id	sid	tid	token	lemma	pos
cord-343791-0vykwml5	1	1	key	key	NN
cord-343791-0vykwml5	1	2	:	:	:
cord-343791-0vykwml5	2	1	cord-343791	cord-343791	NNP
cord-343791-0vykwml5	2	2	-	-	HYPH
cord-343791-0vykwml5	2	3	0vykwml5	0vykwml5	CD
cord-343791-0vykwml5	2	4	authors	author	NNS
cord-343791-0vykwml5	2	5	:	:	:
cord-343791-0vykwml5	2	6	Hainline	Hainline	NNP
cord-343791-0vykwml5	2	7	,	,	,
cord-343791-0vykwml5	2	8	Kelly	Kelly	NNP
cord-343791-0vykwml5	2	9	M.	M.	NNP
cord-343791-0vykwml5	2	10	;	;	:
cord-343791-0vykwml5	2	11	Fries	Fries	NNP
cord-343791-0vykwml5	2	12	,	,	,
cord-343791-0vykwml5	2	13	Chelsea	Chelsea	NNP
cord-343791-0vykwml5	2	14	N.	N.	NNP
cord-343791-0vykwml5	2	15	;	;	:
cord-343791-0vykwml5	2	16	Collier	Collier	NNP
cord-343791-0vykwml5	2	17	,	,	,
cord-343791-0vykwml5	2	18	Joel	Joel	NNP
cord-343791-0vykwml5	2	19	H.	H.	NNP
cord-343791-0vykwml5	3	1	title	title	NN
cord-343791-0vykwml5	3	2	:	:	:
cord-343791-0vykwml5	3	3	Progress	progress	VB
cord-343791-0vykwml5	3	4	towards	towards	IN
cord-343791-0vykwml5	3	5	the	the	DT
cord-343791-0vykwml5	3	6	clinical	clinical	JJ
cord-343791-0vykwml5	3	7	translation	translation	NN
cord-343791-0vykwml5	3	8	of	of	IN
cord-343791-0vykwml5	3	9	bio	bio	JJ
cord-343791-0vykwml5	3	10	-	-	HYPH
cord-343791-0vykwml5	3	11	inspired	inspire	VBN
cord-343791-0vykwml5	3	12	peptide	peptide	NN
cord-343791-0vykwml5	3	13	and	and	CC
cord-343791-0vykwml5	3	14	protein	protein	NN
cord-343791-0vykwml5	3	15	assemblies	assembly	NNS
cord-343791-0vykwml5	3	16	date	date	NN
cord-343791-0vykwml5	3	17	:	:	:
cord-343791-0vykwml5	3	18	2017	2017	CD
cord-343791-0vykwml5	3	19	-	-	HYPH
cord-343791-0vykwml5	3	20	11	11	CD
cord-343791-0vykwml5	3	21	-	-	HYPH
cord-343791-0vykwml5	3	22	08	08	CD
cord-343791-0vykwml5	3	23	journal	journal	NN
cord-343791-0vykwml5	3	24	:	:	:
cord-343791-0vykwml5	4	1	Advanced	Advanced	NNP
cord-343791-0vykwml5	4	2	Healthcare	Healthcare	NNP
cord-343791-0vykwml5	4	3	Materials	Materials	NNPS
cord-343791-0vykwml5	4	4	DOI	DOI	NNP
cord-343791-0vykwml5	4	5	:	:	:
cord-343791-0vykwml5	5	1	10.1002	10.1002	CD
cord-343791-0vykwml5	5	2	/	/	SYM
cord-343791-0vykwml5	5	3	adhm.201700930	adhm.201700930	NNP
cord-343791-0vykwml5	5	4	sha	sha	NNP
cord-343791-0vykwml5	5	5	:	:	:
cord-343791-0vykwml5	6	1	7aaf47fc90f9db6e22d4afa90e35f49be174ffa3	7aaf47fc90f9db6e22d4afa90e35f49be174ffa3	CD
cord-343791-0vykwml5	6	2	doc_id	doc_id	CD
cord-343791-0vykwml5	6	3	:	:	:
cord-343791-0vykwml5	6	4	343791	343791	CD
cord-343791-0vykwml5	6	5	cord_uid	cord_uid	NNS
cord-343791-0vykwml5	6	6	:	:	:
cord-343791-0vykwml5	7	1	0vykwml5	0vykwml5	CD
cord-343791-0vykwml5	8	1	Supramolecular	supramolecular	JJ
cord-343791-0vykwml5	8	2	materials	material	NNS
cord-343791-0vykwml5	8	3	composed	compose	VBN
cord-343791-0vykwml5	8	4	of	of	IN
cord-343791-0vykwml5	8	5	proteins	protein	NNS
cord-343791-0vykwml5	8	6	and	and	CC
cord-343791-0vykwml5	8	7	peptides	peptide	NNS
cord-343791-0vykwml5	8	8	have	have	VBP
cord-343791-0vykwml5	8	9	been	be	VBN
cord-343791-0vykwml5	8	10	receiving	receive	VBG
cord-343791-0vykwml5	8	11	considerable	considerable	JJ
cord-343791-0vykwml5	8	12	attention	attention	NN
cord-343791-0vykwml5	8	13	towards	towards	IN
cord-343791-0vykwml5	8	14	a	a	DT
cord-343791-0vykwml5	8	15	range	range	NN
cord-343791-0vykwml5	8	16	of	of	IN
cord-343791-0vykwml5	8	17	diseases	disease	NNS
cord-343791-0vykwml5	8	18	and	and	CC
cord-343791-0vykwml5	8	19	conditions	condition	NNS
cord-343791-0vykwml5	8	20	from	from	IN
cord-343791-0vykwml5	8	21	vaccines	vaccine	NNS
cord-343791-0vykwml5	8	22	to	to	IN
cord-343791-0vykwml5	8	23	drug	drug	NN
cord-343791-0vykwml5	8	24	delivery	delivery	NN
cord-343791-0vykwml5	8	25	.	.	.
cord-343791-0vykwml5	9	1	Owing	owe	VBG
cord-343791-0vykwml5	9	2	to	to	IN
cord-343791-0vykwml5	9	3	the	the	DT
cord-343791-0vykwml5	9	4	relative	relative	JJ
cord-343791-0vykwml5	9	5	newness	newness	NN
cord-343791-0vykwml5	9	6	of	of	IN
cord-343791-0vykwml5	9	7	this	this	DT
cord-343791-0vykwml5	9	8	class	class	NN
cord-343791-0vykwml5	9	9	of	of	IN
cord-343791-0vykwml5	9	10	materials	material	NNS
cord-343791-0vykwml5	9	11	,	,	,
cord-343791-0vykwml5	9	12	the	the	DT
cord-343791-0vykwml5	9	13	bulk	bulk	NN
cord-343791-0vykwml5	9	14	of	of	IN
cord-343791-0vykwml5	9	15	work	work	NN
cord-343791-0vykwml5	9	16	to	to	IN
cord-343791-0vykwml5	9	17	date	date	NN
cord-343791-0vykwml5	9	18	has	have	VBZ
cord-343791-0vykwml5	9	19	been	be	VBN
cord-343791-0vykwml5	9	20	preclinical	preclinical	JJ
cord-343791-0vykwml5	9	21	.	.	.
cord-343791-0vykwml5	10	1	However	however	RB
cord-343791-0vykwml5	10	2	,	,	,
cord-343791-0vykwml5	10	3	examples	example	NNS
cord-343791-0vykwml5	10	4	of	of	IN
cord-343791-0vykwml5	10	5	approved	approve	VBN
cord-343791-0vykwml5	10	6	treatments	treatment	NNS
cord-343791-0vykwml5	10	7	particularly	particularly	RB
cord-343791-0vykwml5	10	8	in	in	IN
cord-343791-0vykwml5	10	9	vaccines	vaccine	NNS
cord-343791-0vykwml5	10	10	,	,	,
cord-343791-0vykwml5	10	11	dentistry	dentistry	NN
cord-343791-0vykwml5	10	12	,	,	,
cord-343791-0vykwml5	10	13	and	and	CC
cord-343791-0vykwml5	10	14	hemostasis	hemostasis	NN
cord-343791-0vykwml5	10	15	are	be	VBP
cord-343791-0vykwml5	10	16	demonstrating	demonstrate	VBG
cord-343791-0vykwml5	10	17	the	the	DT
cord-343791-0vykwml5	10	18	translational	translational	JJ
cord-343791-0vykwml5	10	19	potential	potential	NN
cord-343791-0vykwml5	10	20	of	of	IN
cord-343791-0vykwml5	10	21	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	10	22	polypeptides	polypeptide	NNS
cord-343791-0vykwml5	10	23	.	.	.
cord-343791-0vykwml5	11	1	Here	here	RB
cord-343791-0vykwml5	11	2	we	-PRON-	PRP
cord-343791-0vykwml5	11	3	describe	describe	VBP
cord-343791-0vykwml5	11	4	critical	critical	JJ
cord-343791-0vykwml5	11	5	milestones	milestone	NNS
cord-343791-0vykwml5	11	6	in	in	IN
cord-343791-0vykwml5	11	7	the	the	DT
cord-343791-0vykwml5	11	8	clinical	clinical	JJ
cord-343791-0vykwml5	11	9	development	development	NN
cord-343791-0vykwml5	11	10	of	of	IN
cord-343791-0vykwml5	11	11	this	this	DT
cord-343791-0vykwml5	11	12	class	class	NN
cord-343791-0vykwml5	11	13	of	of	IN
cord-343791-0vykwml5	11	14	materials	material	NNS
cord-343791-0vykwml5	11	15	and	and	CC
cord-343791-0vykwml5	11	16	describe	describe	VBP
cord-343791-0vykwml5	11	17	currently	currently	RB
cord-343791-0vykwml5	11	18	approved	approve	VBN
cord-343791-0vykwml5	11	19	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	11	20	polypeptide	polypeptide	NN
cord-343791-0vykwml5	11	21	therapies	therapy	NNS
cord-343791-0vykwml5	11	22	.	.	.
cord-343791-0vykwml5	12	1	Additional	additional	JJ
cord-343791-0vykwml5	12	2	examples	example	NNS
cord-343791-0vykwml5	12	3	of	of	IN
cord-343791-0vykwml5	12	4	not	not	RB
cord-343791-0vykwml5	12	5	-	-	HYPH
cord-343791-0vykwml5	12	6	yet	yet	RB
cord-343791-0vykwml5	12	7	-	-	HYPH
cord-343791-0vykwml5	12	8	approved	approve	VBN
cord-343791-0vykwml5	12	9	materials	material	NNS
cord-343791-0vykwml5	12	10	that	that	WDT
cord-343791-0vykwml5	12	11	are	be	VBP
cord-343791-0vykwml5	12	12	steadily	steadily	RB
cord-343791-0vykwml5	12	13	advancing	advance	VBG
cord-343791-0vykwml5	12	14	towards	towards	IN
cord-343791-0vykwml5	12	15	clinical	clinical	JJ
cord-343791-0vykwml5	12	16	use	use	NN
cord-343791-0vykwml5	12	17	are	be	VBP
cord-343791-0vykwml5	12	18	also	also	RB
cord-343791-0vykwml5	12	19	featured	feature	VBN
cord-343791-0vykwml5	12	20	.	.	.
cord-343791-0vykwml5	13	1	Spherical	spherical	JJ
cord-343791-0vykwml5	13	2	assemblies	assembly	NNS
cord-343791-0vykwml5	13	3	such	such	JJ
cord-343791-0vykwml5	13	4	as	as	IN
cord-343791-0vykwml5	13	5	virus	virus	NN
cord-343791-0vykwml5	13	6	-	-	HYPH
cord-343791-0vykwml5	13	7	like	like	JJ
cord-343791-0vykwml5	13	8	particles	particle	NNS
cord-343791-0vykwml5	13	9	(	(	-LRB-
cord-343791-0vykwml5	13	10	VLPs	VLPs	NNP
cord-343791-0vykwml5	13	11	)	)	-RRB-
cord-343791-0vykwml5	13	12	,	,	,
cord-343791-0vykwml5	13	13	designed	design	VBN
cord-343791-0vykwml5	13	14	protein	protein	NN
cord-343791-0vykwml5	13	15	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	13	16	,	,	,
cord-343791-0vykwml5	13	17	and	and	CC
cord-343791-0vykwml5	13	18	spherical	spherical	JJ
cord-343791-0vykwml5	13	19	peptide	peptide	NN
cord-343791-0vykwml5	13	20	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	13	21	are	be	VBP
cord-343791-0vykwml5	13	22	highlighted	highlight	VBN
cord-343791-0vykwml5	13	23	,	,	,
cord-343791-0vykwml5	13	24	followed	follow	VBN
cord-343791-0vykwml5	13	25	by	by	IN
cord-343791-0vykwml5	13	26	fiber	fiber	NN
cord-343791-0vykwml5	13	27	-	-	HYPH
cord-343791-0vykwml5	13	28	forming	form	VBG
cord-343791-0vykwml5	13	29	systems	system	NNS
cord-343791-0vykwml5	13	30	such	such	JJ
cord-343791-0vykwml5	13	31	as	as	IN
cord-343791-0vykwml5	13	32	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	13	33	peptides	peptide	NNS
cord-343791-0vykwml5	13	34	,	,	,
cord-343791-0vykwml5	13	35	fiber	fiber	NN
cord-343791-0vykwml5	13	36	-	-	HYPH
cord-343791-0vykwml5	13	37	forming	form	VBG
cord-343791-0vykwml5	13	38	peptide	peptide	NN
cord-343791-0vykwml5	13	39	-	-	HYPH
cord-343791-0vykwml5	13	40	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	13	41	,	,	,
cord-343791-0vykwml5	13	42	and	and	CC
cord-343791-0vykwml5	13	43	filamentous	filamentous	JJ
cord-343791-0vykwml5	13	44	bacteriophages	bacteriophage	NNS
cord-343791-0vykwml5	13	45	.	.	.
cord-343791-0vykwml5	14	1	finding	find	VBG
cord-343791-0vykwml5	14	2	utilization	utilization	NN
cord-343791-0vykwml5	14	3	in	in	IN
cord-343791-0vykwml5	14	4	biomedical	biomedical	JJ
cord-343791-0vykwml5	14	5	applications	application	NNS
cord-343791-0vykwml5	14	6	ranging	range	VBG
cord-343791-0vykwml5	14	7	between	between	IN
cord-343791-0vykwml5	14	8	immunomodulation	immunomodulation	NN
cord-343791-0vykwml5	14	9	,	,	,
cord-343791-0vykwml5	14	10	drug	drug	NN
cord-343791-0vykwml5	14	11	delivery	delivery	NN
cord-343791-0vykwml5	14	12	,	,	,
cord-343791-0vykwml5	14	13	tissue	tissue	NN
cord-343791-0vykwml5	14	14	regeneration	regeneration	NN
cord-343791-0vykwml5	14	15	,	,	,
cord-343791-0vykwml5	14	16	defect	defect	NN
cord-343791-0vykwml5	14	17	repair	repair	NN
cord-343791-0vykwml5	14	18	,	,	,
cord-343791-0vykwml5	14	19	cell	cell	NN
cord-343791-0vykwml5	14	20	delivery	delivery	NN
cord-343791-0vykwml5	14	21	,	,	,
cord-343791-0vykwml5	14	22	and	and	CC
cord-343791-0vykwml5	14	23	combinations	combination	NNS
cord-343791-0vykwml5	14	24	thereof	thereof	RB
cord-343791-0vykwml5	14	25	.	.	.
cord-343791-0vykwml5	15	1	Many	many	JJ
cord-343791-0vykwml5	15	2	self	self	NN
cord-343791-0vykwml5	15	3	-	-	HYPH
cord-343791-0vykwml5	15	4	assembling	assemble	VBG
cord-343791-0vykwml5	15	5	systems	system	NNS
cord-343791-0vykwml5	15	6	have	have	VBP
cord-343791-0vykwml5	15	7	been	be	VBN
cord-343791-0vykwml5	15	8	investigated	investigate	VBN
cord-343791-0vykwml5	15	9	in	in	IN
cord-343791-0vykwml5	15	10	preclinical	preclinical	JJ
cord-343791-0vykwml5	15	11	research	research	NN
cord-343791-0vykwml5	15	12	,	,	,
cord-343791-0vykwml5	15	13	but	but	CC
cord-343791-0vykwml5	15	14	among	among	IN
cord-343791-0vykwml5	15	15	these	these	DT
cord-343791-0vykwml5	15	16	,	,	,
cord-343791-0vykwml5	15	17	relatively	relatively	RB
cord-343791-0vykwml5	15	18	few	few	JJ
cord-343791-0vykwml5	15	19	have	have	VBP
cord-343791-0vykwml5	15	20	been	be	VBN
cord-343791-0vykwml5	15	21	successfully	successfully	RB
cord-343791-0vykwml5	15	22	translated	translate	VBN
cord-343791-0vykwml5	15	23	into	into	IN
cord-343791-0vykwml5	15	24	approved	approved	JJ
cord-343791-0vykwml5	15	25	devices	device	NNS
cord-343791-0vykwml5	15	26	and	and	CC
cord-343791-0vykwml5	15	27	therapeutics	therapeutic	NNS
cord-343791-0vykwml5	15	28	.	.	.
cord-343791-0vykwml5	16	1	Those	those	DT
cord-343791-0vykwml5	16	2	that	that	WDT
cord-343791-0vykwml5	16	3	are	be	VBP
cord-343791-0vykwml5	16	4	in	in	IN
cord-343791-0vykwml5	16	5	current	current	JJ
cord-343791-0vykwml5	16	6	clinical	clinical	JJ
cord-343791-0vykwml5	16	7	use	use	NN
cord-343791-0vykwml5	16	8	tend	tend	VBP
cord-343791-0vykwml5	16	9	to	to	TO
cord-343791-0vykwml5	16	10	possess	possess	VB
cord-343791-0vykwml5	16	11	the	the	DT
cord-343791-0vykwml5	16	12	following	follow	VBG
cord-343791-0vykwml5	16	13	features	feature	NNS
cord-343791-0vykwml5	16	14	that	that	WDT
cord-343791-0vykwml5	16	15	have	have	VBP
cord-343791-0vykwml5	16	16	enabled	enable	VBN
cord-343791-0vykwml5	16	17	their	-PRON-	PRP$
cord-343791-0vykwml5	16	18	success	success	NN
cord-343791-0vykwml5	16	19	:	:	:
cord-343791-0vykwml5	17	1	-Chemical	-chemical	JJ
cord-343791-0vykwml5	18	1	definition	definition	NN
cord-343791-0vykwml5	18	2	-	-	:
cord-343791-0vykwml5	18	3	Highly	highly	RB
cord-343791-0vykwml5	18	4	specified	specify	VBN
cord-343791-0vykwml5	18	5	control	control	NN
cord-343791-0vykwml5	18	6	over	over	IN
cord-343791-0vykwml5	18	7	material	material	NN
cord-343791-0vykwml5	18	8	composition	composition	NN
cord-343791-0vykwml5	18	9	,	,	,
cord-343791-0vykwml5	18	10	assembly	assembly	NN
cord-343791-0vykwml5	18	11	properties	property	NNS
cord-343791-0vykwml5	18	12	,	,	,
cord-343791-0vykwml5	18	13	and	and	CC
cord-343791-0vykwml5	18	14	bioactivity	bioactivity	NN
cord-343791-0vykwml5	18	15	,	,	,
cord-343791-0vykwml5	18	16	in	in	IN
cord-343791-0vykwml5	18	17	contrast	contrast	NN
cord-343791-0vykwml5	18	18	with	with	IN
cord-343791-0vykwml5	18	19	biologically	biologically	RB
cord-343791-0vykwml5	18	20	sourced	source	VBN
cord-343791-0vykwml5	18	21	materials	material	NNS
cord-343791-0vykwml5	19	1	-Manufacturability	-Manufacturability	NNP
cord-343791-0vykwml5	20	1	-The	-The	:
cord-343791-0vykwml5	20	2	extent	extent	NN
cord-343791-0vykwml5	20	3	to	to	TO
cord-343791-0vykwml5	20	4	which	which	WDT
cord-343791-0vykwml5	20	5	the	the	DT
cord-343791-0vykwml5	20	6	platform	platform	NN
cord-343791-0vykwml5	20	7	can	can	MD
cord-343791-0vykwml5	20	8	be	be	VB
cord-343791-0vykwml5	20	9	manufactured	manufacture	VBN
cord-343791-0vykwml5	20	10	with	with	IN
cord-343791-0vykwml5	20	11	relative	relative	JJ
cord-343791-0vykwml5	20	12	ease	ease	NN
cord-343791-0vykwml5	20	13	at	at	IN
cord-343791-0vykwml5	20	14	minimum	minimum	JJ
cord-343791-0vykwml5	20	15	cost	cost	NN
cord-343791-0vykwml5	20	16	and	and	CC
cord-343791-0vykwml5	20	17	with	with	IN
cord-343791-0vykwml5	20	18	maximum	maximum	JJ
cord-343791-0vykwml5	20	19	reproducibility	reproducibility	NN
cord-343791-0vykwml5	20	20	-Tunability	-tunability	NN
cord-343791-0vykwml5	20	21	-	-	:
cord-343791-0vykwml5	20	22	The	the	DT
cord-343791-0vykwml5	20	23	ability	ability	NN
cord-343791-0vykwml5	20	24	to	to	TO
cord-343791-0vykwml5	20	25	adjust	adjust	VB
cord-343791-0vykwml5	20	26	the	the	DT
cord-343791-0vykwml5	20	27	amount	amount	NN
cord-343791-0vykwml5	20	28	of	of	IN
cord-343791-0vykwml5	20	29	multiple	multiple	JJ
cord-343791-0vykwml5	20	30	selected	selected	JJ
cord-343791-0vykwml5	20	31	active	active	JJ
cord-343791-0vykwml5	20	32	components	component	NNS
cord-343791-0vykwml5	20	33	in	in	IN
cord-343791-0vykwml5	20	34	a	a	DT
cord-343791-0vykwml5	20	35	material	material	NN
cord-343791-0vykwml5	20	36	with	with	IN
cord-343791-0vykwml5	20	37	precision	precision	NN
cord-343791-0vykwml5	20	38	and	and	CC
cord-343791-0vykwml5	20	39	reproducibility	reproducibility	NN
cord-343791-0vykwml5	20	40	.	.	.
cord-343791-0vykwml5	21	1	Synthetic	synthetic	JJ
cord-343791-0vykwml5	21	2	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	21	3	systems	system	NNS
cord-343791-0vykwml5	21	4	tend	tend	VBP
cord-343791-0vykwml5	21	5	to	to	TO
cord-343791-0vykwml5	21	6	feature	feature	VB
cord-343791-0vykwml5	21	7	this	this	DT
cord-343791-0vykwml5	21	8	property	property	NN
cord-343791-0vykwml5	21	9	well	well	RB
cord-343791-0vykwml5	21	10	beyond	beyond	IN
cord-343791-0vykwml5	21	11	naturally	naturally	RB
cord-343791-0vykwml5	21	12	derived	derive	VBN
cord-343791-0vykwml5	21	13	materials	material	NNS
cord-343791-0vykwml5	21	14	.	.	.
cord-343791-0vykwml5	22	1	Selected	select	VBN
cord-343791-0vykwml5	22	2	platforms	platform	NNS
cord-343791-0vykwml5	22	3	are	be	VBP
cord-343791-0vykwml5	22	4	discussed	discuss	VBN
cord-343791-0vykwml5	22	5	based	base	VBN
cord-343791-0vykwml5	22	6	on	on	IN
cord-343791-0vykwml5	22	7	these	these	DT
cord-343791-0vykwml5	22	8	features	feature	NNS
cord-343791-0vykwml5	22	9	,	,	,
cord-343791-0vykwml5	22	10	because	because	IN
cord-343791-0vykwml5	22	11	they	-PRON-	PRP
cord-343791-0vykwml5	22	12	have	have	VBP
cord-343791-0vykwml5	22	13	had	have	VBN
cord-343791-0vykwml5	22	14	a	a	DT
cord-343791-0vykwml5	22	15	meaningful	meaningful	JJ
cord-343791-0vykwml5	22	16	translation	translation	NN
cord-343791-0vykwml5	22	17	into	into	IN
cord-343791-0vykwml5	22	18	clinical	clinical	JJ
cord-343791-0vykwml5	22	19	practice	practice	NN
cord-343791-0vykwml5	22	20	,	,	,
cord-343791-0vykwml5	22	21	or	or	CC
cord-343791-0vykwml5	22	22	because	because	IN
cord-343791-0vykwml5	22	23	they	-PRON-	PRP
cord-343791-0vykwml5	22	24	have	have	VBP
cord-343791-0vykwml5	22	25	had	have	VBN
cord-343791-0vykwml5	22	26	steady	steady	JJ
cord-343791-0vykwml5	22	27	progress	progress	NN
cord-343791-0vykwml5	22	28	toward	toward	IN
cord-343791-0vykwml5	22	29	clinical	clinical	JJ
cord-343791-0vykwml5	22	30	translation	translation	NN
cord-343791-0vykwml5	22	31	.	.	.
cord-343791-0vykwml5	23	1	These	these	DT
cord-343791-0vykwml5	23	2	include	include	VBP
cord-343791-0vykwml5	23	3	spherical	spherical	JJ
cord-343791-0vykwml5	23	4	assemblies	assembly	NNS
cord-343791-0vykwml5	23	5	such	such	JJ
cord-343791-0vykwml5	23	6	as	as	IN
cord-343791-0vykwml5	23	7	virus	virus	NN
cord-343791-0vykwml5	23	8	-	-	HYPH
cord-343791-0vykwml5	23	9	like	like	JJ
cord-343791-0vykwml5	23	10	particles	particle	NNS
cord-343791-0vykwml5	23	11	,	,	,
cord-343791-0vykwml5	23	12	designed	design	VBN
cord-343791-0vykwml5	23	13	protein	protein	NN
cord-343791-0vykwml5	23	14	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	23	15	,	,	,
cord-343791-0vykwml5	23	16	and	and	CC
cord-343791-0vykwml5	23	17	peptide	peptide	NN
cord-343791-0vykwml5	23	18	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	23	19	(	(	-LRB-
cord-343791-0vykwml5	23	20	Figure	figure	NN
cord-343791-0vykwml5	23	21	1	1	CD
cord-343791-0vykwml5	23	22	)	)	-RRB-
cord-343791-0vykwml5	23	23	;	;	:
cord-343791-0vykwml5	23	24	and	and	CC
cord-343791-0vykwml5	23	25	elongated	elongated	JJ
cord-343791-0vykwml5	23	26	structures	structure	NNS
cord-343791-0vykwml5	23	27	such	such	JJ
cord-343791-0vykwml5	23	28	as	as	IN
cord-343791-0vykwml5	23	29	β	β	NN
cord-343791-0vykwml5	23	30	-	-	HYPH
cord-343791-0vykwml5	23	31	sheet	sheet	NN
cord-343791-0vykwml5	23	32	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	23	33	,	,	,
cord-343791-0vykwml5	23	34	fiber	fiber	NN
cord-343791-0vykwml5	23	35	-	-	HYPH
cord-343791-0vykwml5	23	36	forming	form	VBG
cord-343791-0vykwml5	23	37	peptide	peptide	JJ
cord-343791-0vykwml5	23	38	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	23	39	,	,	,
cord-343791-0vykwml5	23	40	and	and	CC
cord-343791-0vykwml5	23	41	filamentous	filamentous	JJ
cord-343791-0vykwml5	23	42	phage	phage	NN
cord-343791-0vykwml5	24	1	(	(	-LRB-
cord-343791-0vykwml5	24	2	Figure	figure	NN
cord-343791-0vykwml5	24	3	2	2	CD
cord-343791-0vykwml5	24	4	)	)	-RRB-
cord-343791-0vykwml5	24	5	.	.	.
cord-343791-0vykwml5	25	1	A	a	DT
cord-343791-0vykwml5	25	2	timeline	timeline	NN
cord-343791-0vykwml5	25	3	of	of	IN
cord-343791-0vykwml5	25	4	their	-PRON-	PRP$
cord-343791-0vykwml5	25	5	development	development	NN
cord-343791-0vykwml5	25	6	is	be	VBZ
cord-343791-0vykwml5	25	7	shown	show	VBN
cord-343791-0vykwml5	25	8	in	in	IN
cord-343791-0vykwml5	25	9	Figure	Figure	NNP
cord-343791-0vykwml5	25	10	3	3	CD
cord-343791-0vykwml5	25	11	.	.	.
cord-343791-0vykwml5	26	1	Some	some	DT
cord-343791-0vykwml5	26	2	of	of	IN
cord-343791-0vykwml5	26	3	the	the	DT
cord-343791-0vykwml5	26	4	first	first	JJ
cord-343791-0vykwml5	26	5	engineered	engineer	VBN
cord-343791-0vykwml5	26	6	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	26	7	structures	structure	NNS
cord-343791-0vykwml5	26	8	to	to	TO
cord-343791-0vykwml5	26	9	be	be	VB
cord-343791-0vykwml5	26	10	translated	translate	VBN
cord-343791-0vykwml5	26	11	effectively	effectively	RB
cord-343791-0vykwml5	26	12	have	have	VB
cord-343791-0vykwml5	26	13	been	be	VBN
cord-343791-0vykwml5	26	14	virus	virus	NN
cord-343791-0vykwml5	26	15	-	-	HYPH
cord-343791-0vykwml5	26	16	like	like	JJ
cord-343791-0vykwml5	26	17	particles	particle	NNS
cord-343791-0vykwml5	26	18	(	(	-LRB-
cord-343791-0vykwml5	26	19	VLPs	VLPs	NNP
cord-343791-0vykwml5	26	20	)	)	-RRB-
cord-343791-0vykwml5	26	21	,	,	,
cord-343791-0vykwml5	26	22	multiprotein	multiprotein	NNP
cord-343791-0vykwml5	26	23	constructs	construct	VBZ
cord-343791-0vykwml5	26	24	that	that	IN
cord-343791-0vykwml5	26	25	self	self	NN
cord-343791-0vykwml5	26	26	-	-	HYPH
cord-343791-0vykwml5	26	27	assemble	assemble	VBP
cord-343791-0vykwml5	26	28	to	to	TO
cord-343791-0vykwml5	26	29	mimic	mimic	VB
cord-343791-0vykwml5	26	30	the	the	DT
cord-343791-0vykwml5	26	31	organization	organization	NN
cord-343791-0vykwml5	26	32	,	,	,
cord-343791-0vykwml5	26	33	structure	structure	NN
cord-343791-0vykwml5	26	34	,	,	,
cord-343791-0vykwml5	26	35	and	and	CC
cord-343791-0vykwml5	26	36	immunogenicity	immunogenicity	NN
cord-343791-0vykwml5	26	37	of	of	IN
cord-343791-0vykwml5	26	38	native	native	JJ
cord-343791-0vykwml5	26	39	viruses	virus	NNS
cord-343791-0vykwml5	26	40	but	but	CC
cord-343791-0vykwml5	26	41	that	that	DT
cord-343791-0vykwml5	26	42	lack	lack	VBP
cord-343791-0vykwml5	26	43	infectious	infectious	JJ
cord-343791-0vykwml5	26	44	genetic	genetic	JJ
cord-343791-0vykwml5	26	45	materials	material	NNS
cord-343791-0vykwml5	26	46	(	(	-LRB-
cord-343791-0vykwml5	26	47	Figure	figure	NN
cord-343791-0vykwml5	26	48	1A	1a	NN
cord-343791-0vykwml5	26	49	)	)	-RRB-
cord-343791-0vykwml5	26	50	.	.	.
cord-343791-0vykwml5	27	1	[	[	-LRB-
cord-343791-0vykwml5	27	2	7	7	CD
cord-343791-0vykwml5	27	3	,	,	,
cord-343791-0vykwml5	27	4	8	8	CD
cord-343791-0vykwml5	27	5	]	]	-RRB-
cord-343791-0vykwml5	27	6	Their	-PRON-	PRP$
cord-343791-0vykwml5	27	7	development	development	NN
cord-343791-0vykwml5	27	8	has	have	VBZ
cord-343791-0vykwml5	27	9	preceded	precede	VBN
cord-343791-0vykwml5	27	10	other	other	JJ
cord-343791-0vykwml5	27	11	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	27	12	materials	material	NNS
cord-343791-0vykwml5	27	13	discussed	discuss	VBN
cord-343791-0vykwml5	27	14	here	here	RB
cord-343791-0vykwml5	27	15	(	(	-LRB-
cord-343791-0vykwml5	27	16	see	see	VB
cord-343791-0vykwml5	27	17	timeline	timeline	NN
cord-343791-0vykwml5	27	18	in	in	IN
cord-343791-0vykwml5	27	19	Figure	Figure	NNP
cord-343791-0vykwml5	27	20	3	3	CD
cord-343791-0vykwml5	27	21	)	)	-RRB-
cord-343791-0vykwml5	27	22	.	.	.
cord-343791-0vykwml5	28	1	VLPs	vlp	NNS
cord-343791-0vykwml5	28	2	are	be	VBP
cord-343791-0vykwml5	28	3	potent	potent	JJ
cord-343791-0vykwml5	28	4	immunogens	immunogen	NNS
cord-343791-0vykwml5	28	5	,	,	,
cord-343791-0vykwml5	28	6	able	able	JJ
cord-343791-0vykwml5	28	7	to	to	TO
cord-343791-0vykwml5	28	8	stimulate	stimulate	VB
cord-343791-0vykwml5	28	9	B	B	NNP
cord-343791-0vykwml5	28	10	cell	cell	NN
cord-343791-0vykwml5	28	11	/	/	SYM
cord-343791-0vykwml5	28	12	antibody	antibody	NN
cord-343791-0vykwml5	28	13	responses	response	NNS
cord-343791-0vykwml5	28	14	,	,	,
cord-343791-0vykwml5	28	15	CD4	CD4	NNP
cord-343791-0vykwml5	28	16	+	+	CC
cord-343791-0vykwml5	28	17	T	t	NN
cord-343791-0vykwml5	28	18	-	-	HYPH
cord-343791-0vykwml5	28	19	cell	cell	NN
cord-343791-0vykwml5	28	20	responses	response	NNS
cord-343791-0vykwml5	28	21	,	,	,
cord-343791-0vykwml5	28	22	and	and	CC
cord-343791-0vykwml5	28	23	cytotoxic	cytotoxic	JJ
cord-343791-0vykwml5	28	24	T	t	NN
cord-343791-0vykwml5	28	25	-	-	HYPH
cord-343791-0vykwml5	28	26	cell	cell	NN
cord-343791-0vykwml5	28	27	responses	response	NNS
cord-343791-0vykwml5	28	28	.	.	.
cord-343791-0vykwml5	29	1	[	[	-LRB-
cord-343791-0vykwml5	29	2	17	17	CD
cord-343791-0vykwml5	29	3	,	,	,
cord-343791-0vykwml5	29	4	18	18	CD
cord-343791-0vykwml5	29	5	]	]	-RRB-
cord-343791-0vykwml5	30	1	Owing	owe	VBG
cord-343791-0vykwml5	30	2	to	to	IN
cord-343791-0vykwml5	30	3	their	-PRON-	PRP$
cord-343791-0vykwml5	30	4	lack	lack	NN
cord-343791-0vykwml5	30	5	of	of	IN
cord-343791-0vykwml5	30	6	a	a	DT
cord-343791-0vykwml5	30	7	viral	viral	JJ
cord-343791-0vykwml5	30	8	genome	genome	NN
cord-343791-0vykwml5	30	9	,	,	,
cord-343791-0vykwml5	30	10	VLP	VLP	NNP
cord-343791-0vykwml5	30	11	-	-	HYPH
cord-343791-0vykwml5	30	12	based	base	VBN
cord-343791-0vykwml5	30	13	vaccines	vaccine	NNS
cord-343791-0vykwml5	30	14	circumvent	circumvent	VBP
cord-343791-0vykwml5	30	15	some	some	DT
cord-343791-0vykwml5	30	16	risks	risk	NNS
cord-343791-0vykwml5	30	17	associated	associate	VBN
cord-343791-0vykwml5	30	18	Supramolecular	Supramolecular	NNP
cord-343791-0vykwml5	30	19	materials	material	NNS
cord-343791-0vykwml5	30	20	composed	compose	VBN
cord-343791-0vykwml5	30	21	of	of	IN
cord-343791-0vykwml5	30	22	proteins	protein	NNS
cord-343791-0vykwml5	30	23	and	and	CC
cord-343791-0vykwml5	30	24	peptides	peptide	NNS
cord-343791-0vykwml5	30	25	have	have	VBP
cord-343791-0vykwml5	30	26	been	be	VBN
cord-343791-0vykwml5	30	27	receiving	receive	VBG
cord-343791-0vykwml5	30	28	considerable	considerable	JJ
cord-343791-0vykwml5	30	29	attention	attention	NN
cord-343791-0vykwml5	30	30	toward	toward	IN
cord-343791-0vykwml5	30	31	a	a	DT
cord-343791-0vykwml5	30	32	range	range	NN
cord-343791-0vykwml5	30	33	of	of	IN
cord-343791-0vykwml5	30	34	diseases	disease	NNS
cord-343791-0vykwml5	30	35	and	and	CC
cord-343791-0vykwml5	30	36	conditions	condition	NNS
cord-343791-0vykwml5	30	37	from	from	IN
cord-343791-0vykwml5	30	38	vaccines	vaccine	NNS
cord-343791-0vykwml5	30	39	to	to	IN
cord-343791-0vykwml5	30	40	drug	drug	NN
cord-343791-0vykwml5	30	41	delivery	delivery	NN
cord-343791-0vykwml5	30	42	.	.	.
cord-343791-0vykwml5	31	1	Owing	owe	VBG
cord-343791-0vykwml5	31	2	to	to	IN
cord-343791-0vykwml5	31	3	the	the	DT
cord-343791-0vykwml5	31	4	relative	relative	JJ
cord-343791-0vykwml5	31	5	newness	newness	NN
cord-343791-0vykwml5	31	6	of	of	IN
cord-343791-0vykwml5	31	7	this	this	DT
cord-343791-0vykwml5	31	8	class	class	NN
cord-343791-0vykwml5	31	9	of	of	IN
cord-343791-0vykwml5	31	10	materials	material	NNS
cord-343791-0vykwml5	31	11	,	,	,
cord-343791-0vykwml5	31	12	the	the	DT
cord-343791-0vykwml5	31	13	bulk	bulk	NN
cord-343791-0vykwml5	31	14	of	of	IN
cord-343791-0vykwml5	31	15	work	work	NN
cord-343791-0vykwml5	31	16	to	to	IN
cord-343791-0vykwml5	31	17	date	date	NN
cord-343791-0vykwml5	31	18	has	have	VBZ
cord-343791-0vykwml5	31	19	been	be	VBN
cord-343791-0vykwml5	31	20	preclinical	preclinical	JJ
cord-343791-0vykwml5	31	21	.	.	.
cord-343791-0vykwml5	32	1	However	however	RB
cord-343791-0vykwml5	32	2	,	,	,
cord-343791-0vykwml5	32	3	examples	example	NNS
cord-343791-0vykwml5	32	4	of	of	IN
cord-343791-0vykwml5	32	5	approved	approve	VBN
cord-343791-0vykwml5	32	6	treatments	treatment	NNS
cord-343791-0vykwml5	32	7	particularly	particularly	RB
cord-343791-0vykwml5	32	8	in	in	IN
cord-343791-0vykwml5	32	9	vaccines	vaccine	NNS
cord-343791-0vykwml5	32	10	,	,	,
cord-343791-0vykwml5	32	11	dentistry	dentistry	NN
cord-343791-0vykwml5	32	12	,	,	,
cord-343791-0vykwml5	32	13	and	and	CC
cord-343791-0vykwml5	32	14	hemostasis	hemostasis	NN
cord-343791-0vykwml5	32	15	demonstrate	demonstrate	VBP
cord-343791-0vykwml5	32	16	the	the	DT
cord-343791-0vykwml5	32	17	translational	translational	JJ
cord-343791-0vykwml5	32	18	potential	potential	NN
cord-343791-0vykwml5	32	19	of	of	IN
cord-343791-0vykwml5	32	20	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	32	21	polypeptides	polypeptide	NNS
cord-343791-0vykwml5	32	22	.	.	.
cord-343791-0vykwml5	33	1	Critical	critical	JJ
cord-343791-0vykwml5	33	2	milestones	milestone	NNS
cord-343791-0vykwml5	33	3	in	in	IN
cord-343791-0vykwml5	33	4	the	the	DT
cord-343791-0vykwml5	33	5	clinical	clinical	JJ
cord-343791-0vykwml5	33	6	development	development	NN
cord-343791-0vykwml5	33	7	of	of	IN
cord-343791-0vykwml5	33	8	this	this	DT
cord-343791-0vykwml5	33	9	class	class	NN
cord-343791-0vykwml5	33	10	of	of	IN
cord-343791-0vykwml5	33	11	materials	material	NNS
cord-343791-0vykwml5	33	12	and	and	CC
cord-343791-0vykwml5	34	1	currently	currently	RB
cord-343791-0vykwml5	34	2	approved	approve	VBN
cord-343791-0vykwml5	34	3	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	34	4	polypeptide	polypeptide	NN
cord-343791-0vykwml5	34	5	therapies	therapy	NNS
cord-343791-0vykwml5	34	6	are	be	VBP
cord-343791-0vykwml5	34	7	described	describe	VBN
cord-343791-0vykwml5	34	8	in	in	IN
cord-343791-0vykwml5	34	9	this	this	DT
cord-343791-0vykwml5	34	10	study	study	NN
cord-343791-0vykwml5	34	11	.	.	.
cord-343791-0vykwml5	35	1	Additional	additional	JJ
cord-343791-0vykwml5	35	2	examples	example	NNS
cord-343791-0vykwml5	35	3	of	of	IN
cord-343791-0vykwml5	35	4	not	not	RB
cord-343791-0vykwml5	35	5	-	-	HYPH
cord-343791-0vykwml5	35	6	yet	yet	RB
cord-343791-0vykwml5	35	7	-	-	HYPH
cord-343791-0vykwml5	35	8	approved	approve	VBN
cord-343791-0vykwml5	35	9	materials	material	NNS
cord-343791-0vykwml5	35	10	that	that	WDT
cord-343791-0vykwml5	35	11	are	be	VBP
cord-343791-0vykwml5	35	12	steadily	steadily	RB
cord-343791-0vykwml5	35	13	advancing	advance	VBG
cord-343791-0vykwml5	35	14	toward	toward	IN
cord-343791-0vykwml5	35	15	clinical	clinical	JJ
cord-343791-0vykwml5	35	16	use	use	NN
cord-343791-0vykwml5	35	17	are	be	VBP
cord-343791-0vykwml5	35	18	also	also	RB
cord-343791-0vykwml5	35	19	featured	feature	VBN
cord-343791-0vykwml5	35	20	.	.	.
cord-343791-0vykwml5	36	1	Spherical	spherical	JJ
cord-343791-0vykwml5	36	2	assemblies	assembly	NNS
cord-343791-0vykwml5	36	3	such	such	JJ
cord-343791-0vykwml5	36	4	as	as	IN
cord-343791-0vykwml5	36	5	virus	virus	NN
cord-343791-0vykwml5	36	6	-	-	HYPH
cord-343791-0vykwml5	36	7	like	like	JJ
cord-343791-0vykwml5	36	8	particles	particle	NNS
cord-343791-0vykwml5	36	9	,	,	,
cord-343791-0vykwml5	36	10	designed	design	VBN
cord-343791-0vykwml5	36	11	protein	protein	NN
cord-343791-0vykwml5	36	12	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	36	13	,	,	,
cord-343791-0vykwml5	36	14	and	and	CC
cord-343791-0vykwml5	36	15	spherical	spherical	JJ
cord-343791-0vykwml5	36	16	peptide	peptide	NN
cord-343791-0vykwml5	36	17	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	36	18	are	be	VBP
cord-343791-0vykwml5	36	19	highlighted	highlight	VBN
cord-343791-0vykwml5	36	20	,	,	,
cord-343791-0vykwml5	36	21	followed	follow	VBN
cord-343791-0vykwml5	36	22	by	by	IN
cord-343791-0vykwml5	36	23	fiber	fiber	NN
cord-343791-0vykwml5	36	24	-	-	HYPH
cord-343791-0vykwml5	36	25	forming	form	VBG
cord-343791-0vykwml5	36	26	systems	system	NNS
cord-343791-0vykwml5	36	27	such	such	JJ
cord-343791-0vykwml5	36	28	as	as	IN
cord-343791-0vykwml5	36	29	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	36	30	peptides	peptide	NNS
cord-343791-0vykwml5	36	31	,	,	,
cord-343791-0vykwml5	36	32	fiber	fiber	NN
cord-343791-0vykwml5	36	33	-	-	HYPH
cord-343791-0vykwml5	36	34	forming	form	VBG
cord-343791-0vykwml5	36	35	peptide	peptide	NN
cord-343791-0vykwml5	36	36	-	-	HYPH
cord-343791-0vykwml5	36	37	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	36	38	,	,	,
cord-343791-0vykwml5	36	39	and	and	CC
cord-343791-0vykwml5	36	40	filamentous	filamentous	JJ
cord-343791-0vykwml5	36	41	bacteriophages	bacteriophage	NNS
cord-343791-0vykwml5	36	42	.	.	.
cord-343791-0vykwml5	37	1	Over	over	IN
cord-343791-0vykwml5	37	2	the	the	DT
cord-343791-0vykwml5	37	3	past	past	JJ
cord-343791-0vykwml5	37	4	few	few	JJ
cord-343791-0vykwml5	37	5	decades	decade	NNS
cord-343791-0vykwml5	37	6	,	,	,
cord-343791-0vykwml5	37	7	researchers	researcher	NNS
cord-343791-0vykwml5	37	8	have	have	VBP
cord-343791-0vykwml5	37	9	built	build	VBN
cord-343791-0vykwml5	37	10	an	an	DT
cord-343791-0vykwml5	37	11	expansive	expansive	JJ
cord-343791-0vykwml5	37	12	toolbox	toolbox	NN
cord-343791-0vykwml5	37	13	of	of	IN
cord-343791-0vykwml5	37	14	self	self	NN
cord-343791-0vykwml5	37	15	-	-	HYPH
cord-343791-0vykwml5	37	16	assembling	assemble	VBG
cord-343791-0vykwml5	37	17	peptides	peptide	NNS
cord-343791-0vykwml5	37	18	and	and	CC
cord-343791-0vykwml5	37	19	proteins	protein	NNS
cord-343791-0vykwml5	37	20	that	that	WDT
cord-343791-0vykwml5	37	21	offer	offer	VBP
cord-343791-0vykwml5	37	22	unique	unique	JJ
cord-343791-0vykwml5	37	23	advantages	advantage	NNS
cord-343791-0vykwml5	37	24	over	over	IN
cord-343791-0vykwml5	37	25	traditional	traditional	JJ
cord-343791-0vykwml5	37	26	small	small	JJ
cord-343791-0vykwml5	37	27	molecules	molecule	NNS
cord-343791-0vykwml5	37	28	and	and	CC
cord-343791-0vykwml5	37	29	polymers	polymer	NNS
cord-343791-0vykwml5	37	30	for	for	IN
cord-343791-0vykwml5	37	31	a	a	DT
cord-343791-0vykwml5	37	32	range	range	NN
cord-343791-0vykwml5	37	33	of	of	IN
cord-343791-0vykwml5	37	34	biomedical	biomedical	JJ
cord-343791-0vykwml5	37	35	applications	application	NNS
cord-343791-0vykwml5	37	36	.	.	.
cord-343791-0vykwml5	38	1	The	the	DT
cord-343791-0vykwml5	38	2	first	first	JJ
cord-343791-0vykwml5	38	3	examples	example	NNS
cord-343791-0vykwml5	38	4	of	of	IN
cord-343791-0vykwml5	38	5	synthetic	synthetic	JJ
cord-343791-0vykwml5	38	6	self	self	NN
cord-343791-0vykwml5	38	7	-	-	HYPH
cord-343791-0vykwml5	38	8	assemblies	assembly	NNS
cord-343791-0vykwml5	38	9	were	be	VBD
cord-343791-0vykwml5	38	10	bioinspired	bioinspire	VBN
cord-343791-0vykwml5	38	11	derivatives	derivative	NNS
cord-343791-0vykwml5	38	12	of	of	IN
cord-343791-0vykwml5	38	13	native	native	JJ
cord-343791-0vykwml5	38	14	proteins	protein	NNS
cord-343791-0vykwml5	38	15	,	,	,
cord-343791-0vykwml5	38	16	but	but	CC
cord-343791-0vykwml5	38	17	an	an	DT
cord-343791-0vykwml5	38	18	increasing	increase	VBG
cord-343791-0vykwml5	38	19	familiarity	familiarity	NN
cord-343791-0vykwml5	38	20	with	with	IN
cord-343791-0vykwml5	38	21	the	the	DT
cord-343791-0vykwml5	38	22	design	design	NN
cord-343791-0vykwml5	38	23	rules	rule	NNS
cord-343791-0vykwml5	38	24	governing	govern	VBG
cord-343791-0vykwml5	38	25	supramolecular	supramolecular	NNP
cord-343791-0vykwml5	38	26	assembly	assembly	NNP
cord-343791-0vykwml5	38	27	has	have	VBZ
cord-343791-0vykwml5	38	28	more	more	RBR
cord-343791-0vykwml5	38	29	recently	recently	RB
cord-343791-0vykwml5	38	30	facilitated	facilitate	VBN
cord-343791-0vykwml5	38	31	the	the	DT
cord-343791-0vykwml5	38	32	de	de	FW
cord-343791-0vykwml5	38	33	novo	novo	NNP
cord-343791-0vykwml5	38	34	design	design	NN
cord-343791-0vykwml5	38	35	of	of	IN
cord-343791-0vykwml5	38	36	this	this	DT
cord-343791-0vykwml5	38	37	class	class	NN
cord-343791-0vykwml5	38	38	of	of	IN
cord-343791-0vykwml5	38	39	materials	material	NNS
cord-343791-0vykwml5	38	40	.	.	.
cord-343791-0vykwml5	39	1	The	the	DT
cord-343791-0vykwml5	39	2	ability	ability	NN
cord-343791-0vykwml5	39	3	to	to	TO
cord-343791-0vykwml5	39	4	create	create	VB
cord-343791-0vykwml5	39	5	predictable	predictable	JJ
cord-343791-0vykwml5	39	6	and	and	CC
cord-343791-0vykwml5	39	7	engineerable	engineerable	JJ
cord-343791-0vykwml5	39	8	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	39	9	structures	structure	NNS
cord-343791-0vykwml5	39	10	has	have	VBZ
cord-343791-0vykwml5	39	11	led	lead	VBN
cord-343791-0vykwml5	39	12	to	to	IN
cord-343791-0vykwml5	39	13	the	the	DT
cord-343791-0vykwml5	39	14	implementation	implementation	NN
cord-343791-0vykwml5	39	15	of	of	IN
cord-343791-0vykwml5	39	16	several	several	JJ
cord-343791-0vykwml5	39	17	of	of	IN
cord-343791-0vykwml5	39	18	these	these	DT
cord-343791-0vykwml5	39	19	materials	material	NNS
cord-343791-0vykwml5	39	20	within	within	IN
cord-343791-0vykwml5	39	21	biomedical	biomedical	JJ
cord-343791-0vykwml5	39	22	applications	application	NNS
cord-343791-0vykwml5	39	23	.	.	.
cord-343791-0vykwml5	40	1	In	in	IN
cord-343791-0vykwml5	40	2	this	this	DT
cord-343791-0vykwml5	40	3	review	review	NN
cord-343791-0vykwml5	40	4	,	,	,
cord-343791-0vykwml5	40	5	we	-PRON-	PRP
cord-343791-0vykwml5	40	6	highlight	highlight	VBP
cord-343791-0vykwml5	40	7	self	self	NN
cord-343791-0vykwml5	40	8	-	-	HYPH
cord-343791-0vykwml5	40	9	assembling	assemble	VBG
cord-343791-0vykwml5	40	10	polypeptide	polypeptide	NN
cord-343791-0vykwml5	40	11	materials	material	NNS
cord-343791-0vykwml5	40	12	that	that	WDT
cord-343791-0vykwml5	40	13	have	have	VBP
cord-343791-0vykwml5	40	14	been	be	VBN
cord-343791-0vykwml5	40	15	clinically	clinically	RB
cord-343791-0vykwml5	40	16	translated	translate	VBN
cord-343791-0vykwml5	40	17	.	.	.
cord-343791-0vykwml5	41	1	We	-PRON-	PRP
cord-343791-0vykwml5	41	2	will	will	MD
cord-343791-0vykwml5	41	3	also	also	RB
cord-343791-0vykwml5	41	4	discuss	discuss	VB
cord-343791-0vykwml5	41	5	the	the	DT
cord-343791-0vykwml5	41	6	advantageous	advantageous	JJ
cord-343791-0vykwml5	41	7	properties	property	NNS
cord-343791-0vykwml5	41	8	and	and	CC
cord-343791-0vykwml5	41	9	features	feature	NNS
cord-343791-0vykwml5	41	10	that	that	WDT
cord-343791-0vykwml5	41	11	have	have	VBP
cord-343791-0vykwml5	41	12	enabled	enable	VBN
cord-343791-0vykwml5	41	13	their	-PRON-	PRP$
cord-343791-0vykwml5	41	14	clinical	clinical	JJ
cord-343791-0vykwml5	41	15	implementation	implementation	NN
cord-343791-0vykwml5	41	16	.	.	.
cord-343791-0vykwml5	42	1	For	for	IN
cord-343791-0vykwml5	42	2	recent	recent	JJ
cord-343791-0vykwml5	42	3	reviews	review	NNS
cord-343791-0vykwml5	42	4	on	on	IN
cord-343791-0vykwml5	42	5	preclinical	preclinical	JJ
cord-343791-0vykwml5	42	6	work	work	NN
cord-343791-0vykwml5	42	7	relating	relate	VBG
cord-343791-0vykwml5	42	8	to	to	IN
cord-343791-0vykwml5	42	9	this	this	DT
cord-343791-0vykwml5	42	10	class	class	NN
cord-343791-0vykwml5	42	11	of	of	IN
cord-343791-0vykwml5	42	12	materials	material	NNS
cord-343791-0vykwml5	42	13	including	include	VBG
cord-343791-0vykwml5	42	14	self	self	NN
cord-343791-0vykwml5	42	15	-	-	HYPH
cord-343791-0vykwml5	42	16	assembling	assemble	VBG
cord-343791-0vykwml5	42	17	immunomodulating	immunomodulating	JJ
cord-343791-0vykwml5	42	18	materials	material	NNS
cord-343791-0vykwml5	42	19	,	,	,
cord-343791-0vykwml5	42	20	[	[	-LRB-
cord-343791-0vykwml5	42	21	1	1	CD
cord-343791-0vykwml5	42	22	,	,	,
cord-343791-0vykwml5	42	23	2	2	CD
cord-343791-0vykwml5	42	24	]	]	-RRB-
cord-343791-0vykwml5	42	25	self	self	NN
cord-343791-0vykwml5	42	26	-	-	HYPH
cord-343791-0vykwml5	42	27	assembled	assemble	VBN
cord-343791-0vykwml5	42	28	materials	material	NNS
cord-343791-0vykwml5	42	29	for	for	IN
cord-343791-0vykwml5	42	30	cell	cell	NN
cord-343791-0vykwml5	42	31	delivery	delivery	NN
cord-343791-0vykwml5	42	32	,	,	,
cord-343791-0vykwml5	42	33	[	[	-LRB-
cord-343791-0vykwml5	42	34	3	3	CD
cord-343791-0vykwml5	42	35	,	,	,
cord-343791-0vykwml5	42	36	4	4	CD
cord-343791-0vykwml5	42	37	]	]	-RRB-
cord-343791-0vykwml5	42	38	and	and	CC
cord-343791-0vykwml5	42	39	self	self	NN
cord-343791-0vykwml5	42	40	-	-	HYPH
cord-343791-0vykwml5	42	41	assembled	assemble	VBN
cord-343791-0vykwml5	42	42	biomaterials	biomaterial	NNS
cord-343791-0vykwml5	42	43	as	as	IN
cord-343791-0vykwml5	42	44	a	a	DT
cord-343791-0vykwml5	42	45	whole	whole	NN
cord-343791-0vykwml5	42	46	,	,	,
cord-343791-0vykwml5	42	47	[	[	-LRB-
cord-343791-0vykwml5	42	48	5	5	CD
cord-343791-0vykwml5	42	49	,	,	,
cord-343791-0vykwml5	42	50	6	6	CD
cord-343791-0vykwml5	42	51	]	]	-RRB-
cord-343791-0vykwml5	42	52	the	the	DT
cord-343791-0vykwml5	42	53	reader	reader	NN
cord-343791-0vykwml5	42	54	is	be	VBZ
cord-343791-0vykwml5	42	55	referred	refer	VBN
cord-343791-0vykwml5	42	56	to	to	IN
cord-343791-0vykwml5	42	57	the	the	DT
cord-343791-0vykwml5	42	58	review	review	NN
cord-343791-0vykwml5	42	59	articles	article	NNS
cord-343791-0vykwml5	42	60	indicated	indicate	VBD
cord-343791-0vykwml5	42	61	.	.	.
cord-343791-0vykwml5	43	1	Properly	properly	RB
cord-343791-0vykwml5	43	2	designed	design	VBN
cord-343791-0vykwml5	43	3	polypeptides	polypeptide	NNS
cord-343791-0vykwml5	43	4	can	can	MD
cord-343791-0vykwml5	43	5	self	self	NN
cord-343791-0vykwml5	43	6	-	-	HYPH
cord-343791-0vykwml5	43	7	assemble	assemble	VB
cord-343791-0vykwml5	43	8	into	into	IN
cord-343791-0vykwml5	43	9	a	a	DT
cord-343791-0vykwml5	43	10	range	range	NN
cord-343791-0vykwml5	43	11	of	of	IN
cord-343791-0vykwml5	43	12	predictable	predictable	JJ
cord-343791-0vykwml5	43	13	structures	structure	NNS
cord-343791-0vykwml5	43	14	including	include	VBG
cord-343791-0vykwml5	43	15	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	43	16	,	,	,
cord-343791-0vykwml5	43	17	micelles	micelle	NNS
cord-343791-0vykwml5	43	18	,	,	,
cord-343791-0vykwml5	43	19	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	43	20	,	,	,
cord-343791-0vykwml5	43	21	and	and	CC
cord-343791-0vykwml5	43	22	extended	extended	JJ
cord-343791-0vykwml5	43	23	networks	network	NNS
cord-343791-0vykwml5	43	24	.	.	.
cord-343791-0vykwml5	44	1	These	these	DT
cord-343791-0vykwml5	44	2	architectures	architecture	NNS
cord-343791-0vykwml5	44	3	are	be	VBP
cord-343791-0vykwml5	44	4	attenuated	attenuate	VBN
cord-343791-0vykwml5	44	5	or	or	CC
cord-343791-0vykwml5	44	6	inactivated	inactivate	VBN
cord-343791-0vykwml5	44	7	live	live	JJ
cord-343791-0vykwml5	44	8	viruses	virus	NNS
cord-343791-0vykwml5	44	9	,	,	,
cord-343791-0vykwml5	44	10	highlighting	highlight	VBG
cord-343791-0vykwml5	44	11	an	an	DT
cord-343791-0vykwml5	44	12	advantage	advantage	NN
cord-343791-0vykwml5	44	13	of	of	IN
cord-343791-0vykwml5	44	14	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	44	15	systems	system	NNS
cord-343791-0vykwml5	44	16	:	:	:
cord-343791-0vykwml5	44	17	they	-PRON-	PRP
cord-343791-0vykwml5	44	18	are	be	VBP
cord-343791-0vykwml5	44	19	more	more	RBR
cord-343791-0vykwml5	44	20	compositionally	compositionally	RB
cord-343791-0vykwml5	44	21	defined	define	VBN
cord-343791-0vykwml5	44	22	than	than	IN
cord-343791-0vykwml5	44	23	the	the	DT
cord-343791-0vykwml5	44	24	analogous	analogous	JJ
cord-343791-0vykwml5	44	25	biological	biological	JJ
cord-343791-0vykwml5	44	26	structures	structure	NNS
cord-343791-0vykwml5	44	27	,	,	,
cord-343791-0vykwml5	44	28	viruses	virus	NNS
cord-343791-0vykwml5	44	29	.	.	.
cord-343791-0vykwml5	45	1	They	-PRON-	PRP
cord-343791-0vykwml5	45	2	also	also	RB
cord-343791-0vykwml5	45	3	have	have	VBP
cord-343791-0vykwml5	45	4	advantages	advantage	NNS
cord-343791-0vykwml5	45	5	over	over	IN
cord-343791-0vykwml5	45	6	subunit	subunit	NN
cord-343791-0vykwml5	45	7	vaccines	vaccine	NNS
cord-343791-0vykwml5	45	8	based	base	VBN
cord-343791-0vykwml5	45	9	on	on	IN
cord-343791-0vykwml5	45	10	viral	viral	JJ
cord-343791-0vykwml5	45	11	proteins	protein	NNS
cord-343791-0vykwml5	45	12	or	or	CC
cord-343791-0vykwml5	45	13	peptides	peptide	NNS
cord-343791-0vykwml5	45	14	conjugated	conjugate	VBN
cord-343791-0vykwml5	45	15	to	to	IN
cord-343791-0vykwml5	45	16	carrier	carrier	NN
cord-343791-0vykwml5	45	17	proteins	protein	NNS
cord-343791-0vykwml5	45	18	,	,	,
cord-343791-0vykwml5	45	19	which	which	WDT
cord-343791-0vykwml5	45	20	commonly	commonly	RB
cord-343791-0vykwml5	45	21	require	require	VBP
cord-343791-0vykwml5	45	22	higher	high	JJR
cord-343791-0vykwml5	45	23	and	and	CC
cord-343791-0vykwml5	45	24	more	more	RBR
cord-343791-0vykwml5	45	25	frequent	frequent	JJ
cord-343791-0vykwml5	45	26	dosing	dosing	NN
cord-343791-0vykwml5	45	27	and	and	CC
cord-343791-0vykwml5	45	28	adjuvants	adjuvant	NNS
cord-343791-0vykwml5	45	29	to	to	TO
cord-343791-0vykwml5	45	30	be	be	VB
cord-343791-0vykwml5	45	31	as	as	RB
cord-343791-0vykwml5	45	32	effective	effective	JJ
cord-343791-0vykwml5	45	33	as	as	IN
cord-343791-0vykwml5	45	34	inactivated	inactivate	VBN
cord-343791-0vykwml5	45	35	or	or	CC
cord-343791-0vykwml5	45	36	attenuated	attenuated	JJ
cord-343791-0vykwml5	45	37	viruses	virus	NNS
cord-343791-0vykwml5	45	38	.	.	.
cord-343791-0vykwml5	46	1	[	[	-LRB-
cord-343791-0vykwml5	46	2	19	19	CD
cord-343791-0vykwml5	46	3	]	]	-RRB-
cord-343791-0vykwml5	47	1	As	as	IN
cord-343791-0vykwml5	47	2	alternatives	alternative	NNS
cord-343791-0vykwml5	47	3	to	to	IN
cord-343791-0vykwml5	47	4	these	these	DT
cord-343791-0vykwml5	47	5	previous	previous	JJ
cord-343791-0vykwml5	47	6	platforms	platform	NNS
cord-343791-0vykwml5	47	7	,	,	,
cord-343791-0vykwml5	47	8	VLPs	vlp	NNS
cord-343791-0vykwml5	47	9	were	be	VBD
cord-343791-0vykwml5	47	10	developed	develop	VBN
cord-343791-0vykwml5	47	11	to	to	TO
cord-343791-0vykwml5	47	12	display	display	VB
cord-343791-0vykwml5	47	13	an	an	DT
cord-343791-0vykwml5	47	14	array	array	NN
cord-343791-0vykwml5	47	15	of	of	IN
cord-343791-0vykwml5	47	16	epitopes	epitope	NNS
cord-343791-0vykwml5	47	17	that	that	WDT
cord-343791-0vykwml5	47	18	mimic	mimic	VBP
cord-343791-0vykwml5	47	19	the	the	DT
cord-343791-0vykwml5	47	20	surface	surface	NN
cord-343791-0vykwml5	47	21	of	of	IN
cord-343791-0vykwml5	47	22	native	native	JJ
cord-343791-0vykwml5	47	23	viruses	virus	NNS
cord-343791-0vykwml5	47	24	more	more	RBR
cord-343791-0vykwml5	47	25	effectively	effectively	RB
cord-343791-0vykwml5	47	26	than	than	IN
cord-343791-0vykwml5	47	27	subunit	subunit	NN
cord-343791-0vykwml5	47	28	or	or	CC
cord-343791-0vykwml5	47	29	peptide	peptide	JJ
cord-343791-0vykwml5	47	30	vaccines	vaccine	NNS
cord-343791-0vykwml5	47	31	,	,	,
cord-343791-0vykwml5	47	32	thus	thus	RB
cord-343791-0vykwml5	47	33	improving	improve	VBG
cord-343791-0vykwml5	47	34	their	-PRON-	PRP$
cord-343791-0vykwml5	47	35	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	47	36	properties	property	NNS
cord-343791-0vykwml5	47	37	.	.	.
cord-343791-0vykwml5	48	1	[	[	-LRB-
cord-343791-0vykwml5	48	2	20	20	CD
cord-343791-0vykwml5	48	3	]	]	-RRB-
cord-343791-0vykwml5	48	4	VLPs	vlp	NNS
cord-343791-0vykwml5	48	5	,	,	,
cord-343791-0vykwml5	48	6	like	like	IN
cord-343791-0vykwml5	48	7	viruses	virus	NNS
cord-343791-0vykwml5	48	8	,	,	,
cord-343791-0vykwml5	48	9	come	come	VB
cord-343791-0vykwml5	48	10	in	in	IN
cord-343791-0vykwml5	48	11	a	a	DT
cord-343791-0vykwml5	48	12	range	range	NN
cord-343791-0vykwml5	48	13	structures	structure	NNS
cord-343791-0vykwml5	48	14	including	include	VBG
cord-343791-0vykwml5	48	15	those	those	DT
cord-343791-0vykwml5	48	16	with	with	IN
cord-343791-0vykwml5	48	17	a	a	DT
cord-343791-0vykwml5	48	18	single	single	JJ
cord-343791-0vykwml5	48	19	capsid	capsid	NN
cord-343791-0vykwml5	48	20	protein	protein	NN
cord-343791-0vykwml5	48	21	,	,	,
cord-343791-0vykwml5	48	22	multiple	multiple	JJ
cord-343791-0vykwml5	48	23	capsid	capsid	NN
cord-343791-0vykwml5	48	24	proteins	protein	NNS
cord-343791-0vykwml5	48	25	,	,	,
cord-343791-0vykwml5	48	26	or	or	CC
cord-343791-0vykwml5	48	27	those	those	DT
cord-343791-0vykwml5	48	28	without	without	IN
cord-343791-0vykwml5	48	29	lipid	lipid	NN
cord-343791-0vykwml5	48	30	envelopes	envelope	NNS
cord-343791-0vykwml5	48	31	.	.	.
