id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328483-sj8i9ss2	Jaegle, Mike	Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery	2017-05-31		.txt	text/plain	9580	543	44	Protein-templated fragment ligations are chemical reactions between small molecules ("fragments") utilizing aproteinss urface as areaction vessel to catalyzethe formation of aprotein ligand with increased binding affinity.T he approache xploits the molecular recognition of reactive small-molecule fragments by proteins both for ligand assembly and for the identification of bioactive fragment combinations.Inthis way, chemical synthesis and bioassayare integrated in one single step.T his Review discusses the biophysical basis of reversible and irreversible fragment ligations and gives an overview of the available methods to detect protein-templated ligation products.T he chemical scope and recent applications as well as future potential of the concept in drug discovery are reviewed.	./cache/cord-328483-sj8i9ss2.txt	./txt/cord-328483-sj8i9ss2.txt