id sid tid token lemma pos cord-287123-ldkuwcc7 1 1 key key NN cord-287123-ldkuwcc7 1 2 : : : cord-287123-ldkuwcc7 1 3 cord-287123-ldkuwcc7 cord-287123-ldkuwcc7 NN cord-287123-ldkuwcc7 1 4 authors author NNS cord-287123-ldkuwcc7 1 5 : : : cord-287123-ldkuwcc7 2 1 He -PRON- PRP cord-287123-ldkuwcc7 2 2 , , , cord-287123-ldkuwcc7 2 3 Hui Hui NNP cord-287123-ldkuwcc7 2 4 - - HYPH cord-287123-ldkuwcc7 2 5 Qiong Qiong NNP cord-287123-ldkuwcc7 2 6 ; ; : cord-287123-ldkuwcc7 2 7 Ye Ye NNP cord-287123-ldkuwcc7 2 8 , , , cord-287123-ldkuwcc7 2 9 Richard Richard NNP cord-287123-ldkuwcc7 2 10 D. D. NNP cord-287123-ldkuwcc7 2 11 title title NN cord-287123-ldkuwcc7 2 12 : : : cord-287123-ldkuwcc7 3 1 The the DT cord-287123-ldkuwcc7 3 2 Formyl Formyl NNP cord-287123-ldkuwcc7 3 3 Peptide Peptide NNP cord-287123-ldkuwcc7 3 4 Receptors Receptors NNPS cord-287123-ldkuwcc7 3 5 : : : cord-287123-ldkuwcc7 3 6 Diversity diversity NN cord-287123-ldkuwcc7 3 7 of of IN cord-287123-ldkuwcc7 3 8 Ligands Ligands NNPS cord-287123-ldkuwcc7 3 9 and and CC cord-287123-ldkuwcc7 3 10 Mechanism Mechanism NNP cord-287123-ldkuwcc7 3 11 for for IN cord-287123-ldkuwcc7 3 12 Recognition Recognition NNP cord-287123-ldkuwcc7 3 13 date date NN cord-287123-ldkuwcc7 3 14 : : : cord-287123-ldkuwcc7 3 15 2017 2017 CD cord-287123-ldkuwcc7 3 16 - - HYPH cord-287123-ldkuwcc7 3 17 03 03 CD cord-287123-ldkuwcc7 3 18 - - SYM cord-287123-ldkuwcc7 3 19 13 13 CD cord-287123-ldkuwcc7 3 20 journal journal NN cord-287123-ldkuwcc7 3 21 : : : cord-287123-ldkuwcc7 4 1 Molecules molecule NNS cord-287123-ldkuwcc7 4 2 DOI DOI NNP cord-287123-ldkuwcc7 4 3 : : : cord-287123-ldkuwcc7 5 1 10.3390 10.3390 CD cord-287123-ldkuwcc7 5 2 / / SYM cord-287123-ldkuwcc7 5 3 molecules22030455 molecules22030455 CD cord-287123-ldkuwcc7 5 4 sha sha NNP cord-287123-ldkuwcc7 5 5 : : : cord-287123-ldkuwcc7 6 1 6c7ee2062b49226bfee08114f12cb1cd07509d9d 6c7ee2062b49226bfee08114f12cb1cd07509d9d NNP cord-287123-ldkuwcc7 6 2 doc_id doc_id NNP cord-287123-ldkuwcc7 6 3 : : : cord-287123-ldkuwcc7 7 1 287123 287123 CD cord-287123-ldkuwcc7 7 2 cord_uid cord_uid NN cord-287123-ldkuwcc7 7 3 : : : cord-287123-ldkuwcc7 8 1 ldkuwcc7 ldkuwcc7 NNP cord-287123-ldkuwcc7 8 2 The the DT cord-287123-ldkuwcc7 8 3 formyl formyl NNP cord-287123-ldkuwcc7 8 4 peptide peptide NN cord-287123-ldkuwcc7 8 5 receptors receptor NNS cord-287123-ldkuwcc7 8 6 ( ( -LRB- cord-287123-ldkuwcc7 8 7 FPRs FPRs NNP cord-287123-ldkuwcc7 8 8 ) ) -RRB- cord-287123-ldkuwcc7 8 9 are be VBP cord-287123-ldkuwcc7 8 10 G g NN cord-287123-ldkuwcc7 8 11 protein protein NN cord-287123-ldkuwcc7 8 12 - - HYPH cord-287123-ldkuwcc7 8 13 coupled couple VBN cord-287123-ldkuwcc7 8 14 receptors receptor NNS cord-287123-ldkuwcc7 8 15 that that WDT cord-287123-ldkuwcc7 8 16 transduce transduce VBP cord-287123-ldkuwcc7 8 17 chemotactic chemotactic JJ cord-287123-ldkuwcc7 8 18 signals signal NNS cord-287123-ldkuwcc7 8 19 in in IN cord-287123-ldkuwcc7 8 20 phagocytes phagocyte NNS cord-287123-ldkuwcc7 8 21 and and CC cord-287123-ldkuwcc7 8 22 mediate mediate VB cord-287123-ldkuwcc7 8 23 host host NN cord-287123-ldkuwcc7 8 24 - - HYPH cord-287123-ldkuwcc7 8 25 defense defense NN cord-287123-ldkuwcc7 8 26 as as RB cord-287123-ldkuwcc7 8 27 well well RB cord-287123-ldkuwcc7 8 28 as as IN cord-287123-ldkuwcc7 8 29 inflammatory inflammatory JJ cord-287123-ldkuwcc7 8 30 responses response NNS cord-287123-ldkuwcc7 8 31 including include VBG cord-287123-ldkuwcc7 8 32 cell cell NN cord-287123-ldkuwcc7 8 33 adhesion adhesion NN cord-287123-ldkuwcc7 8 34 , , , cord-287123-ldkuwcc7 8 35 directed direct VBN cord-287123-ldkuwcc7 8 36 migration migration NN cord-287123-ldkuwcc7 8 37 , , , cord-287123-ldkuwcc7 8 38 granule granule NN cord-287123-ldkuwcc7 8 39 release release NN cord-287123-ldkuwcc7 8 40 and and CC cord-287123-ldkuwcc7 8 41 superoxide superoxide NN cord-287123-ldkuwcc7 8 42 production production NN cord-287123-ldkuwcc7 8 43 . . . cord-287123-ldkuwcc7 9 1 In in IN cord-287123-ldkuwcc7 9 2 recent recent JJ cord-287123-ldkuwcc7 9 3 years year NNS cord-287123-ldkuwcc7 9 4 , , , cord-287123-ldkuwcc7 9 5 the the DT cord-287123-ldkuwcc7 9 6 cellular cellular JJ cord-287123-ldkuwcc7 9 7 distribution distribution NN cord-287123-ldkuwcc7 9 8 and and CC cord-287123-ldkuwcc7 9 9 biological biological JJ cord-287123-ldkuwcc7 9 10 functions function NNS cord-287123-ldkuwcc7 9 11 of of IN cord-287123-ldkuwcc7 9 12 FPRs fpr NNS cord-287123-ldkuwcc7 9 13 have have VBP cord-287123-ldkuwcc7 9 14 expanded expand VBN cord-287123-ldkuwcc7 9 15 to to TO cord-287123-ldkuwcc7 9 16 include include VB cord-287123-ldkuwcc7 9 17 additional additional JJ cord-287123-ldkuwcc7 9 18 roles role NNS cord-287123-ldkuwcc7 9 19 in in IN cord-287123-ldkuwcc7 9 20 homeostasis homeostasis NN cord-287123-ldkuwcc7 9 21 of of IN cord-287123-ldkuwcc7 9 22 organ organ NN cord-287123-ldkuwcc7 9 23 functions function NNS cord-287123-ldkuwcc7 9 24 and and CC cord-287123-ldkuwcc7 9 25 modulation modulation NN cord-287123-ldkuwcc7 9 26 of of IN cord-287123-ldkuwcc7 9 27 inflammation inflammation NN cord-287123-ldkuwcc7 9 28 . . . cord-287123-ldkuwcc7 10 1 In in IN cord-287123-ldkuwcc7 10 2 a a DT cord-287123-ldkuwcc7 10 3 prototype prototype NN cord-287123-ldkuwcc7 10 4 , , , cord-287123-ldkuwcc7 10 5 FPRs fpr NNS cord-287123-ldkuwcc7 10 6 recognize recognize VBP cord-287123-ldkuwcc7 10 7 peptides peptide NNS cord-287123-ldkuwcc7 10 8 containing contain VBG cord-287123-ldkuwcc7 10 9 N n CD cord-287123-ldkuwcc7 10 10 - - HYPH cord-287123-ldkuwcc7 10 11 formylated formylate VBN cord-287123-ldkuwcc7 10 12 methionine methionine NN cord-287123-ldkuwcc7 10 13 such such JJ cord-287123-ldkuwcc7 10 14 as as IN cord-287123-ldkuwcc7 10 15 those those DT cord-287123-ldkuwcc7 10 16 produced produce VBN cord-287123-ldkuwcc7 10 17 in in IN cord-287123-ldkuwcc7 10 18 bacteria bacteria NNS cord-287123-ldkuwcc7 10 19 and and CC cord-287123-ldkuwcc7 10 20 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 10 21 , , , cord-287123-ldkuwcc7 10 22 thereby thereby RB cord-287123-ldkuwcc7 10 23 serving serve VBG cord-287123-ldkuwcc7 10 24 as as IN cord-287123-ldkuwcc7 10 25 pattern pattern NN cord-287123-ldkuwcc7 10 26 recognition recognition NN cord-287123-ldkuwcc7 10 27 receptors receptor NNS cord-287123-ldkuwcc7 10 28 . . . cord-287123-ldkuwcc7 11 1 The the DT cord-287123-ldkuwcc7 11 2 repertoire repertoire NN cord-287123-ldkuwcc7 11 3 of of IN cord-287123-ldkuwcc7 11 4 FPR fpr NN cord-287123-ldkuwcc7 11 5 ligands ligand NNS cord-287123-ldkuwcc7 11 6 , , , cord-287123-ldkuwcc7 11 7 however however RB cord-287123-ldkuwcc7 11 8 , , , cord-287123-ldkuwcc7 11 9 has have VBZ cord-287123-ldkuwcc7 11 10 expanded expand VBN cord-287123-ldkuwcc7 11 11 rapidly rapidly RB cord-287123-ldkuwcc7 11 12 to to TO cord-287123-ldkuwcc7 11 13 include include VB cord-287123-ldkuwcc7 11 14 not not RB cord-287123-ldkuwcc7 11 15 only only RB cord-287123-ldkuwcc7 11 16 N N NNP cord-287123-ldkuwcc7 11 17 - - HYPH cord-287123-ldkuwcc7 11 18 formyl formyl NNP cord-287123-ldkuwcc7 11 19 peptides peptide NNS cord-287123-ldkuwcc7 11 20 from from IN cord-287123-ldkuwcc7 11 21 microbes microbe NNS cord-287123-ldkuwcc7 11 22 but but CC cord-287123-ldkuwcc7 11 23 also also RB cord-287123-ldkuwcc7 11 24 non non JJ cord-287123-ldkuwcc7 11 25 - - JJ cord-287123-ldkuwcc7 11 26 formyl formyl JJ cord-287123-ldkuwcc7 11 27 peptides peptide NNS cord-287123-ldkuwcc7 11 28 of of IN cord-287123-ldkuwcc7 11 29 microbial microbial JJ cord-287123-ldkuwcc7 11 30 and and CC cord-287123-ldkuwcc7 11 31 host host NN cord-287123-ldkuwcc7 11 32 origins origin NNS cord-287123-ldkuwcc7 11 33 , , , cord-287123-ldkuwcc7 11 34 synthetic synthetic JJ cord-287123-ldkuwcc7 11 35 small small JJ cord-287123-ldkuwcc7 11 36 molecules molecule NNS cord-287123-ldkuwcc7 11 37 and and CC cord-287123-ldkuwcc7 11 38 an an DT cord-287123-ldkuwcc7 11 39 eicosanoid eicosanoid NN cord-287123-ldkuwcc7 11 40 . . . cord-287123-ldkuwcc7 12 1 How how WRB cord-287123-ldkuwcc7 12 2 these these DT cord-287123-ldkuwcc7 12 3 chemically chemically RB cord-287123-ldkuwcc7 12 4 diverse diverse JJ cord-287123-ldkuwcc7 12 5 ligands ligand NNS cord-287123-ldkuwcc7 12 6 are be VBP cord-287123-ldkuwcc7 12 7 recognized recognize VBN cord-287123-ldkuwcc7 12 8 by by IN cord-287123-ldkuwcc7 12 9 the the DT cord-287123-ldkuwcc7 12 10 three three CD cord-287123-ldkuwcc7 12 11 human human JJ cord-287123-ldkuwcc7 12 12 FPRs fpr NNS cord-287123-ldkuwcc7 12 13 ( ( -LRB- cord-287123-ldkuwcc7 12 14 FPR1 FPR1 NNP cord-287123-ldkuwcc7 12 15 , , , cord-287123-ldkuwcc7 12 16 FPR2 FPR2 NNP cord-287123-ldkuwcc7 12 17 and and CC cord-287123-ldkuwcc7 12 18 FPR3 FPR3 NNP cord-287123-ldkuwcc7 12 19 ) ) -RRB- cord-287123-ldkuwcc7 12 20 and and CC cord-287123-ldkuwcc7 12 21 their -PRON- PRP$ cord-287123-ldkuwcc7 12 22 murine murine JJ cord-287123-ldkuwcc7 12 23 equivalents equivalent NNS cord-287123-ldkuwcc7 12 24 is be VBZ cord-287123-ldkuwcc7 12 25 largely largely RB cord-287123-ldkuwcc7 12 26 unclear unclear JJ cord-287123-ldkuwcc7 12 27 . . . cord-287123-ldkuwcc7 13 1 In in IN cord-287123-ldkuwcc7 13 2 the the DT cord-287123-ldkuwcc7 13 3 absence absence NN cord-287123-ldkuwcc7 13 4 of of IN cord-287123-ldkuwcc7 13 5 crystal crystal NN cord-287123-ldkuwcc7 13 6 structures structure NNS cord-287123-ldkuwcc7 13 7 for for IN cord-287123-ldkuwcc7 13 8 the the DT cord-287123-ldkuwcc7 13 9 FPRs fpr NNS cord-287123-ldkuwcc7 13 10 , , , cord-287123-ldkuwcc7 13 11 site site NN cord-287123-ldkuwcc7 13 12 - - HYPH cord-287123-ldkuwcc7 13 13 directed direct VBN cord-287123-ldkuwcc7 13 14 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 13 15 , , , cord-287123-ldkuwcc7 13 16 computer computer NN cord-287123-ldkuwcc7 13 17 - - HYPH cord-287123-ldkuwcc7 13 18 aided aid VBN cord-287123-ldkuwcc7 13 19 ligand ligand NN cord-287123-ldkuwcc7 13 20 docking docking NN cord-287123-ldkuwcc7 13 21 and and CC cord-287123-ldkuwcc7 13 22 structural structural JJ cord-287123-ldkuwcc7 13 23 simulation simulation NN cord-287123-ldkuwcc7 13 24 have have VBP cord-287123-ldkuwcc7 13 25 led lead VBN cord-287123-ldkuwcc7 13 26 to to IN cord-287123-ldkuwcc7 13 27 the the DT cord-287123-ldkuwcc7 13 28 identification identification NN cord-287123-ldkuwcc7 13 29 of of IN cord-287123-ldkuwcc7 13 30 amino amino JJ cord-287123-ldkuwcc7 13 31 acids acid NNS cord-287123-ldkuwcc7 13 32 within within IN cord-287123-ldkuwcc7 13 33 FPR1 FPR1 NNP cord-287123-ldkuwcc7 13 34 and and CC cord-287123-ldkuwcc7 13 35 FPR2 FPR2 NNP cord-287123-ldkuwcc7 13 36 that that WDT cord-287123-ldkuwcc7 13 37 interact interact VBP cord-287123-ldkuwcc7 13 38 with with IN cord-287123-ldkuwcc7 13 39 several several JJ cord-287123-ldkuwcc7 13 40 formyl formyl NNP cord-287123-ldkuwcc7 13 41 peptides peptide NNS cord-287123-ldkuwcc7 13 42 . . . cord-287123-ldkuwcc7 14 1 This this DT cord-287123-ldkuwcc7 14 2 review review NN cord-287123-ldkuwcc7 14 3 article article NN cord-287123-ldkuwcc7 14 4 summarizes summarize VBZ cord-287123-ldkuwcc7 14 5 the the DT cord-287123-ldkuwcc7 14 6 progress progress NN cord-287123-ldkuwcc7 14 7 made make VBN cord-287123-ldkuwcc7 14 8 in in IN cord-287123-ldkuwcc7 14 9 the the DT cord-287123-ldkuwcc7 14 10 understanding understanding NN cord-287123-ldkuwcc7 14 11 of of IN cord-287123-ldkuwcc7 14 12 FPR fpr NN cord-287123-ldkuwcc7 14 13 ligand ligand NN cord-287123-ldkuwcc7 14 14 diversity diversity NN cord-287123-ldkuwcc7 14 15 as as RB cord-287123-ldkuwcc7 14 16 well well RB cord-287123-ldkuwcc7 14 17 as as IN cord-287123-ldkuwcc7 14 18 ligand ligand NN cord-287123-ldkuwcc7 14 19 recognition recognition NN cord-287123-ldkuwcc7 14 20 mechanisms mechanism NNS cord-287123-ldkuwcc7 14 21 used use VBN cord-287123-ldkuwcc7 14 22 by by IN cord-287123-ldkuwcc7 14 23 these these DT cord-287123-ldkuwcc7 14 24 receptors receptor NNS cord-287123-ldkuwcc7 14 25 . . . cord-287123-ldkuwcc7 15 1 The the DT cord-287123-ldkuwcc7 15 2 formyl formyl NNP cord-287123-ldkuwcc7 15 3 peptide peptide NN cord-287123-ldkuwcc7 15 4 receptors receptor NNS cord-287123-ldkuwcc7 15 5 ( ( -LRB- cord-287123-ldkuwcc7 15 6 FPRs FPRs NNP cord-287123-ldkuwcc7 15 7 ) ) -RRB- cord-287123-ldkuwcc7 15 8 are be VBP cord-287123-ldkuwcc7 15 9 a a DT cord-287123-ldkuwcc7 15 10 group group NN cord-287123-ldkuwcc7 15 11 of of IN cord-287123-ldkuwcc7 15 12 G g NN cord-287123-ldkuwcc7 15 13 protein protein NN cord-287123-ldkuwcc7 15 14 - - HYPH cord-287123-ldkuwcc7 15 15 coupled couple VBN cord-287123-ldkuwcc7 15 16 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 15 17 receptors receptor NNS cord-287123-ldkuwcc7 15 18 that that WDT cord-287123-ldkuwcc7 15 19 play play VBP cord-287123-ldkuwcc7 15 20 important important JJ cord-287123-ldkuwcc7 15 21 roles role NNS cord-287123-ldkuwcc7 15 22 in in IN cord-287123-ldkuwcc7 15 23 host host NN cord-287123-ldkuwcc7 15 24 defense defense NN cord-287123-ldkuwcc7 15 25 and and CC cord-287123-ldkuwcc7 15 26 inflammation inflammation NN cord-287123-ldkuwcc7 15 27 [ [ -LRB- cord-287123-ldkuwcc7 15 28 1 1 CD cord-287123-ldkuwcc7 15 29 , , , cord-287123-ldkuwcc7 15 30 2 2 CD cord-287123-ldkuwcc7 15 31 ] ] -RRB- cord-287123-ldkuwcc7 15 32 . . . cord-287123-ldkuwcc7 16 1 They -PRON- PRP cord-287123-ldkuwcc7 16 2 are be VBP cord-287123-ldkuwcc7 16 3 so so RB cord-287123-ldkuwcc7 16 4 named name VBN cord-287123-ldkuwcc7 16 5 because because IN cord-287123-ldkuwcc7 16 6 their -PRON- PRP$ cord-287123-ldkuwcc7 16 7 cognate cognate JJ cord-287123-ldkuwcc7 16 8 agonists agonist NNS cord-287123-ldkuwcc7 16 9 are be VBP cord-287123-ldkuwcc7 16 10 peptides peptide NNS cord-287123-ldkuwcc7 16 11 bearing bear VBG cord-287123-ldkuwcc7 16 12 formylated formylate VBN cord-287123-ldkuwcc7 16 13 methionine methionine NN cord-287123-ldkuwcc7 16 14 ( ( -LRB- cord-287123-ldkuwcc7 16 15 fMet fMet NNP cord-287123-ldkuwcc7 16 16 ) ) -RRB- cord-287123-ldkuwcc7 16 17 , , , cord-287123-ldkuwcc7 16 18 such such JJ cord-287123-ldkuwcc7 16 19 as as IN cord-287123-ldkuwcc7 16 20 those those DT cord-287123-ldkuwcc7 16 21 derived derive VBN cord-287123-ldkuwcc7 16 22 from from IN cord-287123-ldkuwcc7 16 23 bacterial bacterial JJ cord-287123-ldkuwcc7 16 24 and and CC cord-287123-ldkuwcc7 16 25 mitochondrial mitochondrial JJ cord-287123-ldkuwcc7 16 26 proteins protein NNS cord-287123-ldkuwcc7 16 27 [ [ -LRB- cord-287123-ldkuwcc7 16 28 3 3 CD cord-287123-ldkuwcc7 16 29 , , , cord-287123-ldkuwcc7 16 30 4 4 CD cord-287123-ldkuwcc7 16 31 ] ] -RRB- cord-287123-ldkuwcc7 16 32 . . . cord-287123-ldkuwcc7 17 1 The the DT cord-287123-ldkuwcc7 17 2 present present JJ cord-287123-ldkuwcc7 17 3 review review NN cord-287123-ldkuwcc7 17 4 focuses focus VBZ cord-287123-ldkuwcc7 17 5 on on IN cord-287123-ldkuwcc7 17 6 the the DT cord-287123-ldkuwcc7 17 7 FPR FPR NNP cord-287123-ldkuwcc7 17 8 family family NN cord-287123-ldkuwcc7 17 9 members member NNS cord-287123-ldkuwcc7 17 10 in in IN cord-287123-ldkuwcc7 17 11 humans human NNS cord-287123-ldkuwcc7 17 12 and and CC cord-287123-ldkuwcc7 17 13 mice mouse NNS cord-287123-ldkuwcc7 17 14 and and CC cord-287123-ldkuwcc7 17 15 their -PRON- PRP$ cord-287123-ldkuwcc7 17 16 interaction interaction NN cord-287123-ldkuwcc7 17 17 with with IN cord-287123-ldkuwcc7 17 18 a a DT cord-287123-ldkuwcc7 17 19 wide wide JJ cord-287123-ldkuwcc7 17 20 variety variety NN cord-287123-ldkuwcc7 17 21 of of IN cord-287123-ldkuwcc7 17 22 ligands ligand NNS cord-287123-ldkuwcc7 17 23 . . . cord-287123-ldkuwcc7 18 1 The the DT cord-287123-ldkuwcc7 18 2 reader reader NN cord-287123-ldkuwcc7 18 3 is be VBZ cord-287123-ldkuwcc7 18 4 referred refer VBN cord-287123-ldkuwcc7 18 5 to to IN cord-287123-ldkuwcc7 18 6 recently recently RB cord-287123-ldkuwcc7 18 7 published publish VBN cord-287123-ldkuwcc7 18 8 reviews review NNS cord-287123-ldkuwcc7 18 9 on on IN cord-287123-ldkuwcc7 18 10 FPR fpr NN cord-287123-ldkuwcc7 18 11 signaling signal VBG cord-287123-ldkuwcc7 18 12 [ [ -LRB- cord-287123-ldkuwcc7 18 13 5 5 CD cord-287123-ldkuwcc7 18 14 ] ] -RRB- cord-287123-ldkuwcc7 18 15 , , , cord-287123-ldkuwcc7 18 16 synthetic synthetic JJ cord-287123-ldkuwcc7 18 17 non non JJ cord-287123-ldkuwcc7 18 18 - - JJ cord-287123-ldkuwcc7 18 19 peptide peptide JJ cord-287123-ldkuwcc7 18 20 ligands ligand NNS cord-287123-ldkuwcc7 18 21 for for IN cord-287123-ldkuwcc7 18 22 FPRs fpr NNS cord-287123-ldkuwcc7 18 23 [ [ -LRB- cord-287123-ldkuwcc7 18 24 6 6 CD cord-287123-ldkuwcc7 18 25 ] ] -RRB- cord-287123-ldkuwcc7 18 26 and and CC cord-287123-ldkuwcc7 18 27 characterization characterization NN cord-287123-ldkuwcc7 18 28 of of IN cord-287123-ldkuwcc7 18 29 FPR fpr NN cord-287123-ldkuwcc7 18 30 knockout knockout NN cord-287123-ldkuwcc7 18 31 mice mouse NNS cord-287123-ldkuwcc7 18 32 [ [ -LRB- cord-287123-ldkuwcc7 18 33 7 7 CD cord-287123-ldkuwcc7 18 34 ] ] -RRB- cord-287123-ldkuwcc7 18 35 . . . cord-287123-ldkuwcc7 19 1 The the DT cord-287123-ldkuwcc7 19 2 reader reader NN cord-287123-ldkuwcc7 19 3 is be VBZ cord-287123-ldkuwcc7 19 4 also also RB cord-287123-ldkuwcc7 19 5 referred refer VBN cord-287123-ldkuwcc7 19 6 to to IN cord-287123-ldkuwcc7 19 7 a a DT cord-287123-ldkuwcc7 19 8 general general JJ cord-287123-ldkuwcc7 19 9 overview overview NN cord-287123-ldkuwcc7 19 10 of of IN cord-287123-ldkuwcc7 19 11 FPRs fpr NNS cord-287123-ldkuwcc7 19 12 and and CC cord-287123-ldkuwcc7 19 13 their -PRON- PRP$ cord-287123-ldkuwcc7 19 14 nomenclature nomenclature NN cord-287123-ldkuwcc7 19 15 [ [ -LRB- cord-287123-ldkuwcc7 19 16 2 2 CD cord-287123-ldkuwcc7 19 17 ] ] -RRB- cord-287123-ldkuwcc7 19 18 . . . cord-287123-ldkuwcc7 20 1 Three three CD cord-287123-ldkuwcc7 20 2 genes gene NNS cord-287123-ldkuwcc7 20 3 coding code VBG cord-287123-ldkuwcc7 20 4 for for IN cord-287123-ldkuwcc7 20 5 human human JJ cord-287123-ldkuwcc7 20 6 G g NN cord-287123-ldkuwcc7 20 7 protein protein NN cord-287123-ldkuwcc7 20 8 - - HYPH cord-287123-ldkuwcc7 20 9 coupled couple VBN cord-287123-ldkuwcc7 20 10 formyl formyl NNP cord-287123-ldkuwcc7 20 11 peptide peptide NN cord-287123-ldkuwcc7 20 12 receptors receptor NNS cord-287123-ldkuwcc7 20 13 have have VBP cord-287123-ldkuwcc7 20 14 been be VBN cord-287123-ldkuwcc7 20 15 cloned clone VBN cord-287123-ldkuwcc7 20 16 , , , cord-287123-ldkuwcc7 20 17 including include VBG cord-287123-ldkuwcc7 20 18 FPR1 FPR1 NNP cord-287123-ldkuwcc7 20 19 , , , cord-287123-ldkuwcc7 20 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 20 21 and and CC cord-287123-ldkuwcc7 20 22 FPR3 FPR3 NNP cord-287123-ldkuwcc7 20 23 [ [ -LRB- cord-287123-ldkuwcc7 20 24 8 8 CD cord-287123-ldkuwcc7 20 25 ] ] -RRB- cord-287123-ldkuwcc7 21 1 [ [ -LRB- cord-287123-ldkuwcc7 21 2 9 9 CD cord-287123-ldkuwcc7 21 3 ] ] -RRB- cord-287123-ldkuwcc7 21 4 [ [ -LRB- cord-287123-ldkuwcc7 21 5 10 10 CD cord-287123-ldkuwcc7 21 6 ] ] -RRB- cord-287123-ldkuwcc7 21 7 [ [ -LRB- cord-287123-ldkuwcc7 21 8 11 11 CD cord-287123-ldkuwcc7 21 9 ] ] -RRB- cord-287123-ldkuwcc7 21 10 [ [ -LRB- cord-287123-ldkuwcc7 21 11 12 12 CD cord-287123-ldkuwcc7 21 12 ] ] -RRB- cord-287123-ldkuwcc7 21 13 [ [ -LRB- cord-287123-ldkuwcc7 21 14 13 13 CD cord-287123-ldkuwcc7 21 15 ] ] -RRB- cord-287123-ldkuwcc7 21 16 . . . cord-287123-ldkuwcc7 22 1 Among among IN cord-287123-ldkuwcc7 22 2 them -PRON- PRP cord-287123-ldkuwcc7 22 3 , , , cord-287123-ldkuwcc7 22 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 22 5 and and CC cord-287123-ldkuwcc7 22 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 22 7 share share VBP cord-287123-ldkuwcc7 22 8 an an DT cord-287123-ldkuwcc7 22 9 overall overall JJ cord-287123-ldkuwcc7 22 10 high high JJ cord-287123-ldkuwcc7 22 11 sequence sequence NN cord-287123-ldkuwcc7 22 12 identity identity NN cord-287123-ldkuwcc7 22 13 ( ( -LRB- cord-287123-ldkuwcc7 22 14 Figure figure NN cord-287123-ldkuwcc7 22 15 1 1 CD cord-287123-ldkuwcc7 22 16 ) ) -RRB- cord-287123-ldkuwcc7 22 17 and and CC cord-287123-ldkuwcc7 22 18 certain certain JJ cord-287123-ldkuwcc7 22 19 overlapping overlapping JJ cord-287123-ldkuwcc7 22 20 functions function NNS cord-287123-ldkuwcc7 22 21 . . . cord-287123-ldkuwcc7 23 1 [ [ -LRB- cord-287123-ldkuwcc7 23 2 14 14 CD cord-287123-ldkuwcc7 23 3 ] ] -RRB- cord-287123-ldkuwcc7 23 4 in in IN cord-287123-ldkuwcc7 23 5 three three CD cord-287123-ldkuwcc7 23 6 FPR fpr NN cord-287123-ldkuwcc7 23 7 isoforms isoform NNS cord-287123-ldkuwcc7 23 8 are be VBP cord-287123-ldkuwcc7 23 9 shown show VBN cord-287123-ldkuwcc7 23 10 in in IN cord-287123-ldkuwcc7 23 11 color color NN cord-287123-ldkuwcc7 23 12 ; ; : cord-287123-ldkuwcc7 23 13 ( ( -LRB- cord-287123-ldkuwcc7 23 14 B b NN cord-287123-ldkuwcc7 23 15 ) ) -RRB- cord-287123-ldkuwcc7 23 16 Schematic schematic NN cord-287123-ldkuwcc7 23 17 diagram diagram NN cord-287123-ldkuwcc7 23 18 for for IN cord-287123-ldkuwcc7 23 19 the the DT cord-287123-ldkuwcc7 23 20 location location NN cord-287123-ldkuwcc7 23 21 of of IN cord-287123-ldkuwcc7 23 22 the the DT cord-287123-ldkuwcc7 23 23 positive positive JJ cord-287123-ldkuwcc7 23 24 selection selection NN cord-287123-ldkuwcc7 23 25 sites site NNS cord-287123-ldkuwcc7 23 26 in in IN cord-287123-ldkuwcc7 23 27 the the DT cord-287123-ldkuwcc7 23 28 formyl formyl NNP cord-287123-ldkuwcc7 23 29 peptide peptide NN cord-287123-ldkuwcc7 23 30 receptors receptor NNS cord-287123-ldkuwcc7 23 31 , , , cord-287123-ldkuwcc7 23 32 based base VBN cord-287123-ldkuwcc7 23 33 on on IN cord-287123-ldkuwcc7 23 34 the the DT cord-287123-ldkuwcc7 23 35 sequence sequence NN cord-287123-ldkuwcc7 23 36 of of IN cord-287123-ldkuwcc7 23 37 human human JJ cord-287123-ldkuwcc7 23 38 FPR1 FPR1 NNP cord-287123-ldkuwcc7 23 39 . . . cord-287123-ldkuwcc7 24 1 The the DT cord-287123-ldkuwcc7 24 2 amino amino NN cord-287123-ldkuwcc7 24 3 acids acid NNS cord-287123-ldkuwcc7 24 4 at at IN cord-287123-ldkuwcc7 24 5 these these DT cord-287123-ldkuwcc7 24 6 positions position NNS cord-287123-ldkuwcc7 24 7 in in IN cord-287123-ldkuwcc7 24 8 each each DT cord-287123-ldkuwcc7 24 9 of of IN cord-287123-ldkuwcc7 24 10 the the DT cord-287123-ldkuwcc7 24 11 three three CD cord-287123-ldkuwcc7 24 12 receptors receptor NNS cord-287123-ldkuwcc7 24 13 are be VBP cord-287123-ldkuwcc7 24 14 marked mark VBN cord-287123-ldkuwcc7 24 15 on on IN cord-287123-ldkuwcc7 24 16 the the DT cord-287123-ldkuwcc7 24 17 right right NN cord-287123-ldkuwcc7 24 18 . . . cord-287123-ldkuwcc7 25 1 FPR1 FPR1 NNP cord-287123-ldkuwcc7 25 2 and and CC cord-287123-ldkuwcc7 25 3 FPR2 FPR2 NNP cord-287123-ldkuwcc7 25 4 are be VBP cord-287123-ldkuwcc7 25 5 expressed express VBN cord-287123-ldkuwcc7 25 6 in in IN cord-287123-ldkuwcc7 25 7 both both DT cord-287123-ldkuwcc7 25 8 monocytes monocyte NNS cord-287123-ldkuwcc7 25 9 and and CC cord-287123-ldkuwcc7 25 10 neutrophils neutrophil NNS cord-287123-ldkuwcc7 25 11 , , , cord-287123-ldkuwcc7 25 12 while while IN cord-287123-ldkuwcc7 25 13 FPR3 FPR3 NNP cord-287123-ldkuwcc7 25 14 is be VBZ cord-287123-ldkuwcc7 25 15 found find VBN cord-287123-ldkuwcc7 25 16 in in IN cord-287123-ldkuwcc7 25 17 monocytes monocyte NNS cord-287123-ldkuwcc7 25 18 but but CC cord-287123-ldkuwcc7 25 19 not not RB cord-287123-ldkuwcc7 25 20 neutrophils neutrophil NNS cord-287123-ldkuwcc7 25 21 . . . cord-287123-ldkuwcc7 26 1 Besides besides IN cord-287123-ldkuwcc7 26 2 myeloid myeloid JJ cord-287123-ldkuwcc7 26 3 cells cell NNS cord-287123-ldkuwcc7 26 4 , , , cord-287123-ldkuwcc7 26 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 26 6 is be VBZ cord-287123-ldkuwcc7 26 7 expressed express VBN cord-287123-ldkuwcc7 26 8 in in IN cord-287123-ldkuwcc7 26 9 astrocytes astrocyte NNS cord-287123-ldkuwcc7 26 10 , , , cord-287123-ldkuwcc7 26 11 microglial microglial JJ cord-287123-ldkuwcc7 26 12 cells cell NNS cord-287123-ldkuwcc7 26 13 , , , cord-287123-ldkuwcc7 26 14 hepatocytes hepatocyte NNS cord-287123-ldkuwcc7 26 15 and and CC cord-287123-ldkuwcc7 26 16 immature immature JJ cord-287123-ldkuwcc7 26 17 dendritic dendritic JJ cord-287123-ldkuwcc7 26 18 cells cell NNS cord-287123-ldkuwcc7 26 19 . . . cord-287123-ldkuwcc7 27 1 FPR2 FPR2 NNP cord-287123-ldkuwcc7 27 2 shows show VBZ cord-287123-ldkuwcc7 27 3 an an DT cord-287123-ldkuwcc7 27 4 even even RB cord-287123-ldkuwcc7 27 5 wider wide JJR cord-287123-ldkuwcc7 27 6 distribution distribution NN cord-287123-ldkuwcc7 27 7 pattern pattern NN cord-287123-ldkuwcc7 27 8 than than IN cord-287123-ldkuwcc7 27 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 27 10 and and CC cord-287123-ldkuwcc7 27 11 is be VBZ cord-287123-ldkuwcc7 27 12 expressed express VBN cord-287123-ldkuwcc7 27 13 in in IN cord-287123-ldkuwcc7 27 14 a a DT cord-287123-ldkuwcc7 27 15 variety variety NN cord-287123-ldkuwcc7 27 16 of of IN cord-287123-ldkuwcc7 27 17 non non JJ cord-287123-ldkuwcc7 27 18 - - JJ cord-287123-ldkuwcc7 27 19 myeloid myeloid JJ cord-287123-ldkuwcc7 27 20 cells cell NNS cord-287123-ldkuwcc7 27 21 including include VBG cord-287123-ldkuwcc7 27 22 astrocytoma astrocytoma NN cord-287123-ldkuwcc7 27 23 cells cell NNS cord-287123-ldkuwcc7 27 24 , , , cord-287123-ldkuwcc7 27 25 epithelial epithelial JJ cord-287123-ldkuwcc7 27 26 cells cell NNS cord-287123-ldkuwcc7 27 27 , , , cord-287123-ldkuwcc7 27 28 hepatocytes hepatocyte NNS cord-287123-ldkuwcc7 27 29 , , , cord-287123-ldkuwcc7 27 30 microvascular microvascular JJ cord-287123-ldkuwcc7 27 31 endothelial endothelial JJ cord-287123-ldkuwcc7 27 32 cells cell NNS cord-287123-ldkuwcc7 27 33 , , , cord-287123-ldkuwcc7 27 34 neuroblastoma neuroblastoma NN cord-287123-ldkuwcc7 27 35 cells cell NNS cord-287123-ldkuwcc7 27 36 , , , cord-287123-ldkuwcc7 27 37 in in IN cord-287123-ldkuwcc7 27 38 addition addition NN cord-287123-ldkuwcc7 27 39 to to IN cord-287123-ldkuwcc7 27 40 phagocytic phagocytic JJ cord-287123-ldkuwcc7 27 41 leukocytes leukocyte NNS cord-287123-ldkuwcc7 27 42 . . . cord-287123-ldkuwcc7 28 1 In in IN cord-287123-ldkuwcc7 28 2 recent recent JJ cord-287123-ldkuwcc7 28 3 studies study NNS cord-287123-ldkuwcc7 28 4 , , , cord-287123-ldkuwcc7 28 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 28 6 has have VBZ cord-287123-ldkuwcc7 28 7 been be VBN cord-287123-ldkuwcc7 28 8 associated associate VBN cord-287123-ldkuwcc7 28 9 with with IN cord-287123-ldkuwcc7 28 10 anti anti JJ cord-287123-ldkuwcc7 28 11 - - JJ cord-287123-ldkuwcc7 28 12 bacterial bacterial JJ cord-287123-ldkuwcc7 28 13 inflammation inflammation NN cord-287123-ldkuwcc7 28 14 and and CC cord-287123-ldkuwcc7 28 15 metastasis metastasis NN cord-287123-ldkuwcc7 28 16 of of IN cord-287123-ldkuwcc7 28 17 malignant malignant JJ cord-287123-ldkuwcc7 28 18 glioma glioma NN cord-287123-ldkuwcc7 28 19 cells cell NNS cord-287123-ldkuwcc7 28 20 , , , cord-287123-ldkuwcc7 28 21 while while IN cord-287123-ldkuwcc7 28 22 FPR2 FPR2 NNP cord-287123-ldkuwcc7 28 23 is be VBZ cord-287123-ldkuwcc7 28 24 implicated implicate VBN cord-287123-ldkuwcc7 28 25 in in IN cord-287123-ldkuwcc7 28 26 the the DT cord-287123-ldkuwcc7 28 27 pathogenesis pathogenesis NN cord-287123-ldkuwcc7 28 28 of of IN cord-287123-ldkuwcc7 28 29 chronic chronic JJ cord-287123-ldkuwcc7 28 30 inflammatory inflammatory JJ cord-287123-ldkuwcc7 28 31 diseases disease NNS cord-287123-ldkuwcc7 28 32 such such JJ cord-287123-ldkuwcc7 28 33 as as IN cord-287123-ldkuwcc7 28 34 systemic systemic JJ cord-287123-ldkuwcc7 28 35 amyloidosis amyloidosis NN cord-287123-ldkuwcc7 28 36 , , , cord-287123-ldkuwcc7 28 37 Alzheimer Alzheimer NNP cord-287123-ldkuwcc7 28 38 's 's POS cord-287123-ldkuwcc7 28 39 disease disease NN cord-287123-ldkuwcc7 28 40 , , , cord-287123-ldkuwcc7 28 41 atherosclerosis atherosclerosis NN cord-287123-ldkuwcc7 28 42 , , , cord-287123-ldkuwcc7 28 43 systemic systemic JJ cord-287123-ldkuwcc7 28 44 lupus lupus NN cord-287123-ldkuwcc7 28 45 erythematosus erythematosus NN cord-287123-ldkuwcc7 28 46 and and CC cord-287123-ldkuwcc7 28 47 ovarian ovarian JJ cord-287123-ldkuwcc7 28 48 cancer cancer NN cord-287123-ldkuwcc7 28 49 metastasis metastasis NN cord-287123-ldkuwcc7 28 50 et et NNP cord-287123-ldkuwcc7 28 51 al al NNP cord-287123-ldkuwcc7 28 52 [ [ -LRB- cord-287123-ldkuwcc7 28 53 15 15 CD cord-287123-ldkuwcc7 28 54 ] ] -RRB- cord-287123-ldkuwcc7 28 55 [ [ -LRB- cord-287123-ldkuwcc7 28 56 16 16 CD cord-287123-ldkuwcc7 28 57 ] ] -RRB- cord-287123-ldkuwcc7 28 58 [ [ -LRB- cord-287123-ldkuwcc7 28 59 17 17 CD cord-287123-ldkuwcc7 28 60 ] ] -RRB- cord-287123-ldkuwcc7 28 61 [ [ -LRB- cord-287123-ldkuwcc7 28 62 18 18 CD cord-287123-ldkuwcc7 28 63 ] ] -RRB- cord-287123-ldkuwcc7 28 64 [ [ -LRB- cord-287123-ldkuwcc7 28 65 19 19 CD cord-287123-ldkuwcc7 28 66 ] ] -RRB- cord-287123-ldkuwcc7 28 67 . . . cord-287123-ldkuwcc7 29 1 More More JJR cord-287123-ldkuwcc7 29 2 examples example NNS cord-287123-ldkuwcc7 29 3 and and CC cord-287123-ldkuwcc7 29 4 details detail NNS cord-287123-ldkuwcc7 29 5 of of IN cord-287123-ldkuwcc7 29 6 FPR fpr NN cord-287123-ldkuwcc7 29 7 involvement involvement NN cord-287123-ldkuwcc7 29 8 in in IN cord-287123-ldkuwcc7 29 9 multiple multiple JJ cord-287123-ldkuwcc7 29 10 diseases disease NNS cord-287123-ldkuwcc7 29 11 are be VBP cord-287123-ldkuwcc7 29 12 provided provide VBN cord-287123-ldkuwcc7 29 13 in in IN cord-287123-ldkuwcc7 29 14 recent recent JJ cord-287123-ldkuwcc7 29 15 reviews review NNS cord-287123-ldkuwcc7 29 16 [ [ -LRB- cord-287123-ldkuwcc7 29 17 7 7 CD cord-287123-ldkuwcc7 29 18 , , , cord-287123-ldkuwcc7 29 19 20 20 CD cord-287123-ldkuwcc7 29 20 ] ] -RRB- cord-287123-ldkuwcc7 29 21 . . . cord-287123-ldkuwcc7 30 1 Since since IN cord-287123-ldkuwcc7 30 2 the the DT cord-287123-ldkuwcc7 30 3 human human JJ cord-287123-ldkuwcc7 30 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 30 5 gene gene NN cord-287123-ldkuwcc7 30 6 ( ( -LRB- cord-287123-ldkuwcc7 30 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 30 8 ) ) -RRB- cord-287123-ldkuwcc7 30 9 was be VBD cord-287123-ldkuwcc7 30 10 first first RB cord-287123-ldkuwcc7 30 11 cloned clone VBN cord-287123-ldkuwcc7 30 12 , , , cord-287123-ldkuwcc7 30 13 orthologs ortholog NNS cord-287123-ldkuwcc7 30 14 have have VBP cord-287123-ldkuwcc7 30 15 been be VBN cord-287123-ldkuwcc7 30 16 identified identify VBN cord-287123-ldkuwcc7 30 17 in in IN cord-287123-ldkuwcc7 30 18 other other JJ cord-287123-ldkuwcc7 30 19 mammalian mammalian JJ cord-287123-ldkuwcc7 30 20 species specie NNS cord-287123-ldkuwcc7 30 21 , , , cord-287123-ldkuwcc7 30 22 including include VBG cord-287123-ldkuwcc7 30 23 rabbits rabbit NNS cord-287123-ldkuwcc7 30 24 , , , cord-287123-ldkuwcc7 30 25 guinea guinea NN cord-287123-ldkuwcc7 30 26 pigs pig NNS cord-287123-ldkuwcc7 30 27 , , , cord-287123-ldkuwcc7 30 28 horses horse NNS cord-287123-ldkuwcc7 30 29 , , , cord-287123-ldkuwcc7 30 30 rats rat NNS cord-287123-ldkuwcc7 30 31 and and CC cord-287123-ldkuwcc7 30 32 mice mouse NNS cord-287123-ldkuwcc7 30 33 ( ( -LRB- cord-287123-ldkuwcc7 30 34 reviewed review VBN cord-287123-ldkuwcc7 30 35 in in IN cord-287123-ldkuwcc7 30 36 [ [ -LRB- cord-287123-ldkuwcc7 30 37 2 2 CD cord-287123-ldkuwcc7 30 38 ] ] -RRB- cord-287123-ldkuwcc7 30 39 ) ) -RRB- cord-287123-ldkuwcc7 30 40 . . . cord-287123-ldkuwcc7 31 1 The the DT cord-287123-ldkuwcc7 31 2 genes gene NNS cord-287123-ldkuwcc7 31 3 coding code VBG cord-287123-ldkuwcc7 31 4 for for IN cord-287123-ldkuwcc7 31 5 FPR fpr NN cord-287123-ldkuwcc7 31 6 members member NNS cord-287123-ldkuwcc7 31 7 comprise comprise VBP cord-287123-ldkuwcc7 31 8 a a DT cord-287123-ldkuwcc7 31 9 large large JJ cord-287123-ldkuwcc7 31 10 family family NN cord-287123-ldkuwcc7 31 11 that that WDT cord-287123-ldkuwcc7 31 12 implicates implicate VBZ cord-287123-ldkuwcc7 31 13 a a DT cord-287123-ldkuwcc7 31 14 complex complex JJ cord-287123-ldkuwcc7 31 15 evolutionary evolutionary JJ cord-287123-ldkuwcc7 31 16 path path NN cord-287123-ldkuwcc7 31 17 with with IN cord-287123-ldkuwcc7 31 18 evidence evidence NN cord-287123-ldkuwcc7 31 19 of of IN cord-287123-ldkuwcc7 31 20 positive positive JJ cord-287123-ldkuwcc7 31 21 selection selection NN cord-287123-ldkuwcc7 31 22 [ [ -LRB- cord-287123-ldkuwcc7 31 23 14 14 CD cord-287123-ldkuwcc7 31 24 ] ] -RRB- cord-287123-ldkuwcc7 31 25 . . . cord-287123-ldkuwcc7 32 1 Despite despite IN cord-287123-ldkuwcc7 32 2 overall overall JJ cord-287123-ldkuwcc7 32 3 sequence sequence NN cord-287123-ldkuwcc7 32 4 homology homology NN cord-287123-ldkuwcc7 32 5 , , , cord-287123-ldkuwcc7 32 6 these these DT cord-287123-ldkuwcc7 32 7 genes gene NNS cord-287123-ldkuwcc7 32 8 vary vary VBP cord-287123-ldkuwcc7 32 9 considerably considerably RB cord-287123-ldkuwcc7 32 10 in in IN cord-287123-ldkuwcc7 32 11 their -PRON- PRP$ cord-287123-ldkuwcc7 32 12 numbers number NNS cord-287123-ldkuwcc7 32 13 and and CC cord-287123-ldkuwcc7 32 14 sequences sequence NNS cord-287123-ldkuwcc7 32 15 between between IN cord-287123-ldkuwcc7 32 16 humans human NNS cord-287123-ldkuwcc7 32 17 and and CC cord-287123-ldkuwcc7 32 18 other other JJ cord-287123-ldkuwcc7 32 19 species specie NNS cord-287123-ldkuwcc7 32 20 . . . cord-287123-ldkuwcc7 33 1 For for IN cord-287123-ldkuwcc7 33 2 example example NN cord-287123-ldkuwcc7 33 3 , , , cord-287123-ldkuwcc7 33 4 the the DT cord-287123-ldkuwcc7 33 5 mouse mouse NN cord-287123-ldkuwcc7 33 6 FPR FPR NNP cord-287123-ldkuwcc7 33 7 gene gene NN cord-287123-ldkuwcc7 33 8 family family NN cord-287123-ldkuwcc7 33 9 has have VBZ cord-287123-ldkuwcc7 33 10 eight eight CD cord-287123-ldkuwcc7 33 11 known know VBN cord-287123-ldkuwcc7 33 12 members member NNS cord-287123-ldkuwcc7 33 13 ( ( -LRB- cord-287123-ldkuwcc7 33 14 mFpr1 mfpr1 UH cord-287123-ldkuwcc7 33 15 , , , cord-287123-ldkuwcc7 33 16 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 33 17 , , , cord-287123-ldkuwcc7 33 18 mFpr mFpr NNP cord-287123-ldkuwcc7 33 19 - - HYPH cord-287123-ldkuwcc7 33 20 rs1 rs1 NNP cord-287123-ldkuwcc7 33 21 , , , cord-287123-ldkuwcc7 33 22 mFpr mfpr JJ cord-287123-ldkuwcc7 33 23 - - HYPH cord-287123-ldkuwcc7 33 24 rs3 rs3 JJ cord-287123-ldkuwcc7 33 25 , , , cord-287123-ldkuwcc7 33 26 mFpr mFpr NNP cord-287123-ldkuwcc7 33 27 - - HYPH cord-287123-ldkuwcc7 33 28 rs4 rs4 NNP cord-287123-ldkuwcc7 33 29 , , , cord-287123-ldkuwcc7 33 30 mFpr mFpr NNP cord-287123-ldkuwcc7 33 31 - - HYPH cord-287123-ldkuwcc7 33 32 rs6 rs6 NNP cord-287123-ldkuwcc7 33 33 , , , cord-287123-ldkuwcc7 33 34 mFpr mfpr JJ cord-287123-ldkuwcc7 33 35 - - HYPH cord-287123-ldkuwcc7 33 36 rs7 rs7 JJ cord-287123-ldkuwcc7 33 37 and and CC cord-287123-ldkuwcc7 33 38 mFpr mfpr JJ cord-287123-ldkuwcc7 33 39 - - HYPH cord-287123-ldkuwcc7 33 40 rs8 rs8 NN cord-287123-ldkuwcc7 33 41 ) ) -RRB- cord-287123-ldkuwcc7 33 42 clustered cluster VBN cord-287123-ldkuwcc7 33 43 on on IN cord-287123-ldkuwcc7 33 44 mouse mouse NN cord-287123-ldkuwcc7 33 45 chromosome chromosome NN cord-287123-ldkuwcc7 33 46 17A3.2 17a3.2 CD cord-287123-ldkuwcc7 33 47 . . . cord-287123-ldkuwcc7 34 1 Among among IN cord-287123-ldkuwcc7 34 2 these these DT cord-287123-ldkuwcc7 34 3 genes gene NNS cord-287123-ldkuwcc7 34 4 , , , cord-287123-ldkuwcc7 34 5 mFpr mFpr NNP cord-287123-ldkuwcc7 34 6 - - HYPH cord-287123-ldkuwcc7 34 7 rs5 rs5 NNP cord-287123-ldkuwcc7 34 8 ( ( -LRB- cord-287123-ldkuwcc7 34 9 ψmFpr ψmfpr NN cord-287123-ldkuwcc7 34 10 - - HYPH cord-287123-ldkuwcc7 34 11 rs3 rs3 NNP cord-287123-ldkuwcc7 34 12 ) ) -RRB- cord-287123-ldkuwcc7 34 13 is be VBZ cord-287123-ldkuwcc7 34 14 found find VBN cord-287123-ldkuwcc7 34 15 as as IN cord-287123-ldkuwcc7 34 16 a a DT cord-287123-ldkuwcc7 34 17 pseudogene pseudogene NN cord-287123-ldkuwcc7 34 18 that that WDT cord-287123-ldkuwcc7 34 19 does do VBZ cord-287123-ldkuwcc7 34 20 not not RB cord-287123-ldkuwcc7 34 21 code code VB cord-287123-ldkuwcc7 34 22 for for IN cord-287123-ldkuwcc7 34 23 a a DT cord-287123-ldkuwcc7 34 24 functional functional JJ cord-287123-ldkuwcc7 34 25 receptor receptor NN cord-287123-ldkuwcc7 34 26 . . . cord-287123-ldkuwcc7 35 1 Although although IN cord-287123-ldkuwcc7 35 2 several several JJ cord-287123-ldkuwcc7 35 3 mouse mouse NN cord-287123-ldkuwcc7 35 4 Fpr Fpr NNP cord-287123-ldkuwcc7 35 5 genes gene NNS cord-287123-ldkuwcc7 35 6 are be VBP cord-287123-ldkuwcc7 35 7 present present JJ cord-287123-ldkuwcc7 35 8 in in IN cord-287123-ldkuwcc7 35 9 neutrophils neutrophil NNS cord-287123-ldkuwcc7 35 10 , , , cord-287123-ldkuwcc7 35 11 work work VB cord-287123-ldkuwcc7 35 12 on on IN cord-287123-ldkuwcc7 35 13 mFprs mFprs NNP cord-287123-ldkuwcc7 35 14 has have VBZ cord-287123-ldkuwcc7 35 15 been be VBN cord-287123-ldkuwcc7 35 16 focused focus VBN cord-287123-ldkuwcc7 35 17 mostly mostly RB cord-287123-ldkuwcc7 35 18 on on IN cord-287123-ldkuwcc7 35 19 the the DT cord-287123-ldkuwcc7 35 20 gene gene NN cord-287123-ldkuwcc7 35 21 products product NNS cord-287123-ldkuwcc7 35 22 of of IN cord-287123-ldkuwcc7 35 23 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 35 24 and and CC cord-287123-ldkuwcc7 35 25 mFpr2 mFpr2 NNP cord-287123-ldkuwcc7 35 26 , , , cord-287123-ldkuwcc7 35 27 which which WDT cord-287123-ldkuwcc7 35 28 are be VBP cord-287123-ldkuwcc7 35 29 widely widely RB cord-287123-ldkuwcc7 35 30 expressed express VBN cord-287123-ldkuwcc7 35 31 in in IN cord-287123-ldkuwcc7 35 32 mouse mouse NN cord-287123-ldkuwcc7 35 33 phagocytic phagocytic JJ cord-287123-ldkuwcc7 35 34 leukocytes leukocyte NNS cord-287123-ldkuwcc7 35 35 and and CC cord-287123-ldkuwcc7 35 36 show show VBP cord-287123-ldkuwcc7 35 37 high high JJ cord-287123-ldkuwcc7 35 38 similarity similarity NN cord-287123-ldkuwcc7 35 39 to to IN cord-287123-ldkuwcc7 35 40 their -PRON- PRP$ cord-287123-ldkuwcc7 35 41 human human JJ cord-287123-ldkuwcc7 35 42 counterparts counterpart NNS cord-287123-ldkuwcc7 35 43 . . . cord-287123-ldkuwcc7 36 1 Targeted target VBN cord-287123-ldkuwcc7 36 2 deletion deletion NN cord-287123-ldkuwcc7 36 3 of of IN cord-287123-ldkuwcc7 36 4 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 36 5 or or CC cord-287123-ldkuwcc7 36 6 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 36 7 renders render VBZ cord-287123-ldkuwcc7 36 8 mice mouse NNS cord-287123-ldkuwcc7 36 9 more more RBR cord-287123-ldkuwcc7 36 10 susceptible susceptible JJ cord-287123-ldkuwcc7 36 11 to to IN cord-287123-ldkuwcc7 36 12 