cord-343791-0vykwml5	49	1	[	[	-LRB-
cord-343791-0vykwml5	49	2	21	21	CD
cord-343791-0vykwml5	49	3	]	]	-RRB-
cord-343791-0vykwml5	49	4	VLPs	vlp	NNS
cord-343791-0vykwml5	49	5	consisting	consist	VBG
cord-343791-0vykwml5	49	6	of	of	IN
cord-343791-0vykwml5	49	7	multiple	multiple	JJ
cord-343791-0vykwml5	49	8	capsid	capsid	NN
cord-343791-0vykwml5	49	9	proteins	protein	NNS
cord-343791-0vykwml5	49	10	are	be	VBP
cord-343791-0vykwml5	49	11	expressed	express	VBN
cord-343791-0vykwml5	49	12	and	and	CC
cord-343791-0vykwml5	49	13	assembled	assemble	VBN
cord-343791-0vykwml5	49	14	via	via	IN
cord-343791-0vykwml5	49	15	subsequent	subsequent	JJ
cord-343791-0vykwml5	49	16	processing	processing	NN
cord-343791-0vykwml5	49	17	or	or	CC
cord-343791-0vykwml5	49	18	by	by	IN
cord-343791-0vykwml5	49	19	co	co	NN
cord-343791-0vykwml5	49	20	-	-	NN
cord-343791-0vykwml5	49	21	expression	expression	NN
cord-343791-0vykwml5	49	22	of	of	IN
cord-343791-0vykwml5	49	23	polycistronic	polycistronic	JJ
cord-343791-0vykwml5	49	24	genes	gene	NNS
cord-343791-0vykwml5	49	25	within	within	IN
cord-343791-0vykwml5	49	26	a	a	DT
cord-343791-0vykwml5	49	27	cell	cell	NN
cord-343791-0vykwml5	49	28	.	.	.
cord-343791-0vykwml5	50	1	Several	several	JJ
cord-343791-0vykwml5	50	2	additional	additional	JJ
cord-343791-0vykwml5	50	3	aspects	aspect	NNS
cord-343791-0vykwml5	50	4	of	of	IN
cord-343791-0vykwml5	50	5	VLPs	vlp	NNS
cord-343791-0vykwml5	50	6	have	have	VBP
cord-343791-0vykwml5	50	7	contributed	contribute	VBN
cord-343791-0vykwml5	50	8	to	to	IN
cord-343791-0vykwml5	50	9	their	-PRON-	PRP$
cord-343791-0vykwml5	50	10	clinical	clinical	JJ
cord-343791-0vykwml5	50	11	translation	translation	NN
cord-343791-0vykwml5	50	12	.	.	.
cord-343791-0vykwml5	51	1	Whereas	whereas	IN
cord-343791-0vykwml5	51	2	the	the	DT
cord-343791-0vykwml5	51	3	first	first	JJ
cord-343791-0vykwml5	51	4	translated	translate	VBN
cord-343791-0vykwml5	51	5	VLP	VLP	NNP
cord-343791-0vykwml5	51	6	-	-	HYPH
cord-343791-0vykwml5	51	7	based	base	VBN
cord-343791-0vykwml5	51	8	vaccines	vaccine	NNS
cord-343791-0vykwml5	51	9	raised	raise	VBD
cord-343791-0vykwml5	51	10	antibodies	antibody	NNS
cord-343791-0vykwml5	51	11	against	against	IN
cord-343791-0vykwml5	51	12	the	the	DT
cord-343791-0vykwml5	51	13	naturally	naturally	RB
cord-343791-0vykwml5	51	14	occurring	occur	VBG
cord-343791-0vykwml5	51	15	virus	virus	NN
cord-343791-0vykwml5	51	16	capsid	capsid	NN
cord-343791-0vykwml5	51	17	proteins	protein	NNS
cord-343791-0vykwml5	51	18	of	of	IN
cord-343791-0vykwml5	51	19	the	the	DT
cord-343791-0vykwml5	51	20	assembled	assemble	VBN
cord-343791-0vykwml5	51	21	structure	structure	NN
cord-343791-0vykwml5	51	22	,	,	,
cord-343791-0vykwml5	51	23	VLPs	vlp	NNS
cord-343791-0vykwml5	51	24	can	can	MD
cord-343791-0vykwml5	51	25	also	also	RB
cord-343791-0vykwml5	51	26	be	be	VB
cord-343791-0vykwml5	51	27	used	use	VBN
cord-343791-0vykwml5	51	28	as	as	IN
cord-343791-0vykwml5	51	29	vehicles	vehicle	NNS
cord-343791-0vykwml5	51	30	to	to	TO
cord-343791-0vykwml5	51	31	display	display	VB
cord-343791-0vykwml5	51	32	heterologous	heterologous	JJ
cord-343791-0vykwml5	51	33	antigens	antigen	NNS
cord-343791-0vykwml5	51	34	associated	associate	VBN
cord-343791-0vykwml5	51	35	with	with	IN
cord-343791-0vykwml5	51	36	other	other	JJ
cord-343791-0vykwml5	51	37	infectious	infectious	JJ
cord-343791-0vykwml5	51	38	diseases	disease	NNS
cord-343791-0vykwml5	51	39	.	.	.
cord-343791-0vykwml5	52	1	This	this	DT
cord-343791-0vykwml5	52	2	modularity	modularity	NN
cord-343791-0vykwml5	52	3	of	of	IN
cord-343791-0vykwml5	52	4	the	the	DT
cord-343791-0vykwml5	52	5	platform	platform	NN
cord-343791-0vykwml5	52	6	is	be	VBZ
cord-343791-0vykwml5	52	7	described	describe	VBN
cord-343791-0vykwml5	52	8	[	[	-LRB-
cord-343791-0vykwml5	52	9	7	7	CD
cord-343791-0vykwml5	52	10	]	]	-RRB-
cord-343791-0vykwml5	52	11	Copyright	Copyright	NNP
cord-343791-0vykwml5	52	12	2007	2007	CD
cord-343791-0vykwml5	52	13	,	,	,
cord-343791-0vykwml5	52	14	ASBMB	ASBMB	NNP
cord-343791-0vykwml5	52	15	.	.	.
cord-343791-0vykwml5	53	1	(	(	-LRB-
cord-343791-0vykwml5	53	2	A	a	DT
cord-343791-0vykwml5	53	3	,	,	,
cord-343791-0vykwml5	53	4	right	right	JJ
cord-343791-0vykwml5	53	5	)	)	-RRB-
cord-343791-0vykwml5	53	6	Adapted	adapt	VBN
cord-343791-0vykwml5	53	7	with	with	IN
cord-343791-0vykwml5	53	8	permission	permission	NN
cord-343791-0vykwml5	53	9	.	.	.
cord-343791-0vykwml5	54	1	[	[	-LRB-
cord-343791-0vykwml5	54	2	8	8	CD
cord-343791-0vykwml5	54	3	]	]	-RRB-
cord-343791-0vykwml5	54	4	Copyright	copyright	NN
cord-343791-0vykwml5	54	5	2017	2017	CD
cord-343791-0vykwml5	54	6	,	,	,
cord-343791-0vykwml5	54	7	Elsevier	Elsevier	NNP
cord-343791-0vykwml5	54	8	.	.	.
cord-343791-0vykwml5	55	1	(	(	-LRB-
cord-343791-0vykwml5	55	2	B	b	NN
cord-343791-0vykwml5	55	3	)	)	-RRB-
cord-343791-0vykwml5	55	4	Adapted	adapt	VBN
cord-343791-0vykwml5	55	5	with	with	IN
cord-343791-0vykwml5	55	6	permission	permission	NN
cord-343791-0vykwml5	55	7	.	.	.
cord-343791-0vykwml5	56	1	[	[	-LRB-
cord-343791-0vykwml5	56	2	9	9	CD
cord-343791-0vykwml5	56	3	]	]	-RRB-
cord-343791-0vykwml5	56	4	Copyright	copyright	NN
cord-343791-0vykwml5	56	5	2006	2006	CD
cord-343791-0vykwml5	56	6	,	,	,
cord-343791-0vykwml5	56	7	Elsevier	Elsevier	NNP
cord-343791-0vykwml5	56	8	.	.	.
cord-343791-0vykwml5	57	1	(	(	-LRB-
cord-343791-0vykwml5	57	2	C	C	NNP
cord-343791-0vykwml5	57	3	)	)	-RRB-
cord-343791-0vykwml5	57	4	Adapted	adapt	VBN
cord-343791-0vykwml5	57	5	with	with	IN
cord-343791-0vykwml5	57	6	permission	permission	NN
cord-343791-0vykwml5	57	7	.	.	.
cord-343791-0vykwml5	58	1	[	[	-LRB-
cord-343791-0vykwml5	58	2	10	10	CD
cord-343791-0vykwml5	58	3	]	]	-RRB-
cord-343791-0vykwml5	58	4	become	become	VBN
cord-343791-0vykwml5	58	5	increasingly	increasingly	RB
cord-343791-0vykwml5	58	6	complex	complex	JJ
cord-343791-0vykwml5	58	7	,	,	,
cord-343791-0vykwml5	58	8	they	-PRON-	PRP
cord-343791-0vykwml5	58	9	become	become	VBP
cord-343791-0vykwml5	58	10	increasingly	increasingly	RB
cord-343791-0vykwml5	58	11	more	more	RBR
cord-343791-0vykwml5	58	12	challenging	challenging	JJ
cord-343791-0vykwml5	58	13	to	to	TO
cord-343791-0vykwml5	58	14	manufacture	manufacture	VB
cord-343791-0vykwml5	58	15	at	at	IN
cord-343791-0vykwml5	58	16	a	a	DT
cord-343791-0vykwml5	58	17	large	large	JJ
cord-343791-0vykwml5	58	18	scale	scale	NN
cord-343791-0vykwml5	58	19	.	.	.
cord-343791-0vykwml5	59	1	Multi	multi	JJ
cord-343791-0vykwml5	59	2	-	-	JJ
cord-343791-0vykwml5	59	3	subunit	subunit	JJ
cord-343791-0vykwml5	59	4	,	,	,
cord-343791-0vykwml5	59	5	chimeric	chimeric	JJ
cord-343791-0vykwml5	59	6	,	,	,
cord-343791-0vykwml5	59	7	and	and	CC
cord-343791-0vykwml5	59	8	other	other	JJ
cord-343791-0vykwml5	59	9	types	type	NNS
cord-343791-0vykwml5	59	10	of	of	IN
cord-343791-0vykwml5	59	11	VLPs	vlp	NNS
cord-343791-0vykwml5	59	12	must	must	MD
cord-343791-0vykwml5	59	13	overcome	overcome	VB
cord-343791-0vykwml5	59	14	these	these	DT
cord-343791-0vykwml5	59	15	challenges	challenge	NNS
cord-343791-0vykwml5	59	16	.	.	.
cord-343791-0vykwml5	60	1	Fortunately	fortunately	RB
cord-343791-0vykwml5	60	2	,	,	,
cord-343791-0vykwml5	60	3	a	a	DT
cord-343791-0vykwml5	60	4	large	large	JJ
cord-343791-0vykwml5	60	5	assortment	assortment	NN
cord-343791-0vykwml5	60	6	of	of	IN
cord-343791-0vykwml5	60	7	expression	expression	NN
cord-343791-0vykwml5	60	8	systems	system	NNS
cord-343791-0vykwml5	60	9	(	(	-LRB-
cord-343791-0vykwml5	60	10	bacterial	bacterial	JJ
cord-343791-0vykwml5	60	11	,	,	,
cord-343791-0vykwml5	60	12	yeast	yeast	NN
cord-343791-0vykwml5	60	13	,	,	,
cord-343791-0vykwml5	60	14	insect	insect	NN
cord-343791-0vykwml5	60	15	,	,	,
cord-343791-0vykwml5	60	16	plant	plant	NN
cord-343791-0vykwml5	60	17	,	,	,
cord-343791-0vykwml5	60	18	mammalian	mammalian	JJ
cord-343791-0vykwml5	60	19	,	,	,
cord-343791-0vykwml5	60	20	and	and	CC
cord-343791-0vykwml5	60	21	cell	cell	NN
cord-343791-0vykwml5	60	22	-	-	HYPH
cord-343791-0vykwml5	60	23	free	free	JJ
cord-343791-0vykwml5	60	24	)	)	-RRB-
cord-343791-0vykwml5	60	25	have	have	VBP
cord-343791-0vykwml5	60	26	been	be	VBN
cord-343791-0vykwml5	60	27	developed	develop	VBN
cord-343791-0vykwml5	60	28	for	for	IN
cord-343791-0vykwml5	60	29	the	the	DT
cord-343791-0vykwml5	60	30	production	production	NN
cord-343791-0vykwml5	60	31	of	of	IN
cord-343791-0vykwml5	60	32	new	new	JJ
cord-343791-0vykwml5	60	33	VLP	VLP	NNP
cord-343791-0vykwml5	60	34	platform	platform	NN
cord-343791-0vykwml5	60	35	candidates	candidate	NNS
cord-343791-0vykwml5	60	36	.	.	.
cord-343791-0vykwml5	61	1	The	the	DT
cord-343791-0vykwml5	61	2	idea	idea	NN
cord-343791-0vykwml5	61	3	of	of	IN
cord-343791-0vykwml5	61	4	using	use	VBG
cord-343791-0vykwml5	61	5	noninfectious	noninfectious	JJ
cord-343791-0vykwml5	61	6	virus	virus	NN
cord-343791-0vykwml5	61	7	particles	particle	NNS
cord-343791-0vykwml5	61	8	to	to	TO
cord-343791-0vykwml5	61	9	develop	develop	VB
cord-343791-0vykwml5	61	10	prophylactic	prophylactic	JJ
cord-343791-0vykwml5	61	11	human	human	JJ
cord-343791-0vykwml5	61	12	vaccines	vaccine	NNS
cord-343791-0vykwml5	61	13	first	first	RB
cord-343791-0vykwml5	61	14	became	become	VBD
cord-343791-0vykwml5	61	15	attractive	attractive	JJ
cord-343791-0vykwml5	61	16	when	when	WRB
cord-343791-0vykwml5	61	17	noninfectious	noninfectious	JJ
cord-343791-0vykwml5	61	18	VLPs	vlp	NNS
cord-343791-0vykwml5	61	19	composed	compose	VBN
cord-343791-0vykwml5	61	20	of	of	IN
cord-343791-0vykwml5	61	21	the	the	DT
cord-343791-0vykwml5	61	22	surface	surface	NN
cord-343791-0vykwml5	61	23	antigen	antigen	NN
cord-343791-0vykwml5	61	24	from	from	IN
cord-343791-0vykwml5	61	25	the	the	DT
cord-343791-0vykwml5	61	26	hepatitis	hepatitis	NN
cord-343791-0vykwml5	61	27	B	B	NNP
cord-343791-0vykwml5	61	28	virus	virus	NN
cord-343791-0vykwml5	61	29	(	(	-LRB-
cord-343791-0vykwml5	61	30	HBsAg	hbsag	ADD
cord-343791-0vykwml5	61	31	,	,	,
cord-343791-0vykwml5	61	32	also	also	RB
cord-343791-0vykwml5	61	33	known	know	VBN
cord-343791-0vykwml5	61	34	as	as	IN
cord-343791-0vykwml5	61	35	the	the	DT
cord-343791-0vykwml5	61	36	Australia	Australia	NNP
cord-343791-0vykwml5	61	37	antigen	antigen	NN
cord-343791-0vykwml5	61	38	)	)	-RRB-
cord-343791-0vykwml5	61	39	,	,	,
cord-343791-0vykwml5	61	40	were	be	VBD
cord-343791-0vykwml5	61	41	discovered	discover	VBN
cord-343791-0vykwml5	61	42	in	in	IN
cord-343791-0vykwml5	61	43	human	human	JJ
cord-343791-0vykwml5	61	44	sera	sera	NNP
cord-343791-0vykwml5	61	45	in	in	IN
cord-343791-0vykwml5	61	46	1965	1965	CD
cord-343791-0vykwml5	61	47	.	.	.
cord-343791-0vykwml5	62	1	[	[	-LRB-
cord-343791-0vykwml5	62	2	20	20	CD
cord-343791-0vykwml5	62	3	]	]	-RRB-
cord-343791-0vykwml5	63	1	The	the	DT
cord-343791-0vykwml5	63	2	first	first	JJ
cord-343791-0vykwml5	63	3	VLPbased	vlpbased	JJ
cord-343791-0vykwml5	63	4	human	human	JJ
cord-343791-0vykwml5	63	5	vaccine	vaccine	NN
cord-343791-0vykwml5	63	6	consisted	consist	VBD
cord-343791-0vykwml5	63	7	of	of	IN
cord-343791-0vykwml5	63	8	HBsAg	HBsAg	NNP
cord-343791-0vykwml5	63	9	VLPs	vlp	NNS
cord-343791-0vykwml5	63	10	derived	derive	VBN
cord-343791-0vykwml5	63	11	from	from	IN
cord-343791-0vykwml5	63	12	human	human	JJ
cord-343791-0vykwml5	63	13	plasma	plasma	NN
cord-343791-0vykwml5	63	14	and	and	CC
cord-343791-0vykwml5	63	15	was	be	VBD
cord-343791-0vykwml5	63	16	licensed	license	VBN
cord-343791-0vykwml5	63	17	in	in	IN
cord-343791-0vykwml5	63	18	the	the	DT
cord-343791-0vykwml5	63	19	United	United	NNP
cord-343791-0vykwml5	63	20	States	States	NNP
cord-343791-0vykwml5	63	21	in	in	IN
cord-343791-0vykwml5	63	22	1981	1981	CD
cord-343791-0vykwml5	64	1	(	(	-LRB-
cord-343791-0vykwml5	64	2	Figure	figure	NN
cord-343791-0vykwml5	64	3	3	3	CD
cord-343791-0vykwml5	64	4	)	)	-RRB-
cord-343791-0vykwml5	64	5	.	.	.
cord-343791-0vykwml5	65	1	Subsequently	subsequently	RB
cord-343791-0vykwml5	65	2	,	,	,
cord-343791-0vykwml5	65	3	after	after	IN
cord-343791-0vykwml5	65	4	the	the	DT
cord-343791-0vykwml5	65	5	advent	advent	NN
cord-343791-0vykwml5	65	6	of	of	IN
cord-343791-0vykwml5	65	7	HIV	HIV	NNP
cord-343791-0vykwml5	65	8	/	/	SYM
cord-343791-0vykwml5	65	9	AIDS	AIDS	NNP
cord-343791-0vykwml5	65	10	rendered	render	VBN
cord-343791-0vykwml5	65	11	plasma	plasma	NN
cord-343791-0vykwml5	65	12	-	-	HYPH
cord-343791-0vykwml5	65	13	derived	derive	VBN
cord-343791-0vykwml5	65	14	products	product	NNS
cord-343791-0vykwml5	65	15	more	more	RBR
cord-343791-0vykwml5	65	16	challenging	challenging	JJ
cord-343791-0vykwml5	65	17	,	,	,
cord-343791-0vykwml5	65	18	the	the	DT
cord-343791-0vykwml5	65	19	HBsAg	hbsag	CD
cord-343791-0vykwml5	65	20	particles	particle	NNS
cord-343791-0vykwml5	65	21	were	be	VBD
cord-343791-0vykwml5	65	22	produced	produce	VBN
cord-343791-0vykwml5	65	23	recombinantly	recombinantly	RB
cord-343791-0vykwml5	65	24	in	in	IN
cord-343791-0vykwml5	65	25	yeast	yeast	NN
cord-343791-0vykwml5	65	26	,	,	,
cord-343791-0vykwml5	65	27	and	and	CC
cord-343791-0vykwml5	65	28	the	the	DT
cord-343791-0vykwml5	65	29	first	first	JJ
cord-343791-0vykwml5	65	30	recombinant	recombinant	JJ
cord-343791-0vykwml5	65	31	human	human	JJ
cord-343791-0vykwml5	65	32	vaccine	vaccine	NN
cord-343791-0vykwml5	65	33	,	,	,
cord-343791-0vykwml5	65	34	Recombivax	Recombivax	NNP
cord-343791-0vykwml5	65	35	HB	HB	NNP
cord-343791-0vykwml5	65	36	,	,	,
cord-343791-0vykwml5	65	37	was	be	VBD
cord-343791-0vykwml5	65	38	licensed	license	VBN
cord-343791-0vykwml5	65	39	by	by	IN
cord-343791-0vykwml5	65	40	Merck	Merck	NNP
cord-343791-0vykwml5	65	41	in	in	IN
cord-343791-0vykwml5	65	42	1986	1986	CD
cord-343791-0vykwml5	65	43	.	.	.
cord-343791-0vykwml5	66	1	[	[	-LRB-
cord-343791-0vykwml5	66	2	22	22	CD
cord-343791-0vykwml5	66	3	]	]	-RRB-
cord-343791-0vykwml5	67	1	Three	three	CD
cord-343791-0vykwml5	67	2	years	year	NNS
cord-343791-0vykwml5	67	3	later	later	RB
cord-343791-0vykwml5	67	4	in	in	IN
cord-343791-0vykwml5	67	5	1989	1989	CD
cord-343791-0vykwml5	67	6	,	,	,
cord-343791-0vykwml5	67	7	Engerix	Engerix	NNP
cord-343791-0vykwml5	67	8	-	-	HYPH
cord-343791-0vykwml5	67	9	B	B	NNP
cord-343791-0vykwml5	67	10	,	,	,
cord-343791-0vykwml5	67	11	a	a	DT
cord-343791-0vykwml5	67	12	similar	similar	JJ
cord-343791-0vykwml5	67	13	HBV	HBV	NNP
cord-343791-0vykwml5	67	14	vaccine	vaccine	NN
cord-343791-0vykwml5	67	15	,	,	,
cord-343791-0vykwml5	67	16	was	be	VBD
cord-343791-0vykwml5	67	17	licensed	license	VBN
cord-343791-0vykwml5	67	18	by	by	IN
cord-343791-0vykwml5	67	19	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-343791-0vykwml5	67	20	.	.	.
cord-343791-0vykwml5	68	1	It	-PRON-	PRP
cord-343791-0vykwml5	68	2	took	take	VBD
cord-343791-0vykwml5	68	3	another	another	DT
cord-343791-0vykwml5	68	4	17	17	CD
cord-343791-0vykwml5	68	5	years	year	NNS
cord-343791-0vykwml5	68	6	before	before	IN
cord-343791-0vykwml5	68	7	the	the	DT
cord-343791-0vykwml5	68	8	next	next	JJ
cord-343791-0vykwml5	68	9	recombinant	recombinant	JJ
cord-343791-0vykwml5	68	10	VLP	VLP	NNP
cord-343791-0vykwml5	68	11	-	-	HYPH
cord-343791-0vykwml5	68	12	based	base	VBN
cord-343791-0vykwml5	68	13	vaccine	vaccine	NN
cord-343791-0vykwml5	68	14	was	be	VBD
cord-343791-0vykwml5	68	15	licensed	license	VBN
cord-343791-0vykwml5	68	16	for	for	IN
cord-343791-0vykwml5	68	17	human	human	JJ
cord-343791-0vykwml5	68	18	use	use	NN
cord-343791-0vykwml5	68	19	.	.	.
cord-343791-0vykwml5	69	1	[	[	-LRB-
cord-343791-0vykwml5	69	2	13	13	CD
cord-343791-0vykwml5	69	3	]	]	-RRB-
cord-343791-0vykwml5	69	4	Gardasil	Gardasil	NNP
cord-343791-0vykwml5	69	5	,	,	,
cord-343791-0vykwml5	69	6	licensed	license	VBN
cord-343791-0vykwml5	69	7	by	by	IN
cord-343791-0vykwml5	69	8	Merck	Merck	NNP
cord-343791-0vykwml5	69	9	in	in	IN
cord-343791-0vykwml5	69	10	2006	2006	CD
cord-343791-0vykwml5	69	11	,	,	,
cord-343791-0vykwml5	69	12	is	be	VBZ
cord-343791-0vykwml5	69	13	a	a	DT
cord-343791-0vykwml5	69	14	vaccine	vaccine	NN
cord-343791-0vykwml5	69	15	against	against	IN
cord-343791-0vykwml5	69	16	HPV	hpv	NN
cord-343791-0vykwml5	69	17	that	that	WDT
cord-343791-0vykwml5	69	18	protects	protect	VBZ
cord-343791-0vykwml5	69	19	against	against	IN
cord-343791-0vykwml5	69	20	HPV	hpv	NN
cord-343791-0vykwml5	69	21	-	-	HYPH
cord-343791-0vykwml5	69	22	related	relate	VBN
cord-343791-0vykwml5	69	23	diseases	disease	NNS
cord-343791-0vykwml5	69	24	such	such	JJ
cord-343791-0vykwml5	69	25	as	as	IN
cord-343791-0vykwml5	69	26	cervical	cervical	JJ
cord-343791-0vykwml5	69	27	cancer	cancer	NN
cord-343791-0vykwml5	69	28	.	.	.
cord-343791-0vykwml5	70	1	In	in	IN
cord-343791-0vykwml5	70	2	1991	1991	CD
cord-343791-0vykwml5	70	3	,	,	,
cord-343791-0vykwml5	70	4	several	several	JJ
cord-343791-0vykwml5	70	5	laboratories	laboratory	NNS
cord-343791-0vykwml5	70	6	concurrently	concurrently	RB
cord-343791-0vykwml5	70	7	observed	observe	VBD
cord-343791-0vykwml5	70	8	that	that	IN
cord-343791-0vykwml5	70	9	recombinantly	recombinantly	RB
cord-343791-0vykwml5	70	10	expressed	express	VBD
cord-343791-0vykwml5	70	11	HPV	HPV	NNP
cord-343791-0vykwml5	70	12	L1	L1	NNP
cord-343791-0vykwml5	70	13	and	and	CC
cord-343791-0vykwml5	70	14	L2	L2	NNP
cord-343791-0vykwml5	70	15	virus	virus	NN
cord-343791-0vykwml5	70	16	capsid	capsid	NN
cord-343791-0vykwml5	70	17	proteins	protein	VBZ
cord-343791-0vykwml5	70	18	self	self	NN
cord-343791-0vykwml5	70	19	-	-	HYPH
cord-343791-0vykwml5	70	20	assembled	assemble	VBN
cord-343791-0vykwml5	70	21	into	into	IN
cord-343791-0vykwml5	70	22	VLPs	vlp	NNS
cord-343791-0vykwml5	70	23	resembling	resemble	VBG
cord-343791-0vykwml5	70	24	the	the	DT
cord-343791-0vykwml5	70	25	native	native	JJ
cord-343791-0vykwml5	70	26	virion	virion	NN
cord-343791-0vykwml5	70	27	structure	structure	NN
cord-343791-0vykwml5	70	28	.	.	.
cord-343791-0vykwml5	71	1	[	[	-LRB-
cord-343791-0vykwml5	71	2	23	23	CD
cord-343791-0vykwml5	71	3	]	]	-RRB-
cord-343791-0vykwml5	72	1	In	in	IN
cord-343791-0vykwml5	72	2	early	early	JJ
cord-343791-0vykwml5	72	3	1992	1992	CD
cord-343791-0vykwml5	72	4	,	,	,
cord-343791-0vykwml5	72	5	based	base	VBN
cord-343791-0vykwml5	72	6	on	on	IN
cord-343791-0vykwml5	72	7	this	this	DT
cord-343791-0vykwml5	72	8	observation	observation	NN
cord-343791-0vykwml5	72	9	,	,	,
cord-343791-0vykwml5	72	10	Merck	Merck	NNP
cord-343791-0vykwml5	72	11	Research	Research	NNP
cord-343791-0vykwml5	72	12	Laboratories	Laboratories	NNP
cord-343791-0vykwml5	72	13	(	(	-LRB-
cord-343791-0vykwml5	72	14	MRL	MRL	NNP
cord-343791-0vykwml5	72	15	)	)	-RRB-
cord-343791-0vykwml5	72	16	initiated	initiate	VBD
cord-343791-0vykwml5	72	17	an	an	DT
cord-343791-0vykwml5	72	18	HPV	HPV	NNP
cord-343791-0vykwml5	72	19	vaccine	vaccine	NN
cord-343791-0vykwml5	72	20	program	program	NN
cord-343791-0vykwml5	72	21	.	.	.
cord-343791-0vykwml5	73	1	At	at	IN
cord-343791-0vykwml5	73	2	the	the	DT
cord-343791-0vykwml5	73	3	time	time	NN
cord-343791-0vykwml5	73	4	,	,	,
cord-343791-0vykwml5	73	5	a	a	DT
cord-343791-0vykwml5	73	6	growing	grow	VBG
cord-343791-0vykwml5	73	7	number	number	NN
cord-343791-0vykwml5	73	8	of	of	IN
cord-343791-0vykwml5	73	9	HPV	hpv	NN
cord-343791-0vykwml5	73	10	genotypes	genotype	NNS
cord-343791-0vykwml5	73	11	were	be	VBD
cord-343791-0vykwml5	73	12	identified	identify	VBN
cord-343791-0vykwml5	73	13	and	and	CC
cord-343791-0vykwml5	73	14	associated	associate	VBN
cord-343791-0vykwml5	73	15	with	with	IN
cord-343791-0vykwml5	73	16	benign	benign	JJ
cord-343791-0vykwml5	73	17	genital	genital	JJ
cord-343791-0vykwml5	73	18	warts	wart	NNS
cord-343791-0vykwml5	73	19	and	and	CC
cord-343791-0vykwml5	73	20	or	or	CC
cord-343791-0vykwml5	73	21	precursor	precursor	NN
cord-343791-0vykwml5	73	22	lesions	lesion	NNS
cord-343791-0vykwml5	73	23	to	to	IN
cord-343791-0vykwml5	73	24	cervical	cervical	JJ
cord-343791-0vykwml5	73	25	cancer	cancer	NN
cord-343791-0vykwml5	73	26	.	.	.
cord-343791-0vykwml5	74	1	MRL	MRL	NNP
cord-343791-0vykwml5	74	2	devised	devise	VBD
cord-343791-0vykwml5	74	3	a	a	DT
cord-343791-0vykwml5	74	4	strategy	strategy	NN
cord-343791-0vykwml5	74	5	to	to	TO
cord-343791-0vykwml5	74	6	produce	produce	VB
cord-343791-0vykwml5	74	7	a	a	DT
cord-343791-0vykwml5	74	8	quadrivalent	quadrivalent	NN
cord-343791-0vykwml5	74	9	HPV	HPV	NNP
cord-343791-0vykwml5	74	10	L1	L1	NNP
cord-343791-0vykwml5	74	11	VLP	VLP	NNP
cord-343791-0vykwml5	74	12	that	that	WDT
cord-343791-0vykwml5	74	13	would	would	MD
cord-343791-0vykwml5	74	14	protect	protect	VB
cord-343791-0vykwml5	74	15	against	against	IN
cord-343791-0vykwml5	74	16	cervical	cervical	JJ
cord-343791-0vykwml5	74	17	cancers	cancer	NNS
cord-343791-0vykwml5	74	18	(	(	-LRB-
cord-343791-0vykwml5	74	19	caused	cause	VBN
cord-343791-0vykwml5	74	20	by	by	IN
cord-343791-0vykwml5	74	21	HPV16	hpv16	NN
cord-343791-0vykwml5	74	22	and	and	CC
cord-343791-0vykwml5	74	23	18	18	CD
cord-343791-0vykwml5	74	24	)	)	-RRB-
cord-343791-0vykwml5	74	25	as	as	RB
cord-343791-0vykwml5	74	26	well	well	RB
cord-343791-0vykwml5	74	27	as	as	IN
cord-343791-0vykwml5	74	28	genital	genital	JJ
cord-343791-0vykwml5	74	29	warts	wart	NNS
cord-343791-0vykwml5	74	30	(	(	-LRB-
cord-343791-0vykwml5	74	31	caused	cause	VBN
cord-343791-0vykwml5	74	32	by	by	IN
cord-343791-0vykwml5	74	33	HPV	HPV	NNP
cord-343791-0vykwml5	74	34	6	6	CD
cord-343791-0vykwml5	74	35	and	and	CC
cord-343791-0vykwml5	74	36	11	11	CD
cord-343791-0vykwml5	74	37	)	)	-RRB-
cord-343791-0vykwml5	74	38	.	.	.
cord-343791-0vykwml5	75	1	Several	several	JJ
cord-343791-0vykwml5	75	2	concurrent	concurrent	JJ
cord-343791-0vykwml5	75	3	studies	study	NNS
cord-343791-0vykwml5	75	4	in	in	IN
cord-343791-0vykwml5	75	5	the	the	DT
cord-343791-0vykwml5	75	6	1990s	1990	NNS
cord-343791-0vykwml5	75	7	were	be	VBD
cord-343791-0vykwml5	75	8	additionally	additionally	RB
cord-343791-0vykwml5	75	9	critical	critical	JJ
cord-343791-0vykwml5	75	10	to	to	IN
cord-343791-0vykwml5	75	11	the	the	DT
cord-343791-0vykwml5	75	12	success	success	NN
cord-343791-0vykwml5	75	13	of	of	IN
cord-343791-0vykwml5	75	14	HPV	hpv	NN
cord-343791-0vykwml5	75	15	vaccines	vaccine	NNS
cord-343791-0vykwml5	75	16	.	.	.
cord-343791-0vykwml5	76	1	One	one	CD
cord-343791-0vykwml5	76	2	important	important	JJ
cord-343791-0vykwml5	76	3	advancement	advancement	NN
cord-343791-0vykwml5	76	4	was	be	VBD
cord-343791-0vykwml5	76	5	the	the	DT
cord-343791-0vykwml5	76	6	development	development	NN
cord-343791-0vykwml5	76	7	of	of	IN
cord-343791-0vykwml5	76	8	an	an	DT
cord-343791-0vykwml5	76	9	in	in	FW
cord-343791-0vykwml5	76	10	vitro	vitro	FW
cord-343791-0vykwml5	76	11	method	method	NN
cord-343791-0vykwml5	76	12	of	of	IN
cord-343791-0vykwml5	76	13	producing	produce	VBG
cord-343791-0vykwml5	76	14	HPV	HPV	NNP
cord-343791-0vykwml5	76	15	virions	virion	NNS
cord-343791-0vykwml5	76	16	.	.	.
cord-343791-0vykwml5	77	1	The	the	DT
cord-343791-0vykwml5	77	2	HPV	HPV	NNP
cord-343791-0vykwml5	77	3	lifecycle	lifecycle	NN
cord-343791-0vykwml5	77	4	is	be	VBZ
cord-343791-0vykwml5	77	5	linked	link	VBN
cord-343791-0vykwml5	77	6	to	to	IN
cord-343791-0vykwml5	77	7	human	human	JJ
cord-343791-0vykwml5	77	8	epithelial	epithelial	JJ
cord-343791-0vykwml5	77	9	tissue	tissue	NN
cord-343791-0vykwml5	77	10	differentiation	differentiation	NN
cord-343791-0vykwml5	77	11	which	which	WDT
cord-343791-0vykwml5	77	12	is	be	VBZ
cord-343791-0vykwml5	77	13	difficult	difficult	JJ
cord-343791-0vykwml5	77	14	to	to	TO
cord-343791-0vykwml5	77	15	achieve	achieve	VB
cord-343791-0vykwml5	77	16	in	in	IN
cord-343791-0vykwml5	77	17	vitro	vitro	FW
cord-343791-0vykwml5	77	18	.	.	.
cord-343791-0vykwml5	78	1	Kreider	Kreider	NNP
cord-343791-0vykwml5	78	2	et	et	NNP
cord-343791-0vykwml5	78	3	al	al	NNP
cord-343791-0vykwml5	78	4	.	.	.
cord-343791-0vykwml5	79	1	overcame	overcome	VBD
cord-343791-0vykwml5	79	2	this	this	DT
cord-343791-0vykwml5	79	3	challenge	challenge	NN
cord-343791-0vykwml5	79	4	was	be	VBD
cord-343791-0vykwml5	79	5	overcome	overcome	VBN
cord-343791-0vykwml5	79	6	by	by	IN
cord-343791-0vykwml5	79	7	developing	develop	VBG
cord-343791-0vykwml5	79	8	a	a	DT
cord-343791-0vykwml5	79	9	complex	complex	JJ
cord-343791-0vykwml5	79	10	xenograft	xenograft	NN
cord-343791-0vykwml5	79	11	model	model	NN
cord-343791-0vykwml5	79	12	in	in	IN
cord-343791-0vykwml5	79	13	which	which	WDT
cord-343791-0vykwml5	79	14	human	human	JJ
cord-343791-0vykwml5	79	15	foreskin	foreskin	NN
cord-343791-0vykwml5	79	16	epithelial	epithelial	JJ
cord-343791-0vykwml5	79	17	tissue	tissue	NN
cord-343791-0vykwml5	79	18	was	be	VBD
cord-343791-0vykwml5	79	19	infected	infect	VBN
cord-343791-0vykwml5	79	20	with	with	IN
cord-343791-0vykwml5	79	21	HPV	hpv	NN
cord-343791-0vykwml5	79	22	11	11	CD
cord-343791-0vykwml5	79	23	and	and	CC
cord-343791-0vykwml5	79	24	grown	grow	VBN
cord-343791-0vykwml5	79	25	under	under	IN
cord-343791-0vykwml5	79	26	the	the	DT
cord-343791-0vykwml5	79	27	renal	renal	JJ
cord-343791-0vykwml5	79	28	capsule	capsule	NN
cord-343791-0vykwml5	79	29	of	of	IN
cord-343791-0vykwml5	79	30	athymic	athymic	JJ
cord-343791-0vykwml5	79	31	mice	mouse	NNS
cord-343791-0vykwml5	79	32	.	.	.
cord-343791-0vykwml5	80	1	This	this	DT
cord-343791-0vykwml5	80	2	method	method	NN
cord-343791-0vykwml5	80	3	allowed	allow	VBN
cord-343791-0vykwml5	80	4	for	for	IN
cord-343791-0vykwml5	80	5	the	the	DT
cord-343791-0vykwml5	80	6	production	production	NN
cord-343791-0vykwml5	80	7	of	of	IN
cord-343791-0vykwml5	80	8	infectious	infectious	JJ
cord-343791-0vykwml5	80	9	HPV	HPV	NNP
cord-343791-0vykwml5	80	10	11	11	CD
cord-343791-0vykwml5	80	11	.	.	.
cord-343791-0vykwml5	81	1	[	[	-LRB-
cord-343791-0vykwml5	81	2	23	23	CD
cord-343791-0vykwml5	81	3	]	]	-RRB-
cord-343791-0vykwml5	82	1	In	in	IN
cord-343791-0vykwml5	82	2	1995	1995	CD
cord-343791-0vykwml5	82	3	,	,	,
cord-343791-0vykwml5	82	4	animal	animal	NN
cord-343791-0vykwml5	82	5	challenge	challenge	NN
cord-343791-0vykwml5	82	6	studies	study	NNS
cord-343791-0vykwml5	82	7	were	be	VBD
cord-343791-0vykwml5	82	8	published	publish	VBN
cord-343791-0vykwml5	82	9	that	that	WDT
cord-343791-0vykwml5	82	10	continued	continue	VBD
cord-343791-0vykwml5	82	11	to	to	TO
cord-343791-0vykwml5	82	12	advance	advance	VB
cord-343791-0vykwml5	82	13	HPV	HPV	NNP
cord-343791-0vykwml5	82	14	vaccines	vaccine	NNS
cord-343791-0vykwml5	82	15	.	.	.
cord-343791-0vykwml5	83	1	Two	two	CD
cord-343791-0vykwml5	83	2	studies	study	NNS
cord-343791-0vykwml5	83	3	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	83	4	measurable	measurable	JJ
cord-343791-0vykwml5	83	5	serum	serum	NN
cord-343791-0vykwml5	83	6	antibody	antibody	NN
cord-343791-0vykwml5	83	7	responses	response	NNS
cord-343791-0vykwml5	83	8	to	to	IN
cord-343791-0vykwml5	83	9	VLP	VLP	NNP
cord-343791-0vykwml5	83	10	immunization	immunization	NN
cord-343791-0vykwml5	83	11	and	and	CC
cord-343791-0vykwml5	83	12	subsequent	subsequent	JJ
cord-343791-0vykwml5	83	13	protection	protection	NN
cord-343791-0vykwml5	83	14	in	in	IN
cord-343791-0vykwml5	83	15	later	later	JJ
cord-343791-0vykwml5	83	16	challenges	challenge	NNS
cord-343791-0vykwml5	83	17	.	.	.
cord-343791-0vykwml5	84	1	[	[	-LRB-
cord-343791-0vykwml5	84	2	23	23	CD
cord-343791-0vykwml5	84	3	]	]	-RRB-
cord-343791-0vykwml5	85	1	The	the	DT
cord-343791-0vykwml5	85	2	third	third	NN
cord-343791-0vykwml5	85	3	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	85	4	the	the	DT
cord-343791-0vykwml5	85	5	importance	importance	NN
cord-343791-0vykwml5	85	6	of	of	IN
cord-343791-0vykwml5	85	7	maintaining	maintain	VBG
cord-343791-0vykwml5	85	8	the	the	DT
cord-343791-0vykwml5	85	9	native	native	JJ
cord-343791-0vykwml5	85	10	VLP	VLP	NNP
cord-343791-0vykwml5	85	11	structure	structure	NN
cord-343791-0vykwml5	85	12	for	for	IN
cord-343791-0vykwml5	85	13	optimal	optimal	JJ
cord-343791-0vykwml5	85	14	vaccine	vaccine	NN
cord-343791-0vykwml5	85	15	efficacy	efficacy	NN
cord-343791-0vykwml5	85	16	.	.	.
cord-343791-0vykwml5	86	1	[	[	-LRB-
cord-343791-0vykwml5	86	2	24	24	CD
cord-343791-0vykwml5	86	3	]	]	-RRB-
cord-343791-0vykwml5	87	1	Another	another	DT
cord-343791-0vykwml5	87	2	key	key	JJ
cord-343791-0vykwml5	87	3	contribution	contribution	NN
cord-343791-0vykwml5	87	4	to	to	IN
cord-343791-0vykwml5	87	5	the	the	DT
cord-343791-0vykwml5	87	6	success	success	NN
cord-343791-0vykwml5	87	7	of	of	IN
cord-343791-0vykwml5	87	8	MRL	MRL	NNP
cord-343791-0vykwml5	87	9	's	's	POS
cord-343791-0vykwml5	87	10	HPV	HPV	NNP
cord-343791-0vykwml5	87	11	vaccine	vaccine	NN
cord-343791-0vykwml5	87	12	came	come	VBD
cord-343791-0vykwml5	87	13	from	from	IN
cord-343791-0vykwml5	87	14	work	work	NN
cord-343791-0vykwml5	87	15	developing	develop	VBG
cord-343791-0vykwml5	87	16	a	a	DT
cord-343791-0vykwml5	87	17	manufacturing	manufacturing	NN
cord-343791-0vykwml5	87	18	process	process	NN
cord-343791-0vykwml5	87	19	for	for	IN
cord-343791-0vykwml5	87	20	HBsAg	hbsag	ADD
cord-343791-0vykwml5	87	21	production	production	NN
cord-343791-0vykwml5	87	22	in	in	IN
cord-343791-0vykwml5	87	23	Saccharomyces	Saccharomyces	NNP
cord-343791-0vykwml5	87	24	cerevisiae	cerevisiae	NNS
cord-343791-0vykwml5	87	25	.	.	.
cord-343791-0vykwml5	88	1	It	-PRON-	PRP
cord-343791-0vykwml5	88	2	provided	provide	VBD
cord-343791-0vykwml5	88	3	a	a	DT
cord-343791-0vykwml5	88	4	foundation	foundation	NN
cord-343791-0vykwml5	88	5	for	for	IN
cord-343791-0vykwml5	88	6	the	the	DT
cord-343791-0vykwml5	88	7	development	development	NN
cord-343791-0vykwml5	88	8	of	of	IN
cord-343791-0vykwml5	88	9	methods	method	NNS
cord-343791-0vykwml5	88	10	to	to	TO
cord-343791-0vykwml5	88	11	design	design	VB
cord-343791-0vykwml5	88	12	,	,	,
cord-343791-0vykwml5	88	13	express	express	NNP
cord-343791-0vykwml5	88	14	,	,	,
cord-343791-0vykwml5	88	15	and	and	CC
cord-343791-0vykwml5	88	16	purify	purify	VB
cord-343791-0vykwml5	88	17	large	large	JJ
cord-343791-0vykwml5	88	18	amounts	amount	NNS
cord-343791-0vykwml5	88	19	of	of	IN
cord-343791-0vykwml5	88	20	HPV	HPV	NNP
cord-343791-0vykwml5	88	21	VLPs	vlp	NNS
cord-343791-0vykwml5	88	22	.	.	.
cord-343791-0vykwml5	89	1	[	[	-LRB-
cord-343791-0vykwml5	89	2	23	23	CD
cord-343791-0vykwml5	89	3	]	]	-RRB-
cord-343791-0vykwml5	90	1	In	in	IN
cord-343791-0vykwml5	90	2	1997	1997	CD
cord-343791-0vykwml5	90	3	,	,	,
cord-343791-0vykwml5	90	4	HPV	hpv	NN
cord-343791-0vykwml5	90	5	11	11	CD
cord-343791-0vykwml5	90	6	L1	L1	NNP
cord-343791-0vykwml5	90	7	VLPs	vlp	NNS
cord-343791-0vykwml5	90	8	were	be	VBD
cord-343791-0vykwml5	90	9	evaluated	evaluate	VBN
cord-343791-0vykwml5	90	10	for	for	IN
cord-343791-0vykwml5	90	11	the	the	DT
cord-343791-0vykwml5	90	12	first	first	JJ
cord-343791-0vykwml5	90	13	time	time	NN
cord-343791-0vykwml5	90	14	in	in	IN
cord-343791-0vykwml5	90	15	humans	human	NNS
cord-343791-0vykwml5	90	16	as	as	IN
cord-343791-0vykwml5	90	17	a	a	DT
cord-343791-0vykwml5	90	18	monovalent	monovalent	JJ
cord-343791-0vykwml5	90	19	vaccine	vaccine	NN
cord-343791-0vykwml5	90	20	during	during	IN
cord-343791-0vykwml5	90	21	a	a	DT
cord-343791-0vykwml5	90	22	Phase	phase	NN
cord-343791-0vykwml5	91	1	I	-PRON-	PRP
cord-343791-0vykwml5	91	2	clinical	clinical	JJ
cord-343791-0vykwml5	91	3	trial	trial	NN
cord-343791-0vykwml5	91	4	to	to	TO
cord-343791-0vykwml5	91	5	demonstrate	demonstrate	VB
cord-343791-0vykwml5	91	6	safety	safety	NN
cord-343791-0vykwml5	91	7	and	and	CC
cord-343791-0vykwml5	91	8	immunogenicity	immunogenicity	NN
cord-343791-0vykwml5	91	9	.	.	.
cord-343791-0vykwml5	92	1	The	the	DT
cord-343791-0vykwml5	92	2	monovalent	monovalent	JJ
cord-343791-0vykwml5	92	3	vaccine	vaccine	NN
cord-343791-0vykwml5	92	4	was	be	VBD
cord-343791-0vykwml5	92	5	chosen	choose	VBN
cord-343791-0vykwml5	92	6	owing	owe	VBG
cord-343791-0vykwml5	92	7	to	to	IN
cord-343791-0vykwml5	92	8	the	the	DT
cord-343791-0vykwml5	92	9	availability	availability	NN
cord-343791-0vykwml5	92	10	of	of	IN
cord-343791-0vykwml5	92	11	robust	robust	JJ
cord-343791-0vykwml5	92	12	models	model	NNS
cord-343791-0vykwml5	92	13	for	for	IN
cord-343791-0vykwml5	92	14	the	the	DT
cord-343791-0vykwml5	92	15	evaluation	evaluation	NN
cord-343791-0vykwml5	92	16	of	of	IN
cord-343791-0vykwml5	92	17	immunogenicity	immunogenicity	NN
cord-343791-0vykwml5	92	18	,	,	,
cord-343791-0vykwml5	92	19	and	and	CC
cord-343791-0vykwml5	92	20	because	because	IN
cord-343791-0vykwml5	92	21	models	model	NNS
cord-343791-0vykwml5	92	22	for	for	IN
cord-343791-0vykwml5	92	23	the	the	DT
cord-343791-0vykwml5	92	24	other	other	JJ
cord-343791-0vykwml5	92	25	three	three	CD
cord-343791-0vykwml5	92	26	HPV	hpv	NN
cord-343791-0vykwml5	92	27	types	type	NNS
cord-343791-0vykwml5	92	28	had	have	VBD
cord-343791-0vykwml5	92	29	not	not	RB
cord-343791-0vykwml5	92	30	yet	yet	RB
cord-343791-0vykwml5	92	31	been	be	VBN
cord-343791-0vykwml5	92	32	developed	develop	VBN
cord-343791-0vykwml5	92	33	.	.	.
cord-343791-0vykwml5	93	1	The	the	DT
cord-343791-0vykwml5	93	2	Phase	phase	NN
cord-343791-0vykwml5	93	3	1	1	CD
cord-343791-0vykwml5	93	4	study	study	NN
cord-343791-0vykwml5	93	5	outcomes	outcome	NNS
cord-343791-0vykwml5	93	6	were	be	VBD
cord-343791-0vykwml5	93	7	promising	promise	VBG
cord-343791-0vykwml5	93	8	,	,	,
cord-343791-0vykwml5	93	9	with	with	IN
cord-343791-0vykwml5	93	10	no	no	DT
cord-343791-0vykwml5	93	11	reported	reported	JJ
cord-343791-0vykwml5	93	12	significant	significant	JJ
cord-343791-0vykwml5	93	13	adverse	adverse	JJ
cord-343791-0vykwml5	93	14	effects	effect	NNS
cord-343791-0vykwml5	93	15	.	.	.
cord-343791-0vykwml5	94	1	A	a	DT
cord-343791-0vykwml5	94	2	second	second	JJ
cord-343791-0vykwml5	94	3	study	study	NN
cord-343791-0vykwml5	94	4	tested	test	VBD
cord-343791-0vykwml5	94	5	the	the	DT
cord-343791-0vykwml5	94	6	ability	ability	NN
cord-343791-0vykwml5	94	7	of	of	IN
cord-343791-0vykwml5	94	8	monovalent	monovalent	NN
cord-343791-0vykwml5	94	9	HPV	HPV	NNP
cord-343791-0vykwml5	94	10	16	16	CD
cord-343791-0vykwml5	94	11	L1	L1	NNP
cord-343791-0vykwml5	94	12	VLP	VLP	NNP
cord-343791-0vykwml5	94	13	efficacy	efficacy	NN
cord-343791-0vykwml5	94	14	in	in	IN
cord-343791-0vykwml5	94	15	preventing	prevent	VBG
cord-343791-0vykwml5	94	16	HPV	hpv	NN
cord-343791-0vykwml5	94	17	infection	infection	NN
cord-343791-0vykwml5	94	18	,	,	,
cord-343791-0vykwml5	94	19	providing	provide	VBG
cord-343791-0vykwml5	94	20	the	the	DT
cord-343791-0vykwml5	94	21	first	first	JJ
cord-343791-0vykwml5	94	22	demonstration	demonstration	NN
cord-343791-0vykwml5	94	23	that	that	DT
cord-343791-0vykwml5	94	24	vaccination	vaccination	NN
cord-343791-0vykwml5	94	25	with	with	IN
cord-343791-0vykwml5	94	26	HPV	HPV	NNP
cord-343791-0vykwml5	94	27	VLPs	vlp	NNS
cord-343791-0vykwml5	94	28	could	could	MD
cord-343791-0vykwml5	94	29	prevent	prevent	VB
cord-343791-0vykwml5	94	30	disease	disease	NN
cord-343791-0vykwml5	94	31	.	.	.
cord-343791-0vykwml5	95	1	These	these	DT
cord-343791-0vykwml5	95	2	favorable	favorable	JJ
cord-343791-0vykwml5	95	3	results	result	NNS
cord-343791-0vykwml5	95	4	supported	support	VBD
cord-343791-0vykwml5	95	5	the	the	DT
cord-343791-0vykwml5	95	6	development	development	NN
cord-343791-0vykwml5	95	7	of	of	IN
cord-343791-0vykwml5	95	8	the	the	DT
cord-343791-0vykwml5	95	9	multivalent	multivalent	JJ
cord-343791-0vykwml5	95	10	vaccine	vaccine	NN
cord-343791-0vykwml5	95	11	and	and	CC
cord-343791-0vykwml5	95	12	spurred	spur	VBD
cord-343791-0vykwml5	95	13	the	the	DT
cord-343791-0vykwml5	95	14	advancement	advancement	NN
cord-343791-0vykwml5	95	15	of	of	IN
cord-343791-0vykwml5	95	16	the	the	DT
cord-343791-0vykwml5	95	17	program	program	NN
cord-343791-0vykwml5	95	18	.	.	.
cord-343791-0vykwml5	96	1	In	in	IN
cord-343791-0vykwml5	96	2	2006	2006	CD
cord-343791-0vykwml5	96	3	,	,	,
cord-343791-0vykwml5	96	4	after	after	IN
cord-343791-0vykwml5	96	5	impressive	impressive	JJ
cord-343791-0vykwml5	96	6	efficacy	efficacy	NN
cord-343791-0vykwml5	96	7	data	datum	NNS
cord-343791-0vykwml5	96	8	and	and	CC
cord-343791-0vykwml5	96	9	an	an	DT
cord-343791-0vykwml5	96	10	acceptable	acceptable	JJ
cord-343791-0vykwml5	96	11	safety	safety	NN
cord-343791-0vykwml5	96	12	profile	profile	NN
cord-343791-0vykwml5	96	13	,	,	,
cord-343791-0vykwml5	96	14	the	the	DT
cord-343791-0vykwml5	96	15	first	first	JJ
cord-343791-0vykwml5	96	16	HPV	HPV	NNP
cord-343791-0vykwml5	96	17	VLP	VLP	NNP
cord-343791-0vykwml5	96	18	vaccine	vaccine	NN
cord-343791-0vykwml5	96	19	,	,	,
cord-343791-0vykwml5	96	20	Gardasil	Gardasil	NNP
cord-343791-0vykwml5	96	21	,	,	,
cord-343791-0vykwml5	96	22	was	be	VBD
cord-343791-0vykwml5	96	23	licensed	license	VBN
cord-343791-0vykwml5	96	24	(	(	-LRB-
cord-343791-0vykwml5	96	25	see	see	VB
cord-343791-0vykwml5	96	26	timeline	timeline	NN
cord-343791-0vykwml5	96	27	in	in	IN
cord-343791-0vykwml5	96	28	Figure	Figure	NNP
cord-343791-0vykwml5	96	29	3	3	CD
cord-343791-0vykwml5	96	30	)	)	-RRB-
cord-343791-0vykwml5	96	31	.	.	.
cord-343791-0vykwml5	97	1	[	[	-LRB-
cord-343791-0vykwml5	97	2	23	23	CD
cord-343791-0vykwml5	97	3	,	,	,
cord-343791-0vykwml5	97	4	25	25	CD
cord-343791-0vykwml5	97	5	]	]	-RRB-
cord-343791-0vykwml5	98	1	Another	another	DT
cord-343791-0vykwml5	98	2	HPV	HPV	NNP
cord-343791-0vykwml5	98	3	VLP	VLP	NNP
cord-343791-0vykwml5	98	4	human	human	JJ
cord-343791-0vykwml5	98	5	vaccine	vaccine	NN
cord-343791-0vykwml5	98	6	for	for	IN
cord-343791-0vykwml5	98	7	the	the	DT
cord-343791-0vykwml5	98	8	prevention	prevention	NN
cord-343791-0vykwml5	98	9	of	of	IN
cord-343791-0vykwml5	98	10	cervical	cervical	JJ
cord-343791-0vykwml5	98	11	cancer	cancer	NN
cord-343791-0vykwml5	98	12	,	,	,
cord-343791-0vykwml5	98	13	Cervarix	Cervarix	NNP
cord-343791-0vykwml5	98	14	,	,	,
cord-343791-0vykwml5	98	15	was	be	VBD
cord-343791-0vykwml5	98	16	developed	develop	VBN
cord-343791-0vykwml5	98	17	by	by	IN
cord-343791-0vykwml5	98	18	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-343791-0vykwml5	98	19	and	and	CC
cord-343791-0vykwml5	98	20	licensed	license	VBN
cord-343791-0vykwml5	98	21	in	in	IN
cord-343791-0vykwml5	98	22	the	the	DT
cord-343791-0vykwml5	98	23	United	United	NNP
cord-343791-0vykwml5	98	24	States	States	NNP
cord-343791-0vykwml5	98	25	in	in	IN
cord-343791-0vykwml5	98	26	2009	2009	CD
cord-343791-0vykwml5	98	27	.	.	.
cord-343791-0vykwml5	99	1	This	this	DT
cord-343791-0vykwml5	99	2	vaccine	vaccine	NN
cord-343791-0vykwml5	99	3	includes	include	VBZ
cord-343791-0vykwml5	99	4	HPV	hpv	NN
cord-343791-0vykwml5	99	5	types	type	NNS
cord-343791-0vykwml5	99	6	16	16	CD
cord-343791-0vykwml5	99	7	and	and	CC
cord-343791-0vykwml5	99	8	18	18	CD
cord-343791-0vykwml5	99	9	and	and	CC
cord-343791-0vykwml5	99	10	has	have	VBZ
cord-343791-0vykwml5	99	11	been	be	VBN
cord-343791-0vykwml5	99	12	produced	produce	VBN
cord-343791-0vykwml5	99	13	using	use	VBG
cord-343791-0vykwml5	99	14	insect	insect	NN
cord-343791-0vykwml5	99	15	cells	cell	NNS
cord-343791-0vykwml5	99	16	infected	infect	VBN
cord-343791-0vykwml5	99	17	with	with	IN
cord-343791-0vykwml5	99	18	recombinant	recombinant	JJ
cord-343791-0vykwml5	99	19	baculovirus	baculovirus	NN
cord-343791-0vykwml5	99	20	.	.	.
cord-343791-0vykwml5	100	1	[	[	-LRB-
cord-343791-0vykwml5	100	2	26	26	CD
cord-343791-0vykwml5	100	3	]	]	-RRB-
cord-343791-0vykwml5	100	4	Cervarix	Cervarix	NNP
cord-343791-0vykwml5	100	5	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	100	6	a	a	DT
cord-343791-0vykwml5	100	7	90.4	90.4	CD
cord-343791-0vykwml5	100	8	%	%	NN
cord-343791-0vykwml5	100	9	efficacy	efficacy	NN
cord-343791-0vykwml5	100	10	against	against	IN
cord-343791-0vykwml5	100	11	cervical	cervical	JJ
cord-343791-0vykwml5	100	12	intraepithelial	intraepithelial	JJ
cord-343791-0vykwml5	100	13	neoplasia	neoplasia	NN
cord-343791-0vykwml5	100	14	lesions	lesion	NNS
cord-343791-0vykwml5	100	15	containing	contain	VBG
cord-343791-0vykwml5	100	16	HPV	HPV	NNP
cord-343791-0vykwml5	100	17	16	16	CD
cord-343791-0vykwml5	100	18	and	and	CC
cord-343791-0vykwml5	100	19	18	18	CD
cord-343791-0vykwml5	100	20	and	and	CC
cord-343791-0vykwml5	100	21	indicated	indicate	VBD
cord-343791-0vykwml5	100	22	cross	cross	NN
cord-343791-0vykwml5	100	23	-	-	NN
cord-343791-0vykwml5	100	24	protection	protection	NN
cord-343791-0vykwml5	100	25	with	with	IN
cord-343791-0vykwml5	100	26	the	the	DT
cord-343791-0vykwml5	100	27	HPV	HPV	NNP
cord-343791-0vykwml5	100	28	types	type	NNS
cord-343791-0vykwml5	100	29	31	31	CD
cord-343791-0vykwml5	100	30	and	and	CC
cord-343791-0vykwml5	100	31	45	45	CD
cord-343791-0vykwml5	100	32	,	,	,
cord-343791-0vykwml5	100	33	leading	lead	VBG
cord-343791-0vykwml5	100	34	to	to	IN
cord-343791-0vykwml5	100	35	the	the	DT
cord-343791-0vykwml5	100	36	protection	protection	NN
cord-343791-0vykwml5	100	37	against	against	IN
cord-343791-0vykwml5	100	38	80	80	CD
cord-343791-0vykwml5	100	39	%	%	NN
cord-343791-0vykwml5	100	40	of	of	IN
cord-343791-0vykwml5	100	41	cervical	cervical	JJ
cord-343791-0vykwml5	100	42	cancers	cancer	NNS
cord-343791-0vykwml5	100	43	.	.	.
cord-343791-0vykwml5	101	1	[	[	-LRB-
cord-343791-0vykwml5	101	2	27	27	CD
cord-343791-0vykwml5	101	3	]	]	-RRB-
cord-343791-0vykwml5	101	4	Hecolin	Hecolin	NNP
cord-343791-0vykwml5	101	5	(	(	-LRB-
cord-343791-0vykwml5	101	6	Xiamen	Xiamen	NNP
cord-343791-0vykwml5	101	7	Innovax	Innovax	NNP
cord-343791-0vykwml5	101	8	Biotech	Biotech	NNP
cord-343791-0vykwml5	101	9	)	)	-RRB-
cord-343791-0vykwml5	101	10	,	,	,
cord-343791-0vykwml5	101	11	a	a	DT
cord-343791-0vykwml5	101	12	recombinant	recombinant	JJ
cord-343791-0vykwml5	101	13	VLP	VLP	NNP
cord-343791-0vykwml5	101	14	-	-	HYPH
cord-343791-0vykwml5	101	15	based	base	VBN
cord-343791-0vykwml5	101	16	vaccine	vaccine	NN
cord-343791-0vykwml5	101	17	for	for	IN
cord-343791-0vykwml5	101	18	prophylactic	prophylactic	JJ
cord-343791-0vykwml5	101	19	[	[	-LRB-
cord-343791-0vykwml5	101	20	11	11	CD
cord-343791-0vykwml5	101	21	]	]	-RRB-
cord-343791-0vykwml5	102	1	Copyright	copyright	NN
cord-343791-0vykwml5	102	2	2001	2001	CD
cord-343791-0vykwml5	102	3	,	,	,
cord-343791-0vykwml5	102	4	AAAS	AAAS	NNP
cord-343791-0vykwml5	102	5	.	.	.
cord-343791-0vykwml5	103	1	(	(	-LRB-
cord-343791-0vykwml5	103	2	A	a	DT
cord-343791-0vykwml5	103	3	,	,	,
cord-343791-0vykwml5	103	4	right	right	JJ
cord-343791-0vykwml5	103	5	)	)	-RRB-
cord-343791-0vykwml5	103	6	Adapted	adapt	VBN
cord-343791-0vykwml5	103	7	with	with	IN
cord-343791-0vykwml5	103	8	permission	permission	NN
cord-343791-0vykwml5	103	9	.	.	.
cord-343791-0vykwml5	104	1	[	[	-LRB-
cord-343791-0vykwml5	104	2	12	12	CD
cord-343791-0vykwml5	104	3	]	]	-RRB-
cord-343791-0vykwml5	105	1	Copyright	copyright	NN
cord-343791-0vykwml5	105	2	2002	2002	CD
cord-343791-0vykwml5	105	3	,	,	,
cord-343791-0vykwml5	105	4	National	National	NNP
cord-343791-0vykwml5	105	5	Academy	Academy	NNP
cord-343791-0vykwml5	105	6	of	of	IN
cord-343791-0vykwml5	105	7	Science	Science	NNP
cord-343791-0vykwml5	105	8	.	.	.
cord-343791-0vykwml5	106	1	(	(	-LRB-
cord-343791-0vykwml5	106	2	B	b	NN
cord-343791-0vykwml5	106	3	,	,	,
cord-343791-0vykwml5	106	4	left	leave	VBN
cord-343791-0vykwml5	106	5	)	)	-RRB-
cord-343791-0vykwml5	106	6	Adapted	adapt	VBN
cord-343791-0vykwml5	106	7	with	with	IN
cord-343791-0vykwml5	106	8	permission	permission	NN
cord-343791-0vykwml5	106	9	.	.	.
cord-343791-0vykwml5	107	1	[	[	-LRB-
cord-343791-0vykwml5	107	2	13	13	CD
cord-343791-0vykwml5	107	3	]	]	-RRB-
cord-343791-0vykwml5	108	1	Copyright	copyright	NN
cord-343791-0vykwml5	108	2	2013	2013	CD
cord-343791-0vykwml5	108	3	,	,	,
cord-343791-0vykwml5	108	4	American	American	NNP
cord-343791-0vykwml5	108	5	Chemical	Chemical	NNP
cord-343791-0vykwml5	108	6	Society	Society	NNP
cord-343791-0vykwml5	108	7	.	.	.
cord-343791-0vykwml5	109	1	(	(	-LRB-
cord-343791-0vykwml5	109	2	B	b	NN
cord-343791-0vykwml5	109	3	,	,	,
cord-343791-0vykwml5	109	4	right	right	RB
cord-343791-0vykwml5	109	5	)	)	-RRB-
cord-343791-0vykwml5	109	6	Adapted	adapt	VBN
cord-343791-0vykwml5	109	7	with	with	IN
cord-343791-0vykwml5	109	8	permission	permission	NN
cord-343791-0vykwml5	109	9	.	.	.
cord-343791-0vykwml5	110	1	[	[	-LRB-
cord-343791-0vykwml5	110	2	14	14	CD
cord-343791-0vykwml5	110	3	]	]	-RRB-
cord-343791-0vykwml5	110	4	(	(	-LRB-
cord-343791-0vykwml5	110	5	C	C	NNP
cord-343791-0vykwml5	110	6	,	,	,
cord-343791-0vykwml5	110	7	left	leave	VBN
cord-343791-0vykwml5	110	8	)	)	-RRB-
cord-343791-0vykwml5	110	9	Adapted	adapt	VBN
cord-343791-0vykwml5	110	10	with	with	IN
cord-343791-0vykwml5	110	11	permission	permission	NN
cord-343791-0vykwml5	110	12	.	.	.
cord-343791-0vykwml5	111	1	[	[	-LRB-
cord-343791-0vykwml5	111	2	15	15	CD
cord-343791-0vykwml5	111	3	]	]	-RRB-
cord-343791-0vykwml5	111	4	Copyright	copyright	NN
cord-343791-0vykwml5	111	5	2014	2014	CD
cord-343791-0vykwml5	111	6	,	,	,
cord-343791-0vykwml5	111	7	Elsevier	Elsevier	NNP
cord-343791-0vykwml5	111	8	.	.	.
cord-343791-0vykwml5	112	1	(	(	-LRB-
cord-343791-0vykwml5	112	2	C	C	NNP
cord-343791-0vykwml5	112	3	,	,	,
cord-343791-0vykwml5	112	4	right	right	UH
cord-343791-0vykwml5	112	5	)	)	-RRB-
cord-343791-0vykwml5	112	6	Adapted	adapt	VBN
cord-343791-0vykwml5	112	7	with	with	IN
cord-343791-0vykwml5	112	8	permission	permission	NN
cord-343791-0vykwml5	112	9	.	.	.
cord-343791-0vykwml5	113	1	[	[	-LRB-
cord-343791-0vykwml5	113	2	16	16	CD
cord-343791-0vykwml5	113	3	]	]	-RRB-
cord-343791-0vykwml5	113	4	use	use	VBP
cord-343791-0vykwml5	113	5	against	against	IN
cord-343791-0vykwml5	113	6	hepatitis	hepatitis	NN
cord-343791-0vykwml5	113	7	E	e	NN
cord-343791-0vykwml5	113	8	virus	virus	NN
cord-343791-0vykwml5	113	9	infection	infection	NN
cord-343791-0vykwml5	113	10	,	,	,
cord-343791-0vykwml5	113	11	was	be	VBD
cord-343791-0vykwml5	113	12	licensed	license	VBN
cord-343791-0vykwml5	113	13	in	in	IN
cord-343791-0vykwml5	113	14	China	China	NNP
cord-343791-0vykwml5	113	15	in	in	IN
cord-343791-0vykwml5	113	16	2011	2011	CD
cord-343791-0vykwml5	113	17	.	.	.
