id	sid	tid	token	lemma	pos
cord-010604-3d37o05y	1	1	key	key	JJ
cord-010604-3d37o05y	1	2	:	:	:
cord-010604-3d37o05y	1	3	cord-010604	cord-010604	NNP
cord-010604-3d37o05y	1	4	-	-	HYPH
cord-010604-3d37o05y	1	5	3d37o05y	3d37o05y	CD
cord-010604-3d37o05y	1	6	authors	author	NNS
cord-010604-3d37o05y	1	7	:	:	:
cord-010604-3d37o05y	1	8	Rein	rein	VB
cord-010604-3d37o05y	1	9	,	,	,
cord-010604-3d37o05y	1	10	Theo	Theo	NNP
cord-010604-3d37o05y	1	11	title	title	NN
cord-010604-3d37o05y	1	12	:	:	:
cord-010604-3d37o05y	1	13	Post	post	JJ
cord-010604-3d37o05y	1	14	-	-	JJ
cord-010604-3d37o05y	1	15	translational	translational	JJ
cord-010604-3d37o05y	1	16	modifications	modification	NNS
cord-010604-3d37o05y	1	17	and	and	CC
cord-010604-3d37o05y	1	18	stress	stress	NN
cord-010604-3d37o05y	1	19	adaptation	adaptation	NN
cord-010604-3d37o05y	1	20	:	:	:
cord-010604-3d37o05y	1	21	the	the	DT
cord-010604-3d37o05y	1	22	paradigm	paradigm	NN
cord-010604-3d37o05y	1	23	of	of	IN
cord-010604-3d37o05y	1	24	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	1	25	date	date	NN
cord-010604-3d37o05y	1	26	:	:	:
cord-010604-3d37o05y	1	27	2020	2020	CD
cord-010604-3d37o05y	1	28	-	-	HYPH
cord-010604-3d37o05y	1	29	04	04	CD
cord-010604-3d37o05y	1	30	-	-	HYPH
cord-010604-3d37o05y	1	31	29	29	CD
cord-010604-3d37o05y	1	32	journal	journal	NN
cord-010604-3d37o05y	1	33	:	:	:
cord-010604-3d37o05y	2	1	Biochem	Biochem	NNP
cord-010604-3d37o05y	2	2	Soc	Soc	NNP
cord-010604-3d37o05y	2	3	Trans	Trans	NNP
cord-010604-3d37o05y	2	4	DOI	DOI	NNP
cord-010604-3d37o05y	3	1	:	:	:
cord-010604-3d37o05y	3	2	10.1042	10.1042	CD
cord-010604-3d37o05y	3	3	/	/	SYM
cord-010604-3d37o05y	3	4	bst20190332	bst20190332	NN
cord-010604-3d37o05y	3	5	sha	sha	NNP
cord-010604-3d37o05y	3	6	:	:	:
cord-010604-3d37o05y	4	1	1bff1181a5558af7ffe9f6a60df9c26f95a7a840	1bff1181a5558af7ffe9f6a60df9c26f95a7a840	CD
cord-010604-3d37o05y	4	2	doc_id	doc_id	CD
cord-010604-3d37o05y	4	3	:	:	:
cord-010604-3d37o05y	4	4	10604	10604	CD
cord-010604-3d37o05y	4	5	cord_uid	cord_uid	NNS
cord-010604-3d37o05y	4	6	:	:	:
cord-010604-3d37o05y	5	1	3d37o05y	3d37o05y	CD
cord-010604-3d37o05y	5	2	Adaptation	adaptation	NN
cord-010604-3d37o05y	5	3	to	to	IN
cord-010604-3d37o05y	5	4	stress	stress	NN
cord-010604-3d37o05y	5	5	is	be	VBZ
cord-010604-3d37o05y	5	6	a	a	DT
cord-010604-3d37o05y	5	7	fundamental	fundamental	JJ
cord-010604-3d37o05y	5	8	requirement	requirement	NN
cord-010604-3d37o05y	5	9	to	to	TO
cord-010604-3d37o05y	5	10	cope	cope	VB
cord-010604-3d37o05y	5	11	with	with	IN
cord-010604-3d37o05y	5	12	changing	change	VBG
cord-010604-3d37o05y	5	13	environmental	environmental	JJ
cord-010604-3d37o05y	5	14	conditions	condition	NNS
cord-010604-3d37o05y	5	15	that	that	WDT
cord-010604-3d37o05y	5	16	pose	pose	VBP
cord-010604-3d37o05y	5	17	a	a	DT
cord-010604-3d37o05y	5	18	threat	threat	NN
cord-010604-3d37o05y	5	19	to	to	IN
cord-010604-3d37o05y	5	20	the	the	DT
cord-010604-3d37o05y	5	21	homeostasis	homeostasis	NN
cord-010604-3d37o05y	5	22	of	of	IN
cord-010604-3d37o05y	5	23	cells	cell	NNS
cord-010604-3d37o05y	5	24	and	and	CC
cord-010604-3d37o05y	5	25	organisms	organism	NNS
cord-010604-3d37o05y	5	26	.	.	.
cord-010604-3d37o05y	6	1	Post	post	JJ
cord-010604-3d37o05y	6	2	-	-	JJ
cord-010604-3d37o05y	6	3	translational	translational	JJ
cord-010604-3d37o05y	6	4	modifications	modification	NNS
cord-010604-3d37o05y	6	5	(	(	-LRB-
cord-010604-3d37o05y	6	6	PTMs	ptm	NNS
cord-010604-3d37o05y	6	7	)	)	-RRB-
cord-010604-3d37o05y	6	8	of	of	IN
cord-010604-3d37o05y	6	9	proteins	protein	NNS
cord-010604-3d37o05y	6	10	represent	represent	VBP
cord-010604-3d37o05y	6	11	a	a	DT
cord-010604-3d37o05y	6	12	possibility	possibility	NN
cord-010604-3d37o05y	6	13	to	to	TO
cord-010604-3d37o05y	6	14	quickly	quickly	RB
cord-010604-3d37o05y	6	15	produce	produce	VB
cord-010604-3d37o05y	6	16	proteins	protein	NNS
cord-010604-3d37o05y	6	17	with	with	IN
cord-010604-3d37o05y	6	18	new	new	JJ
cord-010604-3d37o05y	6	19	features	feature	NNS
cord-010604-3d37o05y	6	20	demanding	demand	VBG
cord-010604-3d37o05y	6	21	relatively	relatively	RB
cord-010604-3d37o05y	6	22	little	little	JJ
cord-010604-3d37o05y	6	23	cellular	cellular	JJ
cord-010604-3d37o05y	6	24	resources	resource	NNS
cord-010604-3d37o05y	6	25	.	.	.
cord-010604-3d37o05y	7	1	FK506	fk506	JJ
cord-010604-3d37o05y	7	2	binding	bind	VBG
cord-010604-3d37o05y	7	3	protein	protein	NN
cord-010604-3d37o05y	7	4	(	(	-LRB-
cord-010604-3d37o05y	7	5	FKBP	FKBP	NNP
cord-010604-3d37o05y	7	6	)	)	-RRB-
cord-010604-3d37o05y	7	7	51	51	CD
cord-010604-3d37o05y	7	8	is	be	VBZ
cord-010604-3d37o05y	7	9	a	a	DT
cord-010604-3d37o05y	7	10	pivotal	pivotal	JJ
cord-010604-3d37o05y	7	11	stress	stress	NN
cord-010604-3d37o05y	7	12	protein	protein	NN
cord-010604-3d37o05y	7	13	that	that	WDT
cord-010604-3d37o05y	7	14	is	be	VBZ
cord-010604-3d37o05y	7	15	involved	involve	VBN
cord-010604-3d37o05y	7	16	in	in	IN
cord-010604-3d37o05y	7	17	the	the	DT
cord-010604-3d37o05y	7	18	regulation	regulation	NN
cord-010604-3d37o05y	7	19	of	of	IN
cord-010604-3d37o05y	7	20	several	several	JJ
cord-010604-3d37o05y	7	21	executers	executer	NNS
cord-010604-3d37o05y	7	22	of	of	IN
cord-010604-3d37o05y	7	23	PTMs	ptm	NNS
cord-010604-3d37o05y	7	24	.	.	.
cord-010604-3d37o05y	8	1	This	this	DT
cord-010604-3d37o05y	8	2	mini	mini	JJ
cord-010604-3d37o05y	8	3	-	-	NN
cord-010604-3d37o05y	8	4	review	review	NN
cord-010604-3d37o05y	8	5	discusses	discuss	VBZ
cord-010604-3d37o05y	8	6	the	the	DT
cord-010604-3d37o05y	8	7	role	role	NN
cord-010604-3d37o05y	8	8	of	of	IN
cord-010604-3d37o05y	8	9	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	8	10	in	in	IN
cord-010604-3d37o05y	8	11	the	the	DT
cord-010604-3d37o05y	8	12	function	function	NN
cord-010604-3d37o05y	8	13	of	of	IN
cord-010604-3d37o05y	8	14	proteins	protein	NNS
cord-010604-3d37o05y	8	15	responsible	responsible	JJ
cord-010604-3d37o05y	8	16	for	for	IN
cord-010604-3d37o05y	8	17	setting	set	VBG
cord-010604-3d37o05y	8	18	the	the	DT
cord-010604-3d37o05y	8	19	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	8	20	,	,	,
cord-010604-3d37o05y	8	21	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	8	22	and	and	CC
cord-010604-3d37o05y	8	23	lipidation	lipidation	NN
cord-010604-3d37o05y	8	24	of	of	IN
cord-010604-3d37o05y	8	25	other	other	JJ
cord-010604-3d37o05y	8	26	proteins	protein	NNS
cord-010604-3d37o05y	8	27	.	.	.
cord-010604-3d37o05y	9	1	Examples	example	NNS
cord-010604-3d37o05y	9	2	include	include	VBP
cord-010604-3d37o05y	9	3	the	the	DT
cord-010604-3d37o05y	9	4	kinases	kinase	NNS
cord-010604-3d37o05y	9	5	Akt1	Akt1	NNP
cord-010604-3d37o05y	9	6	,	,	,
cord-010604-3d37o05y	9	7	CDK5	CDK5	NNP
cord-010604-3d37o05y	9	8	and	and	CC
cord-010604-3d37o05y	9	9	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	9	10	,	,	,
cord-010604-3d37o05y	9	11	the	the	DT
cord-010604-3d37o05y	9	12	phosphatases	phosphatase	NNS
cord-010604-3d37o05y	9	13	calcineurin	calcineurin	NNP
cord-010604-3d37o05y	9	14	,	,	,
cord-010604-3d37o05y	9	15	PP2A	PP2A	NNP
cord-010604-3d37o05y	9	16	and	and	CC
cord-010604-3d37o05y	9	17	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	9	18	,	,	,
cord-010604-3d37o05y	9	19	and	and	CC
cord-010604-3d37o05y	9	20	the	the	DT
cord-010604-3d37o05y	9	21	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	9	22	E3-ligase	E3-ligase	NNP
cord-010604-3d37o05y	9	23	SKP2	SKP2	NNP
cord-010604-3d37o05y	9	24	.	.	.
cord-010604-3d37o05y	10	1	The	the	DT
cord-010604-3d37o05y	10	2	impact	impact	NN
cord-010604-3d37o05y	10	3	of	of	IN
cord-010604-3d37o05y	10	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	10	5	on	on	IN
cord-010604-3d37o05y	10	6	PTMs	ptm	NNS
cord-010604-3d37o05y	10	7	of	of	IN
cord-010604-3d37o05y	10	8	signal	signal	NN
cord-010604-3d37o05y	10	9	transduction	transduction	NN
cord-010604-3d37o05y	10	10	proteins	protein	NNS
cord-010604-3d37o05y	10	11	significantly	significantly	RB
cord-010604-3d37o05y	10	12	extends	extend	VBZ
cord-010604-3d37o05y	10	13	the	the	DT
cord-010604-3d37o05y	10	14	functional	functional	JJ
cord-010604-3d37o05y	10	15	versatility	versatility	NN
cord-010604-3d37o05y	10	16	of	of	IN
cord-010604-3d37o05y	10	17	this	this	DT
cord-010604-3d37o05y	10	18	protein	protein	NN
cord-010604-3d37o05y	10	19	.	.	.
cord-010604-3d37o05y	11	1	As	as	IN
cord-010604-3d37o05y	11	2	a	a	DT
cord-010604-3d37o05y	11	3	stress	stress	NN
cord-010604-3d37o05y	11	4	-	-	HYPH
cord-010604-3d37o05y	11	5	induced	induce	VBN
cord-010604-3d37o05y	11	6	protein	protein	NN
cord-010604-3d37o05y	11	7	,	,	,
cord-010604-3d37o05y	11	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	11	9	uses	use	VBZ
cord-010604-3d37o05y	11	10	re	re	NN
cord-010604-3d37o05y	11	11	-	-	NN
cord-010604-3d37o05y	11	12	setting	setting	NN
cord-010604-3d37o05y	11	13	of	of	IN
cord-010604-3d37o05y	11	14	PTMs	ptm	NNS
cord-010604-3d37o05y	11	15	to	to	TO
cord-010604-3d37o05y	11	16	relay	relay	VB
cord-010604-3d37o05y	11	17	the	the	DT
cord-010604-3d37o05y	11	18	effect	effect	NN
cord-010604-3d37o05y	11	19	of	of	IN
cord-010604-3d37o05y	11	20	stress	stress	NN
cord-010604-3d37o05y	11	21	on	on	IN
cord-010604-3d37o05y	11	22	various	various	JJ
cord-010604-3d37o05y	11	23	signaling	signal	VBG
cord-010604-3d37o05y	11	24	pathways	pathway	NNS
cord-010604-3d37o05y	11	25	.	.	.
cord-010604-3d37o05y	12	1	The	the	DT
cord-010604-3d37o05y	12	2	physiological	physiological	JJ
cord-010604-3d37o05y	12	3	stress	stress	NN
cord-010604-3d37o05y	12	4	response	response	NN
cord-010604-3d37o05y	12	5	is	be	VBZ
cord-010604-3d37o05y	12	6	elicited	elicit	VBN
cord-010604-3d37o05y	12	7	whenever	whenever	WRB
cord-010604-3d37o05y	12	8	a	a	DT
cord-010604-3d37o05y	12	9	change	change	NN
cord-010604-3d37o05y	12	10	in	in	IN
cord-010604-3d37o05y	12	11	the	the	DT
cord-010604-3d37o05y	12	12	environment	environment	NN
cord-010604-3d37o05y	12	13	is	be	VBZ
cord-010604-3d37o05y	12	14	sensed	sense	VBN
cord-010604-3d37o05y	12	15	and	and	CC
cord-010604-3d37o05y	12	16	interpreted	interpret	VBN
cord-010604-3d37o05y	12	17	as	as	IN
cord-010604-3d37o05y	12	18	threat	threat	NN
cord-010604-3d37o05y	12	19	to	to	IN
cord-010604-3d37o05y	12	20	homeostasis	homeostasis	NN
cord-010604-3d37o05y	12	21	.	.	.
cord-010604-3d37o05y	13	1	Effector	Effector	NNP
cord-010604-3d37o05y	13	2	systems	system	NNS
cord-010604-3d37o05y	13	3	comprise	comprise	VBP
cord-010604-3d37o05y	13	4	the	the	DT
cord-010604-3d37o05y	13	5	autonomic	autonomic	JJ
cord-010604-3d37o05y	13	6	nervous	nervous	JJ
cord-010604-3d37o05y	13	7	system	system	NN
cord-010604-3d37o05y	13	8	and	and	CC
cord-010604-3d37o05y	13	9	the	the	DT
cord-010604-3d37o05y	13	10	hypothalamic	hypothalamic	JJ
cord-010604-3d37o05y	13	11	-	-	HYPH
cord-010604-3d37o05y	13	12	pituitary	pituitary	NN
cord-010604-3d37o05y	13	13	-	-	HYPH
cord-010604-3d37o05y	13	14	adrenocortical	adrenocortical	NN
cord-010604-3d37o05y	13	15	(	(	-LRB-
cord-010604-3d37o05y	13	16	HPA	HPA	NNP
cord-010604-3d37o05y	13	17	)	)	-RRB-
cord-010604-3d37o05y	13	18	axis	axis	NN
cord-010604-3d37o05y	13	19	[	[	-LRB-
cord-010604-3d37o05y	13	20	1	1	CD
cord-010604-3d37o05y	13	21	]	]	-RRB-
cord-010604-3d37o05y	13	22	.	.	.
cord-010604-3d37o05y	14	1	The	the	DT
cord-010604-3d37o05y	14	2	effector	effector	JJ
cord-010604-3d37o05y	14	3	molecules	molecule	NNS
cord-010604-3d37o05y	14	4	of	of	IN
cord-010604-3d37o05y	14	5	these	these	DT
cord-010604-3d37o05y	14	6	systems	system	NNS
cord-010604-3d37o05y	14	7	are	be	VBP
cord-010604-3d37o05y	14	8	noradrenaline	noradrenaline	NN
cord-010604-3d37o05y	14	9	and	and	CC
cord-010604-3d37o05y	14	10	adrenaline	adrenaline	NN
cord-010604-3d37o05y	14	11	for	for	IN
cord-010604-3d37o05y	14	12	the	the	DT
cord-010604-3d37o05y	14	13	autonomic	autonomic	JJ
cord-010604-3d37o05y	14	14	nervous	nervous	JJ
cord-010604-3d37o05y	14	15	system	system	NN
cord-010604-3d37o05y	14	16	,	,	,
cord-010604-3d37o05y	14	17	and	and	CC
cord-010604-3d37o05y	14	18	cortisol	cortisol	NN
cord-010604-3d37o05y	14	19	for	for	IN
cord-010604-3d37o05y	14	20	the	the	DT
cord-010604-3d37o05y	14	21	HPA	HPA	NNP
cord-010604-3d37o05y	14	22	axis	axis	NN
cord-010604-3d37o05y	14	23	(	(	-LRB-
cord-010604-3d37o05y	14	24	corticosterone	corticosterone	NN
cord-010604-3d37o05y	14	25	in	in	IN
cord-010604-3d37o05y	14	26	rodents	rodent	NNS
cord-010604-3d37o05y	14	27	)	)	-RRB-
cord-010604-3d37o05y	14	28	.	.	.
cord-010604-3d37o05y	15	1	Adrenaline	adrenaline	NN
cord-010604-3d37o05y	15	2	and	and	CC
cord-010604-3d37o05y	15	3	noradrenaline	noradrenaline	NN
cord-010604-3d37o05y	15	4	act	act	NN
cord-010604-3d37o05y	15	5	through	through	IN
cord-010604-3d37o05y	15	6	G	G	NNP
cord-010604-3d37o05y	15	7	protein	protein	NN
cord-010604-3d37o05y	15	8	-	-	HYPH
cord-010604-3d37o05y	15	9	coupled	couple	VBN
cord-010604-3d37o05y	15	10	receptors	receptor	NNS
cord-010604-3d37o05y	15	11	that	that	WDT
cord-010604-3d37o05y	15	12	are	be	VBP
cord-010604-3d37o05y	15	13	hooked	hooked	JJ
cord-010604-3d37o05y	15	14	to	to	IN
cord-010604-3d37o05y	15	15	various	various	JJ
cord-010604-3d37o05y	15	16	intracellular	intracellular	JJ
cord-010604-3d37o05y	15	17	pathways	pathway	NNS
cord-010604-3d37o05y	15	18	involving	involve	VBG
cord-010604-3d37o05y	15	19	determinants	determinant	NNS
cord-010604-3d37o05y	15	20	of	of	IN
cord-010604-3d37o05y	15	21	post	post	JJ
cord-010604-3d37o05y	15	22	-	-	JJ
cord-010604-3d37o05y	15	23	translational	translational	JJ
cord-010604-3d37o05y	15	24	modifications	modification	NNS
cord-010604-3d37o05y	15	25	(	(	-LRB-
cord-010604-3d37o05y	15	26	PTMs	ptm	NNS
cord-010604-3d37o05y	15	27	)	)	-RRB-
cord-010604-3d37o05y	15	28	such	such	JJ
cord-010604-3d37o05y	15	29	as	as	IN
cord-010604-3d37o05y	15	30	kinases	kinase	NNS
cord-010604-3d37o05y	15	31	and	and	CC
cord-010604-3d37o05y	15	32	phosphatases	phosphatase	NNS
cord-010604-3d37o05y	15	33	[	[	-LRB-
cord-010604-3d37o05y	15	34	2	2	CD
cord-010604-3d37o05y	15	35	]	]	-RRB-
cord-010604-3d37o05y	15	36	.	.	.
cord-010604-3d37o05y	16	1	These	these	DT
cord-010604-3d37o05y	16	2	determinants	determinant	NNS
cord-010604-3d37o05y	16	3	are	be	VBP
cord-010604-3d37o05y	16	4	also	also	RB
cord-010604-3d37o05y	16	5	referred	refer	VBN
cord-010604-3d37o05y	16	6	to	to	IN
cord-010604-3d37o05y	16	7	as	as	IN
cord-010604-3d37o05y	16	8	'	'	``
cord-010604-3d37o05y	16	9	writers	writer	NNS
cord-010604-3d37o05y	16	10	'	'	POS
cord-010604-3d37o05y	16	11	and	and	CC
cord-010604-3d37o05y	16	12	'	'	``
cord-010604-3d37o05y	16	13	erases	erase	VBZ
cord-010604-3d37o05y	16	14	'	'	''
cord-010604-3d37o05y	16	15	of	of	IN
cord-010604-3d37o05y	16	16	PTMs	ptm	NNS
cord-010604-3d37o05y	16	17	[	[	-LRB-
cord-010604-3d37o05y	16	18	3	3	CD
cord-010604-3d37o05y	16	19	,	,	,
cord-010604-3d37o05y	16	20	4	4	CD
cord-010604-3d37o05y	16	21	]	]	-RRB-
cord-010604-3d37o05y	16	22	.	.	.
cord-010604-3d37o05y	17	1	Using	use	VBG
cord-010604-3d37o05y	17	2	PTMs	ptm	NNS
cord-010604-3d37o05y	17	3	for	for	IN
cord-010604-3d37o05y	17	4	signal	signal	NN
cord-010604-3d37o05y	17	5	transduction	transduction	NN
cord-010604-3d37o05y	17	6	comes	come	VBZ
cord-010604-3d37o05y	17	7	with	with	IN
cord-010604-3d37o05y	17	8	the	the	DT
cord-010604-3d37o05y	17	9	obvious	obvious	JJ
cord-010604-3d37o05y	17	10	advantage	advantage	NN
cord-010604-3d37o05y	17	11	of	of	IN
cord-010604-3d37o05y	17	12	allowing	allow	VBG
cord-010604-3d37o05y	17	13	for	for	IN
cord-010604-3d37o05y	17	14	quickly	quickly	RB
cord-010604-3d37o05y	17	15	changing	change	VBG
cord-010604-3d37o05y	17	16	the	the	DT
cord-010604-3d37o05y	17	17	mode	mode	NN
cord-010604-3d37o05y	17	18	of	of	IN
cord-010604-3d37o05y	17	19	action	action	NN
cord-010604-3d37o05y	17	20	of	of	IN
cord-010604-3d37o05y	17	21	pre	pre	JJ
cord-010604-3d37o05y	17	22	-	-	JJ
cord-010604-3d37o05y	17	23	synthesized	synthesize	VBN
cord-010604-3d37o05y	17	24	proteins	protein	NNS
cord-010604-3d37o05y	17	25	in	in	IN
cord-010604-3d37o05y	17	26	a	a	DT
cord-010604-3d37o05y	17	27	vast	vast	JJ
cord-010604-3d37o05y	17	28	functional	functional	JJ
cord-010604-3d37o05y	17	29	space	space	NN
cord-010604-3d37o05y	17	30	defined	define	VBN
cord-010604-3d37o05y	17	31	by	by	IN
cord-010604-3d37o05y	17	32	the	the	DT
cord-010604-3d37o05y	17	33	huge	huge	JJ
cord-010604-3d37o05y	17	34	number	number	NN
cord-010604-3d37o05y	17	35	of	of	IN
cord-010604-3d37o05y	17	36	possible	possible	JJ
cord-010604-3d37o05y	17	37	combinations	combination	NNS
cord-010604-3d37o05y	17	38	of	of	IN
cord-010604-3d37o05y	17	39	PTMs	ptm	NNS
cord-010604-3d37o05y	17	40	at	at	IN
cord-010604-3d37o05y	17	41	different	different	JJ
cord-010604-3d37o05y	17	42	amino	amino	NN
cord-010604-3d37o05y	17	43	acids	acid	NNS
cord-010604-3d37o05y	17	44	[	[	-LRB-
cord-010604-3d37o05y	17	45	4	4	CD
cord-010604-3d37o05y	17	46	,	,	,
cord-010604-3d37o05y	17	47	5	5	CD
cord-010604-3d37o05y	17	48	]	]	-RRB-
cord-010604-3d37o05y	17	49	.	.	.
cord-010604-3d37o05y	18	1	Moreover	moreover	RB
cord-010604-3d37o05y	18	2	,	,	,
cord-010604-3d37o05y	18	3	PTMs	ptm	NNS
cord-010604-3d37o05y	18	4	are	be	VBP
cord-010604-3d37o05y	18	5	reversible	reversible	JJ
cord-010604-3d37o05y	18	6	at	at	IN
cord-010604-3d37o05y	18	7	a	a	DT
cord-010604-3d37o05y	18	8	small	small	JJ
cord-010604-3d37o05y	18	9	time	time	NN
cord-010604-3d37o05y	18	10	scale	scale	NN
cord-010604-3d37o05y	18	11	,	,	,
cord-010604-3d37o05y	18	12	which	which	WDT
cord-010604-3d37o05y	18	13	is	be	VBZ
cord-010604-3d37o05y	18	14	another	another	DT
cord-010604-3d37o05y	18	15	important	important	JJ
cord-010604-3d37o05y	18	16	feature	feature	NN
cord-010604-3d37o05y	18	17	for	for	IN
cord-010604-3d37o05y	18	18	the	the	DT
cord-010604-3d37o05y	18	19	stress	stress	NN
cord-010604-3d37o05y	18	20	response	response	NN
cord-010604-3d37o05y	18	21	,	,	,
cord-010604-3d37o05y	18	22	in	in	IN
cord-010604-3d37o05y	18	23	particular	particular	JJ
cord-010604-3d37o05y	18	24	when	when	WRB
cord-010604-3d37o05y	18	25	stress	stress	NN
cord-010604-3d37o05y	18	26	exposure	exposure	NN
cord-010604-3d37o05y	18	27	is	be	VBZ
cord-010604-3d37o05y	18	28	short	short	JJ
cord-010604-3d37o05y	18	29	[	[	-LRB-
cord-010604-3d37o05y	18	30	5	5	CD
cord-010604-3d37o05y	18	31	]	]	-RRB-
cord-010604-3d37o05y	18	32	.	.	.
cord-010604-3d37o05y	19	1	The	the	DT
cord-010604-3d37o05y	19	2	HPA	HPA	NNP
cord-010604-3d37o05y	19	3	axis	axis	NN
cord-010604-3d37o05y	19	4	also	also	RB
cord-010604-3d37o05y	19	5	activates	activate	VBZ
cord-010604-3d37o05y	19	6	G	g	NN
cord-010604-3d37o05y	19	7	protein	protein	NN
cord-010604-3d37o05y	19	8	-	-	HYPH
cord-010604-3d37o05y	19	9	coupled	couple	VBN
cord-010604-3d37o05y	19	10	receptors	receptor	NNS
cord-010604-3d37o05y	19	11	,	,	,
cord-010604-3d37o05y	19	12	namely	namely	RB
cord-010604-3d37o05y	19	13	the	the	DT
cord-010604-3d37o05y	19	14	receptors	receptor	NNS
cord-010604-3d37o05y	19	15	for	for	IN
cord-010604-3d37o05y	19	16	the	the	DT
cord-010604-3d37o05y	19	17	hormones	hormone	NNS
cord-010604-3d37o05y	19	18	corticotropin	corticotropin	NNP
cord-010604-3d37o05y	19	19	-	-	HYPH
cord-010604-3d37o05y	19	20	releasing	release	VBG
cord-010604-3d37o05y	19	21	factor	factor	NN
cord-010604-3d37o05y	19	22	and	and	CC
cord-010604-3d37o05y	19	23	adenocorticotropic	adenocorticotropic	NNP
cord-010604-3d37o05y	19	24	hormone	hormone	NN
cord-010604-3d37o05y	19	25	[	[	-LRB-
cord-010604-3d37o05y	19	26	1	1	CD
cord-010604-3d37o05y	19	27	]	]	-RRB-
cord-010604-3d37o05y	19	28	.	.	.
cord-010604-3d37o05y	20	1	However	however	RB
cord-010604-3d37o05y	20	2	,	,	,
cord-010604-3d37o05y	20	3	its	-PRON-	PRP$
cord-010604-3d37o05y	20	4	final	final	JJ
cord-010604-3d37o05y	20	5	effector	effector	NN
cord-010604-3d37o05y	20	6	cortisol	cortisol	NN
cord-010604-3d37o05y	20	7	operates	operate	VBZ
cord-010604-3d37o05y	20	8	through	through	IN
cord-010604-3d37o05y	20	9	the	the	DT
cord-010604-3d37o05y	20	10	steroid	steroid	NN
cord-010604-3d37o05y	20	11	receptors	receptor	NNS
cord-010604-3d37o05y	20	12	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	20	13	receptor	receptor	NN
cord-010604-3d37o05y	20	14	(	(	-LRB-
cord-010604-3d37o05y	20	15	GR	GR	NNP
cord-010604-3d37o05y	20	16	)	)	-RRB-
cord-010604-3d37o05y	20	17	and	and	CC
cord-010604-3d37o05y	20	18	mineralocorticoid	mineralocorticoid	NN
cord-010604-3d37o05y	20	19	receptor	receptor	NN
cord-010604-3d37o05y	20	20	[	[	-LRB-
cord-010604-3d37o05y	20	21	6	6	CD
cord-010604-3d37o05y	20	22	]	]	-RRB-
cord-010604-3d37o05y	20	23	.	.	.
cord-010604-3d37o05y	21	1	These	these	DT
cord-010604-3d37o05y	21	2	receptors	receptor	NNS
cord-010604-3d37o05y	21	3	are	be	VBP
cord-010604-3d37o05y	21	4	transcription	transcription	NN
cord-010604-3d37o05y	21	5	factors	factor	NNS
cord-010604-3d37o05y	21	6	,	,	,
cord-010604-3d37o05y	21	7	and	and	CC
cord-010604-3d37o05y	21	8	thus	thus	RB
cord-010604-3d37o05y	21	9	this	this	DT
cord-010604-3d37o05y	21	10	part	part	NN
cord-010604-3d37o05y	21	11	of	of	IN
cord-010604-3d37o05y	21	12	the	the	DT
cord-010604-3d37o05y	21	13	overall	overall	JJ
cord-010604-3d37o05y	21	14	stress	stress	NN
cord-010604-3d37o05y	21	15	response	response	NN
cord-010604-3d37o05y	21	16	typically	typically	RB
cord-010604-3d37o05y	21	17	takes	take	VBZ
cord-010604-3d37o05y	21	18	longer	long	RBR
cord-010604-3d37o05y	21	19	than	than	IN
cord-010604-3d37o05y	21	20	the	the	DT
cord-010604-3d37o05y	21	21	time	time	NN
cord-010604-3d37o05y	21	22	required	require	VBN
cord-010604-3d37o05y	21	23	to	to	TO
cord-010604-3d37o05y	21	24	redefine	redefine	VB
cord-010604-3d37o05y	21	25	the	the	DT
cord-010604-3d37o05y	21	26	function	function	NN
cord-010604-3d37o05y	21	27	of	of	IN
cord-010604-3d37o05y	21	28	proteins	protein	NNS
cord-010604-3d37o05y	21	29	through	through	IN
cord-010604-3d37o05y	21	30	re	re	NN
cord-010604-3d37o05y	21	31	-	-	JJ
cord-010604-3d37o05y	21	32	setting	set	VBG
cord-010604-3d37o05y	21	33	their	-PRON-	PRP$
cord-010604-3d37o05y	21	34	PTMs	ptm	NNS
cord-010604-3d37o05y	21	35	.	.	.
cord-010604-3d37o05y	22	1	Nevertheless	nevertheless	RB
cord-010604-3d37o05y	22	2	,	,	,
cord-010604-3d37o05y	22	3	the	the	DT
cord-010604-3d37o05y	22	4	action	action	NN
cord-010604-3d37o05y	22	5	of	of	IN
cord-010604-3d37o05y	22	6	these	these	DT
cord-010604-3d37o05y	22	7	receptors	receptor	NNS
cord-010604-3d37o05y	22	8	also	also	RB
cord-010604-3d37o05y	22	9	is	be	VBZ
cord-010604-3d37o05y	22	10	intertwined	intertwine	VBN
cord-010604-3d37o05y	22	11	with	with	IN
cord-010604-3d37o05y	22	12	PTMs	ptm	NNS
cord-010604-3d37o05y	22	13	:	:	:
cord-010604-3d37o05y	22	14	they	-PRON-	PRP
cord-010604-3d37o05y	22	15	are	be	VBP
cord-010604-3d37o05y	22	16	subject	subject	JJ
cord-010604-3d37o05y	22	17	to	to	IN
cord-010604-3d37o05y	22	18	regulation	regulation	NN
cord-010604-3d37o05y	22	19	by	by	IN
cord-010604-3d37o05y	22	20	PTMs	ptm	NNS
cord-010604-3d37o05y	22	21	and	and	CC
cord-010604-3d37o05y	22	22	they	-PRON-	PRP
cord-010604-3d37o05y	22	23	impact	impact	VBP
cord-010604-3d37o05y	22	24	writers	writer	NNS
cord-010604-3d37o05y	22	25	and	and	CC
cord-010604-3d37o05y	22	26	erasers	eraser	NNS
cord-010604-3d37o05y	22	27	of	of	IN
cord-010604-3d37o05y	22	28	PTMs	ptm	NNS
cord-010604-3d37o05y	22	29	[	[	-LRB-
cord-010604-3d37o05y	22	30	7	7	CD
cord-010604-3d37o05y	22	31	]	]	-RRB-
cord-010604-3d37o05y	23	1	[	[	-LRB-
cord-010604-3d37o05y	23	2	8	8	CD
cord-010604-3d37o05y	23	3	]	]	-RRB-
cord-010604-3d37o05y	23	4	[	[	-LRB-
cord-010604-3d37o05y	23	5	9	9	CD
cord-010604-3d37o05y	23	6	]	]	-RRB-
cord-010604-3d37o05y	23	7	.	.	.
cord-010604-3d37o05y	24	1	In	in	IN
cord-010604-3d37o05y	24	2	part	part	NN
cord-010604-3d37o05y	24	3	,	,	,
cord-010604-3d37o05y	24	4	this	this	DT
cord-010604-3d37o05y	24	5	is	be	VBZ
cord-010604-3d37o05y	24	6	achieved	achieve	VBN
cord-010604-3d37o05y	24	7	through	through	IN
cord-010604-3d37o05y	24	8	the	the	DT
cord-010604-3d37o05y	24	9	synthesis	synthesis	NN
cord-010604-3d37o05y	24	10	of	of	IN
cord-010604-3d37o05y	24	11	specific	specific	JJ
cord-010604-3d37o05y	24	12	proteins	protein	NNS
cord-010604-3d37o05y	24	13	that	that	WDT
cord-010604-3d37o05y	24	14	take	take	VBP
cord-010604-3d37o05y	24	15	part	part	NN
cord-010604-3d37o05y	24	16	in	in	IN
cord-010604-3d37o05y	24	17	the	the	DT
cord-010604-3d37o05y	24	18	orchestration	orchestration	NN
cord-010604-3d37o05y	24	19	of	of	IN
cord-010604-3d37o05y	24	20	proteome	proteome	NN
cord-010604-3d37o05y	24	21	function	function	NN
cord-010604-3d37o05y	24	22	through	through	IN
cord-010604-3d37o05y	24	23	PTMs	ptm	NNS
cord-010604-3d37o05y	24	24	.	.	.
cord-010604-3d37o05y	25	1	FK506	fk506	JJ
cord-010604-3d37o05y	25	2	binding	bind	VBG
cord-010604-3d37o05y	25	3	protein	protein	NN
cord-010604-3d37o05y	25	4	(	(	-LRB-
cord-010604-3d37o05y	25	5	FKBP	FKBP	NNP
cord-010604-3d37o05y	25	6	)	)	-RRB-
cord-010604-3d37o05y	25	7	51	51	CD
cord-010604-3d37o05y	25	8	turned	turn	VBD
cord-010604-3d37o05y	25	9	out	out	RP
cord-010604-3d37o05y	25	10	to	to	TO
cord-010604-3d37o05y	25	11	be	be	VB
cord-010604-3d37o05y	25	12	one	one	CD
cord-010604-3d37o05y	25	13	of	of	IN
cord-010604-3d37o05y	25	14	these	these	DT
cord-010604-3d37o05y	25	15	proteins	protein	NNS
cord-010604-3d37o05y	25	16	which	which	WDT
cord-010604-3d37o05y	25	17	is	be	VBZ
cord-010604-3d37o05y	25	18	subject	subject	JJ
cord-010604-3d37o05y	25	19	of	of	IN
cord-010604-3d37o05y	25	20	this	this	DT
cord-010604-3d37o05y	25	21	review	review	NN
cord-010604-3d37o05y	25	22	.	.	.
cord-010604-3d37o05y	26	1	The	the	DT
cord-010604-3d37o05y	26	2	stress	stress	NN
cord-010604-3d37o05y	26	3	protein	protein	NN
cord-010604-3d37o05y	26	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	26	5	,	,	,
cord-010604-3d37o05y	26	6	promoted	promote	VBN
cord-010604-3d37o05y	26	7	through	through	IN
cord-010604-3d37o05y	26	8	translational	translational	JJ
cord-010604-3d37o05y	26	9	research	research	NN
cord-010604-3d37o05y	26	10	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	26	11	is	be	VBZ
cord-010604-3d37o05y	26	12	a	a	DT
cord-010604-3d37o05y	26	13	show	show	NN
cord-010604-3d37o05y	26	14	-	-	HYPH
cord-010604-3d37o05y	26	15	case	case	NN
cord-010604-3d37o05y	26	16	of	of	IN
cord-010604-3d37o05y	26	17	translational	translational	JJ
cord-010604-3d37o05y	26	18	research	research	NN
cord-010604-3d37o05y	26	19	where	where	WRB
cord-010604-3d37o05y	26	20	clinical	clinical	JJ
cord-010604-3d37o05y	26	21	and	and	CC
cord-010604-3d37o05y	26	22	basic	basic	JJ
cord-010604-3d37o05y	26	23	science	science	NN
cord-010604-3d37o05y	26	24	approaches	approach	NNS
cord-010604-3d37o05y	26	25	stimulated	stimulate	VBD
cord-010604-3d37o05y	26	26	each	each	DT
cord-010604-3d37o05y	26	27	other	other	JJ
cord-010604-3d37o05y	26	28	.	.	.
