id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322100-zkuj22oc	Mason, H. S.	Plant-Derived Antigens as Mucosal Vaccines	2011-08-03		.txt	text/plain	7965	382	43	The initial goal to immunize orally by ingestion of plant-derived antigens has proven difficult to attain, although many studies have demonstrated antibody production in both humans and animals, and in a few cases, protection against pathogen challenge. 2010 studies with mice, we have found that nasal co-delivery of t-rNV and a Toll-like receptor (TLR) agonist can produce robust systemic and mucosal antigen-specific antibody responses. Fig. 2 Induction of antigen-specific IgA at distal mucosal sites following intranasal, but not oral administration of tobacco-derived Norwalk virus-like particles (t-rNV). The first plant-derived vaccine immunogen to be tested in humans was the B subunit protein of the enterotoxigenic Escherichia coli heat-labile toxin (LT) expressed in transgenic potatoes Tacket et al. Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1	./cache/cord-322100-zkuj22oc.txt	./txt/cord-322100-zkuj22oc.txt