id	sid	tid	token	lemma	pos
cord-000257-ampip7od	1	1	key	key	JJ
cord-000257-ampip7od	2	1	:	:	:
cord-000257-ampip7od	2	2	cord-000257-ampip7od	cord-000257-ampip7od	NFP
cord-000257-ampip7od	2	3	authors	author	NNS
cord-000257-ampip7od	2	4	:	:	:
cord-000257-ampip7od	3	1	Bagowski	Bagowski	NNP
cord-000257-ampip7od	3	2	,	,	,
cord-000257-ampip7od	3	3	Christoph	Christoph	NNP
cord-000257-ampip7od	3	4	P	P	NNP
cord-000257-ampip7od	3	5	;	;	:
cord-000257-ampip7od	3	6	Bruins	Bruins	NNP
cord-000257-ampip7od	3	7	,	,	,
cord-000257-ampip7od	3	8	Wouter	Wouter	NNP
cord-000257-ampip7od	3	9	;	;	:
cord-000257-ampip7od	3	10	te	te	NNP
cord-000257-ampip7od	3	11	Velthuis	Velthuis	NNP
cord-000257-ampip7od	3	12	,	,	,
cord-000257-ampip7od	4	1	Aartjan	Aartjan	NNP
cord-000257-ampip7od	4	2	J.W	J.W	NNP
cord-000257-ampip7od	4	3	title	title	NN
cord-000257-ampip7od	4	4	:	:	:
cord-000257-ampip7od	4	5	The	the	DT
cord-000257-ampip7od	4	6	Nature	Nature	NNP
cord-000257-ampip7od	4	7	of	of	IN
cord-000257-ampip7od	4	8	Protein	Protein	NNP
cord-000257-ampip7od	4	9	Domain	Domain	NNP
cord-000257-ampip7od	4	10	Evolution	evolution	NN
cord-000257-ampip7od	4	11	:	:	:
cord-000257-ampip7od	4	12	Shaping	shape	VBG
cord-000257-ampip7od	4	13	the	the	DT
cord-000257-ampip7od	4	14	Interaction	Interaction	NNP
cord-000257-ampip7od	4	15	Network	Network	NNP
cord-000257-ampip7od	4	16	date	date	NN
cord-000257-ampip7od	4	17	:	:	:
cord-000257-ampip7od	4	18	2010	2010	CD
cord-000257-ampip7od	4	19	-	-	SYM
cord-000257-ampip7od	4	20	08	08	CD
cord-000257-ampip7od	4	21	-	-	SYM
cord-000257-ampip7od	4	22	17	17	CD
cord-000257-ampip7od	4	23	journal	journal	NN
cord-000257-ampip7od	4	24	:	:	:
cord-000257-ampip7od	4	25	Curr	Curr	NNP
cord-000257-ampip7od	4	26	Genomics	Genomics	NNP
cord-000257-ampip7od	4	27	DOI	DOI	NNP
cord-000257-ampip7od	4	28	:	:	:
cord-000257-ampip7od	4	29	10.2174/138920210791616725	10.2174/138920210791616725	CD
cord-000257-ampip7od	4	30	sha	sha	NNP
cord-000257-ampip7od	4	31	:	:	:
cord-000257-ampip7od	4	32	a25045aa52c78b89840287b2cff9d7dffe0bb07f	a25045aa52c78b89840287b2cff9d7dffe0bb07f	NNP
cord-000257-ampip7od	4	33	doc_id	doc_id	NNP
cord-000257-ampip7od	4	34	:	:	:
cord-000257-ampip7od	4	35	257	257	CD
cord-000257-ampip7od	4	36	cord_uid	cord_uid	NNS
cord-000257-ampip7od	4	37	:	:	:
cord-000257-ampip7od	5	1	ampip7od	ampip7od	.
cord-000257-ampip7od	6	1	The	the	DT
cord-000257-ampip7od	6	2	proteomes	proteome	NNS
cord-000257-ampip7od	6	3	that	that	WDT
cord-000257-ampip7od	6	4	make	make	VBP
cord-000257-ampip7od	6	5	up	up	RP
cord-000257-ampip7od	6	6	the	the	DT
cord-000257-ampip7od	6	7	collection	collection	NN
cord-000257-ampip7od	6	8	of	of	IN
cord-000257-ampip7od	6	9	proteins	protein	NNS
cord-000257-ampip7od	6	10	in	in	IN
cord-000257-ampip7od	6	11	contemporary	contemporary	JJ
cord-000257-ampip7od	6	12	organisms	organism	NNS
cord-000257-ampip7od	6	13	evolved	evolve	VBD
cord-000257-ampip7od	6	14	through	through	IN
cord-000257-ampip7od	6	15	recombination	recombination	NN
cord-000257-ampip7od	6	16	and	and	CC
cord-000257-ampip7od	6	17	duplication	duplication	NN
cord-000257-ampip7od	6	18	of	of	IN
cord-000257-ampip7od	6	19	a	a	DT
cord-000257-ampip7od	6	20	limited	limited	JJ
cord-000257-ampip7od	6	21	set	set	NN
cord-000257-ampip7od	6	22	of	of	IN
cord-000257-ampip7od	6	23	domains	domain	NNS
cord-000257-ampip7od	6	24	.	.	.
cord-000257-ampip7od	7	1	These	these	DT
cord-000257-ampip7od	7	2	protein	protein	NN
cord-000257-ampip7od	7	3	domains	domain	NNS
cord-000257-ampip7od	7	4	are	be	VBP
cord-000257-ampip7od	7	5	essentially	essentially	RB
cord-000257-ampip7od	7	6	the	the	DT
cord-000257-ampip7od	7	7	main	main	JJ
cord-000257-ampip7od	7	8	components	component	NNS
cord-000257-ampip7od	7	9	of	of	IN
cord-000257-ampip7od	7	10	globular	globular	JJ
cord-000257-ampip7od	7	11	proteins	protein	NNS
cord-000257-ampip7od	7	12	and	and	CC
cord-000257-ampip7od	7	13	are	be	VBP
cord-000257-ampip7od	7	14	the	the	DT
cord-000257-ampip7od	7	15	most	most	RBS
cord-000257-ampip7od	7	16	principal	principal	JJ
cord-000257-ampip7od	7	17	level	level	NN
cord-000257-ampip7od	7	18	at	at	IN
cord-000257-ampip7od	7	19	which	which	WDT
cord-000257-ampip7od	7	20	protein	protein	NN
cord-000257-ampip7od	7	21	function	function	NN
cord-000257-ampip7od	7	22	and	and	CC
cord-000257-ampip7od	7	23	protein	protein	NN
cord-000257-ampip7od	7	24	interactions	interaction	NNS
cord-000257-ampip7od	7	25	can	can	MD
cord-000257-ampip7od	7	26	be	be	VB
cord-000257-ampip7od	7	27	understood	understand	VBN
cord-000257-ampip7od	7	28	.	.	.
cord-000257-ampip7od	8	1	An	an	DT
cord-000257-ampip7od	8	2	important	important	JJ
cord-000257-ampip7od	8	3	aspect	aspect	NN
cord-000257-ampip7od	8	4	of	of	IN
cord-000257-ampip7od	8	5	domain	domain	NN
cord-000257-ampip7od	8	6	evolution	evolution	NN
cord-000257-ampip7od	8	7	is	be	VBZ
cord-000257-ampip7od	8	8	their	-PRON-	PRP$
cord-000257-ampip7od	8	9	atomic	atomic	JJ
cord-000257-ampip7od	8	10	structure	structure	NN
cord-000257-ampip7od	8	11	and	and	CC
cord-000257-ampip7od	8	12	biochemical	biochemical	JJ
cord-000257-ampip7od	8	13	function	function	NN
cord-000257-ampip7od	8	14	,	,	,
cord-000257-ampip7od	8	15	which	which	WDT
cord-000257-ampip7od	8	16	are	be	VBP
cord-000257-ampip7od	8	17	both	both	DT
cord-000257-ampip7od	8	18	specified	specify	VBN
cord-000257-ampip7od	8	19	by	by	IN
cord-000257-ampip7od	8	20	the	the	DT
cord-000257-ampip7od	8	21	information	information	NN
cord-000257-ampip7od	8	22	in	in	IN
cord-000257-ampip7od	8	23	the	the	DT
cord-000257-ampip7od	8	24	amino	amino	NN
cord-000257-ampip7od	8	25	acid	acid	NN
cord-000257-ampip7od	8	26	sequence	sequence	NN
cord-000257-ampip7od	8	27	.	.	.
cord-000257-ampip7od	9	1	Changes	change	NNS
cord-000257-ampip7od	9	2	in	in	IN
cord-000257-ampip7od	9	3	this	this	DT
cord-000257-ampip7od	9	4	information	information	NN
cord-000257-ampip7od	9	5	may	may	MD
cord-000257-ampip7od	9	6	bring	bring	VB
cord-000257-ampip7od	9	7	about	about	RP
cord-000257-ampip7od	9	8	new	new	JJ
cord-000257-ampip7od	9	9	folds	fold	NNS
cord-000257-ampip7od	9	10	,	,	,
cord-000257-ampip7od	9	11	functions	function	NNS
cord-000257-ampip7od	9	12	and	and	CC
cord-000257-ampip7od	9	13	protein	protein	NN
cord-000257-ampip7od	9	14	architectures	architecture	NNS
cord-000257-ampip7od	9	15	.	.	.
cord-000257-ampip7od	10	1	With	with	IN
cord-000257-ampip7od	10	2	the	the	DT
cord-000257-ampip7od	10	3	present	present	NN
cord-000257-ampip7od	10	4	and	and	CC
cord-000257-ampip7od	10	5	still	still	RB
cord-000257-ampip7od	10	6	increasing	increase	VBG
cord-000257-ampip7od	10	7	wealth	wealth	NN
cord-000257-ampip7od	10	8	of	of	IN
cord-000257-ampip7od	10	9	sequences	sequence	NNS
cord-000257-ampip7od	10	10	and	and	CC
cord-000257-ampip7od	10	11	annotation	annotation	NN
cord-000257-ampip7od	10	12	data	datum	NNS
cord-000257-ampip7od	10	13	brought	bring	VBN
cord-000257-ampip7od	10	14	about	about	RP
cord-000257-ampip7od	10	15	by	by	IN
cord-000257-ampip7od	10	16	genomics	genomic	NNS
cord-000257-ampip7od	10	17	,	,	,
cord-000257-ampip7od	10	18	new	new	JJ
cord-000257-ampip7od	10	19	evolutionary	evolutionary	JJ
cord-000257-ampip7od	10	20	relationships	relationship	NNS
cord-000257-ampip7od	10	21	are	be	VBP
cord-000257-ampip7od	10	22	constantly	constantly	RB
cord-000257-ampip7od	10	23	being	be	VBG
cord-000257-ampip7od	10	24	revealed	reveal	VBN
cord-000257-ampip7od	10	25	,	,	,
cord-000257-ampip7od	10	26	unknown	unknown	JJ
cord-000257-ampip7od	10	27	structures	structure	NNS
cord-000257-ampip7od	10	28	modeled	model	VBN
cord-000257-ampip7od	10	29	and	and	CC
cord-000257-ampip7od	10	30	phylogenies	phylogeny	NNS
cord-000257-ampip7od	10	31	inferred	infer	VBN
cord-000257-ampip7od	10	32	.	.	.
cord-000257-ampip7od	11	1	Such	such	JJ
cord-000257-ampip7od	11	2	investigations	investigation	NNS
cord-000257-ampip7od	11	3	not	not	RB
cord-000257-ampip7od	11	4	only	only	RB
cord-000257-ampip7od	11	5	help	help	VBP
cord-000257-ampip7od	11	6	predict	predict	VB
cord-000257-ampip7od	11	7	the	the	DT
cord-000257-ampip7od	11	8	function	function	NN
cord-000257-ampip7od	11	9	of	of	IN
cord-000257-ampip7od	11	10	newly	newly	RB
cord-000257-ampip7od	11	11	discovered	discover	VBN
cord-000257-ampip7od	11	12	proteins	protein	NNS
cord-000257-ampip7od	11	13	,	,	,
cord-000257-ampip7od	11	14	but	but	CC
cord-000257-ampip7od	11	15	also	also	RB
cord-000257-ampip7od	11	16	assist	assist	VB
cord-000257-ampip7od	11	17	in	in	IN
cord-000257-ampip7od	11	18	mapping	map	VBG
cord-000257-ampip7od	11	19	unforeseen	unforeseen	JJ
cord-000257-ampip7od	11	20	pathways	pathway	NNS
cord-000257-ampip7od	11	21	of	of	IN
cord-000257-ampip7od	11	22	evolution	evolution	NN
cord-000257-ampip7od	11	23	and	and	CC
cord-000257-ampip7od	11	24	reveal	reveal	VB
cord-000257-ampip7od	11	25	crucial	crucial	JJ
cord-000257-ampip7od	11	26	,	,	,
cord-000257-ampip7od	11	27	co	co	JJ
cord-000257-ampip7od	11	28	-	-	JJ
cord-000257-ampip7od	11	29	evolving	evolve	VBG
cord-000257-ampip7od	11	30	inter-	inter-	JJ
cord-000257-ampip7od	11	31	and	and	CC
cord-000257-ampip7od	11	32	intra	intra	JJ
cord-000257-ampip7od	11	33	-	-	JJ
cord-000257-ampip7od	11	34	molecular	molecular	JJ
cord-000257-ampip7od	11	35	interactions	interaction	NNS
cord-000257-ampip7od	11	36	.	.	.
cord-000257-ampip7od	12	1	In	in	IN
cord-000257-ampip7od	12	2	turn	turn	NN
cord-000257-ampip7od	12	3	this	this	DT
cord-000257-ampip7od	12	4	will	will	MD
cord-000257-ampip7od	12	5	help	help	VB
cord-000257-ampip7od	12	6	us	-PRON-	PRP
cord-000257-ampip7od	12	7	describe	describe	VB
cord-000257-ampip7od	12	8	how	how	WRB
cord-000257-ampip7od	12	9	protein	protein	NN
cord-000257-ampip7od	12	10	domains	domain	NNS
cord-000257-ampip7od	12	11	shaped	shape	VBD
cord-000257-ampip7od	12	12	cellular	cellular	JJ
cord-000257-ampip7od	12	13	interaction	interaction	NN
cord-000257-ampip7od	12	14	networks	network	NNS
cord-000257-ampip7od	12	15	and	and	CC
cord-000257-ampip7od	12	16	the	the	DT
cord-000257-ampip7od	12	17	dynamics	dynamic	NNS
cord-000257-ampip7od	12	18	with	with	IN
cord-000257-ampip7od	12	19	which	which	WDT
cord-000257-ampip7od	12	20	they	-PRON-	PRP
cord-000257-ampip7od	12	21	are	be	VBP
cord-000257-ampip7od	12	22	regulated	regulate	VBN
cord-000257-ampip7od	12	23	in	in	IN
cord-000257-ampip7od	12	24	the	the	DT
cord-000257-ampip7od	12	25	cell	cell	NN
cord-000257-ampip7od	12	26	.	.	.
cord-000257-ampip7od	13	1	Additionally	additionally	RB
cord-000257-ampip7od	13	2	,	,	,
cord-000257-ampip7od	13	3	these	these	DT
cord-000257-ampip7od	13	4	studies	study	NNS
cord-000257-ampip7od	13	5	can	can	MD
cord-000257-ampip7od	13	6	be	be	VB
cord-000257-ampip7od	13	7	used	use	VBN
cord-000257-ampip7od	13	8	for	for	IN
cord-000257-ampip7od	13	9	the	the	DT
cord-000257-ampip7od	13	10	design	design	NN
cord-000257-ampip7od	13	11	of	of	IN
cord-000257-ampip7od	13	12	new	new	JJ
cord-000257-ampip7od	13	13	and	and	CC
cord-000257-ampip7od	13	14	optimized	optimized	JJ
cord-000257-ampip7od	13	15	protein	protein	NN
cord-000257-ampip7od	13	16	domains	domain	NNS
cord-000257-ampip7od	13	17	for	for	IN
cord-000257-ampip7od	13	18	therapy	therapy	NN
cord-000257-ampip7od	13	19	.	.	.
cord-000257-ampip7od	14	1	In	in	IN
cord-000257-ampip7od	14	2	this	this	DT
cord-000257-ampip7od	14	3	review	review	NN
cord-000257-ampip7od	14	4	,	,	,
cord-000257-ampip7od	14	5	we	-PRON-	PRP
cord-000257-ampip7od	14	6	aim	aim	VBP
cord-000257-ampip7od	14	7	to	to	TO
cord-000257-ampip7od	14	8	describe	describe	VB
cord-000257-ampip7od	14	9	the	the	DT
cord-000257-ampip7od	14	10	basic	basic	JJ
cord-000257-ampip7od	14	11	concepts	concept	NNS
cord-000257-ampip7od	14	12	of	of	IN
cord-000257-ampip7od	14	13	protein	protein	NN
cord-000257-ampip7od	14	14	domain	domain	NN
cord-000257-ampip7od	14	15	evolution	evolution	NN
cord-000257-ampip7od	14	16	and	and	CC
cord-000257-ampip7od	14	17	illustrate	illustrate	VB
cord-000257-ampip7od	14	18	recent	recent	JJ
cord-000257-ampip7od	14	19	developments	development	NNS
cord-000257-ampip7od	14	20	in	in	IN
cord-000257-ampip7od	14	21	molecular	molecular	JJ
cord-000257-ampip7od	14	22	evolution	evolution	NN
cord-000257-ampip7od	14	23	that	that	WDT
cord-000257-ampip7od	14	24	have	have	VBP
cord-000257-ampip7od	14	25	provided	provide	VBN
cord-000257-ampip7od	14	26	valuable	valuable	JJ
cord-000257-ampip7od	14	27	new	new	JJ
cord-000257-ampip7od	14	28	insights	insight	NNS
cord-000257-ampip7od	14	29	in	in	IN
cord-000257-ampip7od	14	30	the	the	DT
cord-000257-ampip7od	14	31	field	field	NN
cord-000257-ampip7od	14	32	of	of	IN
cord-000257-ampip7od	14	33	comparative	comparative	JJ
cord-000257-ampip7od	14	34	genomics	genomic	NNS
cord-000257-ampip7od	14	35	and	and	CC
cord-000257-ampip7od	14	36	protein	protein	NN
cord-000257-ampip7od	14	37	interaction	interaction	NN
cord-000257-ampip7od	14	38	networks	network	NNS
cord-000257-ampip7od	14	39	.	.	.
cord-000257-ampip7od	15	1	The	the	DT
cord-000257-ampip7od	15	2	protein	protein	NN
cord-000257-ampip7od	15	3	universe	universe	NN
cord-000257-ampip7od	15	4	is	be	VBZ
cord-000257-ampip7od	15	5	the	the	DT
cord-000257-ampip7od	15	6	collection	collection	NN
cord-000257-ampip7od	15	7	of	of	IN
cord-000257-ampip7od	15	8	proteins	protein	NNS
cord-000257-ampip7od	15	9	of	of	IN
cord-000257-ampip7od	15	10	all	all	DT
cord-000257-ampip7od	15	11	biological	biological	JJ
cord-000257-ampip7od	15	12	species	specie	NNS
cord-000257-ampip7od	15	13	that	that	WDT
cord-000257-ampip7od	15	14	exist	exist	VBP
cord-000257-ampip7od	15	15	or	or	CC
cord-000257-ampip7od	15	16	have	have	VBP
cord-000257-ampip7od	15	17	once	once	RB
cord-000257-ampip7od	15	18	existed	exist	VBN
cord-000257-ampip7od	15	19	on	on	IN
cord-000257-ampip7od	15	20	Earth	Earth	NNP
cord-000257-ampip7od	15	21	[	[	-LRB-
cord-000257-ampip7od	15	22	1	1	CD
cord-000257-ampip7od	15	23	]	]	-RRB-
cord-000257-ampip7od	15	24	.	.	.
cord-000257-ampip7od	16	1	Our	-PRON-	PRP$
cord-000257-ampip7od	16	2	sampling	sampling	NN
cord-000257-ampip7od	16	3	and	and	CC
cord-000257-ampip7od	16	4	understanding	understanding	NN
cord-000257-ampip7od	16	5	of	of	IN
cord-000257-ampip7od	16	6	it	-PRON-	PRP
cord-000257-ampip7od	16	7	began	begin	VBD
cord-000257-ampip7od	16	8	over	over	IN
cord-000257-ampip7od	16	9	half	half	PDT
cord-000257-ampip7od	16	10	a	a	DT
cord-000257-ampip7od	16	11	century	century	NN
cord-000257-ampip7od	16	12	ago	ago	RB
cord-000257-ampip7od	16	13	,	,	,
cord-000257-ampip7od	16	14	when	when	WRB
cord-000257-ampip7od	16	15	the	the	DT
cord-000257-ampip7od	16	16	first	first	JJ
cord-000257-ampip7od	16	17	peptide	peptide	NN
cord-000257-ampip7od	16	18	and	and	CC
cord-000257-ampip7od	16	19	protein	protein	NN
cord-000257-ampip7od	16	20	sequences	sequence	NNS
cord-000257-ampip7od	16	21	were	be	VBD
cord-000257-ampip7od	16	22	determined	determine	VBN
cord-000257-ampip7od	16	23	by	by	IN
cord-000257-ampip7od	16	24	Sanger	Sanger	NNP
cord-000257-ampip7od	16	25	[	[	-LRB-
cord-000257-ampip7od	16	26	2	2	CD
cord-000257-ampip7od	16	27	,	,	,
cord-000257-ampip7od	16	28	3	3	CD
cord-000257-ampip7od	16	29	]	]	-RRB-
cord-000257-ampip7od	16	30	and	and	CC
cord-000257-ampip7od	16	31	,	,	,
cord-000257-ampip7od	16	32	subsequently	subsequently	RB
cord-000257-ampip7od	16	33	,	,	,
cord-000257-ampip7od	16	34	the	the	DT
cord-000257-ampip7od	16	35	sequencing	sequencing	NN
cord-000257-ampip7od	16	36	of	of	IN
cord-000257-ampip7od	16	37	RNA	RNA	NNP
cord-000257-ampip7od	16	38	and	and	CC
cord-000257-ampip7od	16	39	DNA	DNA	NNP
cord-000257-ampip7od	16	40	[	[	-LRB-
cord-000257-ampip7od	16	41	4	4	CD
cord-000257-ampip7od	16	42	]	]	-RRB-
cord-000257-ampip7od	16	43	[	[	-LRB-
cord-000257-ampip7od	16	44	5	5	CD
cord-000257-ampip7od	16	45	]	]	-RRB-
cord-000257-ampip7od	16	46	[	[	-LRB-
cord-000257-ampip7od	16	47	6	6	CD
cord-000257-ampip7od	16	48	]	]	-RRB-
cord-000257-ampip7od	16	49	.	.	.
cord-000257-ampip7od	17	1	In	in	IN
cord-000257-ampip7od	17	2	the	the	DT
cord-000257-ampip7od	17	3	meantime	meantime	NN
cord-000257-ampip7od	17	4	,	,	,
cord-000257-ampip7od	17	5	the	the	DT
cord-000257-ampip7od	17	6	genome	genome	NN
cord-000257-ampip7od	17	7	projects	project	NNS
cord-000257-ampip7od	17	8	of	of	IN
cord-000257-ampip7od	17	9	the	the	DT
cord-000257-ampip7od	17	10	last	last	JJ
cord-000257-ampip7od	17	11	decade	decade	NN
cord-000257-ampip7od	17	12	have	have	VBP
cord-000257-ampip7od	17	13	uncovered	uncover	VBN
cord-000257-ampip7od	17	14	an	an	DT
cord-000257-ampip7od	17	15	overwhelming	overwhelming	JJ
cord-000257-ampip7od	17	16	amount	amount	NN
cord-000257-ampip7od	17	17	of	of	IN
cord-000257-ampip7od	17	18	sequence	sequence	NN
cord-000257-ampip7od	17	19	data	datum	NNS
cord-000257-ampip7od	17	20	and	and	CC
cord-000257-ampip7od	17	21	researchers	researcher	NNS
cord-000257-ampip7od	17	22	are	be	VBP
cord-000257-ampip7od	17	23	now	now	RB
cord-000257-ampip7od	17	24	starting	start	VBG
cord-000257-ampip7od	17	25	to	to	TO
cord-000257-ampip7od	17	26	address	address	VB
cord-000257-ampip7od	17	27	a	a	DT
cord-000257-ampip7od	17	28	series	series	NN
cord-000257-ampip7od	17	29	of	of	IN
cord-000257-ampip7od	17	30	fundamental	fundamental	JJ
cord-000257-ampip7od	17	31	questions	question	NNS
cord-000257-ampip7od	17	32	that	that	WDT
cord-000257-ampip7od	17	33	should	should	MD
cord-000257-ampip7od	17	34	shed	shed	VB
cord-000257-ampip7od	17	35	light	light	NN
cord-000257-ampip7od	17	36	onto	onto	IN
cord-000257-ampip7od	17	37	protein	protein	NN
cord-000257-ampip7od	17	38	evolution	evolution	NN
cord-000257-ampip7od	17	39	processes	process	NNS
cord-000257-ampip7od	17	40	[	[	-LRB-
cord-000257-ampip7od	17	41	7	7	CD
cord-000257-ampip7od	17	42	]	]	-RRB-
cord-000257-ampip7od	17	43	[	[	-LRB-
cord-000257-ampip7od	17	44	8	8	CD
cord-000257-ampip7od	17	45	]	]	-RRB-
cord-000257-ampip7od	17	46	[	[	-LRB-
cord-000257-ampip7od	17	47	9	9	CD
cord-000257-ampip7od	17	48	]	]	-RRB-
cord-000257-ampip7od	17	49	[	[	-LRB-
cord-000257-ampip7od	17	50	10	10	CD
cord-000257-ampip7od	17	51	]	]	-RRB-
cord-000257-ampip7od	17	52	.	.	.
cord-000257-ampip7od	18	1	For	for	IN
cord-000257-ampip7od	18	2	instance	instance	NN
cord-000257-ampip7od	18	3	,	,	,
cord-000257-ampip7od	18	4	how	how	WRB
cord-000257-ampip7od	18	5	many	many	JJ
cord-000257-ampip7od	18	6	gene	gene	NN
cord-000257-ampip7od	18	7	encoding	encoding	NN
cord-000257-ampip7od	18	8	sequences	sequence	NNS
cord-000257-ampip7od	18	9	are	be	VBP
cord-000257-ampip7od	18	10	present	present	JJ
cord-000257-ampip7od	18	11	in	in	IN
cord-000257-ampip7od	18	12	one	one	CD
cord-000257-ampip7od	18	13	genome	genome	NN
cord-000257-ampip7od	18	14	?	?	.
cord-000257-ampip7od	19	1	How	how	WRB
cord-000257-ampip7od	19	2	many	many	JJ
cord-000257-ampip7od	19	3	sequences	sequence	NNS
cord-000257-ampip7od	19	4	are	be	VBP
cord-000257-ampip7od	19	5	repetitive	repetitive	JJ
cord-000257-ampip7od	19	6	and	and	CC
cord-000257-ampip7od	19	7	are	be	VBP
cord-000257-ampip7od	19	8	these	these	DT
cord-000257-ampip7od	19	9	sequences	sequence	NNS
cord-000257-ampip7od	19	10	similar	similar	JJ
cord-000257-ampip7od	19	11	in	in	IN
cord-000257-ampip7od	19	12	the	the	DT
cord-000257-ampip7od	19	13	various	various	JJ
cord-000257-ampip7od	19	14	organisms	organism	NNS
cord-000257-ampip7od	19	15	on	on	IN
cord-000257-ampip7od	19	16	Earth	Earth	NNP
cord-000257-ampip7od	19	17	?	?	.
cord-000257-ampip7od	20	1	Which	which	WDT
cord-000257-ampip7od	20	2	genes	gene	NNS
cord-000257-ampip7od	20	3	were	be	VBD
cord-000257-ampip7od	20	4	involved	involve	VBN
cord-000257-ampip7od	20	5	in	in	IN
cord-000257-ampip7od	20	6	the	the	DT
cord-000257-ampip7od	20	7	large	large	JJ
cord-000257-ampip7od	20	8	scale	scale	NN
cord-000257-ampip7od	20	9	genome	genome	NN
cord-000257-ampip7od	20	10	duplications	duplication	NNS
cord-000257-ampip7od	20	11	that	that	WDT
cord-000257-ampip7od	20	12	we	-PRON-	PRP
cord-000257-ampip7od	20	13	see	see	VBP
cord-000257-ampip7od	20	14	in	in	IN
cord-000257-ampip7od	20	15	animals	animal	NNS
cord-000257-ampip7od	20	16	?	?	.
cord-000257-ampip7od	21	1	A	a	DT
cord-000257-ampip7od	21	2	comparison	comparison	NN
cord-000257-ampip7od	21	3	of	of	IN
cord-000257-ampip7od	21	4	sequences	sequence	NNS
cord-000257-ampip7od	21	5	for	for	IN
cord-000257-ampip7od	21	6	evolutionary	evolutionary	JJ
cord-000257-ampip7od	21	7	insight	insight	NN
cord-000257-ampip7od	21	8	is	be	VBZ
cord-000257-ampip7od	21	9	best	well	RBS
cord-000257-ampip7od	21	10	achieved	achieve	VBN
cord-000257-ampip7od	21	11	by	by	IN
cord-000257-ampip7od	21	12	looking	look	VBG
cord-000257-ampip7od	21	13	at	at	IN
cord-000257-ampip7od	21	14	the	the	DT
cord-000257-ampip7od	21	15	structural	structural	JJ
cord-000257-ampip7od	21	16	and	and	CC
cord-000257-ampip7od	21	17	functional	functional	JJ
cord-000257-ampip7od	21	18	(	(	-LRB-
cord-000257-ampip7od	21	19	sub)units	sub)unit	NNS
cord-000257-ampip7od	21	20	of	of	IN
cord-000257-ampip7od	21	21	proteins	protein	NNS
cord-000257-ampip7od	21	22	,	,	,
cord-000257-ampip7od	21	23	the	the	DT
cord-000257-ampip7od	21	24	protein	protein	NN
cord-000257-ampip7od	21	25	domains	domain	NNS
cord-000257-ampip7od	21	26	.	.	.
cord-000257-ampip7od	22	1	By	by	IN
cord-000257-ampip7od	22	2	convention	convention	NN
cord-000257-ampip7od	22	3	,	,	,
cord-000257-ampip7od	22	4	domains	domain	NNS
cord-000257-ampip7od	22	5	are	be	VBP
cord-000257-ampip7od	22	6	defined	define	VBN
cord-000257-ampip7od	22	7	as	as	IN
cord-000257-ampip7od	22	8	conserved	conserve	VBN
cord-000257-ampip7od	22	9	,	,	,
cord-000257-ampip7od	22	10	functionally	functionally	RB
cord-000257-ampip7od	22	11	independent	independent	JJ
cord-000257-ampip7od	22	12	protein	protein	NN
cord-000257-ampip7od	22	13	sequences	sequence	NNS
cord-000257-ampip7od	22	14	,	,	,
cord-000257-ampip7od	22	15	which	which	WDT
cord-000257-ampip7od	22	16	bind	bind	VBP
cord-000257-ampip7od	22	17	or	or	CC
cord-000257-ampip7od	22	18	process	process	NN
cord-000257-ampip7od	22	19	ligands	ligand	NNS
cord-000257-ampip7od	22	20	using	use	VBG
cord-000257-ampip7od	22	21	a	a	DT
cord-000257-ampip7od	22	22	core	core	NN
cord-000257-ampip7od	22	23	structural	structural	JJ
cord-000257-ampip7od	22	24	motif	motif	NN
cord-000257-ampip7od	22	25	[	[	-LRB-
cord-000257-ampip7od	22	26	11	11	CD
cord-000257-ampip7od	22	27	]	]	-RRB-
cord-000257-ampip7od	22	28	[	[	-LRB-
cord-000257-ampip7od	22	29	12	12	CD
cord-000257-ampip7od	22	30	]	]	-RRB-
cord-000257-ampip7od	22	31	[	[	-LRB-
cord-000257-ampip7od	22	32	13	13	CD
cord-000257-ampip7od	22	33	]	]	-RRB-
cord-000257-ampip7od	22	34	.	.	.
cord-000257-ampip7od	23	1	Examples	example	NNS
cord-000257-ampip7od	23	2	of	of	IN
cord-000257-ampip7od	23	3	domain	domain	NN
cord-000257-ampip7od	23	4	modes	mode	NNS
cord-000257-ampip7od	23	5	of	of	IN
cord-000257-ampip7od	23	6	actions	action	NNS
cord-000257-ampip7od	23	7	in	in	IN
cord-000257-ampip7od	23	8	signaling	signal	VBG
cord-000257-ampip7od	23	9	cascades	cascade	NNS
cord-000257-ampip7od	23	10	for	for	IN
cord-000257-ampip7od	23	11	instance	instance	NN
cord-000257-ampip7od	23	12	,	,	,
cord-000257-ampip7od	23	13	are	be	VBP
cord-000257-ampip7od	23	14	to	to	TO
cord-000257-ampip7od	23	15	connect	connect	VB
cord-000257-ampip7od	23	16	different	different	JJ
cord-000257-ampip7od	23	17	components	component	NNS
cord-000257-ampip7od	23	18	into	into	IN
cord-000257-ampip7od	23	19	a	a	DT
cord-000257-ampip7od	23	20	larger	large	JJR
cord-000257-ampip7od	23	21	complex	complex	NN
cord-000257-ampip7od	23	22	or	or	CC
cord-000257-ampip7od	23	23	to	to	TO
cord-000257-ampip7od	23	24	bind	bind	VB
cord-000257-ampip7od	23	25	signaling	signal	VBG
cord-000257-ampip7od	23	26	-	-	HYPH
cord-000257-ampip7od	23	27	molecules	molecule	NNS
cord-000257-ampip7od	23	28	[	[	-LRB-
cord-000257-ampip7od	23	29	14	14	CD
cord-000257-ampip7od	23	30	,	,	,
cord-000257-ampip7od	23	31	15	15	CD
cord-000257-ampip7od	23	32	]	]	-RRB-
cord-000257-ampip7od	23	33	.	.	.
cord-000257-ampip7od	24	1	Protein	protein	NN
cord-000257-ampip7od	24	2	domains	domain	NNS
cord-000257-ampip7od	24	3	can	can	MD
cord-000257-ampip7od	24	4	usually	usually	RB
cord-000257-ampip7od	24	5	fold	fold	VB
cord-000257-ampip7od	24	6	independently	independently	RB
cord-000257-ampip7od	24	7	,	,	,
cord-000257-ampip7od	24	8	likely	likely	RB
cord-000257-ampip7od	24	9	due	due	IN
cord-000257-ampip7od	24	10	to	to	IN
cord-000257-ampip7od	24	11	their	-PRON-	PRP$
cord-000257-ampip7od	24	12	relatively	relatively	RB
cord-000257-ampip7od	24	13	limited	limited	JJ
cord-000257-ampip7od	24	14	size	size	NN
cord-000257-ampip7od	24	15	,	,	,
cord-000257-ampip7od	24	16	and	and	CC
cord-000257-ampip7od	24	17	are	be	VBP
cord-000257-ampip7od	24	18	well	well	RB
cord-000257-ampip7od	24	19	known	known	JJ
cord-000257-ampip7od	24	20	to	to	TO
cord-000257-ampip7od	24	21	behave	behave	VB
cord-000257-ampip7od	24	22	as	as	IN
cord-000257-ampip7od	24	23	independent	independent	JJ
cord-000257-ampip7od	24	24	genetic	genetic	JJ
cord-000257-ampip7od	24	25	elements	element	NNS
cord-000257-ampip7od	24	26	within	within	IN
cord-000257-ampip7od	24	27	genomes	genome	NNS
cord-000257-ampip7od	24	28	[	[	-LRB-
cord-000257-ampip7od	24	29	16	16	CD
cord-000257-ampip7od	24	30	,	,	,
cord-000257-ampip7od	24	31	17	17	CD
cord-000257-ampip7od	24	32	]	]	-RRB-
cord-000257-ampip7od	24	33	.	.	.
cord-000257-ampip7od	25	1	The	the	DT
cord-000257-ampip7od	25	2	sum	sum	NN
cord-000257-ampip7od	25	3	of	of	IN
cord-000257-ampip7od	25	4	these	these	DT
cord-000257-ampip7od	25	5	features	feature	NNS
cord-000257-ampip7od	25	6	makes	make	VBZ
cord-000257-ampip7od	25	7	protein	protein	NN
cord-000257-ampip7od	25	8	domains	domain	NNS
cord-000257-ampip7od	25	9	readily	readily	RB
cord-000257-ampip7od	25	10	identifiable	identifiable	JJ
cord-000257-ampip7od	25	11	from	from	IN
cord-000257-ampip7od	25	12	raw	raw	JJ
cord-000257-ampip7od	25	13	nucleotide	nucleotide	NN
cord-000257-ampip7od	25	14	and	and	CC
cord-000257-ampip7od	25	15	amino	amino	NN
cord-000257-ampip7od	25	16	acid	acid	NN
cord-000257-ampip7od	25	17	sequences	sequence	NNS
cord-000257-ampip7od	25	18	and	and	CC
cord-000257-ampip7od	25	19	many	many	JJ
cord-000257-ampip7od	25	20	protein	protein	NN
cord-000257-ampip7od	25	21	family	family	NN
cord-000257-ampip7od	25	22	resources	resource	NNS
cord-000257-ampip7od	25	23	(	(	-LRB-
cord-000257-ampip7od	25	24	e.g.	e.g.	RB
cord-000257-ampip7od	25	25	,	,	,
cord-000257-ampip7od	25	26	Superfamily	Superfamily	NNP
cord-000257-ampip7od	25	27	and	and	CC
cord-000257-ampip7od	25	28	SMART	SMART	NNP
cord-000257-ampip7od	25	29	[	[	-LRB-
cord-000257-ampip7od	25	30	see	see	UH
cord-000257-ampip7od	25	31	Table	table	NN
cord-000257-ampip7od	25	32	1	1	CD
cord-000257-ampip7od	25	33	]	]	-RRB-
cord-000257-ampip7od	25	34	)	)	-RRB-
cord-000257-ampip7od	25	35	indeed	indeed	RB
cord-000257-ampip7od	25	36	fully	fully	RB
cord-000257-ampip7od	25	37	rely	rely	VB
cord-000257-ampip7od	25	38	on	on	IN
cord-000257-ampip7od	25	39	such	such	JJ
cord-000257-ampip7od	25	40	sequence	sequence	NN
cord-000257-ampip7od	25	41	similarity	similarity	NN
cord-000257-ampip7od	25	42	and	and	CC
cord-000257-ampip7od	25	43	motif	motif	NN
cord-000257-ampip7od	25	44	identifications	identification	NNS
cord-000257-ampip7od	25	45	[	[	-LRB-
cord-000257-ampip7od	25	46	18	18	CD
cord-000257-ampip7od	25	47	,	,	,
cord-000257-ampip7od	25	48	19	19	CD
cord-000257-ampip7od	25	49	]	]	-RRB-
cord-000257-ampip7od	25	50	.	.	.
cord-000257-ampip7od	26	1	The	the	DT
cord-000257-ampip7od	26	2	algorithms	algorithm	NNS
cord-000257-ampip7od	26	3	that	that	WDT
cord-000257-ampip7od	26	4	are	be	VBP
cord-000257-ampip7od	26	5	used	use	VBN
cord-000257-ampip7od	26	6	for	for	IN
cord-000257-ampip7od	26	7	domain	domain	NN
cord-000257-ampip7od	26	8	identification	identification	NN
cord-000257-ampip7od	26	9	are	be	VBP
cord-000257-ampip7od	26	10	built	build	VBN
cord-000257-ampip7od	26	11	around	around	IN
cord-000257-ampip7od	26	12	a	a	DT
cord-000257-ampip7od	26	13	set	set	NN
cord-000257-ampip7od	26	14	of	of	IN
cord-000257-ampip7od	26	15	simple	simple	JJ
cord-000257-ampip7od	26	16	assumptions	assumption	NNS
cord-000257-ampip7od	26	17	that	that	WDT
cord-000257-ampip7od	26	18	describe	describe	VBP
cord-000257-ampip7od	26	19	the	the	DT
cord-000257-ampip7od	26	20	process	process	NN
cord-000257-ampip7od	26	21	of	of	IN
cord-000257-ampip7od	26	22	evolution	evolution	NN
cord-000257-ampip7od	26	23	.	.	.
