abundant JJ cord-023865-6rafp3x3 283 9 quantity quantity NN cord-023865-6rafp3x3 283 10 using use VBG cord-023865-6rafp3x3 283 11 a a DT cord-023865-6rafp3x3 283 12 codon codon NN cord-023865-6rafp3x3 283 13 - - HYPH cord-023865-6rafp3x3 283 14 optimized optimize VBN cord-023865-6rafp3x3 283 15 gene gene NN cord-023865-6rafp3x3 283 16 in in IN cord-023865-6rafp3x3 283 17 E. E. NNP cord-023865-6rafp3x3 283 18 coli coli NNS cord-023865-6rafp3x3 283 19 ( ( -LRB- cord-023865-6rafp3x3 283 20 Das Das NNP cord-023865-6rafp3x3 283 21 and and CC cord-023865-6rafp3x3 283 22 Suresh Suresh NNP cord-023865-6rafp3x3 283 23 2006 2006 CD cord-023865-6rafp3x3 283 24 ) ) -RRB- cord-023865-6rafp3x3 283 25 . . . cord-023865-6rafp3x3 284 1 Saijo saijo NN cord-023865-6rafp3x3 284 2 and and CC cord-023865-6rafp3x3 284 3 coworkers coworker NNS cord-023865-6rafp3x3 284 4 have have VBP cord-023865-6rafp3x3 284 5 successfully successfully RB cord-023865-6rafp3x3 284 6 expressed express VBN cord-023865-6rafp3x3 284 7 recombinant recombinant JJ cord-023865-6rafp3x3 284 8 N n NN cord-023865-6rafp3x3 284 9 - - HYPH cord-023865-6rafp3x3 284 10 protein protein NN cord-023865-6rafp3x3 284 11 using use VBG cord-023865-6rafp3x3 284 12 a a DT cord-023865-6rafp3x3 284 13 baculovirus baculovirus NN cord-023865-6rafp3x3 284 14 expression expression NN cord-023865-6rafp3x3 284 15 system system NN cord-023865-6rafp3x3 284 16 , , , cord-023865-6rafp3x3 284 17 which which WDT cord-023865-6rafp3x3 284 18 was be VBD cord-023865-6rafp3x3 284 19 found find VBN cord-023865-6rafp3x3 284 20 to to TO cord-023865-6rafp3x3 284 21 be be VB cord-023865-6rafp3x3 284 22 92 92 CD cord-023865-6rafp3x3 284 23 % % NN cord-023865-6rafp3x3 284 24 efficient efficient JJ cord-023865-6rafp3x3 284 25 in in IN cord-023865-6rafp3x3 284 26 neutralizing neutralize VBG cord-023865-6rafp3x3 284 27 antibody antibody NN cord-023865-6rafp3x3 284 28 assay assay NN cord-023865-6rafp3x3 284 29 ( ( -LRB- cord-023865-6rafp3x3 284 30 Saijo Saijo NNP cord-023865-6rafp3x3 284 31 et et FW cord-023865-6rafp3x3 284 32 al al NNP cord-023865-6rafp3x3 284 33 . . NNP cord-023865-6rafp3x3 284 34 2005 2005 CD cord-023865-6rafp3x3 284 35 ) ) -RRB- cord-023865-6rafp3x3 284 36 . . . cord-023865-6rafp3x3 285 1 In in IN cord-023865-6rafp3x3 285 2 another another DT cord-023865-6rafp3x3 285 3 study study NN cord-023865-6rafp3x3 285 4 , , , cord-023865-6rafp3x3 285 5 Liu Liu NNP cord-023865-6rafp3x3 285 6 et et NNP cord-023865-6rafp3x3 285 7 al al NNP cord-023865-6rafp3x3 285 8 . . NNP cord-023865-6rafp3x3 285 9 have have VBP cord-023865-6rafp3x3 285 10 expressed express VBN cord-023865-6rafp3x3 285 11 full full JJ cord-023865-6rafp3x3 285 12 length length NN cord-023865-6rafp3x3 285 13 N n NN cord-023865-6rafp3x3 285 14 - - HYPH cord-023865-6rafp3x3 285 15 protein protein NN cord-023865-6rafp3x3 285 16 using use VBG cord-023865-6rafp3x3 285 17 a a DT cord-023865-6rafp3x3 285 18 yeast yeast NN cord-023865-6rafp3x3 285 19 expression expression NN cord-023865-6rafp3x3 285 20 system system NN cord-023865-6rafp3x3 285 21 ) ) -RRB- cord-023865-6rafp3x3 285 22 . . . cord-023865-6rafp3x3 286 1 However however RB cord-023865-6rafp3x3 286 2 diagnostic diagnostic JJ cord-023865-6rafp3x3 286 3 use use NN cord-023865-6rafp3x3 286 4 of of IN cord-023865-6rafp3x3 286 5 recombinant recombinant JJ cord-023865-6rafp3x3 286 6 N n NN cord-023865-6rafp3x3 286 7 - - HYPH cord-023865-6rafp3x3 286 8 protein protein NN cord-023865-6rafp3x3 286 9 has have VBZ cord-023865-6rafp3x3 286 10 been be VBN cord-023865-6rafp3x3 286 11 a a DT cord-023865-6rafp3x3 286 12 problematic problematic JJ cord-023865-6rafp3x3 286 13 issue issue NN cord-023865-6rafp3x3 286 14 because because IN cord-023865-6rafp3x3 286 15 of of IN cord-023865-6rafp3x3 286 16 several several JJ cord-023865-6rafp3x3 286 17 reasons reason NNS cord-023865-6rafp3x3 286 18 as as IN cord-023865-6rafp3x3 286 19 discussed discuss VBN cord-023865-6rafp3x3 286 20 below below RB cord-023865-6rafp3x3 286 21 . . . cord-023865-6rafp3x3 287 1 Bacterially Bacterially NNP cord-023865-6rafp3x3 287 2 expressed express VBD cord-023865-6rafp3x3 287 3 N n CD cord-023865-6rafp3x3 287 4 - - HYPH cord-023865-6rafp3x3 287 5 protein protein NN cord-023865-6rafp3x3 287 6 has have VBZ cord-023865-6rafp3x3 287 7 been be VBN cord-023865-6rafp3x3 287 8 reported report VBN cord-023865-6rafp3x3 287 9 to to TO cord-023865-6rafp3x3 287 10 produce produce VB cord-023865-6rafp3x3 287 11 false false JJ cord-023865-6rafp3x3 287 12 seropositivity seropositivity NN cord-023865-6rafp3x3 287 13 owing owe VBG cord-023865-6rafp3x3 287 14 to to IN cord-023865-6rafp3x3 287 15 interference interference NN cord-023865-6rafp3x3 287 16 of of IN cord-023865-6rafp3x3 287 17 bacterially bacterially RB cord-023865-6rafp3x3 287 18 derived derive VBN cord-023865-6rafp3x3 287 19 antigens antigen NNS cord-023865-6rafp3x3 287 20 ( ( -LRB- cord-023865-6rafp3x3 287 21 Leung Leung NNP cord-023865-6rafp3x3 287 22 et et NNP cord-023865-6rafp3x3 287 23 al al NNP cord-023865-6rafp3x3 287 24 . . . cord-023865-6rafp3x3 288 1 2006 2006 CD cord-023865-6rafp3x3 288 2 ; ; : cord-023865-6rafp3x3 288 3 Yip Yip NNP cord-023865-6rafp3x3 288 4 et et NNP cord-023865-6rafp3x3 288 5 al al NNP cord-023865-6rafp3x3 288 6 2007 2007 CD cord-023865-6rafp3x3 288 7 ) ) -RRB- cord-023865-6rafp3x3 288 8 . . . cord-023865-6rafp3x3 289 1 In in IN cord-023865-6rafp3x3 289 2 addition addition NN cord-023865-6rafp3x3 289 3 , , , cord-023865-6rafp3x3 289 4 several several JJ cord-023865-6rafp3x3 289 5 studies study NNS cord-023865-6rafp3x3 289 6 have have VBP cord-023865-6rafp3x3 289 7 shown show VBN cord-023865-6rafp3x3 289 8 cross cross NN cord-023865-6rafp3x3 289 9 - - NN cord-023865-6rafp3x3 289 10 reactivity reactivity NN cord-023865-6rafp3x3 289 11 between between IN cord-023865-6rafp3x3 289 12 full full JJ cord-023865-6rafp3x3 289 13 - - HYPH cord-023865-6rafp3x3 289 14 length length NN cord-023865-6rafp3x3 289 15 N n CD cord-023865-6rafp3x3 289 16 - - HYPH cord-023865-6rafp3x3 289 17 protein protein NN cord-023865-6rafp3x3 289 18 of of IN cord-023865-6rafp3x3 289 19 SARS SARS NNP cord-023865-6rafp3x3 289 20 and and CC cord-023865-6rafp3x3 289 21 polyclonal polyclonal JJ cord-023865-6rafp3x3 289 22 antisera antisera NN cord-023865-6rafp3x3 289 23 of of IN cord-023865-6rafp3x3 289 24 group group NN cord-023865-6rafp3x3 289 25 1 1 CD cord-023865-6rafp3x3 289 26 animal animal NN cord-023865-6rafp3x3 289 27 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 289 28 , , , cord-023865-6rafp3x3 289 29 which which WDT cord-023865-6rafp3x3 289 30 may may MD cord-023865-6rafp3x3 289 31 lead lead VB cord-023865-6rafp3x3 289 32 to to IN cord-023865-6rafp3x3 289 33 faulty faulty JJ cord-023865-6rafp3x3 289 34 detection detection NN cord-023865-6rafp3x3 289 35 ( ( -LRB- cord-023865-6rafp3x3 289 36 Sun Sun NNP cord-023865-6rafp3x3 289 37 and and CC cord-023865-6rafp3x3 289 38 Meng Meng NNP cord-023865-6rafp3x3 289 39 2004 2004 CD cord-023865-6rafp3x3 289 40 ) ) -RRB- cord-023865-6rafp3x3 289 41 . . . cord-023865-6rafp3x3 290 1 Another another DT cord-023865-6rafp3x3 290 2 study study NN cord-023865-6rafp3x3 290 3 done do VBN cord-023865-6rafp3x3 290 4 by by IN cord-023865-6rafp3x3 290 5 Woo Woo NNP cord-023865-6rafp3x3 290 6 et et NNP cord-023865-6rafp3x3 290 7 al al NNP cord-023865-6rafp3x3 290 8 . . . cord-023865-6rafp3x3 291 1 also also RB cord-023865-6rafp3x3 291 2 reported report VBD cord-023865-6rafp3x3 291 3 cross cross NN cord-023865-6rafp3x3 291 4 - - NN cord-023865-6rafp3x3 291 5 reactivity reactivity NN cord-023865-6rafp3x3 291 6 of of IN cord-023865-6rafp3x3 291 7 full full JJ cord-023865-6rafp3x3 291 8 - - HYPH cord-023865-6rafp3x3 291 9 length length NN cord-023865-6rafp3x3 291 10 recombinant recombinant JJ cord-023865-6rafp3x3 291 11 N n NN cord-023865-6rafp3x3 291 12 - - HYPH cord-023865-6rafp3x3 291 13 protein protein NN cord-023865-6rafp3x3 291 14 with with IN cord-023865-6rafp3x3 291 15 antisera antisera NN cord-023865-6rafp3x3 291 16 of of IN cord-023865-6rafp3x3 291 17 HCoV HCoV NNP cord-023865-6rafp3x3 291 18 - - HYPH cord-023865-6rafp3x3 291 19 OC43 OC43 NNP cord-023865-6rafp3x3 291 20 and and CC cord-023865-6rafp3x3 291 21 HCoV-229E HCoV-229E NNP cord-023865-6rafp3x3 291 22 infected infect VBN cord-023865-6rafp3x3 291 23 patients patient NNS cord-023865-6rafp3x3 291 24 , , , cord-023865-6rafp3x3 291 25 thus thus RB cord-023865-6rafp3x3 291 26 giving give VBG cord-023865-6rafp3x3 291 27 false false JJ cord-023865-6rafp3x3 291 28 positive positive JJ cord-023865-6rafp3x3 291 29 results result NNS cord-023865-6rafp3x3 291 30 . . . cord-023865-6rafp3x3 292 1 They -PRON- PRP cord-023865-6rafp3x3 292 2 were be VBD cord-023865-6rafp3x3 292 3 able able JJ cord-023865-6rafp3x3 292 4 to to TO cord-023865-6rafp3x3 292 5 minimize minimize VB cord-023865-6rafp3x3 292 6 this this DT cord-023865-6rafp3x3 292 7 false false JJ cord-023865-6rafp3x3 292 8 positivity positivity NN cord-023865-6rafp3x3 292 9 by by IN cord-023865-6rafp3x3 292 10 further further RB cord-023865-6rafp3x3 292 11 verifying verify VBG cord-023865-6rafp3x3 292 12 the the DT cord-023865-6rafp3x3 292 13 ELISA ELISA NNP cord-023865-6rafp3x3 292 14 results result NNS cord-023865-6rafp3x3 292 15 with with IN cord-023865-6rafp3x3 292 16 Western western JJ cord-023865-6rafp3x3 292 17 blot blot NN cord-023865-6rafp3x3 292 18 assay assay NN cord-023865-6rafp3x3 292 19 using use VBG cord-023865-6rafp3x3 292 20 recombinant recombinant JJ cord-023865-6rafp3x3 292 21 N n NN cord-023865-6rafp3x3 292 22 and and CC cord-023865-6rafp3x3 292 23 spike spike NN cord-023865-6rafp3x3 292 24 proteins protein NNS cord-023865-6rafp3x3 292 25 of of IN cord-023865-6rafp3x3 292 26 SARS SARS NNP cord-023865-6rafp3x3 292 27 - - HYPH cord-023865-6rafp3x3 292 28 CoV CoV NNP cord-023865-6rafp3x3 292 29 ( ( -LRB- cord-023865-6rafp3x3 292 30 Woo woo UH cord-023865-6rafp3x3 292 31 et et FW cord-023865-6rafp3x3 292 32 al al NNP cord-023865-6rafp3x3 292 33 . . . cord-023865-6rafp3x3 292 34 2004 2004 CD cord-023865-6rafp3x3 292 35 ) ) -RRB- cord-023865-6rafp3x3 292 36 . . . cord-023865-6rafp3x3 293 1 Later later RB cord-023865-6rafp3x3 293 2 , , , cord-023865-6rafp3x3 293 3 studies study NNS cord-023865-6rafp3x3 293 4 done do VBN cord-023865-6rafp3x3 293 5 by by IN cord-023865-6rafp3x3 293 6 Qiu Qiu NNP cord-023865-6rafp3x3 293 7 et et FW cord-023865-6rafp3x3 293 8 al al NNP cord-023865-6rafp3x3 293 9 . . . cord-023865-6rafp3x3 293 10 and and CC cord-023865-6rafp3x3 293 11 Bussmann Bussmann NNP cord-023865-6rafp3x3 293 12 et et NNP cord-023865-6rafp3x3 293 13 al al NNP cord-023865-6rafp3x3 293 14 . . NNP cord-023865-6rafp3x3 293 15 showed show VBD cord-023865-6rafp3x3 293 16 that that IN cord-023865-6rafp3x3 293 17 the the DT cord-023865-6rafp3x3 293 18 recombinantly recombinantly RB cord-023865-6rafp3x3 293 19 expressed express VBD cord-023865-6rafp3x3 293 20 C c NN cord-023865-6rafp3x3 293 21 - - HYPH cord-023865-6rafp3x3 293 22 terminal terminal NN cord-023865-6rafp3x3 293 23 of of IN cord-023865-6rafp3x3 293 24 the the DT cord-023865-6rafp3x3 293 25 N n CD cord-023865-6rafp3x3 293 26 - - HYPH cord-023865-6rafp3x3 293 27 protein protein NN cord-023865-6rafp3x3 293 28 acts act VBZ cord-023865-6rafp3x3 293 29 more more RBR cord-023865-6rafp3x3 293 30 specifically specifically RB cord-023865-6rafp3x3 293 31 in in IN cord-023865-6rafp3x3 293 32 detecting detect VBG cord-023865-6rafp3x3 293 33 SARS SARS NNP cord-023865-6rafp3x3 293 34 - - HYPH cord-023865-6rafp3x3 293 35 CoV cov NN cord-023865-6rafp3x3 293 36 - - HYPH cord-023865-6rafp3x3 293 37 specific specific JJ cord-023865-6rafp3x3 293 38 antisera antisera NN cord-023865-6rafp3x3 293 39 in in IN cord-023865-6rafp3x3 293 40 comparison comparison NN cord-023865-6rafp3x3 293 41 to to IN cord-023865-6rafp3x3 293 42 full full JJ cord-023865-6rafp3x3 293 43 - - HYPH cord-023865-6rafp3x3 293 44 length length NN cord-023865-6rafp3x3 293 45 N n CD cord-023865-6rafp3x3 293 46 - - HYPH cord-023865-6rafp3x3 293 47 protein protein NN cord-023865-6rafp3x3 293 48 ( ( -LRB- cord-023865-6rafp3x3 293 49 Qiu Qiu NNP cord-023865-6rafp3x3 293 50 et et FW cord-023865-6rafp3x3 293 51 al al NNP cord-023865-6rafp3x3 293 52 . . NNP cord-023865-6rafp3x3 293 53 2005 2005 CD cord-023865-6rafp3x3 293 54 ; ; : cord-023865-6rafp3x3 293 55 Bussmann Bussmann NNP cord-023865-6rafp3x3 293 56 et et NNP cord-023865-6rafp3x3 293 57 al al NNP cord-023865-6rafp3x3 293 58 . . . cord-023865-6rafp3x3 293 59 2006 2006 CD cord-023865-6rafp3x3 293 60 ) ) -RRB- cord-023865-6rafp3x3 293 61 . . . cord-023865-6rafp3x3 294 1 It -PRON- PRP cord-023865-6rafp3x3 294 2 is be VBZ cord-023865-6rafp3x3 294 3 noteworthy noteworthy JJ cord-023865-6rafp3x3 294 4 that that IN cord-023865-6rafp3x3 294 5 this this DT cord-023865-6rafp3x3 294 6 region region NN cord-023865-6rafp3x3 294 7 is be VBZ cord-023865-6rafp3x3 294 8 predicted predict VBN cord-023865-6rafp3x3 294 9 to to TO cord-023865-6rafp3x3 294 10 encompass encompass VB cord-023865-6rafp3x3 294 11 major major JJ cord-023865-6rafp3x3 294 12 antigenic antigenic JJ cord-023865-6rafp3x3 294 13 sites site NNS cord-023865-6rafp3x3 294 14 of of IN cord-023865-6rafp3x3 294 15 the the DT cord-023865-6rafp3x3 294 16 N n NN cord-023865-6rafp3x3 294 17 - - HYPH cord-023865-6rafp3x3 294 18 protein protein NN cord-023865-6rafp3x3 294 19 . . . cord-023865-6rafp3x3 295 1 In in IN cord-023865-6rafp3x3 295 2 a a DT cord-023865-6rafp3x3 295 3 recent recent JJ cord-023865-6rafp3x3 295 4 report report NN cord-023865-6rafp3x3 295 5 , , , cord-023865-6rafp3x3 295 6 Shin Shin NNP cord-023865-6rafp3x3 295 7 et et NNP cord-023865-6rafp3x3 295 8 al al NNP cord-023865-6rafp3x3 295 9 . . . cord-023865-6rafp3x3 296 1 ( ( -LRB- cord-023865-6rafp3x3 296 2 2007 2007 CD cord-023865-6rafp3x3 296 3 ) ) -RRB- cord-023865-6rafp3x3 296 4 demonstrated demonstrate VBD cord-023865-6rafp3x3 296 5 significantly significantly RB cord-023865-6rafp3x3 296 6 higher high JJR cord-023865-6rafp3x3 296 7 efficacy efficacy NN cord-023865-6rafp3x3 296 8 of of IN cord-023865-6rafp3x3 296 9 phosphorylated phosphorylated JJ cord-023865-6rafp3x3 296 10 N n NN cord-023865-6rafp3x3 296 11 - - HYPH cord-023865-6rafp3x3 296 12 protein protein NN cord-023865-6rafp3x3 296 13 as as IN cord-023865-6rafp3x3 296 14 a a DT cord-023865-6rafp3x3 296 15 diagnostic diagnostic JJ cord-023865-6rafp3x3 296 16 antigen antigen NN cord-023865-6rafp3x3 296 17 . . . cord-023865-6rafp3x3 297 1 They -PRON- PRP cord-023865-6rafp3x3 297 2 expressed express VBD cord-023865-6rafp3x3 297 3 the the DT cord-023865-6rafp3x3 297 4 N n NN cord-023865-6rafp3x3 297 5 - - HYPH cord-023865-6rafp3x3 297 6 protein protein NN cord-023865-6rafp3x3 297 7 in in IN cord-023865-6rafp3x3 297 8 insect insect NN cord-023865-6rafp3x3 297 9 cells cell NNS cord-023865-6rafp3x3 297 10 , , , cord-023865-6rafp3x3 297 11 where where WRB cord-023865-6rafp3x3 297 12 it -PRON- PRP cord-023865-6rafp3x3 297 13 was be VBD cord-023865-6rafp3x3 297 14 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 297 15 by by IN cord-023865-6rafp3x3 297 16 posttranslational posttranslational JJ cord-023865-6rafp3x3 297 17 modification modification NN cord-023865-6rafp3x3 297 18 . . . cord-023865-6rafp3x3 298 1 When when WRB cord-023865-6rafp3x3 298 2 the the DT cord-023865-6rafp3x3 298 3 antigenicity antigenicity NN cord-023865-6rafp3x3 298 4 of of IN cord-023865-6rafp3x3 298 5 this this DT cord-023865-6rafp3x3 298 6 protein protein NN cord-023865-6rafp3x3 298 7 was be VBD cord-023865-6rafp3x3 298 8 compared compare VBN cord-023865-6rafp3x3 298 9 to to IN cord-023865-6rafp3x3 298 10 that that DT cord-023865-6rafp3x3 298 11 of of IN cord-023865-6rafp3x3 298 12 a a DT cord-023865-6rafp3x3 298 13 bacterially bacterially RB cord-023865-6rafp3x3 298 14 expressed express VBN cord-023865-6rafp3x3 298 15 N n NN cord-023865-6rafp3x3 298 16 - - HYPH cord-023865-6rafp3x3 298 17 protein protein NN cord-023865-6rafp3x3 298 18 ( ( -LRB- cord-023865-6rafp3x3 298 19 unphosphorylated unphosphorylated NNP cord-023865-6rafp3x3 298 20 ) ) -RRB- cord-023865-6rafp3x3 298 21 or or CC cord-023865-6rafp3x3 298 22 to to IN cord-023865-6rafp3x3 298 23 that that DT cord-023865-6rafp3x3 298 24 of of IN cord-023865-6rafp3x3 298 25 a a DT cord-023865-6rafp3x3 298 26 dephosphorylated dephosphorylated JJ cord-023865-6rafp3x3 298 27 N n NN cord-023865-6rafp3x3 298 28 - - HYPH cord-023865-6rafp3x3 298 29 protein protein NN cord-023865-6rafp3x3 298 30 ( ( -LRB- cord-023865-6rafp3x3 298 31 by by IN cord-023865-6rafp3x3 298 32 treatment treatment NN cord-023865-6rafp3x3 298 33 with with IN cord-023865-6rafp3x3 298 34 protein protein NN cord-023865-6rafp3x3 298 35 phosphatase phosphatase NN cord-023865-6rafp3x3 298 36 1 1 CD cord-023865-6rafp3x3 298 37 ) ) -RRB- cord-023865-6rafp3x3 298 38 using use VBG cord-023865-6rafp3x3 298 39 SARS SARS NNP cord-023865-6rafp3x3 298 40 - - HYPH cord-023865-6rafp3x3 298 41 positive positive JJ cord-023865-6rafp3x3 298 42 or or CC cord-023865-6rafp3x3 298 43 -negative -negative JJ cord-023865-6rafp3x3 299 1 patient patient NNP cord-023865-6rafp3x3 299 2 serum serum NN cord-023865-6rafp3x3 299 3 , , , cord-023865-6rafp3x3 299 4 phosphorylated phosphorylated JJ cord-023865-6rafp3x3 299 5 N N NNP cord-023865-6rafp3x3 299 6 - - HYPH cord-023865-6rafp3x3 299 7 protein protein NN cord-023865-6rafp3x3 299 8 did do VBD cord-023865-6rafp3x3 299 9 not not RB cord-023865-6rafp3x3 299 10 show show VB cord-023865-6rafp3x3 299 11 any any DT cord-023865-6rafp3x3 299 12 cross cross NN cord-023865-6rafp3x3 299 13 - - NN cord-023865-6rafp3x3 299 14 reactivity reactivity NN cord-023865-6rafp3x3 299 15 with with IN cord-023865-6rafp3x3 299 16 SARS SARS NNP cord-023865-6rafp3x3 299 17 - - HYPH cord-023865-6rafp3x3 299 18 negative negative JJ cord-023865-6rafp3x3 299 19 serum serum NN cord-023865-6rafp3x3 299 20 , , , cord-023865-6rafp3x3 299 21 thereby thereby RB cord-023865-6rafp3x3 299 22 reducing reduce VBG cord-023865-6rafp3x3 299 23 the the DT cord-023865-6rafp3x3 299 24 number number NN cord-023865-6rafp3x3 299 25 of of IN cord-023865-6rafp3x3 299 26 false false JJ cord-023865-6rafp3x3 299 27 positives positive NNS cord-023865-6rafp3x3 299 28 . . . cord-023865-6rafp3x3 300 1 Also also RB cord-023865-6rafp3x3 300 2 , , , cord-023865-6rafp3x3 300 3 the the DT cord-023865-6rafp3x3 300 4 phosphorylated phosphorylated JJ cord-023865-6rafp3x3 300 5 protein protein NN cord-023865-6rafp3x3 300 6 showed show VBD cord-023865-6rafp3x3 300 7 considerably considerably RB cord-023865-6rafp3x3 300 8 stronger strong JJR cord-023865-6rafp3x3 300 9 cross cross NN cord-023865-6rafp3x3 300 10 - - NN cord-023865-6rafp3x3 300 11 reactivity reactivity NN cord-023865-6rafp3x3 300 12 with with IN cord-023865-6rafp3x3 300 13 an an DT cord-023865-6rafp3x3 300 14 N n CD cord-023865-6rafp3x3 300 15 - - HYPH cord-023865-6rafp3x3 300 16 protein protein NN cord-023865-6rafp3x3 300 17 - - HYPH cord-023865-6rafp3x3 300 18 specific specific JJ cord-023865-6rafp3x3 300 19 monoclonal monoclonal JJ cord-023865-6rafp3x3 300 20 antibody antibody NN cord-023865-6rafp3x3 300 21 . . . cord-023865-6rafp3x3 301 1 Based base VBN cord-023865-6rafp3x3 301 2 on on IN cord-023865-6rafp3x3 301 3 these these DT cord-023865-6rafp3x3 301 4 observations observation NNS cord-023865-6rafp3x3 301 5 , , , cord-023865-6rafp3x3 301 6 the the DT cord-023865-6rafp3x3 301 7 authors author NNS cord-023865-6rafp3x3 301 8 have have VBP cord-023865-6rafp3x3 301 9 proposed propose VBN cord-023865-6rafp3x3 301 10 the the DT cord-023865-6rafp3x3 301 11 use use NN cord-023865-6rafp3x3 301 12 of of IN cord-023865-6rafp3x3 301 13 a a DT cord-023865-6rafp3x3 301 14 phosphorylated phosphorylated JJ cord-023865-6rafp3x3 301 15 N n NN cord-023865-6rafp3x3 301 16 - - HYPH cord-023865-6rafp3x3 301 17 protein protein NN cord-023865-6rafp3x3 301 18 as as IN cord-023865-6rafp3x3 301 19 a a DT cord-023865-6rafp3x3 301 20 better well RBR cord-023865-6rafp3x3 301 21 diagnostic diagnostic JJ cord-023865-6rafp3x3 301 22 agent agent NN cord-023865-6rafp3x3 301 23 . . . cord-023865-6rafp3x3 302 1 Also also RB cord-023865-6rafp3x3 302 2 , , , cord-023865-6rafp3x3 302 3 several several JJ cord-023865-6rafp3x3 302 4 reports report NNS cord-023865-6rafp3x3 302 5 have have VBP cord-023865-6rafp3x3 302 6 been be VBN cord-023865-6rafp3x3 302 7 published publish VBN cord-023865-6rafp3x3 302 8 dealing deal VBG cord-023865-6rafp3x3 302 9 with with IN cord-023865-6rafp3x3 302 10 the the DT cord-023865-6rafp3x3 302 11 detection detection NN cord-023865-6rafp3x3 302 12 of of IN cord-023865-6rafp3x3 302 13 N n CD cord-023865-6rafp3x3 302 14 - - HYPH cord-023865-6rafp3x3 302 15 protein protein NN cord-023865-6rafp3x3 302 16 - - HYPH cord-023865-6rafp3x3 302 17 specific specific JJ cord-023865-6rafp3x3 302 18 IgM igm NN cord-023865-6rafp3x3 302 19 by by IN cord-023865-6rafp3x3 302 20 ELISA ELISA NNP cord-023865-6rafp3x3 302 21 or or CC cord-023865-6rafp3x3 302 22 indirect indirect JJ cord-023865-6rafp3x3 302 23 immunofluorescent immunofluorescent NN cord-023865-6rafp3x3 302 24 assay assay NN cord-023865-6rafp3x3 303 1 ( ( -LRB- cord-023865-6rafp3x3 303 2 Chang Chang NNP cord-023865-6rafp3x3 303 3 et et NNP cord-023865-6rafp3x3 303 4 al al NNP cord-023865-6rafp3x3 303 5 . . . cord-023865-6rafp3x3 304 1 2004 2004 CD cord-023865-6rafp3x3 304 2 ; ; : cord-023865-6rafp3x3 304 3 Hsueh Hsueh NNP cord-023865-6rafp3x3 304 4 et et NNP cord-023865-6rafp3x3 304 5 al al NNP cord-023865-6rafp3x3 304 6 . . . cord-023865-6rafp3x3 305 1 2004 2004 CD cord-023865-6rafp3x3 305 2 ; ; : cord-023865-6rafp3x3 305 3 Woo Woo NNP cord-023865-6rafp3x3 305 4 et et NNP cord-023865-6rafp3x3 305 5 al al NNP cord-023865-6rafp3x3 305 6 . . . cord-023865-6rafp3x3 305 7 2004 2004 CD cord-023865-6rafp3x3 305 8 ) ) -RRB- cord-023865-6rafp3x3 305 9 . . . cord-023865-6rafp3x3 306 1 However however RB cord-023865-6rafp3x3 306 2 , , , cord-023865-6rafp3x3 306 3 in in IN cord-023865-6rafp3x3 306 4 these these DT cord-023865-6rafp3x3 306 5 studies study NNS cord-023865-6rafp3x3 306 6 , , , cord-023865-6rafp3x3 306 7 IgM IgM NNP cord-023865-6rafp3x3 306 8 antibodies antibody NNS cord-023865-6rafp3x3 306 9 became become VBD cord-023865-6rafp3x3 306 10 detectable detectable JJ cord-023865-6rafp3x3 306 11 later later RB cord-023865-6rafp3x3 306 12 than than IN cord-023865-6rafp3x3 306 13 IgG IgG NNP cord-023865-6rafp3x3 306 14 antibodies antibody NNS cord-023865-6rafp3x3 306 15 , , , cord-023865-6rafp3x3 306 16 which which WDT cord-023865-6rafp3x3 306 17 is be VBZ cord-023865-6rafp3x3 306 18 in in IN cord-023865-6rafp3x3 306 19 contrast contrast NN cord-023865-6rafp3x3 306 20 to to IN cord-023865-6rafp3x3 306 21 the the DT cord-023865-6rafp3x3 306 22 phenomena phenomenon NNS cord-023865-6rafp3x3 306 23 observed observe VBN cord-023865-6rafp3x3 306 24 in in IN cord-023865-6rafp3x3 306 25 most most JJS cord-023865-6rafp3x3 306 26 other other JJ cord-023865-6rafp3x3 306 27 pathogens pathogen NNS cord-023865-6rafp3x3 306 28 . . . cord-023865-6rafp3x3 307 1 A a DT cord-023865-6rafp3x3 307 2 recent recent JJ cord-023865-6rafp3x3 307 3 report report NN cord-023865-6rafp3x3 307 4 published publish VBN cord-023865-6rafp3x3 307 5 by by IN cord-023865-6rafp3x3 307 6 Yu Yu NNP cord-023865-6rafp3x3 307 7 et et FW cord-023865-6rafp3x3 307 8 al al NNP cord-023865-6rafp3x3 307 9 . . . cord-023865-6rafp3x3 308 1 ( ( -LRB- cord-023865-6rafp3x3 308 2 2007 2007 CD cord-023865-6rafp3x3 308 3 ) ) -RRB- cord-023865-6rafp3x3 308 4 attempted attempt VBD cord-023865-6rafp3x3 308 5 to to TO cord-023865-6rafp3x3 308 6 solve solve VB cord-023865-6rafp3x3 308 7 this this DT cord-023865-6rafp3x3 308 8 problem problem NN cord-023865-6rafp3x3 308 9 by by IN cord-023865-6rafp3x3 308 10 using use VBG cord-023865-6rafp3x3 308 11 a a DT cord-023865-6rafp3x3 308 12 truncated truncated JJ cord-023865-6rafp3x3 308 13 N n NN cord-023865-6rafp3x3 308 14 - - HYPH cord-023865-6rafp3x3 308 15 protein protein NN cord-023865-6rafp3x3 308 16 ( ( -LRB- cord-023865-6rafp3x3 308 17 aa aa NNP cord-023865-6rafp3x3 308 18 122 122 CD cord-023865-6rafp3x3 308 19 - - HYPH cord-023865-6rafp3x3 308 20 422 422 CD cord-023865-6rafp3x3 308 21 ) ) -RRB- cord-023865-6rafp3x3 308 22 as as IN cord-023865-6rafp3x3 308 23 an an DT cord-023865-6rafp3x3 308 24 antigen antigen NN cord-023865-6rafp3x3 308 25 in in IN cord-023865-6rafp3x3 308 26 IgM IgM NNP cord-023865-6rafp3x3 308 27 ELISA ELISA NNP cord-023865-6rafp3x3 308 28 . . . cord-023865-6rafp3x3 309 1 They -PRON- PRP cord-023865-6rafp3x3 309 2 found find VBD cord-023865-6rafp3x3 309 3 the the DT cord-023865-6rafp3x3 309 4 IgM IgM NNP cord-023865-6rafp3x3 309 5 response response NN cord-023865-6rafp3x3 309 6 appeared appear VBD cord-023865-6rafp3x3 309 7 three three CD cord-023865-6rafp3x3 309 8 days day NNS cord-023865-6rafp3x3 309 9 before before IN cord-023865-6rafp3x3 309 10 detection detection NN cord-023865-6rafp3x3 309 11 of of IN cord-023865-6rafp3x3 309 12 the the DT cord-023865-6rafp3x3 309 13 IgG IgG NNP cord-023865-6rafp3x3 309 14 response response NN cord-023865-6rafp3x3 309 15 , , , cord-023865-6rafp3x3 309 16 which which WDT cord-023865-6rafp3x3 309 17 is be VBZ cord-023865-6rafp3x3 309 18 in in IN cord-023865-6rafp3x3 309 19 agreement agreement NN cord-023865-6rafp3x3 309 20 with with IN cord-023865-6rafp3x3 309 21 the the DT cord-023865-6rafp3x3 309 22 results result NNS cord-023865-6rafp3x3 309 23 obtained obtain VBN cord-023865-6rafp3x3 309 24 from from IN cord-023865-6rafp3x3 309 25 other other JJ cord-023865-6rafp3x3 309 26 known know VBN cord-023865-6rafp3x3 309 27 pathogens pathogen NNS cord-023865-6rafp3x3 309 28 . . . cord-023865-6rafp3x3 310 1 Further further RB cord-023865-6rafp3x3 310 2 , , , cord-023865-6rafp3x3 310 3 their -PRON- PRP$ cord-023865-6rafp3x3 310 4 results result NNS cord-023865-6rafp3x3 310 5 showed show VBD cord-023865-6rafp3x3 310 6 100 100 CD cord-023865-6rafp3x3 310 7 % % NN cord-023865-6rafp3x3 310 8 specificity specificity NN cord-023865-6rafp3x3 310 9 and and CC cord-023865-6rafp3x3 310 10 sensitivity sensitivity NN cord-023865-6rafp3x3 310 11 of of IN cord-023865-6rafp3x3 310 12 the the DT cord-023865-6rafp3x3 310 13 truncated truncated JJ cord-023865-6rafp3x3 310 14 protein protein NN cord-023865-6rafp3x3 310 15 in in IN cord-023865-6rafp3x3 310 16 detecting detect VBG cord-023865-6rafp3x3 310 17 N n CD cord-023865-6rafp3x3 310 18 - - HYPH cord-023865-6rafp3x3 310 19 protein protein NN cord-023865-6rafp3x3 310 20 - - HYPH cord-023865-6rafp3x3 310 21 specific specific JJ cord-023865-6rafp3x3 310 22 IgM igm NN cord-023865-6rafp3x3 310 23 from from IN cord-023865-6rafp3x3 310 24 patients patient NNS cord-023865-6rafp3x3 310 25 with with IN cord-023865-6rafp3x3 310 26 laboratory laboratory NN cord-023865-6rafp3x3 310 27 confirmed confirm VBD cord-023865-6rafp3x3 310 28 SARS SARS NNP cord-023865-6rafp3x3 310 29 cases case NNS cord-023865-6rafp3x3 310 30 in in IN cord-023865-6rafp3x3 310 31 comparison comparison NN cord-023865-6rafp3x3 310 32 to to IN cord-023865-6rafp3x3 310 33 healthy healthy JJ cord-023865-6rafp3x3 310 34 volunteers volunteer NNS cord-023865-6rafp3x3 310 35 . . . cord-023865-6rafp3x3 311 1 The the DT cord-023865-6rafp3x3 311 2 authors author NNS cord-023865-6rafp3x3 311 3 have have VBP cord-023865-6rafp3x3 311 4 suggested suggest VBN cord-023865-6rafp3x3 311 5 that that IN cord-023865-6rafp3x3 311 6 the the DT cord-023865-6rafp3x3 311 7 IgM IgM NNP cord-023865-6rafp3x3 311 8 capture capture NN cord-023865-6rafp3x3 311 9 ELISA ELISA NNP cord-023865-6rafp3x3 311 10 using use VBG cord-023865-6rafp3x3 311 11 this this DT cord-023865-6rafp3x3 311 12 truncated truncated JJ cord-023865-6rafp3x3 311 13 N n NN cord-023865-6rafp3x3 311 14 - - HYPH cord-023865-6rafp3x3 311 15 protein protein NN cord-023865-6rafp3x3 311 16 may may MD cord-023865-6rafp3x3 311 17 be be VB cord-023865-6rafp3x3 311 18 more more RBR cord-023865-6rafp3x3 311 19 effective effective JJ cord-023865-6rafp3x3 311 20 in in IN cord-023865-6rafp3x3 311 21 serodiagnosis serodiagnosis NNP cord-023865-6rafp3x3 311 22 of of IN cord-023865-6rafp3x3 311 23 SARS SARS NNP cord-023865-6rafp3x3 311 24 - - HYPH cord-023865-6rafp3x3 311 25 CoV CoV NNP cord-023865-6rafp3x3 311 26 at at IN cord-023865-6rafp3x3 311 27 an an DT cord-023865-6rafp3x3 311 28 earlier early JJR cord-023865-6rafp3x3 311 29 time time NN cord-023865-6rafp3x3 311 30 . . . cord-023865-6rafp3x3 312 1 In in IN cord-023865-6rafp3x3 312 2 another another DT cord-023865-6rafp3x3 312 3 interesting interesting JJ cord-023865-6rafp3x3 312 4 report report NN cord-023865-6rafp3x3 312 5 , , , cord-023865-6rafp3x3 312 6 Woo Woo NNP cord-023865-6rafp3x3 312 7 et et NNP cord-023865-6rafp3x3 312 8 al al NNP cord-023865-6rafp3x3 312 9 . . . cord-023865-6rafp3x3 313 1 ( ( -LRB- cord-023865-6rafp3x3 313 2 2005 2005 CD cord-023865-6rafp3x3 313 3 ) ) -RRB- cord-023865-6rafp3x3 313 4 carried carry VBD cord-023865-6rafp3x3 313 5 out out RP cord-023865-6rafp3x3 313 6 comparative comparative JJ cord-023865-6rafp3x3 313 7 studies study NNS cord-023865-6rafp3x3 313 8 to to TO cord-023865-6rafp3x3 313 9 evaluate evaluate VB cord-023865-6rafp3x3 313 10 the the DT cord-023865-6rafp3x3 313 11 relative relative JJ cord-023865-6rafp3x3 313 12 diagnostic diagnostic JJ cord-023865-6rafp3x3 313 13 efficacy efficacy NN cord-023865-6rafp3x3 313 14 of of IN cord-023865-6rafp3x3 313 15 recombinantly recombinantly RB cord-023865-6rafp3x3 313 16 expressed express VBD cord-023865-6rafp3x3 313 17 N N NNP cord-023865-6rafp3x3 313 18 and and CC cord-023865-6rafp3x3 313 19 Spike Spike NNP cord-023865-6rafp3x3 313 20 proteins protein NNS cord-023865-6rafp3x3 313 21 . . . cord-023865-6rafp3x3 314 1 They -PRON- PRP cord-023865-6rafp3x3 314 2 observed observe VBD cord-023865-6rafp3x3 314 3 sensitivity sensitivity NN cord-023865-6rafp3x3 314 4 of of IN cord-023865-6rafp3x3 314 5 recombinant recombinant JJ cord-023865-6rafp3x3 314 6 N N NNP cord-023865-6rafp3x3 314 7 - - HYPH cord-023865-6rafp3x3 314 8 IgG IgG NNP cord-023865-6rafp3x3 314 9 ELISA ELISA NNP cord-023865-6rafp3x3 314 10 to to TO cord-023865-6rafp3x3 314 11 be be VB cord-023865-6rafp3x3 314 12 significantly significantly RB cord-023865-6rafp3x3 314 13 higher high JJR cord-023865-6rafp3x3 314 14 than than IN cord-023865-6rafp3x3 314 15 that that DT cord-023865-6rafp3x3 314 16 of of IN cord-023865-6rafp3x3 314 17 recombinant recombinant JJ cord-023865-6rafp3x3 314 18 S S NNP cord-023865-6rafp3x3 314 19 - - HYPH cord-023865-6rafp3x3 314 20 IgG IgG NNP cord-023865-6rafp3x3 314 21 ELISA ELISA NNP cord-023865-6rafp3x3 314 22 . . . cord-023865-6rafp3x3 315 1 The the DT cord-023865-6rafp3x3 315 2 reverse reverse NN cord-023865-6rafp3x3 315 3 was be VBD cord-023865-6rafp3x3 315 4 true true JJ cord-023865-6rafp3x3 315 5 in in IN cord-023865-6rafp3x3 315 6 the the DT cord-023865-6rafp3x3 315 7 case case NN cord-023865-6rafp3x3 315 8 of of IN cord-023865-6rafp3x3 315 9 IgM IgM NNP cord-023865-6rafp3x3 315 10 ELISA ELISA NNP cord-023865-6rafp3x3 315 11 using use VBG cord-023865-6rafp3x3 315 12 recombinant recombinant JJ cord-023865-6rafp3x3 315 13 N N NNP cord-023865-6rafp3x3 315 14 and and CC cord-023865-6rafp3x3 315 15 S S NNP cord-023865-6rafp3x3 315 16 proteins protein NNS cord-023865-6rafp3x3 315 17 . . . cord-023865-6rafp3x3 316 1 Based base VBN cord-023865-6rafp3x3 316 2 on on IN cord-023865-6rafp3x3 316 3 this this DT cord-023865-6rafp3x3 316 4 data data NN cord-023865-6rafp3x3 316 5 , , , cord-023865-6rafp3x3 316 6 they -PRON- PRP cord-023865-6rafp3x3 316 7 have have VBP cord-023865-6rafp3x3 316 8 suggested suggest VBN cord-023865-6rafp3x3 316 9 the the DT cord-023865-6rafp3x3 316 10 practise practise NN cord-023865-6rafp3x3 316 11 of of IN cord-023865-6rafp3x3 316 12 ELISA ELISA NNP cord-023865-6rafp3x3 316 13 for for IN cord-023865-6rafp3x3 316 14 detection detection NN cord-023865-6rafp3x3 316 15 of of IN cord-023865-6rafp3x3 316 16 IgM IgM NNP cord-023865-6rafp3x3 316 17 against against IN cord-023865-6rafp3x3 316 18 both both DT cord-023865-6rafp3x3 316 19 S S NNP cord-023865-6rafp3x3 316 20 and and CC cord-023865-6rafp3x3 316 21 N n CD cord-023865-6rafp3x3 316 22 proteins protein NNS cord-023865-6rafp3x3 316 23 instead instead RB cord-023865-6rafp3x3 316 24 of of IN cord-023865-6rafp3x3 316 25 N n CD cord-023865-6rafp3x3 316 26 alone alone RB cord-023865-6rafp3x3 317 1 ( ( -LRB- cord-023865-6rafp3x3 317 2 Woo woo UH cord-023865-6rafp3x3 317 3 et et NNP cord-023865-6rafp3x3 317 4 al al NNP cord-023865-6rafp3x3 317 5 . . NNP cord-023865-6rafp3x3 317 6 2005 2005 CD cord-023865-6rafp3x3 317 7 ) ) -RRB- cord-023865-6rafp3x3 317 8 . . . cord-023865-6rafp3x3 318 1 Taken take VBN cord-023865-6rafp3x3 318 2 together together RB cord-023865-6rafp3x3 318 3 , , , cord-023865-6rafp3x3 318 4 all all PDT cord-023865-6rafp3x3 318 5 this this DT cord-023865-6rafp3x3 318 6 data data NN cord-023865-6rafp3x3 318 7 does do VBZ cord-023865-6rafp3x3 318 8 support support VB cord-023865-6rafp3x3 318 9 the the DT cord-023865-6rafp3x3 318 10 notion notion NN cord-023865-6rafp3x3 318 11 that that IN cord-023865-6rafp3x3 318 12 the the DT cord-023865-6rafp3x3 318 13 N N NNP cord-023865-6rafp3x3 318 14 - - HYPH cord-023865-6rafp3x3 318 15 protein protein NN cord-023865-6rafp3x3 318 16 may may MD cord-023865-6rafp3x3 318 17 be be VB cord-023865-6rafp3x3 318 18 used use VBN cord-023865-6rafp3x3 318 19 as as IN cord-023865-6rafp3x3 318 20 an an DT cord-023865-6rafp3x3 318 21 efficient efficient JJ cord-023865-6rafp3x3 318 22 diagnostic diagnostic JJ cord-023865-6rafp3x3 318 23 tool tool NN cord-023865-6rafp3x3 318 24 for for IN cord-023865-6rafp3x3 318 25 detection detection NN cord-023865-6rafp3x3 318 26 of of IN cord-023865-6rafp3x3 318 27 SARS SARS NNP cord-023865-6rafp3x3 318 28 - - HYPH cord-023865-6rafp3x3 318 29 CoV CoV NNP cord-023865-6rafp3x3 318 30 infection infection NN cord-023865-6rafp3x3 318 31 . . . cord-023865-6rafp3x3 319 1 Nevertheless nevertheless RB cord-023865-6rafp3x3 319 2 , , , cord-023865-6rafp3x3 319 3 production production NN cord-023865-6rafp3x3 319 4 scale scale NN cord-023865-6rafp3x3 319 5 - - HYPH cord-023865-6rafp3x3 319 6 up up NN cord-023865-6rafp3x3 319 7 and and CC cord-023865-6rafp3x3 319 8 further further JJ cord-023865-6rafp3x3 319 9 validation validation NN cord-023865-6rafp3x3 319 10 of of IN cord-023865-6rafp3x3 319 11 specificity specificity NN cord-023865-6rafp3x3 319 12 using use VBG cord-023865-6rafp3x3 319 13 patient patient NN cord-023865-6rafp3x3 319 14 samples sample NNS cord-023865-6rafp3x3 319 15 will will MD cord-023865-6rafp3x3 319 16 determine determine VB cord-023865-6rafp3x3 319 17 the the DT cord-023865-6rafp3x3 319 18 possible possible JJ cord-023865-6rafp3x3 319 19 clinical clinical JJ cord-023865-6rafp3x3 319 20 use use NN cord-023865-6rafp3x3 319 21 of of IN cord-023865-6rafp3x3 319 22 these these DT cord-023865-6rafp3x3 319 23 reagents reagent NNS cord-023865-6rafp3x3 319 24 . . . cord-023865-6rafp3x3 320 1 One one CD cord-023865-6rafp3x3 320 2 of of IN cord-023865-6rafp3x3 320 3 the the DT cord-023865-6rafp3x3 320 4 most most RBS cord-023865-6rafp3x3 320 5 clinically clinically RB cord-023865-6rafp3x3 320 6 relevant relevant JJ cord-023865-6rafp3x3 320 7 uses use NNS cord-023865-6rafp3x3 320 8 of of IN cord-023865-6rafp3x3 320 9 the the DT cord-023865-6rafp3x3 320 10 N n NN cord-023865-6rafp3x3 320 11 - - HYPH cord-023865-6rafp3x3 320 12 protein protein NN cord-023865-6rafp3x3 320 13 can can MD cord-023865-6rafp3x3 320 14 be be VB cord-023865-6rafp3x3 320 15 its -PRON- PRP$ cord-023865-6rafp3x3 320 16 use use NN cord-023865-6rafp3x3 320 17 as as IN cord-023865-6rafp3x3 320 18 a a DT cord-023865-6rafp3x3 320 19 protective protective JJ cord-023865-6rafp3x3 320 20 vaccine vaccine NN cord-023865-6rafp3x3 320 21 against against IN cord-023865-6rafp3x3 320 22 SARS SARS NNP cord-023865-6rafp3x3 320 23 - - HYPH cord-023865-6rafp3x3 320 24 CoV CoV NNP cord-023865-6rafp3x3 320 25 infection infection NN cord-023865-6rafp3x3 320 26 . . . cord-023865-6rafp3x3 321 1 N n NN cord-023865-6rafp3x3 321 2 - - HYPH cord-023865-6rafp3x3 321 3 protein protein NN cord-023865-6rafp3x3 321 4 is be VBZ cord-023865-6rafp3x3 321 5 one one CD cord-023865-6rafp3x3 321 6 of of IN cord-023865-6rafp3x3 321 7 the the DT cord-023865-6rafp3x3 321 8 major major JJ cord-023865-6rafp3x3 321 9 antigens antigen NNS cord-023865-6rafp3x3 321 10 of of IN cord-023865-6rafp3x3 321 11 the the DT cord-023865-6rafp3x3 321 12 SARS SARS NNP cord-023865-6rafp3x3 321 13 - - HYPH cord-023865-6rafp3x3 321 14 CoV. CoV. NNP cord-023865-6rafp3x3 322 1 Also also RB cord-023865-6rafp3x3 322 2 , , , cord-023865-6rafp3x3 322 3 N n CD cord-023865-6rafp3x3 322 4 - - HYPH cord-023865-6rafp3x3 322 5 protein protein NN cord-023865-6rafp3x3 322 6 analyzed analyze VBD cord-023865-6rafp3x3 322 7 from from IN cord-023865-6rafp3x3 322 8 different different JJ cord-023865-6rafp3x3 322 9 patient patient NN cord-023865-6rafp3x3 322 10 samples sample NNS cord-023865-6rafp3x3 322 11 shows show VBZ cord-023865-6rafp3x3 322 12 least least JJS cord-023865-6rafp3x3 322 13 variation variation NN cord-023865-6rafp3x3 322 14 in in IN cord-023865-6rafp3x3 322 15 the the DT cord-023865-6rafp3x3 322 16 gene gene NN cord-023865-6rafp3x3 322 17 sequence sequence NN cord-023865-6rafp3x3 323 1 ( ( -LRB- cord-023865-6rafp3x3 323 2 Tong Tong NNP cord-023865-6rafp3x3 323 3 et et NNP cord-023865-6rafp3x3 323 4 al al NNP cord-023865-6rafp3x3 323 5 . . . cord-023865-6rafp3x3 323 6 2004 2004 CD cord-023865-6rafp3x3 323 7 ) ) -RRB- cord-023865-6rafp3x3 323 8 , , , cord-023865-6rafp3x3 323 9 therefore therefore RB cord-023865-6rafp3x3 323 10 indicating indicate VBG cord-023865-6rafp3x3 323 11 it -PRON- PRP cord-023865-6rafp3x3 323 12 to to TO cord-023865-6rafp3x3 323 13 be be VB cord-023865-6rafp3x3 323 14 a a DT cord-023865-6rafp3x3 323 15 stable stable JJ cord-023865-6rafp3x3 323 16 protein protein NN cord-023865-6rafp3x3 323 17 , , , cord-023865-6rafp3x3 323 18 which which WDT cord-023865-6rafp3x3 323 19 is be VBZ cord-023865-6rafp3x3 323 20 a a DT cord-023865-6rafp3x3 323 21 primary primary JJ cord-023865-6rafp3x3 323 22 requirement requirement NN cord-023865-6rafp3x3 323 23 for for IN cord-023865-6rafp3x3 323 24 an an DT cord-023865-6rafp3x3 323 25 efficient efficient JJ cord-023865-6rafp3x3 323 26 vaccine vaccine NN cord-023865-6rafp3x3 323 27 candidate candidate NN cord-023865-6rafp3x3 323 28 . . . cord-023865-6rafp3x3 324 1 Earlier early JJR cord-023865-6rafp3x3 324 2 studies study NNS cord-023865-6rafp3x3 324 3 carried carry VBN cord-023865-6rafp3x3 324 4 in in IN cord-023865-6rafp3x3 324 5 Collins Collins NNP cord-023865-6rafp3x3 324 6 ' ' POS cord-023865-6rafp3x3 324 7 , , , cord-023865-6rafp3x3 324 8 Rao Rao NNP cord-023865-6rafp3x3 324 9 's 's POS cord-023865-6rafp3x3 324 10 , , , cord-023865-6rafp3x3 324 11 and and CC cord-023865-6rafp3x3 324 12 Li Li NNP cord-023865-6rafp3x3 324 13 's 's POS cord-023865-6rafp3x3 324 14 laboratories laboratory NNS cord-023865-6rafp3x3 324 15 have have VBP cord-023865-6rafp3x3 324 16 clearly clearly RB cord-023865-6rafp3x3 324 17 shown show VBN cord-023865-6rafp3x3 324 18 that that DT cord-023865-6rafp3x3 324 19 antiserum antiserum NN cord-023865-6rafp3x3 324 20 to to IN cord-023865-6rafp3x3 324 21 the the DT cord-023865-6rafp3x3 324 22 N N NNP cord-023865-6rafp3x3 324 23 - - HYPH cord-023865-6rafp3x3 324 24 protein protein NN cord-023865-6rafp3x3 324 25 does do VBZ cord-023865-6rafp3x3 324 26 not not RB cord-023865-6rafp3x3 324 27 contain contain VB cord-023865-6rafp3x3 324 28 neutralizing neutralize VBG cord-023865-6rafp3x3 324 29 antibodies antibody NNS cord-023865-6rafp3x3 324 30 against against IN cord-023865-6rafp3x3 324 31 SARS SARS NNP cord-023865-6rafp3x3 324 32 - - HYPH cord-023865-6rafp3x3 324 33 CoV CoV NNP cord-023865-6rafp3x3 324 34 ( ( -LRB- cord-023865-6rafp3x3 324 35 Buchholz Buchholz NNP cord-023865-6rafp3x3 324 36 et et NNP cord-023865-6rafp3x3 324 37 al al NNP cord-023865-6rafp3x3 324 38 . . . cord-023865-6rafp3x3 324 39 2004 2004 CD cord-023865-6rafp3x3 324 40 ; ; : cord-023865-6rafp3x3 324 41 Pang Pang NNP cord-023865-6rafp3x3 324 42 et et NNP cord-023865-6rafp3x3 324 43 al al NNP cord-023865-6rafp3x3 324 44 . . . cord-023865-6rafp3x3 324 45 2004 2004 CD cord-023865-6rafp3x3 324 46 ; ; : cord-023865-6rafp3x3 324 47 Liang Liang NNP cord-023865-6rafp3x3 324 48 et et NNP cord-023865-6rafp3x3 324 49 al al NNP cord-023865-6rafp3x3 324 50 . . NNP cord-023865-6rafp3x3 324 51 2005 2005 CD cord-023865-6rafp3x3 324 52 ) ) -RRB- cord-023865-6rafp3x3 324 53 . . . cord-023865-6rafp3x3 325 1 This this DT cord-023865-6rafp3x3 325 2 may may MD cord-023865-6rafp3x3 325 3 be be VB cord-023865-6rafp3x3 325 4 attributed attribute VBN cord-023865-6rafp3x3 325 5 to to IN cord-023865-6rafp3x3 325 6 the the DT cord-023865-6rafp3x3 325 7 localization localization NN cord-023865-6rafp3x3 325 8 of of IN cord-023865-6rafp3x3 325 9 N n NN cord-023865-6rafp3x3 325 10 - - HYPH cord-023865-6rafp3x3 325 11 protein protein NN cord-023865-6rafp3x3 325 12 inside inside IN cord-023865-6rafp3x3 325 13 the the DT cord-023865-6rafp3x3 325 14 viral viral JJ cord-023865-6rafp3x3 325 15 envelope envelope NN cord-023865-6rafp3x3 325 16 , , , cord-023865-6rafp3x3 325 17 which which WDT cord-023865-6rafp3x3 325 18 will will MD cord-023865-6rafp3x3 325 19 not not RB cord-023865-6rafp3x3 325 20 be be VB cord-023865-6rafp3x3 325 21 accessible accessible JJ cord-023865-6rafp3x3 325 22 to to IN cord-023865-6rafp3x3 325 23 the the DT cord-023865-6rafp3x3 325 24 antibody antibody NN cord-023865-6rafp3x3 325 25 during during IN cord-023865-6rafp3x3 325 26 infection infection NN cord-023865-6rafp3x3 325 27 . . . cord-023865-6rafp3x3 326 1 It -PRON- PRP cord-023865-6rafp3x3 326 2 is be VBZ cord-023865-6rafp3x3 326 3 noteworthy noteworthy JJ cord-023865-6rafp3x3 326 4 that that IN cord-023865-6rafp3x3 326 5 the the DT cord-023865-6rafp3x3 326 6 most most RBS cord-023865-6rafp3x3 326 7 effective effective JJ cord-023865-6rafp3x3 326 8 SARS SARS NNP cord-023865-6rafp3x3 326 9 - - HYPH cord-023865-6rafp3x3 326 10 CoV CoV NNP cord-023865-6rafp3x3 326 11 structural structural JJ cord-023865-6rafp3x3 326 12 protein protein NN cord-023865-6rafp3x3 326 13 that that WDT cord-023865-6rafp3x3 326 14 can can MD cord-023865-6rafp3x3 326 15 induce induce VB cord-023865-6rafp3x3 326 16 neutralizing neutralize VBG cord-023865-6rafp3x3 326 17 antibody antibody NN cord-023865-6rafp3x3 326 18 production production NN cord-023865-6rafp3x3 326 19 is be VBZ cord-023865-6rafp3x3 326 20 the the DT cord-023865-6rafp3x3 326 21 S S NNP cord-023865-6rafp3x3 326 22 - - HYPH cord-023865-6rafp3x3 326 23 protein protein NN cord-023865-6rafp3x3 326 24 ( ( -LRB- cord-023865-6rafp3x3 326 25 Buchholz Buchholz NNP cord-023865-6rafp3x3 326 26 et et NNP cord-023865-6rafp3x3 326 27 al al NNP cord-023865-6rafp3x3 326 28 . . . cord-023865-6rafp3x3 326 29 2004 2004 CD cord-023865-6rafp3x3 326 30 ) ) -RRB- cord-023865-6rafp3x3 326 31 . . . cord-023865-6rafp3x3 327 1 The the DT cord-023865-6rafp3x3 327 2 S S NNP cord-023865-6rafp3x3 327 3 - - HYPH cord-023865-6rafp3x3 327 4 protein protein NN cord-023865-6rafp3x3 327 5 antibody antibody NN cord-023865-6rafp3x3 327 6 could could MD cord-023865-6rafp3x3 327 7 block block VB cord-023865-6rafp3x3 327 8 viral viral JJ cord-023865-6rafp3x3 327 9 infection infection NN cord-023865-6rafp3x3 327 10 with with IN cord-023865-6rafp3x3 327 11 100 100 CD cord-023865-6rafp3x3 327 12 % % NN cord-023865-6rafp3x3 327 13 efficiency efficiency NN cord-023865-6rafp3x3 