cord-010604-3d37o05y	27	1	The	the	DT
cord-010604-3d37o05y	27	2	background	background	NN
cord-010604-3d37o05y	27	3	of	of	IN
cord-010604-3d37o05y	27	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	27	5	is	be	VBZ
cord-010604-3d37o05y	27	6	laid	lay	VBN
cord-010604-3d37o05y	27	7	out	out	RP
cord-010604-3d37o05y	27	8	here	here	RB
cord-010604-3d37o05y	27	9	only	only	RB
cord-010604-3d37o05y	27	10	shortly	shortly	RB
cord-010604-3d37o05y	27	11	,	,	,
cord-010604-3d37o05y	27	12	and	and	CC
cord-010604-3d37o05y	27	13	the	the	DT
cord-010604-3d37o05y	27	14	reader	reader	NN
cord-010604-3d37o05y	27	15	is	be	VBZ
cord-010604-3d37o05y	27	16	referred	refer	VBN
cord-010604-3d37o05y	27	17	to	to	IN
cord-010604-3d37o05y	27	18	the	the	DT
cord-010604-3d37o05y	27	19	numerous	numerous	JJ
cord-010604-3d37o05y	27	20	recent	recent	JJ
cord-010604-3d37o05y	27	21	reviews	review	NNS
cord-010604-3d37o05y	27	22	for	for	IN
cord-010604-3d37o05y	27	23	more	more	RBR
cord-010604-3d37o05y	27	24	detailed	detailed	JJ
cord-010604-3d37o05y	27	25	information	information	NN
cord-010604-3d37o05y	27	26	[	[	-LRB-
cord-010604-3d37o05y	27	27	10	10	CD
cord-010604-3d37o05y	27	28	]	]	-RRB-
cord-010604-3d37o05y	28	1	[	[	-LRB-
cord-010604-3d37o05y	28	2	11	11	CD
cord-010604-3d37o05y	28	3	]	]	-RRB-
cord-010604-3d37o05y	28	4	[	[	-LRB-
cord-010604-3d37o05y	28	5	12	12	CD
cord-010604-3d37o05y	28	6	]	]	-RRB-
cord-010604-3d37o05y	28	7	[	[	-LRB-
cord-010604-3d37o05y	28	8	13	13	CD
cord-010604-3d37o05y	28	9	]	]	-RRB-
cord-010604-3d37o05y	29	1	[	[	-LRB-
cord-010604-3d37o05y	29	2	14	14	CD
cord-010604-3d37o05y	29	3	]	]	-RRB-
cord-010604-3d37o05y	29	4	[	[	-LRB-
cord-010604-3d37o05y	29	5	15	15	CD
cord-010604-3d37o05y	29	6	]	]	-RRB-
cord-010604-3d37o05y	29	7	.	.	.
cord-010604-3d37o05y	30	1	Originally	originally	RB
cord-010604-3d37o05y	30	2	discovered	discover	VBN
cord-010604-3d37o05y	30	3	as	as	IN
cord-010604-3d37o05y	30	4	part	part	NN
cord-010604-3d37o05y	30	5	of	of	IN
cord-010604-3d37o05y	30	6	steroid	steroid	JJ
cord-010604-3d37o05y	30	7	receptor	receptor	NN
cord-010604-3d37o05y	30	8	-	-	HYPH
cord-010604-3d37o05y	30	9	heat	heat	NN
cord-010604-3d37o05y	30	10	shock	shock	NN
cord-010604-3d37o05y	30	11	protein	protein	NN
cord-010604-3d37o05y	30	12	90	90	CD
cord-010604-3d37o05y	30	13	hetero	hetero	NNS
cord-010604-3d37o05y	30	14	-	-	NNS
cord-010604-3d37o05y	30	15	complexes	complex	NNS
cord-010604-3d37o05y	30	16	,	,	,
cord-010604-3d37o05y	30	17	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	30	18	was	be	VBD
cord-010604-3d37o05y	30	19	shown	show	VBN
cord-010604-3d37o05y	30	20	to	to	TO
cord-010604-3d37o05y	30	21	be	be	VB
cord-010604-3d37o05y	30	22	a	a	DT
cord-010604-3d37o05y	30	23	potent	potent	JJ
cord-010604-3d37o05y	30	24	inhibitor	inhibitor	NN
cord-010604-3d37o05y	30	25	of	of	IN
cord-010604-3d37o05y	30	26	GR	GR	NNP
cord-010604-3d37o05y	30	27	by	by	IN
cord-010604-3d37o05y	30	28	several	several	JJ
cord-010604-3d37o05y	30	29	laboratories	laboratory	NNS
cord-010604-3d37o05y	30	30	[	[	-LRB-
cord-010604-3d37o05y	30	31	16	16	CD
cord-010604-3d37o05y	30	32	]	]	-RRB-
cord-010604-3d37o05y	31	1	[	[	-LRB-
cord-010604-3d37o05y	31	2	17	17	CD
cord-010604-3d37o05y	31	3	]	]	-RRB-
cord-010604-3d37o05y	31	4	[	[	-LRB-
cord-010604-3d37o05y	31	5	18	18	CD
cord-010604-3d37o05y	31	6	]	]	-RRB-
cord-010604-3d37o05y	31	7	[	[	-LRB-
cord-010604-3d37o05y	31	8	19	19	CD
cord-010604-3d37o05y	31	9	]	]	-RRB-
cord-010604-3d37o05y	31	10	.	.	.
cord-010604-3d37o05y	32	1	By	by	IN
cord-010604-3d37o05y	32	2	virtue	virtue	NN
cord-010604-3d37o05y	32	3	of	of	IN
cord-010604-3d37o05y	32	4	its	-PRON-	PRP$
cord-010604-3d37o05y	32	5	binding	binding	NN
cord-010604-3d37o05y	32	6	to	to	IN
cord-010604-3d37o05y	32	7	immune	immune	JJ
cord-010604-3d37o05y	32	8	suppressive	suppressive	JJ
cord-010604-3d37o05y	32	9	drugs	drug	NNS
cord-010604-3d37o05y	32	10	such	such	JJ
cord-010604-3d37o05y	32	11	as	as	IN
cord-010604-3d37o05y	32	12	FK506	FK506	NNP
cord-010604-3d37o05y	32	13	,	,	,
cord-010604-3d37o05y	32	14	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	32	15	also	also	RB
cord-010604-3d37o05y	32	16	has	have	VBZ
cord-010604-3d37o05y	32	17	been	be	VBN
cord-010604-3d37o05y	32	18	classified	classify	VBN
cord-010604-3d37o05y	32	19	as	as	IN
cord-010604-3d37o05y	32	20	'	'	``
cord-010604-3d37o05y	32	21	immunophilin	immunophilin	NNP
cord-010604-3d37o05y	32	22	'	'	''
cord-010604-3d37o05y	32	23	[	[	-LRB-
cord-010604-3d37o05y	32	24	15	15	CD
cord-010604-3d37o05y	32	25	]	]	-RRB-
cord-010604-3d37o05y	32	26	.	.	.
cord-010604-3d37o05y	33	1	Biochemically	biochemically	RB
cord-010604-3d37o05y	33	2	,	,	,
cord-010604-3d37o05y	33	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	33	4	is	be	VBZ
cord-010604-3d37o05y	33	5	able	able	JJ
cord-010604-3d37o05y	33	6	to	to	TO
cord-010604-3d37o05y	33	7	isomerize	isomerize	VB
cord-010604-3d37o05y	33	8	peptidyl	peptidyl	JJ
cord-010604-3d37o05y	33	9	-	-	HYPH
cord-010604-3d37o05y	33	10	prolyl	prolyl	JJ
cord-010604-3d37o05y	33	11	bonds	bond	NNS
cord-010604-3d37o05y	33	12	[	[	-LRB-
cord-010604-3d37o05y	33	13	20	20	CD
cord-010604-3d37o05y	33	14	]	]	-RRB-
cord-010604-3d37o05y	33	15	;	;	:
cord-010604-3d37o05y	33	16	the	the	DT
cord-010604-3d37o05y	33	17	physiological	physiological	JJ
cord-010604-3d37o05y	33	18	relevance	relevance	NN
cord-010604-3d37o05y	33	19	,	,	,
cord-010604-3d37o05y	33	20	if	if	IN
cord-010604-3d37o05y	33	21	any	any	DT
cord-010604-3d37o05y	33	22	,	,	,
cord-010604-3d37o05y	33	23	of	of	IN
cord-010604-3d37o05y	33	24	this	this	DT
cord-010604-3d37o05y	33	25	function	function	NN
cord-010604-3d37o05y	33	26	is	be	VBZ
cord-010604-3d37o05y	33	27	not	not	RB
cord-010604-3d37o05y	33	28	clear	clear	JJ
cord-010604-3d37o05y	33	29	[	[	-LRB-
cord-010604-3d37o05y	33	30	11	11	CD
cord-010604-3d37o05y	33	31	,	,	,
cord-010604-3d37o05y	33	32	12	12	CD
cord-010604-3d37o05y	33	33	,	,	,
cord-010604-3d37o05y	33	34	21	21	CD
cord-010604-3d37o05y	33	35	]	]	-RRB-
cord-010604-3d37o05y	33	36	.	.	.
cord-010604-3d37o05y	34	1	However	however	RB
cord-010604-3d37o05y	34	2	,	,	,
cord-010604-3d37o05y	34	3	the	the	DT
cord-010604-3d37o05y	34	4	peptidylprolyl	peptidylprolyl	JJ
cord-010604-3d37o05y	34	5	isomerase	isomerase	NN
cord-010604-3d37o05y	34	6	domain	domain	NN
cord-010604-3d37o05y	34	7	of	of	IN
cord-010604-3d37o05y	34	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	34	9	is	be	VBZ
cord-010604-3d37o05y	34	10	engaged	engage	VBN
cord-010604-3d37o05y	34	11	in	in	IN
cord-010604-3d37o05y	34	12	protein	protein	NN
cord-010604-3d37o05y	34	13	interactions	interaction	NNS
cord-010604-3d37o05y	34	14	,	,	,
cord-010604-3d37o05y	34	15	and	and	CC
cord-010604-3d37o05y	34	16	drug	drug	NN
cord-010604-3d37o05y	34	17	binding	bind	VBG
cord-010604-3d37o05y	34	18	to	to	IN
cord-010604-3d37o05y	34	19	this	this	DT
cord-010604-3d37o05y	34	20	domain	domain	NN
cord-010604-3d37o05y	34	21	likely	likely	RB
cord-010604-3d37o05y	34	22	affects	affect	VBZ
cord-010604-3d37o05y	34	23	several	several	JJ
cord-010604-3d37o05y	34	24	functions	function	NNS
cord-010604-3d37o05y	34	25	of	of	IN
cord-010604-3d37o05y	34	26	this	this	DT
cord-010604-3d37o05y	34	27	protein	protein	NN
cord-010604-3d37o05y	34	28	[	[	-LRB-
cord-010604-3d37o05y	34	29	13	13	CD
cord-010604-3d37o05y	34	30	]	]	-RRB-
cord-010604-3d37o05y	34	31	.	.	.
cord-010604-3d37o05y	35	1	The	the	DT
cord-010604-3d37o05y	35	2	inducibility	inducibility	NN
cord-010604-3d37o05y	35	3	of	of	IN
cord-010604-3d37o05y	35	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	35	5	gene	gene	NN
cord-010604-3d37o05y	35	6	(	(	-LRB-
cord-010604-3d37o05y	35	7	named	name	VBN
cord-010604-3d37o05y	35	8	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	35	9	)	)	-RRB-
cord-010604-3d37o05y	35	10	expression	expression	NN
cord-010604-3d37o05y	35	11	by	by	IN
cord-010604-3d37o05y	35	12	the	the	DT
cord-010604-3d37o05y	35	13	activated	activate	VBN
cord-010604-3d37o05y	35	14	GR	GR	NNP
cord-010604-3d37o05y	35	15	[	[	-LRB-
cord-010604-3d37o05y	35	16	22	22	CD
cord-010604-3d37o05y	35	17	]	]	-RRB-
cord-010604-3d37o05y	35	18	[	[	-LRB-
cord-010604-3d37o05y	35	19	23	23	CD
cord-010604-3d37o05y	35	20	]	]	-RRB-
cord-010604-3d37o05y	35	21	[	[	-LRB-
cord-010604-3d37o05y	35	22	24	24	CD
cord-010604-3d37o05y	35	23	]	]	-RRB-
cord-010604-3d37o05y	35	24	[	[	-LRB-
cord-010604-3d37o05y	35	25	25	25	CD
cord-010604-3d37o05y	35	26	]	]	-RRB-
cord-010604-3d37o05y	35	27	[	[	-LRB-
cord-010604-3d37o05y	35	28	26	26	CD
cord-010604-3d37o05y	35	29	]	]	-RRB-
cord-010604-3d37o05y	35	30	[	[	-LRB-
cord-010604-3d37o05y	35	31	27	27	CD
cord-010604-3d37o05y	35	32	]	]	-RRB-
cord-010604-3d37o05y	35	33	gives	give	VBZ
cord-010604-3d37o05y	35	34	rise	rise	NN
cord-010604-3d37o05y	35	35	to	to	IN
cord-010604-3d37o05y	35	36	an	an	DT
cord-010604-3d37o05y	35	37	intracellular	intracellular	JJ
cord-010604-3d37o05y	35	38	ultra	ultra	JJ
cord-010604-3d37o05y	35	39	-	-	JJ
cord-010604-3d37o05y	35	40	short	short	JJ
cord-010604-3d37o05y	35	41	negative	negative	JJ
cord-010604-3d37o05y	35	42	feedback	feedback	NN
cord-010604-3d37o05y	35	43	loop	loop	NN
cord-010604-3d37o05y	35	44	,	,	,
cord-010604-3d37o05y	35	45	as	as	IN
cord-010604-3d37o05y	35	46	one	one	CD
cord-010604-3d37o05y	35	47	of	of	IN
cord-010604-3d37o05y	35	48	the	the	DT
cord-010604-3d37o05y	35	49	hallmarks	hallmark	NNS
cord-010604-3d37o05y	35	50	of	of	IN
cord-010604-3d37o05y	35	51	adaptive	adaptive	JJ
cord-010604-3d37o05y	35	52	molecular	molecular	JJ
cord-010604-3d37o05y	35	53	circuits	circuit	NNS
cord-010604-3d37o05y	35	54	[	[	-LRB-
cord-010604-3d37o05y	35	55	11	11	CD
cord-010604-3d37o05y	35	56	]	]	-RRB-
cord-010604-3d37o05y	35	57	.	.	.
cord-010604-3d37o05y	36	1	Of	of	IN
cord-010604-3d37o05y	36	2	particular	particular	JJ
cord-010604-3d37o05y	36	3	interest	interest	NN
cord-010604-3d37o05y	36	4	for	for	IN
cord-010604-3d37o05y	36	5	neuropsychiatric	neuropsychiatric	JJ
cord-010604-3d37o05y	36	6	research	research	NN
cord-010604-3d37o05y	36	7	was	be	VBD
cord-010604-3d37o05y	36	8	the	the	DT
cord-010604-3d37o05y	36	9	observation	observation	NN
cord-010604-3d37o05y	36	10	that	that	IN
cord-010604-3d37o05y	36	11	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	36	12	was	be	VBD
cord-010604-3d37o05y	36	13	overexpressed	overexpresse	VBN
cord-010604-3d37o05y	36	14	in	in	IN
cord-010604-3d37o05y	36	15	squirrel	squirrel	NN
cord-010604-3d37o05y	36	16	monkeys	monkey	NNS
cord-010604-3d37o05y	36	17	featuring	feature	VBG
cord-010604-3d37o05y	36	18	altered	alter	VBN
cord-010604-3d37o05y	36	19	set	set	NN
cord-010604-3d37o05y	36	20	-	-	HYPH
cord-010604-3d37o05y	36	21	points	point	NNS
cord-010604-3d37o05y	36	22	of	of	IN
cord-010604-3d37o05y	36	23	the	the	DT
cord-010604-3d37o05y	36	24	HPA	HPA	NNP
cord-010604-3d37o05y	36	25	axis	axis	NN
cord-010604-3d37o05y	36	26	[	[	-LRB-
cord-010604-3d37o05y	36	27	28	28	CD
cord-010604-3d37o05y	36	28	]	]	-RRB-
cord-010604-3d37o05y	36	29	.	.	.
cord-010604-3d37o05y	37	1	Thus	thus	RB
cord-010604-3d37o05y	37	2	,	,	,
cord-010604-3d37o05y	37	3	the	the	DT
cord-010604-3d37o05y	37	4	molecular	molecular	JJ
cord-010604-3d37o05y	37	5	settings	setting	NNS
cord-010604-3d37o05y	37	6	in	in	IN
cord-010604-3d37o05y	37	7	these	these	DT
cord-010604-3d37o05y	37	8	animals	animal	NNS
cord-010604-3d37o05y	37	9	were	be	VBD
cord-010604-3d37o05y	37	10	considered	consider	VBN
cord-010604-3d37o05y	37	11	a	a	DT
cord-010604-3d37o05y	37	12	model	model	NN
cord-010604-3d37o05y	37	13	for	for	IN
cord-010604-3d37o05y	37	14	GR	GR	NNP
cord-010604-3d37o05y	37	15	-	-	HYPH
cord-010604-3d37o05y	37	16	resistance	resistance	NN
cord-010604-3d37o05y	37	17	[	[	-LRB-
cord-010604-3d37o05y	37	18	29	29	CD
cord-010604-3d37o05y	37	19	]	]	-RRB-
cord-010604-3d37o05y	37	20	.	.	.
cord-010604-3d37o05y	38	1	This	this	DT
cord-010604-3d37o05y	38	2	was	be	VBD
cord-010604-3d37o05y	38	3	related	relate	VBN
cord-010604-3d37o05y	38	4	to	to	IN
cord-010604-3d37o05y	38	5	the	the	DT
cord-010604-3d37o05y	38	6	situation	situation	NN
cord-010604-3d37o05y	38	7	in	in	IN
cord-010604-3d37o05y	38	8	patients	patient	NNS
cord-010604-3d37o05y	38	9	suffering	suffer	VBG
cord-010604-3d37o05y	38	10	from	from	IN
cord-010604-3d37o05y	38	11	depression	depression	NN
cord-010604-3d37o05y	38	12	where	where	WRB
cord-010604-3d37o05y	38	13	malfunction	malfunction	NN
cord-010604-3d37o05y	38	14	of	of	IN
cord-010604-3d37o05y	38	15	GR	GR	NNP
cord-010604-3d37o05y	38	16	was	be	VBD
cord-010604-3d37o05y	38	17	hypothesized	hypothesize	VBN
cord-010604-3d37o05y	38	18	to	to	TO
cord-010604-3d37o05y	38	19	be	be	VB
cord-010604-3d37o05y	38	20	causal	causal	JJ
cord-010604-3d37o05y	38	21	for	for	IN
cord-010604-3d37o05y	38	22	the	the	DT
cord-010604-3d37o05y	38	23	development	development	NN
cord-010604-3d37o05y	38	24	of	of	IN
cord-010604-3d37o05y	38	25	the	the	DT
cord-010604-3d37o05y	38	26	disease	disease	NN
cord-010604-3d37o05y	38	27	[	[	-LRB-
cord-010604-3d37o05y	38	28	30	30	CD
cord-010604-3d37o05y	38	29	]	]	-RRB-
cord-010604-3d37o05y	38	30	.	.	.
cord-010604-3d37o05y	39	1	Based	base	VBN
cord-010604-3d37o05y	39	2	on	on	IN
cord-010604-3d37o05y	39	3	these	these	DT
cord-010604-3d37o05y	39	4	considerations	consideration	NNS
cord-010604-3d37o05y	39	5	,	,	,
cord-010604-3d37o05y	39	6	FKBP5	FKBP5	NNPS
cord-010604-3d37o05y	39	7	was	be	VBD
cord-010604-3d37o05y	39	8	included	include	VBN
cord-010604-3d37o05y	39	9	as	as	IN
cord-010604-3d37o05y	39	10	candidate	candidate	NN
cord-010604-3d37o05y	39	11	gene	gene	NN
cord-010604-3d37o05y	39	12	in	in	IN
cord-010604-3d37o05y	39	13	an	an	DT
cord-010604-3d37o05y	39	14	early	early	JJ
cord-010604-3d37o05y	39	15	gene	gene	NN
cord-010604-3d37o05y	39	16	association	association	NN
cord-010604-3d37o05y	39	17	study	study	NN
cord-010604-3d37o05y	39	18	in	in	IN
cord-010604-3d37o05y	39	19	depression	depression	NN
cord-010604-3d37o05y	39	20	that	that	WDT
cord-010604-3d37o05y	39	21	found	find	VBD
cord-010604-3d37o05y	39	22	this	this	DT
cord-010604-3d37o05y	39	23	gene	gene	NN
cord-010604-3d37o05y	39	24	linked	link	VBN
cord-010604-3d37o05y	39	25	to	to	IN
cord-010604-3d37o05y	39	26	the	the	DT
cord-010604-3d37o05y	39	27	response	response	NN
cord-010604-3d37o05y	39	28	to	to	IN
cord-010604-3d37o05y	39	29	antidepressant	antidepressant	JJ
cord-010604-3d37o05y	39	30	treatment	treatment	NN
cord-010604-3d37o05y	39	31	[	[	-LRB-
cord-010604-3d37o05y	39	32	31	31	CD
cord-010604-3d37o05y	39	33	]	]	-RRB-
cord-010604-3d37o05y	39	34	.	.	.
cord-010604-3d37o05y	40	1	Later	later	RB
cord-010604-3d37o05y	40	2	,	,	,
cord-010604-3d37o05y	40	3	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	40	4	could	could	MD
cord-010604-3d37o05y	40	5	be	be	VB
cord-010604-3d37o05y	40	6	linked	link	VBN
cord-010604-3d37o05y	40	7	to	to	IN
cord-010604-3d37o05y	40	8	additional	additional	JJ
cord-010604-3d37o05y	40	9	stress	stress	NN
cord-010604-3d37o05y	40	10	-	-	HYPH
cord-010604-3d37o05y	40	11	related	relate	VBN
cord-010604-3d37o05y	40	12	diseases	disease	NNS
cord-010604-3d37o05y	40	13	such	such	JJ
cord-010604-3d37o05y	40	14	as	as	IN
cord-010604-3d37o05y	40	15	post	post	JJ
cord-010604-3d37o05y	40	16	-	-	JJ
cord-010604-3d37o05y	40	17	traumatic	traumatic	JJ
cord-010604-3d37o05y	40	18	stress	stress	NN
cord-010604-3d37o05y	40	19	disorder	disorder	NN
cord-010604-3d37o05y	40	20	[	[	-LRB-
cord-010604-3d37o05y	40	21	12	12	CD
cord-010604-3d37o05y	40	22	,	,	,
cord-010604-3d37o05y	40	23	14	14	CD
cord-010604-3d37o05y	40	24	]	]	-RRB-
cord-010604-3d37o05y	40	25	.	.	.
cord-010604-3d37o05y	41	1	These	these	DT
cord-010604-3d37o05y	41	2	findings	finding	NNS
cord-010604-3d37o05y	41	3	strongly	strongly	RB
cord-010604-3d37o05y	41	4	amplified	amplify	VBD
cord-010604-3d37o05y	41	5	the	the	DT
cord-010604-3d37o05y	41	6	interest	interest	NN
cord-010604-3d37o05y	41	7	in	in	IN
cord-010604-3d37o05y	41	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	41	9	and	and	CC
cord-010604-3d37o05y	41	10	stimulated	stimulate	VBD
cord-010604-3d37o05y	41	11	research	research	NN
cord-010604-3d37o05y	41	12	on	on	IN
cord-010604-3d37o05y	41	13	its	-PRON-	PRP$
cord-010604-3d37o05y	41	14	function	function	NN
cord-010604-3d37o05y	41	15	and	and	CC
cord-010604-3d37o05y	41	16	regulation	regulation	NN
cord-010604-3d37o05y	41	17	in	in	IN
cord-010604-3d37o05y	41	18	several	several	JJ
cord-010604-3d37o05y	41	19	laboratories	laboratory	NNS
cord-010604-3d37o05y	41	20	;	;	:
cord-010604-3d37o05y	41	21	this	this	DT
cord-010604-3d37o05y	41	22	greatly	greatly	RB
cord-010604-3d37o05y	41	23	expanded	expand	VBD
cord-010604-3d37o05y	41	24	the	the	DT
cord-010604-3d37o05y	41	25	knowledge	knowledge	NN
cord-010604-3d37o05y	41	26	base	base	NN
cord-010604-3d37o05y	41	27	on	on	IN
cord-010604-3d37o05y	41	28	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	41	29	's	's	POS
cord-010604-3d37o05y	41	30	(	(	-LRB-
cord-010604-3d37o05y	41	31	patho)physiological	patho)physiological	NNP
cord-010604-3d37o05y	41	32	role	role	NN
cord-010604-3d37o05y	41	33	,	,	,
cord-010604-3d37o05y	41	34	regulation	regulation	NN
cord-010604-3d37o05y	41	35	on	on	IN
cord-010604-3d37o05y	41	36	several	several	JJ
cord-010604-3d37o05y	41	37	levels	level	NNS
cord-010604-3d37o05y	41	38	and	and	CC
cord-010604-3d37o05y	41	39	involvement	involvement	NN
cord-010604-3d37o05y	41	40	in	in	IN
cord-010604-3d37o05y	41	41	multiple	multiple	JJ
cord-010604-3d37o05y	41	42	molecular	molecular	JJ
cord-010604-3d37o05y	41	43	pathways	pathway	NNS
cord-010604-3d37o05y	41	44	,	,	,
cord-010604-3d37o05y	41	45	going	go	VBG
cord-010604-3d37o05y	41	46	beyond	beyond	IN
cord-010604-3d37o05y	41	47	stress	stress	NN
cord-010604-3d37o05y	41	48	regulation	regulation	NN
cord-010604-3d37o05y	41	49	[	[	-LRB-
cord-010604-3d37o05y	41	50	12	12	CD
cord-010604-3d37o05y	41	51	,	,	,
cord-010604-3d37o05y	41	52	13	13	CD
cord-010604-3d37o05y	41	53	]	]	-RRB-
cord-010604-3d37o05y	41	54	.	.	.
cord-010604-3d37o05y	42	1	The	the	DT
cord-010604-3d37o05y	42	2	variety	variety	NN
cord-010604-3d37o05y	42	3	of	of	IN
cord-010604-3d37o05y	42	4	its	-PRON-	PRP$
cord-010604-3d37o05y	42	5	physiological	physiological	JJ
cord-010604-3d37o05y	42	6	functions	function	NNS
cord-010604-3d37o05y	42	7	goes	go	VBZ
cord-010604-3d37o05y	42	8	along	along	RB
cord-010604-3d37o05y	42	9	with	with	IN
cord-010604-3d37o05y	42	10	its	-PRON-	PRP$
cord-010604-3d37o05y	42	11	association	association	NN
cord-010604-3d37o05y	42	12	with	with	IN
cord-010604-3d37o05y	42	13	several	several	JJ
cord-010604-3d37o05y	42	14	proteins	protein	NNS
cord-010604-3d37o05y	42	15	,	,	,
cord-010604-3d37o05y	42	16	including	include	VBG
cord-010604-3d37o05y	42	17	proteins	protein	NNS
cord-010604-3d37o05y	42	18	involved	involve	VBN
cord-010604-3d37o05y	42	19	in	in	IN
cord-010604-3d37o05y	42	20	writing	write	VBG
cord-010604-3d37o05y	42	21	and	and	CC
cord-010604-3d37o05y	42	22	erasing	erase	VBG
cord-010604-3d37o05y	42	23	PTMs	ptm	NNS
cord-010604-3d37o05y	42	24	,	,	,
cord-010604-3d37o05y	42	25	as	as	IN
cord-010604-3d37o05y	42	26	detailed	detail	VBN
cord-010604-3d37o05y	42	27	in	in	IN
cord-010604-3d37o05y	42	28	the	the	DT
cord-010604-3d37o05y	42	29	subsequent	subsequent	JJ
cord-010604-3d37o05y	42	30	sections	section	NNS
cord-010604-3d37o05y	42	31	.	.	.
cord-010604-3d37o05y	43	1	More	More	JJR
cord-010604-3d37o05y	43	2	than	than	IN
cord-010604-3d37o05y	43	3	200	200	CD
cord-010604-3d37o05y	43	4	PTMs	ptm	NNS
cord-010604-3d37o05y	43	5	are	be	VBP
cord-010604-3d37o05y	43	6	known	know	VBN
cord-010604-3d37o05y	43	7	with	with	IN
cord-010604-3d37o05y	43	8	a	a	DT
cord-010604-3d37o05y	43	9	major	major	JJ
cord-010604-3d37o05y	43	10	impact	impact	NN
cord-010604-3d37o05y	43	11	in	in	IN
cord-010604-3d37o05y	43	12	the	the	DT
cord-010604-3d37o05y	43	13	configuration	configuration	NN
cord-010604-3d37o05y	43	14	of	of	IN
cord-010604-3d37o05y	43	15	protein	protein	NN
cord-010604-3d37o05y	43	16	networks	network	NNS
cord-010604-3d37o05y	43	17	[	[	-LRB-
cord-010604-3d37o05y	43	18	32	32	CD
cord-010604-3d37o05y	43	19	]	]	-RRB-
cord-010604-3d37o05y	43	20	[	[	-LRB-
cord-010604-3d37o05y	43	21	33	33	CD
cord-010604-3d37o05y	43	22	]	]	-RRB-
cord-010604-3d37o05y	43	23	[	[	-LRB-
cord-010604-3d37o05y	43	24	34	34	CD
cord-010604-3d37o05y	43	25	]	]	-RRB-
cord-010604-3d37o05y	43	26	;	;	:
cord-010604-3d37o05y	43	27	the	the	DT
cord-010604-3d37o05y	43	28	vast	vast	JJ
cord-010604-3d37o05y	43	29	majority	majority	NN
cord-010604-3d37o05y	43	30	of	of	IN
cord-010604-3d37o05y	43	31	these	these	DT
cord-010604-3d37o05y	43	32	modifications	modification	NNS
cord-010604-3d37o05y	43	33	are	be	VBP
cord-010604-3d37o05y	43	34	reversible	reversible	JJ
cord-010604-3d37o05y	43	35	with	with	IN
cord-010604-3d37o05y	43	36	prominent	prominent	JJ
cord-010604-3d37o05y	43	37	examples	example	NNS
cord-010604-3d37o05y	43	38	being	be	VBG
cord-010604-3d37o05y	43	39	the	the	DT
cord-010604-3d37o05y	43	40	attachment	attachment	NN
cord-010604-3d37o05y	43	41	of	of	IN
cord-010604-3d37o05y	43	42	chemical	chemical	JJ
cord-010604-3d37o05y	43	43	groups	group	NNS
cord-010604-3d37o05y	43	44	(	(	-LRB-
cord-010604-3d37o05y	43	45	e.g.	e.g.	JJ
cord-010604-3d37o05y	43	46	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	43	47	,	,	,
cord-010604-3d37o05y	43	48	acetylation	acetylation	NN
cord-010604-3d37o05y	43	49	,	,	,
cord-010604-3d37o05y	43	50	methylation	methylation	NN
cord-010604-3d37o05y	43	51	,	,	,
cord-010604-3d37o05y	43	52	nitrosylation	nitrosylation	NN
cord-010604-3d37o05y	43	53	,	,	,
cord-010604-3d37o05y	43	54	sulfonation	sulfonation	NN
cord-010604-3d37o05y	43	55	)	)	-RRB-
cord-010604-3d37o05y	43	56	,	,	,
cord-010604-3d37o05y	43	57	the	the	DT
cord-010604-3d37o05y	43	58	conjugation	conjugation	NN
cord-010604-3d37o05y	43	59	with	with	IN
cord-010604-3d37o05y	43	60	polypeptides	polypeptide	NNS
cord-010604-3d37o05y	43	61	(	(	-LRB-
cord-010604-3d37o05y	43	62	e.g.	e.g.	RB
cord-010604-3d37o05y	43	63	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	43	64	,	,	,
cord-010604-3d37o05y	43	65	NEDD8	NEDD8	NNP
cord-010604-3d37o05y	44	1	[	[	-LRB-
cord-010604-3d37o05y	44	2	neural	neural	JJ
cord-010604-3d37o05y	44	3	-	-	HYPH
cord-010604-3d37o05y	44	4	precursor	precursor	NN
cord-010604-3d37o05y	44	5	-	-	HYPH
cord-010604-3d37o05y	44	6	cell	cell	NN
cord-010604-3d37o05y	44	7	-	-	HYPH
cord-010604-3d37o05y	44	8	expressed	express	VBN
cord-010604-3d37o05y	44	9	developmentally	developmentally	RB
cord-010604-3d37o05y	44	10	down	down	RB
cord-010604-3d37o05y	44	11	-	-	HYPH
cord-010604-3d37o05y	44	12	regulated	regulate	VBN
cord-010604-3d37o05y	44	13	8	8	CD
cord-010604-3d37o05y	44	14	]	]	-RRB-
cord-010604-3d37o05y	44	15	,	,	,
cord-010604-3d37o05y	44	16	and	and	CC
cord-010604-3d37o05y	44	17	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	44	18	-	-	HYPH
cord-010604-3d37o05y	44	19	like	like	JJ
cord-010604-3d37o05y	44	20	peptides	peptide	NNS
cord-010604-3d37o05y	44	21	such	such	JJ
cord-010604-3d37o05y	44	22	as	as	IN
cord-010604-3d37o05y	44	23	SUMO	SUMO	NNP
cord-010604-3d37o05y	44	24	[	[	-LRB-
cord-010604-3d37o05y	44	25	small	small	JJ
cord-010604-3d37o05y	44	26	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	44	27	-	-	HYPH
cord-010604-3d37o05y	44	28	like	like	JJ
cord-010604-3d37o05y	44	29	modifier	modifier	NN
cord-010604-3d37o05y	44	30	]	]	-RRB-
cord-010604-3d37o05y	44	31	or	or	CC
cord-010604-3d37o05y	44	32	ATG8	ATG8	NNP
cord-010604-3d37o05y	44	33	[	[	-LRB-
cord-010604-3d37o05y	44	34	autophagy	autophagy	NN
cord-010604-3d37o05y	44	35	-	-	HYPH
cord-010604-3d37o05y	44	36	related	relate	VBN
cord-010604-3d37o05y	44	37	gene	gene	NN
cord-010604-3d37o05y	44	38	8	8	CD
cord-010604-3d37o05y	44	39	]	]	-RRB-
cord-010604-3d37o05y	44	40	)	)	-RRB-
cord-010604-3d37o05y	44	41	and	and	CC
cord-010604-3d37o05y	44	42	the	the	DT
cord-010604-3d37o05y	44	43	addition	addition	NN
cord-010604-3d37o05y	44	44	of	of	IN
cord-010604-3d37o05y	44	45	a	a	DT
cord-010604-3d37o05y	44	46	complex	complex	JJ
cord-010604-3d37o05y	44	47	group	group	NN
cord-010604-3d37o05y	44	48	of	of	IN
cord-010604-3d37o05y	44	49	molecules	molecule	NNS
cord-010604-3d37o05y	44	50	including	include	VBG
cord-010604-3d37o05y	44	51	,	,	,
cord-010604-3d37o05y	44	52	e.g.	e.g.	RB
cord-010604-3d37o05y	44	53	prenylation	prenylation	NN
cord-010604-3d37o05y	44	54	,	,	,
cord-010604-3d37o05y	44	55	farnesylation	farnesylation	NN
cord-010604-3d37o05y	44	56	,	,	,
cord-010604-3d37o05y	44	57	glycosylation	glycosylation	NN
cord-010604-3d37o05y	44	58	,	,	,
cord-010604-3d37o05y	44	59	palmitoylation	palmitoylation	NN
cord-010604-3d37o05y	44	60	,	,	,
cord-010604-3d37o05y	44	61	myristoylation	myristoylation	NN
cord-010604-3d37o05y	44	62	,	,	,
cord-010604-3d37o05y	44	63	glutamylation	glutamylation	NN
cord-010604-3d37o05y	44	64	,	,	,
cord-010604-3d37o05y	44	65	ADP	ADP	NNP
cord-010604-3d37o05y	44	66	-	-	HYPH
cord-010604-3d37o05y	44	67	ribosylation	ribosylation	NN
cord-010604-3d37o05y	44	68	and	and	CC
cord-010604-3d37o05y	44	69	AMPylation	ampylation	NN
cord-010604-3d37o05y	44	70	[	[	-LRB-
cord-010604-3d37o05y	44	71	4	4	CD
cord-010604-3d37o05y	44	72	,	,	,
cord-010604-3d37o05y	44	73	35	35	CD
cord-010604-3d37o05y	44	74	]	]	-RRB-
cord-010604-3d37o05y	44	75	.	.	.
cord-010604-3d37o05y	45	1	Protein	protein	NN
cord-010604-3d37o05y	45	2	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	45	3	is	be	VBZ
cord-010604-3d37o05y	45	4	one	one	CD
cord-010604-3d37o05y	45	5	of	of	IN
cord-010604-3d37o05y	45	6	the	the	DT
cord-010604-3d37o05y	45	7	first	first	RB
cord-010604-3d37o05y	45	8	known	know	VBN
cord-010604-3d37o05y	45	9	PTM	PTM	NNP
cord-010604-3d37o05y	45	10	[	[	-LRB-
cord-010604-3d37o05y	45	11	36	36	CD
cord-010604-3d37o05y	45	12	,	,	,
cord-010604-3d37o05y	45	13	37	37	CD
cord-010604-3d37o05y	45	14	]	]	-RRB-
cord-010604-3d37o05y	45	15	and	and	CC
cord-010604-3d37o05y	45	16	probably	probably	RB
cord-010604-3d37o05y	45	17	the	the	DT
cord-010604-3d37o05y	45	18	best	well	RBS
cord-010604-3d37o05y	45	19	studied	study	VBD
cord-010604-3d37o05y	45	20	one	one	CD
cord-010604-3d37o05y	45	21	affecting	affect	VBG
cord-010604-3d37o05y	45	22	almost	almost	RB
cord-010604-3d37o05y	45	23	all	all	DT
cord-010604-3d37o05y	45	24	biological	biological	JJ
cord-010604-3d37o05y	45	25	processes	process	NNS
cord-010604-3d37o05y	45	26	[	[	-LRB-
cord-010604-3d37o05y	45	27	38	38	CD
cord-010604-3d37o05y	45	28	]	]	-RRB-
cord-010604-3d37o05y	45	29	.	.	.
cord-010604-3d37o05y	46	1	In	in	IN
cord-010604-3d37o05y	46	2	eukaryotes	eukaryote	NNS
cord-010604-3d37o05y	46	3	,	,	,
cord-010604-3d37o05y	46	4	proteins	protein	NNS
cord-010604-3d37o05y	46	5	are	be	VBP
cord-010604-3d37o05y	46	6	phosphorylated	phosphorylate	VBN
cord-010604-3d37o05y	46	7	primarily	primarily	RB
cord-010604-3d37o05y	46	8	through	through	IN
cord-010604-3d37o05y	46	9	phosphor	phosphor	NN
cord-010604-3d37o05y	46	10	-	-	HYPH
cord-010604-3d37o05y	46	11	ester	ester	NN
cord-010604-3d37o05y	46	12	bonds	bond	NNS
cord-010604-3d37o05y	46	13	formed	form	VBN
cord-010604-3d37o05y	46	14	at	at	IN
cord-010604-3d37o05y	46	15	the	the	DT
cord-010604-3d37o05y	46	16	residues	residue	NNS
cord-010604-3d37o05y	46	17	serine	serine	NN
cord-010604-3d37o05y	46	18	,	,	,
cord-010604-3d37o05y	46	19	threonine	threonine	NN
cord-010604-3d37o05y	46	20	and	and	CC
cord-010604-3d37o05y	46	21	tyrosine	tyrosine	NN
cord-010604-3d37o05y	46	22	,	,	,
cord-010604-3d37o05y	46	23	and	and	CC
cord-010604-3d37o05y	46	24	up	up	IN
cord-010604-3d37o05y	46	25	to	to	TO
cord-010604-3d37o05y	46	26	2	2	CD
cord-010604-3d37o05y	46	27	%	%	NN
cord-010604-3d37o05y	46	28	of	of	IN
cord-010604-3d37o05y	46	29	the	the	DT
cord-010604-3d37o05y	46	30	protein	protein	NN
cord-010604-3d37o05y	46	31	-	-	HYPH
cord-010604-3d37o05y	46	32	coding	code	VBG
cord-010604-3d37o05y	46	33	genes	gene	NNS
cord-010604-3d37o05y	46	34	produce	produce	VBP
cord-010604-3d37o05y	46	35	the	the	DT
cord-010604-3d37o05y	46	36	enzymatic	enzymatic	JJ
cord-010604-3d37o05y	46	37	machinery	machinery	NN
cord-010604-3d37o05y	46	38	governing	govern	VBG
cord-010604-3d37o05y	46	39	this	this	DT
cord-010604-3d37o05y	46	40	process	process	NN
cord-010604-3d37o05y	46	41	[	[	-LRB-
cord-010604-3d37o05y	46	42	39	39	CD
cord-010604-3d37o05y	46	43	]	]	-RRB-
cord-010604-3d37o05y	46	44	.	.	.
