id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349774-898tmq14	Zhang, Haiyang	Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein	2020-06-16		.txt	text/plain	3172	188	52	title: Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein Here, we report for the first time that the 11S proteasomal activator PA28γ regulates the intracellular abundance of the SARS-CoV-2 N protein (nCoV N). These results suggest that PA28γ binding is important in regulating 20S proteasome activity, which in turn regulates levels of the critical nCoV N nucleocapsid protein of SARS-CoV-2, furthering our understanding of the pathogenesis of COVID-19. The SARS-CoV-2 nucleocapsid protein (hereafter, referred to as nCoV N) accounts for the largest proportion of viral structure proteins and is the most abundant protein in virus-infected cells. PA28γ could be critical for degrading the SARS-CoV-19 nCoV N protein in the nucleus as part of the 20S proteasome, which acts to degrade proteins in a ubiquitin-independent manner, such as seen in the hepatitis C virus (HCV) core protein [11] . Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42	./cache/cord-349774-898tmq14.txt	./txt/cord-349774-898tmq14.txt