327 14 . . . cord-023865-6rafp3x3 328 1 On on IN cord-023865-6rafp3x3 328 2 the the DT cord-023865-6rafp3x3 328 3 other other JJ cord-023865-6rafp3x3 328 4 hand hand NN cord-023865-6rafp3x3 328 5 , , , cord-023865-6rafp3x3 328 6 although although IN cord-023865-6rafp3x3 328 7 unable unable JJ cord-023865-6rafp3x3 328 8 to to TO cord-023865-6rafp3x3 328 9 induce induce VB cord-023865-6rafp3x3 328 10 humoral humoral JJ cord-023865-6rafp3x3 328 11 immunity immunity NN cord-023865-6rafp3x3 328 12 , , , cord-023865-6rafp3x3 328 13 expression expression NN cord-023865-6rafp3x3 328 14 of of IN cord-023865-6rafp3x3 328 15 N n CD cord-023865-6rafp3x3 328 16 - - HYPH cord-023865-6rafp3x3 328 17 protein protein NN cord-023865-6rafp3x3 328 18 induced induce VBD cord-023865-6rafp3x3 328 19 significant significant JJ cord-023865-6rafp3x3 328 20 cytotoxic cytotoxic JJ cord-023865-6rafp3x3 328 21 T t NN cord-023865-6rafp3x3 328 22 - - HYPH cord-023865-6rafp3x3 328 23 lymphocyte lymphocyte NN cord-023865-6rafp3x3 328 24 ( ( -LRB- cord-023865-6rafp3x3 328 25 CTL CTL NNP cord-023865-6rafp3x3 328 26 ) ) -RRB- cord-023865-6rafp3x3 328 27 response response NN cord-023865-6rafp3x3 328 28 ( ( -LRB- cord-023865-6rafp3x3 328 29 Buchholz Buchholz NNP cord-023865-6rafp3x3 328 30 et et NNP cord-023865-6rafp3x3 328 31 al al NNP cord-023865-6rafp3x3 328 32 . . . cord-023865-6rafp3x3 328 33 2004 2004 CD cord-023865-6rafp3x3 328 34 ; ; : cord-023865-6rafp3x3 328 35 Gao Gao NNP cord-023865-6rafp3x3 328 36 et et NNP cord-023865-6rafp3x3 328 37 al al NNP cord-023865-6rafp3x3 328 38 . . . cord-023865-6rafp3x3 329 1 2003 2003 CD cord-023865-6rafp3x3 329 2 ; ; : cord-023865-6rafp3x3 329 3 Zhu Zhu NNP cord-023865-6rafp3x3 329 4 et et FW cord-023865-6rafp3x3 329 5 al al NNP cord-023865-6rafp3x3 329 6 . . . cord-023865-6rafp3x3 329 7 2004 2004 CD cord-023865-6rafp3x3 329 8 ) ) -RRB- cord-023865-6rafp3x3 329 9 . . . cord-023865-6rafp3x3 330 1 Induction Induction NNP cord-023865-6rafp3x3 330 2 of of IN cord-023865-6rafp3x3 330 3 N N NNP cord-023865-6rafp3x3 330 4 - - HYPH cord-023865-6rafp3x3 330 5 protein protein NN cord-023865-6rafp3x3 330 6 - - HYPH cord-023865-6rafp3x3 330 7 specific specific JJ cord-023865-6rafp3x3 330 8 CTLs ctl NNS cord-023865-6rafp3x3 330 9 will will MD cord-023865-6rafp3x3 330 10 help help VB cord-023865-6rafp3x3 330 11 limit limit VB cord-023865-6rafp3x3 330 12 the the DT cord-023865-6rafp3x3 330 13 infection infection NN cord-023865-6rafp3x3 330 14 by by IN cord-023865-6rafp3x3 330 15 lysing lyse VBG cord-023865-6rafp3x3 330 16 virus virus NN cord-023865-6rafp3x3 330 17 infected infect VBN cord-023865-6rafp3x3 330 18 cells cell NNS cord-023865-6rafp3x3 330 19 . . . cord-023865-6rafp3x3 331 1 This this DT cord-023865-6rafp3x3 331 2 will will MD cord-023865-6rafp3x3 331 3 also also RB cord-023865-6rafp3x3 331 4 limit limit VB cord-023865-6rafp3x3 331 5 the the DT cord-023865-6rafp3x3 331 6 spread spread NN cord-023865-6rafp3x3 331 7 of of IN cord-023865-6rafp3x3 331 8 virus virus NN cord-023865-6rafp3x3 331 9 . . . cord-023865-6rafp3x3 332 1 Thus thus RB cord-023865-6rafp3x3 332 2 , , , cord-023865-6rafp3x3 332 3 N n CD cord-023865-6rafp3x3 332 4 - - HYPH cord-023865-6rafp3x3 332 5 protein protein NN cord-023865-6rafp3x3 332 6 - - HYPH cord-023865-6rafp3x3 332 7 based base VBN cord-023865-6rafp3x3 332 8 vaccines vaccine NNS cord-023865-6rafp3x3 332 9 may may MD cord-023865-6rafp3x3 332 10 further further RB cord-023865-6rafp3x3 332 11 augment augment VB cord-023865-6rafp3x3 332 12 the the DT cord-023865-6rafp3x3 332 13 protection protection NN cord-023865-6rafp3x3 332 14 efficiency efficiency NN cord-023865-6rafp3x3 332 15 when when WRB cord-023865-6rafp3x3 332 16 coadministered coadministere VBN cord-023865-6rafp3x3 332 17 with with IN cord-023865-6rafp3x3 332 18 S s NN cord-023865-6rafp3x3 332 19 - - HYPH cord-023865-6rafp3x3 332 20 protein protein NN cord-023865-6rafp3x3 332 21 - - HYPH cord-023865-6rafp3x3 332 22 based base VBN cord-023865-6rafp3x3 332 23 vaccine vaccine NN cord-023865-6rafp3x3 332 24 . . . cord-023865-6rafp3x3 333 1 Several several JJ cord-023865-6rafp3x3 333 2 laboratories laboratory NNS cord-023865-6rafp3x3 333 3 have have VBP cord-023865-6rafp3x3 333 4 been be VBN cord-023865-6rafp3x3 333 5 exploring explore VBG cord-023865-6rafp3x3 333 6 various various JJ cord-023865-6rafp3x3 333 7 strategies strategy NNS cord-023865-6rafp3x3 333 8 to to TO cord-023865-6rafp3x3 333 9 evaluate evaluate VB cord-023865-6rafp3x3 333 10 the the DT cord-023865-6rafp3x3 333 11 potential potential NN cord-023865-6rafp3x3 333 12 of of IN cord-023865-6rafp3x3 333 13 N n NN cord-023865-6rafp3x3 333 14 - - HYPH cord-023865-6rafp3x3 333 15 protein protein NN cord-023865-6rafp3x3 333 16 as as IN cord-023865-6rafp3x3 333 17 a a DT cord-023865-6rafp3x3 333 18 vaccine vaccine NN cord-023865-6rafp3x3 333 19 candidate candidate NN cord-023865-6rafp3x3 333 20 . . . cord-023865-6rafp3x3 334 1 In in IN cord-023865-6rafp3x3 334 2 an an DT cord-023865-6rafp3x3 334 3 elegant elegant JJ cord-023865-6rafp3x3 334 4 work work NN cord-023865-6rafp3x3 334 5 done do VBN cord-023865-6rafp3x3 334 6 by by IN cord-023865-6rafp3x3 334 7 Kim Kim NNP cord-023865-6rafp3x3 334 8 et et NNP cord-023865-6rafp3x3 334 9 al al NNP cord-023865-6rafp3x3 334 10 . . . cord-023865-6rafp3x3 335 1 ( ( -LRB- cord-023865-6rafp3x3 335 2 2004 2004 CD cord-023865-6rafp3x3 335 3 ) ) -RRB- cord-023865-6rafp3x3 335 4 , , , cord-023865-6rafp3x3 335 5 calreticulin calreticulin NNP cord-023865-6rafp3x3 335 6 - - HYPH cord-023865-6rafp3x3 335 7 fused fuse VBN cord-023865-6rafp3x3 335 8 N N NNP cord-023865-6rafp3x3 335 9 - - HYPH cord-023865-6rafp3x3 335 10 protein protein NN cord-023865-6rafp3x3 335 11 expressing express VBG cord-023865-6rafp3x3 335 12 vaccinia vaccinia NN cord-023865-6rafp3x3 335 13 virus virus NN cord-023865-6rafp3x3 335 14 has have VBZ cord-023865-6rafp3x3 335 15 been be VBN cord-023865-6rafp3x3 335 16 shown show VBN cord-023865-6rafp3x3 335 17 to to TO cord-023865-6rafp3x3 335 18 generate generate VB cord-023865-6rafp3x3 335 19 potent potent JJ cord-023865-6rafp3x3 335 20 N n CD cord-023865-6rafp3x3 335 21 - - HYPH cord-023865-6rafp3x3 335 22 protein protein NN cord-023865-6rafp3x3 335 23 - - HYPH cord-023865-6rafp3x3 335 24 specific specific JJ cord-023865-6rafp3x3 335 25 humoral humoral JJ cord-023865-6rafp3x3 335 26 and and CC cord-023865-6rafp3x3 335 27 T t NN cord-023865-6rafp3x3 335 28 - - HYPH cord-023865-6rafp3x3 335 29 cell cell NN cord-023865-6rafp3x3 335 30 immune immune JJ cord-023865-6rafp3x3 335 31 responses response NNS cord-023865-6rafp3x3 335 32 in in IN cord-023865-6rafp3x3 335 33 mice mouse NNS cord-023865-6rafp3x3 335 34 . . . cord-023865-6rafp3x3 336 1 As as IN cord-023865-6rafp3x3 336 2 reported report VBN cord-023865-6rafp3x3 336 3 by by IN cord-023865-6rafp3x3 336 4 the the DT cord-023865-6rafp3x3 336 5 authors author NNS cord-023865-6rafp3x3 336 6 , , , cord-023865-6rafp3x3 336 7 fusion fusion NN cord-023865-6rafp3x3 336 8 with with IN cord-023865-6rafp3x3 336 9 calreticulin calreticulin NNP cord-023865-6rafp3x3 336 10 specifically specifically RB cord-023865-6rafp3x3 336 11 enhanced enhance VBD cord-023865-6rafp3x3 336 12 the the DT cord-023865-6rafp3x3 336 13 efficiency efficiency NN cord-023865-6rafp3x3 336 14 and and CC cord-023865-6rafp3x3 336 15 significantly significantly RB cord-023865-6rafp3x3 336 16 reduced reduce VBD cord-023865-6rafp3x3 336 17 the the DT cord-023865-6rafp3x3 336 18 titer titer NN cord-023865-6rafp3x3 336 19 of of IN cord-023865-6rafp3x3 336 20 the the DT cord-023865-6rafp3x3 336 21 challenging challenging JJ cord-023865-6rafp3x3 336 22 vector vector NN cord-023865-6rafp3x3 336 23 ( ( -LRB- cord-023865-6rafp3x3 336 24 vaccinia vaccinia NN cord-023865-6rafp3x3 336 25 virus virus NN cord-023865-6rafp3x3 336 26 ) ) -RRB- cord-023865-6rafp3x3 336 27 . . . cord-023865-6rafp3x3 337 1 The the DT cord-023865-6rafp3x3 337 2 authors author NNS cord-023865-6rafp3x3 337 3 have have VBP cord-023865-6rafp3x3 337 4 proposed propose VBN cord-023865-6rafp3x3 337 5 that that IN cord-023865-6rafp3x3 337 6 N n NN cord-023865-6rafp3x3 337 7 - - HYPH cord-023865-6rafp3x3 337 8 protein protein NN cord-023865-6rafp3x3 337 9 may may MD cord-023865-6rafp3x3 337 10 be be VB cord-023865-6rafp3x3 337 11 the the DT cord-023865-6rafp3x3 337 12 logical logical JJ cord-023865-6rafp3x3 337 13 choice choice NN cord-023865-6rafp3x3 337 14 as as IN cord-023865-6rafp3x3 337 15 a a DT cord-023865-6rafp3x3 337 16 target target NN cord-023865-6rafp3x3 337 17 antigen antigen NN cord-023865-6rafp3x3 337 18 in in IN cord-023865-6rafp3x3 337 19 the the DT cord-023865-6rafp3x3 337 20 event event NN cord-023865-6rafp3x3 337 21 of of IN cord-023865-6rafp3x3 337 22 S S NNP cord-023865-6rafp3x3 337 23 - - HYPH cord-023865-6rafp3x3 337 24 protein protein NN cord-023865-6rafp3x3 337 25 antibody antibody NN cord-023865-6rafp3x3 337 26 - - HYPH cord-023865-6rafp3x3 337 27 dependent dependent JJ cord-023865-6rafp3x3 337 28 enhancement enhancement NN cord-023865-6rafp3x3 337 29 ( ( -LRB- cord-023865-6rafp3x3 337 30 ADE ADE NNP cord-023865-6rafp3x3 337 31 ) ) -RRB- cord-023865-6rafp3x3 337 32 of of IN cord-023865-6rafp3x3 337 33 infection infection NN cord-023865-6rafp3x3 337 34 . . . cord-023865-6rafp3x3 338 1 However however RB cord-023865-6rafp3x3 338 2 , , , cord-023865-6rafp3x3 338 3 the the DT cord-023865-6rafp3x3 338 4 ADE ADE NNP cord-023865-6rafp3x3 338 5 phenomenon phenomenon NN cord-023865-6rafp3x3 338 6 has have VBZ cord-023865-6rafp3x3 338 7 not not RB cord-023865-6rafp3x3 338 8 been be VBN cord-023865-6rafp3x3 338 9 observed observe VBN cord-023865-6rafp3x3 338 10 during during IN cord-023865-6rafp3x3 338 11 spike spike NN cord-023865-6rafp3x3 338 12 - - HYPH cord-023865-6rafp3x3 338 13 mediated mediate VBN cord-023865-6rafp3x3 338 14 vaccination vaccination NN cord-023865-6rafp3x3 338 15 ( ( -LRB- cord-023865-6rafp3x3 338 16 Buchholz Buchholz NNP cord-023865-6rafp3x3 338 17 et et NNP cord-023865-6rafp3x3 338 18 al al NNP cord-023865-6rafp3x3 338 19 . . . cord-023865-6rafp3x3 338 20 2004 2004 CD cord-023865-6rafp3x3 338 21 ) ) -RRB- cord-023865-6rafp3x3 338 22 . . . cord-023865-6rafp3x3 339 1 Another another DT cord-023865-6rafp3x3 339 2 study study NN cord-023865-6rafp3x3 339 3 done do VBN cord-023865-6rafp3x3 339 4 by by IN cord-023865-6rafp3x3 339 5 Wang Wang NNP cord-023865-6rafp3x3 339 6 et et NNP cord-023865-6rafp3x3 339 7 al al NNP cord-023865-6rafp3x3 339 8 . . . cord-023865-6rafp3x3 340 1 ( ( -LRB- cord-023865-6rafp3x3 340 2 2005 2005 CD cord-023865-6rafp3x3 340 3 ) ) -RRB- cord-023865-6rafp3x3 340 4 has have VBZ cord-023865-6rafp3x3 340 5 attempted attempt VBN cord-023865-6rafp3x3 340 6 to to TO cord-023865-6rafp3x3 340 7 use use VB cord-023865-6rafp3x3 340 8 plasmid plasmid NN cord-023865-6rafp3x3 340 9 DNA dna NN cord-023865-6rafp3x3 340 10 expressing express VBG cord-023865-6rafp3x3 340 11 S S NNP cord-023865-6rafp3x3 340 12 , , , cord-023865-6rafp3x3 340 13 M M NNP cord-023865-6rafp3x3 340 14 , , , cord-023865-6rafp3x3 340 15 and and CC cord-023865-6rafp3x3 340 16 N n CD cord-023865-6rafp3x3 340 17 proteins protein NNS cord-023865-6rafp3x3 340 18 as as IN cord-023865-6rafp3x3 340 19 an an DT cord-023865-6rafp3x3 340 20 efficient efficient JJ cord-023865-6rafp3x3 340 21 vaccine vaccine NN cord-023865-6rafp3x3 340 22 candidate candidate NN cord-023865-6rafp3x3 340 23 . . . cord-023865-6rafp3x3 341 1 Although although IN cord-023865-6rafp3x3 341 2 they -PRON- PRP cord-023865-6rafp3x3 341 3 report report VBP cord-023865-6rafp3x3 341 4 the the DT cord-023865-6rafp3x3 341 5 production production NN cord-023865-6rafp3x3 341 6 of of IN cord-023865-6rafp3x3 341 7 some some DT cord-023865-6rafp3x3 341 8 B b NN cord-023865-6rafp3x3 341 9 - - HYPH cord-023865-6rafp3x3 341 10 cell cell NN cord-023865-6rafp3x3 341 11 and and CC cord-023865-6rafp3x3 341 12 T t NN cord-023865-6rafp3x3 341 13 - - HYPH cord-023865-6rafp3x3 341 14 cell cell NN cord-023865-6rafp3x3 341 15 responses response NNS cord-023865-6rafp3x3 341 16 against against IN cord-023865-6rafp3x3 341 17 N n CD cord-023865-6rafp3x3 341 18 - - HYPH cord-023865-6rafp3x3 341 19 protein protein NN cord-023865-6rafp3x3 341 20 , , , cord-023865-6rafp3x3 341 21 strong strong JJ cord-023865-6rafp3x3 341 22 immune immune JJ cord-023865-6rafp3x3 341 23 response response NN cord-023865-6rafp3x3 341 24 was be VBD cord-023865-6rafp3x3 341 25 obtained obtain VBN cord-023865-6rafp3x3 341 26 for for IN cord-023865-6rafp3x3 341 27 the the DT cord-023865-6rafp3x3 341 28 S S NNP cord-023865-6rafp3x3 341 29 and and CC cord-023865-6rafp3x3 341 30 M M NNP cord-023865-6rafp3x3 341 31 proteins protein NNS cord-023865-6rafp3x3 341 32 , , , cord-023865-6rafp3x3 341 33 thus thus RB cord-023865-6rafp3x3 341 34 scaling scale VBG cord-023865-6rafp3x3 341 35 down down RP cord-023865-6rafp3x3 341 36 the the DT cord-023865-6rafp3x3 341 37 choice choice NN cord-023865-6rafp3x3 341 38 of of IN cord-023865-6rafp3x3 341 39 N n NN cord-023865-6rafp3x3 341 40 - - HYPH cord-023865-6rafp3x3 341 41 protein protein NN cord-023865-6rafp3x3 341 42 as as IN cord-023865-6rafp3x3 341 43 a a DT cord-023865-6rafp3x3 341 44 suitable suitable JJ cord-023865-6rafp3x3 341 45 candidate candidate NN cord-023865-6rafp3x3 341 46 vaccine vaccine NN cord-023865-6rafp3x3 341 47 . . . cord-023865-6rafp3x3 342 1 A a DT cord-023865-6rafp3x3 342 2 similar similar JJ cord-023865-6rafp3x3 342 3 plasmid plasmid NN cord-023865-6rafp3x3 342 4 - - HYPH cord-023865-6rafp3x3 342 5 mediated mediate VBN cord-023865-6rafp3x3 342 6 vaccination vaccination NN cord-023865-6rafp3x3 342 7 approach approach NN cord-023865-6rafp3x3 342 8 has have VBZ cord-023865-6rafp3x3 342 9 also also RB cord-023865-6rafp3x3 342 10 been be VBN cord-023865-6rafp3x3 342 11 reported report VBN cord-023865-6rafp3x3 342 12 by by IN cord-023865-6rafp3x3 342 13 Zhao Zhao NNP cord-023865-6rafp3x3 342 14 et et NNP cord-023865-6rafp3x3 342 15 al al NNP cord-023865-6rafp3x3 342 16 . . . cord-023865-6rafp3x3 343 1 ( ( -LRB- cord-023865-6rafp3x3 343 2 2004 2004 CD cord-023865-6rafp3x3 343 3 ) ) -RRB- cord-023865-6rafp3x3 343 4 , , , cord-023865-6rafp3x3 343 5 in in IN cord-023865-6rafp3x3 343 6 which which WDT cord-023865-6rafp3x3 343 7 they -PRON- PRP cord-023865-6rafp3x3 343 8 immunized immunize VBD cord-023865-6rafp3x3 343 9 mice mouse NNS cord-023865-6rafp3x3 343 10 with with IN cord-023865-6rafp3x3 343 11 the the DT cord-023865-6rafp3x3 343 12 DNA dna NN cord-023865-6rafp3x3 343 13 construct construct NN cord-023865-6rafp3x3 343 14 ( ( -LRB- cord-023865-6rafp3x3 343 15 pCI pCI NNP cord-023865-6rafp3x3 343 16 vector vector NN cord-023865-6rafp3x3 343 17 ) ) -RRB- cord-023865-6rafp3x3 343 18 expressing express VBG cord-023865-6rafp3x3 343 19 the the DT cord-023865-6rafp3x3 343 20 N n NN cord-023865-6rafp3x3 343 21 - - HYPH cord-023865-6rafp3x3 343 22 protein protein NN cord-023865-6rafp3x3 343 23 . . . cord-023865-6rafp3x3 344 1 They -PRON- PRP cord-023865-6rafp3x3 344 2 too too RB cord-023865-6rafp3x3 344 3 reported report VBD cord-023865-6rafp3x3 344 4 the the DT cord-023865-6rafp3x3 344 5 generation generation NN cord-023865-6rafp3x3 344 6 of of IN cord-023865-6rafp3x3 344 7 a a DT cord-023865-6rafp3x3 344 8 robust robust JJ cord-023865-6rafp3x3 344 9 B b NN cord-023865-6rafp3x3 344 10 - - HYPH cord-023865-6rafp3x3 344 11 cell cell NN cord-023865-6rafp3x3 344 12 and and CC cord-023865-6rafp3x3 344 13 T t NN cord-023865-6rafp3x3 344 14 - - HYPH cord-023865-6rafp3x3 344 15 cell cell NN cord-023865-6rafp3x3 344 16 immune immune JJ cord-023865-6rafp3x3 344 17 response response NN cord-023865-6rafp3x3 344 18 in in IN cord-023865-6rafp3x3 344 19 animals animal NNS cord-023865-6rafp3x3 344 20 . . . cord-023865-6rafp3x3 345 1 Another another DT cord-023865-6rafp3x3 345 2 group group NN cord-023865-6rafp3x3 345 3 of of IN cord-023865-6rafp3x3 345 4 workers worker NNS cord-023865-6rafp3x3 345 5 has have VBZ cord-023865-6rafp3x3 345 6 also also RB cord-023865-6rafp3x3 345 7 reported report VBN cord-023865-6rafp3x3 345 8 successful successful JJ cord-023865-6rafp3x3 345 9 use use NN cord-023865-6rafp3x3 345 10 of of IN cord-023865-6rafp3x3 345 11 the the DT cord-023865-6rafp3x3 345 12 N n NN cord-023865-6rafp3x3 345 13 - - HYPH cord-023865-6rafp3x3 345 14 protein protein NN cord-023865-6rafp3x3 345 15 as as IN cord-023865-6rafp3x3 345 16 a a DT cord-023865-6rafp3x3 345 17 DNA dna NN cord-023865-6rafp3x3 345 18 vaccine vaccine NN cord-023865-6rafp3x3 345 19 . . . cord-023865-6rafp3x3 346 1 They -PRON- PRP cord-023865-6rafp3x3 346 2 immunized immunize VBD cord-023865-6rafp3x3 346 3 mice mouse NNS cord-023865-6rafp3x3 346 4 by by IN cord-023865-6rafp3x3 346 5 intramucosal intramucosal NNP cord-023865-6rafp3x3 346 6 injection injection NN cord-023865-6rafp3x3 346 7 of of IN cord-023865-6rafp3x3 346 8 the the DT cord-023865-6rafp3x3 346 9 N n CD cord-023865-6rafp3x3 346 10 - - HYPH cord-023865-6rafp3x3 346 11 protein protein NN cord-023865-6rafp3x3 346 12 - - HYPH cord-023865-6rafp3x3 346 13 expressing express VBG cord-023865-6rafp3x3 346 14 plasmid plasmid NN cord-023865-6rafp3x3 346 15 vector vector NN cord-023865-6rafp3x3 346 16 and and CC cord-023865-6rafp3x3 346 17 were be VBD cord-023865-6rafp3x3 346 18 able able JJ cord-023865-6rafp3x3 346 19 to to TO cord-023865-6rafp3x3 346 20 obtain obtain VB cord-023865-6rafp3x3 346 21 specific specific JJ cord-023865-6rafp3x3 346 22 humoral humoral JJ cord-023865-6rafp3x3 346 23 and and CC cord-023865-6rafp3x3 346 24 T t NN cord-023865-6rafp3x3 346 25 - - HYPH cord-023865-6rafp3x3 346 26 cell cell NN cord-023865-6rafp3x3 346 27 responses response NNS cord-023865-6rafp3x3 346 28 ( ( -LRB- cord-023865-6rafp3x3 346 29 Zhu zhu FW cord-023865-6rafp3x3 346 30 et et FW cord-023865-6rafp3x3 346 31 al al NNP cord-023865-6rafp3x3 346 32 . . . cord-023865-6rafp3x3 346 33 2004 2004 CD cord-023865-6rafp3x3 346 34 ) ) -RRB- cord-023865-6rafp3x3 346 35 . . . cord-023865-6rafp3x3 347 1 The the DT cord-023865-6rafp3x3 347 2 N N NNP cord-023865-6rafp3x3 347 3 - - HYPH cord-023865-6rafp3x3 347 4 protein protein NN cord-023865-6rafp3x3 347 5 has have VBZ cord-023865-6rafp3x3 347 6 also also RB cord-023865-6rafp3x3 347 7 been be VBN cord-023865-6rafp3x3 347 8 reported report VBN cord-023865-6rafp3x3 347 9 to to TO cord-023865-6rafp3x3 347 10 be be VB cord-023865-6rafp3x3 347 11 of of IN cord-023865-6rafp3x3 347 12 potential potential JJ cord-023865-6rafp3x3 347 13 interest interest NN cord-023865-6rafp3x3 347 14 as as IN cord-023865-6rafp3x3 347 15 a a DT cord-023865-6rafp3x3 347 16 peptidebased peptidebased JJ cord-023865-6rafp3x3 347 17 vaccine vaccine NN cord-023865-6rafp3x3 347 18 . . . cord-023865-6rafp3x3 348 1 A a DT cord-023865-6rafp3x3 348 2 systematic systematic JJ cord-023865-6rafp3x3 348 3 study study NN cord-023865-6rafp3x3 348 4 done do VBN cord-023865-6rafp3x3 348 5 by by IN cord-023865-6rafp3x3 348 6 Liu Liu NNP cord-023865-6rafp3x3 348 7 et et NNP cord-023865-6rafp3x3 348 8 al al NNP cord-023865-6rafp3x3 348 9 . . . cord-023865-6rafp3x3 349 1 ( ( -LRB- cord-023865-6rafp3x3 349 2 2006 2006 CD cord-023865-6rafp3x3 349 3 ) ) -RRB- cord-023865-6rafp3x3 349 4 has have VBZ cord-023865-6rafp3x3 349 5 revealed reveal VBN cord-023865-6rafp3x3 349 6 the the DT cord-023865-6rafp3x3 349 7 immunodominant immunodominant JJ cord-023865-6rafp3x3 349 8 epitopes epitope NNS cord-023865-6rafp3x3 349 9 of of IN cord-023865-6rafp3x3 349 10 the the DT cord-023865-6rafp3x3 349 11 N N NNP cord-023865-6rafp3x3 349 12 - - HYPH cord-023865-6rafp3x3 349 13 protein protein NN cord-023865-6rafp3x3 349 14 which which WDT cord-023865-6rafp3x3 349 15 could could MD cord-023865-6rafp3x3 349 16 efficiently efficiently RB cord-023865-6rafp3x3 349 17 stimulate stimulate VB cord-023865-6rafp3x3 349 18 immune immune JJ cord-023865-6rafp3x3 349 19 response response NN cord-023865-6rafp3x3 349 20 . . . cord-023865-6rafp3x3 350 1 They -PRON- PRP cord-023865-6rafp3x3 350 2 have have VBP cord-023865-6rafp3x3 350 3 also also RB cord-023865-6rafp3x3 350 4 deduced deduce VBN cord-023865-6rafp3x3 350 5 some some DT cord-023865-6rafp3x3 350 6 conserved conserve VBN cord-023865-6rafp3x3 350 7 immunodominant immunodominant JJ cord-023865-6rafp3x3 350 8 epitopes epitope NNS cord-023865-6rafp3x3 350 9 in in IN cord-023865-6rafp3x3 350 10 mouse mouse NN cord-023865-6rafp3x3 350 11 , , , cord-023865-6rafp3x3 350 12 monkey monkey NN cord-023865-6rafp3x3 350 13 , , , cord-023865-6rafp3x3 350 14 and and CC cord-023865-6rafp3x3 350 15 humans human NNS cord-023865-6rafp3x3 350 16 , , , cord-023865-6rafp3x3 350 17 which which WDT cord-023865-6rafp3x3 350 18 may may MD cord-023865-6rafp3x3 350 19 help help VB cord-023865-6rafp3x3 350 20 in in IN cord-023865-6rafp3x3 350 21 design design NN cord-023865-6rafp3x3 350 22 of of IN cord-023865-6rafp3x3 350 23 the the DT cord-023865-6rafp3x3 350 24 vaccine vaccine NN cord-023865-6rafp3x3 350 25 . . . cord-023865-6rafp3x3 351 1 A a DT cord-023865-6rafp3x3 351 2 recent recent JJ cord-023865-6rafp3x3 351 3 report report NN cord-023865-6rafp3x3 351 4 published publish VBN cord-023865-6rafp3x3 351 5 by by IN cord-023865-6rafp3x3 351 6 Gao Gao NNP cord-023865-6rafp3x3 351 7 's 's POS cord-023865-6rafp3x3 351 8 laboratory laboratory NN cord-023865-6rafp3x3 351 9 provides provide VBZ cord-023865-6rafp3x3 351 10 further further JJ cord-023865-6rafp3x3 351 11 evidence evidence NN cord-023865-6rafp3x3 351 12 regarding regard VBG cord-023865-6rafp3x3 351 13 the the DT cord-023865-6rafp3x3 351 14 efficiency efficiency NN cord-023865-6rafp3x3 351 15 of of IN cord-023865-6rafp3x3 351 16 an an DT cord-023865-6rafp3x3 351 17 N n CD cord-023865-6rafp3x3 351 18 - - HYPH cord-023865-6rafp3x3 351 19 protein protein NN cord-023865-6rafp3x3 351 20 - - HYPH