cord-343791-0vykwml5	114	1	[	[	-LRB-
cord-343791-0vykwml5	114	2	28	28	CD
cord-343791-0vykwml5	114	3	]	]	-RRB-
cord-343791-0vykwml5	115	1	In	in	IN
cord-343791-0vykwml5	115	2	the	the	DT
cord-343791-0vykwml5	115	3	past	past	JJ
cord-343791-0vykwml5	115	4	decade	decade	NN
cord-343791-0vykwml5	115	5	,	,	,
cord-343791-0vykwml5	115	6	VLP	VLP	NNP
cord-343791-0vykwml5	115	7	vaccines	vaccine	NNS
cord-343791-0vykwml5	115	8	have	have	VBP
cord-343791-0vykwml5	115	9	played	play	VBN
cord-343791-0vykwml5	115	10	a	a	DT
cord-343791-0vykwml5	115	11	critical	critical	JJ
cord-343791-0vykwml5	115	12	role	role	NN
cord-343791-0vykwml5	115	13	in	in	IN
cord-343791-0vykwml5	115	14	the	the	DT
cord-343791-0vykwml5	115	15	improvement	improvement	NN
cord-343791-0vykwml5	115	16	of	of	IN
cord-343791-0vykwml5	115	17	human	human	JJ
cord-343791-0vykwml5	115	18	health	health	NN
cord-343791-0vykwml5	115	19	and	and	CC
cord-343791-0vykwml5	115	20	continue	continue	VB
cord-343791-0vykwml5	115	21	to	to	TO
cord-343791-0vykwml5	115	22	be	be	VB
cord-343791-0vykwml5	115	23	applied	apply	VBN
cord-343791-0vykwml5	115	24	to	to	IN
cord-343791-0vykwml5	115	25	new	new	JJ
cord-343791-0vykwml5	115	26	diseases	disease	NNS
cord-343791-0vykwml5	115	27	.	.	.
cord-343791-0vykwml5	116	1	VLP	VLP	NNP
cord-343791-0vykwml5	116	2	-	-	HYPH
cord-343791-0vykwml5	116	3	based	base	VBN
cord-343791-0vykwml5	116	4	vaccines	vaccine	NNS
cord-343791-0vykwml5	116	5	are	be	VBP
cord-343791-0vykwml5	116	6	currently	currently	RB
cord-343791-0vykwml5	116	7	in	in	IN
cord-343791-0vykwml5	116	8	clinical	clinical	JJ
cord-343791-0vykwml5	116	9	trials	trial	NNS
cord-343791-0vykwml5	116	10	for	for	IN
cord-343791-0vykwml5	116	11	the	the	DT
cord-343791-0vykwml5	116	12	treatment	treatment	NN
cord-343791-0vykwml5	116	13	of	of	IN
cord-343791-0vykwml5	116	14	many	many	JJ
cord-343791-0vykwml5	116	15	infectious	infectious	JJ
cord-343791-0vykwml5	116	16	diseases	disease	NNS
cord-343791-0vykwml5	116	17	:	:	:
cord-343791-0vykwml5	116	18	HBV	HBV	NNP
cord-343791-0vykwml5	116	19	,	,	,
cord-343791-0vykwml5	116	20	HIV	HIV	NNP
cord-343791-0vykwml5	116	21	,	,	,
cord-343791-0vykwml5	116	22	HPV	HPV	NNP
cord-343791-0vykwml5	116	23	,	,	,
cord-343791-0vykwml5	116	24	human	human	JJ
cord-343791-0vykwml5	116	25	parvovirus	parvovirus	NN
cord-343791-0vykwml5	116	26	,	,	,
cord-343791-0vykwml5	116	27	influenza	influenza	NN
cord-343791-0vykwml5	116	28	virus	virus	NN
cord-343791-0vykwml5	116	29	A	A	NNP
cord-343791-0vykwml5	116	30	,	,	,
cord-343791-0vykwml5	116	31	norwalk	norwalk	NNP
cord-343791-0vykwml5	116	32	virus	virus	NN
cord-343791-0vykwml5	116	33	,	,	,
cord-343791-0vykwml5	116	34	ebola	ebola	NNP
cord-343791-0vykwml5	116	35	virus	virus	NN
cord-343791-0vykwml5	116	36	,	,	,
cord-343791-0vykwml5	116	37	and	and	CC
cord-343791-0vykwml5	116	38	severe	severe	JJ
cord-343791-0vykwml5	116	39	acute	acute	JJ
cord-343791-0vykwml5	116	40	respiratory	respiratory	JJ
cord-343791-0vykwml5	116	41	syndromerelated	syndromerelate	VBN
cord-343791-0vykwml5	116	42	coronavirus	coronavirus	NN
cord-343791-0vykwml5	116	43	.	.	.
cord-343791-0vykwml5	117	1	The	the	DT
cord-343791-0vykwml5	117	2	inclusion	inclusion	NN
cord-343791-0vykwml5	117	3	of	of	IN
cord-343791-0vykwml5	117	4	preclinical	preclinical	JJ
cord-343791-0vykwml5	117	5	testing	testing	NN
cord-343791-0vykwml5	117	6	to	to	IN
cord-343791-0vykwml5	117	7	this	this	DT
cord-343791-0vykwml5	117	8	list	list	NN
cord-343791-0vykwml5	117	9	broadens	broaden	VBZ
cord-343791-0vykwml5	117	10	it	-PRON-	PRP
cord-343791-0vykwml5	117	11	even	even	RB
cord-343791-0vykwml5	117	12	further	far	RBR
cord-343791-0vykwml5	117	13	,	,	,
cord-343791-0vykwml5	117	14	to	to	IN
cord-343791-0vykwml5	117	15	diseases	disease	NNS
cord-343791-0vykwml5	117	16	including	include	VBG
cord-343791-0vykwml5	117	17	chikungunya	chikungunya	NN
cord-343791-0vykwml5	117	18	virus	virus	NN
cord-343791-0vykwml5	117	19	,	,	,
cord-343791-0vykwml5	117	20	west	west	NNP
cord-343791-0vykwml5	117	21	nile	nile	NNP
cord-343791-0vykwml5	117	22	virus	virus	NN
cord-343791-0vykwml5	117	23	,	,	,
cord-343791-0vykwml5	117	24	and	and	CC
cord-343791-0vykwml5	117	25	mumps	mumps	NN
cord-343791-0vykwml5	117	26	virus	virus	NN
cord-343791-0vykwml5	117	27	.	.	.
cord-343791-0vykwml5	118	1	[	[	-LRB-
cord-343791-0vykwml5	118	2	29	29	CD
cord-343791-0vykwml5	118	3	]	]	-RRB-
cord-343791-0vykwml5	119	1	As	as	IN
cord-343791-0vykwml5	119	2	mentioned	mention	VBN
cord-343791-0vykwml5	119	3	in	in	IN
cord-343791-0vykwml5	119	4	the	the	DT
cord-343791-0vykwml5	119	5	introduction	introduction	NN
cord-343791-0vykwml5	119	6	,	,	,
cord-343791-0vykwml5	119	7	one	one	CD
cord-343791-0vykwml5	119	8	of	of	IN
cord-343791-0vykwml5	119	9	the	the	DT
cord-343791-0vykwml5	119	10	key	key	JJ
cord-343791-0vykwml5	119	11	strategic	strategic	JJ
cord-343791-0vykwml5	119	12	strengths	strength	NNS
cord-343791-0vykwml5	119	13	of	of	IN
cord-343791-0vykwml5	119	14	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	119	15	systems	system	NNS
cord-343791-0vykwml5	119	16	is	be	VBZ
cord-343791-0vykwml5	119	17	the	the	DT
cord-343791-0vykwml5	119	18	modularity	modularity	NN
cord-343791-0vykwml5	119	19	that	that	IN
cord-343791-0vykwml5	119	20	they	-PRON-	PRP
cord-343791-0vykwml5	119	21	tend	tend	VBP
cord-343791-0vykwml5	119	22	to	to	TO
cord-343791-0vykwml5	119	23	possess	possess	VB
cord-343791-0vykwml5	119	24	.	.	.
cord-343791-0vykwml5	120	1	In	in	IN
cord-343791-0vykwml5	120	2	VLPs	vlp	NNS
cord-343791-0vykwml5	120	3	,	,	,
cord-343791-0vykwml5	120	4	this	this	DT
cord-343791-0vykwml5	120	5	modularity	modularity	NN
cord-343791-0vykwml5	120	6	is	be	VBZ
cord-343791-0vykwml5	120	7	exemplified	exemplify	VBN
cord-343791-0vykwml5	120	8	by	by	IN
cord-343791-0vykwml5	120	9	chimeric	chimeric	JJ
cord-343791-0vykwml5	120	10	VLPs	vlp	NNS
cord-343791-0vykwml5	120	11	,	,	,
cord-343791-0vykwml5	120	12	in	in	IN
cord-343791-0vykwml5	120	13	which	which	WDT
cord-343791-0vykwml5	120	14	epitopes	epitope	NNS
cord-343791-0vykwml5	120	15	of	of	IN
cord-343791-0vykwml5	120	16	choice	choice	NN
cord-343791-0vykwml5	120	17	from	from	IN
cord-343791-0vykwml5	120	18	various	various	JJ
cord-343791-0vykwml5	120	19	diseases	disease	NNS
cord-343791-0vykwml5	120	20	are	be	VBP
cord-343791-0vykwml5	120	21	inserted	insert	VBN
cord-343791-0vykwml5	120	22	into	into	IN
cord-343791-0vykwml5	120	23	the	the	DT
cord-343791-0vykwml5	120	24	particle	particle	NN
cord-343791-0vykwml5	120	25	-	-	HYPH
cord-343791-0vykwml5	120	26	forming	form	VBG
cord-343791-0vykwml5	120	27	proteins	protein	NNS
cord-343791-0vykwml5	120	28	.	.	.
cord-343791-0vykwml5	121	1	Provided	provide	VBN
cord-343791-0vykwml5	121	2	that	that	IN
cord-343791-0vykwml5	121	3	the	the	DT
cord-343791-0vykwml5	121	4	new	new	JJ
cord-343791-0vykwml5	121	5	epitope	epitope	NN
cord-343791-0vykwml5	121	6	can	can	MD
cord-343791-0vykwml5	121	7	be	be	VB
cord-343791-0vykwml5	121	8	inserted	insert	VBN
cord-343791-0vykwml5	121	9	in	in	IN
cord-343791-0vykwml5	121	10	a	a	DT
cord-343791-0vykwml5	121	11	way	way	NN
cord-343791-0vykwml5	121	12	that	that	WDT
cord-343791-0vykwml5	121	13	does	do	VBZ
cord-343791-0vykwml5	121	14	not	not	RB
cord-343791-0vykwml5	121	15	disrupt	disrupt	VB
cord-343791-0vykwml5	121	16	self	self	NN
cord-343791-0vykwml5	121	17	-	-	HYPH
cord-343791-0vykwml5	121	18	assembly	assembly	NN
cord-343791-0vykwml5	121	19	,	,	,
cord-343791-0vykwml5	121	20	and	and	CC
cord-343791-0vykwml5	121	21	that	that	DT
cord-343791-0vykwml5	121	22	presents	present	VBZ
cord-343791-0vykwml5	121	23	the	the	DT
cord-343791-0vykwml5	121	24	epitope	epitope	NN
cord-343791-0vykwml5	121	25	on	on	IN
cord-343791-0vykwml5	121	26	the	the	DT
cord-343791-0vykwml5	121	27	surface	surface	NN
cord-343791-0vykwml5	121	28	of	of	IN
cord-343791-0vykwml5	121	29	the	the	DT
cord-343791-0vykwml5	121	30	particle	particle	NN
cord-343791-0vykwml5	121	31	so	so	IN
cord-343791-0vykwml5	121	32	that	that	IN
cord-343791-0vykwml5	121	33	it	-PRON-	PRP
cord-343791-0vykwml5	121	34	is	be	VBZ
cord-343791-0vykwml5	121	35	both	both	DT
cord-343791-0vykwml5	121	36	antigenic	antigenic	JJ
cord-343791-0vykwml5	121	37	and	and	CC
cord-343791-0vykwml5	121	38	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	121	39	,	,	,
cord-343791-0vykwml5	121	40	the	the	DT
cord-343791-0vykwml5	121	41	modularity	modularity	NN
cord-343791-0vykwml5	121	42	of	of	IN
cord-343791-0vykwml5	121	43	the	the	DT
cord-343791-0vykwml5	121	44	system	system	NN
cord-343791-0vykwml5	121	45	is	be	VBZ
cord-343791-0vykwml5	121	46	maintained	maintain	VBN
cord-343791-0vykwml5	121	47	.	.	.
cord-343791-0vykwml5	122	1	[	[	-LRB-
cord-343791-0vykwml5	122	2	20	20	CD
cord-343791-0vykwml5	122	3	]	]	-RRB-
cord-343791-0vykwml5	122	4	By	by	IN
cord-343791-0vykwml5	122	5	being	be	VBG
cord-343791-0vykwml5	122	6	able	able	JJ
cord-343791-0vykwml5	122	7	to	to	TO
cord-343791-0vykwml5	122	8	insert	insert	VB
cord-343791-0vykwml5	122	9	epitopes	epitope	NNS
cord-343791-0vykwml5	122	10	of	of	IN
cord-343791-0vykwml5	122	11	choice	choice	NN
cord-343791-0vykwml5	122	12	,	,	,
cord-343791-0vykwml5	122	13	the	the	DT
cord-343791-0vykwml5	122	14	range	range	NN
cord-343791-0vykwml5	122	15	of	of	IN
cord-343791-0vykwml5	122	16	therapeutic	therapeutic	JJ
cord-343791-0vykwml5	122	17	applications	application	NNS
cord-343791-0vykwml5	122	18	becomes	become	VBZ
cord-343791-0vykwml5	122	19	quite	quite	RB
cord-343791-0vykwml5	122	20	broad	broad	JJ
cord-343791-0vykwml5	122	21	.	.	.
cord-343791-0vykwml5	123	1	For	for	IN
cord-343791-0vykwml5	123	2	example	example	NN
cord-343791-0vykwml5	123	3	,	,	,
cord-343791-0vykwml5	123	4	several	several	JJ
cord-343791-0vykwml5	123	5	clinical	clinical	JJ
cord-343791-0vykwml5	123	6	studies	study	NNS
cord-343791-0vykwml5	123	7	are	be	VBP
cord-343791-0vykwml5	123	8	currently	currently	RB
cord-343791-0vykwml5	123	9	evaluating	evaluate	VBG
cord-343791-0vykwml5	123	10	chimeric	chimeric	JJ
cord-343791-0vykwml5	123	11	VLP	VLP	NNP
cord-343791-0vykwml5	123	12	vaccines	vaccine	NNS
cord-343791-0vykwml5	123	13	for	for	IN
cord-343791-0vykwml5	123	14	the	the	DT
cord-343791-0vykwml5	123	15	treatment	treatment	NN
cord-343791-0vykwml5	123	16	of	of	IN
cord-343791-0vykwml5	123	17	noninfectious	noninfectious	JJ
cord-343791-0vykwml5	123	18	diseases	disease	NNS
cord-343791-0vykwml5	123	19	such	such	JJ
cord-343791-0vykwml5	123	20	as	as	IN
cord-343791-0vykwml5	123	21	cancer	cancer	NN
cord-343791-0vykwml5	123	22	(	(	-LRB-
cord-343791-0vykwml5	123	23	melanoma	melanoma	NN
cord-343791-0vykwml5	123	24	)	)	-RRB-
cord-343791-0vykwml5	123	25	,	,	,
cord-343791-0vykwml5	123	26	[	[	-LRB-
cord-343791-0vykwml5	123	27	30	30	CD
cord-343791-0vykwml5	123	28	]	]	-RRB-
cord-343791-0vykwml5	123	29	neurodegenerative	neurodegenerative	JJ
cord-343791-0vykwml5	123	30	diseases	disease	NNS
cord-343791-0vykwml5	123	31	(	(	-LRB-
cord-343791-0vykwml5	123	32	Alzheimer	Alzheimer	NNP
cord-343791-0vykwml5	123	33	's	's	POS
cord-343791-0vykwml5	123	34	disease	disease	NN
cord-343791-0vykwml5	123	35	)	)	-RRB-
cord-343791-0vykwml5	123	36	,	,	,
cord-343791-0vykwml5	123	37	[	[	-LRB-
cord-343791-0vykwml5	123	38	31	31	CD
cord-343791-0vykwml5	123	39	]	]	-RRB-
cord-343791-0vykwml5	123	40	autoimmune	autoimmune	JJ
cord-343791-0vykwml5	123	41	diseases	disease	NNS
cord-343791-0vykwml5	123	42	(	(	-LRB-
cord-343791-0vykwml5	123	43	allergic	allergic	JJ
cord-343791-0vykwml5	123	44	rhinoconjunctivitis	rhinoconjunctivitis	NN
cord-343791-0vykwml5	123	45	and	and	CC
cord-343791-0vykwml5	123	46	asthmas	asthmas	NNP
cord-343791-0vykwml5	123	47	)	)	-RRB-
cord-343791-0vykwml5	123	48	,	,	,
cord-343791-0vykwml5	123	49	[	[	-LRB-
cord-343791-0vykwml5	123	50	32	32	CD
cord-343791-0vykwml5	123	51	]	]	-RRB-
cord-343791-0vykwml5	123	52	and	and	CC
cord-343791-0vykwml5	123	53	other	other	JJ
cord-343791-0vykwml5	123	54	disorders	disorder	NNS
cord-343791-0vykwml5	123	55	.	.	.
cord-343791-0vykwml5	124	1	Another	another	DT
cord-343791-0vykwml5	124	2	approach	approach	NN
cord-343791-0vykwml5	124	3	for	for	IN
cord-343791-0vykwml5	124	4	including	include	VBG
cord-343791-0vykwml5	124	5	chosen	choose	VBN
cord-343791-0vykwml5	124	6	epitopes/	epitopes/	CD
cord-343791-0vykwml5	124	7	antigens	antigen	NNS
cord-343791-0vykwml5	124	8	is	be	VBZ
cord-343791-0vykwml5	124	9	separately	separately	RB
cord-343791-0vykwml5	124	10	expressing	express	VBG
cord-343791-0vykwml5	124	11	the	the	DT
cord-343791-0vykwml5	124	12	VLP	VLP	NNP
cord-343791-0vykwml5	124	13	and	and	CC
cord-343791-0vykwml5	124	14	target	target	VB
cord-343791-0vykwml5	124	15	protein	protein	NN
cord-343791-0vykwml5	124	16	and	and	CC
cord-343791-0vykwml5	124	17	conjugating	conjugate	VBG
cord-343791-0vykwml5	124	18	them	-PRON-	PRP
cord-343791-0vykwml5	124	19	together	together	RB
cord-343791-0vykwml5	124	20	.	.	.
cord-343791-0vykwml5	125	1	This	this	DT
cord-343791-0vykwml5	125	2	approach	approach	NN
cord-343791-0vykwml5	125	3	is	be	VBZ
cord-343791-0vykwml5	125	4	often	often	RB
cord-343791-0vykwml5	125	5	preferable	preferable	JJ
cord-343791-0vykwml5	125	6	and	and	CC
cord-343791-0vykwml5	125	7	necessary	necessary	JJ
cord-343791-0vykwml5	125	8	due	due	IN
cord-343791-0vykwml5	125	9	to	to	IN
cord-343791-0vykwml5	125	10	differences	difference	NNS
cord-343791-0vykwml5	125	11	in	in	IN
cord-343791-0vykwml5	125	12	optimal	optimal	JJ
cord-343791-0vykwml5	125	13	expression	expression	NN
cord-343791-0vykwml5	125	14	conditions	condition	NNS
cord-343791-0vykwml5	125	15	for	for	IN
cord-343791-0vykwml5	125	16	each	each	DT
cord-343791-0vykwml5	125	17	component	component	NN
cord-343791-0vykwml5	125	18	.	.	.
cord-343791-0vykwml5	126	1	Thus	thus	RB
cord-343791-0vykwml5	126	2	,	,	,
cord-343791-0vykwml5	126	3	postproduction	postproduction	NN
cord-343791-0vykwml5	126	4	methods	method	NNS
cord-343791-0vykwml5	126	5	have	have	VBP
cord-343791-0vykwml5	126	6	been	be	VBN
cord-343791-0vykwml5	126	7	developed	develop	VBN
cord-343791-0vykwml5	126	8	to	to	TO
cord-343791-0vykwml5	126	9	link	link	VB
cord-343791-0vykwml5	126	10	the	the	DT
cord-343791-0vykwml5	126	11	VLP	VLP	NNP
cord-343791-0vykwml5	126	12	and	and	CC
cord-343791-0vykwml5	126	13	target	target	NN
cord-343791-0vykwml5	126	14	antigen	antigen	NN
cord-343791-0vykwml5	126	15	.	.	.
cord-343791-0vykwml5	127	1	This	this	DT
cord-343791-0vykwml5	127	2	is	be	VBZ
cord-343791-0vykwml5	127	3	achieved	achieve	VBN
cord-343791-0vykwml5	127	4	through	through	IN
cord-343791-0vykwml5	127	5	genetic	genetic	JJ
cord-343791-0vykwml5	127	6	manipulation	manipulation	NN
cord-343791-0vykwml5	127	7	,	,	,
cord-343791-0vykwml5	127	8	coupling	couple	VBG
cord-343791-0vykwml5	127	9	via	via	IN
cord-343791-0vykwml5	127	10	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	127	11	or	or	CC
cord-343791-0vykwml5	127	12	covalent	covalent	JJ
cord-343791-0vykwml5	127	13	bonds	bond	NNS
cord-343791-0vykwml5	127	14	,	,	,
cord-343791-0vykwml5	127	15	or	or	CC
cord-343791-0vykwml5	127	16	by	by	IN
cord-343791-0vykwml5	127	17	encapsulation	encapsulation	NN
cord-343791-0vykwml5	127	18	of	of	IN
cord-343791-0vykwml5	127	19	cargo	cargo	NN
cord-343791-0vykwml5	127	20	by	by	IN
cord-343791-0vykwml5	127	21	disassembling	disassemble	VBG
cord-343791-0vykwml5	127	22	and	and	CC
cord-343791-0vykwml5	127	23	reassembling	reassemble	VBG
cord-343791-0vykwml5	127	24	purified	purify	VBN
cord-343791-0vykwml5	127	25	VLPs	vlp	NNS
cord-343791-0vykwml5	127	26	in	in	IN
cord-343791-0vykwml5	127	27	the	the	DT
cord-343791-0vykwml5	127	28	presence	presence	NN
cord-343791-0vykwml5	127	29	of	of	IN
cord-343791-0vykwml5	127	30	the	the	DT
cord-343791-0vykwml5	127	31	desired	desire	VBN
cord-343791-0vykwml5	127	32	molecule	molecule	NN
cord-343791-0vykwml5	127	33	.	.	.
cord-343791-0vykwml5	128	1	[	[	-LRB-
cord-343791-0vykwml5	128	2	33	33	CD
cord-343791-0vykwml5	128	3	]	]	-RRB-
cord-343791-0vykwml5	129	1	Coupling	coupling	NN
cord-343791-0vykwml5	129	2	chemistries	chemistry	NNS
cord-343791-0vykwml5	129	3	range	range	VBP
cord-343791-0vykwml5	129	4	from	from	IN
cord-343791-0vykwml5	129	5	the	the	DT
cord-343791-0vykwml5	129	6	use	use	NN
cord-343791-0vykwml5	129	7	of	of	IN
cord-343791-0vykwml5	129	8	bifunctional	bifunctional	JJ
cord-343791-0vykwml5	129	9	crosslinkers	crosslinker	NNS
cord-343791-0vykwml5	129	10	,	,	,
cord-343791-0vykwml5	129	11	click	click	VB
cord-343791-0vykwml5	129	12	chemistry	chemistry	NN
cord-343791-0vykwml5	129	13	,	,	,
cord-343791-0vykwml5	129	14	sortase	sortase	NN
cord-343791-0vykwml5	129	15	-	-	HYPH
cord-343791-0vykwml5	129	16	mediated	mediate	VBN
cord-343791-0vykwml5	129	17	attachment	attachment	NN
cord-343791-0vykwml5	129	18	,	,	,
cord-343791-0vykwml5	129	19	polyhistidine	polyhistidine	NNP
cord-343791-0vykwml5	129	20	/	/	SYM
cord-343791-0vykwml5	129	21	NTA	NTA	NNP
cord-343791-0vykwml5	129	22	-	-	HYPH
cord-343791-0vykwml5	129	23	Ni	Ni	NNP
cord-343791-0vykwml5	129	24	2	2	CD
cord-343791-0vykwml5	129	25	+	+	SYM
cord-343791-0vykwml5	129	26	,	,	,
cord-343791-0vykwml5	129	27	or	or	CC
cord-343791-0vykwml5	129	28	affinity	affinity	NN
cord-343791-0vykwml5	129	29	-	-	HYPH
cord-343791-0vykwml5	129	30	tag	tag	NN
cord-343791-0vykwml5	129	31	interactions	interaction	NNS
cord-343791-0vykwml5	129	32	to	to	TO
cord-343791-0vykwml5	129	33	conjugate	conjugate	VB
cord-343791-0vykwml5	129	34	the	the	DT
cord-343791-0vykwml5	129	35	VLP	VLP	NNP
cord-343791-0vykwml5	129	36	and	and	CC
cord-343791-0vykwml5	129	37	target	target	VB
cord-343791-0vykwml5	129	38	antigen	antigen	NN
cord-343791-0vykwml5	129	39	[	[	-LRB-
cord-343791-0vykwml5	129	40	34	34	CD
cord-343791-0vykwml5	129	41	]	]	-RRB-
cord-343791-0vykwml5	130	1	Notably	notably	RB
cord-343791-0vykwml5	130	2	,	,	,
cord-343791-0vykwml5	130	3	these	these	DT
cord-343791-0vykwml5	130	4	postproduction	postproduction	NN
cord-343791-0vykwml5	130	5	-	-	HYPH
cord-343791-0vykwml5	130	6	modified	modify	VBN
cord-343791-0vykwml5	130	7	VLPs	vlp	NNS
cord-343791-0vykwml5	130	8	have	have	VBP
cord-343791-0vykwml5	130	9	led	lead	VBN
cord-343791-0vykwml5	130	10	to	to	IN
cord-343791-0vykwml5	130	11	several	several	JJ
cord-343791-0vykwml5	130	12	platforms	platform	NNS
cord-343791-0vykwml5	130	13	currently	currently	RB
cord-343791-0vykwml5	130	14	being	be	VBG
cord-343791-0vykwml5	130	15	tested	test	VBN
cord-343791-0vykwml5	130	16	in	in	IN
cord-343791-0vykwml5	130	17	clinical	clinical	JJ
cord-343791-0vykwml5	130	18	trials	trial	NNS
cord-343791-0vykwml5	130	19	.	.	.
cord-343791-0vykwml5	131	1	[	[	-LRB-
cord-343791-0vykwml5	131	2	35	35	CD
cord-343791-0vykwml5	131	3	]	]	-RRB-
cord-343791-0vykwml5	131	4	[	[	-LRB-
cord-343791-0vykwml5	131	5	36	36	CD
cord-343791-0vykwml5	131	6	]	]	-RRB-
cord-343791-0vykwml5	132	1	[	[	-LRB-
cord-343791-0vykwml5	132	2	37	37	CD
cord-343791-0vykwml5	132	3	]	]	-RRB-
cord-343791-0vykwml5	133	1	Although	although	IN
cord-343791-0vykwml5	133	2	a	a	DT
cord-343791-0vykwml5	133	3	range	range	NN
cord-343791-0vykwml5	133	4	of	of	IN
cord-343791-0vykwml5	133	5	chemical	chemical	JJ
cord-343791-0vykwml5	133	6	cross	cross	NN
cord-343791-0vykwml5	133	7	-	-	JJ
cord-343791-0vykwml5	133	8	linking	linking	JJ
cord-343791-0vykwml5	133	9	strategies	strategy	NNS
cord-343791-0vykwml5	133	10	have	have	VBP
cord-343791-0vykwml5	133	11	been	be	VBN
cord-343791-0vykwml5	133	12	developed	develop	VBN
cord-343791-0vykwml5	133	13	for	for	IN
cord-343791-0vykwml5	133	14	VLPs	vlp	NNS
cord-343791-0vykwml5	133	15	,	,	,
cord-343791-0vykwml5	133	16	[	[	-LRB-
cord-343791-0vykwml5	133	17	38	38	CD
cord-343791-0vykwml5	133	18	,	,	,
cord-343791-0vykwml5	133	19	39	39	CD
cord-343791-0vykwml5	133	20	]	]	-RRB-
cord-343791-0vykwml5	133	21	conjugation	conjugation	NN
cord-343791-0vykwml5	133	22	of	of	IN
cord-343791-0vykwml5	133	23	target	target	NN
cord-343791-0vykwml5	133	24	antigens	antigen	NNS
cord-343791-0vykwml5	133	25	with	with	IN
cord-343791-0vykwml5	133	26	multiple	multiple	JJ
cord-343791-0vykwml5	133	27	reactive	reactive	JJ
cord-343791-0vykwml5	133	28	sites	site	NNS
cord-343791-0vykwml5	133	29	can	can	MD
cord-343791-0vykwml5	133	30	lead	lead	VB
cord-343791-0vykwml5	133	31	to	to	IN
cord-343791-0vykwml5	133	32	heterogeneous	heterogeneous	JJ
cord-343791-0vykwml5	133	33	coupling	coupling	NN
cord-343791-0vykwml5	133	34	or	or	CC
cord-343791-0vykwml5	133	35	unfavorable	unfavorable	JJ
cord-343791-0vykwml5	133	36	epitope	epitope	NN
cord-343791-0vykwml5	133	37	display	display	NN
cord-343791-0vykwml5	133	38	.	.	.
cord-343791-0vykwml5	134	1	[	[	-LRB-
cord-343791-0vykwml5	134	2	38	38	CD
cord-343791-0vykwml5	134	3	]	]	-RRB-
cord-343791-0vykwml5	135	1	The	the	DT
cord-343791-0vykwml5	135	2	Bachmann	Bachmann	NNP
cord-343791-0vykwml5	135	3	group	group	NN
cord-343791-0vykwml5	135	4	addressed	address	VBD
cord-343791-0vykwml5	135	5	this	this	DT
cord-343791-0vykwml5	135	6	challenge	challenge	NN
cord-343791-0vykwml5	135	7	using	use	VBG
cord-343791-0vykwml5	135	8	the	the	DT
cord-343791-0vykwml5	135	9	SpyTag	SpyTag	NNP
cord-343791-0vykwml5	135	10	-	-	HYPH
cord-343791-0vykwml5	135	11	SpyCatcher	SpyCatcher	NNP
cord-343791-0vykwml5	135	12	system	system	NN
cord-343791-0vykwml5	135	13	.	.	.
cord-343791-0vykwml5	136	1	[	[	-LRB-
cord-343791-0vykwml5	136	2	40	40	CD
cord-343791-0vykwml5	136	3	]	]	-RRB-
cord-343791-0vykwml5	136	4	SpyTag	SpyTag	NNP
cord-343791-0vykwml5	136	5	is	be	VBZ
cord-343791-0vykwml5	136	6	a	a	DT
cord-343791-0vykwml5	136	7	peptide	peptide	NN
cord-343791-0vykwml5	136	8	that	that	WDT
cord-343791-0vykwml5	136	9	forms	form	VBZ
cord-343791-0vykwml5	136	10	a	a	DT
cord-343791-0vykwml5	136	11	spontaneous	spontaneous	JJ
cord-343791-0vykwml5	136	12	and	and	CC
cord-343791-0vykwml5	136	13	irreversible	irreversible	JJ
cord-343791-0vykwml5	136	14	isopeptide	isopeptide	NN
cord-343791-0vykwml5	136	15	bond	bond	NN
cord-343791-0vykwml5	136	16	with	with	IN
cord-343791-0vykwml5	136	17	SpyCatcher	SpyCatcher	NNP
cord-343791-0vykwml5	136	18	,	,	,
cord-343791-0vykwml5	136	19	its	-PRON-	PRP$
cord-343791-0vykwml5	136	20	protein	protein	NN
cord-343791-0vykwml5	136	21	partner	partner	NN
cord-343791-0vykwml5	136	22	.	.	.
cord-343791-0vykwml5	137	1	[	[	-LRB-
cord-343791-0vykwml5	137	2	40	40	CD
cord-343791-0vykwml5	137	3	]	]	-RRB-
cord-343791-0vykwml5	138	1	The	the	DT
cord-343791-0vykwml5	138	2	SpyCatcher	SpyCatcher	NNP
cord-343791-0vykwml5	138	3	-	-	HYPH
cord-343791-0vykwml5	138	4	VLP	VLP	NNP
cord-343791-0vykwml5	138	5	platform	platform	NN
cord-343791-0vykwml5	138	6	is	be	VBZ
cord-343791-0vykwml5	138	7	expressed	express	VBN
cord-343791-0vykwml5	138	8	in	in	IN
cord-343791-0vykwml5	138	9	Escherichia	Escherichia	NNP
cord-343791-0vykwml5	138	10	coli	coli	NNS
cord-343791-0vykwml5	138	11	and	and	CC
cord-343791-0vykwml5	138	12	mixed	mix	VBN
cord-343791-0vykwml5	138	13	with	with	IN
cord-343791-0vykwml5	138	14	SpyTag	SpyTag	NNP
cord-343791-0vykwml5	138	15	-	-	HYPH
cord-343791-0vykwml5	138	16	Antigen	Antigen	NNP
cord-343791-0vykwml5	138	17	to	to	TO
cord-343791-0vykwml5	138	18	form	form	VB
cord-343791-0vykwml5	138	19	"	"	``
cord-343791-0vykwml5	138	20	Plugand	Plugand	NNP
cord-343791-0vykwml5	138	21	-	-	HYPH
cord-343791-0vykwml5	138	22	Display	display	NN
cord-343791-0vykwml5	138	23	"	"	''
cord-343791-0vykwml5	138	24	decorated	decorate	VBN
cord-343791-0vykwml5	138	25	VLPs	vlp	NNS
cord-343791-0vykwml5	138	26	,	,	,
cord-343791-0vykwml5	138	27	another	another	DT
cord-343791-0vykwml5	138	28	highly	highly	RB
cord-343791-0vykwml5	138	29	modular	modular	JJ
cord-343791-0vykwml5	138	30	,	,	,
cord-343791-0vykwml5	138	31	tunable	tunable	JJ
cord-343791-0vykwml5	138	32	approach	approach	NN
cord-343791-0vykwml5	138	33	that	that	WDT
cord-343791-0vykwml5	138	34	allows	allow	VBZ
cord-343791-0vykwml5	138	35	for	for	IN
cord-343791-0vykwml5	138	36	incorporation	incorporation	NN
cord-343791-0vykwml5	138	37	of	of	IN
cord-343791-0vykwml5	138	38	a	a	DT
cord-343791-0vykwml5	138	39	wide	wide	JJ
cord-343791-0vykwml5	138	40	variety	variety	NN
cord-343791-0vykwml5	138	41	of	of	IN
cord-343791-0vykwml5	138	42	antigens	antigen	NNS
cord-343791-0vykwml5	138	43	to	to	IN
cord-343791-0vykwml5	138	44	the	the	DT
cord-343791-0vykwml5	138	45	VLP	VLP	NNP
cord-343791-0vykwml5	138	46	surface	surface	NN
cord-343791-0vykwml5	138	47	.	.	.
cord-343791-0vykwml5	139	1	The	the	DT
cord-343791-0vykwml5	139	2	group	group	NN
cord-343791-0vykwml5	139	3	reported	report	VBD
cord-343791-0vykwml5	139	4	that	that	IN
cord-343791-0vykwml5	139	5	SpyCatcher	SpyCatcher	NNP
cord-343791-0vykwml5	139	6	-	-	HYPH
cord-343791-0vykwml5	139	7	VLPs	vlp	NNS
cord-343791-0vykwml5	139	8	decorated	decorate	VBN
cord-343791-0vykwml5	139	9	with	with	IN
cord-343791-0vykwml5	139	10	the	the	DT
cord-343791-0vykwml5	139	11	CIDR	CIDR	NNP
cord-343791-0vykwml5	139	12	or	or	CC
cord-343791-0vykwml5	139	13	Pfs25	Pfs25	NNP
cord-343791-0vykwml5	139	14	antigens	antigen	NNS
cord-343791-0vykwml5	139	15	generated	generate	VBD
cord-343791-0vykwml5	139	16	a	a	DT
cord-343791-0vykwml5	139	17	robust	robust	JJ
cord-343791-0vykwml5	139	18	antibody	antibody	NN
cord-343791-0vykwml5	139	19	response	response	NN
cord-343791-0vykwml5	139	20	are	be	VBP
cord-343791-0vykwml5	139	21	only	only	RB
cord-343791-0vykwml5	139	22	a	a	DT
cord-343791-0vykwml5	139	23	single	single	JJ
cord-343791-0vykwml5	139	24	immunization	immunization	NN
cord-343791-0vykwml5	139	25	without	without	IN
cord-343791-0vykwml5	139	26	requiring	require	VBG
cord-343791-0vykwml5	139	27	adjuvant	adjuvant	NN
cord-343791-0vykwml5	139	28	.	.	.
cord-343791-0vykwml5	140	1	This	this	DT
cord-343791-0vykwml5	140	2	platform	platform	NN
cord-343791-0vykwml5	140	3	shows	show	VBZ
cord-343791-0vykwml5	140	4	promise	promise	NN
cord-343791-0vykwml5	140	5	in	in	IN
cord-343791-0vykwml5	140	6	application	application	NN
cord-343791-0vykwml5	140	7	such	such	JJ
cord-343791-0vykwml5	140	8	as	as	IN
cord-343791-0vykwml5	140	9	drug	drug	NN
cord-343791-0vykwml5	140	10	delivery	delivery	NN
cord-343791-0vykwml5	140	11	,	,	,
cord-343791-0vykwml5	140	12	enzyme	enzyme	NN
cord-343791-0vykwml5	140	13	scaffolds	scaffold	NNS
cord-343791-0vykwml5	140	14	,	,	,
cord-343791-0vykwml5	140	15	biosensors	biosensor	NNS
cord-343791-0vykwml5	140	16	,	,	,
cord-343791-0vykwml5	140	17	and	and	CC
cord-343791-0vykwml5	140	18	cancer	cancer	NN
cord-343791-0vykwml5	140	19	immunotherapy	immunotherapy	NN
cord-343791-0vykwml5	140	20	,	,	,
cord-343791-0vykwml5	140	21	[	[	-LRB-
cord-343791-0vykwml5	140	22	41	41	CD
cord-343791-0vykwml5	140	23	]	]	-RRB-
cord-343791-0vykwml5	140	24	and	and	CC
cord-343791-0vykwml5	140	25	it	-PRON-	PRP
cord-343791-0vykwml5	140	26	mitigates	mitigate	VBZ
cord-343791-0vykwml5	140	27	the	the	DT
cord-343791-0vykwml5	140	28	need	need	NN
cord-343791-0vykwml5	140	29	for	for	IN
cord-343791-0vykwml5	140	30	complex	complex	JJ
cord-343791-0vykwml5	140	31	chimeric	chimeric	JJ
cord-343791-0vykwml5	140	32	protein	protein	NN
cord-343791-0vykwml5	140	33	expression	expression	NN
cord-343791-0vykwml5	140	34	or	or	CC
cord-343791-0vykwml5	140	35	the	the	DT
cord-343791-0vykwml5	140	36	incorporation	incorporation	NN
cord-343791-0vykwml5	140	37	of	of	IN
cord-343791-0vykwml5	140	38	unnatural	unnatural	JJ
cord-343791-0vykwml5	140	39	amino	amino	JJ
cord-343791-0vykwml5	140	40	acids	acid	NNS
cord-343791-0vykwml5	140	41	,	,	,
cord-343791-0vykwml5	140	42	as	as	IN
cord-343791-0vykwml5	140	43	would	would	MD
cord-343791-0vykwml5	140	44	be	be	VB
cord-343791-0vykwml5	140	45	necessary	necessary	JJ
cord-343791-0vykwml5	140	46	in	in	IN
cord-343791-0vykwml5	140	47	coppercatalyzed	coppercatalyze	VBN
cord-343791-0vykwml5	140	48	azide	azide	NN
cord-343791-0vykwml5	140	49	-	-	HYPH
cord-343791-0vykwml5	140	50	alkyne	alkyne	NN
cord-343791-0vykwml5	140	51	cycloaddition	cycloaddition	NN
cord-343791-0vykwml5	140	52	(	(	-LRB-
cord-343791-0vykwml5	140	53	click	click	VB
cord-343791-0vykwml5	140	54	chemistry	chemistry	NN
cord-343791-0vykwml5	140	55	)	)	-RRB-
cord-343791-0vykwml5	140	56	or	or	CC
cord-343791-0vykwml5	140	57	other	other	JJ
cord-343791-0vykwml5	140	58	chemoselective	chemoselective	JJ
cord-343791-0vykwml5	140	59	bioconjugation	bioconjugation	NN
cord-343791-0vykwml5	140	60	reactions	reaction	NNS
cord-343791-0vykwml5	140	61	.	.	.
cord-343791-0vykwml5	141	1	VLPs	vlp	NNS
cord-343791-0vykwml5	141	2	,	,	,
cord-343791-0vykwml5	141	3	owing	owe	VBG
cord-343791-0vykwml5	141	4	to	to	IN
cord-343791-0vykwml5	141	5	their	-PRON-	PRP$
cord-343791-0vykwml5	141	6	structural	structural	JJ
cord-343791-0vykwml5	141	7	definition	definition	NN
cord-343791-0vykwml5	141	8	and	and	CC
cord-343791-0vykwml5	141	9	flexibility	flexibility	NN
cord-343791-0vykwml5	141	10	in	in	IN
cord-343791-0vykwml5	141	11	formulation	formulation	NN
cord-343791-0vykwml5	141	12	,	,	,
cord-343791-0vykwml5	141	13	also	also	RB
cord-343791-0vykwml5	141	14	make	make	VB
cord-343791-0vykwml5	141	15	useful	useful	JJ
cord-343791-0vykwml5	141	16	experimental	experimental	JJ
cord-343791-0vykwml5	141	17	tools	tool	NNS
cord-343791-0vykwml5	141	18	for	for	IN
cord-343791-0vykwml5	141	19	studying	study	VBG
cord-343791-0vykwml5	141	20	basic	basic	JJ
cord-343791-0vykwml5	141	21	aspects	aspect	NNS
cord-343791-0vykwml5	141	22	of	of	IN
cord-343791-0vykwml5	141	23	immunity	immunity	NN
cord-343791-0vykwml5	141	24	.	.	.
cord-343791-0vykwml5	142	1	They	-PRON-	PRP
cord-343791-0vykwml5	142	2	usually	usually	RB
cord-343791-0vykwml5	142	3	range	range	VBP
cord-343791-0vykwml5	142	4	in	in	IN
cord-343791-0vykwml5	142	5	diameter	diameter	NN
cord-343791-0vykwml5	142	6	from	from	IN
cord-343791-0vykwml5	142	7	20	20	CD
cord-343791-0vykwml5	142	8	-	-	SYM
cord-343791-0vykwml5	142	9	200	200	CD
cord-343791-0vykwml5	142	10	nm	nm	NN
cord-343791-0vykwml5	142	11	,	,	,
cord-343791-0vykwml5	142	12	an	an	DT
cord-343791-0vykwml5	142	13	optimal	optimal	JJ
cord-343791-0vykwml5	142	14	size	size	NN
cord-343791-0vykwml5	142	15	for	for	IN
cord-343791-0vykwml5	142	16	drainage	drainage	NN
cord-343791-0vykwml5	142	17	to	to	IN
cord-343791-0vykwml5	142	18	lymph	lymph	NN
cord-343791-0vykwml5	142	19	nodes	node	NNS
cord-343791-0vykwml5	142	20	and	and	CC
cord-343791-0vykwml5	142	21	subsequent	subsequent	JJ
cord-343791-0vykwml5	142	22	interactions	interaction	NNS
cord-343791-0vykwml5	142	23	with	with	IN
cord-343791-0vykwml5	142	24	B	b	NN
cord-343791-0vykwml5	142	25	cells	cell	NNS
cord-343791-0vykwml5	142	26	.	.	.
cord-343791-0vykwml5	143	1	Whereas	whereas	IN
cord-343791-0vykwml5	143	2	the	the	DT
cord-343791-0vykwml5	143	3	differentiation	differentiation	NN
cord-343791-0vykwml5	143	4	of	of	IN
cord-343791-0vykwml5	143	5	naïve	naïve	JJ
cord-343791-0vykwml5	143	6	B	b	NN
cord-343791-0vykwml5	143	7	cells	cell	NNS
cord-343791-0vykwml5	143	8	into	into	IN
cord-343791-0vykwml5	143	9	memory	memory	NN
cord-343791-0vykwml5	143	10	B	b	NN
cord-343791-0vykwml5	143	11	cells	cell	NNS
cord-343791-0vykwml5	143	12	has	have	VBZ
cord-343791-0vykwml5	143	13	been	be	VBN
cord-343791-0vykwml5	143	14	extensively	extensively	RB
cord-343791-0vykwml5	143	15	studied	study	VBN
cord-343791-0vykwml5	143	16	at	at	IN
cord-343791-0vykwml5	143	17	the	the	DT
cord-343791-0vykwml5	143	18	cellular	cellular	JJ
cord-343791-0vykwml5	143	19	and	and	CC
cord-343791-0vykwml5	143	20	molecular	molecular	JJ
cord-343791-0vykwml5	143	21	level	level	NN
cord-343791-0vykwml5	143	22	,	,	,
cord-343791-0vykwml5	143	23	the	the	DT
cord-343791-0vykwml5	143	24	fate	fate	NN
cord-343791-0vykwml5	143	25	of	of	IN
cord-343791-0vykwml5	143	26	memory	memory	NN
cord-343791-0vykwml5	143	27	B	b	NN
cord-343791-0vykwml5	143	28	cells	cell	NNS
cord-343791-0vykwml5	143	29	upon	upon	IN
cord-343791-0vykwml5	143	30	antigen	antigen	NN
cord-343791-0vykwml5	143	31	re	re	NN
cord-343791-0vykwml5	143	32	-	-	NN
cord-343791-0vykwml5	143	33	encounter	encounter	NN
cord-343791-0vykwml5	143	34	has	have	VBZ
cord-343791-0vykwml5	143	35	been	be	VBN
cord-343791-0vykwml5	143	36	comparatively	comparatively	RB
cord-343791-0vykwml5	143	37	less	less	RBR
cord-343791-0vykwml5	143	38	well	well	RB
cord-343791-0vykwml5	143	39	-	-	HYPH
cord-343791-0vykwml5	143	40	studied	study	VBN
cord-343791-0vykwml5	143	41	.	.	.
cord-343791-0vykwml5	144	1	The	the	DT
cord-343791-0vykwml5	144	2	Bachmann	Bachmann	NNP
cord-343791-0vykwml5	144	3	group	group	NN
cord-343791-0vykwml5	144	4	used	use	VBD
cord-343791-0vykwml5	144	5	a	a	DT
cord-343791-0vykwml5	144	6	Qβ	Qβ	NNP
cord-343791-0vykwml5	144	7	VLP	VLP	NNP
cord-343791-0vykwml5	144	8	as	as	IN
cord-343791-0vykwml5	144	9	a	a	DT
cord-343791-0vykwml5	144	10	model	model	NN
cord-343791-0vykwml5	144	11	system	system	NN
cord-343791-0vykwml5	144	12	and	and	CC
cord-343791-0vykwml5	144	13	were	be	VBD
cord-343791-0vykwml5	144	14	able	able	JJ
cord-343791-0vykwml5	144	15	to	to	TO
cord-343791-0vykwml5	144	16	track	track	VB
cord-343791-0vykwml5	144	17	VLP	VLP	NNP
cord-343791-0vykwml5	144	18	-	-	HYPH
cord-343791-0vykwml5	144	19	specific	specific	JJ
cord-343791-0vykwml5	144	20	B	b	NN
cord-343791-0vykwml5	144	21	cells	cell	NNS
cord-343791-0vykwml5	144	22	via	via	IN
cord-343791-0vykwml5	144	23	flow	flow	NN
cord-343791-0vykwml5	144	24	cytometry	cytometry	NN
cord-343791-0vykwml5	144	25	and	and	CC
cord-343791-0vykwml5	144	26	histology	histology	NN
cord-343791-0vykwml5	144	27	to	to	TO
cord-343791-0vykwml5	144	28	follow	follow	VB
cord-343791-0vykwml5	144	29	naïve	naïve	JJ
cord-343791-0vykwml5	144	30	and	and	CC
cord-343791-0vykwml5	144	31	memory	memory	NN
cord-343791-0vykwml5	144	32	B	b	NN
cord-343791-0vykwml5	144	33	cell	cell	NN
cord-343791-0vykwml5	144	34	responses	response	NNS
cord-343791-0vykwml5	144	35	.	.	.
cord-343791-0vykwml5	145	1	[	[	-LRB-
cord-343791-0vykwml5	145	2	42	42	CD
cord-343791-0vykwml5	145	3	]	]	-RRB-
cord-343791-0vykwml5	146	1	They	-PRON-	PRP
cord-343791-0vykwml5	146	2	unexpectedly	unexpectedly	RB
cord-343791-0vykwml5	146	3	found	find	VBD
cord-343791-0vykwml5	146	4	that	that	IN
cord-343791-0vykwml5	146	5	,	,	,
cord-343791-0vykwml5	146	6	during	during	IN
cord-343791-0vykwml5	146	7	secondary	secondary	JJ
cord-343791-0vykwml5	146	8	B	b	NN
cord-343791-0vykwml5	146	9	cell	cell	NN
cord-343791-0vykwml5	146	10	responses	response	NNS
cord-343791-0vykwml5	146	11	,	,	,
cord-343791-0vykwml5	146	12	secondary	secondary	JJ
cord-343791-0vykwml5	146	13	plasma	plasma	NN
cord-343791-0vykwml5	146	14	cells	cell	NNS
cord-343791-0vykwml5	146	15	are	be	VBP
cord-343791-0vykwml5	146	16	generated	generate	VBN
cord-343791-0vykwml5	146	17	,	,	,
cord-343791-0vykwml5	146	18	whereas	whereas	IN
cord-343791-0vykwml5	146	19	naïve	naïve	JJ
cord-343791-0vykwml5	146	20	B	B	NNP
cord-343791-0vykwml5	146	21	cells	cell	NNS
cord-343791-0vykwml5	146	22	are	be	VBP
cord-343791-0vykwml5	146	23	recruited	recruit	VBN
cord-343791-0vykwml5	146	24	into	into	IN
cord-343791-0vykwml5	146	25	a	a	DT
cord-343791-0vykwml5	146	26	parallel	parallel	JJ
cord-343791-0vykwml5	146	27	primary	primary	NN
cord-343791-0vykwml5	146	28	B	b	NN
cord-343791-0vykwml5	146	29	cell	cell	NN
cord-343791-0vykwml5	146	30	response	response	NN
cord-343791-0vykwml5	146	31	.	.	.
cord-343791-0vykwml5	147	1	This	this	DT
cord-343791-0vykwml5	147	2	phenomenon	phenomenon	NN
cord-343791-0vykwml5	147	3	allows	allow	VBZ
cord-343791-0vykwml5	147	4	a	a	DT
cord-343791-0vykwml5	147	5	plasticity	plasticity	NN
cord-343791-0vykwml5	147	6	of	of	IN
cord-343791-0vykwml5	147	7	the	the	DT
cord-343791-0vykwml5	147	8	memory	memory	NN
cord-343791-0vykwml5	147	9	B	B	NNP
cord-343791-0vykwml5	147	10	cell	cell	NN
cord-343791-0vykwml5	147	11	repertoire	repertoire	NN
cord-343791-0vykwml5	147	12	upon	upon	IN
cord-343791-0vykwml5	147	13	multiple	multiple	JJ
cord-343791-0vykwml5	147	14	antigenic	antigenic	JJ
cord-343791-0vykwml5	147	15	exposures	exposure	NNS
cord-343791-0vykwml5	147	16	.	.	.
cord-343791-0vykwml5	148	1	Shortcomings	shortcoming	NNS
cord-343791-0vykwml5	148	2	of	of	IN
cord-343791-0vykwml5	148	3	VLPs	vlp	NNS
cord-343791-0vykwml5	148	4	include	include	VBP
cord-343791-0vykwml5	148	5	their	-PRON-	PRP$
cord-343791-0vykwml5	148	6	requirement	requirement	NN
cord-343791-0vykwml5	148	7	for	for	IN
cord-343791-0vykwml5	148	8	a	a	DT
cord-343791-0vykwml5	148	9	continuous	continuous	JJ
cord-343791-0vykwml5	148	10	and	and	CC
cord-343791-0vykwml5	148	11	well	well	RB
cord-343791-0vykwml5	148	12	-	-	HYPH
cord-343791-0vykwml5	148	13	regulated	regulate	VBN
cord-343791-0vykwml5	148	14	cold	cold	JJ
cord-343791-0vykwml5	148	15	chain	chain	NN
cord-343791-0vykwml5	148	16	,	,	,
cord-343791-0vykwml5	148	17	which	which	WDT
cord-343791-0vykwml5	148	18	negatively	negatively	RB
cord-343791-0vykwml5	148	19	impacts	impact	VBZ
cord-343791-0vykwml5	148	20	their	-PRON-	PRP$
cord-343791-0vykwml5	148	21	distribution	distribution	NN
cord-343791-0vykwml5	148	22	to	to	IN
cord-343791-0vykwml5	148	23	the	the	DT
cord-343791-0vykwml5	148	24	developing	develop	VBG
cord-343791-0vykwml5	148	25	world	world	NN
cord-343791-0vykwml5	148	26	.	.	.
cord-343791-0vykwml5	149	1	To	to	TO
cord-343791-0vykwml5	149	2	address	address	VB
cord-343791-0vykwml5	149	3	this	this	DT
cord-343791-0vykwml5	149	4	challenge	challenge	NN
cord-343791-0vykwml5	149	5	,	,	,
cord-343791-0vykwml5	149	6	the	the	DT
cord-343791-0vykwml5	149	7	Chackerian	chackerian	JJ
cord-343791-0vykwml5	149	8	group	group	NN
cord-343791-0vykwml5	149	9	has	have	VBZ
cord-343791-0vykwml5	149	10	developed	develop	VBN
cord-343791-0vykwml5	149	11	a	a	DT
cord-343791-0vykwml5	149	12	VLP	VLP	NNP
cord-343791-0vykwml5	149	13	-	-	HYPH
cord-343791-0vykwml5	149	14	based	base	VBN
cord-343791-0vykwml5	149	15	vaccine	vaccine	NN
cord-343791-0vykwml5	149	16	candidate	candidate	NN
cord-343791-0vykwml5	149	17	that	that	WDT
cord-343791-0vykwml5	149	18	is	be	VBZ
cord-343791-0vykwml5	149	19	compatible	compatible	JJ
cord-343791-0vykwml5	149	20	with	with	IN
cord-343791-0vykwml5	149	21	spray	spray	NN
cord-343791-0vykwml5	149	22	drying	drying	NN
cord-343791-0vykwml5	149	23	,	,	,
cord-343791-0vykwml5	149	24	thus	thus	RB
cord-343791-0vykwml5	149	25	enhancing	enhance	VBG
cord-343791-0vykwml5	149	26	its	-PRON-	PRP$
cord-343791-0vykwml5	149	27	stability	stability	NN
cord-343791-0vykwml5	149	28	over	over	IN
cord-343791-0vykwml5	149	29	a	a	DT
cord-343791-0vykwml5	149	30	broad	broad	JJ
cord-343791-0vykwml5	149	31	range	range	NN
cord-343791-0vykwml5	149	32	of	of	IN
cord-343791-0vykwml5	149	33	temperatures	temperature	NNS
cord-343791-0vykwml5	149	34	.	.	.
cord-343791-0vykwml5	150	1	[	[	-LRB-
cord-343791-0vykwml5	150	2	43	43	CD
cord-343791-0vykwml5	150	3	]	]	-RRB-
cord-343791-0vykwml5	151	1	This	this	DT
cord-343791-0vykwml5	151	2	platform	platform	NN
cord-343791-0vykwml5	151	3	targets	target	VBZ
cord-343791-0vykwml5	151	4	a	a	DT
cord-343791-0vykwml5	151	5	highly	highly	RB
cord-343791-0vykwml5	151	6	conserved	conserve	VBN
cord-343791-0vykwml5	151	7	,	,	,
cord-343791-0vykwml5	151	8	broadly	broadly	RB
cord-343791-0vykwml5	151	9	neutralizing	neutralize	VBG
cord-343791-0vykwml5	151	10	epitope	epitope	NN
cord-343791-0vykwml5	151	11	from	from	IN
cord-343791-0vykwml5	151	12	the	the	DT
cord-343791-0vykwml5	151	13	HPV	HPV	NNP
cord-343791-0vykwml5	151	14	minor	minor	JJ
cord-343791-0vykwml5	151	15	capsid	capsid	NN
cord-343791-0vykwml5	151	16	protein	protein	NN
cord-343791-0vykwml5	151	17	,	,	,
cord-343791-0vykwml5	151	18	L2	L2	NNP
cord-343791-0vykwml5	151	19	.	.	.
cord-343791-0vykwml5	152	1	Not	not	RB
cord-343791-0vykwml5	152	2	only	only	RB
cord-343791-0vykwml5	152	3	does	do	VBZ
cord-343791-0vykwml5	152	4	this	this	DT
cord-343791-0vykwml5	152	5	vaccine	vaccine	NN
cord-343791-0vykwml5	152	6	elicit	elicit	VB
cord-343791-0vykwml5	152	7	high	high	JJ
cord-343791-0vykwml5	152	8	-	-	HYPH
cord-343791-0vykwml5	152	9	titer	titer	NN
cord-343791-0vykwml5	152	10	and	and	CC
cord-343791-0vykwml5	152	11	long	long	RB
cord-343791-0vykwml5	152	12	-	-	HYPH
cord-343791-0vykwml5	152	13	lasting	last	VBG
cord-343791-0vykwml5	152	14	antibody	antibody	NN
cord-343791-0vykwml5	152	15	immune	immune	JJ
cord-343791-0vykwml5	152	16	responses	response	NNS
cord-343791-0vykwml5	152	17	,	,	,
cord-343791-0vykwml5	152	18	[	[	-LRB-
cord-343791-0vykwml5	152	19	44	44	CD
cord-343791-0vykwml5	152	20	]	]	-RRB-
cord-343791-0vykwml5	153	1	but	but	CC
cord-343791-0vykwml5	153	2	the	the	DT
cord-343791-0vykwml5	153	3	spray	spray	NN
cord-343791-0vykwml5	153	4	dried	dry	VBD
cord-343791-0vykwml5	153	5	VLPs	vlp	NNS
cord-343791-0vykwml5	153	6	were	be	VBD
cord-343791-0vykwml5	153	7	highly	highly	RB
cord-343791-0vykwml5	153	8	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	153	9	in	in	IN
cord-343791-0vykwml5	153	10	a	a	DT
cord-343791-0vykwml5	153	11	mouse	mouse	NN
cord-343791-0vykwml5	153	12	model	model	NN
cord-343791-0vykwml5	153	13	after	after	IN
cord-343791-0vykwml5	153	14	being	be	VBG
cord-343791-0vykwml5	153	15	stored	store	VBN
cord-343791-0vykwml5	153	16	for	for	IN
cord-343791-0vykwml5	153	17	14	14	CD
cord-343791-0vykwml5	153	18	months	month	NNS
cord-343791-0vykwml5	153	19	at	at	IN
cord-343791-0vykwml5	153	20	either	either	DT
cord-343791-0vykwml5	153	21	room	room	NN
cord-343791-0vykwml5	153	22	temperature	temperature	NN
cord-343791-0vykwml5	153	23	or	or	CC
cord-343791-0vykwml5	153	24	37	37	CD
cord-343791-0vykwml5	153	25	°	°	NN
cord-343791-0vykwml5	153	26	C	c	NN
cord-343791-0vykwml5	153	27	.	.	.
cord-343791-0vykwml5	154	1	Other	other	JJ
cord-343791-0vykwml5	154	2	constraints	constraint	NNS
cord-343791-0vykwml5	154	3	that	that	WDT
cord-343791-0vykwml5	154	4	VLPs	vlp	NNS
cord-343791-0vykwml5	154	5	are	be	VBP
cord-343791-0vykwml5	154	6	subject	subject	JJ
cord-343791-0vykwml5	154	7	to	to	TO
cord-343791-0vykwml5	154	8	include	include	VB
cord-343791-0vykwml5	154	9	the	the	DT
cord-343791-0vykwml5	154	10	relatively	relatively	RB
cord-343791-0vykwml5	154	11	small	small	JJ
cord-343791-0vykwml5	154	12	size	size	NN
cord-343791-0vykwml5	154	13	of	of	IN
cord-343791-0vykwml5	154	14	epitopes	epitope	NNS
cord-343791-0vykwml5	154	15	that	that	WDT
cord-343791-0vykwml5	154	16	can	can	MD
cord-343791-0vykwml5	154	17	be	be	VB
cord-343791-0vykwml5	154	18	accommodated	accommodate	VBN
cord-343791-0vykwml5	154	19	within	within	IN
cord-343791-0vykwml5	154	20	the	the	DT
cord-343791-0vykwml5	154	21	particles	particle	NNS
cord-343791-0vykwml5	154	22	.	.	.
cord-343791-0vykwml5	155	1	For	for	IN
cord-343791-0vykwml5	155	2	example	example	NN
cord-343791-0vykwml5	155	3	,	,	,
cord-343791-0vykwml5	155	4	large	large	JJ
cord-343791-0vykwml5	155	5	antigens	antigen	NNS
cord-343791-0vykwml5	155	6	such	such	JJ
cord-343791-0vykwml5	155	7	as	as	IN
cord-343791-0vykwml5	155	8	HIV	HIV	NNP
cord-343791-0vykwml5	155	9	envelope	envelope	NN
cord-343791-0vykwml5	155	10	and	and	CC
cord-343791-0vykwml5	155	11	influenza	influenza	NN
cord-343791-0vykwml5	155	12	hemagglutinin	hemagglutinin	NN
cord-343791-0vykwml5	155	13	proteins	protein	NNS
cord-343791-0vykwml5	155	14	are	be	VBP
cord-343791-0vykwml5	155	15	too	too	RB
cord-343791-0vykwml5	155	16	large	large	JJ
cord-343791-0vykwml5	155	17	to	to	TO
cord-343791-0vykwml5	155	18	be	be	VB
cord-343791-0vykwml5	155	19	packaged	package	VBN
cord-343791-0vykwml5	155	20	within	within	IN
cord-343791-0vykwml5	155	21	native	native	JJ
cord-343791-0vykwml5	155	22	VLPs	vlp	NNS
cord-343791-0vykwml5	155	23	.	.	.
cord-343791-0vykwml5	156	1	The	the	DT
cord-343791-0vykwml5	156	2	practicality	practicality	NN
cord-343791-0vykwml5	156	3	of	of	IN
cord-343791-0vykwml5	156	4	VLP	VLP	NNP
cord-343791-0vykwml5	156	5	platforms	platform	NNS
cord-343791-0vykwml5	156	6	is	be	VBZ
cord-343791-0vykwml5	156	7	also	also	RB
cord-343791-0vykwml5	156	8	limited	limit	VBN
cord-343791-0vykwml5	156	9	by	by	IN
cord-343791-0vykwml5	156	10	manufacturing	manufacture	VBG
cord-343791-0vykwml5	156	11	considerations	consideration	NNS
cord-343791-0vykwml5	156	12	.	.	.
cord-343791-0vykwml5	157	1	[	[	-LRB-
cord-343791-0vykwml5	157	2	21	21	CD
cord-343791-0vykwml5	157	3	]	]	-RRB-
cord-343791-0vykwml5	158	1	For	for	IN
cord-343791-0vykwml5	158	2	example	example	NN
cord-343791-0vykwml5	158	3	,	,	,
cord-343791-0vykwml5	158	4	VLPs	vlp	NNS
cord-343791-0vykwml5	158	5	derived	derive	VBN
cord-343791-0vykwml5	158	6	from	from	IN
cord-343791-0vykwml5	158	7	E.	E.	NNP
cord-343791-0vykwml5	158	8	coli	coli	NNS
cord-343791-0vykwml5	158	9	,	,	,
cord-343791-0vykwml5	158	10	the	the	DT
cord-343791-0vykwml5	158	11	most	most	RBS
cord-343791-0vykwml5	158	12	widely	widely	RB
cord-343791-0vykwml5	158	13	used	use	VBN
cord-343791-0vykwml5	158	14	and	and	CC
cord-343791-0vykwml5	158	15	most	most	RBS
cord-343791-0vykwml5	158	16	efficient	efficient	JJ
cord-343791-0vykwml5	158	17	expression	expression	NN
cord-343791-0vykwml5	158	18	system	system	NN
cord-343791-0vykwml5	158	19	in	in	IN
cord-343791-0vykwml5	158	20	the	the	DT
cord-343791-0vykwml5	158	21	biotechnology	biotechnology	NN
cord-343791-0vykwml5	158	22	industry	industry	NN
cord-343791-0vykwml5	158	23	,	,	,
cord-343791-0vykwml5	158	24	have	have	VBP
cord-343791-0vykwml5	158	25	a	a	DT
cord-343791-0vykwml5	158	26	high	high	JJ
cord-343791-0vykwml5	158	27	degree	degree	NN
cord-343791-0vykwml5	158	28	of	of	IN
cord-343791-0vykwml5	158	29	heterogeneity	heterogeneity	NN
cord-343791-0vykwml5	158	30	in	in	IN
cord-343791-0vykwml5	158	31	their	-PRON-	PRP$
cord-343791-0vykwml5	158	32	physical	physical	JJ
cord-343791-0vykwml5	158	33	properties	property	NNS
cord-343791-0vykwml5	158	34	,	,	,
cord-343791-0vykwml5	158	35	including	include	VBG
cord-343791-0vykwml5	158	36	the	the	DT
cord-343791-0vykwml5	158	37	shape	shape	NN
cord-343791-0vykwml5	158	38	and	and	CC
cord-343791-0vykwml5	158	39	diameter	diameter	NN
cord-343791-0vykwml5	158	40	of	of	IN
cord-343791-0vykwml5	158	41	the	the	DT
cord-343791-0vykwml5	158	42	particles	particle	NNS
cord-343791-0vykwml5	158	43	.	.	.
cord-343791-0vykwml5	159	1	Such	such	JJ
cord-343791-0vykwml5	159	2	particles	particle	NNS
cord-343791-0vykwml5	159	3	require	require	VBP
cord-343791-0vykwml5	159	4	post	post	JJ
cord-343791-0vykwml5	159	5	-	-	JJ
cord-343791-0vykwml5	159	6	purification	purification	JJ
cord-343791-0vykwml5	159	7	disassembly	disassembly	NN
cord-343791-0vykwml5	159	8	and	and	CC
cord-343791-0vykwml5	159	9	reassembly	reassembly	RB
cord-343791-0vykwml5	159	10	in	in	IN
cord-343791-0vykwml5	159	11	optimized	optimize	VBN
cord-343791-0vykwml5	159	12	conditions	condition	NNS
cord-343791-0vykwml5	159	13	.	.	.