cord-000257-ampip7od	27	1	In	in	IN
cord-000257-ampip7od	27	2	general	general	JJ
cord-000257-ampip7od	27	3	,	,	,
cord-000257-ampip7od	27	4	evolution	evolution	NN
cord-000257-ampip7od	27	5	is	be	VBZ
cord-000257-ampip7od	27	6	believed	believe	VBN
cord-000257-ampip7od	27	7	to	to	TO
cord-000257-ampip7od	27	8	form	form	VB
cord-000257-ampip7od	27	9	and	and	CC
cord-000257-ampip7od	27	10	mold	mold	NN
cord-000257-ampip7od	27	11	genomes	genome	NNS
cord-000257-ampip7od	27	12	largely	largely	RB
cord-000257-ampip7od	27	13	via	via	IN
cord-000257-ampip7od	27	14	three	three	CD
cord-000257-ampip7od	27	15	mechanisms	mechanism	NNS
cord-000257-ampip7od	27	16	,	,	,
cord-000257-ampip7od	27	17	namely	namely	RB
cord-000257-ampip7od	27	18	i	i	NN
cord-000257-ampip7od	27	19	)	)	-RRB-
cord-000257-ampip7od	27	20	chemical	chemical	NN
cord-000257-ampip7od	27	21	changes	change	NNS
cord-000257-ampip7od	27	22	through	through	IN
cord-000257-ampip7od	27	23	the	the	DT
cord-000257-ampip7od	27	24	incorporation	incorporation	NN
cord-000257-ampip7od	27	25	of	of	IN
cord-000257-ampip7od	27	26	base	base	NN
cord-000257-ampip7od	27	27	analogs	analog	NNS
cord-000257-ampip7od	27	28	,	,	,
cord-000257-ampip7od	27	29	the	the	DT
cord-000257-ampip7od	27	30	effects	effect	NNS
cord-000257-ampip7od	27	31	of	of	IN
cord-000257-ampip7od	27	32	radiation	radiation	NN
cord-000257-ampip7od	27	33	or	or	CC
cord-000257-ampip7od	27	34	random	random	JJ
cord-000257-ampip7od	27	35	enzymatic	enzymatic	JJ
cord-000257-ampip7od	27	36	errors	error	NNS
cord-000257-ampip7od	27	37	by	by	IN
cord-000257-ampip7od	27	38	polymerases	polymerase	NNS
cord-000257-ampip7od	27	39	,	,	,
cord-000257-ampip7od	27	40	ii	ii	LS
cord-000257-ampip7od	27	41	)	)	-RRB-
cord-000257-ampip7od	27	42	cellular	cellular	JJ
cord-000257-ampip7od	27	43	repair	repair	NN
cord-000257-ampip7od	27	44	processes	process	NNS
cord-000257-ampip7od	27	45	that	that	WDT
cord-000257-ampip7od	27	46	counter	counter	VBP
cord-000257-ampip7od	27	47	mutations	mutation	NNS
cord-000257-ampip7od	27	48	,	,	,
cord-000257-ampip7od	27	49	and	and	CC
cord-000257-ampip7od	27	50	iii	iii	LS
cord-000257-ampip7od	27	51	)	)	-RRB-
cord-000257-ampip7od	27	52	selection	selection	NN
cord-000257-ampip7od	27	53	pressures	pressure	NNS
cord-000257-ampip7od	27	54	that	that	WDT
cord-000257-ampip7od	27	55	manifest	manifest	VBP
cord-000257-ampip7od	27	56	themselves	-PRON-	PRP
cord-000257-ampip7od	27	57	as	as	IN
cord-000257-ampip7od	27	58	the	the	DT
cord-000257-ampip7od	27	59	positive	positive	JJ
cord-000257-ampip7od	27	60	or	or	CC
cord-000257-ampip7od	27	61	negative	negative	JJ
cord-000257-ampip7od	27	62	influence	influence	NN
cord-000257-ampip7od	27	63	that	that	WDT
cord-000257-ampip7od	27	64	determines	determine	VBZ
cord-000257-ampip7od	27	65	whether	whether	IN
cord-000257-ampip7od	27	66	the	the	DT
cord-000257-ampip7od	27	67	mutation	mutation	NN
cord-000257-ampip7od	27	68	will	will	MD
cord-000257-ampip7od	27	69	be	be	VB
cord-000257-ampip7od	27	70	present	present	JJ
cord-000257-ampip7od	27	71	in	in	IN
cord-000257-ampip7od	27	72	subsequent	subsequent	JJ
cord-000257-ampip7od	27	73	generations	generation	NNS
cord-000257-ampip7od	27	74	[	[	-LRB-
cord-000257-ampip7od	27	75	20	20	CD
cord-000257-ampip7od	27	76	,	,	,
cord-000257-ampip7od	27	77	21	21	CD
cord-000257-ampip7od	27	78	]	]	-RRB-
cord-000257-ampip7od	27	79	.	.	.
cord-000257-ampip7od	28	1	By	by	IN
cord-000257-ampip7od	28	2	definition	definition	NN
cord-000257-ampip7od	28	3	,	,	,
cord-000257-ampip7od	28	4	each	each	DT
cord-000257-ampip7od	28	5	of	of	IN
cord-000257-ampip7od	28	6	these	these	DT
cord-000257-ampip7od	28	7	phenomena	phenomena	JJ
cord-000257-ampip7od	28	8	styles	style	NNS
cord-000257-ampip7od	28	9	,	,	,
cord-000257-ampip7od	28	10	reproductive	reproductive	JJ
cord-000257-ampip7od	28	11	strategies	strategy	NNS
cord-000257-ampip7od	28	12	,	,	,
cord-000257-ampip7od	28	13	or	or	CC
cord-000257-ampip7od	28	14	the	the	DT
cord-000257-ampip7od	28	15	lack	lack	NN
cord-000257-ampip7od	28	16	of	of	IN
cord-000257-ampip7od	28	17	apparent	apparent	JJ
cord-000257-ampip7od	28	18	polymerase	polymerase	NN
cord-000257-ampip7od	28	19	-	-	HYPH
cord-000257-ampip7od	28	20	dependent	dependent	JJ
cord-000257-ampip7od	28	21	proofreading	proofreading	NN
cord-000257-ampip7od	28	22	such	such	JJ
cord-000257-ampip7od	28	23	as	as	IN
cord-000257-ampip7od	28	24	in	in	IN
cord-000257-ampip7od	28	25	positivestranded	positivestranded	JJ
cord-000257-ampip7od	28	26	RNA	RNA	NNP
cord-000257-ampip7od	28	27	viruses	virus	NNS
cord-000257-ampip7od	28	28	[	[	-LRB-
cord-000257-ampip7od	28	29	22	22	CD
cord-000257-ampip7od	28	30	]	]	-RRB-
cord-000257-ampip7od	28	31	[	[	-LRB-
cord-000257-ampip7od	28	32	23	23	CD
cord-000257-ampip7od	28	33	]	]	-RRB-
cord-000257-ampip7od	28	34	[	[	-LRB-
cord-000257-ampip7od	28	35	24	24	CD
cord-000257-ampip7od	28	36	]	]	-RRB-
cord-000257-ampip7od	28	37	[	[	-LRB-
cord-000257-ampip7od	28	38	25	25	CD
cord-000257-ampip7od	28	39	]	]	-RRB-
cord-000257-ampip7od	28	40	.	.	.
cord-000257-ampip7od	29	1	Consequently	consequently	RB
cord-000257-ampip7od	29	2	,	,	,
cord-000257-ampip7od	29	3	substitution	substitution	NN
cord-000257-ampip7od	29	4	rates	rate	NNS
cord-000257-ampip7od	29	5	need	need	VBP
cord-000257-ampip7od	29	6	therefore	therefore	RB
cord-000257-ampip7od	29	7	be	be	VB
cord-000257-ampip7od	29	8	calculated	calculate	VBN
cord-000257-ampip7od	29	9	to	to	TO
cord-000257-ampip7od	29	10	correctly	correctly	RB
cord-000257-ampip7od	29	11	compare	compare	VB
cord-000257-ampip7od	29	12	two	two	CD
cord-000257-ampip7od	29	13	or	or	CC
cord-000257-ampip7od	29	14	more	more	JJR
cord-000257-ampip7od	29	15	sequences	sequence	NNS
cord-000257-ampip7od	29	16	and	and	CC
cord-000257-ampip7od	29	17	hunt	hunt	VB
cord-000257-ampip7od	29	18	uncharted	uncharted	JJ
cord-000257-ampip7od	29	19	genomes	genome	NNS
cord-000257-ampip7od	29	20	for	for	IN
cord-000257-ampip7od	29	21	comparable	comparable	JJ
cord-000257-ampip7od	29	22	domains	domain	NNS
cord-000257-ampip7od	29	23	.	.	.
cord-000257-ampip7od	30	1	Particularly	particularly	RB
cord-000257-ampip7od	30	2	this	this	DT
cord-000257-ampip7od	30	3	last	last	JJ
cord-000257-ampip7od	30	4	strategy	strategy	NN
cord-000257-ampip7od	30	5	,	,	,
cord-000257-ampip7od	30	6	using	use	VBG
cord-000257-ampip7od	30	7	general	general	JJ
cord-000257-ampip7od	30	8	rate	rate	NN
cord-000257-ampip7od	30	9	matrices	matrix	NNS
cord-000257-ampip7od	30	10	like	like	IN
cord-000257-ampip7od	30	11	BLOSOM	BLOSOM	NNP
cord-000257-ampip7od	30	12	and	and	CC
cord-000257-ampip7od	30	13	PAM	PAM	NNP
cord-000257-ampip7od	30	14	,	,	,
cord-000257-ampip7od	30	15	is	be	VBZ
cord-000257-ampip7od	30	16	an	an	DT
cord-000257-ampip7od	30	17	elegant	elegant	JJ
cord-000257-ampip7od	30	18	example	example	NN
cord-000257-ampip7od	30	19	of	of	IN
cord-000257-ampip7od	30	20	how	how	WRB
cord-000257-ampip7od	30	21	new	new	JJ
cord-000257-ampip7od	30	22	protein	protein	NN
cord-000257-ampip7od	30	23	functions	function	NNS
cord-000257-ampip7od	30	24	can	can	MD
cord-000257-ampip7od	30	25	be	be	VB
cord-000257-ampip7od	30	26	discovered	discover	VBN
cord-000257-ampip7od	30	27	[	[	-LRB-
cord-000257-ampip7od	30	28	26	26	CD
cord-000257-ampip7od	30	29	]	]	-RRB-
cord-000257-ampip7od	30	30	[	[	-LRB-
cord-000257-ampip7od	30	31	27	27	CD
cord-000257-ampip7od	30	32	]	]	-RRB-
cord-000257-ampip7od	30	33	[	[	-LRB-
cord-000257-ampip7od	30	34	28	28	CD
cord-000257-ampip7od	30	35	]	]	-RRB-
cord-000257-ampip7od	30	36	[	[	-LRB-
cord-000257-ampip7od	30	37	29	29	CD
cord-000257-ampip7od	30	38	]	]	-RRB-
cord-000257-ampip7od	30	39	[	[	-LRB-
cord-000257-ampip7od	30	40	30	30	CD
cord-000257-ampip7od	30	41	]	]	-RRB-
cord-000257-ampip7od	30	42	.	.	.
cord-000257-ampip7od	31	1	Fast	fast	JJ
cord-000257-ampip7od	31	2	algorithms	algorithm	NNS
cord-000257-ampip7od	31	3	for	for	IN
cord-000257-ampip7od	31	4	pair	pair	NN
cord-000257-ampip7od	31	5	-	-	HYPH
cord-000257-ampip7od	31	6	wise	wise	JJ
cord-000257-ampip7od	31	7	alignments	alignment	NNS
cord-000257-ampip7od	31	8	can	can	MD
cord-000257-ampip7od	31	9	be	be	VB
cord-000257-ampip7od	31	10	found	find	VBN
cord-000257-ampip7od	31	11	in	in	IN
cord-000257-ampip7od	31	12	the	the	DT
cord-000257-ampip7od	31	13	Basic	Basic	NNP
cord-000257-ampip7od	31	14	Local	Local	NNP
cord-000257-ampip7od	31	15	Alignment	Alignment	NNP
cord-000257-ampip7od	31	16	Search	Search	NNP
cord-000257-ampip7od	31	17	Tool	tool	NN
cord-000257-ampip7od	31	18	(	(	-LRB-
cord-000257-ampip7od	31	19	BLAST	blast	NN
cord-000257-ampip7od	31	20	)	)	-RRB-
cord-000257-ampip7od	31	21	,	,	,
cord-000257-ampip7od	31	22	whereas	whereas	IN
cord-000257-ampip7od	31	23	multiple	multiple	JJ
cord-000257-ampip7od	31	24	sequence	sequence	NN
cord-000257-ampip7od	31	25	alignments	alignment	NNS
cord-000257-ampip7od	31	26	(	(	-LRB-
cord-000257-ampip7od	31	27	MSAs	msa	NNS
cord-000257-ampip7od	31	28	,	,	,
cord-000257-ampip7od	31	29	Fig	Fig	NNP
cord-000257-ampip7od	31	30	.	.	.
cord-000257-ampip7od	31	31	1A	1a	NN
cord-000257-ampip7od	31	32	)	)	-RRB-
cord-000257-ampip7od	31	33	in	in	IN
cord-000257-ampip7od	31	34	which	which	WDT
cord-000257-ampip7od	31	35	multiple	multiple	JJ
cord-000257-ampip7od	31	36	sequences	sequence	NNS
cord-000257-ampip7od	31	37	are	be	VBP
cord-000257-ampip7od	31	38	compared	compare	VBN
cord-000257-ampip7od	31	39	simultaneously	simultaneously	RB
cord-000257-ampip7od	31	40	are	be	VBP
cord-000257-ampip7od	31	41	commonly	commonly	RB
cord-000257-ampip7od	31	42	created	create	VBN
cord-000257-ampip7od	31	43	with	with	IN
cord-000257-ampip7od	31	44	for	for	IN
cord-000257-ampip7od	31	45	example	example	NN
cord-000257-ampip7od	31	46	ClustalX	ClustalX	NNS
cord-000257-ampip7od	31	47	and	and	CC
cord-000257-ampip7od	31	48	MUSCLE	MUSCLE	NNP
cord-000257-ampip7od	31	49	(	(	-LRB-
cord-000257-ampip7od	31	50	see	see	VB
cord-000257-ampip7od	31	51	Table	Table	NNP
cord-000257-ampip7od	31	52	 	 	_SP
cord-000257-ampip7od	31	53	1	1	CD
cord-000257-ampip7od	31	54	)	)	-RRB-
cord-000257-ampip7od	32	1	[	[	-LRB-
cord-000257-ampip7od	32	2	31	31	CD
cord-000257-ampip7od	32	3	]	]	-RRB-
cord-000257-ampip7od	32	4	[	[	-LRB-
cord-000257-ampip7od	32	5	32	32	CD
cord-000257-ampip7od	32	6	]	]	-RRB-
cord-000257-ampip7od	33	1	[	[	-LRB-
cord-000257-ampip7od	33	2	33	33	CD
cord-000257-ampip7od	33	3	]	]	-RRB-
cord-000257-ampip7od	33	4	[	[	-LRB-
cord-000257-ampip7od	33	5	34	34	CD
cord-000257-ampip7od	33	6	]	]	-RRB-
cord-000257-ampip7od	33	7	.	.	.
cord-000257-ampip7od	34	1	Close	close	JJ
cord-000257-ampip7od	34	2	relatives	relative	NNS
cord-000257-ampip7od	34	3	,	,	,
cord-000257-ampip7od	34	4	sharing	share	VBG
cord-000257-ampip7od	34	5	an	an	DT
cord-000257-ampip7od	34	6	overall	overall	JJ
cord-000257-ampip7od	34	7	sequence	sequence	NN
cord-000257-ampip7od	34	8	identity	identity	NN
cord-000257-ampip7od	34	9	above	above	IN
cord-000257-ampip7od	34	10	for	for	IN
cord-000257-ampip7od	34	11	example	example	NN
cord-000257-ampip7od	34	12	50	50	CD
cord-000257-ampip7od	34	13	%	%	NN
cord-000257-ampip7od	34	14	and	and	CC
cord-000257-ampip7od	34	15	a	a	DT
cord-000257-ampip7od	34	16	set	set	NN
cord-000257-ampip7od	34	17	of	of	IN
cord-000257-ampip7od	34	18	functional	functional	JJ
cord-000257-ampip7od	34	19	properties	property	NNS
cord-000257-ampip7od	34	20	,	,	,
cord-000257-ampip7od	34	21	can	can	MD
cord-000257-ampip7od	34	22	also	also	RB
cord-000257-ampip7od	34	23	be	be	VB
cord-000257-ampip7od	34	24	grouped	group	VBN
cord-000257-ampip7od	34	25	into	into	IN
cord-000257-ampip7od	34	26	families	family	NNS
cord-000257-ampip7od	34	27	and	and	CC
cord-000257-ampip7od	34	28	subfamilies	subfamily	NNS
cord-000257-ampip7od	34	29	.	.	.
cord-000257-ampip7od	35	1	In	in	IN
cord-000257-ampip7od	35	2	turn	turn	NN
cord-000257-ampip7od	35	3	,	,	,
cord-000257-ampip7od	35	4	these	these	DT
cord-000257-ampip7od	35	5	families	family	NNS
cord-000257-ampip7od	35	6	share	share	VBP
cord-000257-ampip7od	35	7	also	also	RB
cord-000257-ampip7od	35	8	evolutionary	evolutionary	JJ
cord-000257-ampip7od	35	9	relationships	relationship	NNS
cord-000257-ampip7od	35	10	with	with	IN
cord-000257-ampip7od	35	11	other	other	JJ
cord-000257-ampip7od	35	12	domains	domain	NNS
cord-000257-ampip7od	35	13	and	and	CC
cord-000257-ampip7od	35	14	form	form	VB
cord-000257-ampip7od	35	15	together	together	RB
cord-000257-ampip7od	35	16	so	so	RB
cord-000257-ampip7od	35	17	-	-	HYPH
cord-000257-ampip7od	35	18	called	call	VBN
cord-000257-ampip7od	35	19	domain	domain	NN
cord-000257-ampip7od	35	20	superfamilies	superfamily	NNS
cord-000257-ampip7od	35	21	[	[	-LRB-
cord-000257-ampip7od	35	22	18	18	CD
cord-000257-ampip7od	35	23	,	,	,
cord-000257-ampip7od	35	24	35	35	CD
cord-000257-ampip7od	35	25	]	]	-RRB-
cord-000257-ampip7od	35	26	.	.	.
cord-000257-ampip7od	36	1	Evolutionary	evolutionary	JJ
cord-000257-ampip7od	36	2	distances	distance	NNS
cord-000257-ampip7od	36	3	between	between	IN
cord-000257-ampip7od	36	4	related	related	JJ
cord-000257-ampip7od	36	5	domain	domain	NN
cord-000257-ampip7od	36	6	sequences	sequence	NNS
cord-000257-ampip7od	36	7	can	can	MD
cord-000257-ampip7od	36	8	easily	easily	RB
cord-000257-ampip7od	36	9	be	be	VB
cord-000257-ampip7od	36	10	estimated	estimate	VBN
cord-000257-ampip7od	36	11	from	from	IN
cord-000257-ampip7od	36	12	sequence	sequence	NN
cord-000257-ampip7od	36	13	alignments	alignment	NNS
cord-000257-ampip7od	36	14	,	,	,
cord-000257-ampip7od	36	15	provided	provide	VBN
cord-000257-ampip7od	36	16	that	that	IN
cord-000257-ampip7od	36	17	the	the	DT
cord-000257-ampip7od	36	18	correct	correct	JJ
cord-000257-ampip7od	36	19	rate	rate	NN
cord-000257-ampip7od	36	20	assumptions	assumption	NNS
cord-000257-ampip7od	36	21	are	be	VBP
cord-000257-ampip7od	36	22	made	make	VBN
cord-000257-ampip7od	36	23	.	.	.
cord-000257-ampip7od	37	1	Subsequently	subsequently	RB
cord-000257-ampip7od	37	2	,	,	,
cord-000257-ampip7od	37	3	these	these	DT
cord-000257-ampip7od	37	4	can	can	MD
cord-000257-ampip7od	37	5	be	be	VB
cord-000257-ampip7od	37	6	used	use	VBN
cord-000257-ampip7od	37	7	to	to	TO
cord-000257-ampip7od	37	8	compute	compute	VB
cord-000257-ampip7od	37	9	the	the	DT
cord-000257-ampip7od	37	10	phylogenies	phylogeny	NNS
cord-000257-ampip7od	37	11	of	of	IN
cord-000257-ampip7od	37	12	the	the	DT
cord-000257-ampip7od	37	13	domain	domain	NN
cord-000257-ampip7od	37	14	that	that	WDT
cord-000257-ampip7od	37	15	share	share	VBP
cord-000257-ampip7od	37	16	an	an	DT
cord-000257-ampip7od	37	17	evolutionary	evolutionary	JJ
cord-000257-ampip7od	37	18	history	history	NN
cord-000257-ampip7od	37	19	.	.	.
cord-000257-ampip7od	38	1	These	these	DT
cord-000257-ampip7od	38	2	,	,	,
cord-000257-ampip7od	38	3	often	often	RB
cord-000257-ampip7od	38	4	tree	tree	NN
cord-000257-ampip7od	38	5	-	-	HYPH
cord-000257-ampip7od	38	6	like	like	JJ
cord-000257-ampip7od	38	7	graphs	graph	NNS
cord-000257-ampip7od	38	8	(	(	-LRB-
cord-000257-ampip7od	38	9	Fig	fig	NN
cord-000257-ampip7od	38	10	.	.	.
cord-000257-ampip7od	38	11	1B	1b	LS
cord-000257-ampip7od	38	12	)	)	-RRB-
cord-000257-ampip7od	38	13	,	,	,
cord-000257-ampip7od	38	14	depend	depend	VBP
cord-000257-ampip7od	38	15	heavily	heavily	RB
cord-000257-ampip7od	38	16	on	on	IN
cord-000257-ampip7od	38	17	rate	rate	NN
cord-000257-ampip7od	38	18	variation	variation	NN
cord-000257-ampip7od	38	19	models	model	NNS
cord-000257-ampip7od	38	20	,	,	,
cord-000257-ampip7od	38	21	such	such	JJ
cord-000257-ampip7od	38	22	as	as	IN
cord-000257-ampip7od	38	23	molecular	molecular	JJ
cord-000257-ampip7od	38	24	clocks	clock	NNS
cord-000257-ampip7od	38	25	or	or	CC
cord-000257-ampip7od	38	26	relaxed	relaxed	JJ
cord-000257-ampip7od	38	27	molecular	molecular	JJ
cord-000257-ampip7od	38	28	clocks	clock	NNS
cord-000257-ampip7od	38	29	(	(	-LRB-
cord-000257-ampip7od	38	30	e.g.	e.g.	RB
cord-000257-ampip7od	38	31	,	,	,
cord-000257-ampip7od	38	32	Maximum	Maximum	NNP
cord-000257-ampip7od	38	33	Likelyhood	Likelyhood	NNP
cord-000257-ampip7od	38	34	and	and	CC
cord-000257-ampip7od	38	35	Bayesian	bayesian	JJ
cord-000257-ampip7od	38	36	estimation	estimation	NN
cord-000257-ampip7od	38	37	)	)	-RRB-
cord-000257-ampip7od	38	38	,	,	,
cord-000257-ampip7od	38	39	which	which	WDT
cord-000257-ampip7od	38	40	are	be	VBP
cord-000257-ampip7od	38	41	calibrated	calibrate	VBN
cord-000257-ampip7od	38	42	with	with	IN
cord-000257-ampip7od	38	43	additional	additional	JJ
cord-000257-ampip7od	38	44	evidence	evidence	NN
cord-000257-ampip7od	38	45	Fig	fig	NN
cord-000257-ampip7od	38	46	.	.	.
cord-000257-ampip7od	39	1	(	(	-LRB-
cord-000257-ampip7od	39	2	1A	1a	NN
cord-000257-ampip7od	39	3	)	)	-RRB-
cord-000257-ampip7od	39	4	.	.	.
cord-000257-ampip7od	40	1	It	-PRON-	PRP
cord-000257-ampip7od	40	2	was	be	VBD
cord-000257-ampip7od	40	3	computed	compute	VBN
cord-000257-ampip7od	40	4	using	use	VBG
cord-000257-ampip7od	40	5	Bayesian	bayesian	JJ
cord-000257-ampip7od	40	6	estimation	estimation	NN
cord-000257-ampip7od	40	7	and	and	CC
cord-000257-ampip7od	40	8	presents	present	VBZ
cord-000257-ampip7od	40	9	the	the	DT
cord-000257-ampip7od	40	10	best	well	RBS
cord-000257-ampip7od	40	11	-	-	HYPH
cord-000257-ampip7od	40	12	supported	support	VBN
cord-000257-ampip7od	40	13	topology	topology	NN
cord-000257-ampip7od	40	14	for	for	IN
cord-000257-ampip7od	40	15	the	the	DT
cord-000257-ampip7od	40	16	alignment	alignment	NN
cord-000257-ampip7od	40	17	.	.	.
cord-000257-ampip7od	41	1	Numbers	number	NNS
cord-000257-ampip7od	41	2	indicate	indicate	VBP
cord-000257-ampip7od	41	3	%	%	NN
cord-000257-ampip7od	41	4	support	support	NN
cord-000257-ampip7od	41	5	by	by	IN
cord-000257-ampip7od	41	6	the	the	DT
cord-000257-ampip7od	41	7	two	two	CD
cord-000257-ampip7od	41	8	methods	method	NNS
cord-000257-ampip7od	41	9	used	use	VBN
cord-000257-ampip7od	41	10	,	,	,
cord-000257-ampip7od	41	11	while	while	IN
cord-000257-ampip7od	41	12	#	#	NN
cord-000257-ampip7od	41	13	indicates	indicate	VBZ
cord-000257-ampip7od	41	14	gene	gene	NN
cord-000257-ampip7od	41	15	duplication	duplication	NN
cord-000257-ampip7od	41	16	events	event	NNS
cord-000257-ampip7od	41	17	in	in	IN
cord-000257-ampip7od	41	18	the	the	DT
cord-000257-ampip7od	41	19	common	common	JJ
cord-000257-ampip7od	41	20	ancestor	ancestor	NN
cord-000257-ampip7od	41	21	and	and	CC
cord-000257-ampip7od	41	22	*	*	NFP
cord-000257-ampip7od	41	23	marks	mark	VBZ
cord-000257-ampip7od	41	24	a	a	DT
cord-000257-ampip7od	41	25	species	species	NN
cord-000257-ampip7od	41	26	-	-	HYPH
cord-000257-ampip7od	41	27	specific	specific	JJ
cord-000257-ampip7od	41	28	duplication	duplication	NN
cord-000257-ampip7od	41	29	event	event	NN
cord-000257-ampip7od	41	30	.	.	.
cord-000257-ampip7od	42	1	For	for	IN
cord-000257-ampip7od	42	2	computational	computational	JJ
cord-000257-ampip7od	42	3	details	detail	NNS
cord-000257-ampip7od	42	4	,	,	,
cord-000257-ampip7od	42	5	please	please	UH
cord-000257-ampip7od	42	6	see	see	VB
cord-000257-ampip7od	42	7	[	[	-LRB-
cord-000257-ampip7od	42	8	42	42	CD
cord-000257-ampip7od	42	9	]	]	-RRB-
cord-000257-ampip7od	42	10	.	.	.
cord-000257-ampip7od	43	1	such	such	JJ
cord-000257-ampip7od	43	2	as	as	IN
cord-000257-ampip7od	43	3	fossils	fossil	NNS
cord-000257-ampip7od	43	4	and	and	CC
cord-000257-ampip7od	43	5	may	may	MD
cord-000257-ampip7od	43	6	therefore	therefore	RB
cord-000257-ampip7od	43	7	also	also	RB
cord-000257-ampip7od	43	8	provide	provide	VB
cord-000257-ampip7od	43	9	valuable	valuable	JJ
cord-000257-ampip7od	43	10	information	information	NN
cord-000257-ampip7od	43	11	on	on	IN
cord-000257-ampip7od	43	12	aspects	aspect	NNS
cord-000257-ampip7od	43	13	like	like	IN
cord-000257-ampip7od	43	14	divergence	divergence	NN
cord-000257-ampip7od	43	15	times	time	NNS
cord-000257-ampip7od	43	16	and	and	CC
cord-000257-ampip7od	43	17	ancestral	ancestral	JJ
cord-000257-ampip7od	43	18	sequences	sequence	NNS
cord-000257-ampip7od	43	19	[	[	-LRB-
cord-000257-ampip7od	43	20	36	36	CD
cord-000257-ampip7od	43	21	]	]	-RRB-
cord-000257-ampip7od	43	22	[	[	-LRB-
cord-000257-ampip7od	43	23	37	37	CD
cord-000257-ampip7od	43	24	]	]	-RRB-
cord-000257-ampip7od	43	25	[	[	-LRB-
cord-000257-ampip7od	43	26	38	38	CD
cord-000257-ampip7od	43	27	]	]	-RRB-
cord-000257-ampip7od	43	28	.	.	.
cord-000257-ampip7od	44	1	Commonly	commonly	RB
cord-000257-ampip7od	44	2	used	use	VBN
cord-000257-ampip7od	44	3	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	44	4	analysis	analysis	NN
cord-000257-ampip7od	44	5	strategies	strategy	NNS
cord-000257-ampip7od	44	6	are	be	VBP
cord-000257-ampip7od	44	7	listed	list	VBN
cord-000257-ampip7od	44	8	in	in	IN
cord-000257-ampip7od	44	9	Table	Table	NNP
cord-000257-ampip7od	44	10	1	1	CD
cord-000257-ampip7od	44	11	.	.	.
cord-000257-ampip7od	45	1	A	a	DT
cord-000257-ampip7od	45	2	limitation	limitation	NN
cord-000257-ampip7od	45	3	of	of	IN
cord-000257-ampip7od	45	4	all	all	DT
cord-000257-ampip7od	45	5	inferred	infer	VBN
cord-000257-ampip7od	45	6	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	45	7	data	datum	NNS
cord-000257-ampip7od	45	8	is	be	VBZ
cord-000257-ampip7od	45	9	that	that	IN
cord-000257-ampip7od	45	10	it	-PRON-	PRP
cord-000257-ampip7od	45	11	is	be	VBZ
cord-000257-ampip7od	45	12	directly	directly	RB
cord-000257-ampip7od	45	13	dependent	dependent	JJ
cord-000257-ampip7od	45	14	on	on	IN
cord-000257-ampip7od	45	15	the	the	DT
cord-000257-ampip7od	45	16	alignment	alignment	NN
cord-000257-ampip7od	45	17	and	and	CC
cord-000257-ampip7od	45	18	less	less	RBR
cord-000257-ampip7od	45	19	so	so	RB
cord-000257-ampip7od	45	20	on	on	IN
cord-000257-ampip7od	45	21	the	the	DT
cord-000257-ampip7od	45	22	programs	program	NNS
cord-000257-ampip7od	45	23	used	use	VBN
cord-000257-ampip7od	45	24	to	to	TO
cord-000257-ampip7od	45	25	build	build	VB
cord-000257-ampip7od	45	26	the	the	DT
cord-000257-ampip7od	45	27	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	45	28	tree	tree	NN
cord-000257-ampip7od	45	29	[	[	-LRB-
cord-000257-ampip7od	45	30	39	39	CD
cord-000257-ampip7od	45	31	]	]	-RRB-
cord-000257-ampip7od	45	32	.	.	.
cord-000257-ampip7od	46	1	One	one	CD
cord-000257-ampip7od	46	2	of	of	IN
cord-000257-ampip7od	46	3	the	the	DT
cord-000257-ampip7od	46	4	shortcomings	shortcoming	NNS
cord-000257-ampip7od	46	5	of	of	IN
cord-000257-ampip7od	46	6	automated	automate	VBN
cord-000257-ampip7od	46	7	alignments	alignment	NNS
cord-000257-ampip7od	46	8	may	may	MD
cord-000257-ampip7od	46	9	thus	thus	RB
cord-000257-ampip7od	46	10	derive	derive	VB
cord-000257-ampip7od	46	11	from	from	IN
cord-000257-ampip7od	46	12	the	the	DT
cord-000257-ampip7od	46	13	fact	fact	NN
cord-000257-ampip7od	46	14	that	that	IN
cord-000257-ampip7od	46	15	they	-PRON-	PRP
cord-000257-ampip7od	46	16	commonly	commonly	RB
cord-000257-ampip7od	46	17	employ	employ	VBP
cord-000257-ampip7od	46	18	a	a	DT
cord-000257-ampip7od	46	19	scoring	scoring	NN
cord-000257-ampip7od	46	20	and	and	CC
cord-000257-ampip7od	46	21	penalty	penalty	NN
cord-000257-ampip7od	46	22	procedure	procedure	NN
cord-000257-ampip7od	46	23	to	to	TO
cord-000257-ampip7od	46	24	find	find	VB
cord-000257-ampip7od	46	25	the	the	DT
cord-000257-ampip7od	46	26	best	good	JJS
cord-000257-ampip7od	46	27	possible	possible	JJ
cord-000257-ampip7od	46	28	alignment	alignment	NN
cord-000257-ampip7od	46	29	,	,	,
cord-000257-ampip7od	46	30	since	since	IN
cord-000257-ampip7od	46	31	these	these	DT
cord-000257-ampip7od	46	32	parameters	parameter	NNS
cord-000257-ampip7od	46	33	vary	vary	VBP
cord-000257-ampip7od	46	34	from	from	IN
cord-000257-ampip7od	46	35	species	specie	NNS
cord-000257-ampip7od	46	36	to	to	IN
cord-000257-ampip7od	46	37	species	specie	NNS
cord-000257-ampip7od	46	38	[	[	-LRB-
cord-000257-ampip7od	46	39	22	22	CD
cord-000257-ampip7od	46	40	,	,	,
cord-000257-ampip7od	46	41	23	23	CD
cord-000257-ampip7od	46	42	]	]	-RRB-
cord-000257-ampip7od	46	43	,	,	,
cord-000257-ampip7od	46	44	as	as	IN
cord-000257-ampip7od	46	45	mentioned	mention	VBN
cord-000257-ampip7od	46	46	above	above	RB
cord-000257-ampip7od	46	47	.	.	.
cord-000257-ampip7od	47	1	Careful	careful	JJ
cord-000257-ampip7od	47	2	inspection	inspection	NN
cord-000257-ampip7od	47	3	of	of	IN
cord-000257-ampip7od	47	4	alignments	alignment	NNS
cord-000257-ampip7od	47	5	is	be	VBZ
cord-000257-ampip7od	47	6	therefore	therefore	RB
cord-000257-ampip7od	47	7	advisable	advisable	JJ
cord-000257-ampip7od	47	8	,	,	,
cord-000257-ampip7od	47	9	even	even	RB
cord-000257-ampip7od	47	10	though	though	IN
cord-000257-ampip7od	47	11	software	software	NN
cord-000257-ampip7od	47	12	has	have	VBZ
cord-000257-ampip7od	47	13	been	be	VBN
cord-000257-ampip7od	47	14	developed	develop	VBN
cord-000257-ampip7od	47	15	that	that	WDT
cord-000257-ampip7od	47	16	combines	combine	VBZ
cord-000257-ampip7od	47	17	the	the	DT
cord-000257-ampip7od	47	18	alignment	alignment	NN
cord-000257-ampip7od	47	19	procedure	procedure	NN
cord-000257-ampip7od	47	20	and	and	CC
cord-000257-ampip7od	47	21	phylogenetic	phylogenetic	NN
cord-000257-ampip7od	47	22	analysis	analysis	NN
cord-000257-ampip7od	47	23	iteratively	iteratively	RB
cord-000257-ampip7od	47	24	in	in	IN
cord-000257-ampip7od	47	25	one	one	CD
cord-000257-ampip7od	47	26	single	single	JJ
cord-000257-ampip7od	47	27	program	program	NN
cord-000257-ampip7od	47	28	[	[	-LRB-
cord-000257-ampip7od	47	29	40	40	CD
cord-000257-ampip7od	47	30	]	]	-RRB-
cord-000257-ampip7od	47	31	.	.	.
cord-000257-ampip7od	48	1	Although	although	IN
cord-000257-ampip7od	48	2	sequence	sequence	NN
cord-000257-ampip7od	48	3	and	and	CC
cord-000257-ampip7od	48	4	phylogenetic	phylogenetic	NN
cord-000257-ampip7od	48	5	analysis	analysis	NN
cord-000257-ampip7od	48	6	provide	provide	VBP
cord-000257-ampip7od	48	7	a	a	DT
cord-000257-ampip7od	48	8	relatively	relatively	RB
cord-000257-ampip7od	48	9	straightforward	straightforward	JJ
cord-000257-ampip7od	48	10	way	way	NN
cord-000257-ampip7od	48	11	for	for	IN
cord-000257-ampip7od	48	12	looking	look	VBG
cord-000257-ampip7od	48	13	at	at	IN
cord-000257-ampip7od	48	14	domain	domain	NN
cord-000257-ampip7od	48	15	divergence	divergence	NN
cord-000257-ampip7od	48	16	,	,	,
cord-000257-ampip7od	48	17	comparison	comparison	NN
cord-000257-ampip7od	48	18	of	of	IN
cord-000257-ampip7od	48	19	solved	solve	VBN
cord-000257-ampip7od	48	20	protein	protein	NN
cord-000257-ampip7od	48	21	structures	structure	NNS
cord-000257-ampip7od	48	22	has	have	VBZ
cord-000257-ampip7od	48	23	shown	show	VBN
cord-000257-ampip7od	48	24	that	that	IN
cord-000257-ampip7od	48	25	protein	protein	NN
cord-000257-ampip7od	48	26	tertiary	tertiary	JJ
cord-000257-ampip7od	48	27	organizations	organization	NNS
cord-000257-ampip7od	48	28	are	be	VBP
cord-000257-ampip7od	48	29	much	much	RB
cord-000257-ampip7od	48	30	more	more	RBR
cord-000257-ampip7od	48	31	conserved	conserved	JJ
cord-000257-ampip7od	48	32	(	(	-LRB-
cord-000257-ampip7od	48	33	>	>	NFP
cord-000257-ampip7od	48	34	50	50	CD
cord-000257-ampip7od	48	35	%	%	NN
cord-000257-ampip7od	48	36	)	)	-RRB-
cord-000257-ampip7od	48	37	than	than	IN
cord-000257-ampip7od	48	38	their	-PRON-	PRP$
cord-000257-ampip7od	48	39	primary	primary	JJ
cord-000257-ampip7od	48	40	sequence	sequence	NN
cord-000257-ampip7od	48	41	(	(	-LRB-
cord-000257-ampip7od	48	42	>	>	NFP
cord-000257-ampip7od	48	43	5	5	CD
cord-000257-ampip7od	48	44	%	%	NN
cord-000257-ampip7od	48	45	)	)	-RRB-
cord-000257-ampip7od	48	46	[	[	-LRB-
cord-000257-ampip7od	48	47	41	41	CD
cord-000257-ampip7od	48	48	]	]	-RRB-
cord-000257-ampip7od	48	49	.	.	.
cord-000257-ampip7od	49	1	For	for	IN
cord-000257-ampip7od	49	2	this	this	DT
cord-000257-ampip7od	49	3	reason	reason	NN
cord-000257-ampip7od	49	4	,	,	,
cord-000257-ampip7od	49	5	protein	protein	NN
cord-000257-ampip7od	49	6	structures	structure	NNS
cord-000257-ampip7od	49	7	and	and	CC
cord-000257-ampip7od	49	8	their	-PRON-	PRP$
cord-000257-ampip7od	49	9	models	model	NNS
cord-000257-ampip7od	49	10	provide	provide	VBP
cord-000257-ampip7od	49	11	significantly	significantly	RB
cord-000257-ampip7od	49	12	more	more	JJR
cord-000257-ampip7od	49	13	insight	insight	NN
cord-000257-ampip7od	49	14	into	into	IN
cord-000257-ampip7od	49	15	the	the	DT
cord-000257-ampip7od	49	16	relations	relation	NNS
cord-000257-ampip7od	49	17	of	of	IN
cord-000257-ampip7od	49	18	protein	protein	NN
cord-000257-ampip7od	49	19	domains	domain	NNS
cord-000257-ampip7od	49	20	and	and	CC
cord-000257-ampip7od	49	21	how	how	WRB
cord-000257-ampip7od	49	22	domain	domain	NN
cord-000257-ampip7od	49	23	families	family	NNS
cord-000257-ampip7od	49	24	diverged	diverge	VBD
cord-000257-ampip7od	49	25	[	[	-LRB-
cord-000257-ampip7od	49	26	16	16	CD
cord-000257-ampip7od	49	27	]	]	-RRB-
cord-000257-ampip7od	49	28	.	.	.
