id author title date pages extension mime words sentences flesch summary cache txt cord-021500-sy6lnt7b Jean Harry, G. Myelination, Dysmyelination, and Demyelination 2007-05-09 .txt text/plain 17601 760 37 The size of the fibers and the thickness of the sheaths are very different in the PNS and the CNS, but the overall surface area of myelin generated by an oligodendrocyte around multiple axons may be no larger than that formed by a Schwann cell around a single internode. Myelinating Schwann cells progress through a proliferative "premyelinating" stage, characterized by transient expression of suppressed cAMP-inducible Pou-domain transcription factor (SCIP), followed by a "promyelinating" GalC-positive stage, becoming associated with a single axon in the process. Members of the NDF growth factor family, including glial growth factor (GGF), heregulin, acetylcholine-inducing activity (ARIA), and neuregulin, are alternatively spliced products of a single gene, and these molecules are emerging as important regulators of Schwann cell lineage development (Dong et aL, 1995; Zorick and Lemke, 1996) . ./cache/cord-021500-sy6lnt7b.txt ./txt/cord-021500-sy6lnt7b.txt