id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296347-fanlvxqs	Loureiro, Joana	Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions	2006-12-02		.txt	text/plain	28921	1425	45	We discuss the many human cytomegalovirus (HCMV)-encoded immunomodulatory genes that interfere with antigen presentation (immunoevasins) and focus on the HCMV immunoevasins US2 and US11, which induce the degradation of class I MHC heavy chains by the proteasome by catalyzing their export from the endoplasmic reticulum (ER)-membrane into the cytosol, a process termed ER dislocation. One theme that arises from the characterization of this process over the 10 years that have passed since its discovery is that HC dislocation is unique in many respects: HC molecules do not meet the requirement of being either misfolded or misassembled, yet their dislocation takes place by virtue of the presence of US2 or US11; the speed of HC degradation is unrivaled by that of any other ER-associated degradation substrates: HC half-life is reduced from hours to a mere 2-5 min in cells infected by HCMV or in ce lls expressin g either US2 or US11 ( Wiertz et al ., 1996a ,b) ; both US2 and US11 have stringent requirements in terms of which HLA alleles (Barel et al., 2003 (Barel et al., , 2006 Machold et al., 1997) or assembly, folding and ubiquitination status of the class I MHC complex (Blom et al., 2004; Furman et al., 2003; Gewurz et al., 2001) either viral protein is able to target for dislocation and proteasomal destruction.	./cache/cord-296347-fanlvxqs.txt	./txt/cord-296347-fanlvxqs.txt