id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302514-rstvf3mc	Abbas, Wasim	The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections	2015-04-07		.txt	text/plain	5138	283	38	Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. Overexpression of eEF1A2 protein up-regulates overall PI4K activity and cellular phosphatidylinositol 4-phosphate (PI4P) generation in human cells. In addition, high-resolution analysis of genomic aberration by metaphase and comparative genomic hybridization array identify the involvement of the 20q region, suggesting the potential role of eEF1A2 as a candidate tumor gene in lung cancer cell lines (41) . eEF1A2 interacts directly with Prx-1 and protects the cells from stress-induced apoptosis by the down-regulation of caspase-3 and caspase-8 activation parallel to increased expression of the pro-survival factor Akt (76, 77) . Elongation factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility Expression profile of eukaryotic translation factors in human cancer tissues and cell lines	./cache/cord-302514-rstvf3mc.txt	./txt/cord-302514-rstvf3mc.txt