cord-000257-ampip7od	50	1	For	for	IN
cord-000257-ampip7od	50	2	example	example	NN
cord-000257-ampip7od	50	3	,	,	,
cord-000257-ampip7od	50	4	the	the	DT
cord-000257-ampip7od	50	5	inactive	inactive	JJ
cord-000257-ampip7od	50	6	guanylate	guanylate	NN
cord-000257-ampip7od	50	7	kinase	kinase	NN
cord-000257-ampip7od	50	8	(	(	-LRB-
cord-000257-ampip7od	50	9	GK	GK	NNP
cord-000257-ampip7od	50	10	)	)	-RRB-
cord-000257-ampip7od	50	11	domain	domain	NN
cord-000257-ampip7od	50	12	present	present	JJ
cord-000257-ampip7od	50	13	in	in	IN
cord-000257-ampip7od	50	14	the	the	DT
cord-000257-ampip7od	50	15	MAGUK	MAGUK	NNP
cord-000257-ampip7od	50	16	family	family	NN
cord-000257-ampip7od	50	17	was	be	VBD
cord-000257-ampip7od	50	18	shown	show	VBN
cord-000257-ampip7od	50	19	to	to	TO
cord-000257-ampip7od	50	20	originate	originate	VB
cord-000257-ampip7od	50	21	from	from	IN
cord-000257-ampip7od	50	22	an	an	DT
cord-000257-ampip7od	50	23	active	active	JJ
cord-000257-ampip7od	50	24	form	form	NN
cord-000257-ampip7od	50	25	of	of	IN
cord-000257-ampip7od	50	26	the	the	DT
cord-000257-ampip7od	50	27	GK	GK	NNP
cord-000257-ampip7od	50	28	domain	domain	NN
cord-000257-ampip7od	50	29	residing	reside	VBG
cord-000257-ampip7od	50	30	in	in	IN
cord-000257-ampip7od	50	31	Ca2	ca2	CD
cord-000257-ampip7od	50	32	+	+	CC
cord-000257-ampip7od	51	1	channel	channel	NNP
cord-000257-ampip7od	51	2	beta	beta	NN
cord-000257-ampip7od	51	3	-	-	HYPH
cord-000257-ampip7od	51	4	subunits	subunit	NNS
cord-000257-ampip7od	51	5	(	(	-LRB-
cord-000257-ampip7od	51	6	CACNBs	CACNBs	NNP
cord-000257-ampip7od	51	7	)	)	-RRB-
cord-000257-ampip7od	51	8	through	through	IN
cord-000257-ampip7od	51	9	both	both	DT
cord-000257-ampip7od	51	10	sequence	sequence	NN
cord-000257-ampip7od	51	11	and	and	CC
cord-000257-ampip7od	51	12	structural	structural	JJ
cord-000257-ampip7od	51	13	comparison	comparison	NN
cord-000257-ampip7od	51	14	[	[	-LRB-
cord-000257-ampip7od	51	15	42	42	CD
cord-000257-ampip7od	51	16	]	]	-RRB-
cord-000257-ampip7od	51	17	.	.	.
cord-000257-ampip7od	52	1	Furthermore	furthermore	RB
cord-000257-ampip7od	52	2	,	,	,
cord-000257-ampip7od	52	3	identification	identification	NN
cord-000257-ampip7od	52	4	of	of	IN
cord-000257-ampip7od	52	5	functionally	functionally	RB
cord-000257-ampip7od	52	6	or	or	CC
cord-000257-ampip7od	52	7	structurally	structurally	RB
cord-000257-ampip7od	52	8	related	related	JJ
cord-000257-ampip7od	52	9	amino	amino	NN
cord-000257-ampip7od	52	10	acid	acid	NN
cord-000257-ampip7od	52	11	sites	site	NNS
cord-000257-ampip7od	52	12	in	in	IN
cord-000257-ampip7od	52	13	a	a	DT
cord-000257-ampip7od	52	14	fold	fold	NN
cord-000257-ampip7od	52	15	sheds	shed	VBZ
cord-000257-ampip7od	52	16	light	light	NN
cord-000257-ampip7od	52	17	on	on	IN
cord-000257-ampip7od	52	18	the	the	DT
cord-000257-ampip7od	52	19	complex	complex	JJ
cord-000257-ampip7od	52	20	,	,	,
cord-000257-ampip7od	52	21	co	co	JJ
cord-000257-ampip7od	52	22	-	-	JJ
cord-000257-ampip7od	52	23	evolutionary	evolutionary	JJ
cord-000257-ampip7od	52	24	dynamics	dynamic	NNS
cord-000257-ampip7od	52	25	that	that	WDT
cord-000257-ampip7od	52	26	took	take	VBD
cord-000257-ampip7od	52	27	place	place	NN
cord-000257-ampip7od	52	28	during	during	IN
cord-000257-ampip7od	52	29	selection	selection	NN
cord-000257-ampip7od	52	30	[	[	-LRB-
cord-000257-ampip7od	52	31	43	43	CD
cord-000257-ampip7od	52	32	]	]	-RRB-
cord-000257-ampip7od	52	33	.	.	.
cord-000257-ampip7od	53	1	As	as	IN
cord-000257-ampip7od	53	2	described	describe	VBN
cord-000257-ampip7od	53	3	above	above	RB
cord-000257-ampip7od	53	4	,	,	,
cord-000257-ampip7od	53	5	the	the	DT
cord-000257-ampip7od	53	6	evolution	evolution	NN
cord-000257-ampip7od	53	7	of	of	IN
cord-000257-ampip7od	53	8	a	a	DT
cord-000257-ampip7od	53	9	protein	protein	NN
cord-000257-ampip7od	53	10	domain	domain	NN
cord-000257-ampip7od	53	11	is	be	VBZ
cord-000257-ampip7od	53	12	generally	generally	RB
cord-000257-ampip7od	53	13	the	the	DT
cord-000257-ampip7od	53	14	result	result	NN
cord-000257-ampip7od	53	15	of	of	IN
cord-000257-ampip7od	53	16	a	a	DT
cord-000257-ampip7od	53	17	combination	combination	NN
cord-000257-ampip7od	53	18	of	of	IN
cord-000257-ampip7od	53	19	a	a	DT
cord-000257-ampip7od	53	20	series	series	NN
cord-000257-ampip7od	53	21	of	of	IN
cord-000257-ampip7od	53	22	random	random	JJ
cord-000257-ampip7od	53	23	mutations	mutation	NNS
cord-000257-ampip7od	53	24	and	and	CC
cord-000257-ampip7od	53	25	a	a	DT
cord-000257-ampip7od	53	26	selection	selection	NN
cord-000257-ampip7od	53	27	constraint	constraint	NN
cord-000257-ampip7od	53	28	imposed	impose	VBN
cord-000257-ampip7od	53	29	on	on	IN
cord-000257-ampip7od	53	30	function	function	NN
cord-000257-ampip7od	53	31	,	,	,
cord-000257-ampip7od	53	32	i.e.	i.e.	FW
cord-000257-ampip7od	53	33	,	,	,
cord-000257-ampip7od	53	34	the	the	DT
cord-000257-ampip7od	53	35	interaction	interaction	NN
cord-000257-ampip7od	53	36	with	with	IN
cord-000257-ampip7od	53	37	a	a	DT
cord-000257-ampip7od	53	38	ligand	ligand	NN
cord-000257-ampip7od	53	39	.	.	.
cord-000257-ampip7od	54	1	The	the	DT
cord-000257-ampip7od	54	2	interaction	interaction	NN
cord-000257-ampip7od	54	3	between	between	IN
cord-000257-ampip7od	54	4	protein	protein	NN
cord-000257-ampip7od	54	5	and	and	CC
cord-000257-ampip7od	54	6	ligand	ligand	NN
cord-000257-ampip7od	54	7	can	can	MD
cord-000257-ampip7od	54	8	be	be	VB
cord-000257-ampip7od	54	9	imagined	imagine	VBN
cord-000257-ampip7od	54	10	as	as	IN
cord-000257-ampip7od	54	11	disturbances	disturbance	NNS
cord-000257-ampip7od	54	12	of	of	IN
cord-000257-ampip7od	54	13	the	the	DT
cord-000257-ampip7od	54	14	protein	protein	NN
cord-000257-ampip7od	54	15	's	's	POS
cord-000257-ampip7od	54	16	energy	energy	NN
cord-000257-ampip7od	54	17	landscape	landscape	NN
cord-000257-ampip7od	54	18	,	,	,
cord-000257-ampip7od	54	19	which	which	WDT
cord-000257-ampip7od	54	20	in	in	IN
cord-000257-ampip7od	54	21	turn	turn	NN
cord-000257-ampip7od	54	22	bring	bring	VBP
cord-000257-ampip7od	54	23	about	about	RP
cord-000257-ampip7od	54	24	specific	specific	JJ
cord-000257-ampip7od	54	25	,	,	,
cord-000257-ampip7od	54	26	three	three	CD
cord-000257-ampip7od	54	27	-	-	HYPH
cord-000257-ampip7od	54	28	dimensional	dimensional	JJ
cord-000257-ampip7od	54	29	changes	change	NNS
cord-000257-ampip7od	54	30	in	in	IN
cord-000257-ampip7od	54	31	the	the	DT
cord-000257-ampip7od	54	32	protein	protein	NN
cord-000257-ampip7od	54	33	structure	structure	NN
cord-000257-ampip7od	54	34	[	[	-LRB-
cord-000257-ampip7od	54	35	44	44	CD
cord-000257-ampip7od	54	36	,	,	,
cord-000257-ampip7od	54	37	45	45	CD
cord-000257-ampip7od	54	38	]	]	-RRB-
cord-000257-ampip7od	54	39	.	.	.
cord-000257-ampip7od	55	1	Binding	bind	VBG
cord-000257-ampip7od	55	2	energies	energy	NNS
cord-000257-ampip7od	55	3	however	however	RB
cord-000257-ampip7od	55	4	,	,	,
cord-000257-ampip7od	55	5	need	nee	MD
cord-000257-ampip7od	55	6	not	not	RB
cord-000257-ampip7od	55	7	be	be	VB
cord-000257-ampip7od	55	8	smoothly	smoothly	RB
cord-000257-ampip7od	55	9	distributed	distribute	VBN
cord-000257-ampip7od	55	10	over	over	IN
cord-000257-ampip7od	55	11	the	the	DT
cord-000257-ampip7od	55	12	protein	protein	NN
cord-000257-ampip7od	55	13	's	's	POS
cord-000257-ampip7od	55	14	binding	bind	VBG
cord-000257-ampip7od	55	15	pocket	pocket	NN
cord-000257-ampip7od	55	16	as	as	IN
cord-000257-ampip7od	55	17	a	a	DT
cord-000257-ampip7od	55	18	limited	limited	JJ
cord-000257-ampip7od	55	19	number	number	NN
cord-000257-ampip7od	55	20	of	of	IN
cord-000257-ampip7od	55	21	amino	amino	JJ
cord-000257-ampip7od	55	22	acids	acid	NNS
cord-000257-ampip7od	55	23	may	may	MD
cord-000257-ampip7od	55	24	account	account	VB
cord-000257-ampip7od	55	25	for	for	IN
cord-000257-ampip7od	55	26	most	most	JJS
cord-000257-ampip7od	55	27	of	of	IN
cord-000257-ampip7od	55	28	the	the	DT
cord-000257-ampip7od	55	29	free	free	JJ
cord-000257-ampip7od	55	30	-	-	HYPH
cord-000257-ampip7od	55	31	energy	energy	NN
cord-000257-ampip7od	55	32	change	change	NN
cord-000257-ampip7od	55	33	that	that	WDT
cord-000257-ampip7od	55	34	occurs	occur	VBZ
cord-000257-ampip7od	55	35	upon	upon	IN
cord-000257-ampip7od	55	36	binding	bind	VBG
cord-000257-ampip7od	55	37	[	[	-LRB-
cord-000257-ampip7od	55	38	45	45	CD
cord-000257-ampip7od	55	39	]	]	-RRB-
cord-000257-ampip7od	56	1	[	[	-LRB-
cord-000257-ampip7od	56	2	46	46	CD
cord-000257-ampip7od	56	3	]	]	-RRB-
cord-000257-ampip7od	56	4	[	[	-LRB-
cord-000257-ampip7od	56	5	47	47	CD
cord-000257-ampip7od	56	6	]	]	-RRB-
cord-000257-ampip7od	56	7	.	.	.
cord-000257-ampip7od	57	1	In	in	IN
cord-000257-ampip7od	57	2	these	these	DT
cord-000257-ampip7od	57	3	cases	case	NNS
cord-000257-ampip7od	57	4	,	,	,
cord-000257-ampip7od	57	5	new	new	JJ
cord-000257-ampip7od	57	6	binding	binding	NN
cord-000257-ampip7od	57	7	specificities	specificity	NNS
cord-000257-ampip7od	57	8	(	(	-LRB-
cord-000257-ampip7od	57	9	including	include	VBG
cord-000257-ampip7od	57	10	loss	loss	NN
cord-000257-ampip7od	57	11	of	of	IN
cord-000257-ampip7od	57	12	binding	bind	VBG
cord-000257-ampip7od	57	13	)	)	-RRB-
cord-000257-ampip7od	57	14	may	may	MD
cord-000257-ampip7od	57	15	therefore	therefore	RB
cord-000257-ampip7od	57	16	arise	arise	VB
cord-000257-ampip7od	57	17	through	through	IN
cord-000257-ampip7od	57	18	mutations	mutation	NNS
cord-000257-ampip7od	57	19	at	at	IN
cord-000257-ampip7od	57	20	these	these	DT
cord-000257-ampip7od	57	21	hot	hot	JJ
cord-000257-ampip7od	57	22	spots	spot	NNS
cord-000257-ampip7od	57	23	.	.	.
cord-000257-ampip7od	58	1	An	an	DT
cord-000257-ampip7od	58	2	example	example	NN
cord-000257-ampip7od	58	3	is	be	VBZ
cord-000257-ampip7od	58	4	a	a	DT
cord-000257-ampip7od	58	5	recent	recent	JJ
cord-000257-ampip7od	58	6	study	study	NN
cord-000257-ampip7od	58	7	of	of	IN
cord-000257-ampip7od	58	8	the	the	DT
cord-000257-ampip7od	58	9	PDZ	PDZ	NNP
cord-000257-ampip7od	58	10	domain	domain	NN
cord-000257-ampip7od	58	11	in	in	IN
cord-000257-ampip7od	58	12	which	which	WDT
cord-000257-ampip7od	58	13	it	-PRON-	PRP
cord-000257-ampip7od	58	14	was	be	VBD
cord-000257-ampip7od	58	15	shown	show	VBN
cord-000257-ampip7od	58	16	that	that	IN
cord-000257-ampip7od	58	17	only	only	RB
cord-000257-ampip7od	58	18	a	a	DT
cord-000257-ampip7od	58	19	selected	select	VBN
cord-000257-ampip7od	58	20	set	set	NN
cord-000257-ampip7od	58	21	of	of	IN
cord-000257-ampip7od	58	22	residues	residue	NNS
cord-000257-ampip7od	58	23	,	,	,
cord-000257-ampip7od	58	24	and	and	CC
cord-000257-ampip7od	58	25	in	in	IN
cord-000257-ampip7od	58	26	particular	particular	JJ
cord-000257-ampip7od	58	27	the	the	DT
cord-000257-ampip7od	58	28	first	first	JJ
cord-000257-ampip7od	58	29	residue	residue	NN
cord-000257-ampip7od	58	30	of	of	IN
cord-000257-ampip7od	58	31	-helix	-helix	JJ
cord-000257-ampip7od	58	32	2	2	CD
cord-000257-ampip7od	58	33	(	(	-LRB-
cord-000257-ampip7od	58	34	B1	b1	NN
cord-000257-ampip7od	58	35	)	)	-RRB-
cord-000257-ampip7od	58	36	,	,	,
cord-000257-ampip7od	58	37	directly	directly	RB
cord-000257-ampip7od	58	38	confers	confer	VBZ
cord-000257-ampip7od	58	39	binding	bind	VBG
cord-000257-ampip7od	58	40	to	to	IN
cord-000257-ampip7od	58	41	a	a	DT
cord-000257-ampip7od	58	42	set	set	NN
cord-000257-ampip7od	58	43	of	of	IN
cord-000257-ampip7od	58	44	C	c	NN
cord-000257-ampip7od	58	45	-	-	HYPH
cord-000257-ampip7od	58	46	terminal	terminal	NN
cord-000257-ampip7od	58	47	peptides	peptide	NNS
cord-000257-ampip7od	58	48	[	[	-LRB-
cord-000257-ampip7od	58	49	48	48	CD
cord-000257-ampip7od	58	50	]	]	-RRB-
cord-000257-ampip7od	58	51	.	.	.
cord-000257-ampip7od	59	1	The	the	DT
cord-000257-ampip7od	59	2	folding	folding	NN
cord-000257-ampip7od	59	3	of	of	IN
cord-000257-ampip7od	59	4	a	a	DT
cord-000257-ampip7od	59	5	domain	domain	NN
cord-000257-ampip7od	59	6	is	be	VBZ
cord-000257-ampip7od	59	7	essentially	essentially	RB
cord-000257-ampip7od	59	8	based	base	VBN
cord-000257-ampip7od	59	9	on	on	IN
cord-000257-ampip7od	59	10	a	a	DT
cord-000257-ampip7od	59	11	complex	complex	JJ
cord-000257-ampip7od	59	12	network	network	NN
cord-000257-ampip7od	59	13	of	of	IN
cord-000257-ampip7od	59	14	sequential	sequential	JJ
cord-000257-ampip7od	59	15	inter	inter	JJ
cord-000257-ampip7od	59	16	-	-	JJ
cord-000257-ampip7od	59	17	molecular	molecular	JJ
cord-000257-ampip7od	59	18	interactions	interaction	NNS
cord-000257-ampip7od	59	19	in	in	IN
cord-000257-ampip7od	59	20	time	time	NN
cord-000257-ampip7od	59	21	[	[	-LRB-
cord-000257-ampip7od	59	22	49	49	CD
cord-000257-ampip7od	59	23	]	]	-RRB-
cord-000257-ampip7od	59	24	.	.	.
cord-000257-ampip7od	60	1	This	this	DT
cord-000257-ampip7od	60	2	has	have	VBZ
cord-000257-ampip7od	60	3	of	of	IN
cord-000257-ampip7od	60	4	course	course	NN
cord-000257-ampip7od	60	5	significant	significant	JJ
cord-000257-ampip7od	60	6	implications	implication	NNS
cord-000257-ampip7od	60	7	for	for	IN
cord-000257-ampip7od	60	8	domain	domain	NN
cord-000257-ampip7od	60	9	integrity	integrity	NN
cord-000257-ampip7od	60	10	,	,	,
cord-000257-ampip7od	60	11	particularly	particularly	RB
cord-000257-ampip7od	60	12	if	if	IN
cord-000257-ampip7od	60	13	one	one	PRP
cord-000257-ampip7od	60	14	assumes	assume	VBZ
cord-000257-ampip7od	60	15	that	that	IN
cord-000257-ampip7od	60	16	the	the	DT
cord-000257-ampip7od	60	17	core	core	NN
cord-000257-ampip7od	60	18	of	of	IN
cord-000257-ampip7od	60	19	a	a	DT
cord-000257-ampip7od	60	20	protein	protein	NN
cord-000257-ampip7od	60	21	domain	domain	NN
cord-000257-ampip7od	60	22	is	be	VBZ
cord-000257-ampip7od	60	23	and	and	CC
cord-000257-ampip7od	60	24	has	have	VBZ
cord-000257-ampip7od	60	25	to	to	TO
cord-000257-ampip7od	60	26	be	be	VB
cord-000257-ampip7od	60	27	largely	largely	RB
cord-000257-ampip7od	60	28	structurally	structurally	RB
cord-000257-ampip7od	60	29	conserved	conserve	VBN
cord-000257-ampip7od	60	30	.	.	.
cord-000257-ampip7od	61	1	Indeed	indeed	RB
cord-000257-ampip7od	61	2	,	,	,
cord-000257-ampip7od	61	3	even	even	RB
cord-000257-ampip7od	61	4	single	single	JJ
cord-000257-ampip7od	61	5	mutations	mutation	NNS
cord-000257-ampip7od	61	6	that	that	WDT
cord-000257-ampip7od	61	7	arise	arise	VBP
cord-000257-ampip7od	61	8	in	in	IN
cord-000257-ampip7od	61	9	this	this	DT
cord-000257-ampip7od	61	10	area	area	NN
cord-000257-ampip7od	61	11	may	may	MD
cord-000257-ampip7od	61	12	easily	easily	RB
cord-000257-ampip7od	61	13	derail	derail	VB
cord-000257-ampip7od	61	14	the	the	DT
cord-000257-ampip7od	61	15	folding	folding	NN
cord-000257-ampip7od	61	16	process	process	NN
cord-000257-ampip7od	61	17	,	,	,
cord-000257-ampip7od	61	18	either	either	CC
cord-000257-ampip7od	61	19	because	because	IN
cord-000257-ampip7od	61	20	their	-PRON-	PRP$
cord-000257-ampip7od	61	21	free	free	JJ
cord-000257-ampip7od	61	22	energy	energy	NN
cord-000257-ampip7od	61	23	contribution	contribution	NN
cord-000257-ampip7od	61	24	influences	influence	VBZ
cord-000257-ampip7od	61	25	residues	residue	NNS
cord-000257-ampip7od	61	26	in	in	IN
cord-000257-ampip7od	61	27	the	the	DT
cord-000257-ampip7od	61	28	direct	direct	JJ
cord-000257-ampip7od	61	29	vicinity	vicinity	NN
cord-000257-ampip7od	61	30	or	or	CC
cord-000257-ampip7od	61	31	disturbs	disturb	VBZ
cord-000257-ampip7od	61	32	connections	connection	NNS
cord-000257-ampip7od	61	33	higher	high	JJR
cord-000257-ampip7od	61	34	up	up	RB
cord-000257-ampip7od	61	35	in	in	IN
cord-000257-ampip7od	61	36	the	the	DT
cord-000257-ampip7od	61	37	intermolecular	intermolecular	JJ
cord-000257-ampip7od	61	38	network	network	NN
cord-000257-ampip7od	61	39	[	[	-LRB-
cord-000257-ampip7od	61	40	49	49	CD
cord-000257-ampip7od	61	41	]	]	-RRB-
cord-000257-ampip7od	61	42	.	.	.
cord-000257-ampip7od	62	1	It	-PRON-	PRP
cord-000257-ampip7od	62	2	is	be	VBZ
cord-000257-ampip7od	62	3	therefore	therefore	RB
cord-000257-ampip7od	62	4	hypothesized	hypothesize	VBN
cord-000257-ampip7od	62	5	that	that	IN
cord-000257-ampip7od	62	6	protein	protein	NN
cord-000257-ampip7od	62	7	evolution	evolution	NN
cord-000257-ampip7od	62	8	took	take	VBD
cord-000257-ampip7od	62	9	place	place	NN
cord-000257-ampip7od	62	10	at	at	IN
cord-000257-ampip7od	62	11	the	the	DT
cord-000257-ampip7od	62	12	periphery	periphery	NN
cord-000257-ampip7od	62	13	of	of	IN
cord-000257-ampip7od	62	14	the	the	DT
cord-000257-ampip7od	62	15	protein	protein	NN
cord-000257-ampip7od	62	16	domain	domain	NN
cord-000257-ampip7od	62	17	core	core	NN
cord-000257-ampip7od	62	18	,	,	,
cord-000257-ampip7od	62	19	and	and	CC
cord-000257-ampip7od	63	1	that	that	IN
cord-000257-ampip7od	63	2	gradual	gradual	JJ
cord-000257-ampip7od	63	3	changes	change	NNS
cord-000257-ampip7od	63	4	via	via	IN
cord-000257-ampip7od	63	5	point	point	NN
cord-000257-ampip7od	63	6	mutations	mutation	NNS
cord-000257-ampip7od	63	7	,	,	,
cord-000257-ampip7od	63	8	insertions	insertion	NNS
cord-000257-ampip7od	63	9	and	and	CC
cord-000257-ampip7od	63	10	deletions	deletion	NNS
cord-000257-ampip7od	63	11	in	in	IN
cord-000257-ampip7od	63	12	surface	surface	NN
cord-000257-ampip7od	63	13	loops	loop	NNS
cord-000257-ampip7od	63	14	brought	bring	VBN
cord-000257-ampip7od	63	15	about	about	IN
cord-000257-ampip7od	63	16	the	the	DT
cord-000257-ampip7od	63	17	evolutionary	evolutionary	JJ
cord-000257-ampip7od	63	18	distance	distance	NN
cord-000257-ampip7od	63	19	we	-PRON-	PRP
cord-000257-ampip7od	63	20	see	see	VBP
cord-000257-ampip7od	63	21	among	among	IN
cord-000257-ampip7od	63	22	proteins	protein	NNS
cord-000257-ampip7od	63	23	to	to	IN
cord-000257-ampip7od	63	24	date	date	NN
cord-000257-ampip7od	63	25	[	[	-LRB-
cord-000257-ampip7od	63	26	21	21	CD
cord-000257-ampip7od	63	27	,	,	,
cord-000257-ampip7od	63	28	[	[	-LRB-
cord-000257-ampip7od	63	29	50	50	CD
cord-000257-ampip7od	63	30	]	]	-RRB-
cord-000257-ampip7od	63	31	[	[	-LRB-
cord-000257-ampip7od	63	32	51	51	CD
cord-000257-ampip7od	63	33	]	]	-RRB-
cord-000257-ampip7od	63	34	[	[	-LRB-
cord-000257-ampip7od	63	35	52	52	CD
cord-000257-ampip7od	63	36	]	]	-RRB-
cord-000257-ampip7od	63	37	.	.	.
cord-000257-ampip7od	64	1	However	however	RB
cord-000257-ampip7od	64	2	,	,	,
cord-000257-ampip7od	64	3	distant	distant	JJ
cord-000257-ampip7od	64	4	sites	site	NNS
cord-000257-ampip7od	64	5	also	also	RB
cord-000257-ampip7od	64	6	contribute	contribute	VBP
cord-000257-ampip7od	64	7	to	to	IN
cord-000257-ampip7od	64	8	the	the	DT
cord-000257-ampip7od	64	9	thermodynamics	thermodynamic	NNS
cord-000257-ampip7od	64	10	of	of	IN
cord-000257-ampip7od	64	11	catalytic	catalytic	JJ
cord-000257-ampip7od	64	12	residues	residue	NNS
cord-000257-ampip7od	64	13	.	.	.
cord-000257-ampip7od	65	1	This	this	DT
cord-000257-ampip7od	65	2	is	be	VBZ
cord-000257-ampip7od	65	3	achieved	achieve	VBN
cord-000257-ampip7od	65	4	through	through	IN
cord-000257-ampip7od	65	5	a	a	DT
cord-000257-ampip7od	65	6	mechanism	mechanism	NN
cord-000257-ampip7od	65	7	called	call	VBN
cord-000257-ampip7od	65	8	energetic	energetic	JJ
cord-000257-ampip7od	65	9	coupling	coupling	NN
cord-000257-ampip7od	65	10	,	,	,
cord-000257-ampip7od	65	11	which	which	WDT
cord-000257-ampip7od	65	12	is	be	VBZ
cord-000257-ampip7od	65	13	shaped	shape	VBN
cord-000257-ampip7od	65	14	by	by	IN
cord-000257-ampip7od	65	15	a	a	DT
cord-000257-ampip7od	65	16	continuous	continuous	JJ
cord-000257-ampip7od	65	17	pathway	pathway	NN
cord-000257-ampip7od	65	18	of	of	IN
cord-000257-ampip7od	65	19	van	van	NNP
cord-000257-ampip7od	65	20	der	der	NNP
cord-000257-ampip7od	65	21	Waals	Waals	NNP
cord-000257-ampip7od	65	22	interactions	interaction	NNS
cord-000257-ampip7od	65	23	that	that	WDT
cord-000257-ampip7od	65	24	ultimately	ultimately	RB
cord-000257-ampip7od	65	25	influences	influence	VBZ
cord-000257-ampip7od	65	26	residues	residue	NNS
cord-000257-ampip7od	65	27	at	at	IN
cord-000257-ampip7od	65	28	the	the	DT
cord-000257-ampip7od	65	29	binding	binding	NN
cord-000257-ampip7od	65	30	site	site	NN
cord-000257-ampip7od	65	31	with	with	IN
cord-000257-ampip7od	65	32	similar	similar	JJ
cord-000257-ampip7od	65	33	efficiency	efficiency	NN
cord-000257-ampip7od	65	34	as	as	IN
cord-000257-ampip7od	65	35	the	the	DT
cord-000257-ampip7od	65	36	thermodynamic	thermodynamic	JJ
cord-000257-ampip7od	65	37	hotspots	hotspot	NNS
cord-000257-ampip7od	65	38	[	[	-LRB-
cord-000257-ampip7od	65	39	53	53	CD
cord-000257-ampip7od	65	40	,	,	,
cord-000257-ampip7od	65	41	54	54	CD
cord-000257-ampip7od	65	42	]	]	-RRB-
cord-000257-ampip7od	65	43	.	.	.
cord-000257-ampip7od	66	1	Indeed	indeed	RB
cord-000257-ampip7od	66	2	in	in	IN
cord-000257-ampip7od	66	3	such	such	JJ
cord-000257-ampip7od	66	4	cases	case	NNS
cord-000257-ampip7od	66	5	,	,	,
cord-000257-ampip7od	66	6	evolutionary	evolutionary	JJ
cord-000257-ampip7od	66	7	constraints	constraint	NNS
cord-000257-ampip7od	66	8	are	be	VBP
cord-000257-ampip7od	66	9	not	not	RB
cord-000257-ampip7od	66	10	placed	place	VBN
cord-000257-ampip7od	66	11	on	on	IN
cord-000257-ampip7od	66	12	merely	merely	RB
cord-000257-ampip7od	66	13	one	one	CD
cord-000257-ampip7od	66	14	amino	amino	NN
cord-000257-ampip7od	66	15	acid	acid	NN
cord-000257-ampip7od	66	16	in	in	IN
cord-000257-ampip7od	66	17	the	the	DT
cord-000257-ampip7od	66	18	binding	binding	JJ
cord-000257-ampip7od	66	19	pocket	pocket	NN
cord-000257-ampip7od	66	20	,	,	,
cord-000257-ampip7od	66	21	but	but	CC
cord-000257-ampip7od	66	22	on	on	IN
cord-000257-ampip7od	66	23	two	two	CD
cord-000257-ampip7od	66	24	or	or	CC
cord-000257-ampip7od	66	25	more	more	JJR
cord-000257-ampip7od	66	26	residues	residue	NNS
cord-000257-ampip7od	66	27	that	that	WDT
cord-000257-ampip7od	66	28	can	can	MD
cord-000257-ampip7od	66	29	be	be	VB
cord-000257-ampip7od	66	30	shown	show	VBN
cord-000257-ampip7od	66	31	to	to	TO
cord-000257-ampip7od	66	32	be	be	VB
cord-000257-ampip7od	66	33	statistically	statistically	RB
cord-000257-ampip7od	66	34	coupled	couple	VBN
cord-000257-ampip7od	66	35	in	in	IN
cord-000257-ampip7od	66	36	MSAs	msa	NNS
cord-000257-ampip7od	66	37	[	[	-LRB-
cord-000257-ampip7od	66	38	54	54	CD
cord-000257-ampip7od	66	39	,	,	,
cord-000257-ampip7od	66	40	55	55	CD
cord-000257-ampip7od	66	41	]	]	-RRB-
cord-000257-ampip7od	66	42	.	.	.
cord-000257-ampip7od	67	1	In	in	IN
cord-000257-ampip7od	67	2	addition	addition	NN
cord-000257-ampip7od	67	3	to	to	IN
cord-000257-ampip7od	67	4	contributions	contribution	NNS
cord-000257-ampip7od	67	5	to	to	IN
cord-000257-ampip7od	67	6	binding	bind	VBG
cord-000257-ampip7od	67	7	,	,	,
cord-000257-ampip7od	67	8	these	these	DT
cord-000257-ampip7od	67	9	principles	principle	NNS
cord-000257-ampip7od	67	10	also	also	RB
cord-000257-ampip7od	67	11	explain	explain	VBP
cord-000257-ampip7od	67	12	why	why	WRB
cord-000257-ampip7od	67	13	the	the	DT
cord-000257-ampip7od	67	14	core	core	NN
cord-000257-ampip7od	67	15	of	of	IN
cord-000257-ampip7od	67	16	a	a	DT
cord-000257-ampip7od	67	17	domain	domain	NN
cord-000257-ampip7od	67	18	structure	structure	NN
cord-000257-ampip7od	67	19	will	will	MD
cord-000257-ampip7od	67	20	remain	remain	VB
cord-000257-ampip7od	67	21	largely	largely	RB
cord-000257-ampip7od	67	22	conserved	conserve	VBN
cord-000257-ampip7od	67	23	,	,	,
cord-000257-ampip7od	67	24	while	while	IN
cord-000257-ampip7od	67	25	at	at	IN
cord-000257-ampip7od	67	26	functionally	functionally	RB
cord-000257-ampip7od	67	27	related	relate	VBN
cord-000257-ampip7od	67	28	places	place	NNS
cord-000257-ampip7od	67	29	residues	residue	NNS
cord-000257-ampip7od	67	30	can	can	MD
cord-000257-ampip7od	67	31	(	(	-LRB-
cord-000257-ampip7od	67	32	rapidly	rapidly	RB
cord-000257-ampip7od	67	33	)	)	-RRB-
cord-000257-ampip7od	67	34	co	co	NNS
cord-000257-ampip7od	67	35	-	-	NN
cord-000257-ampip7od	67	36	evolve	evolve	VB
cord-000257-ampip7od	67	37	with	with	IN
cord-000257-ampip7od	67	38	an	an	DT
cord-000257-ampip7od	67	39	overall	overall	JJ
cord-000257-ampip7od	67	40	neutral	neutral	JJ
cord-000257-ampip7od	67	41	effect	effect	NN
cord-000257-ampip7od	67	42	[	[	-LRB-
cord-000257-ampip7od	67	43	56	56	CD
cord-000257-ampip7od	67	44	]	]	-RRB-
cord-000257-ampip7od	67	45	.	.	.
cord-000257-ampip7od	68	1	Of	of	RB
cord-000257-ampip7od	68	2	course	course	RB
cord-000257-ampip7od	68	3	,	,	,
cord-000257-ampip7od	68	4	these	these	DT
cord-000257-ampip7od	68	5	aspects	aspect	NNS
cord-000257-ampip7od	68	6	of	of	IN
cord-000257-ampip7od	68	7	co	co	NN
cord-000257-ampip7od	68	8	-	-	NN
cord-000257-ampip7od	68	9	evolution	evolution	NN
cord-000257-ampip7od	68	10	are	be	VBP
cord-000257-ampip7od	68	11	also	also	RB
cord-000257-ampip7od	68	12	of	of	IN
cord-000257-ampip7od	68	13	practical	practical	JJ
cord-000257-ampip7od	68	14	consequence	consequence	NN
cord-000257-ampip7od	68	15	for	for	IN
cord-000257-ampip7od	68	16	structure	structure	NN
cord-000257-ampip7od	68	17	prediction	prediction	NN
cord-000257-ampip7od	68	18	and	and	CC
cord-000257-ampip7od	68	19	rational	rational	JJ
cord-000257-ampip7od	68	20	drug	drug	NN
cord-000257-ampip7od	68	21	design	design	NN
cord-000257-ampip7od	68	22	[	[	-LRB-
cord-000257-ampip7od	68	23	43	43	CD
cord-000257-ampip7od	68	24	]	]	-RRB-
cord-000257-ampip7od	68	25	.	.	.
cord-000257-ampip7od	69	1	Through	through	IN
cord-000257-ampip7od	69	2	selective	selective	JJ
cord-000257-ampip7od	69	3	mutation	mutation	NN
cord-000257-ampip7od	69	4	,	,	,
cord-000257-ampip7od	69	5	protein	protein	NN
cord-000257-ampip7od	69	6	domains	domain	NNS
cord-000257-ampip7od	69	7	have	have	VBP
cord-000257-ampip7od	69	8	been	be	VBN
cord-000257-ampip7od	69	9	the	the	DT
cord-000257-ampip7od	69	10	tools	tool	NNS
cord-000257-ampip7od	69	11	of	of	IN
cord-000257-ampip7od	69	12	evolution	evolution	NN
cord-000257-ampip7od	69	13	to	to	TO
cord-000257-ampip7od	69	14	create	create	VB
cord-000257-ampip7od	69	15	an	an	DT
cord-000257-ampip7od	69	16	enormous	enormous	JJ
cord-000257-ampip7od	69	17	and	and	CC
cord-000257-ampip7od	69	18	diverse	diverse	JJ
cord-000257-ampip7od	69	19	assembly	assembly	NN
cord-000257-ampip7od	69	20	of	of	IN
cord-000257-ampip7od	69	21	proteins	protein	NNS
cord-000257-ampip7od	69	22	from	from	IN
cord-000257-ampip7od	69	23	likely	likely	RB
cord-000257-ampip7od	69	24	an	an	DT
cord-000257-ampip7od	69	25	initially	initially	RB
cord-000257-ampip7od	69	26	relatively	relatively	RB
cord-000257-ampip7od	69	27	limited	limited	JJ
cord-000257-ampip7od	69	28	set	set	NN
cord-000257-ampip7od	69	29	of	of	IN
cord-000257-ampip7od	69	30	domains	domain	NNS
cord-000257-ampip7od	69	31	.	.	.
cord-000257-ampip7od	70	1	The	the	DT
cord-000257-ampip7od	70	2	combined	combined	JJ
cord-000257-ampip7od	70	3	data	datum	NNS
cord-000257-ampip7od	70	4	in	in	IN
cord-000257-ampip7od	70	5	GenBank	GenBank	NNP
cord-000257-ampip7od	70	6	and	and	CC
cord-000257-ampip7od	70	7	other	other	JJ
cord-000257-ampip7od	70	8	databases	database	NNS
cord-000257-ampip7od	70	9	now	now	RB
cord-000257-ampip7od	70	10	covers	cover	VBZ
cord-000257-ampip7od	70	11	over	over	IN
cord-000257-ampip7od	70	12	200.000	200.000	CD
cord-000257-ampip7od	70	13	species	specie	NNS
cord-000257-ampip7od	70	14	with	with	IN
cord-000257-ampip7od	70	15	at	at	RB
cord-000257-ampip7od	70	16	least	least	JJS
cord-000257-ampip7od	70	17	50	50	CD
cord-000257-ampip7od	70	18	complete	complete	JJ
cord-000257-ampip7od	70	19	genomes	genome	NNS
cord-000257-ampip7od	70	20	and	and	CC
cord-000257-ampip7od	70	21	this	this	DT
cord-000257-ampip7od	70	22	greatly	greatly	RB
cord-000257-ampip7od	70	23	facilitates	facilitate	VBZ
cord-000257-ampip7od	70	24	genome	genome	NN
cord-000257-ampip7od	70	25	comparisons	comparison	NNS
cord-000257-ampip7od	70	26	[	[	-LRB-
cord-000257-ampip7od	70	27	57	57	CD
cord-000257-ampip7od	70	28	]	]	-RRB-
cord-000257-ampip7od	70	29	[	[	-LRB-
cord-000257-ampip7od	70	30	58	58	CD
cord-000257-ampip7od	70	31	]	]	-RRB-
cord-000257-ampip7od	70	32	[	[	-LRB-
cord-000257-ampip7od	70	33	59	59	CD
cord-000257-ampip7od	70	34	]	]	-RRB-
cord-000257-ampip7od	70	35	.	.	.
cord-000257-ampip7od	71	1	Following	follow	VBG
cord-000257-ampip7od	71	2	such	such	JJ
cord-000257-ampip7od	71	3	extensive	extensive	JJ
cord-000257-ampip7od	71	4	comparisons	comparison	NNS
cord-000257-ampip7od	71	5	,	,	,
cord-000257-ampip7od	71	6	currently	currently	RB
cord-000257-ampip7od	71	7	>	>	XX
cord-000257-ampip7od	71	8	1700	1700	CD
cord-000257-ampip7od	71	9	domain	domain	NN
cord-000257-ampip7od	71	10	superfamilies	superfamily	NNS
cord-000257-ampip7od	71	11	are	be	VBP
cord-000257-ampip7od	71	12	recognized	recognize	VBN
cord-000257-ampip7od	71	13	in	in	IN
cord-000257-ampip7od	71	14	the	the	DT
cord-000257-ampip7od	71	15	recent	recent	JJ
cord-000257-ampip7od	71	16	release	release	NN
cord-000257-ampip7od	71	17	of	of	IN
cord-000257-ampip7od	71	18	the	the	DT
cord-000257-ampip7od	71	19	Structural	Structural	NNP
cord-000257-ampip7od	71	20	Classification	Classification	NNP
cord-000257-ampip7od	71	21	of	of	IN
cord-000257-ampip7od	71	22	Proteins	Proteins	NNP
cord-000257-ampip7od	71	23	(	(	-LRB-
cord-000257-ampip7od	71	24	SCOP	SCOP	NNP
cord-000257-ampip7od	71	25	)	)	-RRB-
cord-000257-ampip7od	72	1	[	[	-LRB-
cord-000257-ampip7od	72	2	60	60	CD
cord-000257-ampip7od	72	3	]	]	-RRB-
cord-000257-ampip7od	73	1	and	and	CC
cord-000257-ampip7od	73	2	it	-PRON-	PRP
cord-000257-ampip7od	73	3	has	have	VBZ
cord-000257-ampip7od	73	4	become	become	VBN
cord-000257-ampip7od	73	5	clear	clear	JJ
cord-000257-ampip7od	73	6	that	that	IN
cord-000257-ampip7od	73	7	many	many	JJ
cord-000257-ampip7od	73	8	proteins	protein	NNS
cord-000257-ampip7od	73	9	consist	consist	VBP
cord-000257-ampip7od	73	10	of	of	IN
cord-000257-ampip7od	73	11	more	more	JJR
cord-000257-ampip7od	73	12	than	than	IN
cord-000257-ampip7od	73	13	one	one	CD
cord-000257-ampip7od	73	14	domain	domain	NN
cord-000257-ampip7od	73	15	[	[	-LRB-
cord-000257-ampip7od	73	16	17	17	CD
cord-000257-ampip7od	73	17	,	,	,
cord-000257-ampip7od	73	18	61	61	CD
cord-000257-ampip7od	73	19	,	,	,
cord-000257-ampip7od	73	20	62	62	CD
cord-000257-ampip7od	73	21	]	]	-RRB-
cord-000257-ampip7od	73	22	.	.	.