cord-010604-3d37o05y	47	1	While	while	IN
cord-010604-3d37o05y	47	2	this	this	DT
cord-010604-3d37o05y	47	3	review	review	NN
cord-010604-3d37o05y	47	4	focusses	focusse	VBZ
cord-010604-3d37o05y	47	5	on	on	IN
cord-010604-3d37o05y	47	6	the	the	DT
cord-010604-3d37o05y	47	7	effect	effect	NN
cord-010604-3d37o05y	47	8	of	of	IN
cord-010604-3d37o05y	47	9	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	47	10	on	on	IN
cord-010604-3d37o05y	47	11	PTMs	ptm	NNS
cord-010604-3d37o05y	47	12	of	of	IN
cord-010604-3d37o05y	47	13	other	other	JJ
cord-010604-3d37o05y	47	14	proteins	protein	NNS
cord-010604-3d37o05y	47	15	,	,	,
cord-010604-3d37o05y	47	16	it	-PRON-	PRP
cord-010604-3d37o05y	47	17	should	should	MD
cord-010604-3d37o05y	47	18	be	be	VB
cord-010604-3d37o05y	47	19	noted	note	VBN
cord-010604-3d37o05y	47	20	that	that	IN
cord-010604-3d37o05y	47	21	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	47	22	also	also	RB
cord-010604-3d37o05y	47	23	is	be	VBZ
cord-010604-3d37o05y	47	24	subject	subject	JJ
cord-010604-3d37o05y	47	25	to	to	IN
cord-010604-3d37o05y	47	26	PTMs	ptm	NNS
cord-010604-3d37o05y	47	27	itself	-PRON-	PRP
cord-010604-3d37o05y	47	28	.	.	.
cord-010604-3d37o05y	48	1	This	this	DT
cord-010604-3d37o05y	48	2	has	have	VBZ
cord-010604-3d37o05y	48	3	been	be	VBN
cord-010604-3d37o05y	48	4	reviewed	review	VBN
cord-010604-3d37o05y	48	5	very	very	RB
cord-010604-3d37o05y	48	6	recently	recently	RB
cord-010604-3d37o05y	48	7	[	[	-LRB-
cord-010604-3d37o05y	48	8	40	40	CD
cord-010604-3d37o05y	48	9	]	]	-RRB-
cord-010604-3d37o05y	48	10	,	,	,
cord-010604-3d37o05y	48	11	and	and	CC
cord-010604-3d37o05y	48	12	thus	thus	RB
cord-010604-3d37o05y	48	13	is	be	VBZ
cord-010604-3d37o05y	48	14	mentioned	mention	VBN
cord-010604-3d37o05y	48	15	here	here	RB
cord-010604-3d37o05y	48	16	only	only	RB
cord-010604-3d37o05y	48	17	briefly	briefly	RB
cord-010604-3d37o05y	49	1	:	:	:
cord-010604-3d37o05y	49	2	Not	not	RB
cord-010604-3d37o05y	49	3	surprisingly	surprisingly	RB
cord-010604-3d37o05y	49	4	,	,	,
cord-010604-3d37o05y	49	5	the	the	DT
cord-010604-3d37o05y	49	6	first	first	JJ
cord-010604-3d37o05y	49	7	reported	report	VBD
cord-010604-3d37o05y	49	8	PTM	PTM	NNP
cord-010604-3d37o05y	49	9	of	of	IN
cord-010604-3d37o05y	49	10	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	49	11	was	be	VBD
cord-010604-3d37o05y	49	12	phosphorylation	phosphorylation	JJ
cord-010604-3d37o05y	49	13	.	.	.
cord-010604-3d37o05y	50	1	Originally	originally	RB
cord-010604-3d37o05y	50	2	,	,	,
cord-010604-3d37o05y	50	3	it	-PRON-	PRP
cord-010604-3d37o05y	50	4	was	be	VBD
cord-010604-3d37o05y	50	5	inferred	infer	VBN
cord-010604-3d37o05y	50	6	from	from	IN
cord-010604-3d37o05y	50	7	the	the	DT
cord-010604-3d37o05y	50	8	pattern	pattern	NN
cord-010604-3d37o05y	50	9	of	of	IN
cord-010604-3d37o05y	50	10	this	this	DT
cord-010604-3d37o05y	50	11	protein	protein	NN
cord-010604-3d37o05y	50	12	in	in	IN
cord-010604-3d37o05y	50	13	2D	2D	NNP
cord-010604-3d37o05y	50	14	gel	gel	NN
cord-010604-3d37o05y	50	15	electrophoresis	electrophoresis	NN
cord-010604-3d37o05y	50	16	and	and	CC
cord-010604-3d37o05y	50	17	the	the	DT
cord-010604-3d37o05y	50	18	modulation	modulation	NN
cord-010604-3d37o05y	50	19	of	of	IN
cord-010604-3d37o05y	50	20	this	this	DT
cord-010604-3d37o05y	50	21	pattern	pattern	NN
cord-010604-3d37o05y	50	22	by	by	IN
cord-010604-3d37o05y	50	23	the	the	DT
cord-010604-3d37o05y	50	24	use	use	NN
cord-010604-3d37o05y	50	25	of	of	IN
cord-010604-3d37o05y	50	26	kinase	kinase	NN
cord-010604-3d37o05y	50	27	inhibitors	inhibitor	NNS
cord-010604-3d37o05y	50	28	or	or	CC
cord-010604-3d37o05y	50	29	phosphatases	phosphatase	NNS
cord-010604-3d37o05y	50	30	[	[	-LRB-
cord-010604-3d37o05y	50	31	40	40	CD
cord-010604-3d37o05y	50	32	]	]	-RRB-
cord-010604-3d37o05y	50	33	[	[	-LRB-
cord-010604-3d37o05y	50	34	41	41	CD
cord-010604-3d37o05y	50	35	]	]	-RRB-
cord-010604-3d37o05y	50	36	[	[	-LRB-
cord-010604-3d37o05y	50	37	42	42	CD
cord-010604-3d37o05y	50	38	]	]	-RRB-
cord-010604-3d37o05y	50	39	.	.	.
cord-010604-3d37o05y	51	1	More	more	RBR
cord-010604-3d37o05y	51	2	recently	recently	RB
cord-010604-3d37o05y	51	3	,	,	,
cord-010604-3d37o05y	51	4	PTEN	PTEN	NNP
cord-010604-3d37o05y	51	5	-	-	HYPH
cord-010604-3d37o05y	51	6	induced	induce	VBN
cord-010604-3d37o05y	51	7	putative	putative	JJ
cord-010604-3d37o05y	51	8	kinase	kinase	NN
cord-010604-3d37o05y	51	9	1	1	CD
cord-010604-3d37o05y	51	10	(	(	-LRB-
cord-010604-3d37o05y	51	11	PINK1	PINK1	NNP
cord-010604-3d37o05y	51	12	)	)	-RRB-
cord-010604-3d37o05y	51	13	was	be	VBD
cord-010604-3d37o05y	51	14	found	find	VBN
cord-010604-3d37o05y	51	15	to	to	TO
cord-010604-3d37o05y	51	16	phosphorylate	phosphorylate	VB
cord-010604-3d37o05y	52	1	FKBP51	fkbp51	RB
cord-010604-3d37o05y	52	2	at	at	IN
cord-010604-3d37o05y	52	3	yet	yet	RB
cord-010604-3d37o05y	52	4	to	to	TO
cord-010604-3d37o05y	52	5	be	be	VB
cord-010604-3d37o05y	52	6	mapped	map	VBN
cord-010604-3d37o05y	52	7	serine	serine	NN
cord-010604-3d37o05y	52	8	residues	residue	NNS
cord-010604-3d37o05y	52	9	[	[	-LRB-
cord-010604-3d37o05y	52	10	43	43	CD
cord-010604-3d37o05y	52	11	]	]	-RRB-
cord-010604-3d37o05y	52	12	.	.	.
cord-010604-3d37o05y	53	1	Thereby	thereby	RB
cord-010604-3d37o05y	53	2	,	,	,
cord-010604-3d37o05y	53	3	PINK1	PINK1	NNP
cord-010604-3d37o05y	53	4	regulates	regulate	VBZ
cord-010604-3d37o05y	53	5	the	the	DT
cord-010604-3d37o05y	53	6	interaction	interaction	NN
cord-010604-3d37o05y	53	7	of	of	IN
cord-010604-3d37o05y	53	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	53	9	with	with	IN
cord-010604-3d37o05y	53	10	the	the	DT
cord-010604-3d37o05y	53	11	kinase	kinase	NN
cord-010604-3d37o05y	53	12	Akt1	Akt1	NNP
cord-010604-3d37o05y	53	13	and	and	CC
cord-010604-3d37o05y	53	14	the	the	DT
cord-010604-3d37o05y	53	15	phosphatase	phosphatase	NN
cord-010604-3d37o05y	53	16	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	53	17	[	[	-LRB-
cord-010604-3d37o05y	53	18	43	43	CD
cord-010604-3d37o05y	53	19	]	]	-RRB-
cord-010604-3d37o05y	53	20	.	.	.
cord-010604-3d37o05y	54	1	This	this	DT
cord-010604-3d37o05y	54	2	interaction	interaction	NN
cord-010604-3d37o05y	54	3	further	further	RB
cord-010604-3d37o05y	54	4	is	be	VBZ
cord-010604-3d37o05y	54	5	controlled	control	VBN
cord-010604-3d37o05y	54	6	by	by	IN
cord-010604-3d37o05y	54	7	acetylation	acetylation	NN
cord-010604-3d37o05y	54	8	of	of	IN
cord-010604-3d37o05y	54	9	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	54	10	at	at	IN
cord-010604-3d37o05y	54	11	lysines	lysines	NNP
cord-010604-3d37o05y	54	12	28	28	CD
cord-010604-3d37o05y	54	13	and	and	CC
cord-010604-3d37o05y	54	14	155	155	CD
cord-010604-3d37o05y	54	15	[	[	-LRB-
cord-010604-3d37o05y	54	16	44	44	CD
cord-010604-3d37o05y	54	17	]	]	-RRB-
cord-010604-3d37o05y	54	18	.	.	.
cord-010604-3d37o05y	55	1	The	the	DT
cord-010604-3d37o05y	55	2	sirtuin	sirtuin	NNP
cord-010604-3d37o05y	55	3	SIRT7	SIRT7	NNP
cord-010604-3d37o05y	55	4	has	have	VBZ
cord-010604-3d37o05y	55	5	been	be	VBN
cord-010604-3d37o05y	55	6	identified	identify	VBN
cord-010604-3d37o05y	55	7	as	as	IN
cord-010604-3d37o05y	55	8	deacetylase	deacetylase	NN
cord-010604-3d37o05y	55	9	acting	act	VBG
cord-010604-3d37o05y	55	10	at	at	IN
cord-010604-3d37o05y	55	11	these	these	DT
cord-010604-3d37o05y	55	12	sites	site	NNS
cord-010604-3d37o05y	55	13	[	[	-LRB-
cord-010604-3d37o05y	55	14	44	44	CD
cord-010604-3d37o05y	55	15	]	]	-RRB-
cord-010604-3d37o05y	55	16	.	.	.
cord-010604-3d37o05y	56	1	SUMOylation	sumoylation	NN
cord-010604-3d37o05y	56	2	of	of	IN
cord-010604-3d37o05y	56	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	56	4	was	be	VBD
cord-010604-3d37o05y	56	5	detected	detect	VBN
cord-010604-3d37o05y	56	6	and	and	CC
cord-010604-3d37o05y	56	7	mapped	map	VBN
cord-010604-3d37o05y	56	8	to	to	IN
cord-010604-3d37o05y	56	9	lysine	lysine	NN
cord-010604-3d37o05y	56	10	422	422	CD
cord-010604-3d37o05y	56	11	[	[	-LRB-
cord-010604-3d37o05y	56	12	45	45	CD
cord-010604-3d37o05y	56	13	]	]	-RRB-
cord-010604-3d37o05y	56	14	.	.	.
cord-010604-3d37o05y	57	1	It	-PRON-	PRP
cord-010604-3d37o05y	57	2	regulates	regulate	VBZ
cord-010604-3d37o05y	57	3	the	the	DT
cord-010604-3d37o05y	57	4	inhibitory	inhibitory	JJ
cord-010604-3d37o05y	57	5	action	action	NN
cord-010604-3d37o05y	57	6	of	of	IN
cord-010604-3d37o05y	57	7	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	57	8	on	on	IN
cord-010604-3d37o05y	57	9	GR	GR	NNP
cord-010604-3d37o05y	57	10	[	[	-LRB-
cord-010604-3d37o05y	57	11	45	45	CD
cord-010604-3d37o05y	57	12	]	]	-RRB-
cord-010604-3d37o05y	57	13	.	.	.
cord-010604-3d37o05y	58	1	The	the	DT
cord-010604-3d37o05y	58	2	first	first	JJ
cord-010604-3d37o05y	58	3	evidence	evidence	NN
cord-010604-3d37o05y	58	4	for	for	IN
cord-010604-3d37o05y	58	5	the	the	DT
cord-010604-3d37o05y	58	6	involvement	involvement	NN
cord-010604-3d37o05y	58	7	of	of	IN
cord-010604-3d37o05y	58	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	58	9	in	in	IN
cord-010604-3d37o05y	58	10	the	the	DT
cord-010604-3d37o05y	58	11	regulation	regulation	NN
cord-010604-3d37o05y	58	12	of	of	IN
cord-010604-3d37o05y	58	13	the	the	DT
cord-010604-3d37o05y	58	14	phosphoproteome	phosphoproteome	NN
cord-010604-3d37o05y	58	15	was	be	VBD
cord-010604-3d37o05y	58	16	provided	provide	VBN
cord-010604-3d37o05y	58	17	by	by	IN
cord-010604-3d37o05y	58	18	the	the	DT
cord-010604-3d37o05y	58	19	observation	observation	NN
cord-010604-3d37o05y	58	20	that	that	WDT
cord-010604-3d37o05y	58	21	FK506-bound	FK506-bound	NNP
cord-010604-3d37o05y	58	22	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	58	23	inhibits	inhibit	VBZ
cord-010604-3d37o05y	58	24	the	the	DT
cord-010604-3d37o05y	58	25	serine	serine	NN
cord-010604-3d37o05y	58	26	/	/	SYM
cord-010604-3d37o05y	58	27	threonine	threonine	NN
cord-010604-3d37o05y	58	28	-	-	HYPH
cord-010604-3d37o05y	58	29	phosphatase	phosphatase	NN
cord-010604-3d37o05y	58	30	calcineurin	calcineurin	NN
cord-010604-3d37o05y	58	31	(	(	-LRB-
cord-010604-3d37o05y	58	32	also	also	RB
cord-010604-3d37o05y	58	33	known	know	VBN
cord-010604-3d37o05y	58	34	as	as	IN
cord-010604-3d37o05y	58	35	protein	protein	NN
cord-010604-3d37o05y	58	36	phosphatase	phosphatase	NN
cord-010604-3d37o05y	58	37	2B	2b	CD
cord-010604-3d37o05y	58	38	)	)	-RRB-
cord-010604-3d37o05y	58	39	,	,	,
cord-010604-3d37o05y	58	40	thereby	thereby	RB
cord-010604-3d37o05y	58	41	inhibiting	inhibit	VBG
cord-010604-3d37o05y	58	42	nuclear	nuclear	JJ
cord-010604-3d37o05y	58	43	factor	factor	NN
cord-010604-3d37o05y	58	44	of	of	IN
cord-010604-3d37o05y	58	45	activated	activate	VBN
cord-010604-3d37o05y	58	46	T	T	NNP
cord-010604-3d37o05y	58	47	cells	cell	NNS
cord-010604-3d37o05y	58	48	(	(	-LRB-
cord-010604-3d37o05y	58	49	NFAT	NFAT	NNP
cord-010604-3d37o05y	58	50	)	)	-RRB-
cord-010604-3d37o05y	58	51	[	[	-LRB-
cord-010604-3d37o05y	58	52	46	46	CD
cord-010604-3d37o05y	58	53	,	,	,
cord-010604-3d37o05y	58	54	47	47	CD
cord-010604-3d37o05y	58	55	]	]	-RRB-
cord-010604-3d37o05y	58	56	.	.	.
cord-010604-3d37o05y	59	1	It	-PRON-	PRP
cord-010604-3d37o05y	59	2	also	also	RB
cord-010604-3d37o05y	59	3	has	have	VBZ
cord-010604-3d37o05y	59	4	been	be	VBN
cord-010604-3d37o05y	59	5	reported	report	VBN
cord-010604-3d37o05y	59	6	that	that	IN
cord-010604-3d37o05y	59	7	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	59	8	interacts	interact	VBZ
cord-010604-3d37o05y	59	9	with	with	IN
cord-010604-3d37o05y	59	10	calcineurin	calcineurin	NN
cord-010604-3d37o05y	59	11	in	in	IN
cord-010604-3d37o05y	59	12	the	the	DT
cord-010604-3d37o05y	59	13	absence	absence	NN
cord-010604-3d37o05y	59	14	of	of	IN
cord-010604-3d37o05y	59	15	FK506	fk506	JJ
cord-010604-3d37o05y	59	16	[	[	-LRB-
cord-010604-3d37o05y	59	17	48	48	CD
cord-010604-3d37o05y	59	18	]	]	-RRB-
cord-010604-3d37o05y	59	19	,	,	,
cord-010604-3d37o05y	59	20	which	which	WDT
cord-010604-3d37o05y	59	21	was	be	VBD
cord-010604-3d37o05y	59	22	not	not	RB
cord-010604-3d37o05y	59	23	observed	observe	VBN
cord-010604-3d37o05y	59	24	by	by	IN
cord-010604-3d37o05y	59	25	others	other	NNS
cord-010604-3d37o05y	59	26	[	[	-LRB-
cord-010604-3d37o05y	59	27	47	47	CD
cord-010604-3d37o05y	59	28	]	]	-RRB-
cord-010604-3d37o05y	59	29	.	.	.
cord-010604-3d37o05y	60	1	Nevertheless	nevertheless	RB
cord-010604-3d37o05y	60	2	,	,	,
cord-010604-3d37o05y	60	3	impacting	impact	VBG
cord-010604-3d37o05y	60	4	PTMs	ptm	NNS
cord-010604-3d37o05y	60	5	through	through	IN
cord-010604-3d37o05y	60	6	re	re	NN
cord-010604-3d37o05y	60	7	-	-	JJ
cord-010604-3d37o05y	60	8	arranging	arrange	VBG
cord-010604-3d37o05y	60	9	protein	protein	NNP
cord-010604-3d37o05y	60	10	association	association	NN
cord-010604-3d37o05y	60	11	of	of	IN
cord-010604-3d37o05y	60	12	kinases	kinase	NNS
cord-010604-3d37o05y	60	13	and	and	CC
cord-010604-3d37o05y	60	14	phosphatases	phosphatase	NNS
cord-010604-3d37o05y	60	15	as	as	IN
cord-010604-3d37o05y	60	16	in	in	IN
cord-010604-3d37o05y	60	17	the	the	DT
cord-010604-3d37o05y	60	18	case	case	NN
cord-010604-3d37o05y	60	19	of	of	IN
cord-010604-3d37o05y	60	20	calcineurin	calcineurin	NNP
cord-010604-3d37o05y	60	21	/	/	SYM
cord-010604-3d37o05y	60	22	NFAT	NFAT	NNP
cord-010604-3d37o05y	60	23	is	be	VBZ
cord-010604-3d37o05y	60	24	the	the	DT
cord-010604-3d37o05y	60	25	mode	mode	NN
cord-010604-3d37o05y	60	26	of	of	IN
cord-010604-3d37o05y	60	27	action	action	NN
cord-010604-3d37o05y	60	28	also	also	RB
cord-010604-3d37o05y	60	29	revealed	reveal	VBD
cord-010604-3d37o05y	60	30	for	for	IN
cord-010604-3d37o05y	60	31	the	the	DT
cord-010604-3d37o05y	60	32	effect	effect	NN
cord-010604-3d37o05y	60	33	of	of	IN
cord-010604-3d37o05y	60	34	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	60	35	on	on	IN
cord-010604-3d37o05y	60	36	many	many	JJ
cord-010604-3d37o05y	60	37	other	other	JJ
cord-010604-3d37o05y	60	38	signaling	signal	VBG
cord-010604-3d37o05y	60	39	pathways	pathway	NNS
cord-010604-3d37o05y	60	40	.	.	.
cord-010604-3d37o05y	61	1	The	the	DT
cord-010604-3d37o05y	61	2	inhibition	inhibition	NN
cord-010604-3d37o05y	61	3	of	of	IN
cord-010604-3d37o05y	61	4	calcineurin	calcineurin	NN
cord-010604-3d37o05y	61	5	by	by	IN
cord-010604-3d37o05y	61	6	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	61	7	is	be	VBZ
cord-010604-3d37o05y	61	8	reported	report	VBN
cord-010604-3d37o05y	61	9	to	to	TO
cord-010604-3d37o05y	61	10	also	also	RB
cord-010604-3d37o05y	61	11	affect	affect	VB
cord-010604-3d37o05y	61	12	the	the	DT
cord-010604-3d37o05y	61	13	nuclear	nuclear	JJ
cord-010604-3d37o05y	61	14	factor	factor	NN
cord-010604-3d37o05y	61	15	(	(	-LRB-
cord-010604-3d37o05y	61	16	NF)κB	NF)κB	NNP
cord-010604-3d37o05y	61	17	pathway	pathway	NN
cord-010604-3d37o05y	61	18	[	[	-LRB-
cord-010604-3d37o05y	61	19	49	49	CD
cord-010604-3d37o05y	61	20	]	]	-RRB-
cord-010604-3d37o05y	61	21	.	.	.
cord-010604-3d37o05y	62	1	In	in	IN
cord-010604-3d37o05y	62	2	this	this	DT
cord-010604-3d37o05y	62	3	pathway	pathway	NN
cord-010604-3d37o05y	62	4	,	,	,
cord-010604-3d37o05y	62	5	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	62	6	of	of	IN
cord-010604-3d37o05y	62	7	the	the	DT
cord-010604-3d37o05y	62	8	inhibitor	inhibitor	NN
cord-010604-3d37o05y	62	9	of	of	IN
cord-010604-3d37o05y	62	10	κB	κB	NNP
cord-010604-3d37o05y	62	11	(	(	-LRB-
cord-010604-3d37o05y	62	12	IκB	iκb	NN
cord-010604-3d37o05y	62	13	)	)	-RRB-
cord-010604-3d37o05y	62	14	by	by	IN
cord-010604-3d37o05y	62	15	the	the	DT
cord-010604-3d37o05y	62	16	kinase	kinase	NN
cord-010604-3d37o05y	62	17	of	of	IN
cord-010604-3d37o05y	62	18	IκB	iκb	NN
cord-010604-3d37o05y	62	19	(	(	-LRB-
cord-010604-3d37o05y	62	20	IKK	IKK	NNP
cord-010604-3d37o05y	62	21	)	)	-RRB-
cord-010604-3d37o05y	62	22	leads	lead	VBZ
cord-010604-3d37o05y	62	23	to	to	IN
cord-010604-3d37o05y	62	24	activation	activation	NN
cord-010604-3d37o05y	62	25	of	of	IN
cord-010604-3d37o05y	62	26	NFκB	NFκB	NNP
cord-010604-3d37o05y	62	27	[	[	-LRB-
cord-010604-3d37o05y	62	28	50	50	CD
cord-010604-3d37o05y	62	29	]	]	-RRB-
cord-010604-3d37o05y	62	30	.	.	.
cord-010604-3d37o05y	63	1	Therefore	therefore	RB
cord-010604-3d37o05y	63	2	,	,	,
cord-010604-3d37o05y	63	3	the	the	DT
cord-010604-3d37o05y	63	4	protein	protein	NN
cord-010604-3d37o05y	63	5	associations	association	NNS
cord-010604-3d37o05y	63	6	of	of	IN
cord-010604-3d37o05y	63	7	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	63	8	with	with	IN
cord-010604-3d37o05y	63	9	calcineurin	calcineurin	NNP
cord-010604-3d37o05y	63	10	as	as	RB
cord-010604-3d37o05y	63	11	well	well	RB
cord-010604-3d37o05y	63	12	as	as	IN
cord-010604-3d37o05y	63	13	with	with	IN
cord-010604-3d37o05y	63	14	IKKα	IKKα	NNS
cord-010604-3d37o05y	63	15	and	and	CC
cord-010604-3d37o05y	63	16	other	other	JJ
cord-010604-3d37o05y	63	17	kinases	kinase	NNS
cord-010604-3d37o05y	63	18	of	of	IN
cord-010604-3d37o05y	63	19	the	the	DT
cord-010604-3d37o05y	63	20	NFκB	NFκB	NNP
cord-010604-3d37o05y	63	21	pathway	pathway	NN
cord-010604-3d37o05y	63	22	[	[	-LRB-
cord-010604-3d37o05y	63	23	51	51	CD
cord-010604-3d37o05y	63	24	]	]	-RRB-
cord-010604-3d37o05y	63	25	support	support	VBP
cord-010604-3d37o05y	63	26	a	a	DT
cord-010604-3d37o05y	63	27	model	model	NN
cord-010604-3d37o05y	63	28	where	where	WRB
cord-010604-3d37o05y	63	29	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	63	30	impacts	impact	NNS
cord-010604-3d37o05y	63	31	NFκB	nfκb	VBP
cord-010604-3d37o05y	63	32	activity	activity	NN
cord-010604-3d37o05y	63	33	through	through	IN
cord-010604-3d37o05y	63	34	re	re	NN
cord-010604-3d37o05y	63	35	-	-	JJ
cord-010604-3d37o05y	63	36	setting	set	VBG
cord-010604-3d37o05y	63	37	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	63	38	at	at	IN
cord-010604-3d37o05y	63	39	multiple	multiple	JJ
cord-010604-3d37o05y	63	40	levels	level	NNS
cord-010604-3d37o05y	63	41	with	with	IN
cord-010604-3d37o05y	63	42	variable	variable	JJ
cord-010604-3d37o05y	63	43	outcome	outcome	NN
cord-010604-3d37o05y	63	44	[	[	-LRB-
cord-010604-3d37o05y	63	45	11	11	CD
cord-010604-3d37o05y	63	46	]	]	-RRB-
cord-010604-3d37o05y	63	47	.	.	.
cord-010604-3d37o05y	64	1	For	for	IN
cord-010604-3d37o05y	64	2	example	example	NN
cord-010604-3d37o05y	64	3	,	,	,
cord-010604-3d37o05y	64	4	a	a	DT
cord-010604-3d37o05y	64	5	direct	direct	JJ
cord-010604-3d37o05y	64	6	association	association	NN
cord-010604-3d37o05y	64	7	between	between	IN
cord-010604-3d37o05y	64	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	64	9	and	and	CC
cord-010604-3d37o05y	64	10	both	both	CC
cord-010604-3d37o05y	64	11	TNF	TNF	NNP
cord-010604-3d37o05y	64	12	receptor	receptor	NN
cord-010604-3d37o05y	64	13	-	-	HYPH
cord-010604-3d37o05y	64	14	associated	associate	VBN
cord-010604-3d37o05y	64	15	factor	factor	NN
cord-010604-3d37o05y	64	16	2	2	CD
cord-010604-3d37o05y	64	17	(	(	-LRB-
cord-010604-3d37o05y	64	18	TRAF2	TRAF2	NNP
cord-010604-3d37o05y	64	19	)	)	-RRB-
cord-010604-3d37o05y	64	20	and	and	CC
cord-010604-3d37o05y	64	21	IKKγ	IKKγ	NNS
cord-010604-3d37o05y	64	22	was	be	VBD
cord-010604-3d37o05y	64	23	found	find	VBN
cord-010604-3d37o05y	64	24	[	[	-LRB-
cord-010604-3d37o05y	64	25	52	52	CD
cord-010604-3d37o05y	64	26	]	]	-RRB-
cord-010604-3d37o05y	64	27	.	.	.
cord-010604-3d37o05y	65	1	TRAF2	TRAF2	NNP
cord-010604-3d37o05y	65	2	catalyzes	catalyze	VBZ
cord-010604-3d37o05y	65	3	K63-linked	K63-linked	NNP
cord-010604-3d37o05y	65	4	poly	poly	NN
cord-010604-3d37o05y	65	5	-	-	HYPH
cord-010604-3d37o05y	65	6	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	65	7	of	of	IN
cord-010604-3d37o05y	65	8	receptor	receptor	NN
cord-010604-3d37o05y	65	9	-	-	HYPH
cord-010604-3d37o05y	65	10	interacting	interact	VBG
cord-010604-3d37o05y	65	11	protein	protein	NN
cord-010604-3d37o05y	65	12	1	1	CD
cord-010604-3d37o05y	65	13	(	(	-LRB-
cord-010604-3d37o05y	65	14	RIP1	RIP1	NNP
cord-010604-3d37o05y	65	15	)	)	-RRB-
cord-010604-3d37o05y	65	16	in	in	IN
cord-010604-3d37o05y	65	17	response	response	NN
cord-010604-3d37o05y	65	18	to	to	IN
cord-010604-3d37o05y	65	19	TNFα	TNFα	NNP
cord-010604-3d37o05y	65	20	,	,	,
cord-010604-3d37o05y	65	21	thereby	thereby	RB
cord-010604-3d37o05y	65	22	facilitating	facilitate	VBG
cord-010604-3d37o05y	65	23	the	the	DT
cord-010604-3d37o05y	65	24	recruitment	recruitment	NN
cord-010604-3d37o05y	65	25	of	of	IN
cord-010604-3d37o05y	65	26	the	the	DT
cord-010604-3d37o05y	65	27	IKK	IKK	NNP
cord-010604-3d37o05y	65	28	complex	complex	NN
cord-010604-3d37o05y	65	29	to	to	IN
cord-010604-3d37o05y	65	30	its	-PRON-	PRP$
cord-010604-3d37o05y	65	31	upstream	upstream	JJ
cord-010604-3d37o05y	65	32	activating	activating	NN
cord-010604-3d37o05y	65	33	kinase	kinase	NN
cord-010604-3d37o05y	65	34	TAK1	TAK1	NNP
cord-010604-3d37o05y	65	35	(	(	-LRB-
cord-010604-3d37o05y	65	36	transforming	transform	VBG
cord-010604-3d37o05y	65	37	growth	growth	NN
cord-010604-3d37o05y	65	38	factorbeta	factorbeta	NN
cord-010604-3d37o05y	65	39	activated	activate	VBN
cord-010604-3d37o05y	65	40	kinase	kinase	NN
cord-010604-3d37o05y	65	41	1	1	CD
cord-010604-3d37o05y	65	42	)	)	-RRB-
cord-010604-3d37o05y	66	1	[	[	-LRB-
cord-010604-3d37o05y	66	2	53	53	CD
cord-010604-3d37o05y	66	3	,	,	,
cord-010604-3d37o05y	66	4	54	54	CD
cord-010604-3d37o05y	66	5	]	]	-RRB-
cord-010604-3d37o05y	66	6	.	.	.
cord-010604-3d37o05y	67	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	67	2	enhances	enhance	VBZ
cord-010604-3d37o05y	67	3	and	and	CC
cord-010604-3d37o05y	67	4	shapes	shape	NNS
cord-010604-3d37o05y	67	5	this	this	DT
cord-010604-3d37o05y	67	6	polyubiquitin	polyubiquitin	NNP
cord-010604-3d37o05y	67	7	-	-	HYPH
cord-010604-3d37o05y	67	8	mediated	mediate	VBN
cord-010604-3d37o05y	67	9	interaction	interaction	NN
cord-010604-3d37o05y	67	10	,	,	,
cord-010604-3d37o05y	67	11	thereby	thereby	RB
cord-010604-3d37o05y	67	12	changing	change	VBG
cord-010604-3d37o05y	67	13	the	the	DT
cord-010604-3d37o05y	67	14	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	67	15	of	of	IN
cord-010604-3d37o05y	67	16	IKK	IKK	NNP
cord-010604-3d37o05y	67	17	and	and	CC
cord-010604-3d37o05y	67	18	IκB	iκb	NN
cord-010604-3d37o05y	67	19	and	and	CC
cord-010604-3d37o05y	67	20	thus	thus	RB
cord-010604-3d37o05y	67	21	the	the	DT
cord-010604-3d37o05y	67	22	activity	activity	NN
cord-010604-3d37o05y	67	23	of	of	IN
cord-010604-3d37o05y	67	24	NFκB	NFκB	NNP
cord-010604-3d37o05y	67	25	[	[	-LRB-
cord-010604-3d37o05y	67	26	52	52	CD
cord-010604-3d37o05y	67	27	]	]	-RRB-
cord-010604-3d37o05y	67	28	.	.	.
cord-010604-3d37o05y	68	1	The	the	DT
cord-010604-3d37o05y	68	2	serine	serine	NN
cord-010604-3d37o05y	68	3	/	/	SYM
cord-010604-3d37o05y	68	4	threonine	threonine	NN
cord-010604-3d37o05y	68	5	kinase	kinase	NN
cord-010604-3d37o05y	68	6	Akt	Akt	NNP
cord-010604-3d37o05y	68	7	(	(	-LRB-
cord-010604-3d37o05y	68	8	also	also	RB
cord-010604-3d37o05y	68	9	known	know	VBN
cord-010604-3d37o05y	68	10	as	as	IN
cord-010604-3d37o05y	68	11	protein	protein	NN
cord-010604-3d37o05y	68	12	kinase	kinase	NN
cord-010604-3d37o05y	68	13	B	B	NNP
cord-010604-3d37o05y	68	14	)	)	-RRB-
cord-010604-3d37o05y	68	15	is	be	VBZ
cord-010604-3d37o05y	68	16	another	another	DT
cord-010604-3d37o05y	68	17	well	well	RB
cord-010604-3d37o05y	68	18	-	-	HYPH
cord-010604-3d37o05y	68	19	examined	examine	VBN
cord-010604-3d37o05y	68	20	example	example	NN
cord-010604-3d37o05y	68	21	of	of	IN
cord-010604-3d37o05y	68	22	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	68	23	's	's	POS
cord-010604-3d37o05y	68	24	impact	impact	NN
cord-010604-3d37o05y	68	25	on	on	IN
cord-010604-3d37o05y	68	26	PTMs	ptm	NNS
cord-010604-3d37o05y	68	27	through	through	IN
cord-010604-3d37o05y	68	28	organizing	organize	VBG
cord-010604-3d37o05y	68	29	protein	protein	NN
cord-010604-3d37o05y	68	30	complexes	complex	NNS
cord-010604-3d37o05y	68	31	.	.	.
cord-010604-3d37o05y	69	1	Akt	Akt	NNP
cord-010604-3d37o05y	69	2	is	be	VBZ
cord-010604-3d37o05y	69	3	activated	activate	VBN
cord-010604-3d37o05y	69	4	by	by	IN
cord-010604-3d37o05y	69	5	step	step	NN
cord-010604-3d37o05y	69	6	-	-	HYPH
cord-010604-3d37o05y	69	7	wise	wise	JJ
cord-010604-3d37o05y	69	8	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	69	9	in	in	IN
cord-010604-3d37o05y	69	10	response	response	NN
cord-010604-3d37o05y	69	11	to	to	IN
cord-010604-3d37o05y	69	12	extracellular	extracellular	JJ
cord-010604-3d37o05y	69	13	signals	signal	NNS
cord-010604-3d37o05y	69	14	that	that	WDT
cord-010604-3d37o05y	69	15	involves	involve	VBZ
cord-010604-3d37o05y	69	16	its	-PRON-	PRP$
cord-010604-3d37o05y	69	17	translocation	translocation	NN
cord-010604-3d37o05y	69	18	from	from	IN
cord-010604-3d37o05y	69	19	the	the	DT
cord-010604-3d37o05y	69	20	cytoplasm	cytoplasm	NN
cord-010604-3d37o05y	69	21	to	to	IN
cord-010604-3d37o05y	69	22	the	the	DT
cord-010604-3d37o05y	69	23	cell	cell	NN
cord-010604-3d37o05y	69	24	membrane	membrane	NN
cord-010604-3d37o05y	69	25	[	[	-LRB-
cord-010604-3d37o05y	69	26	55	55	CD
cord-010604-3d37o05y	69	27	,	,	,
cord-010604-3d37o05y	69	28	56	56	CD
cord-010604-3d37o05y	69	29	]	]	-RRB-
cord-010604-3d37o05y	69	30	.	.	.
cord-010604-3d37o05y	70	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	70	2	employs	employ	VBZ
cord-010604-3d37o05y	70	3	its	-PRON-	PRP$
cord-010604-3d37o05y	70	4	ability	ability	NN
cord-010604-3d37o05y	70	5	to	to	TO
cord-010604-3d37o05y	70	6	interact	interact	VB
cord-010604-3d37o05y	70	7	with	with	IN
cord-010604-3d37o05y	70	8	various	various	JJ
cord-010604-3d37o05y	70	9	proteins	protein	NNS
cord-010604-3d37o05y	70	10	,	,	,
cord-010604-3d37o05y	70	11	frequently	frequently	RB
cord-010604-3d37o05y	70	12	referred	refer	VBD
cord-010604-3d37o05y	70	13	to	to	IN
cord-010604-3d37o05y	70	14	as	as	IN
cord-010604-3d37o05y	70	15	scaffolding	scaffolding	NN
cord-010604-3d37o05y	70	16	,	,	,
cord-010604-3d37o05y	70	17	to	to	TO
cord-010604-3d37o05y	70	18	recruit	recruit	VB
cord-010604-3d37o05y	70	19	the	the	DT
cord-010604-3d37o05y	70	20	phosphatase	phosphatase	NN
cord-010604-3d37o05y	70	21	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	70	22	that	that	IN
cord-010604-3d37o05y	70	23	de	de	NN
cord-010604-3d37o05y	70	24	-	-	VBZ
cord-010604-3d37o05y	70	25	phosphorylates	phosphorylate	VBZ
cord-010604-3d37o05y	70	26	and	and	CC
cord-010604-3d37o05y	70	27	thereby	thereby	RB
cord-010604-3d37o05y	70	28	inactivates	inactivate	VBZ
cord-010604-3d37o05y	70	29	Akt	Akt	NNP
cord-010604-3d37o05y	70	30	[	[	-LRB-
cord-010604-3d37o05y	70	31	57	57	CD
cord-010604-3d37o05y	70	32	,	,	,
cord-010604-3d37o05y	70	33	58	58	CD
cord-010604-3d37o05y	70	34	]	]	-RRB-
cord-010604-3d37o05y	70	35	(	(	-LRB-
cord-010604-3d37o05y	70	36	Figure	figure	NN
cord-010604-3d37o05y	70	37	1A	1a	NN
cord-010604-3d37o05y	70	38	)	)	-RRB-
cord-010604-3d37o05y	70	39	.	.	.
cord-010604-3d37o05y	71	1	Akt	Akt	NNP
cord-010604-3d37o05y	71	2	is	be	VBZ
cord-010604-3d37o05y	71	3	a	a	DT
cord-010604-3d37o05y	71	4	central	central	JJ
cord-010604-3d37o05y	71	5	pathway	pathway	NN
cord-010604-3d37o05y	71	6	regulator	regulator	NN
cord-010604-3d37o05y	71	7	that	that	WDT
cord-010604-3d37o05y	71	8	inhibits	inhibit	VBZ
cord-010604-3d37o05y	71	9	apoptosis	apoptosis	NN
cord-010604-3d37o05y	71	10	and	and	CC
cord-010604-3d37o05y	71	11	promotes	promote	VBZ
cord-010604-3d37o05y	71	12	cell	cell	NN
cord-010604-3d37o05y	71	13	growth	growth	NN
cord-010604-3d37o05y	71	14	[	[	-LRB-
cord-010604-3d37o05y	71	15	59	59	CD
cord-010604-3d37o05y	71	16	]	]	-RRB-
cord-010604-3d37o05y	71	17	.	.	.
