id author title date pages extension mime words sentences flesch summary cache txt cord-324435-qpufvt3o Neufeld, Zoltan Targeted adaptive isolation strategy for COVID-19 pandemic 2020-06-05 .txt text/plain 2156 108 48 We show that an alternative or complementary approach based on targeted isolation of the vulnerable sub-population may provide a more efficient and robust strategy at a lower economic and social cost within a shorter timeframe resulting in a collectively immune population. The so called "social distancing" strategy aims to reduce social interactions within the population decreasing the probability of transmission of the infection, represented by the parameter k in the model. • if R 0 remains > 1, the social distancing can significantly extend the duration of the epidemic, making it difficult to maintain the reduced transmission rate over a long time period in a large population. To take into account the markedly different age-dependent outcome of the COVID-19 infection, we extend the standard SIR model by separating the population into two compartments: the lowrisk majority population with mild symptoms, and a vulnerable, mainly older population, where infection is more likely to lead to hospitalization and death; see Fig. 2 (a). ./cache/cord-324435-qpufvt3o.txt ./txt/cord-324435-qpufvt3o.txt