id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021816-gk8rwyq4	Weinberger, Steven E.	Pneumonia	2018-02-22		.txt	text/plain	7586	365	33	In practice, several factors frequently cause enough impairment of host defenses to contribute to the development of pneumonia, even though individuals with such impairment are not considered "immunosuppressed." Viral upper respiratory tract infections, ethanol abuse, cigarette smoking, heart failure, and preexisting chronic obstructive pulmonary disease (COPD) are a few of the contributing factors. Three major settings in which this organism is seen as a cause of pneumonia are (1) as a secondary complication of respiratory tract infection with the influenza virus; (2) in the hospitalized patient, who often has some impairment of host defense mechanisms and whose oropharynx has been colonized by Staphylococcus; and (3) as a complication of widespread dissemination of staphylococcal organisms through the bloodstream. One issue that has sparked controversy is whether an attempt should be made to identify a specific etiologic agent, using Gram stain and culture, in patients with community-acquired pneumonia, or whether empirical therapy should be used based on the patient's risk factors, clinical characteristics, and local bacterial resistance patterns.	./cache/cord-021816-gk8rwyq4.txt	./txt/cord-021816-gk8rwyq4.txt