cord-000257-ampip7od	74	1	Indeed	indeed	RB
cord-000257-ampip7od	74	2	,	,	,
cord-000257-ampip7od	74	3	it	-PRON-	PRP
cord-000257-ampip7od	74	4	has	have	VBZ
cord-000257-ampip7od	74	5	been	be	VBN
cord-000257-ampip7od	74	6	estimated	estimate	VBN
cord-000257-ampip7od	74	7	that	that	IN
cord-000257-ampip7od	74	8	at	at	RB
cord-000257-ampip7od	74	9	least	least	RBS
cord-000257-ampip7od	74	10	70	70	CD
cord-000257-ampip7od	74	11	%	%	NN
cord-000257-ampip7od	74	12	of	of	IN
cord-000257-ampip7od	74	13	the	the	DT
cord-000257-ampip7od	74	14	domains	domain	NNS
cord-000257-ampip7od	74	15	is	be	VBZ
cord-000257-ampip7od	74	16	duplicated	duplicate	VBN
cord-000257-ampip7od	74	17	in	in	IN
cord-000257-ampip7od	74	18	prokaryotes	prokaryote	NNS
cord-000257-ampip7od	74	19	,	,	,
cord-000257-ampip7od	74	20	whereas	whereas	IN
cord-000257-ampip7od	74	21	this	this	DT
cord-000257-ampip7od	74	22	number	number	NN
cord-000257-ampip7od	74	23	may	may	MD
cord-000257-ampip7od	74	24	even	even	RB
cord-000257-ampip7od	74	25	be	be	VB
cord-000257-ampip7od	74	26	higher	high	JJR
cord-000257-ampip7od	74	27	in	in	IN
cord-000257-ampip7od	74	28	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	74	29	,	,	,
cord-000257-ampip7od	74	30	likely	likely	RB
cord-000257-ampip7od	74	31	reaching	reach	VBG
cord-000257-ampip7od	74	32	up	up	IN
cord-000257-ampip7od	74	33	to	to	TO
cord-000257-ampip7od	74	34	90	90	CD
cord-000257-ampip7od	74	35	%	%	NN
cord-000257-ampip7od	74	36	[	[	-LRB-
cord-000257-ampip7od	74	37	35	35	CD
cord-000257-ampip7od	74	38	]	]	-RRB-
cord-000257-ampip7od	74	39	.	.	.
cord-000257-ampip7od	75	1	There	there	EX
cord-000257-ampip7od	75	2	are	be	VBP
cord-000257-ampip7od	75	3	various	various	JJ
cord-000257-ampip7od	75	4	mechanisms	mechanism	NNS
cord-000257-ampip7od	75	5	through	through	IN
cord-000257-ampip7od	75	6	which	which	WDT
cord-000257-ampip7od	75	7	protein	protein	NN
cord-000257-ampip7od	75	8	domain	domain	NN
cord-000257-ampip7od	75	9	or	or	CC
cord-000257-ampip7od	75	10	whole	whole	JJ
cord-000257-ampip7od	75	11	proteins	protein	NNS
cord-000257-ampip7od	75	12	may	may	MD
cord-000257-ampip7od	75	13	have	have	VB
cord-000257-ampip7od	75	14	been	be	VBN
cord-000257-ampip7od	75	15	duplicated	duplicate	VBN
cord-000257-ampip7od	75	16	.	.	.
cord-000257-ampip7od	76	1	On	on	IN
cord-000257-ampip7od	76	2	the	the	DT
cord-000257-ampip7od	76	3	largest	large	JJS
cord-000257-ampip7od	76	4	scale	scale	NN
cord-000257-ampip7od	76	5	,	,	,
cord-000257-ampip7od	76	6	whole	whole	JJ
cord-000257-ampip7od	76	7	genome	genome	NN
cord-000257-ampip7od	76	8	duplication	duplication	NN
cord-000257-ampip7od	76	9	such	such	JJ
cord-000257-ampip7od	76	10	as	as	IN
cord-000257-ampip7od	76	11	those	those	DT
cord-000257-ampip7od	76	12	seen	see	VBN
cord-000257-ampip7od	76	13	in	in	IN
cord-000257-ampip7od	76	14	the	the	DT
cord-000257-ampip7od	76	15	vertebrate	vertebrate	JJ
cord-000257-ampip7od	76	16	genomes	genome	NNS
cord-000257-ampip7od	76	17	duplicated	duplicate	VBD
cord-000257-ampip7od	76	18	whole	whole	JJ
cord-000257-ampip7od	76	19	gene	gene	NN
cord-000257-ampip7od	76	20	families	family	NNS
cord-000257-ampip7od	76	21	,	,	,
cord-000257-ampip7od	76	22	including	include	VBG
cord-000257-ampip7od	76	23	postsynaptic	postsynaptic	JJ
cord-000257-ampip7od	76	24	proteins	protein	NNS
cord-000257-ampip7od	76	25	,	,	,
cord-000257-ampip7od	76	26	hormone	hormone	NN
cord-000257-ampip7od	76	27	receptors	receptor	NNS
cord-000257-ampip7od	76	28	and	and	CC
cord-000257-ampip7od	76	29	muscle	muscle	NN
cord-000257-ampip7od	76	30	proteins	protein	NNS
cord-000257-ampip7od	76	31	,	,	,
cord-000257-ampip7od	76	32	and	and	CC
cord-000257-ampip7od	76	33	thereby	thereby	RB
cord-000257-ampip7od	76	34	dramatically	dramatically	RB
cord-000257-ampip7od	76	35	increased	increase	VBD
cord-000257-ampip7od	76	36	the	the	DT
cord-000257-ampip7od	76	37	domain	domain	NN
cord-000257-ampip7od	76	38	content	content	NN
cord-000257-ampip7od	76	39	and	and	CC
cord-000257-ampip7od	76	40	expanded	expand	VBN
cord-000257-ampip7od	76	41	networks	network	NNS
cord-000257-ampip7od	76	42	[	[	-LRB-
cord-000257-ampip7od	76	43	42	42	CD
cord-000257-ampip7od	76	44	,	,	,
cord-000257-ampip7od	76	45	63	63	CD
cord-000257-ampip7od	76	46	,	,	,
cord-000257-ampip7od	76	47	64	64	CD
cord-000257-ampip7od	76	48	]	]	-RRB-
cord-000257-ampip7od	76	49	.	.	.
cord-000257-ampip7od	77	1	On	on	IN
cord-000257-ampip7od	77	2	the	the	DT
cord-000257-ampip7od	77	3	other	other	JJ
cord-000257-ampip7od	77	4	end	end	NN
cord-000257-ampip7od	77	5	of	of	IN
cord-000257-ampip7od	77	6	the	the	DT
cord-000257-ampip7od	77	7	scale	scale	NN
cord-000257-ampip7od	77	8	,	,	,
cord-000257-ampip7od	77	9	domains	domain	NNS
cord-000257-ampip7od	77	10	and	and	CC
cord-000257-ampip7od	77	11	proteins	protein	NNS
cord-000257-ampip7od	77	12	have	have	VBP
cord-000257-ampip7od	77	13	been	be	VBN
cord-000257-ampip7od	77	14	duplicated	duplicate	VBN
cord-000257-ampip7od	77	15	through	through	IN
cord-000257-ampip7od	77	16	genetic	genetic	JJ
cord-000257-ampip7od	77	17	mechanisms	mechanism	NNS
cord-000257-ampip7od	77	18	like	like	IN
cord-000257-ampip7od	77	19	exon	exon	NN
cord-000257-ampip7od	77	20	-	-	HYPH
cord-000257-ampip7od	77	21	shuffling	shuffling	NN
cord-000257-ampip7od	77	22	,	,	,
cord-000257-ampip7od	77	23	retrotranspositions	retrotransposition	NNS
cord-000257-ampip7od	77	24	,	,	,
cord-000257-ampip7od	77	25	recombination	recombination	NN
cord-000257-ampip7od	77	26	and	and	CC
cord-000257-ampip7od	77	27	horizontal	horizontal	JJ
cord-000257-ampip7od	77	28	gene	gene	NN
cord-000257-ampip7od	77	29	transfer	transfer	NN
cord-000257-ampip7od	77	30	[	[	-LRB-
cord-000257-ampip7od	77	31	65	65	CD
cord-000257-ampip7od	77	32	]	]	-RRB-
cord-000257-ampip7od	77	33	[	[	-LRB-
cord-000257-ampip7od	77	34	66	66	CD
cord-000257-ampip7od	77	35	]	]	-RRB-
cord-000257-ampip7od	77	36	[	[	-LRB-
cord-000257-ampip7od	77	37	67	67	CD
cord-000257-ampip7od	77	38	]	]	-RRB-
cord-000257-ampip7od	77	39	.	.	.
cord-000257-ampip7od	78	1	Since	since	IN
cord-000257-ampip7od	78	2	the	the	DT
cord-000257-ampip7od	78	3	genetic	genetic	JJ
cord-000257-ampip7od	78	4	forces	force	NNS
cord-000257-ampip7od	78	5	,	,	,
cord-000257-ampip7od	78	6	like	like	IN
cord-000257-ampip7od	78	7	exon	exon	NN
cord-000257-ampip7od	78	8	-	-	HYPH
cord-000257-ampip7od	78	9	shuffling	shuffling	NN
cord-000257-ampip7od	78	10	and	and	CC
cord-000257-ampip7od	78	11	genome	genome	NN
cord-000257-ampip7od	78	12	duplication	duplication	NN
cord-000257-ampip7od	78	13	vary	vary	VBP
cord-000257-ampip7od	78	14	among	among	IN
cord-000257-ampip7od	78	15	species	specie	NNS
cord-000257-ampip7od	78	16	,	,	,
cord-000257-ampip7od	78	17	the	the	DT
cord-000257-ampip7od	78	18	total	total	JJ
cord-000257-ampip7od	78	19	number	number	NN
cord-000257-ampip7od	78	20	of	of	IN
cord-000257-ampip7od	78	21	domains	domain	NNS
cord-000257-ampip7od	78	22	and	and	CC
cord-000257-ampip7od	78	23	the	the	DT
cord-000257-ampip7od	78	24	types	type	NNS
cord-000257-ampip7od	78	25	of	of	IN
cord-000257-ampip7od	78	26	domains	domain	NNS
cord-000257-ampip7od	78	27	present	present	JJ
cord-000257-ampip7od	78	28	fluctuate	fluctuate	VBP
cord-000257-ampip7od	78	29	per	per	IN
cord-000257-ampip7od	78	30	genome	genome	NN
cord-000257-ampip7od	78	31	.	.	.
cord-000257-ampip7od	79	1	Interestingly	interestingly	RB
cord-000257-ampip7od	79	2	,	,	,
cord-000257-ampip7od	79	3	comparative	comparative	JJ
cord-000257-ampip7od	79	4	analyses	analysis	NNS
cord-000257-ampip7od	79	5	of	of	IN
cord-000257-ampip7od	79	6	genomes	genome	NNS
cord-000257-ampip7od	79	7	have	have	VBP
cord-000257-ampip7od	79	8	shown	show	VBN
cord-000257-ampip7od	79	9	that	that	IN
cord-000257-ampip7od	79	10	the	the	DT
cord-000257-ampip7od	79	11	number	number	NN
cord-000257-ampip7od	79	12	of	of	IN
cord-000257-ampip7od	79	13	unique	unique	JJ
cord-000257-ampip7od	79	14	domains	domain	NNS
cord-000257-ampip7od	79	15	encoded	encode	VBN
cord-000257-ampip7od	79	16	in	in	IN
cord-000257-ampip7od	79	17	organisms	organism	NNS
cord-000257-ampip7od	79	18	is	be	VBZ
cord-000257-ampip7od	79	19	generally	generally	RB
cord-000257-ampip7od	79	20	proportional	proportional	JJ
cord-000257-ampip7od	79	21	to	to	IN
cord-000257-ampip7od	79	22	its	-PRON-	PRP$
cord-000257-ampip7od	79	23	genome	genome	NN
cord-000257-ampip7od	79	24	size	size	NN
cord-000257-ampip7od	79	25	[	[	-LRB-
cord-000257-ampip7od	79	26	60	60	CD
cord-000257-ampip7od	79	27	,	,	,
cord-000257-ampip7od	79	28	68	68	CD
cord-000257-ampip7od	79	29	]	]	-RRB-
cord-000257-ampip7od	79	30	.	.	.
cord-000257-ampip7od	80	1	Within	within	IN
cord-000257-ampip7od	80	2	genomes	genome	NNS
cord-000257-ampip7od	80	3	,	,	,
cord-000257-ampip7od	80	4	the	the	DT
cord-000257-ampip7od	80	5	number	number	NN
cord-000257-ampip7od	80	6	of	of	IN
cord-000257-ampip7od	80	7	domains	domain	NNS
cord-000257-ampip7od	80	8	per	per	IN
cord-000257-ampip7od	80	9	gene	gene	NN
cord-000257-ampip7od	80	10	,	,	,
cord-000257-ampip7od	80	11	the	the	DT
cord-000257-ampip7od	80	12	socalled	socalled	JJ
cord-000257-ampip7od	80	13	modularity	modularity	NN
cord-000257-ampip7od	80	14	,	,	,
cord-000257-ampip7od	80	15	is	be	VBZ
cord-000257-ampip7od	80	16	related	relate	VBN
cord-000257-ampip7od	80	17	to	to	IN
cord-000257-ampip7od	80	18	genome	genome	NN
cord-000257-ampip7od	80	19	size	size	NN
cord-000257-ampip7od	80	20	via	via	IN
cord-000257-ampip7od	80	21	a	a	DT
cord-000257-ampip7od	80	22	power	power	NN
cord-000257-ampip7od	80	23	-	-	HYPH
cord-000257-ampip7od	80	24	law	law	NN
cord-000257-ampip7od	80	25	,	,	,
cord-000257-ampip7od	80	26	which	which	WDT
cord-000257-ampip7od	80	27	is	be	VBZ
cord-000257-ampip7od	80	28	essentially	essentially	RB
cord-000257-ampip7od	80	29	the	the	DT
cord-000257-ampip7od	80	30	relation	relation	NN
cord-000257-ampip7od	80	31	between	between	IN
cord-000257-ampip7od	80	32	the	the	DT
cord-000257-ampip7od	80	33	frequency	frequency	NN
cord-000257-ampip7od	80	34	f	f	NN
cord-000257-ampip7od	80	35	and	and	CC
cord-000257-ampip7od	80	36	an	an	DT
cord-000257-ampip7od	80	37	occurrence	occurrence	NN
cord-000257-ampip7od	80	38	x	x	:
cord-000257-ampip7od	80	39	raised	raise	VBN
cord-000257-ampip7od	80	40	by	by	IN
cord-000257-ampip7od	80	41	a	a	DT
cord-000257-ampip7od	80	42	scaling	scale	VBG
cord-000257-ampip7od	80	43	constant	constant	JJ
cord-000257-ampip7od	80	44	k	k	NN
cord-000257-ampip7od	80	45	(	(	-LRB-
cord-000257-ampip7od	80	46	i.e.	i.e.	FW
cord-000257-ampip7od	80	47	,	,	,
cord-000257-ampip7od	80	48	f	f	FW
cord-000257-ampip7od	80	49	(	(	-LRB-
cord-000257-ampip7od	80	50	x	x	NN
cord-000257-ampip7od	80	51	)	)	-RRB-
cord-000257-ampip7od	80	52	x	x	SYM
cord-000257-ampip7od	80	53	k	k	NNP
cord-000257-ampip7od	80	54	)	)	-RRB-
cord-000257-ampip7od	80	55	[	[	-LRB-
cord-000257-ampip7od	80	56	69	69	CD
cord-000257-ampip7od	80	57	,	,	,
cord-000257-ampip7od	80	58	70	70	CD
cord-000257-ampip7od	80	59	]	]	-RRB-
cord-000257-ampip7od	80	60	.	.	.
cord-000257-ampip7od	81	1	A	a	DT
cord-000257-ampip7od	81	2	similar	similar	JJ
cord-000257-ampip7od	81	3	correlation	correlation	NN
cord-000257-ampip7od	81	4	is	be	VBZ
cord-000257-ampip7od	81	5	found	find	VBN
cord-000257-ampip7od	81	6	when	when	WRB
cord-000257-ampip7od	81	7	the	the	DT
cord-000257-ampip7od	81	8	multi	multi	JJ
cord-000257-ampip7od	81	9	-	-	JJ
cord-000257-ampip7od	81	10	domain	domain	NN
cord-000257-ampip7od	81	11	architecture	architecture	NN
cord-000257-ampip7od	81	12	is	be	VBZ
cord-000257-ampip7od	81	13	compared	compare	VBN
cord-000257-ampip7od	81	14	to	to	IN
cord-000257-ampip7od	81	15	the	the	DT
cord-000257-ampip7od	81	16	number	number	NN
cord-000257-ampip7od	81	17	of	of	IN
cord-000257-ampip7od	81	18	cell	cell	NN
cord-000257-ampip7od	81	19	types	type	NNS
cord-000257-ampip7od	81	20	that	that	WDT
cord-000257-ampip7od	81	21	is	be	VBZ
cord-000257-ampip7od	81	22	present	present	JJ
cord-000257-ampip7od	81	23	in	in	IN
cord-000257-ampip7od	81	24	an	an	DT
cord-000257-ampip7od	81	25	organism	organism	NN
cord-000257-ampip7od	81	26	,	,	,
cord-000257-ampip7od	81	27	i.e.	i.e.	FW
cord-000257-ampip7od	81	28	,	,	,
cord-000257-ampip7od	81	29	the	the	DT
cord-000257-ampip7od	81	30	organism	organism	NN
cord-000257-ampip7od	81	31	complexity	complexity	NN
cord-000257-ampip7od	81	32	or	or	CC
cord-000257-ampip7od	81	33	when	when	WRB
cord-000257-ampip7od	81	34	the	the	DT
cord-000257-ampip7od	81	35	number	number	NN
cord-000257-ampip7od	81	36	of	of	IN
cord-000257-ampip7od	81	37	domains	domain	NNS
cord-000257-ampip7od	81	38	in	in	IN
cord-000257-ampip7od	81	39	a	a	DT
cord-000257-ampip7od	81	40	abundant	abundant	JJ
cord-000257-ampip7od	81	41	superfamily	superfamily	NN
cord-000257-ampip7od	81	42	is	be	VBZ
cord-000257-ampip7od	81	43	plotted	plot	VBN
cord-000257-ampip7od	81	44	against	against	IN
cord-000257-ampip7od	81	45	genome	genome	NN
cord-000257-ampip7od	81	46	size	size	NN
cord-000257-ampip7od	81	47	(	(	-LRB-
cord-000257-ampip7od	81	48	Fig	Fig	NNP
cord-000257-ampip7od	81	49	.	.	NNP
cord-000257-ampip7od	81	50	2	2	LS
cord-000257-ampip7od	81	51	)	)	-RRB-
cord-000257-ampip7od	81	52	[	[	-LRB-
cord-000257-ampip7od	81	53	71	71	CD
cord-000257-ampip7od	81	54	,	,	,
cord-000257-ampip7od	81	55	72	72	CD
cord-000257-ampip7od	81	56	]	]	-RRB-
cord-000257-ampip7od	81	57	.	.	.
cord-000257-ampip7od	82	1	Given	give	VBN
cord-000257-ampip7od	82	2	the	the	DT
cord-000257-ampip7od	82	3	amount	amount	NN
cord-000257-ampip7od	82	4	of	of	IN
cord-000257-ampip7od	82	5	domain	domain	NN
cord-000257-ampip7od	82	6	duplication	duplication	NN
cord-000257-ampip7od	82	7	and	and	CC
cord-000257-ampip7od	82	8	apparent	apparent	JJ
cord-000257-ampip7od	82	9	selection	selection	NN
cord-000257-ampip7od	82	10	for	for	IN
cord-000257-ampip7od	82	11	specific	specific	JJ
cord-000257-ampip7od	82	12	multi	multi	JJ
cord-000257-ampip7od	82	13	-	-	JJ
cord-000257-ampip7od	82	14	domain	domain	NN
cord-000257-ampip7od	82	15	encoding	encoding	NN
cord-000257-ampip7od	82	16	genes	gene	NNS
cord-000257-ampip7od	82	17	in	in	IN
cord-000257-ampip7od	82	18	,	,	,
cord-000257-ampip7od	82	19	for	for	IN
cord-000257-ampip7od	82	20	example	example	NN
cord-000257-ampip7od	82	21	,	,	,
cord-000257-ampip7od	82	22	vertebrates	vertebrate	NNS
cord-000257-ampip7od	82	23	,	,	,
cord-000257-ampip7od	82	24	it	-PRON-	PRP
cord-000257-ampip7od	82	25	may	may	MD
cord-000257-ampip7od	82	26	come	come	VB
cord-000257-ampip7od	82	27	as	as	RB
cord-000257-ampip7od	82	28	little	little	JJ
cord-000257-ampip7od	82	29	surprise	surprise	NN
cord-000257-ampip7od	82	30	that	that	IN
cord-000257-ampip7od	82	31	not	not	RB
cord-000257-ampip7od	82	32	all	all	DT
cord-000257-ampip7od	82	33	domains	domain	NNS
cord-000257-ampip7od	82	34	have	have	VBP
cord-000257-ampip7od	82	35	had	have	VBN
cord-000257-ampip7od	82	36	the	the	DT
cord-000257-ampip7od	82	37	same	same	JJ
cord-000257-ampip7od	82	38	tendency	tendency	NN
cord-000257-ampip7od	82	39	to	to	TO
cord-000257-ampip7od	82	40	recombine	recombine	VB
cord-000257-ampip7od	82	41	and	and	CC
cord-000257-ampip7od	82	42	distribute	distribute	VB
cord-000257-ampip7od	82	43	themselves	-PRON-	PRP
cord-000257-ampip7od	82	44	over	over	IN
cord-000257-ampip7od	82	45	the	the	DT
cord-000257-ampip7od	82	46	genomes	genome	NNS
cord-000257-ampip7od	82	47	[	[	-LRB-
cord-000257-ampip7od	82	48	68	68	CD
cord-000257-ampip7od	82	49	,	,	,
cord-000257-ampip7od	82	50	73	73	CD
cord-000257-ampip7od	82	51	]	]	-RRB-
cord-000257-ampip7od	82	52	.	.	.
cord-000257-ampip7od	83	1	In	in	IN
cord-000257-ampip7od	83	2	fact	fact	NN
cord-000257-ampip7od	83	3	,	,	,
cord-000257-ampip7od	83	4	some	some	DT
cord-000257-ampip7od	83	5	are	be	VBP
cord-000257-ampip7od	83	6	highly	highly	RB
cord-000257-ampip7od	83	7	abundant	abundant	JJ
cord-000257-ampip7od	83	8	and	and	CC
cord-000257-ampip7od	83	9	can	can	MD
cord-000257-ampip7od	83	10	be	be	VB
cord-000257-ampip7od	83	11	found	find	VBN
cord-000257-ampip7od	83	12	in	in	IN
cord-000257-ampip7od	83	13	many	many	JJ
cord-000257-ampip7od	83	14	different	different	JJ
cord-000257-ampip7od	83	15	multi	multi	JJ
cord-000257-ampip7od	83	16	-	-	JJ
cord-000257-ampip7od	83	17	domain	domain	JJ
cord-000257-ampip7od	83	18	architectures	architecture	NNS
cord-000257-ampip7od	83	19	,	,	,
cord-000257-ampip7od	83	20	whereas	whereas	IN
cord-000257-ampip7od	83	21	others	other	NNS
cord-000257-ampip7od	83	22	are	be	VBP
cord-000257-ampip7od	83	23	abundant	abundant	JJ
cord-000257-ampip7od	83	24	yet	yet	RB
cord-000257-ampip7od	83	25	confined	confine	VBN
cord-000257-ampip7od	83	26	to	to	IN
cord-000257-ampip7od	83	27	a	a	DT
cord-000257-ampip7od	83	28	small	small	JJ
cord-000257-ampip7od	83	29	sample	sample	NN
cord-000257-ampip7od	83	30	of	of	IN
cord-000257-ampip7od	83	31	architectures	architecture	NNS
cord-000257-ampip7od	83	32	or	or	CC
cord-000257-ampip7od	83	33	not	not	RB
cord-000257-ampip7od	83	34	abundant	abundant	JJ
cord-000257-ampip7od	83	35	at	at	RB
cord-000257-ampip7od	83	36	all	all	DT
cord-000257-ampip7od	83	37	[	[	-LRB-
cord-000257-ampip7od	83	38	68	68	CD
cord-000257-ampip7od	83	39	,	,	,
cord-000257-ampip7od	83	40	70	70	CD
cord-000257-ampip7od	83	41	]	]	-RRB-
cord-000257-ampip7od	83	42	.	.	.
cord-000257-ampip7od	84	1	Is	be	VBZ
cord-000257-ampip7od	84	2	there	there	EX
cord-000257-ampip7od	84	3	any	any	DT
cord-000257-ampip7od	84	4	significant	significant	JJ
cord-000257-ampip7od	84	5	correlation	correlation	NN
cord-000257-ampip7od	84	6	between	between	IN
cord-000257-ampip7od	84	7	the	the	DT
cord-000257-ampip7od	84	8	propensity	propensity	NN
cord-000257-ampip7od	84	9	to	to	TO
cord-000257-ampip7od	84	10	distribute	distribute	VB
cord-000257-ampip7od	84	11	and	and	CC
cord-000257-ampip7od	84	12	the	the	DT
cord-000257-ampip7od	84	13	functional	functional	JJ
cord-000257-ampip7od	84	14	roles	role	NNS
cord-000257-ampip7od	84	15	domains	domain	NNS
cord-000257-ampip7od	84	16	have	have	VBP
cord-000257-ampip7od	84	17	in	in	IN
cord-000257-ampip7od	84	18	cellular	cellular	JJ
cord-000257-ampip7od	84	19	pathways	pathway	NNS
cord-000257-ampip7od	84	20	?	?	.
cord-000257-ampip7od	85	1	Some	some	DT
cord-000257-ampip7od	85	2	of	of	IN
cord-000257-ampip7od	85	3	the	the	DT
cord-000257-ampip7od	85	4	most	most	RBS
cord-000257-ampip7od	85	5	abundant	abundant	JJ
cord-000257-ampip7od	85	6	domains	domain	NNS
cord-000257-ampip7od	85	7	can	can	MD
cord-000257-ampip7od	85	8	be	be	VB
cord-000257-ampip7od	85	9	found	find	VBN
cord-000257-ampip7od	85	10	in	in	IN
cord-000257-ampip7od	85	11	association	association	NN
cord-000257-ampip7od	85	12	with	with	IN
cord-000257-ampip7od	85	13	cellular	cellular	JJ
cord-000257-ampip7od	85	14	signaling	signal	VBG
cord-000257-ampip7od	85	15	cascades	cascade	NNS
cord-000257-ampip7od	85	16	and	and	CC
cord-000257-ampip7od	85	17	have	have	VBP
cord-000257-ampip7od	85	18	been	be	VBN
cord-000257-ampip7od	85	19	shown	show	VBN
cord-000257-ampip7od	85	20	to	to	TO
cord-000257-ampip7od	85	21	accumulate	accumulate	VB
cord-000257-ampip7od	85	22	non	non	JJ
cord-000257-ampip7od	85	23	-	-	JJ
cord-000257-ampip7od	85	24	linearly	linearly	RB
cord-000257-ampip7od	85	25	in	in	IN
cord-000257-ampip7od	85	26	relation	relation	NN
cord-000257-ampip7od	85	27	to	to	IN
cord-000257-ampip7od	85	28	the	the	DT
cord-000257-ampip7od	85	29	overall	overall	JJ
cord-000257-ampip7od	85	30	number	number	NN
cord-000257-ampip7od	85	31	of	of	IN
cord-000257-ampip7od	85	32	domains	domain	NNS
cord-000257-ampip7od	85	33	encoded	encode	VBN
cord-000257-ampip7od	85	34	or	or	CC
cord-000257-ampip7od	85	35	the	the	DT
cord-000257-ampip7od	85	36	genome	genome	NN
cord-000257-ampip7od	85	37	size	size	NN
cord-000257-ampip7od	85	38	[	[	-LRB-
cord-000257-ampip7od	85	39	70	70	CD
cord-000257-ampip7od	85	40	]	]	-RRB-
cord-000257-ampip7od	85	41	.	.	.
cord-000257-ampip7od	86	1	Additionally	additionally	RB
cord-000257-ampip7od	86	2	,	,	,
cord-000257-ampip7od	86	3	the	the	DT
cord-000257-ampip7od	86	4	on	on	IN
cord-000257-ampip7od	86	5	-	-	HYPH
cord-000257-ampip7od	86	6	set	set	NN
cord-000257-ampip7od	86	7	of	of	IN
cord-000257-ampip7od	86	8	the	the	DT
cord-000257-ampip7od	86	9	exponential	exponential	JJ
cord-000257-ampip7od	86	10	expansion	expansion	NN
cord-000257-ampip7od	86	11	of	of	IN
cord-000257-ampip7od	86	12	the	the	DT
cord-000257-ampip7od	86	13	number	number	NN
cord-000257-ampip7od	86	14	of	of	IN
cord-000257-ampip7od	86	15	abundant	abundant	JJ
cord-000257-ampip7od	86	16	and	and	CC
cord-000257-ampip7od	86	17	highly	highly	RB
cord-000257-ampip7od	86	18	recombining	recombine	VBG
cord-000257-ampip7od	86	19	domains	domain	NNS
cord-000257-ampip7od	86	20	has	have	VBZ
cord-000257-ampip7od	86	21	been	be	VBN
cord-000257-ampip7od	86	22	linked	link	VBN
cord-000257-ampip7od	86	23	to	to	IN
cord-000257-ampip7od	86	24	the	the	DT
cord-000257-ampip7od	86	25	appearance	appearance	NN
cord-000257-ampip7od	86	26	of	of	IN
cord-000257-ampip7od	86	27	multicellularity	multicellularity	NN
cord-000257-ampip7od	86	28	[	[	-LRB-
cord-000257-ampip7od	86	29	70	70	CD
cord-000257-ampip7od	86	30	]	]	-RRB-
cord-000257-ampip7od	86	31	.	.	.
cord-000257-ampip7od	87	1	A	a	DT
cord-000257-ampip7od	87	2	reoccurring	reoccurre	VBG
cord-000257-ampip7od	87	3	theme	theme	NN
cord-000257-ampip7od	87	4	among	among	IN
cord-000257-ampip7od	87	5	these	these	DT
cord-000257-ampip7od	87	6	abundant	abundant	JJ
cord-000257-ampip7od	87	7	domains	domain	NNS
cord-000257-ampip7od	87	8	is	be	VBZ
cord-000257-ampip7od	87	9	the	the	DT
cord-000257-ampip7od	87	10	function	function	NN
cord-000257-ampip7od	87	11	of	of	IN
cord-000257-ampip7od	87	12	protein	protein	NN
cord-000257-ampip7od	87	13	-	-	HYPH
cord-000257-ampip7od	87	14	protein	protein	NN
cord-000257-ampip7od	87	15	interaction	interaction	NN
cord-000257-ampip7od	87	16	and	and	CC
cord-000257-ampip7od	87	17	it	-PRON-	PRP
cord-000257-ampip7od	87	18	appears	appear	VBZ
cord-000257-ampip7od	87	19	that	that	IN
cord-000257-ampip7od	87	20	particularly	particularly	RB
cord-000257-ampip7od	87	21	these	these	DT
cord-000257-ampip7od	87	22	,	,	,
cord-000257-ampip7od	87	23	usually	usually	RB
cord-000257-ampip7od	87	24	globular	globular	JJ
cord-000257-ampip7od	87	25	domains	domain	NNS
cord-000257-ampip7od	87	26	,	,	,
cord-000257-ampip7od	87	27	have	have	VBP
cord-000257-ampip7od	87	28	been	be	VBN
cord-000257-ampip7od	87	29	particularly	particularly	RB
cord-000257-ampip7od	87	30	selected	select	VBN
cord-000257-ampip7od	87	31	for	for	IN
cord-000257-ampip7od	87	32	in	in	IN
cord-000257-ampip7od	87	33	more	more	JJR
cord-000257-ampip7od	87	34	complex	complex	JJ
cord-000257-ampip7od	87	35	organisms	organism	NNS
cord-000257-ampip7od	87	36	[	[	-LRB-
cord-000257-ampip7od	87	37	70	70	CD
cord-000257-ampip7od	87	38	]	]	-RRB-
cord-000257-ampip7od	87	39	.	.	.
cord-000257-ampip7od	88	1	This	this	DT
cord-000257-ampip7od	88	2	positive	positive	JJ
cord-000257-ampip7od	88	3	relation	relation	NN
cord-000257-ampip7od	88	4	is	be	VBZ
cord-000257-ampip7od	88	5	underlined	underline	VBN
cord-000257-ampip7od	88	6	by	by	IN
cord-000257-ampip7od	88	7	the	the	DT
cord-000257-ampip7od	88	8	association	association	NN
cord-000257-ampip7od	88	9	of	of	IN
cord-000257-ampip7od	88	10	these	these	DT
cord-000257-ampip7od	88	11	abundant	abundant	JJ
cord-000257-ampip7od	88	12	domains	domain	NNS
cord-000257-ampip7od	88	13	with	with	IN
cord-000257-ampip7od	88	14	disease	disease	NN
cord-000257-ampip7od	88	15	such	such	JJ
cord-000257-ampip7od	88	16	as	as	IN
cord-000257-ampip7od	88	17	cancer	cancer	NN
cord-000257-ampip7od	88	18	and	and	CC
cord-000257-ampip7od	88	19	gene	gene	NN
cord-000257-ampip7od	88	20	essentiality	essentiality	NN
cord-000257-ampip7od	88	21	as	as	IN
cord-000257-ampip7od	88	22	the	the	DT
cord-000257-ampip7od	88	23	highly	highly	RB
cord-000257-ampip7od	88	24	interacting	interact	VBG
cord-000257-ampip7od	88	25	proteins	protein	NNS
cord-000257-ampip7od	88	26	that	that	IN
cord-000257-ampip7od	88	27	they	-PRON-	PRP
cord-000257-ampip7od	88	28	are	be	VBP
cord-000257-ampip7od	88	29	part	part	NN
cord-000257-ampip7od	88	30	of	of	IN
cord-000257-ampip7od	88	31	have	have	VBP
cord-000257-ampip7od	88	32	central	central	JJ
cord-000257-ampip7od	88	33	places	place	NNS
cord-000257-ampip7od	88	34	in	in	IN
cord-000257-ampip7od	88	35	cascades	cascade	NNS
cord-000257-ampip7od	88	36	and	and	CC
cord-000257-ampip7od	88	37	need	need	VBP
cord-000257-ampip7od	88	38	to	to	TO
cord-000257-ampip7od	88	39	orchestrate	orchestrate	VB
cord-000257-ampip7od	88	40	a	a	DT
cord-000257-ampip7od	88	41	high	high	JJ
cord-000257-ampip7od	88	42	number	number	NN
cord-000257-ampip7od	88	43	of	of	IN
cord-000257-ampip7od	88	44	molecular	molecular	JJ
cord-000257-ampip7od	88	45	connections	connection	NNS
cord-000257-ampip7od	88	46	[	[	-LRB-
cord-000257-ampip7od	88	47	74	74	CD
cord-000257-ampip7od	88	48	,	,	,
cord-000257-ampip7od	88	49	75	75	CD
cord-000257-ampip7od	88	50	]	]	-RRB-
cord-000257-ampip7od	88	51	.	.	.
cord-000257-ampip7od	89	1	Their	-PRON-	PRP$
cord-000257-ampip7od	89	2	shape	shape	NN
cord-000257-ampip7od	89	3	and	and	CC
cord-000257-ampip7od	89	4	coding	code	VBG
cord-000257-ampip7od	89	5	regions	region	NNS
cord-000257-ampip7od	89	6	,	,	,
cord-000257-ampip7od	89	7	which	which	WDT
cord-000257-ampip7od	89	8	usually	usually	RB
cord-000257-ampip7od	89	9	lie	lie	VBP
cord-000257-ampip7od	89	10	within	within	IN
cord-000257-ampip7od	89	11	the	the	DT
cord-000257-ampip7od	89	12	boundaries	boundary	NNS
cord-000257-ampip7od	89	13	of	of	IN
cord-000257-ampip7od	89	14	one	one	CD
cord-000257-ampip7od	89	15	or	or	CC
cord-000257-ampip7od	89	16	two	two	CD
cord-000257-ampip7od	89	17	exons	exon	NNS
cord-000257-ampip7od	89	18	,	,	,
cord-000257-ampip7od	89	19	make	make	VB
cord-000257-ampip7od	89	20	them	-PRON-	PRP
cord-000257-ampip7od	89	21	ideally	ideally	RB
cord-000257-ampip7od	89	22	suited	suit	VBN
cord-000257-ampip7od	89	23	for	for	IN
cord-000257-ampip7od	89	24	such	such	PDT
cord-000257-ampip7od	89	25	a	a	DT
cord-000257-ampip7od	89	26	selection	selection	NN
cord-000257-ampip7od	89	27	,	,	,
cord-000257-ampip7od	89	28	since	since	IN
cord-000257-ampip7od	89	29	domains	domain	NNS
cord-000257-ampip7od	89	30	are	be	VBP
cord-000257-ampip7od	89	31	most	most	RBS
cord-000257-ampip7od	89	32	frequently	frequently	RB
cord-000257-ampip7od	89	33	gained	gain	VBN
cord-000257-ampip7od	89	34	through	through	IN
cord-000257-ampip7od	89	35	insertions	insertion	NNS
cord-000257-ampip7od	89	36	at	at	IN
cord-000257-ampip7od	89	37	the	the	DT
cord-000257-ampip7od	89	38	N	N	NNP
cord-000257-ampip7od	89	39	-	-	HYPH
cord-000257-ampip7od	89	40	or	or	CC
cord-000257-ampip7od	89	41	C	c	NN
cord-000257-ampip7od	89	42	-	-	HYPH
cord-000257-ampip7od	89	43	terminus	terminus	NN
cord-000257-ampip7od	89	44	and	and	CC
cord-000257-ampip7od	89	45	through	through	IN
cord-000257-ampip7od	89	46	exon	exon	NN
cord-000257-ampip7od	89	47	shuffling	shuffle	VBG
cord-000257-ampip7od	89	48	[	[	-LRB-
cord-000257-ampip7od	89	49	76	76	CD
cord-000257-ampip7od	89	50	]	]	-RRB-
cord-000257-ampip7od	89	51	[	[	-LRB-
cord-000257-ampip7od	89	52	77	77	CD
cord-000257-ampip7od	89	53	]	]	-RRB-
cord-000257-ampip7od	89	54	[	[	-LRB-
cord-000257-ampip7od	89	55	78	78	CD
cord-000257-ampip7od	89	56	]	]	-RRB-
cord-000257-ampip7od	89	57	.	.	.
cord-000257-ampip7od	90	1	From	from	IN
cord-000257-ampip7od	90	2	a	a	DT
cord-000257-ampip7od	90	3	mutational	mutational	JJ
cord-000257-ampip7od	90	4	point	point	NN
cord-000257-ampip7od	90	5	of	of	IN
cord-000257-ampip7od	90	6	view	view	NN
cord-000257-ampip7od	90	7	,	,	,
cord-000257-ampip7od	90	8	protein	protein	NN
cord-000257-ampip7od	90	9	-	-	HYPH
cord-000257-ampip7od	90	10	protein	protein	NN
cord-000257-ampip7od	90	11	interaction	interaction	NN
cord-000257-ampip7od	90	12	domains	domain	NNS
cord-000257-ampip7od	90	13	are	be	VBP
cord-000257-ampip7od	90	14	different	different	JJ
cord-000257-ampip7od	90	15	from	from	IN
cord-000257-ampip7od	90	16	other	other	JJ
cord-000257-ampip7od	90	17	domains	domain	NNS
cord-000257-ampip7od	90	18	as	as	RB
cord-000257-ampip7od	90	19	well	well	RB
cord-000257-ampip7od	90	20	and	and	CC
cord-000257-ampip7od	90	21	this	this	DT
cord-000257-ampip7od	90	22	appears	appear	VBZ
cord-000257-ampip7od	90	23	to	to	TO
cord-000257-ampip7od	90	24	be	be	VB
cord-000257-ampip7od	90	25	particularly	particularly	RB
cord-000257-ampip7od	90	26	true	true	JJ
cord-000257-ampip7od	90	27	for	for	IN
cord-000257-ampip7od	90	28	the	the	DT
cord-000257-ampip7od	90	29	group	group	NN
cord-000257-ampip7od	90	30	of	of	IN
cord-000257-ampip7od	90	31	small	small	JJ
cord-000257-ampip7od	90	32	,	,	,
cord-000257-ampip7od	90	33	relatively	relatively	RB
cord-000257-ampip7od	90	34	promiscuous	promiscuous	JJ
cord-000257-ampip7od	90	35	domains	domain	NNS
cord-000257-ampip7od	90	36	like	like	IN
cord-000257-ampip7od	90	37	SH3	SH3	NNP
cord-000257-ampip7od	90	38	and	and	CC
cord-000257-ampip7od	90	39	PDZ	PDZ	NNP
cord-000257-ampip7od	90	40	.	.	.
