id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-243806-26n22jbx	Vandelli, Andrea	Structural analysis of SARS-CoV-2 and prediction of the human interactome	2020-03-30		.txt	text/plain	5252	317	52	Here, we performed sequence and structural alignments among 62 SARS-CoV-2 strains and identified the conservation of specific elements in the spike S region, which provides clues on the evolution of domains involved in the binding to ACE2 and sialic acid. As highly structured regions of RNA molecules have strong propensity to form stable contacts with proteins 14 and promote assembly of specific complexes 15, 16 , SARS-CoV-2 domains enriched in double-stranded content are expected to establish interactions within host cells that are important to replicate the virus 17 . Analysis of functional annotations carried out with GeneMania 46 revealed that proteins interacting with the 5' of SARS-CoV-2 RNA are associated with regulatory pathways involving NOTCH2, MYC and MAX that have been previously connected to viral infection processes ( Fig. 4E) 47, 48 .	./cache/cord-243806-26n22jbx.txt	./txt/cord-243806-26n22jbx.txt