cord-023865-6rafp3x3 351 21 based base VBN cord-023865-6rafp3x3 351 22 vaccine vaccine NN cord-023865-6rafp3x3 351 23 ( ( -LRB- cord-023865-6rafp3x3 351 24 Zhao Zhao NNP cord-023865-6rafp3x3 351 25 et et NNP cord-023865-6rafp3x3 351 26 al al NNP cord-023865-6rafp3x3 351 27 . . NNP cord-023865-6rafp3x3 351 28 2007 2007 CD cord-023865-6rafp3x3 351 29 ) ) -RRB- cord-023865-6rafp3x3 351 30 . . . cord-023865-6rafp3x3 352 1 By by IN cord-023865-6rafp3x3 352 2 using use VBG cord-023865-6rafp3x3 352 3 overlapping overlap VBG cord-023865-6rafp3x3 352 4 synthetic synthetic JJ cord-023865-6rafp3x3 352 5 peptides peptide NNS cord-023865-6rafp3x3 352 6 spanning span VBG cord-023865-6rafp3x3 352 7 the the DT cord-023865-6rafp3x3 352 8 N n CD cord-023865-6rafp3x3 352 9 - - HYPH cord-023865-6rafp3x3 352 10 protein protein NN cord-023865-6rafp3x3 352 11 , , , cord-023865-6rafp3x3 352 12 they -PRON- PRP cord-023865-6rafp3x3 352 13 have have VBP cord-023865-6rafp3x3 352 14 identified identify VBN cord-023865-6rafp3x3 352 15 dominant dominant JJ cord-023865-6rafp3x3 352 16 helper helper NN cord-023865-6rafp3x3 352 17 T t NN cord-023865-6rafp3x3 352 18 - - HYPH cord-023865-6rafp3x3 352 19 cell cell NN cord-023865-6rafp3x3 352 20 epitopes epitope NNS cord-023865-6rafp3x3 352 21 in in IN cord-023865-6rafp3x3 352 22 the the DT cord-023865-6rafp3x3 352 23 N n NN cord-023865-6rafp3x3 352 24 - - HYPH cord-023865-6rafp3x3 352 25 protein protein NN cord-023865-6rafp3x3 352 26 of of IN cord-023865-6rafp3x3 352 27 SARS SARS NNP cord-023865-6rafp3x3 352 28 - - HYPH cord-023865-6rafp3x3 352 29 CoV. CoV. NNP cord-023865-6rafp3x3 352 30 Immunization Immunization NNP cord-023865-6rafp3x3 352 31 of of IN cord-023865-6rafp3x3 352 32 mice mouse NNS cord-023865-6rafp3x3 352 33 with with IN cord-023865-6rafp3x3 352 34 peptides peptide NNS cord-023865-6rafp3x3 352 35 emcompassing emcompasse VBG cord-023865-6rafp3x3 352 36 these these DT cord-023865-6rafp3x3 352 37 dominant dominant JJ cord-023865-6rafp3x3 352 38 TH TH NNP cord-023865-6rafp3x3 352 39 cell cell NN cord-023865-6rafp3x3 352 40 epitopes epitope NNS cord-023865-6rafp3x3 352 41 resulted result VBN cord-023865-6rafp3x3 352 42 in in IN cord-023865-6rafp3x3 352 43 strong strong JJ cord-023865-6rafp3x3 352 44 cellular cellular JJ cord-023865-6rafp3x3 352 45 immunity immunity NN cord-023865-6rafp3x3 352 46 in in IN cord-023865-6rafp3x3 352 47 vivo vivo NN cord-023865-6rafp3x3 352 48 . . . cord-023865-6rafp3x3 353 1 Priming prime VBG cord-023865-6rafp3x3 353 2 with with IN cord-023865-6rafp3x3 353 3 the the DT cord-023865-6rafp3x3 353 4 helper helper NN cord-023865-6rafp3x3 353 5 peptides peptide NNS cord-023865-6rafp3x3 353 6 significantly significantly RB cord-023865-6rafp3x3 353 7 accelerated accelerate VBD cord-023865-6rafp3x3 353 8 the the DT cord-023865-6rafp3x3 353 9 immune immune JJ cord-023865-6rafp3x3 353 10 response response NN cord-023865-6rafp3x3 353 11 induced induce VBN cord-023865-6rafp3x3 353 12 by by IN cord-023865-6rafp3x3 353 13 the the DT cord-023865-6rafp3x3 353 14 N N NNP cord-023865-6rafp3x3 353 15 - - HYPH cord-023865-6rafp3x3 353 16 protein protein NN cord-023865-6rafp3x3 353 17 . . . cord-023865-6rafp3x3 354 1 Further further RB cord-023865-6rafp3x3 354 2 , , , cord-023865-6rafp3x3 354 3 by by IN cord-023865-6rafp3x3 354 4 fusing fuse VBG cord-023865-6rafp3x3 354 5 with with IN cord-023865-6rafp3x3 354 6 a a DT cord-023865-6rafp3x3 354 7 conserved conserve VBN cord-023865-6rafp3x3 354 8 neutralizing neutralize VBG cord-023865-6rafp3x3 354 9 epitope epitope NN cord-023865-6rafp3x3 354 10 from from IN cord-023865-6rafp3x3 354 11 the the DT cord-023865-6rafp3x3 354 12 spike spike NN cord-023865-6rafp3x3 354 13 protein protein NN cord-023865-6rafp3x3 354 14 of of IN cord-023865-6rafp3x3 354 15 SARS SARS NNP cord-023865-6rafp3x3 354 16 - - HYPH cord-023865-6rafp3x3 354 17 CoV CoV NNP cord-023865-6rafp3x3 354 18 , , , cord-023865-6rafp3x3 354 19 two two CD cord-023865-6rafp3x3 354 20 of of IN cord-023865-6rafp3x3 354 21 the the DT cord-023865-6rafp3x3 354 22 TH TH NNP cord-023865-6rafp3x3 354 23 cell cell NN cord-023865-6rafp3x3 354 24 epitope epitope NN cord-023865-6rafp3x3 354 25 - - HYPH cord-023865-6rafp3x3 354 26 bearing bear VBG cord-023865-6rafp3x3 354 27 peptides peptide NNS cord-023865-6rafp3x3 354 28 assisted assist VBN cord-023865-6rafp3x3 354 29 in in IN cord-023865-6rafp3x3 354 30 the the DT cord-023865-6rafp3x3 354 31 production production NN cord-023865-6rafp3x3 354 32 of of IN cord-023865-6rafp3x3 354 33 higher high JJR cord-023865-6rafp3x3 354 34 titer titer NN cord-023865-6rafp3x3 354 35 neutralizing neutralize VBG cord-023865-6rafp3x3 354 36 antibodies antibody NNS cord-023865-6rafp3x3 354 37 in in IN cord-023865-6rafp3x3 354 38 vivo vivo NN cord-023865-6rafp3x3 354 39 , , , cord-023865-6rafp3x3 354 40 in in IN cord-023865-6rafp3x3 354 41 comparision comparision NN cord-023865-6rafp3x3 354 42 to to TO cord-023865-6rafp3x3 354 43 spike spike NN cord-023865-6rafp3x3 354 44 epitope epitope NN cord-023865-6rafp3x3 354 45 alone alone RB cord-023865-6rafp3x3 354 46 or or CC cord-023865-6rafp3x3 354 47 its -PRON- PRP$ cord-023865-6rafp3x3 354 48 mixture mixture NN cord-023865-6rafp3x3 354 49 with with IN cord-023865-6rafp3x3 354 50 TH TH NNP cord-023865-6rafp3x3 354 51 epitope epitope NN cord-023865-6rafp3x3 354 52 of of IN cord-023865-6rafp3x3 355 1 N. N. NNP cord-023865-6rafp3x3 355 2 Thus thus RB cord-023865-6rafp3x3 355 3 , , , cord-023865-6rafp3x3 355 4 it -PRON- PRP cord-023865-6rafp3x3 355 5 is be VBZ cord-023865-6rafp3x3 355 6 practically practically RB cord-023865-6rafp3x3 355 7 possible possible JJ cord-023865-6rafp3x3 355 8 to to TO cord-023865-6rafp3x3 355 9 generate generate VB cord-023865-6rafp3x3 355 10 a a DT cord-023865-6rafp3x3 355 11 better well JJR cord-023865-6rafp3x3 355 12 immune immune JJ cord-023865-6rafp3x3 355 13 response response NN cord-023865-6rafp3x3 355 14 by by IN cord-023865-6rafp3x3 355 15 using use VBG cord-023865-6rafp3x3 355 16 a a DT cord-023865-6rafp3x3 355 17 fusion fusion NN cord-023865-6rafp3x3 355 18 of of IN cord-023865-6rafp3x3 355 19 N N NNP cord-023865-6rafp3x3 355 20 and and CC cord-023865-6rafp3x3 355 21 S S NNP cord-023865-6rafp3x3 355 22 protein protein NN cord-023865-6rafp3x3 355 23 . . . cord-023865-6rafp3x3 356 1 However however RB cord-023865-6rafp3x3 356 2 , , , cord-023865-6rafp3x3 356 3 the the DT cord-023865-6rafp3x3 356 4 TH TH NNP cord-023865-6rafp3x3 356 5 epitopes epitope NNS cord-023865-6rafp3x3 356 6 identified identify VBN cord-023865-6rafp3x3 356 7 in in IN cord-023865-6rafp3x3 356 8 their -PRON- PRP$ cord-023865-6rafp3x3 356 9 report report NN cord-023865-6rafp3x3 356 10 are be VBP cord-023865-6rafp3x3 356 11 specific specific JJ cord-023865-6rafp3x3 356 12 to to IN cord-023865-6rafp3x3 356 13 mouse mouse NN cord-023865-6rafp3x3 356 14 , , , cord-023865-6rafp3x3 356 15 and and CC cord-023865-6rafp3x3 356 16 will will MD cord-023865-6rafp3x3 356 17 therefore therefore RB cord-023865-6rafp3x3 356 18 not not RB cord-023865-6rafp3x3 356 19 be be VB cord-023865-6rafp3x3 356 20 useful useful JJ cord-023865-6rafp3x3 356 21 for for IN cord-023865-6rafp3x3 356 22 human human NN cord-023865-6rafp3x3 356 23 . . . cord-023865-6rafp3x3 357 1 Nevertheless nevertheless RB cord-023865-6rafp3x3 357 2 , , , cord-023865-6rafp3x3 357 3 their -PRON- PRP$ cord-023865-6rafp3x3 357 4 data data NN cord-023865-6rafp3x3 357 5 provides provide VBZ cord-023865-6rafp3x3 357 6 useful useful JJ cord-023865-6rafp3x3 357 7 information information NN cord-023865-6rafp3x3 357 8 for for IN cord-023865-6rafp3x3 357 9 the the DT cord-023865-6rafp3x3 357 10 design design NN cord-023865-6rafp3x3 357 11 of of IN cord-023865-6rafp3x3 357 12 peptide peptide NN cord-023865-6rafp3x3 357 13 - - HYPH cord-023865-6rafp3x3 357 14 based base VBN cord-023865-6rafp3x3 357 15 anti anti JJ cord-023865-6rafp3x3 357 16 - - JJ cord-023865-6rafp3x3 357 17 SARS SARS NNP cord-023865-6rafp3x3 357 18 - - HYPH cord-023865-6rafp3x3 357 19 CoV CoV NNP cord-023865-6rafp3x3 357 20 vaccines vaccine NNS cord-023865-6rafp3x3 357 21 . . . cord-023865-6rafp3x3 358 1 Another another DT cord-023865-6rafp3x3 358 2 interesting interesting JJ cord-023865-6rafp3x3 358 3 study study NN cord-023865-6rafp3x3 358 4 conducted conduct VBN cord-023865-6rafp3x3 358 5 by by IN cord-023865-6rafp3x3 358 6 Pei Pei NNP cord-023865-6rafp3x3 358 7 et et NNP cord-023865-6rafp3x3 358 8 al al NNP cord-023865-6rafp3x3 358 9 . . . cord-023865-6rafp3x3 359 1 ( ( -LRB- cord-023865-6rafp3x3 359 2 2005 2005 CD cord-023865-6rafp3x3 359 3 ) ) -RRB- cord-023865-6rafp3x3 359 4 reports report VBZ cord-023865-6rafp3x3 359 5 the the DT cord-023865-6rafp3x3 359 6 possible possible JJ cord-023865-6rafp3x3 359 7 use use NN cord-023865-6rafp3x3 359 8 of of IN cord-023865-6rafp3x3 359 9 the the DT cord-023865-6rafp3x3 359 10 N n NN cord-023865-6rafp3x3 359 11 - - HYPH cord-023865-6rafp3x3 359 12 protein protein NN cord-023865-6rafp3x3 359 13 as as IN cord-023865-6rafp3x3 359 14 a a DT cord-023865-6rafp3x3 359 15 mucosal mucosal JJ cord-023865-6rafp3x3 359 16 vaccine vaccine NN cord-023865-6rafp3x3 359 17 candidate candidate NN cord-023865-6rafp3x3 359 18 . . . cord-023865-6rafp3x3 360 1 They -PRON- PRP cord-023865-6rafp3x3 360 2 expressed express VBD cord-023865-6rafp3x3 360 3 the the DT cord-023865-6rafp3x3 360 4 N n NN cord-023865-6rafp3x3 360 5 - - HYPH cord-023865-6rafp3x3 360 6 protein protein NN cord-023865-6rafp3x3 360 7 in in IN cord-023865-6rafp3x3 360 8 Lactobacillus lactobacillus NN cord-023865-6rafp3x3 360 9 lactis lactis NN cord-023865-6rafp3x3 360 10 , , , cord-023865-6rafp3x3 360 11 which which WDT cord-023865-6rafp3x3 360 12 is be VBZ cord-023865-6rafp3x3 360 13 a a DT cord-023865-6rafp3x3 360 14 food food NN cord-023865-6rafp3x3 360 15 - - HYPH cord-023865-6rafp3x3 360 16 grade grade NN cord-023865-6rafp3x3 360 17 bacteria bacteria NNS cord-023865-6rafp3x3 360 18 , , , cord-023865-6rafp3x3 360 19 and and CC cord-023865-6rafp3x3 360 20 challenged challenge VBD cord-023865-6rafp3x3 360 21 the the DT cord-023865-6rafp3x3 360 22 mice mouse NNS cord-023865-6rafp3x3 360 23 either either CC cord-023865-6rafp3x3 360 24 orally orally RB cord-023865-6rafp3x3 360 25 or or CC cord-023865-6rafp3x3 360 26 intramucosally intramucosally RB cord-023865-6rafp3x3 360 27 . . . cord-023865-6rafp3x3 361 1 As as IN cord-023865-6rafp3x3 361 2 preliminary preliminary JJ cord-023865-6rafp3x3 361 3 evidence evidence NN cord-023865-6rafp3x3 361 4 , , , cord-023865-6rafp3x3 361 5 they -PRON- PRP cord-023865-6rafp3x3 361 6 were be VBD cord-023865-6rafp3x3 361 7 able able JJ cord-023865-6rafp3x3 361 8 to to TO cord-023865-6rafp3x3 361 9 observe observe VB cord-023865-6rafp3x3 361 10 significant significant JJ cord-023865-6rafp3x3 361 11 N n CD cord-023865-6rafp3x3 361 12 - - HYPH cord-023865-6rafp3x3 361 13 protein protein NN cord-023865-6rafp3x3 361 14 - - HYPH cord-023865-6rafp3x3 361 15 specific specific JJ cord-023865-6rafp3x3 361 16 IgG igg NN cord-023865-6rafp3x3 361 17 in in IN cord-023865-6rafp3x3 361 18 the the DT cord-023865-6rafp3x3 361 19 sera sera NNP cord-023865-6rafp3x3 361 20 of of IN cord-023865-6rafp3x3 361 21 orally orally RB cord-023865-6rafp3x3 361 22 challenged challenge VBN cord-023865-6rafp3x3 361 23 animals animal NNS cord-023865-6rafp3x3 361 24 . . . cord-023865-6rafp3x3 362 1 It -PRON- PRP cord-023865-6rafp3x3 362 2 is be VBZ cord-023865-6rafp3x3 362 3 a a DT cord-023865-6rafp3x3 362 4 significant significant JJ cord-023865-6rafp3x3 362 5 achievement achievement NN cord-023865-6rafp3x3 362 6 for for IN cord-023865-6rafp3x3 362 7 the the DT cord-023865-6rafp3x3 362 8 research research NN cord-023865-6rafp3x3 362 9 community community NN cord-023865-6rafp3x3 362 10 that that WDT cord-023865-6rafp3x3 362 11 , , , cord-023865-6rafp3x3 362 12 within within IN cord-023865-6rafp3x3 362 13 a a DT cord-023865-6rafp3x3 362 14 short short JJ cord-023865-6rafp3x3 362 15 span span NN cord-023865-6rafp3x3 362 16 of of IN cord-023865-6rafp3x3 362 17 time time NN cord-023865-6rafp3x3 362 18 , , , cord-023865-6rafp3x3 362 19 we -PRON- PRP cord-023865-6rafp3x3 362 20 have have VBP cord-023865-6rafp3x3 362 21 been be VBN cord-023865-6rafp3x3 362 22 able able JJ cord-023865-6rafp3x3 362 23 to to TO cord-023865-6rafp3x3 362 24 obtain obtain VB cord-023865-6rafp3x3 362 25 a a DT cord-023865-6rafp3x3 362 26 more more RBR cord-023865-6rafp3x3 362 27 - - HYPH cord-023865-6rafp3x3 362 28 or or CC cord-023865-6rafp3x3 362 29 - - HYPH cord-023865-6rafp3x3 362 30 less less RBR cord-023865-6rafp3x3 362 31 clear clear JJ cord-023865-6rafp3x3 362 32 understanding understanding NN cord-023865-6rafp3x3 362 33 regarding regard VBG cord-023865-6rafp3x3 362 34 the the DT cord-023865-6rafp3x3 362 35 structural structural JJ cord-023865-6rafp3x3 362 36 and and CC cord-023865-6rafp3x3 362 37 functional functional JJ cord-023865-6rafp3x3 362 38 properties property NNS cord-023865-6rafp3x3 362 39 of of IN cord-023865-6rafp3x3 362 40 the the DT cord-023865-6rafp3x3 362 41 N n NN cord-023865-6rafp3x3 362 42 - - HYPH cord-023865-6rafp3x3 362 43 protein protein NN cord-023865-6rafp3x3 362 44 . . . cord-023865-6rafp3x3 363 1 However however RB cord-023865-6rafp3x3 363 2 , , , cord-023865-6rafp3x3 363 3 it -PRON- PRP cord-023865-6rafp3x3 363 4 is be VBZ cord-023865-6rafp3x3 363 5 a a DT cord-023865-6rafp3x3 363 6 fact fact NN cord-023865-6rafp3x3 363 7 worth worth JJ cord-023865-6rafp3x3 363 8 mentioning mention VBG cord-023865-6rafp3x3 363 9 that that IN cord-023865-6rafp3x3 363 10 all all PDT cord-023865-6rafp3x3 363 11 the the DT cord-023865-6rafp3x3 363 12 studies study NNS cord-023865-6rafp3x3 363 13 done do VBN cord-023865-6rafp3x3 363 14 here here RB cord-023865-6rafp3x3 363 15 were be VBD cord-023865-6rafp3x3 363 16 performed perform VBN cord-023865-6rafp3x3 363 17 with with IN cord-023865-6rafp3x3 363 18 in in IN cord-023865-6rafp3x3 363 19 - - HYPH cord-023865-6rafp3x3 363 20 vitro vitro FW cord-023865-6rafp3x3 363 21 experiments experiment NNS cord-023865-6rafp3x3 363 22 , , , cord-023865-6rafp3x3 363 23 using use VBG cord-023865-6rafp3x3 363 24 recombinantly recombinantly RB cord-023865-6rafp3x3 363 25 expressed express VBD cord-023865-6rafp3x3 363 26 N n NN cord-023865-6rafp3x3 363 27 - - HYPH cord-023865-6rafp3x3 363 28 protein protein NN cord-023865-6rafp3x3 363 29 , , , cord-023865-6rafp3x3 363 30 in in IN cord-023865-6rafp3x3 363 31 isolation isolation NN cord-023865-6rafp3x3 363 32 . . . cord-023865-6rafp3x3 364 1 So so RB cord-023865-6rafp3x3 364 2 at at IN cord-023865-6rafp3x3 364 3 present present JJ cord-023865-6rafp3x3 364 4 , , , cord-023865-6rafp3x3 364 5 all all DT cord-023865-6rafp3x3 364 6 we -PRON- PRP cord-023865-6rafp3x3 364 7 can can MD cord-023865-6rafp3x3 364 8 conclude conclude VB cord-023865-6rafp3x3 364 9 is be VBZ cord-023865-6rafp3x3 364 10 that that IN cord-023865-6rafp3x3 364 11 the the DT cord-023865-6rafp3x3 364 12 N n NN cord-023865-6rafp3x3 364 13 - - HYPH cord-023865-6rafp3x3 364 14 protein protein NN cord-023865-6rafp3x3 364 15 per per FW cord-023865-6rafp3x3 364 16 se se FW cord-023865-6rafp3x3 364 17 has have VBZ cord-023865-6rafp3x3 364 18 the the DT cord-023865-6rafp3x3 364 19 physical physical JJ cord-023865-6rafp3x3 364 20 ability ability NN cord-023865-6rafp3x3 364 21 to to TO cord-023865-6rafp3x3 364 22 perform perform VB cord-023865-6rafp3x3 364 23 the the DT cord-023865-6rafp3x3 364 24 above above RB cord-023865-6rafp3x3 364 25 described describe VBN cord-023865-6rafp3x3 364 26 functions function NNS cord-023865-6rafp3x3 364 27 , , , cord-023865-6rafp3x3 364 28 in in IN cord-023865-6rafp3x3 364 29 other other JJ cord-023865-6rafp3x3 364 30 words word NNS cord-023865-6rafp3x3 364 31 N n NN cord-023865-6rafp3x3 364 32 - - HYPH cord-023865-6rafp3x3 364 33 protein protein NN cord-023865-6rafp3x3 364 34 does do VBZ cord-023865-6rafp3x3 364 35 bear bear VB cord-023865-6rafp3x3 364 36 the the DT cord-023865-6rafp3x3 364 37 necessary necessary JJ cord-023865-6rafp3x3 364 38 signature signature NN cord-023865-6rafp3x3 364 39 sequence sequence NN cord-023865-6rafp3x3 364 40 or or CC cord-023865-6rafp3x3 364 41 motifs motif NNS cord-023865-6rafp3x3 364 42 or or CC cord-023865-6rafp3x3 364 43 conformation conformation NN cord-023865-6rafp3x3 364 44 to to TO cord-023865-6rafp3x3 364 45 perform perform VB cord-023865-6rafp3x3 364 46 these these DT cord-023865-6rafp3x3 364 47 functions function NNS cord-023865-6rafp3x3 364 48 under under IN cord-023865-6rafp3x3 364 49 suitable suitable JJ cord-023865-6rafp3x3 364 50 circumstances circumstance NNS cord-023865-6rafp3x3 364 51 . . . cord-023865-6rafp3x3 365 1 Whether whether IN cord-023865-6rafp3x3 365 2 a a DT cord-023865-6rafp3x3 365 3 similar similar JJ cord-023865-6rafp3x3 365 4 event event NN cord-023865-6rafp3x3 365 5 is be VBZ cord-023865-6rafp3x3 365 6 recapitulated recapitulate VBN cord-023865-6rafp3x3 365 7 in in IN cord-023865-6rafp3x3 365 8 vivo vivo NN cord-023865-6rafp3x3 365 9 during during IN cord-023865-6rafp3x3 365 10 viral viral JJ cord-023865-6rafp3x3 365 11 infection infection NN cord-023865-6rafp3x3 365 12 will will MD cord-023865-6rafp3x3 365 13 be be VB cord-023865-6rafp3x3 365 14 dependent dependent JJ cord-023865-6rafp3x3 365 15 on on IN cord-023865-6rafp3x3 365 16 several several JJ cord-023865-6rafp3x3 365 17 criteria criterion NNS cord-023865-6rafp3x3 365 18 : : : cord-023865-6rafp3x3 365 19 ( ( -LRB- cord-023865-6rafp3x3 365 20 1 1 LS cord-023865-6rafp3x3 365 21 ) ) -RRB- cord-023865-6rafp3x3 365 22 the the DT cord-023865-6rafp3x3 365 23 net net JJ cord-023865-6rafp3x3 365 24 effect effect NN cord-023865-6rafp3x3 365 25 of of IN cord-023865-6rafp3x3 365 26 other other JJ cord-023865-6rafp3x3 365 27 viral viral JJ cord-023865-6rafp3x3 365 28 factors factor NNS cord-023865-6rafp3x3 365 29 on on IN cord-023865-6rafp3x3 365 30 the the DT cord-023865-6rafp3x3 365 31 activity activity NN cord-023865-6rafp3x3 365 32 of of IN cord-023865-6rafp3x3 365 33 N n NN cord-023865-6rafp3x3 365 34 - - HYPH cord-023865-6rafp3x3 365 35 protein protein NN cord-023865-6rafp3x3 365 36 , , , cord-023865-6rafp3x3 365 37 ( ( -LRB- cord-023865-6rafp3x3 365 38 2 2 LS cord-023865-6rafp3x3 365 39 ) ) -RRB- cord-023865-6rafp3x3 365 40 the the DT cord-023865-6rafp3x3 365 41 net net JJ cord-023865-6rafp3x3 365 42 translation translation NN cord-023865-6rafp3x3 365 43 and and CC cord-023865-6rafp3x3 365 44 turnover turnover NN cord-023865-6rafp3x3 365 45 rate rate NN cord-023865-6rafp3x3 365 46 of of IN cord-023865-6rafp3x3 365 47 N n NN cord-023865-6rafp3x3 365 48 - - HYPH cord-023865-6rafp3x3 365 49 protein protein NN cord-023865-6rafp3x3 365 50 , , , cord-023865-6rafp3x3 365 51 ( ( -LRB- cord-023865-6rafp3x3 365 52 3 3 LS cord-023865-6rafp3x3 365 53 ) ) -RRB- cord-023865-6rafp3x3 365 54 a a DT cord-023865-6rafp3x3 365 55 conducive conducive JJ cord-023865-6rafp3x3 365 56 intracellular intracellular JJ cord-023865-6rafp3x3 365 57 milieu milieu NN cord-023865-6rafp3x3 365 58 , , , cord-023865-6rafp3x3 365 59 and and CC cord-023865-6rafp3x3 365 60 ( ( -LRB- cord-023865-6rafp3x3 365 61 4 4 LS cord-023865-6rafp3x3 365 62 ) ) -RRB- cord-023865-6rafp3x3 365 63 the the DT cord-023865-6rafp3x3 365 64 net net JJ cord-023865-6rafp3x3 365 65 modulation modulation NN cord-023865-6rafp3x3 365 66 of of IN cord-023865-6rafp3x3 365 67 an an DT cord-023865-6rafp3x3 365 68 already already RB cord-023865-6rafp3x3 365 69 skewed skewed JJ cord-023865-6rafp3x3 365 70 cellular cellular JJ cord-023865-6rafp3x3 365 71 pathway pathway NN cord-023865-6rafp3x3 365 72 by by IN cord-023865-6rafp3x3 365 73 other other JJ cord-023865-6rafp3x3 365 74 viral viral JJ cord-023865-6rafp3x3 365 75 factors factor NNS cord-023865-6rafp3x3 365 76 . . . cord-023865-6rafp3x3 366 1 Hence hence RB cord-023865-6rafp3x3 366 2 , , , cord-023865-6rafp3x3 366 3 it -PRON- PRP cord-023865-6rafp3x3 366 4 will will MD cord-023865-6rafp3x3 366 5 be be VB cord-023865-6rafp3x3 366 6 interesting interesting JJ cord-023865-6rafp3x3 366 7 to to TO cord-023865-6rafp3x3 366 8 reevaluate reevaluate VB cord-023865-6rafp3x3 366 9 the the DT cord-023865-6rafp3x3 366 10 properties property NNS cord-023865-6rafp3x3 366 11 of of IN cord-023865-6rafp3x3 366 12 N n NN cord-023865-6rafp3x3 366 13 - - HYPH cord-023865-6rafp3x3 366 14 protein protein NN cord-023865-6rafp3x3 366 15 in in IN cord-023865-6rafp3x3 366 16 a a DT cord-023865-6rafp3x3 366 17 SARS SARS NNP cord-023865-6rafp3x3 366 18 - - HYPH cord-023865-6rafp3x3 366 19 CoV CoV NNP cord-023865-6rafp3x3 366 20 infection infection NN cord-023865-6rafp3x3 366 21 model model NN cord-023865-6rafp3x3 366 22 . . . cord-023865-6rafp3x3 367 1 However however RB cord-023865-6rafp3x3 367 2 , , , cord-023865-6rafp3x3 367 3 owing owe VBG cord-023865-6rafp3x3 367 4 to to IN cord-023865-6rafp3x3 367 5 the the DT cord-023865-6rafp3x3 367 6 limited limited JJ cord-023865-6rafp3x3 367 7 user user NN cord-023865-6rafp3x3 367 8 - - HYPH cord-023865-6rafp3x3 367 9 friendliness friendliness NN cord-023865-6rafp3x3 367 10 and and CC cord-023865-6rafp3x3 367 11 accessibility accessibility NN cord-023865-6rafp3x3 367 12 of of IN cord-023865-6rafp3x3 367 13 an an DT cord-023865-6rafp3x3 367 14 infection infection NN cord-023865-6rafp3x3 367 15 system system NN cord-023865-6rafp3x3 367 16 , , , cord-023865-6rafp3x3 367 17 we -PRON- PRP cord-023865-6rafp3x3 367 18 must must MD cord-023865-6rafp3x3 367 19 probably probably RB cord-023865-6rafp3x3 367 20 still still RB cord-023865-6rafp3x3 367 21 resort resort VB cord-023865-6rafp3x3 367 22 to to IN cord-023865-6rafp3x3 367 23 in in FW cord-023865-6rafp3x3 367 24 vitro vitro FW cord-023865-6rafp3x3 367 25 systems system NNS cord-023865-6rafp3x3 367 26 for for IN cord-023865-6rafp3x3 367 27 