bacterial bacterial JJ cord-287123-ldkuwcc7 36 13 infection infection NN cord-287123-ldkuwcc7 36 14 without without IN cord-287123-ldkuwcc7 36 15 changing change VBG cord-287123-ldkuwcc7 36 16 their -PRON- PRP$ cord-287123-ldkuwcc7 36 17 viability viability NN cord-287123-ldkuwcc7 36 18 and and CC cord-287123-ldkuwcc7 36 19 fertility fertility NN cord-287123-ldkuwcc7 36 20 [ [ -LRB- cord-287123-ldkuwcc7 36 21 21 21 CD cord-287123-ldkuwcc7 36 22 , , , cord-287123-ldkuwcc7 36 23 22 22 CD cord-287123-ldkuwcc7 36 24 ] ] -RRB- cord-287123-ldkuwcc7 36 25 . . . cord-287123-ldkuwcc7 37 1 Under under IN cord-287123-ldkuwcc7 37 2 unstimulated unstimulated JJ cord-287123-ldkuwcc7 37 3 conditions condition NNS cord-287123-ldkuwcc7 37 4 , , , cord-287123-ldkuwcc7 37 5 mice mouse NNS cord-287123-ldkuwcc7 37 6 lacking lack VBG cord-287123-ldkuwcc7 37 7 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 37 8 or or CC cord-287123-ldkuwcc7 37 9 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 37 10 behave behave VB cord-287123-ldkuwcc7 37 11 normally normally RB cord-287123-ldkuwcc7 37 12 . . . cord-287123-ldkuwcc7 38 1 However however RB cord-287123-ldkuwcc7 38 2 , , , cord-287123-ldkuwcc7 38 3 in in IN cord-287123-ldkuwcc7 38 4 models model NNS cord-287123-ldkuwcc7 38 5 of of IN cord-287123-ldkuwcc7 38 6 human human JJ cord-287123-ldkuwcc7 38 7 diseases disease NNS cord-287123-ldkuwcc7 38 8 , , , cord-287123-ldkuwcc7 38 9 both both DT cord-287123-ldkuwcc7 38 10 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 38 11 −/− −/− NNP cord-287123-ldkuwcc7 38 12 and and CC cord-287123-ldkuwcc7 38 13 mFpr2 mFpr2 NNP cord-287123-ldkuwcc7 38 14 −/− −/− NNP cord-287123-ldkuwcc7 38 15 mice mouse NNS cord-287123-ldkuwcc7 38 16 respond respond VBP cord-287123-ldkuwcc7 38 17 differently differently RB cord-287123-ldkuwcc7 38 18 from from IN cord-287123-ldkuwcc7 38 19 their -PRON- PRP$ cord-287123-ldkuwcc7 38 20 wildtype wildtype JJ cord-287123-ldkuwcc7 38 21 littermates littermate NNS cord-287123-ldkuwcc7 38 22 , , , cord-287123-ldkuwcc7 38 23 [ [ -LRB- cord-287123-ldkuwcc7 38 24 14 14 CD cord-287123-ldkuwcc7 38 25 ] ] -RRB- cord-287123-ldkuwcc7 39 1 in in IN cord-287123-ldkuwcc7 39 2 three three CD cord-287123-ldkuwcc7 39 3 FPR fpr NN cord-287123-ldkuwcc7 39 4 isoforms isoform NNS cord-287123-ldkuwcc7 39 5 are be VBP cord-287123-ldkuwcc7 39 6 shown show VBN cord-287123-ldkuwcc7 39 7 in in IN cord-287123-ldkuwcc7 39 8 color color NN cord-287123-ldkuwcc7 39 9 ; ; : cord-287123-ldkuwcc7 39 10 ( ( -LRB- cord-287123-ldkuwcc7 39 11 B b NN cord-287123-ldkuwcc7 39 12 ) ) -RRB- cord-287123-ldkuwcc7 39 13 Schematic schematic NN cord-287123-ldkuwcc7 39 14 diagram diagram NN cord-287123-ldkuwcc7 39 15 for for IN cord-287123-ldkuwcc7 39 16 the the DT cord-287123-ldkuwcc7 39 17 location location NN cord-287123-ldkuwcc7 39 18 of of IN cord-287123-ldkuwcc7 39 19 the the DT cord-287123-ldkuwcc7 39 20 positive positive JJ cord-287123-ldkuwcc7 39 21 selection selection NN cord-287123-ldkuwcc7 39 22 sites site NNS cord-287123-ldkuwcc7 39 23 in in IN cord-287123-ldkuwcc7 39 24 the the DT cord-287123-ldkuwcc7 39 25 formyl formyl NNP cord-287123-ldkuwcc7 39 26 peptide peptide NN cord-287123-ldkuwcc7 39 27 receptors receptor NNS cord-287123-ldkuwcc7 39 28 , , , cord-287123-ldkuwcc7 39 29 based base VBN cord-287123-ldkuwcc7 39 30 on on IN cord-287123-ldkuwcc7 39 31 the the DT cord-287123-ldkuwcc7 39 32 sequence sequence NN cord-287123-ldkuwcc7 39 33 of of IN cord-287123-ldkuwcc7 39 34 human human JJ cord-287123-ldkuwcc7 39 35 FPR1 FPR1 NNP cord-287123-ldkuwcc7 39 36 . . . cord-287123-ldkuwcc7 40 1 The the DT cord-287123-ldkuwcc7 40 2 amino amino NN cord-287123-ldkuwcc7 40 3 acids acid NNS cord-287123-ldkuwcc7 40 4 at at IN cord-287123-ldkuwcc7 40 5 these these DT cord-287123-ldkuwcc7 40 6 positions position NNS cord-287123-ldkuwcc7 40 7 in in IN cord-287123-ldkuwcc7 40 8 each each DT cord-287123-ldkuwcc7 40 9 of of IN cord-287123-ldkuwcc7 40 10 the the DT cord-287123-ldkuwcc7 40 11 three three CD cord-287123-ldkuwcc7 40 12 receptors receptor NNS cord-287123-ldkuwcc7 40 13 are be VBP cord-287123-ldkuwcc7 40 14 marked mark VBN cord-287123-ldkuwcc7 40 15 on on IN cord-287123-ldkuwcc7 40 16 the the DT cord-287123-ldkuwcc7 40 17 right right NN cord-287123-ldkuwcc7 40 18 . . . cord-287123-ldkuwcc7 41 1 FPR1 FPR1 NNP cord-287123-ldkuwcc7 41 2 and and CC cord-287123-ldkuwcc7 41 3 FPR2 FPR2 NNP cord-287123-ldkuwcc7 41 4 are be VBP cord-287123-ldkuwcc7 41 5 expressed express VBN cord-287123-ldkuwcc7 41 6 in in IN cord-287123-ldkuwcc7 41 7 both both DT cord-287123-ldkuwcc7 41 8 monocytes monocyte NNS cord-287123-ldkuwcc7 41 9 and and CC cord-287123-ldkuwcc7 41 10 neutrophils neutrophil NNS cord-287123-ldkuwcc7 41 11 , , , cord-287123-ldkuwcc7 41 12 while while IN cord-287123-ldkuwcc7 41 13 FPR3 FPR3 NNP cord-287123-ldkuwcc7 41 14 is be VBZ cord-287123-ldkuwcc7 41 15 found find VBN cord-287123-ldkuwcc7 41 16 in in IN cord-287123-ldkuwcc7 41 17 monocytes monocyte NNS cord-287123-ldkuwcc7 41 18 but but CC cord-287123-ldkuwcc7 41 19 not not RB cord-287123-ldkuwcc7 41 20 neutrophils neutrophil NNS cord-287123-ldkuwcc7 41 21 . . . cord-287123-ldkuwcc7 42 1 Besides besides IN cord-287123-ldkuwcc7 42 2 myeloid myeloid JJ cord-287123-ldkuwcc7 42 3 cells cell NNS cord-287123-ldkuwcc7 42 4 , , , cord-287123-ldkuwcc7 42 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 42 6 is be VBZ cord-287123-ldkuwcc7 42 7 expressed express VBN cord-287123-ldkuwcc7 42 8 in in IN cord-287123-ldkuwcc7 42 9 astrocytes astrocyte NNS cord-287123-ldkuwcc7 42 10 , , , cord-287123-ldkuwcc7 42 11 microglial microglial JJ cord-287123-ldkuwcc7 42 12 cells cell NNS cord-287123-ldkuwcc7 42 13 , , , cord-287123-ldkuwcc7 42 14 hepatocytes hepatocyte NNS cord-287123-ldkuwcc7 42 15 and and CC cord-287123-ldkuwcc7 42 16 immature immature JJ cord-287123-ldkuwcc7 42 17 dendritic dendritic JJ cord-287123-ldkuwcc7 42 18 cells cell NNS cord-287123-ldkuwcc7 42 19 . . . cord-287123-ldkuwcc7 43 1 FPR2 FPR2 NNP cord-287123-ldkuwcc7 43 2 shows show VBZ cord-287123-ldkuwcc7 43 3 an an DT cord-287123-ldkuwcc7 43 4 even even RB cord-287123-ldkuwcc7 43 5 wider wide JJR cord-287123-ldkuwcc7 43 6 distribution distribution NN cord-287123-ldkuwcc7 43 7 pattern pattern NN cord-287123-ldkuwcc7 43 8 than than IN cord-287123-ldkuwcc7 43 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 43 10 and and CC cord-287123-ldkuwcc7 43 11 is be VBZ cord-287123-ldkuwcc7 43 12 expressed express VBN cord-287123-ldkuwcc7 43 13 in in IN cord-287123-ldkuwcc7 43 14 a a DT cord-287123-ldkuwcc7 43 15 variety variety NN cord-287123-ldkuwcc7 43 16 of of IN cord-287123-ldkuwcc7 43 17 non non JJ cord-287123-ldkuwcc7 43 18 - - JJ cord-287123-ldkuwcc7 43 19 myeloid myeloid JJ cord-287123-ldkuwcc7 43 20 cells cell NNS cord-287123-ldkuwcc7 43 21 including include VBG cord-287123-ldkuwcc7 43 22 astrocytoma astrocytoma NN cord-287123-ldkuwcc7 43 23 cells cell NNS cord-287123-ldkuwcc7 43 24 , , , cord-287123-ldkuwcc7 43 25 epithelial epithelial JJ cord-287123-ldkuwcc7 43 26 cells cell NNS cord-287123-ldkuwcc7 43 27 , , , cord-287123-ldkuwcc7 43 28 hepatocytes hepatocyte NNS cord-287123-ldkuwcc7 43 29 , , , cord-287123-ldkuwcc7 43 30 microvascular microvascular JJ cord-287123-ldkuwcc7 43 31 endothelial endothelial JJ cord-287123-ldkuwcc7 43 32 cells cell NNS cord-287123-ldkuwcc7 43 33 , , , cord-287123-ldkuwcc7 43 34 neuroblastoma neuroblastoma NN cord-287123-ldkuwcc7 43 35 cells cell NNS cord-287123-ldkuwcc7 43 36 , , , cord-287123-ldkuwcc7 43 37 in in IN cord-287123-ldkuwcc7 43 38 addition addition NN cord-287123-ldkuwcc7 43 39 to to IN cord-287123-ldkuwcc7 43 40 phagocytic phagocytic JJ cord-287123-ldkuwcc7 43 41 leukocytes leukocyte NNS cord-287123-ldkuwcc7 43 42 . . . cord-287123-ldkuwcc7 44 1 In in IN cord-287123-ldkuwcc7 44 2 recent recent JJ cord-287123-ldkuwcc7 44 3 studies study NNS cord-287123-ldkuwcc7 44 4 , , , cord-287123-ldkuwcc7 44 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 44 6 has have VBZ cord-287123-ldkuwcc7 44 7 been be VBN cord-287123-ldkuwcc7 44 8 associated associate VBN cord-287123-ldkuwcc7 44 9 with with IN cord-287123-ldkuwcc7 44 10 anti anti JJ cord-287123-ldkuwcc7 44 11 - - JJ cord-287123-ldkuwcc7 44 12 bacterial bacterial JJ cord-287123-ldkuwcc7 44 13 inflammation inflammation NN cord-287123-ldkuwcc7 44 14 and and CC cord-287123-ldkuwcc7 44 15 metastasis metastasis NN cord-287123-ldkuwcc7 44 16 of of IN cord-287123-ldkuwcc7 44 17 malignant malignant JJ cord-287123-ldkuwcc7 44 18 glioma glioma NN cord-287123-ldkuwcc7 44 19 cells cell NNS cord-287123-ldkuwcc7 44 20 , , , cord-287123-ldkuwcc7 44 21 while while IN cord-287123-ldkuwcc7 44 22 FPR2 FPR2 NNP cord-287123-ldkuwcc7 44 23 is be VBZ cord-287123-ldkuwcc7 44 24 implicated implicate VBN cord-287123-ldkuwcc7 44 25 in in IN cord-287123-ldkuwcc7 44 26 the the DT cord-287123-ldkuwcc7 44 27 pathogenesis pathogenesis NN cord-287123-ldkuwcc7 44 28 of of IN cord-287123-ldkuwcc7 44 29 chronic chronic JJ cord-287123-ldkuwcc7 44 30 inflammatory inflammatory JJ cord-287123-ldkuwcc7 44 31 diseases disease NNS cord-287123-ldkuwcc7 44 32 such such JJ cord-287123-ldkuwcc7 44 33 as as IN cord-287123-ldkuwcc7 44 34 systemic systemic JJ cord-287123-ldkuwcc7 44 35 amyloidosis amyloidosis NN cord-287123-ldkuwcc7 44 36 , , , cord-287123-ldkuwcc7 44 37 Alzheimer Alzheimer NNP cord-287123-ldkuwcc7 44 38 's 's POS cord-287123-ldkuwcc7 44 39 disease disease NN cord-287123-ldkuwcc7 44 40 , , , cord-287123-ldkuwcc7 44 41 atherosclerosis atherosclerosis NN cord-287123-ldkuwcc7 44 42 , , , cord-287123-ldkuwcc7 44 43 systemic systemic JJ cord-287123-ldkuwcc7 44 44 lupus lupus NN cord-287123-ldkuwcc7 44 45 erythematosus erythematosus NN cord-287123-ldkuwcc7 44 46 and and CC cord-287123-ldkuwcc7 44 47 ovarian ovarian JJ cord-287123-ldkuwcc7 44 48 cancer cancer NN cord-287123-ldkuwcc7 44 49 metastasis metastasis NN cord-287123-ldkuwcc7 44 50 et et NNP cord-287123-ldkuwcc7 44 51 al al NNP cord-287123-ldkuwcc7 44 52 . . . cord-287123-ldkuwcc7 45 1 [ [ -LRB- cord-287123-ldkuwcc7 45 2 15 15 CD cord-287123-ldkuwcc7 45 3 ] ] -RRB- cord-287123-ldkuwcc7 45 4 [ [ -LRB- cord-287123-ldkuwcc7 45 5 16 16 CD cord-287123-ldkuwcc7 45 6 ] ] -RRB- cord-287123-ldkuwcc7 45 7 [ [ -LRB- cord-287123-ldkuwcc7 45 8 17 17 CD cord-287123-ldkuwcc7 45 9 ] ] -RRB- cord-287123-ldkuwcc7 45 10 [ [ -LRB- cord-287123-ldkuwcc7 45 11 18 18 CD cord-287123-ldkuwcc7 45 12 ] ] -RRB- cord-287123-ldkuwcc7 45 13 [ [ -LRB- cord-287123-ldkuwcc7 45 14 19 19 CD cord-287123-ldkuwcc7 45 15 ] ] -RRB- cord-287123-ldkuwcc7 45 16 . . . cord-287123-ldkuwcc7 46 1 More More JJR cord-287123-ldkuwcc7 46 2 examples example NNS cord-287123-ldkuwcc7 46 3 and and CC cord-287123-ldkuwcc7 46 4 details detail NNS cord-287123-ldkuwcc7 46 5 of of IN cord-287123-ldkuwcc7 46 6 FPR fpr NN cord-287123-ldkuwcc7 46 7 involvement involvement NN cord-287123-ldkuwcc7 46 8 in in IN cord-287123-ldkuwcc7 46 9 multiple multiple JJ cord-287123-ldkuwcc7 46 10 diseases disease NNS cord-287123-ldkuwcc7 46 11 are be VBP cord-287123-ldkuwcc7 46 12 provided provide VBN cord-287123-ldkuwcc7 46 13 in in IN cord-287123-ldkuwcc7 46 14 recent recent JJ cord-287123-ldkuwcc7 46 15 reviews review NNS cord-287123-ldkuwcc7 46 16 [ [ -LRB- cord-287123-ldkuwcc7 46 17 7 7 CD cord-287123-ldkuwcc7 46 18 , , , cord-287123-ldkuwcc7 46 19 20 20 CD cord-287123-ldkuwcc7 46 20 ] ] -RRB- cord-287123-ldkuwcc7 46 21 . . . cord-287123-ldkuwcc7 47 1 Since since IN cord-287123-ldkuwcc7 47 2 the the DT cord-287123-ldkuwcc7 47 3 human human JJ cord-287123-ldkuwcc7 47 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 47 5 gene gene NN cord-287123-ldkuwcc7 47 6 ( ( -LRB- cord-287123-ldkuwcc7 47 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 47 8 ) ) -RRB- cord-287123-ldkuwcc7 47 9 was be VBD cord-287123-ldkuwcc7 47 10 first first RB cord-287123-ldkuwcc7 47 11 cloned clone VBN cord-287123-ldkuwcc7 47 12 , , , cord-287123-ldkuwcc7 47 13 orthologs ortholog NNS cord-287123-ldkuwcc7 47 14 have have VBP cord-287123-ldkuwcc7 47 15 been be VBN cord-287123-ldkuwcc7 47 16 identified identify VBN cord-287123-ldkuwcc7 47 17 in in IN cord-287123-ldkuwcc7 47 18 other other JJ cord-287123-ldkuwcc7 47 19 mammalian mammalian JJ cord-287123-ldkuwcc7 47 20 species specie NNS cord-287123-ldkuwcc7 47 21 , , , cord-287123-ldkuwcc7 47 22 including include VBG cord-287123-ldkuwcc7 47 23 rabbits rabbit NNS cord-287123-ldkuwcc7 47 24 , , , cord-287123-ldkuwcc7 47 25 guinea guinea NN cord-287123-ldkuwcc7 47 26 pigs pig NNS cord-287123-ldkuwcc7 47 27 , , , cord-287123-ldkuwcc7 47 28 horses horse NNS cord-287123-ldkuwcc7 47 29 , , , cord-287123-ldkuwcc7 47 30 rats rat NNS cord-287123-ldkuwcc7 47 31 and and CC cord-287123-ldkuwcc7 47 32 mice mouse NNS cord-287123-ldkuwcc7 47 33 ( ( -LRB- cord-287123-ldkuwcc7 47 34 reviewed review VBN cord-287123-ldkuwcc7 47 35 in in IN cord-287123-ldkuwcc7 47 36 [ [ -LRB- cord-287123-ldkuwcc7 47 37 2 2 CD cord-287123-ldkuwcc7 47 38 ] ] -RRB- cord-287123-ldkuwcc7 47 39 ) ) -RRB- cord-287123-ldkuwcc7 47 40 . . . cord-287123-ldkuwcc7 48 1 The the DT cord-287123-ldkuwcc7 48 2 genes gene NNS cord-287123-ldkuwcc7 48 3 coding code VBG cord-287123-ldkuwcc7 48 4 for for IN cord-287123-ldkuwcc7 48 5 FPR fpr NN cord-287123-ldkuwcc7 48 6 members member NNS cord-287123-ldkuwcc7 48 7 comprise comprise VBP cord-287123-ldkuwcc7 48 8 a a DT cord-287123-ldkuwcc7 48 9 large large JJ cord-287123-ldkuwcc7 48 10 family family NN cord-287123-ldkuwcc7 48 11 that that WDT cord-287123-ldkuwcc7 48 12 implicates implicate VBZ cord-287123-ldkuwcc7 48 13 a a DT cord-287123-ldkuwcc7 48 14 complex complex JJ cord-287123-ldkuwcc7 48 15 evolutionary evolutionary JJ cord-287123-ldkuwcc7 48 16 path path NN cord-287123-ldkuwcc7 48 17 with with IN cord-287123-ldkuwcc7 48 18 evidence evidence NN cord-287123-ldkuwcc7 48 19 of of IN cord-287123-ldkuwcc7 48 20 positive positive JJ cord-287123-ldkuwcc7 48 21 selection selection NN cord-287123-ldkuwcc7 48 22 [ [ -LRB- cord-287123-ldkuwcc7 48 23 14 14 CD cord-287123-ldkuwcc7 48 24 ] ] -RRB- cord-287123-ldkuwcc7 48 25 . . . cord-287123-ldkuwcc7 49 1 Despite despite IN cord-287123-ldkuwcc7 49 2 overall overall JJ cord-287123-ldkuwcc7 49 3 sequence sequence NN cord-287123-ldkuwcc7 49 4 homology homology NN cord-287123-ldkuwcc7 49 5 , , , cord-287123-ldkuwcc7 49 6 these these DT cord-287123-ldkuwcc7 49 7 genes gene NNS cord-287123-ldkuwcc7 49 8 vary vary VBP cord-287123-ldkuwcc7 49 9 considerably considerably RB cord-287123-ldkuwcc7 49 10 in in IN cord-287123-ldkuwcc7 49 11 their -PRON- PRP$ cord-287123-ldkuwcc7 49 12 numbers number NNS cord-287123-ldkuwcc7 49 13 and and CC cord-287123-ldkuwcc7 49 14 sequences sequence NNS cord-287123-ldkuwcc7 49 15 between between IN cord-287123-ldkuwcc7 49 16 humans human NNS cord-287123-ldkuwcc7 49 17 and and CC cord-287123-ldkuwcc7 49 18 other other JJ cord-287123-ldkuwcc7 49 19 species specie NNS cord-287123-ldkuwcc7 49 20 . . . cord-287123-ldkuwcc7 50 1 For for IN cord-287123-ldkuwcc7 50 2 example example NN cord-287123-ldkuwcc7 50 3 , , , cord-287123-ldkuwcc7 50 4 the the DT cord-287123-ldkuwcc7 50 5 mouse mouse NN cord-287123-ldkuwcc7 50 6 FPR FPR NNP cord-287123-ldkuwcc7 50 7 gene gene NN cord-287123-ldkuwcc7 50 8 family family NN cord-287123-ldkuwcc7 50 9 has have VBZ cord-287123-ldkuwcc7 50 10 eight eight CD cord-287123-ldkuwcc7 50 11 known know VBN cord-287123-ldkuwcc7 50 12 members member NNS cord-287123-ldkuwcc7 50 13 ( ( -LRB- cord-287123-ldkuwcc7 50 14 mFpr1 mfpr1 UH cord-287123-ldkuwcc7 50 15 , , , cord-287123-ldkuwcc7 50 16 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 50 17 , , , cord-287123-ldkuwcc7 50 18 mFpr mFpr NNP cord-287123-ldkuwcc7 50 19 - - HYPH cord-287123-ldkuwcc7 50 20 rs1 rs1 NNP cord-287123-ldkuwcc7 50 21 , , , cord-287123-ldkuwcc7 50 22 mFpr mfpr JJ cord-287123-ldkuwcc7 50 23 - - HYPH cord-287123-ldkuwcc7 50 24 rs3 rs3 JJ cord-287123-ldkuwcc7 50 25 , , , cord-287123-ldkuwcc7 50 26 mFpr mFpr NNP cord-287123-ldkuwcc7 50 27 - - HYPH cord-287123-ldkuwcc7 50 28 rs4 rs4 NNP cord-287123-ldkuwcc7 50 29 , , , cord-287123-ldkuwcc7 50 30 mFpr mFpr NNP cord-287123-ldkuwcc7 50 31 - - HYPH cord-287123-ldkuwcc7 50 32 rs6 rs6 NNP cord-287123-ldkuwcc7 50 33 , , , cord-287123-ldkuwcc7 50 34 mFpr mfpr JJ cord-287123-ldkuwcc7 50 35 - - HYPH cord-287123-ldkuwcc7 50 36 rs7 rs7 JJ cord-287123-ldkuwcc7 50 37 and and CC cord-287123-ldkuwcc7 50 38 mFpr mfpr JJ cord-287123-ldkuwcc7 50 39 - - HYPH cord-287123-ldkuwcc7 50 40 rs8 rs8 NN cord-287123-ldkuwcc7 50 41 ) ) -RRB- cord-287123-ldkuwcc7 50 42 clustered cluster VBN cord-287123-ldkuwcc7 50 43 on on IN cord-287123-ldkuwcc7 50 44 mouse mouse NN cord-287123-ldkuwcc7 50 45 chromosome chromosome NN cord-287123-ldkuwcc7 50 46 17A3.2 17a3.2 CD cord-287123-ldkuwcc7 50 47 . . . cord-287123-ldkuwcc7 51 1 Among among IN cord-287123-ldkuwcc7 51 2 these these DT cord-287123-ldkuwcc7 51 3 genes gene NNS cord-287123-ldkuwcc7 51 4 , , , cord-287123-ldkuwcc7 51 5 mFpr mFpr NNP cord-287123-ldkuwcc7 51 6 - - HYPH cord-287123-ldkuwcc7 51 7 rs5 rs5 NNP cord-287123-ldkuwcc7 51 8 ( ( -LRB- cord-287123-ldkuwcc7 51 9 ψmFpr ψmfpr NN cord-287123-ldkuwcc7 51 10 - - HYPH cord-287123-ldkuwcc7 51 11 rs3 rs3 NNP cord-287123-ldkuwcc7 51 12 ) ) -RRB- cord-287123-ldkuwcc7 51 13 is be VBZ cord-287123-ldkuwcc7 51 14 found find VBN cord-287123-ldkuwcc7 51 15 as as IN cord-287123-ldkuwcc7 51 16 a a DT cord-287123-ldkuwcc7 51 17 pseudogene pseudogene NN cord-287123-ldkuwcc7 51 18 that that WDT cord-287123-ldkuwcc7 51 19 does do VBZ cord-287123-ldkuwcc7 51 20 not not RB cord-287123-ldkuwcc7 51 21 code code VB cord-287123-ldkuwcc7 51 22 for for IN cord-287123-ldkuwcc7 51 23 a a DT cord-287123-ldkuwcc7 51 24 functional functional JJ cord-287123-ldkuwcc7 51 25 receptor receptor NN cord-287123-ldkuwcc7 51 26 . . . cord-287123-ldkuwcc7 52 1 Although although IN cord-287123-ldkuwcc7 52 2 several several JJ cord-287123-ldkuwcc7 52 3 mouse mouse NN cord-287123-ldkuwcc7 52 4 Fpr Fpr NNP cord-287123-ldkuwcc7 52 5 genes gene NNS cord-287123-ldkuwcc7 52 6 are be VBP cord-287123-ldkuwcc7 52 7 present present JJ cord-287123-ldkuwcc7 52 8 in in IN cord-287123-ldkuwcc7 52 9 neutrophils neutrophil NNS cord-287123-ldkuwcc7 52 10 , , , cord-287123-ldkuwcc7 52 11 work work VB cord-287123-ldkuwcc7 52 12 on on IN cord-287123-ldkuwcc7 52 13 mFprs mFprs NNP cord-287123-ldkuwcc7 52 14 has have VBZ cord-287123-ldkuwcc7 52 15 been be VBN cord-287123-ldkuwcc7 52 16 focused focus VBN cord-287123-ldkuwcc7 52 17 mostly mostly RB cord-287123-ldkuwcc7 52 18 on on IN cord-287123-ldkuwcc7 52 19 the the DT cord-287123-ldkuwcc7 52 20 gene gene NN cord-287123-ldkuwcc7 52 21 products product NNS cord-287123-ldkuwcc7 52 22 of of IN cord-287123-ldkuwcc7 52 23 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 52 24 and and CC cord-287123-ldkuwcc7 52 25 mFpr2 mFpr2 NNP cord-287123-ldkuwcc7 52 26 , , , cord-287123-ldkuwcc7 52 27 which which WDT cord-287123-ldkuwcc7 52 28 are be VBP cord-287123-ldkuwcc7 52 29 widely widely RB cord-287123-ldkuwcc7 52 30 expressed express VBN cord-287123-ldkuwcc7 52 31 in in IN cord-287123-ldkuwcc7 52 32 mouse mouse NN cord-287123-ldkuwcc7 52 33 phagocytic phagocytic JJ cord-287123-ldkuwcc7 52 34 leukocytes leukocyte NNS cord-287123-ldkuwcc7 52 35 and and CC cord-287123-ldkuwcc7 52 36 show show VBP cord-287123-ldkuwcc7 52 37 high high JJ cord-287123-ldkuwcc7 52 38 similarity similarity NN cord-287123-ldkuwcc7 52 39 to to IN cord-287123-ldkuwcc7 52 40 their -PRON- PRP$ cord-287123-ldkuwcc7 52 41 human human JJ cord-287123-ldkuwcc7 52 42 counterparts counterpart NNS cord-287123-ldkuwcc7 52 43 . . . cord-287123-ldkuwcc7 53 1 Targeted target VBN cord-287123-ldkuwcc7 53 2 deletion deletion NN cord-287123-ldkuwcc7 53 3 of of IN cord-287123-ldkuwcc7 53 4 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 53 5 or or CC cord-287123-ldkuwcc7 53 6 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 53 7 renders render VBZ cord-287123-ldkuwcc7 53 8 mice mouse NNS cord-287123-ldkuwcc7 53 9 more more RBR cord-287123-ldkuwcc7 53 10 susceptible susceptible JJ cord-287123-ldkuwcc7 53 11 to to IN cord-287123-ldkuwcc7 53 12 bacterial bacterial JJ cord-287123-ldkuwcc7 53 13 infection infection NN cord-287123-ldkuwcc7 53 14 without without IN cord-287123-ldkuwcc7 53 15 changing change VBG cord-287123-ldkuwcc7 53 16 their -PRON- PRP$ cord-287123-ldkuwcc7 53 17 viability viability NN cord-287123-ldkuwcc7 53 18 and and CC cord-287123-ldkuwcc7 53 19 fertility fertility NN cord-287123-ldkuwcc7 53 20 [ [ -LRB- cord-287123-ldkuwcc7 53 21 21 21 CD cord-287123-ldkuwcc7 53 22 , , , cord-287123-ldkuwcc7 53 23 22 22 CD cord-287123-ldkuwcc7 53 24 ] ] -RRB- cord-287123-ldkuwcc7 53 25 . . . cord-287123-ldkuwcc7 54 1 Under under IN cord-287123-ldkuwcc7 54 2 unstimulated unstimulated JJ cord-287123-ldkuwcc7 54 3 conditions condition NNS cord-287123-ldkuwcc7 54 4 , , , cord-287123-ldkuwcc7 54 5 mice mouse NNS cord-287123-ldkuwcc7 54 6 lacking lack VBG cord-287123-ldkuwcc7 54 7 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 54 8 or or CC cord-287123-ldkuwcc7 54 9 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 54 10 behave behave VB cord-287123-ldkuwcc7 54 11 normally normally RB cord-287123-ldkuwcc7 54 12 . . . cord-287123-ldkuwcc7 55 1 However however RB cord-287123-ldkuwcc7 55 2 , , , cord-287123-ldkuwcc7 55 3 in in IN cord-287123-ldkuwcc7 55 4 models model NNS cord-287123-ldkuwcc7 55 5 of of IN cord-287123-ldkuwcc7 55 6 human human JJ cord-287123-ldkuwcc7 55 7 diseases disease NNS cord-287123-ldkuwcc7 55 8 , , , cord-287123-ldkuwcc7 55 9 both both DT cord-287123-ldkuwcc7 55 10 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 55 11 −/− −/− NNP cord-287123-ldkuwcc7 55 12 and and CC cord-287123-ldkuwcc7 55 13 mFpr2 mFpr2 NNP cord-287123-ldkuwcc7 55 14 −/− −/− NNP cord-287123-ldkuwcc7 55 15 mice mouse NNS cord-287123-ldkuwcc7 55 16 respond respond VBP cord-287123-ldkuwcc7 55 17 differently differently RB cord-287123-ldkuwcc7 55 18 from from IN cord-287123-ldkuwcc7 55 19 their -PRON- PRP$ cord-287123-ldkuwcc7 55 20 wildtype wildtype JJ cord-287123-ldkuwcc7 55 21 littermates littermate NNS cord-287123-ldkuwcc7 55 22 , , , cord-287123-ldkuwcc7 55 23 indicating indicate VBG cord-287123-ldkuwcc7 55 24 regulatory regulatory JJ cord-287123-ldkuwcc7 55 25 roles role NNS cord-287123-ldkuwcc7 55 26 of of IN cord-287123-ldkuwcc7 55 27 these these DT cord-287123-ldkuwcc7 55 28 receptors receptor NNS cord-287123-ldkuwcc7 55 29 in in IN cord-287123-ldkuwcc7 55 30 host host NN cord-287123-ldkuwcc7 55 31 defense defense NN cord-287123-ldkuwcc7 55 32 and and CC cord-287123-ldkuwcc7 55 33 inflammation inflammation NN cord-287123-ldkuwcc7 55 34 . . . cord-287123-ldkuwcc7 56 1 Targeted target VBN cord-287123-ldkuwcc7 56 2 gene gene NN cord-287123-ldkuwcc7 56 3 disruption disruption NN cord-287123-ldkuwcc7 56 4 of of IN cord-287123-ldkuwcc7 56 5 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 56 6 also also RB cord-287123-ldkuwcc7 56 7 suggested suggest VBD cord-287123-ldkuwcc7 56 8 a a DT cord-287123-ldkuwcc7 56 9 homeostatic homeostatic JJ cord-287123-ldkuwcc7 56 10 role role NN cord-287123-ldkuwcc7 56 11 for for IN cord-287123-ldkuwcc7 56 12 the the DT cord-287123-ldkuwcc7 56 13 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 56 14 in in IN cord-287123-ldkuwcc7 56 15 the the DT cord-287123-ldkuwcc7 56 16 production production NN cord-287123-ldkuwcc7 56 17 of of IN cord-287123-ldkuwcc7 56 18 glucocorticoids glucocorticoid NNS cord-287123-ldkuwcc7 56 19 and and CC cord-287123-ldkuwcc7 56 20 anxiety anxiety NN cord-287123-ldkuwcc7 56 21 - - HYPH cord-287123-ldkuwcc7 56 22 like like JJ cord-287123-ldkuwcc7 56 23 behavior behavior NN cord-287123-ldkuwcc7 56 24 [ [ -LRB- cord-287123-ldkuwcc7 56 25 23 23 CD cord-287123-ldkuwcc7 56 26 ] ] -RRB- cord-287123-ldkuwcc7 56 27 . . . cord-287123-ldkuwcc7 57 1 As as IN cord-287123-ldkuwcc7 57 2 the the DT cord-287123-ldkuwcc7 57 3 suggested suggest VBN cord-287123-ldkuwcc7 57 4 ortholog ortholog NN cord-287123-ldkuwcc7 57 5 of of IN cord-287123-ldkuwcc7 57 6 human human NNP cord-287123-ldkuwcc7 57 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 57 8 , , , cord-287123-ldkuwcc7 57 9 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 57 10 was be VBD cord-287123-ldkuwcc7 57 11 identified identify VBN cord-287123-ldkuwcc7 57 12 as as IN cord-287123-ldkuwcc7 57 13 a a DT cord-287123-ldkuwcc7 57 14 low low JJ cord-287123-ldkuwcc7 57 15 - - HYPH cord-287123-ldkuwcc7 57 16 affinity affinity NN cord-287123-ldkuwcc7 57 17 receptor receptor NN cord-287123-ldkuwcc7 57 18 for for IN cord-287123-ldkuwcc7 57 19 the the DT cord-287123-ldkuwcc7 57 20 classical classical JJ cord-287123-ldkuwcc7 57 21 formyl formyl NNP cord-287123-ldkuwcc7 57 22 tri tri JJ cord-287123-ldkuwcc7 57 23 - - JJ cord-287123-ldkuwcc7 57 24 peptide peptide JJ cord-287123-ldkuwcc7 57 25 fMet fMet NNP cord-287123-ldkuwcc7 57 26 - - HYPH cord-287123-ldkuwcc7 57 27 Leu Leu NNP cord-287123-ldkuwcc7 57 28 - - HYPH cord-287123-ldkuwcc7 57 29 Phe Phe NNP cord-287123-ldkuwcc7 57 30 ( ( -LRB- cord-287123-ldkuwcc7 57 31 fMLF fmlf NN cord-287123-ldkuwcc7 57 32 ) ) -RRB- cord-287123-ldkuwcc7 57 33 [ [ -LRB- cord-287123-ldkuwcc7 57 34 24 24 CD cord-287123-ldkuwcc7 57 35 ] ] -RRB- cord-287123-ldkuwcc7 57 36 , , , cord-287123-ldkuwcc7 57 37 but but CC cord-287123-ldkuwcc7 57 38 this this DT cord-287123-ldkuwcc7 57 39 receptor receptor NN cord-287123-ldkuwcc7 57 40 responds respond VBZ cord-287123-ldkuwcc7 57 41 well well RB cord-287123-ldkuwcc7 57 42 to to IN cord-287123-ldkuwcc7 57 43 several several JJ cord-287123-ldkuwcc7 57 44 N N NNP cord-287123-ldkuwcc7 57 45 - - HYPH cord-287123-ldkuwcc7 57 46 formyl formyl NNP cord-287123-ldkuwcc7 57 47 peptides peptide NNS cord-287123-ldkuwcc7 57 48 derived derive VBN cord-287123-ldkuwcc7 57 49 from from IN cord-287123-ldkuwcc7 57 50 other other JJ cord-287123-ldkuwcc7 57 51 bacteria bacteria NNS cord-287123-ldkuwcc7 57 52 ( ( -LRB- cord-287123-ldkuwcc7 57 53 e.g. e.g. RB cord-287123-ldkuwcc7 57 54 , , , cord-287123-ldkuwcc7 57 55 fMIFL fMIFL NNP cord-287123-ldkuwcc7 57 56 , , , cord-287123-ldkuwcc7 57 57 fMIVIL fMIVIL NNP cord-287123-ldkuwcc7 57 58 , , , cord-287123-ldkuwcc7 57 59 fMIVTLF fMIVTLF NNP cord-287123-ldkuwcc7 57 60 ) ) -RRB- cord-287123-ldkuwcc7 57 61 and and CC cord-287123-ldkuwcc7 57 62 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 57 63 ( ( -LRB- cord-287123-ldkuwcc7 57 64 e.g. e.g. RB cord-287123-ldkuwcc7 57 65 , , , cord-287123-ldkuwcc7 57 66 fMMYALF fmmyalf NN cord-287123-ldkuwcc7 57 67 ) ) -RRB- cord-287123-ldkuwcc7 57 68 [ [ -LRB- cord-287123-ldkuwcc7 57 69 25 25 CD cord-287123-ldkuwcc7 57 70 , , , cord-287123-ldkuwcc7 57 71 26 26 CD cord-287123-ldkuwcc7 57 72 ] ] -RRB- cord-287123-ldkuwcc7 57 73 . . . cord-287123-ldkuwcc7 58 1 In in IN cord-287123-ldkuwcc7 58 2 general general JJ cord-287123-ldkuwcc7 58 3 , , , cord-287123-ldkuwcc7 58 4 mFpr2 mFpr2 NNP cord-287123-ldkuwcc7 58 5 is be VBZ cord-287123-ldkuwcc7 58 6 not not RB cord-287123-ldkuwcc7 58 7 a a DT cord-287123-ldkuwcc7 58 8 high high JJ cord-287123-ldkuwcc7 58 9 - - HYPH cord-287123-ldkuwcc7 58 10 affinity affinity NN cord-287123-ldkuwcc7 58 11 receptor receptor NN cord-287123-ldkuwcc7 58 12 for for IN cord-287123-ldkuwcc7 58 13 either either DT cord-287123-ldkuwcc7 58 14 fMLF fMLF NNP cord-287123-ldkuwcc7 58 15 or or CC cord-287123-ldkuwcc7 58 16 other other JJ cord-287123-ldkuwcc7 58 17 native native JJ cord-287123-ldkuwcc7 58 18 formyl formyl NNP cord-287123-ldkuwcc7 58 19 peptides peptide NNS cord-287123-ldkuwcc7 58 20 tested test VBN cord-287123-ldkuwcc7 58 21 so so RB cord-287123-ldkuwcc7 58 22 far far RB cord-287123-ldkuwcc7 58 23 [ [ -LRB- cord-287123-ldkuwcc7 58 24 26 26 CD cord-287123-ldkuwcc7 58 25 ] ] -RRB- cord-287123-ldkuwcc7 58 26 . . . cord-287123-ldkuwcc7 59 1 However however RB cord-287123-ldkuwcc7 59 2 , , , cord-287123-ldkuwcc7 59 3 it -PRON- PRP cord-287123-ldkuwcc7 59 4 responds respond VBZ cord-287123-ldkuwcc7 59 5 to to IN cord-287123-ldkuwcc7 59 6 endogenous endogenous JJ cord-287123-ldkuwcc7 59 7 peptide peptide NN cord-287123-ldkuwcc7 59 8 agonists agonist NNS cord-287123-ldkuwcc7 59 9 for for IN cord-287123-ldkuwcc7 59 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 59 11 , , , cord-287123-ldkuwcc7 59 12 including include VBG cord-287123-ldkuwcc7 59 13 the the DT cord-287123-ldkuwcc7 59 14 amyloidogenic amyloidogenic NNP cord-287123-ldkuwcc7 59 15 proteins protein VBZ cord-287123-ldkuwcc7 59 16 SAA SAA NNP cord-287123-ldkuwcc7 59 17 ( ( -LRB- cord-287123-ldkuwcc7 59 18 serum serum NN cord-287123-ldkuwcc7 59 19 amyloid amyloid NN cord-287123-ldkuwcc7 59 20 A A NNP cord-287123-ldkuwcc7 59 21 ) ) -RRB- cord-287123-ldkuwcc7 59 22 [ [ -LRB- cord-287123-ldkuwcc7 59 23 27 27 CD cord-287123-ldkuwcc7 59 24 ] ] -RRB- cord-287123-ldkuwcc7 59 25 and and CC cord-287123-ldkuwcc7 59 26 Aβ Aβ NNP cord-287123-ldkuwcc7 59 27 42 42 CD cord-287123-ldkuwcc7 59 28 [ [ -LRB- cord-287123-ldkuwcc7 59 29 28 28 CD cord-287123-ldkuwcc7 59 30 ] ] -RRB- cord-287123-ldkuwcc7 59 31 . . . cord-287123-ldkuwcc7 60 1 Likewise likewise RB cord-287123-ldkuwcc7 60 2 , , , cord-287123-ldkuwcc7 60 3 this this DT cord-287123-ldkuwcc7 60 4 receptor receptor NN cord-287123-ldkuwcc7 60 5 can can MD cord-287123-ldkuwcc7 60 6 be be VB cord-287123-ldkuwcc7 60 7 inhibited inhibit VBN cord-287123-ldkuwcc7 60 8 by by IN cord-287123-ldkuwcc7 60 9 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 60 10 antagonists antagonist NNS cord-287123-ldkuwcc7 60 11 when when WRB cord-287123-ldkuwcc7 60 12 expressed express VBN cord-287123-ldkuwcc7 60 13 in in IN cord-287123-ldkuwcc7 60 14 neutrophil neutrophil NN cord-287123-ldkuwcc7 60 15 or or CC cord-287123-ldkuwcc7 60 16 by by IN cord-287123-ldkuwcc7 60 17 stably stably RB cord-287123-ldkuwcc7 60 18 transfected transfecte VBN cord-287123-ldkuwcc7 60 19 cells cell NNS cord-287123-ldkuwcc7 60 20 . . . cord-287123-ldkuwcc7 61 1 Besides besides IN cord-287123-ldkuwcc7 61 2 this this DT cord-287123-ldkuwcc7 61 3 , , , cord-287123-ldkuwcc7 61 4 mouse mouse NN cord-287123-ldkuwcc7 61 5 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 61 6 has have VBZ cord-287123-ldkuwcc7 61 7 also also RB cord-287123-ldkuwcc7 61 8 been be VBN cord-287123-ldkuwcc7 61 9 reported report VBN cord-287123-ldkuwcc7 61 10 as as IN cord-287123-ldkuwcc7 61 11 a a DT cord-287123-ldkuwcc7 61 12 receptor receptor NN cord-287123-ldkuwcc7 61 13 for for IN cord-287123-ldkuwcc7 61 14 F2L F2L NNP cord-287123-ldkuwcc7 61 15 [ [ -LRB- cord-287123-ldkuwcc7 61 16 29 29 CD cord-287123-ldkuwcc7 61 17 ] ] -RRB- cord-287123-ldkuwcc7 61 18 that that WDT cord-287123-ldkuwcc7 61 19 is be VBZ cord-287123-ldkuwcc7 61 20 a a DT cord-287123-ldkuwcc7 61 21 potent potent JJ cord-287123-ldkuwcc7 61 22 agonist agonist NN cord-287123-ldkuwcc7 61 23 for for IN cord-287123-ldkuwcc7 61 24 human human JJ cord-287123-ldkuwcc7 61 25 FPR3 FPR3 NNP cord-287123-ldkuwcc7 61 26 [ [ -LRB- cord-287123-ldkuwcc7 61 27 30 30 CD cord-287123-ldkuwcc7 61 28 ] ] -RRB- cord-287123-ldkuwcc7 61 29 . . . cord-287123-ldkuwcc7 62 1 Published publish VBN cord-287123-ldkuwcc7 62 2 reports report NNS cord-287123-ldkuwcc7 62 3 indicate indicate VBP cord-287123-ldkuwcc7 62 4 that that IN cord-287123-ldkuwcc7 62 5 other other JJ cord-287123-ldkuwcc7 62 6 members member NNS cord-287123-ldkuwcc7 62 7 of of IN cord-287123-ldkuwcc7 62 8 the the DT cord-287123-ldkuwcc7 62 9 murine murine JJ cord-287123-ldkuwcc7 62 10 mFpr mFpr NNP cord-287123-ldkuwcc7 62 11 family family NN cord-287123-ldkuwcc7 62 12 are be VBP cord-287123-ldkuwcc7 62 13 not not RB cord-287123-ldkuwcc7 62 14 coding code VBG cord-287123-ldkuwcc7 62 15 for for IN cord-287123-ldkuwcc7 62 16 stereotypic stereotypic JJ cord-287123-ldkuwcc7 62 17 formyl formyl NNP cord-287123-ldkuwcc7 62 18 peptide peptide NN cord-287123-ldkuwcc7 62 19 receptors receptor NNS cord-287123-ldkuwcc7 62 20 . . . cord-287123-ldkuwcc7 63 1 In in IN cord-287123-ldkuwcc7 63 2 recent recent JJ cord-287123-ldkuwcc7 63 3 studies study NNS cord-287123-ldkuwcc7 63 4 , , , cord-287123-ldkuwcc7 63 5 mFpr mfpr JJ cord-287123-ldkuwcc7 63 6 - - HYPH cord-287123-ldkuwcc7 63 7 rs8 rs8 JJ cord-287123-ldkuwcc7 63 8 ( ( -LRB- cord-287123-ldkuwcc7 63 9 ψmFpr ψmfpr NN cord-287123-ldkuwcc7 63 10 - - HYPH cord-287123-ldkuwcc7 63 11 rs2 rs2 NN cord-287123-ldkuwcc7 63 12 ) ) -RRB- cord-287123-ldkuwcc7 63 13 has have VBZ cord-287123-ldkuwcc7 63 14 been be VBN cord-287123-ldkuwcc7 63 15 characterized characterize VBN cord-287123-ldkuwcc7 63 16 as as IN cord-287123-ldkuwcc7 63 17 a a DT cord-287123-ldkuwcc7 63 18 constitutively constitutively RB cord-287123-ldkuwcc7 63 19 expressed express VBN cord-287123-ldkuwcc7 63 20 gene gene NN cord-287123-ldkuwcc7 63 21 associated associate VBN cord-287123-ldkuwcc7 63 22 with with IN cord-287123-ldkuwcc7 63 23 mouse mouse NN cord-287123-ldkuwcc7 63 24 longevity longevity NN cord-287123-ldkuwcc7 63 25 [ [ -LRB- cord-287123-ldkuwcc7 63 26 31 31 CD cord-287123-ldkuwcc7 63 27 ] ] -RRB- cord-287123-ldkuwcc7 63 28 . . . cord-287123-ldkuwcc7 64 1 The the DT cord-287123-ldkuwcc7 64 2 gene gene NN cord-287123-ldkuwcc7 64 3 products product NNS cord-287123-ldkuwcc7 64 4 of of IN cord-287123-ldkuwcc7 64 5 five five CD cord-287123-ldkuwcc7 64 6 other other JJ cord-287123-ldkuwcc7 64 7 mFprs mFprs NNP cord-287123-ldkuwcc7 64 8 , , , cord-287123-ldkuwcc7 64 9 including include VBG cord-287123-ldkuwcc7 64 10 mFpr mFpr NNP cord-287123-ldkuwcc7 64 11 - - HYPH cord-287123-ldkuwcc7 64 12 rs1 rs1 NNP cord-287123-ldkuwcc7 64 13 , , , cord-287123-ldkuwcc7 64 14 mFpr mfpr JJ cord-287123-ldkuwcc7 64 15 - - HYPH cord-287123-ldkuwcc7 64 16 rs3 rs3 JJ cord-287123-ldkuwcc7 64 17 , , , cord-287123-ldkuwcc7 64 18 mFpr mFpr NNP cord-287123-ldkuwcc7 64 19 - - HYPH cord-287123-ldkuwcc7 64 20 rs4 rs4 NNP cord-287123-ldkuwcc7 64 21 , , , cord-287123-ldkuwcc7 64 22 mFpr mFpr NNP cord-287123-ldkuwcc7 64 23 - - HYPH cord-287123-ldkuwcc7 64 24 rs6 rs6 NNP cord-287123-ldkuwcc7 64 25 , , , cord-287123-ldkuwcc7 64 26 and and CC cord-287123-ldkuwcc7 64 27 mFpr mfpr JJ cord-287123-ldkuwcc7 64 28 - - HYPH cord-287123-ldkuwcc7 64 29 rs7 rs7 JJ cord-287123-ldkuwcc7 64 30 , , , cord-287123-ldkuwcc7 64 31 are be VBP cord-287123-ldkuwcc7 64 32 recently recently RB cord-287123-ldkuwcc7 64 33 described describe VBN cord-287123-ldkuwcc7 64 34 as as IN cord-287123-ldkuwcc7 64 35 mouse mouse NN cord-287123-ldkuwcc7 64 36 vomeronasal vomeronasal NN cord-287123-ldkuwcc7 64 37 sensory sensory JJ cord-287123-ldkuwcc7 64 38 receptors receptor NNS cord-287123-ldkuwcc7 64 39 [ [ -LRB- cord-287123-ldkuwcc7 64 40 32 32 CD cord-287123-ldkuwcc7 64 41 , , , cord-287123-ldkuwcc7 64 42 33 33 CD cord-287123-ldkuwcc7 64 43 ] ] -RRB- cord-287123-ldkuwcc7 64 44 . . . cord-287123-ldkuwcc7 65 1 Phylogenetic phylogenetic JJ cord-287123-ldkuwcc7 65 2 analysis analysis NN cord-287123-ldkuwcc7 65 3 suggested suggest VBD cord-287123-ldkuwcc7 65 4 that that IN cord-287123-ldkuwcc7 65 5 they -PRON- PRP cord-287123-ldkuwcc7 65 6 belong belong VBP cord-287123-ldkuwcc7 65 7 to to IN cord-287123-ldkuwcc7 65 8 a a DT cord-287123-ldkuwcc7 65 9 chemosensory chemosensory JJ cord-287123-ldkuwcc7 65 10 GPCR GPCR NNP cord-287123-ldkuwcc7 65 11 family family NN cord-287123-ldkuwcc7 65 12 , , , cord-287123-ldkuwcc7 65 13 which which WDT cord-287123-ldkuwcc7 65 14 is be VBZ cord-287123-ldkuwcc7 65 15 characterized characterize VBN cord-287123-ldkuwcc7 65 16 with with IN cord-287123-ldkuwcc7 65 17 an an DT cord-287123-ldkuwcc7 65 18 olfactory olfactory JJ cord-287123-ldkuwcc7 65 19 function function NN cord-287123-ldkuwcc7 65 20 and and CC cord-287123-ldkuwcc7 65 21 has have VBZ cord-287123-ldkuwcc7 65 22 the the DT cord-287123-ldkuwcc7 65 23 ability ability NN cord-287123-ldkuwcc7 65 24 to to TO cord-287123-ldkuwcc7 65 25 identify identify VB cord-287123-ldkuwcc7 65 26 pathogenic pathogenic JJ cord-287123-ldkuwcc7 65 27 states state NNS cord-287123-ldkuwcc7 65 28 . . . cord-287123-ldkuwcc7 66 1 Among among IN cord-287123-ldkuwcc7 66 2 them -PRON- PRP cord-287123-ldkuwcc7 66 3 , , , cord-287123-ldkuwcc7 66 4 the the DT cord-287123-ldkuwcc7 66 5 property property NN cord-287123-ldkuwcc7 66 6 of of IN cord-287123-ldkuwcc7 66 7 mFpr mFpr NNP cord-287123-ldkuwcc7 66 8 - - HYPH cord-287123-ldkuwcc7 66 9 rs1 rs1 NNP cord-287123-ldkuwcc7 66 10 is be VBZ cord-287123-ldkuwcc7 66 11 still still RB cord-287123-ldkuwcc7 66 12 uncertain uncertain JJ cord-287123-ldkuwcc7 66 13 as as IN cord-287123-ldkuwcc7 66 14 it -PRON- PRP cord-287123-ldkuwcc7 66 15 is be VBZ cord-287123-ldkuwcc7 66 16 also also RB cord-287123-ldkuwcc7 66 17 expressed express VBN cord-287123-ldkuwcc7 66 18 in in IN cord-287123-ldkuwcc7 66 19 neutrophils neutrophil NNS cord-287123-ldkuwcc7 66 20 . . . cord-287123-ldkuwcc7 67 1 It -PRON- PRP cord-287123-ldkuwcc7 67 2 was be VBD cord-287123-ldkuwcc7 67 3 believed believe VBN cord-287123-ldkuwcc7 67 4 that that IN cord-287123-ldkuwcc7 67 5 mFpr mFpr NNP cord-287123-ldkuwcc7 67 6 - - HYPH cord-287123-ldkuwcc7 67 7 rs1 rs1 NN cord-287123-ldkuwcc7 67 8 might may MD cord-287123-ldkuwcc7 67 9 have have VB cord-287123-ldkuwcc7 67 10 some some DT cord-287123-ldkuwcc7 67 11 functional functional JJ cord-287123-ldkuwcc7 67 12 overlap overlap NN cord-287123-ldkuwcc7 67 13 with with IN cord-287123-ldkuwcc7 67 14 human human JJ cord-287123-ldkuwcc7 67 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 67 16 because because IN cord-287123-ldkuwcc7 67 17 a a DT cord-287123-ldkuwcc7 67 18 variant variant NN cord-287123-ldkuwcc7 67 19 of of IN cord-287123-ldkuwcc7 67 20 mFpr mFpr NNP cord-287123-ldkuwcc7 67 21 - - HYPH cord-287123-ldkuwcc7 67 22 rs1 rs1 NNP cord-287123-ldkuwcc7 67 23 was be VBD cord-287123-ldkuwcc7 67 24 reported report VBN cord-287123-ldkuwcc7 67 25 to to TO cord-287123-ldkuwcc7 67 26 encode encode VB cord-287123-ldkuwcc7 67 27 a a DT cord-287123-ldkuwcc7 67 28 mouse mouse NN cord-287123-ldkuwcc7 67 29 receptor receptor NN cord-287123-ldkuwcc7 67 30 for for IN cord-287123-ldkuwcc7 67 31 lipoxin lipoxin NNP cord-287123-ldkuwcc7 67 32 A4 A4 NNP cord-287123-ldkuwcc7 67 33 ( ( -LRB- cord-287123-ldkuwcc7 67 34 LXA4 