id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314039-qkrmxvaj	Houdebine, Louis-Marie	Production of pharmaceutical proteins by transgenic animals	2008-02-19		.txt	text/plain	4773	278	47	Interestingly, genetically modified yeast expressing foreign genes coding for enzymes responsible for glycosylation proved able to secrete substantial amounts of recombinant proteins having carbohydrates almost similar to those found in human proteins [1] . Transgenic animals offer particularly attractive possibilities to prepare recombinant pharmaceutical proteins. Ruminants are potentially the most appropriate species to produce large amount of proteins but they need cloning or lentiviral vectors to integrate foreign genes, their reproduction is relatively slow, they do not glycosylate proteins as well as rabbits and pigs and they are sensitive to prion diseases (Tables 3 and 4) . The recombinant protein ATryn (human antithrombinIII) produced in goat milk contains less sialic acid than its native counterpart is a case in point [29] . The two major animal systems to produce pharmaceutical proteins in milk and egg white have recently been technically improved and their use as an essential source of new medicaments has become very likely.	./cache/cord-314039-qkrmxvaj.txt	./txt/cord-314039-qkrmxvaj.txt