cord-343791-0vykwml5	160	1	In	in	IN
cord-343791-0vykwml5	160	2	addition	addition	NN
cord-343791-0vykwml5	160	3	,	,	,
cord-343791-0vykwml5	160	4	it	-PRON-	PRP
cord-343791-0vykwml5	160	5	may	may	MD
cord-343791-0vykwml5	160	6	be	be	VB
cord-343791-0vykwml5	160	7	possible	possible	JJ
cord-343791-0vykwml5	160	8	to	to	TO
cord-343791-0vykwml5	160	9	produce	produce	VB
cord-343791-0vykwml5	160	10	highly	highly	RB
cord-343791-0vykwml5	160	11	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	160	12	VLP	VLP	NNP
cord-343791-0vykwml5	160	13	preparations	preparation	NNS
cord-343791-0vykwml5	160	14	,	,	,
cord-343791-0vykwml5	160	15	but	but	CC
cord-343791-0vykwml5	160	16	the	the	DT
cord-343791-0vykwml5	160	17	antigen	antigen	NN
cord-343791-0vykwml5	160	18	might	may	MD
cord-343791-0vykwml5	160	19	not	not	RB
cord-343791-0vykwml5	160	20	be	be	VB
cord-343791-0vykwml5	160	21	viable	viable	JJ
cord-343791-0vykwml5	160	22	in	in	IN
cord-343791-0vykwml5	160	23	the	the	DT
cord-343791-0vykwml5	160	24	VLP	VLP	NNP
cord-343791-0vykwml5	160	25	context	context	NN
cord-343791-0vykwml5	160	26	until	until	IN
cord-343791-0vykwml5	160	27	stable	stable	JJ
cord-343791-0vykwml5	160	28	formulations	formulation	NNS
cord-343791-0vykwml5	160	29	can	can	MD
cord-343791-0vykwml5	160	30	be	be	VB
cord-343791-0vykwml5	160	31	developed	develop	VBN
cord-343791-0vykwml5	160	32	.	.	.
cord-343791-0vykwml5	161	1	Formulations	formulation	NNS
cord-343791-0vykwml5	161	2	must	must	MD
cord-343791-0vykwml5	161	3	be	be	VB
cord-343791-0vykwml5	161	4	resistant	resistant	JJ
cord-343791-0vykwml5	161	5	to	to	IN
cord-343791-0vykwml5	161	6	aggregation	aggregation	NN
cord-343791-0vykwml5	161	7	upon	upon	IN
cord-343791-0vykwml5	161	8	exposure	exposure	NN
cord-343791-0vykwml5	161	9	to	to	IN
cord-343791-0vykwml5	161	10	low	low	JJ
cord-343791-0vykwml5	161	11	salt	salt	NN
cord-343791-0vykwml5	161	12	and	and	CC
cord-343791-0vykwml5	161	13	protein	protein	NN
cord-343791-0vykwml5	161	14	concentration	concentration	NN
cord-343791-0vykwml5	161	15	,	,	,
cord-343791-0vykwml5	161	16	as	as	RB
cord-343791-0vykwml5	161	17	well	well	RB
cord-343791-0vykwml5	161	18	as	as	IN
cord-343791-0vykwml5	161	19	protection	protection	NN
cord-343791-0vykwml5	161	20	against	against	IN
cord-343791-0vykwml5	161	21	surface	surface	NN
cord-343791-0vykwml5	161	22	adsorption	adsorption	NN
cord-343791-0vykwml5	161	23	and	and	CC
cord-343791-0vykwml5	161	24	aggregation	aggregation	NN
cord-343791-0vykwml5	161	25	as	as	IN
cord-343791-0vykwml5	161	26	a	a	DT
cord-343791-0vykwml5	161	27	result	result	NN
cord-343791-0vykwml5	161	28	of	of	IN
cord-343791-0vykwml5	161	29	heat	heat	NN
cord-343791-0vykwml5	161	30	stress	stress	NN
cord-343791-0vykwml5	161	31	and	and	CC
cord-343791-0vykwml5	161	32	physical	physical	JJ
cord-343791-0vykwml5	161	33	agitation	agitation	NN
cord-343791-0vykwml5	161	34	in	in	IN
cord-343791-0vykwml5	161	35	order	order	NN
cord-343791-0vykwml5	161	36	to	to	TO
cord-343791-0vykwml5	161	37	achieve	achieve	VB
cord-343791-0vykwml5	161	38	the	the	DT
cord-343791-0vykwml5	161	39	multiple	multiple	JJ
cord-343791-0vykwml5	161	40	-	-	HYPH
cord-343791-0vykwml5	161	41	year	year	NN
cord-343791-0vykwml5	161	42	stability	stability	NN
cord-343791-0vykwml5	161	43	required	require	VBN
cord-343791-0vykwml5	161	44	for	for	IN
cord-343791-0vykwml5	161	45	a	a	DT
cord-343791-0vykwml5	161	46	marketed	market	VBN
cord-343791-0vykwml5	161	47	vaccine	vaccine	NN
cord-343791-0vykwml5	161	48	.	.	.
cord-343791-0vykwml5	162	1	[	[	-LRB-
cord-343791-0vykwml5	162	2	20	20	CD
cord-343791-0vykwml5	162	3	]	]	-RRB-
cord-343791-0vykwml5	162	4	Newer	new	JJR
cord-343791-0vykwml5	162	5	expression	expression	NN
cord-343791-0vykwml5	162	6	systems	system	NNS
cord-343791-0vykwml5	162	7	in	in	IN
cord-343791-0vykwml5	162	8	conjunction	conjunction	NN
cord-343791-0vykwml5	162	9	with	with	IN
cord-343791-0vykwml5	162	10	innovative	innovative	JJ
cord-343791-0vykwml5	162	11	purification	purification	NN
cord-343791-0vykwml5	162	12	strategies	strategy	NNS
cord-343791-0vykwml5	162	13	could	could	MD
cord-343791-0vykwml5	162	14	determine	determine	VB
cord-343791-0vykwml5	162	15	the	the	DT
cord-343791-0vykwml5	162	16	pace	pace	NN
cord-343791-0vykwml5	162	17	for	for	IN
cord-343791-0vykwml5	162	18	the	the	DT
cord-343791-0vykwml5	162	19	next	next	JJ
cord-343791-0vykwml5	162	20	generation	generation	NN
cord-343791-0vykwml5	162	21	of	of	IN
cord-343791-0vykwml5	162	22	VLP	VLP	NNP
cord-343791-0vykwml5	162	23	-	-	HYPH
cord-343791-0vykwml5	162	24	based	base	VBN
cord-343791-0vykwml5	162	25	vaccine	vaccine	NN
cord-343791-0vykwml5	162	26	candidates	candidate	NNS
cord-343791-0vykwml5	162	27	.	.	.
cord-343791-0vykwml5	163	1	For	for	IN
cord-343791-0vykwml5	163	2	example	example	NN
cord-343791-0vykwml5	163	3	,	,	,
cord-343791-0vykwml5	163	4	yeast	yeast	NN
cord-343791-0vykwml5	163	5	,	,	,
cord-343791-0vykwml5	163	6	insect	insect	NN
cord-343791-0vykwml5	163	7	,	,	,
cord-343791-0vykwml5	163	8	and	and	CC
cord-343791-0vykwml5	163	9	mammalian	mammalian	JJ
cord-343791-0vykwml5	163	10	expression	expression	NN
cord-343791-0vykwml5	163	11	systems	system	NNS
cord-343791-0vykwml5	163	12	have	have	VBP
cord-343791-0vykwml5	163	13	been	be	VBN
cord-343791-0vykwml5	163	14	used	use	VBN
cord-343791-0vykwml5	163	15	to	to	TO
cord-343791-0vykwml5	163	16	circumvent	circumvent	VB
cord-343791-0vykwml5	163	17	the	the	DT
cord-343791-0vykwml5	163	18	limitations	limitation	NNS
cord-343791-0vykwml5	163	19	of	of	IN
cord-343791-0vykwml5	163	20	bacterial	bacterial	JJ
cord-343791-0vykwml5	163	21	expression	expression	NN
cord-343791-0vykwml5	163	22	such	such	JJ
cord-343791-0vykwml5	163	23	as	as	IN
cord-343791-0vykwml5	163	24	sub	sub	JJ
cord-343791-0vykwml5	163	25	-	-	JJ
cord-343791-0vykwml5	163	26	optimal	optimal	JJ
cord-343791-0vykwml5	163	27	pH	ph	NN
cord-343791-0vykwml5	163	28	and	and	CC
cord-343791-0vykwml5	163	29	lipid	lipid	NN
cord-343791-0vykwml5	163	30	compositions	composition	NNS
cord-343791-0vykwml5	163	31	within	within	IN
cord-343791-0vykwml5	163	32	the	the	DT
cord-343791-0vykwml5	163	33	bacteria	bacteria	NNS
cord-343791-0vykwml5	163	34	.	.	.
cord-343791-0vykwml5	164	1	Additionally	additionally	RB
cord-343791-0vykwml5	164	2	,	,	,
cord-343791-0vykwml5	164	3	the	the	DT
cord-343791-0vykwml5	164	4	advancement	advancement	NN
cord-343791-0vykwml5	164	5	of	of	IN
cord-343791-0vykwml5	164	6	high	high	JJ
cord-343791-0vykwml5	164	7	-	-	HYPH
cord-343791-0vykwml5	164	8	throughput	throughput	NN
cord-343791-0vykwml5	164	9	biophysical	biophysical	JJ
cord-343791-0vykwml5	164	10	and	and	CC
cord-343791-0vykwml5	164	11	structural	structural	JJ
cord-343791-0vykwml5	164	12	analyses	analysis	NNS
cord-343791-0vykwml5	164	13	of	of	IN
cord-343791-0vykwml5	164	14	recombinant	recombinant	JJ
cord-343791-0vykwml5	164	15	VLPs	vlp	NNS
cord-343791-0vykwml5	164	16	may	may	MD
cord-343791-0vykwml5	164	17	play	play	VB
cord-343791-0vykwml5	164	18	a	a	DT
cord-343791-0vykwml5	164	19	key	key	JJ
cord-343791-0vykwml5	164	20	role	role	NN
cord-343791-0vykwml5	164	21	in	in	IN
cord-343791-0vykwml5	164	22	the	the	DT
cord-343791-0vykwml5	164	23	assessment	assessment	NN
cord-343791-0vykwml5	164	24	of	of	IN
cord-343791-0vykwml5	164	25	VLP	VLP	NNP
cord-343791-0vykwml5	164	26	candidates	candidate	NNS
cord-343791-0vykwml5	164	27	.	.	.
cord-343791-0vykwml5	165	1	Electron	electron	NN
cord-343791-0vykwml5	165	2	microscopy	microscopy	NN
cord-343791-0vykwml5	165	3	,	,	,
cord-343791-0vykwml5	165	4	electrospray	electrospray	JJ
cord-343791-0vykwml5	165	5	differential	differential	JJ
cord-343791-0vykwml5	165	6	mobility	mobility	NN
cord-343791-0vykwml5	165	7	analysis	analysis	NN
cord-343791-0vykwml5	165	8	,	,	,
cord-343791-0vykwml5	165	9	atomic	atomic	JJ
cord-343791-0vykwml5	165	10	force	force	NN
cord-343791-0vykwml5	165	11	microscopy	microscopy	NN
cord-343791-0vykwml5	165	12	,	,	,
cord-343791-0vykwml5	165	13	X	x	NN
cord-343791-0vykwml5	165	14	-	-	NN
cord-343791-0vykwml5	165	15	ray	ray	NN
cord-343791-0vykwml5	165	16	crystallography	crystallography	NN
cord-343791-0vykwml5	165	17	,	,	,
cord-343791-0vykwml5	165	18	and	and	CC
cord-343791-0vykwml5	165	19	dynamic	dynamic	JJ
cord-343791-0vykwml5	165	20	light	light	JJ
cord-343791-0vykwml5	165	21	scattering	scattering	NN
cord-343791-0vykwml5	165	22	provide	provide	VB
cord-343791-0vykwml5	165	23	quantitative	quantitative	JJ
cord-343791-0vykwml5	165	24	structural	structural	JJ
cord-343791-0vykwml5	165	25	data	datum	NNS
cord-343791-0vykwml5	165	26	for	for	IN
cord-343791-0vykwml5	165	27	each	each	DT
cord-343791-0vykwml5	165	28	vaccine	vaccine	NN
cord-343791-0vykwml5	165	29	candidate	candidate	NN
cord-343791-0vykwml5	165	30	and	and	CC
cord-343791-0vykwml5	165	31	play	play	VB
cord-343791-0vykwml5	165	32	a	a	DT
cord-343791-0vykwml5	165	33	valuable	valuable	JJ
cord-343791-0vykwml5	165	34	role	role	NN
cord-343791-0vykwml5	165	35	in	in	IN
cord-343791-0vykwml5	165	36	ensuring	ensure	VBG
cord-343791-0vykwml5	165	37	product	product	NN
cord-343791-0vykwml5	165	38	robustness	robustness	NN
cord-343791-0vykwml5	165	39	from	from	IN
cord-343791-0vykwml5	165	40	the	the	DT
cord-343791-0vykwml5	165	41	early	early	JJ
cord-343791-0vykwml5	165	42	clinical	clinical	JJ
cord-343791-0vykwml5	165	43	development	development	NN
cord-343791-0vykwml5	165	44	stage	stage	NN
cord-343791-0vykwml5	165	45	and	and	CC
cord-343791-0vykwml5	165	46	beyond	beyond	IN
cord-343791-0vykwml5	165	47	.	.	.
cord-343791-0vykwml5	166	1	[	[	-LRB-
cord-343791-0vykwml5	166	2	20	20	CD
cord-343791-0vykwml5	166	3	]	]	-RRB-
cord-343791-0vykwml5	166	4	 	 	_SP
cord-343791-0vykwml5	166	5	As	as	IN
cord-343791-0vykwml5	166	6	an	an	DT
cord-343791-0vykwml5	166	7	alternative	alternative	NN
cord-343791-0vykwml5	166	8	to	to	IN
cord-343791-0vykwml5	166	9	particles	particle	NNS
cord-343791-0vykwml5	166	10	inspired	inspire	VBN
cord-343791-0vykwml5	166	11	by	by	IN
cord-343791-0vykwml5	166	12	natural	natural	JJ
cord-343791-0vykwml5	166	13	virus	virus	NN
cord-343791-0vykwml5	166	14	capsid	capsid	NN
cord-343791-0vykwml5	166	15	proteins	protein	NNS
cord-343791-0vykwml5	166	16	,	,	,
cord-343791-0vykwml5	166	17	fully	fully	RB
cord-343791-0vykwml5	166	18	designed	design	VBN
cord-343791-0vykwml5	166	19	protein	protein	NN
cord-343791-0vykwml5	166	20	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	166	21	have	have	VBP
cord-343791-0vykwml5	166	22	received	receive	VBN
cord-343791-0vykwml5	166	23	considerable	considerable	JJ
cord-343791-0vykwml5	166	24	interest	interest	NN
cord-343791-0vykwml5	166	25	.	.	.
cord-343791-0vykwml5	167	1	Although	although	IN
cord-343791-0vykwml5	167	2	"	"	``
cord-343791-0vykwml5	167	3	bottom	bottom	NN
cord-343791-0vykwml5	167	4	-	-	HYPH
cord-343791-0vykwml5	167	5	up	up	NN
cord-343791-0vykwml5	167	6	"	"	''
cord-343791-0vykwml5	167	7	approaches	approach	NNS
cord-343791-0vykwml5	167	8	for	for	IN
cord-343791-0vykwml5	167	9	designing	design	VBG
cord-343791-0vykwml5	167	10	nanomaterials	nanomaterial	NNS
cord-343791-0vykwml5	167	11	were	be	VBD
cord-343791-0vykwml5	167	12	popularized	popularize	VBN
cord-343791-0vykwml5	167	13	over	over	IN
cord-343791-0vykwml5	167	14	30	30	CD
cord-343791-0vykwml5	167	15	years	year	NNS
cord-343791-0vykwml5	167	16	ago	ago	RB
cord-343791-0vykwml5	167	17	,	,	,
cord-343791-0vykwml5	167	18	[	[	-LRB-
cord-343791-0vykwml5	167	19	45	45	CD
cord-343791-0vykwml5	167	20	]	]	-RRB-
cord-343791-0vykwml5	167	21	the	the	DT
cord-343791-0vykwml5	167	22	development	development	NN
cord-343791-0vykwml5	167	23	of	of	IN
cord-343791-0vykwml5	167	24	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	167	25	polypeptide	polypeptide	NN
cord-343791-0vykwml5	167	26	materials	material	NNS
cord-343791-0vykwml5	167	27	into	into	IN
cord-343791-0vykwml5	167	28	successful	successful	JJ
cord-343791-0vykwml5	167	29	medical	medical	JJ
cord-343791-0vykwml5	167	30	technologies	technology	NNS
cord-343791-0vykwml5	167	31	was	be	VBD
cord-343791-0vykwml5	167	32	initially	initially	RB
cord-343791-0vykwml5	167	33	slow	slow	JJ
cord-343791-0vykwml5	167	34	,	,	,
cord-343791-0vykwml5	167	35	hindered	hinder	VBN
cord-343791-0vykwml5	167	36	by	by	IN
cord-343791-0vykwml5	167	37	the	the	DT
cord-343791-0vykwml5	167	38	sheer	sheer	JJ
cord-343791-0vykwml5	167	39	diversity	diversity	NN
cord-343791-0vykwml5	167	40	of	of	IN
cord-343791-0vykwml5	167	41	possible	possible	JJ
cord-343791-0vykwml5	167	42	self	self	NN
cord-343791-0vykwml5	167	43	-	-	HYPH
cord-343791-0vykwml5	167	44	assembled	assemble	VBN
cord-343791-0vykwml5	167	45	structures	structure	NNS
cord-343791-0vykwml5	167	46	and	and	CC
cord-343791-0vykwml5	167	47	the	the	DT
cord-343791-0vykwml5	167	48	lack	lack	NN
cord-343791-0vykwml5	167	49	of	of	IN
cord-343791-0vykwml5	167	50	design	design	NN
cord-343791-0vykwml5	167	51	rules	rule	NNS
cord-343791-0vykwml5	167	52	.	.	.
cord-343791-0vykwml5	168	1	In	in	IN
cord-343791-0vykwml5	168	2	2001	2001	CD
cord-343791-0vykwml5	168	3	,	,	,
cord-343791-0vykwml5	168	4	the	the	DT
cord-343791-0vykwml5	168	5	Yeates	Yeates	NNPS
cord-343791-0vykwml5	168	6	group	group	NN
cord-343791-0vykwml5	168	7	developed	develop	VBD
cord-343791-0vykwml5	168	8	an	an	DT
cord-343791-0vykwml5	168	9	approach	approach	NN
cord-343791-0vykwml5	168	10	based	base	VBN
cord-343791-0vykwml5	168	11	on	on	IN
cord-343791-0vykwml5	168	12	molecular	molecular	JJ
cord-343791-0vykwml5	168	13	symmetry	symmetry	NN
cord-343791-0vykwml5	168	14	to	to	TO
cord-343791-0vykwml5	168	15	fabricate	fabricate	VB
cord-343791-0vykwml5	168	16	protein	protein	NN
cord-343791-0vykwml5	168	17	assemblies	assembly	NNS
cord-343791-0vykwml5	168	18	having	have	VBG
cord-343791-0vykwml5	168	19	a	a	DT
cord-343791-0vykwml5	168	20	range	range	NN
cord-343791-0vykwml5	168	21	of	of	IN
cord-343791-0vykwml5	168	22	predictable	predictable	JJ
cord-343791-0vykwml5	168	23	architectures	architecture	NNS
cord-343791-0vykwml5	168	24	.	.	.
cord-343791-0vykwml5	169	1	[	[	-LRB-
cord-343791-0vykwml5	169	2	46	46	CD
cord-343791-0vykwml5	169	3	]	]	-RRB-
cord-343791-0vykwml5	170	1	Their	-PRON-	PRP$
cord-343791-0vykwml5	170	2	strategy	strategy	NN
cord-343791-0vykwml5	170	3	was	be	VBD
cord-343791-0vykwml5	170	4	a	a	DT
cord-343791-0vykwml5	170	5	breakthrough	breakthrough	NN
cord-343791-0vykwml5	170	6	in	in	IN
cord-343791-0vykwml5	170	7	rational	rational	JJ
cord-343791-0vykwml5	170	8	self	self	NN
cord-343791-0vykwml5	170	9	-	-	HYPH
cord-343791-0vykwml5	170	10	assembling	assemble	VBG
cord-343791-0vykwml5	170	11	protein	protein	NN
cord-343791-0vykwml5	170	12	design	design	NN
cord-343791-0vykwml5	170	13	.	.	.
cord-343791-0vykwml5	171	1	In	in	IN
cord-343791-0vykwml5	171	2	the	the	DT
cord-343791-0vykwml5	171	3	past	past	JJ
cord-343791-0vykwml5	171	4	few	few	JJ
cord-343791-0vykwml5	171	5	years	year	NNS
cord-343791-0vykwml5	171	6	,	,	,
cord-343791-0vykwml5	171	7	the	the	DT
cord-343791-0vykwml5	171	8	capacity	capacity	NN
cord-343791-0vykwml5	171	9	to	to	TO
cord-343791-0vykwml5	171	10	model	model	VB
cord-343791-0vykwml5	171	11	and	and	CC
cord-343791-0vykwml5	171	12	predict	predict	VB
cord-343791-0vykwml5	171	13	protein	protein	NN
cord-343791-0vykwml5	171	14	structures	structure	NNS
cord-343791-0vykwml5	171	15	and	and	CC
cord-343791-0vykwml5	171	16	energetics	energetic	NNS
cord-343791-0vykwml5	171	17	has	have	VBZ
cord-343791-0vykwml5	171	18	increased	increase	VBN
cord-343791-0vykwml5	171	19	along	along	RB
cord-343791-0vykwml5	171	20	with	with	IN
cord-343791-0vykwml5	171	21	computing	compute	VBG
cord-343791-0vykwml5	171	22	power	power	NN
cord-343791-0vykwml5	171	23	,	,	,
cord-343791-0vykwml5	171	24	leading	lead	VBG
cord-343791-0vykwml5	171	25	to	to	IN
cord-343791-0vykwml5	171	26	the	the	DT
cord-343791-0vykwml5	171	27	computational	computational	JJ
cord-343791-0vykwml5	171	28	design	design	NN
cord-343791-0vykwml5	171	29	of	of	IN
cord-343791-0vykwml5	171	30	de	de	NNP
cord-343791-0vykwml5	171	31	novo	novo	NNP
cord-343791-0vykwml5	171	32	self	self	NN
cord-343791-0vykwml5	171	33	-	-	HYPH
cord-343791-0vykwml5	171	34	assembling	assemble	VBG
cord-343791-0vykwml5	171	35	protein	protein	NN
cord-343791-0vykwml5	171	36	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	171	37	.	.	.
cord-343791-0vykwml5	172	1	[	[	-LRB-
cord-343791-0vykwml5	172	2	47	47	CD
cord-343791-0vykwml5	172	3	]	]	-RRB-
cord-343791-0vykwml5	173	1	The	the	DT
cord-343791-0vykwml5	173	2	Baker	Baker	NNP
cord-343791-0vykwml5	173	3	group	group	NN
cord-343791-0vykwml5	173	4	used	use	VBD
cord-343791-0vykwml5	173	5	naturally	naturally	RB
cord-343791-0vykwml5	173	6	occurring	occur	VBG
cord-343791-0vykwml5	173	7	oligomeric	oligomeric	JJ
cord-343791-0vykwml5	173	8	proteins	protein	NNS
cord-343791-0vykwml5	173	9	as	as	IN
cord-343791-0vykwml5	173	10	building	building	NN
cord-343791-0vykwml5	173	11	blocks	block	NNS
cord-343791-0vykwml5	173	12	to	to	IN
cord-343791-0vykwml5	173	13	design	design	VB
cord-343791-0vykwml5	173	14	cage	cage	NN
cord-343791-0vykwml5	173	15	-	-	HYPH
cord-343791-0vykwml5	173	16	like	like	JJ
cord-343791-0vykwml5	173	17	assemblies	assembly	NNS
cord-343791-0vykwml5	173	18	with	with	IN
cord-343791-0vykwml5	173	19	accuracy	accuracy	NN
cord-343791-0vykwml5	173	20	.	.	.
cord-343791-0vykwml5	174	1	Recently	recently	RB
cord-343791-0vykwml5	174	2	,	,	,
cord-343791-0vykwml5	174	3	they	-PRON-	PRP
cord-343791-0vykwml5	174	4	generated	generate	VBD
cord-343791-0vykwml5	174	5	a	a	DT
cord-343791-0vykwml5	174	6	hyperstable	hyperstable	JJ
cord-343791-0vykwml5	174	7	60-subunit	60-subunit	CD
cord-343791-0vykwml5	174	8	protein	protein	NN
cord-343791-0vykwml5	174	9	icosahedron	icosahedron	NN
cord-343791-0vykwml5	174	10	via	via	IN
cord-343791-0vykwml5	174	11	symmetric	symmetric	JJ
cord-343791-0vykwml5	174	12	modelling	modelling	NN
cord-343791-0vykwml5	174	13	coupled	couple	VBN
cord-343791-0vykwml5	174	14	with	with	IN
cord-343791-0vykwml5	174	15	computational	computational	JJ
cord-343791-0vykwml5	174	16	protein	protein	NN
cord-343791-0vykwml5	174	17	-	-	HYPH
cord-343791-0vykwml5	174	18	protein	protein	NN
cord-343791-0vykwml5	174	19	interface	interface	NN
cord-343791-0vykwml5	174	20	design	design	NN
cord-343791-0vykwml5	174	21	.	.	.
cord-343791-0vykwml5	175	1	[	[	-LRB-
cord-343791-0vykwml5	175	2	48	48	CD
cord-343791-0vykwml5	175	3	]	]	-RRB-
cord-343791-0vykwml5	176	1	This	this	DT
cord-343791-0vykwml5	176	2	structure	structure	NN
cord-343791-0vykwml5	176	3	is	be	VBZ
cord-343791-0vykwml5	176	4	robust	robust	JJ
cord-343791-0vykwml5	176	5	to	to	IN
cord-343791-0vykwml5	176	6	genetic	genetic	JJ
cord-343791-0vykwml5	176	7	fusions	fusion	NNS
cord-343791-0vykwml5	176	8	,	,	,
cord-343791-0vykwml5	176	9	making	make	VBG
cord-343791-0vykwml5	176	10	it	-PRON-	PRP
cord-343791-0vykwml5	176	11	a	a	DT
cord-343791-0vykwml5	176	12	notably	notably	RB
cord-343791-0vykwml5	176	13	modular	modular	JJ
cord-343791-0vykwml5	176	14	platform	platform	NN
cord-343791-0vykwml5	176	15	that	that	WDT
cord-343791-0vykwml5	176	16	could	could	MD
cord-343791-0vykwml5	176	17	be	be	VB
cord-343791-0vykwml5	176	18	used	use	VBN
cord-343791-0vykwml5	176	19	in	in	IN
cord-343791-0vykwml5	176	20	multivalent	multivalent	JJ
cord-343791-0vykwml5	176	21	epitope	epitope	NN
cord-343791-0vykwml5	176	22	display	display	NN
cord-343791-0vykwml5	176	23	as	as	RB
cord-343791-0vykwml5	176	24	well	well	RB
cord-343791-0vykwml5	176	25	as	as	IN
cord-343791-0vykwml5	176	26	drug	drug	NN
cord-343791-0vykwml5	176	27	delivery	delivery	NN
cord-343791-0vykwml5	176	28	.	.	.
cord-343791-0vykwml5	177	1	Taking	take	VBG
cord-343791-0vykwml5	177	2	inspiration	inspiration	NN
cord-343791-0vykwml5	177	3	from	from	IN
cord-343791-0vykwml5	177	4	nature	nature	NN
cord-343791-0vykwml5	177	5	has	have	VBZ
cord-343791-0vykwml5	177	6	also	also	RB
cord-343791-0vykwml5	177	7	proven	prove	VBN
cord-343791-0vykwml5	177	8	invaluable	invaluable	JJ
cord-343791-0vykwml5	177	9	in	in	IN
cord-343791-0vykwml5	177	10	the	the	DT
cord-343791-0vykwml5	177	11	design	design	NN
cord-343791-0vykwml5	177	12	of	of	IN
cord-343791-0vykwml5	177	13	mechanically	mechanically	RB
cord-343791-0vykwml5	177	14	and	and	CC
cord-343791-0vykwml5	177	15	chemically	chemically	RB
cord-343791-0vykwml5	177	16	stable	stable	JJ
cord-343791-0vykwml5	177	17	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	177	18	.	.	.
cord-343791-0vykwml5	178	1	In	in	IN
cord-343791-0vykwml5	178	2	2006	2006	CD
cord-343791-0vykwml5	178	3	,	,	,
cord-343791-0vykwml5	178	4	Raman	Raman	NNP
cord-343791-0vykwml5	178	5	et	et	NNP
cord-343791-0vykwml5	178	6	al	al	NNP
cord-343791-0vykwml5	178	7	.	.	NNP
cord-343791-0vykwml5	178	8	designed	design	VBD
cord-343791-0vykwml5	178	9	a	a	DT
cord-343791-0vykwml5	178	10	self	self	NN
cord-343791-0vykwml5	178	11	-	-	HYPH
cord-343791-0vykwml5	178	12	assembling	assemble	VBG
cord-343791-0vykwml5	178	13	nanoparticle	nanoparticle	NN
cord-343791-0vykwml5	178	14	based	base	VBN
cord-343791-0vykwml5	178	15	on	on	IN
cord-343791-0vykwml5	178	16	virus	virus	NN
cord-343791-0vykwml5	178	17	capsids	capsid	VBZ
cord-343791-0vykwml5	178	18	via	via	IN
cord-343791-0vykwml5	178	19	superposition	superposition	NN
cord-343791-0vykwml5	178	20	of	of	IN
cord-343791-0vykwml5	178	21	different	different	JJ
cord-343791-0vykwml5	178	22	protein	protein	NN
cord-343791-0vykwml5	178	23	oligomerization	oligomerization	NN
cord-343791-0vykwml5	178	24	domains	domain	NNS
cord-343791-0vykwml5	178	25	onto	onto	IN
cord-343791-0vykwml5	178	26	the	the	DT
cord-343791-0vykwml5	178	27	symmetry	symmetry	NN
cord-343791-0vykwml5	178	28	axes	axis	NNS
cord-343791-0vykwml5	178	29	of	of	IN
cord-343791-0vykwml5	178	30	an	an	DT
cord-343791-0vykwml5	178	31	icosahedron	icosahedron	NN
cord-343791-0vykwml5	178	32	shown	show	VBN
cord-343791-0vykwml5	178	33	in	in	IN
cord-343791-0vykwml5	178	34	Figure	figure	NN
cord-343791-0vykwml5	178	35	1B	1b	CD
cord-343791-0vykwml5	178	36	.	.	.
cord-343791-0vykwml5	179	1	The	the	DT
cord-343791-0vykwml5	179	2	monomer	monomer	NN
cord-343791-0vykwml5	179	3	building	building	NN
cord-343791-0vykwml5	179	4	block	block	NN
cord-343791-0vykwml5	179	5	consisted	consist	VBD
cord-343791-0vykwml5	179	6	of	of	IN
cord-343791-0vykwml5	179	7	a	a	DT
cord-343791-0vykwml5	179	8	protein	protein	NN
cord-343791-0vykwml5	179	9	chain	chain	NN
cord-343791-0vykwml5	179	10	made	make	VBN
cord-343791-0vykwml5	179	11	of	of	IN
cord-343791-0vykwml5	179	12	two	two	CD
cord-343791-0vykwml5	179	13	coiled	coiled	JJ
cord-343791-0vykwml5	179	14	coils	coil	NNS
cord-343791-0vykwml5	179	15	connected	connect	VBN
cord-343791-0vykwml5	179	16	by	by	IN
cord-343791-0vykwml5	179	17	a	a	DT
cord-343791-0vykwml5	179	18	short	short	JJ
cord-343791-0vykwml5	179	19	linker	linker	NN
cord-343791-0vykwml5	179	20	region	region	NN
cord-343791-0vykwml5	179	21	.	.	.
cord-343791-0vykwml5	180	1	The	the	DT
cord-343791-0vykwml5	180	2	association	association	NN
cord-343791-0vykwml5	180	3	between	between	IN
cord-343791-0vykwml5	180	4	the	the	DT
cord-343791-0vykwml5	180	5	coiled	coiled	JJ
cord-343791-0vykwml5	180	6	coils	coil	NNS
cord-343791-0vykwml5	180	7	caused	cause	VBD
cord-343791-0vykwml5	180	8	the	the	DT
cord-343791-0vykwml5	180	9	assembly	assembly	NN
cord-343791-0vykwml5	180	10	of	of	IN
cord-343791-0vykwml5	180	11	monomers	monomer	NNS
cord-343791-0vykwml5	180	12	into	into	IN
cord-343791-0vykwml5	180	13	a	a	DT
cord-343791-0vykwml5	180	14	roughly	roughly	RB
cord-343791-0vykwml5	180	15	spherical	spherical	JJ
cord-343791-0vykwml5	180	16	nanoparticle	nanoparticle	NN
cord-343791-0vykwml5	180	17	.	.	.
cord-343791-0vykwml5	181	1	[	[	-LRB-
cord-343791-0vykwml5	181	2	9	9	CD
cord-343791-0vykwml5	181	3	]	]	-RRB-
cord-343791-0vykwml5	182	1	The	the	DT
cord-343791-0vykwml5	182	2	self	self	NN
cord-343791-0vykwml5	182	3	-	-	HYPH
cord-343791-0vykwml5	182	4	assembling	assemble	VBG
cord-343791-0vykwml5	182	5	protein	protein	NN
cord-343791-0vykwml5	182	6	nanoparticle	nanoparticle	NN
cord-343791-0vykwml5	182	7	's	's	POS
cord-343791-0vykwml5	182	8	versatile	versatile	JJ
cord-343791-0vykwml5	182	9	and	and	CC
cord-343791-0vykwml5	182	10	flexible	flexible	JJ
cord-343791-0vykwml5	182	11	design	design	NN
cord-343791-0vykwml5	182	12	allow	allow	VBP
cord-343791-0vykwml5	182	13	for	for	IN
cord-343791-0vykwml5	182	14	optimization	optimization	NN
cord-343791-0vykwml5	182	15	of	of	IN
cord-343791-0vykwml5	182	16	biophysical	biophysical	JJ
cord-343791-0vykwml5	182	17	and	and	CC
cord-343791-0vykwml5	182	18	immunological	immunological	JJ
cord-343791-0vykwml5	182	19	properties	property	NNS
cord-343791-0vykwml5	182	20	making	make	VBG
cord-343791-0vykwml5	182	21	them	-PRON-	PRP
cord-343791-0vykwml5	182	22	a	a	DT
cord-343791-0vykwml5	182	23	desirable	desirable	JJ
cord-343791-0vykwml5	182	24	vaccine	vaccine	NN
cord-343791-0vykwml5	182	25	platform	platform	NN
cord-343791-0vykwml5	182	26	.	.	.
cord-343791-0vykwml5	183	1	Whereas	whereas	IN
cord-343791-0vykwml5	183	2	synthetic	synthetic	JJ
cord-343791-0vykwml5	183	3	peptides	peptide	NNS
cord-343791-0vykwml5	183	4	are	be	VBP
cord-343791-0vykwml5	183	5	usually	usually	RB
cord-343791-0vykwml5	183	6	not	not	RB
cord-343791-0vykwml5	183	7	sufficiently	sufficiently	RB
cord-343791-0vykwml5	183	8	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	183	9	and	and	CC
cord-343791-0vykwml5	183	10	require	require	VBP
cord-343791-0vykwml5	183	11	adjuvants	adjuvant	NNS
cord-343791-0vykwml5	183	12	,	,	,
cord-343791-0vykwml5	183	13	the	the	DT
cord-343791-0vykwml5	183	14	Burkhard	Burkhard	NNP
cord-343791-0vykwml5	183	15	group	group	NN
cord-343791-0vykwml5	183	16	has	have	VBZ
cord-343791-0vykwml5	183	17	developed	develop	VBN
cord-343791-0vykwml5	183	18	a	a	DT
cord-343791-0vykwml5	183	19	self	self	NN
cord-343791-0vykwml5	183	20	-	-	HYPH
cord-343791-0vykwml5	183	21	assembling	assemble	VBG
cord-343791-0vykwml5	183	22	protein	protein	NN
cord-343791-0vykwml5	183	23	nanoparticle	nanoparticle	NN
cord-343791-0vykwml5	183	24	platform	platform	NN
cord-343791-0vykwml5	183	25	that	that	WDT
cord-343791-0vykwml5	183	26	displays	display	VBZ
cord-343791-0vykwml5	183	27	both	both	DT
cord-343791-0vykwml5	183	28	B	B	NNP
cord-343791-0vykwml5	183	29	and	and	CC
cord-343791-0vykwml5	183	30	T	T	NNP
cord-343791-0vykwml5	183	31	cell	cell	NN
cord-343791-0vykwml5	183	32	epitopes	epitope	NNS
cord-343791-0vykwml5	183	33	to	to	TO
cord-343791-0vykwml5	183	34	produce	produce	VB
cord-343791-0vykwml5	183	35	a	a	DT
cord-343791-0vykwml5	183	36	vaccine	vaccine	NN
cord-343791-0vykwml5	183	37	with	with	IN
cord-343791-0vykwml5	183	38	self	self	NN
cord-343791-0vykwml5	183	39	-	-	HYPH
cord-343791-0vykwml5	183	40	adjuvanting	adjuvante	VBG
cord-343791-0vykwml5	183	41	qualities	quality	NNS
cord-343791-0vykwml5	183	42	.	.	.
cord-343791-0vykwml5	184	1	[	[	-LRB-
cord-343791-0vykwml5	184	2	49	49	CD
cord-343791-0vykwml5	184	3	]	]	-RRB-
cord-343791-0vykwml5	185	1	This	this	DT
cord-343791-0vykwml5	185	2	platform	platform	NN
cord-343791-0vykwml5	185	3	is	be	VBZ
cord-343791-0vykwml5	185	4	currently	currently	RB
cord-343791-0vykwml5	185	5	under	under	IN
cord-343791-0vykwml5	185	6	development	development	NN
cord-343791-0vykwml5	185	7	to	to	TO
cord-343791-0vykwml5	185	8	improve	improve	VB
cord-343791-0vykwml5	185	9	a	a	DT
cord-343791-0vykwml5	185	10	malaria	malaria	NN
cord-343791-0vykwml5	185	11	vaccine	vaccine	NN
cord-343791-0vykwml5	185	12	,	,	,
cord-343791-0vykwml5	185	13	"	"	``
cord-343791-0vykwml5	185	14	RTS	RTS	NNP
cord-343791-0vykwml5	185	15	'S	'S	NNP
cord-343791-0vykwml5	185	16	"	"	''
cord-343791-0vykwml5	186	1	that	that	DT
cord-343791-0vykwml5	186	2	is	be	VBZ
cord-343791-0vykwml5	186	3	based	base	VBN
cord-343791-0vykwml5	186	4	on	on	IN
cord-343791-0vykwml5	186	5	the	the	DT
cord-343791-0vykwml5	186	6	circumsporozoite	circumsporozoite	JJ
cord-343791-0vykwml5	186	7	protein	protein	NN
cord-343791-0vykwml5	186	8	of	of	IN
cord-343791-0vykwml5	186	9	Plasmodium	Plasmodium	NNP
cord-343791-0vykwml5	186	10	falciparum	falciparum	NN
cord-343791-0vykwml5	186	11	.	.	.
cord-343791-0vykwml5	187	1	[	[	-LRB-
cord-343791-0vykwml5	187	2	50	50	CD
cord-343791-0vykwml5	187	3	]	]	-RRB-
cord-343791-0vykwml5	188	1	The	the	DT
cord-343791-0vykwml5	188	2	self	self	NN
cord-343791-0vykwml5	188	3	-	-	HYPH
cord-343791-0vykwml5	188	4	assembled	assemble	VBN
cord-343791-0vykwml5	188	5	protein	protein	NN
cord-343791-0vykwml5	188	6	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	188	7	are	be	VBP
cord-343791-0vykwml5	188	8	able	able	JJ
cord-343791-0vykwml5	188	9	to	to	TO
cord-343791-0vykwml5	188	10	stimulate	stimulate	VB
cord-343791-0vykwml5	188	11	high	high	JJ
cord-343791-0vykwml5	188	12	titer	titer	NN
cord-343791-0vykwml5	188	13	,	,	,
cord-343791-0vykwml5	188	14	high	high	JJ
cord-343791-0vykwml5	188	15	avidity	avidity	NN
cord-343791-0vykwml5	188	16	antibodies	antibody	NNS
cord-343791-0vykwml5	188	17	and	and	CC
cord-343791-0vykwml5	188	18	present	present	JJ
cord-343791-0vykwml5	188	19	CD8	CD8	NNP
cord-343791-0vykwml5	188	20	+	+	CC
cord-343791-0vykwml5	188	21	T	t	NN
cord-343791-0vykwml5	188	22	-	-	HYPH
cord-343791-0vykwml5	188	23	cell	cell	NN
cord-343791-0vykwml5	188	24	eptiopes	eptiope	NNS
cord-343791-0vykwml5	188	25	to	to	TO
cord-343791-0vykwml5	188	26	stimulate	stimulate	VB
cord-343791-0vykwml5	188	27	IL-2	IL-2	NNP
cord-343791-0vykwml5	188	28	and	and	CC
cord-343791-0vykwml5	188	29	IFN	IFN	NNP
cord-343791-0vykwml5	188	30	-	-	HYPH
cord-343791-0vykwml5	188	31	γ	γ	NNP
cord-343791-0vykwml5	188	32	producing	produce	VBG
cord-343791-0vykwml5	188	33	longterm	longterm	JJ
cord-343791-0vykwml5	188	34	memory	memory	NN
cord-343791-0vykwml5	188	35	T	T	NNP
cord-343791-0vykwml5	188	36	-	-	HYPH
cord-343791-0vykwml5	188	37	cells	cell	NNS
cord-343791-0vykwml5	188	38	in	in	IN
cord-343791-0vykwml5	188	39	mouse	mouse	NN
cord-343791-0vykwml5	188	40	models	model	NNS
cord-343791-0vykwml5	188	41	.	.	.
cord-343791-0vykwml5	189	1	The	the	DT
cord-343791-0vykwml5	189	2	vaccine	vaccine	NN
cord-343791-0vykwml5	189	3	candidate	candidate	NN
cord-343791-0vykwml5	189	4	FMP014	FMP014	NNS
cord-343791-0vykwml5	189	5	,	,	,
cord-343791-0vykwml5	189	6	based	base	VBN
cord-343791-0vykwml5	189	7	on	on	IN
cord-343791-0vykwml5	189	8	this	this	DT
cord-343791-0vykwml5	189	9	platform	platform	NN
cord-343791-0vykwml5	189	10	,	,	,
cord-343791-0vykwml5	189	11	is	be	VBZ
cord-343791-0vykwml5	189	12	currently	currently	RB
cord-343791-0vykwml5	189	13	undergoing	undergo	VBG
cord-343791-0vykwml5	189	14	phase	phase	NN
cord-343791-0vykwml5	189	15	1	1	CD
cord-343791-0vykwml5	189	16	clinical	clinical	JJ
cord-343791-0vykwml5	189	17	trials	trial	NNS
cord-343791-0vykwml5	189	18	.	.	.
cord-343791-0vykwml5	190	1	A	a	DT
cord-343791-0vykwml5	190	2	principal	principal	JJ
cord-343791-0vykwml5	190	3	advantage	advantage	NN
cord-343791-0vykwml5	190	4	of	of	IN
cord-343791-0vykwml5	190	5	designed	design	VBN
cord-343791-0vykwml5	190	6	protein	protein	NN
cord-343791-0vykwml5	190	7	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	190	8	is	be	VBZ
cord-343791-0vykwml5	190	9	their	-PRON-	PRP$
cord-343791-0vykwml5	190	10	chemical	chemical	NN
cord-343791-0vykwml5	190	11	definition	definition	NN
cord-343791-0vykwml5	190	12	.	.	.
cord-343791-0vykwml5	191	1	The	the	DT
cord-343791-0vykwml5	191	2	ability	ability	NN
cord-343791-0vykwml5	191	3	to	to	TO
cord-343791-0vykwml5	191	4	use	use	VB
cord-343791-0vykwml5	191	5	computational	computational	JJ
cord-343791-0vykwml5	191	6	methods	method	NNS
cord-343791-0vykwml5	191	7	to	to	TO
cord-343791-0vykwml5	191	8	design	design	VB
cord-343791-0vykwml5	191	9	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	191	10	of	of	IN
cord-343791-0vykwml5	191	11	different	different	JJ
cord-343791-0vykwml5	191	12	geometries	geometry	NNS
cord-343791-0vykwml5	191	13	and	and	CC
cord-343791-0vykwml5	191	14	sizes	size	NNS
cord-343791-0vykwml5	191	15	opens	open	VBZ
cord-343791-0vykwml5	191	16	the	the	DT
cord-343791-0vykwml5	191	17	door	door	NN
cord-343791-0vykwml5	191	18	to	to	IN
cord-343791-0vykwml5	191	19	applications	application	NNS
cord-343791-0vykwml5	191	20	such	such	JJ
cord-343791-0vykwml5	191	21	as	as	IN
cord-343791-0vykwml5	191	22	drug	drug	NN
cord-343791-0vykwml5	191	23	delivery	delivery	NN
cord-343791-0vykwml5	191	24	,	,	,
cord-343791-0vykwml5	191	25	in	in	IN
cord-343791-0vykwml5	191	26	which	which	WDT
cord-343791-0vykwml5	191	27	the	the	DT
cord-343791-0vykwml5	191	28	shape	shape	NN
cord-343791-0vykwml5	191	29	and	and	CC
cord-343791-0vykwml5	191	30	size	size	NN
cord-343791-0vykwml5	191	31	of	of	IN
cord-343791-0vykwml5	191	32	the	the	DT
cord-343791-0vykwml5	191	33	delivery	delivery	NN
cord-343791-0vykwml5	191	34	vehicle	vehicle	NN
cord-343791-0vykwml5	191	35	are	be	VBP
cord-343791-0vykwml5	191	36	crucial	crucial	JJ
cord-343791-0vykwml5	191	37	.	.	.
cord-343791-0vykwml5	192	1	However	however	RB
cord-343791-0vykwml5	192	2	,	,	,
cord-343791-0vykwml5	192	3	the	the	DT
cord-343791-0vykwml5	192	4	manufacturability	manufacturability	NN
cord-343791-0vykwml5	192	5	of	of	IN
cord-343791-0vykwml5	192	6	these	these	DT
cord-343791-0vykwml5	192	7	platforms	platform	NNS
cord-343791-0vykwml5	192	8	,	,	,
cord-343791-0vykwml5	192	9	similar	similar	JJ
cord-343791-0vykwml5	192	10	to	to	IN
cord-343791-0vykwml5	192	11	VLPs	vlp	NNS
cord-343791-0vykwml5	192	12	,	,	,
cord-343791-0vykwml5	192	13	is	be	VBZ
cord-343791-0vykwml5	192	14	a	a	DT
cord-343791-0vykwml5	192	15	challenge	challenge	NN
cord-343791-0vykwml5	192	16	due	due	IN
cord-343791-0vykwml5	192	17	to	to	IN
cord-343791-0vykwml5	192	18	their	-PRON-	PRP$
cord-343791-0vykwml5	192	19	multi	multi	JJ
cord-343791-0vykwml5	192	20	-	-	JJ
cord-343791-0vykwml5	192	21	subunit	subunit	JJ
cord-343791-0vykwml5	192	22	nature	nature	NN
cord-343791-0vykwml5	192	23	and	and	CC
cord-343791-0vykwml5	192	24	the	the	DT
cord-343791-0vykwml5	192	25	need	need	NN
cord-343791-0vykwml5	192	26	to	to	TO
cord-343791-0vykwml5	192	27	be	be	VB
cord-343791-0vykwml5	192	28	recombinantly	recombinantly	RB
cord-343791-0vykwml5	192	29	expressed	express	VBN
cord-343791-0vykwml5	192	30	.	.	.
cord-343791-0vykwml5	193	1	Micellar	micellar	JJ
cord-343791-0vykwml5	193	2	nanocarriers	nanocarrier	NNS
cord-343791-0vykwml5	193	3	composed	compose	VBN
cord-343791-0vykwml5	193	4	of	of	IN
cord-343791-0vykwml5	193	5	amphiphilic	amphiphilic	JJ
cord-343791-0vykwml5	193	6	molecules	molecule	NNS
cord-343791-0vykwml5	193	7	have	have	VBP
cord-343791-0vykwml5	193	8	had	have	VBN
cord-343791-0vykwml5	193	9	particular	particular	JJ
cord-343791-0vykwml5	193	10	success	success	NN
cord-343791-0vykwml5	193	11	in	in	IN
cord-343791-0vykwml5	193	12	the	the	DT
cord-343791-0vykwml5	193	13	pharmaceutical	pharmaceutical	JJ
cord-343791-0vykwml5	193	14	realm	realm	NN
cord-343791-0vykwml5	193	15	as	as	IN
cord-343791-0vykwml5	193	16	a	a	DT
cord-343791-0vykwml5	193	17	tool	tool	NN
cord-343791-0vykwml5	193	18	to	to	TO
cord-343791-0vykwml5	193	19	increase	increase	VB
cord-343791-0vykwml5	193	20	bioavailability	bioavailability	NN
cord-343791-0vykwml5	193	21	,	,	,
cord-343791-0vykwml5	193	22	retention	retention	NN
cord-343791-0vykwml5	193	23	,	,	,
cord-343791-0vykwml5	193	24	and	and	CC
cord-343791-0vykwml5	193	25	solubility	solubility	NN
cord-343791-0vykwml5	193	26	of	of	IN
cord-343791-0vykwml5	193	27	various	various	JJ
cord-343791-0vykwml5	193	28	drugs	drug	NNS
cord-343791-0vykwml5	193	29	.	.	.
cord-343791-0vykwml5	194	1	[	[	-LRB-
cord-343791-0vykwml5	194	2	51	51	CD
cord-343791-0vykwml5	194	3	]	]	-RRB-
cord-343791-0vykwml5	195	1	However	however	RB
cord-343791-0vykwml5	195	2	,	,	,
cord-343791-0vykwml5	195	3	in	in	IN
cord-343791-0vykwml5	195	4	this	this	DT
cord-343791-0vykwml5	195	5	review	review	NN
cord-343791-0vykwml5	195	6	,	,	,
cord-343791-0vykwml5	195	7	we	-PRON-	PRP
cord-343791-0vykwml5	195	8	shall	shall	MD
cord-343791-0vykwml5	195	9	be	be	VB
cord-343791-0vykwml5	195	10	focusing	focus	VBG
cord-343791-0vykwml5	195	11	on	on	IN
cord-343791-0vykwml5	195	12	peptide	peptide	JJ
cord-343791-0vykwml5	195	13	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	195	14	(	(	-LRB-
cord-343791-0vykwml5	195	15	PAs	pas	NN
cord-343791-0vykwml5	195	16	)	)	-RRB-
cord-343791-0vykwml5	195	17	as	as	IN
cord-343791-0vykwml5	195	18	they	-PRON-	PRP
cord-343791-0vykwml5	195	19	relate	relate	VBP
cord-343791-0vykwml5	195	20	to	to	IN
cord-343791-0vykwml5	195	21	our	-PRON-	PRP$
cord-343791-0vykwml5	195	22	theme	theme	NN
cord-343791-0vykwml5	195	23	of	of	IN
cord-343791-0vykwml5	195	24	the	the	DT
cord-343791-0vykwml5	195	25	clinical	clinical	JJ
cord-343791-0vykwml5	195	26	translation	translation	NN
cord-343791-0vykwml5	195	27	of	of	IN
cord-343791-0vykwml5	195	28	peptide	peptide	NN
cord-343791-0vykwml5	195	29	-	-	HYPH
cord-343791-0vykwml5	195	30	based	base	VBN
cord-343791-0vykwml5	195	31	materials	material	NNS
cord-343791-0vykwml5	195	32	.	.	.
cord-343791-0vykwml5	196	1	Such	such	JJ
cord-343791-0vykwml5	196	2	structures	structure	NNS
cord-343791-0vykwml5	196	3	self	self	NN
cord-343791-0vykwml5	196	4	-	-	HYPH
cord-343791-0vykwml5	196	5	assemble	assemble	VBP
cord-343791-0vykwml5	196	6	from	from	IN
cord-343791-0vykwml5	196	7	molecules	molecule	NNS
cord-343791-0vykwml5	196	8	composed	compose	VBN
cord-343791-0vykwml5	196	9	of	of	IN
cord-343791-0vykwml5	196	10	a	a	DT
cord-343791-0vykwml5	196	11	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	196	12	domain	domain	NN
cord-343791-0vykwml5	196	13	,	,	,
cord-343791-0vykwml5	196	14	usually	usually	RB
cord-343791-0vykwml5	196	15	an	an	DT
cord-343791-0vykwml5	196	16	alkyl	alkyl	NN
cord-343791-0vykwml5	196	17	chain	chain	NN
cord-343791-0vykwml5	196	18	,	,	,
cord-343791-0vykwml5	196	19	and	and	CC
cord-343791-0vykwml5	196	20	a	a	DT
cord-343791-0vykwml5	196	21	hydrophilic	hydrophilic	JJ
cord-343791-0vykwml5	196	22	peptide	peptide	NN
cord-343791-0vykwml5	196	23	domain	domain	NN
cord-343791-0vykwml5	196	24	.	.	.
cord-343791-0vykwml5	197	1	[	[	-LRB-
cord-343791-0vykwml5	197	2	4	4	CD
cord-343791-0vykwml5	197	3	,	,	,
cord-343791-0vykwml5	197	4	52	52	CD
cord-343791-0vykwml5	197	5	]	]	-RRB-
cord-343791-0vykwml5	197	6	PA	PA	NNP
cord-343791-0vykwml5	197	7	assembly	assembly	NN
cord-343791-0vykwml5	197	8	is	be	VBZ
cord-343791-0vykwml5	197	9	driven	drive	VBN
cord-343791-0vykwml5	197	10	by	by	IN
cord-343791-0vykwml5	197	11	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	197	12	-	-	HYPH
cord-343791-0vykwml5	197	13	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	197	14	interactions	interaction	NNS
cord-343791-0vykwml5	197	15	in	in	IN
cord-343791-0vykwml5	197	16	water	water	NN
cord-343791-0vykwml5	197	17	,	,	,
cord-343791-0vykwml5	197	18	and	and	CC
cord-343791-0vykwml5	197	19	bioactivity	bioactivity	NN
cord-343791-0vykwml5	197	20	is	be	VBZ
cord-343791-0vykwml5	197	21	programmed	program	VBN
cord-343791-0vykwml5	197	22	into	into	IN
cord-343791-0vykwml5	197	23	the	the	DT
cord-343791-0vykwml5	197	24	hydrophilic	hydrophilic	JJ
cord-343791-0vykwml5	197	25	peptide	peptide	JJ
cord-343791-0vykwml5	197	26	head	head	NN
cord-343791-0vykwml5	197	27	groups	group	NNS
cord-343791-0vykwml5	197	28	(	(	-LRB-
cord-343791-0vykwml5	197	29	see	see	VB
cord-343791-0vykwml5	197	30	Figure	figure	NN
cord-343791-0vykwml5	197	31	1C	1c	NN
cord-343791-0vykwml5	197	32	)	)	-RRB-
cord-343791-0vykwml5	197	33	.	.	.
cord-343791-0vykwml5	198	1	For	for	IN
cord-343791-0vykwml5	198	2	a	a	DT
cord-343791-0vykwml5	198	3	comprehensive	comprehensive	JJ
cord-343791-0vykwml5	198	4	review	review	NN
cord-343791-0vykwml5	198	5	on	on	IN
cord-343791-0vykwml5	198	6	PAs	pas	NN
cord-343791-0vykwml5	198	7	used	use	VBN
cord-343791-0vykwml5	198	8	in	in	IN
cord-343791-0vykwml5	198	9	biomedical	biomedical	JJ
cord-343791-0vykwml5	198	10	applications	application	NNS
cord-343791-0vykwml5	198	11	,	,	,
cord-343791-0vykwml5	198	12	the	the	DT
cord-343791-0vykwml5	198	13	reader	reader	NN
cord-343791-0vykwml5	198	14	is	be	VBZ
cord-343791-0vykwml5	198	15	directed	direct	VBN
cord-343791-0vykwml5	198	16	to	to	IN
cord-343791-0vykwml5	198	17	Acar	Acar	NNP
cord-343791-0vykwml5	198	18	et	et	NNP
cord-343791-0vykwml5	198	19	al	al	NNP
cord-343791-0vykwml5	198	20	.	.	.
cord-343791-0vykwml5	199	1	[	[	-LRB-
cord-343791-0vykwml5	199	2	6	6	CD
cord-343791-0vykwml5	199	3	]	]	-RRB-
cord-343791-0vykwml5	199	4	Targeting	target	VBG
cord-343791-0vykwml5	199	5	,	,	,
cord-343791-0vykwml5	199	6	diagnostic	diagnostic	JJ
cord-343791-0vykwml5	199	7	,	,	,
cord-343791-0vykwml5	199	8	and	and	CC
cord-343791-0vykwml5	199	9	theranostic	theranostic	JJ
cord-343791-0vykwml5	199	10	platforms	platform	NNS
cord-343791-0vykwml5	199	11	have	have	VBP
cord-343791-0vykwml5	199	12	been	be	VBN
cord-343791-0vykwml5	199	13	derived	derive	VBN
cord-343791-0vykwml5	199	14	from	from	IN
cord-343791-0vykwml5	199	15	peptide	peptide	NN
cord-343791-0vykwml5	199	16	amphiphile	amphiphile	NNP
cord-343791-0vykwml5	199	17	micelles	micelle	NNS
cord-343791-0vykwml5	199	18	(	(	-LRB-
cord-343791-0vykwml5	199	19	PAMs	pam	NNS
cord-343791-0vykwml5	199	20	)	)	-RRB-
cord-343791-0vykwml5	199	21	.	.	.
cord-343791-0vykwml5	200	1	To	to	TO
cord-343791-0vykwml5	200	2	increase	increase	VB
cord-343791-0vykwml5	200	3	the	the	DT
cord-343791-0vykwml5	200	4	size	size	NN
cord-343791-0vykwml5	200	5	of	of	IN
cord-343791-0vykwml5	200	6	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	200	7	head	head	NN
cord-343791-0vykwml5	200	8	groups	group	NNS
cord-343791-0vykwml5	200	9	and	and	CC
cord-343791-0vykwml5	200	10	push	push	VB
cord-343791-0vykwml5	200	11	systems	system	NNS
cord-343791-0vykwml5	200	12	toward	toward	IN
cord-343791-0vykwml5	200	13	a	a	DT
cord-343791-0vykwml5	200	14	micellar	micellar	JJ
cord-343791-0vykwml5	200	15	packing	packing	NN
cord-343791-0vykwml5	200	16	morphology	morphology	NN
cord-343791-0vykwml5	200	17	,	,	,
cord-343791-0vykwml5	200	18	the	the	DT
cord-343791-0vykwml5	200	19	micelles	micelle	NNS
cord-343791-0vykwml5	200	20	consist	consist	VBP
cord-343791-0vykwml5	200	21	of	of	IN
cord-343791-0vykwml5	200	22	a	a	DT
cord-343791-0vykwml5	200	23	biologically	biologically	RB
cord-343791-0vykwml5	200	24	active	active	JJ
cord-343791-0vykwml5	200	25	peptide	peptide	NN
cord-343791-0vykwml5	200	26	attached	attach	VBN
cord-343791-0vykwml5	200	27	to	to	IN
cord-343791-0vykwml5	200	28	a	a	DT
cord-343791-0vykwml5	200	29	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	200	30	alkyl	alkyl	NN
cord-343791-0vykwml5	200	31	tail	tail	NN
cord-343791-0vykwml5	200	32	via	via	IN
cord-343791-0vykwml5	200	33	a	a	DT
cord-343791-0vykwml5	200	34	bulky	bulky	JJ
cord-343791-0vykwml5	200	35	polyethylene	polyethylene	NN
cord-343791-0vykwml5	200	36	glycol	glycol	NN
cord-343791-0vykwml5	200	37	(	(	-LRB-
cord-343791-0vykwml5	200	38	PEG	peg	NN
cord-343791-0vykwml5	200	39	)	)	-RRB-
cord-343791-0vykwml5	200	40	spacer	spacer	NN
cord-343791-0vykwml5	200	41	.	.	.
cord-343791-0vykwml5	201	1	The	the	DT
cord-343791-0vykwml5	201	2	PEG	PEG	NNP
cord-343791-0vykwml5	201	3	spacer	spacer	NN
cord-343791-0vykwml5	201	4	allows	allow	VBZ
cord-343791-0vykwml5	201	5	for	for	IN
cord-343791-0vykwml5	201	6	enhanced	enhanced	JJ
cord-343791-0vykwml5	201	7	blood	blood	NN
cord-343791-0vykwml5	201	8	circulation	circulation	NN
cord-343791-0vykwml5	201	9	times	time	NNS
cord-343791-0vykwml5	201	10	while	while	IN
cord-343791-0vykwml5	201	11	retaining	retain	VBG
cord-343791-0vykwml5	201	12	the	the	DT
cord-343791-0vykwml5	201	13	packing	packing	NN
cord-343791-0vykwml5	201	14	parameters	parameter	NNS
cord-343791-0vykwml5	201	15	necessary	necessary	JJ
cord-343791-0vykwml5	201	16	for	for	IN
cord-343791-0vykwml5	201	17	micelle	micelle	NN
cord-343791-0vykwml5	201	18	formation	formation	NN
cord-343791-0vykwml5	201	19	.	.	.
cord-343791-0vykwml5	202	1	[	[	-LRB-
cord-343791-0vykwml5	202	2	6	6	CD
cord-343791-0vykwml5	202	3	]	]	-RRB-
cord-343791-0vykwml5	203	1	These	these	DT
cord-343791-0vykwml5	203	2	molecules	molecule	NNS
cord-343791-0vykwml5	203	3	are	be	VBP
cord-343791-0vykwml5	203	4	shown	show	VBN
cord-343791-0vykwml5	203	5	to	to	TO
cord-343791-0vykwml5	203	6	circulate	circulate	VB
cord-343791-0vykwml5	203	7	through	through	IN
cord-343791-0vykwml5	203	8	the	the	DT
cord-343791-0vykwml5	203	9	blood	blood	NN
cord-343791-0vykwml5	203	10	stream	stream	NN
cord-343791-0vykwml5	203	11	without	without	IN
cord-343791-0vykwml5	203	12	causing	cause	VBG
cord-343791-0vykwml5	203	13	blockage	blockage	NN
cord-343791-0vykwml5	203	14	,	,	,
cord-343791-0vykwml5	203	15	and	and	CC
cord-343791-0vykwml5	203	16	are	be	VBP
cord-343791-0vykwml5	203	17	cleared	clear	VBN
cord-343791-0vykwml5	203	18	via	via	IN
cord-343791-0vykwml5	203	19	the	the	DT
cord-343791-0vykwml5	203	20	reticulo	reticulo	NN
cord-343791-0vykwml5	203	21	-	-	HYPH
cord-343791-0vykwml5	203	22	endothelial	endothelial	JJ
cord-343791-0vykwml5	203	23	system	system	NN
cord-343791-0vykwml5	203	24	and	and	CC
cord-343791-0vykwml5	203	25	renal	renal	JJ
cord-343791-0vykwml5	203	26	system	system	NN
cord-343791-0vykwml5	203	27	with	with	IN
cord-343791-0vykwml5	203	28	90	90	CD
cord-343791-0vykwml5	203	29	%	%	NN
cord-343791-0vykwml5	203	30	clearance	clearance	NN
cord-343791-0vykwml5	203	31	and	and	CC
cord-343791-0vykwml5	203	32	no	no	DT
cord-343791-0vykwml5	203	33	toxicity	toxicity	NN
cord-343791-0vykwml5	203	34	after	after	IN
cord-343791-0vykwml5	203	35	7	7	CD
cord-343791-0vykwml5	203	36	d.	d.	NN
cord-343791-0vykwml5	204	1	[	[	-LRB-
cord-343791-0vykwml5	204	2	53	53	CD
cord-343791-0vykwml5	204	3	]	]	-RRB-
cord-343791-0vykwml5	204	4	PAMs	pam	NNS
cord-343791-0vykwml5	204	5	are	be	VBP
cord-343791-0vykwml5	204	6	currently	currently	RB
cord-343791-0vykwml5	204	7	in	in	IN
cord-343791-0vykwml5	204	8	preclinical	preclinical	JJ
cord-343791-0vykwml5	204	9	development	development	NN
cord-343791-0vykwml5	204	10	for	for	IN
cord-343791-0vykwml5	204	11	both	both	DT
cord-343791-0vykwml5	204	12	cancer	cancer	NN
cord-343791-0vykwml5	204	13	and	and	CC
cord-343791-0vykwml5	204	14	atherosclerosis	atherosclerosis	NN
cord-343791-0vykwml5	204	15	diagnostic	diagnostic	JJ
cord-343791-0vykwml5	204	16	applications	application	NNS
cord-343791-0vykwml5	204	17	.	.	.
cord-343791-0vykwml5	205	1	For	for	IN
cord-343791-0vykwml5	205	2	cancer	cancer	NN
cord-343791-0vykwml5	205	3	applications	application	NNS
cord-343791-0vykwml5	205	4	,	,	,
cord-343791-0vykwml5	205	5	fluorescently	fluorescently	RB
cord-343791-0vykwml5	205	6	-	-	HYPH
cord-343791-0vykwml5	205	7	labeled	label	VBN
cord-343791-0vykwml5	205	8	PAs	pas	NN
cord-343791-0vykwml5	205	9	with	with	IN
cord-343791-0vykwml5	205	10	the	the	DT
cord-343791-0vykwml5	205	11	fibrin	fibrin	NN
cord-343791-0vykwml5	205	12	-	-	HYPH
cord-343791-0vykwml5	205	13	binding	bind	VBG
cord-343791-0vykwml5	205	14	peptide	peptide	NN
cord-343791-0vykwml5	205	15	CREKA	CREKA	NNP
cord-343791-0vykwml5	205	16	were	be	VBD
cord-343791-0vykwml5	205	17	used	use	VBN
cord-343791-0vykwml5	205	18	to	to	TO
cord-343791-0vykwml5	205	19	target	target	VB
cord-343791-0vykwml5	205	20	glioblastoma	glioblastoma	NN
cord-343791-0vykwml5	205	21	cells	cell	NNS
cord-343791-0vykwml5	205	22	.	.	.
cord-343791-0vykwml5	206	1	Upon	upon	IN
cord-343791-0vykwml5	206	2	intravenous	intravenous	JJ
cord-343791-0vykwml5	206	3	administration	administration	NN
cord-343791-0vykwml5	206	4	to	to	IN
cord-343791-0vykwml5	206	5	GL261	gl261	NN
cord-343791-0vykwml5	206	6	glioma	glioma	NN
cord-343791-0vykwml5	206	7	-	-	HYPH
cord-343791-0vykwml5	206	8	bearing	bear	VBG
cord-343791-0vykwml5	206	9	mice	mouse	NNS
cord-343791-0vykwml5	206	10	,	,	,
cord-343791-0vykwml5	206	11	nontargeting	nontargeting	NN
cord-343791-0vykwml5	206	12	micelles	micelle	NNS
cord-343791-0vykwml5	206	13	passively	passively	RB
cord-343791-0vykwml5	206	14	accumulated	accumulate	VBN
cord-343791-0vykwml5	206	15	at	at	IN
cord-343791-0vykwml5	206	16	the	the	DT
cord-343791-0vykwml5	206	17	fibrin	fibrin	NN
cord-343791-0vykwml5	206	18	deposits	deposit	NNS
cord-343791-0vykwml5	206	19	characteristic	characteristic	JJ
cord-343791-0vykwml5	206	20	of	of	IN
cord-343791-0vykwml5	206	21	tumor	tumor	NN
cord-343791-0vykwml5	206	22	vasculature	vasculature	NN
cord-343791-0vykwml5	206	23	.	.	.