further further JJ cord-023865-6rafp3x3 367 28 analysis analysis NN cord-023865-6rafp3x3 367 29 of of IN cord-023865-6rafp3x3 367 30 the the DT cord-023865-6rafp3x3 367 31 characteristics characteristic NNS cord-023865-6rafp3x3 367 32 of of IN cord-023865-6rafp3x3 367 33 N n NN cord-023865-6rafp3x3 367 34 - - HYPH cord-023865-6rafp3x3 367 35 protein protein NN cord-023865-6rafp3x3 367 36 . . . cord-023865-6rafp3x3 368 1 One one CD cord-023865-6rafp3x3 368 2 of of IN cord-023865-6rafp3x3 368 3 the the DT cord-023865-6rafp3x3 368 4 better well JJR cord-023865-6rafp3x3 368 5 experimental experimental JJ cord-023865-6rafp3x3 368 6 systems system NNS cord-023865-6rafp3x3 368 7 has have VBZ cord-023865-6rafp3x3 368 8 already already RB cord-023865-6rafp3x3 368 9 been be VBN cord-023865-6rafp3x3 368 10 established establish VBN cord-023865-6rafp3x3 368 11 by by IN cord-023865-6rafp3x3 368 12 Chang Chang NNP cord-023865-6rafp3x3 368 13 's 's POS cord-023865-6rafp3x3 368 14 laboratory laboratory NN cord-023865-6rafp3x3 368 15 ( ( -LRB- cord-023865-6rafp3x3 368 16 Hsieh Hsieh NNP cord-023865-6rafp3x3 368 17 et et NNP cord-023865-6rafp3x3 368 18 al al NNP cord-023865-6rafp3x3 368 19 . . NNP cord-023865-6rafp3x3 368 20 2005 2005 CD cord-023865-6rafp3x3 368 21 ) ) -RRB- cord-023865-6rafp3x3 368 22 , , , cord-023865-6rafp3x3 368 23 in in IN cord-023865-6rafp3x3 368 24 which which WDT cord-023865-6rafp3x3 368 25 all all PDT cord-023865-6rafp3x3 368 26 the the DT cord-023865-6rafp3x3 368 27 structural structural JJ cord-023865-6rafp3x3 368 28 proteins protein NNS cord-023865-6rafp3x3 368 29 were be VBD cord-023865-6rafp3x3 368 30 coexpressed coexpresse VBN cord-023865-6rafp3x3 368 31 to to TO cord-023865-6rafp3x3 368 32 form form VB cord-023865-6rafp3x3 368 33 VLP VLP NNP cord-023865-6rafp3x3 368 34 in in IN cord-023865-6rafp3x3 368 35 293 293 CD cord-023865-6rafp3x3 368 36 T T NNP cord-023865-6rafp3x3 368 37 cells cell NNS cord-023865-6rafp3x3 368 38 . . . cord-023865-6rafp3x3 369 1 If if IN cord-023865-6rafp3x3 369 2 this this DT cord-023865-6rafp3x3 369 3 system system NN cord-023865-6rafp3x3 369 4 can can MD cord-023865-6rafp3x3 369 5 be be VB cord-023865-6rafp3x3 369 6 further further RB cord-023865-6rafp3x3 369 7 improved improve VBN cord-023865-6rafp3x3 369 8 to to TO cord-023865-6rafp3x3 369 9 optimize optimize VB cord-023865-6rafp3x3 369 10 the the DT cord-023865-6rafp3x3 369 11 rate rate NN cord-023865-6rafp3x3 369 12 of of IN cord-023865-6rafp3x3 369 13 synthesis synthesis NN cord-023865-6rafp3x3 369 14 of of IN cord-023865-6rafp3x3 369 15 these these DT cord-023865-6rafp3x3 369 16 different different JJ cord-023865-6rafp3x3 369 17 proteins protein NNS cord-023865-6rafp3x3 369 18 to to IN cord-023865-6rafp3x3 369 19 a a DT cord-023865-6rafp3x3 369 20 level level NN cord-023865-6rafp3x3 369 21 near near IN cord-023865-6rafp3x3 369 22 that that DT cord-023865-6rafp3x3 369 23 in in IN cord-023865-6rafp3x3 369 24 vivo vivo NN cord-023865-6rafp3x3 369 25 , , , cord-023865-6rafp3x3 369 26 it -PRON- PRP cord-023865-6rafp3x3 369 27 will will MD cord-023865-6rafp3x3 369 28 at at IN cord-023865-6rafp3x3 369 29 least least JJS cord-023865-6rafp3x3 369 30 enable enable VB cord-023865-6rafp3x3 369 31 us -PRON- PRP cord-023865-6rafp3x3 369 32 to to TO cord-023865-6rafp3x3 369 33 study study VB cord-023865-6rafp3x3 369 34 the the DT cord-023865-6rafp3x3 369 35 net net JJ cord-023865-6rafp3x3 369 36 effect effect NN cord-023865-6rafp3x3 369 37 of of IN cord-023865-6rafp3x3 369 38 the the DT cord-023865-6rafp3x3 369 39 N n NN cord-023865-6rafp3x3 369 40 - - HYPH cord-023865-6rafp3x3 369 41 protein protein NN cord-023865-6rafp3x3 369 42 with with IN cord-023865-6rafp3x3 369 43 respect respect NN cord-023865-6rafp3x3 369 44 to to IN cord-023865-6rafp3x3 369 45 other other JJ cord-023865-6rafp3x3 369 46 viral viral JJ cord-023865-6rafp3x3 369 47 proteins protein NNS cord-023865-6rafp3x3 369 48 . . . cord-023865-6rafp3x3 370 1 Further further JJ cord-023865-6rafp3x3 370 2 establishment establishment NN cord-023865-6rafp3x3 370 3 of of IN cord-023865-6rafp3x3 370 4 a a DT cord-023865-6rafp3x3 370 5 replicon replicon NN cord-023865-6rafp3x3 370 6 system system NN cord-023865-6rafp3x3 370 7 may may MD cord-023865-6rafp3x3 370 8 also also RB cord-023865-6rafp3x3 370 9 be be VB cord-023865-6rafp3x3 370 10 helpful helpful JJ cord-023865-6rafp3x3 370 11 . . . cord-023865-6rafp3x3 371 1 In in IN cord-023865-6rafp3x3 371 2 addition addition NN cord-023865-6rafp3x3 371 3 , , , cord-023865-6rafp3x3 371 4 some some DT cord-023865-6rafp3x3 371 5 of of IN cord-023865-6rafp3x3 371 6 the the DT cord-023865-6rafp3x3 371 7 interesting interesting JJ cord-023865-6rafp3x3 371 8 preliminary preliminary JJ cord-023865-6rafp3x3 371 9 observations observation NNS cord-023865-6rafp3x3 371 10 reported report VBN cord-023865-6rafp3x3 371 11 by by IN cord-023865-6rafp3x3 371 12 several several JJ cord-023865-6rafp3x3 371 13 laboratories laboratory NNS cord-023865-6rafp3x3 371 14 need need VBP cord-023865-6rafp3x3 371 15 to to TO cord-023865-6rafp3x3 371 16 be be VB cord-023865-6rafp3x3 371 17 analyzed analyze VBN cord-023865-6rafp3x3 371 18 in in IN cord-023865-6rafp3x3 371 19 detail detail NN cord-023865-6rafp3x3 371 20 . . . cord-023865-6rafp3x3 372 1 To to TO cord-023865-6rafp3x3 372 2 begin begin VB cord-023865-6rafp3x3 372 3 with with IN cord-023865-6rafp3x3 372 4 , , , cord-023865-6rafp3x3 372 5 the the DT cord-023865-6rafp3x3 372 6 reported report VBN cord-023865-6rafp3x3 372 7 interaction interaction NN cord-023865-6rafp3x3 372 8 of of IN cord-023865-6rafp3x3 372 9 the the DT cord-023865-6rafp3x3 372 10 N n NN cord-023865-6rafp3x3 372 11 - - HYPH cord-023865-6rafp3x3 372 12 protein protein NN cord-023865-6rafp3x3 372 13 with with IN cord-023865-6rafp3x3 372 14 the the DT cord-023865-6rafp3x3 372 15 genomic genomic JJ cord-023865-6rafp3x3 372 16 RNA RNA NNP cord-023865-6rafp3x3 372 17 packaging packaging NN cord-023865-6rafp3x3 372 18 signal signal NN cord-023865-6rafp3x3 372 19 needs need VBZ cord-023865-6rafp3x3 372 20 to to TO cord-023865-6rafp3x3 372 21 be be VB cord-023865-6rafp3x3 372 22 further further RB cord-023865-6rafp3x3 372 23 characterized characterize VBN cord-023865-6rafp3x3 372 24 and and CC cord-023865-6rafp3x3 372 25 mapped map VBN cord-023865-6rafp3x3 372 26 . . . cord-023865-6rafp3x3 373 1 Since since IN cord-023865-6rafp3x3 373 2 the the DT cord-023865-6rafp3x3 373 3 oligomerization oligomerization NN cord-023865-6rafp3x3 373 4 domain domain NN cord-023865-6rafp3x3 373 5 and and CC cord-023865-6rafp3x3 373 6 the the DT cord-023865-6rafp3x3 373 7 RNA RNA NNP cord-023865-6rafp3x3 373 8 binding binding NN cord-023865-6rafp3x3 373 9 regions region NNS cord-023865-6rafp3x3 373 10 of of IN cord-023865-6rafp3x3 373 11 the the DT cord-023865-6rafp3x3 373 12 N n CD cord-023865-6rafp3x3 373 13 - - HYPH cord-023865-6rafp3x3 373 14 protein protein NN cord-023865-6rafp3x3 373 15 overlap overlap VBP cord-023865-6rafp3x3 373 16 with with IN cord-023865-6rafp3x3 373 17 each each DT cord-023865-6rafp3x3 373 18 other other JJ cord-023865-6rafp3x3 373 19 , , , cord-023865-6rafp3x3 373 20 the the DT cord-023865-6rafp3x3 373 21 suggested suggest VBN cord-023865-6rafp3x3 373 22 possibility possibility NN cord-023865-6rafp3x3 373 23 of of IN cord-023865-6rafp3x3 373 24 regulated regulated JJ cord-023865-6rafp3x3 373 25 genome genome NN cord-023865-6rafp3x3 373 26 incorporation incorporation NN cord-023865-6rafp3x3 373 27 and and CC cord-023865-6rafp3x3 373 28 capsid capsid NN cord-023865-6rafp3x3 373 29 assembly assembly NN cord-023865-6rafp3x3 373 30 should should MD cord-023865-6rafp3x3 373 31 be be VB cord-023865-6rafp3x3 373 32 further further RB cord-023865-6rafp3x3 373 33 characterized characterize VBN cord-023865-6rafp3x3 373 34 with with IN cord-023865-6rafp3x3 373 35 the the DT cord-023865-6rafp3x3 373 36 aid aid NN cord-023865-6rafp3x3 373 37 of of IN cord-023865-6rafp3x3 373 38 a a DT cord-023865-6rafp3x3 373 39 replicon replicon NN cord-023865-6rafp3x3 373 40 system system NN cord-023865-6rafp3x3 373 41 or or CC cord-023865-6rafp3x3 373 42 a a DT cord-023865-6rafp3x3 373 43 particle particle NN cord-023865-6rafp3x3 373 44 assembly assembly NN cord-023865-6rafp3x3 373 45 system system NN cord-023865-6rafp3x3 373 46 . . . cord-023865-6rafp3x3 374 1 In in IN cord-023865-6rafp3x3 374 2 addition addition NN cord-023865-6rafp3x3 374 3 , , , cord-023865-6rafp3x3 374 4 the the DT cord-023865-6rafp3x3 374 5 reported report VBN cord-023865-6rafp3x3 374 6 ability ability NN cord-023865-6rafp3x3 374 7 of of IN cord-023865-6rafp3x3 374 8 the the DT cord-023865-6rafp3x3 374 9 N n NN cord-023865-6rafp3x3 374 10 - - HYPH cord-023865-6rafp3x3 374 11 protein protein NN cord-023865-6rafp3x3 374 12 to to TO cord-023865-6rafp3x3 374 13 modulate modulate VB cord-023865-6rafp3x3 374 14 different different JJ cord-023865-6rafp3x3 374 15 cellular cellular JJ cord-023865-6rafp3x3 374 16 pathways pathway NNS cord-023865-6rafp3x3 374 17 should should MD cord-023865-6rafp3x3 374 18 be be VB cord-023865-6rafp3x3 374 19 further further RB cord-023865-6rafp3x3 374 20 characterized characterize VBN cord-023865-6rafp3x3 374 21 in in IN cord-023865-6rafp3x3 374 22 the the DT cord-023865-6rafp3x3 374 23 particle particle NN cord-023865-6rafp3x3 374 24 assembly assembly NN cord-023865-6rafp3x3 374 25 system system NN cord-023865-6rafp3x3 374 26 or or CC cord-023865-6rafp3x3 374 27 at at IN cord-023865-6rafp3x3 374 28 least least JJS cord-023865-6rafp3x3 374 29 in in IN cord-023865-6rafp3x3 374 30 the the DT cord-023865-6rafp3x3 374 31 presence presence NN cord-023865-6rafp3x3 374 32 of of IN cord-023865-6rafp3x3 374 33 other other JJ cord-023865-6rafp3x3 374 34 viral viral JJ cord-023865-6rafp3x3 374 35 accessory accessory NN cord-023865-6rafp3x3 374 36 proteins protein NNS cord-023865-6rafp3x3 374 37 . . . cord-023865-6rafp3x3 375 1 The the DT cord-023865-6rafp3x3 375 2 most most RBS cord-023865-6rafp3x3 375 3 unique unique JJ cord-023865-6rafp3x3 375 4 and and CC cord-023865-6rafp3x3 375 5 significant significant JJ cord-023865-6rafp3x3 375 6 property property NN cord-023865-6rafp3x3 375 7 of of IN cord-023865-6rafp3x3 375 8 the the DT cord-023865-6rafp3x3 375 9 N N NNP cord-023865-6rafp3x3 375 10 - - HYPH cord-023865-6rafp3x3 375 11 protein protein NN cord-023865-6rafp3x3 375 12 revealed reveal VBN cord-023865-6rafp3x3 375 13 by by IN cord-023865-6rafp3x3 375 14 preliminary preliminary JJ cord-023865-6rafp3x3 375 15 studies study NNS cord-023865-6rafp3x3 375 16 is be VBZ cord-023865-6rafp3x3 375 17 its -PRON- PRP$ cord-023865-6rafp3x3 375 18 ability ability NN cord-023865-6rafp3x3 375 19 to to TO cord-023865-6rafp3x3 375 20 act act VB cord-023865-6rafp3x3 375 21 as as IN cord-023865-6rafp3x3 375 22 a a DT cord-023865-6rafp3x3 375 23 sequence sequence NN cord-023865-6rafp3x3 375 24 - - HYPH cord-023865-6rafp3x3 375 25 specific specific JJ cord-023865-6rafp3x3 375 26 DNA dna NN cord-023865-6rafp3x3 375 27 binding binding NN cord-023865-6rafp3x3 375 28 factor factor NN cord-023865-6rafp3x3 375 29 . . . cord-023865-6rafp3x3 376 1 It -PRON- PRP cord-023865-6rafp3x3 376 2 has have VBZ cord-023865-6rafp3x3 376 3 been be VBN cord-023865-6rafp3x3 376 4 shown show VBN cord-023865-6rafp3x3 376 5 to to TO cord-023865-6rafp3x3 376 6 bind bind VB cord-023865-6rafp3x3 376 7 the the DT cord-023865-6rafp3x3 376 8 NFkB NFkB NNP cord-023865-6rafp3x3 376 9 response response NN cord-023865-6rafp3x3 376 10 element element NN cord-023865-6rafp3x3 376 11 of of IN cord-023865-6rafp3x3 376 12 COX2 cox2 JJ cord-023865-6rafp3x3 376 13 promoter promoter NN cord-023865-6rafp3x3 376 14 and and CC cord-023865-6rafp3x3 376 15 to to TO cord-023865-6rafp3x3 376 16 enhance enhance VB cord-023865-6rafp3x3 376 17 COX2 cox2 JJ cord-023865-6rafp3x3 376 18 gene gene NN cord-023865-6rafp3x3 376 19 expression expression NN cord-023865-6rafp3x3 376 20 . . . cord-023865-6rafp3x3 377 1 This this DT cord-023865-6rafp3x3 377 2 activity activity NN cord-023865-6rafp3x3 377 3 may may MD cord-023865-6rafp3x3 377 4 be be VB cord-023865-6rafp3x3 377 5 further further RB cord-023865-6rafp3x3 377 6 empowering empower VBG cord-023865-6rafp3x3 377 7 the the DT cord-023865-6rafp3x3 377 8 N n NN cord-023865-6rafp3x3 377 9 - - HYPH cord-023865-6rafp3x3 377 10 protein protein NN cord-023865-6rafp3x3 377 11 to to TO cord-023865-6rafp3x3 377 12 manipulate manipulate VB cord-023865-6rafp3x3 377 13 the the DT cord-023865-6rafp3x3 377 14 entire entire JJ cord-023865-6rafp3x3 377 15 gene gene NN cord-023865-6rafp3x3 377 16 expression expression NN cord-023865-6rafp3x3 377 17 programme programme NN cord-023865-6rafp3x3 377 18 of of IN cord-023865-6rafp3x3 377 19 the the DT cord-023865-6rafp3x3 377 20 infected infected JJ cord-023865-6rafp3x3 377 21 cell cell NN cord-023865-6rafp3x3 377 22 . . . cord-023865-6rafp3x3 378 1 Therefore therefore RB cord-023865-6rafp3x3 378 2 , , , cord-023865-6rafp3x3 378 3 studies study NNS cord-023865-6rafp3x3 378 4 should should MD cord-023865-6rafp3x3 378 5 be be VB cord-023865-6rafp3x3 378 6 initiated initiate VBN cord-023865-6rafp3x3 378 7 to to TO cord-023865-6rafp3x3 378 8 analyze analyze VB cord-023865-6rafp3x3 378 9 this this DT cord-023865-6rafp3x3 378 10 phenomenon phenomenon NN cord-023865-6rafp3x3 378 11 in in IN cord-023865-6rafp3x3 378 12 detail detail NN cord-023865-6rafp3x3 378 13 . . . cord-023865-6rafp3x3 379 1 It -PRON- PRP cord-023865-6rafp3x3 379 2 seems seem VBZ cord-023865-6rafp3x3 379 3 to to TO cord-023865-6rafp3x3 379 4 deserve deserve VB cord-023865-6rafp3x3 379 5 so so RB cord-023865-6rafp3x3 379 6 much much JJ cord-023865-6rafp3x3 379 7 attention attention NN cord-023865-6rafp3x3 379 8 because because IN cord-023865-6rafp3x3 379 9 another another DT cord-023865-6rafp3x3 379 10 study study NN cord-023865-6rafp3x3 379 11 done do VBN cord-023865-6rafp3x3 379 12 by by IN cord-023865-6rafp3x3 379 13 Palese Palese NNP cord-023865-6rafp3x3 379 14 's 's POS cord-023865-6rafp3x3 379 15 laboratory laboratory NN cord-023865-6rafp3x3 379 16 has have VBZ cord-023865-6rafp3x3 379 17 proved prove VBN cord-023865-6rafp3x3 379 18 the the DT cord-023865-6rafp3x3 379 19 ability ability NN cord-023865-6rafp3x3 379 20 of of IN cord-023865-6rafp3x3 379 21 the the DT cord-023865-6rafp3x3 379 22 N n NN cord-023865-6rafp3x3 379 23 - - HYPH cord-023865-6rafp3x3 379 24 protein protein NN cord-023865-6rafp3x3 379 25 to to TO cord-023865-6rafp3x3 379 26 inhibit inhibit VB cord-023865-6rafp3x3 379 27 NFkB nfkb JJ cord-023865-6rafp3x3 379 28 activity activity NN cord-023865-6rafp3x3 379 29 , , , cord-023865-6rafp3x3 379 30 which which WDT cord-023865-6rafp3x3 379 31 results result VBZ cord-023865-6rafp3x3 379 32 in in IN cord-023865-6rafp3x3 379 33 inhibition inhibition NN cord-023865-6rafp3x3 379 34 of of IN cord-023865-6rafp3x3 379 35 IFN IFN NNP cord-023865-6rafp3x3 379 36 synthesis synthesis NN cord-023865-6rafp3x3 379 37 . . . cord-023865-6rafp3x3 380 1 Further further RB cord-023865-6rafp3x3 380 2 , , , cord-023865-6rafp3x3 380 3 Liao Liao NNP cord-023865-6rafp3x3 380 4 et et NNP cord-023865-6rafp3x3 380 5 al al NNP cord-023865-6rafp3x3 380 6 . . . cord-023865-6rafp3x3 381 1 ( ( -LRB- cord-023865-6rafp3x3 381 2 2005 2005 CD cord-023865-6rafp3x3 381 3 ) ) -RRB- cord-023865-6rafp3x3 381 4 have have VBP cord-023865-6rafp3x3 381 5 reported report VBN cord-023865-6rafp3x3 381 6 the the DT cord-023865-6rafp3x3 381 7 activation activation NN cord-023865-6rafp3x3 381 8 of of IN cord-023865-6rafp3x3 381 9 NFkB NFkB NNP cord-023865-6rafp3x3 381 10 by by IN cord-023865-6rafp3x3 381 11 N n NN cord-023865-6rafp3x3 381 12 - - HYPH cord-023865-6rafp3x3 381 13 protein protein NN cord-023865-6rafp3x3 381 14 in in IN cord-023865-6rafp3x3 381 15 Vero Vero NNP cord-023865-6rafp3x3 381 16 E6 E6 NNP cord-023865-6rafp3x3 381 17 cells cell NNS cord-023865-6rafp3x3 381 18 and and CC cord-023865-6rafp3x3 381 19 He -PRON- PRP cord-023865-6rafp3x3 381 20 et et FW cord-023865-6rafp3x3 381 21 al al NNP cord-023865-6rafp3x3 381 22 . . . cord-023865-6rafp3x3 382 1 ( ( -LRB- cord-023865-6rafp3x3 382 2 2005 2005 CD cord-023865-6rafp3x3 382 3 ) ) -RRB- cord-023865-6rafp3x3 382 4 failed fail VBD cord-023865-6rafp3x3 382 5 to to TO cord-023865-6rafp3x3 382 6 detect detect VB cord-023865-6rafp3x3 382 7 any any DT cord-023865-6rafp3x3 382 8 change change NN cord-023865-6rafp3x3 382 9 in in IN cord-023865-6rafp3x3 382 10 NFkB NFkB NNP cord-023865-6rafp3x3 382 11 activity activity NN cord-023865-6rafp3x3 382 12 in in IN cord-023865-6rafp3x3 382 13 the the DT cord-023865-6rafp3x3 382 14 same same JJ cord-023865-6rafp3x3 382 15 cells cell NNS cord-023865-6rafp3x3 382 16 . . . cord-023865-6rafp3x3 383 1 Therefore therefore RB cord-023865-6rafp3x3 383 2 it -PRON- PRP cord-023865-6rafp3x3 383 3 needs need VBZ cord-023865-6rafp3x3 383 4 to to TO cord-023865-6rafp3x3 383 5 be be VB cord-023865-6rafp3x3 383 6 clarified clarify VBN cord-023865-6rafp3x3 383 7 whether whether IN cord-023865-6rafp3x3 383 8 N n NN cord-023865-6rafp3x3 383 9 - - HYPH cord-023865-6rafp3x3 383 10 protein protein NN cord-023865-6rafp3x3 383 11 enhances enhance VBZ cord-023865-6rafp3x3 383 12 NFkB nfkb JJ cord-023865-6rafp3x3 383 13 activity activity NN cord-023865-6rafp3x3 383 14 and and CC cord-023865-6rafp3x3 383 15 , , , cord-023865-6rafp3x3 383 16 if if IN cord-023865-6rafp3x3 383 17 so so RB cord-023865-6rafp3x3 383 18 , , , cord-023865-6rafp3x3 383 19 whether whether IN cord-023865-6rafp3x3 383 20 upregulation upregulation NN cord-023865-6rafp3x3 383 21 of of IN cord-023865-6rafp3x3 383 22 COX2 cox2 JJ cord-023865-6rafp3x3 383 23 transcription transcription NN cord-023865-6rafp3x3 383 24 by by IN cord-023865-6rafp3x3 383 25 direct direct JJ cord-023865-6rafp3x3 383 26 DNA dna NN cord-023865-6rafp3x3 383 27 binding binding NN cord-023865-6rafp3x3 383 28 is be VBZ cord-023865-6rafp3x3 383 29 a a DT cord-023865-6rafp3x3 383 30 property property NN cord-023865-6rafp3x3 383 31 specific specific JJ cord-023865-6rafp3x3 383 32 to to IN cord-023865-6rafp3x3 383 33 that that DT cord-023865-6rafp3x3 383 34 promoter promoter NN cord-023865-6rafp3x3 383 35 or or CC cord-023865-6rafp3x3 383 36 whether whether IN cord-023865-6rafp3x3 383 37 it -PRON- PRP cord-023865-6rafp3x3 383 38 is be VBZ cord-023865-6rafp3x3 383 39 a a DT cord-023865-6rafp3x3 383 40 global global JJ cord-023865-6rafp3x3 383 41 phenomenon phenomenon NN cord-023865-6rafp3x3 383 42 . . . cord-023865-6rafp3x3 384 1 In in IN cord-023865-6rafp3x3 384 2 such such PDT cord-023865-6rafp3x3 384 3 a a DT cord-023865-6rafp3x3 384 4 scenario scenario NN cord-023865-6rafp3x3 384 5 , , , cord-023865-6rafp3x3 384 6 there there EX cord-023865-6rafp3x3 384 7 may may MD cord-023865-6rafp3x3 384 8 be be VB cord-023865-6rafp3x3 384 9 complicated complicated JJ cord-023865-6rafp3x3 384 10 cross cross NN cord-023865-6rafp3x3 384 11 - - NN cord-023865-6rafp3x3 384 12 talk talk NN cord-023865-6rafp3x3 384 13 between between IN cord-023865-6rafp3x3 384 14 the the DT cord-023865-6rafp3x3 384 15 ability ability NN cord-023865-6rafp3x3 384 16 of of IN cord-023865-6rafp3x3 384 17 N n NN cord-023865-6rafp3x3 384 18 - - HYPH cord-023865-6rafp3x3 384 19 protein protein NN cord-023865-6rafp3x3 384 20 to to TO cord-023865-6rafp3x3 384 21 deregulate deregulate VB cord-023865-6rafp3x3 384 22 the the DT cord-023865-6rafp3x3 384 23 expression expression NN cord-023865-6rafp3x3 384 24 of of IN cord-023865-6rafp3x3 384 25 COX2 COX2 NNP cord-023865-6rafp3x3 384 26 and and CC cord-023865-6rafp3x3 384 27 IFN IFN NNP cord-023865-6rafp3x3 384 28 in in IN cord-023865-6rafp3x3 384 29 infected infected JJ cord-023865-6rafp3x3 384 30 cells cell NNS cord-023865-6rafp3x3 384 31 . . . cord-023865-6rafp3x3 385 1 Lastly lastly RB cord-023865-6rafp3x3 385 2 , , , cord-023865-6rafp3x3 385 3 the the DT cord-023865-6rafp3x3 385 4 N n NN cord-023865-6rafp3x3 385 5 - - HYPH cord-023865-6rafp3x3 385 6 protein protein NN cord-023865-6rafp3x3 385 7 is be VBZ cord-023865-6rafp3x3 385 8 known know VBN cord-023865-6rafp3x3 385 9 to to TO cord-023865-6rafp3x3 385 10 be be VB cord-023865-6rafp3x3 385 11 the the DT cord-023865-6rafp3x3 385 12 most most RBS cord-023865-6rafp3x3 385 13 abundantly abundantly RB cord-023865-6rafp3x3 385 14 expressed express VBN cord-023865-6rafp3x3 385 15 protein protein NN cord-023865-6rafp3x3 385 16 of of IN cord-023865-6rafp3x3 385 17 the the DT cord-023865-6rafp3x3 385 18 SARS SARS NNP cord-023865-6rafp3x3 386 1 -CoV. -cov. ADD cord-023865-6rafp3x3 387 1 Therefore therefore RB cord-023865-6rafp3x3 387 2 , , , cord-023865-6rafp3x3 387 3 any any DT cord-023865-6rafp3x3 387 4 information information NN cord-023865-6rafp3x3 387 5 generated generate VBN cord-023865-6rafp3x3 387 6 from from IN cord-023865-6rafp3x3 387 7 the the DT cord-023865-6rafp3x3 387 8 analysis analysis NN cord-023865-6rafp3x3 387 9 of of IN cord-023865-6rafp3x3 387 10 this this DT cord-023865-6rafp3x3 387 11 protein protein NN cord-023865-6rafp3x3 387 12 , , , cord-023865-6rafp3x3 387 13 whether whether IN cord-023865-6rafp3x3 387 14 in in IN cord-023865-6rafp3x3 387 15 vivo vivo NNP cord-023865-6rafp3x3 387 16 or or CC cord-023865-6rafp3x3 387 17 ex ex FW cord-023865-6rafp3x3 387 18 vivo vivo NN cord-023865-6rafp3x3 387 19 , , , cord-023865-6rafp3x3 387 20 will will MD cord-023865-6rafp3x3 387 21 definitely definitely RB cord-023865-6rafp3x3 387 22 help help VB cord-023865-6rafp3x3 387 23 to to TO cord-023865-6rafp3x3 387 24 increase increase VB cord-023865-6rafp3x3 387 25 our -PRON- PRP$ cord-023865-6rafp3x3 387 26 understanding understanding NN cord-023865-6rafp3x3 387 27 of of IN cord-023865-6rafp3x3 387 28 the the DT cord-023865-6rafp3x3 387 29 biology biology NN cord-023865-6rafp3x3 387 30 of of IN cord-023865-6rafp3x3 387 31 SARS