id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316258-7hucqcaj	Henriques, Elsa S	Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus	2011-01-28		.txt	text/plain	4079	181	48	A recently identified novel ASFV viral protein (pI329L) was found to inhibit the Toll-like receptor 3 (TLR3) signaling pathway, TLR3 being a crucial "danger detector." pI329L has been predicted to be a transmembrane protein containing extracellular putative leucine-rich repeats similar to TLR3, suggesting that pI329L might act as a TLR3 decoy. As this later domain shares only remote sequence relationships with the available TLR3 templates, a more complex modeling strategy was employed that combines the iterative implementation of (multi)threading/assembly/refinement (I-TASSER) structural prediction with expertise-guided posterior refinement. On dimerization subsequent to recognition of dsRNA, TLR3 recruits the adaptor protein Toll-interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-b (TRIF) to its cytoplasmic domain, thereby initiating a signaling cascade that results in the secretion of type I interferons and other inflammatory cytokines.	./cache/cord-316258-7hucqcaj.txt	./txt/cord-316258-7hucqcaj.txt