LXA4 NNP cord-287123-ldkuwcc7 67 35 ) ) -RRB- cord-287123-ldkuwcc7 67 36 [ [ -LRB- cord-287123-ldkuwcc7 67 37 34 34 CD cord-287123-ldkuwcc7 67 38 ] ] -RRB- cord-287123-ldkuwcc7 67 39 , , , cord-287123-ldkuwcc7 67 40 an an DT cord-287123-ldkuwcc7 67 41 eicosanoid eicosanoid JJ cord-287123-ldkuwcc7 67 42 ligand ligand NN cord-287123-ldkuwcc7 67 43 for for IN cord-287123-ldkuwcc7 67 44 FPR2 FPR2 NNP cord-287123-ldkuwcc7 67 45 . . . cord-287123-ldkuwcc7 68 1 However however RB cord-287123-ldkuwcc7 68 2 , , , cord-287123-ldkuwcc7 68 3 functional functional JJ cord-287123-ldkuwcc7 68 4 and and CC cord-287123-ldkuwcc7 68 5 pharmacology pharmacology NN cord-287123-ldkuwcc7 68 6 assays assay NNS cord-287123-ldkuwcc7 68 7 conducted conduct VBN cord-287123-ldkuwcc7 68 8 in in IN cord-287123-ldkuwcc7 68 9 stably stably RB cord-287123-ldkuwcc7 68 10 transfected transfecte VBN cord-287123-ldkuwcc7 68 11 cells cell NNS cord-287123-ldkuwcc7 68 12 suggested suggest VBD cord-287123-ldkuwcc7 68 13 that that IN cord-287123-ldkuwcc7 68 14 mFpr mFpr NNP cord-287123-ldkuwcc7 68 15 - - HYPH cord-287123-ldkuwcc7 68 16 rs1 rs1 NNP cord-287123-ldkuwcc7 68 17 responds respond VBZ cord-287123-ldkuwcc7 68 18 poorly poorly RB cord-287123-ldkuwcc7 68 19 to to IN cord-287123-ldkuwcc7 68 20 most most JJS cord-287123-ldkuwcc7 68 21 agonists agonist NNS cord-287123-ldkuwcc7 68 22 that that WDT cord-287123-ldkuwcc7 68 23 activate activate VBP cord-287123-ldkuwcc7 68 24 human human JJ cord-287123-ldkuwcc7 68 25 and and CC cord-287123-ldkuwcc7 68 26 murine murine JJ cord-287123-ldkuwcc7 68 27 FPR FPR NNP cord-287123-ldkuwcc7 68 28 receptors receptor NNS cord-287123-ldkuwcc7 68 29 [ [ -LRB- cord-287123-ldkuwcc7 68 30 35 35 CD cord-287123-ldkuwcc7 68 31 ] ] -RRB- cord-287123-ldkuwcc7 68 32 . . . cord-287123-ldkuwcc7 69 1 These these DT cord-287123-ldkuwcc7 69 2 observations observation NNS cord-287123-ldkuwcc7 69 3 add add VBP cord-287123-ldkuwcc7 69 4 to to IN cord-287123-ldkuwcc7 69 5 studies study NNS cord-287123-ldkuwcc7 69 6 using use VBG cord-287123-ldkuwcc7 69 7 knockout knockout NN cord-287123-ldkuwcc7 69 8 animal animal NN cord-287123-ldkuwcc7 69 9 models model NNS cord-287123-ldkuwcc7 69 10 and and CC cord-287123-ldkuwcc7 69 11 together together RB cord-287123-ldkuwcc7 69 12 indicate indicate VBP cord-287123-ldkuwcc7 69 13 that that IN cord-287123-ldkuwcc7 69 14 murine murine JJ cord-287123-ldkuwcc7 69 15 Fprs Fprs NNP cord-287123-ldkuwcc7 69 16 ( ( -LRB- cord-287123-ldkuwcc7 69 17 especially especially RB cord-287123-ldkuwcc7 69 18 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 69 19 and and CC cord-287123-ldkuwcc7 69 20 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 69 21 ) ) -RRB- cord-287123-ldkuwcc7 69 22 share share VB cord-287123-ldkuwcc7 69 23 numerous numerous JJ cord-287123-ldkuwcc7 69 24 structural structural JJ cord-287123-ldkuwcc7 69 25 and and CC cord-287123-ldkuwcc7 69 26 pharmacological pharmacological JJ cord-287123-ldkuwcc7 69 27 properties property NNS cord-287123-ldkuwcc7 69 28 with with IN cord-287123-ldkuwcc7 69 29 human human JJ cord-287123-ldkuwcc7 69 30 FPRs fpr NNS cord-287123-ldkuwcc7 69 31 , , , cord-287123-ldkuwcc7 69 32 but but CC cord-287123-ldkuwcc7 69 33 the the DT cord-287123-ldkuwcc7 69 34 evolutionary evolutionary JJ cord-287123-ldkuwcc7 69 35 correlation correlation NN cord-287123-ldkuwcc7 69 36 between between IN cord-287123-ldkuwcc7 69 37 them -PRON- PRP cord-287123-ldkuwcc7 69 38 is be VBZ cord-287123-ldkuwcc7 69 39 by by IN cord-287123-ldkuwcc7 69 40 no no DT cord-287123-ldkuwcc7 69 41 means means NN cord-287123-ldkuwcc7 69 42 linear linear JJ cord-287123-ldkuwcc7 69 43 . . . cord-287123-ldkuwcc7 70 1 The the DT cord-287123-ldkuwcc7 70 2 FPR FPR NNP cord-287123-ldkuwcc7 70 3 family family NN cord-287123-ldkuwcc7 70 4 is be VBZ cord-287123-ldkuwcc7 70 5 well well RB cord-287123-ldkuwcc7 70 6 known know VBN cord-287123-ldkuwcc7 70 7 for for IN cord-287123-ldkuwcc7 70 8 the the DT cord-287123-ldkuwcc7 70 9 structural structural JJ cord-287123-ldkuwcc7 70 10 diversity diversity NN cord-287123-ldkuwcc7 70 11 of of IN cord-287123-ldkuwcc7 70 12 their -PRON- PRP$ cord-287123-ldkuwcc7 70 13 ligands ligand NNS cord-287123-ldkuwcc7 70 14 , , , cord-287123-ldkuwcc7 70 15 including include VBG cord-287123-ldkuwcc7 70 16 a a DT cord-287123-ldkuwcc7 70 17 variety variety NN cord-287123-ldkuwcc7 70 18 of of IN cord-287123-ldkuwcc7 70 19 ligands ligand NNS cord-287123-ldkuwcc7 70 20 with with IN cord-287123-ldkuwcc7 70 21 different different JJ cord-287123-ldkuwcc7 70 22 chemical chemical NN cord-287123-ldkuwcc7 70 23 properties property NNS cord-287123-ldkuwcc7 70 24 and and CC cord-287123-ldkuwcc7 70 25 origins origin NNS cord-287123-ldkuwcc7 70 26 ranging range VBG cord-287123-ldkuwcc7 70 27 from from IN cord-287123-ldkuwcc7 70 28 natural natural JJ cord-287123-ldkuwcc7 70 29 peptides peptide NNS cord-287123-ldkuwcc7 70 30 to to IN cord-287123-ldkuwcc7 70 31 synthetic synthetic JJ cord-287123-ldkuwcc7 70 32 non non JJ cord-287123-ldkuwcc7 70 33 - - JJ cord-287123-ldkuwcc7 70 34 peptide peptide JJ cord-287123-ldkuwcc7 70 35 compounds compound NNS cord-287123-ldkuwcc7 70 36 [ [ -LRB- cord-287123-ldkuwcc7 70 37 2 2 CD cord-287123-ldkuwcc7 70 38 , , , cord-287123-ldkuwcc7 70 39 5 5 CD cord-287123-ldkuwcc7 70 40 ] ] -RRB- cord-287123-ldkuwcc7 71 1 ( ( -LRB- cord-287123-ldkuwcc7 71 2 Table table NN cord-287123-ldkuwcc7 71 3 1 1 CD cord-287123-ldkuwcc7 71 4 ) ) -RRB- cord-287123-ldkuwcc7 71 5 . . . cord-287123-ldkuwcc7 72 1 FPRs FPRs NNP cord-287123-ldkuwcc7 72 2 are be VBP cord-287123-ldkuwcc7 72 3 therefore therefore RB cord-287123-ldkuwcc7 72 4 classified classify VBN cord-287123-ldkuwcc7 72 5 as as IN cord-287123-ldkuwcc7 72 6 a a DT cord-287123-ldkuwcc7 72 7 group group NN cord-287123-ldkuwcc7 72 8 of of IN cord-287123-ldkuwcc7 72 9 pattern pattern NN cord-287123-ldkuwcc7 72 10 recognition recognition NN cord-287123-ldkuwcc7 72 11 receptors receptor NNS cord-287123-ldkuwcc7 72 12 ( ( -LRB- cord-287123-ldkuwcc7 72 13 PRRs PRRs NNP cord-287123-ldkuwcc7 72 14 ) ) -RRB- cord-287123-ldkuwcc7 72 15 that that WDT cord-287123-ldkuwcc7 72 16 recognize recognize VBP cord-287123-ldkuwcc7 72 17 pathogen pathogen NN cord-287123-ldkuwcc7 72 18 - - HYPH cord-287123-ldkuwcc7 72 19 associated associate VBN cord-287123-ldkuwcc7 72 20 molecular molecular JJ cord-287123-ldkuwcc7 72 21 patterns pattern NNS cord-287123-ldkuwcc7 72 22 ( ( -LRB- cord-287123-ldkuwcc7 72 23 PAMPs pamp NNS cord-287123-ldkuwcc7 72 24 ) ) -RRB- cord-287123-ldkuwcc7 72 25 and and CC cord-287123-ldkuwcc7 72 26 damage damage NN cord-287123-ldkuwcc7 72 27 - - HYPH cord-287123-ldkuwcc7 72 28 associated associate VBN cord-287123-ldkuwcc7 72 29 molecular molecular JJ cord-287123-ldkuwcc7 72 30 pattern pattern NN cord-287123-ldkuwcc7 72 31 ( ( -LRB- cord-287123-ldkuwcc7 72 32 DAMPs DAMPs NNP cord-287123-ldkuwcc7 72 33 ) ) -RRB- cord-287123-ldkuwcc7 72 34 [ [ -LRB- cord-287123-ldkuwcc7 72 35 36 36 CD cord-287123-ldkuwcc7 72 36 ] ] -RRB- cord-287123-ldkuwcc7 72 37 [ [ -LRB- cord-287123-ldkuwcc7 72 38 37 37 CD cord-287123-ldkuwcc7 72 39 ] ] -RRB- cord-287123-ldkuwcc7 72 40 [ [ -LRB- cord-287123-ldkuwcc7 72 41 38 38 CD cord-287123-ldkuwcc7 72 42 ] ] -RRB- cord-287123-ldkuwcc7 72 43 . . . cord-287123-ldkuwcc7 73 1 Among among IN cord-287123-ldkuwcc7 73 2 all all PDT cord-287123-ldkuwcc7 73 3 the the DT cord-287123-ldkuwcc7 73 4 ligands ligand NNS cord-287123-ldkuwcc7 73 5 for for IN cord-287123-ldkuwcc7 73 6 the the DT cord-287123-ldkuwcc7 73 7 FPRs FPRs NNPS cord-287123-ldkuwcc7 73 8 , , , cord-287123-ldkuwcc7 73 9 N n CD cord-287123-ldkuwcc7 73 10 - - HYPH cord-287123-ldkuwcc7 73 11 formylated formylate VBN cord-287123-ldkuwcc7 73 12 peptides peptide NNS cord-287123-ldkuwcc7 73 13 , , , cord-287123-ldkuwcc7 73 14 particularly particularly RB cord-287123-ldkuwcc7 73 15 fMLF fMLF NNP cord-287123-ldkuwcc7 73 16 ( ( -LRB- cord-287123-ldkuwcc7 73 17 an an DT cord-287123-ldkuwcc7 73 18 E. E. NNP cord-287123-ldkuwcc7 73 19 coli coli NNS cord-287123-ldkuwcc7 73 20 - - HYPH cord-287123-ldkuwcc7 73 21 derived derive VBN cord-287123-ldkuwcc7 73 22 chemotactic chemotactic JJ cord-287123-ldkuwcc7 73 23 peptide peptide NN cord-287123-ldkuwcc7 73 24 ) ) -RRB- cord-287123-ldkuwcc7 73 25 , , , cord-287123-ldkuwcc7 73 26 are be VBP cord-287123-ldkuwcc7 73 27 most most RBS cord-287123-ldkuwcc7 73 28 often often RB cord-287123-ldkuwcc7 73 29 studied study VBN cord-287123-ldkuwcc7 73 30 . . . cord-287123-ldkuwcc7 74 1 fMLF fMLF NNP cord-287123-ldkuwcc7 74 2 is be VBZ cord-287123-ldkuwcc7 74 3 among among IN cord-287123-ldkuwcc7 74 4 the the DT cord-287123-ldkuwcc7 74 5 first first JJ cord-287123-ldkuwcc7 74 6 characterized characterize VBN cord-287123-ldkuwcc7 74 7 and and CC cord-287123-ldkuwcc7 74 8 also also RB cord-287123-ldkuwcc7 74 9 the the DT cord-287123-ldkuwcc7 74 10 shortest short JJS cord-287123-ldkuwcc7 74 11 formyl formyl NN cord-287123-ldkuwcc7 74 12 peptides peptide NNS cord-287123-ldkuwcc7 74 13 with with IN cord-287123-ldkuwcc7 74 14 full full JJ cord-287123-ldkuwcc7 74 15 agonistic agonistic JJ cord-287123-ldkuwcc7 74 16 activities activity NNS cord-287123-ldkuwcc7 74 17 [ [ -LRB- cord-287123-ldkuwcc7 74 18 39 39 CD cord-287123-ldkuwcc7 74 19 ] ] -RRB- cord-287123-ldkuwcc7 74 20 [ [ -LRB- cord-287123-ldkuwcc7 74 21 40 40 CD cord-287123-ldkuwcc7 74 22 ] ] -RRB- cord-287123-ldkuwcc7 74 23 [ [ -LRB- cord-287123-ldkuwcc7 74 24 41 41 CD cord-287123-ldkuwcc7 74 25 ] ] -RRB- cord-287123-ldkuwcc7 74 26 . . . cord-287123-ldkuwcc7 75 1 These these DT cord-287123-ldkuwcc7 75 2 peptides peptide NNS cord-287123-ldkuwcc7 75 3 are be VBP cord-287123-ldkuwcc7 75 4 initiated initiate VBN cord-287123-ldkuwcc7 75 5 with with IN cord-287123-ldkuwcc7 75 6 N N NNP cord-287123-ldkuwcc7 75 7 - - HYPH cord-287123-ldkuwcc7 75 8 formyl formyl NN cord-287123-ldkuwcc7 75 9 methionine methionine NN cord-287123-ldkuwcc7 75 10 and and CC cord-287123-ldkuwcc7 75 11 are be VBP cord-287123-ldkuwcc7 75 12 generally generally RB cord-287123-ldkuwcc7 75 13 cleavage cleavage JJ cord-287123-ldkuwcc7 75 14 products product NNS cord-287123-ldkuwcc7 75 15 of of IN cord-287123-ldkuwcc7 75 16 bacterial bacterial JJ cord-287123-ldkuwcc7 75 17 and and CC cord-287123-ldkuwcc7 75 18 mitochondrial mitochondrial JJ cord-287123-ldkuwcc7 75 19 proteins protein NNS cord-287123-ldkuwcc7 75 20 . . . cord-287123-ldkuwcc7 76 1 N n CD cord-287123-ldkuwcc7 76 2 - - HYPH cord-287123-ldkuwcc7 76 3 formylated formylate VBN cord-287123-ldkuwcc7 76 4 peptides peptide NNS cord-287123-ldkuwcc7 76 5 constitute constitute VBP cord-287123-ldkuwcc7 76 6 the the DT cord-287123-ldkuwcc7 76 7 most most RBS cord-287123-ldkuwcc7 76 8 commonly commonly RB cord-287123-ldkuwcc7 76 9 studied study VBN cord-287123-ldkuwcc7 76 10 class class NN cord-287123-ldkuwcc7 76 11 of of IN cord-287123-ldkuwcc7 76 12 FPR fpr NN cord-287123-ldkuwcc7 76 13 agonists agonist NNS cord-287123-ldkuwcc7 76 14 that that WDT cord-287123-ldkuwcc7 76 15 trigger trigger VBP cord-287123-ldkuwcc7 76 16 a a DT cord-287123-ldkuwcc7 76 17 variety variety NN cord-287123-ldkuwcc7 76 18 of of IN cord-287123-ldkuwcc7 76 19 biological biological JJ cord-287123-ldkuwcc7 76 20 activities activity NNS cord-287123-ldkuwcc7 76 21 in in IN cord-287123-ldkuwcc7 76 22 myeloid myeloid NN cord-287123-ldkuwcc7 76 23 cells cell NNS cord-287123-ldkuwcc7 76 24 , , , cord-287123-ldkuwcc7 76 25 such such JJ cord-287123-ldkuwcc7 76 26 as as IN cord-287123-ldkuwcc7 76 27 chemokinesis chemokinesis NN cord-287123-ldkuwcc7 76 28 , , , cord-287123-ldkuwcc7 76 29 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 76 30 , , , cord-287123-ldkuwcc7 76 31 calcium calcium NN cord-287123-ldkuwcc7 76 32 flux flux NN cord-287123-ldkuwcc7 76 33 , , , cord-287123-ldkuwcc7 76 34 cytokine cytokine NN cord-287123-ldkuwcc7 76 35 production production NN cord-287123-ldkuwcc7 76 36 and and CC cord-287123-ldkuwcc7 76 37 superoxide superoxide NN cord-287123-ldkuwcc7 76 38 anion anion NN cord-287123-ldkuwcc7 76 39 generation generation NN cord-287123-ldkuwcc7 76 40 . . . cord-287123-ldkuwcc7 77 1 Through through IN cord-287123-ldkuwcc7 77 2 binding bind VBG cord-287123-ldkuwcc7 77 3 with with IN cord-287123-ldkuwcc7 77 4 the the DT cord-287123-ldkuwcc7 77 5 high high JJ cord-287123-ldkuwcc7 77 6 affinity affinity NN cord-287123-ldkuwcc7 77 7 receptor receptor NN cord-287123-ldkuwcc7 77 8 FPR1 FPR1 NNP cord-287123-ldkuwcc7 77 9 , , , cord-287123-ldkuwcc7 77 10 fMLF fMLF NNP cord-287123-ldkuwcc7 77 11 and and CC cord-287123-ldkuwcc7 77 12 other other JJ cord-287123-ldkuwcc7 77 13 N n CD cord-287123-ldkuwcc7 77 14 - - HYPH cord-287123-ldkuwcc7 77 15 formylated formylate VBN cord-287123-ldkuwcc7 77 16 peptides peptide NNS cord-287123-ldkuwcc7 77 17 serve serve VBP cord-287123-ldkuwcc7 77 18 as as IN cord-287123-ldkuwcc7 77 19 potent potent JJ cord-287123-ldkuwcc7 77 20 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 77 21 , , , cord-287123-ldkuwcc7 77 22 which which WDT cord-287123-ldkuwcc7 77 23 also also RB cord-287123-ldkuwcc7 77 24 include include VBP cord-287123-ldkuwcc7 77 25 activated activate VBN cord-287123-ldkuwcc7 77 26 complements complement NNS cord-287123-ldkuwcc7 77 27 ( ( -LRB- cord-287123-ldkuwcc7 77 28 C5a C5a NNS cord-287123-ldkuwcc7 77 29 , , , cord-287123-ldkuwcc7 77 30 C3a C3a NNP cord-287123-ldkuwcc7 77 31 ) ) -RRB- cord-287123-ldkuwcc7 77 32 and and CC cord-287123-ldkuwcc7 77 33 chemokines chemokine NNS cord-287123-ldkuwcc7 77 34 , , , cord-287123-ldkuwcc7 77 35 in in IN cord-287123-ldkuwcc7 77 36 recruiting recruit VBG cord-287123-ldkuwcc7 77 37 and and CC cord-287123-ldkuwcc7 77 38 guiding guide VBG cord-287123-ldkuwcc7 77 39 leukocytes leukocyte NNS cord-287123-ldkuwcc7 77 40 to to IN cord-287123-ldkuwcc7 77 41 the the DT cord-287123-ldkuwcc7 77 42 site site NN cord-287123-ldkuwcc7 77 43 of of IN cord-287123-ldkuwcc7 77 44 bacterial bacterial JJ cord-287123-ldkuwcc7 77 45 infection infection NN cord-287123-ldkuwcc7 77 46 and and CC cord-287123-ldkuwcc7 77 47 to to IN cord-287123-ldkuwcc7 77 48 damaged damage VBN cord-287123-ldkuwcc7 77 49 tissues tissue NNS cord-287123-ldkuwcc7 77 50 . . . cord-287123-ldkuwcc7 78 1 A a DT cord-287123-ldkuwcc7 78 2 wealth wealth NN cord-287123-ldkuwcc7 78 3 of of IN cord-287123-ldkuwcc7 78 4 literatures literature NNS cord-287123-ldkuwcc7 78 5 have have VBP cord-287123-ldkuwcc7 78 6 described describe VBN cord-287123-ldkuwcc7 78 7 the the DT cord-287123-ldkuwcc7 78 8 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 78 9 properties property NNS cord-287123-ldkuwcc7 78 10 of of IN cord-287123-ldkuwcc7 78 11 N N NNP cord-287123-ldkuwcc7 78 12 - - HYPH cord-287123-ldkuwcc7 78 13 formyl formyl NNP cord-287123-ldkuwcc7 78 14 peptides peptide NNS cord-287123-ldkuwcc7 78 15 . . . cord-287123-ldkuwcc7 79 1 As as RB cord-287123-ldkuwcc7 79 2 early early RB cord-287123-ldkuwcc7 79 3 as as IN cord-287123-ldkuwcc7 79 4 30 30 CD cord-287123-ldkuwcc7 79 5 years year NNS cord-287123-ldkuwcc7 79 6 ago ago RB cord-287123-ldkuwcc7 79 7 , , , cord-287123-ldkuwcc7 79 8 right right RB cord-287123-ldkuwcc7 79 9 after after IN cord-287123-ldkuwcc7 79 10 the the DT cord-287123-ldkuwcc7 79 11 discovery discovery NN cord-287123-ldkuwcc7 79 12 of of IN cord-287123-ldkuwcc7 79 13 N N NNP cord-287123-ldkuwcc7 79 14 - - HYPH cord-287123-ldkuwcc7 79 15 formyl formyl NNP cord-287123-ldkuwcc7 79 16 peptides peptide NNS cord-287123-ldkuwcc7 79 17 , , , cord-287123-ldkuwcc7 79 18 studies study NNS cord-287123-ldkuwcc7 79 19 have have VBP cord-287123-ldkuwcc7 79 20 shown show VBN cord-287123-ldkuwcc7 79 21 that that IN cord-287123-ldkuwcc7 79 22 fMLF fmlf NN cord-287123-ldkuwcc7 79 23 was be VBD cord-287123-ldkuwcc7 79 24 involved involve VBN cord-287123-ldkuwcc7 79 25 in in IN cord-287123-ldkuwcc7 79 26 the the DT cord-287123-ldkuwcc7 79 27 pathogenesis pathogenesis NN cord-287123-ldkuwcc7 79 28 of of IN cord-287123-ldkuwcc7 79 29 multiple multiple JJ cord-287123-ldkuwcc7 79 30 inflammatory inflammatory JJ cord-287123-ldkuwcc7 79 31 diseases disease NNS cord-287123-ldkuwcc7 79 32 such such JJ cord-287123-ldkuwcc7 79 33 as as IN cord-287123-ldkuwcc7 79 34 colitis colitis NN cord-287123-ldkuwcc7 79 35 [ [ -LRB- cord-287123-ldkuwcc7 79 36 42 42 CD cord-287123-ldkuwcc7 79 37 ] ] -RRB- cord-287123-ldkuwcc7 79 38 [ [ -LRB- cord-287123-ldkuwcc7 79 39 43 43 CD cord-287123-ldkuwcc7 79 40 ] ] -RRB- cord-287123-ldkuwcc7 79 41 [ [ -LRB- cord-287123-ldkuwcc7 79 42 44 44 CD cord-287123-ldkuwcc7 79 43 ] ] -RRB- cord-287123-ldkuwcc7 79 44 , , , cord-287123-ldkuwcc7 79 45 pouchitis pouchitis NN cord-287123-ldkuwcc7 79 46 , , , cord-287123-ldkuwcc7 79 47 ulcerative ulcerative JJ cord-287123-ldkuwcc7 79 48 colitis colitis NN cord-287123-ldkuwcc7 79 49 and and CC cord-287123-ldkuwcc7 79 50 Crohn Crohn NNP cord-287123-ldkuwcc7 79 51 's 's POS cord-287123-ldkuwcc7 79 52 disease disease NN cord-287123-ldkuwcc7 79 53 [ [ -LRB- cord-287123-ldkuwcc7 79 54 45 45 CD cord-287123-ldkuwcc7 79 55 , , , cord-287123-ldkuwcc7 79 56 46 46 CD cord-287123-ldkuwcc7 79 57 ] ] -RRB- cord-287123-ldkuwcc7 79 58 and and CC cord-287123-ldkuwcc7 79 59 juvenile juvenile JJ cord-287123-ldkuwcc7 79 60 peridotitis peridotitis NN cord-287123-ldkuwcc7 79 61 [ [ -LRB- cord-287123-ldkuwcc7 79 62 47 47 CD cord-287123-ldkuwcc7 79 63 ] ] -RRB- cord-287123-ldkuwcc7 79 64 . . . cord-287123-ldkuwcc7 80 1 Studies study NNS cord-287123-ldkuwcc7 80 2 also also RB cord-287123-ldkuwcc7 80 3 reported report VBD cord-287123-ldkuwcc7 80 4 that that IN cord-287123-ldkuwcc7 80 5 inhalation inhalation NN cord-287123-ldkuwcc7 80 6 or or CC cord-287123-ldkuwcc7 80 7 injection injection NN cord-287123-ldkuwcc7 80 8 of of IN cord-287123-ldkuwcc7 80 9 fMLF fMLF NNP cord-287123-ldkuwcc7 80 10 can can MD cord-287123-ldkuwcc7 80 11 cause cause VB cord-287123-ldkuwcc7 80 12 rapid rapid JJ cord-287123-ldkuwcc7 80 13 neutropenia neutropenia NN cord-287123-ldkuwcc7 80 14 and and CC cord-287123-ldkuwcc7 80 15 bronchial bronchial JJ cord-287123-ldkuwcc7 80 16 inflammation inflammation NN cord-287123-ldkuwcc7 80 17 in in IN cord-287123-ldkuwcc7 80 18 human human JJ cord-287123-ldkuwcc7 80 19 and and CC cord-287123-ldkuwcc7 80 20 other other JJ cord-287123-ldkuwcc7 80 21 mammals mammal NNS cord-287123-ldkuwcc7 80 22 [ [ -LRB- cord-287123-ldkuwcc7 80 23 48 48 CD cord-287123-ldkuwcc7 80 24 ] ] -RRB- cord-287123-ldkuwcc7 81 1 [ [ -LRB- cord-287123-ldkuwcc7 81 2 49 49 CD cord-287123-ldkuwcc7 81 3 ] ] -RRB- cord-287123-ldkuwcc7 81 4 [ [ -LRB- cord-287123-ldkuwcc7 81 5 50 50 CD cord-287123-ldkuwcc7 81 6 ] ] -RRB- cord-287123-ldkuwcc7 81 7 [ [ -LRB- cord-287123-ldkuwcc7 81 8 51 51 CD cord-287123-ldkuwcc7 81 9 ] ] -RRB- cord-287123-ldkuwcc7 81 10 . . . cord-287123-ldkuwcc7 81 11 _SP cord-287123-ldkuwcc7 82 1 [ [ -LRB- cord-287123-ldkuwcc7 82 2 80 80 CD cord-287123-ldkuwcc7 82 3 ] ] -RRB- cord-287123-ldkuwcc7 82 4 f. f. NN cord-287123-ldkuwcc7 82 5 N N NNP cord-287123-ldkuwcc7 82 6 - - HYPH cord-287123-ldkuwcc7 82 7 phenylureas phenylureas NNP cord-287123-ldkuwcc7 82 8 AG-26 AG-26 NNP cord-287123-ldkuwcc7 82 9 [ [ -LRB- cord-287123-ldkuwcc7 82 10 76 76 CD cord-287123-ldkuwcc7 82 11 ] ] -RRB- cord-287123-ldkuwcc7 83 1 FPR2 FPR2 NNP cord-287123-ldkuwcc7 83 2 > > XX cord-287123-ldkuwcc7 84 1 FPR1 FPR1 NNP cord-287123-ldkuwcc7 84 2 [ [ -LRB- cord-287123-ldkuwcc7 84 3 78 78 CD cord-287123-ldkuwcc7 84 4 , , , cord-287123-ldkuwcc7 84 5 79 79 CD cord-287123-ldkuwcc7 84 6 ] ] -RRB- cord-287123-ldkuwcc7 84 7 e. e. NNP cord-287123-ldkuwcc7 84 8 Pyridazin-3(2H)-one Pyridazin-3(2H)-one NNP cord-287123-ldkuwcc7 85 1 derivative derivative JJ cord-287123-ldkuwcc7 85 2 1 1 CD cord-287123-ldkuwcc7 85 3 _SP cord-287123-ldkuwcc7 85 4 [ [ -LRB- cord-287123-ldkuwcc7 85 5 76 76 CD cord-287123-ldkuwcc7 85 6 ] ] -RRB- cord-287123-ldkuwcc7 85 7 _SP cord-287123-ldkuwcc7 85 8 Molecules Molecules NNP cord-287123-ldkuwcc7 85 9 2017 2017 CD cord-287123-ldkuwcc7 85 10 , , , cord-287123-ldkuwcc7 85 11 22 22 CD cord-287123-ldkuwcc7 85 12 , , , cord-287123-ldkuwcc7 85 13 455 455 CD cord-287123-ldkuwcc7 85 14 6 6 CD cord-287123-ldkuwcc7 85 15 of of IN cord-287123-ldkuwcc7 85 16 31 31 CD cord-287123-ldkuwcc7 85 17 [ [ -LRB- cord-287123-ldkuwcc7 85 18 76 76 CD cord-287123-ldkuwcc7 85 19 ] ] -RRB- cord-287123-ldkuwcc7 85 20 _SP cord-287123-ldkuwcc7 85 21 [ [ -LRB- cord-287123-ldkuwcc7 85 22 76 76 CD cord-287123-ldkuwcc7 85 23 ] ] -RRB- cord-287123-ldkuwcc7 86 1 Human Human NNP cord-287123-ldkuwcc7 86 2 FPR2 FPR2 NNP cord-287123-ldkuwcc7 86 3 is be VBZ cord-287123-ldkuwcc7 86 4 a a DT cord-287123-ldkuwcc7 86 5 low low JJ cord-287123-ldkuwcc7 86 6 affinity affinity NN cord-287123-ldkuwcc7 86 7 receptor receptor NN cord-287123-ldkuwcc7 86 8 for for IN cord-287123-ldkuwcc7 86 9 fMLF fmlf NN cord-287123-ldkuwcc7 86 10 and and CC cord-287123-ldkuwcc7 86 11 many many JJ cord-287123-ldkuwcc7 86 12 potent potent JJ cord-287123-ldkuwcc7 86 13 formyl formyl NN cord-287123-ldkuwcc7 86 14 peptide peptide NN cord-287123-ldkuwcc7 86 15 agonists agonist NNS cord-287123-ldkuwcc7 86 16 for for IN cord-287123-ldkuwcc7 86 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 86 18 . . . cord-287123-ldkuwcc7 87 1 However however RB cord-287123-ldkuwcc7 87 2 , , , cord-287123-ldkuwcc7 87 3 FPR2 FPR2 NNP cord-287123-ldkuwcc7 87 4 displays display VBZ cord-287123-ldkuwcc7 87 5 relatively relatively RB cord-287123-ldkuwcc7 87 6 high high JJ cord-287123-ldkuwcc7 87 7 affinity affinity NN cord-287123-ldkuwcc7 87 8 for for IN cord-287123-ldkuwcc7 87 9 N n CD cord-287123-ldkuwcc7 87 10 - - HYPH cord-287123-ldkuwcc7 87 11 formylated formylate VBN cord-287123-ldkuwcc7 87 12 peptides peptide NNS cord-287123-ldkuwcc7 87 13 of of IN cord-287123-ldkuwcc7 87 14 specific specific JJ cord-287123-ldkuwcc7 87 15 composition composition NN cord-287123-ldkuwcc7 87 16 and and CC cord-287123-ldkuwcc7 87 17 longer long JJR cord-287123-ldkuwcc7 87 18 length length NN cord-287123-ldkuwcc7 87 19 . . . cord-287123-ldkuwcc7 88 1 For for IN cord-287123-ldkuwcc7 88 2 instance instance NN cord-287123-ldkuwcc7 88 3 , , , cord-287123-ldkuwcc7 88 4 FPR2 FPR2 NNP cord-287123-ldkuwcc7 88 5 responds respond VBZ cord-287123-ldkuwcc7 88 6 better well RBR cord-287123-ldkuwcc7 88 7 to to IN cord-287123-ldkuwcc7 88 8 peptides peptide NNS cord-287123-ldkuwcc7 88 9 carrying carry VBG cord-287123-ldkuwcc7 88 10 positive positive JJ cord-287123-ldkuwcc7 88 11 charges charge NNS cord-287123-ldkuwcc7 88 12 at at IN cord-287123-ldkuwcc7 88 13 the the DT cord-287123-ldkuwcc7 88 14 C C NNP cord-287123-ldkuwcc7 88 15 - - HYPH cord-287123-ldkuwcc7 88 16 terminus terminus NN cord-287123-ldkuwcc7 88 17 ( ( -LRB- cord-287123-ldkuwcc7 88 18 e.g. e.g. RB cord-287123-ldkuwcc7 88 19 , , , cord-287123-ldkuwcc7 88 20 fMLFK fmlfk JJ cord-287123-ldkuwcc7 88 21 , , , cord-287123-ldkuwcc7 88 22 fMLFIK fmlfik LS cord-287123-ldkuwcc7 88 23 ) ) -RRB- cord-287123-ldkuwcc7 88 24 than than IN cord-287123-ldkuwcc7 88 25 peptides peptide NNS cord-287123-ldkuwcc7 88 26 with with IN cord-287123-ldkuwcc7 88 27 negative negative JJ cord-287123-ldkuwcc7 88 28 charges charge NNS cord-287123-ldkuwcc7 88 29 ( ( -LRB- cord-287123-ldkuwcc7 88 30 e.g. e.g. RB cord-287123-ldkuwcc7 88 31 , , , cord-287123-ldkuwcc7 88 32 fMLFE fMLFE NNP cord-287123-ldkuwcc7 88 33 and and CC cord-287123-ldkuwcc7 88 34 fMLF fMLF NNP cord-287123-ldkuwcc7 88 35 ) ) -RRB- cord-287123-ldkuwcc7 88 36 [ [ -LRB- cord-287123-ldkuwcc7 88 37 96 96 CD cord-287123-ldkuwcc7 88 38 ] ] -RRB- cord-287123-ldkuwcc7 88 39 . . . cord-287123-ldkuwcc7 89 1 Studies study NNS cord-287123-ldkuwcc7 89 2 also also RB cord-287123-ldkuwcc7 89 3 showed show VBD cord-287123-ldkuwcc7 89 4 that that IN cord-287123-ldkuwcc7 89 5 FPR2 FPR2 NNP cord-287123-ldkuwcc7 89 6 responds respond VBZ cord-287123-ldkuwcc7 89 7 well well RB cord-287123-ldkuwcc7 89 8 to to IN cord-287123-ldkuwcc7 89 9 formyl formyl NNP cord-287123-ldkuwcc7 89 10 peptides peptide NNS cord-287123-ldkuwcc7 89 11 of of IN cord-287123-ldkuwcc7 89 12 microbial microbial JJ cord-287123-ldkuwcc7 89 13 origin origin NN cord-287123-ldkuwcc7 89 14 other other JJ cord-287123-ldkuwcc7 89 15 than than IN cord-287123-ldkuwcc7 89 16 E. E. NNP cord-287123-ldkuwcc7 89 17 coli coli NNS cord-287123-ldkuwcc7 89 18 , , , cord-287123-ldkuwcc7 89 19 such such JJ cord-287123-ldkuwcc7 89 20 as as IN cord-287123-ldkuwcc7 89 21 fMIFL fMIFL NNP cord-287123-ldkuwcc7 89 22 ( ( -LRB- cord-287123-ldkuwcc7 89 23 S. S. NNP cord-287123-ldkuwcc7 89 24 aureus aureus NN cord-287123-ldkuwcc7 89 25 ) ) -RRB- cord-287123-ldkuwcc7 90 1 and and CC cord-287123-ldkuwcc7 90 2 fMIVIL fMIVIL NNP cord-287123-ldkuwcc7 90 3 ( ( -LRB- cord-287123-ldkuwcc7 90 4 L. L. NNP cord-287123-ldkuwcc7 90 5 monocytogenes monocytogenes NNP cord-287123-ldkuwcc7 90 6 ) ) -RRB- cord-287123-ldkuwcc7 90 7 in in IN cord-287123-ldkuwcc7 90 8 calcium calcium NN cord-287123-ldkuwcc7 90 9 mobilization mobilization NN cord-287123-ldkuwcc7 90 10 and and CC cord-287123-ldkuwcc7 90 11 cAMP camp NN cord-287123-ldkuwcc7 90 12 release release NN cord-287123-ldkuwcc7 90 13 assays assay NNS cord-287123-ldkuwcc7 90 14 [ [ -LRB- cord-287123-ldkuwcc7 90 15 96 96 CD cord-287123-ldkuwcc7 90 16 ] ] -RRB- cord-287123-ldkuwcc7 90 17 . . . cord-287123-ldkuwcc7 91 1 In in IN cord-287123-ldkuwcc7 91 2 general general JJ cord-287123-ldkuwcc7 91 3 , , , cord-287123-ldkuwcc7 91 4 most most JJS cord-287123-ldkuwcc7 91 5 bacteria bacteria NNS cord-287123-ldkuwcc7 91 6 - - HYPH cord-287123-ldkuwcc7 91 7 derived derive VBN cord-287123-ldkuwcc7 91 8 formyl formyl NN cord-287123-ldkuwcc7 91 9 peptides peptide NNS cord-287123-ldkuwcc7 91 10 are be VBP cord-287123-ldkuwcc7 91 11 more more RBR cord-287123-ldkuwcc7 91 12 potent potent JJ cord-287123-ldkuwcc7 91 13 at at IN cord-287123-ldkuwcc7 91 14 FPR1 FPR1 NNP cord-287123-ldkuwcc7 91 15 than than IN cord-287123-ldkuwcc7 91 16 FPR2 FPR2 NNP cord-287123-ldkuwcc7 91 17 . . . cord-287123-ldkuwcc7 92 1 A a DT cord-287123-ldkuwcc7 92 2 prominent prominent JJ cord-287123-ldkuwcc7 92 3 exception exception NN cord-287123-ldkuwcc7 92 4 is be VBZ cord-287123-ldkuwcc7 92 5 the the DT cord-287123-ldkuwcc7 92 6 recently recently RB cord-287123-ldkuwcc7 92 7 described describe VBN cord-287123-ldkuwcc7 92 8 cytolytic cytolytic JJ cord-287123-ldkuwcc7 92 9 peptides peptide NNS cord-287123-ldkuwcc7 92 10 PSM PSM NNP cord-287123-ldkuwcc7 92 11 ( ( -LRB- cord-287123-ldkuwcc7 92 12 phenol phenol NN cord-287123-ldkuwcc7 92 13 - - HYPH cord-287123-ldkuwcc7 92 14 soluble soluble JJ cord-287123-ldkuwcc7 92 15 modulins modulin NNS cord-287123-ldkuwcc7 92 16 ) ) -RRB- cord-287123-ldkuwcc7 92 17 that that WDT cord-287123-ldkuwcc7 92 18 are be VBP cord-287123-ldkuwcc7 92 19 α α NN cord-287123-ldkuwcc7 92 20 - - HYPH cord-287123-ldkuwcc7 92 21 helical helical JJ cord-287123-ldkuwcc7 92 22 peptides peptide NNS cord-287123-ldkuwcc7 92 23 composed compose VBN cord-287123-ldkuwcc7 92 24 of of IN cord-287123-ldkuwcc7 92 25 20 20 CD cord-287123-ldkuwcc7 92 26 - - SYM cord-287123-ldkuwcc7 92 27 25 25 CD cord-287123-ldkuwcc7 92 28 amino amino NN cord-287123-ldkuwcc7 92 29 acids acid NNS cord-287123-ldkuwcc7 92 30 [ [ -LRB- cord-287123-ldkuwcc7 92 31 97 97 CD cord-287123-ldkuwcc7 92 32 ] ] -RRB- cord-287123-ldkuwcc7 92 33 . . . cord-287123-ldkuwcc7 93 1 Although although IN cord-287123-ldkuwcc7 93 2 they -PRON- PRP cord-287123-ldkuwcc7 93 3 are be VBP cord-287123-ldkuwcc7 93 4 predominantly predominantly RB cord-287123-ldkuwcc7 93 5 secreted secrete VBN cord-287123-ldkuwcc7 93 6 from from IN cord-287123-ldkuwcc7 93 7 community community NN cord-287123-ldkuwcc7 93 8 - - HYPH cord-287123-ldkuwcc7 93 9 associated associate VBN cord-287123-ldkuwcc7 93 10 methicillin methicillin NN cord-287123-ldkuwcc7 93 11 resistant resistant JJ cord-287123-ldkuwcc7 93 12 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 93 13 aureus aureus NN cord-287123-ldkuwcc7 93 14 ( ( -LRB- cord-287123-ldkuwcc7 93 15 CA CA NNP cord-287123-ldkuwcc7 93 16 - - HYPH cord-287123-ldkuwcc7 93 17 MRSA MRSA NNP cord-287123-ldkuwcc7 93 18 ) ) -RRB- cord-287123-ldkuwcc7 93 19 in in IN cord-287123-ldkuwcc7 93 20 formylated formylate VBN cord-287123-ldkuwcc7 93 21 form form NN cord-287123-ldkuwcc7 93 22 , , , cord-287123-ldkuwcc7 93 23 PSMα PSMα NNS cord-287123-ldkuwcc7 93 24 peptides peptide NNS cord-287123-ldkuwcc7 93 25 are be VBP cord-287123-ldkuwcc7 93 26 more more RBR cord-287123-ldkuwcc7 93 27 selective selective JJ cord-287123-ldkuwcc7 93 28 for for IN cord-287123-ldkuwcc7 93 29 FPR2 FPR2 NNP cord-287123-ldkuwcc7 93 30 than than IN cord-287123-ldkuwcc7 93 31 for for IN cord-287123-ldkuwcc7 93 32 FPR1 FPR1 NNP cord-287123-ldkuwcc7 93 33 [ [ -LRB- cord-287123-ldkuwcc7 93 34 98 98 CD cord-287123-ldkuwcc7 93 35 ] ] -RRB- cord-287123-ldkuwcc7 94 1 [ [ -LRB- cord-287123-ldkuwcc7 94 2 99 99 CD cord-287123-ldkuwcc7 94 3 ] ] -RRB- cord-287123-ldkuwcc7 94 4 [ [ -LRB- cord-287123-ldkuwcc7 94 5 100 100 CD cord-287123-ldkuwcc7 94 6 ] ] -RRB- cord-287123-ldkuwcc7 94 7 . . . cord-287123-ldkuwcc7 95 1 Another another DT cord-287123-ldkuwcc7 95 2 exception exception NN cord-287123-ldkuwcc7 95 3 is be VBZ cord-287123-ldkuwcc7 95 4 mitocryptide-2 mitocryptide-2 NNP cord-287123-ldkuwcc7 95 5 , , , cord-287123-ldkuwcc7 95 6 a a DT cord-287123-ldkuwcc7 95 7 neutrophil neutrophil NN cord-287123-ldkuwcc7 95 8 - - HYPH cord-287123-ldkuwcc7 95 9 activating activate VBG cord-287123-ldkuwcc7 95 10 formyl formyl NNP cord-287123-ldkuwcc7 95 11 peptide peptide NN cord-287123-ldkuwcc7 95 12 produced produce VBN cord-287123-ldkuwcc7 95 13 from from IN cord-287123-ldkuwcc7 95 14 mitochondrial mitochondrial JJ cord-287123-ldkuwcc7 95 15 cytochromes cytochrome NNS cord-287123-ldkuwcc7 95 16 . . . cord-287123-ldkuwcc7 96 1 Mitocryptide-2 Mitocryptide-2 NNP cord-287123-ldkuwcc7 96 2 can can MD cord-287123-ldkuwcc7 96 3 directly directly RB cord-287123-ldkuwcc7 96 4 bind bind VB cord-287123-ldkuwcc7 96 5 to to IN cord-287123-ldkuwcc7 96 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 96 7 and and CC cord-287123-ldkuwcc7 96 8 activate activate VB cord-287123-ldkuwcc7 96 9 it -PRON- PRP cord-287123-ldkuwcc7 96 10 with with IN cord-287123-ldkuwcc7 96 11 an an DT cord-287123-ldkuwcc7 96 12 EC EC NNP cord-287123-ldkuwcc7 96 13 50 50 CD cord-287123-ldkuwcc7 96 14 of of IN cord-287123-ldkuwcc7 96 15 6.9 6.9 CD cord-287123-ldkuwcc7 96 16 nM nm NN cord-287123-ldkuwcc7 96 17 in in IN cord-287123-ldkuwcc7 96 18 calcium calcium NN cord-287123-ldkuwcc7 96 19 flux flux NN cord-287123-ldkuwcc7 96 20 assay assay NN cord-287123-ldkuwcc7 96 21 , , , cord-287123-ldkuwcc7 96 22 whereas whereas IN cord-287123-ldkuwcc7 96 23 it -PRON- PRP cord-287123-ldkuwcc7 96 24 manifests manifest VBZ cord-287123-ldkuwcc7 96 25 no no DT cord-287123-ldkuwcc7 96 26 interaction interaction NN cord-287123-ldkuwcc7 96 27 with with IN cord-287123-ldkuwcc7 96 28 FPR1 FPR1 NNP cord-287123-ldkuwcc7 96 29 [ [ -LRB- cord-287123-ldkuwcc7 96 30 54 54 CD cord-287123-ldkuwcc7 96 31 ] ] -RRB- cord-287123-ldkuwcc7 96 32 . . . cord-287123-ldkuwcc7 97 1 In in IN cord-287123-ldkuwcc7 97 2 addition addition NN cord-287123-ldkuwcc7 97 3 , , , cord-287123-ldkuwcc7 97 4 another another DT cord-287123-ldkuwcc7 97 5 group group NN cord-287123-ldkuwcc7 97 6 of of IN cord-287123-ldkuwcc7 97 7 formyl formyl NNP cord-287123-ldkuwcc7 97 8 peptides peptide NNS cord-287123-ldkuwcc7 97 9 derived derive VBN cord-287123-ldkuwcc7 97 10 from from IN cord-287123-ldkuwcc7 97 11 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 97 12 ( ( -LRB- cord-287123-ldkuwcc7 97 13 fMMYALF fMMYALF NNP cord-287123-ldkuwcc7 97 14 , , , cord-287123-ldkuwcc7 97 15 fMYFINILTL fmyfiniltl NN cord-287123-ldkuwcc7 97 16 , , , cord-287123-ldkuwcc7 97 17 and and CC cord-287123-ldkuwcc7 97 18 fMLKLIV fMLKLIV NNP cord-287123-ldkuwcc7 97 19 ) ) -RRB- cord-287123-ldkuwcc7 97 20 were be VBD cord-287123-ldkuwcc7 97 21 found find VBN cord-287123-ldkuwcc7 97 22 equally equally RB cord-287123-ldkuwcc7 97 23 potent potent JJ cord-287123-ldkuwcc7 97 24 on on IN cord-287123-ldkuwcc7 97 25 FPR1 FPR1 NNP cord-287123-ldkuwcc7 97 26 and and CC cord-287123-ldkuwcc7 97 27 FPR2 FPR2 NNP cord-287123-ldkuwcc7 97 28 with with IN cord-287123-ldkuwcc7 97 29 EC EC NNP cord-287123-ldkuwcc7 97 30 50 50 CD cord-287123-ldkuwcc7 97 31 values value NNS cord-287123-ldkuwcc7 97 32 ranging range VBG cord-287123-ldkuwcc7 97 33 from from IN cord-287123-ldkuwcc7 97 34 10 10 CD cord-287123-ldkuwcc7 97 35 nM nm NN cord-287123-ldkuwcc7 97 36 to to IN cord-287123-ldkuwcc7 97 37 160 160 CD cord-287123-ldkuwcc7 97 38 nM nm CD cord-287123-ldkuwcc7 97 39 [ [ -LRB- cord-287123-ldkuwcc7 97 40 53 53 CD cord-287123-ldkuwcc7 97 41 ] ] -RRB- cord-287123-ldkuwcc7 97 42 . . . cord-287123-ldkuwcc7 98 1 Despite despite IN cord-287123-ldkuwcc7 98 2 the the DT cord-287123-ldkuwcc7 98 3 different different JJ cord-287123-ldkuwcc7 98 4 potency potency NN cord-287123-ldkuwcc7 98 5 and and CC cord-287123-ldkuwcc7 98 6 selectivity selectivity NN cord-287123-ldkuwcc7 98 7 of of IN cord-287123-ldkuwcc7 98 8 these these DT cord-287123-ldkuwcc7 98 9 formyl formyl NNP cord-287123-ldkuwcc7 98 10 peptides peptide NNS cord-287123-ldkuwcc7 98 11 , , , cord-287123-ldkuwcc7 98 12 the the DT cord-287123-ldkuwcc7 98 13 N N NNP cord-287123-ldkuwcc7 98 14 - - HYPH cord-287123-ldkuwcc7 98 15 formyl formyl NNP cord-287123-ldkuwcc7 98 16 group group NN cord-287123-ldkuwcc7 98 17 is be VBZ cord-287123-ldkuwcc7 98 18 important important JJ cord-287123-ldkuwcc7 98 19 for for IN cord-287123-ldkuwcc7 98 20 optimal optimal JJ cord-287123-ldkuwcc7 98 21 interaction interaction NN cord-287123-ldkuwcc7 98 22 with with IN cord-287123-ldkuwcc7 98 23 FPR1 FPR1 NNP cord-287123-ldkuwcc7 98 24 and and CC cord-287123-ldkuwcc7 98 25 FPR2 FPR2 NNP cord-287123-ldkuwcc7 98 26 . . . cord-287123-ldkuwcc7 99 1 It -PRON- PRP cord-287123-ldkuwcc7 99 2 is be VBZ cord-287123-ldkuwcc7 99 3 suggested suggest VBN cord-287123-ldkuwcc7 99 4 that that IN cord-287123-ldkuwcc7 99 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 99 6 is be VBZ cord-287123-ldkuwcc7 99 7 a a DT cord-287123-ldkuwcc7 99 8 highly highly RB cord-287123-ldkuwcc7 99 9 effective effective JJ cord-287123-ldkuwcc7 99 10 receptor receptor NN cord-287123-ldkuwcc7 99 11 recognizing recognize VBG cord-287123-ldkuwcc7 99 12 formyl formyl NNP cord-287123-ldkuwcc7 99 13 peptides peptide NNS cord-287123-ldkuwcc7 99 14 and and CC cord-287123-ldkuwcc7 99 15 mediating mediate VBG cord-287123-ldkuwcc7 99 16 phagocyte phagocyte NNP cord-287123-ldkuwcc7 99 17 functions function NNS cord-287123-ldkuwcc7 99 18 , , , cord-287123-ldkuwcc7 99 19 while while IN cord-287123-ldkuwcc7 99 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 99 21 has have VBZ cord-287123-ldkuwcc7 99 22 an an DT cord-287123-ldkuwcc7 99 23 overall overall JJ cord-287123-ldkuwcc7 99 24 lower low JJR cord-287123-ldkuwcc7 99 25 affinity affinity NN cord-287123-ldkuwcc7 99 26 but but CC cord-287123-ldkuwcc7 99 27 it -PRON- PRP cord-287123-ldkuwcc7 99 28 can can MD cord-287123-ldkuwcc7 99 29 discriminate discriminate VB cord-287123-ldkuwcc7 99 30 between between IN cord-287123-ldkuwcc7 99 31 formyl formyl NNP cord-287123-ldkuwcc7 99 32 peptides peptide NNS cord-287123-ldkuwcc7 99 33 with with IN cord-287123-ldkuwcc7 99 34 different different JJ cord-287123-ldkuwcc7 99 35 sizes size NNS cord-287123-ldkuwcc7 99 36 and and CC cord-287123-ldkuwcc7 99 37 features feature NNS cord-287123-ldkuwcc7 99 38 . . . cord-287123-ldkuwcc7 100 1 In in IN cord-287123-ldkuwcc7 100 2 contrast contrast NN cord-287123-ldkuwcc7 100 3 , , , cord-287123-ldkuwcc7 100 4 no no DT cord-287123-ldkuwcc7 100 5 bacterial bacterial JJ cord-287123-ldkuwcc7 100 6 or or CC cord-287123-ldkuwcc7 100 7 mitochondrial mitochondrial JJ cord-287123-ldkuwcc7 100 8 formyl formyl NNP cord-287123-ldkuwcc7 100 9 peptide peptide NN cord-287123-ldkuwcc7 100 10 has have VBZ cord-287123-ldkuwcc7 100 11 been be VBN cord-287123-ldkuwcc7 100 12 described describe VBN cord-287123-ldkuwcc7 100 13 as as IN cord-287123-ldkuwcc7 100 14 agonist agonist NN cord-287123-ldkuwcc7 100 15 for for IN cord-287123-ldkuwcc7 100 16 FPR3 FPR3 NNP cord-287123-ldkuwcc7 100 17 by by IN cord-287123-ldkuwcc7 100 18 far far RB cord-287123-ldkuwcc7 100 19 . . . cord-287123-ldkuwcc7 101 1 Noting note VBG cord-287123-ldkuwcc7 101 2 that that IN cord-287123-ldkuwcc7 101 3 the the DT cord-287123-ldkuwcc7 101 4 prototypic prototypic NNP cord-287123-ldkuwcc7 101 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 101 6 agonist agonist NN cord-287123-ldkuwcc7 101 7 fMLF fMLF NNP cord-287123-ldkuwcc7 101 8 is be VBZ cord-287123-ldkuwcc7 101 9 not not RB cord-287123-ldkuwcc7 101 10 a a DT cord-287123-ldkuwcc7 101 11 potent potent JJ cord-287123-ldkuwcc7 101 12 activator activator NN cord-287123-ldkuwcc7 101 13 for for IN cord-287123-ldkuwcc7 101 14 murine murine JJ cord-287123-ldkuwcc7 101 15 Fprs Fprs NNP cord-287123-ldkuwcc7 101 16 , , , cord-287123-ldkuwcc7 101 17 including include VBG cord-287123-ldkuwcc7 101 18 mFpr1 mfpr1 NN cord-287123-ldkuwcc7 101 19 and and CC cord-287123-ldkuwcc7 101 20 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 101 21 , , , cord-287123-ldkuwcc7 101 22 when when WRB cord-287123-ldkuwcc7 101 23 compared compare VBN cord-287123-ldkuwcc7 101 24 to to IN cord-287123-ldkuwcc7 101 25 human human JJ cord-287123-ldkuwcc7 101 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 101 27 . . . cord-287123-ldkuwcc7 102 1 In in IN cord-287123-ldkuwcc7 102 2 agreement agreement NN cord-287123-ldkuwcc7 102 3 with with IN cord-287123-ldkuwcc7 102 4 the the DT cord-287123-ldkuwcc7 102 5 research research NN cord-287123-ldkuwcc7 102 6 that that IN cord-287123-ldkuwcc7 102 7 murine murine JJ cord-287123-ldkuwcc7 102 8 neutrophils neutrophil NNS cord-287123-ldkuwcc7 102 9 are be VBP cord-287123-ldkuwcc7 102 10 more more RBR cord-287123-ldkuwcc7 102 11 susceptible susceptible JJ cord-287123-ldkuwcc7 102 12 to to IN cord-287123-ldkuwcc7 102 13 bacteria bacteria NNS cord-287123-ldkuwcc7 102 14 other other JJ cord-287123-ldkuwcc7 102 15 than than IN cord-287123-ldkuwcc7 102 16 E. E. NNP cord-287123-ldkuwcc7 102 17 coli coli NNS cord-287123-ldkuwcc7 102 18 [ [ -LRB- cord-287123-ldkuwcc7 102 19 21 21 CD cord-287123-ldkuwcc7 102 20 ] ] -RRB- cord-287123-ldkuwcc7 102 21 , , , cord-287123-ldkuwcc7 102 22 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 102 23 was be VBD cord-287123-ldkuwcc7 102 24 found find VBN cord-287123-ldkuwcc7 102 25 more more RBR cord-287123-ldkuwcc7 102 26 responsive responsive JJ cord-287123-ldkuwcc7 102 27 to to IN cord-287123-ldkuwcc7 102 28 formyl formyl NNP cord-287123-ldkuwcc7 102 29 peptides peptide NNS cord-287123-ldkuwcc7 102 30 derived derive VBN cord-287123-ldkuwcc7 102 31 from from IN cord-287123-ldkuwcc7 102 32 Listeria Listeria NNP cord-287123-ldkuwcc7 102 33 monocytogenes monocytogene NNS cord-287123-ldkuwcc7 102 34 ( ( -LRB- cord-287123-ldkuwcc7 102 35 fMIVTLF fMIVTLF NNP cord-287123-ldkuwcc7 102 36 ) ) -RRB- cord-287123-ldkuwcc7 102 37 , , , cord-287123-ldkuwcc7 102 38 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 102 39 aureus aureus NN cord-287123-ldkuwcc7 102 40 ( ( -LRB- cord-287123-ldkuwcc7 102 41 fMIFL fMIFL NNP cord-287123-ldkuwcc7 102 42 ) ) -RRB- cord-287123-ldkuwcc7 102 43 , , , cord-287123-ldkuwcc7 102 44 and and CC cord-287123-ldkuwcc7 102 45 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 102 46 ( ( -LRB- cord-287123-ldkuwcc7 102 47 fMMYALF fmmyalf NN cord-287123-ldkuwcc7 102 48 ) ) -RRB- cord-287123-ldkuwcc7 102 49 [ [ -LRB- cord-287123-ldkuwcc7 102 50 25 25 CD cord-287123-ldkuwcc7 102 51 , , , cord-287123-ldkuwcc7 102 52 26 26 CD cord-287123-ldkuwcc7 102 53 ] ] -RRB- cord-287123-ldkuwcc7 102 54 . . . cord-287123-ldkuwcc7 103 1 Except except IN cord-287123-ldkuwcc7 103 2 for for IN cord-287123-ldkuwcc7 103 3 formyl formyl NNP cord-287123-ldkuwcc7 103 4 peptides peptide NNS cord-287123-ldkuwcc7 103 5 , , , cord-287123-ldkuwcc7 103 6 a a DT cord-287123-ldkuwcc7 103 7 number number NN cord-287123-ldkuwcc7 103 8 of of IN cord-287123-ldkuwcc7 103 9 different different JJ cord-287123-ldkuwcc7 103 10 peptides peptide NNS cord-287123-ldkuwcc7 103 11 / / SYM cord-287123-ldkuwcc7 103 12 proteins protein NNS cord-287123-ldkuwcc7 103 13 , , , cord-287123-ldkuwcc7 103 14 including include VBG cord-287123-ldkuwcc7 103 15 microbial microbial NN cord-287123-ldkuwcc7 103 16 and and CC cord-287123-ldkuwcc7 103 17 host host NN cord-287123-ldkuwcc7 103 18 - - HYPH cord-287123-ldkuwcc7 103 19 derived derive VBN cord-287123-ldkuwcc7 103 20 non non JJ cord-287123-ldkuwcc7 103 21 - - JJ cord-287123-ldkuwcc7 103 22 formyl formyl JJ cord-287123-ldkuwcc7 103 23 peptides peptide NNS cord-287123-ldkuwcc7 103 24 / / SYM cord-287123-ldkuwcc7 103 25 proteins protein NNS cord-287123-ldkuwcc7 103 26 and and CC cord-287123-ldkuwcc7 103 27 peptides peptide NNS cord-287123-ldkuwcc7 103 28 from from IN cord-287123-ldkuwcc7 103 29 synthetic synthetic JJ cord-287123-ldkuwcc7 103 30 libraries library NNS cord-287123-ldkuwcc7 103 31 , , , cord-287123-ldkuwcc7 103 32 have have VBP cord-287123-ldkuwcc7 103 33 been be VBN cord-287123-ldkuwcc7 103 34 identified identify VBN cord-287123-ldkuwcc7 103 35 to to TO cord-287123-ldkuwcc7 103 36 be be VB cord-287123-ldkuwcc7 103 37 agonists agonist NNS cord-287123-ldkuwcc7 103 38 for for IN cord-287123-ldkuwcc7 103 39 FPRs fpr NNS cord-287123-ldkuwcc7 103 40 . . . cord-287123-ldkuwcc7 104 1 It -PRON- PRP cord-287123-ldkuwcc7 104 2 appears appear VBZ cord-287123-ldkuwcc7 104 3 that that IN cord-287123-ldkuwcc7 104 4 the the DT cord-287123-ldkuwcc7 104 5 absence absence NN cord-287123-ldkuwcc7 104 6 of of IN cord-287123-ldkuwcc7 104 7 N N NNP cord-287123-ldkuwcc7 104 8 - - HYPH cord-287123-ldkuwcc7 104 9 formyl formyl NNP cord-287123-ldkuwcc7 104 10 group group NN cord-287123-ldkuwcc7 104 11 and and CC cord-287123-ldkuwcc7 104 12 lack lack NN cord-287123-ldkuwcc7 104 13 of of IN cord-287123-ldkuwcc7 104 14 overall overall JJ cord-287123-ldkuwcc7 104 15 sequence sequence NN cord-287123-ldkuwcc7 104 16 similarity similarity NN cord-287123-ldkuwcc7 104 17 with with IN cord-287123-ldkuwcc7 104 18 formyl formyl NNP cord-287123-ldkuwcc7 104 19 peptides peptide NNS cord-287123-ldkuwcc7 104 20 mentioned mention VBN cord-287123-ldkuwcc7 104 21 above above RB cord-287123-ldkuwcc7 104 22 do do VBP cord-287123-ldkuwcc7 104 23 not not RB cord-287123-ldkuwcc7 104 24 impair impair VB cord-287123-ldkuwcc7 104 25 their -PRON- PRP$ cord-287123-ldkuwcc7 104 26 agonistic agonistic JJ cord-287123-ldkuwcc7 104 27 activity activity NN cord-287123-ldkuwcc7 104 28 at at IN cord-287123-ldkuwcc7 104 29 FPRs fpr NNS cord-287123-ldkuwcc7 104 30 . . . cord-287123-ldkuwcc7 105 1 In in IN cord-287123-ldkuwcc7 105 2 general general JJ cord-287123-ldkuwcc7 105 3 , , , cord-287123-ldkuwcc7 105 4 the the DT cord-287123-ldkuwcc7 105 5 ligand ligand NN cord-287123-ldkuwcc7 105 6 diversity diversity NN cord-287123-ldkuwcc7 105 7 is be VBZ cord-287123-ldkuwcc7 105 8 more more RBR cord-287123-ldkuwcc7 105 9 prominent prominent JJ cord-287123-ldkuwcc7 105 10 for for IN cord-287123-ldkuwcc7 105 11 FPR2 FPR2 NNP cord-287123-ldkuwcc7 105 12 than than IN cord-287123-ldkuwcc7 105 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 105 14 . . . cord-287123-ldkuwcc7 106 1 The the DT cord-287123-ldkuwcc7 106 2 non non JJ cord-287123-ldkuwcc7 106 3 - - JJ cord-287123-ldkuwcc7 106 4 formylated formylated JJ cord-287123-ldkuwcc7 106 5 peptides peptide NNS cord-287123-ldkuwcc7 106 6 / / SYM cord-287123-ldkuwcc7 106 7 proteins protein NNS cord-287123-ldkuwcc7 106 8 derived derive VBN cord-287123-ldkuwcc7 106 9 from from IN cord-287123-ldkuwcc7 106 10 microbe microbe NN cord-287123-ldkuwcc7 106 11 are be VBP cord-287123-ldkuwcc7 106 12 represented represent VBN cord-287123-ldkuwcc7 106 13 by by IN cord-287123-ldkuwcc7 106 14 virus virus NN cord-287123-ldkuwcc7 106 15 envelope envelope NN cord-287123-ldkuwcc7 106 16 proteins protein NNS cord-287123-ldkuwcc7 106 17 ( ( -LRB- cord-287123-ldkuwcc7 106 18 gp41 gp41 NN cord-287123-ldkuwcc7 106 19 and and CC cord-287123-ldkuwcc7 106 20 gp120 gp120 NNP cord-287123-ldkuwcc7 106 21 ) ) -RRB- cord-287123-ldkuwcc7 106 22 of of IN cord-287123-ldkuwcc7 106 23 the the DT cord-287123-ldkuwcc7 106 24 human human JJ cord-287123-ldkuwcc7 106 25 immunodeficiency immunodeficiency NN cord-287123-ldkuwcc7 106 26 virus virus NN cord-287123-ldkuwcc7 106 27 type type NN cord-287123-ldkuwcc7 106 28 1 1 CD cord-287123-ldkuwcc7 106 29 ( ( -LRB- cord-287123-ldkuwcc7 106 30 HIV-1 HIV-1 NNP cord-287123-ldkuwcc7 106 31 ) ) -RRB- cord-287123-ldkuwcc7 106 32 , , , cord-287123-ldkuwcc7 106 33 which which WDT cord-287123-ldkuwcc7 106 34 contains contain VBZ cord-287123-ldkuwcc7 106 35 at at IN cord-287123-ldkuwcc7 106 36 least least JJS cord-287123-ldkuwcc7 106 37 five five CD cord-287123-ldkuwcc7 106 38 FPR fpr NN cord-287123-ldkuwcc7 106 39 - - HYPH cord-287123-ldkuwcc7 106 40 recognizing recognize VBG cord-287123-ldkuwcc7 106 41 peptide peptide NN cord-287123-ldkuwcc7 106 42 sequences sequence NNS cord-287123-ldkuwcc7 106 43 composed compose VBN cord-287123-ldkuwcc7 106 44 of of IN cord-287123-ldkuwcc7 106 45 20 20 CD cord-287123-ldkuwcc7 106 46 - - SYM cord-287123-ldkuwcc7 106 47 37 37 CD cord-287123-ldkuwcc7 106 48 amino amino JJ cord-287123-ldkuwcc7 106 49 acids acid NNS cord-287123-ldkuwcc7 106 50 . . . cord-287123-ldkuwcc7 107 1 Most Most JJS cord-287123-ldkuwcc7 107 2 of of IN cord-287123-ldkuwcc7 107 3 these these DT cord-287123-ldkuwcc7 107 4 sequences sequence NNS cord-287123-ldkuwcc7 107 5 were be VBD cord-287123-ldkuwcc7 107 6 found find VBN cord-287123-ldkuwcc7 107 7 more more RBR cord-287123-ldkuwcc7 107 8 potent potent JJ cord-287123-ldkuwcc7 107 9 at at IN cord-287123-ldkuwcc7 107 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 107 11 than than IN cord-287123-ldkuwcc7 107 12 at at IN cord-287123-ldkuwcc7 107 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 107 14 and and CC cord-287123-ldkuwcc7 107 15 FPR3 FPR3 NNP cord-287123-ldkuwcc7 107 16 [ [ -LRB- cord-287123-ldkuwcc7 107 17 101 101 CD cord-287123-ldkuwcc7 107 18 ] ] -RRB- cord-287123-ldkuwcc7 107 19 [ [ -LRB- cord-287123-ldkuwcc7 107 20 102 102 CD cord-287123-ldkuwcc7 107 21 ] ] -RRB- cord-287123-ldkuwcc7 107 22 [ [ -LRB- cord-287123-ldkuwcc7 107 23 103 103 CD cord-287123-ldkuwcc7 107 24 ] ] -RRB- cord-287123-ldkuwcc7 107 25 [ [ -LRB- cord-287123-ldkuwcc7 107 26 104 104 CD cord-287123-ldkuwcc7 107 27 ] ] -RRB- cord-287123-ldkuwcc7 108 1 [ [ -LRB- cord-287123-ldkuwcc7 108 2 105 105 CD cord-287123-ldkuwcc7 108 3 ] ] -RRB- cord-287123-ldkuwcc7 108 4 , , , cord-287123-ldkuwcc7 108 5 except except IN cord-287123-ldkuwcc7 108 6 only only RB cord-287123-ldkuwcc7 108 7 one one CD cord-287123-ldkuwcc7 108 8 is be VBZ cord-287123-ldkuwcc7 108 9 selective selective JJ cord-287123-ldkuwcc7 108 10 for for IN cord-287123-ldkuwcc7 108 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 108 12 and and CC cord-287123-ldkuwcc7 108 13 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 108 14 [ [ -LRB- cord-287123-ldkuwcc7 108 15 101 101 CD cord-287123-ldkuwcc7 108 16 , , , cord-287123-ldkuwcc7 108 17 102 102 CD cord-287123-ldkuwcc7 108 18 , , , cord-287123-ldkuwcc7 108 19 106 106 CD cord-287123-ldkuwcc7 108 20 ] ] -RRB- cord-287123-ldkuwcc7 108 21 . . . cord-287123-ldkuwcc7 109 1 A a DT cord-287123-ldkuwcc7 109 2 cecropin cecropin NN cord-287123-ldkuwcc7 109 3 - - HYPH cord-287123-ldkuwcc7 109 4 like like JJ cord-287123-ldkuwcc7 109 5 peptide peptide NN cord-287123-ldkuwcc7 109 6 ( ( -LRB- cord-287123-ldkuwcc7 109 7 Hp2 hp2 CD cord-287123-ldkuwcc7 109 8 - - SYM cord-287123-ldkuwcc7 109 9 20 20 CD cord-287123-ldkuwcc7 109 10 ) ) -RRB- cord-287123-ldkuwcc7 109 11 from from IN cord-287123-ldkuwcc7 109 12 Helicobacter Helicobacter NNP cord-287123-ldkuwcc7 109 13 pylori pylori NN cord-287123-ldkuwcc7 109 14 was be VBD cord-287123-ldkuwcc7 109 15 also also RB cord-287123-ldkuwcc7 109 16 identified identify VBN cord-287123-ldkuwcc7 109 17 as as IN cord-287123-ldkuwcc7 109 18 an an DT cord-287123-ldkuwcc7 109 19 agonist agonist NN cord-287123-ldkuwcc7 109 20 for for IN cord-287123-ldkuwcc7 109 21 FPRs fpr NNS cord-287123-ldkuwcc7 109 22 [ [ -LRB- cord-287123-ldkuwcc7 109 23 55 55 CD cord-287123-ldkuwcc7 109 24 , , , cord-287123-ldkuwcc7 109 25 107 107 CD cord-287123-ldkuwcc7 109 26 ] ] -RRB- cord-287123-ldkuwcc7 109 27 . . . cord-287123-ldkuwcc7 110 1 The the DT cord-287123-ldkuwcc7 110 2 studies study NNS cord-287123-ldkuwcc7 110 3 demonstrated demonstrate VBD cord-287123-ldkuwcc7 110 4 that that IN cord-287123-ldkuwcc7 110 5 in in IN cord-287123-ldkuwcc7 110 6 H. H. NNP cord-287123-ldkuwcc7 110 7 pylori pylori NN cord-287123-ldkuwcc7 110 8 infection infection NN cord-287123-ldkuwcc7 110 9 , , , cord-287123-ldkuwcc7 110 10 Hp2 hp2 CD cord-287123-ldkuwcc7 110 11 - - SYM cord-287123-ldkuwcc7 110 12 20 20 CD cord-287123-ldkuwcc7 110 13 was be VBD cord-287123-ldkuwcc7 110 14 able able JJ cord-287123-ldkuwcc7 110 15 to to TO cord-287123-ldkuwcc7 110 16 induce induce VB cord-287123-ldkuwcc7 110 17 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 110 18 of of IN cord-287123-ldkuwcc7 110 19 monocytes monocyte NNS cord-287123-ldkuwcc7 110 20 and and CC cord-287123-ldkuwcc7 110 21 basophils basophil NNS cord-287123-ldkuwcc7 110 22 , , , cord-287123-ldkuwcc7 110 23 and and CC cord-287123-ldkuwcc7 110 24 evoke evoke VB cord-287123-ldkuwcc7 110 25 superoxide superoxide NN cord-287123-ldkuwcc7 110 26 release release NN cord-287123-ldkuwcc7 110 27 via via IN cord-287123-ldkuwcc7 110 28 signaling signal VBG cord-287123-ldkuwcc7 110 29 through through IN cord-287123-ldkuwcc7 110 30 FPR2 FPR2 NNP cord-287123-ldkuwcc7 110 31 and and CC cord-287123-ldkuwcc7 110 32 FPR3 FPR3 NNP cord-287123-ldkuwcc7 110 33 . . . cord-287123-ldkuwcc7 111 1 Recently recently RB cord-287123-ldkuwcc7 111 2 , , , cord-287123-ldkuwcc7 111 3 two two CD cord-287123-ldkuwcc7 111 4 antimicrobial antimicrobial JJ cord-287123-ldkuwcc7 111 5 peptides peptide NNS cord-287123-ldkuwcc7 111 6 ( ( -LRB- cord-287123-ldkuwcc7 111 7 AMPs amp NNS cord-287123-ldkuwcc7 111 8 ) ) -RRB- cord-287123-ldkuwcc7 111 9 isolated isolate VBN cord-287123-ldkuwcc7 111 10 from from IN cord-287123-ldkuwcc7 111 11 Scolopendra Scolopendra NNP cord-287123-ldkuwcc7 111 12 subspinipes subspinipes NNP cord-287123-ldkuwcc7 111 13 mutilans mutilans NNPS cord-287123-ldkuwcc7 111 14 were be VBD cord-287123-ldkuwcc7 111 15 reported report VBN cord-287123-ldkuwcc7 111 16 to to TO cord-287123-ldkuwcc7 111 17 elicit elicit VB cord-287123-ldkuwcc7 111 18 neutrophil neutrophil NN cord-287123-ldkuwcc7 111 19 chemotactic chemotactic JJ cord-287123-ldkuwcc7 111 20 migration migration NN cord-287123-ldkuwcc7 111 21 through through IN cord-287123-ldkuwcc7 111 22 FPR1 FPR1 NNP cord-287123-ldkuwcc7 111 23 [ [ -LRB- cord-287123-ldkuwcc7 111 24 108 108 CD cord-287123-ldkuwcc7 111 25 ] ] -RRB- cord-287123-ldkuwcc7 111 26 . . . cord-287123-ldkuwcc7 112 1 The the DT cord-287123-ldkuwcc7 112 2 host host NN cord-287123-ldkuwcc7 112 3 - - HYPH cord-287123-ldkuwcc7 112 4 derived derive VBN cord-287123-ldkuwcc7 112 5 non non JJ cord-287123-ldkuwcc7 112 6 - - JJ cord-287123-ldkuwcc7 112 7 formyl formyl JJ cord-287123-ldkuwcc7 112 8 peptide peptide NN cord-287123-ldkuwcc7 112 9 agonists agonist NNS cord-287123-ldkuwcc7 112 10 for for IN cord-287123-ldkuwcc7 112 11 FPRs fpr NNS cord-287123-ldkuwcc7 112 12 are be VBP cord-287123-ldkuwcc7 112 13 generally generally RB cord-287123-ldkuwcc7 112 14 peptides peptide NNS cord-287123-ldkuwcc7 112 15 and and CC cord-287123-ldkuwcc7 112 16 proteins protein NNS cord-287123-ldkuwcc7 112 17 associated associate VBN cord-287123-ldkuwcc7 112 18 with with IN cord-287123-ldkuwcc7 112 19 human human JJ cord-287123-ldkuwcc7 112 20 diseases disease NNS cord-287123-ldkuwcc7 112 21 and and CC cord-287123-ldkuwcc7 112 22 inflammation inflammation NN cord-287123-ldkuwcc7 112 23 . . . cord-287123-ldkuwcc7 113 1 This this DT cord-287123-ldkuwcc7 113 2 group group NN cord-287123-ldkuwcc7 113 3 of of IN cord-287123-ldkuwcc7 113 4 agonists agonist NNS cord-287123-ldkuwcc7 113 5 activates activate VBZ cord-287123-ldkuwcc7 113 6 FPRs FPRs NNP cord-287123-ldkuwcc7 113 7 independently independently RB cord-287123-ldkuwcc7 113 8 of of IN cord-287123-ldkuwcc7 113 9 the the DT cord-287123-ldkuwcc7 113 10 N N NNP cord-287123-ldkuwcc7 113 11 - - HYPH cord-287123-ldkuwcc7 113 12 formyl formyl NNP cord-287123-ldkuwcc7 113 13 group group NN cord-287123-ldkuwcc7 113 14 and and CC cord-287123-ldkuwcc7 113 15 they -PRON- PRP cord-287123-ldkuwcc7 113 16 also also RB cord-287123-ldkuwcc7 113 17 show show VBP cord-287123-ldkuwcc7 113 18 a a DT cord-287123-ldkuwcc7 113 19 preference preference NN cord-287123-ldkuwcc7 113 20 for for IN cord-287123-ldkuwcc7 113 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 113 22 . . . cord-287123-ldkuwcc7 114 1 A a DT cord-287123-ldkuwcc7 114 2 prominent prominent JJ cord-287123-ldkuwcc7 114 3 example example NN cord-287123-ldkuwcc7 114 4 of of IN cord-287123-ldkuwcc7 114 5 them -PRON- PRP cord-287123-ldkuwcc7 114 6 is be VBZ cord-287123-ldkuwcc7 114 7 serum serum NN cord-287123-ldkuwcc7 114 8 amyloid amyloid NN cord-287123-ldkuwcc7 114 9 A A NNP cord-287123-ldkuwcc7 114 10 ( ( -LRB- cord-287123-ldkuwcc7 114 11 SAA SAA NNP cord-287123-ldkuwcc7 114 12 ) ) -RRB- cord-287123-ldkuwcc7 114 13 , , , cord-287123-ldkuwcc7 114 14 an an DT cord-287123-ldkuwcc7 114 15 acute acute JJ cord-287123-ldkuwcc7 114 16 - - HYPH cord-287123-ldkuwcc7 114 17 phase phase NN cord-287123-ldkuwcc7 114 18 protein protein NN cord-287123-ldkuwcc7 114 19 that that WDT cord-287123-ldkuwcc7 114 20 is be VBZ cord-287123-ldkuwcc7 114 21 implicated implicate VBN cord-287123-ldkuwcc7 114 22 in in IN cord-287123-ldkuwcc7 114 23 chronic chronic JJ cord-287123-ldkuwcc7 114 24 inflammation inflammation NN cord-287123-ldkuwcc7 114 25 and and CC cord-287123-ldkuwcc7 114 26 amyloidosis amyloidosis NN cord-287123-ldkuwcc7 114 27 . . . cord-287123-ldkuwcc7 115 1 As as IN cord-287123-ldkuwcc7 115 2 the the DT cord-287123-ldkuwcc7 115 3 first first JJ cord-287123-ldkuwcc7 115 4 identified identify VBN cord-287123-ldkuwcc7 115 5 endogenous endogenous JJ cord-287123-ldkuwcc7 115 6 peptide peptide NN cord-287123-ldkuwcc7 115 7 agonist agonist NN cord-287123-ldkuwcc7 115 8 for for IN cord-287123-ldkuwcc7 115 9 FPR fpr NN cord-287123-ldkuwcc7 115 10 [ [ -LRB- cord-287123-ldkuwcc7 115 11 56 56 CD cord-287123-ldkuwcc7 115 12 ] ] -RRB- cord-287123-ldkuwcc7 115 13 , , , cord-287123-ldkuwcc7 115 14 documented document VBN cord-287123-ldkuwcc7 115 15 studies study NNS cord-287123-ldkuwcc7 115 16 have have VBP cord-287123-ldkuwcc7 115 17 shown show VBN cord-287123-ldkuwcc7 115 18 that that IN cord-287123-ldkuwcc7 115 19 it -PRON- PRP cord-287123-ldkuwcc7 115 20 exerts exert VBZ cord-287123-ldkuwcc7 115 21 pro pro JJ cord-287123-ldkuwcc7 115 22 - - JJ cord-287123-ldkuwcc7 115 23 inflammatory inflammatory JJ cord-287123-ldkuwcc7 115 24 activities activity NNS cord-287123-ldkuwcc7 115 25 through through IN cord-287123-ldkuwcc7 115 26 FPR2 FPR2 NNP cord-287123-ldkuwcc7 115 27 in in IN cord-287123-ldkuwcc7 115 28 phagocytes phagocyte NNS cord-287123-ldkuwcc7 115 29 , , , cord-287123-ldkuwcc7 115 30 epithelial epithelial JJ cord-287123-ldkuwcc7 115 31 cells cell NNS cord-287123-ldkuwcc7 115 32 and and CC cord-287123-ldkuwcc7 115 33 T t NN cord-287123-ldkuwcc7 115 34 lymphocytes lymphocyte NNS cord-287123-ldkuwcc7 115 35 , , , cord-287123-ldkuwcc7 115 36 including include VBG cord-287123-ldkuwcc7 115 37 stimulating stimulate VBG cord-287123-ldkuwcc7 115 38 production production NN cord-287123-ldkuwcc7 115 39 of of IN cord-287123-ldkuwcc7 115 40 inflammatory inflammatory JJ cord-287123-ldkuwcc7 115 41 mediators mediator NNS cord-287123-ldkuwcc7 115 42 and and CC cord-287123-ldkuwcc7 115 43 enhancing enhance VBG cord-287123-ldkuwcc7 115 44 the the DT cord-287123-ldkuwcc7 115 45 expression expression NN cord-287123-ldkuwcc7 115 46 of of IN cord-287123-ldkuwcc7 115 47 cytokine cytokine NN cord-287123-ldkuwcc7 115 48 receptors receptor NNS cord-287123-ldkuwcc7 115 49 [ [ -LRB- cord-287123-ldkuwcc7 115 50 109 109 CD cord-287123-ldkuwcc7 115 51 ] ] -RRB- cord-287123-ldkuwcc7 115 52 [ [ -LRB- cord-287123-ldkuwcc7 115 53 110 110 CD cord-287123-ldkuwcc7 115 54 ] ] -RRB- cord-287123-ldkuwcc7 115 55 [ [ -LRB- cord-287123-ldkuwcc7 115 56 111 111 CD cord-287123-ldkuwcc7 115 57 ] ] -RRB- cord-287123-ldkuwcc7 115 58 [ [ -LRB- cord-287123-ldkuwcc7 115 59 112 112 CD cord-287123-ldkuwcc7 115 60 ] ] -RRB- cord-287123-ldkuwcc7 115 61 [ [ -LRB- cord-287123-ldkuwcc7 115 62 113 113 CD cord-287123-ldkuwcc7 115 63 ] ] -RRB- cord-287123-ldkuwcc7 115 64 . . . cord-287123-ldkuwcc7 116 1 Recently recently RB cord-287123-ldkuwcc7 116 2 , , , cord-287123-ldkuwcc7 116 3 questions question NNS cord-287123-ldkuwcc7 116 4 have have VBP cord-287123-ldkuwcc7 116 5 been be VBN cord-287123-ldkuwcc7 116 6 raised raise VBN cord-287123-ldkuwcc7 116 7 regarding regard VBG cord-287123-ldkuwcc7 116 8 the the DT cord-287123-ldkuwcc7 116 9 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 116 10 cytokine cytokine NN cord-287123-ldkuwcc7 116 11 - - HYPH cord-287123-ldkuwcc7 116 12 like like JJ cord-287123-ldkuwcc7 116 13 properties property NNS cord-287123-ldkuwcc7 116 14 of of IN cord-287123-ldkuwcc7 116 15 native native JJ cord-287123-ldkuwcc7 116 16 SAA SAA NNP cord-287123-ldkuwcc7 116 17 , , , cord-287123-ldkuwcc7 116 18 since since IN cord-287123-ldkuwcc7 116 19 most most JJS cord-287123-ldkuwcc7 116 20 studies study NNS cord-287123-ldkuwcc7 116 21 of of IN cord-287123-ldkuwcc7 116 22 SAA SAA NNP cord-287123-ldkuwcc7 116 23 and and CC cord-287123-ldkuwcc7 116 24 FPR2 FPR2 NNP cord-287123-ldkuwcc7 116 25 are be VBP cord-287123-ldkuwcc7 116 26 performed perform VBN cord-287123-ldkuwcc7 116 27 using use VBG cord-287123-ldkuwcc7 116 28 a a DT cord-287123-ldkuwcc7 116 29 commercially commercially RB cord-287123-ldkuwcc7 116 30 available available JJ cord-287123-ldkuwcc7 116 31 recombinant recombinant JJ cord-287123-ldkuwcc7 116 32 protein protein NN cord-287123-ldkuwcc7 116 33 that that WDT cord-287123-ldkuwcc7 116 34 contains contain VBZ cord-287123-ldkuwcc7 116 35 amino amino JJ cord-287123-ldkuwcc7 116 36 acid acid NN cord-287123-ldkuwcc7 116 37 substitutions substitution NNS cord-287123-ldkuwcc7 116 38 of of IN cord-287123-ldkuwcc7 116 39 SAA2 SAA2 NNP cord-287123-ldkuwcc7 116 40 in in IN cord-287123-ldkuwcc7 116 41 SAA1 SAA1 NNP cord-287123-ldkuwcc7 116 42 [ [ -LRB- cord-287123-ldkuwcc7 116 43 5 5 CD cord-287123-ldkuwcc7 116 44 , , , cord-287123-ldkuwcc7 116 45 114 114 CD cord-287123-ldkuwcc7 116 46 , , , cord-287123-ldkuwcc7 116 47 115 115 CD cord-287123-ldkuwcc7 116 48 ] ] -RRB- cord-287123-ldkuwcc7 116 49 . . . cord-287123-ldkuwcc7 117 1 However however RB cord-287123-ldkuwcc7 117 2 , , , cord-287123-ldkuwcc7 117 3 research research NN cord-287123-ldkuwcc7 117 4 conducted conduct VBN cord-287123-ldkuwcc7 117 5 with with IN cord-287123-ldkuwcc7 117 6 SAA1 SAA1 NNP cord-287123-ldkuwcc7 117 7 isoforms isoform NNS cord-287123-ldkuwcc7 117 8 purified purify VBN cord-287123-ldkuwcc7 117 9 from from IN cord-287123-ldkuwcc7 117 10 an an DT cord-287123-ldkuwcc7 117 11 E. E. NNP cord-287123-ldkuwcc7 117 12 coli coli NN cord-287123-ldkuwcc7 117 13 expression expression NN cord-287123-ldkuwcc7 117 14 system system NN cord-287123-ldkuwcc7 117 15 suggested suggest VBD cord-287123-ldkuwcc7 117 16 that that IN cord-287123-ldkuwcc7 117 17 major major JJ cord-287123-ldkuwcc7 117 18 SAA1 SAA1 NNP cord-287123-ldkuwcc7 117 19 isoforms isoform NNS cord-287123-ldkuwcc7 117 20 have have VBP cord-287123-ldkuwcc7 117 21 cytokine cytokine NN cord-287123-ldkuwcc7 117 22 - - HYPH cord-287123-ldkuwcc7 117 23 inducing induce VBG cord-287123-ldkuwcc7 117 24 activity activity NN cord-287123-ldkuwcc7 117 25 and and CC cord-287123-ldkuwcc7 117 26 minor minor JJ cord-287123-ldkuwcc7 117 27 substitutions substitution NNS cord-287123-ldkuwcc7 117 28 of of IN cord-287123-ldkuwcc7 117 29 amino amino JJ cord-287123-ldkuwcc7 117 30 acids acid NNS cord-287123-ldkuwcc7 117 31 affected affect VBD cord-287123-ldkuwcc7 117 32 their -PRON- PRP$ cord-287123-ldkuwcc7 117 33 potency potency NN cord-287123-ldkuwcc7 117 34 at at IN cord-287123-ldkuwcc7 117 35 FPR2 FPR2 NNP cord-287123-ldkuwcc7 117 36 [ [ -LRB- cord-287123-ldkuwcc7 117 37 116 116 CD cord-287123-ldkuwcc7 117 38 ] ] -RRB- cord-287123-ldkuwcc7 117 39 . . . cord-287123-ldkuwcc7 118 1 In in IN cord-287123-ldkuwcc7 118 2 vivo vivo NN cord-287123-ldkuwcc7 118 3 studies study NNS cord-287123-ldkuwcc7 118 4 have have VBP cord-287123-ldkuwcc7 118 5 shown show VBN cord-287123-ldkuwcc7 118 6 Th17-induction th17-induction NN cord-287123-ldkuwcc7 118 7 activity activity NN cord-287123-ldkuwcc7 118 8 of of IN cord-287123-ldkuwcc7 118 9 SAA SAA NNP cord-287123-ldkuwcc7 118 10 in in IN cord-287123-ldkuwcc7 118 11 gut gut NN cord-287123-ldkuwcc7 118 12 epithelium epithelium NN cord-287123-ldkuwcc7 118 13 , , , cord-287123-ldkuwcc7 118 14 although although IN cord-287123-ldkuwcc7 118 15 whether whether IN cord-287123-ldkuwcc7 118 16 these these DT cord-287123-ldkuwcc7 118 17 activities activity NNS cord-287123-ldkuwcc7 118 18 are be VBP cord-287123-ldkuwcc7 118 19 attributed attribute VBN cord-287123-ldkuwcc7 118 20 to to IN cord-287123-ldkuwcc7 118 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 118 22 or or CC cord-287123-ldkuwcc7 118 23 other other JJ cord-287123-ldkuwcc7 118 24 SAA SAA NNP cord-287123-ldkuwcc7 118 25 receptors receptor NNS cord-287123-ldkuwcc7 118 26 remain remain VBP cord-287123-ldkuwcc7 118 27 unclear unclear JJ cord-287123-ldkuwcc7 118 28 [ [ -LRB- cord-287123-ldkuwcc7 118 29 117 117 CD cord-287123-ldkuwcc7 118 30 , , , cord-287123-ldkuwcc7 118 31 118 118 CD cord-287123-ldkuwcc7 118 32 ] ] -RRB- cord-287123-ldkuwcc7 118 33 . . . cord-287123-ldkuwcc7 119 1 Another another DT cord-287123-ldkuwcc7 119 2 amyloidogenic amyloidogenic NNP cord-287123-ldkuwcc7 119 3 disease disease NN cord-287123-ldkuwcc7 119 4 - - HYPH cord-287123-ldkuwcc7 119 5 associated associate VBN cord-287123-ldkuwcc7 119 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 119 7 agonist agonist NN cord-287123-ldkuwcc7 119 8 is be VBZ cord-287123-ldkuwcc7 119 9 the the DT cord-287123-ldkuwcc7 119 10 prion prion NN cord-287123-ldkuwcc7 119 11 protein protein NN cord-287123-ldkuwcc7 119 12 fragment fragment NN cord-287123-ldkuwcc7 119 13 PrP prp NN cord-287123-ldkuwcc7 119 14 , , , cord-287123-ldkuwcc7 119 15 which which WDT cord-287123-ldkuwcc7 119 16 was be VBD cord-287123-ldkuwcc7 119 17 reported report VBN cord-287123-ldkuwcc7 119 18 to to TO cord-287123-ldkuwcc7 119 19 interact interact VB cord-287123-ldkuwcc7 119 20 with with IN cord-287123-ldkuwcc7 119 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 119 22 in in IN cord-287123-ldkuwcc7 119 23 glial glial JJ cord-287123-ldkuwcc7 119 24 cells cell NNS cord-287123-ldkuwcc7 119 25 and and CC cord-287123-ldkuwcc7 119 26 induce induce VB cord-287123-ldkuwcc7 119 27 calcium calcium NN cord-287123-ldkuwcc7 119 28 mobilization mobilization NN cord-287123-ldkuwcc7 119 29 , , , cord-287123-ldkuwcc7 119 30 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 119 31 as as RB cord-287123-ldkuwcc7 119 32 well well RB cord-287123-ldkuwcc7 119 33 as as IN cord-287123-ldkuwcc7 119 34 production production NN cord-287123-ldkuwcc7 119 35 of of IN cord-287123-ldkuwcc7 119 36 pro pro JJ cord-287123-ldkuwcc7 119 37 - - JJ cord-287123-ldkuwcc7 119 38 inflammatory inflammatory JJ cord-287123-ldkuwcc7 119 39 cytokines cytokine NNS cord-287123-ldkuwcc7 119 40 [ [ -LRB- cord-287123-ldkuwcc7 119 41 64 64 CD cord-287123-ldkuwcc7 119 42 ] ] -RRB- cord-287123-ldkuwcc7 119 43 . . . cord-287123-ldkuwcc7 120 1 In in IN cord-287123-ldkuwcc7 120 2 addition addition NN cord-287123-ldkuwcc7 120 3 to to IN cord-287123-ldkuwcc7 120 4 SAA SAA NNP cord-287123-ldkuwcc7 120 5 and and CC cord-287123-ldkuwcc7 120 6 PrP prp NN cord-287123-ldkuwcc7 120 7 , , , cord-287123-ldkuwcc7 120 8 other other JJ cord-287123-ldkuwcc7 120 9 two two CD cord-287123-ldkuwcc7 120 10 amyloidogenic amyloidogenic NNP cord-287123-ldkuwcc7 120 11 disease disease NN cord-287123-ldkuwcc7 120 12 - - HYPH cord-287123-ldkuwcc7 120 13 associated associate VBN cord-287123-ldkuwcc7 120 14 peptides peptide NNS cord-287123-ldkuwcc7 120 15 were be VBD cord-287123-ldkuwcc7 120 16 found find VBN cord-287123-ldkuwcc7 120 17 to to TO cord-287123-ldkuwcc7 120 18 be be VB cord-287123-ldkuwcc7 120 19 agonists agonist NNS cord-287123-ldkuwcc7 120 20 for for IN cord-287123-ldkuwcc7 120 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 120 22 : : : cord-287123-ldkuwcc7 120 23 the the DT cord-287123-ldkuwcc7 120 24 42-amino 42-amino CD cord-287123-ldkuwcc7 120 25 acid acid NN cord-287123-ldkuwcc7 120 26 form form NN cord-287123-ldkuwcc7 120 27 of of IN cord-287123-ldkuwcc7 120 28 Aβ Aβ NNP cord-287123-ldkuwcc7 120 29 amyloid amyloid NN cord-287123-ldkuwcc7 120 30 peptide peptide NN cord-287123-ldkuwcc7 120 31 ( ( -LRB- cord-287123-ldkuwcc7 120 32 Aβ Aβ NNP cord-287123-ldkuwcc7 120 33 42 42 CD cord-287123-ldkuwcc7 120 34 ) ) -RRB- cord-287123-ldkuwcc7 120 35 and and CC cord-287123-ldkuwcc7 120 36 humanin humanin NNS cord-287123-ldkuwcc7 120 37 . . . cord-287123-ldkuwcc7 121 1 Although although IN cord-287123-ldkuwcc7 121 2 both both DT cord-287123-ldkuwcc7 121 3 peptides peptide NNS cord-287123-ldkuwcc7 121 4 use use VBP cord-287123-ldkuwcc7 121 5 FPR2 FPR2 NNP cord-287123-ldkuwcc7 121 6 to to TO cord-287123-ldkuwcc7 121 7 induce induce VB cord-287123-ldkuwcc7 121 8 migration migration NN cord-287123-ldkuwcc7 121 9 and and CC cord-287123-ldkuwcc7 121 10 activation activation NN cord-287123-ldkuwcc7 121 11 of of IN cord-287123-ldkuwcc7 121 12 monocytic monocytic JJ cord-287123-ldkuwcc7 121 13 phagocytes phagocyte NNS cord-287123-ldkuwcc7 121 14 in in IN cord-287123-ldkuwcc7 121 15 the the DT cord-287123-ldkuwcc7 121 16 brain brain NN cord-287123-ldkuwcc7 121 17 , , , cord-287123-ldkuwcc7 121 18 Aβ Aβ NNP cord-287123-ldkuwcc7 121 19 42 42 CD cord-287123-ldkuwcc7 121 20 and and CC cord-287123-ldkuwcc7 121 21 humanin humanin NNS cord-287123-ldkuwcc7 121 22 display display VBP cord-287123-ldkuwcc7 121 23 divergent divergent JJ cord-287123-ldkuwcc7 121 24 roles role NNS cord-287123-ldkuwcc7 121 25 in in IN cord-287123-ldkuwcc7 121 26 the the DT cord-287123-ldkuwcc7 121 27 development development NN cord-287123-ldkuwcc7 121 28 of of IN cord-287123-ldkuwcc7 121 29 Alzheimer Alzheimer NNP cord-287123-ldkuwcc7 121 30 's 's POS cord-287123-ldkuwcc7 121 31 disease disease NN cord-287123-ldkuwcc7 121 32 : : : cord-287123-ldkuwcc7 122 1 Aβ Aβ NNP cord-287123-ldkuwcc7 122 2 42 42 CD cord-287123-ldkuwcc7 122 3 is be VBZ cord-287123-ldkuwcc7 122 4 a a DT cord-287123-ldkuwcc7 122 5 major major JJ cord-287123-ldkuwcc7 122 6 cause cause NN cord-287123-ldkuwcc7 122 7 of of IN cord-287123-ldkuwcc7 122 8 fibrillary fibrillary JJ cord-287123-ldkuwcc7 122 9 formation formation NN cord-287123-ldkuwcc7 122 10 and and CC cord-287123-ldkuwcc7 122 11 deposition deposition NN cord-287123-ldkuwcc7 122 12 in in IN cord-287123-ldkuwcc7 122 13 brain brain NN cord-287123-ldkuwcc7 122 14 of of IN cord-287123-ldkuwcc7 122 15 AD ad NN cord-287123-ldkuwcc7 122 16 patients patient NNS cord-287123-ldkuwcc7 122 17 [ [ -LRB- cord-287123-ldkuwcc7 122 18 119 119 CD cord-287123-ldkuwcc7 122 19 , , , cord-287123-ldkuwcc7 122 20 120 120 CD cord-287123-ldkuwcc7 122 21 ] ] -RRB- cord-287123-ldkuwcc7 122 22 , , , cord-287123-ldkuwcc7 122 23 whereas whereas IN cord-287123-ldkuwcc7 122 24 humanin humanin NNP cord-287123-ldkuwcc7 122 25 is be VBZ cord-287123-ldkuwcc7 122 26 neuroprotective neuroprotective JJ cord-287123-ldkuwcc7 122 27 on on IN cord-287123-ldkuwcc7 122 28 the the DT cord-287123-ldkuwcc7 122 29 contrary contrary NN cord-287123-ldkuwcc7 122 30 [ [ -LRB- cord-287123-ldkuwcc7 122 31 121 121 CD cord-287123-ldkuwcc7 122 32 ] ] -RRB- cord-287123-ldkuwcc7 122 33 . . . cord-287123-ldkuwcc7 123 1 Studies study NNS cord-287123-ldkuwcc7 123 2 suggested suggest VBD cord-287123-ldkuwcc7 123 3 that that IN cord-287123-ldkuwcc7 123 4 humanin humanin NNP cord-287123-ldkuwcc7 123 5 reduces reduce VBZ cord-287123-ldkuwcc7 123 6 aggregation aggregation NN cord-287123-ldkuwcc7 123 7 and and CC cord-287123-ldkuwcc7 123 8 fibrillary fibrillary NN cord-287123-ldkuwcc7 123 9 formation formation NN cord-287123-ldkuwcc7 123 10 by by IN cord-287123-ldkuwcc7 123 11 inhibiting inhibit VBG cord-287123-ldkuwcc7 123 12 Aβ Aβ NNP cord-287123-ldkuwcc7 123 13 42 42 CD cord-287123-ldkuwcc7 123 14 /FPR2 /FPR2 . cord-287123-ldkuwcc7 123 15 interaction interaction NN cord-287123-ldkuwcc7 123 16 in in IN cord-287123-ldkuwcc7 123 17 mononuclear mononuclear JJ cord-287123-ldkuwcc7 123 18 phagocytes phagocyte NNS cord-287123-ldkuwcc7 123 19 [ [ -LRB- cord-287123-ldkuwcc7 123 20 121 121 CD cord-287123-ldkuwcc7 123 21 ] ] -RRB- cord-287123-ldkuwcc7 123 22 . . . cord-287123-ldkuwcc7 124 1 FPR3 fpr3 JJ cord-287123-ldkuwcc7 124 2 and and CC cord-287123-ldkuwcc7 124 3 mFpr2 mfpr2 NN cord-287123-ldkuwcc7 124 4 are be VBP cord-287123-ldkuwcc7 124 5 also also RB cord-287123-ldkuwcc7 124 6 functional functional JJ cord-287123-ldkuwcc7 124 7 receptors receptor NNS cord-287123-ldkuwcc7 124 8 for for IN cord-287123-ldkuwcc7 124 9 humanin humanin NNS cord-287123-ldkuwcc7 124 10 in in IN cord-287123-ldkuwcc7 124 11 humans human NNS cord-287123-ldkuwcc7 124 12 and and CC cord-287123-ldkuwcc7 124 13 mice mouse NNS cord-287123-ldkuwcc7 124 14 , , , cord-287123-ldkuwcc7 124 15 respectively respectively RB cord-287123-ldkuwcc7 124 16 [ [ -LRB- cord-287123-ldkuwcc7 124 17 121 121 CD cord-287123-ldkuwcc7 124 18 , , , cord-287123-ldkuwcc7 124 19 122 122 CD cord-287123-ldkuwcc7 124 20 ] ] -RRB- cord-287123-ldkuwcc7 124 21 . . . cord-287123-ldkuwcc7 125 1 Annexin Annexin NNP cord-287123-ldkuwcc7 125 2 A1 A1 NNP cord-287123-ldkuwcc7 125 3 , , , cord-287123-ldkuwcc7 125 4 a a DT cord-287123-ldkuwcc7 125 5 glucocorticoid glucocorticoid NN cord-287123-ldkuwcc7 125 6 - - HYPH cord-287123-ldkuwcc7 125 7 regulated regulate VBN cord-287123-ldkuwcc7 125 8 protein protein NN cord-287123-ldkuwcc7 125 9 , , , cord-287123-ldkuwcc7 125 10 and and CC cord-287123-ldkuwcc7 125 11 its -PRON- PRP$ cord-287123-ldkuwcc7 125 12 N n CD cord-287123-ldkuwcc7 125 13 - - HYPH cord-287123-ldkuwcc7 125 14 terminal terminal NN cord-287123-ldkuwcc7 125 15 peptides peptide NNS cord-287123-ldkuwcc7 125 16 ( ( -LRB- cord-287123-ldkuwcc7 125 17 Ac2 Ac2 NNP cord-287123-ldkuwcc7 125 18 - - SYM cord-287123-ldkuwcc7 125 19 26 26 CD cord-287123-ldkuwcc7 125 20 and and CC cord-287123-ldkuwcc7 125 21 Ac9 ac9 CD cord-287123-ldkuwcc7 125 22 - - HYPH cord-287123-ldkuwcc7 125 23 25 25 CD cord-287123-ldkuwcc7 125 24 ) ) -RRB- cord-287123-ldkuwcc7 125 25 are be VBP cord-287123-ldkuwcc7 125 26 FPR FPR NNP cord-287123-ldkuwcc7 125 27 agonists agonist NNS cord-287123-ldkuwcc7 125 28 that that WDT cord-287123-ldkuwcc7 125 29 have have VBP cord-287123-ldkuwcc7 125 30 dual dual JJ cord-287123-ldkuwcc7 125 31 roles role NNS cord-287123-ldkuwcc7 125 32 in in IN cord-287123-ldkuwcc7 125 33 inflammation inflammation NN cord-287123-ldkuwcc7 125 34 . . . cord-287123-ldkuwcc7 126 1 At at IN cord-287123-ldkuwcc7 126 2 high high JJ cord-287123-ldkuwcc7 126 3 concentrations concentration NNS cord-287123-ldkuwcc7 126 4 , , , cord-287123-ldkuwcc7 126 5 the the DT cord-287123-ldkuwcc7 126 6 annexin annexin JJ cord-287123-ldkuwcc7 126 7 A1 A1 NNP cord-287123-ldkuwcc7 126 8 peptides peptide NNS cord-287123-ldkuwcc7 126 9 fully fully RB cord-287123-ldkuwcc7 126 10 activate activate VBP cord-287123-ldkuwcc7 126 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 126 12 like like IN cord-287123-ldkuwcc7 126 13 the the DT cord-287123-ldkuwcc7 126 14 conventional conventional JJ cord-287123-ldkuwcc7 126 15 agonists agonist NNS cord-287123-ldkuwcc7 126 16 that that WDT cord-287123-ldkuwcc7 126 17 induce induce VBP cord-287123-ldkuwcc7 126 18 pro pro JJ cord-287123-ldkuwcc7 126 19 - - JJ cord-287123-ldkuwcc7 126 20 inflammatory inflammatory JJ cord-287123-ldkuwcc7 126 21 responses response NNS cord-287123-ldkuwcc7 126 22 . . . cord-287123-ldkuwcc7 127 1 In in IN cord-287123-ldkuwcc7 127 2 contrast contrast NN cord-287123-ldkuwcc7 127 3 , , , cord-287123-ldkuwcc7 127 4 at at IN cord-287123-ldkuwcc7 127 5 low low JJ cord-287123-ldkuwcc7 127 6 concentrations concentration NNS cord-287123-ldkuwcc7 127 7 they -PRON- PRP cord-287123-ldkuwcc7 127 8 only only RB cord-287123-ldkuwcc7 127 9 show show VBP cord-287123-ldkuwcc7 127 10 partial partial JJ cord-287123-ldkuwcc7 127 11 activity activity NN cord-287123-ldkuwcc7 127 12 at at IN cord-287123-ldkuwcc7 127 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 127 14 [ [ -LRB- cord-287123-ldkuwcc7 127 15 123 123 CD cord-287123-ldkuwcc7 127 16 ] ] -RRB- cord-287123-ldkuwcc7 127 17 , , , cord-287123-ldkuwcc7 127 18 leading lead VBG cord-287123-ldkuwcc7 127 19 to to IN cord-287123-ldkuwcc7 127 20 neutrophil neutrophil NN cord-287123-ldkuwcc7 127 21 desensitization desensitization NN cord-287123-ldkuwcc7 127 22 and and CC cord-287123-ldkuwcc7 127 23 inhibiting inhibit VBG cord-287123-ldkuwcc7 127 24 neutrophil neutrophil NN cord-287123-ldkuwcc7 127 25 migration migration NN cord-287123-ldkuwcc7 127 26 induced induce VBN cord-287123-ldkuwcc7 127 27 by by IN cord-287123-ldkuwcc7 127 28 other other JJ cord-287123-ldkuwcc7 127 29 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 127 30 . . . cord-287123-ldkuwcc7 128 1 All all DT cord-287123-ldkuwcc7 128 2 three three CD cord-287123-ldkuwcc7 128 3 FPR FPR NNP cord-287123-ldkuwcc7 128 4 members member NNS cord-287123-ldkuwcc7 128 5 are be VBP cord-287123-ldkuwcc7 128 6 implicated implicate VBN cord-287123-ldkuwcc7 128 7 in in IN cord-287123-ldkuwcc7 128 8 the the DT cord-287123-ldkuwcc7 128 9 various various JJ cord-287123-ldkuwcc7 128 10 functions function NNS cord-287123-ldkuwcc7 128 11 of of IN cord-287123-ldkuwcc7 128 12 annexin annexin NNP cord-287123-ldkuwcc7 128 13 A1 A1 NNP cord-287123-ldkuwcc7 128 14 peptides peptide NNS cord-287123-ldkuwcc7 128 15 . . . cord-287123-ldkuwcc7 129 1 Some some DT cord-287123-ldkuwcc7 129 2 researchers researcher NNS cord-287123-ldkuwcc7 129 3 thought think VBD cord-287123-ldkuwcc7 129 4 that that IN cord-287123-ldkuwcc7 129 5 these these DT cord-287123-ldkuwcc7 129 6 peptides peptide NNS cord-287123-ldkuwcc7 129 7 use use VBP cord-287123-ldkuwcc7 129 8 FPR2 FPR2 NNP cord-287123-ldkuwcc7 129 9 for for IN cord-287123-ldkuwcc7 129 10 anti anti JJ cord-287123-ldkuwcc7 129 11 - - JJ cord-287123-ldkuwcc7 129 12 inflammatory inflammatory JJ cord-287123-ldkuwcc7 129 13 actions action NNS cord-287123-ldkuwcc7 129 14 [ [ -LRB- cord-287123-ldkuwcc7 129 15 59 59 CD cord-287123-ldkuwcc7 129 16 ] ] -RRB- cord-287123-ldkuwcc7 129 17 , , , cord-287123-ldkuwcc7 129 18 while while IN cord-287123-ldkuwcc7 129 19 others other NNS cord-287123-ldkuwcc7 129 20 suggested suggest VBD cord-287123-ldkuwcc7 129 21 the the DT cord-287123-ldkuwcc7 129 22 presence presence NN cord-287123-ldkuwcc7 129 23 of of IN cord-287123-ldkuwcc7 129 24 receptors receptor NNS cord-287123-ldkuwcc7 129 25 other other JJ cord-287123-ldkuwcc7 129 26 than than IN cord-287123-ldkuwcc7 129 27 FPR2 FPR2 NNP cord-287123-ldkuwcc7 129 28 and and CC cord-287123-ldkuwcc7 129 29 FPR3 FPR3 NNP cord-287123-ldkuwcc7 129 30 as as IN cord-287123-ldkuwcc7 129 31 being be VBG cord-287123-ldkuwcc7 129 32 responsible responsible JJ cord-287123-ldkuwcc7 129 33 for for IN cord-287123-ldkuwcc7 129 34 the the DT cord-287123-ldkuwcc7 129 35 resolving resolve VBG cord-287123-ldkuwcc7 129 36 effects effect NNS cord-287123-ldkuwcc7 129 37 [ [ -LRB- cord-287123-ldkuwcc7 129 38 124 124 CD cord-287123-ldkuwcc7 129 39 ] ] -RRB- cord-287123-ldkuwcc7 129 40 . . . cord-287123-ldkuwcc7 130 1 The the DT cord-287123-ldkuwcc7 130 2 exact exact JJ cord-287123-ldkuwcc7 130 3 mechanism mechanism NN cord-287123-ldkuwcc7 130 4 for for IN cord-287123-ldkuwcc7 130 5 the the DT cord-287123-ldkuwcc7 130 6 pro-/anti pro-/anti JJ cord-287123-ldkuwcc7 130 7 - - HYPH cord-287123-ldkuwcc7 130 8 inflammatory inflammatory JJ cord-287123-ldkuwcc7 130 9 activity activity NN cord-287123-ldkuwcc7 