id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-048471-7jszm1nd	Salim, Omar	Functional Analysis of the 5′ Genomic Sequence of a Bovine Norovirus	2008-05-14		.txt	text/plain	5646	246	49	Although slightly larger than predicted the N-term protein was detected in a processed form in vivo, thus not only demonstrating initial translation of the ORF1 polyprotein but also activity of the viral protease. Previous studies of norovirus polyprotein processing have yielded three major products following in vitro transcription and translation, representing the uncleaved 3ABCD, N-term and 2C proteins. In addition, this important observation also confirms for the first time that the JV 3C protease was active in cells transfected with capped RNA as the size of the V5/N-term indicated successful cleavage of the protein from the ORF1 polyprotein. Unlike similarly studied human noroviruses JV initially did not appear to express the N-terminal protein, presenting the possibility that the encoding RNA sequence had a regulatory function itself, most likely involved in translation initiation in an IRES-like manner.	./cache/cord-048471-7jszm1nd.txt	./txt/cord-048471-7jszm1nd.txt