cord-000257-ampip7od	91	1	These	these	DT
cord-000257-ampip7od	91	2	domains	domain	NNS
cord-000257-ampip7od	91	3	are	be	VBP
cord-000257-ampip7od	91	4	promiscuous	promiscuous	JJ
cord-000257-ampip7od	91	5	in	in	IN
cord-000257-ampip7od	91	6	the	the	DT
cord-000257-ampip7od	91	7	sense	sense	NN
cord-000257-ampip7od	91	8	that	that	IN
cord-000257-ampip7od	91	9	they	-PRON-	PRP
cord-000257-ampip7od	91	10	both	both	DT
cord-000257-ampip7od	91	11	tend	tend	VBP
cord-000257-ampip7od	91	12	to	to	TO
cord-000257-ampip7od	91	13	physically	physically	RB
cord-000257-ampip7od	91	14	interact	interact	VB
cord-000257-ampip7od	91	15	with	with	IN
cord-000257-ampip7od	91	16	a	a	DT
cord-000257-ampip7od	91	17	large	large	JJ
cord-000257-ampip7od	91	18	number	number	NN
cord-000257-ampip7od	91	19	of	of	IN
cord-000257-ampip7od	91	20	ligands	ligand	NNS
cord-000257-ampip7od	91	21	[	[	-LRB-
cord-000257-ampip7od	91	22	79	79	CD
cord-000257-ampip7od	91	23	,	,	,
cord-000257-ampip7od	91	24	80	80	CD
cord-000257-ampip7od	91	25	]	]	-RRB-
cord-000257-ampip7od	91	26	and	and	CC
cord-000257-ampip7od	91	27	are	be	VBP
cord-000257-ampip7od	91	28	prone	prone	JJ
cord-000257-ampip7od	91	29	to	to	TO
cord-000257-ampip7od	91	30	move	move	VB
cord-000257-ampip7od	91	31	through	through	IN
cord-000257-ampip7od	91	32	the	the	DT
cord-000257-ampip7od	91	33	genome	genome	NN
cord-000257-ampip7od	91	34	to	to	TO
cord-000257-ampip7od	91	35	recombine	recombine	VB
cord-000257-ampip7od	91	36	with	with	IN
cord-000257-ampip7od	91	37	many	many	JJ
cord-000257-ampip7od	91	38	other	other	JJ
cord-000257-ampip7od	91	39	domains	domain	NNS
cord-000257-ampip7od	91	40	.	.	.
cord-000257-ampip7od	92	1	It	-PRON-	PRP
cord-000257-ampip7od	92	2	has	have	VBZ
cord-000257-ampip7od	92	3	been	be	VBN
cord-000257-ampip7od	92	4	found	find	VBN
cord-000257-ampip7od	92	5	that	that	IN
cord-000257-ampip7od	92	6	particularly	particularly	RB
cord-000257-ampip7od	92	7	these	these	DT
cord-000257-ampip7od	92	8	domains	domain	NNS
cord-000257-ampip7od	92	9	evolve	evolve	VBP
cord-000257-ampip7od	92	10	more	more	RBR
cord-000257-ampip7od	92	11	slowly	slowly	RB
cord-000257-ampip7od	92	12	than	than	IN
cord-000257-ampip7od	92	13	non	non	JJ
cord-000257-ampip7od	92	14	-	-	JJ
cord-000257-ampip7od	92	15	promiscuous	promiscuous	JJ
cord-000257-ampip7od	92	16	domains	domain	NNS
cord-000257-ampip7od	92	17	[	[	-LRB-
cord-000257-ampip7od	92	18	70	70	CD
cord-000257-ampip7od	92	19	]	]	-RRB-
cord-000257-ampip7od	92	20	.	.	.
cord-000257-ampip7od	93	1	This	this	DT
cord-000257-ampip7od	93	2	likely	likely	JJ
cord-000257-ampip7od	93	3	stems	stem	VBZ
cord-000257-ampip7od	93	4	from	from	IN
cord-000257-ampip7od	93	5	the	the	DT
cord-000257-ampip7od	93	6	fact	fact	NN
cord-000257-ampip7od	93	7	that	that	IN
cord-000257-ampip7od	93	8	they	-PRON-	PRP
cord-000257-ampip7od	93	9	are	be	VBP
cord-000257-ampip7od	93	10	required	require	VBN
cord-000257-ampip7od	93	11	to	to	TO
cord-000257-ampip7od	93	12	participate	participate	VB
cord-000257-ampip7od	93	13	in	in	IN
cord-000257-ampip7od	93	14	many	many	JJ
cord-000257-ampip7od	93	15	different	different	JJ
cord-000257-ampip7od	93	16	interactions	interaction	NNS
cord-000257-ampip7od	93	17	,	,	,
cord-000257-ampip7od	93	18	which	which	WDT
cord-000257-ampip7od	93	19	makes	make	VBZ
cord-000257-ampip7od	93	20	selection	selection	NN
cord-000257-ampip7od	93	21	pressures	pressure	NNS
cord-000257-ampip7od	93	22	more	more	RBR
cord-000257-ampip7od	93	23	stringent	stringent	JJ
cord-000257-ampip7od	93	24	and	and	CC
cord-000257-ampip7od	93	25	the	the	DT
cord-000257-ampip7od	93	26	appearance	appearance	NN
cord-000257-ampip7od	93	27	of	of	IN
cord-000257-ampip7od	93	28	the	the	DT
cord-000257-ampip7od	93	29	branches	branch	NNS
cord-000257-ampip7od	93	30	on	on	IN
cord-000257-ampip7od	93	31	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	93	32	trees	tree	NNS
cord-000257-ampip7od	93	33	relatively	relatively	RB
cord-000257-ampip7od	93	34	short	short	JJ
cord-000257-ampip7od	93	35	and	and	CC
cord-000257-ampip7od	93	36	more	more	RBR
cord-000257-ampip7od	93	37	difficult	difficult	JJ
cord-000257-ampip7od	93	38	to	to	TO
cord-000257-ampip7od	93	39	assess	assess	VB
cord-000257-ampip7od	93	40	when	when	WRB
cord-000257-ampip7od	93	41	co	co	JJ
cord-000257-ampip7od	93	42	-	-	JJ
cord-000257-ampip7od	93	43	evolutionary	evolutionary	JJ
cord-000257-ampip7od	93	44	data	datum	NNS
cord-000257-ampip7od	93	45	in	in	IN
cord-000257-ampip7od	93	46	terms	term	NNS
cord-000257-ampip7od	93	47	of	of	IN
cord-000257-ampip7od	93	48	other	other	JJ
cord-000257-ampip7od	93	49	domains	domain	NNS
cord-000257-ampip7od	93	50	in	in	IN
cord-000257-ampip7od	93	51	the	the	DT
cord-000257-ampip7od	93	52	same	same	JJ
cord-000257-ampip7od	93	53	gene	gene	NN
cord-000257-ampip7od	93	54	family	family	NN
cord-000257-ampip7od	93	55	or	or	CC
cord-000257-ampip7od	93	56	expression	expression	NN
cord-000257-ampip7od	93	57	patterns	pattern	NNS
cord-000257-ampip7od	93	58	is	be	VBZ
cord-000257-ampip7od	93	59	limited	limited	JJ
cord-000257-ampip7od	93	60	[	[	-LRB-
cord-000257-ampip7od	93	61	42	42	CD
cord-000257-ampip7od	93	62	,	,	,
cord-000257-ampip7od	93	63	63	63	CD
cord-000257-ampip7od	93	64	]	]	-RRB-
cord-000257-ampip7od	93	65	.	.	.
cord-000257-ampip7od	94	1	Non	non	JJ
cord-000257-ampip7od	94	2	-	-	JJ
cord-000257-ampip7od	94	3	promiscuous	promiscuous	JJ
cord-000257-ampip7od	94	4	domains	domain	NNS
cord-000257-ampip7od	94	5	on	on	IN
cord-000257-ampip7od	94	6	the	the	DT
cord-000257-ampip7od	94	7	other	other	JJ
cord-000257-ampip7od	94	8	hand	hand	NN
cord-000257-ampip7od	94	9	can	can	MD
cord-000257-ampip7od	94	10	quite	quite	RB
cord-000257-ampip7od	94	11	easily	easily	RB
cord-000257-ampip7od	94	12	evade	evade	VB
cord-000257-ampip7od	94	13	the	the	DT
cord-000257-ampip7od	94	14	selection	selection	NN
cord-000257-ampip7od	94	15	pressure	pressure	NN
cord-000257-ampip7od	94	16	by	by	IN
cord-000257-ampip7od	94	17	obtaining	obtain	VBG
cord-000257-ampip7od	94	18	compensatory	compensatory	JJ
cord-000257-ampip7od	94	19	mutations	mutation	NNS
cord-000257-ampip7od	94	20	either	either	CC
cord-000257-ampip7od	94	21	within	within	IN
cord-000257-ampip7od	94	22	themselves	-PRON-	PRP
cord-000257-ampip7od	94	23	or	or	CC
cord-000257-ampip7od	94	24	their	-PRON-	PRP$
cord-000257-ampip7od	94	25	specific	specific	JJ
cord-000257-ampip7od	94	26	binding	bind	VBG
cord-000257-ampip7od	94	27	partner	partner	NN
cord-000257-ampip7od	94	28	[	[	-LRB-
cord-000257-ampip7od	94	29	70	70	CD
cord-000257-ampip7od	94	30	]	]	-RRB-
cord-000257-ampip7od	94	31	.	.	.
cord-000257-ampip7od	95	1	The	the	DT
cord-000257-ampip7od	95	2	overall	overall	JJ
cord-000257-ampip7od	95	3	phenomenon	phenomenon	NN
cord-000257-ampip7od	95	4	that	that	IN
cord-000257-ampip7od	95	5	the	the	DT
cord-000257-ampip7od	95	6	number	number	NN
cord-000257-ampip7od	95	7	of	of	IN
cord-000257-ampip7od	95	8	protein	protein	NN
cord-000257-ampip7od	95	9	domains	domain	NNS
cord-000257-ampip7od	95	10	and	and	CC
cord-000257-ampip7od	95	11	their	-PRON-	PRP$
cord-000257-ampip7od	95	12	modularity	modularity	NN
cord-000257-ampip7od	95	13	increases	increase	NNS
cord-000257-ampip7od	95	14	as	as	IN
cord-000257-ampip7od	95	15	the	the	DT
cord-000257-ampip7od	95	16	genome	genome	NN
cord-000257-ampip7od	95	17	expands	expand	VBZ
cord-000257-ampip7od	95	18	has	have	VBZ
cord-000257-ampip7od	95	19	not	not	RB
cord-000257-ampip7od	95	20	been	be	VBN
cord-000257-ampip7od	95	21	linked	link	VBN
cord-000257-ampip7od	95	22	to	to	IN
cord-000257-ampip7od	95	23	a	a	DT
cord-000257-ampip7od	95	24	conclusive	conclusive	JJ
cord-000257-ampip7od	95	25	biological	biological	JJ
cord-000257-ampip7od	95	26	explanation	explanation	NN
cord-000257-ampip7od	95	27	yet	yet	RB
cord-000257-ampip7od	95	28	.	.	.
cord-000257-ampip7od	96	1	A	a	DT
cord-000257-ampip7od	96	2	rationale	rationale	NN
cord-000257-ampip7od	96	3	for	for	IN
cord-000257-ampip7od	96	4	the	the	DT
cord-000257-ampip7od	96	5	increase	increase	NN
cord-000257-ampip7od	96	6	in	in	IN
cord-000257-ampip7od	96	7	interactions	interaction	NNS
cord-000257-ampip7od	96	8	and	and	CC
cord-000257-ampip7od	96	9	functional	functional	JJ
cord-000257-ampip7od	96	10	subunits	subunit	NNS
cord-000257-ampip7od	96	11	,	,	,
cord-000257-ampip7od	96	12	however	however	RB
cord-000257-ampip7od	96	13	,	,	,
cord-000257-ampip7od	96	14	may	may	MD
cord-000257-ampip7od	96	15	derive	derive	VB
cord-000257-ampip7od	96	16	from	from	IN
cord-000257-ampip7od	96	17	the	the	DT
cord-000257-ampip7od	96	18	paradoxical	paradoxical	JJ
cord-000257-ampip7od	96	19	absence	absence	NN
cord-000257-ampip7od	96	20	of	of	IN
cord-000257-ampip7od	96	21	correlation	correlation	NN
cord-000257-ampip7od	96	22	between	between	IN
cord-000257-ampip7od	96	23	the	the	DT
cord-000257-ampip7od	96	24	number	number	NN
cord-000257-ampip7od	96	25	of	of	IN
cord-000257-ampip7od	96	26	genes	gene	NNS
cord-000257-ampip7od	96	27	encoded	encode	VBN
cord-000257-ampip7od	96	28	and	and	CC
cord-000257-ampip7od	96	29	organism	organism	NN
cord-000257-ampip7od	96	30	complexity	complexity	NN
cord-000257-ampip7od	96	31	,	,	,
cord-000257-ampip7od	96	32	the	the	DT
cord-000257-ampip7od	96	33	so	so	RB
cord-000257-ampip7od	96	34	-	-	HYPH
cord-000257-ampip7od	96	35	called	call	VBN
cord-000257-ampip7od	96	36	G	g	NN
cord-000257-ampip7od	96	37	-	-	HYPH
cord-000257-ampip7od	96	38	value	value	NN
cord-000257-ampip7od	96	39	paradox	paradox	NN
cord-000257-ampip7od	96	40	[	[	-LRB-
cord-000257-ampip7od	96	41	81	81	CD
cord-000257-ampip7od	96	42	]	]	-RRB-
cord-000257-ampip7od	96	43	.	.	.
cord-000257-ampip7od	97	1	There	there	EX
cord-000257-ampip7od	97	2	is	be	VBZ
cord-000257-ampip7od	97	3	indeed	indeed	RB
cord-000257-ampip7od	97	4	evidence	evidence	NN
cord-000257-ampip7od	97	5	that	that	IN
cord-000257-ampip7od	97	6	domains	domain	NNS
cord-000257-ampip7od	97	7	involved	involve	VBN
cord-000257-ampip7od	97	8	in	in	IN
cord-000257-ampip7od	97	9	the	the	DT
cord-000257-ampip7od	97	10	same	same	JJ
cord-000257-ampip7od	97	11	functional	functional	JJ
cord-000257-ampip7od	97	12	pathway	pathway	NN
cord-000257-ampip7od	97	13	tend	tend	VBP
cord-000257-ampip7od	97	14	to	to	TO
cord-000257-ampip7od	97	15	converge	converge	VB
cord-000257-ampip7od	97	16	in	in	IN
cord-000257-ampip7od	97	17	a	a	DT
cord-000257-ampip7od	97	18	single	single	JJ
cord-000257-ampip7od	97	19	protein	protein	NN
cord-000257-ampip7od	97	20	sequence	sequence	NN
cord-000257-ampip7od	97	21	,	,	,
cord-000257-ampip7od	97	22	which	which	WDT
cord-000257-ampip7od	97	23	would	would	MD
cord-000257-ampip7od	97	24	make	make	VB
cord-000257-ampip7od	97	25	pathways	pathway	NNS
cord-000257-ampip7od	97	26	more	more	RBR
cord-000257-ampip7od	97	27	controllable	controllable	JJ
cord-000257-ampip7od	97	28	and	and	CC
cord-000257-ampip7od	97	29	reliable	reliable	JJ
cord-000257-ampip7od	97	30	without	without	IN
cord-000257-ampip7od	97	31	the	the	DT
cord-000257-ampip7od	97	32	need	need	NN
cord-000257-ampip7od	97	33	for	for	IN
cord-000257-ampip7od	97	34	supplementary	supplementary	JJ
cord-000257-ampip7od	97	35	genes	gene	NNS
cord-000257-ampip7od	97	36	[	[	-LRB-
cord-000257-ampip7od	97	37	73	73	CD
cord-000257-ampip7od	97	38	]	]	-RRB-
cord-000257-ampip7od	97	39	.	.	.
cord-000257-ampip7od	98	1	Additionally	additionally	RB
cord-000257-ampip7od	98	2	,	,	,
cord-000257-ampip7od	98	3	the	the	DT
cord-000257-ampip7od	98	4	number	number	NN
cord-000257-ampip7od	98	5	of	of	IN
cord-000257-ampip7od	98	6	different	different	JJ
cord-000257-ampip7od	98	7	arrangements	arrangement	NNS
cord-000257-ampip7od	98	8	found	find	VBN
cord-000257-ampip7od	98	9	in	in	IN
cord-000257-ampip7od	98	10	higher	high	JJR
cord-000257-ampip7od	98	11	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	98	12	is	be	VBZ
cord-000257-ampip7od	98	13	,	,	,
cord-000257-ampip7od	98	14	given	give	VBN
cord-000257-ampip7od	98	15	the	the	DT
cord-000257-ampip7od	98	16	vast	vast	JJ
cord-000257-ampip7od	98	17	scale	scale	NN
cord-000257-ampip7od	98	18	of	of	IN
cord-000257-ampip7od	98	19	unique	unique	JJ
cord-000257-ampip7od	98	20	domains	domain	NNS
cord-000257-ampip7od	98	21	present	present	JJ
cord-000257-ampip7od	98	22	,	,	,
cord-000257-ampip7od	98	23	relatively	relatively	RB
cord-000257-ampip7od	98	24	limited	limited	JJ
cord-000257-ampip7od	98	25	.	.	.
cord-000257-ampip7od	99	1	This	this	DT
cord-000257-ampip7od	99	2	in	in	IN
cord-000257-ampip7od	99	3	turn	turn	NN
cord-000257-ampip7od	99	4	implies	imply	VBZ
cord-000257-ampip7od	99	5	that	that	IN
cord-000257-ampip7od	99	6	evolutionary	evolutionary	JJ
cord-000257-ampip7od	99	7	constraints	constraint	NNS
cord-000257-ampip7od	99	8	have	have	VBP
cord-000257-ampip7od	99	9	played	play	VBN
cord-000257-ampip7od	99	10	an	an	DT
cord-000257-ampip7od	99	11	important	important	JJ
cord-000257-ampip7od	99	12	role	role	NN
cord-000257-ampip7od	99	13	in	in	IN
cord-000257-ampip7od	99	14	selecting	select	VBG
cord-000257-ampip7od	99	15	the	the	DT
cord-000257-ampip7od	99	16	right	right	JJ
cord-000257-ampip7od	99	17	domain	domain	NN
cord-000257-ampip7od	99	18	combinations	combination	NNS
cord-000257-ampip7od	99	19	and	and	CC
cord-000257-ampip7od	99	20	the	the	DT
cord-000257-ampip7od	99	21	right	right	JJ
cord-000257-ampip7od	99	22	order	order	NN
cord-000257-ampip7od	99	23	from	from	IN
cord-000257-ampip7od	99	24	N	n	NN
cord-000257-ampip7od	99	25	-	-	HYPH
cord-000257-ampip7od	99	26	to	to	IN
cord-000257-ampip7od	99	27	C	c	NN
cord-000257-ampip7od	99	28	-	-	HYPH
cord-000257-ampip7od	99	29	terminus	terminus	NN
cord-000257-ampip7od	99	30	in	in	IN
cord-000257-ampip7od	99	31	multi	multi	JJ
cord-000257-ampip7od	99	32	-	-	JJ
cord-000257-ampip7od	99	33	domain	domain	NN
cord-000257-ampip7od	99	34	proteins	protein	NNS
cord-000257-ampip7od	99	35	[	[	-LRB-
cord-000257-ampip7od	99	36	13	13	CD
cord-000257-ampip7od	99	37	,	,	,
cord-000257-ampip7od	99	38	82	82	CD
cord-000257-ampip7od	99	39	]	]	-RRB-
cord-000257-ampip7od	99	40	.	.	.
cord-000257-ampip7od	100	1	In	in	IN
cord-000257-ampip7od	100	2	fact	fact	NN
cord-000257-ampip7od	100	3	,	,	,
cord-000257-ampip7od	100	4	the	the	DT
cord-000257-ampip7od	100	5	ordering	ordering	NN
cord-000257-ampip7od	100	6	and	and	CC
cord-000257-ampip7od	100	7	co	co	NN
cord-000257-ampip7od	100	8	-	-	NN
cord-000257-ampip7od	100	9	occurrence	occurrence	NN
cord-000257-ampip7od	100	10	of	of	IN
cord-000257-ampip7od	100	11	domains	domain	NNS
cord-000257-ampip7od	100	12	was	be	VBD
cord-000257-ampip7od	100	13	demonstrated	demonstrate	VBN
cord-000257-ampip7od	100	14	to	to	TO
cord-000257-ampip7od	100	15	hold	hold	VB
cord-000257-ampip7od	100	16	enough	enough	JJ
cord-000257-ampip7od	100	17	evolutionary	evolutionary	JJ
cord-000257-ampip7od	100	18	information	information	NN
cord-000257-ampip7od	100	19	to	to	TO
cord-000257-ampip7od	100	20	construct	construct	VB
cord-000257-ampip7od	100	21	a	a	DT
cord-000257-ampip7od	100	22	tree	tree	NN
cord-000257-ampip7od	100	23	of	of	IN
cord-000257-ampip7od	100	24	life	life	NN
cord-000257-ampip7od	100	25	similar	similar	JJ
cord-000257-ampip7od	100	26	to	to	IN
cord-000257-ampip7od	100	27	those	those	DT
cord-000257-ampip7od	100	28	based	base	VBN
cord-000257-ampip7od	100	29	on	on	IN
cord-000257-ampip7od	100	30	canonical	canonical	JJ
cord-000257-ampip7od	100	31	sequence	sequence	NN
cord-000257-ampip7od	100	32	data	datum	NNS
cord-000257-ampip7od	100	33	[	[	-LRB-
cord-000257-ampip7od	100	34	70	70	CD
cord-000257-ampip7od	100	35	]	]	-RRB-
cord-000257-ampip7od	100	36	.	.	.
cord-000257-ampip7od	101	1	Furthermore	furthermore	RB
cord-000257-ampip7od	101	2	,	,	,
cord-000257-ampip7od	101	3	the	the	DT
cord-000257-ampip7od	101	4	increased	increase	VBN
cord-000257-ampip7od	101	5	use	use	NN
cord-000257-ampip7od	101	6	of	of	IN
cord-000257-ampip7od	101	7	alternative	alternative	JJ
cord-000257-ampip7od	101	8	splicing	splicing	NN
cord-000257-ampip7od	101	9	and	and	CC
cord-000257-ampip7od	101	10	exon	exon	NN
cord-000257-ampip7od	101	11	skipping	skip	VBG
cord-000257-ampip7od	101	12	in	in	IN
cord-000257-ampip7od	101	13	higher	high	JJR
cord-000257-ampip7od	101	14	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	101	15	likely	likely	RB
cord-000257-ampip7od	101	16	supplied	supply	VBD
cord-000257-ampip7od	101	17	a	a	DT
cord-000257-ampip7od	101	18	novel	novel	JJ
cord-000257-ampip7od	101	19	way	way	NN
cord-000257-ampip7od	101	20	of	of	IN
cord-000257-ampip7od	101	21	proteome	proteome	NN
cord-000257-ampip7od	101	22	diversification	diversification	NN
cord-000257-ampip7od	101	23	by	by	IN
cord-000257-ampip7od	101	24	restricting	restrict	VBG
cord-000257-ampip7od	101	25	gene	gene	NN
cord-000257-ampip7od	101	26	duplication	duplication	NN
cord-000257-ampip7od	101	27	and	and	CC
cord-000257-ampip7od	101	28	stimulating	stimulate	VBG
cord-000257-ampip7od	101	29	the	the	DT
cord-000257-ampip7od	101	30	formation	formation	NN
cord-000257-ampip7od	101	31	of	of	IN
cord-000257-ampip7od	101	32	multi	multi	JJ
cord-000257-ampip7od	101	33	-	-	JJ
cord-000257-ampip7od	101	34	domain	domain	NN
cord-000257-ampip7od	101	35	proteins	protein	NNS
cord-000257-ampip7od	101	36	[	[	-LRB-
cord-000257-ampip7od	101	37	83	83	CD
cord-000257-ampip7od	101	38	,	,	,
cord-000257-ampip7od	101	39	84	84	CD
cord-000257-ampip7od	101	40	]	]	-RRB-
cord-000257-ampip7od	101	41	.	.	.
cord-000257-ampip7od	102	1	In	in	IN
cord-000257-ampip7od	102	2	plants	plant	NNS
cord-000257-ampip7od	102	3	,	,	,
cord-000257-ampip7od	102	4	however	however	RB
cord-000257-ampip7od	102	5	,	,	,
cord-000257-ampip7od	102	6	the	the	DT
cord-000257-ampip7od	102	7	latter	latter	JJ
cord-000257-ampip7od	102	8	notion	notion	NN
cord-000257-ampip7od	102	9	is	be	VBZ
cord-000257-ampip7od	102	10	not	not	RB
cord-000257-ampip7od	102	11	supported	support	VBN
cord-000257-ampip7od	102	12	since	since	IN
cord-000257-ampip7od	102	13	both	both	DT
cord-000257-ampip7od	102	14	mono	mono	NN
cord-000257-ampip7od	102	15	-	-	:
cord-000257-ampip7od	102	16	and	and	CC
cord-000257-ampip7od	102	17	dicots	dicot	NNS
cord-000257-ampip7od	102	18	show	show	VBP
cord-000257-ampip7od	102	19	limited	limited	JJ
cord-000257-ampip7od	102	20	alternative	alternative	NN
cord-000257-ampip7od	102	21	splicing	splicing	NN
cord-000257-ampip7od	102	22	and	and	CC
cord-000257-ampip7od	102	23	a	a	DT
cord-000257-ampip7od	102	24	more	more	RBR
cord-000257-ampip7od	102	25	extensive	extensive	JJ
cord-000257-ampip7od	102	26	polyploidy	polyploidy	NN
cord-000257-ampip7od	102	27	[	[	-LRB-
cord-000257-ampip7od	102	28	85	85	CD
cord-000257-ampip7od	102	29	]	]	-RRB-
cord-000257-ampip7od	102	30	[	[	-LRB-
cord-000257-ampip7od	102	31	86	86	CD
cord-000257-ampip7od	102	32	]	]	-RRB-
cord-000257-ampip7od	102	33	[	[	-LRB-
cord-000257-ampip7od	102	34	87	87	CD
cord-000257-ampip7od	102	35	]	]	-RRB-
cord-000257-ampip7od	102	36	.	.	.
cord-000257-ampip7od	103	1	It	-PRON-	PRP
cord-000257-ampip7od	103	2	is	be	VBZ
cord-000257-ampip7od	103	3	clear	clear	JJ
cord-000257-ampip7od	103	4	that	that	IN
cord-000257-ampip7od	103	5	some	some	DT
cord-000257-ampip7od	103	6	of	of	IN
cord-000257-ampip7od	103	7	the	the	DT
cord-000257-ampip7od	103	8	above	above	JJ
cord-000257-ampip7od	103	9	characteristics	characteristic	NNS
cord-000257-ampip7od	103	10	are	be	VBP
cord-000257-ampip7od	103	11	underappreciated	underappreciated	JJ
cord-000257-ampip7od	103	12	in	in	IN
cord-000257-ampip7od	103	13	the	the	DT
cord-000257-ampip7od	103	14	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	103	15	analysis	analysis	NN
cord-000257-ampip7od	103	16	of	of	IN
cord-000257-ampip7od	103	17	linear	linear	JJ
cord-000257-ampip7od	103	18	amino	amino	NN
cord-000257-ampip7od	103	19	acid	acid	NN
cord-000257-ampip7od	103	20	sequences	sequence	NNS
cord-000257-ampip7od	103	21	.	.	.
cord-000257-ampip7od	104	1	Moreover	moreover	RB
cord-000257-ampip7od	104	2	,	,	,
cord-000257-ampip7od	104	3	the	the	DT
cord-000257-ampip7od	104	4	effects	effect	NNS
cord-000257-ampip7od	104	5	of	of	IN
cord-000257-ampip7od	104	6	evolution	evolution	NN
cord-000257-ampip7od	104	7	extend	extend	VBP
cord-000257-ampip7od	104	8	even	even	RB
cord-000257-ampip7od	104	9	further	far	RBR
cord-000257-ampip7od	104	10	than	than	IN
cord-000257-ampip7od	104	11	these	these	DT
cord-000257-ampip7od	104	12	aspects	aspect	NNS
cord-000257-ampip7od	104	13	and	and	CC
cord-000257-ampip7od	104	14	entail	entail	VBP
cord-000257-ampip7od	104	15	transcriptional	transcriptional	JJ
cord-000257-ampip7od	104	16	and	and	CC
cord-000257-ampip7od	104	17	translational	translational	JJ
cord-000257-ampip7od	104	18	regulation	regulation	NN
cord-000257-ampip7od	104	19	,	,	,
cord-000257-ampip7od	104	20	intramolecular	intramolecular	JJ
cord-000257-ampip7od	104	21	domain	domain	NN
cord-000257-ampip7od	104	22	-	-	HYPH
cord-000257-ampip7od	104	23	domain	domain	NN
cord-000257-ampip7od	104	24	interactions	interaction	NNS
cord-000257-ampip7od	104	25	,	,	,
cord-000257-ampip7od	104	26	gene	gene	NN
cord-000257-ampip7od	104	27	modifications	modification	NNS
cord-000257-ampip7od	104	28	and	and	CC
cord-000257-ampip7od	104	29	post	post	JJ
cord-000257-ampip7od	104	30	-	-	JJ
cord-000257-ampip7od	104	31	translational	translational	JJ
cord-000257-ampip7od	104	32	protein	protein	NN
cord-000257-ampip7od	104	33	modifications	modification	NNS
cord-000257-ampip7od	104	34	[	[	-LRB-
cord-000257-ampip7od	104	35	88	88	CD
cord-000257-ampip7od	104	36	]	]	-RRB-
cord-000257-ampip7od	105	1	[	[	-LRB-
cord-000257-ampip7od	105	2	89	89	CD
cord-000257-ampip7od	105	3	]	]	-RRB-
cord-000257-ampip7od	106	1	[	[	-LRB-
cord-000257-ampip7od	106	2	90	90	CD
cord-000257-ampip7od	106	3	]	]	-RRB-
cord-000257-ampip7od	106	4	[	[	-LRB-
cord-000257-ampip7od	106	5	91	91	CD
cord-000257-ampip7od	106	6	]	]	-RRB-
cord-000257-ampip7od	106	7	[	[	-LRB-
cord-000257-ampip7od	106	8	92	92	CD
cord-000257-ampip7od	106	9	]	]	-RRB-
cord-000257-ampip7od	107	1	[	[	-LRB-
cord-000257-ampip7od	107	2	93	93	CD
cord-000257-ampip7od	107	3	]	]	-RRB-
cord-000257-ampip7od	108	1	[	[	-LRB-
cord-000257-ampip7od	108	2	94	94	CD
cord-000257-ampip7od	108	3	]	]	-RRB-
cord-000257-ampip7od	108	4	[	[	-LRB-
cord-000257-ampip7od	108	5	95	95	CD
cord-000257-ampip7od	108	6	]	]	-RRB-
cord-000257-ampip7od	109	1	[	[	-LRB-
cord-000257-ampip7od	109	2	96	96	CD
cord-000257-ampip7od	109	3	]	]	-RRB-
cord-000257-ampip7od	109	4	.	.	.
cord-000257-ampip7od	110	1	New	new	JJ
cord-000257-ampip7od	110	2	methods	method	NNS
cord-000257-ampip7od	110	3	are	be	VBP
cord-000257-ampip7od	110	4	thus	thus	RB
cord-000257-ampip7od	110	5	being	be	VBG
cord-000257-ampip7od	110	6	developed	develop	VBN
cord-000257-ampip7od	110	7	to	to	TO
cord-000257-ampip7od	110	8	take	take	VB
cord-000257-ampip7od	110	9	into	into	IN
cord-000257-ampip7od	110	10	account	account	NN
cord-000257-ampip7od	110	11	that	that	IN
cord-000257-ampip7od	110	12	when	when	WRB
cord-000257-ampip7od	110	13	sequences	sequence	NNS
cord-000257-ampip7od	110	14	evolve	evolve	VBP
cord-000257-ampip7od	110	15	,	,	,
cord-000257-ampip7od	110	16	their	-PRON-	PRP$
cord-000257-ampip7od	110	17	close	close	JJ
cord-000257-ampip7od	110	18	and	and	CC
cord-000257-ampip7od	110	19	distant	distant	JJ
cord-000257-ampip7od	110	20	functional	functional	JJ
cord-000257-ampip7od	110	21	relationships	relationship	NNS
cord-000257-ampip7od	110	22	evolve	evolve	VBP
cord-000257-ampip7od	110	23	in	in	IN
cord-000257-ampip7od	110	24	parallel	parallel	NN
cord-000257-ampip7od	110	25	.	.	.
cord-000257-ampip7od	111	1	Correlations	correlation	NNS
cord-000257-ampip7od	111	2	of	of	IN
cord-000257-ampip7od	111	3	mutations	mutation	NNS
cord-000257-ampip7od	111	4	have	have	VBP
cord-000257-ampip7od	111	5	already	already	RB
cord-000257-ampip7od	111	6	been	be	VBN
cord-000257-ampip7od	111	7	found	find	VBN
cord-000257-ampip7od	111	8	between	between	IN
cord-000257-ampip7od	111	9	residues	residue	NNS
cord-000257-ampip7od	111	10	of	of	IN
cord-000257-ampip7od	111	11	different	different	JJ
cord-000257-ampip7od	111	12	proteins	protein	NNS
cord-000257-ampip7od	111	13	[	[	-LRB-
cord-000257-ampip7od	111	14	97	97	CD
cord-000257-ampip7od	111	15	,	,	,
cord-000257-ampip7od	111	16	98	98	CD
cord-000257-ampip7od	111	17	]	]	-RRB-
cord-000257-ampip7od	111	18	and	and	CC
cord-000257-ampip7od	111	19	compensating	compensate	VBG
cord-000257-ampip7od	111	20	mutational	mutational	JJ
cord-000257-ampip7od	111	21	changes	change	NNS
cord-000257-ampip7od	111	22	at	at	IN
cord-000257-ampip7od	111	23	an	an	DT
cord-000257-ampip7od	111	24	interaction	interaction	NN
cord-000257-ampip7od	111	25	interface	interface	NN
cord-000257-ampip7od	111	26	were	be	VBD
cord-000257-ampip7od	111	27	shown	show	VBN
cord-000257-ampip7od	111	28	to	to	TO
cord-000257-ampip7od	111	29	recover	recover	VB
cord-000257-ampip7od	111	30	the	the	DT
cord-000257-ampip7od	111	31	instability	instability	NN
cord-000257-ampip7od	111	32	of	of	IN
cord-000257-ampip7od	111	33	a	a	DT
cord-000257-ampip7od	111	34	complex	complex	JJ
cord-000257-ampip7od	111	35	[	[	-LRB-
cord-000257-ampip7od	111	36	99	99	CD
cord-000257-ampip7od	111	37	]	]	-RRB-
cord-000257-ampip7od	111	38	.	.	.
cord-000257-ampip7od	112	1	These	these	DT
cord-000257-ampip7od	112	2	observations	observation	NNS
cord-000257-ampip7od	112	3	are	be	VBP
cord-000257-ampip7od	112	4	evidence	evidence	NN
cord-000257-ampip7od	112	5	for	for	IN
cord-000257-ampip7od	112	6	the	the	DT
cord-000257-ampip7od	112	7	current	current	JJ
cord-000257-ampip7od	112	8	evolutionary	evolutionary	JJ
cord-000257-ampip7od	112	9	models	model	NNS
cord-000257-ampip7od	112	10	for	for	IN
cord-000257-ampip7od	112	11	the	the	DT
cord-000257-ampip7od	112	12	protein	protein	NN
cord-000257-ampip7od	112	13	-	-	HYPH
cord-000257-ampip7od	112	14	protein	protein	NN
cord-000257-ampip7od	112	15	interaction	interaction	NN
cord-000257-ampip7od	112	16	(	(	-LRB-
cord-000257-ampip7od	112	17	PPIs	ppi	NNS
cord-000257-ampip7od	112	18	)	)	-RRB-
cord-000257-ampip7od	112	19	networks	network	NNS
cord-000257-ampip7od	112	20	that	that	WDT
cord-000257-ampip7od	112	21	are	be	VBP
cord-000257-ampip7od	112	22	being	be	VBG
cord-000257-ampip7od	112	23	constructed	construct	VBN
cord-000257-ampip7od	112	24	through	through	IN
cord-000257-ampip7od	112	25	large	large	JJ
cord-000257-ampip7od	112	26	-	-	HYPH
cord-000257-ampip7od	112	27	scale	scale	NN
cord-000257-ampip7od	112	28	screens	screen	NNS
cord-000257-ampip7od	112	29	[	[	-LRB-
cord-000257-ampip7od	112	30	100	100	CD
cord-000257-ampip7od	112	31	]	]	-RRB-
cord-000257-ampip7od	112	32	[	[	-LRB-
cord-000257-ampip7od	112	33	101	101	CD
cord-000257-ampip7od	112	34	]	]	-RRB-
cord-000257-ampip7od	112	35	[	[	-LRB-
cord-000257-ampip7od	112	36	102	102	CD
cord-000257-ampip7od	112	37	]	]	-RRB-
cord-000257-ampip7od	112	38	.	.	.
cord-000257-ampip7od	113	1	In	in	IN
cord-000257-ampip7od	113	2	these	these	DT
cord-000257-ampip7od	113	3	,	,	,
cord-000257-ampip7od	113	4	a	a	DT
cord-000257-ampip7od	113	5	gene	gene	NN
cord-000257-ampip7od	113	6	duplication	duplication	NN
cord-000257-ampip7od	113	7	or	or	CC
cord-000257-ampip7od	113	8	domain	domain	NN
cord-000257-ampip7od	113	9	duplication	duplication	NN
cord-000257-ampip7od	113	10	(	(	-LRB-
cord-000257-ampip7od	113	11	depending	depend	VBG
cord-000257-ampip7od	113	12	on	on	IN
cord-000257-ampip7od	113	13	the	the	DT
cord-000257-ampip7od	113	14	resolution	resolution	NN
cord-000257-ampip7od	113	15	of	of	IN
cord-000257-ampip7od	113	16	the	the	DT
cord-000257-ampip7od	113	17	network	network	NN
cord-000257-ampip7od	113	18	)	)	-RRB-
cord-000257-ampip7od	113	19	implies	imply	VBZ
cord-000257-ampip7od	113	20	the	the	DT
cord-000257-ampip7od	113	21	addition	addition	NN
cord-000257-ampip7od	113	22	of	of	IN
cord-000257-ampip7od	113	23	a	a	DT
cord-000257-ampip7od	113	24	node	node	NN
cord-000257-ampip7od	113	25	,	,	,
cord-000257-ampip7od	113	26	while	while	IN
cord-000257-ampip7od	113	27	the	the	DT
cord-000257-ampip7od	113	28	deletion	deletion	NN
cord-000257-ampip7od	113	29	of	of	IN
cord-000257-ampip7od	113	30	a	a	DT
cord-000257-ampip7od	113	31	gene	gene	NN
cord-000257-ampip7od	113	32	or	or	CC
cord-000257-ampip7od	113	33	domain	domain	NN
cord-000257-ampip7od	113	34	reduces	reduce	VBZ
cord-000257-ampip7od	113	35	the	the	DT
cord-000257-ampip7od	113	36	amount	amount	NN
cord-000257-ampip7od	113	37	of	of	IN
cord-000257-ampip7od	113	38	links	link	NNS
cord-000257-ampip7od	113	39	in	in	IN
cord-000257-ampip7od	113	40	the	the	DT
cord-000257-ampip7od	113	41	network	network	NN
cord-000257-ampip7od	114	1	(	(	-LRB-
cord-000257-ampip7od	114	2	Fig	Fig	NNP
cord-000257-ampip7od	114	3	.	.	.
cord-000257-ampip7od	114	4	3	3	CD
cord-000257-ampip7od	114	5	)	)	-RRB-
cord-000257-ampip7od	114	6	.	.	.
