id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261925-nsq837z1	Denner, Joachim	Preventing transfer of infectious agents	2015-08-24		.txt	text/plain	4308	222	38	Xenotransplantation using pig cells, tissues and organs may be associated with the transfer of porcine infectious agents, which may infect the human recipient and in the worst case induce a disease (zoonosis). To prevent this, a broad screening program of the donor animals for putative zoonotic microorganisms, including bacteria, viruses, fungi and others, using sensitive and specific detection methods has to be performed. In the case of porcine endogenous retroviruses (PERVs) which are integrated in the genome of all pigs and which cannot be eliminated this way, selection of animals with low virus expression and generation of genetically modified pigs suppressing PERV expressions may be performed. At the moment hepatitis E virus (HEV), porcine cytomegalovirus (PCMV), porcine circoviruses (PCV), porcine lymphotropic herpes viruses (PLHV), and porcine endogenous retroviruses (PERVs) are thought to pose the main risk for reasons to be discussed below and therefore these microorganisms will be analysed in the next chapters in more details.	./cache/cord-261925-nsq837z1.txt	./txt/cord-261925-nsq837z1.txt