SARS NNP cord-023865-6rafp3x3 387 32 - - HYPH cord-023865-6rafp3x3 387 33 CoV CoV NNP cord-023865-6rafp3x3 387 34 and and CC cord-023865-6rafp3x3 387 35 may may MD cord-023865-6rafp3x3 387 36 someday someday RB cord-023865-6rafp3x3 387 37 help help VB cord-023865-6rafp3x3 387 38 to to TO cord-023865-6rafp3x3 387 39 design design VB cord-023865-6rafp3x3 387 40 better well JJR cord-023865-6rafp3x3 387 41 protective protective JJ cord-023865-6rafp3x3 387 42 tools tool NNS cord-023865-6rafp3x3 387 43 against against IN cord-023865-6rafp3x3 387 44 it -PRON- PRP cord-023865-6rafp3x3 387 45 . . . cord-023865-6rafp3x3 388 1 Transforming transform VBG cord-023865-6rafp3x3 388 2 growth growth NN cord-023865-6rafp3x3 388 3 factor factor NN cord-023865-6rafp3x3 388 4 beta beta NN cord-023865-6rafp3x3 388 5 in in IN cord-023865-6rafp3x3 388 6 tissue tissue NN cord-023865-6rafp3x3 388 7 fibrosis fibrosis NN cord-023865-6rafp3x3 388 8 Contributions contribution NNS cord-023865-6rafp3x3 388 9 of of IN cord-023865-6rafp3x3 388 10 the the DT cord-023865-6rafp3x3 388 11 structural structural JJ cord-023865-6rafp3x3 388 12 proteins protein NNS cord-023865-6rafp3x3 388 13 of of IN cord-023865-6rafp3x3 388 14 severe severe JJ cord-023865-6rafp3x3 388 15 acute acute JJ cord-023865-6rafp3x3 388 16 respiratory respiratory JJ cord-023865-6rafp3x3 388 17 syndrome syndrome NN cord-023865-6rafp3x3 388 18 coronavirus coronavirus NN cord-023865-6rafp3x3 388 19 to to IN cord-023865-6rafp3x3 388 20 protective protective JJ cord-023865-6rafp3x3 388 21 immunity immunity NN cord-023865-6rafp3x3 388 22 Antigenic antigenic JJ cord-023865-6rafp3x3 388 23 and and CC cord-023865-6rafp3x3 388 24 cellular cellular JJ cord-023865-6rafp3x3 388 25 localisation localisation NN cord-023865-6rafp3x3 388 26 analysis analysis NN cord-023865-6rafp3x3 388 27 of of IN cord-023865-6rafp3x3 388 28 the the DT cord-023865-6rafp3x3 388 29 severe severe JJ cord-023865-6rafp3x3 388 30 acute acute JJ cord-023865-6rafp3x3 388 31 respiratory respiratory JJ cord-023865-6rafp3x3 388 32 syndrome syndrome NN cord-023865-6rafp3x3 388 33 coronavirus coronavirus NN cord-023865-6rafp3x3 388 34 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 388 35 protein protein NN cord-023865-6rafp3x3 388 36 using use VBG cord-023865-6rafp3x3 388 37 monoclonal monoclonal JJ cord-023865-6rafp3x3 388 38 antibodies antibody NNS cord-023865-6rafp3x3 388 39 Modular Modular NNP cord-023865-6rafp3x3 388 40 organization organization NN cord-023865-6rafp3x3 388 41 of of IN cord-023865-6rafp3x3 388 42 SARS SARS NNP cord-023865-6rafp3x3 388 43 coronavirus coronavirus NN cord-023865-6rafp3x3 388 44 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 388 45 protein protein NN cord-023865-6rafp3x3 388 46 Multiple multiple JJ cord-023865-6rafp3x3 388 47 nucleic nucleic JJ cord-023865-6rafp3x3 388 48 acid acid NN cord-023865-6rafp3x3 388 49 binding bind VBG cord-023865-6rafp3x3 388 50 sites site NNS cord-023865-6rafp3x3 388 51 and and CC cord-023865-6rafp3x3 388 52 intrinsic intrinsic JJ cord-023865-6rafp3x3 388 53 disorder disorder NN cord-023865-6rafp3x3 388 54 of of IN cord-023865-6rafp3x3 388 55 SARS SARS NNP cord-023865-6rafp3x3 388 56 coronavirus coronavirus NN cord-023865-6rafp3x3 388 57 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 388 58 protein protein NNP cord-023865-6rafp3x3 388 59 -implication -implication NN cord-023865-6rafp3x3 388 60 for for IN cord-023865-6rafp3x3 388 61 ribonucleocapsid ribonucleocapsid NNP cord-023865-6rafp3x3 388 62 protein protein NNP cord-023865-6rafp3x3 388 63 packaging packaging NN cord-023865-6rafp3x3 388 64 Nucleocapsid Nucleocapsid NNP cord-023865-6rafp3x3 388 65 protein protein NN cord-023865-6rafp3x3 388 66 as as IN cord-023865-6rafp3x3 388 67 early early JJ cord-023865-6rafp3x3 388 68 diagnostic diagnostic JJ cord-023865-6rafp3x3 388 69 marker marker NN cord-023865-6rafp3x3 388 70 for for IN cord-023865-6rafp3x3 388 71 SARS SARS NNP cord-023865-6rafp3x3 388 72 Structure Structure NNP cord-023865-6rafp3x3 388 73 of of IN cord-023865-6rafp3x3 388 74 the the DT cord-023865-6rafp3x3 388 75 SARS SARS NNP cord-023865-6rafp3x3 388 76 Coronavirus Coronavirus NNP cord-023865-6rafp3x3 388 77 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 388 78 protein protein NN cord-023865-6rafp3x3 388 79 RNA RNA NNP cord-023865-6rafp3x3 388 80 - - HYPH cord-023865-6rafp3x3 388 81 binding bind VBG cord-023865-6rafp3x3 388 82 dimerization dimerization NN cord-023865-6rafp3x3 388 83 domain domain NN cord-023865-6rafp3x3 388 84 suggests suggest VBZ cord-023865-6rafp3x3 388 85 a a DT cord-023865-6rafp3x3 388 86 mechanism mechanism NN cord-023865-6rafp3x3 388 87 for for IN cord-023865-6rafp3x3 388 88 helical helical JJ cord-023865-6rafp3x3 388 89 packaging packaging NN cord-023865-6rafp3x3 388 90 of of IN cord-023865-6rafp3x3 388 91 viral viral JJ cord-023865-6rafp3x3 388 92 RNA RNA NNP cord-023865-6rafp3x3 388 93 Translation Translation NNP cord-023865-6rafp3x3 388 94 elongation elongation NN cord-023865-6rafp3x3 388 95 factor factor NN cord-023865-6rafp3x3 388 96 1-alpha 1-alpha CD cord-023865-6rafp3x3 388 97 interacts interact VBZ cord-023865-6rafp3x3 388 98 specifically specifically RB cord-023865-6rafp3x3 388 99 with with IN cord-023865-6rafp3x3 389 1 the the DT cord-023865-6rafp3x3 389 2 HIV-1 HIV-1 NNP cord-023865-6rafp3x3 389 3 Gag Gag NNP cord-023865-6rafp3x3 389 4 polyprotein polyprotein JJ cord-023865-6rafp3x3 389 5 Copious copious JJ cord-023865-6rafp3x3 389 6 production production NN cord-023865-6rafp3x3 389 7 of of IN cord-023865-6rafp3x3 389 8 SARS SARS NNP cord-023865-6rafp3x3 389 9 - - HYPH cord-023865-6rafp3x3 389 10 CoV CoV NNP cord-023865-6rafp3x3 389 11 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 389 12 protein protein NNP cord-023865-6rafp3x3 389 13 employing employ VBG cord-023865-6rafp3x3 389 14 codon codon NN cord-023865-6rafp3x3 389 15 optimized optimize VBN cord-023865-6rafp3x3 389 16 synthetic synthetic JJ cord-023865-6rafp3x3 389 17 gene gene NN cord-023865-6rafp3x3 389 18 Generation generation NN cord-023865-6rafp3x3 389 19 of of IN cord-023865-6rafp3x3 389 20 human human JJ cord-023865-6rafp3x3 389 21 antibody antibody NN cord-023865-6rafp3x3 389 22 fragments fragment NNS cord-023865-6rafp3x3 389 23 recognizing recognize VBG cord-023865-6rafp3x3 389 24 distinct distinct JJ cord-023865-6rafp3x3 389 25 epitopes epitope NNS cord-023865-6rafp3x3 389 26 of of IN cord-023865-6rafp3x3 389 27 the the DT cord-023865-6rafp3x3 389 28 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 389 29 ( ( -LRB- cord-023865-6rafp3x3 389 30 N N NNP cord-023865-6rafp3x3 389 31 ) ) -RRB- cord-023865-6rafp3x3 389 32 SARS SARS NNP cord-023865-6rafp3x3 389 33 - - HYPH cord-023865-6rafp3x3 389 34 CoV CoV NNP cord-023865-6rafp3x3 389 35 protein protein NN cord-023865-6rafp3x3 389 36 using use VBG cord-023865-6rafp3x3 389 37 a a DT cord-023865-6rafp3x3 389 38 phage phage NN cord-023865-6rafp3x3 389 39 display display NN cord-023865-6rafp3x3 389 40 approach approach NN cord-023865-6rafp3x3 389 41 Crystal Crystal NNP cord-023865-6rafp3x3 389 42 structure structure NN cord-023865-6rafp3x3 389 43 of of IN cord-023865-6rafp3x3 389 44 human human JJ cord-023865-6rafp3x3 389 45 cyclophilin cyclophilin NNP cord-023865-6rafp3x3 389 46 A A NNP cord-023865-6rafp3x3 389 47 bound bind VBN cord-023865-6rafp3x3 389 48 to to IN cord-023865-6rafp3x3 389 49 the the DT cord-023865-6rafp3x3 389 50 amino amino NN cord-023865-6rafp3x3 389 51 - - HYPH cord-023865-6rafp3x3 389 52 terminal terminal NN cord-023865-6rafp3x3 389 53 domain domain NN cord-023865-6rafp3x3 389 54 of of IN cord-023865-6rafp3x3 389 55 HIV-1 HIV-1 NNP cord-023865-6rafp3x3 389 56 capsid capsid NN cord-023865-6rafp3x3 389 57 Effects effect NNS cord-023865-6rafp3x3 389 58 of of IN cord-023865-6rafp3x3 389 59 a a DT cord-023865-6rafp3x3 389 60 SARS SARS NNP cord-023865-6rafp3x3 389 61 - - HYPH cord-023865-6rafp3x3 389 62 associated associate VBN cord-023865-6rafp3x3 389 63 coronavirus coronavirus NN cord-023865-6rafp3x3 389 64 vaccine vaccine NN cord-023865-6rafp3x3 389 65 in in IN cord-023865-6rafp3x3 389 66 monkeys monkey NNS cord-023865-6rafp3x3 390 1 The the DT cord-023865-6rafp3x3 390 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 390 3 protein protein NN cord-023865-6rafp3x3 390 4 of of IN cord-023865-6rafp3x3 390 5 SARS SARS NNP cord-023865-6rafp3x3 390 6 - - HYPH cord-023865-6rafp3x3 390 7 CoV CoV NNP cord-023865-6rafp3x3 390 8 induces induce VBZ cord-023865-6rafp3x3 390 9 transcription transcription NN cord-023865-6rafp3x3 390 10 of of IN cord-023865-6rafp3x3 390 11 hfgl2 hfgl2 NNP cord-023865-6rafp3x3 390 12 prothrombinase prothrombinase NNP cord-023865-6rafp3x3 390 13 gene gene NN cord-023865-6rafp3x3 390 14 dependent dependent JJ cord-023865-6rafp3x3 390 15 on on IN cord-023865-6rafp3x3 390 16 C C NNP cord-023865-6rafp3x3 390 17 / / SYM cord-023865-6rafp3x3 390 18 EBP EBP NNP cord-023865-6rafp3x3 390 19 alpha alpha NN cord-023865-6rafp3x3 390 20 Activation activation NN cord-023865-6rafp3x3 390 21 of of IN cord-023865-6rafp3x3 390 22 AP-1 AP-1 NNP cord-023865-6rafp3x3 390 23 signal signal NN cord-023865-6rafp3x3 390 24 transduction transduction NN cord-023865-6rafp3x3 390 25 pathway pathway NN cord-023865-6rafp3x3 390 26 by by IN cord-023865-6rafp3x3 390 27 SARS SARS NNP cord-023865-6rafp3x3 390 28 coronavirus coronavirus NN cord-023865-6rafp3x3 390 29 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 390 30 protein protein NNP cord-023865-6rafp3x3 390 31 Analysis Analysis NNP cord-023865-6rafp3x3 390 32 of of IN cord-023865-6rafp3x3 390 33 multimerization multimerization NN cord-023865-6rafp3x3 390 34 of of IN cord-023865-6rafp3x3 390 35 the the DT cord-023865-6rafp3x3 390 36 SARS SARS NNP cord-023865-6rafp3x3 390 37 coronavirus coronavirus NN cord-023865-6rafp3x3 390 38 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 390 39 protein protein NN cord-023865-6rafp3x3 390 40 Characterization characterization NN cord-023865-6rafp3x3 390 41 of of IN cord-023865-6rafp3x3 390 42 monoclonal monoclonal JJ cord-023865-6rafp3x3 390 43 antibody antibody NN cord-023865-6rafp3x3 390 44 against against IN cord-023865-6rafp3x3 390 45 SARS SARS NNP cord-023865-6rafp3x3 390 46 coronavirus coronavirus NN cord-023865-6rafp3x3 390 47 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 390 48 antigen antigen NNP cord-023865-6rafp3x3 390 49 and and CC cord-023865-6rafp3x3 390 50 development development NN cord-023865-6rafp3x3 390 51 of of IN cord-023865-6rafp3x3 390 52 an an DT cord-023865-6rafp3x3 390 53 antigen antigen NN cord-023865-6rafp3x3 390 54 capture capture NN cord-023865-6rafp3x3 390 55 ELISA ELISA NNP cord-023865-6rafp3x3 390 56 Assembly Assembly NNP cord-023865-6rafp3x3 390 57 of of IN cord-023865-6rafp3x3 390 58 severe severe JJ cord-023865-6rafp3x3 390 59 acute acute JJ cord-023865-6rafp3x3 390 60 respiratory respiratory JJ cord-023865-6rafp3x3 390 61 syndrome syndrome NN cord-023865-6rafp3x3 390 62 coronavirus coronavirus NN cord-023865-6rafp3x3 390 63 RNA RNA NNP cord-023865-6rafp3x3 390 64 packaging packaging NN cord-023865-6rafp3x3 390 65 signal signal NN cord-023865-6rafp3x3 390 66 into into IN cord-023865-6rafp3x3 390 67 virus virus NN cord-023865-6rafp3x3 390 68 - - HYPH cord-023865-6rafp3x3 390 69 like like JJ cord-023865-6rafp3x3 390 70 particles particle NNS cord-023865-6rafp3x3 390 71 is be VBZ cord-023865-6rafp3x3 390 72 nucleocapsid nucleocapsid RB cord-023865-6rafp3x3 390 73 dependent dependent JJ cord-023865-6rafp3x3 390 74 Chronological chronological JJ cord-023865-6rafp3x3 390 75 evolution evolution NN cord-023865-6rafp3x3 390 76 of of IN cord-023865-6rafp3x3 390 77 IgM IgM NNP cord-023865-6rafp3x3 390 78 , , , cord-023865-6rafp3x3 390 79 IgA IgA NNP cord-023865-6rafp3x3 390 80 , , , cord-023865-6rafp3x3 390 81 IgG IgG NNP cord-023865-6rafp3x3 390 82 and and CC cord-023865-6rafp3x3 390 83 neutralisation neutralisation NN cord-023865-6rafp3x3 390 84 antibodies antibody NNS cord-023865-6rafp3x3 390 85 after after IN cord-023865-6rafp3x3 390 86 infection infection NN cord-023865-6rafp3x3 390 87 with with IN cord-023865-6rafp3x3 390 88 SARS SARS NNP cord-023865-6rafp3x3 390 89 - - HYPH cord-023865-6rafp3x3 390 90 associated associate VBN cord-023865-6rafp3x3 390 91 coronavirus coronavirus NN cord-023865-6rafp3x3 390 92 Structure Structure NNP cord-023865-6rafp3x3 390 93 of of IN cord-023865-6rafp3x3 390 94 the the DT cord-023865-6rafp3x3 390 95 N n CD cord-023865-6rafp3x3 390 96 - - HYPH cord-023865-6rafp3x3 390 97 terminal terminal NN cord-023865-6rafp3x3 390 98 RNA RNA NNP cord-023865-6rafp3x3 390 99 - - HYPH cord-023865-6rafp3x3 390 100 binding bind VBG cord-023865-6rafp3x3 390 101 domain domain NN cord-023865-6rafp3x3 390 102 of of IN cord-023865-6rafp3x3 390 103 the the DT cord-023865-6rafp3x3 390 104 SARS SARS NNP cord-023865-6rafp3x3 390 105 CoV CoV NNP cord-023865-6rafp3x3 390 106 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 390 107 protein protein NNP cord-023865-6rafp3x3 390 108 Generation Generation NNP cord-023865-6rafp3x3 390 109 and and CC cord-023865-6rafp3x3 390 110 characterization characterization NN cord-023865-6rafp3x3 390 111 of of IN cord-023865-6rafp3x3 390 112 DNA dna NN cord-023865-6rafp3x3 390 113 vaccines vaccine NNS cord-023865-6rafp3x3 390 114 targeting target VBG cord-023865-6rafp3x3 390 115 the the DT cord-023865-6rafp3x3 390 116 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 390 117 protein protein NN cord-023865-6rafp3x3 390 118 of of IN cord-023865-6rafp3x3 390 119 severe severe JJ cord-023865-6rafp3x3 390 120 acute acute JJ cord-023865-6rafp3x3 390 121 respiratory respiratory JJ cord-023865-6rafp3x3 390 122 syndrome syndrome NN cord-023865-6rafp3x3 390 123 coronavirus coronavirus NN cord-023865-6rafp3x3 390 124 Severe severe JJ cord-023865-6rafp3x3 390 125 acute acute JJ cord-023865-6rafp3x3 390 126 respiratory respiratory JJ cord-023865-6rafp3x3 390 127 syndrome syndrome NN cord-023865-6rafp3x3 390 128 coronavirus coronavirus NN cord-023865-6rafp3x3 390 129 open open JJ cord-023865-6rafp3x3 390 130 reading reading NN cord-023865-6rafp3x3 390 131 frame frame NN cord-023865-6rafp3x3 390 132 ( ( -LRB- cord-023865-6rafp3x3 390 133 ORF ORF NNP cord-023865-6rafp3x3 390 134 ) ) -RRB- cord-023865-6rafp3x3 390 135 3b 3b NNP cord-023865-6rafp3x3 390 136 , , , cord-023865-6rafp3x3 390 137 ORF ORF NNP cord-023865-6rafp3x3 390 138 6 6 CD cord-023865-6rafp3x3 390 139 , , , cord-023865-6rafp3x3 390 140 and and CC cord-023865-6rafp3x3 390 141 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 390 142 proteins protein NNS cord-023865-6rafp3x3 390 143 function function VBP cord-023865-6rafp3x3 390 144 as as IN cord-023865-6rafp3x3 390 145 interferon interferon NN cord-023865-6rafp3x3 390 146 antagonists antagonist NNS cord-023865-6rafp3x3 390 147 Mass Mass NNP cord-023865-6rafp3x3 390 148 spectrometric spectrometric JJ cord-023865-6rafp3x3 390 149 characterization characterization NN cord-023865-6rafp3x3 390 150 of of IN cord-023865-6rafp3x3 390 151 proteins protein NNS cord-023865-6rafp3x3 390 152 from from IN cord-023865-6rafp3x3 390 153 the the DT cord-023865-6rafp3x3 390 154 SARS SARS NNP cord-023865-6rafp3x3 390 155 Virus Virus NNP cord-023865-6rafp3x3 390 156 : : : cord-023865-6rafp3x3 390 157 a a DT cord-023865-6rafp3x3 390 158 preliminary preliminary JJ cord-023865-6rafp3x3 390 159 report report NN cord-023865-6rafp3x3 390 160 Characterization characterization NN cord-023865-6rafp3x3 390 161 of of IN cord-023865-6rafp3x3 390 162 F F NNP cord-023865-6rafp3x3 390 163 - - HYPH cord-023865-6rafp3x3 390 164 actin actin JJ cord-023865-6rafp3x3 390 165 bundling bundling NN cord-023865-6rafp3x3 390 166 activity activity NN cord-023865-6rafp3x3 390 167 of of IN cord-023865-6rafp3x3 390 168 Tetrahymena Tetrahymena NNP cord-023865-6rafp3x3 390 169 elongation elongation NN cord-023865-6rafp3x3 390 170 factor factor NN cord-023865-6rafp3x3 390 171 1 1 CD cord-023865-6rafp3x3 390 172 alpha alpha NN cord-023865-6rafp3x3 390 173 investigated investigate VBN cord-023865-6rafp3x3 390 174 with with IN cord-023865-6rafp3x3 390 175 rabbit rabbit NN cord-023865-6rafp3x3 390 176 skeletal skeletal JJ cord-023865-6rafp3x3 390 177 muscle muscle NN cord-023865-6rafp3x3 390 178 actin actin NN cord-023865-6rafp3x3 390 179 Extremely extremely RB cord-023865-6rafp3x3 390 180 low low JJ cord-023865-6rafp3x3 390 181 exposure exposure NN cord-023865-6rafp3x3 390 182 of of IN cord-023865-6rafp3x3 390 183 a a DT cord-023865-6rafp3x3 390 184 community community NN cord-023865-6rafp3x3 390 185 to to TO cord-023865-6rafp3x3 390 186 severe severe JJ cord-023865-6rafp3x3 390 187 acute acute JJ cord-023865-6rafp3x3 390 188 respiratory respiratory JJ cord-023865-6rafp3x3 390 189 syndrome syndrome NN cord-023865-6rafp3x3 390 190 coronavirus coronavirus NN cord-023865-6rafp3x3 390 191 : : : cord-023865-6rafp3x3 390 192 false false JJ cord-023865-6rafp3x3 390 193 seropositivity seropositivity NN cord-023865-6rafp3x3 390 194 due due IN cord-023865-6rafp3x3 390 195 to to IN cord-023865-6rafp3x3 390 196 use use NN cord-023865-6rafp3x3 390 197 of of IN cord-023865-6rafp3x3 390 198 bacterially bacterially RB cord-023865-6rafp3x3 390 199 derived derive VBN cord-023865-6rafp3x3 390 200 antigens antigen NNS cord-023865-6rafp3x3 390 201 Sumoylation Sumoylation NNP cord-023865-6rafp3x3 390 202 of of IN cord-023865-6rafp3x3 390 203 the the DT cord-023865-6rafp3x3 390 204 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 390 205 protein protein NN cord-023865-6rafp3x3 390 206 of of IN cord-023865-6rafp3x3 390 207 severe severe JJ cord-023865-6rafp3x3 390 208 acute acute JJ cord-023865-6rafp3x3 390 209 respiratory respiratory JJ cord-023865-6rafp3x3 390 210 syndrome syndrome NN cord-023865-6rafp3x3 390 211 coronavirus coronavirus NN cord-023865-6rafp3x3 390 212 Detection detection NN cord-023865-6rafp3x3 390 213 of of IN cord-023865-6rafp3x3 390 214 the the DT cord-023865-6rafp3x3 390 215 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 390 216 protein protein NN cord-023865-6rafp3x3 390 217 of of IN cord-023865-6rafp3x3 390 218 severe severe JJ cord-023865-6rafp3x3 390 219 acute acute JJ cord-023865-6rafp3x3 390 220 respiratory respiratory JJ cord-023865-6rafp3x3 390 221 syndrome syndrome NN cord-023865-6rafp3x3 390 222 coronavirus coronavirus NN cord-023865-6rafp3x3 390 223 in in IN cord-023865-6rafp3x3 390 224 serum serum NN cord-023865-6rafp3x3 390 225 : : : cord-023865-6rafp3x3 390 226 comparison comparison NN cord-023865-6rafp3x3 390 227 with with IN cord-023865-6rafp3x3 390 228 results result NNS cord-023865-6rafp3x3 390 229 of of IN cord-023865-6rafp3x3 390 230 other other JJ cord-023865-6rafp3x3 390 231 viral viral JJ cord-023865-6rafp3x3 390 232 markers marker NNS cord-023865-6rafp3x3 390 233 SARS SARS NNP cord-023865-6rafp3x3 390 234 patients patient NNS cord-023865-6rafp3x3 390 235 - - HYPH cord-023865-6rafp3x3 390 236 derived derive VBN cord-023865-6rafp3x3 390 237 human human JJ cord-023865-6rafp3x3 390 238 recombinant recombinant JJ cord-023865-6rafp3x3 390 239 antibodies antibody NNS cord-023865-6rafp3x3 390 240 to to IN cord-023865-6rafp3x3 390 241 S S NNP cord-023865-6rafp3x3 390 242 and and CC cord-023865-6rafp3x3 390 243 M M NNP cord-023865-6rafp3x3 390 244 proteins protein NNS cord-023865-6rafp3x3 390 245 efficiently efficiently RB cord-023865-6rafp3x3 390 246 neutralize neutralize VBP cord-023865-6rafp3x3 390 247 SARS SARS NNP cord-023865-6rafp3x3 390 248 - - HYPH cord-023865-6rafp3x3 390 249 coronavirus coronavirus NN cord-023865-6rafp3x3 390 250 infectivity infectivity NN cord-023865-6rafp3x3 390 251 Activation activation NN cord-023865-6rafp3x3 390 252 of of IN cord-023865-6rafp3x3 390 253 NF NF NNP cord-023865-6rafp3x3 390 254 - - HYPH cord-023865-6rafp3x3 390 255 kappaB kappaB NNP cord-023865-6rafp3x3 390 256 by by IN cord-023865-6rafp3x3 390 257 the the DT cord-023865-6rafp3x3 390 258 full full JJ cord-023865-6rafp3x3 390 259 - - HYPH cord-023865-6rafp3x3 390 260 length length NN cord-023865-6rafp3x3 390 261 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 390 262 protein protein NN cord-023865-6rafp3x3 390 263 of of IN cord-023865-6rafp3x3 390 264 the the DT cord-023865-6rafp3x3 390 265 SARS SARS NNP cord-023865-6rafp3x3 390 266 coronavirus coronavirus NN cord-023865-6rafp3x3 391 1 The the DT cord-023865-6rafp3x3 391 2 C C NNP cord-023865-6rafp3x3 391 3 - - HYPH cord-023865-6rafp3x3 391 4 terminal terminal NN cord-023865-6rafp3x3 391 5 portion portion NN cord-023865-6rafp3x3 391 6 of of IN cord-023865-6rafp3x3 391 7 the the DT cord-023865-6rafp3x3 391 8 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 391 9 protein protein NN cord-023865-6rafp3x3 391 10 demonstrates demonstrate VBZ cord-023865-6rafp3x3 391 11 SARS SARS NNP cord-023865-6rafp3x3 391 12 - - HYPH cord-023865-6rafp3x3 391 13 CoV CoV NNP cord-023865-6rafp3x3 391 14 antigenicity antigenicity NNP cord-023865-6rafp3x3 391 15 High high JJ cord-023865-6rafp3x3 391 16 - - HYPH cord-023865-6rafp3x3 391 17 yield yield NN cord-023865-6rafp3x3 391 18 expression expression NN cord-023865-6rafp3x3 391 19 of of IN cord-023865-6rafp3x3 391 20 recombinant recombinant JJ cord-023865-6rafp3x3 391 21 SARS SARS NNP cord-023865-6rafp3x3 391 22 coronavirus coronavirus NN cord-023865-6rafp3x3 391 23 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 391 24 protein protein NN cord-023865-6rafp3x3 391 25 in in IN cord-023865-6rafp3x3 391 26 methylotrophic methylotrophic JJ cord-023865-6rafp3x3 391 27 yeast yeast NN cord-023865-6rafp3x3 391 28 Pichia Pichia NNP cord-023865-6rafp3x3 391 29 pastoris pastoris NN cord-023865-6rafp3x3 391 30 Immunofluorescence immunofluorescence NN cord-023865-6rafp3x3 391 31 assay assay NN cord-023865-6rafp3x3 391 32 for for