130 10 of of IN cord-287123-ldkuwcc7 130 11 annexin annexin NNP cord-287123-ldkuwcc7 130 12 A1 A1 NNP cord-287123-ldkuwcc7 130 13 peptides peptide NNS cord-287123-ldkuwcc7 130 14 is be VBZ cord-287123-ldkuwcc7 130 15 not not RB cord-287123-ldkuwcc7 130 16 entirely entirely RB cord-287123-ldkuwcc7 130 17 clear clear JJ cord-287123-ldkuwcc7 130 18 . . . cord-287123-ldkuwcc7 131 1 The the DT cord-287123-ldkuwcc7 131 2 antimicrobial antimicrobial JJ cord-287123-ldkuwcc7 131 3 peptide peptide NN cord-287123-ldkuwcc7 131 4 LL-37 LL-37 NNP cord-287123-ldkuwcc7 131 5 and and CC cord-287123-ldkuwcc7 131 6 its -PRON- PRP$ cord-287123-ldkuwcc7 131 7 murine murine JJ cord-287123-ldkuwcc7 131 8 homolog homolog NN cord-287123-ldkuwcc7 131 9 CRAMP cramp NN cord-287123-ldkuwcc7 132 1 ( ( -LRB- cord-287123-ldkuwcc7 132 2 Cathelicidin Cathelicidin NNP cord-287123-ldkuwcc7 132 3 - - HYPH cord-287123-ldkuwcc7 132 4 Related Related NNP cord-287123-ldkuwcc7 132 5 Anti Anti NNP cord-287123-ldkuwcc7 132 6 - - NNP cord-287123-ldkuwcc7 132 7 Microbial Microbial NNP cord-287123-ldkuwcc7 132 8 Peptide Peptide NNP cord-287123-ldkuwcc7 132 9 ) ) -RRB- cord-287123-ldkuwcc7 132 10 were be VBD cord-287123-ldkuwcc7 132 11 identified identify VBN cord-287123-ldkuwcc7 132 12 as as IN cord-287123-ldkuwcc7 132 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 132 14 agonists agonist NNS cord-287123-ldkuwcc7 132 15 [ [ -LRB- cord-287123-ldkuwcc7 132 16 61 61 CD cord-287123-ldkuwcc7 132 17 , , , cord-287123-ldkuwcc7 132 18 125 125 CD cord-287123-ldkuwcc7 132 19 ] ] -RRB- cord-287123-ldkuwcc7 132 20 . . . cord-287123-ldkuwcc7 133 1 LL-37 LL-37 NNP cord-287123-ldkuwcc7 133 2 is be VBZ cord-287123-ldkuwcc7 133 3 a a DT cord-287123-ldkuwcc7 133 4 cleavage cleavage NN cord-287123-ldkuwcc7 133 5 product product NN cord-287123-ldkuwcc7 133 6 of of IN cord-287123-ldkuwcc7 133 7 the the DT cord-287123-ldkuwcc7 133 8 neutrophil neutrophil NN cord-287123-ldkuwcc7 133 9 granule granule NN cord-287123-ldkuwcc7 133 10 protein protein NN cord-287123-ldkuwcc7 133 11 cathelicidin cathelicidin NNP cord-287123-ldkuwcc7 133 12 found find VBD cord-287123-ldkuwcc7 133 13 in in IN cord-287123-ldkuwcc7 133 14 leukocytes leukocyte NNS cord-287123-ldkuwcc7 133 15 and and CC cord-287123-ldkuwcc7 133 16 epithelial epithelial JJ cord-287123-ldkuwcc7 133 17 cells cell NNS cord-287123-ldkuwcc7 133 18 . . . cord-287123-ldkuwcc7 134 1 As as IN cord-287123-ldkuwcc7 134 2 a a DT cord-287123-ldkuwcc7 134 3 pro pro JJ cord-287123-ldkuwcc7 134 4 - - JJ cord-287123-ldkuwcc7 134 5 inflammatory inflammatory JJ cord-287123-ldkuwcc7 134 6 mediator mediator NN cord-287123-ldkuwcc7 134 7 , , , cord-287123-ldkuwcc7 134 8 LL-37 LL-37 NNP cord-287123-ldkuwcc7 134 9 activates activate VBZ cord-287123-ldkuwcc7 134 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 134 11 and and CC cord-287123-ldkuwcc7 134 12 evokes evoke VBZ cord-287123-ldkuwcc7 134 13 superoxide superoxide NN cord-287123-ldkuwcc7 134 14 generation generation NN cord-287123-ldkuwcc7 134 15 in in IN cord-287123-ldkuwcc7 134 16 human human JJ cord-287123-ldkuwcc7 134 17 fibroblasts fibroblast NNS cord-287123-ldkuwcc7 134 18 [ [ -LRB- cord-287123-ldkuwcc7 134 19 126 126 CD cord-287123-ldkuwcc7 134 20 ] ] -RRB- cord-287123-ldkuwcc7 134 21 . . . cord-287123-ldkuwcc7 135 1 It -PRON- PRP cord-287123-ldkuwcc7 135 2 also also RB cord-287123-ldkuwcc7 135 3 induces induce VBZ cord-287123-ldkuwcc7 135 4 directional directional JJ cord-287123-ldkuwcc7 135 5 migration migration NN cord-287123-ldkuwcc7 135 6 of of IN cord-287123-ldkuwcc7 135 7 human human JJ cord-287123-ldkuwcc7 135 8 monocytes monocyte NNS cord-287123-ldkuwcc7 135 9 , , , cord-287123-ldkuwcc7 135 10 neutrophils neutrophil NNS cord-287123-ldkuwcc7 135 11 , , , cord-287123-ldkuwcc7 135 12 and and CC cord-287123-ldkuwcc7 135 13 T t NN cord-287123-ldkuwcc7 135 14 lymphocytes lymphocyte NNS cord-287123-ldkuwcc7 135 15 [ [ -LRB- cord-287123-ldkuwcc7 135 16 61 61 CD cord-287123-ldkuwcc7 135 17 ] ] -RRB- cord-287123-ldkuwcc7 135 18 . . . cord-287123-ldkuwcc7 136 1 However however RB cord-287123-ldkuwcc7 136 2 , , , cord-287123-ldkuwcc7 136 3 LL-37 LL-37 NNP cord-287123-ldkuwcc7 136 4 also also RB cord-287123-ldkuwcc7 136 5 inhibits inhibit VBZ cord-287123-ldkuwcc7 136 6 SAA SAA NNP cord-287123-ldkuwcc7 136 7 signaling signal VBG cord-287123-ldkuwcc7 136 8 in in IN cord-287123-ldkuwcc7 136 9 human human JJ cord-287123-ldkuwcc7 136 10 neutrophils neutrophil NNS cord-287123-ldkuwcc7 136 11 , , , cord-287123-ldkuwcc7 136 12 including include VBG cord-287123-ldkuwcc7 136 13 IL-8 il-8 NN cord-287123-ldkuwcc7 136 14 production production NN cord-287123-ldkuwcc7 136 15 and and CC cord-287123-ldkuwcc7 136 16 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 136 17 through through IN cord-287123-ldkuwcc7 136 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 136 19 [ [ -LRB- cord-287123-ldkuwcc7 136 20 127 127 CD cord-287123-ldkuwcc7 136 21 ] ] -RRB- cord-287123-ldkuwcc7 136 22 . . . cord-287123-ldkuwcc7 137 1 LL-37 LL-37 NNP cord-287123-ldkuwcc7 137 2 seems seem VBZ cord-287123-ldkuwcc7 137 3 to to TO cord-287123-ldkuwcc7 137 4 be be VB cord-287123-ldkuwcc7 137 5 a a DT cord-287123-ldkuwcc7 137 6 pleiotropic pleiotropic JJ cord-287123-ldkuwcc7 137 7 peptide peptide NN cord-287123-ldkuwcc7 137 8 and and CC cord-287123-ldkuwcc7 138 1 its -PRON- PRP$ cord-287123-ldkuwcc7 138 2 interaction interaction NN cord-287123-ldkuwcc7 138 3 with with IN cord-287123-ldkuwcc7 138 4 FPR2 FPR2 NNP cord-287123-ldkuwcc7 138 5 is be VBZ cord-287123-ldkuwcc7 138 6 implicated implicate VBN cord-287123-ldkuwcc7 138 7 in in IN cord-287123-ldkuwcc7 138 8 wound wound JJ cord-287123-ldkuwcc7 138 9 healing healing NN cord-287123-ldkuwcc7 138 10 , , , cord-287123-ldkuwcc7 138 11 cell cell NN cord-287123-ldkuwcc7 138 12 proliferation proliferation NN cord-287123-ldkuwcc7 138 13 [ [ -LRB- cord-287123-ldkuwcc7 138 14 128 128 CD cord-287123-ldkuwcc7 138 15 ] ] -RRB- cord-287123-ldkuwcc7 138 16 , , , cord-287123-ldkuwcc7 138 17 angiogenesis angiogenesis NN cord-287123-ldkuwcc7 138 18 [ [ -LRB- cord-287123-ldkuwcc7 138 19 129 129 CD cord-287123-ldkuwcc7 138 20 ] ] -RRB- cord-287123-ldkuwcc7 138 21 and and CC cord-287123-ldkuwcc7 138 22 anti anti JJ cord-287123-ldkuwcc7 138 23 - - JJ cord-287123-ldkuwcc7 138 24 or or CC cord-287123-ldkuwcc7 138 25 pro pro JJ cord-287123-ldkuwcc7 138 26 - - JJ cord-287123-ldkuwcc7 138 27 tumorigenesis tumorigenesis JJ cord-287123-ldkuwcc7 138 28 [ [ -LRB- cord-287123-ldkuwcc7 138 29 130 130 CD cord-287123-ldkuwcc7 138 30 ] ] -RRB- cord-287123-ldkuwcc7 138 31 [ [ -LRB- cord-287123-ldkuwcc7 138 32 131 131 CD cord-287123-ldkuwcc7 138 33 ] ] -RRB- cord-287123-ldkuwcc7 138 34 [ [ -LRB- cord-287123-ldkuwcc7 138 35 132 132 CD cord-287123-ldkuwcc7 138 36 ] ] -RRB- cord-287123-ldkuwcc7 138 37 . . . cord-287123-ldkuwcc7 139 1 In in IN cord-287123-ldkuwcc7 139 2 a a DT cord-287123-ldkuwcc7 139 3 recent recent JJ cord-287123-ldkuwcc7 139 4 study study NN cord-287123-ldkuwcc7 139 5 , , , cord-287123-ldkuwcc7 139 6 the the DT cord-287123-ldkuwcc7 139 7 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 139 8 circuits circuit NNS cord-287123-ldkuwcc7 139 9 of of IN cord-287123-ldkuwcc7 139 10 LL-37 LL-37 NNP cord-287123-ldkuwcc7 139 11 and and CC cord-287123-ldkuwcc7 139 12 leukotriene leukotriene NN cord-287123-ldkuwcc7 139 13 B4 B4 NNP cord-287123-ldkuwcc7 139 14 was be VBD cord-287123-ldkuwcc7 139 15 reported report VBN cord-287123-ldkuwcc7 139 16 . . . cord-287123-ldkuwcc7 140 1 In in IN cord-287123-ldkuwcc7 140 2 human human JJ cord-287123-ldkuwcc7 140 3 neutrophils neutrophil NNS cord-287123-ldkuwcc7 140 4 , , , cord-287123-ldkuwcc7 140 5 LL-37 LL-37 NNP cord-287123-ldkuwcc7 140 6 / / SYM cord-287123-ldkuwcc7 140 7 FPR2 FPR2 NNP cord-287123-ldkuwcc7 140 8 promotes promote VBZ cord-287123-ldkuwcc7 140 9 Leukotriene Leukotriene NNP cord-287123-ldkuwcc7 140 10 B4 B4 NNP cord-287123-ldkuwcc7 140 11 production production NN cord-287123-ldkuwcc7 140 12 , , , cord-287123-ldkuwcc7 140 13 which which WDT cord-287123-ldkuwcc7 140 14 in in IN cord-287123-ldkuwcc7 140 15 turn turn NN cord-287123-ldkuwcc7 140 16 elicits elicit VBZ cord-287123-ldkuwcc7 140 17 further further JJ cord-287123-ldkuwcc7 140 18 LL-37 LL-37 NNP cord-287123-ldkuwcc7 140 19 release release NN cord-287123-ldkuwcc7 140 20 through through IN cord-287123-ldkuwcc7 140 21 BLT1 BLT1 NNP cord-287123-ldkuwcc7 140 22 ( ( -LRB- cord-287123-ldkuwcc7 140 23 leukotriene leukotriene NN cord-287123-ldkuwcc7 140 24 B4 B4 NNP cord-287123-ldkuwcc7 140 25 receptor receptor NN cord-287123-ldkuwcc7 140 26 1 1 CD cord-287123-ldkuwcc7 140 27 ) ) -RRB- cord-287123-ldkuwcc7 140 28 [ [ -LRB- cord-287123-ldkuwcc7 140 29 133 133 CD cord-287123-ldkuwcc7 140 30 ] ] -RRB- cord-287123-ldkuwcc7 140 31 . . . cord-287123-ldkuwcc7 141 1 uPAR uPAR NNP cord-287123-ldkuwcc7 141 2 is be VBZ cord-287123-ldkuwcc7 141 3 the the DT cord-287123-ldkuwcc7 141 4 cell cell NN cord-287123-ldkuwcc7 141 5 surface surface NN cord-287123-ldkuwcc7 141 6 receptor receptor NN cord-287123-ldkuwcc7 141 7 for for IN cord-287123-ldkuwcc7 141 8 urokinase urokinase NN cord-287123-ldkuwcc7 141 9 - - HYPH cord-287123-ldkuwcc7 141 10 type type NN cord-287123-ldkuwcc7 141 11 plasminogen plasminogen NN cord-287123-ldkuwcc7 141 12 activator activator NN cord-287123-ldkuwcc7 141 13 ( ( -LRB- cord-287123-ldkuwcc7 141 14 uPA uPA NNP cord-287123-ldkuwcc7 141 15 ) ) -RRB- cord-287123-ldkuwcc7 141 16 that that WDT cord-287123-ldkuwcc7 141 17 is be VBZ cord-287123-ldkuwcc7 141 18 a a DT cord-287123-ldkuwcc7 141 19 serine serine NN cord-287123-ldkuwcc7 141 20 protease protease NN cord-287123-ldkuwcc7 141 21 involved involve VBN cord-287123-ldkuwcc7 141 22 in in IN cord-287123-ldkuwcc7 141 23 regulation regulation NN cord-287123-ldkuwcc7 141 24 of of IN cord-287123-ldkuwcc7 141 25 fibrinolysis fibrinolysis NN cord-287123-ldkuwcc7 141 26 , , , cord-287123-ldkuwcc7 141 27 cell cell NN cord-287123-ldkuwcc7 141 28 adhesion adhesion NN cord-287123-ldkuwcc7 141 29 , , , cord-287123-ldkuwcc7 141 30 migration migration NN cord-287123-ldkuwcc7 141 31 and and CC cord-287123-ldkuwcc7 141 32 tissue tissue NN cord-287123-ldkuwcc7 141 33 repair repair NN cord-287123-ldkuwcc7 141 34 . . . cord-287123-ldkuwcc7 142 1 uPAR uPAR NNP cord-287123-ldkuwcc7 142 2 can can MD cord-287123-ldkuwcc7 142 3 be be VB cord-287123-ldkuwcc7 142 4 cleaved cleave VBN cord-287123-ldkuwcc7 142 5 by by IN cord-287123-ldkuwcc7 142 6 different different JJ cord-287123-ldkuwcc7 142 7 proteases protease NNS cord-287123-ldkuwcc7 142 8 , , , cord-287123-ldkuwcc7 142 9 including include VBG cord-287123-ldkuwcc7 142 10 uPA upa NN cord-287123-ldkuwcc7 142 11 , , , cord-287123-ldkuwcc7 142 12 generating generate VBG cord-287123-ldkuwcc7 142 13 soluble soluble JJ cord-287123-ldkuwcc7 142 14 uPAR upar JJ cord-287123-ldkuwcc7 142 15 fragments fragment NNS cord-287123-ldkuwcc7 142 16 that that WDT cord-287123-ldkuwcc7 142 17 can can MD cord-287123-ldkuwcc7 142 18 be be VB cord-287123-ldkuwcc7 142 19 recognized recognize VBN cord-287123-ldkuwcc7 142 20 by by IN cord-287123-ldkuwcc7 142 21 different different JJ cord-287123-ldkuwcc7 142 22 FPR fpr NN cord-287123-ldkuwcc7 142 23 members member NNS cord-287123-ldkuwcc7 142 24 . . . cord-287123-ldkuwcc7 143 1 For for IN cord-287123-ldkuwcc7 143 2 instance instance NN cord-287123-ldkuwcc7 143 3 , , , cord-287123-ldkuwcc7 143 4 uPAR uPAR NNP cord-287123-ldkuwcc7 143 5 D2D3 D2D3 NNP cord-287123-ldkuwcc7 143 6 88 88 CD cord-287123-ldkuwcc7 143 7 - - SYM cord-287123-ldkuwcc7 143 8 274 274 CD cord-287123-ldkuwcc7 143 9 , , , cord-287123-ldkuwcc7 143 10 a a DT cord-287123-ldkuwcc7 143 11 cleaved cleave VBN cord-287123-ldkuwcc7 143 12 peptide peptide NN cord-287123-ldkuwcc7 143 13 corresponding correspond VBG cord-287123-ldkuwcc7 143 14 to to IN cord-287123-ldkuwcc7 143 15 residues residue NNS cord-287123-ldkuwcc7 143 16 from from IN cord-287123-ldkuwcc7 143 17 88 88 CD cord-287123-ldkuwcc7 143 18 to to IN cord-287123-ldkuwcc7 143 19 274 274 CD cord-287123-ldkuwcc7 143 20 of of IN cord-287123-ldkuwcc7 143 21 uPAR upar NN cord-287123-ldkuwcc7 143 22 , , , cord-287123-ldkuwcc7 143 23 binds bind VBZ cord-287123-ldkuwcc7 143 24 to to IN cord-287123-ldkuwcc7 143 25 and and CC cord-287123-ldkuwcc7 143 26 activates activate VBZ cord-287123-ldkuwcc7 143 27 FPR2 FPR2 NNP cord-287123-ldkuwcc7 143 28 in in IN cord-287123-ldkuwcc7 143 29 monocytes monocyte NNS cord-287123-ldkuwcc7 143 30 , , , cord-287123-ldkuwcc7 143 31 inducing induce VBG cord-287123-ldkuwcc7 143 32 cell cell NN cord-287123-ldkuwcc7 143 33 migration migration NN cord-287123-ldkuwcc7 143 34 [ [ -LRB- cord-287123-ldkuwcc7 143 35 134 134 CD cord-287123-ldkuwcc7 143 36 ] ] -RRB- cord-287123-ldkuwcc7 143 37 . . . cord-287123-ldkuwcc7 144 1 Moreover moreover RB cord-287123-ldkuwcc7 144 2 , , , cord-287123-ldkuwcc7 144 3 uPAR upar JJ cord-287123-ldkuwcc7 144 4 88 88 CD cord-287123-ldkuwcc7 144 5 - - HYPH cord-287123-ldkuwcc7 144 6 95 95 CD cord-287123-ldkuwcc7 144 7 ( ( -LRB- cord-287123-ldkuwcc7 144 8 88 88 CD cord-287123-ldkuwcc7 144 9 SRSRY SRSRY NNP cord-287123-ldkuwcc7 144 10 95 95 CD cord-287123-ldkuwcc7 144 11 ) ) -RRB- cord-287123-ldkuwcc7 144 12 interacts interact VBZ cord-287123-ldkuwcc7 144 13 with with IN cord-287123-ldkuwcc7 144 14 FPR1 FPR1 NNP cord-287123-ldkuwcc7 144 15 [ [ -LRB- cord-287123-ldkuwcc7 144 16 62 62 CD cord-287123-ldkuwcc7 144 17 ] ] -RRB- cord-287123-ldkuwcc7 144 18 , , , cord-287123-ldkuwcc7 144 19 while while IN cord-287123-ldkuwcc7 144 20 uPAR upar JJ cord-287123-ldkuwcc7 144 21 [ [ -LRB- cord-287123-ldkuwcc7 144 22 84 84 CD cord-287123-ldkuwcc7 144 23 ] ] -RRB- cord-287123-ldkuwcc7 144 24 [ [ -LRB- cord-287123-ldkuwcc7 144 25 85 85 CD cord-287123-ldkuwcc7 144 26 ] ] -RRB- cord-287123-ldkuwcc7 144 27 [ [ -LRB- cord-287123-ldkuwcc7 144 28 86 86 CD cord-287123-ldkuwcc7 144 29 ] ] -RRB- cord-287123-ldkuwcc7 144 30 [ [ -LRB- cord-287123-ldkuwcc7 144 31 87 87 CD cord-287123-ldkuwcc7 144 32 ] ] -RRB- cord-287123-ldkuwcc7 144 33 [ [ -LRB- cord-287123-ldkuwcc7 144 34 88 88 CD cord-287123-ldkuwcc7 144 35 ] ] -RRB- cord-287123-ldkuwcc7 144 36 [ [ -LRB- cord-287123-ldkuwcc7 144 37 89 89 CD cord-287123-ldkuwcc7 144 38 ] ] -RRB- cord-287123-ldkuwcc7 144 39 [ [ -LRB- cord-287123-ldkuwcc7 144 40 90 90 CD cord-287123-ldkuwcc7 144 41 ] ] -RRB- cord-287123-ldkuwcc7 144 42 [ [ -LRB- cord-287123-ldkuwcc7 144 43 91 91 CD cord-287123-ldkuwcc7 144 44 ] ] -RRB- cord-287123-ldkuwcc7 144 45 [ [ -LRB- cord-287123-ldkuwcc7 144 46 92 92 CD cord-287123-ldkuwcc7 144 47 ] ] -RRB- cord-287123-ldkuwcc7 145 1 [ [ -LRB- cord-287123-ldkuwcc7 145 2 93 93 CD cord-287123-ldkuwcc7 145 3 ] ] -RRB- cord-287123-ldkuwcc7 146 1 [ [ -LRB- cord-287123-ldkuwcc7 146 2 94 94 CD cord-287123-ldkuwcc7 146 3 ] ] -RRB- cord-287123-ldkuwcc7 147 1 [ [ -LRB- cord-287123-ldkuwcc7 147 2 95 95 CD cord-287123-ldkuwcc7 147 3 ] ] -RRB- cord-287123-ldkuwcc7 147 4 activates activate VBZ cord-287123-ldkuwcc7 147 5 both both DT cord-287123-ldkuwcc7 147 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 147 7 and and CC cord-287123-ldkuwcc7 147 8 FPR3 FPR3 NNP cord-287123-ldkuwcc7 147 9 in in IN cord-287123-ldkuwcc7 147 10 basophils basophil NNS cord-287123-ldkuwcc7 147 11 [ [ -LRB- cord-287123-ldkuwcc7 147 12 63 63 CD cord-287123-ldkuwcc7 147 13 ] ] -RRB- cord-287123-ldkuwcc7 147 14 . . . cord-287123-ldkuwcc7 148 1 In in IN cord-287123-ldkuwcc7 148 2 a a DT cord-287123-ldkuwcc7 148 3 more more RBR cord-287123-ldkuwcc7 148 4 recent recent JJ cord-287123-ldkuwcc7 148 5 study study NN cord-287123-ldkuwcc7 148 6 , , , cord-287123-ldkuwcc7 148 7 a a DT cord-287123-ldkuwcc7 148 8 new new JJ cord-287123-ldkuwcc7 148 9 host host NN cord-287123-ldkuwcc7 148 10 - - HYPH cord-287123-ldkuwcc7 148 11 derived derive VBN cord-287123-ldkuwcc7 148 12 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 148 13 agonist agonist NN cord-287123-ldkuwcc7 148 14 FAM3D fam3d NN cord-287123-ldkuwcc7 148 15 , , , cord-287123-ldkuwcc7 148 16 for for IN cord-287123-ldkuwcc7 148 17 the the DT cord-287123-ldkuwcc7 148 18 FPR1 FPR1 NNP cord-287123-ldkuwcc7 148 19 and and CC cord-287123-ldkuwcc7 148 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 148 21 was be VBD cord-287123-ldkuwcc7 148 22 identified identify VBN cord-287123-ldkuwcc7 148 23 [ [ -LRB- cord-287123-ldkuwcc7 148 24 135 135 CD cord-287123-ldkuwcc7 148 25 ] ] -RRB- cord-287123-ldkuwcc7 148 26 . . . cord-287123-ldkuwcc7 149 1 FAM3D FAM3D NNP cord-287123-ldkuwcc7 149 2 , , , cord-287123-ldkuwcc7 149 3 a a DT cord-287123-ldkuwcc7 149 4 cytokine cytokine NN cord-287123-ldkuwcc7 149 5 - - HYPH cord-287123-ldkuwcc7 149 6 like like JJ cord-287123-ldkuwcc7 149 7 protein protein NN cord-287123-ldkuwcc7 149 8 , , , cord-287123-ldkuwcc7 149 9 is be VBZ cord-287123-ldkuwcc7 149 10 constitutively constitutively RB cord-287123-ldkuwcc7 149 11 expressed express VBN cord-287123-ldkuwcc7 149 12 in in IN cord-287123-ldkuwcc7 149 13 the the DT cord-287123-ldkuwcc7 149 14 gastrointestinal gastrointestinal JJ cord-287123-ldkuwcc7 149 15 tract tract NN cord-287123-ldkuwcc7 149 16 with with IN cord-287123-ldkuwcc7 149 17 significant significant JJ cord-287123-ldkuwcc7 149 18 induction induction NN cord-287123-ldkuwcc7 149 19 in in IN cord-287123-ldkuwcc7 149 20 dextran dextran NN cord-287123-ldkuwcc7 149 21 sulfate sulfate NN cord-287123-ldkuwcc7 149 22 sodium sodium NN cord-287123-ldkuwcc7 149 23 ( ( -LRB- cord-287123-ldkuwcc7 149 24 DSS)-induced dss)-induce VBN cord-287123-ldkuwcc7 149 25 colitis colitis NN cord-287123-ldkuwcc7 149 26 [ [ -LRB- cord-287123-ldkuwcc7 149 27 135 135 CD cord-287123-ldkuwcc7 149 28 ] ] -RRB- cord-287123-ldkuwcc7 149 29 . . . cord-287123-ldkuwcc7 150 1 FAM3D FAM3D NNP cord-287123-ldkuwcc7 150 2 was be VBD cord-287123-ldkuwcc7 150 3 found find VBN cord-287123-ldkuwcc7 150 4 to to TO cord-287123-ldkuwcc7 150 5 strongly strongly RB cord-287123-ldkuwcc7 150 6 attract attract VB cord-287123-ldkuwcc7 150 7 the the DT cord-287123-ldkuwcc7 150 8 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 150 9 of of IN cord-287123-ldkuwcc7 150 10 human human JJ cord-287123-ldkuwcc7 150 11 peripheral peripheral JJ cord-287123-ldkuwcc7 150 12 blood blood NN cord-287123-ldkuwcc7 150 13 neutrophils neutrophil NNS cord-287123-ldkuwcc7 150 14 and and CC cord-287123-ldkuwcc7 150 15 monocytes monocyte NNS cord-287123-ldkuwcc7 150 16 . . . cord-287123-ldkuwcc7 151 1 Through through IN cord-287123-ldkuwcc7 151 2 functional functional JJ cord-287123-ldkuwcc7 151 3 screen screen NN cord-287123-ldkuwcc7 151 4 of of IN cord-287123-ldkuwcc7 151 5 a a DT cord-287123-ldkuwcc7 151 6 group group NN cord-287123-ldkuwcc7 151 7 of of IN cord-287123-ldkuwcc7 151 8 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 151 9 receptors receptor NNS cord-287123-ldkuwcc7 151 10 , , , cord-287123-ldkuwcc7 151 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 151 12 and and CC cord-287123-ldkuwcc7 151 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 151 14 were be VBD cord-287123-ldkuwcc7 151 15 determined determined JJ cord-287123-ldkuwcc7 151 16 to to TO cord-287123-ldkuwcc7 151 17 be be VB cord-287123-ldkuwcc7 151 18 the the DT cord-287123-ldkuwcc7 151 19 receptors receptor NNS cord-287123-ldkuwcc7 151 20 for for IN cord-287123-ldkuwcc7 151 21 FAM3D. FAM3D. NNS cord-287123-ldkuwcc7 152 1 In in IN cord-287123-ldkuwcc7 152 2 HEK293 HEK293 NNP cord-287123-ldkuwcc7 152 3 cells cell NNS cord-287123-ldkuwcc7 152 4 transfected transfecte VBN cord-287123-ldkuwcc7 152 5 to to TO cord-287123-ldkuwcc7 152 6 express express VB cord-287123-ldkuwcc7 152 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 152 8 or or CC cord-287123-ldkuwcc7 152 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 152 10 , , , cord-287123-ldkuwcc7 152 11 FAM3D fam3d NN cord-287123-ldkuwcc7 152 12 induced induce VBN cord-287123-ldkuwcc7 152 13 significant significant JJ cord-287123-ldkuwcc7 152 14 cell cell NN cord-287123-ldkuwcc7 152 15 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 152 16 and and CC cord-287123-ldkuwcc7 152 17 calcium calcium NN cord-287123-ldkuwcc7 152 18 mobilization mobilization NN cord-287123-ldkuwcc7 152 19 that that WDT cord-287123-ldkuwcc7 152 20 was be VBD cord-287123-ldkuwcc7 152 21 desensitized desensitize VBN cord-287123-ldkuwcc7 152 22 by by IN cord-287123-ldkuwcc7 152 23 other other JJ cord-287123-ldkuwcc7 152 24 FPR FPR NNP cord-287123-ldkuwcc7 152 25 agonists agonist NNS cord-287123-ldkuwcc7 152 26 ( ( -LRB- cord-287123-ldkuwcc7 152 27 fMLF fMLF NNP cord-287123-ldkuwcc7 152 28 and and CC cord-287123-ldkuwcc7 152 29 WKYMVm WKYMVm NNP cord-287123-ldkuwcc7 152 30 ) ) -RRB- cord-287123-ldkuwcc7 152 31 , , , cord-287123-ldkuwcc7 152 32 and and CC cord-287123-ldkuwcc7 152 33 vice vice NN cord-287123-ldkuwcc7 152 34 versa versa RB cord-287123-ldkuwcc7 152 35 . . . cord-287123-ldkuwcc7 153 1 The the DT cord-287123-ldkuwcc7 153 2 activation activation NN cord-287123-ldkuwcc7 153 3 of of IN cord-287123-ldkuwcc7 153 4 ERK1/2 ERK1/2 NNP cord-287123-ldkuwcc7 153 5 and and CC cord-287123-ldkuwcc7 153 6 p38 p38 CD cord-287123-ldkuwcc7 153 7 MAPK MAPK NNP cord-287123-ldkuwcc7 153 8 signaling signal VBG cord-287123-ldkuwcc7 153 9 caused cause VBN cord-287123-ldkuwcc7 153 10 by by IN cord-287123-ldkuwcc7 153 11 FAM3D fam3d CD cord-287123-ldkuwcc7 153 12 in in IN cord-287123-ldkuwcc7 153 13 neutrophils neutrophil NNS cord-287123-ldkuwcc7 153 14 was be VBD cord-287123-ldkuwcc7 153 15 blocked block VBN cord-287123-ldkuwcc7 153 16 by by IN cord-287123-ldkuwcc7 153 17 an an DT cord-287123-ldkuwcc7 153 18 antagonist antagonist NN cord-287123-ldkuwcc7 153 19 of of IN cord-287123-ldkuwcc7 153 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 153 21 ( ( -LRB- cord-287123-ldkuwcc7 153 22 WRW WRW NNP cord-287123-ldkuwcc7 153 23 4 4 CD cord-287123-ldkuwcc7 153 24 ) ) -RRB- cord-287123-ldkuwcc7 153 25 . . . cord-287123-ldkuwcc7 154 1 This this DT cord-287123-ldkuwcc7 154 2 study study NN cord-287123-ldkuwcc7 154 3 suggested suggest VBD cord-287123-ldkuwcc7 154 4 that that IN cord-287123-ldkuwcc7 154 5 FAM3D fam3d CD cord-287123-ldkuwcc7 154 6 / / SYM cord-287123-ldkuwcc7 154 7 FPR fpr NN cord-287123-ldkuwcc7 154 8 interaction interaction NN cord-287123-ldkuwcc7 154 9 might may MD cord-287123-ldkuwcc7 154 10 play play VB cord-287123-ldkuwcc7 154 11 a a DT cord-287123-ldkuwcc7 154 12 role role NN cord-287123-ldkuwcc7 154 13 in in IN cord-287123-ldkuwcc7 154 14 intestinal intestinal JJ cord-287123-ldkuwcc7 154 15 homeostasis homeostasis NN cord-287123-ldkuwcc7 154 16 and and CC cord-287123-ldkuwcc7 154 17 gastrointestinal gastrointestinal JJ cord-287123-ldkuwcc7 154 18 inflammation inflammation NN cord-287123-ldkuwcc7 154 19 . . . cord-287123-ldkuwcc7 155 1 The the DT cord-287123-ldkuwcc7 155 2 FPR FPR NNP cord-287123-ldkuwcc7 155 3 receptors receptor NNS cord-287123-ldkuwcc7 155 4 also also RB cord-287123-ldkuwcc7 155 5 have have VBP cord-287123-ldkuwcc7 155 6 other other JJ cord-287123-ldkuwcc7 155 7 endogenous endogenous JJ cord-287123-ldkuwcc7 155 8 peptide peptide NN cord-287123-ldkuwcc7 155 9 ligands ligand NNS cord-287123-ldkuwcc7 155 10 , , , cord-287123-ldkuwcc7 155 11 such such JJ cord-287123-ldkuwcc7 155 12 as as IN cord-287123-ldkuwcc7 155 13 cathepsin cathepsin NN cord-287123-ldkuwcc7 155 14 G g NN cord-287123-ldkuwcc7 155 15 for for IN cord-287123-ldkuwcc7 155 16 FPR1 FPR1 NNP cord-287123-ldkuwcc7 155 17 , , , cord-287123-ldkuwcc7 155 18 chemokine chemokine NN cord-287123-ldkuwcc7 155 19 CCL23 CCL23 NNP cord-287123-ldkuwcc7 155 20 ( ( -LRB- cord-287123-ldkuwcc7 155 21 amino amino NN cord-287123-ldkuwcc7 155 22 acids acid NNS cord-287123-ldkuwcc7 155 23 and and CC cord-287123-ldkuwcc7 155 24 its -PRON- PRP$ cord-287123-ldkuwcc7 155 25 N n CD cord-287123-ldkuwcc7 155 26 - - HYPH cord-287123-ldkuwcc7 155 27 terminal terminal NN cord-287123-ldkuwcc7 155 28 fragment fragment NN cord-287123-ldkuwcc7 155 29 SHAAGtide shaagtide NN cord-287123-ldkuwcc7 155 30 for for IN cord-287123-ldkuwcc7 155 31 FPR2 FPR2 NNP cord-287123-ldkuwcc7 155 32 , , , cord-287123-ldkuwcc7 155 33 a a DT cord-287123-ldkuwcc7 155 34 vasoactive vasoactive JJ cord-287123-ldkuwcc7 155 35 intestinal intestinal JJ cord-287123-ldkuwcc7 155 36 neuropeptide neuropeptide NN cord-287123-ldkuwcc7 155 37 VIP vip NN cord-287123-ldkuwcc7 155 38 ( ( -LRB- cord-287123-ldkuwcc7 155 39 vasoactive vasoactive JJ cord-287123-ldkuwcc7 155 40 intestinal intestinal JJ cord-287123-ldkuwcc7 155 41 polypeptide polypeptide NN cord-287123-ldkuwcc7 155 42 ) ) -RRB- cord-287123-ldkuwcc7 155 43 for for IN cord-287123-ldkuwcc7 155 44 FPR2 FPR2 NNP cord-287123-ldkuwcc7 155 45 , , , cord-287123-ldkuwcc7 155 46 and and CC cord-287123-ldkuwcc7 155 47 a a DT cord-287123-ldkuwcc7 155 48 heme heme NN cord-287123-ldkuwcc7 155 49 - - HYPH cord-287123-ldkuwcc7 155 50 binding bind VBG cord-287123-ldkuwcc7 155 51 protein protein NN cord-287123-ldkuwcc7 155 52 fragment fragment NN cord-287123-ldkuwcc7 155 53 F2L f2l NN cord-287123-ldkuwcc7 155 54 for for IN cord-287123-ldkuwcc7 155 55 FPR3 FPR3 NNP cord-287123-ldkuwcc7 155 56 ( ( -LRB- cord-287123-ldkuwcc7 155 57 Table Table NNP cord-287123-ldkuwcc7 155 58 1 1 CD cord-287123-ldkuwcc7 155 59 ) ) -RRB- cord-287123-ldkuwcc7 155 60 . . . cord-287123-ldkuwcc7 156 1 In in IN cord-287123-ldkuwcc7 156 2 addition addition NN cord-287123-ldkuwcc7 156 3 , , , cord-287123-ldkuwcc7 156 4 exogenous exogenous JJ cord-287123-ldkuwcc7 156 5 allergens allergen NNS cord-287123-ldkuwcc7 156 6 including include VBG cord-287123-ldkuwcc7 156 7 house house NN cord-287123-ldkuwcc7 156 8 dust dust NN cord-287123-ldkuwcc7 156 9 mite mite NNP cord-287123-ldkuwcc7 156 10 and and CC cord-287123-ldkuwcc7 156 11 birch birch NN cord-287123-ldkuwcc7 156 12 pollen pollen NN cord-287123-ldkuwcc7 156 13 extracts extract NNS cord-287123-ldkuwcc7 156 14 were be VBD cord-287123-ldkuwcc7 156 15 recently recently RB cord-287123-ldkuwcc7 156 16 shown show VBN cord-287123-ldkuwcc7 156 17 as as IN cord-287123-ldkuwcc7 156 18 being be VBG cord-287123-ldkuwcc7 156 19 agonistic agonistic JJ cord-287123-ldkuwcc7 156 20 for for IN cord-287123-ldkuwcc7 156 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 156 22 and and CC cord-287123-ldkuwcc7 156 23 FPR2 FPR2 NNP cord-287123-ldkuwcc7 156 24 . . . cord-287123-ldkuwcc7 157 1 The the DT cord-287123-ldkuwcc7 157 2 detailed detailed JJ cord-287123-ldkuwcc7 157 3 properties property NNS cord-287123-ldkuwcc7 157 4 of of IN cord-287123-ldkuwcc7 157 5 these these DT cord-287123-ldkuwcc7 157 6 FPR FPR NNP cord-287123-ldkuwcc7 157 7 agonists agonist NNS cord-287123-ldkuwcc7 157 8 are be VBP cord-287123-ldkuwcc7 157 9 discussed discuss VBN cord-287123-ldkuwcc7 157 10 in in IN cord-287123-ldkuwcc7 157 11 previous previous JJ cord-287123-ldkuwcc7 157 12 reviews review NNS cord-287123-ldkuwcc7 157 13 [ [ -LRB- cord-287123-ldkuwcc7 157 14 2 2 CD cord-287123-ldkuwcc7 157 15 , , , cord-287123-ldkuwcc7 157 16 5 5 CD cord-287123-ldkuwcc7 157 17 , , , cord-287123-ldkuwcc7 157 18 136 136 CD cord-287123-ldkuwcc7 157 19 ] ] -RRB- cord-287123-ldkuwcc7 157 20 . . . cord-287123-ldkuwcc7 158 1 Among among IN cord-287123-ldkuwcc7 158 2 all all PDT cord-287123-ldkuwcc7 158 3 the the DT cord-287123-ldkuwcc7 158 4 synthetic synthetic JJ cord-287123-ldkuwcc7 158 5 peptide peptide NN cord-287123-ldkuwcc7 158 6 agonists agonist NNS cord-287123-ldkuwcc7 158 7 for for IN cord-287123-ldkuwcc7 158 8 FPRs fpr NNS cord-287123-ldkuwcc7 158 9 , , , cord-287123-ldkuwcc7 158 10 a a DT cord-287123-ldkuwcc7 158 11 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 158 12 , , , cord-287123-ldkuwcc7 158 13 Trp Trp NNP cord-287123-ldkuwcc7 158 14 - - HYPH cord-287123-ldkuwcc7 158 15 Lys Lys NNP cord-287123-ldkuwcc7 158 16 - - HYPH cord-287123-ldkuwcc7 158 17 Tyr Tyr NNP cord-287123-ldkuwcc7 158 18 - - HYPH cord-287123-ldkuwcc7 158 19 Met Met NNP cord-287123-ldkuwcc7 158 20 - - HYPH cord-287123-ldkuwcc7 158 21 Val Val NNP cord-287123-ldkuwcc7 158 22 - - HYPH cord-287123-ldkuwcc7 158 23 D D NNP cord-287123-ldkuwcc7 158 24 - - HYPH cord-287123-ldkuwcc7 158 25 Met Met NNP cord-287123-ldkuwcc7 158 26 - - HYPH cord-287123-ldkuwcc7 158 27 NH NH NNP cord-287123-ldkuwcc7 158 28 2 2 CD cord-287123-ldkuwcc7 158 29 ( ( -LRB- cord-287123-ldkuwcc7 158 30 WKYMVm WKYMVm NNP cord-287123-ldkuwcc7 158 31 ) ) -RRB- cord-287123-ldkuwcc7 158 32 isolated isolate VBN cord-287123-ldkuwcc7 158 33 from from IN cord-287123-ldkuwcc7 158 34 a a DT cord-287123-ldkuwcc7 158 35 random random JJ cord-287123-ldkuwcc7 158 36 peptide peptide NN cord-287123-ldkuwcc7 158 37 library library NN cord-287123-ldkuwcc7 158 38 [ [ -LRB- cord-287123-ldkuwcc7 158 39 67 67 CD cord-287123-ldkuwcc7 158 40 ] ] -RRB- cord-287123-ldkuwcc7 158 41 , , , cord-287123-ldkuwcc7 158 42 was be VBD cord-287123-ldkuwcc7 158 43 identified identify VBN cord-287123-ldkuwcc7 158 44 to to TO cord-287123-ldkuwcc7 158 45 be be VB cord-287123-ldkuwcc7 158 46 a a DT cord-287123-ldkuwcc7 158 47 strong strong JJ cord-287123-ldkuwcc7 158 48 activator activator NN cord-287123-ldkuwcc7 158 49 for for IN cord-287123-ldkuwcc7 158 50 FPR1 FPR1 NNP cord-287123-ldkuwcc7 158 51 , , , cord-287123-ldkuwcc7 158 52 FPR2 FPR2 NNP cord-287123-ldkuwcc7 158 53 and and CC cord-287123-ldkuwcc7 158 54 FPR3 FPR3 NNP cord-287123-ldkuwcc7 158 55 [ [ -LRB- cord-287123-ldkuwcc7 158 56 68 68 CD cord-287123-ldkuwcc7 158 57 , , , cord-287123-ldkuwcc7 158 58 137 137 CD cord-287123-ldkuwcc7 158 59 ] ] -RRB- cord-287123-ldkuwcc7 158 60 . . . cord-287123-ldkuwcc7 159 1 WKYMVm WKYMVm NNS cord-287123-ldkuwcc7 159 2 conjugated conjugate VBD cord-287123-ldkuwcc7 159 3 with with IN cord-287123-ldkuwcc7 159 4 FITC FITC NNP cord-287123-ldkuwcc7 159 5 in in IN cord-287123-ldkuwcc7 159 6 the the DT cord-287123-ldkuwcc7 159 7 second second JJ cord-287123-ldkuwcc7 159 8 residue residue NN cord-287123-ldkuwcc7 159 9 Lys Lys NNP cord-287123-ldkuwcc7 159 10 was be VBD cord-287123-ldkuwcc7 159 11 shown show VBN cord-287123-ldkuwcc7 159 12 slightly slightly RB cord-287123-ldkuwcc7 159 13 more more RBR cord-287123-ldkuwcc7 159 14 efficacious efficacious JJ cord-287123-ldkuwcc7 159 15 in in IN cord-287123-ldkuwcc7 159 16 binding bind VBG cord-287123-ldkuwcc7 159 17 to to IN cord-287123-ldkuwcc7 159 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 159 19 than than IN cord-287123-ldkuwcc7 159 20 to to IN cord-287123-ldkuwcc7 159 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 159 22 [ [ -LRB- cord-287123-ldkuwcc7 159 23 96 96 CD cord-287123-ldkuwcc7 159 24 ] ] -RRB- cord-287123-ldkuwcc7 159 25 . . . cord-287123-ldkuwcc7 160 1 WKYMVm WKYMVm NNP cord-287123-ldkuwcc7 160 2 is be VBZ cord-287123-ldkuwcc7 160 3 by by IN cord-287123-ldkuwcc7 160 4 far far RB cord-287123-ldkuwcc7 160 5 the the DT cord-287123-ldkuwcc7 160 6 most most RBS cord-287123-ldkuwcc7 160 7 potent potent JJ cord-287123-ldkuwcc7 160 8 peptide peptide NN cord-287123-ldkuwcc7 160 9 agonist agonist NN cord-287123-ldkuwcc7 160 10 for for IN cord-287123-ldkuwcc7 160 11 FPR2 FPR2 NNP cord-287123-ldkuwcc7 160 12 , , , cord-287123-ldkuwcc7 160 13 being be VBG cord-287123-ldkuwcc7 160 14 able able JJ cord-287123-ldkuwcc7 160 15 to to TO cord-287123-ldkuwcc7 160 16 activate activate VB cord-287123-ldkuwcc7 160 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 160 18 at at IN cord-287123-ldkuwcc7 160 19 picomolar picomolar JJ cord-287123-ldkuwcc7 160 20 concentrations concentration NNS cord-287123-ldkuwcc7 160 21 in in IN cord-287123-ldkuwcc7 160 22 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 160 23 assays assay NNS cord-287123-ldkuwcc7 160 24 . . . cord-287123-ldkuwcc7 161 1 WKYMVM WKYMVM NNP cord-287123-ldkuwcc7 161 2 , , , cord-287123-ldkuwcc7 161 3 a a DT cord-287123-ldkuwcc7 161 4 derivative derivative NN cord-287123-ldkuwcc7 161 5 of of IN cord-287123-ldkuwcc7 161 6 WKYMVm WKYMVm NNS cord-287123-ldkuwcc7 161 7 with with IN cord-287123-ldkuwcc7 161 8 the the DT cord-287123-ldkuwcc7 161 9 substitution substitution NN cord-287123-ldkuwcc7 161 10 of of IN cord-287123-ldkuwcc7 161 11 L l NN cord-287123-ldkuwcc7 161 12 - - HYPH cord-287123-ldkuwcc7 161 13 methionine methionine NN cord-287123-ldkuwcc7 161 14 at at IN cord-287123-ldkuwcc7 161 15 the the DT cord-287123-ldkuwcc7 161 16 carboxyl carboxyl NN cord-287123-ldkuwcc7 161 17 terminus terminus NN cord-287123-ldkuwcc7 161 18 , , , cord-287123-ldkuwcc7 161 19 becomes become VBZ cord-287123-ldkuwcc7 161 20 highly highly RB cord-287123-ldkuwcc7 161 21 selective selective JJ cord-287123-ldkuwcc7 161 22 for for IN cord-287123-ldkuwcc7 161 23 FPR2 FPR2 NNP cord-287123-ldkuwcc7 161 24 and and CC cord-287123-ldkuwcc7 161 25 is be VBZ cord-287123-ldkuwcc7 161 26 weakly weakly RB cord-287123-ldkuwcc7 161 27 agonistic agonistic JJ cord-287123-ldkuwcc7 161 28 for for IN cord-287123-ldkuwcc7 161 29 FPR3 FPR3 NNP cord-287123-ldkuwcc7 161 30 [ [ -LRB- cord-287123-ldkuwcc7 161 31 69 69 CD cord-287123-ldkuwcc7 161 32 ] ] -RRB- cord-287123-ldkuwcc7 161 33 . . . cord-287123-ldkuwcc7 162 1 Another another DT cord-287123-ldkuwcc7 162 2 peptide peptide NN cord-287123-ldkuwcc7 162 3 identified identify VBD cord-287123-ldkuwcc7 162 4 from from IN cord-287123-ldkuwcc7 162 5 library library NN cord-287123-ldkuwcc7 162 6 screen screen NN cord-287123-ldkuwcc7 162 7 , , , cord-287123-ldkuwcc7 162 8 MMK-1 MMK-1 NNP cord-287123-ldkuwcc7 162 9 ( ( -LRB- cord-287123-ldkuwcc7 162 10 LESIFRSLLFRVM LESIFRSLLFRVM NNP cord-287123-ldkuwcc7 162 11 ) ) -RRB- cord-287123-ldkuwcc7 162 12 , , , cord-287123-ldkuwcc7 162 13 is be VBZ cord-287123-ldkuwcc7 162 14 a a DT cord-287123-ldkuwcc7 162 15 highly highly RB cord-287123-ldkuwcc7 162 16 selective selective JJ cord-287123-ldkuwcc7 162 17 chemotactic chemotactic JJ cord-287123-ldkuwcc7 162 18 agonist agonist NN cord-287123-ldkuwcc7 162 19 for for IN cord-287123-ldkuwcc7 162 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 162 21 [ [ -LRB- cord-287123-ldkuwcc7 162 22 70 70 CD cord-287123-ldkuwcc7 162 23 , , , cord-287123-ldkuwcc7 162 24 138 138 CD cord-287123-ldkuwcc7 162 25 ] ] -RRB- cord-287123-ldkuwcc7 162 26 . . . cord-287123-ldkuwcc7 163 1 CGEN-855A CGEN-855A NNP cord-287123-ldkuwcc7 163 2 , , , cord-287123-ldkuwcc7 163 3 a a DT cord-287123-ldkuwcc7 163 4 21 21 CD cord-287123-ldkuwcc7 163 5 amino amino NN cord-287123-ldkuwcc7 163 6 acids acid NNS cord-287123-ldkuwcc7 163 7 anti anti JJ cord-287123-ldkuwcc7 163 8 - - JJ cord-287123-ldkuwcc7 163 9 inflammatory inflammatory JJ cord-287123-ldkuwcc7 163 10 peptide peptide NN cord-287123-ldkuwcc7 163 11 obtained obtain VBN cord-287123-ldkuwcc7 163 12 from from IN cord-287123-ldkuwcc7 163 13 a a DT cord-287123-ldkuwcc7 163 14 computational computational JJ cord-287123-ldkuwcc7 163 15 platform platform NN cord-287123-ldkuwcc7 163 16 , , , cord-287123-ldkuwcc7 163 17 was be VBD cord-287123-ldkuwcc7 163 18 identified identify VBN cord-287123-ldkuwcc7 163 19 to to TO cord-287123-ldkuwcc7 163 20 be be VB cord-287123-ldkuwcc7 163 21 agonist agonist JJ cord-287123-ldkuwcc7 163 22 for for IN cord-287123-ldkuwcc7 163 23 FPR2 FPR2 NNP cord-287123-ldkuwcc7 163 24 and and CC cord-287123-ldkuwcc7 163 25 FPR3 FPR3 NNP cord-287123-ldkuwcc7 163 26 [ [ -LRB- cord-287123-ldkuwcc7 163 27 139 139 CD cord-287123-ldkuwcc7 163 28 ] ] -RRB- cord-287123-ldkuwcc7 163 29 . . . cord-287123-ldkuwcc7 164 1 In in IN cord-287123-ldkuwcc7 164 2 another another DT cord-287123-ldkuwcc7 164 3 study study NN cord-287123-ldkuwcc7 164 4 , , , cord-287123-ldkuwcc7 164 5 a a DT cord-287123-ldkuwcc7 164 6 tethered tethered JJ cord-287123-ldkuwcc7 164 7 library library NN cord-287123-ldkuwcc7 164 8 was be VBD cord-287123-ldkuwcc7 164 9 screened screen VBN cord-287123-ldkuwcc7 164 10 and and CC cord-287123-ldkuwcc7 164 11 a a DT cord-287123-ldkuwcc7 164 12 peptide peptide NN cord-287123-ldkuwcc7 164 13 with with IN cord-287123-ldkuwcc7 164 14 the the DT cord-287123-ldkuwcc7 164 15 sequence sequence NN cord-287123-ldkuwcc7 164 16 MMWLL MMWLL NNP cord-287123-ldkuwcc7 164 17 was be VBD cord-287123-ldkuwcc7 164 18 identified identify VBN cord-287123-ldkuwcc7 164 19 as as IN cord-287123-ldkuwcc7 164 20 an an DT cord-287123-ldkuwcc7 164 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 164 22 agonist agonist NN cord-287123-ldkuwcc7 164 23 [ [ -LRB- cord-287123-ldkuwcc7 164 24 140 140 CD cord-287123-ldkuwcc7 164 25 ] ] -RRB- cord-287123-ldkuwcc7 164 26 . . . cord-287123-ldkuwcc7 165 1 This this DT cord-287123-ldkuwcc7 165 2 peptide peptide NN cord-287123-ldkuwcc7 165 3 becomes become VBZ cord-287123-ldkuwcc7 165 4 1000-fold 1000-fold JJ cord-287123-ldkuwcc7 165 5 more more RBR cord-287123-ldkuwcc7 165 6 potent potent JJ cord-287123-ldkuwcc7 165 7 when when WRB cord-287123-ldkuwcc7 165 8 the the DT cord-287123-ldkuwcc7 165 9 first first JJ cord-287123-ldkuwcc7 165 10 Met Met NNP cord-287123-ldkuwcc7 165 11 is be VBZ cord-287123-ldkuwcc7 165 12 N n CD cord-287123-ldkuwcc7 165 13 - - HYPH cord-287123-ldkuwcc7 165 14 formylated formylate VBN cord-287123-ldkuwcc7 165 15 , , , cord-287123-ldkuwcc7 165 16 consistent consistent JJ cord-287123-ldkuwcc7 165 17 with with IN cord-287123-ldkuwcc7 165 18 the the DT cord-287123-ldkuwcc7 165 19 preferential preferential JJ cord-287123-ldkuwcc7 165 20 recognition recognition NN cord-287123-ldkuwcc7 165 21 of of IN cord-287123-ldkuwcc7 165 22 fMet fMet NNP cord-287123-ldkuwcc7 165 23 - - HYPH cord-287123-ldkuwcc7 165 24 containing contain VBG cord-287123-ldkuwcc7 165 25 peptides peptide NNS cord-287123-ldkuwcc7 165 26 by by IN cord-287123-ldkuwcc7 165 27 FPR1 FPR1 NNP cord-287123-ldkuwcc7 165 28 . . . cord-287123-ldkuwcc7 166 1 In in IN cord-287123-ldkuwcc7 166 2 a a DT cord-287123-ldkuwcc7 166 3 recent recent JJ cord-287123-ldkuwcc7 166 4 study study NN cord-287123-ldkuwcc7 166 5 [ [ -LRB- cord-287123-ldkuwcc7 166 6 141 141 CD cord-287123-ldkuwcc7 166 7 ] ] -RRB- cord-287123-ldkuwcc7 166 8 , , , cord-287123-ldkuwcc7 166 9 a a DT cord-287123-ldkuwcc7 166 10 series series NN cord-287123-ldkuwcc7 166 11 of of IN cord-287123-ldkuwcc7 166 12 AApeptides AApeptides NNP cord-287123-ldkuwcc7 166 13 , , , cord-287123-ldkuwcc7 166 14 a a DT cord-287123-ldkuwcc7 166 15 class class