cord-000257-ampip7od	115	1	In	in	IN
cord-000257-ampip7od	115	2	the	the	DT
cord-000257-ampip7od	115	3	next	next	JJ
cord-000257-ampip7od	115	4	step	step	NN
cord-000257-ampip7od	115	5	,	,	,
cord-000257-ampip7od	115	6	extensive	extensive	JJ
cord-000257-ampip7od	115	7	network	network	NN
cord-000257-ampip7od	115	8	rewiring	rewiring	NN
cord-000257-ampip7od	115	9	may	may	MD
cord-000257-ampip7od	115	10	take	take	VB
cord-000257-ampip7od	115	11	place	place	NN
cord-000257-ampip7od	115	12	,	,	,
cord-000257-ampip7od	115	13	driven	drive	VBN
cord-000257-ampip7od	115	14	by	by	IN
cord-000257-ampip7od	115	15	the	the	DT
cord-000257-ampip7od	115	16	effect	effect	NN
cord-000257-ampip7od	115	17	of	of	IN
cord-000257-ampip7od	115	18	node	node	NN
cord-000257-ampip7od	115	19	addition	addition	NN
cord-000257-ampip7od	115	20	or	or	CC
cord-000257-ampip7od	115	21	node	node	NN
cord-000257-ampip7od	115	22	loss	loss	NN
cord-000257-ampip7od	115	23	in	in	IN
cord-000257-ampip7od	115	24	the	the	DT
cord-000257-ampip7od	115	25	network	network	NN
cord-000257-ampip7od	115	26	(	(	-LRB-
cord-000257-ampip7od	115	27	i.e.	i.e.	FW
cord-000257-ampip7od	115	28	,	,	,
cord-000257-ampip7od	115	29	the	the	DT
cord-000257-ampip7od	115	30	duplicability	duplicability	NN
cord-000257-ampip7od	115	31	or	or	CC
cord-000257-ampip7od	115	32	essentiality	essentiality	NN
cord-000257-ampip7od	115	33	of	of	IN
cord-000257-ampip7od	115	34	a	a	DT
cord-000257-ampip7od	115	35	domain	domain	NN
cord-000257-ampip7od	115	36	/	/	SYM
cord-000257-ampip7od	115	37	protein	protein	NN
cord-000257-ampip7od	115	38	)	)	-RRB-
cord-000257-ampip7od	115	39	and	and	CC
cord-000257-ampip7od	115	40	mutations	mutation	NNS
cord-000257-ampip7od	115	41	in	in	IN
cord-000257-ampip7od	115	42	the	the	DT
cord-000257-ampip7od	115	43	domain	domain	NN
cord-000257-ampip7od	115	44	-	-	HYPH
cord-000257-ampip7od	115	45	interaction	interaction	NN
cord-000257-ampip7od	115	46	interface	interface	NN
cord-000257-ampip7od	115	47	[	[	-LRB-
cord-000257-ampip7od	115	48	67	67	CD
cord-000257-ampip7od	115	49	,	,	,
cord-000257-ampip7od	115	50	74	74	CD
cord-000257-ampip7od	115	51	,	,	,
cord-000257-ampip7od	115	52	[	[	-LRB-
cord-000257-ampip7od	115	53	103	103	CD
cord-000257-ampip7od	115	54	]	]	-RRB-
cord-000257-ampip7od	115	55	[	[	-LRB-
cord-000257-ampip7od	115	56	104	104	CD
cord-000257-ampip7od	115	57	]	]	-RRB-
cord-000257-ampip7od	115	58	[	[	-LRB-
cord-000257-ampip7od	115	59	105	105	CD
cord-000257-ampip7od	115	60	]	]	-RRB-
cord-000257-ampip7od	115	61	.	.	.
cord-000257-ampip7od	116	1	Beyond	beyond	IN
cord-000257-ampip7od	116	2	mutations	mutation	NNS
cord-000257-ampip7od	116	3	at	at	IN
cord-000257-ampip7od	116	4	the	the	DT
cord-000257-ampip7od	116	5	domain	domain	NN
cord-000257-ampip7od	116	6	and	and	CC
cord-000257-ampip7od	116	7	protein	protein	NN
cord-000257-ampip7od	116	8	level	level	NN
cord-000257-ampip7od	116	9	,	,	,
cord-000257-ampip7od	116	10	regulation	regulation	NN
cord-000257-ampip7od	116	11	of	of	IN
cord-000257-ampip7od	116	12	protein	protein	NN
cord-000257-ampip7od	116	13	expression	expression	NN
cord-000257-ampip7od	116	14	provides	provide	VBZ
cord-000257-ampip7od	116	15	another	another	DT
cord-000257-ampip7od	116	16	vital	vital	JJ
cord-000257-ampip7od	116	17	mechanism	mechanism	NN
cord-000257-ampip7od	116	18	through	through	IN
cord-000257-ampip7od	116	19	which	which	WDT
cord-000257-ampip7od	116	20	protein	protein	NN
cord-000257-ampip7od	116	21	networks	network	NNS
cord-000257-ampip7od	116	22	can	can	MD
cord-000257-ampip7od	116	23	evolve	evolve	VB
cord-000257-ampip7od	116	24	.	.	.
cord-000257-ampip7od	117	1	Microarray	Microarray	NNP
cord-000257-ampip7od	117	2	studies	study	NNS
cord-000257-ampip7od	117	3	are	be	VBP
cord-000257-ampip7od	117	4	now	now	RB
cord-000257-ampip7od	117	5	well	well	RB
cord-000257-ampip7od	117	6	under	under	IN
cord-000257-ampip7od	117	7	way	way	NN
cord-000257-ampip7od	117	8	to	to	TO
cord-000257-ampip7od	117	9	map	map	VB
cord-000257-ampip7od	117	10	genome	genome	NN
cord-000257-ampip7od	117	11	-	-	HYPH
cord-000257-ampip7od	117	12	wide	wide	JJ
cord-000257-ampip7od	117	13	ex	ex	JJ
cord-000257-ampip7od	117	14	-	-	JJ
cord-000257-ampip7od	117	15	pression	pression	JJ
cord-000257-ampip7od	117	16	levels	level	NNS
cord-000257-ampip7od	117	17	of	of	IN
cord-000257-ampip7od	117	18	related	related	JJ
cord-000257-ampip7od	117	19	and	and	CC
cord-000257-ampip7od	117	20	non	non	JJ
cord-000257-ampip7od	117	21	-	-	JJ
cord-000257-ampip7od	117	22	related	related	JJ
cord-000257-ampip7od	117	23	genes	gene	NNS
cord-000257-ampip7od	117	24	under	under	IN
cord-000257-ampip7od	117	25	a	a	DT
cord-000257-ampip7od	117	26	variety	variety	NN
cord-000257-ampip7od	117	27	of	of	IN
cord-000257-ampip7od	117	28	conditions	condition	NNS
cord-000257-ampip7od	117	29	[	[	-LRB-
cord-000257-ampip7od	117	30	91	91	CD
cord-000257-ampip7od	117	31	,	,	,
cord-000257-ampip7od	117	32	[	[	-LRB-
cord-000257-ampip7od	117	33	94	94	CD
cord-000257-ampip7od	117	34	]	]	-RRB-
cord-000257-ampip7od	117	35	[	[	-LRB-
cord-000257-ampip7od	117	36	95	95	CD
cord-000257-ampip7od	117	37	]	]	-RRB-
cord-000257-ampip7od	117	38	[	[	-LRB-
cord-000257-ampip7od	117	39	96	96	CD
cord-000257-ampip7od	117	40	]	]	-RRB-
cord-000257-ampip7od	117	41	.	.	.
cord-000257-ampip7od	118	1	For	for	IN
cord-000257-ampip7od	118	2	example	example	NN
cord-000257-ampip7od	118	3	,	,	,
cord-000257-ampip7od	118	4	transcriptional	transcriptional	JJ
cord-000257-ampip7od	118	5	comparisons	comparison	NNS
cord-000257-ampip7od	118	6	have	have	VBP
cord-000257-ampip7od	118	7	investigated	investigate	VBN
cord-000257-ampip7od	118	8	aging	age	VBG
cord-000257-ampip7od	118	9	[	[	-LRB-
cord-000257-ampip7od	118	10	106	106	CD
cord-000257-ampip7od	118	11	]	]	-RRB-
cord-000257-ampip7od	118	12	and	and	CC
cord-000257-ampip7od	118	13	pathogenicity	pathogenicity	NN
cord-000257-ampip7od	118	14	[	[	-LRB-
cord-000257-ampip7od	118	15	107	107	CD
cord-000257-ampip7od	118	16	]	]	-RRB-
cord-000257-ampip7od	118	17	.	.	.
cord-000257-ampip7od	119	1	Unfortunately	unfortunately	RB
cord-000257-ampip7od	119	2	,	,	,
cord-000257-ampip7od	119	3	given	give	VBN
cord-000257-ampip7od	119	4	the	the	DT
cord-000257-ampip7od	119	5	highly	highly	RB
cord-000257-ampip7od	119	6	variable	variable	JJ
cord-000257-ampip7od	119	7	nature	nature	NN
cord-000257-ampip7od	119	8	of	of	IN
cord-000257-ampip7od	119	9	gene	gene	NN
cord-000257-ampip7od	119	10	expression	expression	NN
cord-000257-ampip7od	119	11	and	and	CC
cord-000257-ampip7od	119	12	the	the	DT
cord-000257-ampip7od	119	13	fact	fact	NN
cord-000257-ampip7od	119	14	that	that	IN
cord-000257-ampip7od	119	15	different	different	JJ
cord-000257-ampip7od	119	16	species	specie	NNS
cord-000257-ampip7od	119	17	may	may	MD
cord-000257-ampip7od	119	18	respond	respond	VB
cord-000257-ampip7od	119	19	different	different	JJ
cord-000257-ampip7od	119	20	to	to	IN
cord-000257-ampip7od	119	21	external	external	JJ
cord-000257-ampip7od	119	22	stimuli	stimulus	NNS
cord-000257-ampip7od	119	23	,	,	,
cord-000257-ampip7od	119	24	such	such	JJ
cord-000257-ampip7od	119	25	comparisons	comparison	NNS
cord-000257-ampip7od	119	26	can	can	MD
cord-000257-ampip7od	119	27	only	only	RB
cord-000257-ampip7od	119	28	be	be	VB
cord-000257-ampip7od	119	29	performed	perform	VBN
cord-000257-ampip7od	119	30	under	under	IN
cord-000257-ampip7od	119	31	strictly	strictly	RB
cord-000257-ampip7od	119	32	controlled	control	VBN
cord-000257-ampip7od	119	33	research	research	NN
cord-000257-ampip7od	119	34	conditions	condition	NNS
cord-000257-ampip7od	119	35	.	.	.
cord-000257-ampip7od	120	1	To	to	IN
cord-000257-ampip7od	120	2	date	date	NN
cord-000257-ampip7od	120	3	most	most	JJS
cord-000257-ampip7od	120	4	studies	study	NNS
cord-000257-ampip7od	120	5	have	have	VBP
cord-000257-ampip7od	120	6	therefore	therefore	RB
cord-000257-ampip7od	120	7	focused	focus	VBN
cord-000257-ampip7od	120	8	on	on	IN
cord-000257-ampip7od	120	9	the	the	DT
cord-000257-ampip7od	120	10	embryogenesis	embryogenesis	NN
cord-000257-ampip7od	120	11	,	,	,
cord-000257-ampip7od	120	12	metamorphosis	metamorphosis	NN
cord-000257-ampip7od	120	13	,	,	,
cord-000257-ampip7od	120	14	sex	sex	NN
cord-000257-ampip7od	120	15	-	-	HYPH
cord-000257-ampip7od	120	16	dependency	dependency	NN
cord-000257-ampip7od	120	17	and	and	CC
cord-000257-ampip7od	120	18	mutation	mutation	NN
cord-000257-ampip7od	120	19	rates	rate	NNS
cord-000257-ampip7od	120	20	of	of	IN
cord-000257-ampip7od	120	21	subspecies	subspecie	NNS
cord-000257-ampip7od	120	22	[	[	-LRB-
cord-000257-ampip7od	120	23	94	94	CD
cord-000257-ampip7od	120	24	,	,	,
cord-000257-ampip7od	120	25	[	[	-LRB-
cord-000257-ampip7od	120	26	108	108	CD
cord-000257-ampip7od	120	27	]	]	-RRB-
cord-000257-ampip7od	120	28	[	[	-LRB-
cord-000257-ampip7od	120	29	109	109	CD
cord-000257-ampip7od	120	30	]	]	-RRB-
cord-000257-ampip7od	120	31	[	[	-LRB-
cord-000257-ampip7od	120	32	110	110	CD
cord-000257-ampip7od	120	33	]	]	-RRB-
cord-000257-ampip7od	120	34	[	[	-LRB-
cord-000257-ampip7od	120	35	111	111	CD
cord-000257-ampip7od	120	36	]	]	-RRB-
cord-000257-ampip7od	120	37	.	.	.
cord-000257-ampip7od	121	1	Other	other	JJ
cord-000257-ampip7od	121	2	studies	study	NNS
cord-000257-ampip7od	121	3	have	have	VBP
cord-000257-ampip7od	121	4	revealed	reveal	VBN
cord-000257-ampip7od	121	5	valuable	valuable	JJ
cord-000257-ampip7od	121	6	information	information	NN
cord-000257-ampip7od	121	7	on	on	IN
cord-000257-ampip7od	121	8	promoter	promoter	NN
cord-000257-ampip7od	121	9	types	type	NNS
cord-000257-ampip7od	121	10	and	and	CC
cord-000257-ampip7od	121	11	duplication	duplication	NN
cord-000257-ampip7od	121	12	events	event	NNS
cord-000257-ampip7od	121	13	[	[	-LRB-
cord-000257-ampip7od	121	14	91	91	CD
cord-000257-ampip7od	121	15	]	]	-RRB-
cord-000257-ampip7od	121	16	[	[	-LRB-
cord-000257-ampip7od	121	17	92	92	CD
cord-000257-ampip7od	121	18	]	]	-RRB-
cord-000257-ampip7od	121	19	[	[	-LRB-
cord-000257-ampip7od	121	20	93	93	CD
cord-000257-ampip7od	121	21	]	]	-RRB-
cord-000257-ampip7od	121	22	[	[	-LRB-
cord-000257-ampip7od	121	23	94	94	CD
cord-000257-ampip7od	121	24	]	]	-RRB-
cord-000257-ampip7od	121	25	.	.	.
cord-000257-ampip7od	122	1	To	to	TO
cord-000257-ampip7od	122	2	overcome	overcome	VB
cord-000257-ampip7od	122	3	the	the	DT
cord-000257-ampip7od	122	4	limitations	limitation	NNS
cord-000257-ampip7od	122	5	mentioned	mention	VBN
cord-000257-ampip7od	122	6	in	in	IN
cord-000257-ampip7od	122	7	the	the	DT
cord-000257-ampip7od	122	8	previous	previous	JJ
cord-000257-ampip7od	122	9	paragraph	paragraph	NN
cord-000257-ampip7od	122	10	,	,	,
cord-000257-ampip7od	122	11	the	the	DT
cord-000257-ampip7od	122	12	analysis	analysis	NN
cord-000257-ampip7od	122	13	of	of	IN
cord-000257-ampip7od	122	14	co	co	JJ
cord-000257-ampip7od	122	15	-	-	JJ
cord-000257-ampip7od	122	16	expression	expression	JJ
cord-000257-ampip7od	122	17	data	datum	NNS
cord-000257-ampip7od	122	18	has	have	VBZ
cord-000257-ampip7od	122	19	been	be	VBN
cord-000257-ampip7od	122	20	developed	develop	VBN
cord-000257-ampip7od	122	21	to	to	TO
cord-000257-ampip7od	122	22	supplement	supplement	VB
cord-000257-ampip7od	122	23	the	the	DT
cord-000257-ampip7od	122	24	direct	direct	JJ
cord-000257-ampip7od	122	25	comparison	comparison	NN
cord-000257-ampip7od	122	26	of	of	IN
cord-000257-ampip7od	122	27	individual	individual	JJ
cord-000257-ampip7od	122	28	gene	gene	NN
cord-000257-ampip7od	122	29	expression	expression	NN
cord-000257-ampip7od	122	30	changes	change	VBZ
cord-000257-ampip7od	122	31	[	[	-LRB-
cord-000257-ampip7od	122	32	95	95	CD
cord-000257-ampip7od	122	33	]	]	-RRB-
cord-000257-ampip7od	122	34	.	.	.
cord-000257-ampip7od	123	1	In	in	IN
cord-000257-ampip7od	123	2	this	this	DT
cord-000257-ampip7od	123	3	procedure	procedure	NN
cord-000257-ampip7od	123	4	,	,	,
cord-000257-ampip7od	123	5	a	a	DT
cord-000257-ampip7od	123	6	coexpression	coexpression	NN
cord-000257-ampip7od	123	7	analysis	analysis	NN
cord-000257-ampip7od	123	8	of	of	IN
cord-000257-ampip7od	123	9	gene	gene	NN
cord-000257-ampip7od	123	10	pairs	pair	NNS
cord-000257-ampip7od	123	11	within	within	IN
cord-000257-ampip7od	123	12	each	each	DT
cord-000257-ampip7od	123	13	species	species	NN
cord-000257-ampip7od	123	14	precedes	precede	VBZ
cord-000257-ampip7od	123	15	the	the	DT
cord-000257-ampip7od	123	16	cross	cross	JJ
cord-000257-ampip7od	123	17	-	-	JJ
cord-000257-ampip7od	123	18	comparison	comparison	NN
cord-000257-ampip7od	123	19	of	of	IN
cord-000257-ampip7od	123	20	the	the	DT
cord-000257-ampip7od	123	21	different	different	JJ
cord-000257-ampip7od	123	22	organisms	organism	NNS
cord-000257-ampip7od	123	23	in	in	IN
cord-000257-ampip7od	123	24	the	the	DT
cord-000257-ampip7od	123	25	study	study	NN
cord-000257-ampip7od	123	26	.	.	.
cord-000257-ampip7od	124	1	This	this	DT
cord-000257-ampip7od	124	2	approach	approach	NN
cord-000257-ampip7od	124	3	thus	thus	RB
cord-000257-ampip7od	124	4	primarily	primarily	RB
cord-000257-ampip7od	124	5	focuses	focus	VBZ
cord-000257-ampip7od	124	6	on	on	IN
cord-000257-ampip7od	124	7	the	the	DT
cord-000257-ampip7od	124	8	similarity	similarity	NN
cord-000257-ampip7od	124	9	and	and	CC
cord-000257-ampip7od	124	10	differences	difference	NNS
cord-000257-ampip7od	124	11	of	of	IN
cord-000257-ampip7od	124	12	the	the	DT
cord-000257-ampip7od	124	13	orthologous	orthologous	JJ
cord-000257-ampip7od	124	14	genes	gene	NNS
cord-000257-ampip7od	124	15	within	within	IN
cord-000257-ampip7od	124	16	network	network	NN
cord-000257-ampip7od	124	17	,	,	,
cord-000257-ampip7od	124	18	and	and	CC
cord-000257-ampip7od	124	19	is	be	VBZ
cord-000257-ampip7od	124	20	therefore	therefore	RB
cord-000257-ampip7od	124	21	ideally	ideally	RB
cord-000257-ampip7od	124	22	suited	suit	VBN
cord-000257-ampip7od	124	23	for	for	IN
cord-000257-ampip7od	124	24	the	the	DT
cord-000257-ampip7od	124	25	study	study	NN
cord-000257-ampip7od	124	26	of	of	IN
cord-000257-ampip7od	124	27	protein	protein	NN
cord-000257-ampip7od	124	28	domain	domain	NN
cord-000257-ampip7od	124	29	evolution	evolution	NN
cord-000257-ampip7od	124	30	and	and	CC
cord-000257-ampip7od	124	31	has	have	VBZ
cord-000257-ampip7od	124	32	already	already	RB
cord-000257-ampip7od	124	33	revealed	reveal	VBN
cord-000257-ampip7od	124	34	that	that	IN
cord-000257-ampip7od	124	35	species	species	NN
cord-000257-ampip7od	124	36	-	-	HYPH
cord-000257-ampip7od	124	37	specific	specific	JJ
cord-000257-ampip7od	124	38	parts	part	NNS
cord-000257-ampip7od	124	39	Fig	fig	NN
cord-000257-ampip7od	124	40	.	.	.
cord-000257-ampip7od	125	1	(	(	-LRB-
cord-000257-ampip7od	125	2	3	3	CD
cord-000257-ampip7od	125	3	)	)	-RRB-
cord-000257-ampip7od	125	4	.	.	.
cord-000257-ampip7od	126	1	Evolutionary	evolutionary	JJ
cord-000257-ampip7od	126	2	models	model	NNS
cord-000257-ampip7od	126	3	for	for	IN
cord-000257-ampip7od	126	4	protein	protein	NN
cord-000257-ampip7od	126	5	-	-	HYPH
cord-000257-ampip7od	126	6	protein	protein	NN
cord-000257-ampip7od	126	7	interactions	interaction	NNS
cord-000257-ampip7od	126	8	.	.	.
cord-000257-ampip7od	127	1	The	the	DT
cord-000257-ampip7od	127	2	evolution	evolution	NN
cord-000257-ampip7od	127	3	of	of	IN
cord-000257-ampip7od	127	4	protein	protein	NN
cord-000257-ampip7od	127	5	networks	network	NNS
cord-000257-ampip7od	127	6	is	be	VBZ
cord-000257-ampip7od	127	7	tightly	tightly	RB
cord-000257-ampip7od	127	8	coupled	couple	VBN
cord-000257-ampip7od	127	9	to	to	IN
cord-000257-ampip7od	127	10	the	the	DT
cord-000257-ampip7od	127	11	addition	addition	NN
cord-000257-ampip7od	127	12	or	or	CC
cord-000257-ampip7od	127	13	deletion	deletion	NN
cord-000257-ampip7od	127	14	of	of	IN
cord-000257-ampip7od	127	15	nodes	node	NNS
cord-000257-ampip7od	127	16	.	.	.
cord-000257-ampip7od	128	1	Additionally	additionally	RB
cord-000257-ampip7od	128	2	,	,	,
cord-000257-ampip7od	128	3	events	event	NNS
cord-000257-ampip7od	128	4	that	that	WDT
cord-000257-ampip7od	128	5	introduce	introduce	VBP
cord-000257-ampip7od	128	6	mutations	mutation	NNS
cord-000257-ampip7od	128	7	in	in	IN
cord-000257-ampip7od	128	8	binding	bind	VBG
cord-000257-ampip7od	128	9	interfaces	interface	NNS
cord-000257-ampip7od	128	10	of	of	IN
cord-000257-ampip7od	128	11	proteins	protein	NNS
cord-000257-ampip7od	128	12	may	may	MD
cord-000257-ampip7od	128	13	result	result	VB
cord-000257-ampip7od	128	14	in	in	IN
cord-000257-ampip7od	128	15	the	the	DT
cord-000257-ampip7od	128	16	addition	addition	NN
cord-000257-ampip7od	128	17	or	or	CC
cord-000257-ampip7od	128	18	loss	loss	NN
cord-000257-ampip7od	128	19	of	of	IN
cord-000257-ampip7od	128	20	links	link	NNS
cord-000257-ampip7od	128	21	in	in	IN
cord-000257-ampip7od	128	22	the	the	DT
cord-000257-ampip7od	128	23	network	network	NN
cord-000257-ampip7od	128	24	.	.	.
cord-000257-ampip7od	129	1	Node	node	NN
cord-000257-ampip7od	129	2	addition	addition	NN
cord-000257-ampip7od	129	3	may	may	MD
cord-000257-ampip7od	129	4	take	take	VB
cord-000257-ampip7od	129	5	place	place	NN
cord-000257-ampip7od	129	6	through	through	IN
cord-000257-ampip7od	129	7	e.g.	e.g.	RB
cord-000257-ampip7od	129	8	,	,	,
cord-000257-ampip7od	129	9	domain	domain	NN
cord-000257-ampip7od	129	10	duplication	duplication	NN
cord-000257-ampip7od	129	11	or	or	CC
cord-000257-ampip7od	129	12	horizontal	horizontal	JJ
cord-000257-ampip7od	129	13	gene	gene	NN
cord-000257-ampip7od	129	14	transfer	transfer	NN
cord-000257-ampip7od	129	15	,	,	,
cord-000257-ampip7od	129	16	while	while	IN
cord-000257-ampip7od	129	17	rewiring	rewiring	NN
cord-000257-ampip7od	129	18	of	of	IN
cord-000257-ampip7od	129	19	the	the	DT
cord-000257-ampip7od	129	20	network	network	NN
cord-000257-ampip7od	129	21	is	be	VBZ
cord-000257-ampip7od	129	22	mediated	mediate	VBN
cord-000257-ampip7od	129	23	by	by	IN
cord-000257-ampip7od	129	24	point	point	NN
cord-000257-ampip7od	129	25	mutations	mutation	NNS
cord-000257-ampip7od	129	26	,	,	,
cord-000257-ampip7od	129	27	alternative	alternative	JJ
cord-000257-ampip7od	129	28	splice	splice	NN
cord-000257-ampip7od	129	29	variants	variant	NNS
cord-000257-ampip7od	129	30	and	and	CC
cord-000257-ampip7od	129	31	changes	change	NNS
cord-000257-ampip7od	129	32	in	in	IN
cord-000257-ampip7od	129	33	gene	gene	NN
cord-000257-ampip7od	129	34	expression	expression	NN
cord-000257-ampip7od	129	35	patterns	pattern	NNS
cord-000257-ampip7od	129	36	.	.	.
cord-000257-ampip7od	130	1	of	of	IN
cord-000257-ampip7od	130	2	an	an	DT
cord-000257-ampip7od	130	3	expression	expression	NN
cord-000257-ampip7od	130	4	network	network	NN
cord-000257-ampip7od	130	5	resulted	result	VBD
cord-000257-ampip7od	130	6	via	via	IN
cord-000257-ampip7od	130	7	a	a	DT
cord-000257-ampip7od	130	8	merge	merge	NN
cord-000257-ampip7od	130	9	of	of	IN
cord-000257-ampip7od	130	10	conserved	conserved	JJ
cord-000257-ampip7od	130	11	and	and	CC
cord-000257-ampip7od	130	12	newly	newly	RB
cord-000257-ampip7od	130	13	evolved	evolve	VBN
cord-000257-ampip7od	130	14	modules	module	NNS
cord-000257-ampip7od	130	15	[	[	-LRB-
cord-000257-ampip7od	130	16	95	95	CD
cord-000257-ampip7od	130	17	,	,	,
cord-000257-ampip7od	130	18	112	112	CD
cord-000257-ampip7od	130	19	,	,	,
cord-000257-ampip7od	130	20	113	113	CD
cord-000257-ampip7od	130	21	]	]	-RRB-
cord-000257-ampip7od	130	22	.	.	.
cord-000257-ampip7od	131	1	Finding	find	VBG
cord-000257-ampip7od	131	2	evolutionary	evolutionary	JJ
cord-000257-ampip7od	131	3	relationships	relationship	NNS
cord-000257-ampip7od	131	4	protein	protein	NN
cord-000257-ampip7od	131	5	domains	domain	NNS
cord-000257-ampip7od	131	6	is	be	VBZ
cord-000257-ampip7od	131	7	mostly	mostly	RB
cord-000257-ampip7od	131	8	based	base	VBN
cord-000257-ampip7od	131	9	on	on	IN
cord-000257-ampip7od	131	10	orthology	orthology	NN
cord-000257-ampip7od	131	11	and	and	CC
cord-000257-ampip7od	131	12	thus	thus	RB
cord-000257-ampip7od	131	13	commonly	commonly	RB
cord-000257-ampip7od	131	14	performed	perform	VBN
cord-000257-ampip7od	131	15	on	on	IN
cord-000257-ampip7od	131	16	best	good	JJS
cord-000257-ampip7od	131	17	sequence	sequence	NN
cord-000257-ampip7od	131	18	matches	match	NNS
cord-000257-ampip7od	131	19	.	.	.
cord-000257-ampip7od	132	1	Identifying	identify	VBG
cord-000257-ampip7od	132	2	these	these	DT
cord-000257-ampip7od	132	3	and	and	CC
cord-000257-ampip7od	132	4	categorizing	categorize	VBG
cord-000257-ampip7od	132	5	them	-PRON-	PRP
cord-000257-ampip7od	132	6	depends	depend	VBZ
cord-000257-ampip7od	132	7	largely	largely	RB
cord-000257-ampip7od	132	8	on	on	IN
cord-000257-ampip7od	132	9	multiple	multiple	JJ
cord-000257-ampip7od	132	10	sequence	sequence	NN
cord-000257-ampip7od	132	11	alignments	alignment	NNS
cord-000257-ampip7od	132	12	and	and	CC
cord-000257-ampip7od	132	13	this	this	DT
cord-000257-ampip7od	132	14	will	will	MD
cord-000257-ampip7od	132	15	in	in	IN
cord-000257-ampip7od	132	16	most	most	JJS
cord-000257-ampip7od	132	17	cases	case	NNS
cord-000257-ampip7od	132	18	give	give	VBP
cord-000257-ampip7od	132	19	good	good	JJ
cord-000257-ampip7od	132	20	indications	indication	NNS
cord-000257-ampip7od	132	21	for	for	IN
cord-000257-ampip7od	132	22	function	function	NN
cord-000257-ampip7od	132	23	,	,	,
cord-000257-ampip7od	132	24	fold	fold	VB
cord-000257-ampip7od	132	25	and	and	CC
cord-000257-ampip7od	132	26	ultimately	ultimately	RB
cord-000257-ampip7od	132	27	evolution	evolution	NN
cord-000257-ampip7od	132	28	.	.	.
cord-000257-ampip7od	133	1	However	however	RB
cord-000257-ampip7od	133	2	,	,	,
cord-000257-ampip7od	133	3	this	this	DT
cord-000257-ampip7od	133	4	approach	approach	NN
cord-000257-ampip7od	133	5	usually	usually	RB
cord-000257-ampip7od	133	6	discards	discard	VBZ
cord-000257-ampip7od	133	7	apparent	apparent	JJ
cord-000257-ampip7od	133	8	ambiguities	ambiguity	NNS
cord-000257-ampip7od	133	9	that	that	WDT
cord-000257-ampip7od	133	10	arise	arise	VBP
cord-000257-ampip7od	133	11	from	from	IN
cord-000257-ampip7od	133	12	speciesspecific	speciesspecific	NN
cord-000257-ampip7od	133	13	variations	variation	NNS
cord-000257-ampip7od	133	14	(	(	-LRB-
cord-000257-ampip7od	133	15	e.g.	e.g.	RB
cord-000257-ampip7od	133	16	,	,	,
cord-000257-ampip7od	133	17	due	due	IN
cord-000257-ampip7od	133	18	to	to	IN
cord-000257-ampip7od	133	19	population	population	NN
cord-000257-ampip7od	133	20	size	size	NN
cord-000257-ampip7od	133	21	,	,	,
cord-000257-ampip7od	133	22	metabolism	metabolism	NN
cord-000257-ampip7od	133	23	or	or	CC
cord-000257-ampip7od	133	24	species	species	NN
cord-000257-ampip7od	133	25	-	-	HYPH
cord-000257-ampip7od	133	26	specific	specific	JJ
cord-000257-ampip7od	133	27	domain	domain	NN
cord-000257-ampip7od	133	28	duplications	duplication	NNS
cord-000257-ampip7od	133	29	or	or	CC
cord-000257-ampip7od	133	30	losses	loss	NNS
cord-000257-ampip7od	133	31	)	)	-RRB-
cord-000257-ampip7od	133	32	and	and	CC
cord-000257-ampip7od	133	33	may	may	MD
cord-000257-ampip7od	133	34	therefore	therefore	RB
cord-000257-ampip7od	133	35	introduce	introduce	VB
cord-000257-ampip7od	133	36	significant	significant	JJ
cord-000257-ampip7od	133	37	biases	bias	NNS
cord-000257-ampip7od	133	38	[	[	-LRB-
cord-000257-ampip7od	133	39	114	114	CD
cord-000257-ampip7od	133	40	]	]	-RRB-
cord-000257-ampip7od	133	41	.	.	.
cord-000257-ampip7od	134	1	Biases	bias	NNS
cord-000257-ampip7od	134	2	may	may	MD
cord-000257-ampip7od	134	3	also	also	RB
cord-000257-ampip7od	134	4	derive	derive	VB
cord-000257-ampip7od	134	5	from	from	IN
cord-000257-ampip7od	134	6	the	the	DT
cord-000257-ampip7od	134	7	method	method	NN
cord-000257-ampip7od	134	8	of	of	IN
cord-000257-ampip7od	134	9	alignment	alignment	NN
cord-000257-ampip7od	134	10	,	,	,
cord-000257-ampip7od	134	11	the	the	DT
cord-000257-ampip7od	134	12	rate	rate	NN
cord-000257-ampip7od	134	13	variation	variation	NN
cord-000257-ampip7od	134	14	model	model	NN
cord-000257-ampip7od	134	15	used	use	VBN
cord-000257-ampip7od	134	16	to	to	TO
cord-000257-ampip7od	134	17	infer	infer	VB
cord-000257-ampip7od	134	18	the	the	DT
cord-000257-ampip7od	134	19	phylogeny	phylogeny	NN
cord-000257-ampip7od	134	20	,	,	,
cord-000257-ampip7od	134	21	and	and	CC
cord-000257-ampip7od	134	22	the	the	DT
cord-000257-ampip7od	134	23	sample	sample	NN
cord-000257-ampip7od	134	24	size	size	NN
cord-000257-ampip7od	134	25	used	use	VBN
cord-000257-ampip7od	134	26	to	to	TO
cord-000257-ampip7od	134	27	build	build	VB
cord-000257-ampip7od	134	28	the	the	DT
cord-000257-ampip7od	134	29	alignment	alignment	NN
cord-000257-ampip7od	134	30	[	[	-LRB-
cord-000257-ampip7od	134	31	39	39	CD
cord-000257-ampip7od	134	32	,	,	,
cord-000257-ampip7od	134	33	40	40	CD
cord-000257-ampip7od	134	34	,	,	,
cord-000257-ampip7od	134	35	115	115	CD
cord-000257-ampip7od	134	36	]	]	-RRB-
cord-000257-ampip7od	134	37	.	.	.
cord-000257-ampip7od	135	1	Care	care	NN
cord-000257-ampip7od	135	2	should	should	MD
cord-000257-ampip7od	135	3	therefore	therefore	RB
cord-000257-ampip7od	135	4	be	be	VB
cord-000257-ampip7od	135	5	taken	take	VBN
cord-000257-ampip7od	135	6	to	to	TO
cord-000257-ampip7od	135	7	not	not	RB
cord-000257-ampip7od	135	8	regard	regard	VB
cord-000257-ampip7od	135	9	orthology	orthology	NN
cord-000257-ampip7od	135	10	as	as	IN
cord-000257-ampip7od	135	11	a	a	DT
cord-000257-ampip7od	135	12	one	one	CD
cord-000257-ampip7od	135	13	-	-	HYPH
cord-000257-ampip7od	135	14	to	to	IN
cord-000257-ampip7od	135	15	-	-	HYPH
cord-000257-ampip7od	135	16	one	one	CD
cord-000257-ampip7od	135	17	relationship	relationship	NN
cord-000257-ampip7od	135	18	,	,	,
cord-000257-ampip7od	135	19	but	but	CC
cord-000257-ampip7od	135	20	as	as	IN
cord-000257-ampip7od	135	21	a	a	DT
cord-000257-ampip7od	135	22	family	family	NN
cord-000257-ampip7od	135	23	of	of	IN
cord-000257-ampip7od	135	24	homologous	homologous	JJ
cord-000257-ampip7od	135	25	relations	relation	NNS
cord-000257-ampip7od	135	26	[	[	-LRB-
cord-000257-ampip7od	135	27	91	91	CD
cord-000257-ampip7od	135	28	]	]	-RRB-
cord-000257-ampip7od	135	29	,	,	,
cord-000257-ampip7od	135	30	to	to	TO
cord-000257-ampip7od	135	31	select	select	VB
cord-000257-ampip7od	135	32	for	for	IN
cord-000257-ampip7od	135	33	appropriate	appropriate	JJ
cord-000257-ampip7od	135	34	analysis	analysis	NN
cord-000257-ampip7od	135	35	methods	method	NNS
cord-000257-ampip7od	135	36	[	[	-LRB-
cord-000257-ampip7od	135	37	39	39	CD
cord-000257-ampip7od	135	38	,	,	,
cord-000257-ampip7od	135	39	115	115	CD
cord-000257-ampip7od	135	40	]	]	-RRB-
cord-000257-ampip7od	135	41	and	and	CC
cord-000257-ampip7od	135	42	extend	extend	VB
cord-000257-ampip7od	135	43	comparative	comparative	JJ
cord-000257-ampip7od	135	44	data	datum	NNS
cord-000257-ampip7od	135	45	to	to	IN
cord-000257-ampip7od	135	46	protein	protein	NN
cord-000257-ampip7od	135	47	interactions	interaction	NNS
cord-000257-ampip7od	135	48	and	and	CC
cord-000257-ampip7od	135	49	expression	expression	NN
cord-000257-ampip7od	135	50	profiles	profile	NNS
cord-000257-ampip7od	135	51	[	[	-LRB-
cord-000257-ampip7od	135	52	91	91	CD
cord-000257-ampip7od	135	53	]	]	-RRB-
cord-000257-ampip7od	135	54	.	.	.
cord-000257-ampip7od	136	1	Indeed	indeed	RB
cord-000257-ampip7od	136	2	,	,	,
cord-000257-ampip7od	136	3	as	as	IN
cord-000257-ampip7od	136	4	our	-PRON-	PRP$
cord-000257-ampip7od	136	5	wealth	wealth	NN
cord-000257-ampip7od	136	6	of	of	IN
cord-000257-ampip7od	136	7	biological	biological	JJ
cord-000257-ampip7od	136	8	information	information	NN
cord-000257-ampip7od	136	9	expands	expand	VBZ
cord-000257-ampip7od	136	10	,	,	,
cord-000257-ampip7od	136	11	our	-PRON-	PRP$
cord-000257-ampip7od	136	12	systems	system	NNS
cord-000257-ampip7od	136	13	perspective	perspective	NN
cord-000257-ampip7od	136	14	will	will	MD
cord-000257-ampip7od	136	15	improve	improve	VB
cord-000257-ampip7od	136	16	and	and	CC
cord-000257-ampip7od	136	17	provide	provide	VB
cord-000257-ampip7od	136	18	us	-PRON-	PRP
cord-000257-ampip7od	136	19	with	with	IN
cord-000257-ampip7od	136	20	an	an	DT
cord-000257-ampip7od	136	21	opportunity	opportunity	NN
cord-000257-ampip7od	136	22	to	to	TO
cord-000257-ampip7od	136	23	reveal	reveal	VB
cord-000257-ampip7od	136	24	protein	protein	NN
cord-000257-ampip7od	136	25	domain	domain	NN
cord-000257-ampip7od	136	26	evolution	evolution	NN
cord-000257-ampip7od	136	27	at	at	IN
cord-000257-ampip7od	136	28	the	the	DT
cord-000257-ampip7od	136	29	level	level	NN
cord-000257-ampip7od	136	30	network	network	NN
cord-000257-ampip7od	136	31	organization	organization	NN
cord-000257-ampip7od	136	32	and	and	CC
cord-000257-ampip7od	136	33	dynamics	dynamic	NNS
cord-000257-ampip7od	136	34	.	.	.
cord-000257-ampip7od	137	1	Large	large	JJ
cord-000257-ampip7od	137	2	-	-	HYPH
cord-000257-ampip7od	137	3	scale	scale	NN
cord-000257-ampip7od	137	4	expression	expression	NN
cord-000257-ampip7od	137	5	studies	study	NNS
cord-000257-ampip7od	137	6	are	be	VBP
cord-000257-ampip7od	137	7	beginning	begin	VBG
cord-000257-ampip7od	137	8	to	to	TO
cord-000257-ampip7od	137	9	show	show	VB
cord-000257-ampip7od	137	10	us	-PRON-	PRP
cord-000257-ampip7od	137	11	evolutionary	evolutionary	JJ
cord-000257-ampip7od	137	12	correlations	correlation	NNS
cord-000257-ampip7od	137	13	between	between	IN
cord-000257-ampip7od	137	14	gene	gene	NN
cord-000257-ampip7od	137	15	expression	expression	NN
cord-000257-ampip7od	137	16	levels	level	NNS
cord-000257-ampip7od	137	17	and	and	CC
cord-000257-ampip7od	137	18	timings	timing	NNS
cord-000257-ampip7od	137	19	[	[	-LRB-
cord-000257-ampip7od	137	20	94	94	CD
cord-000257-ampip7od	137	21	,	,	,
cord-000257-ampip7od	137	22	106	106	CD
cord-000257-ampip7od	137	23	,	,	,
cord-000257-ampip7od	137	24	107	107	CD
cord-000257-ampip7od	137	25	,	,	,
cord-000257-ampip7od	137	26	112	112	CD
cord-000257-ampip7od	137	27	,	,	,
cord-000257-ampip7od	137	28	116	116	CD
cord-000257-ampip7od	137	29	]	]	-RRB-
cord-000257-ampip7od	137	30	,	,	,
cord-000257-ampip7od	137	31	while	while	IN
cord-000257-ampip7od	137	32	others	other	NNS
cord-000257-ampip7od	137	33	demonstrate	demonstrate	VBP
cord-000257-ampip7od	137	34	spatial	spatial	JJ
cord-000257-ampip7od	137	35	differences	difference	NNS
cord-000257-ampip7od	137	36	between	between	IN
cord-000257-ampip7od	137	37	paralogs	paralog	NNS
cord-000257-ampip7od	137	38	or	or	CC
cord-000257-ampip7od	137	39	(	(	-LRB-
cord-000257-ampip7od	137	40	partial	partial	JJ
cord-000257-ampip7od	137	41	)	)	-RRB-
cord-000257-ampip7od	137	42	overlap	overlap	VB
cord-000257-ampip7od	137	43	between	between	IN
cord-000257-ampip7od	137	44	interaction	interaction	NN
cord-000257-ampip7od	137	45	partners	partner	NNS
cord-000257-ampip7od	137	46	[	[	-LRB-
cord-000257-ampip7od	137	47	117	117	CD
cord-000257-ampip7od	137	48	]	]	-RRB-
cord-000257-ampip7od	137	49	[	[	-LRB-
cord-000257-ampip7od	137	50	118	118	CD
cord-000257-ampip7od	137	51	]	]	-RRB-
cord-000257-ampip7od	137	52	[	[	-LRB-
cord-000257-ampip7od	137	53	119	119	CD
cord-000257-ampip7od	137	54	]	]	-RRB-
cord-000257-ampip7od	137	55	[	[	-LRB-
cord-000257-ampip7od	137	56	120	120	CD
cord-000257-ampip7od	137	57	]	]	-RRB-
cord-000257-ampip7od	137	58	.	.	.