cord-343791-0vykwml5	207	1	These	these	DT
cord-343791-0vykwml5	207	2	micelles	micelle	NNS
cord-343791-0vykwml5	207	3	displayed	display	VBD
cord-343791-0vykwml5	207	4	enhanced	enhanced	JJ
cord-343791-0vykwml5	207	5	tumor	tumor	NN
cord-343791-0vykwml5	207	6	homing	homing	NN
cord-343791-0vykwml5	207	7	as	as	RB
cord-343791-0vykwml5	207	8	early	early	RB
cord-343791-0vykwml5	207	9	as	as	IN
cord-343791-0vykwml5	207	10	1	1	CD
cord-343791-0vykwml5	207	11	h	h	NN
cord-343791-0vykwml5	207	12	after	after	IN
cord-343791-0vykwml5	207	13	administration	administration	NN
cord-343791-0vykwml5	207	14	without	without	IN
cord-343791-0vykwml5	207	15	inducing	induce	VBG
cord-343791-0vykwml5	207	16	cytotoxicity	cytotoxicity	NN
cord-343791-0vykwml5	207	17	or	or	CC
cord-343791-0vykwml5	207	18	tissue	tissue	NN
cord-343791-0vykwml5	207	19	damage	damage	NN
cord-343791-0vykwml5	207	20	.	.	.
cord-343791-0vykwml5	208	1	[	[	-LRB-
cord-343791-0vykwml5	208	2	54	54	CD
cord-343791-0vykwml5	208	3	]	]	-RRB-
cord-343791-0vykwml5	209	1	Toward	toward	IN
cord-343791-0vykwml5	209	2	a	a	DT
cord-343791-0vykwml5	209	3	therapy	therapy	NN
cord-343791-0vykwml5	209	4	for	for	IN
cord-343791-0vykwml5	209	5	atherosclerosis	atherosclerosis	NN
cord-343791-0vykwml5	209	6	,	,	,
cord-343791-0vykwml5	209	7	the	the	DT
cord-343791-0vykwml5	209	8	CREKA	CREKA	NNP
cord-343791-0vykwml5	209	9	targeting	target	VBG
cord-343791-0vykwml5	209	10	peptide	peptide	NN
cord-343791-0vykwml5	209	11	,	,	,
cord-343791-0vykwml5	209	12	an	an	DT
cord-343791-0vykwml5	209	13	antithrombin	antithrombin	NN
cord-343791-0vykwml5	209	14	peptide	peptide	NN
cord-343791-0vykwml5	209	15	called	call	VBN
cord-343791-0vykwml5	209	16	hirulog	hirulog	NN
cord-343791-0vykwml5	209	17	,	,	,
cord-343791-0vykwml5	209	18	and	and	CC
cord-343791-0vykwml5	209	19	fluorescence	fluorescence	NN
cord-343791-0vykwml5	209	20	molecules	molecule	NNS
cord-343791-0vykwml5	209	21	were	be	VBD
cord-343791-0vykwml5	209	22	assembled	assemble	VBN
cord-343791-0vykwml5	209	23	into	into	IN
cord-343791-0vykwml5	209	24	theranostic	theranostic	JJ
cord-343791-0vykwml5	209	25	micelles	micelle	NNS
cord-343791-0vykwml5	209	26	.	.	.
cord-343791-0vykwml5	210	1	[	[	-LRB-
cord-343791-0vykwml5	210	2	55	55	CD
cord-343791-0vykwml5	210	3	]	]	-RRB-
cord-343791-0vykwml5	211	1	This	this	DT
cord-343791-0vykwml5	211	2	fibrin	fibrin	NN
cord-343791-0vykwml5	211	3	-	-	HYPH
cord-343791-0vykwml5	211	4	targeting	target	VBG
cord-343791-0vykwml5	211	5	micelle	micelle	NN
cord-343791-0vykwml5	211	6	could	could	MD
cord-343791-0vykwml5	211	7	also	also	RB
cord-343791-0vykwml5	211	8	be	be	VB
cord-343791-0vykwml5	211	9	functionalized	functionalize	VBN
cord-343791-0vykwml5	211	10	by	by	IN
cord-343791-0vykwml5	211	11	the	the	DT
cord-343791-0vykwml5	211	12	addition	addition	NN
cord-343791-0vykwml5	211	13	of	of	IN
cord-343791-0vykwml5	211	14	the	the	DT
cord-343791-0vykwml5	211	15	gadolinium	gadolinium	NN
cord-343791-0vykwml5	211	16	chelator	chelator	NN
cord-343791-0vykwml5	211	17	diethylenetriaminepentaacetic	diethylenetriaminepentaacetic	NNP
cord-343791-0vykwml5	211	18	acid	acid	NNP
cord-343791-0vykwml5	211	19	,	,	,
cord-343791-0vykwml5	211	20	allowing	allow	VBG
cord-343791-0vykwml5	211	21	for	for	IN
cord-343791-0vykwml5	211	22	plaque	plaque	NN
cord-343791-0vykwml5	211	23	localization	localization	NN
cord-343791-0vykwml5	211	24	and	and	CC
cord-343791-0vykwml5	211	25	visualization	visualization	NN
cord-343791-0vykwml5	211	26	using	use	VBG
cord-343791-0vykwml5	211	27	T1-weighted	t1-weighte	VBN
cord-343791-0vykwml5	211	28	magnetic	magnetic	JJ
cord-343791-0vykwml5	211	29	resonance	resonance	NN
cord-343791-0vykwml5	211	30	imaging	imaging	NN
cord-343791-0vykwml5	211	31	(	(	-LRB-
cord-343791-0vykwml5	211	32	MRI	MRI	NNP
cord-343791-0vykwml5	211	33	)	)	-RRB-
cord-343791-0vykwml5	211	34	imaging	imaging	NN
cord-343791-0vykwml5	211	35	.	.	.
cord-343791-0vykwml5	212	1	[	[	-LRB-
cord-343791-0vykwml5	212	2	56	56	CD
cord-343791-0vykwml5	212	3	]	]	-RRB-
cord-343791-0vykwml5	213	1	Similar	similar	JJ
cord-343791-0vykwml5	213	2	PAMs	pam	NNS
cord-343791-0vykwml5	213	3	have	have	VBP
cord-343791-0vykwml5	213	4	been	be	VBN
cord-343791-0vykwml5	213	5	designed	design	VBN
cord-343791-0vykwml5	213	6	for	for	IN
cord-343791-0vykwml5	213	7	the	the	DT
cord-343791-0vykwml5	213	8	targeting	targeting	NN
cord-343791-0vykwml5	213	9	of	of	IN
cord-343791-0vykwml5	213	10	monocytes	monocyte	NNS
cord-343791-0vykwml5	213	11	as	as	IN
cord-343791-0vykwml5	213	12	a	a	DT
cord-343791-0vykwml5	213	13	strategy	strategy	NN
cord-343791-0vykwml5	213	14	to	to	TO
cord-343791-0vykwml5	213	15	diagnose	diagnose	VB
cord-343791-0vykwml5	213	16	atherosclerosis	atherosclerosis	NN
cord-343791-0vykwml5	213	17	via	via	IN
cord-343791-0vykwml5	213	18	the	the	DT
cord-343791-0vykwml5	213	19	areas	area	NNS
cord-343791-0vykwml5	213	20	of	of	IN
cord-343791-0vykwml5	213	21	heightened	heightened	JJ
cord-343791-0vykwml5	213	22	immunological	immunological	JJ
cord-343791-0vykwml5	213	23	activity	activity	NN
cord-343791-0vykwml5	213	24	characterized	characterize	VBN
cord-343791-0vykwml5	213	25	by	by	IN
cord-343791-0vykwml5	213	26	the	the	DT
cord-343791-0vykwml5	213	27	disease	disease	NN
cord-343791-0vykwml5	213	28	.	.	.
cord-343791-0vykwml5	214	1	[	[	-LRB-
cord-343791-0vykwml5	214	2	10	10	CD
cord-343791-0vykwml5	214	3	]	]	-RRB-
cord-343791-0vykwml5	214	4	Similarly	similarly	RB
cord-343791-0vykwml5	214	5	to	to	TO
cord-343791-0vykwml5	214	6	previously	previously	RB
cord-343791-0vykwml5	214	7	described	describe	VBN
cord-343791-0vykwml5	214	8	vaccine	vaccine	NN
cord-343791-0vykwml5	214	9	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	214	10	,	,	,
cord-343791-0vykwml5	214	11	PA	PA	NNP
cord-343791-0vykwml5	214	12	micelles	micelle	NNS
cord-343791-0vykwml5	214	13	are	be	VBP
cord-343791-0vykwml5	214	14	able	able	JJ
cord-343791-0vykwml5	214	15	to	to	TO
cord-343791-0vykwml5	214	16	elicit	elicit	VB
cord-343791-0vykwml5	214	17	either	either	CC
cord-343791-0vykwml5	214	18	humoral	humoral	JJ
cord-343791-0vykwml5	214	19	or	or	CC
cord-343791-0vykwml5	214	20	cell	cell	NN
cord-343791-0vykwml5	214	21	-	-	HYPH
cord-343791-0vykwml5	214	22	mediated	mediate	VBN
cord-343791-0vykwml5	214	23	immunity	immunity	NN
cord-343791-0vykwml5	214	24	without	without	IN
cord-343791-0vykwml5	214	25	additional	additional	JJ
cord-343791-0vykwml5	214	26	adjuvant	adjuvant	NN
cord-343791-0vykwml5	214	27	.	.	.
cord-343791-0vykwml5	215	1	An	an	DT
cord-343791-0vykwml5	215	2	antigen	antigen	NN
cord-343791-0vykwml5	215	3	is	be	VBZ
cord-343791-0vykwml5	215	4	simply	simply	RB
cord-343791-0vykwml5	215	5	conjugated	conjugate	VBN
cord-343791-0vykwml5	215	6	to	to	IN
cord-343791-0vykwml5	215	7	the	the	DT
cord-343791-0vykwml5	215	8	tail	tail	NN
cord-343791-0vykwml5	215	9	domain	domain	NN
cord-343791-0vykwml5	215	10	of	of	IN
cord-343791-0vykwml5	215	11	the	the	DT
cord-343791-0vykwml5	215	12	molecule	molecule	NN
cord-343791-0vykwml5	215	13	prior	prior	RB
cord-343791-0vykwml5	215	14	to	to	IN
cord-343791-0vykwml5	215	15	selfassembly	selfassembly	NNP
cord-343791-0vykwml5	215	16	.	.	.
cord-343791-0vykwml5	216	1	Black	Black	NNP
cord-343791-0vykwml5	216	2	et	et	NNP
cord-343791-0vykwml5	216	3	al	al	NNP
cord-343791-0vykwml5	216	4	.	.	NNP
cord-343791-0vykwml5	216	5	was	be	VBD
cord-343791-0vykwml5	216	6	able	able	JJ
cord-343791-0vykwml5	216	7	to	to	TO
cord-343791-0vykwml5	216	8	assemble	assemble	VB
cord-343791-0vykwml5	216	9	cylindrical	cylindrical	JJ
cord-343791-0vykwml5	216	10	micelles	micelle	NNS
cord-343791-0vykwml5	216	11	from	from	IN
cord-343791-0vykwml5	216	12	monomers	monomer	NNS
cord-343791-0vykwml5	216	13	consisting	consist	VBG
cord-343791-0vykwml5	216	14	of	of	IN
cord-343791-0vykwml5	216	15	a	a	DT
cord-343791-0vykwml5	216	16	dialkyl	dialkyl	NN
cord-343791-0vykwml5	216	17	tail	tail	NN
cord-343791-0vykwml5	216	18	conjugated	conjugate	VBN
cord-343791-0vykwml5	216	19	to	to	IN
cord-343791-0vykwml5	216	20	a	a	DT
cord-343791-0vykwml5	216	21	peptide	peptide	NN
cord-343791-0vykwml5	216	22	containing	contain	VBG
cord-343791-0vykwml5	216	23	the	the	DT
cord-343791-0vykwml5	216	24	known	know	VBN
cord-343791-0vykwml5	216	25	cytotoxic	cytotoxic	JJ
cord-343791-0vykwml5	216	26	T	t	NN
cord-343791-0vykwml5	216	27	-	-	HYPH
cord-343791-0vykwml5	216	28	cell	cell	NN
cord-343791-0vykwml5	216	29	epitope	epitope	NN
cord-343791-0vykwml5	216	30	from	from	IN
cord-343791-0vykwml5	216	31	the	the	DT
cord-343791-0vykwml5	216	32	model	model	NN
cord-343791-0vykwml5	216	33	tumor	tumor	NN
cord-343791-0vykwml5	216	34	antigen	antigen	NN
cord-343791-0vykwml5	216	35	ovalbumin	ovalbumin	NNP
cord-343791-0vykwml5	216	36	.	.	.
cord-343791-0vykwml5	217	1	[	[	-LRB-
cord-343791-0vykwml5	217	2	57	57	CD
cord-343791-0vykwml5	217	3	]	]	-RRB-
cord-343791-0vykwml5	218	1	These	these	DT
cord-343791-0vykwml5	218	2	diC	dic	JJ
cord-343791-0vykwml5	218	3	16	16	CD
cord-343791-0vykwml5	218	4	-OVA	-ova	SYM
cord-343791-0vykwml5	218	5	micelles	micelle	NNS
cord-343791-0vykwml5	218	6	were	be	VBD
cord-343791-0vykwml5	218	7	able	able	JJ
cord-343791-0vykwml5	218	8	to	to	TO
cord-343791-0vykwml5	218	9	stimulate	stimulate	VB
cord-343791-0vykwml5	218	10	OVA	ova	NN
cord-343791-0vykwml5	218	11	-	-	HYPH
cord-343791-0vykwml5	218	12	specific	specific	JJ
cord-343791-0vykwml5	218	13	T	t	NN
cord-343791-0vykwml5	218	14	-	-	HYPH
cord-343791-0vykwml5	218	15	cells	cell	NNS
cord-343791-0vykwml5	218	16	,	,	,
cord-343791-0vykwml5	218	17	offering	offer	VBG
cord-343791-0vykwml5	218	18	in	in	IN
cord-343791-0vykwml5	218	19	vivo	vivo	NN
cord-343791-0vykwml5	218	20	protection	protection	NN
cord-343791-0vykwml5	218	21	from	from	IN
cord-343791-0vykwml5	218	22	tumors	tumor	NNS
cord-343791-0vykwml5	218	23	without	without	IN
cord-343791-0vykwml5	218	24	any	any	DT
cord-343791-0vykwml5	218	25	additional	additional	JJ
cord-343791-0vykwml5	218	26	adjuvant	adjuvant	NN
cord-343791-0vykwml5	218	27	.	.	.
cord-343791-0vykwml5	219	1	This	this	DT
cord-343791-0vykwml5	219	2	observation	observation	NN
cord-343791-0vykwml5	219	3	spurred	spur	VBD
cord-343791-0vykwml5	219	4	additional	additional	JJ
cord-343791-0vykwml5	219	5	immunological	immunological	JJ
cord-343791-0vykwml5	219	6	studies	study	NNS
cord-343791-0vykwml5	219	7	to	to	TO
cord-343791-0vykwml5	219	8	expand	expand	VB
cord-343791-0vykwml5	219	9	upon	upon	IN
cord-343791-0vykwml5	219	10	the	the	DT
cord-343791-0vykwml5	219	11	potential	potential	NN
cord-343791-0vykwml5	219	12	of	of	IN
cord-343791-0vykwml5	219	13	peptide	peptide	NNP
cord-343791-0vykwml5	219	14	amphiphile	amphiphile	NNP
cord-343791-0vykwml5	219	15	micelle	micelle	NNP
cord-343791-0vykwml5	219	16	vaccine	vaccine	NN
cord-343791-0vykwml5	219	17	platforms	platform	NNS
cord-343791-0vykwml5	219	18	.	.	.
cord-343791-0vykwml5	220	1	In	in	IN
cord-343791-0vykwml5	220	2	2016	2016	CD
cord-343791-0vykwml5	220	3	,	,	,
cord-343791-0vykwml5	220	4	Barrett	Barrett	NNP
cord-343791-0vykwml5	220	5	et	et	NNP
cord-343791-0vykwml5	220	6	al	al	NNP
cord-343791-0vykwml5	220	7	.	.	NNP
cord-343791-0vykwml5	220	8	used	use	VBD
cord-343791-0vykwml5	220	9	a	a	DT
cord-343791-0vykwml5	220	10	Group	Group	NNP
cord-343791-0vykwml5	220	11	A	A	NNP
cord-343791-0vykwml5	220	12	Streptococcus	streptococcus	NN
cord-343791-0vykwml5	220	13	(	(	-LRB-
cord-343791-0vykwml5	220	14	GAS	gas	NN
cord-343791-0vykwml5	220	15	)	)	-RRB-
cord-343791-0vykwml5	220	16	B	b	NN
cord-343791-0vykwml5	220	17	-	-	HYPH
cord-343791-0vykwml5	220	18	cell	cell	NN
cord-343791-0vykwml5	220	19	antigen	antigen	NN
cord-343791-0vykwml5	220	20	coupled	couple	VBN
cord-343791-0vykwml5	220	21	to	to	IN
cord-343791-0vykwml5	220	22	a	a	DT
cord-343791-0vykwml5	220	23	diC	dic	JJ
cord-343791-0vykwml5	220	24	16	16	CD
cord-343791-0vykwml5	220	25	tail	tail	NN
cord-343791-0vykwml5	220	26	which	which	WDT
cord-343791-0vykwml5	220	27	drove	drive	VBD
cord-343791-0vykwml5	220	28	self	self	NN
cord-343791-0vykwml5	220	29	-	-	HYPH
cord-343791-0vykwml5	220	30	assembly	assembly	NN
cord-343791-0vykwml5	220	31	of	of	IN
cord-343791-0vykwml5	220	32	cylindrical	cylindrical	JJ
cord-343791-0vykwml5	220	33	micelles	micelle	NNS
cord-343791-0vykwml5	220	34	,	,	,
cord-343791-0vykwml5	220	35	to	to	TO
cord-343791-0vykwml5	220	36	induce	induce	VB
cord-343791-0vykwml5	220	37	a	a	DT
cord-343791-0vykwml5	220	38	micelle	micelle	NN
cord-343791-0vykwml5	220	39	-	-	HYPH
cord-343791-0vykwml5	220	40	mediated	mediate	VBN
cord-343791-0vykwml5	220	41	immune	immune	JJ
cord-343791-0vykwml5	220	42	response	response	NN
cord-343791-0vykwml5	220	43	(	(	-LRB-
cord-343791-0vykwml5	220	44	without	without	IN
cord-343791-0vykwml5	220	45	adjuvant	adjuvant	NN
cord-343791-0vykwml5	220	46	)	)	-RRB-
cord-343791-0vykwml5	220	47	that	that	WDT
cord-343791-0vykwml5	220	48	was	be	VBD
cord-343791-0vykwml5	220	49	stronger	strong	JJR
cord-343791-0vykwml5	220	50	than	than	IN
cord-343791-0vykwml5	220	51	seen	see	VBN
cord-343791-0vykwml5	220	52	with	with	IN
cord-343791-0vykwml5	220	53	a	a	DT
cord-343791-0vykwml5	220	54	conventional	conventional	JJ
cord-343791-0vykwml5	220	55	gold	gold	JJ
cord-343791-0vykwml5	220	56	-	-	HYPH
cord-343791-0vykwml5	220	57	standard	standard	NN
cord-343791-0vykwml5	220	58	vaccine	vaccine	NN
cord-343791-0vykwml5	220	59	formulation	formulation	NN
cord-343791-0vykwml5	220	60	.	.	.
cord-343791-0vykwml5	221	1	[	[	-LRB-
cord-343791-0vykwml5	221	2	58	58	CD
cord-343791-0vykwml5	221	3	]	]	-RRB-
cord-343791-0vykwml5	222	1	Although	although	IN
cord-343791-0vykwml5	222	2	spherically	spherically	RB
cord-343791-0vykwml5	222	3	assembled	assemble	VBN
cord-343791-0vykwml5	222	4	peptide	peptide	JJ
cord-343791-0vykwml5	222	5	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	222	6	have	have	VBP
cord-343791-0vykwml5	222	7	not	not	RB
cord-343791-0vykwml5	222	8	yet	yet	RB
cord-343791-0vykwml5	222	9	reached	reach	VBN
cord-343791-0vykwml5	222	10	regulatory	regulatory	JJ
cord-343791-0vykwml5	222	11	approval	approval	NN
cord-343791-0vykwml5	222	12	for	for	IN
cord-343791-0vykwml5	222	13	clinical	clinical	JJ
cord-343791-0vykwml5	222	14	applications	application	NNS
cord-343791-0vykwml5	222	15	,	,	,
cord-343791-0vykwml5	222	16	their	-PRON-	PRP$
cord-343791-0vykwml5	222	17	versatility	versatility	NN
cord-343791-0vykwml5	222	18	,	,	,
cord-343791-0vykwml5	222	19	modularity	modularity	NN
cord-343791-0vykwml5	222	20	,	,	,
cord-343791-0vykwml5	222	21	and	and	CC
cord-343791-0vykwml5	222	22	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	222	23	success	success	NN
cord-343791-0vykwml5	222	24	in	in	IN
cord-343791-0vykwml5	222	25	preclinical	preclinical	JJ
cord-343791-0vykwml5	222	26	work	work	NN
cord-343791-0vykwml5	222	27	is	be	VBZ
cord-343791-0vykwml5	222	28	encouraging	encouraging	JJ
cord-343791-0vykwml5	222	29	.	.	.
cord-343791-0vykwml5	223	1	Clinically	clinically	RB
cord-343791-0vykwml5	223	2	translatable	translatable	JJ
cord-343791-0vykwml5	223	3	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	223	4	materials	material	NNS
cord-343791-0vykwml5	223	5	are	be	VBP
cord-343791-0vykwml5	223	6	not	not	RB
cord-343791-0vykwml5	223	7	limited	limit	VBN
cord-343791-0vykwml5	223	8	to	to	IN
cord-343791-0vykwml5	223	9	spherical	spherical	JJ
cord-343791-0vykwml5	223	10	morphologies	morphology	NNS
cord-343791-0vykwml5	223	11	.	.	.
cord-343791-0vykwml5	224	1	Extended	extended	JJ
cord-343791-0vykwml5	224	2	structures	structure	NNS
cord-343791-0vykwml5	224	3	with	with	IN
cord-343791-0vykwml5	224	4	high	high	JJ
cord-343791-0vykwml5	224	5	aspect	aspect	NN
cord-343791-0vykwml5	224	6	ratios	ratio	NNS
cord-343791-0vykwml5	224	7	have	have	VBP
cord-343791-0vykwml5	224	8	also	also	RB
cord-343791-0vykwml5	224	9	seen	see	VBN
cord-343791-0vykwml5	224	10	considerable	considerable	JJ
cord-343791-0vykwml5	224	11	development	development	NN
cord-343791-0vykwml5	224	12	toward	toward	IN
cord-343791-0vykwml5	224	13	a	a	DT
cord-343791-0vykwml5	224	14	variety	variety	NN
cord-343791-0vykwml5	224	15	of	of	IN
cord-343791-0vykwml5	224	16	medical	medical	JJ
cord-343791-0vykwml5	224	17	technologies	technology	NNS
cord-343791-0vykwml5	224	18	(	(	-LRB-
cord-343791-0vykwml5	224	19	Figure	figure	NN
cord-343791-0vykwml5	224	20	2A	2a	CD
cord-343791-0vykwml5	224	21	-	-	HYPH
cord-343791-0vykwml5	224	22	C	C	NNP
cord-343791-0vykwml5	224	23	)	)	-RRB-
cord-343791-0vykwml5	224	24	.	.	.
cord-343791-0vykwml5	225	1	Prominent	prominent	JJ
cord-343791-0vykwml5	225	2	among	among	IN
cord-343791-0vykwml5	225	3	these	these	DT
cord-343791-0vykwml5	225	4	have	have	VBP
cord-343791-0vykwml5	225	5	been	be	VBN
cord-343791-0vykwml5	225	6	fibrillar	fibrillar	NNP
cord-343791-0vykwml5	225	7	assemblies	assembly	NNS
cord-343791-0vykwml5	225	8	of	of	IN
cord-343791-0vykwml5	225	9	peptides	peptide	NNS
cord-343791-0vykwml5	225	10	and	and	CC
cord-343791-0vykwml5	225	11	their	-PRON-	PRP$
cord-343791-0vykwml5	225	12	derivatives	derivative	NNS
cord-343791-0vykwml5	225	13	.	.	.
cord-343791-0vykwml5	226	1	These	these	DT
cord-343791-0vykwml5	226	2	structures	structure	NNS
cord-343791-0vykwml5	226	3	have	have	VBP
cord-343791-0vykwml5	226	4	been	be	VBN
cord-343791-0vykwml5	226	5	investigated	investigate	VBN
cord-343791-0vykwml5	226	6	over	over	IN
cord-343791-0vykwml5	226	7	the	the	DT
cord-343791-0vykwml5	226	8	past	past	JJ
cord-343791-0vykwml5	226	9	20	20	CD
cord-343791-0vykwml5	226	10	years	year	NNS
cord-343791-0vykwml5	226	11	and	and	CC
cord-343791-0vykwml5	226	12	have	have	VBP
cord-343791-0vykwml5	226	13	made	make	VBN
cord-343791-0vykwml5	226	14	progress	progress	NN
cord-343791-0vykwml5	226	15	toward	toward	IN
cord-343791-0vykwml5	226	16	therapies	therapy	NNS
cord-343791-0vykwml5	226	17	in	in	IN
cord-343791-0vykwml5	226	18	hemostasis	hemostasis	NN
cord-343791-0vykwml5	226	19	,	,	,
cord-343791-0vykwml5	226	20	dentistry	dentistry	NN
cord-343791-0vykwml5	226	21	,	,	,
cord-343791-0vykwml5	226	22	wound	wind	VBN
cord-343791-0vykwml5	226	23	healing	healing	NN
cord-343791-0vykwml5	226	24	,	,	,
cord-343791-0vykwml5	226	25	and	and	CC
cord-343791-0vykwml5	226	26	immunology	immunology	NN
cord-343791-0vykwml5	226	27	.	.	.
cord-343791-0vykwml5	227	1	While	while	IN
cord-343791-0vykwml5	227	2	studying	study	VBG
cord-343791-0vykwml5	227	3	structural	structural	JJ
cord-343791-0vykwml5	227	4	biology	biology	NN
cord-343791-0vykwml5	227	5	in	in	IN
cord-343791-0vykwml5	227	6	Alexander	Alexander	NNP
cord-343791-0vykwml5	227	7	Rich	Rich	NNP
cord-343791-0vykwml5	227	8	's	's	POS
cord-343791-0vykwml5	227	9	research	research	NN
cord-343791-0vykwml5	227	10	group	group	NN
cord-343791-0vykwml5	227	11	,	,	,
cord-343791-0vykwml5	227	12	S.	S.	NNP
cord-343791-0vykwml5	227	13	Zhang	Zhang	NNP
cord-343791-0vykwml5	227	14	discovered	discover	VBD
cord-343791-0vykwml5	227	15	a	a	DT
cord-343791-0vykwml5	227	16	self	self	NN
cord-343791-0vykwml5	227	17	-	-	HYPH
cord-343791-0vykwml5	227	18	assembling	assemble	VBG
cord-343791-0vykwml5	227	19	β	β	NN
cord-343791-0vykwml5	227	20	-	-	HYPH
cord-343791-0vykwml5	227	21	sheet	sheet	NN
cord-343791-0vykwml5	227	22	peptide	peptide	NN
cord-343791-0vykwml5	227	23	based	base	VBN
cord-343791-0vykwml5	227	24	on	on	IN
cord-343791-0vykwml5	227	25	the	the	DT
cord-343791-0vykwml5	227	26	DNA	dna	NN
cord-343791-0vykwml5	227	27	-	-	HYPH
cord-343791-0vykwml5	227	28	binding	bind	VBG
cord-343791-0vykwml5	227	29	protein	protein	NN
cord-343791-0vykwml5	227	30	,	,	,
cord-343791-0vykwml5	227	31	zuotin	zuotin	NNP
cord-343791-0vykwml5	227	32	.	.	.
cord-343791-0vykwml5	228	1	[	[	-LRB-
cord-343791-0vykwml5	228	2	59	59	CD
cord-343791-0vykwml5	228	3	]	]	-RRB-
cord-343791-0vykwml5	229	1	The	the	DT
cord-343791-0vykwml5	229	2	peptide	peptide	NN
cord-343791-0vykwml5	229	3	formed	form	VBD
cord-343791-0vykwml5	229	4	amphiphilic	amphiphilic	JJ
cord-343791-0vykwml5	229	5	tapes	tape	NNS
cord-343791-0vykwml5	229	6	with	with	IN
cord-343791-0vykwml5	229	7	two	two	CD
cord-343791-0vykwml5	229	8	distinct	distinct	JJ
cord-343791-0vykwml5	229	9	surfaces	surface	NNS
cord-343791-0vykwml5	229	10	,	,	,
cord-343791-0vykwml5	229	11	one	one	CD
cord-343791-0vykwml5	229	12	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	229	13	and	and	CC
cord-343791-0vykwml5	229	14	the	the	DT
cord-343791-0vykwml5	229	15	other	other	JJ
cord-343791-0vykwml5	229	16	hydrophilic	hydrophilic	NN
cord-343791-0vykwml5	229	17	,	,	,
cord-343791-0vykwml5	229	18	and	and	CC
cord-343791-0vykwml5	229	19	it	-PRON-	PRP
cord-343791-0vykwml5	229	20	also	also	RB
cord-343791-0vykwml5	229	21	contained	contain	VBD
cord-343791-0vykwml5	229	22	complementary	complementary	JJ
cord-343791-0vykwml5	229	23	charged	charge	VBN
cord-343791-0vykwml5	229	24	residues	residue	NNS
cord-343791-0vykwml5	229	25	that	that	WDT
cord-343791-0vykwml5	229	26	additionally	additionally	RB
cord-343791-0vykwml5	229	27	favored	favor	VBD
cord-343791-0vykwml5	229	28	this	this	DT
cord-343791-0vykwml5	229	29	β	β	NN
cord-343791-0vykwml5	229	30	-	-	HYPH
cord-343791-0vykwml5	229	31	sheet	sheet	NN
cord-343791-0vykwml5	229	32	folding	folding	NN
cord-343791-0vykwml5	229	33	(	(	-LRB-
cord-343791-0vykwml5	229	34	see	see	VB
cord-343791-0vykwml5	229	35	Figure	figure	NN
cord-343791-0vykwml5	229	36	2B	2b	CD
cord-343791-0vykwml5	229	37	)	)	-RRB-
cord-343791-0vykwml5	229	38	.	.	.
cord-343791-0vykwml5	230	1	Following	follow	VBG
cord-343791-0vykwml5	230	2	this	this	DT
cord-343791-0vykwml5	230	3	discovery	discovery	NN
cord-343791-0vykwml5	230	4	,	,	,
cord-343791-0vykwml5	230	5	a	a	DT
cord-343791-0vykwml5	230	6	mimic	mimic	NN
cord-343791-0vykwml5	230	7	of	of	IN
cord-343791-0vykwml5	230	8	the	the	DT
cord-343791-0vykwml5	230	9	native	native	JJ
cord-343791-0vykwml5	230	10	peptide	peptide	NN
cord-343791-0vykwml5	230	11	was	be	VBD
cord-343791-0vykwml5	230	12	designed	design	VBN
cord-343791-0vykwml5	230	13	by	by	IN
cord-343791-0vykwml5	230	14	mutating	mutate	VBG
cord-343791-0vykwml5	230	15	the	the	DT
cord-343791-0vykwml5	230	16	charged	charge	VBN
cord-343791-0vykwml5	230	17	and	and	CC
cord-343791-0vykwml5	230	18	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	230	19	residues	residue	NNS
cord-343791-0vykwml5	230	20	,	,	,
cord-343791-0vykwml5	230	21	but	but	CC
cord-343791-0vykwml5	230	22	leaving	leave	VBG
cord-343791-0vykwml5	230	23	the	the	DT
cord-343791-0vykwml5	230	24	pattern	pattern	NN
cord-343791-0vykwml5	230	25	intact	intact	JJ
cord-343791-0vykwml5	230	26	.	.	.
cord-343791-0vykwml5	231	1	[	[	-LRB-
cord-343791-0vykwml5	231	2	60	60	CD
cord-343791-0vykwml5	231	3	]	]	-RRB-
cord-343791-0vykwml5	232	1	This	this	DT
cord-343791-0vykwml5	232	2	mimic	mimic	NN
cord-343791-0vykwml5	232	3	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	232	4	that	that	IN
cord-343791-0vykwml5	232	5	self	self	NN
cord-343791-0vykwml5	232	6	-	-	HYPH
cord-343791-0vykwml5	232	7	assembly	assembly	NN
cord-343791-0vykwml5	232	8	of	of	IN
cord-343791-0vykwml5	232	9	peptides	peptide	NNS
cord-343791-0vykwml5	232	10	with	with	IN
cord-343791-0vykwml5	232	11	these	these	DT
cord-343791-0vykwml5	232	12	motifs	motif	NNS
cord-343791-0vykwml5	232	13	was	be	VBD
cord-343791-0vykwml5	232	14	not	not	RB
cord-343791-0vykwml5	232	15	a	a	DT
cord-343791-0vykwml5	232	16	sequence	sequence	NN
cord-343791-0vykwml5	232	17	-	-	HYPH
cord-343791-0vykwml5	232	18	specific	specific	JJ
cord-343791-0vykwml5	232	19	anomaly	anomaly	NN
cord-343791-0vykwml5	232	20	,	,	,
cord-343791-0vykwml5	232	21	but	but	CC
cord-343791-0vykwml5	232	22	could	could	MD
cord-343791-0vykwml5	232	23	be	be	VB
cord-343791-0vykwml5	232	24	recreated	recreate	VBN
cord-343791-0vykwml5	232	25	in	in	IN
cord-343791-0vykwml5	232	26	similar	similar	JJ
cord-343791-0vykwml5	232	27	systems	system	NNS
cord-343791-0vykwml5	232	28	,	,	,
cord-343791-0vykwml5	232	29	forming	form	VBG
cord-343791-0vykwml5	232	30	the	the	DT
cord-343791-0vykwml5	232	31	first	first	JJ
cord-343791-0vykwml5	232	32	steps	step	NNS
cord-343791-0vykwml5	232	33	toward	toward	IN
cord-343791-0vykwml5	232	34	design	design	NN
cord-343791-0vykwml5	232	35	rules	rule	NNS
cord-343791-0vykwml5	232	36	for	for	IN
cord-343791-0vykwml5	232	37	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	232	38	peptides	peptide	NNS
cord-343791-0vykwml5	232	39	.	.	.
cord-343791-0vykwml5	233	1	The	the	DT
cord-343791-0vykwml5	233	2	designer	designer	NN
cord-343791-0vykwml5	233	3	peptide	peptide	NN
cord-343791-0vykwml5	233	4	was	be	VBD
cord-343791-0vykwml5	233	5	shown	show	VBN
cord-343791-0vykwml5	233	6	to	to	TO
cord-343791-0vykwml5	233	7	also	also	RB
cord-343791-0vykwml5	233	8	form	form	VB
cord-343791-0vykwml5	233	9	macroscopic	macroscopic	JJ
cord-343791-0vykwml5	233	10	membranes	membrane	NNS
cord-343791-0vykwml5	233	11	and	and	CC
cord-343791-0vykwml5	233	12	support	support	VBP
cord-343791-0vykwml5	233	13	the	the	DT
cord-343791-0vykwml5	233	14	attachment	attachment	NN
cord-343791-0vykwml5	233	15	of	of	IN
cord-343791-0vykwml5	233	16	mammalian	mammalian	JJ
cord-343791-0vykwml5	233	17	cells	cell	NNS
cord-343791-0vykwml5	233	18	,	,	,
cord-343791-0vykwml5	233	19	demonstrating	demonstrate	VBG
cord-343791-0vykwml5	233	20	its	-PRON-	PRP$
cord-343791-0vykwml5	233	21	utility	utility	NN
cord-343791-0vykwml5	233	22	as	as	IN
cord-343791-0vykwml5	233	23	a	a	DT
cord-343791-0vykwml5	233	24	biomaterial	biomaterial	NN
cord-343791-0vykwml5	233	25	.	.	.
cord-343791-0vykwml5	234	1	[	[	-LRB-
cord-343791-0vykwml5	234	2	61	61	CD
cord-343791-0vykwml5	234	3	]	]	-RRB-
cord-343791-0vykwml5	235	1	Subsequently	subsequently	RB
cord-343791-0vykwml5	235	2	,	,	,
cord-343791-0vykwml5	235	3	it	-PRON-	PRP
cord-343791-0vykwml5	235	4	was	be	VBD
cord-343791-0vykwml5	235	5	found	find	VBN
cord-343791-0vykwml5	235	6	that	that	IN
cord-343791-0vykwml5	235	7	the	the	DT
cord-343791-0vykwml5	235	8	original	original	JJ
cord-343791-0vykwml5	235	9	synthetic	synthetic	JJ
cord-343791-0vykwml5	235	10	sequence	sequence	NN
cord-343791-0vykwml5	235	11	RADA16-II	RADA16-II	NNP
cord-343791-0vykwml5	235	12	(	(	-LRB-
cord-343791-0vykwml5	235	13	RARADADA	RARADADA	NNP
cord-343791-0vykwml5	235	14	)	)	-RRB-
cord-343791-0vykwml5	235	15	2	2	CD
cord-343791-0vykwml5	235	16	and	and	CC
cord-343791-0vykwml5	235	17	its	-PRON-	PRP$
cord-343791-0vykwml5	235	18	modified	modify	VBN
cord-343791-0vykwml5	235	19	form	form	NN
cord-343791-0vykwml5	235	20	RADA16-I	RADA16-I	NNP
cord-343791-0vykwml5	235	21	(	(	-LRB-
cord-343791-0vykwml5	235	22	RADA	RADA	NNP
cord-343791-0vykwml5	235	23	)	)	-RRB-
cord-343791-0vykwml5	235	24	4	4	CD
cord-343791-0vykwml5	235	25	spontaneously	spontaneously	RB
cord-343791-0vykwml5	235	26	formed	form	VBN
cord-343791-0vykwml5	235	27	hydrogels	hydrogel	NNS
cord-343791-0vykwml5	235	28	of	of	IN
cord-343791-0vykwml5	235	29	entangled	entangle	VBN
cord-343791-0vykwml5	235	30	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	235	31	in	in	IN
cord-343791-0vykwml5	235	32	salt	salt	NN
cord-343791-0vykwml5	235	33	-	-	HYPH
cord-343791-0vykwml5	235	34	containing	contain	VBG
cord-343791-0vykwml5	235	35	solutions	solution	NNS
cord-343791-0vykwml5	235	36	and	and	CC
cord-343791-0vykwml5	235	37	cell	cell	NN
cord-343791-0vykwml5	235	38	culture	culture	NN
cord-343791-0vykwml5	235	39	media	medium	NNS
cord-343791-0vykwml5	235	40	.	.	.
cord-343791-0vykwml5	236	1	[	[	-LRB-
cord-343791-0vykwml5	236	2	62	62	CD
cord-343791-0vykwml5	236	3	]	]	-RRB-
cord-343791-0vykwml5	236	4	Mixtures	mixture	NNS
cord-343791-0vykwml5	236	5	of	of	IN
cord-343791-0vykwml5	236	6	peptides	peptide	NNS
cord-343791-0vykwml5	236	7	bearing	bear	VBG
cord-343791-0vykwml5	236	8	multiple	multiple	JJ
cord-343791-0vykwml5	236	9	bioactive	bioactive	JJ
cord-343791-0vykwml5	236	10	groups	group	NNS
cord-343791-0vykwml5	236	11	could	could	MD
cord-343791-0vykwml5	236	12	be	be	VB
cord-343791-0vykwml5	236	13	incorporated	incorporate	VBN
cord-343791-0vykwml5	236	14	into	into	IN
cord-343791-0vykwml5	236	15	a	a	DT
cord-343791-0vykwml5	236	16	single	single	JJ
cord-343791-0vykwml5	236	17	macroscopic	macroscopic	JJ
cord-343791-0vykwml5	236	18	gel	gel	NN
cord-343791-0vykwml5	236	19	by	by	IN
cord-343791-0vykwml5	236	20	dosing	dose	VBG
cord-343791-0vykwml5	236	21	in	in	IN
cord-343791-0vykwml5	236	22	various	various	JJ
cord-343791-0vykwml5	236	23	amounts	amount	NNS
cord-343791-0vykwml5	236	24	of	of	IN
cord-343791-0vykwml5	236	25	monomeric	monomeric	JJ
cord-343791-0vykwml5	236	26	peptides	peptide	NNS
cord-343791-0vykwml5	236	27	to	to	IN
cord-343791-0vykwml5	236	28	the	the	DT
cord-343791-0vykwml5	236	29	gel	gel	NN
cord-343791-0vykwml5	236	30	mixture	mixture	NN
cord-343791-0vykwml5	236	31	.	.	.
cord-343791-0vykwml5	237	1	Additionally	additionally	RB
cord-343791-0vykwml5	237	2	,	,	,
cord-343791-0vykwml5	237	3	the	the	DT
cord-343791-0vykwml5	237	4	incorporation	incorporation	NN
cord-343791-0vykwml5	237	5	of	of	IN
cord-343791-0vykwml5	237	6	ligands	ligand	NNS
cord-343791-0vykwml5	237	7	or	or	CC
cord-343791-0vykwml5	237	8	epitopes	epitope	NNS
cord-343791-0vykwml5	237	9	within	within	IN
cord-343791-0vykwml5	237	10	the	the	DT
cord-343791-0vykwml5	237	11	materials	material	NNS
cord-343791-0vykwml5	237	12	simply	simply	RB
cord-343791-0vykwml5	237	13	required	require	VBD
cord-343791-0vykwml5	237	14	extension	extension	NN
cord-343791-0vykwml5	237	15	of	of	IN
cord-343791-0vykwml5	237	16	the	the	DT
cord-343791-0vykwml5	237	17	peptide	peptide	NN
cord-343791-0vykwml5	237	18	at	at	IN
cord-343791-0vykwml5	237	19	either	either	DT
cord-343791-0vykwml5	237	20	terminus	terminus	NN
cord-343791-0vykwml5	237	21	with	with	IN
cord-343791-0vykwml5	237	22	the	the	DT
cord-343791-0vykwml5	237	23	desired	desire	VBN
cord-343791-0vykwml5	237	24	sequence	sequence	NN
cord-343791-0vykwml5	237	25	,	,	,
cord-343791-0vykwml5	237	26	thus	thus	RB
cord-343791-0vykwml5	237	27	lowering	lower	VBG
cord-343791-0vykwml5	237	28	the	the	DT
cord-343791-0vykwml5	237	29	barrier	barrier	NN
cord-343791-0vykwml5	237	30	of	of	IN
cord-343791-0vykwml5	237	31	synthetic	synthetic	JJ
cord-343791-0vykwml5	237	32	difficulty	difficulty	NN
cord-343791-0vykwml5	237	33	for	for	IN
cord-343791-0vykwml5	237	34	biological	biological	JJ
cord-343791-0vykwml5	237	35	researchers	researcher	NNS
cord-343791-0vykwml5	237	36	.	.	.
cord-343791-0vykwml5	238	1	These	these	DT
cord-343791-0vykwml5	238	2	gels	gel	NNS
cord-343791-0vykwml5	238	3	have	have	VBP
cord-343791-0vykwml5	238	4	been	be	VBN
cord-343791-0vykwml5	238	5	subsequently	subsequently	RB
cord-343791-0vykwml5	238	6	developed	develop	VBN
cord-343791-0vykwml5	238	7	toward	toward	IN
cord-343791-0vykwml5	238	8	neuronal	neuronal	JJ
cord-343791-0vykwml5	238	9	regeneration	regeneration	NN
cord-343791-0vykwml5	238	10	,	,	,
cord-343791-0vykwml5	238	11	cytokine	cytokine	NN
cord-343791-0vykwml5	238	12	delivery	delivery	NN
cord-343791-0vykwml5	238	13	,	,	,
cord-343791-0vykwml5	238	14	as	as	IN
cord-343791-0vykwml5	238	15	biotinylated	biotinylate	VBN
cord-343791-0vykwml5	238	16	scaffolds	scaffold	NNS
cord-343791-0vykwml5	238	17	for	for	IN
cord-343791-0vykwml5	238	18	versatile	versatile	JJ
cord-343791-0vykwml5	238	19	protein	protein	NN
cord-343791-0vykwml5	238	20	delivery	delivery	NN
cord-343791-0vykwml5	238	21	,	,	,
cord-343791-0vykwml5	238	22	and	and	CC
cord-343791-0vykwml5	238	23	other	other	JJ
cord-343791-0vykwml5	238	24	applications	application	NNS
cord-343791-0vykwml5	238	25	.	.	.
cord-343791-0vykwml5	239	1	[	[	-LRB-
cord-343791-0vykwml5	239	2	62	62	CD
cord-343791-0vykwml5	239	3	]	]	-RRB-
cord-343791-0vykwml5	239	4	[	[	-LRB-
cord-343791-0vykwml5	239	5	63	63	CD
cord-343791-0vykwml5	239	6	]	]	-RRB-
cord-343791-0vykwml5	240	1	[	[	-LRB-
cord-343791-0vykwml5	240	2	64	64	CD
cord-343791-0vykwml5	240	3	]	]	-RRB-
cord-343791-0vykwml5	241	1	The	the	DT
cord-343791-0vykwml5	241	2	release	release	NN
cord-343791-0vykwml5	241	3	of	of	IN
cord-343791-0vykwml5	241	4	proteins	protein	NNS
cord-343791-0vykwml5	241	5	and	and	CC
cord-343791-0vykwml5	241	6	small	small	JJ
cord-343791-0vykwml5	241	7	molecules	molecule	NNS
cord-343791-0vykwml5	241	8	from	from	IN
cord-343791-0vykwml5	241	9	RADA	RADA	NNP
cord-343791-0vykwml5	241	10	hydrogels	hydrogel	NNS
cord-343791-0vykwml5	241	11	largely	largely	RB
cord-343791-0vykwml5	241	12	depends	depend	VBZ
cord-343791-0vykwml5	241	13	on	on	IN
cord-343791-0vykwml5	241	14	the	the	DT
cord-343791-0vykwml5	241	15	size	size	NN
cord-343791-0vykwml5	241	16	of	of	IN
cord-343791-0vykwml5	241	17	the	the	DT
cord-343791-0vykwml5	241	18	protein	protein	NN
cord-343791-0vykwml5	241	19	cargo	cargo	NN
cord-343791-0vykwml5	241	20	regardless	regardless	RB
cord-343791-0vykwml5	241	21	of	of	IN
cord-343791-0vykwml5	241	22	charge	charge	NN
cord-343791-0vykwml5	241	23	and	and	CC
cord-343791-0vykwml5	241	24	hydrophilic	hydrophilic	JJ
cord-343791-0vykwml5	241	25	character	character	NN
cord-343791-0vykwml5	241	26	,	,	,
cord-343791-0vykwml5	241	27	allowing	allow	VBG
cord-343791-0vykwml5	241	28	a	a	DT
cord-343791-0vykwml5	241	29	wide	wide	JJ
cord-343791-0vykwml5	241	30	variety	variety	NN
cord-343791-0vykwml5	241	31	of	of	IN
cord-343791-0vykwml5	241	32	biomolecules	biomolecule	NNS
cord-343791-0vykwml5	241	33	to	to	TO
cord-343791-0vykwml5	241	34	be	be	VB
cord-343791-0vykwml5	241	35	delivered	deliver	VBN
cord-343791-0vykwml5	241	36	in	in	IN
cord-343791-0vykwml5	241	37	these	these	DT
cord-343791-0vykwml5	241	38	gels	gel	NNS
cord-343791-0vykwml5	241	39	.	.	.
cord-343791-0vykwml5	242	1	[	[	-LRB-
cord-343791-0vykwml5	242	2	65	65	CD
cord-343791-0vykwml5	242	3	]	]	-RRB-
cord-343791-0vykwml5	243	1	Besides	besides	IN
cord-343791-0vykwml5	243	2	physical	physical	JJ
cord-343791-0vykwml5	243	3	entrapment	entrapment	NN
cord-343791-0vykwml5	243	4	,	,	,
cord-343791-0vykwml5	243	5	a	a	DT
cord-343791-0vykwml5	243	6	biotin	biotin	NN
cord-343791-0vykwml5	243	7	-	-	HYPH
cord-343791-0vykwml5	243	8	sandwich	sandwich	NN
cord-343791-0vykwml5	243	9	approach	approach	NN
cord-343791-0vykwml5	243	10	has	have	VBZ
cord-343791-0vykwml5	243	11	been	be	VBN
cord-343791-0vykwml5	243	12	used	use	VBN
cord-343791-0vykwml5	243	13	to	to	TO
cord-343791-0vykwml5	243	14	tether	tether	VB
cord-343791-0vykwml5	243	15	insulin	insulin	NN
cord-343791-0vykwml5	243	16	-	-	HYPH
cord-343791-0vykwml5	243	17	like	like	JJ
cord-343791-0vykwml5	243	18	growth	growth	NN
cord-343791-0vykwml5	243	19	factor	factor	NN
cord-343791-0vykwml5	243	20	1	1	CD
cord-343791-0vykwml5	243	21	(	(	-LRB-
cord-343791-0vykwml5	243	22	IGF-1	IGF-1	NNP
cord-343791-0vykwml5	243	23	)	)	-RRB-
cord-343791-0vykwml5	243	24	to	to	IN
cord-343791-0vykwml5	243	25	gels	gel	NNS
cord-343791-0vykwml5	243	26	for	for	IN
cord-343791-0vykwml5	243	27	long	long	JJ
cord-343791-0vykwml5	243	28	term	term	NN
cord-343791-0vykwml5	243	29	localization	localization	NN
cord-343791-0vykwml5	243	30	of	of	IN
cord-343791-0vykwml5	243	31	bioactive	bioactive	JJ
cord-343791-0vykwml5	243	32	IGF-1	IGF-1	NNP
cord-343791-0vykwml5	243	33	in	in	IN
cord-343791-0vykwml5	243	34	the	the	DT
cord-343791-0vykwml5	243	35	scaffold	scaffold	NN
cord-343791-0vykwml5	243	36	.	.	.
cord-343791-0vykwml5	244	1	[	[	-LRB-
cord-343791-0vykwml5	244	2	63	63	CD
cord-343791-0vykwml5	244	3	]	]	-RRB-
cord-343791-0vykwml5	244	4	Biotinylation	Biotinylation	NNP
cord-343791-0vykwml5	244	5	provides	provide	VBZ
cord-343791-0vykwml5	244	6	the	the	DT
cord-343791-0vykwml5	244	7	advantage	advantage	NN
cord-343791-0vykwml5	244	8	of	of	IN
cord-343791-0vykwml5	244	9	modularity	modularity	NN
cord-343791-0vykwml5	244	10	within	within	IN
cord-343791-0vykwml5	244	11	the	the	DT
cord-343791-0vykwml5	244	12	hydrogel	hydrogel	NN
cord-343791-0vykwml5	244	13	delivery	delivery	NN
cord-343791-0vykwml5	244	14	system	system	NN
cord-343791-0vykwml5	244	15	,	,	,
cord-343791-0vykwml5	244	16	as	as	IN
cord-343791-0vykwml5	244	17	any	any	DT
cord-343791-0vykwml5	244	18	biotinylated	biotinylated	JJ
cord-343791-0vykwml5	244	19	protein	protein	NN
cord-343791-0vykwml5	244	20	can	can	MD
cord-343791-0vykwml5	244	21	be	be	VB
cord-343791-0vykwml5	244	22	immobilized	immobilize	VBN
cord-343791-0vykwml5	244	23	to	to	IN
cord-343791-0vykwml5	244	24	biotinylated	biotinylated	JJ
cord-343791-0vykwml5	244	25	fibers	fiber	NNS
cord-343791-0vykwml5	244	26	via	via	IN
cord-343791-0vykwml5	244	27	a	a	DT
cord-343791-0vykwml5	244	28	streptavidin	streptavidin	NNP
cord-343791-0vykwml5	244	29	linkage	linkage	NN
cord-343791-0vykwml5	244	30	.	.	.
cord-343791-0vykwml5	245	1	Biotinylated	biotinylated	JJ
cord-343791-0vykwml5	245	2	fibers	fiber	NNS
cord-343791-0vykwml5	245	3	have	have	VBP
cord-343791-0vykwml5	245	4	been	be	VBN
cord-343791-0vykwml5	245	5	investigated	investigate	VBN
cord-343791-0vykwml5	245	6	for	for	IN
cord-343791-0vykwml5	245	7	myocardial	myocardial	JJ
cord-343791-0vykwml5	245	8	regeneration	regeneration	NN
cord-343791-0vykwml5	245	9	following	follow	VBG
cord-343791-0vykwml5	245	10	infarction	infarction	NN
cord-343791-0vykwml5	245	11	and	and	CC
cord-343791-0vykwml5	245	12	showed	show	VBD
cord-343791-0vykwml5	245	13	success	success	NN
cord-343791-0vykwml5	245	14	in	in	IN
cord-343791-0vykwml5	245	15	rats	rat	NNS
cord-343791-0vykwml5	245	16	when	when	WRB
cord-343791-0vykwml5	245	17	injected	inject	VBN
cord-343791-0vykwml5	245	18	into	into	IN
cord-343791-0vykwml5	245	19	infarcted	infarcted	JJ
cord-343791-0vykwml5	245	20	hearts	heart	NNS
cord-343791-0vykwml5	245	21	along	along	IN
cord-343791-0vykwml5	245	22	with	with	IN
cord-343791-0vykwml5	245	23	cardiac	cardiac	JJ
cord-343791-0vykwml5	245	24	progenitor	progenitor	NN
cord-343791-0vykwml5	245	25	cells	cell	NNS
cord-343791-0vykwml5	245	26	.	.	.
cord-343791-0vykwml5	246	1	[	[	-LRB-
cord-343791-0vykwml5	246	2	66	66	CD
cord-343791-0vykwml5	246	3	]	]	-RRB-
cord-343791-0vykwml5	247	1	Although	although	IN
cord-343791-0vykwml5	247	2	RADA	RADA	NNP
cord-343791-0vykwml5	247	3	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	247	4	have	have	VBP
cord-343791-0vykwml5	247	5	been	be	VBN
cord-343791-0vykwml5	247	6	investigated	investigate	VBN
cord-343791-0vykwml5	247	7	preclinically	preclinically	RB
cord-343791-0vykwml5	247	8	for	for	IN
cord-343791-0vykwml5	247	9	a	a	DT
cord-343791-0vykwml5	247	10	wide	wide	JJ
cord-343791-0vykwml5	247	11	range	range	NN
cord-343791-0vykwml5	247	12	of	of	IN
cord-343791-0vykwml5	247	13	medical	medical	JJ
cord-343791-0vykwml5	247	14	applications	application	NNS
cord-343791-0vykwml5	247	15	,	,	,
cord-343791-0vykwml5	247	16	they	-PRON-	PRP
cord-343791-0vykwml5	247	17	have	have	VBP
cord-343791-0vykwml5	247	18	had	have	VBN
cord-343791-0vykwml5	247	19	the	the	DT
cord-343791-0vykwml5	247	20	most	most	RBS
cord-343791-0vykwml5	247	21	clinical	clinical	JJ
cord-343791-0vykwml5	247	22	success	success	NN
cord-343791-0vykwml5	247	23	as	as	IN
cord-343791-0vykwml5	247	24	a	a	DT
cord-343791-0vykwml5	247	25	hemostatic	hemostatic	JJ
cord-343791-0vykwml5	247	26	agent	agent	NN
cord-343791-0vykwml5	247	27	.	.	.
cord-343791-0vykwml5	248	1	Marketed	market	VBN
cord-343791-0vykwml5	248	2	under	under	IN
cord-343791-0vykwml5	248	3	the	the	DT
cord-343791-0vykwml5	248	4	trade	trade	NN
cord-343791-0vykwml5	248	5	name	name	NN
cord-343791-0vykwml5	248	6	Purastat	Purastat	NNP
cord-343791-0vykwml5	248	7	by	by	IN
cord-343791-0vykwml5	248	8	3-D	3-D	NNP
cord-343791-0vykwml5	248	9	Matrix	Matrix	NNP
cord-343791-0vykwml5	248	10	Ltd.	Ltd.	NNP
cord-343791-0vykwml5	248	11	,	,	,
cord-343791-0vykwml5	248	12	[	[	-LRB-
cord-343791-0vykwml5	248	13	67	67	CD
cord-343791-0vykwml5	248	14	]	]	-RRB-
cord-343791-0vykwml5	248	15	the	the	DT
cord-343791-0vykwml5	248	16	product	product	NN
cord-343791-0vykwml5	248	17	is	be	VBZ
cord-343791-0vykwml5	248	18	composed	compose	VBN
cord-343791-0vykwml5	248	19	solely	solely	RB
cord-343791-0vykwml5	248	20	of	of	IN
cord-343791-0vykwml5	248	21	peptide	peptide	NN
cord-343791-0vykwml5	248	22	dissolved	dissolve	VBN
cord-343791-0vykwml5	248	23	in	in	IN
cord-343791-0vykwml5	248	24	sterile	sterile	JJ
cord-343791-0vykwml5	248	25	water	water	NN
cord-343791-0vykwml5	248	26	,	,	,
cord-343791-0vykwml5	248	27	which	which	WDT
cord-343791-0vykwml5	248	28	forms	form	VBZ
cord-343791-0vykwml5	248	29	fibers	fiber	NNS
cord-343791-0vykwml5	248	30	when	when	WRB
cord-343791-0vykwml5	248	31	in	in	IN
cord-343791-0vykwml5	248	32	contact	contact	NN
cord-343791-0vykwml5	248	33	with	with	IN
cord-343791-0vykwml5	248	34	biological	biological	JJ
cord-343791-0vykwml5	248	35	fluids	fluid	NNS
cord-343791-0vykwml5	248	36	.	.	.
cord-343791-0vykwml5	249	1	This	this	DT
cord-343791-0vykwml5	249	2	self	self	NN
cord-343791-0vykwml5	249	3	-	-	HYPH
cord-343791-0vykwml5	249	4	assembly	assembly	NN
cord-343791-0vykwml5	249	5	provides	provide	VBZ
cord-343791-0vykwml5	249	6	a	a	DT
cord-343791-0vykwml5	249	7	physical	physical	JJ
cord-343791-0vykwml5	249	8	blockage	blockage	NN
cord-343791-0vykwml5	249	9	in	in	IN
cord-343791-0vykwml5	249	10	order	order	NN
cord-343791-0vykwml5	249	11	to	to	TO
cord-343791-0vykwml5	249	12	limit	limit	VB
cord-343791-0vykwml5	249	13	bleeding	bleeding	NN
cord-343791-0vykwml5	249	14	at	at	IN
cord-343791-0vykwml5	249	15	the	the	DT
cord-343791-0vykwml5	249	16	site	site	NN
cord-343791-0vykwml5	249	17	of	of	IN
cord-343791-0vykwml5	249	18	application	application	NN
cord-343791-0vykwml5	249	19	.	.	.
cord-343791-0vykwml5	250	1	Although	although	IN
cord-343791-0vykwml5	250	2	this	this	DT
cord-343791-0vykwml5	250	3	peptide	peptide	NN
cord-343791-0vykwml5	250	4	's	's	POS
cord-343791-0vykwml5	250	5	use	use	NN
cord-343791-0vykwml5	250	6	as	as	IN
cord-343791-0vykwml5	250	7	a	a	DT
cord-343791-0vykwml5	250	8	hemostat	hemostat	NN
cord-343791-0vykwml5	250	9	is	be	VBZ
cord-343791-0vykwml5	250	10	still	still	RB
cord-343791-0vykwml5	250	11	being	be	VBG
cord-343791-0vykwml5	250	12	actively	actively	RB
cord-343791-0vykwml5	250	13	developed	develop	VBN
cord-343791-0vykwml5	250	14	as	as	IN
cord-343791-0vykwml5	250	15	a	a	DT
cord-343791-0vykwml5	250	16	component	component	NN
cord-343791-0vykwml5	250	17	of	of	IN
cord-343791-0vykwml5	250	18	layer	layer	NN
cord-343791-0vykwml5	250	19	-	-	HYPH
cord-343791-0vykwml5	250	20	by	by	IN
cord-343791-0vykwml5	250	21	-	-	HYPH
cord-343791-0vykwml5	250	22	layer	layer	NN
cord-343791-0vykwml5	250	23	wound	wound	NN
cord-343791-0vykwml5	250	24	dressings	dressing	NNS
cord-343791-0vykwml5	250	25	,	,	,
cord-343791-0vykwml5	250	26	[	[	-LRB-
cord-343791-0vykwml5	250	27	68	68	CD
cord-343791-0vykwml5	250	28	]	]	-RRB-
cord-343791-0vykwml5	251	1	the	the	DT
cord-343791-0vykwml5	251	2	original	original	JJ
cord-343791-0vykwml5	251	3	RADA16-I	RADA16-I	NNP
cord-343791-0vykwml5	251	4	peptide	peptide	NN
cord-343791-0vykwml5	251	5	has	have	VBZ
cord-343791-0vykwml5	251	6	been	be	VBN
cord-343791-0vykwml5	251	7	useful	useful	JJ
cord-343791-0vykwml5	251	8	as	as	IN
cord-343791-0vykwml5	251	9	a	a	DT
cord-343791-0vykwml5	251	10	surgical	surgical	JJ
cord-343791-0vykwml5	251	11	hemostat	hemostat	NN
cord-343791-0vykwml5	251	12	for	for	IN
cord-343791-0vykwml5	251	13	multiple	multiple	JJ
cord-343791-0vykwml5	251	14	surgeries	surgery	NNS
cord-343791-0vykwml5	251	15	because	because	IN
cord-343791-0vykwml5	251	16	of	of	IN
cord-343791-0vykwml5	251	17	the	the	DT
cord-343791-0vykwml5	251	18	dense	dense	JJ
cord-343791-0vykwml5	251	19	mesh	mesh	NN
cord-343791-0vykwml5	251	20	it	-PRON-	PRP
cord-343791-0vykwml5	251	21	creates	create	VBZ
cord-343791-0vykwml5	251	22	at	at	IN
cord-343791-0vykwml5	251	23	neutral	neutral	JJ
cord-343791-0vykwml5	251	24	pH.	ph.	NN
cord-343791-0vykwml5	252	1	The	the	DT
cord-343791-0vykwml5	252	2	RADA16-I	RADA16-I	NNP
cord-343791-0vykwml5	252	3	peptide	peptide	NN
cord-343791-0vykwml5	252	4	which	which	WDT
cord-343791-0vykwml5	252	5	became	become	VBD
cord-343791-0vykwml5	252	6	Purastat	Purastat	NNP
cord-343791-0vykwml5	252	7	was	be	VBD
cord-343791-0vykwml5	252	8	first	first	RB
cord-343791-0vykwml5	252	9	tested	test	VBN
cord-343791-0vykwml5	252	10	as	as	IN
cord-343791-0vykwml5	252	11	a	a	DT
cord-343791-0vykwml5	252	12	hemostatic	hemostatic	JJ
cord-343791-0vykwml5	252	13	agent	agent	NN
cord-343791-0vykwml5	252	14	in	in	IN
cord-343791-0vykwml5	252	15	2006	2006	CD
cord-343791-0vykwml5	252	16	and	and	CC
cord-343791-0vykwml5	252	17	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	252	18	hemostasis	hemostasis	NN
cord-343791-0vykwml5	252	19	in	in	IN
cord-343791-0vykwml5	252	20	rats	rat	NNS
cord-343791-0vykwml5	252	21	by	by	IN
cord-343791-0vykwml5	252	22	stopping	stop	VBG
cord-343791-0vykwml5	252	23	bleeding	bleed	VBG
cord-343791-0vykwml5	252	24	in	in	RP
cord-343791-0vykwml5	252	25	under	under	IN
cord-343791-0vykwml5	252	26	15	15	CD
cord-343791-0vykwml5	252	27	s	s	NNS
cord-343791-0vykwml5	252	28	when	when	WRB
cord-343791-0vykwml5	252	29	applied	apply	VBN
cord-343791-0vykwml5	252	30	as	as	IN
cord-343791-0vykwml5	252	31	a	a	DT
cord-343791-0vykwml5	252	32	3%-4	3%-4	CD
cord-343791-0vykwml5	252	33	%	%	NN
cord-343791-0vykwml5	252	34	aqueous	aqueous	JJ
cord-343791-0vykwml5	252	35	solution	solution	NN
cord-343791-0vykwml5	252	36	to	to	IN
cord-343791-0vykwml5	252	37	wounds	wound	NNS
cord-343791-0vykwml5	252	38	in	in	IN
cord-343791-0vykwml5	252	39	skin	skin	NN
cord-343791-0vykwml5	252	40	,	,	,
cord-343791-0vykwml5	252	41	brain	brain	NN
cord-343791-0vykwml5	252	42	,	,	,
cord-343791-0vykwml5	252	43	spinal	spinal	JJ
cord-343791-0vykwml5	252	44	cord	cord	NN
cord-343791-0vykwml5	252	45	,	,	,
cord-343791-0vykwml5	252	46	femoral	femoral	JJ
cord-343791-0vykwml5	252	47	artery	artery	NN
cord-343791-0vykwml5	252	48	,	,	,
cord-343791-0vykwml5	252	49	and	and	CC
cord-343791-0vykwml5	252	50	liver	liver	NN
cord-343791-0vykwml5	252	51	.	.	.