NN cord-287123-ldkuwcc7 166 16 of of IN cord-287123-ldkuwcc7 166 17 peptidomimetics peptidomimetic NNS cord-287123-ldkuwcc7 166 18 based base VBN cord-287123-ldkuwcc7 166 19 on on IN cord-287123-ldkuwcc7 166 20 N n CD cord-287123-ldkuwcc7 166 21 - - HYPH cord-287123-ldkuwcc7 166 22 acylated acylated NNP cord-287123-ldkuwcc7 166 23 - - HYPH cord-287123-ldkuwcc7 166 24 N N NNP cord-287123-ldkuwcc7 166 25 - - HYPH cord-287123-ldkuwcc7 166 26 aminoethyl aminoethyl NN cord-287123-ldkuwcc7 166 27 amino amino NN cord-287123-ldkuwcc7 166 28 acid acid NN cord-287123-ldkuwcc7 166 29 residues residue NNS cord-287123-ldkuwcc7 166 30 , , , cord-287123-ldkuwcc7 166 31 were be VBD cord-287123-ldkuwcc7 166 32 designed design VBN cord-287123-ldkuwcc7 166 33 and and CC cord-287123-ldkuwcc7 166 34 synthesized synthesize VBN cord-287123-ldkuwcc7 166 35 to to TO cord-287123-ldkuwcc7 166 36 mimic mimic VB cord-287123-ldkuwcc7 166 37 the the DT cord-287123-ldkuwcc7 166 38 structure structure NN cord-287123-ldkuwcc7 166 39 and and CC cord-287123-ldkuwcc7 166 40 function function NN cord-287123-ldkuwcc7 166 41 of of IN cord-287123-ldkuwcc7 166 42 the the DT cord-287123-ldkuwcc7 166 43 prototypic prototypic NNP cord-287123-ldkuwcc7 166 44 tripeptide tripeptide NNP cord-287123-ldkuwcc7 166 45 fMLF fMLF NNP cord-287123-ldkuwcc7 166 46 , , , cord-287123-ldkuwcc7 166 47 the the DT cord-287123-ldkuwcc7 166 48 reference reference NN cord-287123-ldkuwcc7 166 49 agonist agonist NN cord-287123-ldkuwcc7 166 50 of of IN cord-287123-ldkuwcc7 166 51 FPR1 FPR1 NNP cord-287123-ldkuwcc7 166 52 . . . cord-287123-ldkuwcc7 167 1 Three three CD cord-287123-ldkuwcc7 167 2 of of IN cord-287123-ldkuwcc7 167 3 these these DT cord-287123-ldkuwcc7 167 4 fMLF fmlf JJ cord-287123-ldkuwcc7 167 5 - - HYPH cord-287123-ldkuwcc7 167 6 mimicking mimic VBG cord-287123-ldkuwcc7 167 7 AApeptides aapeptide NNS cord-287123-ldkuwcc7 167 8 were be VBD cord-287123-ldkuwcc7 167 9 found find VBN cord-287123-ldkuwcc7 167 10 effective effective JJ cord-287123-ldkuwcc7 167 11 in in IN cord-287123-ldkuwcc7 167 12 activating activate VBG cord-287123-ldkuwcc7 167 13 FPR fpr NN cord-287123-ldkuwcc7 167 14 - - HYPH cord-287123-ldkuwcc7 167 15 expressing express VBG cord-287123-ldkuwcc7 167 16 cells cell NNS cord-287123-ldkuwcc7 167 17 in in IN cord-287123-ldkuwcc7 167 18 calcium calcium NN cord-287123-ldkuwcc7 167 19 mobilization mobilization NN cord-287123-ldkuwcc7 167 20 assay assay NN cord-287123-ldkuwcc7 167 21 , , , cord-287123-ldkuwcc7 167 22 albeit albeit IN cord-287123-ldkuwcc7 167 23 at at IN cord-287123-ldkuwcc7 167 24 concentrations concentration NNS cord-287123-ldkuwcc7 167 25 above above IN cord-287123-ldkuwcc7 167 26 10 10 CD cord-287123-ldkuwcc7 168 1 µM. µM. NNP cord-287123-ldkuwcc7 169 1 Certain certain JJ cord-287123-ldkuwcc7 169 2 AApeptides aapeptide NNS cord-287123-ldkuwcc7 169 3 were be VBD cord-287123-ldkuwcc7 169 4 shown show VBN cord-287123-ldkuwcc7 169 5 to to TO cord-287123-ldkuwcc7 169 6 be be VB cord-287123-ldkuwcc7 169 7 more more RBR cord-287123-ldkuwcc7 169 8 efficacious efficacious JJ cord-287123-ldkuwcc7 169 9 than than IN cord-287123-ldkuwcc7 169 10 fMLF fmlf NN cord-287123-ldkuwcc7 169 11 at at IN cord-287123-ldkuwcc7 169 12 a a DT cord-287123-ldkuwcc7 169 13 higher high JJR cord-287123-ldkuwcc7 169 14 concentration concentration NN cord-287123-ldkuwcc7 169 15 ( ( -LRB- cord-287123-ldkuwcc7 169 16 10 10 CD cord-287123-ldkuwcc7 169 17 µM µm NN cord-287123-ldkuwcc7 169 18 ) ) -RRB- cord-287123-ldkuwcc7 169 19 . . . cord-287123-ldkuwcc7 170 1 Similar similar JJ cord-287123-ldkuwcc7 170 2 to to IN cord-287123-ldkuwcc7 170 3 fMLF fMLF NNP cord-287123-ldkuwcc7 170 4 , , , cord-287123-ldkuwcc7 170 5 these these DT cord-287123-ldkuwcc7 170 6 AApeptides aapeptide NNS cord-287123-ldkuwcc7 170 7 have have VBP cord-287123-ldkuwcc7 170 8 receptor receptor NN cord-287123-ldkuwcc7 170 9 preference preference NN cord-287123-ldkuwcc7 170 10 for for IN cord-287123-ldkuwcc7 170 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 170 12 over over IN cord-287123-ldkuwcc7 170 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 170 14 . . . cord-287123-ldkuwcc7 171 1 In in IN cord-287123-ldkuwcc7 171 2 comparison comparison NN cord-287123-ldkuwcc7 171 3 with with IN cord-287123-ldkuwcc7 171 4 peptide peptide NN cord-287123-ldkuwcc7 171 5 / / SYM cord-287123-ldkuwcc7 171 6 protein protein NN cord-287123-ldkuwcc7 171 7 FPR FPR NNP cord-287123-ldkuwcc7 171 8 agonists agonist NNS cord-287123-ldkuwcc7 171 9 , , , cord-287123-ldkuwcc7 171 10 the the DT cord-287123-ldkuwcc7 171 11 small small JJ cord-287123-ldkuwcc7 171 12 molecule molecule NN cord-287123-ldkuwcc7 171 13 agonists agonist NNS cord-287123-ldkuwcc7 171 14 screened screen VBN cord-287123-ldkuwcc7 171 15 from from IN cord-287123-ldkuwcc7 171 16 chemical chemical JJ cord-287123-ldkuwcc7 171 17 library library NN cord-287123-ldkuwcc7 171 18 are be VBP cord-287123-ldkuwcc7 171 19 more more RBR cord-287123-ldkuwcc7 171 20 stable stable JJ cord-287123-ldkuwcc7 171 21 and and CC cord-287123-ldkuwcc7 171 22 highly highly RB cord-287123-ldkuwcc7 171 23 selective selective JJ cord-287123-ldkuwcc7 171 24 for for IN cord-287123-ldkuwcc7 171 25 certain certain JJ cord-287123-ldkuwcc7 171 26 FPR FPR NNP cord-287123-ldkuwcc7 171 27 members member NNS cord-287123-ldkuwcc7 171 28 . . . cord-287123-ldkuwcc7 172 1 These these DT cord-287123-ldkuwcc7 172 2 properties property NNS cord-287123-ldkuwcc7 172 3 make make VBP cord-287123-ldkuwcc7 172 4 them -PRON- PRP cord-287123-ldkuwcc7 172 5 valuable valuable JJ cord-287123-ldkuwcc7 172 6 tools tool NNS cord-287123-ldkuwcc7 172 7 for for IN cord-287123-ldkuwcc7 172 8 detailed detailed JJ cord-287123-ldkuwcc7 172 9 characterization characterization NN cord-287123-ldkuwcc7 172 10 of of IN cord-287123-ldkuwcc7 172 11 FPRs fpr NNS cord-287123-ldkuwcc7 172 12 , , , cord-287123-ldkuwcc7 172 13 which which WDT cord-287123-ldkuwcc7 172 14 is be VBZ cord-287123-ldkuwcc7 172 15 important important JJ cord-287123-ldkuwcc7 172 16 for for IN cord-287123-ldkuwcc7 172 17 a a DT cord-287123-ldkuwcc7 172 18 better well JJR cord-287123-ldkuwcc7 172 19 understanding understanding NN cord-287123-ldkuwcc7 172 20 of of IN cord-287123-ldkuwcc7 172 21 the the DT cord-287123-ldkuwcc7 172 22 complex complex JJ cord-287123-ldkuwcc7 172 23 role role NN cord-287123-ldkuwcc7 172 24 of of IN cord-287123-ldkuwcc7 172 25 FPRs FPRs NNP cord-287123-ldkuwcc7 172 26 in in IN cord-287123-ldkuwcc7 172 27 vivo vivo NNP cord-287123-ldkuwcc7 172 28 . . . cord-287123-ldkuwcc7 173 1 FPRs fpr NNS cord-287123-ldkuwcc7 173 2 are be VBP cord-287123-ldkuwcc7 173 3 involved involve VBN cord-287123-ldkuwcc7 173 4 in in IN cord-287123-ldkuwcc7 173 5 a a DT cord-287123-ldkuwcc7 173 6 variety variety NN cord-287123-ldkuwcc7 173 7 of of IN cord-287123-ldkuwcc7 173 8 signaling signal VBG cord-287123-ldkuwcc7 173 9 systems system NNS cord-287123-ldkuwcc7 173 10 and and CC cord-287123-ldkuwcc7 173 11 their -PRON- PRP$ cord-287123-ldkuwcc7 173 12 distribution distribution NN cord-287123-ldkuwcc7 173 13 and and CC cord-287123-ldkuwcc7 173 14 functions function NNS cord-287123-ldkuwcc7 173 15 are be VBP cord-287123-ldkuwcc7 173 16 not not RB cord-287123-ldkuwcc7 173 17 limited limited JJ cord-287123-ldkuwcc7 173 18 to to IN cord-287123-ldkuwcc7 173 19 the the DT cord-287123-ldkuwcc7 173 20 immune immune JJ cord-287123-ldkuwcc7 173 21 system system NN cord-287123-ldkuwcc7 173 22 . . . cord-287123-ldkuwcc7 174 1 As as IN cord-287123-ldkuwcc7 174 2 a a DT cord-287123-ldkuwcc7 174 3 result result NN cord-287123-ldkuwcc7 174 4 , , , cord-287123-ldkuwcc7 174 5 these these DT cord-287123-ldkuwcc7 174 6 small small JJ cord-287123-ldkuwcc7 174 7 molecules molecule NNS cord-287123-ldkuwcc7 174 8 screened screen VBN cord-287123-ldkuwcc7 174 9 by by IN cord-287123-ldkuwcc7 174 10 targeting target VBG cord-287123-ldkuwcc7 174 11 FPRs fpr NNS cord-287123-ldkuwcc7 174 12 as as IN cord-287123-ldkuwcc7 174 13 agonists agonist NNS cord-287123-ldkuwcc7 174 14 or or CC cord-287123-ldkuwcc7 174 15 antagonists antagonist NNS cord-287123-ldkuwcc7 174 16 are be VBP cord-287123-ldkuwcc7 174 17 expected expect VBN cord-287123-ldkuwcc7 174 18 to to TO cord-287123-ldkuwcc7 174 19 serve serve VB cord-287123-ldkuwcc7 174 20 as as IN cord-287123-ldkuwcc7 174 21 potentially potentially RB cord-287123-ldkuwcc7 174 22 useful useful JJ cord-287123-ldkuwcc7 174 23 agents agent NNS cord-287123-ldkuwcc7 174 24 in in IN cord-287123-ldkuwcc7 174 25 therapeutic therapeutic JJ cord-287123-ldkuwcc7 174 26 treatment treatment NN cord-287123-ldkuwcc7 174 27 . . . cord-287123-ldkuwcc7 175 1 The the DT cord-287123-ldkuwcc7 175 2 first first JJ cord-287123-ldkuwcc7 175 3 reported report VBN cord-287123-ldkuwcc7 175 4 non non JJ cord-287123-ldkuwcc7 175 5 - - JJ cord-287123-ldkuwcc7 175 6 peptide peptide JJ cord-287123-ldkuwcc7 175 7 agonist agonist NN cord-287123-ldkuwcc7 175 8 for for IN cord-287123-ldkuwcc7 175 9 FPR fpr NN cord-287123-ldkuwcc7 175 10 from from IN cord-287123-ldkuwcc7 175 11 library library NN cord-287123-ldkuwcc7 175 12 screening screening NN cord-287123-ldkuwcc7 175 13 is be VBZ cord-287123-ldkuwcc7 175 14 a a DT cord-287123-ldkuwcc7 175 15 quinazolinone quinazolinone NN cord-287123-ldkuwcc7 175 16 derivative derivative JJ cord-287123-ldkuwcc7 175 17 named name VBN cord-287123-ldkuwcc7 175 18 Quin Quin NNP cord-287123-ldkuwcc7 175 19 - - HYPH cord-287123-ldkuwcc7 175 20 C1 C1 NNP cord-287123-ldkuwcc7 175 21 [ [ -LRB- cord-287123-ldkuwcc7 175 22 75 75 CD cord-287123-ldkuwcc7 175 23 ] ] -RRB- cord-287123-ldkuwcc7 175 24 . . . cord-287123-ldkuwcc7 176 1 Quin Quin NNP cord-287123-ldkuwcc7 176 2 - - HYPH cord-287123-ldkuwcc7 176 3 C1 C1 NNP cord-287123-ldkuwcc7 176 4 ( ( -LRB- cord-287123-ldkuwcc7 176 5 4-butoxy 4-butoxy CD cord-287123-ldkuwcc7 176 6 - - : cord-287123-ldkuwcc7 176 7 N-[2-(4-methoxy n-[2-(4-methoxy NN cord-287123-ldkuwcc7 176 8 - - HYPH cord-287123-ldkuwcc7 176 9 phenyl)-4-oxo-1 phenyl)-4-oxo-1 NNP cord-287123-ldkuwcc7 176 10 , , , cord-287123-ldkuwcc7 176 11 4-dihydro-2H 4-dihydro-2h CD cord-287123-ldkuwcc7 176 12 - - : cord-287123-ldkuwcc7 176 13 quinazolin-3yl]-benzamide quinazolin-3yl]-benzamide NNP cord-287123-ldkuwcc7 176 14 ) ) -RRB- cord-287123-ldkuwcc7 176 15 was be VBD cord-287123-ldkuwcc7 176 16 found find VBN cord-287123-ldkuwcc7 176 17 highly highly RB cord-287123-ldkuwcc7 176 18 selective selective JJ cord-287123-ldkuwcc7 176 19 for for IN cord-287123-ldkuwcc7 176 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 176 21 as as IN cord-287123-ldkuwcc7 176 22 opposed oppose VBN cord-287123-ldkuwcc7 176 23 to to IN cord-287123-ldkuwcc7 176 24 FPR1 FPR1 NNP cord-287123-ldkuwcc7 176 25 . . . cord-287123-ldkuwcc7 177 1 It -PRON- PRP cord-287123-ldkuwcc7 177 2 was be VBD cord-287123-ldkuwcc7 177 3 identified identify VBN cord-287123-ldkuwcc7 177 4 as as IN cord-287123-ldkuwcc7 177 5 a a DT cord-287123-ldkuwcc7 177 6 biased biased JJ cord-287123-ldkuwcc7 177 7 agonist agonist NN cord-287123-ldkuwcc7 177 8 , , , cord-287123-ldkuwcc7 177 9 as as IN cord-287123-ldkuwcc7 177 10 it -PRON- PRP cord-287123-ldkuwcc7 177 11 stimulated stimulate VBD cord-287123-ldkuwcc7 177 12 calcium calcium NN cord-287123-ldkuwcc7 177 13 mobilization mobilization NN cord-287123-ldkuwcc7 177 14 through through IN cord-287123-ldkuwcc7 177 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 177 16 but but CC cord-287123-ldkuwcc7 177 17 did do VBD cord-287123-ldkuwcc7 177 18 not not RB cord-287123-ldkuwcc7 177 19 induce induce VB cord-287123-ldkuwcc7 177 20 substantial substantial JJ cord-287123-ldkuwcc7 177 21 neutrophil neutrophil NN cord-287123-ldkuwcc7 177 22 superoxide superoxide NN cord-287123-ldkuwcc7 177 23 generation generation NN cord-287123-ldkuwcc7 177 24 , , , cord-287123-ldkuwcc7 177 25 even even RB cord-287123-ldkuwcc7 177 26 at at IN cord-287123-ldkuwcc7 177 27 concentrations concentration NNS cord-287123-ldkuwcc7 178 1 up up IN cord-287123-ldkuwcc7 178 2 to to TO cord-287123-ldkuwcc7 178 3 100 100 CD cord-287123-ldkuwcc7 178 4 µM. µm. JJ cord-287123-ldkuwcc7 179 1 A a DT cord-287123-ldkuwcc7 179 2 later later JJ cord-287123-ldkuwcc7 179 3 study study NN cord-287123-ldkuwcc7 179 4 revealed reveal VBD cord-287123-ldkuwcc7 179 5 an an DT cord-287123-ldkuwcc7 179 6 anti anti JJ cord-287123-ldkuwcc7 179 7 - - JJ cord-287123-ldkuwcc7 179 8 inflammatory inflammatory JJ cord-287123-ldkuwcc7 179 9 role role NN cord-287123-ldkuwcc7 179 10 for for IN cord-287123-ldkuwcc7 179 11 Quin Quin NNP cord-287123-ldkuwcc7 179 12 - - HYPH cord-287123-ldkuwcc7 179 13 C1 C1 NNP cord-287123-ldkuwcc7 179 14 in in IN cord-287123-ldkuwcc7 179 15 bleomycin bleomycin NN cord-287123-ldkuwcc7 179 16 - - HYPH cord-287123-ldkuwcc7 179 17 induced induce VBN cord-287123-ldkuwcc7 179 18 lung lung NN cord-287123-ldkuwcc7 179 19 injury injury NN cord-287123-ldkuwcc7 179 20 in in IN cord-287123-ldkuwcc7 179 21 a a DT cord-287123-ldkuwcc7 179 22 mouse mouse NN cord-287123-ldkuwcc7 179 23 model model NN cord-287123-ldkuwcc7 179 24 [ [ -LRB- cord-287123-ldkuwcc7 179 25 142 142 CD cord-287123-ldkuwcc7 179 26 ] ] -RRB- cord-287123-ldkuwcc7 179 27 . . . cord-287123-ldkuwcc7 180 1 The the DT cord-287123-ldkuwcc7 180 2 murine murine JJ cord-287123-ldkuwcc7 180 3 receptors receptor NNS cord-287123-ldkuwcc7 180 4 for for IN cord-287123-ldkuwcc7 180 5 Quin Quin NNP cord-287123-ldkuwcc7 180 6 - - HYPH cord-287123-ldkuwcc7 180 7 C1 C1 NNP cord-287123-ldkuwcc7 180 8 were be VBD cord-287123-ldkuwcc7 180 9 determined determine VBN cord-287123-ldkuwcc7 180 10 to to TO cord-287123-ldkuwcc7 180 11 be be VB cord-287123-ldkuwcc7 180 12 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 180 13 and and CC cord-287123-ldkuwcc7 180 14 mFpr2 mFpr2 VBN cord-287123-ldkuwcc7 180 15 [ [ -LRB- cord-287123-ldkuwcc7 180 16 26 26 CD cord-287123-ldkuwcc7 180 17 ] ] -RRB- cord-287123-ldkuwcc7 180 18 . . . cord-287123-ldkuwcc7 181 1 Competitive competitive JJ cord-287123-ldkuwcc7 181 2 binding bind VBG cord-287123-ldkuwcc7 181 3 analysis analysis NN cord-287123-ldkuwcc7 181 4 showed show VBD cord-287123-ldkuwcc7 181 5 that that IN cord-287123-ldkuwcc7 181 6 Quin Quin NNP cord-287123-ldkuwcc7 181 7 - - HYPH cord-287123-ldkuwcc7 181 8 C1 C1 NNP cord-287123-ldkuwcc7 181 9 does do VBZ cord-287123-ldkuwcc7 181 10 not not RB cord-287123-ldkuwcc7 181 11 share share VB cord-287123-ldkuwcc7 181 12 the the DT cord-287123-ldkuwcc7 181 13 same same JJ cord-287123-ldkuwcc7 181 14 recognition recognition NN cord-287123-ldkuwcc7 181 15 sites site NNS cord-287123-ldkuwcc7 181 16 with with IN cord-287123-ldkuwcc7 181 17 formyl formyl NNP cord-287123-ldkuwcc7 181 18 peptides peptide NNS cord-287123-ldkuwcc7 181 19 in in IN cord-287123-ldkuwcc7 181 20 mFprs mFprs NNP cord-287123-ldkuwcc7 181 21 [ [ -LRB- cord-287123-ldkuwcc7 181 22 26 26 CD cord-287123-ldkuwcc7 181 23 ] ] -RRB- cord-287123-ldkuwcc7 181 24 . . . cord-287123-ldkuwcc7 182 1 Given give VBN cord-287123-ldkuwcc7 182 2 that that IN cord-287123-ldkuwcc7 182 3 Quin Quin NNP cord-287123-ldkuwcc7 182 4 - - HYPH cord-287123-ldkuwcc7 182 5 C1 C1 NNP cord-287123-ldkuwcc7 182 6 is be VBZ cord-287123-ldkuwcc7 182 7 non non JJ cord-287123-ldkuwcc7 182 8 - - JJ cord-287123-ldkuwcc7 182 9 competitive competitive JJ cord-287123-ldkuwcc7 182 10 with with IN cord-287123-ldkuwcc7 182 11 formyl formyl NNP cord-287123-ldkuwcc7 182 12 peptides peptide NNS cord-287123-ldkuwcc7 182 13 , , , cord-287123-ldkuwcc7 182 14 it -PRON- PRP cord-287123-ldkuwcc7 182 15 is be VBZ cord-287123-ldkuwcc7 182 16 interesting interesting JJ cord-287123-ldkuwcc7 182 17 to to TO cord-287123-ldkuwcc7 182 18 surmise surmise VB cord-287123-ldkuwcc7 182 19 that that IN cord-287123-ldkuwcc7 182 20 Quin Quin NNP cord-287123-ldkuwcc7 182 21 - - HYPH cord-287123-ldkuwcc7 182 22 C1 C1 NNP cord-287123-ldkuwcc7 182 23 may may MD cord-287123-ldkuwcc7 182 24 act act VB cord-287123-ldkuwcc7 182 25 at at IN cord-287123-ldkuwcc7 182 26 FPR2 FPR2 NNP cord-287123-ldkuwcc7 182 27 as as IN cord-287123-ldkuwcc7 182 28 an an DT cord-287123-ldkuwcc7 182 29 ago ago JJ cord-287123-ldkuwcc7 182 30 - - HYPH cord-287123-ldkuwcc7 182 31 allosteric allosteric JJ cord-287123-ldkuwcc7 182 32 modulator modulator NN cord-287123-ldkuwcc7 182 33 . . . cord-287123-ldkuwcc7 183 1 However however RB cord-287123-ldkuwcc7 183 2 , , , cord-287123-ldkuwcc7 183 3 the the DT cord-287123-ldkuwcc7 183 4 precise precise JJ cord-287123-ldkuwcc7 183 5 mechanism mechanism NN cord-287123-ldkuwcc7 183 6 for for IN cord-287123-ldkuwcc7 183 7 the the DT cord-287123-ldkuwcc7 183 8 agonistic agonistic JJ cord-287123-ldkuwcc7 183 9 activity activity NN cord-287123-ldkuwcc7 183 10 of of IN cord-287123-ldkuwcc7 183 11 Quin Quin NNP cord-287123-ldkuwcc7 183 12 - - HYPH cord-287123-ldkuwcc7 183 13 C1 C1 NNP cord-287123-ldkuwcc7 183 14 requires require VBZ cord-287123-ldkuwcc7 183 15 further further JJ cord-287123-ldkuwcc7 183 16 examination examination NN cord-287123-ldkuwcc7 183 17 . . . cord-287123-ldkuwcc7 184 1 Since since IN cord-287123-ldkuwcc7 184 2 the the DT cord-287123-ldkuwcc7 184 3 first first JJ cord-287123-ldkuwcc7 184 4 synthetic synthetic JJ cord-287123-ldkuwcc7 184 5 non non JJ cord-287123-ldkuwcc7 184 6 - - JJ cord-287123-ldkuwcc7 184 7 peptide peptide JJ cord-287123-ldkuwcc7 184 8 FPR fpr NN cord-287123-ldkuwcc7 184 9 agonist agonist NN cord-287123-ldkuwcc7 184 10 was be VBD cord-287123-ldkuwcc7 184 11 reported report VBN cord-287123-ldkuwcc7 184 12 , , , cord-287123-ldkuwcc7 184 13 an an DT cord-287123-ldkuwcc7 184 14 increasing increase VBG cord-287123-ldkuwcc7 184 15 number number NN cord-287123-ldkuwcc7 184 16 of of IN cord-287123-ldkuwcc7 184 17 small small JJ cord-287123-ldkuwcc7 184 18 - - HYPH cord-287123-ldkuwcc7 184 19 molecule molecule NN cord-287123-ldkuwcc7 184 20 agonists agonist NNS cord-287123-ldkuwcc7 184 21 have have VBP cord-287123-ldkuwcc7 184 22 been be VBN cord-287123-ldkuwcc7 184 23 discovered discover VBN cord-287123-ldkuwcc7 184 24 in in IN cord-287123-ldkuwcc7 184 25 recent recent JJ cord-287123-ldkuwcc7 184 26 years year NNS cord-287123-ldkuwcc7 184 27 [ [ -LRB- cord-287123-ldkuwcc7 184 28 6 6 CD cord-287123-ldkuwcc7 184 29 ] ] -RRB- cord-287123-ldkuwcc7 184 30 . . . cord-287123-ldkuwcc7 185 1 So so RB cord-287123-ldkuwcc7 185 2 far far RB cord-287123-ldkuwcc7 185 3 , , , cord-287123-ldkuwcc7 185 4 a a DT cord-287123-ldkuwcc7 185 5 series series NN cord-287123-ldkuwcc7 185 6 of of IN cord-287123-ldkuwcc7 185 7 structurally structurally RB cord-287123-ldkuwcc7 185 8 divergent divergent JJ cord-287123-ldkuwcc7 185 9 small small JJ cord-287123-ldkuwcc7 185 10 - - HYPH cord-287123-ldkuwcc7 185 11 molecules molecule NNS cord-287123-ldkuwcc7 185 12 with with IN cord-287123-ldkuwcc7 185 13 high high JJ cord-287123-ldkuwcc7 185 14 - - HYPH cord-287123-ldkuwcc7 185 15 affinity affinity NN cord-287123-ldkuwcc7 185 16 have have VBP cord-287123-ldkuwcc7 185 17 been be VBN cord-287123-ldkuwcc7 185 18 identified identify VBN cord-287123-ldkuwcc7 185 19 as as IN cord-287123-ldkuwcc7 185 20 FPR fpr NN cord-287123-ldkuwcc7 185 21 ligands ligand NNS cord-287123-ldkuwcc7 185 22 via via IN cord-287123-ldkuwcc7 185 23 cell cell NN cord-287123-ldkuwcc7 185 24 - - HYPH cord-287123-ldkuwcc7 185 25 based base VBN cord-287123-ldkuwcc7 185 26 assays assay NNS cord-287123-ldkuwcc7 185 27 for for IN cord-287123-ldkuwcc7 185 28 high high JJ cord-287123-ldkuwcc7 185 29 throughput throughput NN cord-287123-ldkuwcc7 185 30 screening screening NN cord-287123-ldkuwcc7 185 31 ( ( -LRB- cord-287123-ldkuwcc7 185 32 HTS HTS NNP cord-287123-ldkuwcc7 185 33 ) ) -RRB- cord-287123-ldkuwcc7 185 34 , , , cord-287123-ldkuwcc7 185 35 as as RB cord-287123-ldkuwcc7 185 36 well well RB cord-287123-ldkuwcc7 185 37 as as IN cord-287123-ldkuwcc7 185 38 structure structure NN cord-287123-ldkuwcc7 185 39 - - HYPH cord-287123-ldkuwcc7 185 40 activity activity NN cord-287123-ldkuwcc7 185 41 relationship relationship NN cord-287123-ldkuwcc7 185 42 ( ( -LRB- cord-287123-ldkuwcc7 185 43 SAR)-directed sar)-directe VBN cord-287123-ldkuwcc7 185 44 design design NN cord-287123-ldkuwcc7 185 45 and and CC cord-287123-ldkuwcc7 185 46 synthesis synthesis NN cord-287123-ldkuwcc7 185 47 [ [ -LRB- cord-287123-ldkuwcc7 185 48 82 82 CD cord-287123-ldkuwcc7 185 49 ] ] -RRB- cord-287123-ldkuwcc7 186 1 [ [ -LRB- cord-287123-ldkuwcc7 186 2 83 83 CD cord-287123-ldkuwcc7 186 3 ] ] -RRB- cord-287123-ldkuwcc7 186 4 [ [ -LRB- cord-287123-ldkuwcc7 186 5 84 84 CD cord-287123-ldkuwcc7 186 6 ] ] -RRB- cord-287123-ldkuwcc7 186 7 143 143 CD cord-287123-ldkuwcc7 186 8 , , , cord-287123-ldkuwcc7 186 9 144 144 CD cord-287123-ldkuwcc7 186 10 ] ] -RRB- cord-287123-ldkuwcc7 186 11 . . . cord-287123-ldkuwcc7 187 1 In in IN cord-287123-ldkuwcc7 187 2 general general JJ cord-287123-ldkuwcc7 187 3 , , , cord-287123-ldkuwcc7 187 4 the the DT cord-287123-ldkuwcc7 187 5 identification identification NN cord-287123-ldkuwcc7 187 6 of of IN cord-287123-ldkuwcc7 187 7 new new JJ cord-287123-ldkuwcc7 187 8 molecules molecule NNS cord-287123-ldkuwcc7 187 9 relies rely VBZ cord-287123-ldkuwcc7 187 10 on on IN cord-287123-ldkuwcc7 187 11 known know VBN cord-287123-ldkuwcc7 187 12 structures structure NNS cord-287123-ldkuwcc7 187 13 , , , cord-287123-ldkuwcc7 187 14 SAR SAR NNP cord-287123-ldkuwcc7 187 15 analysis analysis NN cord-287123-ldkuwcc7 187 16 and and CC cord-287123-ldkuwcc7 187 17 computer computer NN cord-287123-ldkuwcc7 187 18 - - HYPH cord-287123-ldkuwcc7 187 19 aided aid VBN cord-287123-ldkuwcc7 187 20 design design NN cord-287123-ldkuwcc7 187 21 . . . cord-287123-ldkuwcc7 188 1 Using use VBG cord-287123-ldkuwcc7 188 2 this this DT cord-287123-ldkuwcc7 188 3 strategy strategy NN cord-287123-ldkuwcc7 188 4 , , , cord-287123-ldkuwcc7 188 5 around around RB cord-287123-ldkuwcc7 188 6 one one CD cord-287123-ldkuwcc7 188 7 hundred hundred CD cord-287123-ldkuwcc7 188 8 FPR FPR NNP cord-287123-ldkuwcc7 188 9 agonists agonist NNS cord-287123-ldkuwcc7 188 10 with with IN cord-287123-ldkuwcc7 188 11 high high JJ cord-287123-ldkuwcc7 188 12 potency potency NN cord-287123-ldkuwcc7 188 13 and and CC cord-287123-ldkuwcc7 188 14 clear clear JJ cord-287123-ldkuwcc7 188 15 selectivity selectivity NN cord-287123-ldkuwcc7 188 16 have have VBP cord-287123-ldkuwcc7 188 17 been be VBN cord-287123-ldkuwcc7 188 18 identified identify VBN cord-287123-ldkuwcc7 188 19 and and CC cord-287123-ldkuwcc7 188 20 optimized optimize VBN cord-287123-ldkuwcc7 188 21 in in IN cord-287123-ldkuwcc7 188 22 the the DT cord-287123-ldkuwcc7 188 23 reported reported JJ cord-287123-ldkuwcc7 188 24 research research NN cord-287123-ldkuwcc7 188 25 . . . cord-287123-ldkuwcc7 189 1 Based base VBN cord-287123-ldkuwcc7 189 2 on on IN cord-287123-ldkuwcc7 189 3 the the DT cord-287123-ldkuwcc7 189 4 structures structure NNS cord-287123-ldkuwcc7 189 5 with with IN cord-287123-ldkuwcc7 189 6 varying vary VBG cord-287123-ldkuwcc7 189 7 scaffolds scaffold NNS cord-287123-ldkuwcc7 189 8 and and CC cord-287123-ldkuwcc7 189 9 SAR SAR NNP cord-287123-ldkuwcc7 189 10 - - HYPH cord-287123-ldkuwcc7 189 11 directed direct VBN cord-287123-ldkuwcc7 189 12 evaluation evaluation NN cord-287123-ldkuwcc7 189 13 , , , cord-287123-ldkuwcc7 189 14 these these DT cord-287123-ldkuwcc7 189 15 small small JJ cord-287123-ldkuwcc7 189 16 compounds compound NNS cord-287123-ldkuwcc7 189 17 fall fall VBP cord-287123-ldkuwcc7 189 18 into into IN cord-287123-ldkuwcc7 189 19 at at RB cord-287123-ldkuwcc7 189 20 least least RBS cord-287123-ldkuwcc7 189 21 10 10 CD cord-287123-ldkuwcc7 189 22 groups group NNS cord-287123-ldkuwcc7 189 23 : : : cord-287123-ldkuwcc7 189 24 benzimidazoles benzimidazoles NNP cord-287123-ldkuwcc7 189 25 , , , cord-287123-ldkuwcc7 189 26 pyrazolones pyrazolones NNP cord-287123-ldkuwcc7 189 27 ( ( -LRB- cord-287123-ldkuwcc7 189 28 e.g. e.g. RB cord-287123-ldkuwcc7 189 29 , , , cord-287123-ldkuwcc7 189 30 Compound Compound NNP cord-287123-ldkuwcc7 189 31 43 43 CD cord-287123-ldkuwcc7 189 32 ) ) -RRB- cord-287123-ldkuwcc7 189 33 , , , cord-287123-ldkuwcc7 189 34 N n CD cord-287123-ldkuwcc7 189 35 - - HYPH cord-287123-ldkuwcc7 189 36 substituted substitute VBN cord-287123-ldkuwcc7 189 37 benzimidazoles benzimidazole NNS cord-287123-ldkuwcc7 189 38 , , , cord-287123-ldkuwcc7 189 39 pyridazin-3(2H)-ones pyridazin-3(2h)-one NNS cord-287123-ldkuwcc7 189 40 , , , cord-287123-ldkuwcc7 189 41 chiral chiral JJ cord-287123-ldkuwcc7 189 42 pyridazines pyridazine NNS cord-287123-ldkuwcc7 189 43 , , , cord-287123-ldkuwcc7 189 44 N N NNP cord-287123-ldkuwcc7 189 45 - - HYPH cord-287123-ldkuwcc7 189 46 phenylureas phenylureas NNP cord-287123-ldkuwcc7 189 47 , , , cord-287123-ldkuwcc7 189 48 chiral chiral JJ cord-287123-ldkuwcc7 189 49 3-(1H 3-(1h CD cord-287123-ldkuwcc7 189 50 - - : cord-287123-ldkuwcc7 189 51 indol-3-yl)-2-[3-(4-nitrophenyl indol-3-yl)-2-[3-(4-nitrophenyl CD cord-287123-ldkuwcc7 189 52 ) ) -RRB- cord-287123-ldkuwcc7 189 53 ureido ureido NNP cord-287123-ldkuwcc7 189 54 ] ] -RRB- cord-287123-ldkuwcc7 189 55 propanamides propanamide NNS cord-287123-ldkuwcc7 189 56 , , , cord-287123-ldkuwcc7 189 57 2-(N 2-(n CD cord-287123-ldkuwcc7 189 58 - - HYPH cord-287123-ldkuwcc7 189 59 Piperazinyl)acetamide piperazinyl)acetamide JJ cord-287123-ldkuwcc7 189 60 derivatives derivative NNS cord-287123-ldkuwcc7 189 61 , , , cord-287123-ldkuwcc7 189 62 quinazolinones quinazolinones NNP cord-287123-ldkuwcc7 189 63 ( ( -LRB- cord-287123-ldkuwcc7 189 64 exemplified exemplify VBN cord-287123-ldkuwcc7 189 65 by by IN cord-287123-ldkuwcc7 189 66 Quin Quin NNP cord-287123-ldkuwcc7 189 67 - - HYPH cord-287123-ldkuwcc7 189 68 C1 C1 NNP cord-287123-ldkuwcc7 189 69 ) ) -RRB- cord-287123-ldkuwcc7 189 70 , , , cord-287123-ldkuwcc7 189 71 and and CC cord-287123-ldkuwcc7 189 72 other other JJ cord-287123-ldkuwcc7 189 73 derivatives derivative NNS cord-287123-ldkuwcc7 189 74 ( ( -LRB- cord-287123-ldkuwcc7 189 75 reviewed review VBN cord-287123-ldkuwcc7 189 76 by by IN cord-287123-ldkuwcc7 189 77 [ [ -LRB- cord-287123-ldkuwcc7 189 78 6 6 CD cord-287123-ldkuwcc7 189 79 ] ] -RRB- cord-287123-ldkuwcc7 189 80 ) ) -RRB- cord-287123-ldkuwcc7 189 81 . . . cord-287123-ldkuwcc7 190 1 Among among IN cord-287123-ldkuwcc7 190 2 these these DT cord-287123-ldkuwcc7 190 3 molecules molecule NNS cord-287123-ldkuwcc7 190 4 , , , cord-287123-ldkuwcc7 190 5 the the DT cord-287123-ldkuwcc7 190 6 most most RBS cord-287123-ldkuwcc7 190 7 potent potent JJ cord-287123-ldkuwcc7 190 8 FPR1-selective fpr1-selective JJ cord-287123-ldkuwcc7 190 9 agonist agonist NN cord-287123-ldkuwcc7 190 10 was be VBD cord-287123-ldkuwcc7 190 11 identified identify VBN cord-287123-ldkuwcc7 190 12 to to TO cord-287123-ldkuwcc7 190 13 be be VB cord-287123-ldkuwcc7 190 14 a a DT cord-287123-ldkuwcc7 190 15 polyphenylure polyphenylure NN cord-287123-ldkuwcc7 190 16 derivative derivative NN cord-287123-ldkuwcc7 190 17 with with IN cord-287123-ldkuwcc7 190 18 an an DT cord-287123-ldkuwcc7 190 19 EC EC NNP cord-287123-ldkuwcc7 190 20 50 50 CD cord-287123-ldkuwcc7 190 21 of of IN cord-287123-ldkuwcc7 190 22 131 131 CD cord-287123-ldkuwcc7 190 23 nM nm CD cord-287123-ldkuwcc7 190 24 in in IN cord-287123-ldkuwcc7 190 25 calcium calcium NN cord-287123-ldkuwcc7 190 26 flux flux NN cord-287123-ldkuwcc7 190 27 assays assay NNS cord-287123-ldkuwcc7 190 28 and and CC cord-287123-ldkuwcc7 190 29 a a DT cord-287123-ldkuwcc7 190 30 Ki Ki NNP cord-287123-ldkuwcc7 190 31 of of IN cord-287123-ldkuwcc7 190 32 4 4 CD cord-287123-ldkuwcc7 190 33 nM nm NN cord-287123-ldkuwcc7 190 34 in in IN cord-287123-ldkuwcc7 190 35 binding bind VBG cord-287123-ldkuwcc7 190 36 assays assay NNS cord-287123-ldkuwcc7 190 37 . . . cord-287123-ldkuwcc7 191 1 This this DT cord-287123-ldkuwcc7 191 2 compound compound NN cord-287123-ldkuwcc7 191 3 , , , cord-287123-ldkuwcc7 191 4 [ [ -LRB- cord-287123-ldkuwcc7 191 5 3-phenyl-1-((R)-1-(3-phenyl-1-((S)-1-(3-phenylureido)propan-2-yl)ureido)hexan-2-yl)-1-(4-phenylbutyl)urea 3-phenyl-1-((r)-1-(3-phenyl-1-((s)-1-(3-phenylureido)propan-2-yl)ureido)hexan-2-yl)-1-(4-phenylbutyl)urea CD cord-287123-ldkuwcc7 191 6 ] ] -RRB- cord-287123-ldkuwcc7 191 7 , , , cord-287123-ldkuwcc7 191 8 coded code VBN cord-287123-ldkuwcc7 191 9 as as IN cord-287123-ldkuwcc7 191 10 1753 1753 CD cord-287123-ldkuwcc7 191 11 - - SYM cord-287123-ldkuwcc7 191 12 103 103 CD cord-287123-ldkuwcc7 191 13 is be VBZ cord-287123-ldkuwcc7 191 14 also also RB cord-287123-ldkuwcc7 191 15 the the DT cord-287123-ldkuwcc7 191 16 most most RBS cord-287123-ldkuwcc7 191 17 potent potent JJ cord-287123-ldkuwcc7 191 18 synthetic synthetic JJ cord-287123-ldkuwcc7 191 19 non non JJ cord-287123-ldkuwcc7 191 20 - - JJ cord-287123-ldkuwcc7 191 21 peptide peptide JJ cord-287123-ldkuwcc7 191 22 agonist agonist NN cord-287123-ldkuwcc7 191 23 for for IN cord-287123-ldkuwcc7 191 24 FPR1 FPR1 NNP cord-287123-ldkuwcc7 191 25 known know VBN cord-287123-ldkuwcc7 191 26 to to IN cord-287123-ldkuwcc7 191 27 date date NN cord-287123-ldkuwcc7 191 28 [ [ -LRB- cord-287123-ldkuwcc7 191 29 84 84 CD cord-287123-ldkuwcc7 191 30 ] ] -RRB- cord-287123-ldkuwcc7 191 31 . . . cord-287123-ldkuwcc7 192 1 In in IN cord-287123-ldkuwcc7 192 2 addition addition NN cord-287123-ldkuwcc7 192 3 to to IN cord-287123-ldkuwcc7 192 4 1753 1753 CD cord-287123-ldkuwcc7 192 5 - - SYM cord-287123-ldkuwcc7 192 6 103 103 CD cord-287123-ldkuwcc7 192 7 , , , cord-287123-ldkuwcc7 192 8 other other JJ cord-287123-ldkuwcc7 192 9 chemical chemical NN cord-287123-ldkuwcc7 192 10 agonists agonist NNS cord-287123-ldkuwcc7 192 11 with with IN cord-287123-ldkuwcc7 192 12 high high JJ cord-287123-ldkuwcc7 192 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 192 14 specificity specificity NN cord-287123-ldkuwcc7 192 15 , , , cord-287123-ldkuwcc7 192 16 such such JJ cord-287123-ldkuwcc7 192 17 as as IN cord-287123-ldkuwcc7 192 18 the the DT cord-287123-ldkuwcc7 192 19 benzimidazole benzimidazole NNP cord-287123-ldkuwcc7 192 20 derivates derivate NNS cord-287123-ldkuwcc7 192 21 [ [ -LRB- cord-287123-ldkuwcc7 192 22 145 145 CD cord-287123-ldkuwcc7 192 23 ] ] -RRB- cord-287123-ldkuwcc7 192 24 and and CC cord-287123-ldkuwcc7 192 25 the the DT cord-287123-ldkuwcc7 192 26 pyridazinone pyridazinone NN cord-287123-ldkuwcc7 192 27 - - HYPH cord-287123-ldkuwcc7 192 28 based base VBN cord-287123-ldkuwcc7 192 29 compounds compound NNS cord-287123-ldkuwcc7 192 30 [ [ -LRB- cord-287123-ldkuwcc7 192 31 146 146 CD cord-287123-ldkuwcc7 192 32 ] ] -RRB- cord-287123-ldkuwcc7 192 33 , , , cord-287123-ldkuwcc7 192 34 have have VBP cord-287123-ldkuwcc7 192 35 been be VBN cord-287123-ldkuwcc7 192 36 described describe VBN cord-287123-ldkuwcc7 192 37 , , , cord-287123-ldkuwcc7 192 38 although although IN cord-287123-ldkuwcc7 192 39 they -PRON- PRP cord-287123-ldkuwcc7 192 40 act act VBP cord-287123-ldkuwcc7 192 41 with with IN cord-287123-ldkuwcc7 192 42 EC EC NNP cord-287123-ldkuwcc7 192 43 50 50 CD cord-287123-ldkuwcc7 192 44 above above IN cord-287123-ldkuwcc7 192 45 micromolar micromolar NNP cord-287123-ldkuwcc7 192 46 ( ( -LRB- cord-287123-ldkuwcc7 192 47 > > NFP cord-287123-ldkuwcc7 192 48 1.5 1.5 CD cord-287123-ldkuwcc7 192 49 µM µM NNS cord-287123-ldkuwcc7 192 50 ) ) -RRB- cord-287123-ldkuwcc7 192 51 . . . cord-287123-ldkuwcc7 193 1 Compared compare VBN cord-287123-ldkuwcc7 193 2 with with IN cord-287123-ldkuwcc7 193 3 FPR1 FPR1 NNP cord-287123-ldkuwcc7 193 4 , , , cord-287123-ldkuwcc7 193 5 FPR2 FPR2 NNP cord-287123-ldkuwcc7 193 6 have have VBP cord-287123-ldkuwcc7 193 7 more more RBR cord-287123-ldkuwcc7 193 8 specific specific JJ cord-287123-ldkuwcc7 193 9 and and CC cord-287123-ldkuwcc7 193 10 potent potent JJ cord-287123-ldkuwcc7 193 11 agonists agonist NNS cord-287123-ldkuwcc7 193 12 identified identify VBN cord-287123-ldkuwcc7 193 13 from from IN cord-287123-ldkuwcc7 193 14 screening screening NN cord-287123-ldkuwcc7 193 15 of of IN cord-287123-ldkuwcc7 193 16 compound compound NN cord-287123-ldkuwcc7 193 17 library library NN cord-287123-ldkuwcc7 193 18 and and CC cord-287123-ldkuwcc7 193 19 through through IN cord-287123-ldkuwcc7 193 20 rational rational JJ cord-287123-ldkuwcc7 193 21 design design NN cord-287123-ldkuwcc7 193 22 . . . cord-287123-ldkuwcc7 194 1 Currently currently RB cord-287123-ldkuwcc7 194 2 , , , cord-287123-ldkuwcc7 194 3 more more JJR cord-287123-ldkuwcc7 194 4 than than IN cord-287123-ldkuwcc7 194 5 10 10 CD cord-287123-ldkuwcc7 194 6 FPR2-slective FPR2-slective NNP cord-287123-ldkuwcc7 194 7 agonists agonist NNS cord-287123-ldkuwcc7 194 8 have have VBP cord-287123-ldkuwcc7 194 9 been be VBN cord-287123-ldkuwcc7 194 10 reported report VBN cord-287123-ldkuwcc7 194 11 to to TO cord-287123-ldkuwcc7 194 12 have have VB cord-287123-ldkuwcc7 194 13 an an DT cord-287123-ldkuwcc7 194 14 EC EC NNP cord-287123-ldkuwcc7 194 15 50 50 CD cord-287123-ldkuwcc7 194 16 in in IN cord-287123-ldkuwcc7 194 17 the the DT cord-287123-ldkuwcc7 194 18 nanomolar nanomolar JJ cord-287123-ldkuwcc7 194 19 range range NN cord-287123-ldkuwcc7 194 20 in in IN cord-287123-ldkuwcc7 194 21 functional functional JJ cord-287123-ldkuwcc7 194 22 assays assay NNS cord-287123-ldkuwcc7 194 23 , , , cord-287123-ldkuwcc7 194 24 including include VBG cord-287123-ldkuwcc7 194 25 three three CD cord-287123-ldkuwcc7 194 26 pyrazolone pyrazolone NN cord-287123-ldkuwcc7 194 27 derivatives derivative NNS cord-287123-ldkuwcc7 194 28 [ [ -LRB- cord-287123-ldkuwcc7 194 29 78 78 CD cord-287123-ldkuwcc7 194 30 ] ] -RRB- cord-287123-ldkuwcc7 194 31 , , , cord-287123-ldkuwcc7 194 32 an an DT cord-287123-ldkuwcc7 194 33 N n CD cord-287123-ldkuwcc7 194 34 - - HYPH cord-287123-ldkuwcc7 194 35 substituted substitute VBN cord-287123-ldkuwcc7 194 36 benzimidazole benzimidazole NN cord-287123-ldkuwcc7 194 37 derivative derivative JJ cord-287123-ldkuwcc7 194 38 [ [ -LRB- cord-287123-ldkuwcc7 194 39 77 77 CD cord-287123-ldkuwcc7 194 40 ] ] -RRB- cord-287123-ldkuwcc7 194 41 , , , cord-287123-ldkuwcc7 194 42 an an DT cord-287123-ldkuwcc7 194 43 N N NNP cord-287123-ldkuwcc7 194 44 - - HYPH cord-287123-ldkuwcc7 194 45 phenylurea phenylurea NN cord-287123-ldkuwcc7 194 46 derivative derivative NN cord-287123-ldkuwcc7 194 47 [ [ -LRB- cord-287123-ldkuwcc7 194 48 147 147 CD cord-287123-ldkuwcc7 194 49 ] ] -RRB- cord-287123-ldkuwcc7 194 50 , , , cord-287123-ldkuwcc7 194 51 a a DT cord-287123-ldkuwcc7 194 52 chiral chiral JJ cord-287123-ldkuwcc7 194 53 N N NNP cord-287123-ldkuwcc7 194 54 - - HYPH cord-287123-ldkuwcc7 194 55 phenylurea phenylurea NN cord-287123-ldkuwcc7 194 56 derivative derivative NN cord-287123-ldkuwcc7 194 57 [ [ -LRB- cord-287123-ldkuwcc7 194 58 148 148 CD cord-287123-ldkuwcc7 194 59 ] ] -RRB- cord-287123-ldkuwcc7 194 60 , , , cord-287123-ldkuwcc7 194 61 two two CD cord-287123-ldkuwcc7 194 62 benzodioxole benzodioxole NNP cord-287123-ldkuwcc7 194 63 derivatives derivative NNS cord-287123-ldkuwcc7 194 64 of of IN cord-287123-ldkuwcc7 194 65 N N NNP cord-287123-ldkuwcc7 194 66 - - HYPH cord-287123-ldkuwcc7 194 67 phenylureas phenylureas NNP cord-287123-ldkuwcc7 194 68 [ [ -LRB- cord-287123-ldkuwcc7 194 69 148 148 CD cord-287123-ldkuwcc7 194 70 ] ] -RRB- cord-287123-ldkuwcc7 194 71 , , , cord-287123-ldkuwcc7 194 72 six six CD cord-287123-ldkuwcc7 194 73 chiral chiral JJ cord-287123-ldkuwcc7 194 74 ureidopropanamido ureidopropanamido JJ cord-287123-ldkuwcc7 194 75 derivatives derivative NNS cord-287123-ldkuwcc7 194 76 [ [ -LRB- cord-287123-ldkuwcc7 194 77 82 82 CD cord-287123-ldkuwcc7 194 78 , , , cord-287123-ldkuwcc7 194 79 83 83 CD cord-287123-ldkuwcc7 194 80 ] ] -RRB- cord-287123-ldkuwcc7 194 81 , , , cord-287123-ldkuwcc7 194 82 a a DT cord-287123-ldkuwcc7 194 83 phenylsubstituted phenylsubstitute VBN cord-287123-ldkuwcc7 194 84 urea urea NN cord-287123-ldkuwcc7 194 85 compound compound NN cord-287123-ldkuwcc7 194 86 [ [ -LRB- cord-287123-ldkuwcc7 194 87 143 143 CD cord-287123-ldkuwcc7 194 88 ] ] -RRB- cord-287123-ldkuwcc7 194 89 , , , cord-287123-ldkuwcc7 194 90 a a DT cord-287123-ldkuwcc7 194 91 compound compound NN cord-287123-ldkuwcc7 194 92 with with IN cord-287123-ldkuwcc7 194 93 a a DT cord-287123-ldkuwcc7 194 94 unique unique JJ cord-287123-ldkuwcc7 194 95 2-(4-phenyl-5-((phenylamino)methyl)-1,2,4-triazol-3-ylthio 2-(4-phenyl-5-((phenylamino)methyl)-1,2,4-triazol-3-ylthio CD cord-287123-ldkuwcc7 194 96 ) ) -RRB- cord-287123-ldkuwcc7 194 97 acetamide acetamide NNP cord-287123-ldkuwcc7 194 98 scaffold scaffold NN cord-287123-ldkuwcc7 194 99 [ [ -LRB- cord-287123-ldkuwcc7 194 100 143 143 CD cord-287123-ldkuwcc7 194 101 ] ] -RRB- cord-287123-ldkuwcc7 194 102 , , , cord-287123-ldkuwcc7 194 103 and and CC cord-287123-ldkuwcc7 194 104 a a DT cord-287123-ldkuwcc7 194 105 pyrrolidine pyrrolidine JJ cord-287123-ldkuwcc7 194 106 bis bis JJ cord-287123-ldkuwcc7 194 107 - - HYPH cord-287123-ldkuwcc7 194 108 diketopiperazine diketopiperazine NN cord-287123-ldkuwcc7 194 109 derivative derivative JJ cord-287123-ldkuwcc7 194 110 [ [ -LRB- cord-287123-ldkuwcc7 194 111 84 84 CD cord-287123-ldkuwcc7 194 112 ] ] -RRB- cord-287123-ldkuwcc7 194 113 . . . cord-287123-ldkuwcc7 195 1 As as IN cord-287123-ldkuwcc7 195 2 expected expect VBN cord-287123-ldkuwcc7 195 3 , , , cord-287123-ldkuwcc7 195 4 there there EX cord-287123-ldkuwcc7 195 5 are be VBP cord-287123-ldkuwcc7 195 6 numerous numerous JJ cord-287123-ldkuwcc7 195 7 agonists agonist NNS cord-287123-ldkuwcc7 195 8 with with IN cord-287123-ldkuwcc7 195 9 dual dual JJ cord-287123-ldkuwcc7 195 10 specificity specificity NN cord-287123-ldkuwcc7 195 11 ( ( -LRB- cord-287123-ldkuwcc7 195 12 FPR1 FPR1 NNP cord-287123-ldkuwcc7 195 13 / / SYM cord-287123-ldkuwcc7 195 14 FPR2 FPR2 NNP cord-287123-ldkuwcc7 195 15 ) ) -RRB- cord-287123-ldkuwcc7 195 16 ( ( -LRB- cord-287123-ldkuwcc7 195 17 reviewed review VBN cord-287123-ldkuwcc7 195 18 by by IN cord-287123-ldkuwcc7 195 19 [ [ -LRB- cord-287123-ldkuwcc7 195 20 6 6 CD cord-287123-ldkuwcc7 195 21 ] ] -RRB- cord-287123-ldkuwcc7 195 22 ) ) -RRB- cord-287123-ldkuwcc7 195 23 . . . cord-287123-ldkuwcc7 196 1 Noting note VBG cord-287123-ldkuwcc7 196 2 that that IN cord-287123-ldkuwcc7 196 3 a a DT cord-287123-ldkuwcc7 196 