cord-000257-ampip7od	138	1	Indeed	indeed	RB
cord-000257-ampip7od	138	2	,	,	,
cord-000257-ampip7od	138	3	when	when	WRB
cord-000257-ampip7od	138	4	we	-PRON-	PRP
cord-000257-ampip7od	138	5	are	be	VBP
cord-000257-ampip7od	138	6	able	able	JJ
cord-000257-ampip7od	138	7	to	to	TO
cord-000257-ampip7od	138	8	map	map	VB
cord-000257-ampip7od	138	9	the	the	DT
cord-000257-ampip7od	138	10	spatiotemporal	spatiotemporal	JJ
cord-000257-ampip7od	138	11	aspects	aspect	NNS
cord-000257-ampip7od	138	12	of	of	IN
cord-000257-ampip7od	138	13	inter	inter	JJ
cord-000257-ampip7od	138	14	-	-	JJ
cord-000257-ampip7od	138	15	and	and	CC
cord-000257-ampip7od	138	16	intra	intra	JJ
cord-000257-ampip7od	138	17	-	-	JJ
cord-000257-ampip7od	138	18	molecular	molecular	JJ
cord-000257-ampip7od	138	19	interactions	interaction	NNS
cord-000257-ampip7od	138	20	we	-PRON-	PRP
cord-000257-ampip7od	138	21	will	will	MD
cord-000257-ampip7od	138	22	begin	begin	VB
cord-000257-ampip7od	138	23	to	to	TO
cord-000257-ampip7od	138	24	fully	fully	RB
cord-000257-ampip7od	138	25	understand	understand	VB
cord-000257-ampip7od	138	26	the	the	DT
cord-000257-ampip7od	138	27	versatile	versatile	JJ
cord-000257-ampip7od	138	28	power	power	NN
cord-000257-ampip7od	138	29	of	of	IN
cord-000257-ampip7od	138	30	evolution	evolution	NN
cord-000257-ampip7od	138	31	that	that	WDT
cord-000257-ampip7od	138	32	shaped	shape	VBD
cord-000257-ampip7od	138	33	the	the	DT
cord-000257-ampip7od	138	34	protein	protein	NN
cord-000257-ampip7od	138	35	universe	universe	NN
cord-000257-ampip7od	138	36	and	and	CC
cord-000257-ampip7od	138	37	life	life	NN
cord-000257-ampip7od	138	38	on	on	IN
cord-000257-ampip7od	138	39	Earth	Earth	NNP
cord-000257-ampip7od	138	40	[	[	-LRB-
cord-000257-ampip7od	138	41	118	118	CD
cord-000257-ampip7od	138	42	]	]	-RRB-
cord-000257-ampip7od	138	43	.	.	.
cord-000257-ampip7od	138	44	 	 	_SP
cord-000257-ampip7od	139	1	Phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	139	2	continuum	continuum	NN
cord-000257-ampip7od	139	3	indicates	indicate	VBZ
cord-000257-ampip7od	139	4	"	"	``
cord-000257-ampip7od	139	5	galaxies	galaxy	NNS
cord-000257-ampip7od	139	6	"	"	''
cord-000257-ampip7od	139	7	in	in	IN
cord-000257-ampip7od	139	8	the	the	DT
cord-000257-ampip7od	139	9	protein	protein	NN
cord-000257-ampip7od	139	10	universe	universe	NN
cord-000257-ampip7od	139	11	:	:	:
cord-000257-ampip7od	139	12	perliminary	perliminary	JJ
cord-000257-ampip7od	139	13	results	result	NNS
cord-000257-ampip7od	139	14	on	on	IN
cord-000257-ampip7od	139	15	the	the	DT
cord-000257-ampip7od	139	16	natural	natural	JJ
cord-000257-ampip7od	139	17	group	group	NN
cord-000257-ampip7od	139	18	structures	structure	NNS
cord-000257-ampip7od	139	19	of	of	IN
cord-000257-ampip7od	139	20	proteins	protein	NNS
cord-000257-ampip7od	140	1	The	the	DT
cord-000257-ampip7od	140	2	chemistry	chemistry	NN
cord-000257-ampip7od	140	3	of	of	IN
cord-000257-ampip7od	140	4	amino	amino	NN
cord-000257-ampip7od	140	5	acids	acid	NNS
cord-000257-ampip7od	140	6	and	and	CC
cord-000257-ampip7od	140	7	proteins	protein	NNS
cord-000257-ampip7od	140	8	Some	some	DT
cord-000257-ampip7od	140	9	peptides	peptide	NNS
cord-000257-ampip7od	140	10	from	from	IN
cord-000257-ampip7od	140	11	insulin	insulin	NN
cord-000257-ampip7od	140	12	Nucleotide	nucleotide	JJ
cord-000257-ampip7od	140	13	sequence	sequence	NN
cord-000257-ampip7od	140	14	from	from	IN
cord-000257-ampip7od	140	15	the	the	DT
cord-000257-ampip7od	140	16	coat	coat	NN
cord-000257-ampip7od	140	17	protein	protein	NN
cord-000257-ampip7od	140	18	cistron	cistron	NN
cord-000257-ampip7od	140	19	of	of	IN
cord-000257-ampip7od	140	20	R17	R17	NNP
cord-000257-ampip7od	140	21	bacteriophage	bacteriophage	NN
cord-000257-ampip7od	140	22	RNA	RNA	NNP
cord-000257-ampip7od	140	23	Use	Use	NNP
cord-000257-ampip7od	140	24	of	of	IN
cord-000257-ampip7od	140	25	DNA	dna	NN
cord-000257-ampip7od	140	26	polymerase	polymerase	NN
cord-000257-ampip7od	140	27	I	-PRON-	PRP
cord-000257-ampip7od	140	28	primed	prime	VBN
cord-000257-ampip7od	140	29	by	by	IN
cord-000257-ampip7od	140	30	a	a	DT
cord-000257-ampip7od	140	31	synthetic	synthetic	JJ
cord-000257-ampip7od	140	32	oligonucleotide	oligonucleotide	NN
cord-000257-ampip7od	140	33	to	to	TO
cord-000257-ampip7od	140	34	determine	determine	VB
cord-000257-ampip7od	140	35	a	a	DT
cord-000257-ampip7od	140	36	nucleotide	nucleotide	JJ
cord-000257-ampip7od	140	37	sequenc	sequenc	NN
cord-000257-ampip7od	140	38	of	of	IN
cord-000257-ampip7od	140	39	phage	phage	NN
cord-000257-ampip7od	140	40	fl	fl	NNP
cord-000257-ampip7od	140	41	DNA	DNA	NNP
cord-000257-ampip7od	140	42	DNA	dna	NN
cord-000257-ampip7od	140	43	sequencing	sequencing	NN
cord-000257-ampip7od	140	44	with	with	IN
cord-000257-ampip7od	140	45	chain	chain	NN
cord-000257-ampip7od	140	46	-	-	HYPH
cord-000257-ampip7od	140	47	terminating	terminate	VBG
cord-000257-ampip7od	140	48	inhibitors	inhibitor	NNS
cord-000257-ampip7od	141	1	The	the	DT
cord-000257-ampip7od	141	2	Genome	Genome	NNP
cord-000257-ampip7od	141	3	Sequence	sequence	NN
cord-000257-ampip7od	141	4	of	of	IN
cord-000257-ampip7od	141	5	Drosophila	Drosophila	NNP
cord-000257-ampip7od	141	6	melanogaster	melanogaster	NN
cord-000257-ampip7od	141	7	FlyBase	flybase	NN
cord-000257-ampip7od	141	8	:	:	:
cord-000257-ampip7od	141	9	genomes	genome	NNS
cord-000257-ampip7od	141	10	by	by	IN
cord-000257-ampip7od	141	11	the	the	DT
cord-000257-ampip7od	141	12	dozen	dozen	NN
cord-000257-ampip7od	141	13	Initial	initial	JJ
cord-000257-ampip7od	141	14	sequencing	sequencing	NN
cord-000257-ampip7od	141	15	and	and	CC
cord-000257-ampip7od	141	16	comparative	comparative	JJ
cord-000257-ampip7od	141	17	analysis	analysis	NN
cord-000257-ampip7od	141	18	of	of	IN
cord-000257-ampip7od	141	19	the	the	DT
cord-000257-ampip7od	141	20	mouse	mouse	NN
cord-000257-ampip7od	141	21	genome	genome	NN
cord-000257-ampip7od	141	22	Insights	insight	NNS
cord-000257-ampip7od	141	23	into	into	IN
cord-000257-ampip7od	141	24	social	social	JJ
cord-000257-ampip7od	141	25	insects	insect	NNS
cord-000257-ampip7od	141	26	from	from	IN
cord-000257-ampip7od	141	27	the	the	DT
cord-000257-ampip7od	141	28	genome	genome	NN
cord-000257-ampip7od	141	29	of	of	IN
cord-000257-ampip7od	141	30	the	the	DT
cord-000257-ampip7od	141	31	honeybee	honeybee	NN
cord-000257-ampip7od	141	32	Apis	Apis	NNP
cord-000257-ampip7od	141	33	mellifera	mellifera	NNP
cord-000257-ampip7od	141	34	Selectivity	selectivity	NN
cord-000257-ampip7od	141	35	and	and	CC
cord-000257-ampip7od	141	36	promiscuity	promiscuity	NN
cord-000257-ampip7od	141	37	in	in	IN
cord-000257-ampip7od	141	38	the	the	DT
cord-000257-ampip7od	141	39	interaction	interaction	NN
cord-000257-ampip7od	141	40	network	network	NN
cord-000257-ampip7od	141	41	mediated	mediate	VBN
cord-000257-ampip7od	141	42	by	by	IN
cord-000257-ampip7od	141	43	protein	protein	NN
cord-000257-ampip7od	141	44	recognition	recognition	NN
cord-000257-ampip7od	141	45	modules	module	NNS
cord-000257-ampip7od	141	46	Modular	Modular	NNP
cord-000257-ampip7od	141	47	peptide	peptide	NN
cord-000257-ampip7od	141	48	recognition	recognition	NN
cord-000257-ampip7od	141	49	domains	domain	NNS
cord-000257-ampip7od	141	50	in	in	IN
cord-000257-ampip7od	141	51	eukaryotic	eukaryotic	JJ
cord-000257-ampip7od	141	52	signaling	signal	VBG
cord-000257-ampip7od	141	53	The	the	DT
cord-000257-ampip7od	141	54	multiplicity	multiplicity	NN
cord-000257-ampip7od	141	55	of	of	IN
cord-000257-ampip7od	141	56	domains	domain	NNS
cord-000257-ampip7od	141	57	in	in	IN
cord-000257-ampip7od	141	58	proteins	protein	NNS
cord-000257-ampip7od	142	1	The	the	DT
cord-000257-ampip7od	142	2	modular	modular	JJ
cord-000257-ampip7od	142	3	nature	nature	NN
cord-000257-ampip7od	142	4	of	of	IN
cord-000257-ampip7od	142	5	apoptotic	apoptotic	JJ
cord-000257-ampip7od	142	6	signaling	signaling	NN
cord-000257-ampip7od	142	7	proteins	protein	NNS
cord-000257-ampip7od	143	1	Regulatory	regulatory	JJ
cord-000257-ampip7od	143	2	potential	potential	NN
cord-000257-ampip7od	143	3	,	,	,
cord-000257-ampip7od	143	4	phyletic	phyletic	JJ
cord-000257-ampip7od	143	5	distribution	distribution	NN
cord-000257-ampip7od	143	6	and	and	CC
cord-000257-ampip7od	143	7	evolution	evolution	NN
cord-000257-ampip7od	143	8	of	of	IN
cord-000257-ampip7od	143	9	ancient	ancient	JJ
cord-000257-ampip7od	143	10	,	,	,
cord-000257-ampip7od	143	11	intracellular	intracellular	JJ
cord-000257-ampip7od	143	12	smallmolecule	smallmolecule	NN
cord-000257-ampip7od	143	13	-	-	HYPH
cord-000257-ampip7od	143	14	binding	bind	VBG
cord-000257-ampip7od	143	15	domains	domain	NNS
cord-000257-ampip7od	143	16	Protein	Protein	NNP
cord-000257-ampip7od	143	17	families	family	NNS
cord-000257-ampip7od	143	18	and	and	CC
cord-000257-ampip7od	143	19	their	-PRON-	PRP$
cord-000257-ampip7od	143	20	evolution	evolution	NN
cord-000257-ampip7od	143	21	:	:	:
cord-000257-ampip7od	143	22	a	a	DT
cord-000257-ampip7od	143	23	structural	structural	JJ
cord-000257-ampip7od	143	24	perspective	perspective	NN
cord-000257-ampip7od	144	1	The	the	DT
cord-000257-ampip7od	144	2	folding	folding	NN
cord-000257-ampip7od	144	3	and	and	CC
cord-000257-ampip7od	144	4	evolution	evolution	NN
cord-000257-ampip7od	144	5	of	of	IN
cord-000257-ampip7od	144	6	multidomain	multidomain	NN
cord-000257-ampip7od	144	7	proteins	protein	NNS
cord-000257-ampip7od	145	1	The	the	DT
cord-000257-ampip7od	145	2	SUPERFAMILY	SUPERFAMILY	NNP
cord-000257-ampip7od	145	3	database	database	NN
cord-000257-ampip7od	145	4	in	in	IN
cord-000257-ampip7od	145	5	2007	2007	CD
cord-000257-ampip7od	145	6	:	:	:
cord-000257-ampip7od	145	7	families	family	NNS
cord-000257-ampip7od	145	8	and	and	CC
cord-000257-ampip7od	145	9	functions	function	NNS
cord-000257-ampip7od	146	1	SMART	smart	JJ
cord-000257-ampip7od	146	2	:	:	:
cord-000257-ampip7od	146	3	identification	identification	NN
cord-000257-ampip7od	146	4	and	and	CC
cord-000257-ampip7od	146	5	annotation	annotation	NN
cord-000257-ampip7od	146	6	of	of	IN
cord-000257-ampip7od	146	7	domains	domain	NNS
cord-000257-ampip7od	146	8	from	from	IN
cord-000257-ampip7od	146	9	signalling	signal	VBG
cord-000257-ampip7od	146	10	and	and	CC
cord-000257-ampip7od	146	11	extracellular	extracellular	JJ
cord-000257-ampip7od	146	12	protein	protein	NN
cord-000257-ampip7od	146	13	sequences	sequence	NNS
cord-000257-ampip7od	147	1	Comparative	comparative	JJ
cord-000257-ampip7od	147	2	genomics	genomic	NNS
cord-000257-ampip7od	147	3	:	:	:
cord-000257-ampip7od	147	4	genome	genome	NN
cord-000257-ampip7od	147	5	-	-	HYPH
cord-000257-ampip7od	147	6	wide	wide	JJ
cord-000257-ampip7od	147	7	analysis	analysis	NN
cord-000257-ampip7od	147	8	in	in	IN
cord-000257-ampip7od	147	9	metazoan	metazoan	NN
cord-000257-ampip7od	147	10	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	147	11	Distribution	distribution	NN
cord-000257-ampip7od	147	12	of	of	IN
cord-000257-ampip7od	147	13	indel	indel	NN
cord-000257-ampip7od	147	14	lengths	length	NNS
cord-000257-ampip7od	147	15	Heterogeneity	heterogeneity	NN
cord-000257-ampip7od	147	16	of	of	IN
cord-000257-ampip7od	147	17	nucleotide	nucleotide	JJ
cord-000257-ampip7od	147	18	frequencies	frequency	NNS
cord-000257-ampip7od	147	19	among	among	IN
cord-000257-ampip7od	147	20	evolutionary	evolutionary	JJ
cord-000257-ampip7od	147	21	lineages	lineage	NNS
cord-000257-ampip7od	147	22	and	and	CC
cord-000257-ampip7od	147	23	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	147	24	inference	inference	NN
cord-000257-ampip7od	147	25	Review	review	NN
cord-000257-ampip7od	147	26	of	of	IN
cord-000257-ampip7od	147	27	concepts	concept	NNS
cord-000257-ampip7od	147	28	,	,	,
cord-000257-ampip7od	147	29	case	case	NN
cord-000257-ampip7od	147	30	studies	study	NNS
cord-000257-ampip7od	147	31	and	and	CC
cord-000257-ampip7od	147	32	implications	implication	NNS
cord-000257-ampip7od	147	33	Who	who	WP
cord-000257-ampip7od	147	34	do	do	VBP
cord-000257-ampip7od	147	35	species	specie	NNS
cord-000257-ampip7od	147	36	vary	vary	VBP
cord-000257-ampip7od	147	37	in	in	IN
cord-000257-ampip7od	147	38	their	-PRON-	PRP$
cord-000257-ampip7od	147	39	rate	rate	NN
cord-000257-ampip7od	147	40	of	of	IN
cord-000257-ampip7od	147	41	molecular	molecular	JJ
cord-000257-ampip7od	147	42	evolution	evolution	NN
cord-000257-ampip7od	147	43	Infidelity	Infidelity	NNP
cord-000257-ampip7od	147	44	of	of	IN
cord-000257-ampip7od	147	45	SARS	SARS	NNP
cord-000257-ampip7od	147	46	-	-	HYPH
cord-000257-ampip7od	147	47	CoV	CoV	NNP
cord-000257-ampip7od	147	48	Nsp14-exonuclease	Nsp14-exonuclease	NNP
cord-000257-ampip7od	147	49	mutant	mutant	JJ
cord-000257-ampip7od	147	50	virus	virus	NN
cord-000257-ampip7od	147	51	replication	replication	NN
cord-000257-ampip7od	147	52	is	be	VBZ
cord-000257-ampip7od	147	53	revealed	reveal	VBN
cord-000257-ampip7od	147	54	by	by	IN
cord-000257-ampip7od	147	55	complete	complete	JJ
cord-000257-ampip7od	147	56	genome	genome	NN
cord-000257-ampip7od	147	57	sequencing	sequencing	NN
cord-000257-ampip7od	148	1	Who	who	WP
cord-000257-ampip7od	148	2	's	be	VBZ
cord-000257-ampip7od	148	3	your	-PRON-	PRP$
cord-000257-ampip7od	148	4	neighbor	neighbor	NN
cord-000257-ampip7od	148	5	?	?	.
cord-000257-ampip7od	149	1	New	new	JJ
cord-000257-ampip7od	149	2	computational	computational	JJ
cord-000257-ampip7od	149	3	approaches	approach	NNS
cord-000257-ampip7od	149	4	for	for	IN
cord-000257-ampip7od	149	5	functional	functional	JJ
cord-000257-ampip7od	149	6	genomics	genomic	NNS
cord-000257-ampip7od	149	7	Protein	Protein	NNP
cord-000257-ampip7od	149	8	function	function	NN
cord-000257-ampip7od	149	9	in	in	IN
cord-000257-ampip7od	149	10	the	the	DT
cord-000257-ampip7od	149	11	post	post	JJ
cord-000257-ampip7od	149	12	-	-	JJ
cord-000257-ampip7od	149	13	genomic	genomic	JJ
cord-000257-ampip7od	149	14	era	era	NN
cord-000257-ampip7od	150	1	The	the	DT
cord-000257-ampip7od	150	2	role	role	NN
cord-000257-ampip7od	150	3	of	of	IN
cord-000257-ampip7od	150	4	pattern	pattern	NN
cord-000257-ampip7od	150	5	databases	database	NNS
cord-000257-ampip7od	150	6	in	in	IN
cord-000257-ampip7od	150	7	sequence	sequence	NN
cord-000257-ampip7od	150	8	analysis	analysis	NN
cord-000257-ampip7od	150	9	Gene	Gene	NNP
cord-000257-ampip7od	150	10	Ontology	Ontology	NNP
cord-000257-ampip7od	150	11	:	:	:
cord-000257-ampip7od	150	12	tool	tool	NN
cord-000257-ampip7od	150	13	for	for	IN
cord-000257-ampip7od	150	14	the	the	DT
cord-000257-ampip7od	150	15	unification	unification	NN
cord-000257-ampip7od	150	16	of	of	IN
cord-000257-ampip7od	150	17	biology	biology	NN
cord-000257-ampip7od	150	18	Unique	Unique	NNP
cord-000257-ampip7od	150	19	and	and	CC
cord-000257-ampip7od	150	20	conserved	conserve	VBN
cord-000257-ampip7od	150	21	features	feature	NNS
cord-000257-ampip7od	150	22	of	of	IN
cord-000257-ampip7od	150	23	genome	genome	NN
cord-000257-ampip7od	150	24	and	and	CC
cord-000257-ampip7od	150	25	proteome	proteome	NN
cord-000257-ampip7od	150	26	of	of	IN
cord-000257-ampip7od	150	27	SARScoronavirus	SARScoronavirus	NNP
cord-000257-ampip7od	150	28	,	,	,
cord-000257-ampip7od	150	29	an	an	DT
cord-000257-ampip7od	150	30	early	early	JJ
cord-000257-ampip7od	150	31	split	split	NN
cord-000257-ampip7od	150	32	-	-	HYPH
cord-000257-ampip7od	150	33	off	off	NN
cord-000257-ampip7od	150	34	from	from	IN
cord-000257-ampip7od	150	35	the	the	DT
cord-000257-ampip7od	150	36	coronavirus	coronavirus	NN
cord-000257-ampip7od	150	37	group	group	NN
cord-000257-ampip7od	150	38	2	2	CD
cord-000257-ampip7od	150	39	lineage	lineage	NN
cord-000257-ampip7od	150	40	PHYLIP	PHYLIP	NNP
cord-000257-ampip7od	150	41	version	version	NN
cord-000257-ampip7od	150	42	3.63	3.63	CD
cord-000257-ampip7od	150	43	.	.	.
cord-000257-ampip7od	151	1	Deptartment	Deptartment	NNP
cord-000257-ampip7od	151	2	of	of	IN
cord-000257-ampip7od	151	3	Genetics	Genetics	NNP
cord-000257-ampip7od	151	4	Gapped	gap	VBD
cord-000257-ampip7od	151	5	BLAST	blast	NN
cord-000257-ampip7od	151	6	and	and	CC
cord-000257-ampip7od	151	7	PSI	psi	NN
cord-000257-ampip7od	151	8	-	-	HYPH
cord-000257-ampip7od	151	9	BLAST	blast	NN
cord-000257-ampip7od	151	10	:	:	:
cord-000257-ampip7od	151	11	a	a	DT
cord-000257-ampip7od	151	12	new	new	JJ
cord-000257-ampip7od	151	13	generation	generation	NN
cord-000257-ampip7od	151	14	of	of	IN
cord-000257-ampip7od	151	15	protein	protein	NN
cord-000257-ampip7od	151	16	database	database	NN
cord-000257-ampip7od	151	17	search	search	NN
cord-000257-ampip7od	151	18	programs	program	NNS
cord-000257-ampip7od	152	1	The	the	DT
cord-000257-ampip7od	152	2	CLUSTAL_X	clustal_x	NN
cord-000257-ampip7od	152	3	windows	windows	NNP
cord-000257-ampip7od	152	4	interface	interface	NN
cord-000257-ampip7od	152	5	:	:	:
cord-000257-ampip7od	152	6	flexible	flexible	JJ
cord-000257-ampip7od	152	7	strategies	strategy	NNS
cord-000257-ampip7od	152	8	for	for	IN
cord-000257-ampip7od	152	9	multiple	multiple	JJ
cord-000257-ampip7od	152	10	sequence	sequence	NN
cord-000257-ampip7od	152	11	alignment	alignment	NN
cord-000257-ampip7od	152	12	aided	aid	VBN
cord-000257-ampip7od	152	13	by	by	IN
cord-000257-ampip7od	152	14	quality	quality	NN
cord-000257-ampip7od	152	15	analysis	analysis	NN
cord-000257-ampip7od	152	16	tools	tool	NNS
cord-000257-ampip7od	152	17	Comparison	comparison	NN
cord-000257-ampip7od	152	18	of	of	IN
cord-000257-ampip7od	152	19	methods	method	NNS
cord-000257-ampip7od	152	20	for	for	IN
cord-000257-ampip7od	152	21	searching	search	VBG
cord-000257-ampip7od	152	22	protein	protein	NN
cord-000257-ampip7od	152	23	sequence	sequence	NN
cord-000257-ampip7od	152	24	databases	database	NNS
cord-000257-ampip7od	153	1	An	an	DT
cord-000257-ampip7od	153	2	insight	insight	NN
cord-000257-ampip7od	153	3	into	into	IN
cord-000257-ampip7od	153	4	domain	domain	NN
cord-000257-ampip7od	153	5	combinations	combination	NNS
cord-000257-ampip7od	153	6	Evolutionary	evolutionary	JJ
cord-000257-ampip7od	153	7	trees	tree	NNS
cord-000257-ampip7od	153	8	from	from	IN
cord-000257-ampip7od	153	9	DNA	dna	NN
cord-000257-ampip7od	153	10	sequences	sequence	NNS
cord-000257-ampip7od	153	11	:	:	:
cord-000257-ampip7od	153	12	a	a	DT
cord-000257-ampip7od	153	13	maximum	maximum	JJ
cord-000257-ampip7od	153	14	likelihood	likelihood	NN
cord-000257-ampip7od	153	15	approach	approach	NN
cord-000257-ampip7od	153	16	MRBAYES	MRBAYES	NNP
cord-000257-ampip7od	153	17	:	:	:
cord-000257-ampip7od	154	1	Bayesian	bayesian	JJ
cord-000257-ampip7od	154	2	inference	inference	NN
cord-000257-ampip7od	154	3	of	of	IN
cord-000257-ampip7od	154	4	phylogenetic	phylogenetic	JJ
cord-000257-ampip7od	154	5	trees	tree	NNS
cord-000257-ampip7od	154	6	Mammalian	mammalian	JJ
cord-000257-ampip7od	154	7	evolution	evolution	NN
cord-000257-ampip7od	154	8	and	and	CC
cord-000257-ampip7od	154	9	biomedicine	biomedicine	NN
cord-000257-ampip7od	154	10	:	:	:
cord-000257-ampip7od	155	1	new	new	JJ
cord-000257-ampip7od	155	2	views	view	NNS
cord-000257-ampip7od	155	3	from	from	IN
cord-000257-ampip7od	155	4	phylogeny	phylogeny	NN
cord-000257-ampip7od	155	5	Multiple	multiple	JJ
cord-000257-ampip7od	155	6	sequence	sequence	NN
cord-000257-ampip7od	155	7	alignment	alignment	NN
cord-000257-ampip7od	155	8	:	:	:
cord-000257-ampip7od	156	1	In	in	IN
cord-000257-ampip7od	156	2	pursuit	pursuit	NN
cord-000257-ampip7od	156	3	of	of	IN
cord-000257-ampip7od	156	4	homologous	homologous	JJ
cord-000257-ampip7od	156	5	DNA	dna	NN
cord-000257-ampip7od	156	6	positions	position	NNS
cord-000257-ampip7od	156	7	Bayesian	bayesian	JJ
cord-000257-ampip7od	156	8	coestimation	coestimation	NN
cord-000257-ampip7od	156	9	of	of	IN
cord-000257-ampip7od	156	10	phylogeny	phylogeny	NN
cord-000257-ampip7od	156	11	and	and	CC
cord-000257-ampip7od	156	12	sequence	sequence	NN
cord-000257-ampip7od	156	13	alignment	alignment	NN
cord-000257-ampip7od	157	1	The	the	DT
cord-000257-ampip7od	157	2	relation	relation	NN
cord-000257-ampip7od	157	3	between	between	IN
cord-000257-ampip7od	157	4	the	the	DT
cord-000257-ampip7od	157	5	divergence	divergence	NN
cord-000257-ampip7od	157	6	of	of	IN
cord-000257-ampip7od	157	7	sequence	sequence	NN
cord-000257-ampip7od	157	8	and	and	CC
cord-000257-ampip7od	157	9	structure	structure	NN
cord-000257-ampip7od	157	10	in	in	IN
cord-000257-ampip7od	157	11	proteins	protein	NNS
cord-000257-ampip7od	158	1	Molecular	molecular	JJ
cord-000257-ampip7od	158	2	evolution	evolution	NN
cord-000257-ampip7od	158	3	of	of	IN
cord-000257-ampip7od	158	4	the	the	DT
cord-000257-ampip7od	158	5	MAGUK	MAGUK	NNP
cord-000257-ampip7od	158	6	family	family	NN
cord-000257-ampip7od	158	7	in	in	IN
cord-000257-ampip7od	158	8	metazoan	metazoan	NN
cord-000257-ampip7od	158	9	genomes	genome	NNS
cord-000257-ampip7od	159	1	Why	why	WRB
cord-000257-ampip7od	159	2	should	should	MD
cord-000257-ampip7od	159	3	we	-PRON-	PRP
cord-000257-ampip7od	159	4	care	care	VB
cord-000257-ampip7od	159	5	about	about	IN
cord-000257-ampip7od	159	6	molecular	molecular	JJ
cord-000257-ampip7od	159	7	coevolution	coevolution	NN
cord-000257-ampip7od	160	1	The	the	DT
cord-000257-ampip7od	160	2	propagation	propagation	NN
cord-000257-ampip7od	160	3	of	of	IN
cord-000257-ampip7od	160	4	binding	bind	VBG
cord-000257-ampip7od	160	5	interactions	interaction	NNS
cord-000257-ampip7od	160	6	to	to	IN
cord-000257-ampip7od	160	7	remote	remote	JJ
cord-000257-ampip7od	160	8	sites	site	NNS
cord-000257-ampip7od	160	9	in	in	IN
cord-000257-ampip7od	160	10	proteins	protein	NNS
cord-000257-ampip7od	160	11	:	:	:
cord-000257-ampip7od	160	12	analysis	analysis	NN
cord-000257-ampip7od	160	13	of	of	IN
cord-000257-ampip7od	160	14	the	the	DT
cord-000257-ampip7od	160	15	binding	binding	NN
cord-000257-ampip7od	160	16	of	of	IN
cord-000257-ampip7od	160	17	the	the	DT
cord-000257-ampip7od	160	18	monoclonal	monoclonal	JJ
cord-000257-ampip7od	160	19	antibody	antibody	NN
cord-000257-ampip7od	160	20	D1.3	D1.3	NNP
cord-000257-ampip7od	160	21	to	to	IN
cord-000257-ampip7od	160	22	lysozyme	lysozyme	NN
cord-000257-ampip7od	160	23	Structural	structural	JJ
cord-000257-ampip7od	160	24	stability	stability	NN
cord-000257-ampip7od	160	25	of	of	IN
cord-000257-ampip7od	160	26	binding	bind	VBG
cord-000257-ampip7od	160	27	sites	site	NNS
cord-000257-ampip7od	160	28	:	:	:
cord-000257-ampip7od	160	29	consequences	consequence	NNS
cord-000257-ampip7od	160	30	for	for	IN
cord-000257-ampip7od	160	31	binding	bind	VBG
cord-000257-ampip7od	160	32	affinity	affinity	NN
cord-000257-ampip7od	160	33	and	and	CC
cord-000257-ampip7od	160	34	allosteric	allosteric	JJ
cord-000257-ampip7od	160	35	effects	effect	NNS
cord-000257-ampip7od	160	36	Revealing	reveal	VBG
cord-000257-ampip7od	160	37	the	the	DT
cord-000257-ampip7od	160	38	architecture	architecture	NN
cord-000257-ampip7od	160	39	of	of	IN
cord-000257-ampip7od	160	40	a	a	DT
cord-000257-ampip7od	160	41	K+	k+	JJ
cord-000257-ampip7od	160	42	channel	channel	NN
cord-000257-ampip7od	160	43	pore	pore	NN
cord-000257-ampip7od	160	44	through	through	IN
cord-000257-ampip7od	160	45	mutant	mutant	JJ
cord-000257-ampip7od	160	46	cycles	cycle	NNS
cord-000257-ampip7od	160	47	with	with	IN
cord-000257-ampip7od	160	48	a	a	DT
cord-000257-ampip7od	160	49	peptide	peptide	JJ
cord-000257-ampip7od	160	50	inhibitor	inhibitor	NN
cord-000257-ampip7od	160	51	Structural	structural	JJ
cord-000257-ampip7od	160	52	plasticity	plasticity	NN
cord-000257-ampip7od	160	53	in	in	IN
cord-000257-ampip7od	160	54	a	a	DT
cord-000257-ampip7od	160	55	remodeled	remodel	VBN
cord-000257-ampip7od	160	56	protein	protein	NN
cord-000257-ampip7od	160	57	-	-	HYPH
cord-000257-ampip7od	160	58	protein	protein	NN
cord-000257-ampip7od	160	59	interface	interface	NN
cord-000257-ampip7od	160	60	A	a	DT
cord-000257-ampip7od	160	61	specificity	specificity	NN
cord-000257-ampip7od	160	62	map	map	NN
cord-000257-ampip7od	160	63	for	for	IN
cord-000257-ampip7od	160	64	the	the	DT
cord-000257-ampip7od	160	65	PDZ	PDZ	NNP
cord-000257-ampip7od	160	66	domain	domain	NN
cord-000257-ampip7od	160	67	family	family	NN
cord-000257-ampip7od	161	1	The	the	DT
cord-000257-ampip7od	161	2	linkage	linkage	NN
cord-000257-ampip7od	161	3	between	between	IN
cord-000257-ampip7od	161	4	protein	protein	NN
cord-000257-ampip7od	161	5	folding	folding	NN
cord-000257-ampip7od	161	6	and	and	CC
cord-000257-ampip7od	161	7	functional	functional	JJ
cord-000257-ampip7od	161	8	cooperativity	cooperativity	NN
cord-000257-ampip7od	161	9	:	:	:
cord-000257-ampip7od	161	10	two	two	CD
cord-000257-ampip7od	161	11	sides	side	NNS
cord-000257-ampip7od	161	12	of	of	IN
cord-000257-ampip7od	161	13	the	the	DT
cord-000257-ampip7od	161	14	same	same	JJ
cord-000257-ampip7od	161	15	coin	coin	NN
cord-000257-ampip7od	161	16	?	?	.
cord-000257-ampip7od	162	1	Empirical	empirical	JJ
cord-000257-ampip7od	162	2	and	and	CC
cord-000257-ampip7od	162	3	structural	structural	JJ
cord-000257-ampip7od	162	4	models	model	NNS
cord-000257-ampip7od	162	5	for	for	IN
cord-000257-ampip7od	162	6	insertions	insertion	NNS
cord-000257-ampip7od	162	7	and	and	CC
cord-000257-ampip7od	162	8	deletions	deletion	NNS
cord-000257-ampip7od	162	9	in	in	IN
cord-000257-ampip7od	162	10	the	the	DT
cord-000257-ampip7od	162	11	divergent	divergent	JJ
cord-000257-ampip7od	162	12	evolution	evolution	NN
cord-000257-ampip7od	162	13	of	of	IN
cord-000257-ampip7od	162	14	proteins	protein	NNS
cord-000257-ampip7od	162	15	Analysis	Analysis	NNP
cord-000257-ampip7od	162	16	of	of	IN
cord-000257-ampip7od	162	17	insertions	insertion	NNS
cord-000257-ampip7od	162	18	/	/	SYM
cord-000257-ampip7od	162	19	deletions	deletion	NNS
cord-000257-ampip7od	162	20	in	in	IN
cord-000257-ampip7od	162	21	protein	protein	NN
cord-000257-ampip7od	162	22	structures	structure	NNS
cord-000257-ampip7od	162	23	Structural	structural	JJ
cord-000257-ampip7od	162	24	similarity	similarity	NN
cord-000257-ampip7od	162	25	of	of	IN
cord-000257-ampip7od	162	26	loops	loop	NNS
cord-000257-ampip7od	162	27	in	in	IN
cord-000257-ampip7od	162	28	protein	protein	NN
cord-000257-ampip7od	162	29	families	family	NNS
cord-000257-ampip7od	162	30	:	:	:
cord-000257-ampip7od	162	31	toward	toward	IN
cord-000257-ampip7od	162	32	the	the	DT
cord-000257-ampip7od	162	33	understanding	understanding	NN
cord-000257-ampip7od	162	34	of	of	IN
cord-000257-ampip7od	162	35	protein	protein	NN
cord-000257-ampip7od	162	36	evolution	evolution	NN
cord-000257-ampip7od	163	1	The	the	DT
cord-000257-ampip7od	163	2	effect	effect	NN
cord-000257-ampip7od	163	3	of	of	IN
cord-000257-ampip7od	163	4	inhibitor	inhibitor	NN
cord-000257-ampip7od	163	5	binding	bind	VBG
cord-000257-ampip7od	163	6	on	on	IN
cord-000257-ampip7od	163	7	the	the	DT
cord-000257-ampip7od	163	8	structural	structural	JJ
cord-000257-ampip7od	163	9	stability	stability	NN
cord-000257-ampip7od	163	10	and	and	CC
cord-000257-ampip7od	163	11	cooperativity	cooperativity	NN
cord-000257-ampip7od	163	12	of	of	IN
cord-000257-ampip7od	163	13	the	the	DT
cord-000257-ampip7od	163	14	HIV-1	HIV-1	NNP
cord-000257-ampip7od	163	15	protease	protease	NN
cord-000257-ampip7od	163	16	Evolutionary	evolutionary	JJ
cord-000257-ampip7od	163	17	conserved	conserve	VBN
cord-000257-ampip7od	163	18	pathways	pathway	NNS
cord-000257-ampip7od	163	19	of	of	IN
cord-000257-ampip7od	163	20	energetic	energetic	JJ
cord-000257-ampip7od	163	21	connectivity	connectivity	NN
cord-000257-ampip7od	163	22	in	in	IN
cord-000257-ampip7od	163	23	protein	protein	NN
cord-000257-ampip7od	163	24	families	family	NNS
cord-000257-ampip7od	164	1	How	how	WRB
cord-000257-ampip7od	164	2	frequent	frequent	JJ
cord-000257-ampip7od	164	3	are	be	VBP
cord-000257-ampip7od	164	4	correlated	correlate	VBN
cord-000257-ampip7od	164	5	changes	change	NNS
cord-000257-ampip7od	164	6	in	in	IN
cord-000257-ampip7od	164	7	families	family	NNS
cord-000257-ampip7od	164	8	of	of	IN
cord-000257-ampip7od	164	9	protein	protein	NN
cord-000257-ampip7od	164	10	sequences	sequence	NNS
cord-000257-ampip7od	164	11	?	?	.