cord-010604-3d37o05y	72	1	Accordingly	accordingly	RB
cord-010604-3d37o05y	72	2	,	,	,
cord-010604-3d37o05y	72	3	FKBP51	fkbp51	JJ
cord-010604-3d37o05y	72	4	expression	expression	NN
cord-010604-3d37o05y	72	5	is	be	VBZ
cord-010604-3d37o05y	72	6	enhanced	enhance	VBN
cord-010604-3d37o05y	72	7	in	in	IN
cord-010604-3d37o05y	72	8	most	most	JJS
cord-010604-3d37o05y	72	9	cancer	cancer	NN
cord-010604-3d37o05y	72	10	types	type	NNS
cord-010604-3d37o05y	72	11	and	and	CC
cord-010604-3d37o05y	72	12	is	be	VBZ
cord-010604-3d37o05y	72	13	linked	link	VBN
cord-010604-3d37o05y	72	14	to	to	IN
cord-010604-3d37o05y	72	15	resistance	resistance	NN
cord-010604-3d37o05y	72	16	to	to	IN
cord-010604-3d37o05y	72	17	chemotherapy	chemotherapy	NN
cord-010604-3d37o05y	72	18	[	[	-LRB-
cord-010604-3d37o05y	72	19	57	57	CD
cord-010604-3d37o05y	72	20	,	,	,
cord-010604-3d37o05y	72	21	[	[	-LRB-
cord-010604-3d37o05y	72	22	60	60	CD
cord-010604-3d37o05y	72	23	]	]	-RRB-
cord-010604-3d37o05y	72	24	[	[	-LRB-
cord-010604-3d37o05y	72	25	61	61	CD
cord-010604-3d37o05y	72	26	]	]	-RRB-
cord-010604-3d37o05y	72	27	[	[	-LRB-
cord-010604-3d37o05y	72	28	62	62	CD
cord-010604-3d37o05y	72	29	]	]	-RRB-
cord-010604-3d37o05y	72	30	.	.	.
cord-010604-3d37o05y	73	1	Evidence	evidence	NN
cord-010604-3d37o05y	73	2	has	have	VBZ
cord-010604-3d37o05y	73	3	also	also	RB
cord-010604-3d37o05y	73	4	been	be	VBN
cord-010604-3d37o05y	73	5	provided	provide	VBN
cord-010604-3d37o05y	73	6	that	that	IN
cord-010604-3d37o05y	73	7	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	73	8	mediates	mediate	VBZ
cord-010604-3d37o05y	73	9	the	the	DT
cord-010604-3d37o05y	73	10	inactivation	inactivation	NN
cord-010604-3d37o05y	73	11	of	of	IN
cord-010604-3d37o05y	73	12	Akt	Akt	NNP
cord-010604-3d37o05y	73	13	induced	induce	VBN
cord-010604-3d37o05y	73	14	by	by	IN
cord-010604-3d37o05y	73	15	stress	stress	NN
cord-010604-3d37o05y	73	16	[	[	-LRB-
cord-010604-3d37o05y	73	17	58	58	CD
cord-010604-3d37o05y	73	18	]	]	-RRB-
cord-010604-3d37o05y	73	19	.	.	.
cord-010604-3d37o05y	74	1	Thus	thus	RB
cord-010604-3d37o05y	74	2	,	,	,
cord-010604-3d37o05y	74	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	74	4	may	may	MD
cord-010604-3d37o05y	74	5	also	also	RB
cord-010604-3d37o05y	74	6	relay	relay	VB
cord-010604-3d37o05y	74	7	the	the	DT
cord-010604-3d37o05y	74	8	effect	effect	NN
cord-010604-3d37o05y	74	9	of	of	IN
cord-010604-3d37o05y	74	10	stress	stress	NN
cord-010604-3d37o05y	74	11	on	on	IN
cord-010604-3d37o05y	74	12	the	the	DT
cord-010604-3d37o05y	74	13	phosphoproteome	phosphoproteome	NN
cord-010604-3d37o05y	74	14	[	[	-LRB-
cord-010604-3d37o05y	74	15	11	11	CD
cord-010604-3d37o05y	74	16	]	]	-RRB-
cord-010604-3d37o05y	74	17	.	.	.
cord-010604-3d37o05y	75	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	75	2	's	's	POS
cord-010604-3d37o05y	75	3	effect	effect	NN
cord-010604-3d37o05y	75	4	on	on	IN
cord-010604-3d37o05y	75	5	Akt	Akt	NNP
cord-010604-3d37o05y	75	6	also	also	RB
cord-010604-3d37o05y	75	7	alters	alter	VBZ
cord-010604-3d37o05y	75	8	downstream	downstream	JJ
cord-010604-3d37o05y	75	9	PTM	PTM	NNP
cord-010604-3d37o05y	75	10	-	-	HYPH
cord-010604-3d37o05y	75	11	dependent	dependent	JJ
cord-010604-3d37o05y	75	12	pathways	pathway	NNS
cord-010604-3d37o05y	75	13	.	.	.
cord-010604-3d37o05y	76	1	For	for	IN
cord-010604-3d37o05y	76	2	example	example	NN
cord-010604-3d37o05y	76	3	,	,	,
cord-010604-3d37o05y	76	4	through	through	IN
cord-010604-3d37o05y	76	5	Akt1	Akt1	NNP
cord-010604-3d37o05y	76	6	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	76	7	impacts	impact	NNS
cord-010604-3d37o05y	76	8	p38	p38	CD
cord-010604-3d37o05y	76	9	MAPK	MAPK	NNP
cord-010604-3d37o05y	76	10	,	,	,
cord-010604-3d37o05y	76	11	thereby	thereby	RB
cord-010604-3d37o05y	76	12	differentially	differentially	RB
cord-010604-3d37o05y	76	13	regulating	regulate	VBG
cord-010604-3d37o05y	76	14	the	the	DT
cord-010604-3d37o05y	76	15	transcription	transcription	NN
cord-010604-3d37o05y	76	16	factors	factor	NNS
cord-010604-3d37o05y	76	17	GR	GR	NNP
cord-010604-3d37o05y	76	18	and	and	CC
cord-010604-3d37o05y	76	19	peroxisome	peroxisome	NN
cord-010604-3d37o05y	76	20	proliferator	proliferator	NN
cord-010604-3d37o05y	76	21	-	-	HYPH
cord-010604-3d37o05y	76	22	activated	activate	VBN
cord-010604-3d37o05y	76	23	receptor	receptor	NN
cord-010604-3d37o05y	76	24	-	-	HYPH
cord-010604-3d37o05y	76	25	γ	γ	NN
cord-010604-3d37o05y	76	26	[	[	-LRB-
cord-010604-3d37o05y	76	27	63	63	CD
cord-010604-3d37o05y	76	28	]	]	-RRB-
cord-010604-3d37o05y	76	29	.	.	.
cord-010604-3d37o05y	77	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	77	2	also	also	RB
cord-010604-3d37o05y	77	3	governs	govern	VBZ
cord-010604-3d37o05y	77	4	the	the	DT
cord-010604-3d37o05y	77	5	effects	effect	NNS
cord-010604-3d37o05y	77	6	of	of	IN
cord-010604-3d37o05y	77	7	Akt1	Akt1	NNP
cord-010604-3d37o05y	77	8	on	on	IN
cord-010604-3d37o05y	77	9	its	-PRON-	PRP$
cord-010604-3d37o05y	77	10	targets	target	NNS
cord-010604-3d37o05y	77	11	Beclin	Beclin	NNP
cord-010604-3d37o05y	77	12	1	1	CD
cord-010604-3d37o05y	77	13	(	(	-LRB-
cord-010604-3d37o05y	77	14	BECN1	BECN1	NNP
cord-010604-3d37o05y	77	15	)	)	-RRB-
cord-010604-3d37o05y	77	16	and	and	CC
cord-010604-3d37o05y	77	17	S	s	NN
cord-010604-3d37o05y	77	18	-	-	HYPH
cord-010604-3d37o05y	77	19	phase	phase	NN
cord-010604-3d37o05y	77	20	kinase	kinase	NN
cord-010604-3d37o05y	77	21	-	-	HYPH
cord-010604-3d37o05y	77	22	associated	associate	VBN
cord-010604-3d37o05y	77	23	protein	protein	NN
cord-010604-3d37o05y	77	24	2	2	CD
cord-010604-3d37o05y	77	25	(	(	-LRB-
cord-010604-3d37o05y	77	26	SKP2	SKP2	NNP
cord-010604-3d37o05y	77	27	)	)	-RRB-
cord-010604-3d37o05y	77	28	,	,	,
cord-010604-3d37o05y	77	29	constituting	constitute	VBG
cord-010604-3d37o05y	77	30	a	a	DT
cord-010604-3d37o05y	77	31	link	link	NN
cord-010604-3d37o05y	77	32	to	to	TO
cord-010604-3d37o05y	77	33	autophagy	autophagy	VB
cord-010604-3d37o05y	77	34	as	as	IN
cord-010604-3d37o05y	77	35	detailed	detail	VBN
cord-010604-3d37o05y	77	36	below	below	IN
cord-010604-3d37o05y	77	37	[	[	-LRB-
cord-010604-3d37o05y	77	38	58	58	CD
cord-010604-3d37o05y	77	39	,	,	,
cord-010604-3d37o05y	77	40	64	64	CD
cord-010604-3d37o05y	77	41	,	,	,
cord-010604-3d37o05y	77	42	65	65	CD
cord-010604-3d37o05y	77	43	]	]	-RRB-
cord-010604-3d37o05y	77	44	.	.	.
cord-010604-3d37o05y	78	1	[	[	-LRB-
cord-010604-3d37o05y	78	2	58	58	CD
cord-010604-3d37o05y	78	3	,	,	,
cord-010604-3d37o05y	78	4	64	64	CD
cord-010604-3d37o05y	78	5	,	,	,
cord-010604-3d37o05y	78	6	65	65	CD
cord-010604-3d37o05y	78	7	]	]	-RRB-
cord-010604-3d37o05y	78	8	.	.	.
cord-010604-3d37o05y	79	1	The	the	DT
cord-010604-3d37o05y	79	2	recruitment	recruitment	NN
cord-010604-3d37o05y	79	3	of	of	IN
cord-010604-3d37o05y	79	4	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	79	5	leads	lead	VBZ
cord-010604-3d37o05y	79	6	to	to	TO
cord-010604-3d37o05y	79	7	lower	lower	VB
cord-010604-3d37o05y	79	8	Akt	Akt	NNP
cord-010604-3d37o05y	79	9	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	79	10	and	and	CC
cord-010604-3d37o05y	79	11	activity	activity	NN
cord-010604-3d37o05y	79	12	,	,	,
cord-010604-3d37o05y	79	13	entailing	entail	VBG
cord-010604-3d37o05y	79	14	less	less	JJR
cord-010604-3d37o05y	79	15	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	79	16	of	of	IN
cord-010604-3d37o05y	79	17	BECN1	becn1	NN
cord-010604-3d37o05y	79	18	and	and	CC
cord-010604-3d37o05y	79	19	of	of	IN
cord-010604-3d37o05y	79	20	the	the	DT
cord-010604-3d37o05y	79	21	E3-ligase	E3-ligase	NNP
cord-010604-3d37o05y	79	22	SKP2	SKP2	NNP
cord-010604-3d37o05y	79	23	.	.	.
cord-010604-3d37o05y	80	1	Thereby	thereby	RB
cord-010604-3d37o05y	80	2	,	,	,
cord-010604-3d37o05y	80	3	SKP2	SKP2	NNP
cord-010604-3d37o05y	80	4	is	be	VBZ
cord-010604-3d37o05y	80	5	less	less	RBR
cord-010604-3d37o05y	80	6	active	active	JJ
cord-010604-3d37o05y	80	7	resulting	resulting	NN
cord-010604-3d37o05y	80	8	in	in	IN
cord-010604-3d37o05y	80	9	lower	low	JJR
cord-010604-3d37o05y	80	10	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	80	11	of	of	IN
cord-010604-3d37o05y	80	12	BECN1	BECN1	NNP
cord-010604-3d37o05y	80	13	.	.	.
cord-010604-3d37o05y	81	1	Whether	whether	IN
cord-010604-3d37o05y	81	2	or	or	CC
cord-010604-3d37o05y	81	3	not	not	RB
cord-010604-3d37o05y	81	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	81	5	associates	associate	NNS
cord-010604-3d37o05y	81	6	with	with	IN
cord-010604-3d37o05y	81	7	all	all	PDT
cord-010604-3d37o05y	81	8	these	these	DT
cord-010604-3d37o05y	81	9	proteins	protein	NNS
cord-010604-3d37o05y	81	10	in	in	IN
cord-010604-3d37o05y	81	11	one	one	CD
cord-010604-3d37o05y	81	12	complex	complex	NN
cord-010604-3d37o05y	81	13	remains	remain	VBZ
cord-010604-3d37o05y	81	14	to	to	TO
cord-010604-3d37o05y	81	15	be	be	VB
cord-010604-3d37o05y	81	16	elucidated	elucidate	VBN
cord-010604-3d37o05y	81	17	.	.	.
cord-010604-3d37o05y	82	1	Another	another	DT
cord-010604-3d37o05y	82	2	downstream	downstream	JJ
cord-010604-3d37o05y	82	3	target	target	NN
cord-010604-3d37o05y	82	4	of	of	IN
cord-010604-3d37o05y	82	5	Akt	Akt	NNP
cord-010604-3d37o05y	82	6	is	be	VBZ
cord-010604-3d37o05y	82	7	glycogen	glycogen	NN
cord-010604-3d37o05y	83	1	synthase	synthase	NN
cord-010604-3d37o05y	83	2	kinase	kinase	VBZ
cord-010604-3d37o05y	83	3	3β	3β	CD
cord-010604-3d37o05y	83	4	(	(	-LRB-
cord-010604-3d37o05y	83	5	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	83	6	)	)	-RRB-
cord-010604-3d37o05y	84	1	[	[	-LRB-
cord-010604-3d37o05y	84	2	66	66	CD
cord-010604-3d37o05y	84	3	]	]	-RRB-
cord-010604-3d37o05y	84	4	.	.	.
cord-010604-3d37o05y	85	1	Consistent	consistent	JJ
cord-010604-3d37o05y	85	2	with	with	IN
cord-010604-3d37o05y	85	3	the	the	DT
cord-010604-3d37o05y	85	4	inhibitory	inhibitory	JJ
cord-010604-3d37o05y	85	5	effect	effect	NN
cord-010604-3d37o05y	85	6	of	of	IN
cord-010604-3d37o05y	85	7	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	85	8	on	on	IN
cord-010604-3d37o05y	85	9	Akt1	Akt1	NNP
cord-010604-3d37o05y	85	10	,	,	,
cord-010604-3d37o05y	85	11	it	-PRON-	PRP
cord-010604-3d37o05y	85	12	has	have	VBZ
cord-010604-3d37o05y	85	13	been	be	VBN
cord-010604-3d37o05y	85	14	reported	report	VBN
cord-010604-3d37o05y	85	15	that	that	DT
cord-010604-3d37o05y	85	16	overexpression	overexpression	NN
cord-010604-3d37o05y	85	17	of	of	IN
cord-010604-3d37o05y	85	18	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	85	19	decreased	decrease	VBD
cord-010604-3d37o05y	85	20	the	the	DT
cord-010604-3d37o05y	85	21	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	85	22	of	of	IN
cord-010604-3d37o05y	85	23	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	85	24	at	at	IN
cord-010604-3d37o05y	85	25	serine	serine	NN
cord-010604-3d37o05y	85	26	9	9	CD
cord-010604-3d37o05y	85	27	[	[	-LRB-
cord-010604-3d37o05y	85	28	57	57	CD
cord-010604-3d37o05y	85	29	]	]	-RRB-
cord-010604-3d37o05y	85	30	.	.	.
cord-010604-3d37o05y	86	1	However	however	RB
cord-010604-3d37o05y	86	2	,	,	,
cord-010604-3d37o05y	86	3	it	-PRON-	PRP
cord-010604-3d37o05y	86	4	also	also	RB
cord-010604-3d37o05y	86	5	has	have	VBZ
cord-010604-3d37o05y	86	6	been	be	VBN
cord-010604-3d37o05y	86	7	found	find	VBN
cord-010604-3d37o05y	86	8	that	that	IN
cord-010604-3d37o05y	86	9	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	86	10	associates	associate	NNS
cord-010604-3d37o05y	86	11	with	with	IN
cord-010604-3d37o05y	86	12	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	86	13	,	,	,
cord-010604-3d37o05y	86	14	and	and	CC
cord-010604-3d37o05y	86	15	increases	increase	VBZ
cord-010604-3d37o05y	86	16	its	-PRON-	PRP$
cord-010604-3d37o05y	86	17	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	86	18	[	[	-LRB-
cord-010604-3d37o05y	86	19	67	67	CD
cord-010604-3d37o05y	86	20	]	]	-RRB-
cord-010604-3d37o05y	86	21	.	.	.
cord-010604-3d37o05y	87	1	This	this	DT
cord-010604-3d37o05y	87	2	appears	appear	VBZ
cord-010604-3d37o05y	87	3	to	to	TO
cord-010604-3d37o05y	87	4	be	be	VB
cord-010604-3d37o05y	87	5	accomplished	accomplish	VBN
cord-010604-3d37o05y	87	6	through	through	IN
cord-010604-3d37o05y	87	7	rearrangement	rearrangement	NN
cord-010604-3d37o05y	87	8	of	of	IN
cord-010604-3d37o05y	87	9	the	the	DT
cord-010604-3d37o05y	87	10	protein	protein	NN
cord-010604-3d37o05y	87	11	heterocomplex	heterocomplex	NN
cord-010604-3d37o05y	87	12	governing	govern	VBG
cord-010604-3d37o05y	87	13	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	87	14	and	and	CC
cord-010604-3d37o05y	87	15	thus	thus	RB
cord-010604-3d37o05y	87	16	the	the	DT
cord-010604-3d37o05y	87	17	activity	activity	NN
cord-010604-3d37o05y	87	18	of	of	IN
cord-010604-3d37o05y	87	19	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	87	20	.	.	.
cord-010604-3d37o05y	88	1	More	more	RBR
cord-010604-3d37o05y	88	2	specifically	specifically	RB
cord-010604-3d37o05y	88	3	,	,	,
cord-010604-3d37o05y	88	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	88	5	recruits	recruit	VBZ
cord-010604-3d37o05y	88	6	cyclin	cyclin	NN
cord-010604-3d37o05y	88	7	-	-	HYPH
cord-010604-3d37o05y	88	8	dependent	dependent	JJ
cord-010604-3d37o05y	88	9	kinase	kinase	NN
cord-010604-3d37o05y	88	10	5	5	CD
cord-010604-3d37o05y	88	11	(	(	-LRB-
cord-010604-3d37o05y	88	12	CDK5	CDK5	NNP
cord-010604-3d37o05y	88	13	)	)	-RRB-
cord-010604-3d37o05y	88	14	and	and	CC
cord-010604-3d37o05y	89	1	furthermore	furthermore	RB
cord-010604-3d37o05y	89	2	associates	associate	VBZ
cord-010604-3d37o05y	89	3	with	with	IN
cord-010604-3d37o05y	89	4	the	the	DT
cord-010604-3d37o05y	89	5	three	three	CD
cord-010604-3d37o05y	89	6	subunits	subunit	NNS
cord-010604-3d37o05y	89	7	of	of	IN
cord-010604-3d37o05y	89	8	the	the	DT
cord-010604-3d37o05y	89	9	phosphatase	phosphatase	NN
cord-010604-3d37o05y	90	1	PP2A	PP2A	NNS
cord-010604-3d37o05y	91	1	[	[	-LRB-
cord-010604-3d37o05y	91	2	67	67	CD
cord-010604-3d37o05y	91	3	]	]	-RRB-
cord-010604-3d37o05y	92	1	(	(	-LRB-
cord-010604-3d37o05y	92	2	Figure	figure	NN
cord-010604-3d37o05y	92	3	1B	1b	CD
cord-010604-3d37o05y	92	4	)	)	-RRB-
cord-010604-3d37o05y	92	5	,	,	,
cord-010604-3d37o05y	92	6	which	which	WDT
cord-010604-3d37o05y	92	7	acts	act	VBZ
cord-010604-3d37o05y	92	8	in	in	IN
cord-010604-3d37o05y	92	9	concert	concert	NN
cord-010604-3d37o05y	92	10	with	with	IN
cord-010604-3d37o05y	92	11	CDK5	CDK5	NNP
cord-010604-3d37o05y	92	12	to	to	TO
cord-010604-3d37o05y	92	13	regulate	regulate	VB
cord-010604-3d37o05y	92	14	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	92	15	affecting	affect	VBG
cord-010604-3d37o05y	92	16	downstream	downstream	JJ
cord-010604-3d37o05y	92	17	targets	target	NNS
cord-010604-3d37o05y	92	18	[	[	-LRB-
cord-010604-3d37o05y	92	19	68	68	CD
cord-010604-3d37o05y	92	20	]	]	-RRB-
cord-010604-3d37o05y	92	21	.	.	.
cord-010604-3d37o05y	93	1	Thus	thus	RB
cord-010604-3d37o05y	93	2	,	,	,
cord-010604-3d37o05y	93	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	93	4	redefines	redefine	VBZ
cord-010604-3d37o05y	93	5	signaling	signal	VBG
cord-010604-3d37o05y	93	6	pathway	pathway	NN
cord-010604-3d37o05y	93	7	connections	connection	NNS
cord-010604-3d37o05y	93	8	through	through	IN
cord-010604-3d37o05y	93	9	protein	protein	NN
cord-010604-3d37o05y	93	10	associations	association	NNS
cord-010604-3d37o05y	93	11	.	.	.
cord-010604-3d37o05y	94	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	94	2	's	's	POS
cord-010604-3d37o05y	94	3	impact	impact	NN
cord-010604-3d37o05y	94	4	on	on	IN
cord-010604-3d37o05y	94	5	protein	protein	NN
cord-010604-3d37o05y	94	6	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	94	7	furthermore	furthermore	RB
cord-010604-3d37o05y	94	8	provides	provide	VBZ
cord-010604-3d37o05y	94	9	a	a	DT
cord-010604-3d37o05y	94	10	link	link	NN
cord-010604-3d37o05y	94	11	to	to	IN
cord-010604-3d37o05y	94	12	epigenetic	epigenetic	JJ
cord-010604-3d37o05y	94	13	regulation	regulation	NN
cord-010604-3d37o05y	94	14	as	as	RB
cord-010604-3d37o05y	94	15	well	well	RB
cord-010604-3d37o05y	94	16	as	as	IN
cord-010604-3d37o05y	94	17	to	to	IN
cord-010604-3d37o05y	94	18	metabolic	metabolic	JJ
cord-010604-3d37o05y	94	19	function	function	NN
cord-010604-3d37o05y	94	20	.	.	.
cord-010604-3d37o05y	95	1	The	the	DT
cord-010604-3d37o05y	95	2	link	link	NN
cord-010604-3d37o05y	95	3	to	to	IN
cord-010604-3d37o05y	95	4	epigenetics	epigenetics	NN
cord-010604-3d37o05y	95	5	is	be	VBZ
cord-010604-3d37o05y	95	6	evidenced	evidence	VBN
cord-010604-3d37o05y	95	7	by	by	IN
cord-010604-3d37o05y	95	8	its	-PRON-	PRP$
cord-010604-3d37o05y	95	9	impact	impact	NN
cord-010604-3d37o05y	95	10	on	on	IN
cord-010604-3d37o05y	95	11	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	95	12	,	,	,
cord-010604-3d37o05y	95	13	and	and	CC
cord-010604-3d37o05y	95	14	thus	thus	RB
cord-010604-3d37o05y	95	15	the	the	DT
cord-010604-3d37o05y	95	16	activity	activity	NN
cord-010604-3d37o05y	95	17	of	of	IN
cord-010604-3d37o05y	95	18	DNA	dna	NN
cord-010604-3d37o05y	95	19	methyltransferase	methyltransferase	NN
cord-010604-3d37o05y	95	20	1	1	CD
cord-010604-3d37o05y	95	21	(	(	-LRB-
cord-010604-3d37o05y	95	22	DNMT1	DNMT1	NNP
cord-010604-3d37o05y	95	23	)	)	-RRB-
cord-010604-3d37o05y	95	24	[	[	-LRB-
cord-010604-3d37o05y	95	25	69	69	CD
cord-010604-3d37o05y	95	26	]	]	-RRB-
cord-010604-3d37o05y	95	27	.	.	.
cord-010604-3d37o05y	96	1	Mechanistically	Mechanistically	NNP
cord-010604-3d37o05y	96	2	,	,	,
cord-010604-3d37o05y	96	3	this	this	DT
cord-010604-3d37o05y	96	4	effect	effect	NN
cord-010604-3d37o05y	96	5	appears	appear	VBZ
cord-010604-3d37o05y	96	6	to	to	TO
cord-010604-3d37o05y	96	7	be	be	VB
cord-010604-3d37o05y	96	8	achieved	achieve	VBN
cord-010604-3d37o05y	96	9	through	through	IN
cord-010604-3d37o05y	96	10	the	the	DT
cord-010604-3d37o05y	96	11	differential	differential	JJ
cord-010604-3d37o05y	96	12	association	association	NN
cord-010604-3d37o05y	96	13	of	of	IN
cord-010604-3d37o05y	96	14	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	96	15	and	and	CC
cord-010604-3d37o05y	96	16	its	-PRON-	PRP$
cord-010604-3d37o05y	96	17	close	close	JJ
cord-010604-3d37o05y	96	18	homolog	homolog	NN
cord-010604-3d37o05y	96	19	FKBP52	fkbp52	NN
cord-010604-3d37o05y	96	20	with	with	IN
cord-010604-3d37o05y	96	21	CDK5	CDK5	NNP
cord-010604-3d37o05y	96	22	and	and	CC
cord-010604-3d37o05y	96	23	its	-PRON-	PRP$
cord-010604-3d37o05y	96	24	regulatory	regulatory	JJ
cord-010604-3d37o05y	96	25	protein	protein	NN
cord-010604-3d37o05y	96	26	p35	p35	CD
cord-010604-3d37o05y	96	27	[	[	-LRB-
cord-010604-3d37o05y	96	28	69	69	CD
cord-010604-3d37o05y	96	29	]	]	-RRB-
cord-010604-3d37o05y	96	30	.	.	.
cord-010604-3d37o05y	97	1	Metabolic	metabolic	JJ
cord-010604-3d37o05y	97	2	function	function	NN
cord-010604-3d37o05y	97	3	is	be	VBZ
cord-010604-3d37o05y	97	4	impacted	impact	VBN
cord-010604-3d37o05y	97	5	by	by	IN
cord-010604-3d37o05y	97	6	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	97	7	through	through	IN
cord-010604-3d37o05y	97	8	protein	protein	NN
cord-010604-3d37o05y	97	9	associations	association	NNS
cord-010604-3d37o05y	97	10	that	that	WDT
cord-010604-3d37o05y	97	11	dephosphorylate	dephosphorylate	VBP
cord-010604-3d37o05y	97	12	and	and	CC
cord-010604-3d37o05y	97	13	thus	thus	RB
cord-010604-3d37o05y	97	14	inhibit	inhibit	VB
cord-010604-3d37o05y	97	15	Akt2	Akt2	NNP
cord-010604-3d37o05y	97	16	,	,	,
cord-010604-3d37o05y	97	17	leading	lead	VBG
cord-010604-3d37o05y	97	18	to	to	IN
cord-010604-3d37o05y	97	19	dephosphorylation	dephosphorylation	NN
cord-010604-3d37o05y	97	20	and	and	CC
cord-010604-3d37o05y	97	21	thus	thus	RB
cord-010604-3d37o05y	97	22	inhibition	inhibition	NN
cord-010604-3d37o05y	97	23	of	of	IN
cord-010604-3d37o05y	97	24	AS160	as160	NN
cord-010604-3d37o05y	97	25	and	and	CC
cord-010604-3d37o05y	97	26	reduced	reduce	VBN
cord-010604-3d37o05y	97	27	glucose	glucose	NN
cord-010604-3d37o05y	97	28	uptake	uptake	NN
cord-010604-3d37o05y	97	29	[	[	-LRB-
cord-010604-3d37o05y	97	30	70	70	CD
cord-010604-3d37o05y	97	31	]	]	-RRB-
cord-010604-3d37o05y	97	32	.	.	.
cord-010604-3d37o05y	98	1	PTMs	ptm	NNS
cord-010604-3d37o05y	98	2	are	be	VBP
cord-010604-3d37o05y	98	3	also	also	RB
cord-010604-3d37o05y	98	4	involved	involve	VBN
cord-010604-3d37o05y	98	5	in	in	IN
cord-010604-3d37o05y	98	6	the	the	DT
cord-010604-3d37o05y	98	7	effect	effect	NN
cord-010604-3d37o05y	98	8	of	of	IN
cord-010604-3d37o05y	98	9	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	98	10	on	on	IN
cord-010604-3d37o05y	98	11	microtubule	microtubule	JJ
cord-010604-3d37o05y	98	12	dynamics	dynamic	NNS
cord-010604-3d37o05y	98	13	.	.	.
cord-010604-3d37o05y	99	1	It	-PRON-	PRP
cord-010604-3d37o05y	99	2	is	be	VBZ
cord-010604-3d37o05y	99	3	assumed	assume	VBN
cord-010604-3d37o05y	99	4	that	that	IN
cord-010604-3d37o05y	99	5	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	99	6	of	of	IN
cord-010604-3d37o05y	99	7	tau	tau	NN
cord-010604-3d37o05y	99	8	leads	lead	VBZ
cord-010604-3d37o05y	99	9	to	to	IN
cord-010604-3d37o05y	99	10	its	-PRON-	PRP$
cord-010604-3d37o05y	99	11	dissociation	dissociation	NN
cord-010604-3d37o05y	99	12	from	from	IN
cord-010604-3d37o05y	99	13	microtubules	microtubule	NNS
cord-010604-3d37o05y	99	14	and	and	CC
cord-010604-3d37o05y	99	15	adoption	adoption	NN
cord-010604-3d37o05y	99	16	of	of	IN
cord-010604-3d37o05y	99	17	the	the	DT
cord-010604-3d37o05y	99	18	trans	trans	NNP
cord-010604-3d37o05y	99	19	configuration	configuration	NN
cord-010604-3d37o05y	99	20	of	of	IN
cord-010604-3d37o05y	99	21	specific	specific	JJ
cord-010604-3d37o05y	99	22	peptidylprolyl	peptidylprolyl	JJ
cord-010604-3d37o05y	99	23	bonds	bond	NNS
cord-010604-3d37o05y	99	24	,	,	,
cord-010604-3d37o05y	99	25	while	while	IN
cord-010604-3d37o05y	99	26	the	the	DT
cord-010604-3d37o05y	99	27	association	association	NN
cord-010604-3d37o05y	99	28	of	of	IN
cord-010604-3d37o05y	99	29	phosphorylated	phosphorylated	JJ
cord-010604-3d37o05y	99	30	tau	tau	NNP
cord-010604-3d37o05y	99	31	with	with	IN
cord-010604-3d37o05y	99	32	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	99	33	promotes	promote	VBZ
cord-010604-3d37o05y	99	34	its	-PRON-	PRP$
cord-010604-3d37o05y	99	35	dephosphorylation	dephosphorylation	NN
cord-010604-3d37o05y	99	36	and	and	CC
cord-010604-3d37o05y	99	37	cis	cis	NNP
cord-010604-3d37o05y	99	38	configuration	configuration	NN
cord-010604-3d37o05y	99	39	that	that	WDT
cord-010604-3d37o05y	99	40	is	be	VBZ
cord-010604-3d37o05y	99	41	required	require	VBN
cord-010604-3d37o05y	99	42	for	for	IN
cord-010604-3d37o05y	99	43	microtubule	microtubule	NNP
cord-010604-3d37o05y	99	44	association	association	NNP
cord-010604-3d37o05y	99	45	[	[	-LRB-
cord-010604-3d37o05y	99	46	71	71	CD
cord-010604-3d37o05y	99	47	]	]	-RRB-
cord-010604-3d37o05y	99	48	[	[	-LRB-
cord-010604-3d37o05y	99	49	72	72	CD
cord-010604-3d37o05y	99	50	]	]	-RRB-
cord-010604-3d37o05y	99	51	[	[	-LRB-
cord-010604-3d37o05y	99	52	73	73	CD
cord-010604-3d37o05y	99	53	]	]	-RRB-
cord-010604-3d37o05y	99	54	.	.	.
cord-010604-3d37o05y	100	1	Another	another	DT
cord-010604-3d37o05y	100	2	mass	mass	NN
cord-010604-3d37o05y	100	3	spectrometry	spectrometry	NN
cord-010604-3d37o05y	100	4	-	-	HYPH
cord-010604-3d37o05y	100	5	based	base	VBN
cord-010604-3d37o05y	100	6	screen	screen	NN
cord-010604-3d37o05y	100	7	for	for	IN
cord-010604-3d37o05y	100	8	FKBP51-associated	fkbp51-associate	VBN
cord-010604-3d37o05y	100	9	proteins	protein	NNS
cord-010604-3d37o05y	100	10	revealed	reveal	VBD
cord-010604-3d37o05y	100	11	the	the	DT
cord-010604-3d37o05y	100	12	Rho	Rho	NNP
cord-010604-3d37o05y	100	13	(	(	-LRB-
cord-010604-3d37o05y	100	14	Ras	Ras	NNP
cord-010604-3d37o05y	100	15	homologous	homologous	NNP
cord-010604-3d37o05y	100	16	)	)	-RRB-
cord-010604-3d37o05y	101	1	GTPase	gtpase	LS
cord-010604-3d37o05y	101	2	-	-	HYPH
cord-010604-3d37o05y	101	3	activating	activate	VBG
cord-010604-3d37o05y	101	4	proteins	protein	NNS
cord-010604-3d37o05y	101	5	deleted	delete	VBN
cord-010604-3d37o05y	101	6	in	in	IN
cord-010604-3d37o05y	101	7	liver	liver	NN
cord-010604-3d37o05y	101	8	cancer	cancer	NN
cord-010604-3d37o05y	101	9	(	(	-LRB-
cord-010604-3d37o05y	101	10	DLC	DLC	NNP
cord-010604-3d37o05y	101	11	)	)	-RRB-
cord-010604-3d37o05y	101	12	1	1	CD
cord-010604-3d37o05y	101	13	and	and	CC
cord-010604-3d37o05y	101	14	DLC2	DLC2	NNP
cord-010604-3d37o05y	101	15	as	as	IN
cord-010604-3d37o05y	101	16	novel	novel	NN
cord-010604-3d37o05y	101	17	interaction	interaction	NN
cord-010604-3d37o05y	101	18	partners	partner	NNS
cord-010604-3d37o05y	101	19	[	[	-LRB-
cord-010604-3d37o05y	101	20	74	74	CD
cord-010604-3d37o05y	101	21	]	]	-RRB-
cord-010604-3d37o05y	101	22	.	.	.
cord-010604-3d37o05y	102	1	Accordingly	accordingly	RB
cord-010604-3d37o05y	102	2	,	,	,
cord-010604-3d37o05y	102	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	102	4	enhances	enhance	VBZ
cord-010604-3d37o05y	102	5	RhoA	RhoA	NNP
cord-010604-3d37o05y	102	6	activity	activity	NN
cord-010604-3d37o05y	102	7	and	and	CC
cord-010604-3d37o05y	102	8	signaling	signal	VBG
cord-010604-3d37o05y	102	9	through	through	IN
cord-010604-3d37o05y	102	10	the	the	DT
cord-010604-3d37o05y	102	11	serine	serine	NN
cord-010604-3d37o05y	102	12	/	/	SYM
cord-010604-3d37o05y	102	13	threonine	threonine	NN
cord-010604-3d37o05y	102	14	kinase	kinase	NNP
cord-010604-3d37o05y	102	15	ROCK	ROCK	NNP
cord-010604-3d37o05y	102	16	(	(	-LRB-
cord-010604-3d37o05y	102	17	rho	rho	NN
cord-010604-3d37o05y	102	18	-	-	HYPH
cord-010604-3d37o05y	102	19	associated	associate	VBN
cord-010604-3d37o05y	102	20	coiled	coil	VBN
cord-010604-3d37o05y	102	21	-	-	HYPH
cord-010604-3d37o05y	102	22	coil	coil	NN
cord-010604-3d37o05y	102	23	containing	contain	VBG
cord-010604-3d37o05y	102	24	protein	protein	NN
cord-010604-3d37o05y	102	25	kinase	kinase	NN
cord-010604-3d37o05y	102	26	)	)	-RRB-
cord-010604-3d37o05y	102	27	along	along	IN
cord-010604-3d37o05y	102	28	with	with	IN
cord-010604-3d37o05y	102	29	the	the	DT
cord-010604-3d37o05y	102	30	linked	link	VBN
cord-010604-3d37o05y	102	31	processes	process	NNS
cord-010604-3d37o05y	102	32	cell	cell	NN
cord-010604-3d37o05y	102	33	migration	migration	NN
cord-010604-3d37o05y	102	34	and	and	CC
cord-010604-3d37o05y	102	35	invasion	invasion	NN
cord-010604-3d37o05y	102	36	[	[	-LRB-
cord-010604-3d37o05y	102	37	74	74	CD
cord-010604-3d37o05y	102	38	]	]	-RRB-
cord-010604-3d37o05y	102	39	.	.	.
cord-010604-3d37o05y	103	1	The	the	DT
cord-010604-3d37o05y	103	2	exact	exact	JJ
cord-010604-3d37o05y	103	3	mechanism	mechanism	NN
cord-010604-3d37o05y	103	4	remains	remain	VBZ
cord-010604-3d37o05y	103	5	to	to	TO
cord-010604-3d37o05y	103	6	be	be	VB
cord-010604-3d37o05y	103	7	elucidated	elucidate	VBN
cord-010604-3d37o05y	103	8	.	.	.
cord-010604-3d37o05y	104	1	It	-PRON-	PRP
cord-010604-3d37o05y	104	2	appears	appear	VBZ
cord-010604-3d37o05y	104	3	that	that	IN
cord-010604-3d37o05y	104	4	this	this	DT
cord-010604-3d37o05y	104	5	is	be	VBZ
cord-010604-3d37o05y	104	6	an	an	DT
cord-010604-3d37o05y	104	7	example	example	NN
cord-010604-3d37o05y	104	8	for	for	IN
cord-010604-3d37o05y	104	9	a	a	DT
cord-010604-3d37o05y	104	10	more	more	RBR
cord-010604-3d37o05y	104	11	indirect	indirect	JJ
cord-010604-3d37o05y	104	12	effect	effect	NN
cord-010604-3d37o05y	104	13	of	of	IN
cord-010604-3d37o05y	104	14	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	104	15	on	on	IN
cord-010604-3d37o05y	104	16	the	the	DT
cord-010604-3d37o05y	104	17	phosphoproteome	phosphoproteome	NN
cord-010604-3d37o05y	104	18	:	:	:
cord-010604-3d37o05y	104	19	it	-PRON-	PRP
cord-010604-3d37o05y	104	20	inhibits	inhibit	VBZ
cord-010604-3d37o05y	104	21	a	a	DT
cord-010604-3d37o05y	104	22	protein	protein	NN
cord-010604-3d37o05y	104	23	,	,	,
cord-010604-3d37o05y	104	24	DLC	DLC	NNP
cord-010604-3d37o05y	104	25	,	,	,
cord-010604-3d37o05y	104	26	that	that	WDT
cord-010604-3d37o05y	104	27	serves	serve	VBZ
cord-010604-3d37o05y	104	28	as	as	IN
cord-010604-3d37o05y	104	29	a	a	DT
cord-010604-3d37o05y	104	30	GTPase	GTPase	NNP
cord-010604-3d37o05y	104	31	activator	activator	NN
cord-010604-3d37o05y	104	32	for	for	IN
cord-010604-3d37o05y	104	33	members	member	NNS
cord-010604-3d37o05y	104	34	of	of	IN
cord-010604-3d37o05y	104	35	the	the	DT
cord-010604-3d37o05y	104	36	Rho	Rho	NNP
cord-010604-3d37o05y	104	37	family	family	NN
cord-010604-3d37o05y	104	38	of	of	IN
cord-010604-3d37o05y	104	39	GTPases	gtpase	NNS
cord-010604-3d37o05y	104	40	that	that	WDT
cord-010604-3d37o05y	104	41	regulate	regulate	VBP
cord-010604-3d37o05y	104	42	downstream	downstream	JJ
cord-010604-3d37o05y	104	43	kinases	kinase	NNS
cord-010604-3d37o05y	104	44	[	[	-LRB-
cord-010604-3d37o05y	104	45	74	74	CD
cord-010604-3d37o05y	104	46	,	,	,
cord-010604-3d37o05y	104	47	75	75	CD
cord-010604-3d37o05y	104	48	]	]	-RRB-
cord-010604-3d37o05y	104	49	.	.	.