4 pyrazolone pyrazolone NN cord-287123-ldkuwcc7 196 5 derivative derivative NN cord-287123-ldkuwcc7 196 6 , , , cord-287123-ldkuwcc7 196 7 designated designate VBN cord-287123-ldkuwcc7 196 8 in in IN cord-287123-ldkuwcc7 196 9 most most JJS cord-287123-ldkuwcc7 196 10 publications publication NNS cord-287123-ldkuwcc7 196 11 as as IN cord-287123-ldkuwcc7 196 12 " " `` cord-287123-ldkuwcc7 196 13 Compound Compound NNP cord-287123-ldkuwcc7 196 14 43 43 CD cord-287123-ldkuwcc7 196 15 " " '' cord-287123-ldkuwcc7 196 16 , , , cord-287123-ldkuwcc7 196 17 was be VBD cord-287123-ldkuwcc7 196 18 first first RB cord-287123-ldkuwcc7 196 19 identified identify VBN cord-287123-ldkuwcc7 196 20 as as IN cord-287123-ldkuwcc7 196 21 a a DT cord-287123-ldkuwcc7 196 22 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 196 23 agonist agonist NN cord-287123-ldkuwcc7 196 24 [ [ -LRB- cord-287123-ldkuwcc7 196 25 78 78 CD cord-287123-ldkuwcc7 196 26 ] ] -RRB- cord-287123-ldkuwcc7 196 27 , , , cord-287123-ldkuwcc7 196 28 but but CC cord-287123-ldkuwcc7 196 29 it -PRON- PRP cord-287123-ldkuwcc7 196 30 was be VBD cord-287123-ldkuwcc7 196 31 redefined redefine VBN cord-287123-ldkuwcc7 196 32 to to TO cord-287123-ldkuwcc7 196 33 be be VB cord-287123-ldkuwcc7 196 34 a a DT cord-287123-ldkuwcc7 196 35 mixed mixed JJ cord-287123-ldkuwcc7 196 36 FPR1 FPR1 NNP cord-287123-ldkuwcc7 196 37 / / SYM cord-287123-ldkuwcc7 196 38 FPR2 FPR2 NNP cord-287123-ldkuwcc7 196 39 agonist agonist NN cord-287123-ldkuwcc7 196 40 in in IN cord-287123-ldkuwcc7 196 41 an an DT cord-287123-ldkuwcc7 196 42 independent independent JJ cord-287123-ldkuwcc7 196 43 screen screen NN cord-287123-ldkuwcc7 196 44 recently recently RB cord-287123-ldkuwcc7 196 45 [ [ -LRB- cord-287123-ldkuwcc7 196 46 79 79 CD cord-287123-ldkuwcc7 196 47 ] ] -RRB- cord-287123-ldkuwcc7 196 48 . . . cord-287123-ldkuwcc7 197 1 It -PRON- PRP cord-287123-ldkuwcc7 197 2 is be VBZ cord-287123-ldkuwcc7 197 3 not not RB cord-287123-ldkuwcc7 197 4 clear clear JJ cord-287123-ldkuwcc7 197 5 for for IN cord-287123-ldkuwcc7 197 6 most most JJS cord-287123-ldkuwcc7 197 7 of of IN cord-287123-ldkuwcc7 197 8 the the DT cord-287123-ldkuwcc7 197 9 reported report VBN cord-287123-ldkuwcc7 197 10 small small JJ cord-287123-ldkuwcc7 197 11 molecule molecule NN cord-287123-ldkuwcc7 197 12 agonists agonist NNS cord-287123-ldkuwcc7 197 13 whether whether IN cord-287123-ldkuwcc7 197 14 they -PRON- PRP cord-287123-ldkuwcc7 197 15 interact interact VBP cord-287123-ldkuwcc7 197 16 with with IN cord-287123-ldkuwcc7 197 17 murine murine JJ cord-287123-ldkuwcc7 197 18 formyl formyl NNP cord-287123-ldkuwcc7 197 19 peptide peptide NN cord-287123-ldkuwcc7 197 20 receptors receptor NNS cord-287123-ldkuwcc7 197 21 since since IN cord-287123-ldkuwcc7 197 22 they -PRON- PRP cord-287123-ldkuwcc7 197 23 are be VBP cord-287123-ldkuwcc7 197 24 designed design VBN cord-287123-ldkuwcc7 197 25 and and CC cord-287123-ldkuwcc7 197 26 screened screen VBN cord-287123-ldkuwcc7 197 27 to to TO cord-287123-ldkuwcc7 197 28 target target VB cord-287123-ldkuwcc7 197 29 human human JJ cord-287123-ldkuwcc7 197 30 FPRs fpr NNS cord-287123-ldkuwcc7 197 31 and and CC cord-287123-ldkuwcc7 197 32 murine murine JJ cord-287123-ldkuwcc7 197 33 FPRs fpr NNS cord-287123-ldkuwcc7 197 34 have have VBP cord-287123-ldkuwcc7 197 35 distinct distinct JJ cord-287123-ldkuwcc7 197 36 properties property NNS cord-287123-ldkuwcc7 197 37 compared compare VBN cord-287123-ldkuwcc7 197 38 to to IN cord-287123-ldkuwcc7 197 39 their -PRON- PRP$ cord-287123-ldkuwcc7 197 40 human human JJ cord-287123-ldkuwcc7 197 41 counterparts counterpart NNS cord-287123-ldkuwcc7 197 42 . . . cord-287123-ldkuwcc7 198 1 Lipoxin Lipoxin NNP cord-287123-ldkuwcc7 198 2 A4 A4 NNP cord-287123-ldkuwcc7 198 3 ( ( -LRB- cord-287123-ldkuwcc7 198 4 LXA4 LXA4 NNP cord-287123-ldkuwcc7 198 5 ) ) -RRB- cord-287123-ldkuwcc7 198 6 , , , cord-287123-ldkuwcc7 198 7 derived derive VBN cord-287123-ldkuwcc7 198 8 from from IN cord-287123-ldkuwcc7 198 9 arachidonic arachidonic JJ cord-287123-ldkuwcc7 198 10 acid acid NN cord-287123-ldkuwcc7 198 11 , , , cord-287123-ldkuwcc7 198 12 has have VBZ cord-287123-ldkuwcc7 198 13 highly highly RB cord-287123-ldkuwcc7 198 14 potent potent JJ cord-287123-ldkuwcc7 198 15 anti anti JJ cord-287123-ldkuwcc7 198 16 - - JJ cord-287123-ldkuwcc7 198 17 inflammatory inflammatory JJ cord-287123-ldkuwcc7 198 18 and and CC cord-287123-ldkuwcc7 198 19 pro pro JJ cord-287123-ldkuwcc7 198 20 - - JJ cord-287123-ldkuwcc7 198 21 resolving resolve VBG cord-287123-ldkuwcc7 198 22 activities activity NNS cord-287123-ldkuwcc7 198 23 based base VBN cord-287123-ldkuwcc7 198 24 on on IN cord-287123-ldkuwcc7 198 25 in in IN cord-287123-ldkuwcc7 198 26 vivo vivo NN cord-287123-ldkuwcc7 198 27 studies study NNS cord-287123-ldkuwcc7 198 28 [ [ -LRB- cord-287123-ldkuwcc7 198 29 149 149 CD cord-287123-ldkuwcc7 198 30 ] ] -RRB- cord-287123-ldkuwcc7 199 1 [ [ -LRB- cord-287123-ldkuwcc7 199 2 150 150 CD cord-287123-ldkuwcc7 199 3 ] ] -RRB- cord-287123-ldkuwcc7 199 4 [ [ -LRB- cord-287123-ldkuwcc7 199 5 151 151 CD cord-287123-ldkuwcc7 199 6 ] ] -RRB- cord-287123-ldkuwcc7 199 7 [ [ -LRB- cord-287123-ldkuwcc7 199 8 152 152 CD cord-287123-ldkuwcc7 199 9 ] ] -RRB- cord-287123-ldkuwcc7 199 10 . . . cord-287123-ldkuwcc7 200 1 This this DT cord-287123-ldkuwcc7 200 2 eicosanoid eicosanoid NN cord-287123-ldkuwcc7 200 3 was be VBD cord-287123-ldkuwcc7 200 4 reported report VBN cord-287123-ldkuwcc7 200 5 to to TO cord-287123-ldkuwcc7 200 6 directly directly RB cord-287123-ldkuwcc7 200 7 bind bind VB cord-287123-ldkuwcc7 200 8 to to IN cord-287123-ldkuwcc7 200 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 200 10 and and CC cord-287123-ldkuwcc7 200 11 a a DT cord-287123-ldkuwcc7 200 12 variant variant NN cord-287123-ldkuwcc7 200 13 of of IN cord-287123-ldkuwcc7 200 14 mouse mouse NN cord-287123-ldkuwcc7 200 15 mFpr mFpr NNP cord-287123-ldkuwcc7 200 16 - - HYPH cord-287123-ldkuwcc7 200 17 rs1 rs1 NNP cord-287123-ldkuwcc7 200 18 [ [ -LRB- cord-287123-ldkuwcc7 200 19 34 34 CD cord-287123-ldkuwcc7 200 20 , , , cord-287123-ldkuwcc7 200 21 74 74 CD cord-287123-ldkuwcc7 200 22 , , , cord-287123-ldkuwcc7 200 23 149 149 CD cord-287123-ldkuwcc7 200 24 , , , cord-287123-ldkuwcc7 200 25 153 153 CD cord-287123-ldkuwcc7 200 26 ] ] -RRB- cord-287123-ldkuwcc7 200 27 . . . cord-287123-ldkuwcc7 201 1 LXA4 LXA4 NNP cord-287123-ldkuwcc7 201 2 was be VBD cord-287123-ldkuwcc7 201 3 shown show VBN cord-287123-ldkuwcc7 201 4 to to TO cord-287123-ldkuwcc7 201 5 have have VB cord-287123-ldkuwcc7 201 6 a a DT cord-287123-ldkuwcc7 201 7 high high JJ cord-287123-ldkuwcc7 201 8 affinity affinity NN cord-287123-ldkuwcc7 201 9 ( ( -LRB- cord-287123-ldkuwcc7 202 1 K K NNP cord-287123-ldkuwcc7 202 2 d d NNP cord-287123-ldkuwcc7 202 3 of~1.7 of~1.7 NNP cord-287123-ldkuwcc7 202 4 nM nM NNP cord-287123-ldkuwcc7 202 5 ) ) -RRB- cord-287123-ldkuwcc7 202 6 in in IN cord-287123-ldkuwcc7 202 7 binding bind VBG cord-287123-ldkuwcc7 202 8 to to IN cord-287123-ldkuwcc7 202 9 FPR2-expressing fpr2-expresse VBG cord-287123-ldkuwcc7 202 10 Chinese chinese JJ cord-287123-ldkuwcc7 202 11 hamster hamster NN cord-287123-ldkuwcc7 202 12 ovary ovary NN cord-287123-ldkuwcc7 202 13 cells cell NNS cord-287123-ldkuwcc7 202 14 [ [ -LRB- cord-287123-ldkuwcc7 202 15 74 74 CD cord-287123-ldkuwcc7 202 16 ] ] -RRB- cord-287123-ldkuwcc7 202 17 . . . cord-287123-ldkuwcc7 203 1 Despite despite IN cord-287123-ldkuwcc7 203 2 the the DT cord-287123-ldkuwcc7 203 3 high high JJ cord-287123-ldkuwcc7 203 4 - - HYPH cord-287123-ldkuwcc7 203 5 affinity affinity NN cord-287123-ldkuwcc7 203 6 binding binding NN cord-287123-ldkuwcc7 203 7 , , , cord-287123-ldkuwcc7 203 8 LXA4 LXA4 NNP cord-287123-ldkuwcc7 203 9 is be VBZ cord-287123-ldkuwcc7 203 10 an an DT cord-287123-ldkuwcc7 203 11 atypical atypical JJ cord-287123-ldkuwcc7 203 12 ligand ligand NN cord-287123-ldkuwcc7 203 13 for for IN cord-287123-ldkuwcc7 203 14 FPR2 FPR2 NNP cord-287123-ldkuwcc7 203 15 as as IN cord-287123-ldkuwcc7 203 16 it -PRON- PRP cord-287123-ldkuwcc7 203 17 can can MD cord-287123-ldkuwcc7 203 18 not not RB cord-287123-ldkuwcc7 203 19 activate activate VB cord-287123-ldkuwcc7 203 20 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 203 21 activities activity NNS cord-287123-ldkuwcc7 203 22 such such JJ cord-287123-ldkuwcc7 203 23 as as IN cord-287123-ldkuwcc7 203 24 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 203 25 , , , cord-287123-ldkuwcc7 203 26 enzyme enzyme NN cord-287123-ldkuwcc7 203 27 release release NN cord-287123-ldkuwcc7 203 28 and and CC cord-287123-ldkuwcc7 203 29 ROS ROS NNP cord-287123-ldkuwcc7 203 30 production production NN cord-287123-ldkuwcc7 203 31 . . . cord-287123-ldkuwcc7 204 1 LXA4 LXA4 NNP cord-287123-ldkuwcc7 204 2 also also RB cord-287123-ldkuwcc7 204 3 fails fail VBZ cord-287123-ldkuwcc7 204 4 to to TO cord-287123-ldkuwcc7 204 5 activate activate VB cord-287123-ldkuwcc7 204 6 FPR2-dependent FPR2-dependent NNP cord-287123-ldkuwcc7 204 7 signaling signal VBG cord-287123-ldkuwcc7 204 8 , , , cord-287123-ldkuwcc7 204 9 such such JJ cord-287123-ldkuwcc7 204 10 as as IN cord-287123-ldkuwcc7 204 11 calcium calcium NN cord-287123-ldkuwcc7 204 12 mobilization mobilization NN cord-287123-ldkuwcc7 204 13 , , , cord-287123-ldkuwcc7 204 14 in in IN cord-287123-ldkuwcc7 204 15 transfected transfecte VBN cord-287123-ldkuwcc7 204 16 cell cell NN cord-287123-ldkuwcc7 204 17 lines line NNS cord-287123-ldkuwcc7 204 18 [ [ -LRB- cord-287123-ldkuwcc7 204 19 154 154 CD cord-287123-ldkuwcc7 204 20 ] ] -RRB- cord-287123-ldkuwcc7 204 21 [ [ -LRB- cord-287123-ldkuwcc7 204 22 155 155 CD cord-287123-ldkuwcc7 204 23 ] ] -RRB- cord-287123-ldkuwcc7 204 24 [ [ -LRB- cord-287123-ldkuwcc7 204 25 156 156 CD cord-287123-ldkuwcc7 204 26 ] ] -RRB- cord-287123-ldkuwcc7 204 27 . . . cord-287123-ldkuwcc7 205 1 These these DT cord-287123-ldkuwcc7 205 2 findings finding NNS cord-287123-ldkuwcc7 205 3 do do VBP cord-287123-ldkuwcc7 205 4 not not RB cord-287123-ldkuwcc7 205 5 support support VB cord-287123-ldkuwcc7 205 6 the the DT cord-287123-ldkuwcc7 205 7 original original JJ cord-287123-ldkuwcc7 205 8 report report NN cord-287123-ldkuwcc7 205 9 that that IN cord-287123-ldkuwcc7 205 10 LXA4 LXA4 NNP cord-287123-ldkuwcc7 205 11 could could MD cord-287123-ldkuwcc7 205 12 stimulate stimulate VB cord-287123-ldkuwcc7 205 13 GTPase GTPase NNP cord-287123-ldkuwcc7 205 14 activity activity NN cord-287123-ldkuwcc7 205 15 in in IN cord-287123-ldkuwcc7 205 16 FPR2-expressing fpr2-expresse VBG cord-287123-ldkuwcc7 205 17 CHO CHO NNP cord-287123-ldkuwcc7 205 18 cells cell NNS cord-287123-ldkuwcc7 205 19 [ [ -LRB- cord-287123-ldkuwcc7 205 20 74 74 CD cord-287123-ldkuwcc7 205 21 ] ] -RRB- cord-287123-ldkuwcc7 205 22 . . . cord-287123-ldkuwcc7 206 1 It -PRON- PRP cord-287123-ldkuwcc7 206 2 appears appear VBZ cord-287123-ldkuwcc7 206 3 difficult difficult JJ cord-287123-ldkuwcc7 206 4 to to TO cord-287123-ldkuwcc7 206 5 determine determine VB cord-287123-ldkuwcc7 206 6 the the DT cord-287123-ldkuwcc7 206 7 role role NN cord-287123-ldkuwcc7 206 8 of of IN cord-287123-ldkuwcc7 206 9 LXA4 LXA4 NNP cord-287123-ldkuwcc7 206 10 as as IN cord-287123-ldkuwcc7 206 11 an an DT cord-287123-ldkuwcc7 206 12 FPR2 FPR2 NNP cord-287123-ldkuwcc7 206 13 agonist agonist NN cord-287123-ldkuwcc7 206 14 without without IN cord-287123-ldkuwcc7 206 15 establishing establish VBG cord-287123-ldkuwcc7 206 16 a a DT cord-287123-ldkuwcc7 206 17 standard standard NN cord-287123-ldkuwcc7 206 18 in in IN cord-287123-ldkuwcc7 206 19 compound compound NN cord-287123-ldkuwcc7 206 20 preparation preparation NN cord-287123-ldkuwcc7 206 21 . . . cord-287123-ldkuwcc7 207 1 Moreover moreover RB cord-287123-ldkuwcc7 207 2 , , , cord-287123-ldkuwcc7 207 3 FPR2 FPR2 NNP cord-287123-ldkuwcc7 207 4 specific specific JJ cord-287123-ldkuwcc7 207 5 antagonists antagonist NNS cord-287123-ldkuwcc7 207 6 , , , cord-287123-ldkuwcc7 207 7 stereoselective stereoselective NNP cord-287123-ldkuwcc7 207 8 analogs analog NNS cord-287123-ldkuwcc7 207 9 , , , cord-287123-ldkuwcc7 207 10 antibodies antibody NNS cord-287123-ldkuwcc7 207 11 , , , cord-287123-ldkuwcc7 207 12 and and CC cord-287123-ldkuwcc7 207 13 transgenic transgenic JJ cord-287123-ldkuwcc7 207 14 approaches approach NNS cord-287123-ldkuwcc7 207 15 are be VBP cord-287123-ldkuwcc7 207 16 required require VBN cord-287123-ldkuwcc7 207 17 in in IN cord-287123-ldkuwcc7 207 18 further further JJ cord-287123-ldkuwcc7 207 19 studies study NNS cord-287123-ldkuwcc7 207 20 , , , cord-287123-ldkuwcc7 207 21 and and CC cord-287123-ldkuwcc7 207 22 the the DT cord-287123-ldkuwcc7 207 23 interaction interaction NN cord-287123-ldkuwcc7 207 24 of of IN cord-287123-ldkuwcc7 207 25 LXA4 LXA4 NNP cord-287123-ldkuwcc7 207 26 with with IN cord-287123-ldkuwcc7 207 27 other other JJ cord-287123-ldkuwcc7 207 28 receptors receptor NNS cord-287123-ldkuwcc7 207 29 such such JJ cord-287123-ldkuwcc7 207 30 as as IN cord-287123-ldkuwcc7 207 31 the the DT cord-287123-ldkuwcc7 207 32 cannabinoid cannabinoid NN cord-287123-ldkuwcc7 207 33 receptor receptor NN cord-287123-ldkuwcc7 207 34 CB1 CB1 NNP cord-287123-ldkuwcc7 207 35 [ [ -LRB- cord-287123-ldkuwcc7 207 36 157 157 CD cord-287123-ldkuwcc7 207 37 ] ] -RRB- cord-287123-ldkuwcc7 207 38 , , , cord-287123-ldkuwcc7 207 39 aryl aryl NN cord-287123-ldkuwcc7 207 40 hydrocarbon hydrocarbon NN cord-287123-ldkuwcc7 207 41 receptor receptor NN cord-287123-ldkuwcc7 207 42 ( ( -LRB- cord-287123-ldkuwcc7 207 43 AhR AhR NNP cord-287123-ldkuwcc7 207 44 ) ) -RRB- cord-287123-ldkuwcc7 207 45 [ [ -LRB- cord-287123-ldkuwcc7 207 46 158 158 CD cord-287123-ldkuwcc7 207 47 ] ] -RRB- cord-287123-ldkuwcc7 207 48 and and CC cord-287123-ldkuwcc7 207 49 estrogen estrogen NN cord-287123-ldkuwcc7 207 50 receptor receptor NN cord-287123-ldkuwcc7 207 51 [ [ -LRB- cord-287123-ldkuwcc7 207 52 159 159 CD cord-287123-ldkuwcc7 207 53 ] ] -RRB- cord-287123-ldkuwcc7 207 54 will will MD cord-287123-ldkuwcc7 207 55 have have VB cord-287123-ldkuwcc7 207 56 to to TO cord-287123-ldkuwcc7 207 57 be be VB cord-287123-ldkuwcc7 207 58 considered consider VBN cord-287123-ldkuwcc7 207 59 . . . cord-287123-ldkuwcc7 208 1 Resolvins Resolvins NNP cord-287123-ldkuwcc7 208 2 , , , cord-287123-ldkuwcc7 208 3 protectins protectin NNS cord-287123-ldkuwcc7 208 4 and and CC cord-287123-ldkuwcc7 208 5 maresins maresin NNS cord-287123-ldkuwcc7 208 6 are be VBP cord-287123-ldkuwcc7 208 7 novel novel JJ cord-287123-ldkuwcc7 208 8 pro pro JJ cord-287123-ldkuwcc7 208 9 - - JJ cord-287123-ldkuwcc7 208 10 resolving resolve VBG cord-287123-ldkuwcc7 208 11 mediators mediator NNS cord-287123-ldkuwcc7 208 12 that that WDT cord-287123-ldkuwcc7 208 13 are be VBP cord-287123-ldkuwcc7 208 14 biosynthesized biosynthesize VBN cord-287123-ldkuwcc7 208 15 from from IN cord-287123-ldkuwcc7 208 16 omega-3 omega-3 JJ cord-287123-ldkuwcc7 208 17 fatty fatty JJ cord-287123-ldkuwcc7 208 18 acids acid NNS cord-287123-ldkuwcc7 208 19 , , , cord-287123-ldkuwcc7 208 20 including include VBG cord-287123-ldkuwcc7 208 21 docosahexaenoic docosahexaenoic NNP cord-287123-ldkuwcc7 208 22 acid acid NNP cord-287123-ldkuwcc7 208 23 ( ( -LRB- cord-287123-ldkuwcc7 208 24 DHA DHA NNP cord-287123-ldkuwcc7 208 25 ) ) -RRB- cord-287123-ldkuwcc7 208 26 and and CC cord-287123-ldkuwcc7 208 27 eicosapentaenoic eicosapentaenoic JJ cord-287123-ldkuwcc7 208 28 acid acid NN cord-287123-ldkuwcc7 208 29 ( ( -LRB- cord-287123-ldkuwcc7 208 30 EPA EPA NNP cord-287123-ldkuwcc7 208 31 ) ) -RRB- cord-287123-ldkuwcc7 208 32 . . . cord-287123-ldkuwcc7 209 1 These these DT cord-287123-ldkuwcc7 209 2 lipid lipid NN cord-287123-ldkuwcc7 209 3 mediators mediator NNS cord-287123-ldkuwcc7 209 4 block block NN cord-287123-ldkuwcc7 209 5 neutrophil neutrophil NN cord-287123-ldkuwcc7 209 6 recruitment recruitment NN cord-287123-ldkuwcc7 209 7 , , , cord-287123-ldkuwcc7 209 8 promote promote VB cord-287123-ldkuwcc7 209 9 monocyte monocyte NNP cord-287123-ldkuwcc7 209 10 activation activation NN cord-287123-ldkuwcc7 209 11 , , , cord-287123-ldkuwcc7 209 12 and and CC cord-287123-ldkuwcc7 209 13 enhance enhance VB cord-287123-ldkuwcc7 209 14 macrophage macrophage NN cord-287123-ldkuwcc7 209 15 phagocytosis phagocytosis NN cord-287123-ldkuwcc7 209 16 . . . cord-287123-ldkuwcc7 210 1 Resolvin Resolvin NNP cord-287123-ldkuwcc7 210 2 D1 D1 NNP cord-287123-ldkuwcc7 210 3 , , , cord-287123-ldkuwcc7 210 4 a a DT cord-287123-ldkuwcc7 210 5 biosynthetic biosynthetic JJ cord-287123-ldkuwcc7 210 6 product product NN cord-287123-ldkuwcc7 210 7 from from IN cord-287123-ldkuwcc7 210 8 DHA DHA NNP cord-287123-ldkuwcc7 210 9 , , , cord-287123-ldkuwcc7 210 10 was be VBD cord-287123-ldkuwcc7 210 11 reported report VBN cord-287123-ldkuwcc7 210 12 to to TO cord-287123-ldkuwcc7 210 13 activate activate VB cord-287123-ldkuwcc7 210 14 FPR2 FPR2 NNP cord-287123-ldkuwcc7 210 15 and and CC cord-287123-ldkuwcc7 210 16 GPR32 GPR32 NNP cord-287123-ldkuwcc7 210 17 , , , cord-287123-ldkuwcc7 210 18 an an DT cord-287123-ldkuwcc7 210 19 orphan orphan NN cord-287123-ldkuwcc7 210 20 GPCR GPCR NNP cord-287123-ldkuwcc7 210 21 . . . cord-287123-ldkuwcc7 211 1 Similar similar JJ cord-287123-ldkuwcc7 211 2 with with IN cord-287123-ldkuwcc7 211 3 LXA4 LXA4 NNP cord-287123-ldkuwcc7 211 4 , , , cord-287123-ldkuwcc7 211 5 Resolvin Resolvin NNP cord-287123-ldkuwcc7 211 6 D1 D1 NNP cord-287123-ldkuwcc7 211 7 can can MD cord-287123-ldkuwcc7 211 8 not not RB cord-287123-ldkuwcc7 211 9 evoke evoke VB cord-287123-ldkuwcc7 211 10 calcium calcium NN cord-287123-ldkuwcc7 211 11 mobilization mobilization NN cord-287123-ldkuwcc7 211 12 through through IN cord-287123-ldkuwcc7 211 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 211 14 or or CC cord-287123-ldkuwcc7 211 15 GPR32 GPR32 NNP cord-287123-ldkuwcc7 211 16 . . . cord-287123-ldkuwcc7 212 1 The the DT cord-287123-ldkuwcc7 212 2 interaction interaction NN cord-287123-ldkuwcc7 212 3 of of IN cord-287123-ldkuwcc7 212 4 Resolvin Resolvin NNP cord-287123-ldkuwcc7 212 5 D1 D1 NNP cord-287123-ldkuwcc7 212 6 with with IN cord-287123-ldkuwcc7 212 7 these these DT cord-287123-ldkuwcc7 212 8 GPCRs gpcr NNS cord-287123-ldkuwcc7 212 9 was be VBD cord-287123-ldkuwcc7 212 10 examined examine VBN cord-287123-ldkuwcc7 212 11 by by IN cord-287123-ldkuwcc7 212 12 a a DT cord-287123-ldkuwcc7 212 13 GPCR GPCR NNP cord-287123-ldkuwcc7 212 14 - - HYPH cord-287123-ldkuwcc7 212 15 β β NN cord-287123-ldkuwcc7 212 16 - - HYPH cord-287123-ldkuwcc7 212 17 arrestin arrestin RB cord-287123-ldkuwcc7 212 18 - - HYPH cord-287123-ldkuwcc7 212 19 coupled couple VBN cord-287123-ldkuwcc7 212 20 system system NN cord-287123-ldkuwcc7 212 21 [ [ -LRB- cord-287123-ldkuwcc7 212 22 160 160 CD cord-287123-ldkuwcc7 212 23 ] ] -RRB- cord-287123-ldkuwcc7 212 24 . . . cord-287123-ldkuwcc7 213 1 Selective selective JJ cord-287123-ldkuwcc7 213 2 knock knock VBP cord-287123-ldkuwcc7 213 3 down down RP cord-287123-ldkuwcc7 213 4 or or CC cord-287123-ldkuwcc7 213 5 inhibition inhibition NN cord-287123-ldkuwcc7 213 6 of of IN cord-287123-ldkuwcc7 213 7 FPR2 FPR2 NNP cord-287123-ldkuwcc7 214 1 reduces reduce VBZ cord-287123-ldkuwcc7 214 2 the the DT cord-287123-ldkuwcc7 214 3 Resolvin Resolvin NNP cord-287123-ldkuwcc7 214 4 D1 D1 NNP cord-287123-ldkuwcc7 214 5 response response NN cord-287123-ldkuwcc7 214 6 , , , cord-287123-ldkuwcc7 214 7 such such JJ cord-287123-ldkuwcc7 214 8 as as IN cord-287123-ldkuwcc7 214 9 macrophage macrophage NN cord-287123-ldkuwcc7 214 10 phagocytosis phagocytosis NN cord-287123-ldkuwcc7 214 11 [ [ -LRB- cord-287123-ldkuwcc7 214 12 160 160 CD cord-287123-ldkuwcc7 214 13 ] ] -RRB- cord-287123-ldkuwcc7 214 14 and and CC cord-287123-ldkuwcc7 214 15 salivary salivary NN cord-287123-ldkuwcc7 214 16 epithelium epithelium NN cord-287123-ldkuwcc7 214 17 migration migration NN cord-287123-ldkuwcc7 214 18 [ [ -LRB- cord-287123-ldkuwcc7 214 19 161 161 CD cord-287123-ldkuwcc7 214 20 ] ] -RRB- cord-287123-ldkuwcc7 214 21 . . . cord-287123-ldkuwcc7 215 1 Resolvin Resolvin NNP cord-287123-ldkuwcc7 215 2 D1 D1 NNP cord-287123-ldkuwcc7 215 3 and and CC cord-287123-ldkuwcc7 215 4 FPR2 FPR2 NNP cord-287123-ldkuwcc7 215 5 are be VBP cord-287123-ldkuwcc7 215 6 also also RB cord-287123-ldkuwcc7 215 7 implicated implicate VBN cord-287123-ldkuwcc7 215 8 in in IN cord-287123-ldkuwcc7 215 9 pulmonary pulmonary JJ cord-287123-ldkuwcc7 215 10 inflammation inflammation NN cord-287123-ldkuwcc7 215 11 [ [ -LRB- cord-287123-ldkuwcc7 215 12 162 162 CD cord-287123-ldkuwcc7 215 13 ] ] -RRB- cord-287123-ldkuwcc7 215 14 and and CC cord-287123-ldkuwcc7 215 15 obesity obesity NN cord-287123-ldkuwcc7 215 16 [ [ -LRB- cord-287123-ldkuwcc7 215 17 163 163 CD cord-287123-ldkuwcc7 215 18 ] ] -RRB- cord-287123-ldkuwcc7 215 19 . . . cord-287123-ldkuwcc7 216 1 Oxidized oxidize VBN cord-287123-ldkuwcc7 216 2 low low JJ cord-287123-ldkuwcc7 216 3 - - HYPH cord-287123-ldkuwcc7 216 4 density density NN cord-287123-ldkuwcc7 216 5 lipoprotein lipoprotein NN cord-287123-ldkuwcc7 216 6 ( ( -LRB- cord-287123-ldkuwcc7 216 7 oxLDL oxLDL NNP cord-287123-ldkuwcc7 216 8 ) ) -RRB- cord-287123-ldkuwcc7 216 9 , , , cord-287123-ldkuwcc7 216 10 an an DT cord-287123-ldkuwcc7 216 11 atherogenesis atherogenesis NN cord-287123-ldkuwcc7 216 12 associated associate VBN cord-287123-ldkuwcc7 216 13 molecule molecule NN cord-287123-ldkuwcc7 216 14 , , , cord-287123-ldkuwcc7 216 15 was be VBD cord-287123-ldkuwcc7 216 16 recently recently RB cord-287123-ldkuwcc7 216 17 found find VBN cord-287123-ldkuwcc7 216 18 to to TO cord-287123-ldkuwcc7 216 19 stimulate stimulate VB cord-287123-ldkuwcc7 216 20 macrophages macrophage NNS cord-287123-ldkuwcc7 216 21 via via IN cord-287123-ldkuwcc7 216 22 FPR2 FPR2 NNP cord-287123-ldkuwcc7 216 23 signaling signal VBG cord-287123-ldkuwcc7 216 24 [ [ -LRB- cord-287123-ldkuwcc7 216 25 164 164 CD cord-287123-ldkuwcc7 216 26 ] ] -RRB- cord-287123-ldkuwcc7 216 27 . . . cord-287123-ldkuwcc7 217 1 The the DT cord-287123-ldkuwcc7 217 2 oxLDL oxldl JJ cord-287123-ldkuwcc7 217 3 - - HYPH cord-287123-ldkuwcc7 217 4 induced induce VBN cord-287123-ldkuwcc7 217 5 foam foam NN cord-287123-ldkuwcc7 217 6 cell cell NN cord-287123-ldkuwcc7 217 7 formation formation NN cord-287123-ldkuwcc7 217 8 and and CC cord-287123-ldkuwcc7 217 9 TNF TNF NNP cord-287123-ldkuwcc7 217 10 - - HYPH cord-287123-ldkuwcc7 217 11 α α NN cord-287123-ldkuwcc7 217 12 production production NN cord-287123-ldkuwcc7 217 13 could could MD cord-287123-ldkuwcc7 217 14 be be VB cord-287123-ldkuwcc7 217 15 inhibited inhibit VBN cord-287123-ldkuwcc7 217 16 by by IN cord-287123-ldkuwcc7 217 17 an an DT cord-287123-ldkuwcc7 217 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 217 19 antagonist antagonist NN cord-287123-ldkuwcc7 217 20 WRW WRW NNP cord-287123-ldkuwcc7 217 21 4 4 CD cord-287123-ldkuwcc7 217 22 , , , cord-287123-ldkuwcc7 217 23 but but CC cord-287123-ldkuwcc7 217 24 not not RB cord-287123-ldkuwcc7 217 25 affected affect VBN cord-287123-ldkuwcc7 217 26 by by IN cord-287123-ldkuwcc7 217 27 an an DT cord-287123-ldkuwcc7 217 28 FPR1 FPR1 NNP cord-287123-ldkuwcc7 217 29 antagonist antagonist NN cord-287123-ldkuwcc7 217 30 . . . cord-287123-ldkuwcc7 218 1 In in IN cord-287123-ldkuwcc7 218 2 FPR2-expressing fpr2-expresse VBG cord-287123-ldkuwcc7 218 3 RBL-2H3 rbl-2h3 NN cord-287123-ldkuwcc7 218 4 cells cell NNS cord-287123-ldkuwcc7 218 5 , , , cord-287123-ldkuwcc7 218 6 oxLDL oxldl NN cord-287123-ldkuwcc7 218 7 also also RB cord-287123-ldkuwcc7 218 8 stimulated stimulate VBD cord-287123-ldkuwcc7 218 9 significant significant JJ cord-287123-ldkuwcc7 218 10 calcium calcium NN cord-287123-ldkuwcc7 218 11 mobilization mobilization NN cord-287123-ldkuwcc7 218 12 and and CC cord-287123-ldkuwcc7 218 13 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 218 14 [ [ -LRB- cord-287123-ldkuwcc7 218 15 164 164 CD cord-287123-ldkuwcc7 218 16 ] ] -RRB- cord-287123-ldkuwcc7 218 17 . . . cord-287123-ldkuwcc7 219 1 In in IN cord-287123-ldkuwcc7 219 2 another another DT cord-287123-ldkuwcc7 219 3 study study NN cord-287123-ldkuwcc7 219 4 , , , cord-287123-ldkuwcc7 219 5 the the DT cord-287123-ldkuwcc7 219 6 mimetic mimetic JJ cord-287123-ldkuwcc7 219 7 peptide peptide NN cord-287123-ldkuwcc7 219 8 L-37pA l-37pa NN cord-287123-ldkuwcc7 219 9 ( ( -LRB- cord-287123-ldkuwcc7 219 10 Table table NN cord-287123-ldkuwcc7 219 11 1 1 CD cord-287123-ldkuwcc7 219 12 ) ) -RRB- cord-287123-ldkuwcc7 219 13 of of IN cord-287123-ldkuwcc7 219 14 apoA apoA NNP cord-287123-ldkuwcc7 219 15 - - : cord-287123-ldkuwcc7 219 16 I I NNP cord-287123-ldkuwcc7 219 17 , , , cord-287123-ldkuwcc7 219 18 a a DT cord-287123-ldkuwcc7 219 19 major major JJ cord-287123-ldkuwcc7 219 20 component component NN cord-287123-ldkuwcc7 219 21 of of IN cord-287123-ldkuwcc7 219 22 circulating circulate VBG cord-287123-ldkuwcc7 219 23 high high JJ cord-287123-ldkuwcc7 219 24 - - HYPH cord-287123-ldkuwcc7 219 25 density density NN cord-287123-ldkuwcc7 219 26 lipoprotein lipoprotein NN cord-287123-ldkuwcc7 219 27 ( ( -LRB- cord-287123-ldkuwcc7 219 28 HDL HDL NNP cord-287123-ldkuwcc7 219 29 ) ) -RRB- cord-287123-ldkuwcc7 219 30 , , , cord-287123-ldkuwcc7 219 31 was be VBD cord-287123-ldkuwcc7 219 32 reported report VBN cord-287123-ldkuwcc7 219 33 to to TO cord-287123-ldkuwcc7 219 34 induce induce VB cord-287123-ldkuwcc7 219 35 calcium calcium NN cord-287123-ldkuwcc7 219 36 flux flux NN cord-287123-ldkuwcc7 219 37 and and CC cord-287123-ldkuwcc7 219 38 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 219 39 through through IN cord-287123-ldkuwcc7 219 40 FPR2 FPR2 NNP cord-287123-ldkuwcc7 219 41 . . . cord-287123-ldkuwcc7 220 1 L-37pA L-37pA NNP cord-287123-ldkuwcc7 220 2 is be VBZ cord-287123-ldkuwcc7 220 3 probably probably RB cord-287123-ldkuwcc7 220 4 a a DT cord-287123-ldkuwcc7 220 5 biased biased JJ cord-287123-ldkuwcc7 220 6 agonist agonist NN cord-287123-ldkuwcc7 220 7 of of IN cord-287123-ldkuwcc7 220 8 FPR2 FPR2 NNP cord-287123-ldkuwcc7 220 9 as as IN cord-287123-ldkuwcc7 220 10 it -PRON- PRP cord-287123-ldkuwcc7 220 11 fails fail VBZ cord-287123-ldkuwcc7 220 12 to to TO cord-287123-ldkuwcc7 220 13 induce induce VB cord-287123-ldkuwcc7 220 14 superoxide superoxide JJ cord-287123-ldkuwcc7 220 15 generation generation NN cord-287123-ldkuwcc7 220 16 in in IN cord-287123-ldkuwcc7 220 17 human human JJ cord-287123-ldkuwcc7 220 18 neutrophils neutrophil NNS cord-287123-ldkuwcc7 220 19 at at IN cord-287123-ldkuwcc7 220 20 a a DT cord-287123-ldkuwcc7 220 21 concentration concentration NN cord-287123-ldkuwcc7 220 22 up up IN cord-287123-ldkuwcc7 220 23 to to TO cord-287123-ldkuwcc7 220 24 20 20 CD cord-287123-ldkuwcc7 220 25 µM µm XX cord-287123-ldkuwcc7 220 26 [ [ -LRB- cord-287123-ldkuwcc7 220 27 71 71 CD cord-287123-ldkuwcc7 220 28 ] ] -RRB- cord-287123-ldkuwcc7 220 29 . . . cord-287123-ldkuwcc7 221 1 D-37pA D-37pA NNP cord-287123-ldkuwcc7 221 2 , , , cord-287123-ldkuwcc7 221 3 the the DT cord-287123-ldkuwcc7 221 4 D d NN cord-287123-ldkuwcc7 221 5 - - HYPH cord-287123-ldkuwcc7 221 6 stereoisomer stereoisomer NN cord-287123-ldkuwcc7 221 7 of of IN cord-287123-ldkuwcc7 221 8 L-37pA l-37pa NN cord-287123-ldkuwcc7 221 9 , , , cord-287123-ldkuwcc7 221 10 blocks block VBZ cord-287123-ldkuwcc7 221 11 L-37pA l-37pa NN cord-287123-ldkuwcc7 221 12 signaling signal VBG cord-287123-ldkuwcc7 221 13 and and CC cord-287123-ldkuwcc7 221 14 induces induce VBZ cord-287123-ldkuwcc7 221 15 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 221 16 but but CC cord-287123-ldkuwcc7 221 17 not not RB cord-287123-ldkuwcc7 221 18 calcium calcium NN cord-287123-ldkuwcc7 221 19 flux flux NN cord-287123-ldkuwcc7 221 20 . . . cord-287123-ldkuwcc7 222 1 It -PRON- PRP cord-287123-ldkuwcc7 222 2 is be VBZ cord-287123-ldkuwcc7 222 3 unclear unclear JJ cord-287123-ldkuwcc7 222 4 whether whether IN cord-287123-ldkuwcc7 222 5 D-37pA d-37pa NN cord-287123-ldkuwcc7 222 6 is be VBZ cord-287123-ldkuwcc7 222 7 an an DT cord-287123-ldkuwcc7 222 8 anti anti JJ cord-287123-ldkuwcc7 222 9 - - JJ cord-287123-ldkuwcc7 222 10 inflammatory inflammatory JJ cord-287123-ldkuwcc7 222 11 antagonist antagonist NN cord-287123-ldkuwcc7 222 12 of of IN cord-287123-ldkuwcc7 222 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 222 14 . . . cord-287123-ldkuwcc7 223 1 It -PRON- PRP cord-287123-ldkuwcc7 223 2 has have VBZ cord-287123-ldkuwcc7 223 3 been be VBN cord-287123-ldkuwcc7 223 4 noted note VBN cord-287123-ldkuwcc7 223 5 that that IN cord-287123-ldkuwcc7 223 6 apoA apoa NN cord-287123-ldkuwcc7 223 7 - - : cord-287123-ldkuwcc7 223 8 I -PRON- PRP cord-287123-ldkuwcc7 223 9 itself -PRON- PRP cord-287123-ldkuwcc7 223 10 and and CC cord-287123-ldkuwcc7 223 11 apoE apoE NNS cord-287123-ldkuwcc7 223 12 , , , cord-287123-ldkuwcc7 223 13 another another DT cord-287123-ldkuwcc7 223 14 important important JJ cord-287123-ldkuwcc7 223 15 component component NN cord-287123-ldkuwcc7 223 16 of of IN cord-287123-ldkuwcc7 223 17 HDL HDL NNP cord-287123-ldkuwcc7 223 18 , , , cord-287123-ldkuwcc7 223 19 are be VBP cord-287123-ldkuwcc7 223 20 described describe VBN cord-287123-ldkuwcc7 223 21 as as IN cord-287123-ldkuwcc7 223 22 being be VBG cord-287123-ldkuwcc7 223 23 anti anti JJ cord-287123-ldkuwcc7 223 24 - - JJ cord-287123-ldkuwcc7 223 25 inflammatory inflammatory JJ cord-287123-ldkuwcc7 223 26 , , , cord-287123-ldkuwcc7 223 27 as as IN cord-287123-ldkuwcc7 223 28 they -PRON- PRP cord-287123-ldkuwcc7 223 29 suppress suppress VBP cord-287123-ldkuwcc7 223 30 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 223 31 of of IN cord-287123-ldkuwcc7 223 32 leukocytes leukocyte NNS cord-287123-ldkuwcc7 223 33 in in IN cord-287123-ldkuwcc7 223 34 the the DT cord-287123-ldkuwcc7 223 35 airway airway NN cord-287123-ldkuwcc7 223 36 . . . cord-287123-ldkuwcc7 224 1 Currently currently RB cord-287123-ldkuwcc7 224 2 , , , cord-287123-ldkuwcc7 224 3 there there EX cord-287123-ldkuwcc7 224 4 has have VBZ cord-287123-ldkuwcc7 224 5 been be VBN cord-287123-ldkuwcc7 224 6 an an DT cord-287123-ldkuwcc7 224 7 increasing increase VBG cord-287123-ldkuwcc7 224 8 interest interest NN cord-287123-ldkuwcc7 224 9 in in IN cord-287123-ldkuwcc7 224 10 a a DT cord-287123-ldkuwcc7 224 11 group group NN cord-287123-ldkuwcc7 224 12 of of IN cord-287123-ldkuwcc7 224 13 newly newly RB cord-287123-ldkuwcc7 224 14 emerging emerge VBG cord-287123-ldkuwcc7 224 15 molecules molecule NNS cord-287123-ldkuwcc7 224 16 that that WDT cord-287123-ldkuwcc7 224 17 modulate modulate VBP cord-287123-ldkuwcc7 224 18 GPCR GPCR NNP cord-287123-ldkuwcc7 224 19 activity activity NN cord-287123-ldkuwcc7 224 20 by by IN cord-287123-ldkuwcc7 224 21 entirely entirely RB cord-287123-ldkuwcc7 224 22 novel novel JJ cord-287123-ldkuwcc7 224 23 mechanisms mechanism NNS cord-287123-ldkuwcc7 224 24 . . . cord-287123-ldkuwcc7 225 1 These these DT cord-287123-ldkuwcc7 225 2 molecules molecule NNS cord-287123-ldkuwcc7 225 3 , , , cord-287123-ldkuwcc7 225 4 known know VBN cord-287123-ldkuwcc7 225 5 as as IN cord-287123-ldkuwcc7 225 6 pepducins pepducins NNP cord-287123-ldkuwcc7 225 7 , , , cord-287123-ldkuwcc7 225 8 comprise comprise VBP cord-287123-ldkuwcc7 225 9 a a DT cord-287123-ldkuwcc7 225 10 lipid lipid NN cord-287123-ldkuwcc7 225 11 moiety moiety NN cord-287123-ldkuwcc7 225 12 conjugated conjugate VBN cord-287123-ldkuwcc7 225 13 with with IN cord-287123-ldkuwcc7 225 14 a a DT cord-287123-ldkuwcc7 225 15 peptide peptide NN cord-287123-ldkuwcc7 225 16 that that WDT cord-287123-ldkuwcc7 225 17 is be VBZ cord-287123-ldkuwcc7 225 18 derived derive VBN cord-287123-ldkuwcc7 225 19 from from IN cord-287123-ldkuwcc7 225 20 a a DT cord-287123-ldkuwcc7 225 21 sequence sequence NN cord-287123-ldkuwcc7 225 22 of of IN cord-287123-ldkuwcc7 225 23 the the DT cord-287123-ldkuwcc7 225 24 cytoplasmic cytoplasmic JJ cord-287123-ldkuwcc7 225 25 loops loop NNS cord-287123-ldkuwcc7 225 26 or or CC cord-287123-ldkuwcc7 225 27 the the DT cord-287123-ldkuwcc7 225 28 C c NN cord-287123-ldkuwcc7 225 29 - - HYPH cord-287123-ldkuwcc7 225 30 terminal terminal NN cord-287123-ldkuwcc7 225 31 tail tail NN cord-287123-ldkuwcc7 225 32 of of IN cord-287123-ldkuwcc7 225 33 the the DT cord-287123-ldkuwcc7 225 34 target target NN cord-287123-ldkuwcc7 225 35 GPCR GPCR NNP cord-287123-ldkuwcc7 225 36 [ [ -LRB- cord-287123-ldkuwcc7 225 37 165 165 CD cord-287123-ldkuwcc7 225 38 , , , cord-287123-ldkuwcc7 225 39 166 166 CD cord-287123-ldkuwcc7 225 40 ] ] -RRB- cord-287123-ldkuwcc7 225 41 . . . cord-287123-ldkuwcc7 226 1 With with IN cord-287123-ldkuwcc7 226 2 the the DT cord-287123-ldkuwcc7 226 3 facilitation facilitation NN cord-287123-ldkuwcc7 226 4 of of IN cord-287123-ldkuwcc7 226 5 the the DT cord-287123-ldkuwcc7 226 6 lipid lipid NN cord-287123-ldkuwcc7 226 7 moiety moiety NN cord-287123-ldkuwcc7 226 8 , , , cord-287123-ldkuwcc7 226 9 pepducins pepducins NNP cord-287123-ldkuwcc7 226 10 are be VBP cord-287123-ldkuwcc7 226 11 thought think VBN cord-287123-ldkuwcc7 226 12 to to TO cord-287123-ldkuwcc7 226 13 pass pass VB cord-287123-ldkuwcc7 226 14 across across IN cord-287123-ldkuwcc7 226 15 plasma plasma NN cord-287123-ldkuwcc7 226 16 membrane membrane NN cord-287123-ldkuwcc7 226 17 and and CC cord-287123-ldkuwcc7 226 18 anchor anchor NN cord-287123-ldkuwcc7 226 19 in in IN cord-287123-ldkuwcc7 226 20 the the DT cord-287123-ldkuwcc7 226 21 cytosolic cytosolic JJ cord-287123-ldkuwcc7 226 22 interface interface NN cord-287123-ldkuwcc7 226 23 to to TO cord-287123-ldkuwcc7 226 24 activate activate VB cord-287123-ldkuwcc7 226 25 or or CC cord-287123-ldkuwcc7 226 26 inhibit inhibit VB cord-287123-ldkuwcc7 226 27 signaling signal VBG cord-287123-ldkuwcc7 226 28 of of IN cord-287123-ldkuwcc7 226 29 receptors receptor NNS cord-287123-ldkuwcc7 226 30 [ [ -LRB- cord-287123-ldkuwcc7 226 31 166 166 CD cord-287123-ldkuwcc7 226 32 ] ] -RRB- cord-287123-ldkuwcc7 226 33 . . . cord-287123-ldkuwcc7 227 1 These these DT cord-287123-ldkuwcc7 227 2 lipidated lipidate VBN cord-287123-ldkuwcc7 227 3 peptides peptide NNS cord-287123-ldkuwcc7 227 4 have have VBP cord-287123-ldkuwcc7 227 5 been be VBN cord-287123-ldkuwcc7 227 6 proposed propose VBN cord-287123-ldkuwcc7 227 7 as as IN cord-287123-ldkuwcc7 227 8 allosteric allosteric JJ cord-287123-ldkuwcc7 227 9 modulators modulator NNS cord-287123-ldkuwcc7 227 10 , , , cord-287123-ldkuwcc7 227 11 because because IN cord-287123-ldkuwcc7 227 12 the the DT cord-287123-ldkuwcc7 227 13 binding bind VBG cord-287123-ldkuwcc7 227 14 sites site NNS cord-287123-ldkuwcc7 227 15 and and CC cord-287123-ldkuwcc7 227 16 action action NN cord-287123-ldkuwcc7 227 17 modes mode NNS cord-287123-ldkuwcc7 227 18 are be VBP cord-287123-ldkuwcc7 227 19 different different JJ cord-287123-ldkuwcc7 227 20 from from IN cord-287123-ldkuwcc7 227 21 those those DT cord-287123-ldkuwcc7 227 22 of of IN cord-287123-ldkuwcc7 227 23 conventional conventional JJ cord-287123-ldkuwcc7 227 24 ligands ligand NNS cord-287123-ldkuwcc7 227 25 that that WDT cord-287123-ldkuwcc7 227 26 generally generally RB cord-287123-ldkuwcc7 227 27 interact interact VBP cord-287123-ldkuwcc7 227 28 with with IN cord-287123-ldkuwcc7 227 29 extracellular extracellular JJ cord-287123-ldkuwcc7 227 30 domains domain NNS cord-287123-ldkuwcc7 227 31 of of IN cord-287123-ldkuwcc7 227 32 receptors receptor NNS cord-287123-ldkuwcc7 227 33 [ [ -LRB- cord-287123-ldkuwcc7 227 34 5 5 CD cord-287123-ldkuwcc7 227 35 , , , cord-287123-ldkuwcc7 227 36 166 166 CD cord-287123-ldkuwcc7 227 37 ] ] -RRB- cord-287123-ldkuwcc7 227 38 . . . cord-287123-ldkuwcc7 228 1 Despite despite IN cord-287123-ldkuwcc7 228 2 that that DT cord-287123-ldkuwcc7 228 3 the the DT cord-287123-ldkuwcc7 228 4 ' ' `` cord-287123-ldkuwcc7 228 5 allosteric allosteric JJ cord-287123-ldkuwcc7 228 6 modulation modulation NN cord-287123-ldkuwcc7 228 7 ' ' '' cord-287123-ldkuwcc7 228 8 mechanism mechanism NN cord-287123-ldkuwcc7 228 9 is be VBZ cord-287123-ldkuwcc7 228 10 not not RB cord-287123-ldkuwcc7 228 11 yet yet RB cord-287123-ldkuwcc7 228 12 fully fully RB cord-287123-ldkuwcc7 228 13 clarified clarify VBN cord-287123-ldkuwcc7 228 14 , , , cord-287123-ldkuwcc7 228 15 several several JJ cord-287123-ldkuwcc7 228 16 receptor receptor NN cord-287123-ldkuwcc7 228 17 - - HYPH cord-287123-ldkuwcc7 228 18 specific specific JJ cord-287123-ldkuwcc7 228 19 pepducins pepducin NNS cord-287123-ldkuwcc7 228 20 have have VBP cord-287123-ldkuwcc7 228 21 been be VBN cord-287123-ldkuwcc7 228 22 identified identify VBN cord-287123-ldkuwcc7 228 23 , , , cord-287123-ldkuwcc7 228 24 including include VBG cord-287123-ldkuwcc7 228 25 an an DT cord-287123-ldkuwcc7 228 26 FPR2 FPR2 NNP cord-287123-ldkuwcc7 228 27 agonistic agonistic JJ cord-287123-ldkuwcc7 228 28 pepducin pepducin NNS cord-287123-ldkuwcc7 228 29 F2Pal16 f2pal16 NN cord-287123-ldkuwcc7 228 30 . . . cord-287123-ldkuwcc7 229 1 F2Pal16 f2pal16 NN cord-287123-ldkuwcc7 229 2 is be VBZ cord-287123-ldkuwcc7 229 3 composed compose VBN cord-287123-ldkuwcc7 229 4 of of IN cord-287123-ldkuwcc7 229 5 palmitic palmitic JJ cord-287123-ldkuwcc7 229 6 acid acid NN cord-287123-ldkuwcc7 229 7 linked link VBN cord-287123-ldkuwcc7 229 8 to to IN cord-287123-ldkuwcc7 229 9 a a DT cord-287123-ldkuwcc7 229 10 16-mer 16-mer CD cord-287123-ldkuwcc7 229 11 peptide peptide NN cord-287123-ldkuwcc7 229 12 with with IN cord-287123-ldkuwcc7 229 13 sequence sequence NN cord-287123-ldkuwcc7 229 14 identical identical JJ cord-287123-ldkuwcc7 229 15 to to IN cord-287123-ldkuwcc7 229 16 the the DT cord-287123-ldkuwcc7 229 17 third third JJ cord-287123-ldkuwcc7 229 18 intracellular intracellular JJ cord-287123-ldkuwcc7 229 19 loop loop NN cord-287123-ldkuwcc7 229 20 of of IN cord-287123-ldkuwcc7 229 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 229 22 . . . cord-287123-ldkuwcc7 230 1 F2Pal16 F2Pal16 NNP cord-287123-ldkuwcc7 230 2 was be VBD cord-287123-ldkuwcc7 230 3 found find VBN cord-287123-ldkuwcc7 230 4 to to TO cord-287123-ldkuwcc7 230 5 activate activate VB cord-287123-ldkuwcc7 230 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 230 7 , , , cord-287123-ldkuwcc7 230 8 like like IN