IN cord-023865-6rafp3x3 391 33 detection detection NN cord-023865-6rafp3x3 391 34 of of IN cord-023865-6rafp3x3 391 35 the the DT cord-023865-6rafp3x3 391 36 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 391 37 antigen antigen NN cord-023865-6rafp3x3 391 38 of of IN cord-023865-6rafp3x3 391 39 the the DT cord-023865-6rafp3x3 391 40 severe severe JJ cord-023865-6rafp3x3 391 41 acute acute JJ cord-023865-6rafp3x3 391 42 respiratory respiratory JJ cord-023865-6rafp3x3 391 43 syndrome syndrome NN cord-023865-6rafp3x3 391 44 ( ( -LRB- cord-023865-6rafp3x3 391 45 SARS)-associated sars)-associated CD cord-023865-6rafp3x3 391 46 coronavirus coronavirus NN cord-023865-6rafp3x3 391 47 in in IN cord-023865-6rafp3x3 391 48 cells cell NNS cord-023865-6rafp3x3 391 49 derived derive VBN cord-023865-6rafp3x3 391 50 from from IN cord-023865-6rafp3x3 391 51 throat throat NN cord-023865-6rafp3x3 391 52 wash wash NN cord-023865-6rafp3x3 391 53 samples sample NNS cord-023865-6rafp3x3 391 54 of of IN cord-023865-6rafp3x3 391 55 patients patient NNS cord-023865-6rafp3x3 391 56 with with IN cord-023865-6rafp3x3 391 57 SARS SARS NNP cord-023865-6rafp3x3 391 58 Immunological immunological JJ cord-023865-6rafp3x3 391 59 characterizations characterization NNS cord-023865-6rafp3x3 391 60 of of IN cord-023865-6rafp3x3 391 61 the the DT cord-023865-6rafp3x3 391 62 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 391 63 protein protein NNP cord-023865-6rafp3x3 392 1 based base VBN cord-023865-6rafp3x3 392 2 SARS SARS NNP cord-023865-6rafp3x3 392 3 vaccine vaccine NN cord-023865-6rafp3x3 392 4 candidates candidate NNS cord-023865-6rafp3x3 393 1 Nucleocapsid nucleocapsid JJ cord-023865-6rafp3x3 393 2 protein protein NN cord-023865-6rafp3x3 393 3 of of IN cord-023865-6rafp3x3 393 4 SARS SARS NNP cord-023865-6rafp3x3 393 5 coronavirus coronavirus NN cord-023865-6rafp3x3 393 6 tightly tightly RB cord-023865-6rafp3x3 393 7 binds bind VBZ cord-023865-6rafp3x3 393 8 to to IN cord-023865-6rafp3x3 393 9 human human JJ cord-023865-6rafp3x3 393 10 cyclophilin cyclophilin NN cord-023865-6rafp3x3 394 1 A a DT cord-023865-6rafp3x3 395 1 In in IN cord-023865-6rafp3x3 395 2 vitro vitro FW cord-023865-6rafp3x3 395 3 biochemical biochemical JJ cord-023865-6rafp3x3 395 4 and and CC cord-023865-6rafp3x3 395 5 thermodynamic thermodynamic JJ cord-023865-6rafp3x3 395 6 characterization characterization NN cord-023865-6rafp3x3 395 7 of of IN cord-023865-6rafp3x3 395 8 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 395 9 protein protein NN cord-023865-6rafp3x3 395 10 of of IN cord-023865-6rafp3x3 395 11 SARS SARS NNP cord-023865-6rafp3x3 396 1 The the DT cord-023865-6rafp3x3 396 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 396 3 protein protein NN cord-023865-6rafp3x3 396 4 of of IN cord-023865-6rafp3x3 396 5 SARS SARS NNP cord-023865-6rafp3x3 396 6 coronavirus coronavirus NN cord-023865-6rafp3x3 396 7 has have VBZ cord-023865-6rafp3x3 396 8 a a DT cord-023865-6rafp3x3 396 9 high high JJ cord-023865-6rafp3x3 396 10 binding bind VBG cord-023865-6rafp3x3 396 11 affinity affinity NN cord-023865-6rafp3x3 396 12 to to IN cord-023865-6rafp3x3 396 13 the the DT cord-023865-6rafp3x3 396 14 human human JJ cord-023865-6rafp3x3 396 15 cellular cellular JJ cord-023865-6rafp3x3 396 16 heterogeneous heterogeneous JJ cord-023865-6rafp3x3 396 17 nuclear nuclear JJ cord-023865-6rafp3x3 396 18 ribonucleoprotein ribonucleoprotein NN cord-023865-6rafp3x3 396 19 A1 A1 NNP cord-023865-6rafp3x3 396 20 Carboxyl Carboxyl NNP cord-023865-6rafp3x3 396 21 terminus terminus NN cord-023865-6rafp3x3 396 22 of of IN cord-023865-6rafp3x3 396 23 severe severe JJ cord-023865-6rafp3x3 396 24 acute acute JJ cord-023865-6rafp3x3 396 25 respiratory respiratory JJ cord-023865-6rafp3x3 396 26 syndrome syndrome NN cord-023865-6rafp3x3 396 27 coronavirus coronavirus NN cord-023865-6rafp3x3 396 28 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 396 29 protein protein NN cord-023865-6rafp3x3 396 30 : : : cord-023865-6rafp3x3 396 31 self self NN cord-023865-6rafp3x3 396 32 - - HYPH cord-023865-6rafp3x3 396 33 association association NN cord-023865-6rafp3x3 396 34 analysis analysis NN cord-023865-6rafp3x3 396 35 and and CC cord-023865-6rafp3x3 396 36 nucleic nucleic JJ cord-023865-6rafp3x3 396 37 acid acid NN cord-023865-6rafp3x3 396 38 binding bind VBG cord-023865-6rafp3x3 396 39 characterization characterization NN cord-023865-6rafp3x3 396 40 Lung Lung NNP cord-023865-6rafp3x3 396 41 pathology pathology NN cord-023865-6rafp3x3 396 42 of of IN cord-023865-6rafp3x3 396 43 fatal fatal JJ cord-023865-6rafp3x3 396 44 severe severe JJ cord-023865-6rafp3x3 396 45 acute acute JJ cord-023865-6rafp3x3 396 46 respiratory respiratory JJ cord-023865-6rafp3x3 396 47 syndrome syndrome NN cord-023865-6rafp3x3 397 1 Nucleophosmin Nucleophosmin NNP cord-023865-6rafp3x3 397 2 / / SYM cord-023865-6rafp3x3 397 3 B23 B23 NNP cord-023865-6rafp3x3 397 4 is be VBZ cord-023865-6rafp3x3 397 5 a a DT cord-023865-6rafp3x3 397 6 target target NN cord-023865-6rafp3x3 397 7 of of IN cord-023865-6rafp3x3 397 8 CDK2 CDK2 NNP cord-023865-6rafp3x3 397 9 / / SYM cord-023865-6rafp3x3 397 10 cyclin cyclin NN cord-023865-6rafp3x3 397 11 E e NN cord-023865-6rafp3x3 397 12 in in IN cord-023865-6rafp3x3 397 13 centrosome centrosome NN cord-023865-6rafp3x3 397 14 duplication duplication NN cord-023865-6rafp3x3 397 15 Protective protective JJ cord-023865-6rafp3x3 397 16 humoral humoral JJ cord-023865-6rafp3x3 397 17 responses response NNS cord-023865-6rafp3x3 397 18 to to IN cord-023865-6rafp3x3 397 19 severe severe JJ cord-023865-6rafp3x3 397 20 acute acute JJ cord-023865-6rafp3x3 397 21 respiratory respiratory JJ cord-023865-6rafp3x3 397 22 syndrome syndrome NN cord-023865-6rafp3x3 397 23 - - HYPH cord-023865-6rafp3x3 397 24 associated associate VBN cord-023865-6rafp3x3 397 25 coronavirus coronavirus NN cord-023865-6rafp3x3 397 26 : : : cord-023865-6rafp3x3 398 1 implications implication NNS cord-023865-6rafp3x3 398 2 for for IN cord-023865-6rafp3x3 398 3 the the DT cord-023865-6rafp3x3 398 4 design design NN cord-023865-6rafp3x3 398 5 of of IN cord-023865-6rafp3x3 398 6 an an DT cord-023865-6rafp3x3 398 7 effective effective JJ cord-023865-6rafp3x3 398 8 protein protein NN cord-023865-6rafp3x3 398 9 - - HYPH cord-023865-6rafp3x3 398 10 based base VBN cord-023865-6rafp3x3 398 11 vaccine vaccine NN cord-023865-6rafp3x3 398 12 Expression expression NN cord-023865-6rafp3x3 398 13 of of IN cord-023865-6rafp3x3 398 14 SARS SARS NNP cord-023865-6rafp3x3 398 15 - - HYPH cord-023865-6rafp3x3 398 16 coronavirus coronavirus NN cord-023865-6rafp3x3 398 17 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 398 18 protein protein NN cord-023865-6rafp3x3 398 19 in in IN cord-023865-6rafp3x3 398 20 Escherichia Escherichia NNP cord-023865-6rafp3x3 398 21 coli coli NNS cord-023865-6rafp3x3 398 22 and and CC cord-023865-6rafp3x3 398 23 Lactococcus Lactococcus NNP cord-023865-6rafp3x3 398 24 lactis lactis NNP cord-023865-6rafp3x3 398 25 for for IN cord-023865-6rafp3x3 398 26 serodiagnosis serodiagnosis NNP cord-023865-6rafp3x3 398 27 and and CC cord-023865-6rafp3x3 398 28 mucosal mucosal JJ cord-023865-6rafp3x3 398 29 vaccination vaccination NN cord-023865-6rafp3x3 398 30 Use Use NNP cord-023865-6rafp3x3 398 31 of of IN cord-023865-6rafp3x3 398 32 the the DT cord-023865-6rafp3x3 398 33 COOH COOH NNP cord-023865-6rafp3x3 398 34 portion portion NN cord-023865-6rafp3x3 398 35 of of IN cord-023865-6rafp3x3 398 36 the the DT cord-023865-6rafp3x3 398 37 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 398 38 protein protein NN cord-023865-6rafp3x3 398 39 in in IN cord-023865-6rafp3x3 398 40 an an DT cord-023865-6rafp3x3 398 41 antigen antigen NN cord-023865-6rafp3x3 398 42 - - HYPH cord-023865-6rafp3x3 398 43 capturing capture VBG cord-023865-6rafp3x3 398 44 enzymelinked enzymelinked JJ cord-023865-6rafp3x3 398 45 immunosorbent immunosorbent JJ cord-023865-6rafp3x3 398 46 assay assay NN cord-023865-6rafp3x3 398 47 for for IN cord-023865-6rafp3x3 398 48 specific specific JJ cord-023865-6rafp3x3 398 49 and and CC cord-023865-6rafp3x3 398 50 sensitive sensitive JJ cord-023865-6rafp3x3 398 51 detection detection NN cord-023865-6rafp3x3 398 52 of of IN cord-023865-6rafp3x3 398 53 severe severe JJ cord-023865-6rafp3x3 398 54 acute acute JJ cord-023865-6rafp3x3 398 55 respiratory respiratory JJ cord-023865-6rafp3x3 398 56 syndrome syndrome NN cord-023865-6rafp3x3 398 57 coronavirus coronavirus NN cord-023865-6rafp3x3 398 58 Smad3 Smad3 NNP cord-023865-6rafp3x3 398 59 is be VBZ cord-023865-6rafp3x3 398 60 key key JJ cord-023865-6rafp3x3 398 61 to to IN cord-023865-6rafp3x3 398 62 TGF TGF NNP cord-023865-6rafp3x3 398 63 - - HYPH cord-023865-6rafp3x3 398 64 beta beta NN cord-023865-6rafp3x3 398 65 - - HYPH cord-023865-6rafp3x3 398 66 mediated mediate VBN cord-023865-6rafp3x3 398 67 epithelial epithelial NN cord-023865-6rafp3x3 398 68 - - HYPH cord-023865-6rafp3x3 398 69 to to IN cord-023865-6rafp3x3 398 70 - - HYPH cord-023865-6rafp3x3 398 71 mesenchymal mesenchymal JJ cord-023865-6rafp3x3 398 72 transition transition NN cord-023865-6rafp3x3 398 73 , , , cord-023865-6rafp3x3 398 74 fibrosis fibrosis NN cord-023865-6rafp3x3 398 75 , , , cord-023865-6rafp3x3 398 76 tumor tumor NN cord-023865-6rafp3x3 398 77 suppression suppression NN cord-023865-6rafp3x3 398 78 and and CC cord-023865-6rafp3x3 398 79 metastasis metastasis NN cord-023865-6rafp3x3 398 80 Characterization characterization NN cord-023865-6rafp3x3 398 81 of of IN cord-023865-6rafp3x3 398 82 a a DT cord-023865-6rafp3x3 398 83 novel novel JJ cord-023865-6rafp3x3 398 84 coronavirus coronavirus NN cord-023865-6rafp3x3 398 85 associated associate VBN cord-023865-6rafp3x3 398 86 with with IN cord-023865-6rafp3x3 398 87 severe severe JJ cord-023865-6rafp3x3 398 88 acute acute JJ cord-023865-6rafp3x3 398 89 respiratory respiratory JJ cord-023865-6rafp3x3 398 90 syndrome syndrome NN cord-023865-6rafp3x3 398 91 Intracellular Intracellular NNP cord-023865-6rafp3x3 398 92 localization localization NN cord-023865-6rafp3x3 398 93 of of IN cord-023865-6rafp3x3 398 94 the the DT cord-023865-6rafp3x3 398 95 severe severe JJ cord-023865-6rafp3x3 398 96 acute acute JJ cord-023865-6rafp3x3 398 97 respiratory respiratory JJ cord-023865-6rafp3x3 398 98 syndrome syndrome NN cord-023865-6rafp3x3 398 99 coronavirus coronavirus NN cord-023865-6rafp3x3 398 100 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 398 101 protein protein NN cord-023865-6rafp3x3 398 102 : : : cord-023865-6rafp3x3 398 103 absence absence NN cord-023865-6rafp3x3 398 104 of of IN cord-023865-6rafp3x3 398 105 nucleolar nucleolar JJ cord-023865-6rafp3x3 398 106 accumulation accumulation NN cord-023865-6rafp3x3 398 107 during during IN cord-023865-6rafp3x3 398 108 infection infection NN cord-023865-6rafp3x3 398 109 and and CC cord-023865-6rafp3x3 398 110 after after IN cord-023865-6rafp3x3 398 111 expression expression NN cord-023865-6rafp3x3 398 112 as as IN cord-023865-6rafp3x3 398 113 a a DT cord-023865-6rafp3x3 398 114 recombinant recombinant JJ cord-023865-6rafp3x3 398 115 protein protein NN cord-023865-6rafp3x3 398 116 in in IN cord-023865-6rafp3x3 398 117 vero vero NNP cord-023865-6rafp3x3 398 118 cells cell NNS cord-023865-6rafp3x3 398 119 Recombinant Recombinant NNP cord-023865-6rafp3x3 398 120 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 398 121 protein protein NN cord-023865-6rafp3x3 398 122 - - HYPH cord-023865-6rafp3x3 398 123 based base VBN cord-023865-6rafp3x3 398 124 IgG igg NN cord-023865-6rafp3x3 398 125 enzyme enzyme NN cord-023865-6rafp3x3 398 126 - - HYPH cord-023865-6rafp3x3 398 127 linked link VBN cord-023865-6rafp3x3 398 128 immunosorbent immunosorbent JJ cord-023865-6rafp3x3 398 129 assay assay NN cord-023865-6rafp3x3 398 130 for for IN cord-023865-6rafp3x3 398 131 the the DT cord-023865-6rafp3x3 398 132 serological serological JJ cord-023865-6rafp3x3 398 133 diagnosis diagnosis NN cord-023865-6rafp3x3 398 134 of of IN cord-023865-6rafp3x3 398 135 SARS SARS NNP cord-023865-6rafp3x3 398 136 Characterization Characterization NNP cord-023865-6rafp3x3 398 137 and and CC cord-023865-6rafp3x3 398 138 application application NN cord-023865-6rafp3x3 398 139 of of IN cord-023865-6rafp3x3 398 140 monoclonal monoclonal JJ cord-023865-6rafp3x3 398 141 antibodies antibody NNS cord-023865-6rafp3x3 398 142 against against IN cord-023865-6rafp3x3 398 143 N n CD cord-023865-6rafp3x3 398 144 protein protein NN cord-023865-6rafp3x3 398 145 of of IN cord-023865-6rafp3x3 398 146 SARScoronavirus SARScoronavirus NNP cord-023865-6rafp3x3 398 147 Antigenic Antigenic NNP cord-023865-6rafp3x3 398 148 characterization characterization NN cord-023865-6rafp3x3 398 149 of of IN cord-023865-6rafp3x3 398 150 severe severe JJ cord-023865-6rafp3x3 398 151 acute acute JJ cord-023865-6rafp3x3 398 152 respiratory respiratory JJ cord-023865-6rafp3x3 398 153 syndrome syndrome NN cord-023865-6rafp3x3 398 154 - - HYPH cord-023865-6rafp3x3 398 155 coronavirus coronavirus NN cord-023865-6rafp3x3 398 156 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 398 157 protein protein NN cord-023865-6rafp3x3 398 158 expressed express VBN cord-023865-6rafp3x3 398 159 in in IN cord-023865-6rafp3x3 398 160 insect insect NN cord-023865-6rafp3x3 398 161 cells cell NNS cord-023865-6rafp3x3 398 162 : : : cord-023865-6rafp3x3 399 1 The the DT cord-023865-6rafp3x3 399 2 effect effect NN cord-023865-6rafp3x3 399 3 of of IN cord-023865-6rafp3x3 399 4 phosphorlation phosphorlation NN cord-023865-6rafp3x3 399 5 on on IN cord-023865-6rafp3x3 399 6 immunoreactivity immunoreactivity NN cord-023865-6rafp3x3 399 7 and and CC cord-023865-6rafp3x3 399 8 specificity specificity NN cord-023865-6rafp3x3 399 9 Inhibition inhibition NN cord-023865-6rafp3x3 399 10 of of IN cord-023865-6rafp3x3 399 11 beta beta JJ cord-023865-6rafp3x3 399 12 interferon interferon NN cord-023865-6rafp3x3 399 13 induction induction NN cord-023865-6rafp3x3 399 14 by by IN cord-023865-6rafp3x3 399 15 severe severe JJ cord-023865-6rafp3x3 399 16 acute acute JJ cord-023865-6rafp3x3 399 17 respiratory respiratory JJ cord-023865-6rafp3x3 399 18 syndrome syndrome NN cord-023865-6rafp3x3 399 19 coronavirus coronavirus NN cord-023865-6rafp3x3 399 20 suggests suggest VBZ cord-023865-6rafp3x3 399 21 a a DT cord-023865-6rafp3x3 399 22 two two CD cord-023865-6rafp3x3 399 23 - - HYPH cord-023865-6rafp3x3 399 24 step step NN cord-023865-6rafp3x3 399 25 model model NN cord-023865-6rafp3x3 399 26 for for IN cord-023865-6rafp3x3 399 27 activation activation NN cord-023865-6rafp3x3 399 28 of of IN cord-023865-6rafp3x3 399 29 interferon interferon NN cord-023865-6rafp3x3 399 30 regulatory regulatory JJ cord-023865-6rafp3x3 399 31 factor factor NN cord-023865-6rafp3x3 399 32 3 3 CD cord-023865-6rafp3x3 399 33 Antigenic Antigenic NNP cord-023865-6rafp3x3 399 34 cross cross NN cord-023865-6rafp3x3 399 35 - - NN cord-023865-6rafp3x3 399 36 reactivity reactivity NN cord-023865-6rafp3x3 399 37 between between IN cord-023865-6rafp3x3 399 38 the the DT cord-023865-6rafp3x3 399 39 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 399 40 protein protein NN cord-023865-6rafp3x3 399 41 of of IN cord-023865-6rafp3x3 399 42 severe severe JJ cord-023865-6rafp3x3 399 43 acute acute JJ cord-023865-6rafp3x3 399 44 respiratory respiratory JJ cord-023865-6rafp3x3 399 45 syndrome syndrome NN cord-023865-6rafp3x3 399 46 ( ( -LRB- cord-023865-6rafp3x3 399 47 SARS SARS NNP cord-023865-6rafp3x3 399 48 ) ) -RRB- cord-023865-6rafp3x3 399 49 coronavirus coronavirus NN cord-023865-6rafp3x3 399 50 and and CC cord-023865-6rafp3x3 399 51 polyclonal polyclonal JJ cord-023865-6rafp3x3 399 52 antisera antisera NN cord-023865-6rafp3x3 399 53 of of IN cord-023865-6rafp3x3 399 54 antigenic antigenic JJ cord-023865-6rafp3x3 399 55 group group NN cord-023865-6rafp3x3 399 56 I -PRON- PRP cord-023865-6rafp3x3 399 57 animal animal NN cord-023865-6rafp3x3 399 58 coronaviruses coronaviruse NNS cord-023865-6rafp3x3 399 59 : : : cord-023865-6rafp3x3 399 60 implication implication NN cord-023865-6rafp3x3 399 61 for for IN cord-023865-6rafp3x3 399 62 SARS SARS NNP cord-023865-6rafp3x3 399 63 diagnosis diagnosis NN cord-023865-6rafp3x3 400 1 The the DT cord-023865-6rafp3x3 400 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 400 3 protein protein NN cord-023865-6rafp3x3 400 4 of of IN cord-023865-6rafp3x3 400 5 the the DT cord-023865-6rafp3x3 400 6 SARS SARS NNP cord-023865-6rafp3x3 400 7 coronavirus coronavirus NN cord-023865-6rafp3x3 400 8 is be VBZ cord-023865-6rafp3x3 400 9 capable capable JJ cord-023865-6rafp3x3 400 10 of of IN cord-023865-6rafp3x3 400 11 self self NN cord-023865-6rafp3x3 400 12 - - HYPH cord-023865-6rafp3x3 400 13 association association NN cord-023865-6rafp3x3 400 14 through through IN cord-023865-6rafp3x3 400 15 a a DT cord-023865-6rafp3x3 400 16 C C NNP cord-023865-6rafp3x3 400 17 - - HYPH cord-023865-6rafp3x3 400 18 terminal terminal NN cord-023865-6rafp3x3 400 19 209 209 CD cord-023865-6rafp3x3 400 20 amino amino NN cord-023865-6rafp3x3 400 21 acid acid NN cord-023865-6rafp3x3 400 22 interaction interaction NN cord-023865-6rafp3x3 400 23 domain domain NN cord-023865-6rafp3x3 401 1 The the DT cord-023865-6rafp3x3 401 2 SARS SARS NNP cord-023865-6rafp3x3 401 3 coronavirus coronavirus NN cord-023865-6rafp3x3 401 4 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 401 5 protein protein NN cord-023865-6rafp3x3 401 6 induces induce VBZ cord-023865-6rafp3x3 401 7 actin actin NN cord-023865-6rafp3x3 401 8 reorganization reorganization NN cord-023865-6rafp3x3 401 9 and and CC cord-023865-6rafp3x3 401 10 apoptosis apoptosis NN cord-023865-6rafp3x3 401 11 in in IN cord-023865-6rafp3x3 401 12 COS-1 COS-1 NNP cord-023865-6rafp3x3 401 13 cells cell NNS cord-023865-6rafp3x3 401 14 in in IN cord-023865-6rafp3x3 401 15 the the DT cord-023865-6rafp3x3 401 16 absence absence NN cord-023865-6rafp3x3 401 17 of of IN cord-023865-6rafp3x3 401 18 growth growth NN cord-023865-6rafp3x3 401 19 factors factor NNS cord-023865-6rafp3x3 402 1 The the DT cord-023865-6rafp3x3 402 2 severe severe JJ cord-023865-6rafp3x3 402 3 acute acute JJ cord-023865-6rafp3x3 402 4 respiratory respiratory JJ cord-023865-6rafp3x3 402 5 syndrome syndrome NN cord-023865-6rafp3x3 402 6 coronavirus coronavirus NN cord-023865-6rafp3x3 402 7 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 402 8 protein protein NN cord-023865-6rafp3x3 402 9 is be VBZ cord-023865-6rafp3x3 402 10 phosphorylated phosphorylate VBN cord-023865-6rafp3x3 402 11 and and CC cord-023865-6rafp3x3 402 12 localizes localize VBZ cord-023865-6rafp3x3 402 13 in in IN cord-023865-6rafp3x3 402 14 the the DT cord-023865-6rafp3x3 402 15 cytoplasm cytoplasm NN cord-023865-6rafp3x3 402 16 by by IN cord-023865-6rafp3x3 402 17 14 14 CD cord-023865-6rafp3x3 402 18 - - SYM cord-023865-6rafp3x3 402 19 3 3 CD cord-023865-6rafp3x3 402 20 - - HYPH cord-023865-6rafp3x3 402 21 3-mediated 3-mediated CD cord-023865-6rafp3x3 402 22 translocation translocation NN cord-023865-6rafp3x3 403 1 The the DT cord-023865-6rafp3x3 403 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 3 protein protein NN cord-023865-6rafp3x3 403 4 of of IN cord-023865-6rafp3x3 403 5 severe severe JJ cord-023865-6rafp3x3 403 6 acute acute JJ cord-023865-6rafp3x3 403 7 respiratory respiratory JJ cord-023865-6rafp3x3 403 8 syndrome syndrome NN cord-023865-6rafp3x3 403 9 - - HYPH cord-023865-6rafp3x3 403 10 coronavirus coronavirus NN cord-023865-6rafp3x3 403 11 inhibits inhibit VBZ cord-023865-6rafp3x3 403 12 the the DT cord-023865-6rafp3x3 403 13 activity activity NN cord-023865-6rafp3x3 403 14 of of IN cord-023865-6rafp3x3 403 15 cyclin cyclin JJ cord-023865-6rafp3x3 403 16 - - HYPH cord-023865-6rafp3x3 403 17 cyclin cyclin NN cord-023865-6rafp3x3 403 18 - - HYPH cord-023865-6rafp3x3 403 19 dependent dependent JJ cord-023865-6rafp3x3 403 20 kinase kinase NN cord-023865-6rafp3x3 403 21 complex complex NN cord-023865-6rafp3x3 403 22 and and CC cord-023865-6rafp3x3 403 23 blocks block VBZ cord-023865-6rafp3x3 403 24 S s NN cord-023865-6rafp3x3 403 25 phase phase NN cord-023865-6rafp3x3 403 26 progression progression NN cord-023865-6rafp3x3 403 27 in in IN cord-023865-6rafp3x3 403 28 mammalian mammalian JJ cord-023865-6rafp3x3 403 29 cells cell NNS cord-023865-6rafp3x3 403 30 Nuclear nuclear JJ cord-023865-6rafp3x3 403 31 / / SYM cord-023865-6rafp3x3 403 32 nucleolar nucleolar JJ cord-023865-6rafp3x3 403 33 localization localization NN cord-023865-6rafp3x3 403 34 properties property NNS cord-023865-6rafp3x3 403 35 of of IN cord-023865-6rafp3x3 403 36 C C NNP cord-023865-6rafp3x3 403 37 - - HYPH cord-023865-6rafp3x3 403 38 terminal terminal NNP cord-023865-6rafp3x3 403 39 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 403 40 protein protein NN cord-023865-6rafp3x3 403 41 of of IN cord-023865-6rafp3x3 403 42 SARS SARS NNP cord-023865-6rafp3x3 403 43 coronavirus coronavirus NN cord-023865-6rafp3x3 403 44 Specific specific JJ cord-023865-6rafp3x3 403 45 phosphorylation phosphorylation NN cord-023865-6rafp3x3 403 46 of of IN cord-023865-6rafp3x3 403 47 nucleophosmin nucleophosmin NNS cord-023865-6rafp3x3 403 48 on on IN cord-023865-6rafp3x3 403 49 Thr(199 Thr(199 NNP cord-023865-6rafp3x3 403 50 ) ) -RRB- cord-023865-6rafp3x3 403 51 by by IN cord-023865-6rafp3x3 403 52 cyclin cyclin NN cord-023865-6rafp3x3 403 53 - - HYPH cord-023865-6rafp3x3 403 54 dependent dependent JJ cord-023865-6rafp3x3 403 55 kinase kinase NN cord-023865-6rafp3x3 403 56 2-cyclin 2-cyclin CD cord-023865-6rafp3x3 403 57 E E NNS cord-023865-6rafp3x3 403 58 and and CC cord-023865-6rafp3x3 403 59 its -PRON- PRP$ cord-023865-6rafp3x3 403 60 role role NN cord-023865-6rafp3x3 403 61 in in IN cord-023865-6rafp3x3 403 62 centrosome