cord-010604-3d37o05y	105	1	Ubiquitination	Ubiquitination	NNP
cord-010604-3d37o05y	105	2	is	be	VBZ
cord-010604-3d37o05y	105	3	an	an	DT
cord-010604-3d37o05y	105	4	essential	essential	JJ
cord-010604-3d37o05y	105	5	PTM	PTM	NNP
cord-010604-3d37o05y	105	6	in	in	IN
cord-010604-3d37o05y	105	7	all	all	DT
cord-010604-3d37o05y	105	8	eukaryotes	eukaryote	NNS
cord-010604-3d37o05y	105	9	[	[	-LRB-
cord-010604-3d37o05y	105	10	3	3	CD
cord-010604-3d37o05y	105	11	,	,	,
cord-010604-3d37o05y	105	12	76	76	CD
cord-010604-3d37o05y	105	13	]	]	-RRB-
cord-010604-3d37o05y	105	14	.	.	.
cord-010604-3d37o05y	106	1	It	-PRON-	PRP
cord-010604-3d37o05y	106	2	determines	determine	VBZ
cord-010604-3d37o05y	106	3	protein	protein	NN
cord-010604-3d37o05y	106	4	stability	stability	NN
cord-010604-3d37o05y	106	5	as	as	RB
cord-010604-3d37o05y	106	6	well	well	RB
cord-010604-3d37o05y	106	7	as	as	IN
cord-010604-3d37o05y	106	8	protein	protein	NN
cord-010604-3d37o05y	106	9	function	function	NN
cord-010604-3d37o05y	106	10	through	through	IN
cord-010604-3d37o05y	106	11	changing	change	VBG
cord-010604-3d37o05y	106	12	protein	protein	NN
cord-010604-3d37o05y	106	13	-	-	HYPH
cord-010604-3d37o05y	106	14	protein	protein	NN
cord-010604-3d37o05y	106	15	interaction	interaction	NN
cord-010604-3d37o05y	106	16	.	.	.
cord-010604-3d37o05y	107	1	Biochemically	biochemically	RB
cord-010604-3d37o05y	107	2	,	,	,
cord-010604-3d37o05y	107	3	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	107	4	is	be	VBZ
cord-010604-3d37o05y	107	5	a	a	DT
cord-010604-3d37o05y	107	6	process	process	NN
cord-010604-3d37o05y	107	7	where	where	WRB
cord-010604-3d37o05y	107	8	the	the	DT
cord-010604-3d37o05y	107	9	76	76	CD
cord-010604-3d37o05y	107	10	amino	amino	NN
cord-010604-3d37o05y	107	11	acid	acid	NN
cord-010604-3d37o05y	107	12	protein	protein	NN
cord-010604-3d37o05y	107	13	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	107	14	is	be	VBZ
cord-010604-3d37o05y	107	15	covalently	covalently	RB
cord-010604-3d37o05y	107	16	linked	link	VBN
cord-010604-3d37o05y	107	17	to	to	IN
cord-010604-3d37o05y	107	18	other	other	JJ
cord-010604-3d37o05y	107	19	proteins	protein	NNS
cord-010604-3d37o05y	107	20	,	,	,
cord-010604-3d37o05y	107	21	in	in	IN
cord-010604-3d37o05y	107	22	most	most	JJS
cord-010604-3d37o05y	107	23	cases	case	NNS
cord-010604-3d37o05y	107	24	through	through	IN
cord-010604-3d37o05y	107	25	the	the	DT
cord-010604-3d37o05y	107	26	formation	formation	NN
cord-010604-3d37o05y	107	27	of	of	IN
cord-010604-3d37o05y	107	28	an	an	DT
cord-010604-3d37o05y	107	29	amide	amide	NN
cord-010604-3d37o05y	107	30	bond	bond	NN
cord-010604-3d37o05y	107	31	between	between	IN
cord-010604-3d37o05y	107	32	its	-PRON-	PRP$
cord-010604-3d37o05y	107	33	carboxy	carboxy	JJ
cord-010604-3d37o05y	107	34	terminus	terminus	NN
cord-010604-3d37o05y	107	35	and	and	CC
cord-010604-3d37o05y	107	36	the	the	DT
cord-010604-3d37o05y	107	37	ε	ε	NNP
cord-010604-3d37o05y	107	38	amino	amino	NNP
cord-010604-3d37o05y	107	39	group	group	NN
cord-010604-3d37o05y	107	40	of	of	IN
cord-010604-3d37o05y	107	41	lysine	lysine	NN
cord-010604-3d37o05y	107	42	residues	residue	NNS
cord-010604-3d37o05y	107	43	in	in	IN
cord-010604-3d37o05y	107	44	the	the	DT
cord-010604-3d37o05y	107	45	substrate	substrate	NN
cord-010604-3d37o05y	107	46	proteins	protein	NNS
cord-010604-3d37o05y	107	47	[	[	-LRB-
cord-010604-3d37o05y	107	48	34	34	CD
cord-010604-3d37o05y	107	49	,	,	,
cord-010604-3d37o05y	107	50	76	76	CD
cord-010604-3d37o05y	107	51	]	]	-RRB-
cord-010604-3d37o05y	107	52	.	.	.
cord-010604-3d37o05y	108	1	In	in	IN
cord-010604-3d37o05y	108	2	addition	addition	NN
cord-010604-3d37o05y	108	3	to	to	IN
cord-010604-3d37o05y	108	4	this	this	DT
cord-010604-3d37o05y	108	5	isopeptide	isopeptide	NN
cord-010604-3d37o05y	108	6	bond	bond	NN
cord-010604-3d37o05y	108	7	,	,	,
cord-010604-3d37o05y	108	8	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	108	9	forms	form	NNS
cord-010604-3d37o05y	108	10	other	other	JJ
cord-010604-3d37o05y	108	11	links	link	NNS
cord-010604-3d37o05y	108	12	to	to	TO
cord-010604-3d37o05y	108	13	target	target	VB
cord-010604-3d37o05y	108	14	diverse	diverse	JJ
cord-010604-3d37o05y	108	15	protein	protein	NN
cord-010604-3d37o05y	108	16	residues	residue	NNS
cord-010604-3d37o05y	108	17	such	such	JJ
cord-010604-3d37o05y	108	18	as	as	IN
cord-010604-3d37o05y	108	19	cysteines	cysteine	NNS
cord-010604-3d37o05y	108	20	,	,	,
cord-010604-3d37o05y	108	21	serines	serines	NNPS
cord-010604-3d37o05y	108	22	or	or	CC
cord-010604-3d37o05y	108	23	threonines	threonine	NNS
cord-010604-3d37o05y	108	24	[	[	-LRB-
cord-010604-3d37o05y	108	25	3	3	CD
cord-010604-3d37o05y	108	26	]	]	-RRB-
cord-010604-3d37o05y	108	27	.	.	.
cord-010604-3d37o05y	109	1	Ubiquitination	Ubiquitination	NNP
cord-010604-3d37o05y	109	2	comes	come	VBZ
cord-010604-3d37o05y	109	3	in	in	IN
cord-010604-3d37o05y	109	4	the	the	DT
cord-010604-3d37o05y	109	5	form	form	NN
cord-010604-3d37o05y	109	6	of	of	IN
cord-010604-3d37o05y	109	7	mono	mono	NN
cord-010604-3d37o05y	109	8	-	-	HYPH
cord-010604-3d37o05y	109	9	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	109	10	and	and	CC
cord-010604-3d37o05y	109	11	polyubiquitination	polyubiquitination	NN
cord-010604-3d37o05y	109	12	,	,	,
cord-010604-3d37o05y	109	13	where	where	WRB
cord-010604-3d37o05y	109	14	distinct	distinct	JJ
cord-010604-3d37o05y	109	15	lysines	lysine	NNS
cord-010604-3d37o05y	109	16	of	of	IN
cord-010604-3d37o05y	109	17	one	one	CD
cord-010604-3d37o05y	109	18	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	109	19	serve	serve	NN
cord-010604-3d37o05y	109	20	as	as	IN
cord-010604-3d37o05y	109	21	attachment	attachment	NN
cord-010604-3d37o05y	109	22	sites	site	NNS
cord-010604-3d37o05y	109	23	for	for	IN
cord-010604-3d37o05y	109	24	additional	additional	JJ
cord-010604-3d37o05y	109	25	ubiquitin	ubiquitin	JJ
cord-010604-3d37o05y	109	26	moieties	moiety	NNS
cord-010604-3d37o05y	109	27	.	.	.
cord-010604-3d37o05y	110	1	The	the	DT
cord-010604-3d37o05y	110	2	site	site	NN
cord-010604-3d37o05y	110	3	of	of	IN
cord-010604-3d37o05y	110	4	linkage	linkage	NN
cord-010604-3d37o05y	110	5	destines	destine	VBZ
cord-010604-3d37o05y	110	6	the	the	DT
cord-010604-3d37o05y	110	7	modified	modify	VBN
cord-010604-3d37o05y	110	8	protein	protein	NN
cord-010604-3d37o05y	110	9	to	to	IN
cord-010604-3d37o05y	110	10	different	different	JJ
cord-010604-3d37o05y	110	11	functions	function	NNS
cord-010604-3d37o05y	110	12	.	.	.
cord-010604-3d37o05y	111	1	For	for	IN
cord-010604-3d37o05y	111	2	example	example	NN
cord-010604-3d37o05y	111	3	,	,	,
cord-010604-3d37o05y	111	4	poly	poly	NN
cord-010604-3d37o05y	111	5	-	-	HYPH
cord-010604-3d37o05y	111	6	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	111	7	through	through	IN
cord-010604-3d37o05y	111	8	the	the	DT
cord-010604-3d37o05y	111	9	lysines	lysine	NNS
cord-010604-3d37o05y	111	10	at	at	IN
cord-010604-3d37o05y	111	11	position	position	NN
cord-010604-3d37o05y	111	12	11	11	CD
cord-010604-3d37o05y	111	13	and	and	CC
cord-010604-3d37o05y	111	14	48	48	CD
cord-010604-3d37o05y	111	15	typically	typically	RB
cord-010604-3d37o05y	111	16	lead	lead	VBP
cord-010604-3d37o05y	111	17	to	to	IN
cord-010604-3d37o05y	111	18	degradation	degradation	NN
cord-010604-3d37o05y	111	19	of	of	IN
cord-010604-3d37o05y	111	20	the	the	DT
cord-010604-3d37o05y	111	21	protein	protein	NN
cord-010604-3d37o05y	111	22	through	through	IN
cord-010604-3d37o05y	111	23	the	the	DT
cord-010604-3d37o05y	111	24	26S	26S	NNP
cord-010604-3d37o05y	111	25	proteasome	proteasome	NN
cord-010604-3d37o05y	111	26	[	[	-LRB-
cord-010604-3d37o05y	111	27	77	77	CD
cord-010604-3d37o05y	111	28	,	,	,
cord-010604-3d37o05y	111	29	78	78	CD
cord-010604-3d37o05y	111	30	]	]	-RRB-
cord-010604-3d37o05y	111	31	.	.	.
cord-010604-3d37o05y	112	1	The	the	DT
cord-010604-3d37o05y	112	2	first	first	JJ
cord-010604-3d37o05y	112	3	indication	indication	NN
cord-010604-3d37o05y	112	4	that	that	IN
cord-010604-3d37o05y	112	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	112	6	influences	influence	VBZ
cord-010604-3d37o05y	112	7	the	the	DT
cord-010604-3d37o05y	112	8	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	112	9	of	of	IN
cord-010604-3d37o05y	112	10	other	other	JJ
cord-010604-3d37o05y	112	11	proteins	protein	NNS
cord-010604-3d37o05y	112	12	came	come	VBD
cord-010604-3d37o05y	112	13	from	from	IN
cord-010604-3d37o05y	112	14	the	the	DT
cord-010604-3d37o05y	112	15	observation	observation	NN
cord-010604-3d37o05y	112	16	that	that	IN
cord-010604-3d37o05y	112	17	it	-PRON-	PRP
cord-010604-3d37o05y	112	18	stabilizes	stabilize	VBZ
cord-010604-3d37o05y	112	19	tau	tau	NN
cord-010604-3d37o05y	112	20	and	and	CC
cord-010604-3d37o05y	112	21	protects	protect	VBZ
cord-010604-3d37o05y	112	22	it	-PRON-	PRP
cord-010604-3d37o05y	112	23	from	from	IN
cord-010604-3d37o05y	112	24	becoming	become	VBG
cord-010604-3d37o05y	112	25	ubiquitinated	ubiquitinated	JJ
cord-010604-3d37o05y	112	26	[	[	-LRB-
cord-010604-3d37o05y	112	27	71	71	CD
cord-010604-3d37o05y	112	28	]	]	-RRB-
cord-010604-3d37o05y	112	29	.	.	.
cord-010604-3d37o05y	113	1	The	the	DT
cord-010604-3d37o05y	113	2	mode	mode	NN
cord-010604-3d37o05y	113	3	of	of	IN
cord-010604-3d37o05y	113	4	action	action	NN
cord-010604-3d37o05y	113	5	appears	appear	VBZ
cord-010604-3d37o05y	113	6	to	to	TO
cord-010604-3d37o05y	113	7	be	be	VB
cord-010604-3d37o05y	113	8	an	an	DT
cord-010604-3d37o05y	113	9	indirect	indirect	JJ
cord-010604-3d37o05y	113	10	mechanism	mechanism	NN
cord-010604-3d37o05y	113	11	where	where	WRB
cord-010604-3d37o05y	113	12	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	113	13	influences	influence	VBZ
cord-010604-3d37o05y	113	14	the	the	DT
cord-010604-3d37o05y	113	15	conformation	conformation	NN
cord-010604-3d37o05y	113	16	and/or	and/or	CC
cord-010604-3d37o05y	113	17	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	113	18	of	of	IN
cord-010604-3d37o05y	113	19	tau	tau	NN
cord-010604-3d37o05y	113	20	to	to	TO
cord-010604-3d37o05y	113	21	prevent	prevent	VB
cord-010604-3d37o05y	113	22	the	the	DT
cord-010604-3d37o05y	113	23	access	access	NN
cord-010604-3d37o05y	113	24	of	of	IN
cord-010604-3d37o05y	113	25	ubiquitinating	ubiquitinate	VBG
cord-010604-3d37o05y	113	26	enzymes	enzyme	NNS
cord-010604-3d37o05y	113	27	[	[	-LRB-
cord-010604-3d37o05y	113	28	71	71	CD
cord-010604-3d37o05y	113	29	,	,	,
cord-010604-3d37o05y	113	30	73	73	CD
cord-010604-3d37o05y	113	31	,	,	,
cord-010604-3d37o05y	113	32	79	79	CD
cord-010604-3d37o05y	113	33	]	]	-RRB-
cord-010604-3d37o05y	113	34	.	.	.
cord-010604-3d37o05y	114	1	For	for	IN
cord-010604-3d37o05y	114	2	the	the	DT
cord-010604-3d37o05y	114	3	differential	differential	JJ
cord-010604-3d37o05y	114	4	effect	effect	NN
cord-010604-3d37o05y	114	5	of	of	IN
cord-010604-3d37o05y	114	6	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	114	7	and	and	CC
cord-010604-3d37o05y	114	8	FKBP52	FKBP52	NNS
cord-010604-3d37o05y	114	9	on	on	IN
cord-010604-3d37o05y	114	10	NFκB	NFκB	NNP
cord-010604-3d37o05y	114	11	,	,	,
cord-010604-3d37o05y	114	12	it	-PRON-	PRP
cord-010604-3d37o05y	114	13	has	have	VBZ
cord-010604-3d37o05y	114	14	been	be	VBN
cord-010604-3d37o05y	114	15	proposed	propose	VBN
cord-010604-3d37o05y	114	16	that	that	IN
cord-010604-3d37o05y	114	17	a	a	DT
cord-010604-3d37o05y	114	18	mechanism	mechanism	NN
cord-010604-3d37o05y	114	19	is	be	VBZ
cord-010604-3d37o05y	114	20	involved	involve	VBN
cord-010604-3d37o05y	114	21	that	that	WDT
cord-010604-3d37o05y	114	22	is	be	VBZ
cord-010604-3d37o05y	114	23	similar	similar	JJ
cord-010604-3d37o05y	114	24	to	to	IN
cord-010604-3d37o05y	114	25	Pin1	Pin1	NNP
cord-010604-3d37o05y	114	26	's	's	POS
cord-010604-3d37o05y	114	27	promotion	promotion	NN
cord-010604-3d37o05y	114	28	of	of	IN
cord-010604-3d37o05y	114	29	the	the	DT
cord-010604-3d37o05y	114	30	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	114	31	-	-	HYPH
cord-010604-3d37o05y	114	32	mediated	mediate	VBN
cord-010604-3d37o05y	114	33	proteolysis	proteolysis	NN
cord-010604-3d37o05y	114	34	of	of	IN
cord-010604-3d37o05y	114	35	the	the	DT
cord-010604-3d37o05y	114	36	NFκB	NFκB	NNP
cord-010604-3d37o05y	114	37	subunit	subunit	NN
cord-010604-3d37o05y	114	38	p65/	p65/	NN
cord-010604-3d37o05y	115	1	RelA	RelA	NNP
cord-010604-3d37o05y	115	2	[	[	-LRB-
cord-010604-3d37o05y	115	3	80	80	CD
cord-010604-3d37o05y	115	4	]	]	-RRB-
cord-010604-3d37o05y	115	5	.	.	.
cord-010604-3d37o05y	116	1	Further	further	JJ
cord-010604-3d37o05y	116	2	experimental	experimental	JJ
cord-010604-3d37o05y	116	3	evidence	evidence	NN
cord-010604-3d37o05y	116	4	is	be	VBZ
cord-010604-3d37o05y	116	5	awaited	await	VBN
cord-010604-3d37o05y	116	6	;	;	:
cord-010604-3d37o05y	116	7	in	in	IN
cord-010604-3d37o05y	116	8	any	any	DT
cord-010604-3d37o05y	116	9	case	case	NN
cord-010604-3d37o05y	116	10	,	,	,
cord-010604-3d37o05y	116	11	this	this	DT
cord-010604-3d37o05y	116	12	effect	effect	NN
cord-010604-3d37o05y	116	13	also	also	RB
cord-010604-3d37o05y	116	14	would	would	MD
cord-010604-3d37o05y	116	15	be	be	VB
cord-010604-3d37o05y	116	16	indirect	indirect	JJ
cord-010604-3d37o05y	116	17	.	.	.
cord-010604-3d37o05y	117	1	The	the	DT
cord-010604-3d37o05y	117	2	reported	reported	JJ
cord-010604-3d37o05y	117	3	effect	effect	NN
cord-010604-3d37o05y	117	4	of	of	IN
cord-010604-3d37o05y	117	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	117	6	on	on	IN
cord-010604-3d37o05y	117	7	NFκB	NFκB	NNP
cord-010604-3d37o05y	117	8	signaling	signal	VBG
cord-010604-3d37o05y	117	9	through	through	IN
cord-010604-3d37o05y	117	10	the	the	DT
cord-010604-3d37o05y	117	11	association	association	NN
cord-010604-3d37o05y	117	12	with	with	IN
cord-010604-3d37o05y	117	13	TRAF2	TRAF2	NNP
cord-010604-3d37o05y	117	14	and	and	CC
cord-010604-3d37o05y	117	15	IKK	IKK	NNP
cord-010604-3d37o05y	117	16	is	be	VBZ
cord-010604-3d37o05y	117	17	dependent	dependent	JJ
cord-010604-3d37o05y	117	18	on	on	IN
cord-010604-3d37o05y	117	19	the	the	DT
cord-010604-3d37o05y	117	20	K63-poly	K63-poly	NNP
cord-010604-3d37o05y	117	21	-	-	HYPH
cord-010604-3d37o05y	117	22	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	117	23	of	of	IN
cord-010604-3d37o05y	117	24	RIP1	RIP1	NNP
cord-010604-3d37o05y	117	25	,	,	,
cord-010604-3d37o05y	117	26	but	but	CC
cord-010604-3d37o05y	117	27	does	do	VBZ
cord-010604-3d37o05y	117	28	not	not	RB
cord-010604-3d37o05y	117	29	appear	appear	VB
cord-010604-3d37o05y	117	30	to	to	TO
cord-010604-3d37o05y	117	31	impact	impact	VB
cord-010604-3d37o05y	117	32	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	117	33	in	in	IN
cord-010604-3d37o05y	117	34	this	this	DT
cord-010604-3d37o05y	117	35	context	context	NN
cord-010604-3d37o05y	117	36	[	[	-LRB-
cord-010604-3d37o05y	117	37	52	52	CD
cord-010604-3d37o05y	117	38	]	]	-RRB-
cord-010604-3d37o05y	117	39	.	.	.
cord-010604-3d37o05y	118	1	The	the	DT
cord-010604-3d37o05y	118	2	E3	e3	NN
cord-010604-3d37o05y	118	3	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	118	4	-	-	HYPH
cord-010604-3d37o05y	118	5	protein	protein	NN
cord-010604-3d37o05y	118	6	ligase	ligase	NN
cord-010604-3d37o05y	118	7	complex	complex	JJ
cord-010604-3d37o05y	118	8	members	member	NNS
cord-010604-3d37o05y	119	1	TRAF3	TRAF3	NNP
cord-010604-3d37o05y	119	2	and	and	CC
cord-010604-3d37o05y	119	3	TRAF6	TRAF6	NNP
cord-010604-3d37o05y	119	4	also	also	RB
cord-010604-3d37o05y	119	5	were	be	VBD
cord-010604-3d37o05y	119	6	discovered	discover	VBN
cord-010604-3d37o05y	119	7	as	as	IN
cord-010604-3d37o05y	119	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	119	9	associating	associate	VBG
cord-010604-3d37o05y	119	10	proteins	protein	NNS
cord-010604-3d37o05y	119	11	,	,	,
cord-010604-3d37o05y	119	12	with	with	IN
cord-010604-3d37o05y	119	13	currently	currently	RB
cord-010604-3d37o05y	119	14	unknown	unknown	JJ
cord-010604-3d37o05y	119	15	consequences	consequence	NNS
cord-010604-3d37o05y	119	16	for	for	IN
cord-010604-3d37o05y	119	17	their	-PRON-	PRP$
cord-010604-3d37o05y	119	18	enzymatic	enzymatic	JJ
cord-010604-3d37o05y	119	19	activity	activity	NN
cord-010604-3d37o05y	119	20	[	[	-LRB-
cord-010604-3d37o05y	119	21	81	81	CD
cord-010604-3d37o05y	119	22	]	]	-RRB-
cord-010604-3d37o05y	119	23	.	.	.
cord-010604-3d37o05y	120	1	More	more	RBR
cord-010604-3d37o05y	120	2	recently	recently	RB
cord-010604-3d37o05y	120	3	,	,	,
cord-010604-3d37o05y	120	4	a	a	DT
cord-010604-3d37o05y	120	5	direct	direct	JJ
cord-010604-3d37o05y	120	6	association	association	NN
cord-010604-3d37o05y	120	7	of	of	IN
cord-010604-3d37o05y	120	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	120	9	with	with	IN
cord-010604-3d37o05y	120	10	Glomulin	Glomulin	NNP
cord-010604-3d37o05y	120	11	,	,	,
cord-010604-3d37o05y	120	12	a	a	DT
cord-010604-3d37o05y	120	13	regulator	regulator	NN
cord-010604-3d37o05y	120	14	of	of	IN
cord-010604-3d37o05y	120	15	the	the	DT
cord-010604-3d37o05y	120	16	SCF	SCF	NNP
cord-010604-3d37o05y	120	17	(	(	-LRB-
cord-010604-3d37o05y	120	18	Skp1-CUL1-F	Skp1-CUL1-F	NNP
cord-010604-3d37o05y	120	19	-	-	HYPH
cord-010604-3d37o05y	120	20	box	box	NN
cord-010604-3d37o05y	120	21	protein	protein	NN
cord-010604-3d37o05y	120	22	)	)	-RRB-
cord-010604-3d37o05y	120	23	E3	E3	NNP
cord-010604-3d37o05y	120	24	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	120	25	-	-	HYPH
cord-010604-3d37o05y	120	26	protein	protein	NN
cord-010604-3d37o05y	120	27	ligase	ligase	NN
cord-010604-3d37o05y	120	28	complex	complex	NN
cord-010604-3d37o05y	120	29	,	,	,
cord-010604-3d37o05y	120	30	has	have	VBZ
cord-010604-3d37o05y	120	31	been	be	VBN
cord-010604-3d37o05y	120	32	described	describe	VBN
cord-010604-3d37o05y	120	33	in	in	IN
cord-010604-3d37o05y	120	34	detail	detail	NN
cord-010604-3d37o05y	120	35	and	and	CC
cord-010604-3d37o05y	120	36	in	in	IN
cord-010604-3d37o05y	120	37	comparison	comparison	NN
cord-010604-3d37o05y	120	38	with	with	IN
cord-010604-3d37o05y	120	39	other	other	JJ
cord-010604-3d37o05y	120	40	FKBPs	fkbp	NNS
cord-010604-3d37o05y	120	41	[	[	-LRB-
cord-010604-3d37o05y	120	42	82	82	CD
cord-010604-3d37o05y	120	43	]	]	-RRB-
cord-010604-3d37o05y	120	44	.	.	.
cord-010604-3d37o05y	121	1	It	-PRON-	PRP
cord-010604-3d37o05y	121	2	is	be	VBZ
cord-010604-3d37o05y	121	3	likely	likely	JJ
cord-010604-3d37o05y	121	4	that	that	IN
cord-010604-3d37o05y	121	5	this	this	DT
cord-010604-3d37o05y	121	6	interaction	interaction	NN
cord-010604-3d37o05y	121	7	affects	affect	VBZ
cord-010604-3d37o05y	121	8	the	the	DT
cord-010604-3d37o05y	121	9	ubiquitination	ubiquitination	JJ
cord-010604-3d37o05y	121	10	activity	activity	NN
cord-010604-3d37o05y	121	11	of	of	IN
cord-010604-3d37o05y	121	12	SCF	SCF	NNP
cord-010604-3d37o05y	121	13	;	;	:
cord-010604-3d37o05y	121	14	experimental	experimental	JJ
cord-010604-3d37o05y	121	15	investigation	investigation	NN
cord-010604-3d37o05y	121	16	of	of	IN
cord-010604-3d37o05y	121	17	this	this	DT
cord-010604-3d37o05y	121	18	potential	potential	JJ
cord-010604-3d37o05y	121	19	impact	impact	NN
cord-010604-3d37o05y	121	20	of	of	IN
cord-010604-3d37o05y	121	21	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	121	22	on	on	IN
cord-010604-3d37o05y	121	23	the	the	DT
cord-010604-3d37o05y	121	24	ubiquitination	ubiquitination	NNP
cord-010604-3d37o05y	121	25	machinery	machinery	NN
cord-010604-3d37o05y	121	26	has	have	VBZ
cord-010604-3d37o05y	121	27	not	not	RB
cord-010604-3d37o05y	121	28	been	be	VBN
cord-010604-3d37o05y	121	29	reported	report	VBN
cord-010604-3d37o05y	121	30	yet	yet	RB
cord-010604-3d37o05y	121	31	.	.	.
cord-010604-3d37o05y	122	1	A	a	DT
cord-010604-3d37o05y	122	2	yeast	yeast	NN
cord-010604-3d37o05y	122	3	two	two	CD
cord-010604-3d37o05y	122	4	-	-	HYPH
cord-010604-3d37o05y	122	5	hybrid	hybrid	NN
cord-010604-3d37o05y	122	6	screen	screen	NN
cord-010604-3d37o05y	122	7	indicated	indicate	VBD
cord-010604-3d37o05y	122	8	protein	protein	NN
cord-010604-3d37o05y	122	9	associations	association	NNS
cord-010604-3d37o05y	122	10	of	of	IN
cord-010604-3d37o05y	122	11	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	122	12	with	with	IN
cord-010604-3d37o05y	122	13	the	the	DT
cord-010604-3d37o05y	122	14	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	122	15	-	-	HYPH
cord-010604-3d37o05y	122	16	specific	specific	JJ
cord-010604-3d37o05y	122	17	peptidases	peptidase	NNS
cord-010604-3d37o05y	122	18	(	(	-LRB-
cord-010604-3d37o05y	122	19	USPs	USPs	NNP
cord-010604-3d37o05y	122	20	)	)	-RRB-
cord-010604-3d37o05y	122	21	18	18	CD
cord-010604-3d37o05y	122	22	,	,	,
cord-010604-3d37o05y	122	23	36	36	CD
cord-010604-3d37o05y	122	24	and	and	CC
cord-010604-3d37o05y	122	25	49	49	CD
cord-010604-3d37o05y	122	26	as	as	RB
cord-010604-3d37o05y	122	27	well	well	RB
cord-010604-3d37o05y	122	28	as	as	IN
cord-010604-3d37o05y	122	29	with	with	IN
cord-010604-3d37o05y	122	30	the	the	DT
cord-010604-3d37o05y	122	31	E3	e3	NN
cord-010604-3d37o05y	122	32	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	122	33	ligases	ligase	NNS
cord-010604-3d37o05y	122	34	RING	ring	VBP
cord-010604-3d37o05y	122	35	Finger	Finger	NNP
cord-010604-3d37o05y	122	36	Protein	Protein	NNP
cord-010604-3d37o05y	122	37	219	219	CD
cord-010604-3d37o05y	122	38	and	and	CC
cord-010604-3d37o05y	122	39	SKP2	SKP2	NNP
cord-010604-3d37o05y	122	40	[	[	-LRB-
cord-010604-3d37o05y	122	41	83	83	CD
cord-010604-3d37o05y	122	42	]	]	-RRB-
cord-010604-3d37o05y	122	43	.	.	.
cord-010604-3d37o05y	123	1	While	while	IN
cord-010604-3d37o05y	123	2	the	the	DT
cord-010604-3d37o05y	123	3	functional	functional	JJ
cord-010604-3d37o05y	123	4	consequences	consequence	NNS
cord-010604-3d37o05y	123	5	were	be	VBD
cord-010604-3d37o05y	123	6	not	not	RB
cord-010604-3d37o05y	123	7	explored	explore	VBN
cord-010604-3d37o05y	123	8	in	in	IN
cord-010604-3d37o05y	123	9	this	this	DT
cord-010604-3d37o05y	123	10	report	report	NN
cord-010604-3d37o05y	123	11	,	,	,
cord-010604-3d37o05y	123	12	another	another	DT
cord-010604-3d37o05y	123	13	study	study	NN
cord-010604-3d37o05y	123	14	revealed	reveal	VBD
cord-010604-3d37o05y	123	15	that	that	IN
cord-010604-3d37o05y	123	16	USP49	USP49	NNP
cord-010604-3d37o05y	123	17	stabilizes	stabilize	VBZ
cord-010604-3d37o05y	123	18	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	123	19	by	by	IN
cord-010604-3d37o05y	123	20	the	the	DT
cord-010604-3d37o05y	123	21	removal	removal	NN
cord-010604-3d37o05y	123	22	of	of	IN
cord-010604-3d37o05y	123	23	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	123	24	chains	chain	NNS
cord-010604-3d37o05y	123	25	[	[	-LRB-
cord-010604-3d37o05y	123	26	84	84	CD
cord-010604-3d37o05y	123	27	]	]	-RRB-
cord-010604-3d37o05y	123	28	.	.	.
cord-010604-3d37o05y	124	1	Thus	thus	RB
cord-010604-3d37o05y	124	2	,	,	,
cord-010604-3d37o05y	124	3	in	in	IN
cord-010604-3d37o05y	124	4	this	this	DT
cord-010604-3d37o05y	124	5	case	case	NN
cord-010604-3d37o05y	124	6	,	,	,
cord-010604-3d37o05y	124	7	the	the	DT
cord-010604-3d37o05y	124	8	association	association	NN
cord-010604-3d37o05y	124	9	with	with	IN
cord-010604-3d37o05y	124	10	a	a	DT
cord-010604-3d37o05y	124	11	PTM	PTM	NNP
cord-010604-3d37o05y	124	12	executer	executer	NN
cord-010604-3d37o05y	124	13	results	result	NNS
cord-010604-3d37o05y	124	14	in	in	IN
cord-010604-3d37o05y	124	15	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	124	16	being	be	VBG
cord-010604-3d37o05y	124	17	a	a	DT
cord-010604-3d37o05y	124	18	target	target	NN
cord-010604-3d37o05y	124	19	rather	rather	RB
cord-010604-3d37o05y	124	20	than	than	IN
cord-010604-3d37o05y	124	21	a	a	DT
cord-010604-3d37o05y	124	22	modifier	modifier	NN
cord-010604-3d37o05y	124	23	.	.	.
cord-010604-3d37o05y	125	1	Conversely	conversely	RB
cord-010604-3d37o05y	125	2	,	,	,
cord-010604-3d37o05y	125	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	125	4	regulates	regulate	VBZ
cord-010604-3d37o05y	125	5	the	the	DT
cord-010604-3d37o05y	125	6	ubiquitination	ubiquitination	JJ
cord-010604-3d37o05y	125	7	activity	activity	NN
cord-010604-3d37o05y	125	8	of	of	IN
cord-010604-3d37o05y	125	9	SKP2	SKP2	NNP
cord-010604-3d37o05y	125	10	through	through	IN
cord-010604-3d37o05y	125	11	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	125	12	,	,	,
cord-010604-3d37o05y	125	13	probably	probably	RB
cord-010604-3d37o05y	125	14	by	by	IN
cord-010604-3d37o05y	125	15	functioning	function	VBG
cord-010604-3d37o05y	125	16	as	as	IN
cord-010604-3d37o05y	125	17	protein	protein	NN
cord-010604-3d37o05y	125	18	scaffolder	scaffolder	NN
cord-010604-3d37o05y	125	19	for	for	IN
cord-010604-3d37o05y	125	20	the	the	DT
cord-010604-3d37o05y	125	21	association	association	NN
cord-010604-3d37o05y	125	22	with	with	IN
cord-010604-3d37o05y	125	23	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	125	24	and	and	CC
cord-010604-3d37o05y	125	25	AKT1	AKT1	NNP
cord-010604-3d37o05y	126	1	[	[	-LRB-
cord-010604-3d37o05y	126	2	65	65	CD
cord-010604-3d37o05y	126	3	]	]	-RRB-
cord-010604-3d37o05y	126	4	.	.	.
cord-010604-3d37o05y	127	1	This	this	DT
cord-010604-3d37o05y	128	1	novel	novel	JJ
cord-010604-3d37o05y	128	2	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	128	3	function	function	NN
cord-010604-3d37o05y	128	4	on	on	IN
cord-010604-3d37o05y	128	5	protein	protein	NN
cord-010604-3d37o05y	128	6	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	128	7	has	have	VBZ
cord-010604-3d37o05y	128	8	far	far	RB
cord-010604-3d37o05y	128	9	-	-	HYPH
cord-010604-3d37o05y	128	10	reaching	reach	VBG
cord-010604-3d37o05y	128	11	consequences	consequence	NNS
cord-010604-3d37o05y	128	12	:	:	:
cord-010604-3d37o05y	128	13	The	the	DT
cord-010604-3d37o05y	128	14	study	study	NN
cord-010604-3d37o05y	128	15	further	further	RB
cord-010604-3d37o05y	128	16	discovered	discover	VBD
cord-010604-3d37o05y	128	17	the	the	DT
cord-010604-3d37o05y	128	18	autophagy	autophagy	NN
cord-010604-3d37o05y	128	19	regulator	regulator	NN
cord-010604-3d37o05y	128	20	BECN1	BECN1	NNP
cord-010604-3d37o05y	128	21	as	as	IN
cord-010604-3d37o05y	128	22	novel	novel	JJ
cord-010604-3d37o05y	128	23	target	target	NN
cord-010604-3d37o05y	128	24	of	of	IN
cord-010604-3d37o05y	128	25	SKP2	SKP2	NNP
cord-010604-3d37o05y	128	26	executing	execute	VBG
cord-010604-3d37o05y	128	27	K48-linked	K48-linked	NNP
cord-010604-3d37o05y	128	28	poly	poly	JJ
cord-010604-3d37o05y	128	29	-	-	HYPH
cord-010604-3d37o05y	128	30	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	128	31	at	at	IN
cord-010604-3d37o05y	128	32	this	this	DT
cord-010604-3d37o05y	128	33	autophagy	autophagy	NN
cord-010604-3d37o05y	128	34	regulator	regulator	NN
cord-010604-3d37o05y	128	35	[	[	-LRB-
cord-010604-3d37o05y	128	36	65	65	CD
cord-010604-3d37o05y	128	37	]	]	-RRB-
cord-010604-3d37o05y	128	38	.	.	.
cord-010604-3d37o05y	129	1	Thus	thus	RB
cord-010604-3d37o05y	129	2	,	,	,
cord-010604-3d37o05y	129	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	129	4	drives	drive	VBZ
cord-010604-3d37o05y	129	5	autophagy	autophagy	VBP
cord-010604-3d37o05y	129	6	involving	involve	VBG
cord-010604-3d37o05y	129	7	at	at	RB
cord-010604-3d37o05y	129	8	least	least	RBS
cord-010604-3d37o05y	129	9	two	two	CD
cord-010604-3d37o05y	129	10	types	type	NNS
cord-010604-3d37o05y	129	11	of	of	IN
cord-010604-3d37o05y	129	12	PTMs	ptm	NNS
cord-010604-3d37o05y	129	13	of	of	IN
cord-010604-3d37o05y	129	14	BECN1	BECN1	NNP
cord-010604-3d37o05y	129	15	,	,	,
cord-010604-3d37o05y	129	16	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	129	17	and	and	CC
cord-010604-3d37o05y	129	18	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	129	19	[	[	-LRB-
cord-010604-3d37o05y	129	20	58	58	CD
cord-010604-3d37o05y	129	21	,	,	,
cord-010604-3d37o05y	129	22	64	64	CD
cord-010604-3d37o05y	129	23	,	,	,
cord-010604-3d37o05y	129	24	65	65	CD
cord-010604-3d37o05y	129	25	]	]	-RRB-
cord-010604-3d37o05y	129	26	(	(	-LRB-
cord-010604-3d37o05y	129	27	Figure	figure	NN
cord-010604-3d37o05y	129	28	1C	1c	NN
cord-010604-3d37o05y	129	29	)	)	-RRB-
cord-010604-3d37o05y	129	30	.	.	.
