id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325043-vqjhiv7p	Gorbalenya, Alexander E.	An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication	1989		.txt	text/plain	6805	361	52	title: An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication These observations, taken together with the results of comparative analysis of the positions occupied by respective proteins (domains) in viral multidomain proteins, suggest that all the NTP-motif-containing proteins of positive-strand RNA viruses are homologous, constituting a highly diverged monophyletic group. Preliminary comparative analysis of the amino acid sequences of the NTP-motif-eontaining proteins of positive-strand RNA viruses by use of the programs DIAGON and OPTAL (see Methods) revealed three distinct families and some additional proteins in whose close relatives the motif was not conserved. In the present study we demonstrate that in a highly diverged group including similar proteins of positive-strand RNA viruses, the consensus sequences of the NTP-motif constitute the most strictly conserved stretches, encompassing four of the five invariant amino acid residues.	./cache/cord-325043-vqjhiv7p.txt	./txt/cord-325043-vqjhiv7p.txt