id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350626-ov9fy10b	Nazki, Salik	Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus	2020-05-13		.txt	text/plain	9908	427	48	At peak viremia, the frequencies of alveolar macrophages in infected pigs were significantly decreased, whereas the monocyte-derived DC/macrophage and conventional DC frequencies were increased, and these effects coincided with the early induction of local T-cell responses and the presence of proinflammatory cytokines/chemokines in the lungs, BAL, and BLN as early as 10 dpc. In this context, the present study aimed to investigate the trend of host immune responses against PRRSV infection during disease progression and to elucidate the innate and adaptive immunological mediators modulated by the PRRSV-JA142 strain both systemically in peripheral blood and locally in the bronchoalveolar lavage, lung parenchyma and bronchial lymph nodes (BLN) of infected pigs. To observe the activation of the local adaptive immune responses by innate immune cells at the sites of replication and the persistence of PRRSV, the T-cell phenotypes in the BLN, BAL and lung parenchyma of the euthanized control and infected pigs were analysed at 10, 21, 28 and 35 dpc.	./cache/cord-350626-ov9fy10b.txt	./txt/cord-350626-ov9fy10b.txt