cord-010604-3d37o05y	130	1	Given	give	VBN
cord-010604-3d37o05y	130	2	the	the	DT
cord-010604-3d37o05y	130	3	multiple	multiple	JJ
cord-010604-3d37o05y	130	4	targets	target	NNS
cord-010604-3d37o05y	130	5	of	of	IN
cord-010604-3d37o05y	130	6	SKP2	SKP2	NNP
cord-010604-3d37o05y	130	7	[	[	-LRB-
cord-010604-3d37o05y	130	8	85	85	CD
cord-010604-3d37o05y	130	9	]	]	-RRB-
cord-010604-3d37o05y	130	10	[	[	-LRB-
cord-010604-3d37o05y	130	11	86	86	CD
cord-010604-3d37o05y	130	12	]	]	-RRB-
cord-010604-3d37o05y	130	13	[	[	-LRB-
cord-010604-3d37o05y	130	14	87	87	CD
cord-010604-3d37o05y	130	15	]	]	-RRB-
cord-010604-3d37o05y	130	16	[	[	-LRB-
cord-010604-3d37o05y	130	17	88	88	CD
cord-010604-3d37o05y	130	18	]	]	-RRB-
cord-010604-3d37o05y	130	19	,	,	,
cord-010604-3d37o05y	130	20	it	-PRON-	PRP
cord-010604-3d37o05y	130	21	is	be	VBZ
cord-010604-3d37o05y	130	22	assumed	assume	VBN
cord-010604-3d37o05y	130	23	that	that	IN
cord-010604-3d37o05y	130	24	the	the	DT
cord-010604-3d37o05y	130	25	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	130	26	of	of	IN
cord-010604-3d37o05y	130	27	more	more	JJR
cord-010604-3d37o05y	130	28	proteins	protein	NNS
cord-010604-3d37o05y	130	29	will	will	MD
cord-010604-3d37o05y	130	30	be	be	VB
cord-010604-3d37o05y	130	31	changed	change	VBN
cord-010604-3d37o05y	130	32	by	by	IN
cord-010604-3d37o05y	130	33	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	130	34	with	with	IN
cord-010604-3d37o05y	130	35	diverse	diverse	JJ
cord-010604-3d37o05y	130	36	functional	functional	JJ
cord-010604-3d37o05y	130	37	consequences	consequence	NNS
cord-010604-3d37o05y	130	38	.	.	.
cord-010604-3d37o05y	131	1	Autophagy	Autophagy	NNP
cord-010604-3d37o05y	131	2	is	be	VBZ
cord-010604-3d37o05y	131	3	another	another	DT
cord-010604-3d37o05y	131	4	fundamental	fundamental	JJ
cord-010604-3d37o05y	131	5	cellular	cellular	JJ
cord-010604-3d37o05y	131	6	process	process	NN
cord-010604-3d37o05y	131	7	essential	essential	JJ
cord-010604-3d37o05y	131	8	for	for	IN
cord-010604-3d37o05y	131	9	protein	protein	NN
cord-010604-3d37o05y	131	10	,	,	,
cord-010604-3d37o05y	131	11	organelle	organelle	NN
cord-010604-3d37o05y	131	12	and	and	CC
cord-010604-3d37o05y	131	13	energy	energy	NN
cord-010604-3d37o05y	131	14	homeostasis	homeostasis	NN
cord-010604-3d37o05y	131	15	[	[	-LRB-
cord-010604-3d37o05y	131	16	89	89	CD
cord-010604-3d37o05y	131	17	]	]	-RRB-
cord-010604-3d37o05y	131	18	.	.	.
cord-010604-3d37o05y	132	1	It	-PRON-	PRP
cord-010604-3d37o05y	132	2	involves	involve	VBZ
cord-010604-3d37o05y	132	3	several	several	JJ
cord-010604-3d37o05y	132	4	ATG	ATG	NNP
cord-010604-3d37o05y	132	5	products	product	NNS
cord-010604-3d37o05y	132	6	that	that	IN
cord-010604-3d37o05y	132	7	through	through	IN
cord-010604-3d37o05y	132	8	several	several	JJ
cord-010604-3d37o05y	132	9	steps	step	NNS
cord-010604-3d37o05y	132	10	form	form	VBP
cord-010604-3d37o05y	132	11	autophagosomes	autophagosomes	NNP
cord-010604-3d37o05y	132	12	,	,	,
cord-010604-3d37o05y	132	13	vesicles	vesicle	NNS
cord-010604-3d37o05y	132	14	that	that	WDT
cord-010604-3d37o05y	132	15	engulf	engulf	VBP
cord-010604-3d37o05y	132	16	material	material	NN
cord-010604-3d37o05y	132	17	destined	destine	VBN
cord-010604-3d37o05y	132	18	for	for	IN
cord-010604-3d37o05y	132	19	degradation	degradation	NN
cord-010604-3d37o05y	132	20	which	which	WDT
cord-010604-3d37o05y	132	21	is	be	VBZ
cord-010604-3d37o05y	132	22	accomplished	accomplish	VBN
cord-010604-3d37o05y	132	23	upon	upon	IN
cord-010604-3d37o05y	132	24	the	the	DT
cord-010604-3d37o05y	132	25	fusion	fusion	NN
cord-010604-3d37o05y	132	26	with	with	IN
cord-010604-3d37o05y	132	27	lysosomes	lysosome	NNS
cord-010604-3d37o05y	132	28	[	[	-LRB-
cord-010604-3d37o05y	132	29	89	89	CD
cord-010604-3d37o05y	132	30	,	,	,
cord-010604-3d37o05y	132	31	90	90	CD
cord-010604-3d37o05y	132	32	]	]	-RRB-
cord-010604-3d37o05y	132	33	.	.	.
cord-010604-3d37o05y	133	1	An	an	DT
cord-010604-3d37o05y	133	2	important	important	JJ
cord-010604-3d37o05y	133	3	step	step	NN
cord-010604-3d37o05y	133	4	in	in	IN
cord-010604-3d37o05y	133	5	this	this	DT
cord-010604-3d37o05y	133	6	process	process	NN
cord-010604-3d37o05y	133	7	is	be	VBZ
cord-010604-3d37o05y	133	8	the	the	DT
cord-010604-3d37o05y	133	9	lipidation	lipidation	NN
cord-010604-3d37o05y	133	10	of	of	IN
cord-010604-3d37o05y	133	11	ATG8	ATG8	NNP
cord-010604-3d37o05y	133	12	(	(	-LRB-
cord-010604-3d37o05y	133	13	also	also	RB
cord-010604-3d37o05y	133	14	known	know	VBN
cord-010604-3d37o05y	133	15	as	as	IN
cord-010604-3d37o05y	133	16	microtubule	microtubule	NN
cord-010604-3d37o05y	133	17	associated	associate	VBD
cord-010604-3d37o05y	133	18	protein	protein	NN
cord-010604-3d37o05y	133	19	1	1	CD
cord-010604-3d37o05y	133	20	light	light	JJ
cord-010604-3d37o05y	133	21	chain	chain	NN
cord-010604-3d37o05y	133	22	3	3	CD
cord-010604-3d37o05y	133	23	beta	beta	NN
cord-010604-3d37o05y	133	24	)	)	-RRB-
cord-010604-3d37o05y	133	25	,	,	,
cord-010604-3d37o05y	133	26	a	a	DT
cord-010604-3d37o05y	133	27	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	133	28	-	-	HYPH
cord-010604-3d37o05y	133	29	like	like	JJ
cord-010604-3d37o05y	133	30	protein	protein	NN
cord-010604-3d37o05y	133	31	that	that	WDT
cord-010604-3d37o05y	133	32	is	be	VBZ
cord-010604-3d37o05y	133	33	integrated	integrate	VBN
cord-010604-3d37o05y	133	34	into	into	IN
cord-010604-3d37o05y	133	35	the	the	DT
cord-010604-3d37o05y	133	36	autophagosomal	autophagosomal	NN
cord-010604-3d37o05y	133	37	membrane	membrane	NN
cord-010604-3d37o05y	133	38	upon	upon	IN
cord-010604-3d37o05y	133	39	formation	formation	NN
cord-010604-3d37o05y	133	40	of	of	IN
cord-010604-3d37o05y	133	41	an	an	DT
cord-010604-3d37o05y	133	42	amide	amide	NN
cord-010604-3d37o05y	133	43	bond	bond	NN
cord-010604-3d37o05y	134	1	The	the	DT
cord-010604-3d37o05y	134	2	stress	stress	NN
cord-010604-3d37o05y	134	3	protein	protein	NN
cord-010604-3d37o05y	134	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	134	5	is	be	VBZ
cord-010604-3d37o05y	134	6	intertwined	intertwine	VBN
cord-010604-3d37o05y	134	7	with	with	IN
cord-010604-3d37o05y	134	8	GR	GR	NNP
cord-010604-3d37o05y	134	9	as	as	IN
cord-010604-3d37o05y	134	10	both	both	DT
cord-010604-3d37o05y	134	11	inhibitor	inhibitor	NN
cord-010604-3d37o05y	134	12	and	and	CC
cord-010604-3d37o05y	134	13	target	target	NN
cord-010604-3d37o05y	134	14	.	.	.
cord-010604-3d37o05y	135	1	As	as	IN
cord-010604-3d37o05y	135	2	target	target	NN
cord-010604-3d37o05y	135	3	,	,	,
cord-010604-3d37o05y	135	4	it	-PRON-	PRP
cord-010604-3d37o05y	135	5	has	have	VBZ
cord-010604-3d37o05y	135	6	the	the	DT
cord-010604-3d37o05y	135	7	potential	potential	NN
cord-010604-3d37o05y	135	8	to	to	TO
cord-010604-3d37o05y	135	9	relay	relay	VB
cord-010604-3d37o05y	135	10	the	the	DT
cord-010604-3d37o05y	135	11	stress	stress	NN
cord-010604-3d37o05y	135	12	response	response	NN
cord-010604-3d37o05y	135	13	to	to	IN
cord-010604-3d37o05y	135	14	downstream	downstream	JJ
cord-010604-3d37o05y	135	15	pathways	pathway	NNS
cord-010604-3d37o05y	135	16	through	through	IN
cord-010604-3d37o05y	135	17	the	the	DT
cord-010604-3d37o05y	135	18	association	association	NN
cord-010604-3d37o05y	135	19	with	with	IN
cord-010604-3d37o05y	135	20	writers	writer	NNS
cord-010604-3d37o05y	135	21	and	and	CC
cord-010604-3d37o05y	135	22	erasers	eraser	NNS
cord-010604-3d37o05y	135	23	of	of	IN
cord-010604-3d37o05y	135	24	PTMs	ptm	NNS
cord-010604-3d37o05y	135	25	.	.	.
cord-010604-3d37o05y	136	1	Known	know	VBN
cord-010604-3d37o05y	136	2	associations	association	NNS
cord-010604-3d37o05y	136	3	include	include	VBP
cord-010604-3d37o05y	136	4	de	de	NNP
cord-010604-3d37o05y	136	5	-	-	HYPH
cord-010604-3d37o05y	136	6	ubiquitinases	ubiquitinase	NNS
cord-010604-3d37o05y	136	7	,	,	,
cord-010604-3d37o05y	136	8	ubiquitinases	ubiquitinase	NNS
cord-010604-3d37o05y	136	9	,	,	,
cord-010604-3d37o05y	136	10	protein	protein	NN
cord-010604-3d37o05y	136	11	kinases	kinase	NNS
cord-010604-3d37o05y	136	12	and	and	CC
cord-010604-3d37o05y	136	13	protein	protein	NN
cord-010604-3d37o05y	136	14	phosphatases	phosphatase	NNS
cord-010604-3d37o05y	136	15	(	(	-LRB-
cord-010604-3d37o05y	136	16	first	first	JJ
cord-010604-3d37o05y	136	17	box	box	NN
cord-010604-3d37o05y	136	18	,	,	,
cord-010604-3d37o05y	136	19	writers	writer	NNS
cord-010604-3d37o05y	136	20	and	and	CC
cord-010604-3d37o05y	136	21	erasers	eraser	NNS
cord-010604-3d37o05y	136	22	of	of	IN
cord-010604-3d37o05y	136	23	PTMs	ptm	NNS
cord-010604-3d37o05y	136	24	are	be	VBP
cord-010604-3d37o05y	136	25	grouped	group	VBN
cord-010604-3d37o05y	136	26	according	accord	VBG
cord-010604-3d37o05y	136	27	to	to	IN
cord-010604-3d37o05y	136	28	the	the	DT
cord-010604-3d37o05y	136	29	type	type	NN
cord-010604-3d37o05y	136	30	of	of	IN
cord-010604-3d37o05y	136	31	their	-PRON-	PRP$
cord-010604-3d37o05y	136	32	biochemical	biochemical	JJ
cord-010604-3d37o05y	136	33	activity	activity	NN
cord-010604-3d37o05y	136	34	)	)	-RRB-
cord-010604-3d37o05y	136	35	.	.	.
cord-010604-3d37o05y	137	1	Some	some	DT
cord-010604-3d37o05y	137	2	of	of	IN
cord-010604-3d37o05y	137	3	the	the	DT
cord-010604-3d37o05y	137	4	associated	associate	VBN
cord-010604-3d37o05y	137	5	proteins	protein	NNS
cord-010604-3d37o05y	137	6	are	be	VBP
cord-010604-3d37o05y	137	7	changed	change	VBN
cord-010604-3d37o05y	137	8	in	in	IN
cord-010604-3d37o05y	137	9	their	-PRON-	PRP$
cord-010604-3d37o05y	137	10	activity	activity	NN
cord-010604-3d37o05y	137	11	,	,	,
cord-010604-3d37o05y	137	12	others	other	NNS
cord-010604-3d37o05y	137	13	are	be	VBP
cord-010604-3d37o05y	137	14	redirected	redirect	VBN
cord-010604-3d37o05y	137	15	to	to	IN
cord-010604-3d37o05y	137	16	certain	certain	JJ
cord-010604-3d37o05y	137	17	targets	target	NNS
cord-010604-3d37o05y	137	18	.	.	.
cord-010604-3d37o05y	138	1	Examples	example	NNS
cord-010604-3d37o05y	138	2	of	of	IN
cord-010604-3d37o05y	138	3	target	target	NN
cord-010604-3d37o05y	138	4	proteins	protein	NNS
cord-010604-3d37o05y	138	5	affected	affect	VBN
cord-010604-3d37o05y	138	6	by	by	IN
cord-010604-3d37o05y	138	7	the	the	DT
cord-010604-3d37o05y	138	8	altered	alter	VBN
cord-010604-3d37o05y	138	9	activities	activity	NNS
cord-010604-3d37o05y	138	10	of	of	IN
cord-010604-3d37o05y	138	11	PTM	PTM	NNP
cord-010604-3d37o05y	138	12	writers	writer	NNS
cord-010604-3d37o05y	138	13	and	and	CC
cord-010604-3d37o05y	138	14	erasers	eraser	NNS
cord-010604-3d37o05y	138	15	are	be	VBP
cord-010604-3d37o05y	138	16	provided	provide	VBN
cord-010604-3d37o05y	138	17	in	in	IN
cord-010604-3d37o05y	138	18	the	the	DT
cord-010604-3d37o05y	138	19	box	box	NN
cord-010604-3d37o05y	138	20	below	below	RB
cord-010604-3d37o05y	138	21	.	.	.
cord-010604-3d37o05y	138	22	'	'	''
cord-010604-3d37o05y	139	1	+	+	CC
cord-010604-3d37o05y	139	2	'	'	``
cord-010604-3d37o05y	139	3	and	and	CC
cord-010604-3d37o05y	139	4	'	'	``
cord-010604-3d37o05y	139	5	−	−	NNP
cord-010604-3d37o05y	139	6	'	'	''
cord-010604-3d37o05y	139	7	after	after	IN
cord-010604-3d37o05y	139	8	the	the	DT
cord-010604-3d37o05y	139	9	protein	protein	NN
cord-010604-3d37o05y	139	10	names	name	NNS
cord-010604-3d37o05y	139	11	indicate	indicate	VBP
cord-010604-3d37o05y	139	12	the	the	DT
cord-010604-3d37o05y	139	13	overall	overall	JJ
cord-010604-3d37o05y	139	14	effect	effect	NN
cord-010604-3d37o05y	139	15	of	of	IN
cord-010604-3d37o05y	139	16	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	139	17	on	on	IN
cord-010604-3d37o05y	139	18	the	the	DT
cord-010604-3d37o05y	139	19	activity	activity	NN
cord-010604-3d37o05y	139	20	of	of	IN
cord-010604-3d37o05y	139	21	associating	associate	VBG
cord-010604-3d37o05y	139	22	proteins	protein	NNS
cord-010604-3d37o05y	139	23	or	or	CC
cord-010604-3d37o05y	139	24	downstream	downstream	JJ
cord-010604-3d37o05y	139	25	proteins	protein	NNS
cord-010604-3d37o05y	139	26	.	.	.
cord-010604-3d37o05y	140	1	Not	not	RB
cord-010604-3d37o05y	140	2	all	all	DT
cord-010604-3d37o05y	140	3	potential	potential	JJ
cord-010604-3d37o05y	140	4	interactions	interaction	NNS
cord-010604-3d37o05y	140	5	are	be	VBP
cord-010604-3d37o05y	140	6	displayed	display	VBN
cord-010604-3d37o05y	140	7	.	.	.
cord-010604-3d37o05y	141	1	BECN1	BECN1	NNP
cord-010604-3d37o05y	141	2	is	be	VBZ
cord-010604-3d37o05y	141	3	a	a	DT
cord-010604-3d37o05y	141	4	downstream	downstream	JJ
cord-010604-3d37o05y	141	5	protein	protein	NN
cord-010604-3d37o05y	141	6	that	that	WDT
cord-010604-3d37o05y	141	7	also	also	RB
cord-010604-3d37o05y	141	8	forms	form	VBZ
cord-010604-3d37o05y	141	9	a	a	DT
cord-010604-3d37o05y	141	10	complex	complex	NN
cord-010604-3d37o05y	141	11	with	with	IN
cord-010604-3d37o05y	141	12	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	141	13	.	.	.
cord-010604-3d37o05y	142	1	However	however	RB
cord-010604-3d37o05y	142	2	,	,	,
cord-010604-3d37o05y	142	3	most	most	JJS
cord-010604-3d37o05y	142	4	of	of	IN
cord-010604-3d37o05y	142	5	the	the	DT
cord-010604-3d37o05y	142	6	downstream	downstream	JJ
cord-010604-3d37o05y	142	7	target	target	NN
cord-010604-3d37o05y	142	8	proteins	protein	NNS
cord-010604-3d37o05y	142	9	are	be	VBP
cord-010604-3d37o05y	142	10	indirectly	indirectly	RB
cord-010604-3d37o05y	142	11	affected	affect	VBN
cord-010604-3d37o05y	142	12	in	in	IN
cord-010604-3d37o05y	142	13	the	the	DT
cord-010604-3d37o05y	142	14	sense	sense	NN
cord-010604-3d37o05y	142	15	that	that	IN
cord-010604-3d37o05y	142	16	they	-PRON-	PRP
cord-010604-3d37o05y	142	17	were	be	VBD
cord-010604-3d37o05y	142	18	not	not	RB
cord-010604-3d37o05y	142	19	shown	show	VBN
cord-010604-3d37o05y	142	20	to	to	TO
cord-010604-3d37o05y	142	21	associate	associate	VB
cord-010604-3d37o05y	142	22	with	with	IN
cord-010604-3d37o05y	142	23	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	142	24	.	.	.
cord-010604-3d37o05y	143	1	with	with	IN
cord-010604-3d37o05y	143	2	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-010604-3d37o05y	143	3	[	[	-LRB-
cord-010604-3d37o05y	143	4	91	91	CD
cord-010604-3d37o05y	143	5	,	,	,
cord-010604-3d37o05y	143	6	92	92	CD
cord-010604-3d37o05y	143	7	]	]	-RRB-
cord-010604-3d37o05y	143	8	.	.	.
cord-010604-3d37o05y	144	1	Similar	similar	JJ
cord-010604-3d37o05y	144	2	to	to	IN
cord-010604-3d37o05y	144	3	the	the	DT
cord-010604-3d37o05y	144	4	process	process	NN
cord-010604-3d37o05y	144	5	of	of	IN
cord-010604-3d37o05y	144	6	ubiquitination	ubiquitination	NN
cord-010604-3d37o05y	144	7	,	,	,
cord-010604-3d37o05y	144	8	the	the	DT
cord-010604-3d37o05y	144	9	formation	formation	NN
cord-010604-3d37o05y	144	10	of	of	IN
cord-010604-3d37o05y	144	11	this	this	DT
cord-010604-3d37o05y	144	12	amide	amide	NN
cord-010604-3d37o05y	144	13	bond	bond	NN
cord-010604-3d37o05y	144	14	is	be	VBZ
cord-010604-3d37o05y	144	15	executed	execute	VBN
cord-010604-3d37o05y	144	16	by	by	IN
cord-010604-3d37o05y	144	17	a	a	DT
cord-010604-3d37o05y	144	18	set	set	NN
cord-010604-3d37o05y	144	19	of	of	IN
cord-010604-3d37o05y	144	20	ligases	ligase	NNS
cord-010604-3d37o05y	144	21	(	(	-LRB-
cord-010604-3d37o05y	144	22	E1-E3	E1-E3	NNP
cord-010604-3d37o05y	144	23	)	)	-RRB-
cord-010604-3d37o05y	144	24	that	that	WDT
cord-010604-3d37o05y	144	25	use	use	VBP
cord-010604-3d37o05y	144	26	cysteine	cysteine	NN
cord-010604-3d37o05y	144	27	linked	link	VBN
cord-010604-3d37o05y	144	28	thioesters	thioester	NNS
cord-010604-3d37o05y	144	29	as	as	IN
cord-010604-3d37o05y	144	30	intermediates	intermediate	NNS
cord-010604-3d37o05y	144	31	.	.	.
cord-010604-3d37o05y	145	1	The	the	DT
cord-010604-3d37o05y	145	2	last	last	JJ
cord-010604-3d37o05y	145	3	step	step	NN
cord-010604-3d37o05y	145	4	,	,	,
cord-010604-3d37o05y	145	5	conjugation	conjugation	NN
cord-010604-3d37o05y	145	6	to	to	IN
cord-010604-3d37o05y	145	7	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-010604-3d37o05y	145	8	,	,	,
cord-010604-3d37o05y	145	9	is	be	VBZ
cord-010604-3d37o05y	145	10	mediated	mediate	VBN
cord-010604-3d37o05y	145	11	by	by	IN
cord-010604-3d37o05y	145	12	the	the	DT
cord-010604-3d37o05y	145	13	E3-like	e3-like	NN
cord-010604-3d37o05y	145	14	Atg12-Atg5	Atg12-Atg5	NNP
cord-010604-3d37o05y	145	15	:	:	:
cord-010604-3d37o05y	146	1	Atg16	Atg16	NNP
cord-010604-3d37o05y	146	2	complex	complex	JJ
cord-010604-3d37o05y	146	3	[	[	-LRB-
cord-010604-3d37o05y	146	4	93	93	CD
cord-010604-3d37o05y	146	5	]	]	-RRB-
cord-010604-3d37o05y	146	6	.	.	.
cord-010604-3d37o05y	147	1	The	the	DT
cord-010604-3d37o05y	147	2	effect	effect	NN
cord-010604-3d37o05y	147	3	of	of	IN
cord-010604-3d37o05y	147	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	147	5	on	on	IN
cord-010604-3d37o05y	147	6	this	this	DT
cord-010604-3d37o05y	147	7	protein	protein	NN
cord-010604-3d37o05y	147	8	lipidation	lipidation	NN
cord-010604-3d37o05y	147	9	probably	probably	RB
cord-010604-3d37o05y	147	10	is	be	VBZ
cord-010604-3d37o05y	147	11	indirect	indirect	JJ
cord-010604-3d37o05y	147	12	through	through	IN
cord-010604-3d37o05y	147	13	driving	drive	VBG
cord-010604-3d37o05y	147	14	autophagy	autophagy	NN
cord-010604-3d37o05y	147	15	by	by	IN
cord-010604-3d37o05y	147	16	regulating	regulate	VBG
cord-010604-3d37o05y	147	17	BECN1	BECN1	NNP
cord-010604-3d37o05y	147	18	.	.	.
cord-010604-3d37o05y	148	1	However	however	RB
cord-010604-3d37o05y	148	2	,	,	,
cord-010604-3d37o05y	148	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	148	4	also	also	RB
cord-010604-3d37o05y	148	5	leads	lead	VBZ
cord-010604-3d37o05y	148	6	to	to	IN
cord-010604-3d37o05y	148	7	enhanced	enhanced	JJ
cord-010604-3d37o05y	148	8	levels	level	NNS
cord-010604-3d37o05y	148	9	of	of	IN
cord-010604-3d37o05y	148	10	ATG12	ATG12	NNP
cord-010604-3d37o05y	148	11	,	,	,
cord-010604-3d37o05y	148	12	a	a	DT
cord-010604-3d37o05y	148	13	member	member	NN
cord-010604-3d37o05y	148	14	of	of	IN
cord-010604-3d37o05y	148	15	the	the	DT
cord-010604-3d37o05y	148	16	conjugation	conjugation	NN
cord-010604-3d37o05y	148	17	system	system	NN
cord-010604-3d37o05y	148	18	[	[	-LRB-
cord-010604-3d37o05y	148	19	58	58	CD
cord-010604-3d37o05y	148	20	]	]	-RRB-
cord-010604-3d37o05y	148	21	,	,	,
cord-010604-3d37o05y	148	22	pointing	point	VBG
cord-010604-3d37o05y	148	23	to	to	IN
cord-010604-3d37o05y	148	24	different	different	JJ
cord-010604-3d37o05y	148	25	pathways	pathway	NNS
cord-010604-3d37o05y	148	26	used	use	VBN
cord-010604-3d37o05y	148	27	by	by	IN
cord-010604-3d37o05y	148	28	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	148	29	to	to	TO
cord-010604-3d37o05y	148	30	enhance	enhance	VB
cord-010604-3d37o05y	148	31	ATG8	ATG8	NNP
cord-010604-3d37o05y	148	32	lipidation	lipidation	NN
cord-010604-3d37o05y	148	33	.	.	.
cord-010604-3d37o05y	149	1	•	•	NNP
cord-010604-3d37o05y	150	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	150	2	is	be	VBZ
cord-010604-3d37o05y	150	3	receiving	receive	VBG
cord-010604-3d37o05y	150	4	increased	increase	VBN
cord-010604-3d37o05y	150	5	attention	attention	NN
cord-010604-3d37o05y	150	6	for	for	IN
cord-010604-3d37o05y	150	7	its	-PRON-	PRP$
cord-010604-3d37o05y	150	8	pivotal	pivotal	JJ
cord-010604-3d37o05y	150	9	role	role	NN
cord-010604-3d37o05y	150	10	in	in	IN
cord-010604-3d37o05y	150	11	research	research	NN
cord-010604-3d37o05y	150	12	on	on	IN
cord-010604-3d37o05y	150	13	stress	stress	NN
cord-010604-3d37o05y	150	14	and	and	CC
cord-010604-3d37o05y	150	15	stressrelated	stressrelated	JJ
cord-010604-3d37o05y	150	16	diseases	disease	NNS
cord-010604-3d37o05y	150	17	,	,	,
cord-010604-3d37o05y	150	18	but	but	CC
cord-010604-3d37o05y	150	19	also	also	RB
cord-010604-3d37o05y	150	20	several	several	JJ
cord-010604-3d37o05y	150	21	additional	additional	JJ
cord-010604-3d37o05y	150	22	fields	field	NNS
cord-010604-3d37o05y	150	23	such	such	JJ
cord-010604-3d37o05y	150	24	as	as	IN
cord-010604-3d37o05y	150	25	immunology	immunology	NN
cord-010604-3d37o05y	150	26	,	,	,
cord-010604-3d37o05y	150	27	metabolism	metabolism	NN
cord-010604-3d37o05y	150	28	,	,	,
cord-010604-3d37o05y	150	29	oncology	oncology	NN
cord-010604-3d37o05y	150	30	,	,	,
cord-010604-3d37o05y	150	31	neurology	neurology	NN
cord-010604-3d37o05y	150	32	,	,	,
cord-010604-3d37o05y	150	33	etc	etc	FW
cord-010604-3d37o05y	150	34	.	.	.
cord-010604-3d37o05y	151	1	•	•	NNP
cord-010604-3d37o05y	152	1	The	the	DT
cord-010604-3d37o05y	152	2	stress	stress	NN
cord-010604-3d37o05y	152	3	protein	protein	NN
cord-010604-3d37o05y	152	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	152	5	is	be	VBZ
cord-010604-3d37o05y	152	6	engaged	engage	VBN
cord-010604-3d37o05y	152	7	in	in	IN
cord-010604-3d37o05y	152	8	various	various	JJ
cord-010604-3d37o05y	152	9	signaling	signal	VBG
cord-010604-3d37o05y	152	10	pathways	pathway	NNS
cord-010604-3d37o05y	152	11	through	through	IN
cord-010604-3d37o05y	152	12	diverse	diverse	JJ
cord-010604-3d37o05y	152	13	protein	protein	NN
cord-010604-3d37o05y	152	14	interactions	interaction	NNS
cord-010604-3d37o05y	152	15	.	.	.
cord-010604-3d37o05y	153	1	It	-PRON-	PRP
cord-010604-3d37o05y	153	2	both	both	DT
cord-010604-3d37o05y	153	3	affects	affect	VBZ
cord-010604-3d37o05y	153	4	the	the	DT
cord-010604-3d37o05y	153	5	stress	stress	NN
cord-010604-3d37o05y	153	6	response	response	NN
cord-010604-3d37o05y	153	7	and	and	CC
cord-010604-3d37o05y	153	8	is	be	VBZ
cord-010604-3d37o05y	153	9	affected	affect	VBN
cord-010604-3d37o05y	153	10	by	by	IN
cord-010604-3d37o05y	153	11	the	the	DT
cord-010604-3d37o05y	153	12	stress	stress	NN
cord-010604-3d37o05y	153	13	response	response	NN
cord-010604-3d37o05y	153	14	,	,	,
cord-010604-3d37o05y	153	15	and	and	CC
cord-010604-3d37o05y	153	16	furthermore	furthermore	RB
cord-010604-3d37o05y	153	17	relays	relay	VBZ
cord-010604-3d37o05y	153	18	stress	stress	NN
cord-010604-3d37o05y	153	19	to	to	IN
cord-010604-3d37o05y	153	20	multiple	multiple	JJ
cord-010604-3d37o05y	153	21	pathways	pathway	NNS
cord-010604-3d37o05y	153	22	.	.	.
cord-010604-3d37o05y	154	1	Likewise	likewise	RB
cord-010604-3d37o05y	154	2	,	,	,
cord-010604-3d37o05y	154	3	it	-PRON-	PRP
cord-010604-3d37o05y	154	4	is	be	VBZ
cord-010604-3d37o05y	154	5	the	the	DT
cord-010604-3d37o05y	154	6	subject	subject	NN
cord-010604-3d37o05y	154	7	of	of	IN
cord-010604-3d37o05y	154	8	PTMs	ptm	NNS
cord-010604-3d37o05y	154	9	and	and	CC
cord-010604-3d37o05y	154	10	affects	affect	VBZ
cord-010604-3d37o05y	154	11	the	the	DT
cord-010604-3d37o05y	154	12	activity	activity	NN
cord-010604-3d37o05y	154	13	of	of	IN
cord-010604-3d37o05y	154	14	PTM	PTM	NNP
cord-010604-3d37o05y	154	15	writers	writer	NNS
cord-010604-3d37o05y	154	16	and	and	CC
cord-010604-3d37o05y	154	17	erasers	eraser	NNS
cord-010604-3d37o05y	154	18	(	(	-LRB-
cord-010604-3d37o05y	154	19	Figure	figure	NN
cord-010604-3d37o05y	154	20	2	2	CD
cord-010604-3d37o05y	154	21	)	)	-RRB-
cord-010604-3d37o05y	154	22	.	.	.
cord-010604-3d37o05y	155	1	•	•	NNP
cord-010604-3d37o05y	156	1	Protein	protein	NN
cord-010604-3d37o05y	156	2	associations	association	NNS
cord-010604-3d37o05y	156	3	of	of	IN
cord-010604-3d37o05y	156	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	156	5	with	with	IN
cord-010604-3d37o05y	156	6	PTM	PTM	NNP
cord-010604-3d37o05y	156	7	writers	writer	NNS
cord-010604-3d37o05y	156	8	and	and	CC
cord-010604-3d37o05y	156	9	erasers	eraser	NNS
cord-010604-3d37o05y	156	10	could	could	MD
cord-010604-3d37o05y	156	11	affect	affect	VB
cord-010604-3d37o05y	156	12	PTMs	ptm	NNS
cord-010604-3d37o05y	156	13	of	of	IN
cord-010604-3d37o05y	156	14	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	156	15	itself	-PRON-	PRP
cord-010604-3d37o05y	156	16	or	or	CC
cord-010604-3d37o05y	156	17	of	of	IN
cord-010604-3d37o05y	156	18	other	other	JJ
cord-010604-3d37o05y	156	19	proteins	protein	NNS
cord-010604-3d37o05y	156	20	,	,	,
cord-010604-3d37o05y	156	21	and	and	CC
cord-010604-3d37o05y	156	22	deciphering	decipher	VBG
cord-010604-3d37o05y	156	23	these	these	DT
cord-010604-3d37o05y	156	24	scenarios	scenario	NNS
cord-010604-3d37o05y	156	25	will	will	MD
cord-010604-3d37o05y	156	26	significantly	significantly	RB
cord-010604-3d37o05y	156	27	contribute	contribute	VB
cord-010604-3d37o05y	156	28	to	to	IN
cord-010604-3d37o05y	156	29	our	-PRON-	PRP$
cord-010604-3d37o05y	156	30	mechanistic	mechanistic	JJ
cord-010604-3d37o05y	156	31	understanding	understanding	NN
cord-010604-3d37o05y	156	32	of	of	IN
cord-010604-3d37o05y	156	33	this	this	DT
cord-010604-3d37o05y	156	34	versatile	versatile	JJ
cord-010604-3d37o05y	156	35	protein	protein	NN
cord-010604-3d37o05y	156	36	.	.	.
cord-010604-3d37o05y	157	1	Furthermore	furthermore	RB
cord-010604-3d37o05y	157	2	,	,	,
cord-010604-3d37o05y	157	3	it	-PRON-	PRP
cord-010604-3d37o05y	157	4	will	will	MD
cord-010604-3d37o05y	157	5	be	be	VB
cord-010604-3d37o05y	157	6	of	of	IN
cord-010604-3d37o05y	157	7	high	high	JJ
cord-010604-3d37o05y	157	8	interest	interest	NN
cord-010604-3d37o05y	157	9	to	to	TO
cord-010604-3d37o05y	157	10	elucidate	elucidate	VB
cord-010604-3d37o05y	157	11	which	which	WDT
cord-010604-3d37o05y	157	12	of	of	IN
cord-010604-3d37o05y	157	13	the	the	DT
cord-010604-3d37o05y	157	14	PTM	PTM	NNP
cord-010604-3d37o05y	157	15	-	-	HYPH
cord-010604-3d37o05y	157	16	mediated	mediate	VBN
cord-010604-3d37o05y	157	17	downstream	downstream	JJ
cord-010604-3d37o05y	157	18	effects	effect	NNS
cord-010604-3d37o05y	157	19	of	of	IN
cord-010604-3d37o05y	157	20	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	157	21	contribute	contribute	NN
cord-010604-3d37o05y	157	22	to	to	IN
cord-010604-3d37o05y	157	23	the	the	DT
cord-010604-3d37o05y	157	24	physiological	physiological	JJ
cord-010604-3d37o05y	157	25	stress	stress	NN
cord-010604-3d37o05y	157	26	reaction	reaction	NN
cord-010604-3d37o05y	157	27	.	.	.
cord-010604-3d37o05y	158	1	The	the	DT
cord-010604-3d37o05y	158	2	author	author	NN
cord-010604-3d37o05y	158	3	declares	declare	VBZ
cord-010604-3d37o05y	158	4	that	that	IN
cord-010604-3d37o05y	158	5	there	there	EX
cord-010604-3d37o05y	158	6	are	be	VBP
cord-010604-3d37o05y	158	7	no	no	DT
cord-010604-3d37o05y	158	8	competing	compete	VBG
cord-010604-3d37o05y	158	9	interests	interest	NNS
cord-010604-3d37o05y	158	10	associated	associate	VBN
cord-010604-3d37o05y	158	11	with	with	IN
cord-010604-3d37o05y	158	12	this	this	DT
cord-010604-3d37o05y	158	13	manuscript	manuscript	NN
cord-010604-3d37o05y	158	14	.	.	.