cord-343791-0vykwml5	253	1	[	[	-LRB-
cord-343791-0vykwml5	253	2	69	69	CD
cord-343791-0vykwml5	253	3	]	]	-RRB-
cord-343791-0vykwml5	254	1	This	this	DT
cord-343791-0vykwml5	254	2	rapid	rapid	JJ
cord-343791-0vykwml5	254	3	induction	induction	NN
cord-343791-0vykwml5	254	4	of	of	IN
cord-343791-0vykwml5	254	5	hemostasis	hemostasis	NN
cord-343791-0vykwml5	254	6	circumvented	circumvent	VBD
cord-343791-0vykwml5	254	7	the	the	DT
cord-343791-0vykwml5	254	8	need	need	NN
cord-343791-0vykwml5	254	9	for	for	IN
cord-343791-0vykwml5	254	10	components	component	NNS
cord-343791-0vykwml5	254	11	of	of	IN
cord-343791-0vykwml5	254	12	the	the	DT
cord-343791-0vykwml5	254	13	clotting	clotting	NN
cord-343791-0vykwml5	254	14	cascade	cascade	NN
cord-343791-0vykwml5	254	15	to	to	TO
cord-343791-0vykwml5	254	16	activate	activate	VB
cord-343791-0vykwml5	254	17	the	the	DT
cord-343791-0vykwml5	254	18	hemostat	hemostat	NN
cord-343791-0vykwml5	254	19	,	,	,
cord-343791-0vykwml5	254	20	it	-PRON-	PRP
cord-343791-0vykwml5	254	21	avoided	avoid	VBD
cord-343791-0vykwml5	254	22	the	the	DT
cord-343791-0vykwml5	254	23	use	use	NN
cord-343791-0vykwml5	254	24	of	of	IN
cord-343791-0vykwml5	254	25	heat	heat	NN
cord-343791-0vykwml5	254	26	or	or	CC
cord-343791-0vykwml5	254	27	pyrogenic	pyrogenic	JJ
cord-343791-0vykwml5	254	28	substances	substance	NNS
cord-343791-0vykwml5	254	29	,	,	,
cord-343791-0vykwml5	254	30	and	and	CC
cord-343791-0vykwml5	254	31	it	-PRON-	PRP
cord-343791-0vykwml5	254	32	was	be	VBD
cord-343791-0vykwml5	254	33	effective	effective	JJ
cord-343791-0vykwml5	254	34	in	in	IN
cord-343791-0vykwml5	254	35	the	the	DT
cord-343791-0vykwml5	254	36	presence	presence	NN
cord-343791-0vykwml5	254	37	of	of	IN
cord-343791-0vykwml5	254	38	anti	anti	JJ
cord-343791-0vykwml5	254	39	-	-	JJ
cord-343791-0vykwml5	254	40	coagulant	coagulant	JJ
cord-343791-0vykwml5	254	41	therapies	therapy	NNS
cord-343791-0vykwml5	254	42	[	[	-LRB-
cord-343791-0vykwml5	254	43	70	70	CD
cord-343791-0vykwml5	254	44	]	]	-RRB-
cord-343791-0vykwml5	254	45	without	without	IN
cord-343791-0vykwml5	254	46	causing	cause	VBG
cord-343791-0vykwml5	254	47	pronounced	pronounce	VBN
cord-343791-0vykwml5	254	48	tissue	tissue	NN
cord-343791-0vykwml5	254	49	responses	response	NNS
cord-343791-0vykwml5	254	50	.	.	.
cord-343791-0vykwml5	255	1	[	[	-LRB-
cord-343791-0vykwml5	255	2	71	71	CD
cord-343791-0vykwml5	255	3	]	]	-RRB-
cord-343791-0vykwml5	256	1	Although	although	IN
cord-343791-0vykwml5	256	2	the	the	DT
cord-343791-0vykwml5	256	3	peptide	peptide	NN
cord-343791-0vykwml5	256	4	is	be	VBZ
cord-343791-0vykwml5	256	5	slightly	slightly	RB
cord-343791-0vykwml5	256	6	acidic	acidic	JJ
cord-343791-0vykwml5	256	7	,	,	,
cord-343791-0vykwml5	256	8	it	-PRON-	PRP
cord-343791-0vykwml5	256	9	did	do	VBD
cord-343791-0vykwml5	256	10	not	not	RB
cord-343791-0vykwml5	256	11	cause	cause	VB
cord-343791-0vykwml5	256	12	significant	significant	JJ
cord-343791-0vykwml5	256	13	inflammation	inflammation	NN
cord-343791-0vykwml5	256	14	in	in	IN
cord-343791-0vykwml5	256	15	any	any	DT
cord-343791-0vykwml5	256	16	animal	animal	NN
cord-343791-0vykwml5	256	17	or	or	CC
cord-343791-0vykwml5	256	18	clinical	clinical	JJ
cord-343791-0vykwml5	256	19	studies	study	NNS
cord-343791-0vykwml5	256	20	,	,	,
cord-343791-0vykwml5	256	21	even	even	RB
cord-343791-0vykwml5	256	22	when	when	WRB
cord-343791-0vykwml5	256	23	applied	apply	VBN
cord-343791-0vykwml5	256	24	to	to	IN
cord-343791-0vykwml5	256	25	the	the	DT
cord-343791-0vykwml5	256	26	brain	brain	NN
cord-343791-0vykwml5	256	27	.	.	.
cord-343791-0vykwml5	257	1	[	[	-LRB-
cord-343791-0vykwml5	257	2	72	72	CD
cord-343791-0vykwml5	257	3	]	]	-RRB-
cord-343791-0vykwml5	257	4	Also	also	RB
cord-343791-0vykwml5	257	5	named	name	VBN
cord-343791-0vykwml5	257	6	TDM-621	tdm-621	XX
cord-343791-0vykwml5	257	7	,	,	,
cord-343791-0vykwml5	257	8	the	the	DT
cord-343791-0vykwml5	257	9	RADA16-I	RADA16-I	NNP
cord-343791-0vykwml5	257	10	peptide	peptide	NN
cord-343791-0vykwml5	257	11	was	be	VBD
cord-343791-0vykwml5	257	12	first	first	RB
cord-343791-0vykwml5	257	13	tested	test	VBN
cord-343791-0vykwml5	257	14	as	as	IN
cord-343791-0vykwml5	257	15	a	a	DT
cord-343791-0vykwml5	257	16	hemostat	hemostat	NN
cord-343791-0vykwml5	257	17	in	in	IN
cord-343791-0vykwml5	257	18	human	human	JJ
cord-343791-0vykwml5	257	19	surgeries	surgery	NNS
cord-343791-0vykwml5	257	20	in	in	IN
cord-343791-0vykwml5	257	21	Japan	Japan	NNP
cord-343791-0vykwml5	257	22	during	during	IN
cord-343791-0vykwml5	257	23	cardiovascular	cardiovascular	JJ
cord-343791-0vykwml5	257	24	procedures	procedure	NNS
cord-343791-0vykwml5	257	25	,	,	,
cord-343791-0vykwml5	257	26	[	[	-LRB-
cord-343791-0vykwml5	257	27	73	73	CD
cord-343791-0vykwml5	257	28	]	]	-RRB-
cord-343791-0vykwml5	257	29	and	and	CC
cord-343791-0vykwml5	257	30	later	later	RB
cord-343791-0vykwml5	257	31	during	during	IN
cord-343791-0vykwml5	257	32	endoscopic	endoscopic	JJ
cord-343791-0vykwml5	257	33	mucosal	mucosal	JJ
cord-343791-0vykwml5	257	34	resection	resection	NN
cord-343791-0vykwml5	257	35	,	,	,
cord-343791-0vykwml5	257	36	[	[	-LRB-
cord-343791-0vykwml5	257	37	74	74	CD
cord-343791-0vykwml5	257	38	]	]	-RRB-
cord-343791-0vykwml5	257	39	with	with	IN
cord-343791-0vykwml5	257	40	no	no	DT
cord-343791-0vykwml5	257	41	treatment	treatment	NN
cord-343791-0vykwml5	257	42	-	-	HYPH
cord-343791-0vykwml5	257	43	related	relate	VBN
cord-343791-0vykwml5	257	44	adverse	adverse	JJ
cord-343791-0vykwml5	257	45	events	event	NNS
cord-343791-0vykwml5	257	46	in	in	IN
cord-343791-0vykwml5	257	47	either	either	DT
cord-343791-0vykwml5	257	48	trial	trial	NN
cord-343791-0vykwml5	257	49	.	.	.
cord-343791-0vykwml5	258	1	Purastat	Purastat	NNP
cord-343791-0vykwml5	258	2	is	be	VBZ
cord-343791-0vykwml5	258	3	limited	limit	VBN
cord-343791-0vykwml5	258	4	to	to	IN
cord-343791-0vykwml5	258	5	relatively	relatively	RB
cord-343791-0vykwml5	258	6	low	low	JJ
cord-343791-0vykwml5	258	7	pressure	pressure	NN
cord-343791-0vykwml5	258	8	hemorrhages	hemorrhage	NNS
cord-343791-0vykwml5	258	9	in	in	IN
cord-343791-0vykwml5	258	10	comparison	comparison	NN
cord-343791-0vykwml5	258	11	to	to	IN
cord-343791-0vykwml5	258	12	major	major	JJ
cord-343791-0vykwml5	258	13	arterial	arterial	JJ
cord-343791-0vykwml5	258	14	injuries	injury	NNS
cord-343791-0vykwml5	258	15	,	,	,
cord-343791-0vykwml5	258	16	[	[	-LRB-
cord-343791-0vykwml5	258	17	75	75	CD
cord-343791-0vykwml5	258	18	]	]	-RRB-
cord-343791-0vykwml5	258	19	but	but	CC
cord-343791-0vykwml5	258	20	has	have	VBZ
cord-343791-0vykwml5	258	21	general	general	JJ
cord-343791-0vykwml5	258	22	utility	utility	NN
cord-343791-0vykwml5	258	23	as	as	IN
cord-343791-0vykwml5	258	24	a	a	DT
cord-343791-0vykwml5	258	25	versatile	versatile	JJ
cord-343791-0vykwml5	258	26	,	,	,
cord-343791-0vykwml5	258	27	biodegradable	biodegradable	JJ
cord-343791-0vykwml5	258	28	hemostat	hemostat	NN
cord-343791-0vykwml5	258	29	.	.	.
cord-343791-0vykwml5	259	1	Clinical	clinical	JJ
cord-343791-0vykwml5	259	2	trials	trial	NNS
cord-343791-0vykwml5	259	3	to	to	TO
cord-343791-0vykwml5	259	4	monitor	monitor	VB
cord-343791-0vykwml5	259	5	the	the	DT
cord-343791-0vykwml5	259	6	post	post	JJ
cord-343791-0vykwml5	259	7	-	-	JJ
cord-343791-0vykwml5	259	8	market	market	JJ
cord-343791-0vykwml5	259	9	performance	performance	NN
cord-343791-0vykwml5	259	10	of	of	IN
cord-343791-0vykwml5	259	11	Purastat	Purastat	NNP
cord-343791-0vykwml5	259	12	for	for	IN
cord-343791-0vykwml5	259	13	vascular	vascular	JJ
cord-343791-0vykwml5	259	14	surgery	surgery	NN
cord-343791-0vykwml5	259	15	(	(	-LRB-
cord-343791-0vykwml5	259	16	NCT03103282	NCT03103282	NNP
cord-343791-0vykwml5	259	17	)	)	-RRB-
cord-343791-0vykwml5	259	18	,	,	,
cord-343791-0vykwml5	259	19	and	and	CC
cord-343791-0vykwml5	259	20	to	to	TO
cord-343791-0vykwml5	259	21	test	test	VB
cord-343791-0vykwml5	259	22	the	the	DT
cord-343791-0vykwml5	259	23	use	use	NN
cord-343791-0vykwml5	259	24	of	of	IN
cord-343791-0vykwml5	259	25	Purastat	Purastat	NNP
cord-343791-0vykwml5	259	26	during	during	IN
cord-343791-0vykwml5	259	27	endoscopic	endoscopic	JJ
cord-343791-0vykwml5	259	28	submucosal	submucosal	NN
cord-343791-0vykwml5	259	29	dissection	dissection	NN
cord-343791-0vykwml5	259	30	are	be	VBP
cord-343791-0vykwml5	259	31	scheduled	schedule	VBN
cord-343791-0vykwml5	259	32	to	to	TO
cord-343791-0vykwml5	259	33	begin	begin	VB
cord-343791-0vykwml5	259	34	soon	soon	RB
cord-343791-0vykwml5	259	35	(	(	-LRB-
cord-343791-0vykwml5	259	36	NCT02833558	nct02833558	NN
cord-343791-0vykwml5	259	37	)	)	-RRB-
cord-343791-0vykwml5	259	38	.	.	.
cord-343791-0vykwml5	260	1	Purastat	Purastat	NNP
cord-343791-0vykwml5	260	2	has	have	VBZ
cord-343791-0vykwml5	260	3	already	already	RB
cord-343791-0vykwml5	260	4	achieved	achieve	VBN
cord-343791-0vykwml5	260	5	CE	CE	NNP
cord-343791-0vykwml5	260	6	marking	mark	VBG
cord-343791-0vykwml5	260	7	in	in	IN
cord-343791-0vykwml5	260	8	Europe	Europe	NNP
cord-343791-0vykwml5	260	9	and	and	CC
cord-343791-0vykwml5	260	10	has	have	VBZ
cord-343791-0vykwml5	260	11	currently	currently	RB
cord-343791-0vykwml5	260	12	received	receive	VBN
cord-343791-0vykwml5	260	13	medical	medical	JJ
cord-343791-0vykwml5	260	14	device	device	NN
cord-343791-0vykwml5	260	15	product	product	NN
cord-343791-0vykwml5	260	16	registration	registration	NN
cord-343791-0vykwml5	260	17	approval	approval	NN
cord-343791-0vykwml5	260	18	in	in	IN
cord-343791-0vykwml5	260	19	a	a	DT
cord-343791-0vykwml5	260	20	number	number	NN
cord-343791-0vykwml5	260	21	of	of	IN
cord-343791-0vykwml5	260	22	countries	country	NNS
cord-343791-0vykwml5	260	23	including	include	VBG
cord-343791-0vykwml5	260	24	Thailand	Thailand	NNP
cord-343791-0vykwml5	260	25	,	,	,
cord-343791-0vykwml5	260	26	Mexico	Mexico	NNP
cord-343791-0vykwml5	260	27	,	,	,
cord-343791-0vykwml5	260	28	and	and	CC
cord-343791-0vykwml5	260	29	Indonesia	Indonesia	NNP
cord-343791-0vykwml5	260	30	,	,	,
cord-343791-0vykwml5	260	31	and	and	CC
cord-343791-0vykwml5	260	32	Australia	Australia	NNP
cord-343791-0vykwml5	260	33	.	.	.
cord-343791-0vykwml5	261	1	Initial	initial	JJ
cord-343791-0vykwml5	261	2	studies	study	NNS
cord-343791-0vykwml5	261	3	of	of	IN
cord-343791-0vykwml5	261	4	the	the	DT
cord-343791-0vykwml5	261	5	RADA	RADA	NNP
cord-343791-0vykwml5	261	6	family	family	NN
cord-343791-0vykwml5	261	7	of	of	IN
cord-343791-0vykwml5	261	8	peptides	peptide	NNS
cord-343791-0vykwml5	261	9	inspired	inspire	VBD
cord-343791-0vykwml5	261	10	the	the	DT
cord-343791-0vykwml5	261	11	development	development	NN
cord-343791-0vykwml5	261	12	of	of	IN
cord-343791-0vykwml5	261	13	general	general	JJ
cord-343791-0vykwml5	261	14	design	design	NN
cord-343791-0vykwml5	261	15	principles	principle	NNS
cord-343791-0vykwml5	261	16	for	for	IN
cord-343791-0vykwml5	261	17	forming	form	VBG
cord-343791-0vykwml5	261	18	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	261	19	,	,	,
cord-343791-0vykwml5	261	20	during	during	IN
cord-343791-0vykwml5	261	21	which	which	WDT
cord-343791-0vykwml5	261	22	other	other	JJ
cord-343791-0vykwml5	261	23	peptides	peptide	NNS
cord-343791-0vykwml5	261	24	were	be	VBD
cord-343791-0vykwml5	261	25	shown	show	VBN
cord-343791-0vykwml5	261	26	to	to	TO
cord-343791-0vykwml5	261	27	have	have	VB
cord-343791-0vykwml5	261	28	similar	similar	JJ
cord-343791-0vykwml5	261	29	self	self	NN
cord-343791-0vykwml5	261	30	-	-	HYPH
cord-343791-0vykwml5	261	31	assembling	assemble	VBG
cord-343791-0vykwml5	261	32	properties	property	NNS
cord-343791-0vykwml5	261	33	.	.	.
cord-343791-0vykwml5	262	1	Notably	notably	RB
cord-343791-0vykwml5	262	2	,	,	,
cord-343791-0vykwml5	262	3	peptide	peptide	NN
cord-343791-0vykwml5	262	4	P	p	NN
cord-343791-0vykwml5	262	5	11	11	CD
cord-343791-0vykwml5	262	6	,	,	,
cord-343791-0vykwml5	262	7	developed	develop	VBN
cord-343791-0vykwml5	262	8	by	by	IN
cord-343791-0vykwml5	262	9	Aggeli	Aggeli	NNP
cord-343791-0vykwml5	262	10	et	et	NNP
cord-343791-0vykwml5	262	11	al	al	NNP
cord-343791-0vykwml5	262	12	.	.	NNP
cord-343791-0vykwml5	262	13	,	,	,
cord-343791-0vykwml5	262	14	would	would	MD
cord-343791-0vykwml5	262	15	eventually	eventually	RB
cord-343791-0vykwml5	262	16	lead	lead	VB
cord-343791-0vykwml5	262	17	to	to	IN
cord-343791-0vykwml5	262	18	the	the	DT
cord-343791-0vykwml5	262	19	development	development	NN
cord-343791-0vykwml5	262	20	of	of	IN
cord-343791-0vykwml5	262	21	the	the	DT
cord-343791-0vykwml5	262	22	enamel	enamel	JJ
cord-343791-0vykwml5	262	23	regeneration	regeneration	NN
cord-343791-0vykwml5	262	24	product	product	NN
cord-343791-0vykwml5	262	25	Curodont	Curodont	NNP
cord-343791-0vykwml5	262	26	.	.	.
cord-343791-0vykwml5	263	1	The	the	DT
cord-343791-0vykwml5	263	2	first	first	JJ
cord-343791-0vykwml5	263	3	sequence	sequence	NN
cord-343791-0vykwml5	263	4	designed	design	VBN
cord-343791-0vykwml5	263	5	by	by	IN
cord-343791-0vykwml5	263	6	Aggeli	Aggeli	NNP
cord-343791-0vykwml5	263	7	et	et	NNP
cord-343791-0vykwml5	263	8	al	al	NNP
cord-343791-0vykwml5	263	9	.	.	.
cord-343791-0vykwml5	264	1	in	in	IN
cord-343791-0vykwml5	264	2	1997	1997	CD
cord-343791-0vykwml5	264	3	was	be	VBD
cord-343791-0vykwml5	264	4	a	a	DT
cord-343791-0vykwml5	264	5	mimic	mimic	NN
cord-343791-0vykwml5	264	6	of	of	IN
cord-343791-0vykwml5	264	7	a	a	DT
cord-343791-0vykwml5	264	8	β	β	NN
cord-343791-0vykwml5	264	9	-	-	HYPH
cord-343791-0vykwml5	264	10	sheet	sheet	NN
cord-343791-0vykwml5	264	11	transmembrane	transmembrane	NN
cord-343791-0vykwml5	264	12	protein	protein	NN
cord-343791-0vykwml5	264	13	.	.	.
cord-343791-0vykwml5	265	1	[	[	-LRB-
cord-343791-0vykwml5	265	2	76	76	CD
cord-343791-0vykwml5	265	3	,	,	,
cord-343791-0vykwml5	265	4	77	77	CD
cord-343791-0vykwml5	265	5	]	]	-RRB-
cord-343791-0vykwml5	266	1	This	this	DT
cord-343791-0vykwml5	266	2	peptide	peptide	NN
cord-343791-0vykwml5	266	3	was	be	VBD
cord-343791-0vykwml5	266	4	designed	design	VBN
cord-343791-0vykwml5	266	5	de	de	FW
cord-343791-0vykwml5	266	6	novo	novo	NNP
cord-343791-0vykwml5	266	7	based	base	VBN
cord-343791-0vykwml5	266	8	on	on	IN
cord-343791-0vykwml5	266	9	patterns	pattern	NNS
cord-343791-0vykwml5	266	10	found	find	VBN
cord-343791-0vykwml5	266	11	in	in	IN
cord-343791-0vykwml5	266	12	the	the	DT
cord-343791-0vykwml5	266	13	transmembrane	transmembrane	NN
cord-343791-0vykwml5	266	14	protein	protein	NN
cord-343791-0vykwml5	266	15	and	and	CC
cord-343791-0vykwml5	266	16	was	be	VBD
cord-343791-0vykwml5	266	17	shown	show	VBN
cord-343791-0vykwml5	266	18	to	to	TO
cord-343791-0vykwml5	266	19	form	form	VB
cord-343791-0vykwml5	266	20	high	high	JJ
cord-343791-0vykwml5	266	21	aspect	aspect	NN
cord-343791-0vykwml5	266	22	-	-	HYPH
cord-343791-0vykwml5	266	23	ratio	ratio	NN
cord-343791-0vykwml5	266	24	fibrils	fibril	NNS
cord-343791-0vykwml5	266	25	that	that	WDT
cord-343791-0vykwml5	266	26	tangled	tangle	VBD
cord-343791-0vykwml5	266	27	to	to	TO
cord-343791-0vykwml5	266	28	form	form	VB
cord-343791-0vykwml5	266	29	hydrogels	hydrogel	NNS
cord-343791-0vykwml5	266	30	independently	independently	RB
cord-343791-0vykwml5	266	31	of	of	IN
cord-343791-0vykwml5	266	32	pH	ph	NN
cord-343791-0vykwml5	266	33	in	in	IN
cord-343791-0vykwml5	266	34	a	a	DT
cord-343791-0vykwml5	266	35	manner	manner	NN
cord-343791-0vykwml5	266	36	similar	similar	JJ
cord-343791-0vykwml5	266	37	to	to	IN
cord-343791-0vykwml5	266	38	the	the	DT
cord-343791-0vykwml5	266	39	protein	protein	NN
cord-343791-0vykwml5	266	40	-	-	HYPH
cord-343791-0vykwml5	266	41	inspired	inspire	VBN
cord-343791-0vykwml5	266	42	peptide	peptide	NN
cord-343791-0vykwml5	266	43	on	on	IN
cord-343791-0vykwml5	266	44	which	which	WDT
cord-343791-0vykwml5	266	45	it	-PRON-	PRP
cord-343791-0vykwml5	266	46	was	be	VBD
cord-343791-0vykwml5	266	47	based	base	VBN
cord-343791-0vykwml5	266	48	.	.	.
cord-343791-0vykwml5	267	1	[	[	-LRB-
cord-343791-0vykwml5	267	2	77	77	CD
cord-343791-0vykwml5	267	3	]	]	-RRB-
cord-343791-0vykwml5	268	1	Currently	currently	RB
cord-343791-0vykwml5	268	2	,	,	,
cord-343791-0vykwml5	268	3	this	this	DT
cord-343791-0vykwml5	268	4	peptide	peptide	NN
cord-343791-0vykwml5	268	5	is	be	VBZ
cord-343791-0vykwml5	268	6	on	on	IN
cord-343791-0vykwml5	268	7	the	the	DT
cord-343791-0vykwml5	268	8	market	market	NN
cord-343791-0vykwml5	268	9	in	in	IN
cord-343791-0vykwml5	268	10	the	the	DT
cord-343791-0vykwml5	268	11	European	European	NNP
cord-343791-0vykwml5	268	12	Union	Union	NNP
cord-343791-0vykwml5	268	13	(	(	-LRB-
cord-343791-0vykwml5	268	14	EU	EU	NNP
cord-343791-0vykwml5	268	15	)	)	-RRB-
cord-343791-0vykwml5	268	16	and	and	CC
cord-343791-0vykwml5	268	17	Switzerland	Switzerland	NNP
cord-343791-0vykwml5	268	18	in	in	IN
cord-343791-0vykwml5	268	19	the	the	DT
cord-343791-0vykwml5	268	20	form	form	NN
cord-343791-0vykwml5	268	21	of	of	IN
cord-343791-0vykwml5	268	22	a	a	DT
cord-343791-0vykwml5	268	23	treatment	treatment	NN
cord-343791-0vykwml5	268	24	for	for	IN
cord-343791-0vykwml5	268	25	dental	dental	JJ
cord-343791-0vykwml5	268	26	enamel	enamel	JJ
cord-343791-0vykwml5	268	27	caries	caries	NN
cord-343791-0vykwml5	268	28	,	,	,
cord-343791-0vykwml5	268	29	and	and	CC
cord-343791-0vykwml5	268	30	it	-PRON-	PRP
cord-343791-0vykwml5	268	31	functions	function	VBZ
cord-343791-0vykwml5	268	32	by	by	IN
cord-343791-0vykwml5	268	33	creating	create	VBG
cord-343791-0vykwml5	268	34	a	a	DT
cord-343791-0vykwml5	268	35	local	local	JJ
cord-343791-0vykwml5	268	36	environment	environment	NN
cord-343791-0vykwml5	268	37	that	that	WDT
cord-343791-0vykwml5	268	38	enhances	enhance	VBZ
cord-343791-0vykwml5	268	39	enamel	enamel	JJ
cord-343791-0vykwml5	268	40	mineralization	mineralization	NN
cord-343791-0vykwml5	268	41	.	.	.
cord-343791-0vykwml5	269	1	[	[	-LRB-
cord-343791-0vykwml5	269	2	77	77	CD
cord-343791-0vykwml5	269	3	]	]	-RRB-
cord-343791-0vykwml5	269	4	Upon	upon	IN
cord-343791-0vykwml5	269	5	injection	injection	NN
cord-343791-0vykwml5	269	6	,	,	,
cord-343791-0vykwml5	269	7	monomeric	monomeric	JJ
cord-343791-0vykwml5	269	8	peptides	peptide	NNS
cord-343791-0vykwml5	269	9	assemble	assemble	VBP
cord-343791-0vykwml5	269	10	into	into	IN
cord-343791-0vykwml5	269	11	nanotapes	nanotape	NNS
cord-343791-0vykwml5	269	12	to	to	TO
cord-343791-0vykwml5	269	13	create	create	VB
cord-343791-0vykwml5	269	14	a	a	DT
cord-343791-0vykwml5	269	15	3D	3d	JJ
cord-343791-0vykwml5	269	16	matrix	matrix	NN
cord-343791-0vykwml5	269	17	that	that	IN
cord-343791-0vykwml5	269	18	in	in	IN
cord-343791-0vykwml5	269	19	some	some	DT
cord-343791-0vykwml5	269	20	respects	respect	NNS
cord-343791-0vykwml5	269	21	resembles	resemble	VBZ
cord-343791-0vykwml5	269	22	the	the	DT
cord-343791-0vykwml5	269	23	matrix	matrix	NN
cord-343791-0vykwml5	269	24	environment	environment	NN
cord-343791-0vykwml5	269	25	necessary	necessary	JJ
cord-343791-0vykwml5	269	26	for	for	IN
cord-343791-0vykwml5	269	27	enamel	enamel	JJ
cord-343791-0vykwml5	269	28	deposition	deposition	NN
cord-343791-0vykwml5	269	29	.	.	.
cord-343791-0vykwml5	270	1	[	[	-LRB-
cord-343791-0vykwml5	270	2	78	78	CD
cord-343791-0vykwml5	270	3	]	]	-RRB-
cord-343791-0vykwml5	271	1	A	a	DT
cord-343791-0vykwml5	271	2	major	major	JJ
cord-343791-0vykwml5	271	3	design	design	NN
cord-343791-0vykwml5	271	4	improvement	improvement	NN
cord-343791-0vykwml5	271	5	preceding	precede	VBG
cord-343791-0vykwml5	271	6	the	the	DT
cord-343791-0vykwml5	271	7	final	final	JJ
cord-343791-0vykwml5	271	8	Curodont	Curodont	NNP
cord-343791-0vykwml5	271	9	peptide	peptide	JJ
cord-343791-0vykwml5	271	10	sequence	sequence	NN
cord-343791-0vykwml5	271	11	was	be	VBD
cord-343791-0vykwml5	271	12	the	the	DT
cord-343791-0vykwml5	271	13	introduction	introduction	NN
cord-343791-0vykwml5	271	14	of	of	IN
cord-343791-0vykwml5	271	15	pH	ph	NN
cord-343791-0vykwml5	271	16	-	-	NN
cord-343791-0vykwml5	271	17	sensitivity	sensitivity	NN
cord-343791-0vykwml5	271	18	.	.	.
cord-343791-0vykwml5	272	1	In	in	IN
cord-343791-0vykwml5	272	2	2003	2003	CD
cord-343791-0vykwml5	272	3	,	,	,
cord-343791-0vykwml5	272	4	Aggeli	Aggeli	NNP
cord-343791-0vykwml5	272	5	et	et	NNP
cord-343791-0vykwml5	272	6	al	al	NNP
cord-343791-0vykwml5	272	7	.	.	.
cord-343791-0vykwml5	273	1	rationally	rationally	RB
cord-343791-0vykwml5	273	2	modified	modify	VBD
cord-343791-0vykwml5	273	3	the	the	DT
cord-343791-0vykwml5	273	4	original	original	JJ
cord-343791-0vykwml5	273	5	peptide	peptide	NN
cord-343791-0vykwml5	273	6	sequence	sequence	NN
cord-343791-0vykwml5	273	7	so	so	IN
cord-343791-0vykwml5	273	8	that	that	IN
cord-343791-0vykwml5	273	9	it	-PRON-	PRP
cord-343791-0vykwml5	273	10	was	be	VBD
cord-343791-0vykwml5	273	11	negatively	negatively	RB
cord-343791-0vykwml5	273	12	charged	charge	VBN
cord-343791-0vykwml5	273	13	at	at	IN
cord-343791-0vykwml5	273	14	pH	pH	NNP
cord-343791-0vykwml5	274	1	>	>	XX
cord-343791-0vykwml5	274	2	8	8	CD
cord-343791-0vykwml5	274	3	,	,	,
cord-343791-0vykwml5	274	4	thus	thus	RB
cord-343791-0vykwml5	274	5	creating	create	VBG
cord-343791-0vykwml5	274	6	electrostatic	electrostatic	JJ
cord-343791-0vykwml5	274	7	repulsion	repulsion	NN
cord-343791-0vykwml5	274	8	and	and	CC
cord-343791-0vykwml5	274	9	allowing	allow	VBG
cord-343791-0vykwml5	274	10	the	the	DT
cord-343791-0vykwml5	274	11	peptides	peptide	NNS
cord-343791-0vykwml5	274	12	to	to	TO
cord-343791-0vykwml5	274	13	remain	remain	VB
cord-343791-0vykwml5	274	14	in	in	IN
cord-343791-0vykwml5	274	15	a	a	DT
cord-343791-0vykwml5	274	16	monomeric	monomeric	JJ
cord-343791-0vykwml5	274	17	,	,	,
cord-343791-0vykwml5	274	18	unassembled	unassembled	JJ
cord-343791-0vykwml5	274	19	state	state	NN
cord-343791-0vykwml5	274	20	.	.	.
cord-343791-0vykwml5	275	1	[	[	-LRB-
cord-343791-0vykwml5	275	2	78	78	CD
cord-343791-0vykwml5	275	3	]	]	-RRB-
cord-343791-0vykwml5	275	4	Upon	upon	IN
cord-343791-0vykwml5	275	5	switching	switch	VBG
cord-343791-0vykwml5	275	6	to	to	IN
cord-343791-0vykwml5	275	7	more	more	RBR
cord-343791-0vykwml5	275	8	acidic	acidic	JJ
cord-343791-0vykwml5	275	9	pH	ph	NN
cord-343791-0vykwml5	275	10	,	,	,
cord-343791-0vykwml5	275	11	however	however	RB
cord-343791-0vykwml5	275	12	,	,	,
cord-343791-0vykwml5	275	13	the	the	DT
cord-343791-0vykwml5	275	14	acidic	acidic	JJ
cord-343791-0vykwml5	275	15	residues	residue	NNS
cord-343791-0vykwml5	275	16	became	become	VBD
cord-343791-0vykwml5	275	17	protonated	protonated	JJ
cord-343791-0vykwml5	275	18	and	and	CC
cord-343791-0vykwml5	275	19	monomers	monomer	NNS
cord-343791-0vykwml5	275	20	assembled	assemble	VBN
cord-343791-0vykwml5	275	21	in	in	RP
cord-343791-0vykwml5	275	22	to	to	IN
cord-343791-0vykwml5	275	23	β	β	NN
cord-343791-0vykwml5	275	24	-	-	HYPH
cord-343791-0vykwml5	275	25	sheet	sheet	NN
cord-343791-0vykwml5	275	26	tapes	tape	NNS
cord-343791-0vykwml5	275	27	.	.	.
cord-343791-0vykwml5	276	1	[	[	-LRB-
cord-343791-0vykwml5	276	2	79	79	CD
cord-343791-0vykwml5	276	3	]	]	-RRB-
cord-343791-0vykwml5	277	1	This	this	DT
cord-343791-0vykwml5	277	2	pH	ph	NN
cord-343791-0vykwml5	277	3	-	-	HYPH
cord-343791-0vykwml5	277	4	sensitivity	sensitivity	NN
cord-343791-0vykwml5	277	5	allows	allow	VBZ
cord-343791-0vykwml5	277	6	for	for	IN
cord-343791-0vykwml5	277	7	in	in	IN
cord-343791-0vykwml5	277	8	situ	situ	JJ
cord-343791-0vykwml5	277	9	assembly	assembly	NN
cord-343791-0vykwml5	277	10	of	of	IN
cord-343791-0vykwml5	277	11	peptides	peptide	NNS
cord-343791-0vykwml5	277	12	into	into	IN
cord-343791-0vykwml5	277	13	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	277	14	,	,	,
cord-343791-0vykwml5	277	15	which	which	WDT
cord-343791-0vykwml5	277	16	is	be	VBZ
cord-343791-0vykwml5	277	17	hypothesized	hypothesize	VBN
cord-343791-0vykwml5	277	18	to	to	TO
cord-343791-0vykwml5	277	19	improve	improve	VB
cord-343791-0vykwml5	277	20	the	the	DT
cord-343791-0vykwml5	277	21	efficacy	efficacy	NN
cord-343791-0vykwml5	277	22	of	of	IN
cord-343791-0vykwml5	277	23	Curodont	Curodont	NNP
cord-343791-0vykwml5	277	24	as	as	IN
cord-343791-0vykwml5	277	25	the	the	DT
cord-343791-0vykwml5	277	26	material	material	NN
cord-343791-0vykwml5	277	27	is	be	VBZ
cord-343791-0vykwml5	277	28	able	able	JJ
cord-343791-0vykwml5	277	29	to	to	TO
cord-343791-0vykwml5	277	30	completely	completely	RB
cord-343791-0vykwml5	277	31	fill	fill	VB
cord-343791-0vykwml5	277	32	demineralized	demineralize	VBN
cord-343791-0vykwml5	277	33	defects	defect	NNS
cord-343791-0vykwml5	277	34	of	of	IN
cord-343791-0vykwml5	277	35	varying	vary	VBG
cord-343791-0vykwml5	277	36	shapes	shape	NNS
cord-343791-0vykwml5	277	37	and	and	CC
cord-343791-0vykwml5	277	38	sizes	size	NNS
cord-343791-0vykwml5	277	39	.	.	.
cord-343791-0vykwml5	278	1	This	this	DT
cord-343791-0vykwml5	278	2	pH	ph	JJ
cord-343791-0vykwml5	278	3	-	-	HYPH
cord-343791-0vykwml5	278	4	sensitive	sensitive	JJ
cord-343791-0vykwml5	278	5	assembly	assembly	NN
cord-343791-0vykwml5	278	6	was	be	VBD
cord-343791-0vykwml5	278	7	specifically	specifically	RB
cord-343791-0vykwml5	278	8	explored	explore	VBN
cord-343791-0vykwml5	278	9	in	in	IN
cord-343791-0vykwml5	278	10	the	the	DT
cord-343791-0vykwml5	278	11	context	context	NN
cord-343791-0vykwml5	278	12	of	of	IN
cord-343791-0vykwml5	278	13	enamel	enamel	JJ
cord-343791-0vykwml5	278	14	remineralization	remineralization	NN
cord-343791-0vykwml5	278	15	in	in	IN
cord-343791-0vykwml5	278	16	2007	2007	CD
cord-343791-0vykwml5	278	17	,	,	,
cord-343791-0vykwml5	278	18	where	where	WRB
cord-343791-0vykwml5	278	19	simulated	simulate	VBN
cord-343791-0vykwml5	278	20	intraoral	intraoral	JJ
cord-343791-0vykwml5	278	21	conditions	condition	NNS
cord-343791-0vykwml5	278	22	were	be	VBD
cord-343791-0vykwml5	278	23	employed	employ	VBN
cord-343791-0vykwml5	278	24	to	to	TO
cord-343791-0vykwml5	278	25	assess	assess	VB
cord-343791-0vykwml5	278	26	the	the	DT
cord-343791-0vykwml5	278	27	performance	performance	NN
cord-343791-0vykwml5	278	28	of	of	IN
cord-343791-0vykwml5	278	29	self	self	NN
cord-343791-0vykwml5	278	30	-	-	HYPH
cord-343791-0vykwml5	278	31	assembled	assemble	VBN
cord-343791-0vykwml5	278	32	scaffolds	scaffold	NNS
cord-343791-0vykwml5	278	33	which	which	WDT
cord-343791-0vykwml5	278	34	were	be	VBD
cord-343791-0vykwml5	278	35	administered	administer	VBN
cord-343791-0vykwml5	278	36	in	in	IN
cord-343791-0vykwml5	278	37	a	a	DT
cord-343791-0vykwml5	278	38	basic	basic	JJ
cord-343791-0vykwml5	278	39	solution	solution	NN
cord-343791-0vykwml5	278	40	,	,	,
cord-343791-0vykwml5	278	41	allowed	allow	VBN
cord-343791-0vykwml5	278	42	to	to	TO
cord-343791-0vykwml5	278	43	fibriliize	fibriliize	VB
cord-343791-0vykwml5	278	44	,	,	,
cord-343791-0vykwml5	278	45	and	and	CC
cord-343791-0vykwml5	278	46	then	then	RB
cord-343791-0vykwml5	278	47	incubated	incubate	VBN
cord-343791-0vykwml5	278	48	under	under	IN
cord-343791-0vykwml5	278	49	cyclic	cyclic	JJ
cord-343791-0vykwml5	278	50	pH.	ph.	NN
cord-343791-0vykwml5	278	51	[	[	-LRB-
cord-343791-0vykwml5	278	52	78	78	CD
cord-343791-0vykwml5	278	53	]	]	-RRB-
cord-343791-0vykwml5	279	1	These	these	DT
cord-343791-0vykwml5	279	2	studies	study	NNS
cord-343791-0vykwml5	279	3	were	be	VBD
cord-343791-0vykwml5	279	4	completed	complete	VBN
cord-343791-0vykwml5	279	5	on	on	IN
cord-343791-0vykwml5	279	6	enamel	enamel	JJ
cord-343791-0vykwml5	279	7	lesions	lesion	NNS
cord-343791-0vykwml5	279	8	formed	form	VBN
cord-343791-0vykwml5	279	9	on	on	IN
cord-343791-0vykwml5	279	10	extracted	extract	VBN
cord-343791-0vykwml5	279	11	human	human	JJ
cord-343791-0vykwml5	279	12	teeth	tooth	NNS
cord-343791-0vykwml5	279	13	and	and	CC
cord-343791-0vykwml5	279	14	indicated	indicate	VBD
cord-343791-0vykwml5	279	15	that	that	IN
cord-343791-0vykwml5	279	16	the	the	DT
cord-343791-0vykwml5	279	17	P	p	NN
cord-343791-0vykwml5	279	18	11	11	CD
cord-343791-0vykwml5	279	19	scaffold	scaffold	NN
cord-343791-0vykwml5	279	20	caused	cause	VBD
cord-343791-0vykwml5	279	21	hydroxyapatite	hydroxyapatite	JJ
cord-343791-0vykwml5	279	22	mineralization	mineralization	NN
cord-343791-0vykwml5	279	23	where	where	WRB
cord-343791-0vykwml5	279	24	the	the	DT
cord-343791-0vykwml5	279	25	peptide	peptide	NN
cord-343791-0vykwml5	279	26	solution	solution	NN
cord-343791-0vykwml5	279	27	was	be	VBD
cord-343791-0vykwml5	279	28	applied	apply	VBN
cord-343791-0vykwml5	279	29	.	.	.
cord-343791-0vykwml5	280	1	[	[	-LRB-
cord-343791-0vykwml5	280	2	78	78	CD
cord-343791-0vykwml5	280	3	]	]	-RRB-
cord-343791-0vykwml5	281	1	Thus	thus	RB
cord-343791-0vykwml5	281	2	,	,	,
cord-343791-0vykwml5	281	3	positive	positive	JJ
cord-343791-0vykwml5	281	4	and	and	CC
cord-343791-0vykwml5	281	5	significant	significant	JJ
cord-343791-0vykwml5	281	6	results	result	NNS
cord-343791-0vykwml5	281	7	were	be	VBD
cord-343791-0vykwml5	281	8	obtained	obtain	VBN
cord-343791-0vykwml5	281	9	without	without	IN
cord-343791-0vykwml5	281	10	the	the	DT
cord-343791-0vykwml5	281	11	need	need	NN
cord-343791-0vykwml5	281	12	for	for	IN
cord-343791-0vykwml5	281	13	specialized	specialized	JJ
cord-343791-0vykwml5	281	14	application	application	NN
cord-343791-0vykwml5	281	15	methods	method	NNS
cord-343791-0vykwml5	281	16	or	or	CC
cord-343791-0vykwml5	281	17	a	a	DT
cord-343791-0vykwml5	281	18	poorly	poorly	RB
cord-343791-0vykwml5	281	19	translatable	translatable	JJ
cord-343791-0vykwml5	281	20	animal	animal	NN
cord-343791-0vykwml5	281	21	model	model	NN
cord-343791-0vykwml5	281	22	,	,	,
cord-343791-0vykwml5	281	23	a	a	DT
cord-343791-0vykwml5	281	24	significant	significant	JJ
cord-343791-0vykwml5	281	25	advantage	advantage	NN
cord-343791-0vykwml5	281	26	for	for	IN
cord-343791-0vykwml5	281	27	the	the	DT
cord-343791-0vykwml5	281	28	development	development	NN
cord-343791-0vykwml5	281	29	of	of	IN
cord-343791-0vykwml5	281	30	polypeptide	polypeptide	NN
cord-343791-0vykwml5	281	31	biomaterials	biomaterial	NNS
cord-343791-0vykwml5	281	32	toward	toward	IN
cord-343791-0vykwml5	281	33	dental	dental	JJ
cord-343791-0vykwml5	281	34	applications	application	NNS
cord-343791-0vykwml5	281	35	.	.	.
cord-343791-0vykwml5	282	1	After	after	IN
cord-343791-0vykwml5	282	2	the	the	DT
cord-343791-0vykwml5	282	3	enamel	enamel	JJ
cord-343791-0vykwml5	282	4	restorative	restorative	JJ
cord-343791-0vykwml5	282	5	properties	property	NNS
cord-343791-0vykwml5	282	6	of	of	IN
cord-343791-0vykwml5	282	7	P	p	NN
cord-343791-0vykwml5	282	8	11	11	CD
cord-343791-0vykwml5	282	9	were	be	VBD
cord-343791-0vykwml5	282	10	developed	develop	VBN
cord-343791-0vykwml5	282	11	in	in	IN
cord-343791-0vykwml5	282	12	preclinical	preclinical	JJ
cord-343791-0vykwml5	282	13	models	model	NNS
cord-343791-0vykwml5	282	14	,	,	,
cord-343791-0vykwml5	282	15	Credentis	Credentis	NNP
cord-343791-0vykwml5	282	16	was	be	VBD
cord-343791-0vykwml5	282	17	founded	found	VBN
cord-343791-0vykwml5	282	18	in	in	IN
cord-343791-0vykwml5	282	19	2010	2010	CD
cord-343791-0vykwml5	282	20	,	,	,
cord-343791-0vykwml5	282	21	Curodont	Curodont	NNP
cord-343791-0vykwml5	282	22	was	be	VBD
cord-343791-0vykwml5	282	23	launched	launch	VBN
cord-343791-0vykwml5	282	24	as	as	IN
cord-343791-0vykwml5	282	25	the	the	DT
cord-343791-0vykwml5	282	26	company	company	NN
cord-343791-0vykwml5	282	27	's	's	POS
cord-343791-0vykwml5	282	28	first	first	JJ
cord-343791-0vykwml5	282	29	product	product	NN
cord-343791-0vykwml5	282	30	,	,	,
cord-343791-0vykwml5	282	31	and	and	CC
cord-343791-0vykwml5	283	1	its	-PRON-	PRP$
cord-343791-0vykwml5	283	2	safety	safety	NN
cord-343791-0vykwml5	283	3	and	and	CC
cord-343791-0vykwml5	283	4	efficacy	efficacy	NN
cord-343791-0vykwml5	283	5	were	be	VBD
cord-343791-0vykwml5	283	6	verified	verify	VBN
cord-343791-0vykwml5	283	7	in	in	IN
cord-343791-0vykwml5	283	8	a	a	DT
cord-343791-0vykwml5	283	9	clinical	clinical	JJ
cord-343791-0vykwml5	283	10	trial	trial	NN
cord-343791-0vykwml5	283	11	to	to	TO
cord-343791-0vykwml5	283	12	treat	treat	VB
cord-343791-0vykwml5	283	13	dental	dental	JJ
cord-343791-0vykwml5	283	14	caries	carie	NNS
cord-343791-0vykwml5	283	15	.	.	.
cord-343791-0vykwml5	284	1	[	[	-LRB-
cord-343791-0vykwml5	284	2	78	78	CD
cord-343791-0vykwml5	284	3	]	]	-RRB-
cord-343791-0vykwml5	285	1	In	in	IN
cord-343791-0vykwml5	285	2	2012	2012	CD
cord-343791-0vykwml5	285	3	it	-PRON-	PRP
cord-343791-0vykwml5	285	4	received	receive	VBD
cord-343791-0vykwml5	285	5	market	market	NN
cord-343791-0vykwml5	285	6	approval	approval	NN
cord-343791-0vykwml5	285	7	(	(	-LRB-
cord-343791-0vykwml5	285	8	CE	ce	NN
cord-343791-0vykwml5	285	9	-	-	HYPH
cord-343791-0vykwml5	285	10	label	label	NN
cord-343791-0vykwml5	285	11	)	)	-RRB-
cord-343791-0vykwml5	285	12	for	for	IN
cord-343791-0vykwml5	285	13	medical	medical	JJ
cord-343791-0vykwml5	285	14	devices	device	NNS
cord-343791-0vykwml5	285	15	in	in	IN
cord-343791-0vykwml5	285	16	the	the	DT
cord-343791-0vykwml5	285	17	EU	EU	NNP
cord-343791-0vykwml5	285	18	.	.	.
cord-343791-0vykwml5	286	1	In	in	IN
cord-343791-0vykwml5	286	2	keeping	keep	VBG
cord-343791-0vykwml5	286	3	with	with	IN
cord-343791-0vykwml5	286	4	the	the	DT
cord-343791-0vykwml5	286	5	original	original	JJ
cord-343791-0vykwml5	286	6	peptide	peptide	NN
cord-343791-0vykwml5	286	7	design	design	NN
cord-343791-0vykwml5	286	8	,	,	,
cord-343791-0vykwml5	286	9	the	the	DT
cord-343791-0vykwml5	286	10	final	final	JJ
cord-343791-0vykwml5	286	11	formulation	formulation	NN
cord-343791-0vykwml5	286	12	of	of	IN
cord-343791-0vykwml5	286	13	Curodont	Curodont	NNP
cord-343791-0vykwml5	286	14	is	be	VBZ
cord-343791-0vykwml5	286	15	composed	compose	VBN
cord-343791-0vykwml5	286	16	of	of	IN
cord-343791-0vykwml5	286	17	only	only	RB
cord-343791-0vykwml5	286	18	a	a	DT
cord-343791-0vykwml5	286	19	monomeric	monomeric	JJ
cord-343791-0vykwml5	286	20	11-amino	11-amino	CD
cord-343791-0vykwml5	286	21	acid	acid	NN
cord-343791-0vykwml5	286	22	peptide	peptide	NN
cord-343791-0vykwml5	286	23	(	(	-LRB-
cord-343791-0vykwml5	286	24	P	p	NN
cord-343791-0vykwml5	286	25	11	11	CD
cord-343791-0vykwml5	286	26	)	)	-RRB-
cord-343791-0vykwml5	286	27	dissolved	dissolve	VBD
cord-343791-0vykwml5	286	28	in	in	IN
cord-343791-0vykwml5	286	29	water	water	NN
cord-343791-0vykwml5	286	30	,	,	,
cord-343791-0vykwml5	286	31	with	with	IN
cord-343791-0vykwml5	286	32	no	no	DT
cord-343791-0vykwml5	286	33	additional	additional	JJ
cord-343791-0vykwml5	286	34	bioactive	bioactive	JJ
cord-343791-0vykwml5	286	35	agents	agent	NNS
cord-343791-0vykwml5	286	36	.	.	.
cord-343791-0vykwml5	287	1	[	[	-LRB-
cord-343791-0vykwml5	287	2	80	80	CD
cord-343791-0vykwml5	287	3	]	]	-RRB-
cord-343791-0vykwml5	288	1	Following	follow	VBG
cord-343791-0vykwml5	288	2	a	a	DT
cord-343791-0vykwml5	288	3	single	single	JJ
cord-343791-0vykwml5	288	4	application	application	NN
cord-343791-0vykwml5	288	5	,	,	,
cord-343791-0vykwml5	288	6	the	the	DT
cord-343791-0vykwml5	288	7	size	size	NN
cord-343791-0vykwml5	288	8	and	and	CC
cord-343791-0vykwml5	288	9	color	color	NN
cord-343791-0vykwml5	288	10	of	of	IN
cord-343791-0vykwml5	288	11	lesions	lesion	NNS
cord-343791-0vykwml5	288	12	are	be	VBP
cord-343791-0vykwml5	288	13	significantly	significantly	RB
cord-343791-0vykwml5	288	14	improved	improve	VBN
cord-343791-0vykwml5	288	15	,	,	,
cord-343791-0vykwml5	288	16	as	as	IN
cord-343791-0vykwml5	288	17	observed	observe	VBN
cord-343791-0vykwml5	288	18	one	one	CD
cord-343791-0vykwml5	288	19	month	month	NN
cord-343791-0vykwml5	288	20	after	after	IN
cord-343791-0vykwml5	288	21	treatment	treatment	NN
cord-343791-0vykwml5	288	22	.	.	.
cord-343791-0vykwml5	289	1	[	[	-LRB-
cord-343791-0vykwml5	289	2	80	80	CD
cord-343791-0vykwml5	289	3	,	,	,
cord-343791-0vykwml5	289	4	81	81	CD
cord-343791-0vykwml5	289	5	]	]	-RRB-
cord-343791-0vykwml5	289	6	Peptide	peptide	NN
cord-343791-0vykwml5	289	7	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	289	8	have	have	VBP
cord-343791-0vykwml5	289	9	also	also	RB
cord-343791-0vykwml5	289	10	increasingly	increasingly	RB
cord-343791-0vykwml5	289	11	received	receive	VBN
cord-343791-0vykwml5	289	12	attention	attention	NN
cord-343791-0vykwml5	289	13	in	in	IN
cord-343791-0vykwml5	289	14	immunological	immunological	JJ
cord-343791-0vykwml5	289	15	contexts	context	NNS
cord-343791-0vykwml5	289	16	,	,	,
cord-343791-0vykwml5	289	17	an	an	DT
cord-343791-0vykwml5	289	18	area	area	NN
cord-343791-0vykwml5	289	19	in	in	IN
cord-343791-0vykwml5	289	20	which	which	WDT
cord-343791-0vykwml5	289	21	our	-PRON-	PRP$
cord-343791-0vykwml5	289	22	group	group	NN
cord-343791-0vykwml5	289	23	is	be	VBZ
cord-343791-0vykwml5	289	24	active	active	JJ
cord-343791-0vykwml5	289	25	.	.	.
cord-343791-0vykwml5	290	1	However	however	RB
cord-343791-0vykwml5	290	2	,	,	,
cord-343791-0vykwml5	290	3	because	because	IN
cord-343791-0vykwml5	290	4	the	the	DT
cord-343791-0vykwml5	290	5	focus	focus	NN
cord-343791-0vykwml5	290	6	here	here	RB
cord-343791-0vykwml5	290	7	is	be	VBZ
cord-343791-0vykwml5	290	8	on	on	IN
cord-343791-0vykwml5	290	9	clinical	clinical	JJ
cord-343791-0vykwml5	290	10	development	development	NN
cord-343791-0vykwml5	290	11	and	and	CC
cord-343791-0vykwml5	290	12	these	these	DT
cord-343791-0vykwml5	290	13	materials	material	NNS
cord-343791-0vykwml5	290	14	have	have	VBP
cord-343791-0vykwml5	290	15	not	not	RB
cord-343791-0vykwml5	290	16	yet	yet	RB
cord-343791-0vykwml5	290	17	reached	reach	VBN
cord-343791-0vykwml5	290	18	clinical	clinical	JJ
cord-343791-0vykwml5	290	19	trials	trial	NNS
cord-343791-0vykwml5	290	20	,	,	,
cord-343791-0vykwml5	290	21	these	these	DT
cord-343791-0vykwml5	290	22	applications	application	NNS
cord-343791-0vykwml5	290	23	will	will	MD
cord-343791-0vykwml5	290	24	be	be	VB
cord-343791-0vykwml5	290	25	only	only	RB
cord-343791-0vykwml5	290	26	briefly	briefly	RB
cord-343791-0vykwml5	290	27	described	describe	VBN
cord-343791-0vykwml5	290	28	,	,	,
cord-343791-0vykwml5	290	29	and	and	CC
cord-343791-0vykwml5	290	30	the	the	DT
cord-343791-0vykwml5	290	31	reader	reader	NN
cord-343791-0vykwml5	290	32	is	be	VBZ
cord-343791-0vykwml5	290	33	referred	refer	VBN
cord-343791-0vykwml5	290	34	to	to	IN
cord-343791-0vykwml5	290	35	other	other	JJ
cord-343791-0vykwml5	290	36	recent	recent	JJ
cord-343791-0vykwml5	290	37	reviews	review	NNS
cord-343791-0vykwml5	290	38	for	for	IN
cord-343791-0vykwml5	290	39	more	more	RBR
cord-343791-0vykwml5	290	40	expansive	expansive	JJ
cord-343791-0vykwml5	290	41	descriptions	description	NNS
cord-343791-0vykwml5	290	42	of	of	IN
cord-343791-0vykwml5	290	43	this	this	DT
cord-343791-0vykwml5	290	44	burgeoning	burgeon	VBG
cord-343791-0vykwml5	290	45	field	field	NN
cord-343791-0vykwml5	290	46	.	.	.
cord-343791-0vykwml5	291	1	[	[	-LRB-
cord-343791-0vykwml5	291	2	1	1	CD
cord-343791-0vykwml5	291	3	,	,	,
cord-343791-0vykwml5	291	4	2	2	CD
cord-343791-0vykwml5	291	5	,	,	,
cord-343791-0vykwml5	291	6	82	82	CD
cord-343791-0vykwml5	291	7	,	,	,
cord-343791-0vykwml5	291	8	83	83	CD
cord-343791-0vykwml5	291	9	]	]	-RRB-
cord-343791-0vykwml5	292	1	After	after	IN
cord-343791-0vykwml5	292	2	the	the	DT
cord-343791-0vykwml5	292	3	discovery	discovery	NN
cord-343791-0vykwml5	292	4	that	that	IN
cord-343791-0vykwml5	292	5	β	β	NN
cord-343791-0vykwml5	292	6	-	-	HYPH
cord-343791-0vykwml5	292	7	sheet	sheet	NN
cord-343791-0vykwml5	292	8	fibrillized	fibrillize	VBN
cord-343791-0vykwml5	292	9	peptides	peptide	NNS
cord-343791-0vykwml5	292	10	can	can	MD
cord-343791-0vykwml5	292	11	raise	raise	VB
cord-343791-0vykwml5	292	12	strong	strong	JJ
cord-343791-0vykwml5	292	13	antibody	antibody	NN
cord-343791-0vykwml5	292	14	responses	response	NNS
cord-343791-0vykwml5	292	15	without	without	IN
cord-343791-0vykwml5	292	16	the	the	DT
cord-343791-0vykwml5	292	17	requirement	requirement	NN
cord-343791-0vykwml5	292	18	of	of	IN
cord-343791-0vykwml5	292	19	supplemental	supplemental	JJ
cord-343791-0vykwml5	292	20	adjuvant	adjuvant	NN
cord-343791-0vykwml5	292	21	,	,	,
cord-343791-0vykwml5	292	22	[	[	-LRB-
cord-343791-0vykwml5	292	23	84	84	CD
cord-343791-0vykwml5	292	24	]	]	-RRB-
cord-343791-0vykwml5	292	25	these	these	DT
cord-343791-0vykwml5	292	26	materials	material	NNS
cord-343791-0vykwml5	292	27	have	have	VBP
cord-343791-0vykwml5	292	28	been	be	VBN
cord-343791-0vykwml5	292	29	investigated	investigate	VBN
cord-343791-0vykwml5	292	30	preclinically	preclinically	RB
cord-343791-0vykwml5	292	31	toward	toward	IN
cord-343791-0vykwml5	292	32	a	a	DT
cord-343791-0vykwml5	292	33	range	range	NN
cord-343791-0vykwml5	292	34	of	of	IN
cord-343791-0vykwml5	292	35	diseases	disease	NNS
cord-343791-0vykwml5	292	36	and	and	CC
cord-343791-0vykwml5	292	37	conditions	condition	NNS
cord-343791-0vykwml5	292	38	including	include	VBG
cord-343791-0vykwml5	292	39	malaria	malaria	NN
cord-343791-0vykwml5	292	40	,	,	,
cord-343791-0vykwml5	292	41	[	[	-LRB-
cord-343791-0vykwml5	292	42	85	85	CD
cord-343791-0vykwml5	292	43	]	]	-RRB-
cord-343791-0vykwml5	292	44	Staphylococus	Staphylococus	NNP
cord-343791-0vykwml5	292	45	aureus	aureus	NN
cord-343791-0vykwml5	292	46	infections	infection	NNS
cord-343791-0vykwml5	292	47	,	,	,
cord-343791-0vykwml5	292	48	[	[	-LRB-
cord-343791-0vykwml5	292	49	86	86	CD
cord-343791-0vykwml5	292	50	]	]	-RRB-
cord-343791-0vykwml5	292	51	influenza	influenza	NN
cord-343791-0vykwml5	292	52	,	,	,
cord-343791-0vykwml5	292	53	[	[	-LRB-
cord-343791-0vykwml5	292	54	87	87	CD
cord-343791-0vykwml5	292	55	]	]	-RRB-
cord-343791-0vykwml5	292	56	West	West	NNP
cord-343791-0vykwml5	292	57	Nile	Nile	NNP
cord-343791-0vykwml5	292	58	virus	virus	NN
cord-343791-0vykwml5	292	59	,	,	,
cord-343791-0vykwml5	292	60	cancer	cancer	NN
cord-343791-0vykwml5	292	61	,	,	,
cord-343791-0vykwml5	292	62	[	[	-LRB-
cord-343791-0vykwml5	292	63	88	88	CD
cord-343791-0vykwml5	292	64	]	]	-RRB-
cord-343791-0vykwml5	292	65	and	and	CC
cord-343791-0vykwml5	292	66	cocaine	cocaine	NN
cord-343791-0vykwml5	292	67	abuse	abuse	NN
cord-343791-0vykwml5	292	68	.	.	.
cord-343791-0vykwml5	293	1	[	[	-LRB-
cord-343791-0vykwml5	293	2	89	89	CD
cord-343791-0vykwml5	293	3	]	]	-RRB-
cord-343791-0vykwml5	294	1	Immunogenic	immunogenic	JJ
cord-343791-0vykwml5	294	2	peptide	peptide	NN
cord-343791-0vykwml5	294	3	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	294	4	are	be	VBP
cord-343791-0vykwml5	294	5	produced	produce	VBN
cord-343791-0vykwml5	294	6	by	by	IN
cord-343791-0vykwml5	294	7	co	co	NN
cord-343791-0vykwml5	294	8	-	-	JJ
cord-343791-0vykwml5	294	9	assembling	assembling	JJ
cord-343791-0vykwml5	294	10	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	294	11	peptides	peptide	NNS
cord-343791-0vykwml5	294	12	extended	extend	VBN
cord-343791-0vykwml5	294	13	with	with	IN
cord-343791-0vykwml5	294	14	specific	specific	JJ
cord-343791-0vykwml5	294	15	epitopes	epitope	NNS
cord-343791-0vykwml5	294	16	or	or	CC
cord-343791-0vykwml5	294	17	haptens	hapten	NNS
cord-343791-0vykwml5	294	18	along	along	IN
cord-343791-0vykwml5	294	19	with	with	IN
cord-343791-0vykwml5	294	20	other	other	JJ
cord-343791-0vykwml5	294	21	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	294	22	peptides	peptide	NNS
cord-343791-0vykwml5	294	23	bearing	bear	VBG
cord-343791-0vykwml5	294	24	T	T	NNP
cord-343791-0vykwml5	294	25	-	-	HYPH
cord-343791-0vykwml5	294	26	cell	cell	NN
cord-343791-0vykwml5	294	27	epitopes	epitope	NNS
cord-343791-0vykwml5	294	28	.	.	.
cord-343791-0vykwml5	295	1	They	-PRON-	PRP
cord-343791-0vykwml5	295	2	stimulate	stimulate	VBP
cord-343791-0vykwml5	295	3	antibody	antibody	NN
cord-343791-0vykwml5	295	4	/	/	SYM
cord-343791-0vykwml5	295	5	B	b	NN
cord-343791-0vykwml5	295	6	-	-	HYPH
cord-343791-0vykwml5	295	7	cell	cell	NN
cord-343791-0vykwml5	295	8	responses	response	NNS
cord-343791-0vykwml5	295	9	,	,	,
cord-343791-0vykwml5	295	10	CD4	CD4	NNP
cord-343791-0vykwml5	295	11	T	T	NNP
cord-343791-0vykwml5	295	12	-	-	HYPH
cord-343791-0vykwml5	295	13	cell	cell	NN
cord-343791-0vykwml5	295	14	responses	response	NNS
cord-343791-0vykwml5	295	15	,	,	,
cord-343791-0vykwml5	295	16	and	and	CC
cord-343791-0vykwml5	295	17	CD8	CD8	NNP
cord-343791-0vykwml5	295	18	T	T	NNP
cord-343791-0vykwml5	295	19	-	-	HYPH
cord-343791-0vykwml5	295	20	cell	cell	NN
cord-343791-0vykwml5	295	21	responses	response	NNS
cord-343791-0vykwml5	295	22	[	[	-LRB-
cord-343791-0vykwml5	295	23	90	90	CD
cord-343791-0vykwml5	295	24	]	]	-RRB-
cord-343791-0vykwml5	295	25	which	which	WDT
cord-343791-0vykwml5	295	26	can	can	MD
cord-343791-0vykwml5	295	27	be	be	VB
cord-343791-0vykwml5	295	28	raised	raise	VBN
cord-343791-0vykwml5	295	29	in	in	IN
cord-343791-0vykwml5	295	30	tunable	tunable	JJ
cord-343791-0vykwml5	295	31	magnitudes	magnitude	NNS
cord-343791-0vykwml5	295	32	without	without	IN
cord-343791-0vykwml5	295	33	causing	cause	VBG
cord-343791-0vykwml5	295	34	inflammation	inflammation	NN
cord-343791-0vykwml5	295	35	.	.	.
cord-343791-0vykwml5	296	1	[	[	-LRB-
cord-343791-0vykwml5	296	2	85	85	CD
cord-343791-0vykwml5	296	3	,	,	,
cord-343791-0vykwml5	296	4	86	86	CD
cord-343791-0vykwml5	296	5	,	,	,
cord-343791-0vykwml5	296	6	89	89	CD
cord-343791-0vykwml5	296	7	]	]	-RRB-
cord-343791-0vykwml5	297	1	Other	other	JJ
cord-343791-0vykwml5	297	2	recent	recent	JJ
cord-343791-0vykwml5	297	3	extensions	extension	NNS
cord-343791-0vykwml5	297	4	of	of	IN
cord-343791-0vykwml5	297	5	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	297	6	peptide	peptide	NN
cord-343791-0vykwml5	297	7	technologies	technology	NNS
cord-343791-0vykwml5	297	8	have	have	VBP
cord-343791-0vykwml5	297	9	included	include	VBN
cord-343791-0vykwml5	297	10	assemblies	assembly	NNS
cord-343791-0vykwml5	297	11	containing	contain	VBG
cord-343791-0vykwml5	297	12	both	both	DT
cord-343791-0vykwml5	297	13	peptides	peptide	NNS
cord-343791-0vykwml5	297	14	and	and	CC
cord-343791-0vykwml5	297	15	other	other	JJ
cord-343791-0vykwml5	297	16	therapeutically	therapeutically	RB
cord-343791-0vykwml5	297	17	active	active	JJ
cord-343791-0vykwml5	297	18	compounds	compound	NNS
cord-343791-0vykwml5	297	19	.	.	.
cord-343791-0vykwml5	298	1	In	in	IN
cord-343791-0vykwml5	298	2	these	these	DT
cord-343791-0vykwml5	298	3	drug	drug	NN
cord-343791-0vykwml5	298	4	-	-	HYPH
cord-343791-0vykwml5	298	5	peptide	peptide	NN
cord-343791-0vykwml5	298	6	formulations	formulation	NNS
cord-343791-0vykwml5	298	7	,	,	,
cord-343791-0vykwml5	298	8	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	298	9	,	,	,
cord-343791-0vykwml5	298	10	π	π	NNP
cord-343791-0vykwml5	298	11	-	-	HYPH
cord-343791-0vykwml5	298	12	π	π	NNP
cord-343791-0vykwml5	298	13	,	,	,
cord-343791-0vykwml5	298	14	and	and	CC
cord-343791-0vykwml5	298	15	electrostatic	electrostatic	JJ
cord-343791-0vykwml5	298	16	interactions	interaction	NNS
cord-343791-0vykwml5	298	17	induce	induce	VBP
cord-343791-0vykwml5	298	18	the	the	DT
cord-343791-0vykwml5	298	19	assembly	assembly	NN
cord-343791-0vykwml5	298	20	of	of	IN
cord-343791-0vykwml5	298	21	the	the	DT
cord-343791-0vykwml5	298	22	molecules	molecule	NNS
cord-343791-0vykwml5	298	23	into	into	IN
cord-343791-0vykwml5	298	24	fibrillar	fibrillar	NNP
cord-343791-0vykwml5	298	25	networks	network	NNS
cord-343791-0vykwml5	298	26	much	much	RB
cord-343791-0vykwml5	298	27	in	in	IN
cord-343791-0vykwml5	298	28	the	the	DT
cord-343791-0vykwml5	298	29	same	same	JJ
cord-343791-0vykwml5	298	30	way	way	NN
cord-343791-0vykwml5	298	31	as	as	IN
cord-343791-0vykwml5	298	32	pure	pure	JJ
cord-343791-0vykwml5	298	33	peptide	peptide	NN
cord-343791-0vykwml5	298	34	systems	system	NNS
cord-343791-0vykwml5	298	35	.	.	.