cord-000257-ampip7od	165	1	An	an	DT
cord-000257-ampip7od	165	2	improved	improved	JJ
cord-000257-ampip7od	165	3	method	method	NN
cord-000257-ampip7od	165	4	for	for	IN
cord-000257-ampip7od	165	5	determining	determine	VBG
cord-000257-ampip7od	165	6	codon	codon	NN
cord-000257-ampip7od	165	7	variability	variability	NN
cord-000257-ampip7od	165	8	in	in	IN
cord-000257-ampip7od	165	9	a	a	DT
cord-000257-ampip7od	165	10	gene	gene	NN
cord-000257-ampip7od	165	11	and	and	CC
cord-000257-ampip7od	165	12	its	-PRON-	PRP$
cord-000257-ampip7od	165	13	application	application	NN
cord-000257-ampip7od	165	14	to	to	IN
cord-000257-ampip7od	165	15	the	the	DT
cord-000257-ampip7od	165	16	rate	rate	NN
cord-000257-ampip7od	165	17	of	of	IN
cord-000257-ampip7od	165	18	fixation	fixation	NN
cord-000257-ampip7od	165	19	of	of	IN
cord-000257-ampip7od	165	20	mutations	mutation	NNS
cord-000257-ampip7od	165	21	in	in	IN
cord-000257-ampip7od	165	22	evolution	evolution	NN
cord-000257-ampip7od	165	23	Evolution	evolution	NN
cord-000257-ampip7od	165	24	of	of	IN
cord-000257-ampip7od	165	25	vertebrate	vertebrate	JJ
cord-000257-ampip7od	165	26	genes	gene	NNS
cord-000257-ampip7od	165	27	related	relate	VBN
cord-000257-ampip7od	165	28	to	to	IN
cord-000257-ampip7od	165	29	prion	prion	NN
cord-000257-ampip7od	165	30	and	and	CC
cord-000257-ampip7od	165	31	shadoo	shadoo	NN
cord-000257-ampip7od	165	32	proteins	protein	NNS
cord-000257-ampip7od	165	33	--	--	:
cord-000257-ampip7od	165	34	clues	clue	NNS
cord-000257-ampip7od	165	35	from	from	IN
cord-000257-ampip7od	165	36	comparative	comparative	JJ
cord-000257-ampip7od	165	37	genomic	genomic	JJ
cord-000257-ampip7od	165	38	analysis	analysis	NN
cord-000257-ampip7od	165	39	Evolutionarily	evolutionarily	RB
cord-000257-ampip7od	165	40	conserved	conserved	JJ
cord-000257-ampip7od	165	41	elements	element	NNS
cord-000257-ampip7od	165	42	in	in	IN
cord-000257-ampip7od	165	43	vertebrate	vertebrate	NN
cord-000257-ampip7od	165	44	,	,	,
cord-000257-ampip7od	165	45	insect	insect	NN
cord-000257-ampip7od	165	46	,	,	,
cord-000257-ampip7od	165	47	worm	worm	NN
cord-000257-ampip7od	165	48	,	,	,
cord-000257-ampip7od	165	49	and	and	CC
cord-000257-ampip7od	165	50	yeast	yeast	NN
cord-000257-ampip7od	165	51	genomes	genome	NNS
cord-000257-ampip7od	165	52	Data	Data	NNP
cord-000257-ampip7od	165	53	growth	growth	NN
cord-000257-ampip7od	165	54	and	and	CC
cord-000257-ampip7od	165	55	its	-PRON-	PRP$
cord-000257-ampip7od	165	56	impact	impact	NN
cord-000257-ampip7od	165	57	on	on	IN
cord-000257-ampip7od	165	58	the	the	DT
cord-000257-ampip7od	165	59	SCOP	SCOP	NNP
cord-000257-ampip7od	165	60	database	database	NN
cord-000257-ampip7od	165	61	:	:	:
cord-000257-ampip7od	165	62	new	new	JJ
cord-000257-ampip7od	165	63	developments	development	NNS
cord-000257-ampip7od	165	64	Estimating	estimate	VBG
cord-000257-ampip7od	165	65	the	the	DT
cord-000257-ampip7od	165	66	number	number	NN
cord-000257-ampip7od	165	67	of	of	IN
cord-000257-ampip7od	165	68	protein	protein	NN
cord-000257-ampip7od	165	69	folds	fold	NNS
cord-000257-ampip7od	165	70	and	and	CC
cord-000257-ampip7od	165	71	families	family	NNS
cord-000257-ampip7od	165	72	from	from	IN
cord-000257-ampip7od	165	73	complete	complete	JJ
cord-000257-ampip7od	165	74	genome	genome	NN
cord-000257-ampip7od	165	75	data	datum	NNS
cord-000257-ampip7od	165	76	Insights	insight	NNS
cord-000257-ampip7od	165	77	into	into	IN
cord-000257-ampip7od	165	78	the	the	DT
cord-000257-ampip7od	165	79	molecular	molecular	JJ
cord-000257-ampip7od	165	80	evolution	evolution	NN
cord-000257-ampip7od	165	81	of	of	IN
cord-000257-ampip7od	165	82	the	the	DT
cord-000257-ampip7od	165	83	PDZ	PDZ	NNP
cord-000257-ampip7od	165	84	-	-	HYPH
cord-000257-ampip7od	165	85	LIM	LIM	NNP
cord-000257-ampip7od	165	86	family	family	NN
cord-000257-ampip7od	165	87	and	and	CC
cord-000257-ampip7od	165	88	indentification	indentification	NN
cord-000257-ampip7od	165	89	of	of	IN
cord-000257-ampip7od	165	90	a	a	DT
cord-000257-ampip7od	165	91	novel	novel	JJ
cord-000257-ampip7od	165	92	conserved	conserve	VBN
cord-000257-ampip7od	165	93	protein	protein	NN
cord-000257-ampip7od	165	94	motif	motif	NN
cord-000257-ampip7od	166	1	Independent	independent	JJ
cord-000257-ampip7od	166	2	elaboration	elaboration	NN
cord-000257-ampip7od	166	3	of	of	IN
cord-000257-ampip7od	166	4	steroid	steroid	NN
cord-000257-ampip7od	166	5	hormone	hormone	NN
cord-000257-ampip7od	166	6	signaling	signal	VBG
cord-000257-ampip7od	166	7	pathways	pathway	NNS
cord-000257-ampip7od	166	8	in	in	IN
cord-000257-ampip7od	166	9	metazoans	metazoans	NNP
cord-000257-ampip7od	166	10	Integration	integration	NN
cord-000257-ampip7od	166	11	of	of	IN
cord-000257-ampip7od	166	12	horizontally	horizontally	RB
cord-000257-ampip7od	166	13	transferred	transfer	VBN
cord-000257-ampip7od	166	14	genes	gene	NNS
cord-000257-ampip7od	166	15	into	into	IN
cord-000257-ampip7od	166	16	regulatory	regulatory	JJ
cord-000257-ampip7od	166	17	interaction	interaction	NN
cord-000257-ampip7od	166	18	networks	network	NNS
cord-000257-ampip7od	166	19	takes	take	VBZ
cord-000257-ampip7od	166	20	many	many	JJ
cord-000257-ampip7od	166	21	million	million	CD
cord-000257-ampip7od	166	22	years	year	NNS
cord-000257-ampip7od	166	23	Prokaryotic	prokaryotic	JJ
cord-000257-ampip7od	166	24	evolution	evolution	NN
cord-000257-ampip7od	166	25	in	in	IN
cord-000257-ampip7od	166	26	light	light	NN
cord-000257-ampip7od	166	27	of	of	IN
cord-000257-ampip7od	166	28	gene	gene	NN
cord-000257-ampip7od	166	29	transfer	transfer	NN
cord-000257-ampip7od	167	1	How	how	WRB
cord-000257-ampip7od	167	2	the	the	DT
cord-000257-ampip7od	167	3	global	global	JJ
cord-000257-ampip7od	167	4	structure	structure	NN
cord-000257-ampip7od	167	5	of	of	IN
cord-000257-ampip7od	167	6	protein	protein	NN
cord-000257-ampip7od	167	7	interaction	interaction	NN
cord-000257-ampip7od	167	8	networks	network	NNS
cord-000257-ampip7od	167	9	evolves	evolve	VBZ
cord-000257-ampip7od	167	10	The	the	DT
cord-000257-ampip7od	167	11	impact	impact	NN
cord-000257-ampip7od	167	12	of	of	IN
cord-000257-ampip7od	167	13	comparative	comparative	JJ
cord-000257-ampip7od	167	14	genomics	genomic	NNS
cord-000257-ampip7od	167	15	on	on	IN
cord-000257-ampip7od	167	16	our	-PRON-	PRP$
cord-000257-ampip7od	167	17	understanding	understanding	NN
cord-000257-ampip7od	167	18	of	of	IN
cord-000257-ampip7od	167	19	evolution	evolution	NN
cord-000257-ampip7od	167	20	Modular	modular	JJ
cord-000257-ampip7od	167	21	genes	gene	NNS
cord-000257-ampip7od	167	22	with	with	IN
cord-000257-ampip7od	167	23	metazoan	metazoan	NN
cord-000257-ampip7od	167	24	-	-	HYPH
cord-000257-ampip7od	167	25	specific	specific	JJ
cord-000257-ampip7od	167	26	domains	domain	NNS
cord-000257-ampip7od	167	27	have	have	VBP
cord-000257-ampip7od	167	28	increased	increase	VBN
cord-000257-ampip7od	167	29	tissue	tissue	NN
cord-000257-ampip7od	167	30	specificity	specificity	NN
cord-000257-ampip7od	167	31	Evolution	evolution	NN
cord-000257-ampip7od	167	32	of	of	IN
cord-000257-ampip7od	167	33	protein	protein	NN
cord-000257-ampip7od	167	34	domain	domain	NN
cord-000257-ampip7od	167	35	promiscuity	promiscuity	NN
cord-000257-ampip7od	167	36	in	in	IN
cord-000257-ampip7od	167	37	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	168	1	The	the	DT
cord-000257-ampip7od	168	2	structure	structure	NN
cord-000257-ampip7od	168	3	of	of	IN
cord-000257-ampip7od	168	4	the	the	DT
cord-000257-ampip7od	168	5	protein	protein	NN
cord-000257-ampip7od	168	6	universe	universe	NN
cord-000257-ampip7od	168	7	and	and	CC
cord-000257-ampip7od	168	8	genome	genome	NN
cord-000257-ampip7od	168	9	evolution	evolution	NN
cord-000257-ampip7od	168	10	Modules	module	NNS
cord-000257-ampip7od	168	11	,	,	,
cord-000257-ampip7od	168	12	multidomain	multidomain	NN
cord-000257-ampip7od	168	13	proteins	protein	NNS
cord-000257-ampip7od	168	14	and	and	CC
cord-000257-ampip7od	168	15	organismic	organismic	JJ
cord-000257-ampip7od	168	16	complexity	complexity	NN
cord-000257-ampip7od	169	1	Detecting	detect	VBG
cord-000257-ampip7od	169	2	protein	protein	NN
cord-000257-ampip7od	169	3	function	function	NN
cord-000257-ampip7od	169	4	and	and	CC
cord-000257-ampip7od	169	5	protein	protein	NN
cord-000257-ampip7od	169	6	-	-	HYPH
cord-000257-ampip7od	169	7	protein	protein	NN
cord-000257-ampip7od	169	8	interaction	interaction	NN
cord-000257-ampip7od	169	9	from	from	IN
cord-000257-ampip7od	169	10	genome	genome	NN
cord-000257-ampip7od	169	11	sequences	sequence	NNS
cord-000257-ampip7od	169	12	Lethality	lethality	NN
cord-000257-ampip7od	169	13	and	and	CC
cord-000257-ampip7od	169	14	centrality	centrality	NN
cord-000257-ampip7od	169	15	in	in	IN
cord-000257-ampip7od	169	16	protein	protein	NN
cord-000257-ampip7od	169	17	networks	network	NNS
cord-000257-ampip7od	170	1	Comparative	comparative	JJ
cord-000257-ampip7od	170	2	genomics	genomic	NNS
cord-000257-ampip7od	170	3	of	of	IN
cord-000257-ampip7od	170	4	centrality	centrality	NN
cord-000257-ampip7od	170	5	and	and	CC
cord-000257-ampip7od	170	6	essentiality	essentiality	NN
cord-000257-ampip7od	170	7	in	in	IN
cord-000257-ampip7od	170	8	three	three	CD
cord-000257-ampip7od	170	9	eukaryotic	eukaryotic	JJ
cord-000257-ampip7od	170	10	protein	protein	NN
cord-000257-ampip7od	170	11	-	-	HYPH
cord-000257-ampip7od	170	12	interaction	interaction	NN
cord-000257-ampip7od	170	13	networks	network	NNS
cord-000257-ampip7od	170	14	Domain	domain	NN
cord-000257-ampip7od	170	15	deletions	deletion	NNS
cord-000257-ampip7od	170	16	and	and	CC
cord-000257-ampip7od	170	17	substitutions	substitution	NNS
cord-000257-ampip7od	170	18	in	in	IN
cord-000257-ampip7od	170	19	the	the	DT
cord-000257-ampip7od	170	20	modular	modular	JJ
cord-000257-ampip7od	170	21	protein	protein	NN
cord-000257-ampip7od	170	22	evolution	evolution	NN
cord-000257-ampip7od	170	23	Genome	Genome	NNP
cord-000257-ampip7od	170	24	evolution	evolution	NN
cord-000257-ampip7od	170	25	and	and	CC
cord-000257-ampip7od	170	26	the	the	DT
cord-000257-ampip7od	170	27	evolution	evolution	NN
cord-000257-ampip7od	170	28	of	of	IN
cord-000257-ampip7od	170	29	exon	exon	NN
cord-000257-ampip7od	170	30	-	-	HYPH
cord-000257-ampip7od	170	31	shuffling	shuffle	VBG
cord-000257-ampip7od	170	32	-	-	HYPH
cord-000257-ampip7od	170	33	a	a	DT
cord-000257-ampip7od	170	34	review	review	NN
cord-000257-ampip7od	170	35	Significant	significant	JJ
cord-000257-ampip7od	170	36	expansion	expansion	NN
cord-000257-ampip7od	170	37	of	of	IN
cord-000257-ampip7od	170	38	exon	exon	NN
cord-000257-ampip7od	170	39	-	-	HYPH
cord-000257-ampip7od	170	40	bordering	border	VBG
cord-000257-ampip7od	170	41	protein	protein	NN
cord-000257-ampip7od	170	42	domains	domain	NNS
cord-000257-ampip7od	170	43	during	during	IN
cord-000257-ampip7od	170	44	animal	animal	NN
cord-000257-ampip7od	170	45	proteome	proteome	NN
cord-000257-ampip7od	170	46	evolution	evolution	NN
cord-000257-ampip7od	170	47	Thermodynamic	thermodynamic	JJ
cord-000257-ampip7od	170	48	basis	basis	NN
cord-000257-ampip7od	170	49	for	for	IN
cord-000257-ampip7od	170	50	promiscuity	promiscuity	NN
cord-000257-ampip7od	170	51	and	and	CC
cord-000257-ampip7od	170	52	selectivity	selectivity	NN
cord-000257-ampip7od	170	53	in	in	IN
cord-000257-ampip7od	170	54	protein	protein	NN
cord-000257-ampip7od	170	55	-	-	HYPH
cord-000257-ampip7od	170	56	protein	protein	NN
cord-000257-ampip7od	170	57	interactions	interaction	NNS
cord-000257-ampip7od	170	58	:	:	:
cord-000257-ampip7od	170	59	PDZ	PDZ	NNP
cord-000257-ampip7od	170	60	domains	domain	NNS
cord-000257-ampip7od	170	61	,	,	,
cord-000257-ampip7od	170	62	a	a	DT
cord-000257-ampip7od	170	63	case	case	NN
cord-000257-ampip7od	170	64	study	study	NN
cord-000257-ampip7od	170	65	Promiscuous	promiscuous	JJ
cord-000257-ampip7od	170	66	binding	bind	VBG
cord-000257-ampip7od	170	67	nature	nature	NN
cord-000257-ampip7od	170	68	of	of	IN
cord-000257-ampip7od	170	69	SH3	SH3	NNP
cord-000257-ampip7od	170	70	domains	domain	NNS
cord-000257-ampip7od	170	71	to	to	IN
cord-000257-ampip7od	170	72	their	-PRON-	PRP$
cord-000257-ampip7od	170	73	target	target	NN
cord-000257-ampip7od	170	74	proteins	protein	NNS
cord-000257-ampip7od	170	75	Expansion	Expansion	NNP
cord-000257-ampip7od	170	76	of	of	IN
cord-000257-ampip7od	170	77	genome	genome	NN
cord-000257-ampip7od	170	78	coding	coding	NN
cord-000257-ampip7od	170	79	regions	region	NNS
cord-000257-ampip7od	170	80	by	by	IN
cord-000257-ampip7od	170	81	acquisition	acquisition	NN
cord-000257-ampip7od	170	82	of	of	IN
cord-000257-ampip7od	170	83	new	new	JJ
cord-000257-ampip7od	170	84	genes	gene	NNS
cord-000257-ampip7od	171	1	The	the	DT
cord-000257-ampip7od	171	2	geometry	geometry	NN
cord-000257-ampip7od	171	3	of	of	IN
cord-000257-ampip7od	171	4	domain	domain	NN
cord-000257-ampip7od	171	5	combination	combination	NN
cord-000257-ampip7od	171	6	in	in	IN
cord-000257-ampip7od	171	7	proteins	protein	NNS
cord-000257-ampip7od	172	1	Different	different	JJ
cord-000257-ampip7od	172	2	levels	level	NNS
cord-000257-ampip7od	172	3	of	of	IN
cord-000257-ampip7od	172	4	alternative	alternative	JJ
cord-000257-ampip7od	172	5	splicing	splicing	NN
cord-000257-ampip7od	172	6	among	among	IN
cord-000257-ampip7od	172	7	eukaryotes	eukaryote	NNS
cord-000257-ampip7od	173	1	How	how	WRB
cord-000257-ampip7od	173	2	did	do	VBD
cord-000257-ampip7od	173	3	alternative	alternative	JJ
cord-000257-ampip7od	173	4	splicing	splicing	NN
cord-000257-ampip7od	173	5	evolve	evolve	VB
cord-000257-ampip7od	173	6	?	?	.
cord-000257-ampip7od	174	1	Alternative	alternative	JJ
cord-000257-ampip7od	174	2	splicing	splicing	NN
cord-000257-ampip7od	174	3	and	and	CC
cord-000257-ampip7od	174	4	gene	gene	NN
cord-000257-ampip7od	174	5	duplication	duplication	NN
cord-000257-ampip7od	174	6	are	be	VBP
cord-000257-ampip7od	174	7	inversely	inversely	RB
cord-000257-ampip7od	174	8	correlated	correlate	VBN
cord-000257-ampip7od	174	9	evolutionary	evolutionary	JJ
cord-000257-ampip7od	174	10	mechanisms	mechanism	NNS
cord-000257-ampip7od	174	11	Polyploidy	polyploidy	NN
cord-000257-ampip7od	174	12	and	and	CC
cord-000257-ampip7od	174	13	genome	genome	NN
cord-000257-ampip7od	174	14	evolution	evolution	NN
cord-000257-ampip7od	174	15	in	in	IN
cord-000257-ampip7od	174	16	plants	plant	NNS
cord-000257-ampip7od	175	1	Comparative	comparative	JJ
cord-000257-ampip7od	175	2	analysis	analysis	NN
cord-000257-ampip7od	175	3	indicates	indicate	VBZ
cord-000257-ampip7od	175	4	that	that	IN
cord-000257-ampip7od	175	5	alternative	alternative	JJ
cord-000257-ampip7od	175	6	splicing	splicing	NN
cord-000257-ampip7od	175	7	in	in	IN
cord-000257-ampip7od	175	8	plants	plant	NNS
cord-000257-ampip7od	175	9	has	have	VBZ
cord-000257-ampip7od	175	10	a	a	DT
cord-000257-ampip7od	175	11	limited	limited	JJ
cord-000257-ampip7od	175	12	role	role	NN
cord-000257-ampip7od	175	13	in	in	IN
cord-000257-ampip7od	175	14	functional	functional	JJ
cord-000257-ampip7od	175	15	expansion	expansion	NN
cord-000257-ampip7od	175	16	of	of	IN
cord-000257-ampip7od	175	17	the	the	DT
cord-000257-ampip7od	175	18	proteome	proteome	NN
cord-000257-ampip7od	175	19	Structural	structural	JJ
cord-000257-ampip7od	175	20	characterization	characterization	NN
cord-000257-ampip7od	175	21	of	of	IN
cord-000257-ampip7od	175	22	the	the	DT
cord-000257-ampip7od	175	23	intramolecular	intramolecular	JJ
cord-000257-ampip7od	175	24	interaction	interaction	NN
cord-000257-ampip7od	175	25	between	between	IN
cord-000257-ampip7od	175	26	the	the	DT
cord-000257-ampip7od	175	27	SH3	SH3	NNP
cord-000257-ampip7od	175	28	and	and	CC
cord-000257-ampip7od	175	29	guanylate	guanylate	NNP
cord-000257-ampip7od	175	30	kinase	kinase	NN
cord-000257-ampip7od	175	31	domains	domain	NNS
cord-000257-ampip7od	175	32	of	of	IN
cord-000257-ampip7od	175	33	PSD-95	PSD-95	NNP
cord-000257-ampip7od	175	34	Identification	Identification	NNP
cord-000257-ampip7od	175	35	of	of	IN
cord-000257-ampip7od	175	36	an	an	DT
cord-000257-ampip7od	175	37	Intramolecular	Intramolecular	NNP
cord-000257-ampip7od	175	38	Interaction	Interaction	NNP
cord-000257-ampip7od	175	39	between	between	IN
cord-000257-ampip7od	175	40	the	the	DT
cord-000257-ampip7od	175	41	SH3	SH3	NNP
cord-000257-ampip7od	175	42	and	and	CC
cord-000257-ampip7od	175	43	Guanylate	Guanylate	NNP
cord-000257-ampip7od	175	44	Kinase	Kinase	NNP
cord-000257-ampip7od	175	45	Domains	domain	NNS
cord-000257-ampip7od	175	46	of	of	IN
cord-000257-ampip7od	175	47	PSD-95	PSD-95	NNP
cord-000257-ampip7od	176	1	Interplay	interplay	NN
cord-000257-ampip7od	176	2	of	of	IN
cord-000257-ampip7od	176	3	PDZ	pdz	NN
cord-000257-ampip7od	176	4	and	and	CC
cord-000257-ampip7od	176	5	protease	protease	NN
cord-000257-ampip7od	176	6	domain	domain	NN
cord-000257-ampip7od	176	7	of	of	IN
cord-000257-ampip7od	176	8	DegP	DegP	NNP
cord-000257-ampip7od	176	9	ensures	ensure	VBZ
cord-000257-ampip7od	176	10	efficient	efficient	JJ
cord-000257-ampip7od	176	11	elimination	elimination	NN
cord-000257-ampip7od	176	12	of	of	IN
cord-000257-ampip7od	176	13	misfolded	misfolde	VBN
cord-000257-ampip7od	176	14	proteins	protein	NNS
cord-000257-ampip7od	176	15	Comparative	comparative	JJ
cord-000257-ampip7od	176	16	biology	biology	NN
cord-000257-ampip7od	176	17	:	:	:
cord-000257-ampip7od	177	1	beyond	beyond	IN
cord-000257-ampip7od	177	2	sequence	sequence	NN
cord-000257-ampip7od	177	3	analysis	analysis	NN
cord-000257-ampip7od	178	1	A	a	DT
cord-000257-ampip7od	178	2	genetic	genetic	JJ
cord-000257-ampip7od	178	3	signature	signature	NN
cord-000257-ampip7od	178	4	of	of	IN
cord-000257-ampip7od	178	5	interspecies	interspecie	NNS
cord-000257-ampip7od	178	6	variations	variation	NNS
cord-000257-ampip7od	178	7	in	in	IN
cord-000257-ampip7od	178	8	gene	gene	NN
cord-000257-ampip7od	178	9	expression	expression	NN
cord-000257-ampip7od	178	10	Genome	genome	NN
cord-000257-ampip7od	178	11	-	-	HYPH
cord-000257-ampip7od	178	12	wide	wide	JJ
cord-000257-ampip7od	178	13	scan	scan	JJ
cord-000257-ampip7od	178	14	reveals	reveal	NNS
cord-000257-ampip7od	178	15	that	that	IN
cord-000257-ampip7od	178	16	genetic	genetic	JJ
cord-000257-ampip7od	178	17	variation	variation	NN
cord-000257-ampip7od	178	18	for	for	IN
cord-000257-ampip7od	178	19	transcriptional	transcriptional	JJ
cord-000257-ampip7od	178	20	plasticity	plasticity	NN
cord-000257-ampip7od	178	21	in	in	IN
cord-000257-ampip7od	178	22	yeast	yeast	NN
cord-000257-ampip7od	178	23	is	be	VBZ
cord-000257-ampip7od	178	24	biased	bias	VBN
cord-000257-ampip7od	178	25	towards	towards	IN
cord-000257-ampip7od	178	26	multi	multi	JJ
cord-000257-ampip7od	178	27	-	-	JJ
cord-000257-ampip7od	178	28	copy	copy	JJ
cord-000257-ampip7od	178	29	and	and	CC
cord-000257-ampip7od	178	30	dispensable	dispensable	JJ
cord-000257-ampip7od	178	31	genes	gene	NNS
cord-000257-ampip7od	178	32	Identification	Identification	NNP
cord-000257-ampip7od	178	33	of	of	IN
cord-000257-ampip7od	178	34	tightly	tightly	RB
cord-000257-ampip7od	178	35	regulated	regulated	JJ
cord-000257-ampip7od	178	36	groups	group	NNS
cord-000257-ampip7od	178	37	of	of	IN
cord-000257-ampip7od	178	38	genes	gene	NNS
cord-000257-ampip7od	178	39	during	during	IN
cord-000257-ampip7od	178	40	Drosophila	drosophila	JJ
cord-000257-ampip7od	178	41	melanogaster	melanogaster	NN
cord-000257-ampip7od	178	42	embryogenesis	embryogenesis	NN
cord-000257-ampip7od	179	1	A	a	DT
cord-000257-ampip7od	179	2	gene	gene	NN
cord-000257-ampip7od	179	3	-	-	HYPH
cord-000257-ampip7od	179	4	coexpression	coexpression	NN
cord-000257-ampip7od	179	5	network	network	NN
cord-000257-ampip7od	179	6	for	for	IN
cord-000257-ampip7od	179	7	global	global	JJ
cord-000257-ampip7od	179	8	discovery	discovery	NN
cord-000257-ampip7od	179	9	of	of	IN
cord-000257-ampip7od	179	10	conserved	conserved	JJ
cord-000257-ampip7od	179	11	genetic	genetic	JJ
cord-000257-ampip7od	179	12	modules	module	NNS
cord-000257-ampip7od	179	13	Similarities	Similarities	NNPS
cord-000257-ampip7od	179	14	and	and	CC
cord-000257-ampip7od	179	15	Differences	Differences	NNPS
cord-000257-ampip7od	179	16	in	in	IN
cord-000257-ampip7od	179	17	Genome	Genome	NNP
cord-000257-ampip7od	179	18	-	-	HYPH
cord-000257-ampip7od	179	19	Wide	wide	JJ
cord-000257-ampip7od	179	20	Expression	expression	NN
cord-000257-ampip7od	179	21	Data	datum	NNS
cord-000257-ampip7od	179	22	of	of	IN
cord-000257-ampip7od	179	23	Six	six	CD
cord-000257-ampip7od	179	24	Organisms	organism	NNS
cord-000257-ampip7od	179	25	Accurate	accurate	JJ
cord-000257-ampip7od	179	26	prediction	prediction	NN
cord-000257-ampip7od	179	27	of	of	IN
cord-000257-ampip7od	179	28	proteinprotein	proteinprotein	NNP
cord-000257-ampip7od	179	29	interactions	interaction	NNS
cord-000257-ampip7od	179	30	from	from	IN
cord-000257-ampip7od	179	31	sequence	sequence	NN
cord-000257-ampip7od	179	32	alignments	alignment	NNS
cord-000257-ampip7od	179	33	using	use	VBG
cord-000257-ampip7od	179	34	a	a	DT
cord-000257-ampip7od	179	35	Bayesian	bayesian	JJ
cord-000257-ampip7od	179	36	method	method	NN
cord-000257-ampip7od	179	37	Correlated	correlate	VBN
cord-000257-ampip7od	179	38	mutations	mutation	NNS
cord-000257-ampip7od	179	39	contain	contain	VBP
cord-000257-ampip7od	179	40	information	information	NN
cord-000257-ampip7od	179	41	about	about	IN
cord-000257-ampip7od	179	42	protein	protein	NN
cord-000257-ampip7od	179	43	-	-	HYPH
cord-000257-ampip7od	179	44	protein	protein	NN
cord-000257-ampip7od	179	45	interaction	interaction	NN
cord-000257-ampip7od	179	46	Mutually	mutually	RB
cord-000257-ampip7od	179	47	compensatory	compensatory	JJ
cord-000257-ampip7od	179	48	mutations	mutation	NNS
cord-000257-ampip7od	179	49	during	during	IN
cord-000257-ampip7od	179	50	evolution	evolution	NN
cord-000257-ampip7od	179	51	of	of	IN
cord-000257-ampip7od	179	52	the	the	DT
cord-000257-ampip7od	179	53	tetramerization	tetramerization	NN
cord-000257-ampip7od	179	54	domain	domain	NN
cord-000257-ampip7od	179	55	of	of	IN
cord-000257-ampip7od	179	56	tumor	tumor	NN
cord-000257-ampip7od	179	57	suppressor	suppressor	NN
cord-000257-ampip7od	179	58	p53	p53	NN
cord-000257-ampip7od	179	59	lead	lead	NN
cord-000257-ampip7od	179	60	to	to	IN
cord-000257-ampip7od	179	61	impaired	impaired	JJ
cord-000257-ampip7od	179	62	hetero	hetero	JJ
cord-000257-ampip7od	179	63	-	-	HYPH
cord-000257-ampip7od	179	64	oligomerization	oligomerization	JJ
cord-000257-ampip7od	179	65	Functional	functional	JJ
cord-000257-ampip7od	179	66	organization	organization	NN
cord-000257-ampip7od	179	67	of	of	IN
cord-000257-ampip7od	179	68	the	the	DT
cord-000257-ampip7od	179	69	yeast	yeast	NN
cord-000257-ampip7od	179	70	proteome	proteome	NN
cord-000257-ampip7od	179	71	by	by	IN
cord-000257-ampip7od	179	72	systematic	systematic	JJ
cord-000257-ampip7od	179	73	analysis	analysis	NN
cord-000257-ampip7od	179	74	of	of	IN
cord-000257-ampip7od	179	75	protein	protein	NN
cord-000257-ampip7od	179	76	complexes	complex	NNS
cord-000257-ampip7od	180	1	A	a	DT
cord-000257-ampip7od	180	2	human	human	JJ
cord-000257-ampip7od	180	3	protein	protein	NN
cord-000257-ampip7od	180	4	-	-	HYPH
cord-000257-ampip7od	180	5	protein	protein	NN
cord-000257-ampip7od	180	6	interaction	interaction	NN
cord-000257-ampip7od	180	7	network	network	NN
cord-000257-ampip7od	180	8	:	:	:
cord-000257-ampip7od	180	9	a	a	DT
cord-000257-ampip7od	180	10	resource	resource	NN
cord-000257-ampip7od	180	11	for	for	IN
cord-000257-ampip7od	180	12	annotating	annotate	VBG
cord-000257-ampip7od	180	13	the	the	DT
cord-000257-ampip7od	180	14	proteome	proteome	NN
cord-000257-ampip7od	180	15	Protein	Protein	NNP
cord-000257-ampip7od	180	16	function	function	NN
cord-000257-ampip7od	180	17	,	,	,
cord-000257-ampip7od	180	18	connectivity	connectivity	NN
cord-000257-ampip7od	180	19	,	,	,
cord-000257-ampip7od	180	20	and	and	CC
cord-000257-ampip7od	180	21	duplicability	duplicability	NN
cord-000257-ampip7od	180	22	in	in	IN
cord-000257-ampip7od	180	23	yeast	yeast	NN
cord-000257-ampip7od	180	24	Evolution	evolution	NN
cord-000257-ampip7od	180	25	and	and	CC
cord-000257-ampip7od	180	26	topology	topology	NN
cord-000257-ampip7od	180	27	in	in	IN
cord-000257-ampip7od	180	28	the	the	DT
cord-000257-ampip7od	180	29	yeast	yeast	NN
cord-000257-ampip7od	180	30	protein	protein	NN
cord-000257-ampip7od	180	31	interaction	interaction	NN
cord-000257-ampip7od	180	32	network	network	NN
cord-000257-ampip7od	180	33	Modularity	modularity	NN
cord-000257-ampip7od	180	34	and	and	CC
cord-000257-ampip7od	180	35	evolutionary	evolutionary	JJ
cord-000257-ampip7od	180	36	constraint	constraint	NN
cord-000257-ampip7od	180	37	on	on	IN
cord-000257-ampip7od	180	38	proteins	protein	NNS
cord-000257-ampip7od	181	1	Comparing	compare	VBG
cord-000257-ampip7od	181	2	genomic	genomic	JJ
cord-000257-ampip7od	181	3	expression	expression	NN
cord-000257-ampip7od	181	4	patterns	pattern	NNS
cord-000257-ampip7od	181	5	across	across	IN
cord-000257-ampip7od	181	6	species	specie	NNS
cord-000257-ampip7od	181	7	identifies	identify	VBZ
cord-000257-ampip7od	181	8	shared	share	VBN
cord-000257-ampip7od	181	9	transcriptional	transcriptional	JJ
cord-000257-ampip7od	181	10	profile	profile	NN
cord-000257-ampip7od	181	11	in	in	IN
cord-000257-ampip7od	181	12	aging	age	VBG
cord-000257-ampip7od	181	13	Genome	genome	NN
cord-000257-ampip7od	181	14	-	-	HYPH
cord-000257-ampip7od	181	15	wide	wide	JJ
cord-000257-ampip7od	181	16	functional	functional	JJ
cord-000257-ampip7od	181	17	analysis	analysis	NN
cord-000257-ampip7od	181	18	of	of	IN
cord-000257-ampip7od	181	19	pathogenicity	pathogenicity	NN
cord-000257-ampip7od	181	20	genes	gene	NNS
cord-000257-ampip7od	181	21	in	in	IN
cord-000257-ampip7od	181	22	the	the	DT
cord-000257-ampip7od	181	23	rice	rice	NN
cord-000257-ampip7od	181	24	blast	blast	NN
cord-000257-ampip7od	181	25	fungus	fungus	NN
cord-000257-ampip7od	182	1	A	a	DT
cord-000257-ampip7od	182	2	mutation	mutation	NN
cord-000257-ampip7od	182	3	accumulation	accumulation	NN
cord-000257-ampip7od	182	4	assay	assay	NN
cord-000257-ampip7od	182	5	reveals	reveal	VBZ
cord-000257-ampip7od	182	6	a	a	DT
cord-000257-ampip7od	182	7	broad	broad	JJ
cord-000257-ampip7od	182	8	capacity	capacity	NN
cord-000257-ampip7od	182	9	for	for	IN
cord-000257-ampip7od	182	10	rapid	rapid	JJ
cord-000257-ampip7od	182	11	evolution	evolution	NN
cord-000257-ampip7od	182	12	of	of	IN
cord-000257-ampip7od	182	13	gene	gene	NN
cord-000257-ampip7od	182	14	expression	expression	NN
cord-000257-ampip7od	182	15	Evolution	evolution	NN
cord-000257-ampip7od	182	16	of	of	IN
cord-000257-ampip7od	182	17	gene	gene	NN
cord-000257-ampip7od	182	18	expression	expression	NN
cord-000257-ampip7od	182	19	in	in	IN
cord-000257-ampip7od	182	20	the	the	DT
cord-000257-ampip7od	182	21	Drosophila	drosophila	JJ
cord-000257-ampip7od	182	22	melanogaster	melanogaster	NN
cord-000257-ampip7od	182	23	subgroup	subgroup	NN
cord-000257-ampip7od	182	24	Sexdependent	Sexdependent	NNP
cord-000257-ampip7od	182	25	gene	gene	NN
cord-000257-ampip7od	182	26	expression	expression	NN
cord-000257-ampip7od	182	27	and	and	CC
cord-000257-ampip7od	182	28	evolution	evolution	NN
cord-000257-ampip7od	182	29	of	of	IN
cord-000257-ampip7od	182	30	the	the	DT
cord-000257-ampip7od	182	31	Drosophila	Drosophila	NNP
cord-000257-ampip7od	182	32	transcriptome	transcriptome	NN
cord-000257-ampip7od	182	33	Microarray	Microarray	NNP
cord-000257-ampip7od	182	34	analysis	analysis	NN
cord-000257-ampip7od	182	35	of	of	IN
cord-000257-ampip7od	182	36	Drosophila	Drosophila	NNP
cord-000257-ampip7od	182	37	development	development	NN
cord-000257-ampip7od	182	38	during	during	IN
cord-000257-ampip7od	182	39	metamorphosis	metamorphosis	NN
cord-000257-ampip7od	182	40	Conservation	conservation	NN
cord-000257-ampip7od	182	41	and	and	CC
cord-000257-ampip7od	182	42	coevolution	coevolution	NN
cord-000257-ampip7od	182	43	in	in	IN
cord-000257-ampip7od	182	44	the	the	DT
cord-000257-ampip7od	182	45	scale	scale	NN
cord-000257-ampip7od	182	46	-	-	HYPH
cord-000257-ampip7od	182	47	free	free	JJ
cord-000257-ampip7od	182	48	human	human	JJ
cord-000257-ampip7od	182	49	gene	gene	NN
cord-000257-ampip7od	182	50	coexpression	coexpression	NNP
cord-000257-ampip7od	182	51	network	network	NN
cord-000257-ampip7od	182	52	Conservation	Conservation	NNP
cord-000257-ampip7od	182	53	and	and	CC
cord-000257-ampip7od	182	54	evolution	evolution	NN
cord-000257-ampip7od	182	55	of	of	IN
cord-000257-ampip7od	182	56	gene	gene	NN
cord-000257-ampip7od	182	57	coexpression	coexpression	NN
cord-000257-ampip7od	182	58	networks	network	NNS
cord-000257-ampip7od	182	59	in	in	IN
cord-000257-ampip7od	182	60	human	human	JJ
cord-000257-ampip7od	182	61	and	and	CC
cord-000257-ampip7od	182	62	chimpanzee	chimpanzee	NN
cord-000257-ampip7od	182	63	brains	brain	NNS
cord-000257-ampip7od	182	64	Cross	Cross	NNP
cord-000257-ampip7od	182	65	-	-	HYPH
cord-000257-ampip7od	182	66	species	species	JJ
cord-000257-ampip7od	182	67	sequence	sequence	NN
cord-000257-ampip7od	182	68	comparisons	comparison	NNS
cord-000257-ampip7od	182	69	:	:	:
cord-000257-ampip7od	182	70	a	a	DT
cord-000257-ampip7od	182	71	review	review	NN
cord-000257-ampip7od	182	72	of	of	IN
cord-000257-ampip7od	182	73	methods	method	NNS
cord-000257-ampip7od	182	74	and	and	CC
cord-000257-ampip7od	182	75	available	available	JJ
cord-000257-ampip7od	182	76	resources	resource	NNS
cord-000257-ampip7od	182	77	Impact	Impact	NNP
cord-000257-ampip7od	182	78	of	of	IN
cord-000257-ampip7od	182	79	taxon	taxon	NN
cord-000257-ampip7od	182	80	sampling	sampling	NN
cord-000257-ampip7od	182	81	on	on	IN
cord-000257-ampip7od	182	82	the	the	DT
cord-000257-ampip7od	182	83	estimation	estimation	NN
cord-000257-ampip7od	182	84	of	of	IN
cord-000257-ampip7od	182	85	rates	rate	NNS
cord-000257-ampip7od	182	86	of	of	IN
cord-000257-ampip7od	182	87	evolution	evolution	NN
cord-000257-ampip7od	182	88	at	at	IN
cord-000257-ampip7od	182	89	sites	site	NNS
cord-000257-ampip7od	183	1	Comparative	comparative	JJ
cord-000257-ampip7od	183	2	genomics	genomic	NNS
cord-000257-ampip7od	183	3	beyond	beyond	IN
cord-000257-ampip7od	183	4	sequence	sequence	NN
cord-000257-ampip7od	183	5	-	-	HYPH
cord-000257-ampip7od	183	6	based	base	VBN
cord-000257-ampip7od	183	7	alignments	alignment	NNS
cord-000257-ampip7od	183	8	:	:	:
cord-000257-ampip7od	184	1	RNA	RNA	NNP
cord-000257-ampip7od	184	2	structures	structure	NNS
cord-000257-ampip7od	184	3	in	in	IN
cord-000257-ampip7od	184	4	the	the	DT
cord-000257-ampip7od	184	5	ENCODE	encode	NN
cord-000257-ampip7od	184	6	regions	region	NNS
cord-000257-ampip7od	184	7	Comparative	comparative	JJ
cord-000257-ampip7od	184	8	analysis	analysis	NN
cord-000257-ampip7od	184	9	of	of	IN
cord-000257-ampip7od	184	10	splice	splice	NN
cord-000257-ampip7od	184	11	form	form	NN
cord-000257-ampip7od	184	12	-	-	HYPH
cord-000257-ampip7od	184	13	specific	specific	JJ
cord-000257-ampip7od	184	14	expression	expression	NN
cord-000257-ampip7od	184	15	of	of	IN
cord-000257-ampip7od	184	16	LIM	LIM	NNP
cord-000257-ampip7od	184	17	Kinases	Kinases	NNP
cord-000257-ampip7od	184	18	during	during	IN
cord-000257-ampip7od	184	19	zebrafish	zebrafish	NN
cord-000257-ampip7od	184	20	development	development	NN
cord-000257-ampip7od	184	21	Towards	towards	IN
cord-000257-ampip7od	184	22	cellular	cellular	JJ
cord-000257-ampip7od	184	23	systems	system	NNS
cord-000257-ampip7od	184	24	in	in	IN
cord-000257-ampip7od	184	25	4D	4D	NNP
cord-000257-ampip7od	184	26	Gene	Gene	NNP
cord-000257-ampip7od	184	27	expression	expression	NN
cord-000257-ampip7od	184	28	map	map	NN
cord-000257-ampip7od	184	29	of	of	IN
cord-000257-ampip7od	184	30	the	the	DT
cord-000257-ampip7od	184	31	Arabidopsis	Arabidopsis	NNP
cord-000257-ampip7od	184	32	shoot	shoot	VB
cord-000257-ampip7od	184	33	apical	apical	JJ
cord-000257-ampip7od	184	34	meristem	meristem	NN
cord-000257-ampip7od	184	35	stem	stem	NN
cord-000257-ampip7od	184	36	cell	cell	NN
cord-000257-ampip7od	184	37	niche	niche	NN
cord-000257-ampip7od	184	38	A	a	DT
cord-000257-ampip7od	184	39	gene	gene	NN
cord-000257-ampip7od	184	40	expression	expression	NN
cord-000257-ampip7od	184	41	map	map	NN
cord-000257-ampip7od	184	42	of	of	IN
cord-000257-ampip7od	184	43	Arabidopsis	Arabidopsis	NNP
cord-000257-ampip7od	184	44	thaliana	thaliana	NN
cord-000257-ampip7od	184	45	development	development	NN