id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292688-w4zvfkyl	Tooze, Sharon A	Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells	1998-08-14		.txt	text/plain	8150	320	45	An alternative hypothesis is that there is very little constitutive secretion originating from the TGN of regulated cells, and that most molecules in the biosynthetic pathway exit into ISGs. In the ISG, the non-secretory granule proteins would presumably be sorted from the regulated secretory proteins via interaction with a receptor and removed from the ISG in constitutive-like vesicles. Depending on the cargo, distinct mechanisms could be used for selection to increase the e¤ciency of removal of nonsecretory granule proteins from the maturing ISGs. While the mechanisms involved in the formation of both constitutive and regulated secretory vesicles from the TGN is largely unknown there have been recent reports which suggest that both these budding reactions maybe unique in that they function independently of known coat proteins. In the PC12 cell assay, the same e¡ect was observed with [AlF 4 ] À and several other lines of evidence demonstrated that heterotrimeric GTP-binding proteins are involved in the regulation of post-Golgi vesicle formation (see [71] for review).	./cache/cord-292688-w4zvfkyl.txt	./txt/cord-292688-w4zvfkyl.txt