cord-343791-0vykwml5	299	1	[	[	-LRB-
cord-343791-0vykwml5	299	2	91	91	CD
cord-343791-0vykwml5	299	3	,	,	,
cord-343791-0vykwml5	299	4	92	92	CD
cord-343791-0vykwml5	299	5	]	]	-RRB-
cord-343791-0vykwml5	300	1	A	a	DT
cord-343791-0vykwml5	300	2	recently	recently	RB
cord-343791-0vykwml5	300	3	described	describe	VBN
cord-343791-0vykwml5	300	4	example	example	NN
cord-343791-0vykwml5	300	5	is	be	VBZ
cord-343791-0vykwml5	300	6	a	a	DT
cord-343791-0vykwml5	300	7	strategy	strategy	NN
cord-343791-0vykwml5	300	8	in	in	IN
cord-343791-0vykwml5	300	9	which	which	WDT
cord-343791-0vykwml5	300	10	the	the	DT
cord-343791-0vykwml5	300	11	US	US	NNP
cord-343791-0vykwml5	300	12	food	food	NN
cord-343791-0vykwml5	300	13	and	and	CC
cord-343791-0vykwml5	300	14	drug	drug	NNP
cord-343791-0vykwml5	300	15	administration	administration	NN
cord-343791-0vykwml5	300	16	(	(	-LRB-
cord-343791-0vykwml5	300	17	FDA)-approved	fda)-approve	VBN
cord-343791-0vykwml5	300	18	anticancer	anticancer	JJ
cord-343791-0vykwml5	300	19	drug	drug	NN
cord-343791-0vykwml5	300	20	Pemetrexed	Pemetrexed	NNP
cord-343791-0vykwml5	300	21	was	be	VBD
cord-343791-0vykwml5	300	22	conjugated	conjugate	VBN
cord-343791-0vykwml5	300	23	to	to	IN
cord-343791-0vykwml5	300	24	a	a	DT
cord-343791-0vykwml5	300	25	four	four	CD
cord-343791-0vykwml5	300	26	-	-	HYPH
cord-343791-0vykwml5	300	27	amino	amino	NN
cord-343791-0vykwml5	300	28	acid	acid	NN
cord-343791-0vykwml5	300	29	peptide	peptide	NN
cord-343791-0vykwml5	300	30	and	and	CC
cord-343791-0vykwml5	300	31	used	use	VBD
cord-343791-0vykwml5	300	32	both	both	CC
cord-343791-0vykwml5	300	33	as	as	IN
cord-343791-0vykwml5	300	34	an	an	DT
cord-343791-0vykwml5	300	35	MRI	MRI	NNP
cord-343791-0vykwml5	300	36	contrast	contrast	NN
cord-343791-0vykwml5	300	37	agent	agent	NN
cord-343791-0vykwml5	300	38	and	and	CC
cord-343791-0vykwml5	300	39	to	to	TO
cord-343791-0vykwml5	300	40	form	form	VB
cord-343791-0vykwml5	300	41	drug	drug	NN
cord-343791-0vykwml5	300	42	depots	depot	NNS
cord-343791-0vykwml5	300	43	near	near	IN
cord-343791-0vykwml5	300	44	tumor	tumor	NN
cord-343791-0vykwml5	300	45	sites	site	NNS
cord-343791-0vykwml5	300	46	.	.	.
cord-343791-0vykwml5	301	1	[	[	-LRB-
cord-343791-0vykwml5	301	2	93	93	CD
cord-343791-0vykwml5	301	3	]	]	-RRB-
cord-343791-0vykwml5	302	1	The	the	DT
cord-343791-0vykwml5	302	2	dual	dual	JJ
cord-343791-0vykwml5	302	3	function	function	NN
cord-343791-0vykwml5	302	4	of	of	IN
cord-343791-0vykwml5	302	5	the	the	DT
cord-343791-0vykwml5	302	6	material	material	NN
cord-343791-0vykwml5	302	7	(	(	-LRB-
cord-343791-0vykwml5	302	8	contrast	contrast	NN
cord-343791-0vykwml5	302	9	and	and	CC
cord-343791-0vykwml5	302	10	depot	depot	NN
cord-343791-0vykwml5	302	11	formation	formation	NN
cord-343791-0vykwml5	302	12	)	)	-RRB-
cord-343791-0vykwml5	302	13	was	be	VBD
cord-343791-0vykwml5	302	14	possible	possible	JJ
cord-343791-0vykwml5	302	15	because	because	IN
cord-343791-0vykwml5	302	16	the	the	DT
cord-343791-0vykwml5	302	17	peptide	peptide	NN
cord-343791-0vykwml5	302	18	-	-	HYPH
cord-343791-0vykwml5	302	19	drug	drug	NN
cord-343791-0vykwml5	302	20	conjugate	conjugate	NN
cord-343791-0vykwml5	302	21	formed	form	VBN
cord-343791-0vykwml5	302	22	fibrillar	fibrillar	NNP
cord-343791-0vykwml5	302	23	hydrogels	hydrogel	NNS
cord-343791-0vykwml5	302	24	at	at	IN
cord-343791-0vykwml5	302	25	high	high	JJ
cord-343791-0vykwml5	302	26	concentrations	concentration	NNS
cord-343791-0vykwml5	302	27	to	to	TO
cord-343791-0vykwml5	302	28	form	form	VB
cord-343791-0vykwml5	302	29	the	the	DT
cord-343791-0vykwml5	302	30	drug	drug	NN
cord-343791-0vykwml5	302	31	depot	depot	NN
cord-343791-0vykwml5	302	32	,	,	,
cord-343791-0vykwml5	302	33	while	while	IN
cord-343791-0vykwml5	302	34	lower	low	JJR
cord-343791-0vykwml5	302	35	concentrations	concentration	NNS
cord-343791-0vykwml5	302	36	in	in	IN
cord-343791-0vykwml5	302	37	the	the	DT
cord-343791-0vykwml5	302	38	circulation	circulation	NN
cord-343791-0vykwml5	302	39	acted	act	VBD
cord-343791-0vykwml5	302	40	as	as	IN
cord-343791-0vykwml5	302	41	the	the	DT
cord-343791-0vykwml5	302	42	MRI	MRI	NNP
cord-343791-0vykwml5	302	43	contrast	contrast	NN
cord-343791-0vykwml5	302	44	agent	agent	NN
cord-343791-0vykwml5	302	45	.	.	.
cord-343791-0vykwml5	303	1	A	a	DT
cord-343791-0vykwml5	303	2	range	range	NN
cord-343791-0vykwml5	303	3	of	of	IN
cord-343791-0vykwml5	303	4	other	other	JJ
cord-343791-0vykwml5	303	5	strategies	strategy	NNS
cord-343791-0vykwml5	303	6	have	have	VBP
cord-343791-0vykwml5	303	7	likewise	likewise	RB
cord-343791-0vykwml5	303	8	employed	employ	VBN
cord-343791-0vykwml5	303	9	fibrillizing	fibrillize	VBG
cord-343791-0vykwml5	303	10	peptides	peptide	NNS
cord-343791-0vykwml5	303	11	to	to	TO
cord-343791-0vykwml5	303	12	alter	alter	VB
cord-343791-0vykwml5	303	13	the	the	DT
cord-343791-0vykwml5	303	14	delivery	delivery	NN
cord-343791-0vykwml5	303	15	or	or	CC
cord-343791-0vykwml5	303	16	pharmacokinetics	pharmacokinetic	NNS
cord-343791-0vykwml5	303	17	of	of	IN
cord-343791-0vykwml5	303	18	various	various	JJ
cord-343791-0vykwml5	303	19	drugs	drug	NNS
cord-343791-0vykwml5	303	20	.	.	.
cord-343791-0vykwml5	304	1	For	for	IN
cord-343791-0vykwml5	304	2	example	example	NN
cord-343791-0vykwml5	304	3	,	,	,
cord-343791-0vykwml5	304	4	Hartgerink	Hartgerink	NNP
cord-343791-0vykwml5	304	5	and	and	CC
cord-343791-0vykwml5	304	6	co	co	NNS
cord-343791-0vykwml5	304	7	-	-	NNS
cord-343791-0vykwml5	304	8	workers	worker	NNS
cord-343791-0vykwml5	304	9	showed	show	VBD
cord-343791-0vykwml5	304	10	that	that	IN
cord-343791-0vykwml5	304	11	several	several	JJ
cord-343791-0vykwml5	304	12	different	different	JJ
cord-343791-0vykwml5	304	13	multivalent	multivalent	JJ
cord-343791-0vykwml5	304	14	drug	drug	NN
cord-343791-0vykwml5	304	15	molecules	molecule	NNS
cord-343791-0vykwml5	304	16	such	such	JJ
cord-343791-0vykwml5	304	17	as	as	IN
cord-343791-0vykwml5	304	18	clodronate	clodronate	NN
cord-343791-0vykwml5	304	19	,	,	,
cord-343791-0vykwml5	304	20	heparin	heparin	NN
cord-343791-0vykwml5	304	21	,	,	,
cord-343791-0vykwml5	304	22	and	and	CC
cord-343791-0vykwml5	304	23	suramin	suramin	NN
cord-343791-0vykwml5	304	24	could	could	MD
cord-343791-0vykwml5	304	25	be	be	VB
cord-343791-0vykwml5	304	26	used	use	VBN
cord-343791-0vykwml5	304	27	to	to	TO
cord-343791-0vykwml5	304	28	stabilize	stabilize	VB
cord-343791-0vykwml5	304	29	β	β	NN
cord-343791-0vykwml5	304	30	-	-	HYPH
cord-343791-0vykwml5	304	31	sheet	sheet	NN
cord-343791-0vykwml5	304	32	fibrillar	fibrillar	NNP
cord-343791-0vykwml5	304	33	hydrogels	hydrogel	NNS
cord-343791-0vykwml5	304	34	by	by	IN
cord-343791-0vykwml5	304	35	shielding	shield	VBG
cord-343791-0vykwml5	304	36	the	the	DT
cord-343791-0vykwml5	304	37	surface	surface	NN
cord-343791-0vykwml5	304	38	charges	charge	NNS
cord-343791-0vykwml5	304	39	on	on	IN
cord-343791-0vykwml5	304	40	the	the	DT
cord-343791-0vykwml5	304	41	peptides	peptide	NNS
cord-343791-0vykwml5	304	42	that	that	WDT
cord-343791-0vykwml5	304	43	would	would	MD
cord-343791-0vykwml5	304	44	otherwise	otherwise	RB
cord-343791-0vykwml5	304	45	inhibit	inhibit	VB
cord-343791-0vykwml5	304	46	gelation	gelation	NN
cord-343791-0vykwml5	304	47	,	,	,
cord-343791-0vykwml5	304	48	thus	thus	RB
cord-343791-0vykwml5	304	49	forming	form	VBG
cord-343791-0vykwml5	304	50	drug	drug	NN
cord-343791-0vykwml5	304	51	depots	depot	NNS
cord-343791-0vykwml5	304	52	.	.	.
cord-343791-0vykwml5	305	1	[	[	-LRB-
cord-343791-0vykwml5	305	2	94	94	CD
cord-343791-0vykwml5	305	3	]	]	-RRB-
cord-343791-0vykwml5	305	4	Naphthalene	naphthalene	NN
cord-343791-0vykwml5	305	5	-	-	HYPH
cord-343791-0vykwml5	305	6	modified	modify	VBN
cord-343791-0vykwml5	305	7	peptides	peptide	NNS
cord-343791-0vykwml5	305	8	have	have	VBP
cord-343791-0vykwml5	305	9	been	be	VBN
cord-343791-0vykwml5	305	10	explored	explore	VBN
cord-343791-0vykwml5	305	11	to	to	TO
cord-343791-0vykwml5	305	12	carry	carry	VB
cord-343791-0vykwml5	305	13	hydrophobic	hydrophobic	JJ
cord-343791-0vykwml5	305	14	drugs	drug	NNS
cord-343791-0vykwml5	305	15	such	such	JJ
cord-343791-0vykwml5	305	16	as	as	IN
cord-343791-0vykwml5	305	17	Curcumin	Curcumin	NNP
cord-343791-0vykwml5	305	18	,	,	,
cord-343791-0vykwml5	305	19	which	which	WDT
cord-343791-0vykwml5	305	20	require	require	VBP
cord-343791-0vykwml5	305	21	carrier	carrier	NN
cord-343791-0vykwml5	305	22	transport	transport	NN
cord-343791-0vykwml5	305	23	due	due	IN
cord-343791-0vykwml5	305	24	to	to	IN
cord-343791-0vykwml5	305	25	their	-PRON-	PRP$
cord-343791-0vykwml5	305	26	low	low	JJ
cord-343791-0vykwml5	305	27	solubility	solubility	NN
cord-343791-0vykwml5	305	28	.	.	.
cord-343791-0vykwml5	306	1	[	[	-LRB-
cord-343791-0vykwml5	306	2	95	95	CD
cord-343791-0vykwml5	306	3	]	]	-RRB-
cord-343791-0vykwml5	307	1	These	these	DT
cord-343791-0vykwml5	307	2	examples	example	NNS
cord-343791-0vykwml5	307	3	highlight	highlight	VBP
cord-343791-0vykwml5	307	4	considerable	considerable	JJ
cord-343791-0vykwml5	307	5	future	future	JJ
cord-343791-0vykwml5	307	6	potential	potential	NN
cord-343791-0vykwml5	307	7	for	for	IN
cord-343791-0vykwml5	307	8	peptide	peptide	NN
cord-343791-0vykwml5	307	9	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	307	10	toward	toward	IN
cord-343791-0vykwml5	307	11	clinical	clinical	JJ
cord-343791-0vykwml5	307	12	applications	application	NNS
cord-343791-0vykwml5	307	13	.	.	.
cord-343791-0vykwml5	308	1	Alongside	alongside	IN
cord-343791-0vykwml5	308	2	the	the	DT
cord-343791-0vykwml5	308	3	use	use	NN
cord-343791-0vykwml5	308	4	of	of	IN
cord-343791-0vykwml5	308	5	β	β	NN
cord-343791-0vykwml5	308	6	-	-	HYPH
cord-343791-0vykwml5	308	7	sheet	sheet	NN
cord-343791-0vykwml5	308	8	peptides	peptide	NNS
cord-343791-0vykwml5	308	9	,	,	,
cord-343791-0vykwml5	308	10	peptide	peptide	NN
cord-343791-0vykwml5	308	11	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	308	12	composed	compose	VBN
cord-343791-0vykwml5	308	13	of	of	IN
cord-343791-0vykwml5	308	14	a	a	DT
cord-343791-0vykwml5	308	15	peptide	peptide	JJ
cord-343791-0vykwml5	308	16	head	head	NN
cord-343791-0vykwml5	308	17	group	group	NN
cord-343791-0vykwml5	308	18	and	and	CC
cord-343791-0vykwml5	308	19	an	an	DT
cord-343791-0vykwml5	308	20	alkyl	alkyl	JJ
cord-343791-0vykwml5	308	21	tail	tail	NN
cord-343791-0vykwml5	308	22	are	be	VBP
cord-343791-0vykwml5	308	23	a	a	DT
cord-343791-0vykwml5	308	24	related	related	JJ
cord-343791-0vykwml5	308	25	class	class	NN
cord-343791-0vykwml5	308	26	of	of	IN
cord-343791-0vykwml5	308	27	materials	material	NNS
cord-343791-0vykwml5	308	28	that	that	WDT
cord-343791-0vykwml5	308	29	have	have	VBP
cord-343791-0vykwml5	308	30	seen	see	VBN
cord-343791-0vykwml5	308	31	considerable	considerable	JJ
cord-343791-0vykwml5	308	32	interest	interest	NN
cord-343791-0vykwml5	308	33	for	for	IN
cord-343791-0vykwml5	308	34	creating	create	VBG
cord-343791-0vykwml5	308	35	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	308	36	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	308	37	(	(	-LRB-
cord-343791-0vykwml5	308	38	see	see	VB
cord-343791-0vykwml5	308	39	Figure	figure	NN
cord-343791-0vykwml5	308	40	2A	2a	CD
cord-343791-0vykwml5	308	41	)	)	-RRB-
cord-343791-0vykwml5	308	42	.	.	.
cord-343791-0vykwml5	309	1	Although	although	IN
cord-343791-0vykwml5	309	2	the	the	DT
cord-343791-0vykwml5	309	3	self	self	NN
cord-343791-0vykwml5	309	4	-	-	HYPH
cord-343791-0vykwml5	309	5	assembly	assembly	NN
cord-343791-0vykwml5	309	6	of	of	IN
cord-343791-0vykwml5	309	7	peptide	peptide	JJ
cord-343791-0vykwml5	309	8	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	309	9	into	into	IN
cord-343791-0vykwml5	309	10	spherical	spherical	JJ
cord-343791-0vykwml5	309	11	structures	structure	NNS
cord-343791-0vykwml5	309	12	had	have	VBD
cord-343791-0vykwml5	309	13	been	be	VBN
cord-343791-0vykwml5	309	14	known	know	VBN
cord-343791-0vykwml5	309	15	for	for	IN
cord-343791-0vykwml5	309	16	some	some	DT
cord-343791-0vykwml5	309	17	time	time	NN
cord-343791-0vykwml5	309	18	,	,	,
cord-343791-0vykwml5	309	19	[	[	-LRB-
cord-343791-0vykwml5	309	20	96	96	CD
cord-343791-0vykwml5	309	21	]	]	-RRB-
cord-343791-0vykwml5	309	22	the	the	DT
cord-343791-0vykwml5	309	23	landmark	landmark	JJ
cord-343791-0vykwml5	309	24	2001	2001	CD
cord-343791-0vykwml5	309	25	paper	paper	NN
cord-343791-0vykwml5	309	26	by	by	IN
cord-343791-0vykwml5	309	27	Hartgerink	Hartgerink	NNP
cord-343791-0vykwml5	309	28	,	,	,
cord-343791-0vykwml5	309	29	Stupp	Stupp	NNP
cord-343791-0vykwml5	309	30	,	,	,
cord-343791-0vykwml5	309	31	and	and	CC
cord-343791-0vykwml5	309	32	colleagues	colleague	NNS
cord-343791-0vykwml5	309	33	catalyzed	catalyze	VBD
cord-343791-0vykwml5	309	34	much	much	JJ
cord-343791-0vykwml5	309	35	interest	interest	NN
cord-343791-0vykwml5	309	36	in	in	IN
cord-343791-0vykwml5	309	37	the	the	DT
cord-343791-0vykwml5	309	38	ability	ability	NN
cord-343791-0vykwml5	309	39	of	of	IN
cord-343791-0vykwml5	309	40	this	this	DT
cord-343791-0vykwml5	309	41	class	class	NN
cord-343791-0vykwml5	309	42	of	of	IN
cord-343791-0vykwml5	309	43	molecule	molecule	NN
cord-343791-0vykwml5	309	44	to	to	TO
cord-343791-0vykwml5	309	45	form	form	VB
cord-343791-0vykwml5	309	46	nanofibrous	nanofibrous	JJ
cord-343791-0vykwml5	309	47	materials	material	NNS
cord-343791-0vykwml5	309	48	for	for	IN
cord-343791-0vykwml5	309	49	specific	specific	JJ
cord-343791-0vykwml5	309	50	biomedical	biomedical	JJ
cord-343791-0vykwml5	309	51	applications	application	NNS
cord-343791-0vykwml5	309	52	.	.	.
cord-343791-0vykwml5	310	1	[	[	-LRB-
cord-343791-0vykwml5	310	2	11	11	CD
cord-343791-0vykwml5	310	3	]	]	-RRB-
cord-343791-0vykwml5	311	1	In	in	IN
cord-343791-0vykwml5	311	2	this	this	DT
cord-343791-0vykwml5	311	3	report	report	NN
cord-343791-0vykwml5	311	4	,	,	,
cord-343791-0vykwml5	311	5	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	311	6	spontaneously	spontaneously	RB
cord-343791-0vykwml5	311	7	assembled	assemble	VBD
cord-343791-0vykwml5	311	8	from	from	IN
cord-343791-0vykwml5	311	9	peptide	peptide	JJ
cord-343791-0vykwml5	311	10	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	311	11	into	into	IN
cord-343791-0vykwml5	311	12	parallel	parallel	JJ
cord-343791-0vykwml5	311	13	bundles	bundle	NNS
cord-343791-0vykwml5	311	14	and	and	CC
cord-343791-0vykwml5	311	15	promoted	promote	VBN
cord-343791-0vykwml5	311	16	mineralization	mineralization	NN
cord-343791-0vykwml5	311	17	of	of	IN
cord-343791-0vykwml5	311	18	hydroxyapatite	hydroxyapatite	NN
cord-343791-0vykwml5	311	19	.	.	.
cord-343791-0vykwml5	312	1	[	[	-LRB-
cord-343791-0vykwml5	312	2	11	11	CD
cord-343791-0vykwml5	312	3	]	]	-RRB-
cord-343791-0vykwml5	313	1	Since	since	IN
cord-343791-0vykwml5	313	2	then	then	RB
cord-343791-0vykwml5	313	3	,	,	,
cord-343791-0vykwml5	313	4	fibrillar	fibrillar	NNP
cord-343791-0vykwml5	313	5	peptide	peptide	NN
cord-343791-0vykwml5	313	6	amphiphile	amphiphile	NN
cord-343791-0vykwml5	313	7	materials	material	NNS
cord-343791-0vykwml5	313	8	have	have	VBP
cord-343791-0vykwml5	313	9	been	be	VBN
cord-343791-0vykwml5	313	10	explored	explore	VBN
cord-343791-0vykwml5	313	11	in	in	IN
cord-343791-0vykwml5	313	12	a	a	DT
cord-343791-0vykwml5	313	13	broad	broad	JJ
cord-343791-0vykwml5	313	14	range	range	NN
cord-343791-0vykwml5	313	15	of	of	IN
cord-343791-0vykwml5	313	16	medical	medical	JJ
cord-343791-0vykwml5	313	17	applications	application	NNS
cord-343791-0vykwml5	313	18	ranging	range	VBG
cord-343791-0vykwml5	313	19	between	between	IN
cord-343791-0vykwml5	313	20	wound	wound	NN
cord-343791-0vykwml5	313	21	healing	healing	NN
cord-343791-0vykwml5	313	22	,	,	,
cord-343791-0vykwml5	313	23	[	[	-LRB-
cord-343791-0vykwml5	313	24	97	97	CD
cord-343791-0vykwml5	313	25	]	]	-RRB-
cord-343791-0vykwml5	313	26	bone	bone	NN
cord-343791-0vykwml5	313	27	healing	healing	NN
cord-343791-0vykwml5	313	28	,	,	,
cord-343791-0vykwml5	313	29	[	[	-LRB-
cord-343791-0vykwml5	313	30	98	98	CD
cord-343791-0vykwml5	313	31	]	]	-RRB-
cord-343791-0vykwml5	313	32	the	the	DT
cord-343791-0vykwml5	313	33	delivery	delivery	NN
cord-343791-0vykwml5	313	34	of	of	IN
cord-343791-0vykwml5	313	35	proteins	protein	NNS
cord-343791-0vykwml5	313	36	,	,	,
cord-343791-0vykwml5	313	37	[	[	-LRB-
cord-343791-0vykwml5	313	38	99	99	CD
cord-343791-0vykwml5	313	39	]	]	-RRB-
cord-343791-0vykwml5	313	40	nervous	nervous	JJ
cord-343791-0vykwml5	313	41	tissue	tissue	NN
cord-343791-0vykwml5	313	42	repair	repair	NN
cord-343791-0vykwml5	313	43	,	,	,
cord-343791-0vykwml5	313	44	[	[	-LRB-
cord-343791-0vykwml5	313	45	100	100	CD
cord-343791-0vykwml5	313	46	]	]	-RRB-
cord-343791-0vykwml5	313	47	and	and	CC
cord-343791-0vykwml5	313	48	others	other	NNS
cord-343791-0vykwml5	313	49	.	.	.
cord-343791-0vykwml5	314	1	Additional	additional	JJ
cord-343791-0vykwml5	314	2	chemistries	chemistry	NNS
cord-343791-0vykwml5	314	3	have	have	VBP
cord-343791-0vykwml5	314	4	been	be	VBN
cord-343791-0vykwml5	314	5	developed	develop	VBN
cord-343791-0vykwml5	314	6	to	to	TO
cord-343791-0vykwml5	314	7	stabilize	stabilize	VB
cord-343791-0vykwml5	314	8	the	the	DT
cord-343791-0vykwml5	314	9	materials	material	NNS
cord-343791-0vykwml5	314	10	.	.	.
cord-343791-0vykwml5	315	1	For	for	IN
cord-343791-0vykwml5	315	2	example	example	NN
cord-343791-0vykwml5	315	3	,	,	,
cord-343791-0vykwml5	315	4	toward	toward	IN
cord-343791-0vykwml5	315	5	applications	application	NNS
cord-343791-0vykwml5	315	6	where	where	WRB
cord-343791-0vykwml5	315	7	mechanical	mechanical	JJ
cord-343791-0vykwml5	315	8	integrity	integrity	NN
cord-343791-0vykwml5	315	9	is	be	VBZ
cord-343791-0vykwml5	315	10	necessary	necessary	JJ
cord-343791-0vykwml5	315	11	,	,	,
cord-343791-0vykwml5	315	12	adhesive	adhesive	JJ
cord-343791-0vykwml5	315	13	groups	group	NNS
cord-343791-0vykwml5	315	14	have	have	VBP
cord-343791-0vykwml5	315	15	been	be	VBN
cord-343791-0vykwml5	315	16	incorporated	incorporate	VBN
cord-343791-0vykwml5	315	17	into	into	IN
cord-343791-0vykwml5	315	18	the	the	DT
cord-343791-0vykwml5	315	19	hydrophilic	hydrophilic	JJ
cord-343791-0vykwml5	315	20	heads	head	NNS
cord-343791-0vykwml5	315	21	to	to	TO
cord-343791-0vykwml5	315	22	render	render	VB
cord-343791-0vykwml5	315	23	the	the	DT
cord-343791-0vykwml5	315	24	fibrous	fibrous	JJ
cord-343791-0vykwml5	315	25	gels	gel	NNS
cord-343791-0vykwml5	315	26	self	self	NN
cord-343791-0vykwml5	315	27	-	-	HYPH
cord-343791-0vykwml5	315	28	healing	healing	NN
cord-343791-0vykwml5	315	29	after	after	IN
cord-343791-0vykwml5	315	30	they	-PRON-	PRP
cord-343791-0vykwml5	315	31	are	be	VBP
cord-343791-0vykwml5	315	32	strained	strain	VBN
cord-343791-0vykwml5	315	33	mechanically	mechanically	RB
cord-343791-0vykwml5	315	34	.	.	.
cord-343791-0vykwml5	316	1	[	[	-LRB-
cord-343791-0vykwml5	316	2	101	101	CD
cord-343791-0vykwml5	316	3	]	]	-RRB-
cord-343791-0vykwml5	317	1	A	a	DT
cord-343791-0vykwml5	317	2	recent	recent	JJ
cord-343791-0vykwml5	317	3	example	example	NN
cord-343791-0vykwml5	317	4	of	of	IN
cord-343791-0vykwml5	317	5	clinically	clinically	RB
cord-343791-0vykwml5	317	6	directed	direct	VBN
cord-343791-0vykwml5	317	7	peptide	peptide	NN
cord-343791-0vykwml5	317	8	amphiphile	amphiphile	NNP
cord-343791-0vykwml5	317	9	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	317	10	used	use	VBD
cord-343791-0vykwml5	317	11	them	-PRON-	PRP
cord-343791-0vykwml5	317	12	to	to	TO
cord-343791-0vykwml5	317	13	deliver	deliver	VB
cord-343791-0vykwml5	317	14	bioactive	bioactive	JJ
cord-343791-0vykwml5	317	15	proteins	protein	NNS
cord-343791-0vykwml5	317	16	such	such	JJ
cord-343791-0vykwml5	317	17	as	as	IN
cord-343791-0vykwml5	317	18	bone	bone	NN
cord-343791-0vykwml5	317	19	morphogenic	morphogenic	JJ
cord-343791-0vykwml5	317	20	protein	protein	NN
cord-343791-0vykwml5	317	21	(	(	-LRB-
cord-343791-0vykwml5	317	22	BMP	BMP	NNP
cord-343791-0vykwml5	317	23	)	)	-RRB-
cord-343791-0vykwml5	317	24	to	to	TO
cord-343791-0vykwml5	317	25	induce	induce	VB
cord-343791-0vykwml5	317	26	osteogenesis	osteogenesis	NN
cord-343791-0vykwml5	317	27	in	in	IN
cord-343791-0vykwml5	317	28	an	an	DT
cord-343791-0vykwml5	317	29	environment	environment	NN
cord-343791-0vykwml5	317	30	mimicking	mimic	VBG
cord-343791-0vykwml5	317	31	native	native	JJ
cord-343791-0vykwml5	317	32	bone	bone	NN
cord-343791-0vykwml5	317	33	growth	growth	NN
cord-343791-0vykwml5	317	34	.	.	.
cord-343791-0vykwml5	318	1	[	[	-LRB-
cord-343791-0vykwml5	318	2	98	98	CD
cord-343791-0vykwml5	318	3	]	]	-RRB-
cord-343791-0vykwml5	319	1	Other	other	JJ
cord-343791-0vykwml5	319	2	examples	example	NNS
cord-343791-0vykwml5	319	3	have	have	VBP
cord-343791-0vykwml5	319	4	included	include	VBN
cord-343791-0vykwml5	319	5	nerve	nerve	NN
cord-343791-0vykwml5	319	6	repair	repair	NN
cord-343791-0vykwml5	319	7	,	,	,
cord-343791-0vykwml5	319	8	which	which	WDT
cord-343791-0vykwml5	319	9	benefitted	benefit	VBD
cord-343791-0vykwml5	319	10	from	from	IN
cord-343791-0vykwml5	319	11	the	the	DT
cord-343791-0vykwml5	319	12	bioactivity	bioactivity	NN
cord-343791-0vykwml5	319	13	and	and	CC
cord-343791-0vykwml5	319	14	parallel	parallel	JJ
cord-343791-0vykwml5	319	15	alignment	alignment	NN
cord-343791-0vykwml5	319	16	of	of	IN
cord-343791-0vykwml5	319	17	fibrous	fibrous	JJ
cord-343791-0vykwml5	319	18	scaffolds	scaffold	NNS
cord-343791-0vykwml5	319	19	,	,	,
cord-343791-0vykwml5	319	20	[	[	-LRB-
cord-343791-0vykwml5	319	21	102	102	CD
cord-343791-0vykwml5	319	22	]	]	-RRB-
cord-343791-0vykwml5	319	23	and	and	CC
cord-343791-0vykwml5	319	24	burn	burn	VB
cord-343791-0vykwml5	319	25	injuries	injury	NNS
cord-343791-0vykwml5	319	26	,	,	,
cord-343791-0vykwml5	319	27	where	where	WRB
cord-343791-0vykwml5	319	28	heparin	heparin	NN
cord-343791-0vykwml5	319	29	-	-	HYPH
cord-343791-0vykwml5	319	30	mimetic	mimetic	NN
cord-343791-0vykwml5	319	31	gels	gel	NNS
cord-343791-0vykwml5	319	32	induced	induce	VBD
cord-343791-0vykwml5	319	33	the	the	DT
cord-343791-0vykwml5	319	34	formation	formation	NN
cord-343791-0vykwml5	319	35	of	of	IN
cord-343791-0vykwml5	319	36	vascularized	vascularized	JJ
cord-343791-0vykwml5	319	37	,	,	,
cord-343791-0vykwml5	319	38	collagen	collagen	NN
cord-343791-0vykwml5	319	39	-	-	HYPH
cord-343791-0vykwml5	319	40	rich	rich	JJ
cord-343791-0vykwml5	319	41	tissues	tissue	NNS
cord-343791-0vykwml5	319	42	.	.	.
cord-343791-0vykwml5	320	1	[	[	-LRB-
cord-343791-0vykwml5	320	2	97	97	CD
cord-343791-0vykwml5	320	3	]	]	-RRB-
cord-343791-0vykwml5	320	4	Peptide	peptide	NN
cord-343791-0vykwml5	320	5	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	320	6	have	have	VBP
cord-343791-0vykwml5	320	7	also	also	RB
cord-343791-0vykwml5	320	8	been	be	VBN
cord-343791-0vykwml5	320	9	used	use	VBN
cord-343791-0vykwml5	320	10	to	to	TO
cord-343791-0vykwml5	320	11	deliver	deliver	VB
cord-343791-0vykwml5	320	12	bioactive	bioactive	JJ
cord-343791-0vykwml5	320	13	cargo	cargo	NN
cord-343791-0vykwml5	320	14	outside	outside	IN
cord-343791-0vykwml5	320	15	of	of	IN
cord-343791-0vykwml5	320	16	the	the	DT
cord-343791-0vykwml5	320	17	regenerative	regenerative	JJ
cord-343791-0vykwml5	320	18	context	context	NN
cord-343791-0vykwml5	320	19	,	,	,
cord-343791-0vykwml5	320	20	including	include	VBG
cord-343791-0vykwml5	320	21	the	the	DT
cord-343791-0vykwml5	320	22	electrostatic	electrostatic	JJ
cord-343791-0vykwml5	320	23	complexation	complexation	NN
cord-343791-0vykwml5	320	24	of	of	IN
cord-343791-0vykwml5	320	25	antisense	antisense	NNP
cord-343791-0vykwml5	320	26	oligonucleotides	oligonucleotide	NNS
cord-343791-0vykwml5	320	27	to	to	IN
cord-343791-0vykwml5	320	28	a	a	DT
cord-343791-0vykwml5	320	29	cationic	cationic	JJ
cord-343791-0vykwml5	320	30	peptide	peptide	NN
cord-343791-0vykwml5	320	31	head	head	NN
cord-343791-0vykwml5	320	32	to	to	TO
cord-343791-0vykwml5	320	33	form	form	VB
cord-343791-0vykwml5	320	34	a	a	DT
cord-343791-0vykwml5	320	35	depot	depot	NN
cord-343791-0vykwml5	320	36	for	for	IN
cord-343791-0vykwml5	320	37	sustained	sustained	JJ
cord-343791-0vykwml5	320	38	release	release	NN
cord-343791-0vykwml5	320	39	of	of	IN
cord-343791-0vykwml5	320	40	oligonucleotide	oligonucleotide	NN
cord-343791-0vykwml5	320	41	.	.	.
cord-343791-0vykwml5	321	1	[	[	-LRB-
cord-343791-0vykwml5	321	2	103	103	CD
cord-343791-0vykwml5	321	3	]	]	-RRB-
cord-343791-0vykwml5	322	1	Because	because	IN
cord-343791-0vykwml5	322	2	networks	network	NNS
cord-343791-0vykwml5	322	3	of	of	IN
cord-343791-0vykwml5	322	4	peptide	peptide	NN
cord-343791-0vykwml5	322	5	-	-	HYPH
cord-343791-0vykwml5	322	6	based	base	VBN
cord-343791-0vykwml5	322	7	fibers	fiber	NNS
cord-343791-0vykwml5	322	8	are	be	VBP
cord-343791-0vykwml5	322	9	morphologically	morphologically	RB
cord-343791-0vykwml5	322	10	similar	similar	JJ
cord-343791-0vykwml5	322	11	to	to	IN
cord-343791-0vykwml5	322	12	the	the	DT
cord-343791-0vykwml5	322	13	extracellular	extracellular	JJ
cord-343791-0vykwml5	322	14	matrix	matrix	NN
cord-343791-0vykwml5	322	15	,	,	,
cord-343791-0vykwml5	322	16	they	-PRON-	PRP
cord-343791-0vykwml5	322	17	have	have	VBP
cord-343791-0vykwml5	322	18	also	also	RB
cord-343791-0vykwml5	322	19	been	be	VBN
cord-343791-0vykwml5	322	20	highly	highly	RB
cord-343791-0vykwml5	322	21	useful	useful	JJ
cord-343791-0vykwml5	322	22	as	as	IN
cord-343791-0vykwml5	322	23	in	in	IN
cord-343791-0vykwml5	322	24	vitro	vitro	FW
cord-343791-0vykwml5	322	25	culture	culture	NN
cord-343791-0vykwml5	322	26	materials	material	NNS
cord-343791-0vykwml5	322	27	[	[	-LRB-
cord-343791-0vykwml5	322	28	104	104	CD
cord-343791-0vykwml5	322	29	]	]	-RRB-
cord-343791-0vykwml5	322	30	and	and	CC
cord-343791-0vykwml5	322	31	can	can	MD
cord-343791-0vykwml5	322	32	be	be	VB
cord-343791-0vykwml5	322	33	utilized	utilize	VBN
cord-343791-0vykwml5	322	34	as	as	IN
cord-343791-0vykwml5	322	35	cell	cell	NN
cord-343791-0vykwml5	322	36	delivery	delivery	NN
cord-343791-0vykwml5	322	37	vehicles	vehicle	NNS
cord-343791-0vykwml5	322	38	,	,	,
cord-343791-0vykwml5	322	39	as	as	IN
cord-343791-0vykwml5	322	40	demonstrated	demonstrate	VBN
cord-343791-0vykwml5	322	41	in	in	IN
cord-343791-0vykwml5	322	42	the	the	DT
cord-343791-0vykwml5	322	43	transplantation	transplantation	NN
cord-343791-0vykwml5	322	44	of	of	IN
cord-343791-0vykwml5	322	45	islet	islet	NN
cord-343791-0vykwml5	322	46	cells	cell	NNS
cord-343791-0vykwml5	322	47	[	[	-LRB-
cord-343791-0vykwml5	322	48	105	105	CD
cord-343791-0vykwml5	322	49	]	]	-RRB-
cord-343791-0vykwml5	322	50	and	and	CC
cord-343791-0vykwml5	322	51	bone	bone	NN
cord-343791-0vykwml5	322	52	marrow	marrow	NN
cord-343791-0vykwml5	322	53	-	-	HYPH
cord-343791-0vykwml5	322	54	derived	derive	VBN
cord-343791-0vykwml5	322	55	pro	pro	JJ
cord-343791-0vykwml5	322	56	-	-	JJ
cord-343791-0vykwml5	322	57	angiogenic	angiogenic	JJ
cord-343791-0vykwml5	322	58	cells	cell	NNS
cord-343791-0vykwml5	322	59	cultured	culture	VBN
cord-343791-0vykwml5	322	60	prior	prior	RB
cord-343791-0vykwml5	322	61	to	to	IN
cord-343791-0vykwml5	322	62	transplantation	transplantation	NN
cord-343791-0vykwml5	322	63	.	.	.
cord-343791-0vykwml5	323	1	[	[	-LRB-
cord-343791-0vykwml5	323	2	106	106	CD
cord-343791-0vykwml5	323	3	]	]	-RRB-
cord-343791-0vykwml5	324	1	Although	although	IN
cord-343791-0vykwml5	324	2	work	work	NN
cord-343791-0vykwml5	324	3	with	with	IN
cord-343791-0vykwml5	324	4	fibrous	fibrous	JJ
cord-343791-0vykwml5	324	5	peptide	peptide	NN
cord-343791-0vykwml5	324	6	amphiphiles	amphiphile	NNS
cord-343791-0vykwml5	324	7	has	have	VBZ
cord-343791-0vykwml5	324	8	remained	remain	VBN
cord-343791-0vykwml5	324	9	largely	largely	RB
cord-343791-0vykwml5	324	10	preclinical	preclinical	JJ
cord-343791-0vykwml5	324	11	to	to	IN
cord-343791-0vykwml5	324	12	date	date	NN
cord-343791-0vykwml5	324	13	,	,	,
cord-343791-0vykwml5	324	14	is	be	VBZ
cord-343791-0vykwml5	324	15	anticipated	anticipate	VBN
cord-343791-0vykwml5	324	16	that	that	IN
cord-343791-0vykwml5	324	17	the	the	DT
cord-343791-0vykwml5	324	18	coming	come	VBG
cord-343791-0vykwml5	324	19	years	year	NNS
cord-343791-0vykwml5	324	20	will	will	MD
cord-343791-0vykwml5	324	21	see	see	VB
cord-343791-0vykwml5	324	22	many	many	JJ
cord-343791-0vykwml5	324	23	of	of	IN
cord-343791-0vykwml5	324	24	these	these	DT
cord-343791-0vykwml5	324	25	applications	application	NNS
cord-343791-0vykwml5	324	26	brought	bring	VBN
cord-343791-0vykwml5	324	27	forward	forward	RB
cord-343791-0vykwml5	324	28	into	into	IN
cord-343791-0vykwml5	324	29	approved	approve	VBN
cord-343791-0vykwml5	324	30	therapeutics	therapeutic	NNS
cord-343791-0vykwml5	324	31	.	.	.
cord-343791-0vykwml5	325	1	Filamentous	filamentous	JJ
cord-343791-0vykwml5	325	2	bacteriophages	bacteriophage	NNS
cord-343791-0vykwml5	325	3	(	(	-LRB-
cord-343791-0vykwml5	325	4	see	see	VB
cord-343791-0vykwml5	325	5	Figure	Figure	NNP
cord-343791-0vykwml5	325	6	2C	2c	CD
cord-343791-0vykwml5	325	7	)	)	-RRB-
cord-343791-0vykwml5	325	8	represent	represent	VBP
cord-343791-0vykwml5	325	9	an	an	DT
cord-343791-0vykwml5	325	10	additional	additional	JJ
cord-343791-0vykwml5	325	11	step	step	NN
cord-343791-0vykwml5	325	12	in	in	IN
cord-343791-0vykwml5	325	13	the	the	DT
cord-343791-0vykwml5	325	14	progression	progression	NN
cord-343791-0vykwml5	325	15	of	of	IN
cord-343791-0vykwml5	325	16	nanofiber	nanofiber	NN
cord-343791-0vykwml5	325	17	-	-	HYPH
cord-343791-0vykwml5	325	18	forming	form	VBG
cord-343791-0vykwml5	325	19	biomaterials	biomaterial	NNS
cord-343791-0vykwml5	325	20	.	.	.
cord-343791-0vykwml5	326	1	Although	although	IN
cord-343791-0vykwml5	326	2	their	-PRON-	PRP$
cord-343791-0vykwml5	326	3	production	production	NN
cord-343791-0vykwml5	326	4	is	be	VBZ
cord-343791-0vykwml5	326	5	considerably	considerably	RB
cord-343791-0vykwml5	326	6	different	different	JJ
cord-343791-0vykwml5	326	7	than	than	IN
cord-343791-0vykwml5	326	8	the	the	DT
cord-343791-0vykwml5	326	9	chemical	chemical	JJ
cord-343791-0vykwml5	326	10	synthesis	synthesis	NN
cord-343791-0vykwml5	326	11	of	of	IN
cord-343791-0vykwml5	326	12	PAs	pas	NN
cord-343791-0vykwml5	326	13	and	and	CC
cord-343791-0vykwml5	326	14	short	short	JJ
cord-343791-0vykwml5	326	15	peptides	peptide	NNS
cord-343791-0vykwml5	326	16	,	,	,
cord-343791-0vykwml5	326	17	their	-PRON-	PRP$
cord-343791-0vykwml5	326	18	elongated	elongated	JJ
cord-343791-0vykwml5	326	19	morphology	morphology	NN
cord-343791-0vykwml5	326	20	and	and	CC
cord-343791-0vykwml5	326	21	polyamino	polyamino	NN
cord-343791-0vykwml5	326	22	acid	acid	JJ
cord-343791-0vykwml5	326	23	composition	composition	NN
cord-343791-0vykwml5	326	24	are	be	VBP
cord-343791-0vykwml5	326	25	similar	similar	JJ
cord-343791-0vykwml5	326	26	in	in	IN
cord-343791-0vykwml5	326	27	some	some	DT
cord-343791-0vykwml5	326	28	respects	respect	NNS
cord-343791-0vykwml5	326	29	,	,	,
cord-343791-0vykwml5	326	30	and	and	CC
cord-343791-0vykwml5	326	31	can	can	MD
cord-343791-0vykwml5	326	32	be	be	VB
cord-343791-0vykwml5	326	33	used	use	VBN
cord-343791-0vykwml5	326	34	to	to	TO
cord-343791-0vykwml5	326	35	endow	endow	VB
cord-343791-0vykwml5	326	36	phage	phage	NN
cord-343791-0vykwml5	326	37	-	-	HYPH
cord-343791-0vykwml5	326	38	based	base	VBN
cord-343791-0vykwml5	326	39	materials	material	NNS
cord-343791-0vykwml5	326	40	with	with	IN
cord-343791-0vykwml5	326	41	similar	similar	JJ
cord-343791-0vykwml5	326	42	properties	property	NNS
cord-343791-0vykwml5	326	43	to	to	IN
cord-343791-0vykwml5	326	44	the	the	DT
cord-343791-0vykwml5	326	45	other	other	JJ
cord-343791-0vykwml5	326	46	fiber	fiber	NN
cord-343791-0vykwml5	326	47	-	-	HYPH
cord-343791-0vykwml5	326	48	forming	form	VBG
cord-343791-0vykwml5	326	49	platforms	platform	NNS
cord-343791-0vykwml5	326	50	discussed	discuss	VBN
cord-343791-0vykwml5	326	51	above	above	RB
cord-343791-0vykwml5	326	52	.	.	.
cord-343791-0vykwml5	327	1	Filamentous	Filamentous	NNP
cord-343791-0vykwml5	327	2	phages	phage	NNS
cord-343791-0vykwml5	327	3	have	have	VBP
cord-343791-0vykwml5	327	4	highly	highly	RB
cord-343791-0vykwml5	327	5	engineerable	engineerable	JJ
cord-343791-0vykwml5	327	6	coat	coat	NN
cord-343791-0vykwml5	327	7	proteins	protein	NNS
cord-343791-0vykwml5	327	8	which	which	WDT
cord-343791-0vykwml5	327	9	allow	allow	VBP
cord-343791-0vykwml5	327	10	the	the	DT
cord-343791-0vykwml5	327	11	high	high	JJ
cord-343791-0vykwml5	327	12	density	density	NN
cord-343791-0vykwml5	327	13	surface	surface	NN
cord-343791-0vykwml5	327	14	display	display	NN
cord-343791-0vykwml5	327	15	of	of	IN
cord-343791-0vykwml5	327	16	selected	select	VBN
cord-343791-0vykwml5	327	17	proteins	protein	NNS
cord-343791-0vykwml5	327	18	.	.	.
cord-343791-0vykwml5	328	1	M13	M13	NNP
cord-343791-0vykwml5	328	2	phage	phage	NN
cord-343791-0vykwml5	328	3	are	be	VBP
cord-343791-0vykwml5	328	4	naturally	naturally	RB
cord-343791-0vykwml5	328	5	filamentous	filamentous	JJ
cord-343791-0vykwml5	328	6	,	,	,
cord-343791-0vykwml5	328	7	and	and	CC
cord-343791-0vykwml5	328	8	they	-PRON-	PRP
cord-343791-0vykwml5	328	9	resemble	resemble	VBP
cord-343791-0vykwml5	328	10	peptide	peptide	JJ
cord-343791-0vykwml5	328	11	and	and	CC
cord-343791-0vykwml5	328	12	peptide	peptide	NN
cord-343791-0vykwml5	328	13	-	-	HYPH
cord-343791-0vykwml5	328	14	amphiphile	amphiphile	JJ
cord-343791-0vykwml5	328	15	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	328	16	in	in	IN
cord-343791-0vykwml5	328	17	morphology	morphology	NN
cord-343791-0vykwml5	328	18	as	as	IN
cord-343791-0vykwml5	328	19	they	-PRON-	PRP
cord-343791-0vykwml5	328	20	are	be	VBP
cord-343791-0vykwml5	329	1	less	less	JJR
cord-343791-0vykwml5	329	2	than	than	IN
cord-343791-0vykwml5	329	3	10	10	CD
cord-343791-0vykwml5	329	4	nm	nm	NN
cord-343791-0vykwml5	329	5	in	in	IN
cord-343791-0vykwml5	329	6	diameter	diameter	NN
cord-343791-0vykwml5	329	7	yet	yet	CC
cord-343791-0vykwml5	329	8	almost	almost	RB
cord-343791-0vykwml5	329	9	1	1	CD
cord-343791-0vykwml5	329	10	µm	µm	NN
cord-343791-0vykwml5	329	11	in	in	IN
cord-343791-0vykwml5	329	12	length	length	NN
cord-343791-0vykwml5	329	13	.	.	.
cord-343791-0vykwml5	330	1	Because	because	IN
cord-343791-0vykwml5	330	2	M13	M13	NNP
cord-343791-0vykwml5	330	3	bacteriophages	bacteriophage	NNS
cord-343791-0vykwml5	330	4	are	be	VBP
cord-343791-0vykwml5	330	5	unable	unable	JJ
cord-343791-0vykwml5	330	6	to	to	TO
cord-343791-0vykwml5	330	7	infect	infect	VB
cord-343791-0vykwml5	330	8	mammalian	mammalian	JJ
cord-343791-0vykwml5	330	9	cells	cell	NNS
cord-343791-0vykwml5	330	10	,	,	,
cord-343791-0vykwml5	330	11	there	there	EX
cord-343791-0vykwml5	330	12	is	be	VBZ
cord-343791-0vykwml5	330	13	negligible	negligible	JJ
cord-343791-0vykwml5	330	14	risk	risk	NN
cord-343791-0vykwml5	330	15	of	of	IN
cord-343791-0vykwml5	330	16	virulent	virulent	JJ
cord-343791-0vykwml5	330	17	infection	infection	NN
cord-343791-0vykwml5	330	18	when	when	WRB
cord-343791-0vykwml5	330	19	using	use	VBG
cord-343791-0vykwml5	330	20	these	these	DT
cord-343791-0vykwml5	330	21	viruses	virus	NNS
cord-343791-0vykwml5	330	22	in	in	IN
cord-343791-0vykwml5	330	23	medical	medical	JJ
cord-343791-0vykwml5	330	24	applications	application	NNS
cord-343791-0vykwml5	330	25	.	.	.
cord-343791-0vykwml5	331	1	For	for	IN
cord-343791-0vykwml5	331	2	these	these	DT
cord-343791-0vykwml5	331	3	reasons	reason	NNS
cord-343791-0vykwml5	331	4	,	,	,
cord-343791-0vykwml5	331	5	they	-PRON-	PRP
cord-343791-0vykwml5	331	6	have	have	VBP
cord-343791-0vykwml5	331	7	been	be	VBN
cord-343791-0vykwml5	331	8	historically	historically	RB
cord-343791-0vykwml5	331	9	used	use	VBN
cord-343791-0vykwml5	331	10	as	as	IN
cord-343791-0vykwml5	331	11	antimicrobial	antimicrobial	JJ
cord-343791-0vykwml5	331	12	agents	agent	NNS
cord-343791-0vykwml5	331	13	and	and	CC
cord-343791-0vykwml5	331	14	are	be	VBP
cord-343791-0vykwml5	331	15	currently	currently	RB
cord-343791-0vykwml5	331	16	approved	approve	VBN
cord-343791-0vykwml5	331	17	for	for	IN
cord-343791-0vykwml5	331	18	use	use	NN
cord-343791-0vykwml5	331	19	in	in	IN
cord-343791-0vykwml5	331	20	food	food	NN
cord-343791-0vykwml5	331	21	products	product	NNS
cord-343791-0vykwml5	331	22	,	,	,
cord-343791-0vykwml5	331	23	but	but	CC
cord-343791-0vykwml5	331	24	have	have	VBP
cord-343791-0vykwml5	331	25	had	have	VBN
cord-343791-0vykwml5	331	26	seen	see	VBN
cord-343791-0vykwml5	331	27	limited	limit	VBN
cord-343791-0vykwml5	331	28	use	use	NN
cord-343791-0vykwml5	331	29	in	in	IN
cord-343791-0vykwml5	331	30	clinical	clinical	JJ
cord-343791-0vykwml5	331	31	trials	trial	NNS
cord-343791-0vykwml5	331	32	as	as	IN
cord-343791-0vykwml5	331	33	therapeutics	therapeutic	NNS
cord-343791-0vykwml5	331	34	.	.	.
cord-343791-0vykwml5	332	1	A	a	DT
cord-343791-0vykwml5	332	2	few	few	JJ
cord-343791-0vykwml5	332	3	examples	example	NNS
cord-343791-0vykwml5	332	4	exist	exist	VBP
cord-343791-0vykwml5	332	5	where	where	WRB
cord-343791-0vykwml5	332	6	the	the	DT
cord-343791-0vykwml5	332	7	tissue	tissue	NN
cord-343791-0vykwml5	332	8	-	-	HYPH
cord-343791-0vykwml5	332	9	targeting	targeting	NN
cord-343791-0vykwml5	332	10	and	and	CC
cord-343791-0vykwml5	332	11	tumor	tumor	NN
cord-343791-0vykwml5	332	12	-	-	HYPH
cord-343791-0vykwml5	332	13	homing	home	VBG
cord-343791-0vykwml5	332	14	abilities	ability	NNS
cord-343791-0vykwml5	332	15	of	of	IN
cord-343791-0vykwml5	332	16	full	full	JJ
cord-343791-0vykwml5	332	17	phage	phage	NN
cord-343791-0vykwml5	332	18	libraries	library	NNS
cord-343791-0vykwml5	332	19	were	be	VBD
cord-343791-0vykwml5	332	20	tested	test	VBN
cord-343791-0vykwml5	332	21	in	in	IN
cord-343791-0vykwml5	332	22	humans	human	NNS
cord-343791-0vykwml5	332	23	.	.	.
cord-343791-0vykwml5	333	1	[	[	-LRB-
cord-343791-0vykwml5	333	2	107	107	CD
cord-343791-0vykwml5	333	3	,	,	,
cord-343791-0vykwml5	333	4	108	108	CD
cord-343791-0vykwml5	333	5	]	]	-RRB-
cord-343791-0vykwml5	333	6	Bacteriophages	bacteriophage	NNS
cord-343791-0vykwml5	333	7	were	be	VBD
cord-343791-0vykwml5	333	8	initially	initially	RB
cord-343791-0vykwml5	333	9	investigated	investigate	VBN
cord-343791-0vykwml5	333	10	as	as	IN
cord-343791-0vykwml5	333	11	nanomaterials	nanomaterial	NNS
cord-343791-0vykwml5	333	12	when	when	WRB
cord-343791-0vykwml5	333	13	they	-PRON-	PRP
cord-343791-0vykwml5	333	14	were	be	VBD
cord-343791-0vykwml5	333	15	observed	observe	VBN
cord-343791-0vykwml5	333	16	to	to	TO
cord-343791-0vykwml5	333	17	form	form	VB
cord-343791-0vykwml5	333	18	liquid	liquid	JJ
cord-343791-0vykwml5	333	19	crystals	crystal	NNS
cord-343791-0vykwml5	333	20	,	,	,
cord-343791-0vykwml5	333	21	and	and	CC
cord-343791-0vykwml5	333	22	they	-PRON-	PRP
cord-343791-0vykwml5	333	23	proved	prove	VBD
cord-343791-0vykwml5	333	24	useful	useful	JJ
cord-343791-0vykwml5	333	25	for	for	IN
cord-343791-0vykwml5	333	26	the	the	DT
cord-343791-0vykwml5	333	27	templating	templating	NN
cord-343791-0vykwml5	333	28	of	of	IN
cord-343791-0vykwml5	333	29	inorganic	inorganic	JJ
cord-343791-0vykwml5	333	30	structures	structure	NNS
cord-343791-0vykwml5	333	31	by	by	IN
cord-343791-0vykwml5	333	32	incorporating	incorporate	VBG
cord-343791-0vykwml5	333	33	metal	metal	NN
cord-343791-0vykwml5	333	34	binding	bind	VBG
cord-343791-0vykwml5	333	35	peptides	peptide	NNS
cord-343791-0vykwml5	333	36	on	on	IN
cord-343791-0vykwml5	333	37	the	the	DT
cord-343791-0vykwml5	333	38	viral	viral	JJ
cord-343791-0vykwml5	333	39	coat	coat	NN
cord-343791-0vykwml5	333	40	proteins	protein	NNS
cord-343791-0vykwml5	333	41	.	.	.
cord-343791-0vykwml5	334	1	[	[	-LRB-
cord-343791-0vykwml5	334	2	109	109	CD
cord-343791-0vykwml5	334	3	,	,	,
cord-343791-0vykwml5	334	4	110	110	CD
cord-343791-0vykwml5	334	5	]	]	-RRB-
cord-343791-0vykwml5	335	1	Following	follow	VBG
cord-343791-0vykwml5	335	2	the	the	DT
cord-343791-0vykwml5	335	3	discovery	discovery	NN
cord-343791-0vykwml5	335	4	of	of	IN
cord-343791-0vykwml5	335	5	this	this	DT
cord-343791-0vykwml5	335	6	functionality	functionality	NN
cord-343791-0vykwml5	335	7	,	,	,
cord-343791-0vykwml5	335	8	their	-PRON-	PRP$
cord-343791-0vykwml5	335	9	liquid	liquid	JJ
cord-343791-0vykwml5	335	10	crystalline	crystalline	JJ
cord-343791-0vykwml5	335	11	behavior	behavior	NN
cord-343791-0vykwml5	335	12	was	be	VBD
cord-343791-0vykwml5	335	13	utilized	utilize	VBN
cord-343791-0vykwml5	335	14	to	to	TO
cord-343791-0vykwml5	335	15	form	form	VB
cord-343791-0vykwml5	335	16	aligned	align	VBN
cord-343791-0vykwml5	335	17	matrices	matrix	NNS
cord-343791-0vykwml5	335	18	for	for	IN
cord-343791-0vykwml5	335	19	neural	neural	JJ
cord-343791-0vykwml5	335	20	cell	cell	NN
cord-343791-0vykwml5	335	21	culture	culture	NN
cord-343791-0vykwml5	335	22	by	by	IN
cord-343791-0vykwml5	335	23	displaying	display	VBG
cord-343791-0vykwml5	335	24	Arg	Arg	NNP
cord-343791-0vykwml5	335	25	-	-	HYPH
cord-343791-0vykwml5	335	26	Gly	Gly	NNP
cord-343791-0vykwml5	335	27	-	-	HYPH
cord-343791-0vykwml5	335	28	Asp	Asp	NNP
cord-343791-0vykwml5	335	29	(	(	-LRB-
cord-343791-0vykwml5	335	30	RGD	RGD	NNP
cord-343791-0vykwml5	335	31	)	)	-RRB-
cord-343791-0vykwml5	335	32	and	and	CC
cord-343791-0vykwml5	335	33	Ile	Ile	NNP
cord-343791-0vykwml5	335	34	-	-	HYPH
cord-343791-0vykwml5	335	35	Lys	Lys	NNP
cord-343791-0vykwml5	335	36	-	-	HYPH
cord-343791-0vykwml5	335	37	Val	Val	NNP
cord-343791-0vykwml5	335	38	-	-	HYPH
cord-343791-0vykwml5	335	39	Ala	Ala	NNP
cord-343791-0vykwml5	335	40	-	-	HYPH
cord-343791-0vykwml5	335	41	Val	Val	NNP
cord-343791-0vykwml5	335	42	(	(	-LRB-
cord-343791-0vykwml5	335	43	IKVAV	IKVAV	NNP
cord-343791-0vykwml5	335	44	)	)	-RRB-
cord-343791-0vykwml5	335	45	peptides	peptide	NNS
cord-343791-0vykwml5	335	46	on	on	IN
cord-343791-0vykwml5	335	47	the	the	DT
cord-343791-0vykwml5	335	48	phage	phage	NN
cord-343791-0vykwml5	335	49	surface	surface	NN
cord-343791-0vykwml5	335	50	.	.	.
cord-343791-0vykwml5	336	1	[	[	-LRB-
cord-343791-0vykwml5	336	2	111	111	CD
cord-343791-0vykwml5	336	3	]	]	-RRB-
cord-343791-0vykwml5	337	1	This	this	DT
cord-343791-0vykwml5	337	2	work	work	NN
cord-343791-0vykwml5	337	3	included	include	VBD
cord-343791-0vykwml5	337	4	the	the	DT
cord-343791-0vykwml5	337	5	use	use	NN
cord-343791-0vykwml5	337	6	of	of	IN
cord-343791-0vykwml5	337	7	standard	standard	JJ
cord-343791-0vykwml5	337	8	phage	phage	NN
cord-343791-0vykwml5	337	9	display	display	NN
cord-343791-0vykwml5	337	10	to	to	TO
cord-343791-0vykwml5	337	11	select	select	VB
cord-343791-0vykwml5	337	12	optimal	optimal	JJ
cord-343791-0vykwml5	337	13	8-amino	8-amino	CD
cord-343791-0vykwml5	337	14	acid	acid	JJ
cord-343791-0vykwml5	337	15	sequences	sequence	NNS
cord-343791-0vykwml5	337	16	for	for	IN
cord-343791-0vykwml5	337	17	receptor	receptor	NN
cord-343791-0vykwml5	337	18	binding	binding	NN
cord-343791-0vykwml5	337	19	,	,	,
cord-343791-0vykwml5	337	20	and	and	CC
cord-343791-0vykwml5	337	21	the	the	DT
cord-343791-0vykwml5	337	22	resultant	resultant	JJ
cord-343791-0vykwml5	337	23	filamentous	filamentous	JJ
cord-343791-0vykwml5	337	24	phages	phage	NNS
cord-343791-0vykwml5	337	25	were	be	VBD
cord-343791-0vykwml5	337	26	produced	produce	VBN
cord-343791-0vykwml5	337	27	in	in	IN
cord-343791-0vykwml5	337	28	E.	E.	NNP
cord-343791-0vykwml5	337	29	coli	coli	NNS
cord-343791-0vykwml5	337	30	,	,	,
cord-343791-0vykwml5	337	31	a	a	DT
cord-343791-0vykwml5	337	32	relatively	relatively	RB
cord-343791-0vykwml5	337	33	simple	simple	JJ
cord-343791-0vykwml5	337	34	manufacturing	manufacturing	NN
cord-343791-0vykwml5	337	35	process	process	NN
cord-343791-0vykwml5	337	36	that	that	WDT
cord-343791-0vykwml5	337	37	is	be	VBZ
cord-343791-0vykwml5	337	38	likely	likely	JJ
cord-343791-0vykwml5	337	39	to	to	TO
cord-343791-0vykwml5	337	40	be	be	VB
cord-343791-0vykwml5	337	41	scalable	scalable	JJ
cord-343791-0vykwml5	337	42	.	.	.
cord-343791-0vykwml5	338	1	In	in	IN
cord-343791-0vykwml5	338	2	another	another	DT
cord-343791-0vykwml5	338	3	recent	recent	JJ
cord-343791-0vykwml5	338	4	example	example	NN
cord-343791-0vykwml5	338	5	of	of	IN
cord-343791-0vykwml5	338	6	preclinical	preclinical	JJ
cord-343791-0vykwml5	338	7	materials	material	NNS
cord-343791-0vykwml5	338	8	development	development	NN
cord-343791-0vykwml5	338	9	using	use	VBG
cord-343791-0vykwml5	338	10	filamentous	filamentous	JJ
cord-343791-0vykwml5	338	11	phages	phage	NNS
cord-343791-0vykwml5	338	12	,	,	,
cord-343791-0vykwml5	338	13	their	-PRON-	PRP$
cord-343791-0vykwml5	338	14	self	self	NN
cord-343791-0vykwml5	338	15	-	-	HYPH
cord-343791-0vykwml5	338	16	templating	templating	NN
cord-343791-0vykwml5	338	17	properties	property	NNS
cord-343791-0vykwml5	338	18	proved	prove	VBD
cord-343791-0vykwml5	338	19	useful	useful	JJ
cord-343791-0vykwml5	338	20	for	for	IN
cord-343791-0vykwml5	338	21	controlling	control	VBG
cord-343791-0vykwml5	338	22	the	the	DT
cord-343791-0vykwml5	338	23	direction	direction	NN
cord-343791-0vykwml5	338	24	of	of	IN
cord-343791-0vykwml5	338	25	osteoblast	osteoblast	JJ
cord-343791-0vykwml5	338	26	growth	growth	NN
cord-343791-0vykwml5	338	27	using	use	VBG
cord-343791-0vykwml5	338	28	the	the	DT
cord-343791-0vykwml5	338	29	orientation	orientation	NN
cord-343791-0vykwml5	338	30	of	of	IN
cord-343791-0vykwml5	338	31	the	the	DT
cord-343791-0vykwml5	338	32	phage	phage	NN
cord-343791-0vykwml5	338	33	-	-	HYPH
cord-343791-0vykwml5	338	34	based	base	VBN
cord-343791-0vykwml5	338	35	substrate	substrate	NN
cord-343791-0vykwml5	338	36	.	.	.
cord-343791-0vykwml5	339	1	[	[	-LRB-
cord-343791-0vykwml5	339	2	112	112	CD
cord-343791-0vykwml5	339	3	]	]	-RRB-
cord-343791-0vykwml5	340	1	The	the	DT
cord-343791-0vykwml5	340	2	use	use	NN
cord-343791-0vykwml5	340	3	of	of	IN
cord-343791-0vykwml5	340	4	both	both	CC
cord-343791-0vykwml5	340	5	self	self	NN
cord-343791-0vykwml5	340	6	-	-	HYPH
cord-343791-0vykwml5	340	7	templated	template	VBN
cord-343791-0vykwml5	340	8	and	and	CC
cord-343791-0vykwml5	340	9	fabricated	fabricated	JJ
cord-343791-0vykwml5	340	10	directionality	directionality	NN
cord-343791-0vykwml5	340	11	in	in	IN
cord-343791-0vykwml5	340	12	phage	phage	NN
cord-343791-0vykwml5	340	13	substrates	substrate	NNS
cord-343791-0vykwml5	340	14	has	have	VBZ
cord-343791-0vykwml5	340	15	allowed	allow	VBN
cord-343791-0vykwml5	340	16	for	for	IN
cord-343791-0vykwml5	340	17	the	the	DT
cord-343791-0vykwml5	340	18	directional	directional	JJ
cord-343791-0vykwml5	340	19	growth	growth	NN
cord-343791-0vykwml5	340	20	of	of	IN
cord-343791-0vykwml5	340	21	human	human	JJ
cord-343791-0vykwml5	340	22	fibroblasts	fibroblast	NNS
cord-343791-0vykwml5	340	23	,	,	,
cord-343791-0vykwml5	340	24	[	[	-LRB-
cord-343791-0vykwml5	340	25	113	113	CD
cord-343791-0vykwml5	340	26	]	]	-RRB-
cord-343791-0vykwml5	340	27	proliferation	proliferation	NN
cord-343791-0vykwml5	340	28	and	and	CC
cord-343791-0vykwml5	340	29	elongation	elongation	NN
cord-343791-0vykwml5	340	30	of	of	IN
cord-343791-0vykwml5	340	31	neural	neural	JJ
cord-343791-0vykwml5	340	32	progenitor	progenitor	NN
cord-343791-0vykwml5	340	33	cells	cell	NNS
cord-343791-0vykwml5	340	34	,	,	,
cord-343791-0vykwml5	340	35	[	[	-LRB-
cord-343791-0vykwml5	340	36	114	114	CD
cord-343791-0vykwml5	340	37	]	]	-RRB-
cord-343791-0vykwml5	340	38	and	and	CC
cord-343791-0vykwml5	340	39	stimulated	stimulate	VBD
cord-343791-0vykwml5	340	40	the	the	DT
cord-343791-0vykwml5	340	41	differentiation	differentiation	NN
cord-343791-0vykwml5	340	42	of	of	IN
cord-343791-0vykwml5	340	43	mesenchymal	mesenchymal	JJ
cord-343791-0vykwml5	340	44	stem	stem	NN
cord-343791-0vykwml5	340	45	cells	cell	NNS
cord-343791-0vykwml5	340	46	into	into	IN
cord-343791-0vykwml5	340	47	osteoblasts	osteoblast	NNS
cord-343791-0vykwml5	340	48	when	when	WRB
cord-343791-0vykwml5	340	49	the	the	DT
cord-343791-0vykwml5	340	50	phages	phage	NNS
cord-343791-0vykwml5	340	51	displayed	display	VBD
cord-343791-0vykwml5	340	52	an	an	DT
cord-343791-0vykwml5	340	53	osteogenic	osteogenic	JJ
cord-343791-0vykwml5	340	54	peptide	peptide	NN
cord-343791-0vykwml5	340	55	on	on	IN
cord-343791-0vykwml5	340	56	their	-PRON-	PRP$
cord-343791-0vykwml5	340	57	surface	surface	NN
cord-343791-0vykwml5	340	58	.	.	.
