id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304953-ntg8w5k4	Modis, Yorgo	Relating structure to evolution in class II viral membrane fusion proteins	2014-02-11		.txt	text/plain	3699	177	44	The striking structural similarity between the flavivirus E proteins and RVFV G -which extends to the mode of dimerization even though E and Gc dimers form different types of icosahedral lattices -is strongly suggestive of a common evolutionary origin for certain envelope proteins within the Bunyaviridae and Flaviviridae families. The conservation of an a-helical coiled coil architecture in class I viral proteins and in the SNARE family of intracellular vesicle fusion proteins provides a compelling precedent for the evolutionary transfer of a structural membrane fusion fold between host and virus during evolution. . This study showed that the Gc envelope protein from Rift Valley fever virus (from the Bunyaviridae family) has a class II fold with striking resemblances to that of E from dengue and other flaviviruses, including a propensity to form head-to-tail dimers with a hydrophobic membrane anchor, or fusion loop buried at the dimer interface.	./cache/cord-304953-ntg8w5k4.txt	./txt/cord-304953-ntg8w5k4.txt