id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276456-oa6hh7ky	Collins, R.N.	5.14 The Biophysics of Membrane Fusion	2012-05-03		.txt	text/plain	9156	448	44	It will be challenging to distinguish between the lipid simply being a scaffold for a multitude of proteins involved with trafficking at the plasma membrane, and having a direct function in the bilayer rearrangements of fusion and fission. 38 The requirements for specific amino acids at certain positions and for a defined length in the fusion peptide have been further supported by the NMR-solved structure of fusion peptide in detergent micelles and in model lipid membranes 43,52 stabilized by a charge-dipole interaction between the N-terminal Gly and the dipole moment of helix 2 54 (Figure 6 ). The energetics and topology of SNARE complex formation may influence local bending of the a-helix at the interfacial region, which in turn could generate local membrane destabilization to aid fusion ( Figure 8) . How conformational changes amongst SNARE proteins and their accessory factors control the thermodynamics and kinetics of docking, lipid mixing and content mixing after membrane fusion remain open questions.	./cache/cord-276456-oa6hh7ky.txt	./txt/cord-276456-oa6hh7ky.txt