cord-343791-0vykwml5	341	1	[	[	-LRB-
cord-343791-0vykwml5	341	2	115	115	CD
cord-343791-0vykwml5	341	3	]	]	-RRB-
cord-343791-0vykwml5	341	4	As	as	IN
cord-343791-0vykwml5	341	5	in	in	IN
cord-343791-0vykwml5	341	6	vivo	vivo	NN
cord-343791-0vykwml5	341	7	injectable	injectable	JJ
cord-343791-0vykwml5	341	8	materials	material	NNS
cord-343791-0vykwml5	341	9	,	,	,
cord-343791-0vykwml5	341	10	phages	phage	NNS
cord-343791-0vykwml5	341	11	have	have	VBP
cord-343791-0vykwml5	341	12	been	be	VBN
cord-343791-0vykwml5	341	13	used	use	VBN
cord-343791-0vykwml5	341	14	preclinically	preclinically	RB
cord-343791-0vykwml5	341	15	as	as	IN
cord-343791-0vykwml5	341	16	carriers	carrier	NNS
cord-343791-0vykwml5	341	17	for	for	IN
cord-343791-0vykwml5	341	18	magnetic	magnetic	JJ
cord-343791-0vykwml5	341	19	nanoparticles	nanoparticle	NNS
cord-343791-0vykwml5	341	20	for	for	IN
cord-343791-0vykwml5	341	21	targeted	target	VBN
cord-343791-0vykwml5	341	22	imaging	imaging	NN
cord-343791-0vykwml5	341	23	of	of	IN
cord-343791-0vykwml5	341	24	cancerous	cancerous	JJ
cord-343791-0vykwml5	341	25	tumors	tumor	NNS
cord-343791-0vykwml5	341	26	by	by	IN
cord-343791-0vykwml5	341	27	displaying	display	VBG
cord-343791-0vykwml5	341	28	a	a	DT
cord-343791-0vykwml5	341	29	high	high	JJ
cord-343791-0vykwml5	341	30	density	density	NN
cord-343791-0vykwml5	341	31	of	of	IN
cord-343791-0vykwml5	341	32	targeting	target	VBG
cord-343791-0vykwml5	341	33	ligands	ligand	NNS
cord-343791-0vykwml5	341	34	and	and	CC
cord-343791-0vykwml5	341	35	metal	metal	NN
cord-343791-0vykwml5	341	36	binding	bind	VBG
cord-343791-0vykwml5	341	37	peptides	peptide	NNS
cord-343791-0vykwml5	341	38	on	on	IN
cord-343791-0vykwml5	341	39	the	the	DT
cord-343791-0vykwml5	341	40	phage	phage	NN
cord-343791-0vykwml5	341	41	surface	surface	NN
cord-343791-0vykwml5	341	42	.	.	.
cord-343791-0vykwml5	342	1	[	[	-LRB-
cord-343791-0vykwml5	342	2	116	116	CD
cord-343791-0vykwml5	342	3	]	]	-RRB-
cord-343791-0vykwml5	343	1	A	a	DT
cord-343791-0vykwml5	343	2	related	related	JJ
cord-343791-0vykwml5	343	3	study	study	NN
cord-343791-0vykwml5	343	4	used	use	VBD
cord-343791-0vykwml5	343	5	a	a	DT
cord-343791-0vykwml5	343	6	modified	modify	VBN
cord-343791-0vykwml5	343	7	approach	approach	NN
cord-343791-0vykwml5	343	8	by	by	IN
cord-343791-0vykwml5	343	9	conjugating	conjugate	VBG
cord-343791-0vykwml5	343	10	a	a	DT
cord-343791-0vykwml5	343	11	streptavidin	streptavidin	NN
cord-343791-0vykwml5	343	12	-	-	HYPH
cord-343791-0vykwml5	343	13	linked	link	VBN
cord-343791-0vykwml5	343	14	fluorophore	fluorophore	NN
cord-343791-0vykwml5	343	15	to	to	IN
cord-343791-0vykwml5	343	16	phages	phage	NNS
cord-343791-0vykwml5	343	17	displaying	display	VBG
cord-343791-0vykwml5	343	18	tumortargeting	tumortargeting	NN
cord-343791-0vykwml5	343	19	and	and	CC
cord-343791-0vykwml5	343	20	streptavidin	streptavidin	NN
cord-343791-0vykwml5	343	21	-	-	HYPH
cord-343791-0vykwml5	343	22	binding	bind	VBG
cord-343791-0vykwml5	343	23	peptides	peptide	NNS
cord-343791-0vykwml5	343	24	on	on	IN
cord-343791-0vykwml5	343	25	their	-PRON-	PRP$
cord-343791-0vykwml5	343	26	surface	surface	NN
cord-343791-0vykwml5	343	27	for	for	IN
cord-343791-0vykwml5	343	28	targeted	target	VBN
cord-343791-0vykwml5	343	29	cancer	cancer	NN
cord-343791-0vykwml5	343	30	imaging	imaging	NN
cord-343791-0vykwml5	343	31	without	without	IN
cord-343791-0vykwml5	343	32	the	the	DT
cord-343791-0vykwml5	343	33	use	use	NN
cord-343791-0vykwml5	343	34	of	of	IN
cord-343791-0vykwml5	343	35	metal	metal	NN
cord-343791-0vykwml5	343	36	particles	particle	NNS
cord-343791-0vykwml5	343	37	.	.	.
cord-343791-0vykwml5	344	1	[	[	-LRB-
cord-343791-0vykwml5	344	2	15	15	CD
cord-343791-0vykwml5	344	3	]	]	-RRB-
cord-343791-0vykwml5	345	1	These	these	DT
cord-343791-0vykwml5	345	2	studies	study	NNS
cord-343791-0vykwml5	345	3	demonstrated	demonstrate	VBD
cord-343791-0vykwml5	345	4	the	the	DT
cord-343791-0vykwml5	345	5	importance	importance	NN
cord-343791-0vykwml5	345	6	of	of	IN
cord-343791-0vykwml5	345	7	directional	directional	JJ
cord-343791-0vykwml5	345	8	patterning	patterning	NN
cord-343791-0vykwml5	345	9	in	in	IN
cord-343791-0vykwml5	345	10	combination	combination	NN
cord-343791-0vykwml5	345	11	with	with	IN
cord-343791-0vykwml5	345	12	the	the	DT
cord-343791-0vykwml5	345	13	display	display	NN
cord-343791-0vykwml5	345	14	of	of	IN
cord-343791-0vykwml5	345	15	specific	specific	JJ
cord-343791-0vykwml5	345	16	peptides	peptide	NNS
cord-343791-0vykwml5	345	17	on	on	IN
cord-343791-0vykwml5	345	18	the	the	DT
cord-343791-0vykwml5	345	19	phages	phage	NNS
cord-343791-0vykwml5	345	20	.	.	.
cord-343791-0vykwml5	346	1	Moreover	moreover	RB
cord-343791-0vykwml5	346	2	,	,	,
cord-343791-0vykwml5	346	3	the	the	DT
cord-343791-0vykwml5	346	4	incorporation	incorporation	NN
cord-343791-0vykwml5	346	5	of	of	IN
cord-343791-0vykwml5	346	6	multiple	multiple	JJ
cord-343791-0vykwml5	346	7	bioactive	bioactive	JJ
cord-343791-0vykwml5	346	8	phage	phage	NN
cord-343791-0vykwml5	346	9	populations	population	NNS
cord-343791-0vykwml5	346	10	into	into	IN
cord-343791-0vykwml5	346	11	a	a	DT
cord-343791-0vykwml5	346	12	single	single	JJ
cord-343791-0vykwml5	346	13	material	material	NN
cord-343791-0vykwml5	346	14	only	only	RB
cord-343791-0vykwml5	346	15	requires	require	VBZ
cord-343791-0vykwml5	346	16	adjustment	adjustment	NN
cord-343791-0vykwml5	346	17	of	of	IN
cord-343791-0vykwml5	346	18	the	the	DT
cord-343791-0vykwml5	346	19	mixture	mixture	NN
cord-343791-0vykwml5	346	20	of	of	IN
cord-343791-0vykwml5	346	21	various	various	JJ
cord-343791-0vykwml5	346	22	deposited	deposit	VBN
cord-343791-0vykwml5	346	23	phages	phage	NNS
cord-343791-0vykwml5	346	24	,	,	,
cord-343791-0vykwml5	346	25	so	so	RB
cord-343791-0vykwml5	346	26	in	in	IN
cord-343791-0vykwml5	346	27	this	this	DT
cord-343791-0vykwml5	346	28	way	way	NN
cord-343791-0vykwml5	346	29	these	these	DT
cord-343791-0vykwml5	346	30	materials	material	NNS
cord-343791-0vykwml5	346	31	feature	feature	VBP
cord-343791-0vykwml5	346	32	the	the	DT
cord-343791-0vykwml5	346	33	modularity	modularity	NN
cord-343791-0vykwml5	346	34	characteristic	characteristic	NN
cord-343791-0vykwml5	346	35	of	of	IN
cord-343791-0vykwml5	346	36	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	346	37	systems	system	NNS
cord-343791-0vykwml5	346	38	.	.	.
cord-343791-0vykwml5	347	1	Similar	similar	JJ
cord-343791-0vykwml5	347	2	to	to	IN
cord-343791-0vykwml5	347	3	other	other	JJ
cord-343791-0vykwml5	347	4	nanofibrous	nanofibrous	JJ
cord-343791-0vykwml5	347	5	materials	material	NNS
cord-343791-0vykwml5	347	6	,	,	,
cord-343791-0vykwml5	347	7	filamentous	filamentous	JJ
cord-343791-0vykwml5	347	8	phage	phage	NN
cord-343791-0vykwml5	347	9	materials	material	NNS
cord-343791-0vykwml5	347	10	have	have	VBP
cord-343791-0vykwml5	347	11	received	receive	VBN
cord-343791-0vykwml5	347	12	significant	significant	JJ
cord-343791-0vykwml5	347	13	attention	attention	NN
cord-343791-0vykwml5	347	14	for	for	IN
cord-343791-0vykwml5	347	15	inducing	induce	VBG
cord-343791-0vykwml5	347	16	osteogenesis	osteogenesis	NN
cord-343791-0vykwml5	347	17	because	because	IN
cord-343791-0vykwml5	347	18	they	-PRON-	PRP
cord-343791-0vykwml5	347	19	can	can	MD
cord-343791-0vykwml5	347	20	form	form	VB
cord-343791-0vykwml5	347	21	collagen	collagen	NN
cord-343791-0vykwml5	347	22	-	-	HYPH
cord-343791-0vykwml5	347	23	mimetic	mimetic	NN
cord-343791-0vykwml5	347	24	bundles	bundle	NNS
cord-343791-0vykwml5	347	25	for	for	IN
cord-343791-0vykwml5	347	26	the	the	DT
cord-343791-0vykwml5	347	27	mineralization	mineralization	NN
cord-343791-0vykwml5	347	28	of	of	IN
cord-343791-0vykwml5	347	29	hydroxyapatite	hydroxyapatite	NN
cord-343791-0vykwml5	347	30	similarly	similarly	RB
cord-343791-0vykwml5	347	31	to	to	IN
cord-343791-0vykwml5	347	32	PA	PA	NNP
cord-343791-0vykwml5	347	33	and	and	CC
cord-343791-0vykwml5	347	34	β	β	NN
cord-343791-0vykwml5	347	35	-	-	HYPH
cord-343791-0vykwml5	347	36	sheet	sheet	NN
cord-343791-0vykwml5	347	37	peptide	peptide	NN
cord-343791-0vykwml5	347	38	nanofibers	nanofiber	NNS
cord-343791-0vykwml5	347	39	.	.	.
cord-343791-0vykwml5	348	1	Display	display	NN
cord-343791-0vykwml5	348	2	of	of	IN
cord-343791-0vykwml5	348	3	anioinic	anioinic	JJ
cord-343791-0vykwml5	348	4	peptides	peptide	NNS
cord-343791-0vykwml5	348	5	caused	cause	VBD
cord-343791-0vykwml5	348	6	parallel	parallel	JJ
cord-343791-0vykwml5	348	7	assembly	assembly	NN
cord-343791-0vykwml5	348	8	of	of	IN
cord-343791-0vykwml5	348	9	individual	individual	JJ
cord-343791-0vykwml5	348	10	phage	phage	NN
cord-343791-0vykwml5	348	11	in	in	IN
cord-343791-0vykwml5	348	12	the	the	DT
cord-343791-0vykwml5	348	13	presence	presence	NN
cord-343791-0vykwml5	348	14	of	of	IN
cord-343791-0vykwml5	348	15	cations	cation	NNS
cord-343791-0vykwml5	348	16	,	,	,
cord-343791-0vykwml5	348	17	followed	follow	VBN
cord-343791-0vykwml5	348	18	by	by	IN
cord-343791-0vykwml5	348	19	formation	formation	NN
cord-343791-0vykwml5	348	20	of	of	IN
cord-343791-0vykwml5	348	21	oriented	orient	VBN
cord-343791-0vykwml5	348	22	crystals	crystal	NNS
cord-343791-0vykwml5	348	23	when	when	WRB
cord-343791-0vykwml5	348	24	counterions	counterion	NNS
cord-343791-0vykwml5	348	25	were	be	VBD
cord-343791-0vykwml5	348	26	introduced	introduce	VBN
cord-343791-0vykwml5	348	27	owing	owe	VBG
cord-343791-0vykwml5	348	28	to	to	IN
cord-343791-0vykwml5	348	29	the	the	DT
cord-343791-0vykwml5	348	30	local	local	JJ
cord-343791-0vykwml5	348	31	supersaturation	supersaturation	NN
cord-343791-0vykwml5	348	32	of	of	IN
cord-343791-0vykwml5	348	33	inorganic	inorganic	JJ
cord-343791-0vykwml5	348	34	ions	ion	NNS
cord-343791-0vykwml5	348	35	.	.	.
cord-343791-0vykwml5	349	1	[	[	-LRB-
cord-343791-0vykwml5	349	2	117	117	CD
cord-343791-0vykwml5	349	3	]	]	-RRB-
cord-343791-0vykwml5	350	1	This	this	DT
cord-343791-0vykwml5	350	2	approach	approach	NN
cord-343791-0vykwml5	350	3	closely	closely	RB
cord-343791-0vykwml5	350	4	resembled	resemble	VBD
cord-343791-0vykwml5	350	5	the	the	DT
cord-343791-0vykwml5	350	6	demonstration	demonstration	NN
cord-343791-0vykwml5	350	7	of	of	IN
cord-343791-0vykwml5	350	8	PA	PA	NNP
cord-343791-0vykwml5	350	9	mineralization	mineralization	NN
cord-343791-0vykwml5	350	10	presented	present	VBN
cord-343791-0vykwml5	350	11	by	by	IN
cord-343791-0vykwml5	350	12	Stupp	Stupp	NNP
cord-343791-0vykwml5	350	13	and	and	CC
cord-343791-0vykwml5	350	14	coworkers	coworker	NNS
cord-343791-0vykwml5	350	15	and	and	CC
cord-343791-0vykwml5	350	16	illustrates	illustrate	VBZ
cord-343791-0vykwml5	350	17	conservation	conservation	NN
cord-343791-0vykwml5	350	18	of	of	IN
cord-343791-0vykwml5	350	19	biological	biological	JJ
cord-343791-0vykwml5	350	20	processes	process	NNS
cord-343791-0vykwml5	350	21	across	across	IN
cord-343791-0vykwml5	350	22	materials	material	NNS
cord-343791-0vykwml5	350	23	platforms	platform	NNS
cord-343791-0vykwml5	350	24	.	.	.
cord-343791-0vykwml5	351	1	[	[	-LRB-
cord-343791-0vykwml5	351	2	11	11	CD
cord-343791-0vykwml5	351	3	]	]	-RRB-
cord-343791-0vykwml5	352	1	Since	since	IN
cord-343791-0vykwml5	352	2	the	the	DT
cord-343791-0vykwml5	352	3	demonstration	demonstration	NN
cord-343791-0vykwml5	352	4	of	of	IN
cord-343791-0vykwml5	352	5	phage	phage	NN
cord-343791-0vykwml5	352	6	assembly	assembly	NN
cord-343791-0vykwml5	352	7	mineralization	mineralization	NN
cord-343791-0vykwml5	352	8	,	,	,
cord-343791-0vykwml5	352	9	osteogenesis	osteogenesis	NN
cord-343791-0vykwml5	352	10	studies	study	NNS
cord-343791-0vykwml5	352	11	have	have	VBP
cord-343791-0vykwml5	352	12	expanded	expand	VBN
cord-343791-0vykwml5	352	13	to	to	TO
cord-343791-0vykwml5	352	14	include	include	VB
cord-343791-0vykwml5	352	15	presentation	presentation	NN
cord-343791-0vykwml5	352	16	of	of	IN
cord-343791-0vykwml5	352	17	a	a	DT
cord-343791-0vykwml5	352	18	hydroxyapatite	hydroxyapatite	JJ
cord-343791-0vykwml5	352	19	nucleating	nucleate	VBG
cord-343791-0vykwml5	352	20	protein	protein	NN
cord-343791-0vykwml5	352	21	,	,	,
cord-343791-0vykwml5	352	22	Dentin	Dentin	NNP
cord-343791-0vykwml5	352	23	Matrix	Matrix	NNP
cord-343791-0vykwml5	352	24	Protein-1	Protein-1	NNP
cord-343791-0vykwml5	352	25	,	,	,
cord-343791-0vykwml5	352	26	as	as	IN
cord-343791-0vykwml5	352	27	an	an	DT
cord-343791-0vykwml5	352	28	alternative	alternative	JJ
cord-343791-0vykwml5	352	29	moiety	moiety	NN
cord-343791-0vykwml5	352	30	for	for	IN
cord-343791-0vykwml5	352	31	inducing	induce	VBG
cord-343791-0vykwml5	352	32	crystal	crystal	NN
cord-343791-0vykwml5	352	33	formation	formation	NN
cord-343791-0vykwml5	352	34	.	.	.
cord-343791-0vykwml5	353	1	[	[	-LRB-
cord-343791-0vykwml5	353	2	118	118	CD
cord-343791-0vykwml5	353	3	]	]	-RRB-
cord-343791-0vykwml5	353	4	Tobacco	tobacco	NN
cord-343791-0vykwml5	353	5	mosiac	mosiac	NN
cord-343791-0vykwml5	353	6	virus	virus	NN
cord-343791-0vykwml5	353	7	(	(	-LRB-
cord-343791-0vykwml5	353	8	TMV	TMV	NNP
cord-343791-0vykwml5	353	9	)	)	-RRB-
cord-343791-0vykwml5	353	10	,	,	,
cord-343791-0vykwml5	353	11	another	another	DT
cord-343791-0vykwml5	353	12	rod	rod	NN
cord-343791-0vykwml5	353	13	-	-	HYPH
cord-343791-0vykwml5	353	14	like	like	JJ
cord-343791-0vykwml5	353	15	virus	virus	NN
cord-343791-0vykwml5	353	16	was	be	VBD
cord-343791-0vykwml5	353	17	shown	show	VBN
cord-343791-0vykwml5	353	18	to	to	TO
cord-343791-0vykwml5	353	19	cause	cause	VB
cord-343791-0vykwml5	353	20	differentiation	differentiation	NN
cord-343791-0vykwml5	353	21	of	of	IN
cord-343791-0vykwml5	353	22	mesenchymal	mesenchymal	JJ
cord-343791-0vykwml5	353	23	stem	stem	NN
cord-343791-0vykwml5	353	24	cells	cell	NNS
cord-343791-0vykwml5	353	25	into	into	IN
cord-343791-0vykwml5	353	26	bone	bone	NN
cord-343791-0vykwml5	353	27	cells	cell	NNS
cord-343791-0vykwml5	353	28	as	as	IN
cord-343791-0vykwml5	353	29	culture	culture	NN
cord-343791-0vykwml5	353	30	on	on	IN
cord-343791-0vykwml5	353	31	the	the	DT
cord-343791-0vykwml5	353	32	TMV	TMV	NNP
cord-343791-0vykwml5	353	33	coated	coat	VBN
cord-343791-0vykwml5	353	34	substrate	substrate	NN
cord-343791-0vykwml5	353	35	caused	cause	VBD
cord-343791-0vykwml5	353	36	an	an	DT
cord-343791-0vykwml5	353	37	upregulation	upregulation	NN
cord-343791-0vykwml5	353	38	of	of	IN
cord-343791-0vykwml5	353	39	BMP-2	BMP-2	NNP
cord-343791-0vykwml5	353	40	,	,	,
cord-343791-0vykwml5	353	41	osteocalcin	osteocalcin	NN
cord-343791-0vykwml5	353	42	,	,	,
cord-343791-0vykwml5	353	43	and	and	CC
cord-343791-0vykwml5	353	44	calcium	calcium	NN
cord-343791-0vykwml5	353	45	sequestration	sequestration	NN
cord-343791-0vykwml5	353	46	,	,	,
cord-343791-0vykwml5	353	47	which	which	WDT
cord-343791-0vykwml5	353	48	are	be	VBP
cord-343791-0vykwml5	353	49	all	all	DT
cord-343791-0vykwml5	353	50	markers	marker	NNS
cord-343791-0vykwml5	353	51	of	of	IN
cord-343791-0vykwml5	353	52	bone	bone	NN
cord-343791-0vykwml5	353	53	development	development	NN
cord-343791-0vykwml5	353	54	.	.	.
cord-343791-0vykwml5	354	1	[	[	-LRB-
cord-343791-0vykwml5	354	2	119	119	CD
cord-343791-0vykwml5	354	3	]	]	-RRB-
cord-343791-0vykwml5	355	1	Recently	recently	RB
cord-343791-0vykwml5	355	2	,	,	,
cord-343791-0vykwml5	355	3	RGD	RGD	NNP
cord-343791-0vykwml5	355	4	-	-	HYPH
cord-343791-0vykwml5	355	5	bearing	bear	VBG
cord-343791-0vykwml5	355	6	phages	phage	NNS
cord-343791-0vykwml5	355	7	were	be	VBD
cord-343791-0vykwml5	355	8	3D	3d	JJ
cord-343791-0vykwml5	355	9	-	-	HYPH
cord-343791-0vykwml5	355	10	printed	print	VBN
cord-343791-0vykwml5	355	11	into	into	IN
cord-343791-0vykwml5	355	12	a	a	DT
cord-343791-0vykwml5	355	13	ceramic	ceramic	JJ
cord-343791-0vykwml5	355	14	scaffold	scaffold	NN
cord-343791-0vykwml5	355	15	to	to	TO
cord-343791-0vykwml5	355	16	induce	induce	VB
cord-343791-0vykwml5	355	17	osteogenesis	osteogenesis	NN
cord-343791-0vykwml5	355	18	and	and	CC
cord-343791-0vykwml5	355	19	angiogenesis	angiogenesis	NN
cord-343791-0vykwml5	355	20	concurrently	concurrently	RB
cord-343791-0vykwml5	355	21	without	without	IN
cord-343791-0vykwml5	355	22	the	the	DT
cord-343791-0vykwml5	355	23	addition	addition	NN
cord-343791-0vykwml5	355	24	of	of	IN
cord-343791-0vykwml5	355	25	exogenous	exogenous	JJ
cord-343791-0vykwml5	355	26	vascular	vascular	JJ
cord-343791-0vykwml5	355	27	endothelial	endothelial	JJ
cord-343791-0vykwml5	355	28	growth	growth	NN
cord-343791-0vykwml5	355	29	factor	factor	NN
cord-343791-0vykwml5	355	30	.	.	.
cord-343791-0vykwml5	356	1	[	[	-LRB-
cord-343791-0vykwml5	356	2	16	16	CD
cord-343791-0vykwml5	356	3	]	]	-RRB-
cord-343791-0vykwml5	357	1	Because	because	IN
cord-343791-0vykwml5	357	2	of	of	IN
cord-343791-0vykwml5	357	3	the	the	DT
cord-343791-0vykwml5	357	4	scale	scale	NN
cord-343791-0vykwml5	357	5	at	at	IN
cord-343791-0vykwml5	357	6	which	which	WDT
cord-343791-0vykwml5	357	7	phage	phage	NN
cord-343791-0vykwml5	357	8	can	can	MD
cord-343791-0vykwml5	357	9	be	be	VB
cord-343791-0vykwml5	357	10	produced	produce	VBN
cord-343791-0vykwml5	357	11	,	,	,
cord-343791-0vykwml5	357	12	they	-PRON-	PRP
cord-343791-0vykwml5	357	13	may	may	MD
cord-343791-0vykwml5	357	14	have	have	VB
cord-343791-0vykwml5	357	15	manufacturing	manufacture	VBG
cord-343791-0vykwml5	357	16	advantages	advantage	NNS
cord-343791-0vykwml5	357	17	over	over	IN
cord-343791-0vykwml5	357	18	other	other	JJ
cord-343791-0vykwml5	357	19	designer	designer	NN
cord-343791-0vykwml5	357	20	materials	material	NNS
cord-343791-0vykwml5	357	21	.	.	.
cord-343791-0vykwml5	358	1	Over	over	IN
cord-343791-0vykwml5	358	2	the	the	DT
cord-343791-0vykwml5	358	3	past	past	JJ
cord-343791-0vykwml5	358	4	50	50	CD
cord-343791-0vykwml5	358	5	years	year	NNS
cord-343791-0vykwml5	358	6	,	,	,
cord-343791-0vykwml5	358	7	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	358	8	assemblies	assembly	NNS
cord-343791-0vykwml5	358	9	of	of	IN
cord-343791-0vykwml5	358	10	peptides	peptide	NNS
cord-343791-0vykwml5	358	11	and	and	CC
cord-343791-0vykwml5	358	12	proteins	protein	NNS
cord-343791-0vykwml5	358	13	have	have	VBP
cord-343791-0vykwml5	358	14	developed	develop	VBN
cord-343791-0vykwml5	358	15	from	from	IN
cord-343791-0vykwml5	358	16	single	single	JJ
cord-343791-0vykwml5	358	17	vaccines	vaccine	NNS
cord-343791-0vykwml5	358	18	to	to	IN
cord-343791-0vykwml5	358	19	a	a	DT
cord-343791-0vykwml5	358	20	broad	broad	JJ
cord-343791-0vykwml5	358	21	range	range	NN
cord-343791-0vykwml5	358	22	of	of	IN
cord-343791-0vykwml5	358	23	technologies	technology	NNS
cord-343791-0vykwml5	358	24	that	that	WDT
cord-343791-0vykwml5	358	25	spans	span	VBZ
cord-343791-0vykwml5	358	26	the	the	DT
cord-343791-0vykwml5	358	27	breadth	breadth	NN
cord-343791-0vykwml5	358	28	of	of	IN
cord-343791-0vykwml5	358	29	biomaterials	biomaterial	NNS
cord-343791-0vykwml5	358	30	applications	application	NNS
cord-343791-0vykwml5	358	31	as	as	IN
cord-343791-0vykwml5	358	32	drug	drug	NN
cord-343791-0vykwml5	358	33	delivery	delivery	NN
cord-343791-0vykwml5	358	34	vehicles	vehicle	NNS
cord-343791-0vykwml5	358	35	,	,	,
cord-343791-0vykwml5	358	36	scaffolds	scaffold	NNS
cord-343791-0vykwml5	358	37	for	for	IN
cord-343791-0vykwml5	358	38	tissue	tissue	NN
cord-343791-0vykwml5	358	39	regeneration	regeneration	NN
cord-343791-0vykwml5	358	40	,	,	,
cord-343791-0vykwml5	358	41	and	and	CC
cord-343791-0vykwml5	358	42	other	other	JJ
cord-343791-0vykwml5	358	43	therapeutics	therapeutic	NNS
cord-343791-0vykwml5	358	44	.	.	.
cord-343791-0vykwml5	359	1	[	[	-LRB-
cord-343791-0vykwml5	359	2	1	1	CD
cord-343791-0vykwml5	359	3	,	,	,
cord-343791-0vykwml5	359	4	2	2	CD
cord-343791-0vykwml5	359	5	,	,	,
cord-343791-0vykwml5	359	6	5	5	CD
cord-343791-0vykwml5	359	7	,	,	,
cord-343791-0vykwml5	359	8	6	6	CD
cord-343791-0vykwml5	359	9	]	]	-RRB-
cord-343791-0vykwml5	360	1	Currently	currently	RB
cord-343791-0vykwml5	360	2	,	,	,
cord-343791-0vykwml5	360	3	several	several	JJ
cord-343791-0vykwml5	360	4	have	have	VBP
cord-343791-0vykwml5	360	5	achieved	achieve	VBN
cord-343791-0vykwml5	360	6	regulatory	regulatory	JJ
cord-343791-0vykwml5	360	7	approval	approval	NN
cord-343791-0vykwml5	360	8	for	for	IN
cord-343791-0vykwml5	360	9	clinical	clinical	JJ
cord-343791-0vykwml5	360	10	use	use	NN
cord-343791-0vykwml5	360	11	(	(	-LRB-
cord-343791-0vykwml5	360	12	Table	table	NN
cord-343791-0vykwml5	360	13	1	1	CD
cord-343791-0vykwml5	360	14	)	)	-RRB-
cord-343791-0vykwml5	360	15	,	,	,
cord-343791-0vykwml5	360	16	primarily	primarily	RB
cord-343791-0vykwml5	360	17	in	in	IN
cord-343791-0vykwml5	360	18	the	the	DT
cord-343791-0vykwml5	360	19	vaccine	vaccine	NN
cord-343791-0vykwml5	360	20	space	space	NN
cord-343791-0vykwml5	360	21	.	.	.
cord-343791-0vykwml5	361	1	The	the	DT
cord-343791-0vykwml5	361	2	advancement	advancement	NN
cord-343791-0vykwml5	361	3	of	of	IN
cord-343791-0vykwml5	361	4	these	these	DT
cord-343791-0vykwml5	361	5	platforms	platform	NNS
cord-343791-0vykwml5	361	6	can	can	MD
cord-343791-0vykwml5	361	7	be	be	VB
cord-343791-0vykwml5	361	8	attributed	attribute	VBN
cord-343791-0vykwml5	361	9	to	to	IN
cord-343791-0vykwml5	361	10	many	many	JJ
cord-343791-0vykwml5	361	11	factors	factor	NNS
cord-343791-0vykwml5	361	12	.	.	.
cord-343791-0vykwml5	362	1	Peptides	peptide	NNS
cord-343791-0vykwml5	362	2	and	and	CC
cord-343791-0vykwml5	362	3	proteins	protein	NNS
cord-343791-0vykwml5	362	4	are	be	VBP
cord-343791-0vykwml5	362	5	more	more	RBR
cord-343791-0vykwml5	362	6	economical	economical	JJ
cord-343791-0vykwml5	362	7	than	than	IN
cord-343791-0vykwml5	362	8	ever	ever	RB
cord-343791-0vykwml5	362	9	to	to	TO
cord-343791-0vykwml5	362	10	produce	produce	VB
cord-343791-0vykwml5	362	11	,	,	,
cord-343791-0vykwml5	362	12	and	and	CC
cord-343791-0vykwml5	362	13	manufacturing	manufacturing	NN
cord-343791-0vykwml5	362	14	efficiencies	efficiency	NNS
cord-343791-0vykwml5	362	15	continue	continue	VBP
cord-343791-0vykwml5	362	16	to	to	TO
cord-343791-0vykwml5	362	17	be	be	VB
cord-343791-0vykwml5	362	18	developed	develop	VBN
cord-343791-0vykwml5	362	19	.	.	.
cord-343791-0vykwml5	363	1	The	the	DT
cord-343791-0vykwml5	363	2	design	design	NN
cord-343791-0vykwml5	363	3	rules	rule	VBZ
cord-343791-0vykwml5	363	4	for	for	IN
cord-343791-0vykwml5	363	5	each	each	DT
cord-343791-0vykwml5	363	6	subclass	subclass	NN
cord-343791-0vykwml5	363	7	of	of	IN
cord-343791-0vykwml5	363	8	materials	material	NNS
cord-343791-0vykwml5	363	9	has	have	VBZ
cord-343791-0vykwml5	363	10	been	be	VBN
cord-343791-0vykwml5	363	11	significantly	significantly	RB
cord-343791-0vykwml5	363	12	mapped	map	VBN
cord-343791-0vykwml5	363	13	in	in	IN
cord-343791-0vykwml5	363	14	recent	recent	JJ
cord-343791-0vykwml5	363	15	years	year	NNS
cord-343791-0vykwml5	363	16	.	.	.
cord-343791-0vykwml5	364	1	And	and	CC
cord-343791-0vykwml5	364	2	strategies	strategy	NNS
cord-343791-0vykwml5	364	3	have	have	VBP
cord-343791-0vykwml5	364	4	been	be	VBN
cord-343791-0vykwml5	364	5	optimized	optimize	VBN
cord-343791-0vykwml5	364	6	for	for	IN
cord-343791-0vykwml5	364	7	incorporating	incorporate	VBG
cord-343791-0vykwml5	364	8	disease	disease	NN
cord-343791-0vykwml5	364	9	-	-	HYPH
cord-343791-0vykwml5	364	10	specific	specific	JJ
cord-343791-0vykwml5	364	11	ligands	ligand	NNS
cord-343791-0vykwml5	364	12	,	,	,
cord-343791-0vykwml5	364	13	epitopes	epitope	NNS
cord-343791-0vykwml5	364	14	,	,	,
cord-343791-0vykwml5	364	15	or	or	CC
cord-343791-0vykwml5	364	16	other	other	JJ
cord-343791-0vykwml5	364	17	moieties	moiety	NNS
cord-343791-0vykwml5	364	18	within	within	IN
cord-343791-0vykwml5	364	19	each	each	DT
cord-343791-0vykwml5	364	20	platform	platform	NN
cord-343791-0vykwml5	364	21	.	.	.
cord-343791-0vykwml5	365	1	We	-PRON-	PRP
cord-343791-0vykwml5	365	2	expect	expect	VBP
cord-343791-0vykwml5	365	3	the	the	DT
cord-343791-0vykwml5	365	4	coming	come	VBG
cord-343791-0vykwml5	365	5	decades	decade	NNS
cord-343791-0vykwml5	365	6	to	to	TO
cord-343791-0vykwml5	365	7	witness	witness	VB
cord-343791-0vykwml5	365	8	the	the	DT
cord-343791-0vykwml5	365	9	implementation	implementation	NN
cord-343791-0vykwml5	365	10	of	of	IN
cord-343791-0vykwml5	365	11	many	many	JJ
cord-343791-0vykwml5	365	12	new	new	JJ
cord-343791-0vykwml5	365	13	examples	example	NNS
cord-343791-0vykwml5	365	14	of	of	IN
cord-343791-0vykwml5	365	15	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	365	16	polypeptide	polypeptide	NN
cord-343791-0vykwml5	365	17	therapies	therapy	NNS
cord-343791-0vykwml5	365	18	.	.	.
cord-343791-0vykwml5	366	1	The	the	DT
cord-343791-0vykwml5	366	2	immunogenic	immunogenic	JJ
cord-343791-0vykwml5	366	3	features	feature	NNS
cord-343791-0vykwml5	366	4	of	of	IN
cord-343791-0vykwml5	366	5	peptide	peptide	NN
cord-343791-0vykwml5	366	6	assemblies	assembly	NNS
cord-343791-0vykwml5	366	7	are	be	VBP
cord-343791-0vykwml5	366	8	advantageous	advantageous	JJ
cord-343791-0vykwml5	366	9	for	for	IN
cord-343791-0vykwml5	366	10	the	the	DT
cord-343791-0vykwml5	366	11	development	development	NN
cord-343791-0vykwml5	366	12	of	of	IN
cord-343791-0vykwml5	366	13	synthetic	synthetic	JJ
cord-343791-0vykwml5	366	14	vaccines	vaccine	NNS
cord-343791-0vykwml5	366	15	and	and	CC
cord-343791-0vykwml5	366	16	other	other	JJ
cord-343791-0vykwml5	366	17	engineered	engineer	VBN
cord-343791-0vykwml5	366	18	immunotherapies	immunotherapy	NNS
cord-343791-0vykwml5	366	19	,	,	,
cord-343791-0vykwml5	366	20	a	a	DT
cord-343791-0vykwml5	366	21	topic	topic	NN
cord-343791-0vykwml5	366	22	which	which	WDT
cord-343791-0vykwml5	366	23	has	have	VBZ
cord-343791-0vykwml5	366	24	been	be	VBN
cord-343791-0vykwml5	366	25	recently	recently	RB
cord-343791-0vykwml5	366	26	reviewed	review	VBN
cord-343791-0vykwml5	366	27	by	by	IN
cord-343791-0vykwml5	366	28	our	-PRON-	PRP$
cord-343791-0vykwml5	366	29	group	group	NN
cord-343791-0vykwml5	366	30	and	and	CC
cord-343791-0vykwml5	366	31	others	other	NNS
cord-343791-0vykwml5	366	32	,	,	,
cord-343791-0vykwml5	366	33	[	[	-LRB-
cord-343791-0vykwml5	366	34	1	1	CD
cord-343791-0vykwml5	366	35	,	,	,
cord-343791-0vykwml5	366	36	2	2	CD
cord-343791-0vykwml5	366	37	,	,	,
cord-343791-0vykwml5	366	38	5	5	CD
cord-343791-0vykwml5	366	39	,	,	,
cord-343791-0vykwml5	366	40	82	82	CD
cord-343791-0vykwml5	366	41	,	,	,
cord-343791-0vykwml5	366	42	83	83	CD
cord-343791-0vykwml5	366	43	]	]	-RRB-
cord-343791-0vykwml5	366	44	but	but	CC
cord-343791-0vykwml5	366	45	it	-PRON-	PRP
cord-343791-0vykwml5	366	46	is	be	VBZ
cord-343791-0vykwml5	366	47	also	also	RB
cord-343791-0vykwml5	366	48	important	important	JJ
cord-343791-0vykwml5	366	49	to	to	TO
cord-343791-0vykwml5	366	50	note	note	VB
cord-343791-0vykwml5	366	51	for	for	IN
cord-343791-0vykwml5	366	52	other	other	JJ
cord-343791-0vykwml5	366	53	assemblies	assembly	NNS
cord-343791-0vykwml5	366	54	containing	contain	VBG
cord-343791-0vykwml5	366	55	high	high	JJ
cord-343791-0vykwml5	366	56	densities	density	NNS
cord-343791-0vykwml5	366	57	of	of	IN
cord-343791-0vykwml5	366	58	protein	protein	NN
cord-343791-0vykwml5	366	59	or	or	CC
cord-343791-0vykwml5	366	60	peptide	peptide	NN
cord-343791-0vykwml5	366	61	ligands	ligand	NNS
cord-343791-0vykwml5	366	62	/	/	SYM
cord-343791-0vykwml5	366	63	epitopes	epitope	NNS
cord-343791-0vykwml5	366	64	that	that	IN
cord-343791-0vykwml5	366	65	such	such	JJ
cord-343791-0vykwml5	366	66	multivalent	multivalent	JJ
cord-343791-0vykwml5	366	67	displays	display	NNS
cord-343791-0vykwml5	366	68	may	may	MD
cord-343791-0vykwml5	366	69	induce	induce	VB
cord-343791-0vykwml5	366	70	unwanted	unwanted	JJ
cord-343791-0vykwml5	366	71	immune	immune	JJ
cord-343791-0vykwml5	366	72	responses	response	NNS
cord-343791-0vykwml5	366	73	.	.	.
cord-343791-0vykwml5	367	1	It	-PRON-	PRP
cord-343791-0vykwml5	367	2	remains	remain	VBZ
cord-343791-0vykwml5	367	3	to	to	TO
cord-343791-0vykwml5	367	4	be	be	VB
cord-343791-0vykwml5	367	5	seen	see	VBN
cord-343791-0vykwml5	367	6	whether	whether	IN
cord-343791-0vykwml5	367	7	such	such	JJ
cord-343791-0vykwml5	367	8	responses	response	NNS
cord-343791-0vykwml5	367	9	can	can	MD
cord-343791-0vykwml5	367	10	be	be	VB
cord-343791-0vykwml5	367	11	tolerated	tolerate	VBN
cord-343791-0vykwml5	367	12	in	in	IN
cord-343791-0vykwml5	367	13	specific	specific	JJ
cord-343791-0vykwml5	367	14	applications	application	NNS
cord-343791-0vykwml5	367	15	,	,	,
cord-343791-0vykwml5	367	16	or	or	CC
cord-343791-0vykwml5	367	17	if	if	IN
cord-343791-0vykwml5	367	18	they	-PRON-	PRP
cord-343791-0vykwml5	367	19	could	could	MD
cord-343791-0vykwml5	367	20	even	even	RB
cord-343791-0vykwml5	367	21	be	be	VB
cord-343791-0vykwml5	367	22	turned	turn	VBN
cord-343791-0vykwml5	367	23	in	in	RP
cord-343791-0vykwml5	367	24	the	the	DT
cord-343791-0vykwml5	367	25	favor	favor	NN
cord-343791-0vykwml5	367	26	of	of	IN
cord-343791-0vykwml5	367	27	the	the	DT
cord-343791-0vykwml5	367	28	material	material	NN
cord-343791-0vykwml5	367	29	's	's	POS
cord-343791-0vykwml5	367	30	clinical	clinical	JJ
cord-343791-0vykwml5	367	31	performance	performance	NN
cord-343791-0vykwml5	367	32	.	.	.
cord-343791-0vykwml5	368	1	Interestingly	interestingly	RB
cord-343791-0vykwml5	368	2	,	,	,
cord-343791-0vykwml5	368	3	neither	neither	CC
cord-343791-0vykwml5	368	4	Curodont	Curodont	NNP
cord-343791-0vykwml5	368	5	[	[	-LRB-
cord-343791-0vykwml5	368	6	78	78	CD
cord-343791-0vykwml5	368	7	]	]	-RRB-
cord-343791-0vykwml5	368	8	nor	nor	CC
cord-343791-0vykwml5	368	9	Purastat	purastat	JJ
cord-343791-0vykwml5	368	10	[	[	-LRB-
cord-343791-0vykwml5	368	11	67	67	CD
cord-343791-0vykwml5	368	12	]	]	-RRB-
cord-343791-0vykwml5	368	13	contain	contain	VBP
cord-343791-0vykwml5	368	14	specific	specific	JJ
cord-343791-0vykwml5	368	15	ligands	ligand	NNS
cord-343791-0vykwml5	368	16	/	/	SYM
cord-343791-0vykwml5	368	17	epitopes	epitope	NNS
cord-343791-0vykwml5	368	18	,	,	,
cord-343791-0vykwml5	368	19	possibly	possibly	RB
cord-343791-0vykwml5	368	20	avoiding	avoid	VBG
cord-343791-0vykwml5	368	21	immunogenicity	immunogenicity	NN
cord-343791-0vykwml5	368	22	that	that	WDT
cord-343791-0vykwml5	368	23	may	may	MD
cord-343791-0vykwml5	368	24	be	be	VB
cord-343791-0vykwml5	368	25	observed	observe	VBN
cord-343791-0vykwml5	368	26	in	in	IN
cord-343791-0vykwml5	368	27	trials	trial	NNS
cord-343791-0vykwml5	368	28	of	of	IN
cord-343791-0vykwml5	368	29	other	other	JJ
cord-343791-0vykwml5	368	30	nanofibrous	nanofibrous	JJ
cord-343791-0vykwml5	368	31	materials	material	NNS
cord-343791-0vykwml5	368	32	containing	contain	VBG
cord-343791-0vykwml5	368	33	additional	additional	JJ
cord-343791-0vykwml5	368	34	protein	protein	NN
cord-343791-0vykwml5	368	35	or	or	CC
cord-343791-0vykwml5	368	36	peptide	peptide	JJ
cord-343791-0vykwml5	368	37	functional	functional	JJ
cord-343791-0vykwml5	368	38	components	component	NNS
cord-343791-0vykwml5	368	39	.	.	.
cord-343791-0vykwml5	369	1	Additional	additional	JJ
cord-343791-0vykwml5	369	2	future	future	JJ
cord-343791-0vykwml5	369	3	work	work	NN
cord-343791-0vykwml5	369	4	may	may	MD
cord-343791-0vykwml5	369	5	focus	focus	VB
cord-343791-0vykwml5	369	6	on	on	IN
cord-343791-0vykwml5	369	7	investigating	investigate	VBG
cord-343791-0vykwml5	369	8	the	the	DT
cord-343791-0vykwml5	369	9	biodistribution	biodistribution	NN
cord-343791-0vykwml5	369	10	and	and	CC
cord-343791-0vykwml5	369	11	pharmacokinetics	pharmacokinetic	NNS
cord-343791-0vykwml5	369	12	of	of	IN
cord-343791-0vykwml5	369	13	preclinical	preclinical	JJ
cord-343791-0vykwml5	369	14	self	self	NN
cord-343791-0vykwml5	369	15	-	-	HYPH
cord-343791-0vykwml5	369	16	assembling	assemble	VBG
cord-343791-0vykwml5	369	17	materials	material	NNS
cord-343791-0vykwml5	369	18	.	.	.
cord-343791-0vykwml5	370	1	Due	due	IN
cord-343791-0vykwml5	370	2	to	to	IN
cord-343791-0vykwml5	370	3	the	the	DT
cord-343791-0vykwml5	370	4	dynamic	dynamic	JJ
cord-343791-0vykwml5	370	5	nature	nature	NN
cord-343791-0vykwml5	370	6	of	of	IN
cord-343791-0vykwml5	370	7	these	these	DT
cord-343791-0vykwml5	370	8	materials	material	NNS
cord-343791-0vykwml5	370	9	,	,	,
cord-343791-0vykwml5	370	10	it	-PRON-	PRP
cord-343791-0vykwml5	370	11	is	be	VBZ
cord-343791-0vykwml5	370	12	important	important	JJ
cord-343791-0vykwml5	370	13	to	to	TO
cord-343791-0vykwml5	370	14	understand	understand	VB
cord-343791-0vykwml5	370	15	how	how	WRB
cord-343791-0vykwml5	370	16	the	the	DT
cord-343791-0vykwml5	370	17	in	in	IN
cord-343791-0vykwml5	370	18	vivo	vivo	NN
cord-343791-0vykwml5	370	19	environment	environment	NN
cord-343791-0vykwml5	370	20	affects	affect	VBZ
cord-343791-0vykwml5	370	21	their	-PRON-	PRP$
cord-343791-0vykwml5	370	22	long	long	JJ
cord-343791-0vykwml5	370	23	-	-	HYPH
cord-343791-0vykwml5	370	24	term	term	NN
cord-343791-0vykwml5	370	25	structural	structural	JJ
cord-343791-0vykwml5	370	26	organization	organization	NN
cord-343791-0vykwml5	370	27	,	,	,
cord-343791-0vykwml5	370	28	retention	retention	NN
cord-343791-0vykwml5	370	29	,	,	,
cord-343791-0vykwml5	370	30	and	and	CC
cord-343791-0vykwml5	370	31	clearance	clearance	NN
cord-343791-0vykwml5	370	32	.	.	.
cord-343791-0vykwml5	371	1	In	in	IN
cord-343791-0vykwml5	371	2	order	order	NN
cord-343791-0vykwml5	371	3	to	to	TO
cord-343791-0vykwml5	371	4	be	be	VB
cord-343791-0vykwml5	371	5	clinically	clinically	RB
cord-343791-0vykwml5	371	6	translated	translate	VBN
cord-343791-0vykwml5	371	7	,	,	,
cord-343791-0vykwml5	371	8	these	these	DT
cord-343791-0vykwml5	371	9	platforms	platform	NNS
cord-343791-0vykwml5	371	10	must	must	MD
cord-343791-0vykwml5	371	11	also	also	RB
cord-343791-0vykwml5	371	12	be	be	VB
cord-343791-0vykwml5	371	13	capable	capable	JJ
cord-343791-0vykwml5	371	14	of	of	IN
cord-343791-0vykwml5	371	15	large	large	JJ
cord-343791-0vykwml5	371	16	-	-	HYPH
cord-343791-0vykwml5	371	17	scale	scale	NN
cord-343791-0vykwml5	371	18	production	production	NN
cord-343791-0vykwml5	371	19	and	and	CC
cord-343791-0vykwml5	371	20	stable	stable	JJ
cord-343791-0vykwml5	371	21	storage	storage	NN
cord-343791-0vykwml5	371	22	.	.	.
cord-343791-0vykwml5	372	1	Unlike	unlike	IN
cord-343791-0vykwml5	372	2	traditional	traditional	JJ
cord-343791-0vykwml5	372	3	small	small	JJ
cord-343791-0vykwml5	372	4	molecules	molecule	NNS
cord-343791-0vykwml5	372	5	,	,	,
cord-343791-0vykwml5	372	6	these	these	DT
cord-343791-0vykwml5	372	7	materials	material	NNS
cord-343791-0vykwml5	372	8	must	must	MD
cord-343791-0vykwml5	372	9	generally	generally	RB
cord-343791-0vykwml5	372	10	be	be	VB
cord-343791-0vykwml5	372	11	kept	keep	VBN
cord-343791-0vykwml5	372	12	in	in	IN
cord-343791-0vykwml5	372	13	monomeric	monomeric	JJ
cord-343791-0vykwml5	372	14	or	or	CC
cord-343791-0vykwml5	372	15	otherwise	otherwise	RB
cord-343791-0vykwml5	372	16	stable	stable	JJ
cord-343791-0vykwml5	372	17	states	state	NNS
cord-343791-0vykwml5	372	18	of	of	IN
cord-343791-0vykwml5	372	19	assembly	assembly	NN
cord-343791-0vykwml5	372	20	prior	prior	RB
cord-343791-0vykwml5	372	21	to	to	IN
cord-343791-0vykwml5	372	22	administration	administration	NN
cord-343791-0vykwml5	372	23	.	.	.
cord-343791-0vykwml5	373	1	Each	each	DT
cord-343791-0vykwml5	373	2	of	of	IN
cord-343791-0vykwml5	373	3	these	these	DT
cord-343791-0vykwml5	373	4	issues	issue	NNS
cord-343791-0vykwml5	373	5	represents	represent	VBZ
cord-343791-0vykwml5	373	6	important	important	JJ
cord-343791-0vykwml5	373	7	considerations	consideration	NNS
cord-343791-0vykwml5	373	8	that	that	WDT
cord-343791-0vykwml5	373	9	have	have	VBP
cord-343791-0vykwml5	373	10	not	not	RB
cord-343791-0vykwml5	373	11	yet	yet	RB
cord-343791-0vykwml5	373	12	been	be	VBN
cord-343791-0vykwml5	373	13	fully	fully	RB
cord-343791-0vykwml5	373	14	worked	work	VBN
cord-343791-0vykwml5	373	15	out	out	RP
cord-343791-0vykwml5	373	16	for	for	IN
cord-343791-0vykwml5	373	17	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	373	18	materials	material	NNS
cord-343791-0vykwml5	373	19	.	.	.
cord-343791-0vykwml5	374	1	With	with	IN
cord-343791-0vykwml5	374	2	several	several	JJ
cord-343791-0vykwml5	374	3	self	self	NN
cord-343791-0vykwml5	374	4	-	-	HYPH
cord-343791-0vykwml5	374	5	assembling	assemble	VBG
cord-343791-0vykwml5	374	6	platforms	platform	NNS
cord-343791-0vykwml5	374	7	being	be	VBG
cord-343791-0vykwml5	374	8	discovered	discover	VBN
cord-343791-0vykwml5	374	9	and	and	CC
cord-343791-0vykwml5	374	10	developed	develop	VBN
cord-343791-0vykwml5	374	11	over	over	IN
cord-343791-0vykwml5	374	12	the	the	DT
cord-343791-0vykwml5	374	13	past	past	JJ
cord-343791-0vykwml5	374	14	50	50	CD
cord-343791-0vykwml5	374	15	years	year	NNS
cord-343791-0vykwml5	374	16	,	,	,
cord-343791-0vykwml5	374	17	it	-PRON-	PRP
cord-343791-0vykwml5	374	18	is	be	VBZ
cord-343791-0vykwml5	374	19	worth	worth	JJ
cord-343791-0vykwml5	374	20	considering	consider	VBG
cord-343791-0vykwml5	374	21	the	the	DT
cord-343791-0vykwml5	374	22	cross	cross	NN
cord-343791-0vykwml5	374	23	-	-	NNS
cord-343791-0vykwml5	374	24	roads	road	NNS
cord-343791-0vykwml5	374	25	that	that	WDT
cord-343791-0vykwml5	374	26	lay	lie	VBD
cord-343791-0vykwml5	374	27	ahead	ahead	RB
cord-343791-0vykwml5	374	28	:	:	:
cord-343791-0vykwml5	374	29	should	should	MD
cord-343791-0vykwml5	374	30	we	-PRON-	PRP
cord-343791-0vykwml5	374	31	focus	focus	VB
cord-343791-0vykwml5	374	32	on	on	IN
cord-343791-0vykwml5	374	33	the	the	DT
cord-343791-0vykwml5	374	34	development	development	NN
cord-343791-0vykwml5	374	35	of	of	IN
cord-343791-0vykwml5	374	36	the	the	DT
cord-343791-0vykwml5	374	37	promising	promising	JJ
cord-343791-0vykwml5	374	38	platforms	platform	NNS
cord-343791-0vykwml5	374	39	discussed	discuss	VBN
cord-343791-0vykwml5	374	40	here	here	RB
cord-343791-0vykwml5	374	41	,	,	,
cord-343791-0vykwml5	374	42	or	or	CC
cord-343791-0vykwml5	374	43	should	should	MD
cord-343791-0vykwml5	374	44	we	-PRON-	PRP
cord-343791-0vykwml5	374	45	continue	continue	VB
cord-343791-0vykwml5	374	46	searching	search	VBG
cord-343791-0vykwml5	374	47	for	for	IN
cord-343791-0vykwml5	374	48	new	new	JJ
cord-343791-0vykwml5	374	49	,	,	,
cord-343791-0vykwml5	374	50	novel	novel	JJ
cord-343791-0vykwml5	374	51	platforms	platform	NNS
cord-343791-0vykwml5	374	52	?	?	.
cord-343791-0vykwml5	375	1	On	on	IN
cord-343791-0vykwml5	375	2	the	the	DT
cord-343791-0vykwml5	375	3	one	one	CD
cord-343791-0vykwml5	375	4	hand	hand	NN
cord-343791-0vykwml5	375	5	,	,	,
cord-343791-0vykwml5	375	6	several	several	JJ
cord-343791-0vykwml5	375	7	of	of	IN
cord-343791-0vykwml5	375	8	the	the	DT
cord-343791-0vykwml5	375	9	aforementioned	aforementioned	JJ
cord-343791-0vykwml5	375	10	platforms	platform	NNS
cord-343791-0vykwml5	375	11	have	have	VBP
cord-343791-0vykwml5	375	12	shown	show	VBN
cord-343791-0vykwml5	375	13	encouraging	encourage	VBG
cord-343791-0vykwml5	375	14	preclinical	preclinical	JJ
cord-343791-0vykwml5	375	15	data	datum	NNS
cord-343791-0vykwml5	375	16	and	and	CC
cord-343791-0vykwml5	375	17	are	be	VBP
cord-343791-0vykwml5	375	18	being	be	VBG
cord-343791-0vykwml5	375	19	investigated	investigate	VBN
cord-343791-0vykwml5	375	20	in	in	IN
cord-343791-0vykwml5	375	21	new	new	JJ
cord-343791-0vykwml5	375	22	disease	disease	NN
cord-343791-0vykwml5	375	23	models	model	NNS
cord-343791-0vykwml5	375	24	.	.	.
cord-343791-0vykwml5	376	1	On	on	IN
cord-343791-0vykwml5	376	2	the	the	DT
cord-343791-0vykwml5	376	3	other	other	JJ
cord-343791-0vykwml5	376	4	,	,	,
cord-343791-0vykwml5	376	5	the	the	DT
cord-343791-0vykwml5	376	6	discovery	discovery	NN
cord-343791-0vykwml5	376	7	of	of	IN
cord-343791-0vykwml5	376	8	a	a	DT
cord-343791-0vykwml5	376	9	new	new	JJ
cord-343791-0vykwml5	376	10	,	,	,
cord-343791-0vykwml5	376	11	more	more	RBR
cord-343791-0vykwml5	376	12	efficacious	efficacious	JJ
cord-343791-0vykwml5	376	13	and	and	CC
cord-343791-0vykwml5	376	14	versatile	versatile	JJ
cord-343791-0vykwml5	376	15	platforms	platform	NNS
cord-343791-0vykwml5	376	16	could	could	MD
cord-343791-0vykwml5	376	17	spur	spur	VB
cord-343791-0vykwml5	376	18	unforeseen	unforeseen	JJ
cord-343791-0vykwml5	376	19	therapies	therapy	NNS
cord-343791-0vykwml5	376	20	based	base	VBN
cord-343791-0vykwml5	376	21	on	on	IN
cord-343791-0vykwml5	376	22	the	the	DT
cord-343791-0vykwml5	376	23	self	self	NN
cord-343791-0vykwml5	376	24	-	-	HYPH
cord-343791-0vykwml5	376	25	assembling	assemble	VBG
cord-343791-0vykwml5	376	26	concept	concept	NN
cord-343791-0vykwml5	376	27	.	.	.
cord-343791-0vykwml5	377	1	Either	either	DT
cord-343791-0vykwml5	377	2	way	way	NN
cord-343791-0vykwml5	377	3	,	,	,
cord-343791-0vykwml5	377	4	we	-PRON-	PRP
cord-343791-0vykwml5	377	5	predict	predict	VBP
cord-343791-0vykwml5	377	6	that	that	IN
cord-343791-0vykwml5	377	7	self	self	NN
cord-343791-0vykwml5	377	8	-	-	HYPH
cord-343791-0vykwml5	377	9	assembling	assemble	VBG
cord-343791-0vykwml5	377	10	peptide	peptide	NN
cord-343791-0vykwml5	377	11	and	and	CC
cord-343791-0vykwml5	377	12	protein	protein	NN
cord-343791-0vykwml5	377	13	technologies	technology	NNS
cord-343791-0vykwml5	377	14	will	will	MD
cord-343791-0vykwml5	377	15	continue	continue	VB
cord-343791-0vykwml5	377	16	making	make	VBG
cord-343791-0vykwml5	377	17	strides	stride	NNS
cord-343791-0vykwml5	377	18	in	in	IN
cord-343791-0vykwml5	377	19	the	the	DT
cord-343791-0vykwml5	377	20	preclinical	preclinical	JJ
cord-343791-0vykwml5	377	21	and	and	CC
cord-343791-0vykwml5	377	22	clinical	clinical	JJ
cord-343791-0vykwml5	377	23	realms	realm	NNS
cord-343791-0vykwml5	377	24	.	.	.
cord-343791-0vykwml5	378	1	Proc	proc	VB
cord-343791-0vykwml5	378	2	.	.	.
cord-343791-0vykwml5	379	1	Natl	Natl	NNP
cord-343791-0vykwml5	379	2	.	.	.
cord-343791-0vykwml5	379	3	Acad	Acad	NNP
cord-343791-0vykwml5	379	4	.	.	.
cord-343791-0vykwml5	380	1	Sci	Sci	NNP
cord-343791-0vykwml5	380	2	Proc	Proc	NNP
cord-343791-0vykwml5	380	3	.	.	.
cord-343791-0vykwml5	381	1	Natl	Natl	NNP
cord-343791-0vykwml5	381	2	.	.	.
cord-343791-0vykwml5	381	3	Acad	Acad	NNP
cord-343791-0vykwml5	381	4	.	.	.
cord-343791-0vykwml5	382	1	Sci	Sci	NNP
cord-343791-0vykwml5	382	2	Proc	Proc	NNP
cord-343791-0vykwml5	382	3	.	.	.
cord-343791-0vykwml5	383	1	Natl	Natl	NNP
cord-343791-0vykwml5	383	2	.	.	.
cord-343791-0vykwml5	383	3	Acad	Acad	NNP
cord-343791-0vykwml5	383	4	.	.	.
cord-343791-0vykwml5	384	1	Sci	Sci	NNP
cord-343791-0vykwml5	384	2	Proc	Proc	NNP
cord-343791-0vykwml5	384	3	.	.	.
cord-343791-0vykwml5	385	1	Natl	Natl	NNP
cord-343791-0vykwml5	385	2	.	.	.
cord-343791-0vykwml5	385	3	Acad	Acad	NNP
cord-343791-0vykwml5	385	4	.	.	.
cord-343791-0vykwml5	386	1	Sci	Sci	NNP
cord-343791-0vykwml5	386	2	Proc	Proc	NNP
cord-343791-0vykwml5	386	3	.	.	.
cord-343791-0vykwml5	387	1	Natl	Natl	NNP
cord-343791-0vykwml5	387	2	.	.	.
cord-343791-0vykwml5	387	3	Acad	Acad	NNP
cord-343791-0vykwml5	387	4	.	.	.
cord-343791-0vykwml5	388	1	Sci	Sci	NNP
cord-343791-0vykwml5	388	2	Proc	Proc	NNP
cord-343791-0vykwml5	388	3	.	.	.
cord-343791-0vykwml5	389	1	Natl	Natl	NNP
cord-343791-0vykwml5	389	2	.	.	.
cord-343791-0vykwml5	389	3	Acad	Acad	NNP
cord-343791-0vykwml5	389	4	.	.	.
cord-343791-0vykwml5	390	1	Sci	Sci	NNP
cord-343791-0vykwml5	390	2	Proc	Proc	NNP
cord-343791-0vykwml5	390	3	.	.	.
cord-343791-0vykwml5	391	1	Natl	Natl	NNP
cord-343791-0vykwml5	391	2	.	.	.
cord-343791-0vykwml5	391	3	Acad	Acad	NNP
cord-343791-0vykwml5	391	4	.	.	.
cord-343791-0vykwml5	392	1	Sci	Sci	NNP
cord-343791-0vykwml5	392	2	Proc	Proc	NNP
cord-343791-0vykwml5	392	3	.	.	.
cord-343791-0vykwml5	393	1	Natl	Natl	NNP
cord-343791-0vykwml5	393	2	.	.	.
cord-343791-0vykwml5	393	3	Acad	Acad	NNP
cord-343791-0vykwml5	393	4	.	.	.
cord-343791-0vykwml5	394	1	Sci	Sci	NNP
cord-343791-0vykwml5	394	2	Proc	Proc	NNP
cord-343791-0vykwml5	394	3	.	.	.
cord-343791-0vykwml5	395	1	Natl	Natl	NNP
cord-343791-0vykwml5	395	2	.	.	.
cord-343791-0vykwml5	395	3	Acad	Acad	NNP
cord-343791-0vykwml5	395	4	.	.	.
cord-343791-0vykwml5	396	1	Sci	Sci	NNP
cord-343791-0vykwml5	396	2	Proc	Proc	NNP
cord-343791-0vykwml5	396	3	.	.	.
cord-343791-0vykwml5	397	1	Natl	Natl	NNP
cord-343791-0vykwml5	397	2	.	.	.
cord-343791-0vykwml5	397	3	Acad	Acad	NNP
cord-343791-0vykwml5	397	4	.	.	.
cord-343791-0vykwml5	398	1	Sci	Sci	NNP
cord-343791-0vykwml5	398	2	Proc	Proc	NNP
cord-343791-0vykwml5	398	3	.	.	.
cord-343791-0vykwml5	399	1	Natl	Natl	NNP
cord-343791-0vykwml5	399	2	.	.	.
cord-343791-0vykwml5	399	3	Acad	Acad	NNP
cord-343791-0vykwml5	399	4	.	.	.
cord-343791-0vykwml5	400	1	Sci	Sci	NNP
cord-343791-0vykwml5	400	2	Biomate	Biomate	NNP
cord-343791-0vykwml5	400	3	rials	rial	NNS
cord-343791-0vykwml5	400	4	2013	2013	CD
cord-343791-0vykwml5	400	5	K.M.H.	K.M.H.	NNP
cord-343791-0vykwml5	400	6	and	and	CC
cord-343791-0vykwml5	400	7	C.N.F.	C.N.F.	NNP
cord-343791-0vykwml5	400	8	contributed	contribute	VBD
cord-343791-0vykwml5	400	9	equally	equally	RB
cord-343791-0vykwml5	400	10	to	to	IN
cord-343791-0vykwml5	400	11	this	this	DT
cord-343791-0vykwml5	400	12	work	work	NN
cord-343791-0vykwml5	400	13	.	.	.
cord-343791-0vykwml5	401	1	Research	research	NN
cord-343791-0vykwml5	401	2	on	on	IN
cord-343791-0vykwml5	401	3	supramolecular	supramolecular	JJ
cord-343791-0vykwml5	401	4	peptide	peptide	NN
cord-343791-0vykwml5	401	5	biomaterials	biomaterial	NNS
cord-343791-0vykwml5	401	6	in	in	IN
cord-343791-0vykwml5	401	7	our	-PRON-	PRP$
cord-343791-0vykwml5	401	8	group	group	NN
cord-343791-0vykwml5	401	9	has	have	VBZ
cord-343791-0vykwml5	401	10	been	be	VBN
cord-343791-0vykwml5	401	11	supported	support	VBN
cord-343791-0vykwml5	401	12	by	by	IN
cord-343791-0vykwml5	401	13	the	the	DT
cord-343791-0vykwml5	401	14	National	National	NNP
cord-343791-0vykwml5	401	15	Institutes	Institutes	NNPS
cord-343791-0vykwml5	401	16	of	of	IN
cord-343791-0vykwml5	401	17	Health	Health	NNP
cord-343791-0vykwml5	401	18	under	under	IN
cord-343791-0vykwml5	401	19	grant	grant	NN
cord-343791-0vykwml5	401	20	numbers	number	NNS
cord-343791-0vykwml5	401	21	5R01EB009701	5R01EB009701	NNP
cord-343791-0vykwml5	401	22	;	;	:
cord-343791-0vykwml5	401	23	5R01AI118182	5r01ai118182	CD
cord-343791-0vykwml5	401	24	;	;	:
cord-343791-0vykwml5	401	25	5R21CA196434	5r21ca196434	CD
cord-343791-0vykwml5	401	26	;	;	:
cord-343791-0vykwml5	401	27	and	and	CC
cord-343791-0vykwml5	401	28	7R21AR066244	7r21ar066244	CD
cord-343791-0vykwml5	401	29	)	)	-RRB-
cord-343791-0vykwml5	401	30	.	.	.
cord-343791-0vykwml5	402	1	This	this	DT
cord-343791-0vykwml5	402	2	Progress	Progress	NNP
cord-343791-0vykwml5	402	3	Report	Report	NNP
cord-343791-0vykwml5	402	4	's	's	POS
cord-343791-0vykwml5	402	5	contents	content	NNS
cord-343791-0vykwml5	402	6	are	be	VBP
cord-343791-0vykwml5	402	7	solely	solely	RB
cord-343791-0vykwml5	402	8	the	the	DT
cord-343791-0vykwml5	402	9	responsibility	responsibility	NN
cord-343791-0vykwml5	402	10	of	of	IN
cord-343791-0vykwml5	402	11	the	the	DT
cord-343791-0vykwml5	402	12	authors	author	NNS
cord-343791-0vykwml5	402	13	and	and	CC
cord-343791-0vykwml5	402	14	do	do	VBP
cord-343791-0vykwml5	402	15	not	not	RB
cord-343791-0vykwml5	402	16	necessarily	necessarily	RB
cord-343791-0vykwml5	402	17	represent	represent	VB
cord-343791-0vykwml5	402	18	the	the	DT
cord-343791-0vykwml5	402	19	official	official	JJ
cord-343791-0vykwml5	402	20	views	view	NNS
cord-343791-0vykwml5	402	21	of	of	IN
cord-343791-0vykwml5	402	22	these	these	DT
cord-343791-0vykwml5	402	23	agencies	agency	NNS
cord-343791-0vykwml5	402	24	.	.	.