cord-010604-3d37o05y	159	1	ATG	ATG	NNP
cord-010604-3d37o05y	159	2	,	,	,
cord-010604-3d37o05y	159	3	autophagy	autophagy	NN
cord-010604-3d37o05y	159	4	-	-	HYPH
cord-010604-3d37o05y	159	5	related	relate	VBN
cord-010604-3d37o05y	159	6	gene	gene	NN
cord-010604-3d37o05y	159	7	;	;	:
cord-010604-3d37o05y	159	8	BECN1	BECN1	NNP
cord-010604-3d37o05y	159	9	,	,	,
cord-010604-3d37o05y	159	10	Beclin	Beclin	NNP
cord-010604-3d37o05y	159	11	1	1	CD
cord-010604-3d37o05y	159	12	;	;	:
cord-010604-3d37o05y	159	13	CDK	CDK	NNP
cord-010604-3d37o05y	159	14	,	,	,
cord-010604-3d37o05y	159	15	cyclin	cyclin	NN
cord-010604-3d37o05y	159	16	-	-	HYPH
cord-010604-3d37o05y	159	17	dependent	dependent	JJ
cord-010604-3d37o05y	159	18	kinase	kinase	NN
cord-010604-3d37o05y	159	19	;	;	:
cord-010604-3d37o05y	159	20	DLC	DLC	NNP
cord-010604-3d37o05y	159	21	,	,	,
cord-010604-3d37o05y	159	22	deleted	delete	VBN
cord-010604-3d37o05y	159	23	in	in	IN
cord-010604-3d37o05y	159	24	liver	liver	NN
cord-010604-3d37o05y	159	25	cancer	cancer	NN
cord-010604-3d37o05y	159	26	;	;	:
cord-010604-3d37o05y	159	27	DNMT1	DNMT1	NNP
cord-010604-3d37o05y	159	28	,	,	,
cord-010604-3d37o05y	159	29	DNA	dna	NN
cord-010604-3d37o05y	159	30	methyltransferase	methyltransferase	NN
cord-010604-3d37o05y	159	31	1	1	CD
cord-010604-3d37o05y	159	32	;	;	:
cord-010604-3d37o05y	159	33	FKBP	FKBP	NNP
cord-010604-3d37o05y	159	34	,	,	,
cord-010604-3d37o05y	159	35	FK506	fk506	JJ
cord-010604-3d37o05y	159	36	binding	bind	VBG
cord-010604-3d37o05y	159	37	protein	protein	NN
cord-010604-3d37o05y	159	38	;	;	:
cord-010604-3d37o05y	159	39	GR	GR	NNP
cord-010604-3d37o05y	159	40	,	,	,
cord-010604-3d37o05y	159	41	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	159	42	receptor	receptor	NN
cord-010604-3d37o05y	159	43	;	;	:
cord-010604-3d37o05y	159	44	GSK	GSK	NNP
cord-010604-3d37o05y	159	45	,	,	,
cord-010604-3d37o05y	159	46	glycogen	glycogen	NN
cord-010604-3d37o05y	159	47	synthase	synthase	NN
cord-010604-3d37o05y	159	48	kinase	kinase	NN
cord-010604-3d37o05y	159	49	;	;	:
cord-010604-3d37o05y	159	50	HPA	HPA	NNP
cord-010604-3d37o05y	159	51	axis	axis	NN
cord-010604-3d37o05y	159	52	,	,	,
cord-010604-3d37o05y	159	53	hypothalamic	hypothalamic	JJ
cord-010604-3d37o05y	159	54	-	-	HYPH
cord-010604-3d37o05y	159	55	pituitary	pituitary	NN
cord-010604-3d37o05y	159	56	-	-	HYPH
cord-010604-3d37o05y	159	57	adrenocortical	adrenocortical	JJ
cord-010604-3d37o05y	159	58	axis	axis	NN
cord-010604-3d37o05y	159	59	;	;	:
cord-010604-3d37o05y	159	60	IκB	iκb	NN
cord-010604-3d37o05y	159	61	,	,	,
cord-010604-3d37o05y	159	62	inhibitor	inhibitor	NN
cord-010604-3d37o05y	159	63	of	of	IN
cord-010604-3d37o05y	159	64	κB	κb	CD
cord-010604-3d37o05y	159	65	;	;	:
cord-010604-3d37o05y	159	66	IKK	IKK	NNP
cord-010604-3d37o05y	159	67	,	,	,
cord-010604-3d37o05y	159	68	kinase	kinase	NN
cord-010604-3d37o05y	159	69	of	of	IN
cord-010604-3d37o05y	159	70	IκB	iκb	NN
cord-010604-3d37o05y	159	71	;	;	:
cord-010604-3d37o05y	159	72	MAPK	MAPK	NNP
cord-010604-3d37o05y	159	73	,	,	,
cord-010604-3d37o05y	159	74	mitogen	mitogen	NN
cord-010604-3d37o05y	159	75	-	-	HYPH
cord-010604-3d37o05y	159	76	activated	activate	VBN
cord-010604-3d37o05y	159	77	protein	protein	NN
cord-010604-3d37o05y	159	78	kinase	kinase	NN
cord-010604-3d37o05y	159	79	;	;	:
cord-010604-3d37o05y	160	1	NFκB	nfκb	JJ
cord-010604-3d37o05y	160	2	,	,	,
cord-010604-3d37o05y	160	3	nuclear	nuclear	JJ
cord-010604-3d37o05y	160	4	factor	factor	NN
cord-010604-3d37o05y	160	5	kappa	kappa	NN
cord-010604-3d37o05y	160	6	B	B	NNP
cord-010604-3d37o05y	160	7	;	;	:
cord-010604-3d37o05y	161	1	NFAT	NFAT	NNP
cord-010604-3d37o05y	161	2	,	,	,
cord-010604-3d37o05y	161	3	nuclear	nuclear	JJ
cord-010604-3d37o05y	161	4	factor	factor	NN
cord-010604-3d37o05y	161	5	of	of	IN
cord-010604-3d37o05y	161	6	activated	activate	VBN
cord-010604-3d37o05y	161	7	T	t	NN
cord-010604-3d37o05y	161	8	cells	cell	NNS
cord-010604-3d37o05y	161	9	;	;	:
cord-010604-3d37o05y	161	10	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	161	11	,	,	,
cord-010604-3d37o05y	162	1	pleckstrin	pleckstrin	NNP
cord-010604-3d37o05y	162	2	homology	homology	NN
cord-010604-3d37o05y	162	3	domain	domain	NN
cord-010604-3d37o05y	162	4	leucine	leucine	NN
cord-010604-3d37o05y	162	5	-	-	HYPH
cord-010604-3d37o05y	162	6	rich	rich	JJ
cord-010604-3d37o05y	162	7	repeat	repeat	NN
cord-010604-3d37o05y	162	8	protein	protein	NN
cord-010604-3d37o05y	162	9	phosphatase	phosphatase	NN
cord-010604-3d37o05y	162	10	;	;	:
cord-010604-3d37o05y	162	11	PP2A	pp2a	NN
cord-010604-3d37o05y	162	12	,	,	,
cord-010604-3d37o05y	162	13	protein	protein	NN
cord-010604-3d37o05y	162	14	phosphatase	phosphatase	NN
cord-010604-3d37o05y	162	15	2A	2a	CD
cord-010604-3d37o05y	162	16	;	;	:
cord-010604-3d37o05y	162	17	PPARγ	PPARγ	NNS
cord-010604-3d37o05y	162	18	,	,	,
cord-010604-3d37o05y	162	19	peroxisome	peroxisome	NN
cord-010604-3d37o05y	162	20	proliferator	proliferator	NN
cord-010604-3d37o05y	162	21	-	-	HYPH
cord-010604-3d37o05y	162	22	activated	activate	VBN
cord-010604-3d37o05y	162	23	receptor	receptor	NN
cord-010604-3d37o05y	162	24	-	-	HYPH
cord-010604-3d37o05y	162	25	γ	γ	NN
cord-010604-3d37o05y	162	26	;	;	:
cord-010604-3d37o05y	162	27	PTM	PTM	NNP
cord-010604-3d37o05y	162	28	,	,	,
cord-010604-3d37o05y	162	29	post	post	JJ
cord-010604-3d37o05y	162	30	-	-	JJ
cord-010604-3d37o05y	162	31	translational	translational	JJ
cord-010604-3d37o05y	162	32	modification	modification	NN
cord-010604-3d37o05y	162	33	;	;	:
cord-010604-3d37o05y	162	34	RIP1	rip1	NN
cord-010604-3d37o05y	162	35	,	,	,
cord-010604-3d37o05y	162	36	receptor	receptor	NN
cord-010604-3d37o05y	162	37	-	-	HYPH
cord-010604-3d37o05y	162	38	interacting	interact	VBG
cord-010604-3d37o05y	162	39	protein	protein	NN
cord-010604-3d37o05y	162	40	1	1	CD
cord-010604-3d37o05y	162	41	;	;	:
cord-010604-3d37o05y	162	42	SCF	SCF	NNP
cord-010604-3d37o05y	162	43	,	,	,
cord-010604-3d37o05y	162	44	Skp1-CUL1-F	skp1-cul1-f	JJ
cord-010604-3d37o05y	162	45	-	-	HYPH
cord-010604-3d37o05y	162	46	box	box	NN
cord-010604-3d37o05y	162	47	protein	protein	NN
cord-010604-3d37o05y	162	48	;	;	:
cord-010604-3d37o05y	162	49	SKP2	SKP2	NNP
cord-010604-3d37o05y	162	50	,	,	,
cord-010604-3d37o05y	162	51	S	s	NN
cord-010604-3d37o05y	162	52	-	-	HYPH
cord-010604-3d37o05y	162	53	phase	phase	NN
cord-010604-3d37o05y	162	54	kinase	kinase	NN
cord-010604-3d37o05y	162	55	-	-	HYPH
cord-010604-3d37o05y	162	56	associated	associate	VBN
cord-010604-3d37o05y	162	57	protein	protein	NN
cord-010604-3d37o05y	162	58	2	2	CD
cord-010604-3d37o05y	162	59	;	;	:
cord-010604-3d37o05y	162	60	TNF	TNF	NNP
cord-010604-3d37o05y	162	61	,	,	,
cord-010604-3d37o05y	162	62	tumor	tumor	NN
cord-010604-3d37o05y	162	63	necrosis	necrosis	NN
cord-010604-3d37o05y	162	64	factor	factor	NN
cord-010604-3d37o05y	162	65	;	;	:
cord-010604-3d37o05y	162	66	TRAF	TRAF	NNP
cord-010604-3d37o05y	162	67	,	,	,
cord-010604-3d37o05y	162	68	TNF	TNF	NNP
cord-010604-3d37o05y	162	69	receptor	receptor	NN
cord-010604-3d37o05y	162	70	-	-	HYPH
cord-010604-3d37o05y	162	71	associated	associate	VBN
cord-010604-3d37o05y	162	72	factor	factor	NN
cord-010604-3d37o05y	162	73	;	;	:
cord-010604-3d37o05y	162	74	USP	USP	NNP
cord-010604-3d37o05y	162	75	,	,	,
cord-010604-3d37o05y	162	76	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	162	77	-	-	HYPH
cord-010604-3d37o05y	162	78	specific	specific	JJ
cord-010604-3d37o05y	162	79	peptidase	peptidase	NN
cord-010604-3d37o05y	162	80	.	.	.
cord-010604-3d37o05y	163	1	The	the	DT
cord-010604-3d37o05y	163	2	corticotropin	corticotropin	NN
cord-010604-3d37o05y	163	3	-	-	HYPH
cord-010604-3d37o05y	163	4	releasing	release	VBG
cord-010604-3d37o05y	163	5	factor	factor	NN
cord-010604-3d37o05y	163	6	family	family	NN
cord-010604-3d37o05y	163	7	:	:	:
cord-010604-3d37o05y	163	8	physiology	physiology	NN
cord-010604-3d37o05y	163	9	of	of	IN
cord-010604-3d37o05y	163	10	the	the	DT
cord-010604-3d37o05y	163	11	stress	stress	NN
cord-010604-3d37o05y	163	12	response	response	NN
cord-010604-3d37o05y	163	13	Molecular	molecular	JJ
cord-010604-3d37o05y	163	14	pathways	pathway	NNS
cord-010604-3d37o05y	163	15	:	:	:
cord-010604-3d37o05y	163	16	beta	beta	NN
cord-010604-3d37o05y	163	17	-	-	HYPH
cord-010604-3d37o05y	163	18	adrenergic	adrenergic	NN
cord-010604-3d37o05y	163	19	signaling	signaling	NN
cord-010604-3d37o05y	163	20	in	in	IN
cord-010604-3d37o05y	163	21	cancer	cancer	NN
cord-010604-3d37o05y	163	22	Principles	principle	NNS
cord-010604-3d37o05y	163	23	of	of	IN
cord-010604-3d37o05y	163	24	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	163	25	-	-	HYPH
cord-010604-3d37o05y	163	26	dependent	dependent	JJ
cord-010604-3d37o05y	163	27	signaling	signal	VBG
cord-010604-3d37o05y	163	28	Orchestrating	orchestrate	VBG
cord-010604-3d37o05y	163	29	the	the	DT
cord-010604-3d37o05y	163	30	proteome	proteome	NN
cord-010604-3d37o05y	163	31	with	with	IN
cord-010604-3d37o05y	163	32	post	post	JJ
cord-010604-3d37o05y	163	33	-	-	JJ
cord-010604-3d37o05y	163	34	translational	translational	JJ
cord-010604-3d37o05y	163	35	modifications	modification	NNS
cord-010604-3d37o05y	164	1	Adaptive	adaptive	JJ
cord-010604-3d37o05y	164	2	posttranslational	posttranslational	JJ
cord-010604-3d37o05y	164	3	control	control	NN
cord-010604-3d37o05y	164	4	in	in	IN
cord-010604-3d37o05y	164	5	cellular	cellular	JJ
cord-010604-3d37o05y	164	6	stress	stress	NN
cord-010604-3d37o05y	164	7	response	response	NN
cord-010604-3d37o05y	164	8	pathways	pathway	NNS
cord-010604-3d37o05y	164	9	and	and	CC
cord-010604-3d37o05y	164	10	its	-PRON-	PRP$
cord-010604-3d37o05y	164	11	relationship	relationship	NN
cord-010604-3d37o05y	164	12	to	to	IN
cord-010604-3d37o05y	164	13	toxicity	toxicity	NN
cord-010604-3d37o05y	164	14	testing	testing	NN
cord-010604-3d37o05y	164	15	and	and	CC
cord-010604-3d37o05y	164	16	safety	safety	NN
cord-010604-3d37o05y	164	17	assessment	assessment	NN
cord-010604-3d37o05y	164	18	Mechanisms	Mechanisms	NNPS
cord-010604-3d37o05y	164	19	of	of	IN
cord-010604-3d37o05y	164	20	stress	stress	NN
cord-010604-3d37o05y	164	21	in	in	IN
cord-010604-3d37o05y	164	22	the	the	DT
cord-010604-3d37o05y	164	23	brain	brain	NN
cord-010604-3d37o05y	164	24	Post	post	JJ
cord-010604-3d37o05y	164	25	-	-	JJ
cord-010604-3d37o05y	164	26	translational	translational	JJ
cord-010604-3d37o05y	164	27	modifications	modification	NNS
cord-010604-3d37o05y	164	28	of	of	IN
cord-010604-3d37o05y	164	29	the	the	DT
cord-010604-3d37o05y	164	30	mineralocorticoid	mineralocorticoid	NN
cord-010604-3d37o05y	164	31	receptor	receptor	NN
cord-010604-3d37o05y	164	32	:	:	:
cord-010604-3d37o05y	164	33	how	how	WRB
cord-010604-3d37o05y	164	34	to	to	TO
cord-010604-3d37o05y	164	35	dress	dress	VB
cord-010604-3d37o05y	164	36	the	the	DT
cord-010604-3d37o05y	164	37	receptor	receptor	NN
cord-010604-3d37o05y	164	38	according	accord	VBG
cord-010604-3d37o05y	164	39	to	to	IN
cord-010604-3d37o05y	164	40	the	the	DT
cord-010604-3d37o05y	164	41	circumstances	circumstance	NNS
cord-010604-3d37o05y	164	42	?	?	.
cord-010604-3d37o05y	165	1	Role	role	NN
cord-010604-3d37o05y	165	2	of	of	IN
cord-010604-3d37o05y	165	3	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	165	4	in	in	IN
cord-010604-3d37o05y	165	5	the	the	DT
cord-010604-3d37o05y	165	6	modulation	modulation	NN
cord-010604-3d37o05y	165	7	of	of	IN
cord-010604-3d37o05y	165	8	the	the	DT
cord-010604-3d37o05y	165	9	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	165	10	receptor	receptor	NN
cord-010604-3d37o05y	165	11	's	's	POS
cord-010604-3d37o05y	165	12	intrinsically	intrinsically	RB
cord-010604-3d37o05y	165	13	disordered	disordered	JJ
cord-010604-3d37o05y	165	14	domain	domain	NN
cord-010604-3d37o05y	165	15	Glucocorticoid	Glucocorticoid	NNP
cord-010604-3d37o05y	165	16	receptor	receptor	NN
cord-010604-3d37o05y	165	17	control	control	NN
cord-010604-3d37o05y	165	18	of	of	IN
cord-010604-3d37o05y	165	19	transcription	transcription	NN
cord-010604-3d37o05y	165	20	:	:	:
cord-010604-3d37o05y	165	21	precision	precision	NN
cord-010604-3d37o05y	165	22	and	and	CC
cord-010604-3d37o05y	165	23	plasticity	plasticity	NN
cord-010604-3d37o05y	165	24	via	via	IN
cord-010604-3d37o05y	165	25	allostery	allostery	NN
cord-010604-3d37o05y	165	26	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	165	27	and	and	CC
cord-010604-3d37o05y	165	28	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	166	1	in	in	IN
cord-010604-3d37o05y	166	2	signaling	signal	VBG
cord-010604-3d37o05y	166	3	and	and	CC
cord-010604-3d37o05y	166	4	disease	disease	NN
cord-010604-3d37o05y	166	5	FK506	FK506	NNP
cord-010604-3d37o05y	166	6	binding	bind	VBG
cord-010604-3d37o05y	166	7	protein	protein	NN
cord-010604-3d37o05y	166	8	51	51	CD
cord-010604-3d37o05y	166	9	integrates	integrate	VBZ
cord-010604-3d37o05y	166	10	pathways	pathway	NNS
cord-010604-3d37o05y	166	11	of	of	IN
cord-010604-3d37o05y	166	12	adaptation	adaptation	NN
cord-010604-3d37o05y	166	13	:	:	:
cord-010604-3d37o05y	167	1	FKBP51	fkbp51	RB
cord-010604-3d37o05y	167	2	shapes	shape	VBZ
cord-010604-3d37o05y	167	3	the	the	DT
cord-010604-3d37o05y	167	4	reactivity	reactivity	NN
cord-010604-3d37o05y	167	5	to	to	IN
cord-010604-3d37o05y	167	6	environmental	environmental	JJ
cord-010604-3d37o05y	167	7	change	change	NN
cord-010604-3d37o05y	168	1	The	the	DT
cord-010604-3d37o05y	168	2	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	168	3	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	168	4	receptor	receptor	NN
cord-010604-3d37o05y	168	5	co	co	NN
cord-010604-3d37o05y	168	6	-	-	NN
cord-010604-3d37o05y	168	7	chaperone	chaperone	NN
cord-010604-3d37o05y	168	8	:	:	:
cord-010604-3d37o05y	168	9	regulation	regulation	NN
cord-010604-3d37o05y	168	10	,	,	,
cord-010604-3d37o05y	168	11	function	function	NN
cord-010604-3d37o05y	168	12	,	,	,
cord-010604-3d37o05y	168	13	and	and	CC
cord-010604-3d37o05y	168	14	implications	implication	NNS
cord-010604-3d37o05y	168	15	in	in	IN
cord-010604-3d37o05y	168	16	health	health	NN
cord-010604-3d37o05y	168	17	and	and	CC
cord-010604-3d37o05y	168	18	disease	disease	NN
cord-010604-3d37o05y	169	1	The	the	DT
cord-010604-3d37o05y	169	2	many	many	JJ
cord-010604-3d37o05y	169	3	faces	face	NNS
cord-010604-3d37o05y	169	4	of	of	IN
cord-010604-3d37o05y	169	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	169	6	Hsp90	Hsp90	NNP
cord-010604-3d37o05y	169	7	and	and	CC
cord-010604-3d37o05y	169	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	169	9	:	:	:
cord-010604-3d37o05y	169	10	complex	complex	JJ
cord-010604-3d37o05y	169	11	regulators	regulator	NNS
cord-010604-3d37o05y	169	12	of	of	IN
cord-010604-3d37o05y	169	13	psychiatric	psychiatric	JJ
cord-010604-3d37o05y	169	14	diseases	disease	NNS
cord-010604-3d37o05y	169	15	Biological	biological	JJ
cord-010604-3d37o05y	169	16	actions	action	NNS
cord-010604-3d37o05y	169	17	of	of	IN
cord-010604-3d37o05y	169	18	the	the	DT
cord-010604-3d37o05y	169	19	Hsp90-binding	hsp90-binding	NN
cord-010604-3d37o05y	169	20	immunophilins	immunophilin	NNS
cord-010604-3d37o05y	170	1	FKBP51	fkbp51	VB
cord-010604-3d37o05y	170	2	and	and	CC
cord-010604-3d37o05y	171	1	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	171	2	FK506-binding	fk506-binding	NN
cord-010604-3d37o05y	171	3	proteins	protein	NNS
cord-010604-3d37o05y	171	4	51	51	CD
cord-010604-3d37o05y	171	5	and	and	CC
cord-010604-3d37o05y	171	6	52	52	CD
cord-010604-3d37o05y	171	7	differentially	differentially	RB
cord-010604-3d37o05y	171	8	regulate	regulate	VBP
cord-010604-3d37o05y	171	9	dynein	dynein	JJ
cord-010604-3d37o05y	171	10	interaction	interaction	NN
cord-010604-3d37o05y	171	11	and	and	CC
cord-010604-3d37o05y	171	12	nuclear	nuclear	JJ
cord-010604-3d37o05y	171	13	translocation	translocation	NN
cord-010604-3d37o05y	171	14	of	of	IN
cord-010604-3d37o05y	171	15	the	the	DT
cord-010604-3d37o05y	171	16	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	171	17	receptor	receptor	NN
cord-010604-3d37o05y	171	18	in	in	IN
cord-010604-3d37o05y	171	19	mammalian	mammalian	JJ
cord-010604-3d37o05y	171	20	cells	cell	NNS
cord-010604-3d37o05y	172	1	The	the	DT
cord-010604-3d37o05y	173	1	Hsp90-binding	hsp90-binding	NN
cord-010604-3d37o05y	173	2	peptidylprolyl	peptidylprolyl	JJ
cord-010604-3d37o05y	173	3	isomerase	isomerase	NN
cord-010604-3d37o05y	173	4	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	173	5	potentiates	potentiate	VBZ
cord-010604-3d37o05y	173	6	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	173	7	signaling	signal	VBG
cord-010604-3d37o05y	173	8	in	in	IN
cord-010604-3d37o05y	174	1	vivo	vivo	NNP
cord-010604-3d37o05y	174	2	Squirrel	Squirrel	NNP
cord-010604-3d37o05y	174	3	monkey	monkey	NN
cord-010604-3d37o05y	174	4	immunophilin	immunophilin	NNP
cord-010604-3d37o05y	174	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	174	6	is	be	VBZ
cord-010604-3d37o05y	174	7	a	a	DT
cord-010604-3d37o05y	174	8	potent	potent	JJ
cord-010604-3d37o05y	174	9	inhibitor	inhibitor	NN
cord-010604-3d37o05y	174	10	of	of	IN
cord-010604-3d37o05y	174	11	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	174	12	receptor	receptor	NN
cord-010604-3d37o05y	174	13	binding	bind	VBG
cord-010604-3d37o05y	174	14	Overexpression	Overexpression	NNP
cord-010604-3d37o05y	174	15	of	of	IN
cord-010604-3d37o05y	174	16	the	the	DT
cord-010604-3d37o05y	174	17	FK506-binding	fk506-binding	NN
cord-010604-3d37o05y	174	18	immunophilin	immunophilin	NNP
cord-010604-3d37o05y	175	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	175	2	is	be	VBZ
cord-010604-3d37o05y	175	3	the	the	DT
cord-010604-3d37o05y	175	4	common	common	JJ
cord-010604-3d37o05y	175	5	cause	cause	NN
cord-010604-3d37o05y	175	6	of	of	IN
cord-010604-3d37o05y	175	7	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	175	8	resistance	resistance	NN
cord-010604-3d37o05y	175	9	in	in	IN
cord-010604-3d37o05y	175	10	three	three	CD
cord-010604-3d37o05y	175	11	New	New	NNP
cord-010604-3d37o05y	175	12	World	World	NNP
cord-010604-3d37o05y	175	13	primates	primate	NNS
cord-010604-3d37o05y	175	14	Functional	functional	JJ
cord-010604-3d37o05y	175	15	analysis	analysis	NN
cord-010604-3d37o05y	175	16	of	of	IN
cord-010604-3d37o05y	175	17	the	the	DT
cord-010604-3d37o05y	175	18	Hsp90-associated	hsp90-associate	VBN
cord-010604-3d37o05y	175	19	human	human	NNP
cord-010604-3d37o05y	175	20	peptidyl	peptidyl	NNP
cord-010604-3d37o05y	175	21	prolyl	prolyl	NNP
cord-010604-3d37o05y	175	22	cis	cis	NNP
cord-010604-3d37o05y	175	23	/	/	SYM
cord-010604-3d37o05y	175	24	trans	trans	NNP
cord-010604-3d37o05y	176	1	isomerases	isomerases	NNP
cord-010604-3d37o05y	176	2	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	176	3	,	,	,
cord-010604-3d37o05y	176	4	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	176	5	and	and	CC
cord-010604-3d37o05y	176	6	Cyp40	Cyp40	NNP
cord-010604-3d37o05y	176	7	2020	2020	CD
cord-010604-3d37o05y	176	8	)	)	-RRB-
cord-010604-3d37o05y	177	1	Peptidylprolylisomerases	Peptidylprolylisomerases	NNP
cord-010604-3d37o05y	177	2	,	,	,
cord-010604-3d37o05y	177	3	protein	protein	NN
cord-010604-3d37o05y	177	4	folders	folder	NNS
cord-010604-3d37o05y	177	5	or	or	CC
cord-010604-3d37o05y	177	6	scaffolders	scaffolder	NNS
cord-010604-3d37o05y	177	7	?	?	.
cord-010604-3d37o05y	178	1	The	the	DT
cord-010604-3d37o05y	178	2	example	example	NN
cord-010604-3d37o05y	178	3	of	of	IN
cord-010604-3d37o05y	178	4	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	178	5	and	and	CC
cord-010604-3d37o05y	178	6	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	178	7	Tissue	tissue	NN
cord-010604-3d37o05y	178	8	distribution	distribution	NN
cord-010604-3d37o05y	178	9	and	and	CC
cord-010604-3d37o05y	178	10	abundance	abundance	NN
cord-010604-3d37o05y	178	11	of	of	IN
cord-010604-3d37o05y	178	12	human	human	JJ
cord-010604-3d37o05y	178	13	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	178	14	,	,	,
cord-010604-3d37o05y	178	15	and	and	CC
cord-010604-3d37o05y	178	16	FK506-binding	fk506-binde	VBG
cord-010604-3d37o05y	178	17	protein	protein	NN
cord-010604-3d37o05y	178	18	that	that	WDT
cord-010604-3d37o05y	178	19	can	can	MD
cord-010604-3d37o05y	178	20	mediate	mediate	VB
cord-010604-3d37o05y	178	21	calcineurin	calcineurin	JJ
cord-010604-3d37o05y	178	22	inhibition	inhibition	NN
cord-010604-3d37o05y	178	23	Isolation	isolation	NN
cord-010604-3d37o05y	178	24	and	and	CC
cord-010604-3d37o05y	178	25	characterization	characterization	NN
cord-010604-3d37o05y	178	26	of	of	IN
cord-010604-3d37o05y	178	27	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	178	28	-	-	HYPH
cord-010604-3d37o05y	178	29	and	and	CC
cord-010604-3d37o05y	178	30	cyclic	cyclic	JJ
cord-010604-3d37o05y	178	31	AMP	amp	NN
cord-010604-3d37o05y	178	32	-	-	HYPH
cord-010604-3d37o05y	178	33	induced	induce	VBN
cord-010604-3d37o05y	178	34	genes	gene	NNS
cord-010604-3d37o05y	178	35	in	in	IN
cord-010604-3d37o05y	178	36	T	t	NN
cord-010604-3d37o05y	178	37	lymphocytes	lymphocyte	NNS
cord-010604-3d37o05y	178	38	Intronic	Intronic	VBN
cord-010604-3d37o05y	178	39	hormone	hormone	NN
cord-010604-3d37o05y	178	40	response	response	NN
cord-010604-3d37o05y	178	41	elements	element	NNS
cord-010604-3d37o05y	178	42	mediate	mediate	VBP
cord-010604-3d37o05y	178	43	regulation	regulation	NN
cord-010604-3d37o05y	178	44	of	of	IN
cord-010604-3d37o05y	178	45	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	178	46	by	by	IN
cord-010604-3d37o05y	178	47	progestins	progestin	NNS
cord-010604-3d37o05y	178	48	and	and	CC
cord-010604-3d37o05y	178	49	glucocorticoids	glucocorticoid	NNS
cord-010604-3d37o05y	178	50	Glucocorticoid	Glucocorticoid	NNP
cord-010604-3d37o05y	178	51	-	-	HYPH
cord-010604-3d37o05y	178	52	resistant	resistant	JJ
cord-010604-3d37o05y	178	53	B	b	NN
cord-010604-3d37o05y	178	54	-	-	HYPH
cord-010604-3d37o05y	178	55	lymphoblast	lymphoblast	NN
cord-010604-3d37o05y	178	56	cell	cell	NN
cord-010604-3d37o05y	178	57	line	line	NN
cord-010604-3d37o05y	178	58	derived	derive	VBN
cord-010604-3d37o05y	178	59	from	from	IN
cord-010604-3d37o05y	178	60	the	the	DT
cord-010604-3d37o05y	178	61	Bolivian	bolivian	JJ
cord-010604-3d37o05y	178	62	squirrel	squirrel	NN
cord-010604-3d37o05y	178	63	monkey	monkey	NN
cord-010604-3d37o05y	179	1	(	(	-LRB-
cord-010604-3d37o05y	179	2	Saimiri	Saimiri	NNP
cord-010604-3d37o05y	179	3	boliviensis	boliviensis	NNP
cord-010604-3d37o05y	179	4	boliviensis	boliviensis	NNP
cord-010604-3d37o05y	179	5	)	)	-RRB-
cord-010604-3d37o05y	180	1	Allele	allele	NN
cord-010604-3d37o05y	180	2	-	-	HYPH
cord-010604-3d37o05y	180	3	specific	specific	JJ
cord-010604-3d37o05y	180	4	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	180	5	DNA	dna	NN
cord-010604-3d37o05y	180	6	demethylation	demethylation	NN
cord-010604-3d37o05y	180	7	mediates	mediate	VBZ
cord-010604-3d37o05y	180	8	gene	gene	NN
cord-010604-3d37o05y	180	9	-	-	HYPH
cord-010604-3d37o05y	180	10	childhood	childhood	NN
cord-010604-3d37o05y	180	11	trauma	trauma	NN
cord-010604-3d37o05y	180	12	interactions	interaction	NNS
cord-010604-3d37o05y	181	1	Glucocorticoid	glucocorticoid	JJ
cord-010604-3d37o05y	181	2	receptor	receptor	NN
cord-010604-3d37o05y	181	3	activates	activate	VBZ
cord-010604-3d37o05y	181	4	poised	poise	VBN
cord-010604-3d37o05y	181	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	181	6	locus	locus	NN
cord-010604-3d37o05y	181	7	through	through	IN
cord-010604-3d37o05y	181	8	long	long	JJ
cord-010604-3d37o05y	181	9	-	-	HYPH
cord-010604-3d37o05y	181	10	distance	distance	NN
cord-010604-3d37o05y	181	11	interactions	interaction	NNS
cord-010604-3d37o05y	182	1	Glucocorticoid	glucocorticoid	JJ
cord-010604-3d37o05y	182	2	hormone	hormone	NN
cord-010604-3d37o05y	182	3	resistance	resistance	NN
cord-010604-3d37o05y	182	4	during	during	IN
cord-010604-3d37o05y	182	5	primate	primate	JJ
cord-010604-3d37o05y	182	6	evolution	evolution	NN
cord-010604-3d37o05y	182	7	:	:	:
cord-010604-3d37o05y	182	8	receptor	receptor	NN
cord-010604-3d37o05y	182	9	-	-	HYPH
cord-010604-3d37o05y	182	10	mediated	mediate	VBN
cord-010604-3d37o05y	182	11	mechanisms	mechanism	NNS
cord-010604-3d37o05y	183	1	The	the	DT
cord-010604-3d37o05y	183	2	new	new	JJ
cord-010604-3d37o05y	183	3	world	world	NN
cord-010604-3d37o05y	183	4	primates	primate	NNS
cord-010604-3d37o05y	183	5	as	as	IN
cord-010604-3d37o05y	183	6	animal	animal	NN
cord-010604-3d37o05y	183	7	models	model	NNS
cord-010604-3d37o05y	183	8	of	of	IN
cord-010604-3d37o05y	183	9	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	183	10	resistance	resistance	NN
cord-010604-3d37o05y	184	1	The	the	DT
cord-010604-3d37o05y	184	2	corticosteroid	corticosteroid	NN
cord-010604-3d37o05y	184	3	receptor	receptor	NN
cord-010604-3d37o05y	184	4	hypothesis	hypothesis	NN
cord-010604-3d37o05y	184	5	of	of	IN
cord-010604-3d37o05y	184	6	depression	depression	NN
cord-010604-3d37o05y	184	7	Polymorphisms	Polymorphisms	NNP
cord-010604-3d37o05y	184	8	in	in	IN
cord-010604-3d37o05y	184	9	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	184	10	are	be	VBP
cord-010604-3d37o05y	184	11	associated	associate	VBN
cord-010604-3d37o05y	184	12	with	with	IN
cord-010604-3d37o05y	184	13	increased	increase	VBN
cord-010604-3d37o05y	184	14	recurrence	recurrence	NN
cord-010604-3d37o05y	184	15	of	of	IN
cord-010604-3d37o05y	184	16	depressive	depressive	JJ
cord-010604-3d37o05y	184	17	episodes	episode	NNS
cord-010604-3d37o05y	184	18	and	and	CC
cord-010604-3d37o05y	184	19	rapid	rapid	JJ
cord-010604-3d37o05y	184	20	response	response	NN
cord-010604-3d37o05y	184	21	to	to	IN
cord-010604-3d37o05y	184	22	antidepressant	antidepressant	JJ
cord-010604-3d37o05y	184	23	treatment	treatment	NN
cord-010604-3d37o05y	184	24	Posttranslational	Posttranslational	NNP
cord-010604-3d37o05y	184	25	modifications	modification	NNS
cord-010604-3d37o05y	185	1	The	the	DT
cord-010604-3d37o05y	185	2	roles	role	NNS
cord-010604-3d37o05y	185	3	of	of	IN
cord-010604-3d37o05y	185	4	post	post	JJ
cord-010604-3d37o05y	185	5	-	-	JJ
cord-010604-3d37o05y	185	6	translational	translational	JJ
cord-010604-3d37o05y	185	7	modifications	modification	NNS
cord-010604-3d37o05y	185	8	in	in	IN
cord-010604-3d37o05y	185	9	the	the	DT
cord-010604-3d37o05y	185	10	context	context	NN
cord-010604-3d37o05y	185	11	of	of	IN
cord-010604-3d37o05y	185	12	protein	protein	NN
cord-010604-3d37o05y	185	13	interaction	interaction	NN
cord-010604-3d37o05y	185	14	networks	network	NNS
cord-010604-3d37o05y	186	1	Post	post	JJ
cord-010604-3d37o05y	186	2	-	-	JJ
cord-010604-3d37o05y	186	3	translational	translational	JJ
cord-010604-3d37o05y	186	4	modifications	modification	NNS
cord-010604-3d37o05y	186	5	in	in	IN
cord-010604-3d37o05y	186	6	signal	signal	NN
cord-010604-3d37o05y	186	7	integration	integration	NN
cord-010604-3d37o05y	186	8	Uniprot	Uniprot	NNP
cord-010604-3d37o05y	186	9	:	:	:
cord-010604-3d37o05y	186	10	the	the	DT
cord-010604-3d37o05y	186	11	universal	universal	NNP
cord-010604-3d37o05y	186	12	protein	protein	NNP
cord-010604-3d37o05y	186	13	knowledgebase	knowledgebase	NNP
cord-010604-3d37o05y	186	14	Conversion	Conversion	NNP
cord-010604-3d37o05y	186	15	of	of	IN
cord-010604-3d37o05y	186	16	phosphorylase	phosphorylase	NNP
cord-010604-3d37o05y	186	17	b	b	NNP
cord-010604-3d37o05y	186	18	to	to	IN
cord-010604-3d37o05y	186	19	phosphorylase	phosphorylase	NN
cord-010604-3d37o05y	186	20	a	a	DT
cord-010604-3d37o05y	186	21	in	in	IN
cord-010604-3d37o05y	187	1	muscle	muscle	NNP
cord-010604-3d37o05y	187	2	extracts	extract	VBZ
cord-010604-3d37o05y	187	3	Protein	protein	NN
cord-010604-3d37o05y	187	4	-	-	HYPH
cord-010604-3d37o05y	187	5	tyrosine	tyrosine	NN
cord-010604-3d37o05y	187	6	kinases	kinase	NNS
cord-010604-3d37o05y	187	7	Exploring	explore	VBG
cord-010604-3d37o05y	187	8	the	the	DT
cord-010604-3d37o05y	187	9	function	function	NN
cord-010604-3d37o05y	187	10	of	of	IN
cord-010604-3d37o05y	187	11	dynamic	dynamic	JJ
cord-010604-3d37o05y	187	12	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	187	13	-	-	HYPH
cord-010604-3d37o05y	187	14	dephosphorylation	dephosphorylation	NN
cord-010604-3d37o05y	187	15	cycles	cycle	NNS
cord-010604-3d37o05y	188	1	Evolution	evolution	NN
cord-010604-3d37o05y	188	2	of	of	IN
cord-010604-3d37o05y	188	3	protein	protein	NN
cord-010604-3d37o05y	188	4	kinase	kinase	NN
cord-010604-3d37o05y	188	5	signaling	signal	VBG
cord-010604-3d37o05y	188	6	from	from	IN
cord-010604-3d37o05y	188	7	yeast	yeast	NN
cord-010604-3d37o05y	188	8	to	to	TO
cord-010604-3d37o05y	188	9	man	man	VB
cord-010604-3d37o05y	188	10	Regulation	regulation	NN
cord-010604-3d37o05y	188	11	of	of	IN
cord-010604-3d37o05y	188	12	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	188	13	and	and	CC
cord-010604-3d37o05y	188	14	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	188	15	functions	function	NNS
cord-010604-3d37o05y	188	16	by	by	IN
cord-010604-3d37o05y	188	17	post	post	JJ
cord-010604-3d37o05y	188	18	-	-	JJ
cord-010604-3d37o05y	188	19	translational	translational	JJ
cord-010604-3d37o05y	188	20	modifications	modification	NNS
cord-010604-3d37o05y	188	21	Molecular	molecular	JJ
cord-010604-3d37o05y	188	22	cloning	clone	VBG
cord-010604-3d37o05y	188	23	of	of	IN
cord-010604-3d37o05y	188	24	human	human	JJ
cord-010604-3d37o05y	188	25	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	188	26	and	and	CC
cord-010604-3d37o05y	188	27	comparisons	comparison	NNS
cord-010604-3d37o05y	188	28	of	of	IN
cord-010604-3d37o05y	188	29	immunophilin	immunophilin	NN
cord-010604-3d37o05y	188	30	interactions	interaction	NNS
cord-010604-3d37o05y	188	31	with	with	IN
cord-010604-3d37o05y	188	32	Hsp90	Hsp90	NNP
cord-010604-3d37o05y	188	33	and	and	CC
cord-010604-3d37o05y	188	34	progesterone	progesterone	NN
cord-010604-3d37o05y	188	35	receptor	receptor	NN
cord-010604-3d37o05y	188	36	The	the	DT
cord-010604-3d37o05y	188	37	90-kDa	90-kda	CD
cord-010604-3d37o05y	188	38	heat	heat	NN
cord-010604-3d37o05y	188	39	-	-	HYPH
cord-010604-3d37o05y	188	40	shock	shock	NN
cord-010604-3d37o05y	188	41	protein	protein	NN
cord-010604-3d37o05y	188	42	(	(	-LRB-
cord-010604-3d37o05y	188	43	Hsp90)-binding	Hsp90)-binding	NNP
cord-010604-3d37o05y	188	44	immunophilin	immunophilin	XX
cord-010604-3d37o05y	189	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	189	2	is	be	VBZ
cord-010604-3d37o05y	189	3	a	a	DT
cord-010604-3d37o05y	189	4	mitochondrial	mitochondrial	JJ
cord-010604-3d37o05y	189	5	protein	protein	NN
cord-010604-3d37o05y	189	6	that	that	WDT
cord-010604-3d37o05y	189	7	translocates	translocate	VBZ
cord-010604-3d37o05y	189	8	to	to	IN
cord-010604-3d37o05y	189	9	the	the	DT
cord-010604-3d37o05y	189	10	nucleus	nucleus	NN
cord-010604-3d37o05y	189	11	to	to	TO
cord-010604-3d37o05y	189	12	protect	protect	VB
cord-010604-3d37o05y	189	13	cells	cell	NNS
cord-010604-3d37o05y	189	14	against	against	IN
cord-010604-3d37o05y	189	15	oxidative	oxidative	JJ
cord-010604-3d37o05y	189	16	stress	stress	NN
cord-010604-3d37o05y	189	17	Pink1	Pink1	NNP
cord-010604-3d37o05y	190	1	regulates	regulate	VBZ
cord-010604-3d37o05y	190	2	FKBP5	FKBP5	NNPS
cord-010604-3d37o05y	190	3	interaction	interaction	NN
cord-010604-3d37o05y	190	4	with	with	IN
cord-010604-3d37o05y	190	5	AKT	AKT	NNP
cord-010604-3d37o05y	190	6	/	/	SYM
cord-010604-3d37o05y	190	7	PHLPP	PHLPP	NNP
cord-010604-3d37o05y	190	8	and	and	CC
cord-010604-3d37o05y	190	9	protects	protect	VBZ
cord-010604-3d37o05y	190	10	neurons	neuron	NNS
cord-010604-3d37o05y	190	11	from	from	IN
cord-010604-3d37o05y	190	12	neurotoxin	neurotoxin	NN
cord-010604-3d37o05y	190	13	stress	stress	NN
cord-010604-3d37o05y	190	14	induced	induce	VBN
cord-010604-3d37o05y	190	15	by	by	IN
cord-010604-3d37o05y	190	16	MPP	MPP	NNP
cord-010604-3d37o05y	190	17	+	+	CC
cord-010604-3d37o05y	190	18	Regulation	regulation	NN
cord-010604-3d37o05y	190	19	of	of	IN
cord-010604-3d37o05y	190	20	serine	serine	NN
cord-010604-3d37o05y	190	21	-	-	HYPH
cord-010604-3d37o05y	190	22	threonine	threonine	NN
cord-010604-3d37o05y	190	23	kinase	kinase	NN
cord-010604-3d37o05y	190	24	Akt	Akt	NNP
cord-010604-3d37o05y	190	25	activation	activation	NN
cord-010604-3d37o05y	190	26	by	by	IN
cord-010604-3d37o05y	190	27	NAD(+)-dependent	NAD(+)-dependent	NNP
cord-010604-3d37o05y	190	28	deacetylase	deacetylase	NN
cord-010604-3d37o05y	190	29	SIRT7	sirt7	NN
cord-010604-3d37o05y	190	30	.	.	.