centrosome NN cord-023865-6rafp3x3 403 63 duplication duplication NN cord-023865-6rafp3x3 403 64 Direct direct JJ cord-023865-6rafp3x3 403 65 sequencing sequencing NN cord-023865-6rafp3x3 403 66 of of IN cord-023865-6rafp3x3 403 67 SARScoronavirus SARScoronavirus NNP cord-023865-6rafp3x3 403 68 S S NNP cord-023865-6rafp3x3 403 69 and and CC cord-023865-6rafp3x3 403 70 N n CD cord-023865-6rafp3x3 403 71 genes gene NNS cord-023865-6rafp3x3 403 72 from from IN cord-023865-6rafp3x3 403 73 clinical clinical JJ cord-023865-6rafp3x3 403 74 specimens specimen NNS cord-023865-6rafp3x3 403 75 shows show VBZ cord-023865-6rafp3x3 403 76 limited limited JJ cord-023865-6rafp3x3 403 77 variation variation NN cord-023865-6rafp3x3 403 78 Low low JJ cord-023865-6rafp3x3 403 79 stability stability NN cord-023865-6rafp3x3 403 80 of of IN cord-023865-6rafp3x3 403 81 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 82 protein protein NN cord-023865-6rafp3x3 403 83 in in IN cord-023865-6rafp3x3 403 84 SARS SARS NNP cord-023865-6rafp3x3 403 85 virus virus NN cord-023865-6rafp3x3 403 86 Immune immune JJ cord-023865-6rafp3x3 403 87 responses response NNS cord-023865-6rafp3x3 403 88 with with IN cord-023865-6rafp3x3 403 89 DNA dna NN cord-023865-6rafp3x3 403 90 vaccines vaccine NNS cord-023865-6rafp3x3 403 91 encoded encode VBD cord-023865-6rafp3x3 403 92 different different JJ cord-023865-6rafp3x3 403 93 gene gene NN cord-023865-6rafp3x3 403 94 fragments fragment NNS cord-023865-6rafp3x3 403 95 of of IN cord-023865-6rafp3x3 403 96 severe severe JJ cord-023865-6rafp3x3 403 97 acute acute JJ cord-023865-6rafp3x3 403 98 respiratory respiratory JJ cord-023865-6rafp3x3 403 99 syndrome syndrome NN cord-023865-6rafp3x3 403 100 coronavirus coronavirus NN cord-023865-6rafp3x3 403 101 in in IN cord-023865-6rafp3x3 403 102 BALB BALB NNP cord-023865-6rafp3x3 403 103 / / SYM cord-023865-6rafp3x3 403 104 c c NN cord-023865-6rafp3x3 403 105 mice mouse NNS cord-023865-6rafp3x3 403 106 Longitudinal longitudinal JJ cord-023865-6rafp3x3 403 107 profile profile NN cord-023865-6rafp3x3 403 108 of of IN cord-023865-6rafp3x3 403 109 immunoglobulin immunoglobulin NN cord-023865-6rafp3x3 403 110 G G NNP cord-023865-6rafp3x3 403 111 ( ( -LRB- cord-023865-6rafp3x3 403 112 IgG IgG NNP cord-023865-6rafp3x3 403 113 ) ) -RRB- cord-023865-6rafp3x3 403 114 , , , cord-023865-6rafp3x3 403 115 IgM IgM NNP cord-023865-6rafp3x3 403 116 , , , cord-023865-6rafp3x3 403 117 and and CC cord-023865-6rafp3x3 403 118 IgA IgA NNP cord-023865-6rafp3x3 403 119 antibodies antibody NNS cord-023865-6rafp3x3 403 120 against against IN cord-023865-6rafp3x3 403 121 the the DT cord-023865-6rafp3x3 403 122 severe severe JJ cord-023865-6rafp3x3 403 123 acute acute JJ cord-023865-6rafp3x3 403 124 respiratory respiratory JJ cord-023865-6rafp3x3 403 125 syndrome syndrome NN cord-023865-6rafp3x3 403 126 ( ( -LRB- cord-023865-6rafp3x3 403 127 SARS SARS NNP cord-023865-6rafp3x3 403 128 ) ) -RRB- cord-023865-6rafp3x3 403 129 coronavirus coronavirus NN cord-023865-6rafp3x3 403 130 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 131 protein protein NN cord-023865-6rafp3x3 403 132 in in IN cord-023865-6rafp3x3 403 133 patients patient NNS cord-023865-6rafp3x3 403 134 with with IN cord-023865-6rafp3x3 403 135 pneumonia pneumonia NN cord-023865-6rafp3x3 403 136 due due IN cord-023865-6rafp3x3 403 137 to to IN cord-023865-6rafp3x3 403 138 the the DT cord-023865-6rafp3x3 403 139 SARS SARS NNP cord-023865-6rafp3x3 403 140 coronavirus coronavirus NN cord-023865-6rafp3x3 403 141 Differential differential JJ cord-023865-6rafp3x3 403 142 sensitivities sensitivity NNS cord-023865-6rafp3x3 403 143 of of IN cord-023865-6rafp3x3 403 144 severe severe JJ cord-023865-6rafp3x3 403 145 acute acute JJ cord-023865-6rafp3x3 403 146 respiratory respiratory JJ cord-023865-6rafp3x3 403 147 syndrome syndrome NN cord-023865-6rafp3x3 403 148 ( ( -LRB- cord-023865-6rafp3x3 403 149 SARS SARS NNP cord-023865-6rafp3x3 403 150 ) ) -RRB- cord-023865-6rafp3x3 403 151 coronavirus coronavirus NN cord-023865-6rafp3x3 403 152 spike spike NN cord-023865-6rafp3x3 403 153 polypeptide polypeptide NN cord-023865-6rafp3x3 403 154 enzyme enzyme NN cord-023865-6rafp3x3 403 155 - - HYPH cord-023865-6rafp3x3 403 156 linked link VBN cord-023865-6rafp3x3 403 157 immunosorbent immunosorbent JJ cord-023865-6rafp3x3 403 158 assay assay NN cord-023865-6rafp3x3 403 159 ( ( -LRB- cord-023865-6rafp3x3 403 160 ELISA ELISA NNP cord-023865-6rafp3x3 403 161 ) ) -RRB- cord-023865-6rafp3x3 403 162 and and CC cord-023865-6rafp3x3 403 163 SARS SARS NNP cord-023865-6rafp3x3 403 164 coronavirus coronavirus NN cord-023865-6rafp3x3 403 165 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 166 protein protein NN cord-023865-6rafp3x3 403 167 ELISA ELISA NNP cord-023865-6rafp3x3 403 168 for for IN cord-023865-6rafp3x3 403 169 serodiagnosis serodiagnosis NNP cord-023865-6rafp3x3 403 170 of of IN cord-023865-6rafp3x3 403 171 SARS SARS NNP cord-023865-6rafp3x3 403 172 coronavirus coronavirus NN cord-023865-6rafp3x3 403 173 pneumonia pneumonia NN cord-023865-6rafp3x3 403 174 Glycogen Glycogen NNP cord-023865-6rafp3x3 403 175 synthase synthase NN cord-023865-6rafp3x3 403 176 kinase-3 kinase-3 NNP cord-023865-6rafp3x3 403 177 regulates regulate VBZ cord-023865-6rafp3x3 403 178 the the DT cord-023865-6rafp3x3 403 179 phosphorylation phosphorylation NN cord-023865-6rafp3x3 403 180 of of IN cord-023865-6rafp3x3 403 181 sars sars NNP cord-023865-6rafp3x3 403 182 - - HYPH cord-023865-6rafp3x3 403 183 coronavirus coronavirus NNP cord-023865-6rafp3x3 403 184 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 185 protein protein NN cord-023865-6rafp3x3 403 186 and and CC cord-023865-6rafp3x3 403 187 viral viral JJ cord-023865-6rafp3x3 403 188 replication replication NN cord-023865-6rafp3x3 403 189 Nucleocapsid Nucleocapsid NNP cord-023865-6rafp3x3 403 190 protein protein NN cord-023865-6rafp3x3 403 191 of of IN cord-023865-6rafp3x3 403 192 SARS SARS NNP cord-023865-6rafp3x3 403 193 - - HYPH cord-023865-6rafp3x3 403 194 CoV CoV NNP cord-023865-6rafp3x3 403 195 activates activate VBZ cord-023865-6rafp3x3 403 196 the the DT cord-023865-6rafp3x3 403 197 expression expression NN cord-023865-6rafp3x3 403 198 of of IN cord-023865-6rafp3x3 403 199 cyclooxygenase-2 cyclooxygenase-2 NNP cord-023865-6rafp3x3 403 200 by by IN cord-023865-6rafp3x3 403 201 binding bind VBG cord-023865-6rafp3x3 403 202 directly directly RB cord-023865-6rafp3x3 403 203 to to IN cord-023865-6rafp3x3 403 204 regulatory regulatory JJ cord-023865-6rafp3x3 403 205 elements element NNS cord-023865-6rafp3x3 403 206 for for IN cord-023865-6rafp3x3 403 207 nuclear nuclear JJ cord-023865-6rafp3x3 403 208 factor factor NN cord-023865-6rafp3x3 403 209 - - HYPH cord-023865-6rafp3x3 403 210 kappa kappa NN cord-023865-6rafp3x3 403 211 B B NNP cord-023865-6rafp3x3 403 212 and and CC cord-023865-6rafp3x3 403 213 CCAAT CCAAT NNP cord-023865-6rafp3x3 403 214 / / SYM cord-023865-6rafp3x3 403 215 enhancer enhancer NN cord-023865-6rafp3x3 403 216 binding bind VBG cord-023865-6rafp3x3 403 217 protein protein NN cord-023865-6rafp3x3 403 218 Identification identification NN cord-023865-6rafp3x3 403 219 of of IN cord-023865-6rafp3x3 403 220 an an DT cord-023865-6rafp3x3 403 221 actinbinding actinbinde VBG cord-023865-6rafp3x3 403 222 protein protein NN cord-023865-6rafp3x3 403 223 from from IN cord-023865-6rafp3x3 403 224 Dictyostelium Dictyostelium NNP cord-023865-6rafp3x3 403 225 as as IN cord-023865-6rafp3x3 403 226 elongation elongation NN cord-023865-6rafp3x3 403 227 factor factor NN cord-023865-6rafp3x3 403 228 1a 1a NN cord-023865-6rafp3x3 403 229 Naturally naturally RB cord-023865-6rafp3x3 403 230 occurring occur VBG cord-023865-6rafp3x3 403 231 anti anti JJ cord-023865-6rafp3x3 403 232 - - JJ cord-023865-6rafp3x3 403 233 Escherichia escherichia JJ cord-023865-6rafp3x3 403 234 coli coli NNS cord-023865-6rafp3x3 403 235 protein protein NN cord-023865-6rafp3x3 403 236 antibodies antibody NNS cord-023865-6rafp3x3 403 237 in in IN cord-023865-6rafp3x3 403 238 the the DT cord-023865-6rafp3x3 403 239 sera sera NNP cord-023865-6rafp3x3 403 240 of of IN cord-023865-6rafp3x3 403 241 healthy healthy JJ cord-023865-6rafp3x3 403 242 humans human NNS cord-023865-6rafp3x3 403 243 cause cause VBP cord-023865-6rafp3x3 403 244 analytical analytical JJ cord-023865-6rafp3x3 403 245 interference interference NN cord-023865-6rafp3x3 403 246 in in IN cord-023865-6rafp3x3 403 247 a a DT cord-023865-6rafp3x3 403 248 recombinant recombinant JJ cord-023865-6rafp3x3 403 249 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 250 protein protein NN cord-023865-6rafp3x3 403 251 - - HYPH cord-023865-6rafp3x3 403 252 based base VBN cord-023865-6rafp3x3 403 253 enzyme enzyme NN cord-023865-6rafp3x3 403 254 - - HYPH cord-023865-6rafp3x3 403 255 linked link VBN cord-023865-6rafp3x3 403 256 immunosorbent immunosorbent JJ cord-023865-6rafp3x3 403 257 assay assay NN cord-023865-6rafp3x3 403 258 for for IN cord-023865-6rafp3x3 403 259 serodiagnosis serodiagnosis NNP cord-023865-6rafp3x3 403 260 of of IN cord-023865-6rafp3x3 403 261 severe severe JJ cord-023865-6rafp3x3 403 262 acute acute JJ cord-023865-6rafp3x3 403 263 respiratory respiratory JJ cord-023865-6rafp3x3 403 264 syndrome syndrome NN cord-023865-6rafp3x3 403 265 Subcellular Subcellular NNP cord-023865-6rafp3x3 403 266 localization localization NN cord-023865-6rafp3x3 403 267 of of IN cord-023865-6rafp3x3 403 268 the the DT cord-023865-6rafp3x3 403 269 severe severe JJ cord-023865-6rafp3x3 403 270 acute acute JJ cord-023865-6rafp3x3 403 271 respiratory respiratory JJ cord-023865-6rafp3x3 403 272 syndrome syndrome NN cord-023865-6rafp3x3 403 273 coronavirus coronavirus NN cord-023865-6rafp3x3 403 274 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 403 275 protein protein NN cord-023865-6rafp3x3 403 276 Recombinant recombinant JJ cord-023865-6rafp3x3 403 277 severe severe JJ cord-023865-6rafp3x3 403 278 acute acute JJ cord-023865-6rafp3x3 403 279 respiratory respiratory JJ cord-023865-6rafp3x3 403 280 syndrome syndrome NN cord-023865-6rafp3x3 403 281 ( ( -LRB- cord-023865-6rafp3x3 403 282 SARS SARS NNP cord-023865-6rafp3x3 403 283 ) ) -RRB- cord-023865-6rafp3x3 404 1 coronavirus coronavirus NNP cord-023865-6rafp3x3 404 2 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 404 3 protein protein NNP cord-023865-6rafp3x3 404 4 forms form VBZ cord-023865-6rafp3x3 404 5 a a DT cord-023865-6rafp3x3 404 6 dimer dimer NN cord-023865-6rafp3x3 404 7 through through IN cord-023865-6rafp3x3 404 8 its -PRON- PRP$ cord-023865-6rafp3x3 404 9 C c NN cord-023865-6rafp3x3 404 10 - - HYPH cord-023865-6rafp3x3 404 11 terminal terminal NN cord-023865-6rafp3x3 404 12 domain domain NN cord-023865-6rafp3x3 404 13 Crystal Crystal NNP cord-023865-6rafp3x3 404 14 structure structure NN cord-023865-6rafp3x3 404 15 of of IN cord-023865-6rafp3x3 405 1 the the DT cord-023865-6rafp3x3 405 2 severe severe JJ cord-023865-6rafp3x3 405 3 acute acute JJ cord-023865-6rafp3x3 405 4 respiratory respiratory JJ cord-023865-6rafp3x3 405 5 syndrome syndrome NN cord-023865-6rafp3x3 405 6 ( ( -LRB- cord-023865-6rafp3x3 405 7 SARS SARS NNP cord-023865-6rafp3x3 405 8 ) ) -RRB- cord-023865-6rafp3x3 405 9 coronavirus coronavirus NN cord-023865-6rafp3x3 405 10 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 405 11 protein protein NN cord-023865-6rafp3x3 405 12 dimerization dimerization NN cord-023865-6rafp3x3 405 13 domain domain NN cord-023865-6rafp3x3 405 14 reveals reveal VBZ cord-023865-6rafp3x3 405 15 evolutionary evolutionary JJ cord-023865-6rafp3x3 405 16 linkage linkage NN cord-023865-6rafp3x3 405 17 between between IN cord-023865-6rafp3x3 405 18 corona corona NN cord-023865-6rafp3x3 405 19 - - HYPH cord-023865-6rafp3x3 405 20 and and CC cord-023865-6rafp3x3 405 21 arteriviridae arteriviridae NN cord-023865-6rafp3x3 405 22 Recombinant Recombinant NNP cord-023865-6rafp3x3 405 23 truncated truncate VBN cord-023865-6rafp3x3 405 24 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 405 25 protein protein NN cord-023865-6rafp3x3 405 26 as as IN cord-023865-6rafp3x3 405 27 antigen antigen NN cord-023865-6rafp3x3 405 28 in in IN cord-023865-6rafp3x3 405 29 a a DT cord-023865-6rafp3x3 405 30 novel novel JJ cord-023865-6rafp3x3 405 31 immunoglobulin immunoglobulin NN cord-023865-6rafp3x3 405 32 M m CD cord-023865-6rafp3x3 405 33 capture capture NN cord-023865-6rafp3x3 405 34 enzymelinked enzymelinked JJ cord-023865-6rafp3x3 405 35 immunosorbent immunosorbent JJ cord-023865-6rafp3x3 405 36 assay assay NN cord-023865-6rafp3x3 405 37 for for IN cord-023865-6rafp3x3 405 38 diagnosis diagnosis NN cord-023865-6rafp3x3 405 39 of of IN cord-023865-6rafp3x3 405 40 severe severe JJ cord-023865-6rafp3x3 405 41 acute acute JJ cord-023865-6rafp3x3 405 42 respiratory respiratory JJ cord-023865-6rafp3x3 405 43 syndrome syndrome NN cord-023865-6rafp3x3 405 44 coronavirus coronavirus NN cord-023865-6rafp3x3 405 45 infection infection NN cord-023865-6rafp3x3 405 46 Severe severe JJ cord-023865-6rafp3x3 405 47 acute acute JJ cord-023865-6rafp3x3 405 48 respiratory respiratory JJ cord-023865-6rafp3x3 405 49 syndrome syndrome NN cord-023865-6rafp3x3 405 50 coronavirus coronavirus NN cord-023865-6rafp3x3 405 51 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 405 52 protein protein NN cord-023865-6rafp3x3 405 53 expressed express VBN cord-023865-6rafp3x3 405 54 by by IN cord-023865-6rafp3x3 405 55 an an DT cord-023865-6rafp3x3 405 56 adenovirus adenovirus NN cord-023865-6rafp3x3 405 57 vector vector NN cord-023865-6rafp3x3 405 58 is be VBZ cord-023865-6rafp3x3 405 59 phosphorylated phosphorylated JJ cord-023865-6rafp3x3 405 60 and and CC cord-023865-6rafp3x3 405 61 immunogenic immunogenic JJ cord-023865-6rafp3x3 405 62 in in IN cord-023865-6rafp3x3 405 63 mice mouse NNS cord-023865-6rafp3x3 406 1 The the DT cord-023865-6rafp3x3 406 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 406 3 protein protein NN cord-023865-6rafp3x3 406 4 of of IN cord-023865-6rafp3x3 406 5 SARS SARS NNP cord-023865-6rafp3x3 406 6 - - HYPH cord-023865-6rafp3x3 406 7 associated associate VBN cord-023865-6rafp3x3 406 8 coronavirus coronavirus NN cord-023865-6rafp3x3 406 9 inhibits inhibit VBZ cord-023865-6rafp3x3 406 10 B23 B23 NNP cord-023865-6rafp3x3 406 11 phosphorylation phosphorylation NN cord-023865-6rafp3x3 406 12 SARS SARS NNP cord-023865-6rafp3x3 406 13 - - HYPH cord-023865-6rafp3x3 406 14 CoV CoV NNP cord-023865-6rafp3x3 406 15 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 406 16 protein protein NNP cord-023865-6rafp3x3 406 17 induced induce VBD cord-023865-6rafp3x3 406 18 apoptosis apoptosis NN cord-023865-6rafp3x3 406 19 of of IN cord-023865-6rafp3x3 406 20 COS-1 COS-1 NNP cord-023865-6rafp3x3 406 21 mediated mediate VBN cord-023865-6rafp3x3 406 22 by by IN cord-023865-6rafp3x3 406 23 the the DT cord-023865-6rafp3x3 406 24 mitochondrial mitochondrial JJ cord-023865-6rafp3x3 406 25 pathway pathway NN cord-023865-6rafp3x3 406 26 Immune Immune NNP cord-023865-6rafp3x3 406 27 responses response NNS cord-023865-6rafp3x3 406 28 against against IN cord-023865-6rafp3x3 406 29 SARS SARS NNP cord-023865-6rafp3x3 406 30 - - HYPH cord-023865-6rafp3x3 406 31 coronavirus coronavirus NN cord-023865-6rafp3x3 406 32 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 406 33 protein protein NN cord-023865-6rafp3x3 406 34 induced induce VBN cord-023865-6rafp3x3 406 35 by by IN cord-023865-6rafp3x3 406 36 DNA dna NN cord-023865-6rafp3x3 406 37 vaccine vaccine NN cord-023865-6rafp3x3 406 38 Identification identification NN cord-023865-6rafp3x3 406 39 and and CC cord-023865-6rafp3x3 406 40 characterization characterization NN cord-023865-6rafp3x3 406 41 of of IN cord-023865-6rafp3x3 406 42 dominant dominant JJ cord-023865-6rafp3x3 406 43 helper helper NN cord-023865-6rafp3x3 406 44 T t NN cord-023865-6rafp3x3 406 45 - - HYPH cord-023865-6rafp3x3 406 46 cell cell NN cord-023865-6rafp3x3 406 47 epitopes epitope NNS cord-023865-6rafp3x3 406 48 in in IN cord-023865-6rafp3x3 406 49 the the DT cord-023865-6rafp3x3 406 50 nucleocapsid nucleocapsid NNP cord-023865-6rafp3x3 406 51 protein protein NN cord-023865-6rafp3x3 406 52 of of IN cord-023865-6rafp3x3 406 53 severe severe JJ cord-023865-6rafp3x3 406 54 acute acute JJ cord-023865-6rafp3x3 406 55 respiratory respiratory JJ cord-023865-6rafp3x3 406 56 syndrome syndrome NN cord-023865-6rafp3x3 406 57 coronavirus coronavirus NN cord-023865-6rafp3x3 406 58 Severe severe JJ cord-023865-6rafp3x3 406 59 acute acute JJ cord-023865-6rafp3x3 406 60 respiratory respiratory JJ cord-023865-6rafp3x3 406 61 syndrome syndrome NN cord-023865-6rafp3x3 406 62 - - HYPH cord-023865-6rafp3x3 406 63 associated associate VBN cord-023865-6rafp3x3 406 64 coronavirus coronavirus NN cord-023865-6rafp3x3 406 65 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 406 66 protein protein NN cord-023865-6rafp3x3 406 67 interacts interact VBZ cord-023865-6rafp3x3 406 68 with with IN cord-023865-6rafp3x3 406 69 Smad3 Smad3 NNP cord-023865-6rafp3x3 406 70 and and CC cord-023865-6rafp3x3 406 71 modulates modulate VBZ cord-023865-6rafp3x3 406 72 transforming transform VBG cord-023865-6rafp3x3 406 73 growth growth NN cord-023865-6rafp3x3 406 74 factor factor NN cord-023865-6rafp3x3 407 1 -beta -beta VBG cord-023865-6rafp3x3 407 2 signaling signal VBG cord-023865-6rafp3x3 407 3 Potent potent JJ cord-023865-6rafp3x3 407 4 inhibition inhibition NN cord-023865-6rafp3x3 407 5 of of IN cord-023865-6rafp3x3 407 6 SARS SARS NNP cord-023865-6rafp3x3 407 7 - - HYPH cord-023865-6rafp3x3 407 8 associated associate VBN cord-023865-6rafp3x3 407 9 coronavirus coronavirus NN cord-023865-6rafp3x3 407 10 ( ( -LRB- cord-023865-6rafp3x3 407 11 SCOV SCOV NNP cord-023865-6rafp3x3 407 12 ) ) -RRB- cord-023865-6rafp3x3 407 13 infection infection NN cord-023865-6rafp3x3 407 14 and and CC cord-023865-6rafp3x3 407 15 replication replication NN cord-023865-6rafp3x3 407 16 by by IN cord-023865-6rafp3x3 407 17 type type NN cord-023865-6rafp3x3 407 18 I -PRON- PRP cord-023865-6rafp3x3 407 19 interferons interferon NNS cord-023865-6rafp3x3 407 20 ( ( -LRB- cord-023865-6rafp3x3 407 21 IFNalpha/ ifnalpha/ NN cord-023865-6rafp3x3 407 22 beta beta NN cord-023865-6rafp3x3 407 23 ) ) -RRB- cord-023865-6rafp3x3 407 24 but but CC cord-023865-6rafp3x3 407 25 not not RB cord-023865-6rafp3x3 407 26 by by IN cord-023865-6rafp3x3 407 27 type type NN cord-023865-6rafp3x3 407 28 II II NNP cord-023865-6rafp3x3 407 29 interferon interferon NN cord-023865-6rafp3x3 408 1 ( ( -LRB- cord-023865-6rafp3x3 408 2 IFN IFN NNP cord-023865-6rafp3x3 408 3 - - HYPH cord-023865-6rafp3x3 408 4 gamma gamma NNP cord-023865-6rafp3x3 408 5 ) ) -RRB- cord-023865-6rafp3x3 409 1 The the DT cord-023865-6rafp3x3 409 2 nucleocapsid nucleocapsid NN cord-023865-6rafp3x3 409 3 protein protein NN cord-023865-6rafp3x3 409 4 of of IN cord-023865-6rafp3x3 409 5 severe severe JJ cord-023865-6rafp3x3 409 6 acute acute JJ cord-023865-6rafp3x3 409 7 respiratory respiratory JJ cord-023865-6rafp3x3 409 8 syndrome syndrome NN cord-023865-6rafp3x3 409 9 coronavirus coronavirus NN cord-023865-6rafp3x3 409 10 inhibits inhibit VBZ cord-023865-6rafp3x3 409 11 cell cell NN cord-023865-6rafp3x3 409 12 cytokinesis cytokinesis NN cord-023865-6rafp3x3 409 13 and and CC cord-023865-6rafp3x3 409 14 proliferation proliferation NN cord-023865-6rafp3x3 409 15 by by IN cord-023865-6rafp3x3 409 16 interacting interact VBG cord-023865-6rafp3x3 409 17 with with IN cord-023865-6rafp3x3 409 18 translation translation NN cord-023865-6rafp3x3 409 19 elongation elongation NN cord-023865-6rafp3x3 409 20 factor factor NN cord-023865-6rafp3x3 409 21 1alpha 1alpha CD cord-023865-6rafp3x3 409 22 Induction Induction NNP cord-023865-6rafp3x3 409 23 of of IN cord-023865-6rafp3x3 409 24 SARSnucleoprotein SARSnucleoprotein NNP cord-023865-6rafp3x3 409 25 - - HYPH cord-023865-6rafp3x3 409 26 specific specific JJ cord-023865-6rafp3x3 409 27 immune immune JJ cord-023865-6rafp3x3 409 28 response response NN cord-023865-6rafp3x3 409 29 by by IN cord-023865-6rafp3x3 409 30 use use NN cord-023865-6rafp3x3 409 31 of of IN cord-023865-6rafp3x3 409 32 DNA dna NN cord-023865-6rafp3x3 409 33 vaccine vaccine NN cord-023865-6rafp3x3 409 34 Acknowledgments acknowledgment NNS cord-023865-6rafp3x3 409 35 The the DT cord-023865-6rafp3x3 409 36 authors author NNS cord-023865-6rafp3x3 409 37 wish wish VBP cord-023865-6rafp3x3 409 38 to to TO cord-023865-6rafp3x3 409 39 thank thank VB cord-023865-6rafp3x3 409 40 Ms. Ms. NNP cord-023865-6rafp3x3 409 41 Alisha Alisha NNP cord-023865-6rafp3x3 409 42 Lal Lal NNP cord-023865-6rafp3x3 409 43 for for IN cord-023865-6rafp3x3 409 44 helping help VBG cord-023865-6rafp3x3 409 45 out out RP cord-023865-6rafp3x3 409 46 in in IN cord-023865-6rafp3x3 409 47 typing type VBG cord-023865-6rafp3x3 409 48 and and CC cord-023865-6rafp3x3 409 49 formatting format VBG cord-023865-6rafp3x3 409 50 this this DT cord-023865-6rafp3x3 409 51 review review NN cord-023865-6rafp3x3 409 52 . . . cord-023865-6rafp3x3 410 1 We -PRON- PRP cord-023865-6rafp3x3 410 2 apologize apologize VBP cord-023865-6rafp3x3 410 3 to to IN cord-023865-6rafp3x3 410 4 all all PDT cord-023865-6rafp3x3 410 5 those those DT cord-023865-6rafp3x3 410 6 colleagues colleague NNS cord-023865-6rafp3x3 410 7 whose whose WP$ cord-023865-6rafp3x3 410 8 work work NN cord-023865-6rafp3x3 410 9 we -PRON- PRP cord-023865-6rafp3x3 410 10 might may MD cord-023865-6rafp3x3 410 11 have have VB cord-023865-6rafp3x3 410 12 omitted omit VBN cord-023865-6rafp3x3 410 13 to to TO cord-023865-6rafp3x3 410 14 cite cite VB cord-023865-6rafp3x3 410 15 in in IN cord-023865-6rafp3x3 410 16 this this DT cord-023865-6rafp3x3 410 17 article article NN cord-023865-6rafp3x3 410 18 . . .