cord-010604-3d37o05y	191	1	Cell	cell	NN
cord-010604-3d37o05y	191	2	Rep	Rep	NNP
cord-010604-3d37o05y	192	1	The	the	DT
cord-010604-3d37o05y	192	2	activity	activity	NN
cord-010604-3d37o05y	192	3	of	of	IN
cord-010604-3d37o05y	192	4	the	the	DT
cord-010604-3d37o05y	192	5	glucocorticoid	glucocorticoid	NN
cord-010604-3d37o05y	192	6	receptor	receptor	NN
cord-010604-3d37o05y	192	7	is	be	VBZ
cord-010604-3d37o05y	192	8	regulated	regulate	VBN
cord-010604-3d37o05y	192	9	by	by	IN
cord-010604-3d37o05y	192	10	SUMO	SUMO	NNP
cord-010604-3d37o05y	192	11	conjugation	conjugation	NN
cord-010604-3d37o05y	192	12	to	to	IN
cord-010604-3d37o05y	192	13	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	192	14	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	192	15	,	,	,
cord-010604-3d37o05y	192	16	a	a	DT
cord-010604-3d37o05y	192	17	novel	novel	JJ
cord-010604-3d37o05y	192	18	T	t	NN
cord-010604-3d37o05y	192	19	-	-	HYPH
cord-010604-3d37o05y	192	20	cell	cell	NN
cord-010604-3d37o05y	192	21	-	-	HYPH
cord-010604-3d37o05y	192	22	specific	specific	JJ
cord-010604-3d37o05y	192	23	immunophilin	immunophilin	NN
cord-010604-3d37o05y	192	24	capable	capable	JJ
cord-010604-3d37o05y	192	25	of	of	IN
cord-010604-3d37o05y	192	26	calcineurin	calcineurin	NNP
cord-010604-3d37o05y	192	27	inhibition	inhibition	NN
cord-010604-3d37o05y	192	28	Comparative	Comparative	NNP
cord-010604-3d37o05y	192	29	analysis	analysis	NN
cord-010604-3d37o05y	192	30	of	of	IN
cord-010604-3d37o05y	192	31	calcineurin	calcineurin	JJ
cord-010604-3d37o05y	192	32	inhibition	inhibition	NN
cord-010604-3d37o05y	192	33	by	by	IN
cord-010604-3d37o05y	192	34	complexes	complex	NNS
cord-010604-3d37o05y	192	35	of	of	IN
cord-010604-3d37o05y	192	36	immunosuppressive	immunosuppressive	JJ
cord-010604-3d37o05y	192	37	drugs	drug	NNS
cord-010604-3d37o05y	192	38	with	with	IN
cord-010604-3d37o05y	192	39	human	human	JJ
cord-010604-3d37o05y	192	40	FK506	fk506	NN
cord-010604-3d37o05y	192	41	binding	bind	VBG
cord-010604-3d37o05y	192	42	proteins	protein	NNS
cord-010604-3d37o05y	192	43	Calcium	calcium	NN
cord-010604-3d37o05y	192	44	-	-	HYPH
cord-010604-3d37o05y	192	45	and	and	CC
cord-010604-3d37o05y	192	46	FK506-independent	fk506-independent	NN
cord-010604-3d37o05y	192	47	interaction	interaction	NN
cord-010604-3d37o05y	192	48	between	between	IN
cord-010604-3d37o05y	192	49	the	the	DT
cord-010604-3d37o05y	192	50	immunophilin	immunophilin	NNP
cord-010604-3d37o05y	192	51	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	192	52	and	and	CC
cord-010604-3d37o05y	192	53	calcineurin	calcineurin	NNP
cord-010604-3d37o05y	192	54	Overexpression	Overexpression	NNP
cord-010604-3d37o05y	192	55	of	of	IN
cord-010604-3d37o05y	192	56	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	192	57	in	in	IN
cord-010604-3d37o05y	192	58	idiopathic	idiopathic	JJ
cord-010604-3d37o05y	192	59	myelofibrosis	myelofibrosis	NN
cord-010604-3d37o05y	192	60	regulates	regulate	VBZ
cord-010604-3d37o05y	192	61	the	the	DT
cord-010604-3d37o05y	192	62	growth	growth	NN
cord-010604-3d37o05y	192	63	factor	factor	NN
cord-010604-3d37o05y	192	64	independence	independence	NN
cord-010604-3d37o05y	192	65	of	of	IN
cord-010604-3d37o05y	192	66	megakaryocyte	megakaryocyte	NNP
cord-010604-3d37o05y	192	67	progenitors	progenitor	NNS
cord-010604-3d37o05y	192	68	Regulation	Regulation	NNP
cord-010604-3d37o05y	192	69	and	and	CC
cord-010604-3d37o05y	192	70	function	function	NN
cord-010604-3d37o05y	192	71	of	of	IN
cord-010604-3d37o05y	192	72	IKK	IKK	NNP
cord-010604-3d37o05y	192	73	and	and	CC
cord-010604-3d37o05y	192	74	IKK	IKK	NNP
cord-010604-3d37o05y	192	75	-	-	HYPH
cord-010604-3d37o05y	192	76	related	relate	VBN
cord-010604-3d37o05y	192	77	kinases	kinase	NNS
cord-010604-3d37o05y	193	1	A	a	DT
cord-010604-3d37o05y	193	2	physical	physical	JJ
cord-010604-3d37o05y	193	3	and	and	CC
cord-010604-3d37o05y	193	4	functional	functional	JJ
cord-010604-3d37o05y	193	5	map	map	NN
cord-010604-3d37o05y	193	6	of	of	IN
cord-010604-3d37o05y	194	1	the	the	DT
cord-010604-3d37o05y	194	2	human	human	JJ
cord-010604-3d37o05y	194	3	TNF	TNF	NNP
cord-010604-3d37o05y	194	4	-	-	HYPH
cord-010604-3d37o05y	194	5	α/	α/	NNP
cord-010604-3d37o05y	194	6	NF	NF	NNP
cord-010604-3d37o05y	194	7	-	-	HYPH
cord-010604-3d37o05y	194	8	κB	κb	CD
cord-010604-3d37o05y	194	9	signal	signal	NN
cord-010604-3d37o05y	194	10	transduction	transduction	NN
cord-010604-3d37o05y	194	11	pathway	pathway	NN
cord-010604-3d37o05y	194	12	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	194	13	employs	employ	VBZ
cord-010604-3d37o05y	194	14	both	both	DT
cord-010604-3d37o05y	194	15	scaffold	scaffold	NN
cord-010604-3d37o05y	194	16	and	and	CC
cord-010604-3d37o05y	194	17	isomerase	isomerase	NN
cord-010604-3d37o05y	194	18	functions	function	NNS
cord-010604-3d37o05y	194	19	to	to	TO
cord-010604-3d37o05y	194	20	promote	promote	VB
cord-010604-3d37o05y	194	21	NF	NF	NNP
cord-010604-3d37o05y	194	22	-	-	HYPH
cord-010604-3d37o05y	194	23	κB	κb	CD
cord-010604-3d37o05y	194	24	activation	activation	NN
cord-010604-3d37o05y	194	25	in	in	IN
cord-010604-3d37o05y	194	26	melanoma	melanoma	NN
cord-010604-3d37o05y	194	27	Regulation	regulation	NN
cord-010604-3d37o05y	194	28	of	of	IN
cord-010604-3d37o05y	194	29	the	the	DT
cord-010604-3d37o05y	194	30	NF	nf	NN
cord-010604-3d37o05y	194	31	-	-	HYPH
cord-010604-3d37o05y	194	32	κB	κB	NNP
cord-010604-3d37o05y	194	33	-	-	HYPH
cord-010604-3d37o05y	194	34	inducing	induce	VBG
cord-010604-3d37o05y	194	35	kinase	kinase	NN
cord-010604-3d37o05y	194	36	by	by	IN
cord-010604-3d37o05y	194	37	tumor	tumor	NN
cord-010604-3d37o05y	194	38	necrosis	necrosis	NN
cord-010604-3d37o05y	194	39	factor	factor	NN
cord-010604-3d37o05y	194	40	receptor	receptor	NN
cord-010604-3d37o05y	194	41	-	-	HYPH
cord-010604-3d37o05y	194	42	associated	associate	VBN
cord-010604-3d37o05y	194	43	factor	factor	NN
cord-010604-3d37o05y	194	44	3-induced	3-induced	CD
cord-010604-3d37o05y	194	45	degradation	degradation	NN
cord-010604-3d37o05y	194	46	NF	nf	NN
cord-010604-3d37o05y	194	47	-	-	HYPH
cord-010604-3d37o05y	194	48	κB	κB	NNP
cord-010604-3d37o05y	194	49	-	-	HYPH
cord-010604-3d37o05y	194	50	inducing	induce	VBG
cord-010604-3d37o05y	194	51	kinase	kinase	NN
cord-010604-3d37o05y	194	52	and	and	CC
cord-010604-3d37o05y	194	53	IκB	iκb	NN
cord-010604-3d37o05y	194	54	kinase	kinase	NNS
cord-010604-3d37o05y	194	55	participate	participate	VBP
cord-010604-3d37o05y	194	56	in	in	IN
cord-010604-3d37o05y	194	57	human	human	JJ
cord-010604-3d37o05y	194	58	T	t	NN
cord-010604-3d37o05y	194	59	-	-	HYPH
cord-010604-3d37o05y	194	60	cell	cell	NN
cord-010604-3d37o05y	194	61	leukemia	leukemia	NN
cord-010604-3d37o05y	194	62	virus	virus	NN
cord-010604-3d37o05y	195	1	I	I	NNP
cord-010604-3d37o05y	195	2	Tax	tax	NN
cord-010604-3d37o05y	195	3	-	-	HYPH
cord-010604-3d37o05y	195	4	mediated	mediate	VBN
cord-010604-3d37o05y	195	5	NF	nf	NN
cord-010604-3d37o05y	195	6	-	-	HYPH
cord-010604-3d37o05y	195	7	κB	κb	CD
cord-010604-3d37o05y	195	8	activation	activation	NN
cord-010604-3d37o05y	196	1	AKTivation	aktivation	NN
cord-010604-3d37o05y	196	2	mechanisms	mechanism	NNS
cord-010604-3d37o05y	197	1	The	the	DT
cord-010604-3d37o05y	197	2	PI3	pi3	NN
cord-010604-3d37o05y	197	3	K	K	NNP
cord-010604-3d37o05y	197	4	pathway	pathway	NN
cord-010604-3d37o05y	197	5	in	in	IN
cord-010604-3d37o05y	197	6	human	human	JJ
cord-010604-3d37o05y	197	7	disease	disease	NN
cord-010604-3d37o05y	197	8	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	197	9	affects	affect	VBZ
cord-010604-3d37o05y	197	10	cancer	cancer	NN
cord-010604-3d37o05y	197	11	cell	cell	NN
cord-010604-3d37o05y	197	12	response	response	NN
cord-010604-3d37o05y	197	13	to	to	IN
cord-010604-3d37o05y	197	14	chemotherapy	chemotherapy	NN
cord-010604-3d37o05y	197	15	by	by	IN
cord-010604-3d37o05y	197	16	negatively	negatively	RB
cord-010604-3d37o05y	197	17	regulating	regulate	VBG
cord-010604-3d37o05y	197	18	Akt	Akt	NNP
cord-010604-3d37o05y	197	19	Association	Association	NNP
cord-010604-3d37o05y	197	20	of	of	IN
cord-010604-3d37o05y	197	21	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	197	22	with	with	IN
cord-010604-3d37o05y	197	23	priming	priming	NN
cord-010604-3d37o05y	197	24	of	of	IN
cord-010604-3d37o05y	197	25	autophagy	autophagy	NN
cord-010604-3d37o05y	197	26	pathways	pathway	NNS
cord-010604-3d37o05y	197	27	and	and	CC
cord-010604-3d37o05y	197	28	mediation	mediation	NN
cord-010604-3d37o05y	197	29	of	of	IN
cord-010604-3d37o05y	197	30	antidepressant	antidepressant	JJ
cord-010604-3d37o05y	197	31	treatment	treatment	NN
cord-010604-3d37o05y	197	32	response	response	NN
cord-010604-3d37o05y	197	33	:	:	:
cord-010604-3d37o05y	197	34	evidence	evidence	NN
cord-010604-3d37o05y	197	35	in	in	IN
cord-010604-3d37o05y	197	36	cells	cell	NNS
cord-010604-3d37o05y	197	37	,	,	,
cord-010604-3d37o05y	197	38	mice	mouse	NNS
cord-010604-3d37o05y	197	39	,	,	,
cord-010604-3d37o05y	197	40	and	and	CC
cord-010604-3d37o05y	197	41	humans	human	NNS
cord-010604-3d37o05y	197	42	AKT	AKT	NNP
cord-010604-3d37o05y	197	43	/	/	SYM
cord-010604-3d37o05y	197	44	PKB	PKB	NNP
cord-010604-3d37o05y	197	45	signaling	signal	VBG
cord-010604-3d37o05y	197	46	:	:	:
cord-010604-3d37o05y	197	47	navigating	navigate	VBG
cord-010604-3d37o05y	197	48	downstream	downstream	JJ
cord-010604-3d37o05y	197	49	Role	role	NN
cord-010604-3d37o05y	197	50	of	of	IN
cord-010604-3d37o05y	197	51	FK506-binding	fk506-binde	VBG
cord-010604-3d37o05y	197	52	protein	protein	NN
cord-010604-3d37o05y	197	53	51	51	CD
cord-010604-3d37o05y	197	54	in	in	IN
cord-010604-3d37o05y	197	55	the	the	DT
cord-010604-3d37o05y	197	56	control	control	NN
cord-010604-3d37o05y	197	57	of	of	IN
cord-010604-3d37o05y	197	58	apoptosis	apoptosis	NN
cord-010604-3d37o05y	197	59	of	of	IN
cord-010604-3d37o05y	197	60	irradiated	irradiate	VBN
cord-010604-3d37o05y	197	61	melanoma	melanoma	NN
cord-010604-3d37o05y	197	62	cells	cell	NNS
cord-010604-3d37o05y	197	63	Hsp90-binding	hsp90-binde	VBG
cord-010604-3d37o05y	198	1	immunophilin	immunophilin	NNP
cord-010604-3d37o05y	198	2	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	198	3	forms	form	VBZ
cord-010604-3d37o05y	198	4	complexes	complex	NNS
cord-010604-3d37o05y	198	5	with	with	IN
cord-010604-3d37o05y	198	6	hTERT	htert	JJ
cord-010604-3d37o05y	198	7	enhancing	enhance	VBG
cord-010604-3d37o05y	198	8	telomerase	telomerase	NN
cord-010604-3d37o05y	198	9	activity	activity	NN
cord-010604-3d37o05y	198	10	Fkbp51	Fkbp51	NNP
cord-010604-3d37o05y	198	11	immunohistochemical	immunohistochemical	JJ
cord-010604-3d37o05y	198	12	expression	expression	NN
cord-010604-3d37o05y	198	13	:	:	:
cord-010604-3d37o05y	198	14	a	a	DT
cord-010604-3d37o05y	198	15	new	new	JJ
cord-010604-3d37o05y	198	16	prognostic	prognostic	JJ
cord-010604-3d37o05y	198	17	biomarker	biomarker	NN
cord-010604-3d37o05y	198	18	for	for	IN
cord-010604-3d37o05y	198	19	OSCC	OSCC	NNP
cord-010604-3d37o05y	198	20	?	?	.
cord-010604-3d37o05y	199	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	199	2	controls	control	VBZ
cord-010604-3d37o05y	199	3	cellular	cellular	JJ
cord-010604-3d37o05y	199	4	adipogenesis	adipogenesis	NN
cord-010604-3d37o05y	199	5	through	through	IN
cord-010604-3d37o05y	199	6	p38	p38	CD
cord-010604-3d37o05y	199	7	kinase	kinase	NN
cord-010604-3d37o05y	199	8	-	-	HYPH
cord-010604-3d37o05y	199	9	mediated	mediate	VBN
cord-010604-3d37o05y	199	10	phosphorylation	phosphorylation	NN
cord-010604-3d37o05y	199	11	of	of	IN
cord-010604-3d37o05y	199	12	GRα	GRα	NNS
cord-010604-3d37o05y	199	13	and	and	CC
cord-010604-3d37o05y	199	14	PPARν	PPARν	NNS
cord-010604-3d37o05y	199	15	FKBP5	FKBP5	NNS
cord-010604-3d37o05y	199	16	/	/	SYM
cord-010604-3d37o05y	199	17	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	200	1	enhances	enhance	VBZ
cord-010604-3d37o05y	200	2	autophagy	autophagy	NN
cord-010604-3d37o05y	200	3	to	to	TO
cord-010604-3d37o05y	200	4	synergize	synergize	VB
cord-010604-3d37o05y	200	5	with	with	IN
cord-010604-3d37o05y	200	6	antidepressant	antidepressant	JJ
cord-010604-3d37o05y	200	7	action	action	NN
cord-010604-3d37o05y	200	8	SKP2	SKP2	NNP
cord-010604-3d37o05y	201	1	attenuates	attenuate	VBZ
cord-010604-3d37o05y	201	2	autophagy	autophagy	NN
cord-010604-3d37o05y	201	3	through	through	IN
cord-010604-3d37o05y	201	4	Beclin1-ubiquitination	Beclin1-ubiquitination	NNP
cord-010604-3d37o05y	201	5	and	and	CC
cord-010604-3d37o05y	201	6	its	-PRON-	PRP$
cord-010604-3d37o05y	201	7	inhibition	inhibition	NN
cord-010604-3d37o05y	201	8	reduces	reduce	VBZ
cord-010604-3d37o05y	202	1	MERS	MERS	NNP
cord-010604-3d37o05y	202	2	-	-	HYPH
cord-010604-3d37o05y	202	3	Coronavirus	Coronavirus	NNP
cord-010604-3d37o05y	202	4	infection	infection	NN
cord-010604-3d37o05y	202	5	Inhibition	inhibition	NN
cord-010604-3d37o05y	202	6	of	of	IN
cord-010604-3d37o05y	202	7	glycogen	glycogen	NN
cord-010604-3d37o05y	202	8	synthase	synthase	NN
cord-010604-3d37o05y	202	9	kinase-3	kinase-3	NNP
cord-010604-3d37o05y	202	10	by	by	IN
cord-010604-3d37o05y	202	11	insulin	insulin	NN
cord-010604-3d37o05y	202	12	mediated	mediate	VBN
cord-010604-3d37o05y	202	13	by	by	IN
cord-010604-3d37o05y	202	14	protein	protein	NN
cord-010604-3d37o05y	202	15	kinase	kinase	NN
cord-010604-3d37o05y	202	16	B	B	NNP
cord-010604-3d37o05y	202	17	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	202	18	inhibits	inhibit	VBZ
cord-010604-3d37o05y	202	19	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	202	20	and	and	CC
cord-010604-3d37o05y	202	21	augments	augment	VBZ
cord-010604-3d37o05y	202	22	the	the	DT
cord-010604-3d37o05y	202	23	effects	effect	NNS
cord-010604-3d37o05y	202	24	of	of	IN
cord-010604-3d37o05y	202	25	distinct	distinct	JJ
cord-010604-3d37o05y	202	26	psychotropic	psychotropic	JJ
cord-010604-3d37o05y	202	27	medications	medication	NNS
cord-010604-3d37o05y	202	28	Mice	mouse	NNS
cord-010604-3d37o05y	202	29	lacking	lack	VBG
cord-010604-3d37o05y	203	1	phosphatase	phosphatase	NNP
cord-010604-3d37o05y	203	2	PP2A	PP2A	NNP
cord-010604-3d37o05y	204	1	subunit	subunit	NNP
cord-010604-3d37o05y	204	2	PR61	PR61	NNP
cord-010604-3d37o05y	204	3	/	/	SYM
cord-010604-3d37o05y	204	4	B	b	NN
cord-010604-3d37o05y	204	5	0	0	CD
cord-010604-3d37o05y	204	6	δ	δ	NN
cord-010604-3d37o05y	204	7	(	(	-LRB-
cord-010604-3d37o05y	204	8	Ppp2r5d	ppp2r5d	CD
cord-010604-3d37o05y	204	9	)	)	-RRB-
cord-010604-3d37o05y	204	10	develop	develop	VB
cord-010604-3d37o05y	204	11	spatially	spatially	RB
cord-010604-3d37o05y	204	12	restricted	restrict	VBN
cord-010604-3d37o05y	204	13	tauopathy	tauopathy	NN
cord-010604-3d37o05y	204	14	by	by	IN
cord-010604-3d37o05y	204	15	deregulation	deregulation	NN
cord-010604-3d37o05y	204	16	of	of	IN
cord-010604-3d37o05y	204	17	CDK5	CDK5	NNP
cord-010604-3d37o05y	204	18	and	and	CC
cord-010604-3d37o05y	204	19	GSK3β	GSK3β	NNP
cord-010604-3d37o05y	204	20	Chaperoning	Chaperoning	NNP
cord-010604-3d37o05y	204	21	epigenetics	epigenetic	VBZ
cord-010604-3d37o05y	204	22	:	:	:
cord-010604-3d37o05y	205	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	205	2	decreases	decrease	VBZ
cord-010604-3d37o05y	205	3	the	the	DT
cord-010604-3d37o05y	205	4	activity	activity	NN
cord-010604-3d37o05y	205	5	of	of	IN
cord-010604-3d37o05y	205	6	DNMT1	DNMT1	NNS
cord-010604-3d37o05y	205	7	and	and	CC
cord-010604-3d37o05y	205	8	mediates	mediate	VBZ
cord-010604-3d37o05y	205	9	epigenetic	epigenetic	JJ
cord-010604-3d37o05y	205	10	effects	effect	NNS
cord-010604-3d37o05y	205	11	of	of	IN
cord-010604-3d37o05y	205	12	the	the	DT
cord-010604-3d37o05y	205	13	antidepressant	antidepressant	NN
cord-010604-3d37o05y	206	1	paroxetine	paroxetine	NNP
cord-010604-3d37o05y	206	2	Stress	Stress	NNP
cord-010604-3d37o05y	206	3	-	-	HYPH
cord-010604-3d37o05y	206	4	responsive	responsive	JJ
cord-010604-3d37o05y	206	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	206	6	regulates	regulate	VBZ
cord-010604-3d37o05y	206	7	AKT2-AS160	akt2-as160	NN
cord-010604-3d37o05y	206	8	signaling	signal	VBG
cord-010604-3d37o05y	206	9	and	and	CC
cord-010604-3d37o05y	206	10	metabolic	metabolic	JJ
cord-010604-3d37o05y	206	11	function	function	NN
cord-010604-3d37o05y	207	1	The	the	DT
cord-010604-3d37o05y	207	2	Hsp90	Hsp90	NNP
cord-010604-3d37o05y	207	3	cochaperone	cochaperone	NN
cord-010604-3d37o05y	207	4	,	,	,
cord-010604-3d37o05y	207	5	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	207	6	,	,	,
cord-010604-3d37o05y	207	7	increases	increase	VBZ
cord-010604-3d37o05y	207	8	Tau	Tau	NNP
cord-010604-3d37o05y	207	9	stability	stability	NN
cord-010604-3d37o05y	207	10	and	and	CC
cord-010604-3d37o05y	207	11	polymerizes	polymerizes	NN
cord-010604-3d37o05y	207	12	microtubules	microtubule	VBZ
cord-010604-3d37o05y	207	13	Organization	organization	NN
cord-010604-3d37o05y	207	14	and	and	CC
cord-010604-3d37o05y	207	15	function	function	NN
cord-010604-3d37o05y	207	16	of	of	IN
cord-010604-3d37o05y	207	17	the	the	DT
cord-010604-3d37o05y	207	18	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	207	19	and	and	CC
cord-010604-3d37o05y	207	20	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	207	21	genes	gene	NNS
cord-010604-3d37o05y	207	22	Bending	bend	VBG
cord-010604-3d37o05y	207	23	tau	tau	NN
cord-010604-3d37o05y	207	24	into	into	IN
cord-010604-3d37o05y	207	25	shape	shape	NN
cord-010604-3d37o05y	207	26	:	:	:
cord-010604-3d37o05y	207	27	the	the	DT
cord-010604-3d37o05y	207	28	emerging	emerge	VBG
cord-010604-3d37o05y	207	29	role	role	NN
cord-010604-3d37o05y	207	30	of	of	IN
cord-010604-3d37o05y	207	31	peptidyl	peptidyl	JJ
cord-010604-3d37o05y	207	32	-	-	HYPH
cord-010604-3d37o05y	207	33	prolyl	prolyl	VBN
cord-010604-3d37o05y	207	34	isomerases	isomerase	NNS
cord-010604-3d37o05y	207	35	in	in	IN
cord-010604-3d37o05y	207	36	tauopathies	tauopathies	NNP
cord-010604-3d37o05y	208	1	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	208	2	regulates	regulate	VBZ
cord-010604-3d37o05y	208	3	cell	cell	NN
cord-010604-3d37o05y	208	4	motility	motility	NN
cord-010604-3d37o05y	208	5	and	and	CC
cord-010604-3d37o05y	208	6	invasion	invasion	NN
cord-010604-3d37o05y	208	7	via	via	IN
cord-010604-3d37o05y	208	8	RhoA	RhoA	NNP
cord-010604-3d37o05y	208	9	signaling	signal	VBG
cord-010604-3d37o05y	208	10	RhoA	RhoA	NNP
cord-010604-3d37o05y	208	11	-	-	HYPH
cord-010604-3d37o05y	208	12	ROCK	ROCK	NNP
cord-010604-3d37o05y	208	13	signaling	signal	VBG
cord-010604-3d37o05y	208	14	as	as	IN
cord-010604-3d37o05y	208	15	a	a	DT
cord-010604-3d37o05y	208	16	therapeutic	therapeutic	JJ
cord-010604-3d37o05y	208	17	target	target	NN
cord-010604-3d37o05y	208	18	in	in	IN
cord-010604-3d37o05y	208	19	traumatic	traumatic	JJ
cord-010604-3d37o05y	208	20	brain	brain	NN
cord-010604-3d37o05y	208	21	injury	injury	NN
cord-010604-3d37o05y	209	1	The	the	DT
cord-010604-3d37o05y	209	2	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	209	3	system	system	NN
cord-010604-3d37o05y	209	4	Protein	protein	NN
cord-010604-3d37o05y	209	5	Modifications	modification	NNS
cord-010604-3d37o05y	209	6	:	:	:
cord-010604-3d37o05y	210	1	Beyond	beyond	IN
cord-010604-3d37o05y	210	2	the	the	DT
cord-010604-3d37o05y	210	3	Usual	Usual	NNP
cord-010604-3d37o05y	210	4	Suspects	Suspects	NNPS
cord-010604-3d37o05y	210	5	'	'	POS
cord-010604-3d37o05y	210	6	review	review	NN
cord-010604-3d37o05y	210	7	series	series	NN
cord-010604-3d37o05y	210	8	Cellular	Cellular	NNP
cord-010604-3d37o05y	210	9	quality	quality	NN
cord-010604-3d37o05y	210	10	control	control	NN
cord-010604-3d37o05y	210	11	by	by	IN
cord-010604-3d37o05y	210	12	the	the	DT
cord-010604-3d37o05y	210	13	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	210	14	-	-	HYPH
cord-010604-3d37o05y	210	15	proteasome	proteasome	VBN
cord-010604-3d37o05y	210	16	system	system	NN
cord-010604-3d37o05y	210	17	and	and	CC
cord-010604-3d37o05y	210	18	autophagy	autophagy	NN
cord-010604-3d37o05y	210	19	Accelerated	accelerate	VBN
cord-010604-3d37o05y	210	20	neurodegeneration	neurodegeneration	NN
cord-010604-3d37o05y	210	21	through	through	IN
cord-010604-3d37o05y	210	22	chaperone	chaperone	NN
cord-010604-3d37o05y	210	23	-	-	HYPH
cord-010604-3d37o05y	210	24	mediated	mediate	VBN
cord-010604-3d37o05y	210	25	oligomerization	oligomerization	NN
cord-010604-3d37o05y	210	26	of	of	IN
cord-010604-3d37o05y	210	27	tau	tau	NNP
cord-010604-3d37o05y	210	28	NF	NF	NNP
cord-010604-3d37o05y	210	29	-	-	HYPH
cord-010604-3d37o05y	210	30	κB	κb	CD
cord-010604-3d37o05y	210	31	transcriptional	transcriptional	JJ
cord-010604-3d37o05y	210	32	activity	activity	NN
cord-010604-3d37o05y	210	33	is	be	VBZ
cord-010604-3d37o05y	210	34	modulated	modulate	VBN
cord-010604-3d37o05y	210	35	by	by	IN
cord-010604-3d37o05y	211	1	FK506-binding	fk506-binding	NN
cord-010604-3d37o05y	211	2	proteins	protein	NNS
cord-010604-3d37o05y	211	3	FKBP51	fkbp51	VBP
cord-010604-3d37o05y	211	4	and	and	CC
cord-010604-3d37o05y	211	5	FKBP52	FKBP52	NNP
cord-010604-3d37o05y	212	1	:	:	:
cord-010604-3d37o05y	212	2	a	a	DT
cord-010604-3d37o05y	212	3	role	role	NN
cord-010604-3d37o05y	212	4	for	for	IN
cord-010604-3d37o05y	212	5	peptidyl	peptidyl	NNP
cord-010604-3d37o05y	212	6	-	-	HYPH
cord-010604-3d37o05y	212	7	prolyl	prolyl	JJ
cord-010604-3d37o05y	212	8	isomerase	isomerase	NN
cord-010604-3d37o05y	212	9	activity	activity	NN
cord-010604-3d37o05y	212	10	Mitochondria	mitochondria	NN
cord-010604-3d37o05y	212	11	-	-	HYPH
cord-010604-3d37o05y	212	12	nucleus	nucleus	NN
cord-010604-3d37o05y	212	13	shuttling	shuttle	VBG
cord-010604-3d37o05y	212	14	FK506-binding	fk506-binde	VBG
cord-010604-3d37o05y	212	15	protein	protein	NN
cord-010604-3d37o05y	212	16	51	51	CD
cord-010604-3d37o05y	213	1	interacts	interact	VBZ
cord-010604-3d37o05y	213	2	with	with	IN
cord-010604-3d37o05y	213	3	TRAF	TRAF	NNP
cord-010604-3d37o05y	213	4	proteins	protein	NNS
cord-010604-3d37o05y	213	5	and	and	CC
cord-010604-3d37o05y	213	6	facilitates	facilitate	VBZ
cord-010604-3d37o05y	213	7	the	the	DT
cord-010604-3d37o05y	213	8	RIG	rig	NN
cord-010604-3d37o05y	213	9	-	-	HYPH
cord-010604-3d37o05y	213	10	I	-PRON-	PRP
cord-010604-3d37o05y	213	11	-	-	HYPH
cord-010604-3d37o05y	213	12	like	like	JJ
cord-010604-3d37o05y	213	13	receptor	receptor	NN
cord-010604-3d37o05y	213	14	-	-	HYPH
cord-010604-3d37o05y	213	15	mediated	mediate	VBN
cord-010604-3d37o05y	213	16	expression	expression	NN
cord-010604-3d37o05y	213	17	of	of	IN
cord-010604-3d37o05y	213	18	type	type	NN
cord-010604-3d37o05y	214	1	I	-PRON-	PRP
cord-010604-3d37o05y	214	2	IFN	IFN	NNP
cord-010604-3d37o05y	214	3	FKBP51	FKBP51	NNP
cord-010604-3d37o05y	214	4	and	and	CC
cord-010604-3d37o05y	214	5	FKBP12.6-Novel	fkbp12.6-novel	JJ
cord-010604-3d37o05y	214	6	and	and	CC
cord-010604-3d37o05y	214	7	tight	tight	JJ
cord-010604-3d37o05y	214	8	interactors	interactor	NNS
cord-010604-3d37o05y	214	9	of	of	IN
cord-010604-3d37o05y	214	10	Glomulin	Glomulin	NNP
cord-010604-3d37o05y	214	11	A	a	DT
cord-010604-3d37o05y	214	12	quantitative	quantitative	JJ
cord-010604-3d37o05y	214	13	chaperone	chaperone	NN
cord-010604-3d37o05y	214	14	interaction	interaction	NN
cord-010604-3d37o05y	214	15	network	network	NN
cord-010604-3d37o05y	214	16	reveals	reveal	VBZ
cord-010604-3d37o05y	214	17	the	the	DT
cord-010604-3d37o05y	214	18	architecture	architecture	NN
cord-010604-3d37o05y	214	19	of	of	IN
cord-010604-3d37o05y	214	20	cellular	cellular	JJ
cord-010604-3d37o05y	214	21	protein	protein	NN
cord-010604-3d37o05y	214	22	homeostasis	homeostasis	NN
cord-010604-3d37o05y	214	23	pathways	pathway	NNS
cord-010604-3d37o05y	214	24	USP49	USP49	NNP
cord-010604-3d37o05y	214	25	negatively	negatively	RB
cord-010604-3d37o05y	214	26	regulates	regulate	VBZ
cord-010604-3d37o05y	214	27	tumorigenesis	tumorigenesis	NN
cord-010604-3d37o05y	214	28	and	and	CC
cord-010604-3d37o05y	214	29	chemoresistance	chemoresistance	NN
cord-010604-3d37o05y	214	30	through	through	IN
cord-010604-3d37o05y	214	31	FKBP51-AKT	FKBP51-AKT	NNP
cord-010604-3d37o05y	215	1	signaling	signal	VBG
cord-010604-3d37o05y	215	2	SKP2	SKP2	NNP
cord-010604-3d37o05y	215	3	is	be	VBZ
cord-010604-3d37o05y	215	4	required	require	VBN
cord-010604-3d37o05y	215	5	for	for	IN
cord-010604-3d37o05y	215	6	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	215	7	-	-	HYPH
cord-010604-3d37o05y	215	8	mediated	mediate	VBN
cord-010604-3d37o05y	215	9	degradation	degradation	NN
cord-010604-3d37o05y	215	10	of	of	IN
cord-010604-3d37o05y	215	11	the	the	DT
cord-010604-3d37o05y	215	12	CDK	CDK	NNP
cord-010604-3d37o05y	215	13	inhibitor	inhibitor	NN
cord-010604-3d37o05y	215	14	p27	p27	NN
cord-010604-3d37o05y	215	15	Expression	expression	NN
cord-010604-3d37o05y	215	16	of	of	IN
cord-010604-3d37o05y	215	17	Skp2	Skp2	NNP
cord-010604-3d37o05y	215	18	,	,	,
cord-010604-3d37o05y	215	19	a	a	DT
cord-010604-3d37o05y	215	20	p27(Kip1	p27(kip1	NN
cord-010604-3d37o05y	215	21	)	)	-RRB-
cord-010604-3d37o05y	215	22	ubiquitin	ubiquitin	NN
cord-010604-3d37o05y	215	23	ligase	ligase	NN
cord-010604-3d37o05y	215	24	,	,	,
cord-010604-3d37o05y	215	25	in	in	IN
cord-010604-3d37o05y	215	26	malignant	malignant	JJ
cord-010604-3d37o05y	215	27	lymphoma	lymphoma	NN
cord-010604-3d37o05y	215	28	:	:	:
cord-010604-3d37o05y	215	29	correlation	correlation	NN
cord-010604-3d37o05y	215	30	with	with	IN
cord-010604-3d37o05y	215	31	p27(Kip1	p27(Kip1	NNP
cord-010604-3d37o05y	215	32	)	)	-RRB-
cord-010604-3d37o05y	215	33	and	and	CC
cord-010604-3d37o05y	215	34	proliferation	proliferation	NN
cord-010604-3d37o05y	215	35	index	index	NN
cord-010604-3d37o05y	215	36	Kip1	Kip1	NNP
cord-010604-3d37o05y	215	37	meets	meet	VBZ
cord-010604-3d37o05y	215	38	SKP2	SKP2	NNP
cord-010604-3d37o05y	215	39	:	:	:
cord-010604-3d37o05y	215	40	new	new	JJ
cord-010604-3d37o05y	215	41	links	link	NNS
cord-010604-3d37o05y	215	42	in	in	IN
cord-010604-3d37o05y	215	43	cell	cell	NN
cord-010604-3d37o05y	215	44	-	-	HYPH
cord-010604-3d37o05y	215	45	cycle	cycle	NN
cord-010604-3d37o05y	215	46	control	control	NN
cord-010604-3d37o05y	216	1	Dysregulated	dysregulated	JJ
cord-010604-3d37o05y	216	2	expression	expression	NN
cord-010604-3d37o05y	216	3	of	of	IN
cord-010604-3d37o05y	216	4	SKP2	SKP2	NNP
cord-010604-3d37o05y	216	5	and	and	CC
cord-010604-3d37o05y	216	6	its	-PRON-	PRP$
cord-010604-3d37o05y	216	7	role	role	NN
cord-010604-3d37o05y	216	8	in	in	IN
cord-010604-3d37o05y	216	9	hematological	hematological	JJ
cord-010604-3d37o05y	216	10	malignancies	malignancy	NNS
cord-010604-3d37o05y	216	11	Autophagy	autophagy	NN
cord-010604-3d37o05y	216	12	:	:	:
cord-010604-3d37o05y	216	13	renovation	renovation	NN
cord-010604-3d37o05y	216	14	of	of	IN
cord-010604-3d37o05y	216	15	cells	cell	NNS
cord-010604-3d37o05y	216	16	and	and	CC
cord-010604-3d37o05y	216	17	tissues	tissue	NNS
cord-010604-3d37o05y	216	18	Dynamics	dynamic	NNS
cord-010604-3d37o05y	216	19	and	and	CC
cord-010604-3d37o05y	216	20	diversity	diversity	NN
cord-010604-3d37o05y	216	21	in	in	IN
cord-010604-3d37o05y	216	22	autophagy	autophagy	NN
cord-010604-3d37o05y	216	23	mechanisms	mechanism	NNS
cord-010604-3d37o05y	216	24	:	:	:
cord-010604-3d37o05y	216	25	lessons	lesson	NNS
cord-010604-3d37o05y	216	26	from	from	IN
cord-010604-3d37o05y	216	27	yeast	yeast	NN
cord-010604-3d37o05y	217	1	The	the	DT
cord-010604-3d37o05y	217	2	Atg8	Atg8	NNP
cord-010604-3d37o05y	217	3	conjugation	conjugation	NN
cord-010604-3d37o05y	217	4	system	system	NN
cord-010604-3d37o05y	217	5	is	be	VBZ
cord-010604-3d37o05y	217	6	indispensable	indispensable	JJ
cord-010604-3d37o05y	217	7	for	for	IN
cord-010604-3d37o05y	217	8	proper	proper	JJ
cord-010604-3d37o05y	217	9	development	development	NN
cord-010604-3d37o05y	217	10	of	of	IN
cord-010604-3d37o05y	217	11	autophagic	autophagic	JJ
cord-010604-3d37o05y	217	12	isolation	isolation	NN
cord-010604-3d37o05y	217	13	membranes	membrane	NNS
cord-010604-3d37o05y	217	14	in	in	IN
cord-010604-3d37o05y	217	15	mice	mouse	NNS
cord-010604-3d37o05y	218	1	Atg8	Atg8	NNP
cord-010604-3d37o05y	218	2	controls	control	VBZ
cord-010604-3d37o05y	218	3	phagophore	phagophore	NN
cord-010604-3d37o05y	218	4	expansion	expansion	NN
cord-010604-3d37o05y	218	5	during	during	IN
cord-010604-3d37o05y	218	6	autophagosome	autophagosome	NNP
cord-010604-3d37o05y	218	7	formation	formation	NN
cord-010604-3d37o05y	218	8	ATG	ATG	NNP
cord-010604-3d37o05y	218	9	systems	system	NNS
cord-010604-3d37o05y	218	10	from	from	IN
cord-010604-3d37o05y	218	11	the	the	DT
cord-010604-3d37o05y	218	12	protein	protein	NN
cord-010604-3d37o05y	218	13	structural	structural	JJ
cord-010604-3d37o05y	218	14	point	point	NN
cord-010604-3d37o05y	218	15	of	of	IN
cord-010604-3d37o05y	218	16	view	view	NN