cord-287123-ldkuwcc7 230 9 conventional conventional JJ cord-287123-ldkuwcc7 230 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 230 11 agonists agonist NNS cord-287123-ldkuwcc7 230 12 , , , cord-287123-ldkuwcc7 230 13 in in IN cord-287123-ldkuwcc7 230 14 phagocytes phagocyte NNS cord-287123-ldkuwcc7 230 15 and and CC cord-287123-ldkuwcc7 230 16 stably stably RB cord-287123-ldkuwcc7 230 17 transfected transfecte VBN cord-287123-ldkuwcc7 230 18 HL-60 HL-60 NNP cord-287123-ldkuwcc7 230 19 cells cell NNS cord-287123-ldkuwcc7 230 20 [ [ -LRB- cord-287123-ldkuwcc7 230 21 72 72 CD cord-287123-ldkuwcc7 230 22 , , , cord-287123-ldkuwcc7 230 23 73 73 CD cord-287123-ldkuwcc7 230 24 ] ] -RRB- cord-287123-ldkuwcc7 230 25 . . . cord-287123-ldkuwcc7 231 1 A a DT cord-287123-ldkuwcc7 231 2 shorter short JJR cord-287123-ldkuwcc7 231 3 variant variant JJ cord-287123-ldkuwcc7 231 4 F2Pal10 F2Pal10 NNP cord-287123-ldkuwcc7 231 5 , , , cord-287123-ldkuwcc7 231 6 with with IN cord-287123-ldkuwcc7 231 7 higher high JJR cord-287123-ldkuwcc7 231 8 potency potency NN cord-287123-ldkuwcc7 231 9 compared compare VBN cord-287123-ldkuwcc7 231 10 to to IN cord-287123-ldkuwcc7 231 11 F2Pal16 F2Pal16 NNP cord-287123-ldkuwcc7 231 12 , , , cord-287123-ldkuwcc7 231 13 was be VBD cord-287123-ldkuwcc7 231 14 shown show VBN cord-287123-ldkuwcc7 231 15 to to TO cord-287123-ldkuwcc7 231 16 act act VB cord-287123-ldkuwcc7 231 17 as as IN cord-287123-ldkuwcc7 231 18 a a DT cord-287123-ldkuwcc7 231 19 partial partial JJ cord-287123-ldkuwcc7 231 20 agonist agonist NN cord-287123-ldkuwcc7 231 21 for for IN cord-287123-ldkuwcc7 231 22 direct direct JJ cord-287123-ldkuwcc7 231 23 activation activation NN cord-287123-ldkuwcc7 231 24 of of IN cord-287123-ldkuwcc7 231 25 FPR2 FPR2 NNP cord-287123-ldkuwcc7 231 26 but but CC cord-287123-ldkuwcc7 231 27 as as IN cord-287123-ldkuwcc7 231 28 a a DT cord-287123-ldkuwcc7 231 29 full full JJ cord-287123-ldkuwcc7 231 30 agonist agonist NN cord-287123-ldkuwcc7 231 31 for for IN cord-287123-ldkuwcc7 231 32 cross cross JJ cord-287123-ldkuwcc7 231 33 - - NN cord-287123-ldkuwcc7 231 34 talk talk NN cord-287123-ldkuwcc7 231 35 triggered trigger VBN cord-287123-ldkuwcc7 231 36 hPFR2 hpfr2 NN cord-287123-ldkuwcc7 231 37 reactivation reactivation NN cord-287123-ldkuwcc7 231 38 generated generate VBN cord-287123-ldkuwcc7 231 39 by by IN cord-287123-ldkuwcc7 231 40 PAF PAF NNP cord-287123-ldkuwcc7 231 41 receptor receptor NN cord-287123-ldkuwcc7 231 42 and and CC cord-287123-ldkuwcc7 231 43 ATP ATP NNP cord-287123-ldkuwcc7 231 44 receptor receptor NN cord-287123-ldkuwcc7 231 45 ( ( -LRB- cord-287123-ldkuwcc7 231 46 P2Y2R P2Y2R NNP cord-287123-ldkuwcc7 231 47 ) ) -RRB- cord-287123-ldkuwcc7 231 48 [ [ -LRB- cord-287123-ldkuwcc7 231 49 73 73 CD cord-287123-ldkuwcc7 231 50 , , , cord-287123-ldkuwcc7 231 51 167 167 CD cord-287123-ldkuwcc7 231 52 ] ] -RRB- cord-287123-ldkuwcc7 231 53 . . . cord-287123-ldkuwcc7 232 1 It -PRON- PRP cord-287123-ldkuwcc7 232 2 is be VBZ cord-287123-ldkuwcc7 232 3 noteworthy noteworthy JJ cord-287123-ldkuwcc7 232 4 that that IN cord-287123-ldkuwcc7 232 5 pepducins pepducin NNS cord-287123-ldkuwcc7 232 6 are be VBP cord-287123-ldkuwcc7 232 7 not not RB cord-287123-ldkuwcc7 232 8 always always RB cord-287123-ldkuwcc7 232 9 specific specific JJ cord-287123-ldkuwcc7 232 10 for for IN cord-287123-ldkuwcc7 232 11 their -PRON- PRP$ cord-287123-ldkuwcc7 232 12 designated designate VBN cord-287123-ldkuwcc7 232 13 target target NN cord-287123-ldkuwcc7 232 14 receptor receptor NN cord-287123-ldkuwcc7 232 15 . . . cord-287123-ldkuwcc7 233 1 For for IN cord-287123-ldkuwcc7 233 2 example example NN cord-287123-ldkuwcc7 233 3 , , , cord-287123-ldkuwcc7 233 4 the the DT cord-287123-ldkuwcc7 233 5 pepducins pepducins NNP cord-287123-ldkuwcc7 233 6 P2Y2PalIC2 p2y2palic2 NN cord-287123-ldkuwcc7 233 7 and and CC cord-287123-ldkuwcc7 233 8 P2Y2PalIC3 P2Y2PalIC3 NNP cord-287123-ldkuwcc7 233 9 that that WDT cord-287123-ldkuwcc7 233 10 contain contain VBP cord-287123-ldkuwcc7 233 11 sequences sequence NNS cord-287123-ldkuwcc7 233 12 of of IN cord-287123-ldkuwcc7 233 13 the the DT cord-287123-ldkuwcc7 233 14 second second JJ cord-287123-ldkuwcc7 233 15 and and CC cord-287123-ldkuwcc7 233 16 third third JJ cord-287123-ldkuwcc7 233 17 intracellular intracellular JJ cord-287123-ldkuwcc7 233 18 loops loop NNS cord-287123-ldkuwcc7 233 19 of of IN cord-287123-ldkuwcc7 233 20 P2Y2R P2Y2R NNP cord-287123-ldkuwcc7 233 21 , , , cord-287123-ldkuwcc7 233 22 were be VBD cord-287123-ldkuwcc7 233 23 identified identify VBN cord-287123-ldkuwcc7 233 24 to to TO cord-287123-ldkuwcc7 233 25 be be VB cord-287123-ldkuwcc7 233 26 FPR2 FPR2 NNP cord-287123-ldkuwcc7 233 27 agonists agonist NNS cord-287123-ldkuwcc7 233 28 and and CC cord-287123-ldkuwcc7 233 29 could could MD cord-287123-ldkuwcc7 233 30 activate activate VB cord-287123-ldkuwcc7 233 31 neutrophils neutrophil NNS cord-287123-ldkuwcc7 233 32 with with IN cord-287123-ldkuwcc7 233 33 responses response NNS cord-287123-ldkuwcc7 233 34 inhibited inhibit VBN cord-287123-ldkuwcc7 233 35 by by IN cord-287123-ldkuwcc7 233 36 FPR2 FPR2 NNP cord-287123-ldkuwcc7 233 37 antagonists antagonist NNS cord-287123-ldkuwcc7 233 38 but but CC cord-287123-ldkuwcc7 233 39 not not RB cord-287123-ldkuwcc7 233 40 P2Y2R P2Y2R NNP cord-287123-ldkuwcc7 233 41 antagonist antagonist NN cord-287123-ldkuwcc7 233 42 [ [ -LRB- cord-287123-ldkuwcc7 233 43 168 168 CD cord-287123-ldkuwcc7 233 44 ] ] -RRB- cord-287123-ldkuwcc7 233 45 . . . cord-287123-ldkuwcc7 234 1 In in IN cord-287123-ldkuwcc7 234 2 a a DT cord-287123-ldkuwcc7 234 3 recent recent JJ cord-287123-ldkuwcc7 234 4 study study NN cord-287123-ldkuwcc7 234 5 , , , cord-287123-ldkuwcc7 234 6 a a DT cord-287123-ldkuwcc7 234 7 pepducin pepducin NNS cord-287123-ldkuwcc7 234 8 ( ( -LRB- cord-287123-ldkuwcc7 234 9 ATI-2341 ATI-2341 NNP cord-287123-ldkuwcc7 234 10 ) ) -RRB- cord-287123-ldkuwcc7 234 11 designed design VBN cord-287123-ldkuwcc7 234 12 for for IN cord-287123-ldkuwcc7 234 13 CXCR4 CXCR4 NNS cord-287123-ldkuwcc7 234 14 , , , cord-287123-ldkuwcc7 234 15 a a DT cord-287123-ldkuwcc7 234 16 chemokine chemokine NN cord-287123-ldkuwcc7 234 17 receptor receptor NN cord-287123-ldkuwcc7 234 18 , , , cord-287123-ldkuwcc7 234 19 was be VBD cord-287123-ldkuwcc7 234 20 found find VBN cord-287123-ldkuwcc7 234 21 to to TO cord-287123-ldkuwcc7 234 22 activate activate VB cord-287123-ldkuwcc7 234 23 neutrophil neutrophil NN cord-287123-ldkuwcc7 234 24 functions function NNS cord-287123-ldkuwcc7 234 25 through through IN cord-287123-ldkuwcc7 234 26 FPR2-dependent fpr2-dependent NN cord-287123-ldkuwcc7 234 27 signaling signal VBG cord-287123-ldkuwcc7 234 28 [ [ -LRB- cord-287123-ldkuwcc7 234 29 169 169 CD cord-287123-ldkuwcc7 234 30 ] ] -RRB- cord-287123-ldkuwcc7 234 31 . . . cord-287123-ldkuwcc7 235 1 The the DT cord-287123-ldkuwcc7 235 2 selectivity selectivity NN cord-287123-ldkuwcc7 235 3 of of IN cord-287123-ldkuwcc7 235 4 pepducins pepducin NNS cord-287123-ldkuwcc7 235 5 for for IN cord-287123-ldkuwcc7 235 6 the the DT cord-287123-ldkuwcc7 235 7 FPR2 FPR2 NNP cord-287123-ldkuwcc7 235 8 appears appear VBZ cord-287123-ldkuwcc7 235 9 not not RB cord-287123-ldkuwcc7 235 10 entirely entirely RB cord-287123-ldkuwcc7 235 11 relying rely VBG cord-287123-ldkuwcc7 235 12 on on IN cord-287123-ldkuwcc7 235 13 the the DT cord-287123-ldkuwcc7 235 14 segment segment NN cord-287123-ldkuwcc7 235 15 of of IN cord-287123-ldkuwcc7 235 16 the the DT cord-287123-ldkuwcc7 235 17 cognate cognate JJ cord-287123-ldkuwcc7 235 18 receptor receptor NN cord-287123-ldkuwcc7 235 19 . . . cord-287123-ldkuwcc7 236 1 Specific specific JJ cord-287123-ldkuwcc7 236 2 sequence sequence NN cord-287123-ldkuwcc7 236 3 and and CC cord-287123-ldkuwcc7 236 4 amino amino NN cord-287123-ldkuwcc7 236 5 acid acid NN cord-287123-ldkuwcc7 236 6 are be VBP cord-287123-ldkuwcc7 236 7 required require VBN cord-287123-ldkuwcc7 236 8 for for IN cord-287123-ldkuwcc7 236 9 the the DT cord-287123-ldkuwcc7 236 10 action action NN cord-287123-ldkuwcc7 236 11 of of IN cord-287123-ldkuwcc7 236 12 FPR2 FPR2 NNP cord-287123-ldkuwcc7 236 13 pepducins pepducin NNS cord-287123-ldkuwcc7 236 14 . . . cord-287123-ldkuwcc7 237 1 It -PRON- PRP cord-287123-ldkuwcc7 237 2 is be VBZ cord-287123-ldkuwcc7 237 3 also also RB cord-287123-ldkuwcc7 237 4 notable notable JJ cord-287123-ldkuwcc7 237 5 that that IN cord-287123-ldkuwcc7 237 6 pepducin pepducin NNS cord-287123-ldkuwcc7 237 7 derived derive VBN cord-287123-ldkuwcc7 237 8 from from IN cord-287123-ldkuwcc7 237 9 another another DT cord-287123-ldkuwcc7 237 10 intracellular intracellular JJ cord-287123-ldkuwcc7 237 11 loop loop NN cord-287123-ldkuwcc7 237 12 has have VBZ cord-287123-ldkuwcc7 237 13 no no DT cord-287123-ldkuwcc7 237 14 effect effect NN cord-287123-ldkuwcc7 237 15 [ [ -LRB- cord-287123-ldkuwcc7 237 16 168 168 CD cord-287123-ldkuwcc7 237 17 ] ] -RRB- cord-287123-ldkuwcc7 237 18 and and CC cord-287123-ldkuwcc7 237 19 pepducin pepducin NNS cord-287123-ldkuwcc7 237 20 with with IN cord-287123-ldkuwcc7 237 21 an an DT cord-287123-ldkuwcc7 237 22 amino amino NN cord-287123-ldkuwcc7 237 23 acid acid NN cord-287123-ldkuwcc7 237 24 substitution substitution NN cord-287123-ldkuwcc7 237 25 lost lose VBD cord-287123-ldkuwcc7 237 26 all all DT cord-287123-ldkuwcc7 237 27 activity activity NN cord-287123-ldkuwcc7 237 28 [ [ -LRB- cord-287123-ldkuwcc7 237 29 73 73 CD cord-287123-ldkuwcc7 237 30 ] ] -RRB- cord-287123-ldkuwcc7 237 31 . . . cord-287123-ldkuwcc7 238 1 More More JJR cord-287123-ldkuwcc7 238 2 efforts effort NNS cord-287123-ldkuwcc7 238 3 are be VBP cord-287123-ldkuwcc7 238 4 needed need VBN cord-287123-ldkuwcc7 238 5 to to TO cord-287123-ldkuwcc7 238 6 delineate delineate VB cord-287123-ldkuwcc7 238 7 the the DT cord-287123-ldkuwcc7 238 8 mechanisms mechanism NNS cord-287123-ldkuwcc7 238 9 of of IN cord-287123-ldkuwcc7 238 10 action action NN cord-287123-ldkuwcc7 238 11 by by IN cord-287123-ldkuwcc7 238 12 which which WDT cord-287123-ldkuwcc7 238 13 pepducins pepducin NNS cord-287123-ldkuwcc7 238 14 recognize recognize VBP cord-287123-ldkuwcc7 238 15 and and CC cord-287123-ldkuwcc7 238 16 modulate modulate VBP cord-287123-ldkuwcc7 238 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 238 18 . . . cord-287123-ldkuwcc7 239 1 Of of IN cord-287123-ldkuwcc7 239 2 interest interest NN cord-287123-ldkuwcc7 239 3 , , , cord-287123-ldkuwcc7 239 4 although although IN cord-287123-ldkuwcc7 239 5 FPR1 FPR1 NNP cord-287123-ldkuwcc7 239 6 and and CC cord-287123-ldkuwcc7 239 7 FPR2 FPR2 NNP cord-287123-ldkuwcc7 239 8 share share VBP cord-287123-ldkuwcc7 239 9 very very RB cord-287123-ldkuwcc7 239 10 similar similar JJ cord-287123-ldkuwcc7 239 11 sequence sequence NN cord-287123-ldkuwcc7 239 12 in in IN cord-287123-ldkuwcc7 239 13 the the DT cord-287123-ldkuwcc7 239 14 intracellular intracellular JJ cord-287123-ldkuwcc7 239 15 loops loop NNS cord-287123-ldkuwcc7 239 16 , , , cord-287123-ldkuwcc7 239 17 there there EX cord-287123-ldkuwcc7 239 18 are be VBP cord-287123-ldkuwcc7 239 19 no no DT cord-287123-ldkuwcc7 239 20 FPR1 FPR1 NNP cord-287123-ldkuwcc7 239 21 specific specific JJ cord-287123-ldkuwcc7 239 22 pepducins pepducin NNS cord-287123-ldkuwcc7 239 23 so so RB cord-287123-ldkuwcc7 239 24 far far RB cord-287123-ldkuwcc7 239 25 . . . cord-287123-ldkuwcc7 240 1 This this DT cord-287123-ldkuwcc7 240 2 suggests suggest VBZ cord-287123-ldkuwcc7 240 3 not not RB cord-287123-ldkuwcc7 240 4 only only RB cord-287123-ldkuwcc7 240 5 the the DT cord-287123-ldkuwcc7 240 6 divergence divergence NN cord-287123-ldkuwcc7 240 7 in in IN cord-287123-ldkuwcc7 240 8 the the DT cord-287123-ldkuwcc7 240 9 G g NN cord-287123-ldkuwcc7 240 10 protein protein NN cord-287123-ldkuwcc7 240 11 signaling signaling NN cord-287123-ldkuwcc7 240 12 triggered trigger VBN cord-287123-ldkuwcc7 240 13 from from IN cord-287123-ldkuwcc7 240 14 cytosolic cytosolic JJ cord-287123-ldkuwcc7 240 15 domains domain NNS cord-287123-ldkuwcc7 240 16 of of IN cord-287123-ldkuwcc7 240 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 240 18 and and CC cord-287123-ldkuwcc7 240 19 FPR2 FPR2 NNP cord-287123-ldkuwcc7 240 20 , , , cord-287123-ldkuwcc7 240 21 but but CC cord-287123-ldkuwcc7 240 22 also also RB cord-287123-ldkuwcc7 240 23 the the DT cord-287123-ldkuwcc7 240 24 presence presence NN cord-287123-ldkuwcc7 240 25 of of IN cord-287123-ldkuwcc7 240 26 different different JJ cord-287123-ldkuwcc7 240 27 forms form NNS cord-287123-ldkuwcc7 240 28 ( ( -LRB- cord-287123-ldkuwcc7 240 29 such such JJ cord-287123-ldkuwcc7 240 30 as as IN cord-287123-ldkuwcc7 240 31 homo homo NN cord-287123-ldkuwcc7 240 32 - - HYPH cord-287123-ldkuwcc7 240 33 or or CC cord-287123-ldkuwcc7 240 34 heterodimers heterodimer NNS cord-287123-ldkuwcc7 240 35 ) ) -RRB- cord-287123-ldkuwcc7 240 36 involved involve VBN cord-287123-ldkuwcc7 240 37 in in IN cord-287123-ldkuwcc7 240 38 the the DT cord-287123-ldkuwcc7 240 39 activation activation NN cord-287123-ldkuwcc7 240 40 of of IN cord-287123-ldkuwcc7 240 41 these these DT cord-287123-ldkuwcc7 240 42 two two CD cord-287123-ldkuwcc7 240 43 major major JJ cord-287123-ldkuwcc7 240 44 human human JJ cord-287123-ldkuwcc7 240 45 FPRs fpr NNS cord-287123-ldkuwcc7 240 46 . . . cord-287123-ldkuwcc7 241 1 However however RB cord-287123-ldkuwcc7 241 2 , , , cord-287123-ldkuwcc7 241 3 this this DT cord-287123-ldkuwcc7 241 4 speculation speculation NN cord-287123-ldkuwcc7 241 5 needs need VBZ cord-287123-ldkuwcc7 241 6 verification verification NN cord-287123-ldkuwcc7 241 7 . . . cord-287123-ldkuwcc7 242 1 It -PRON- PRP cord-287123-ldkuwcc7 242 2 also also RB cord-287123-ldkuwcc7 242 3 remains remain VBZ cord-287123-ldkuwcc7 242 4 a a DT cord-287123-ldkuwcc7 242 5 question question NN cord-287123-ldkuwcc7 242 6 whether whether IN cord-287123-ldkuwcc7 242 7 the the DT cord-287123-ldkuwcc7 242 8 pepducins pepducin NNS cord-287123-ldkuwcc7 242 9 mentioned mention VBN cord-287123-ldkuwcc7 242 10 above above RB cord-287123-ldkuwcc7 242 11 can can MD cord-287123-ldkuwcc7 242 12 interact interact VB cord-287123-ldkuwcc7 242 13 with with IN cord-287123-ldkuwcc7 242 14 murine murine JJ cord-287123-ldkuwcc7 242 15 Fprs Fprs NNP cord-287123-ldkuwcc7 242 16 . . . cord-287123-ldkuwcc7 243 1 As as IN cord-287123-ldkuwcc7 243 2 FPRs fpr NNS cord-287123-ldkuwcc7 243 3 are be VBP cord-287123-ldkuwcc7 243 4 potentially potentially RB cord-287123-ldkuwcc7 243 5 attractive attractive JJ cord-287123-ldkuwcc7 243 6 drug drug NN cord-287123-ldkuwcc7 243 7 target target NN cord-287123-ldkuwcc7 243 8 , , , cord-287123-ldkuwcc7 243 9 molecules molecule NNS cord-287123-ldkuwcc7 243 10 that that WDT cord-287123-ldkuwcc7 243 11 inhibit inhibit VBP cord-287123-ldkuwcc7 243 12 cell cell NN cord-287123-ldkuwcc7 243 13 responses response NNS cord-287123-ldkuwcc7 243 14 induced induce VBN cord-287123-ldkuwcc7 243 15 by by IN cord-287123-ldkuwcc7 243 16 FPR FPR NNP cord-287123-ldkuwcc7 243 17 agonists agonist NNS cord-287123-ldkuwcc7 243 18 are be VBP cord-287123-ldkuwcc7 243 19 thought think VBN cord-287123-ldkuwcc7 243 20 to to TO cord-287123-ldkuwcc7 243 21 have have VB cord-287123-ldkuwcc7 243 22 therapeutic therapeutic JJ cord-287123-ldkuwcc7 243 23 value value NN cord-287123-ldkuwcc7 243 24 for for IN cord-287123-ldkuwcc7 243 25 FPR fpr NN cord-287123-ldkuwcc7 243 26 - - HYPH cord-287123-ldkuwcc7 243 27 related relate VBN cord-287123-ldkuwcc7 243 28 diseases disease NNS cord-287123-ldkuwcc7 243 29 . . . cord-287123-ldkuwcc7 244 1 These these DT cord-287123-ldkuwcc7 244 2 molecules molecule NNS cord-287123-ldkuwcc7 244 3 , , , cord-287123-ldkuwcc7 244 4 generally generally RB cord-287123-ldkuwcc7 244 5 originating originate VBG cord-287123-ldkuwcc7 244 6 from from IN cord-287123-ldkuwcc7 244 7 natural natural JJ cord-287123-ldkuwcc7 244 8 peptides peptide NNS cord-287123-ldkuwcc7 244 9 and and CC cord-287123-ldkuwcc7 244 10 secondary secondary JJ cord-287123-ldkuwcc7 244 11 metabolites metabolite NNS cord-287123-ldkuwcc7 244 12 , , , cord-287123-ldkuwcc7 244 13 can can MD cord-287123-ldkuwcc7 244 14 interact interact VB cord-287123-ldkuwcc7 244 15 with with IN cord-287123-ldkuwcc7 244 16 FPRs fpr NNS cord-287123-ldkuwcc7 244 17 directly directly RB cord-287123-ldkuwcc7 244 18 or or CC cord-287123-ldkuwcc7 244 19 interfere interfere VB cord-287123-ldkuwcc7 244 20 with with IN cord-287123-ldkuwcc7 244 21 their -PRON- PRP$ cord-287123-ldkuwcc7 244 22 downstream downstream JJ cord-287123-ldkuwcc7 244 23 signaling signal VBG cord-287123-ldkuwcc7 244 24 pathways pathway NNS cord-287123-ldkuwcc7 244 25 . . . cord-287123-ldkuwcc7 245 1 In in IN cord-287123-ldkuwcc7 245 2 addition addition NN cord-287123-ldkuwcc7 245 3 to to IN cord-287123-ldkuwcc7 245 4 drug drug NN cord-287123-ldkuwcc7 245 5 development development NN cord-287123-ldkuwcc7 245 6 , , , cord-287123-ldkuwcc7 245 7 radio radio NN cord-287123-ldkuwcc7 245 8 - - HYPH cord-287123-ldkuwcc7 245 9 labeled label VBN cord-287123-ldkuwcc7 245 10 FPR FPR NNP cord-287123-ldkuwcc7 245 11 antagonists antagonist NNS cord-287123-ldkuwcc7 245 12 can can MD cord-287123-ldkuwcc7 245 13 be be VB cord-287123-ldkuwcc7 245 14 used use VBN cord-287123-ldkuwcc7 245 15 as as IN cord-287123-ldkuwcc7 245 16 tracking track VBG cord-287123-ldkuwcc7 245 17 probes probe NNS cord-287123-ldkuwcc7 245 18 for for IN cord-287123-ldkuwcc7 245 19 in in IN cord-287123-ldkuwcc7 245 20 vivo vivo NN cord-287123-ldkuwcc7 245 21 imaging imaging NN cord-287123-ldkuwcc7 245 22 of of IN cord-287123-ldkuwcc7 245 23 infiltrating infiltrate VBG cord-287123-ldkuwcc7 245 24 neutrophils neutrophil NNS cord-287123-ldkuwcc7 245 25 [ [ -LRB- cord-287123-ldkuwcc7 245 26 170 170 CD cord-287123-ldkuwcc7 245 27 , , , cord-287123-ldkuwcc7 245 28 171 171 CD cord-287123-ldkuwcc7 245 29 ] ] -RRB- cord-287123-ldkuwcc7 245 30 . . . cord-287123-ldkuwcc7 246 1 The the DT cord-287123-ldkuwcc7 246 2 first first JJ cord-287123-ldkuwcc7 246 3 FPR FPR NNP cord-287123-ldkuwcc7 246 4 antagonists antagonist NNS cord-287123-ldkuwcc7 246 5 were be VBD cord-287123-ldkuwcc7 246 6 obtained obtain VBN cord-287123-ldkuwcc7 246 7 by by IN cord-287123-ldkuwcc7 246 8 modifying modify VBG cord-287123-ldkuwcc7 246 9 the the DT cord-287123-ldkuwcc7 246 10 amino amino NNS cord-287123-ldkuwcc7 246 11 termini terminus NNS cord-287123-ldkuwcc7 246 12 of of IN cord-287123-ldkuwcc7 246 13 the the DT cord-287123-ldkuwcc7 246 14 classical classical JJ cord-287123-ldkuwcc7 246 15 tripeptide tripeptide NNP cord-287123-ldkuwcc7 246 16 fMLF fMLF NNP cord-287123-ldkuwcc7 246 17 . . . cord-287123-ldkuwcc7 247 1 Early early JJ cord-287123-ldkuwcc7 247 2 studies study NNS cord-287123-ldkuwcc7 247 3 have have VBP cord-287123-ldkuwcc7 247 4 shown show VBN cord-287123-ldkuwcc7 247 5 that that IN cord-287123-ldkuwcc7 247 6 the the DT cord-287123-ldkuwcc7 247 7 N N NNP cord-287123-ldkuwcc7 247 8 - - HYPH cord-287123-ldkuwcc7 247 9 formyl formyl NNP cord-287123-ldkuwcc7 247 10 group group NN cord-287123-ldkuwcc7 247 11 is be VBZ cord-287123-ldkuwcc7 247 12 important important JJ cord-287123-ldkuwcc7 247 13 for for IN cord-287123-ldkuwcc7 247 14 the the DT cord-287123-ldkuwcc7 247 15 formyl formyl NNP cord-287123-ldkuwcc7 247 16 peptides peptide NNS cord-287123-ldkuwcc7 247 17 to to TO cord-287123-ldkuwcc7 247 18 be be VB cord-287123-ldkuwcc7 247 19 recognized recognize VBN cord-287123-ldkuwcc7 247 20 by by IN cord-287123-ldkuwcc7 247 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 247 22 . . . cord-287123-ldkuwcc7 248 1 Freer free JJR cord-287123-ldkuwcc7 248 2 et et NNP cord-287123-ldkuwcc7 248 3 al al NNP cord-287123-ldkuwcc7 248 4 . . . cord-287123-ldkuwcc7 248 5 substituted substitute VBD cord-287123-ldkuwcc7 248 6 this this DT cord-287123-ldkuwcc7 248 7 group group NN cord-287123-ldkuwcc7 248 8 with with IN cord-287123-ldkuwcc7 248 9 tert tert NNP cord-287123-ldkuwcc7 248 10 - - HYPH cord-287123-ldkuwcc7 248 11 butyloxycarbonyl butyloxycarbonyl NNP cord-287123-ldkuwcc7 248 12 group group NN cord-287123-ldkuwcc7 248 13 ( ( -LRB- cord-287123-ldkuwcc7 248 14 t t NNP cord-287123-ldkuwcc7 248 15 - - HYPH cord-287123-ldkuwcc7 248 16 Boc Boc NNP cord-287123-ldkuwcc7 248 17 ) ) -RRB- cord-287123-ldkuwcc7 248 18 and and CC cord-287123-ldkuwcc7 248 19 found find VBD cord-287123-ldkuwcc7 248 20 the the DT cord-287123-ldkuwcc7 248 21 resulting result VBG cord-287123-ldkuwcc7 248 22 peptide peptide NN cord-287123-ldkuwcc7 248 23 ( ( -LRB- cord-287123-ldkuwcc7 248 24 t t NN cord-287123-ldkuwcc7 248 25 - - HYPH cord-287123-ldkuwcc7 248 26 Boc Boc NNP cord-287123-ldkuwcc7 248 27 - - HYPH cord-287123-ldkuwcc7 248 28 MLF MLF NNP cord-287123-ldkuwcc7 248 29 , , , cord-287123-ldkuwcc7 248 30 Boc-1 Boc-1 NNP cord-287123-ldkuwcc7 248 31 ) ) -RRB- cord-287123-ldkuwcc7 248 32 exhibiting exhibit VBG cord-287123-ldkuwcc7 248 33 FPR1 FPR1 NNP cord-287123-ldkuwcc7 248 34 antagonistic antagonistic JJ cord-287123-ldkuwcc7 248 35 properties property NNS cord-287123-ldkuwcc7 248 36 [ [ -LRB- cord-287123-ldkuwcc7 248 37 40 40 CD cord-287123-ldkuwcc7 248 38 ] ] -RRB- cord-287123-ldkuwcc7 248 39 . . . cord-287123-ldkuwcc7 249 1 The the DT cord-287123-ldkuwcc7 249 2 switch switch NN cord-287123-ldkuwcc7 249 3 from from IN cord-287123-ldkuwcc7 249 4 an an DT cord-287123-ldkuwcc7 249 5 agonist agonist NN cord-287123-ldkuwcc7 249 6 to to IN cord-287123-ldkuwcc7 249 7 an an DT cord-287123-ldkuwcc7 249 8 antagonist antagonist NN cord-287123-ldkuwcc7 249 9 was be VBD cord-287123-ldkuwcc7 249 10 also also RB cord-287123-ldkuwcc7 249 11 observed observe VBN cord-287123-ldkuwcc7 249 12 when when WRB cord-287123-ldkuwcc7 249 13 other other JJ cord-287123-ldkuwcc7 249 14 carbamates carbamate NNS cord-287123-ldkuwcc7 249 15 ( ( -LRB- cord-287123-ldkuwcc7 249 16 such such JJ cord-287123-ldkuwcc7 249 17 as as IN cord-287123-ldkuwcc7 249 18 iso iso NN cord-287123-ldkuwcc7 249 19 - - HYPH cord-287123-ldkuwcc7 249 20 butyloxycarbonyl butyloxycarbonyl NN cord-287123-ldkuwcc7 249 21 and and CC cord-287123-ldkuwcc7 249 22 benzyloxycarbonyl benzyloxycarbonyl NNP cord-287123-ldkuwcc7 249 23 group group NN cord-287123-ldkuwcc7 249 24 ) ) -RRB- cord-287123-ldkuwcc7 249 25 were be VBD cord-287123-ldkuwcc7 249 26 used use VBN cord-287123-ldkuwcc7 249 27 to to TO cord-287123-ldkuwcc7 249 28 replace replace VB cord-287123-ldkuwcc7 249 29 the the DT cord-287123-ldkuwcc7 249 30 formyl formyl NNP cord-287123-ldkuwcc7 249 31 group group NN cord-287123-ldkuwcc7 249 32 at at IN cord-287123-ldkuwcc7 249 33 the the DT cord-287123-ldkuwcc7 249 34 amino amino NN cord-287123-ldkuwcc7 249 35 terminus terminus NN cord-287123-ldkuwcc7 249 36 [ [ -LRB- cord-287123-ldkuwcc7 249 37 172 172 CD cord-287123-ldkuwcc7 249 38 ] ] -RRB- cord-287123-ldkuwcc7 249 39 . . . cord-287123-ldkuwcc7 250 1 Further further RB cord-287123-ldkuwcc7 250 2 C c NN cord-287123-ldkuwcc7 250 3 - - HYPH cord-287123-ldkuwcc7 250 4 terminal terminal NN cord-287123-ldkuwcc7 250 5 modification modification NN cord-287123-ldkuwcc7 250 6 of of IN cord-287123-ldkuwcc7 250 7 iso iso NN cord-287123-ldkuwcc7 250 8 - - HYPH cord-287123-ldkuwcc7 250 9 butyloxycarbonyl butyloxycarbonyl NN cord-287123-ldkuwcc7 250 10 - - HYPH cord-287123-ldkuwcc7 250 11 MLF mlf NN cord-287123-ldkuwcc7 250 12 ( ( -LRB- cord-287123-ldkuwcc7 250 13 i i NNP cord-287123-ldkuwcc7 250 14 - - HYPH cord-287123-ldkuwcc7 250 15 Boc Boc NNP cord-287123-ldkuwcc7 250 16 - - HYPH cord-287123-ldkuwcc7 250 17 MLF MLF NNP cord-287123-ldkuwcc7 250 18 ) ) -RRB- cord-287123-ldkuwcc7 250 19 did do VBD cord-287123-ldkuwcc7 250 20 not not RB cord-287123-ldkuwcc7 250 21 alter alter VB cord-287123-ldkuwcc7 250 22 the the DT cord-287123-ldkuwcc7 250 23 antagonistic antagonistic JJ cord-287123-ldkuwcc7 250 24 potency potency NN cord-287123-ldkuwcc7 250 25 , , , cord-287123-ldkuwcc7 250 26 implying imply VBG cord-287123-ldkuwcc7 250 27 the the DT cord-287123-ldkuwcc7 250 28 different different JJ cord-287123-ldkuwcc7 250 29 roles role NNS cord-287123-ldkuwcc7 250 30 of of IN cord-287123-ldkuwcc7 250 31 amino amino NNS cord-287123-ldkuwcc7 250 32 and and CC cord-287123-ldkuwcc7 250 33 carboxyl carboxyl NN cord-287123-ldkuwcc7 250 34 terminus terminus NN cord-287123-ldkuwcc7 250 35 in in IN cord-287123-ldkuwcc7 250 36 conferring confer VBG cord-287123-ldkuwcc7 250 37 the the DT cord-287123-ldkuwcc7 250 38 activities activity NNS cord-287123-ldkuwcc7 250 39 to to IN cord-287123-ldkuwcc7 250 40 these these DT cord-287123-ldkuwcc7 250 41 peptides peptide NNS cord-287123-ldkuwcc7 250 42 . . . cord-287123-ldkuwcc7 251 1 The the DT cord-287123-ldkuwcc7 251 2 t t NN cord-287123-ldkuwcc7 251 3 - - HYPH cord-287123-ldkuwcc7 251 4 butyloxycarbonyl butyloxycarbonyl NNP cord-287123-ldkuwcc7 251 5 analog analog NN cord-287123-ldkuwcc7 251 6 of of IN cord-287123-ldkuwcc7 251 7 formylated formylated JJ cord-287123-ldkuwcc7 251 8 peptide peptide NNP cord-287123-ldkuwcc7 251 9 f f NNP cord-287123-ldkuwcc7 251 10 - - HYPH cord-287123-ldkuwcc7 251 11 FLFLF FLFLF NNP cord-287123-ldkuwcc7 251 12 ( ( -LRB- cord-287123-ldkuwcc7 251 13 t t NNP cord-287123-ldkuwcc7 251 14 - - HYPH cord-287123-ldkuwcc7 251 15 Boc Boc NNP cord-287123-ldkuwcc7 251 16 - - HYPH cord-287123-ldkuwcc7 251 17 FLFLF FLFLF NNP cord-287123-ldkuwcc7 251 18 , , , cord-287123-ldkuwcc7 251 19 Boc-2 Boc-2 NNP cord-287123-ldkuwcc7 251 20 ) ) -RRB- cord-287123-ldkuwcc7 251 21 is be VBZ cord-287123-ldkuwcc7 251 22 another another DT cord-287123-ldkuwcc7 251 23 antagonistic antagonistic JJ cord-287123-ldkuwcc7 251 24 peptide peptide NN cord-287123-ldkuwcc7 251 25 that that WDT cord-287123-ldkuwcc7 251 26 potently potently RB cord-287123-ldkuwcc7 251 27 inhibits inhibit VBZ cord-287123-ldkuwcc7 251 28 neutrophil neutrophil NN cord-287123-ldkuwcc7 251 29 NADPH nadph NN cord-287123-ldkuwcc7 251 30 - - HYPH cord-287123-ldkuwcc7 251 31 oxidase oxidase NN cord-287123-ldkuwcc7 251 32 activity activity NN cord-287123-ldkuwcc7 251 33 induced induce VBN cord-287123-ldkuwcc7 251 34 by by IN cord-287123-ldkuwcc7 251 35 fMLF fMLF NNP cord-287123-ldkuwcc7 251 36 [ [ -LRB- cord-287123-ldkuwcc7 251 37 40 40 CD cord-287123-ldkuwcc7 251 38 , , , cord-287123-ldkuwcc7 251 39 173 173 CD cord-287123-ldkuwcc7 251 40 , , , cord-287123-ldkuwcc7 251 41 174 174 CD cord-287123-ldkuwcc7 251 42 ] ] -RRB- cord-287123-ldkuwcc7 251 43 . . . cord-287123-ldkuwcc7 252 1 There there EX cord-287123-ldkuwcc7 252 2 is be VBZ cord-287123-ldkuwcc7 252 3 evidence evidence NN cord-287123-ldkuwcc7 252 4 that that IN cord-287123-ldkuwcc7 252 5 Boc-1 Boc-1 NNP cord-287123-ldkuwcc7 252 6 and and CC cord-287123-ldkuwcc7 252 7 Boc-2 Boc-2 NNP cord-287123-ldkuwcc7 252 8 begin begin VBP cord-287123-ldkuwcc7 252 9 to to TO cord-287123-ldkuwcc7 252 10 lose lose VB cord-287123-ldkuwcc7 252 11 their -PRON- PRP$ cord-287123-ldkuwcc7 252 12 receptor receptor NN cord-287123-ldkuwcc7 252 13 preference preference NN cord-287123-ldkuwcc7 252 14 to to IN cord-287123-ldkuwcc7 252 15 FPR1 FPR1 NNP cord-287123-ldkuwcc7 252 16 at at IN cord-287123-ldkuwcc7 252 17 high high JJ cord-287123-ldkuwcc7 252 18 concentrations concentration NNS cord-287123-ldkuwcc7 252 19 ( ( -LRB- cord-287123-ldkuwcc7 252 20 > > NFP cord-287123-ldkuwcc7 252 21 5 5 CD cord-287123-ldkuwcc7 252 22 µM µM NNP cord-287123-ldkuwcc7 252 23 ) ) -RRB- cord-287123-ldkuwcc7 252 24 and and CC cord-287123-ldkuwcc7 252 25 display display VB cord-287123-ldkuwcc7 252 26 inhibitory inhibitory JJ cord-287123-ldkuwcc7 252 27 effects effect NNS cord-287123-ldkuwcc7 252 28 on on IN cord-287123-ldkuwcc7 252 29 FPR2 FPR2 NNP cord-287123-ldkuwcc7 252 30 and and CC cord-287123-ldkuwcc7 252 31 even even RB cord-287123-ldkuwcc7 252 32 the the DT cord-287123-ldkuwcc7 252 33 complement complement JJ cord-287123-ldkuwcc7 252 34 component component NN cord-287123-ldkuwcc7 252 35 5a 5a CD cord-287123-ldkuwcc7 253 1 ( ( -LRB- cord-287123-ldkuwcc7 253 2 C5a)-induced c5a)-induced CD cord-287123-ldkuwcc7 253 3 responses response NNS cord-287123-ldkuwcc7 253 4 [ [ -LRB- cord-287123-ldkuwcc7 253 5 174 174 CD cord-287123-ldkuwcc7 253 6 ] ] -RRB- cord-287123-ldkuwcc7 253 7 . . . cord-287123-ldkuwcc7 254 1 Thus thus RB cord-287123-ldkuwcc7 254 2 , , , cord-287123-ldkuwcc7 254 3 despite despite IN cord-287123-ldkuwcc7 254 4 their -PRON- PRP$ cord-287123-ldkuwcc7 254 5 fairly fairly RB cord-287123-ldkuwcc7 254 6 specific specific JJ cord-287123-ldkuwcc7 254 7 activity activity NN cord-287123-ldkuwcc7 254 8 at at IN cord-287123-ldkuwcc7 254 9 low low JJ cord-287123-ldkuwcc7 254 10 concentrations concentration NNS cord-287123-ldkuwcc7 254 11 , , , cord-287123-ldkuwcc7 254 12 these these DT cord-287123-ldkuwcc7 254 13 Boc Boc NNP cord-287123-ldkuwcc7 254 14 peptides peptide NNS cord-287123-ldkuwcc7 254 15 may may MD cord-287123-ldkuwcc7 254 16 be be VB cord-287123-ldkuwcc7 254 17 classified classify VBN cord-287123-ldkuwcc7 254 18 as as IN cord-287123-ldkuwcc7 254 19 pan pan NN cord-287123-ldkuwcc7 254 20 - - NNS cord-287123-ldkuwcc7 254 21 antagonists antagonist NNS cord-287123-ldkuwcc7 254 22 for for IN cord-287123-ldkuwcc7 254 23 FPRs fpr NNS cord-287123-ldkuwcc7 254 24 . . . cord-287123-ldkuwcc7 255 1 However however RB cord-287123-ldkuwcc7 255 2 , , , cord-287123-ldkuwcc7 255 3 other other JJ cord-287123-ldkuwcc7 255 4 disagree disagree VBP cord-287123-ldkuwcc7 255 5 because because IN cord-287123-ldkuwcc7 255 6 receptor receptor NN cord-287123-ldkuwcc7 255 7 overlap overlap NN cord-287123-ldkuwcc7 255 8 was be VBD cord-287123-ldkuwcc7 255 9 seen see VBN cord-287123-ldkuwcc7 255 10 at at IN cord-287123-ldkuwcc7 255 11 high high JJ cord-287123-ldkuwcc7 255 12 concentrations concentration NNS cord-287123-ldkuwcc7 255 13 of of IN cord-287123-ldkuwcc7 255 14 all all DT cord-287123-ldkuwcc7 255 15 antagonists antagonist NNS cord-287123-ldkuwcc7 255 16 [ [ -LRB- cord-287123-ldkuwcc7 255 17 5 5 CD cord-287123-ldkuwcc7 255 18 ] ] -RRB- cord-287123-ldkuwcc7 255 19 . . . cord-287123-ldkuwcc7 256 1 In in IN cord-287123-ldkuwcc7 256 2 a a DT cord-287123-ldkuwcc7 256 3 recent recent JJ cord-287123-ldkuwcc7 256 4 study study NN cord-287123-ldkuwcc7 256 5 , , , cord-287123-ldkuwcc7 256 6 optimization optimization NN cord-287123-ldkuwcc7 256 7 at at IN cord-287123-ldkuwcc7 256 8 the the DT cord-287123-ldkuwcc7 256 9 Phe Phe NNP cord-287123-ldkuwcc7 256 10 residues residue NNS cord-287123-ldkuwcc7 256 11 of of IN cord-287123-ldkuwcc7 257 1 Boc-2 Boc-2 NNP cord-287123-ldkuwcc7 257 2 following follow VBG cord-287123-ldkuwcc7 257 3 Ala Ala NNP cord-287123-ldkuwcc7 257 4 - - HYPH cord-287123-ldkuwcc7 257 5 scanning scanning NN cord-287123-ldkuwcc7 257 6 led lead VBD cord-287123-ldkuwcc7 257 7 to to IN cord-287123-ldkuwcc7 257 8 a a DT cord-287123-ldkuwcc7 257 9 more more RBR cord-287123-ldkuwcc7 257 10 potent potent JJ cord-287123-ldkuwcc7 257 11 FPR1-selective fpr1-selective JJ cord-287123-ldkuwcc7 257 12 antagonist antagonist NN cord-287123-ldkuwcc7 257 13 [ [ -LRB- cord-287123-ldkuwcc7 257 14 175 175 CD cord-287123-ldkuwcc7 257 15 ] ] -RRB- cord-287123-ldkuwcc7 257 16 . . . cord-287123-ldkuwcc7 258 1 Nevertheless nevertheless RB cord-287123-ldkuwcc7 258 2 , , , cord-287123-ldkuwcc7 258 3 among among IN cord-287123-ldkuwcc7 258 4 the the DT cord-287123-ldkuwcc7 258 5 available available JJ cord-287123-ldkuwcc7 258 6 formyl formyl NNP cord-287123-ldkuwcc7 258 7 peptide peptide NN cord-287123-ldkuwcc7 258 8 - - HYPH cord-287123-ldkuwcc7 258 9 derived derive VBN cord-287123-ldkuwcc7 258 10 antagonists antagonist NNS cord-287123-ldkuwcc7 258 11 , , , cord-287123-ldkuwcc7 258 12 Boc-1 Boc-1 NNP cord-287123-ldkuwcc7 258 13 and and CC cord-287123-ldkuwcc7 258 14 Boc-2 Boc-2 NNP cord-287123-ldkuwcc7 258 15 are be VBP cord-287123-ldkuwcc7 258 16 still still RB cord-287123-ldkuwcc7 258 17 most most RBS cord-287123-ldkuwcc7 258 18 potent potent JJ cord-287123-ldkuwcc7 258 19 and and CC cord-287123-ldkuwcc7 258 20 commonly commonly RB cord-287123-ldkuwcc7 258 21 used use VBN cord-287123-ldkuwcc7 258 22 in in IN cord-287123-ldkuwcc7 258 23 experiments experiment NNS cord-287123-ldkuwcc7 258 24 . . . cord-287123-ldkuwcc7 259 1 Chemotaxis Chemotaxis NNP cord-287123-ldkuwcc7 259 2 inhibitory inhibitory JJ cord-287123-ldkuwcc7 259 3 protein protein NN cord-287123-ldkuwcc7 259 4 of of IN cord-287123-ldkuwcc7 259 5 S. S. NNP cord-287123-ldkuwcc7 259 6 aureus aureus NN cord-287123-ldkuwcc7 259 7 ( ( -LRB- cord-287123-ldkuwcc7 259 8 CHIPS chip NNS cord-287123-ldkuwcc7 259 9 ) ) -RRB- cord-287123-ldkuwcc7 259 10 is be VBZ cord-287123-ldkuwcc7 259 11 another another DT cord-287123-ldkuwcc7 259 12 native native JJ cord-287123-ldkuwcc7 259 13 protein protein NN cord-287123-ldkuwcc7 259 14 ( ( -LRB- cord-287123-ldkuwcc7 259 15 14.1 14.1 CD cord-287123-ldkuwcc7 259 16 kDa kDa NNPS cord-287123-ldkuwcc7 259 17 ) ) -RRB- cord-287123-ldkuwcc7 259 18 with with IN cord-287123-ldkuwcc7 259 19 FPR fpr NN cord-287123-ldkuwcc7 259 20 antagonistic antagonistic JJ cord-287123-ldkuwcc7 259 21 activity activity NN cord-287123-ldkuwcc7 259 22 . . . cord-287123-ldkuwcc7 260 1 The the DT cord-287123-ldkuwcc7 260 2 full full JJ cord-287123-ldkuwcc7 260 3 length length NN cord-287123-ldkuwcc7 260 4 CHIPS chip NNS cord-287123-ldkuwcc7 260 5 ( ( -LRB- cord-287123-ldkuwcc7 260 6 121 121 CD cord-287123-ldkuwcc7 260 7 amino amino JJ cord-287123-ldkuwcc7 260 8 acids acid NNS cord-287123-ldkuwcc7 260 9 ) ) -RRB- cord-287123-ldkuwcc7 260 10 was be VBD cord-287123-ldkuwcc7 260 11 first first RB cord-287123-ldkuwcc7 260 12 reported report VBN cord-287123-ldkuwcc7 260 13 to to TO cord-287123-ldkuwcc7 260 14 be be VB cord-287123-ldkuwcc7 260 15 an an DT cord-287123-ldkuwcc7 260 16 antagonist antagonist NN cord-287123-ldkuwcc7 260 17 for for IN cord-287123-ldkuwcc7 260 18 both both CC cord-287123-ldkuwcc7 260 19 FPR1 FPR1 NNP cord-287123-ldkuwcc7 260 20 and and CC cord-287123-ldkuwcc7 260 21 the the DT cord-287123-ldkuwcc7 260 22 C5a C5a NNS cord-287123-ldkuwcc7 260 23 receptor receptor NN cord-287123-ldkuwcc7 260 24 [ [ -LRB- cord-287123-ldkuwcc7 260 25 176 176 CD cord-287123-ldkuwcc7 260 26 ] ] -RRB- cord-287123-ldkuwcc7 260 27 . . . cord-287123-ldkuwcc7 261 1 However however RB cord-287123-ldkuwcc7 261 2 , , , cord-287123-ldkuwcc7 261 3 the the DT cord-287123-ldkuwcc7 261 4 N n CD cord-287123-ldkuwcc7 261 5 - - HYPH cord-287123-ldkuwcc7 261 6 terminal terminal NN cord-287123-ldkuwcc7 261 7 peptides peptide NNS cord-287123-ldkuwcc7 261 8 FTFEPFPTNEEIESN FTFEPFPTNEEIESN NNP cord-287123-ldkuwcc7 261 9 and and CC cord-287123-ldkuwcc7 261 10 FTFEPF FTFEPF NNP cord-287123-ldkuwcc7 261 11 ( ( -LRB- cord-287123-ldkuwcc7 261 12 the the DT cord-287123-ldkuwcc7 261 13 first first JJ cord-287123-ldkuwcc7 261 14 six six CD cord-287123-ldkuwcc7 261 15 residues residue NNS cord-287123-ldkuwcc7 261 16 ) ) -RRB- cord-287123-ldkuwcc7 261 17 display display VBP cord-287123-ldkuwcc7 261 18 only only RB cord-287123-ldkuwcc7 261 19 anti anti JJ cord-287123-ldkuwcc7 261 20 - - JJ cord-287123-ldkuwcc7 261 21 FPR1 fpr1 JJ cord-287123-ldkuwcc7 261 22 properties property NNS cord-287123-ldkuwcc7 261 23 [ [ -LRB- cord-287123-ldkuwcc7 261 24 85 85 CD cord-287123-ldkuwcc7 261 25 ] ] -RRB- cord-287123-ldkuwcc7 261 26 , , , cord-287123-ldkuwcc7 261 27 suggesting suggest VBG cord-287123-ldkuwcc7 261 28 a a DT cord-287123-ldkuwcc7 261 29 mechanism mechanism NN cord-287123-ldkuwcc7 261 30 of of IN cord-287123-ldkuwcc7 261 31 S. S. NNP cord-287123-ldkuwcc7 261 32 aureus aureus NN cord-287123-ldkuwcc7 261 33 invasion invasion NN cord-287123-ldkuwcc7 261 34 through through IN cord-287123-ldkuwcc7 261 35 inhibiting inhibit VBG cord-287123-ldkuwcc7 261 36 fMLF fmlf JJ cord-287123-ldkuwcc7 261 37 - - HYPH cord-287123-ldkuwcc7 261 38 induced induce VBN cord-287123-ldkuwcc7 261 39 neutrophil neutrophil NN cord-287123-ldkuwcc7 261 40 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 261 41 . . . cord-287123-ldkuwcc7 262 1 Accordingly accordingly RB cord-287123-ldkuwcc7 262 2 , , , cord-287123-ldkuwcc7 262 3 neutralizing neutralize VBG cord-287123-ldkuwcc7 262 4 antibodies antibody NNS cord-287123-ldkuwcc7 262 5 against against IN cord-287123-ldkuwcc7 262 6 CHIPS chip NNS cord-287123-ldkuwcc7 262 7 may may MD cord-287123-ldkuwcc7 262 8 be be VB cord-287123-ldkuwcc7 262 9 useful useful JJ cord-287123-ldkuwcc7 262 10 for for IN cord-287123-ldkuwcc7 262 11 treating treat VBG cord-287123-ldkuwcc7 262 12 S. S. NNP cord-287123-ldkuwcc7 262 13 aureus aureus NN cord-287123-ldkuwcc7 262 14 infection infection NN cord-287123-ldkuwcc7 262 15 [ [ -LRB- cord-287123-ldkuwcc7 262 16 177 177 CD cord-287123-ldkuwcc7 262 17 ] ] -RRB- cord-287123-ldkuwcc7 262 18 given give VBN cord-287123-ldkuwcc7 262 19 the the DT cord-287123-ldkuwcc7 262 20 fact fact NN cord-287123-ldkuwcc7 262 21 that that IN cord-287123-ldkuwcc7 262 22 CHIPS chip NNS cord-287123-ldkuwcc7 262 23 can can MD cord-287123-ldkuwcc7 262 24 bind bind VB cord-287123-ldkuwcc7 262 25 to to IN cord-287123-ldkuwcc7 262 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 262 27 with with IN cord-287123-ldkuwcc7 262 28 high high JJ cord-287123-ldkuwcc7 262 29 affinity affinity NN cord-287123-ldkuwcc7 262 30 ( ( -LRB- cord-287123-ldkuwcc7 262 31 K K NNP cord-287123-ldkuwcc7 262 32 d~3 d~3 NNP cord-287123-ldkuwcc7 262 33 5 5 CD cord-287123-ldkuwcc7 262 34 nM nm CD cord-287123-ldkuwcc7 262 35 ) ) -RRB- cord-287123-ldkuwcc7 262 36 [ [ -LRB- cord-287123-ldkuwcc7 262 37 176 176 CD cord-287123-ldkuwcc7 262 38 ] ] -RRB- cord-287123-ldkuwcc7 262 39 . . . cord-287123-ldkuwcc7 263 1 In in IN cord-287123-ldkuwcc7 263 2 addition addition NN cord-287123-ldkuwcc7 263 3 , , , cord-287123-ldkuwcc7 263 4 another another DT cord-287123-ldkuwcc7 263 5 S. S. NNP cord-287123-ldkuwcc7 263 6 aureus aureus NN cord-287123-ldkuwcc7 263 7 - - HYPH cord-287123-ldkuwcc7 263 8 derived derive VBN cord-287123-ldkuwcc7 263 9 105-amino 105-amino CD cord-287123-ldkuwcc7 263 10 acid acid NN cord-287123-ldkuwcc7 263 11 protein protein NN cord-287123-ldkuwcc7 263 12 FLIPr FLIPr NNS cord-287123-ldkuwcc7 263 13 ( ( -LRB- cord-287123-ldkuwcc7 263 14 FPR fpr NN cord-287123-ldkuwcc7 263 15 - - HYPH cord-287123-ldkuwcc7 263 16 like like JJ cord-287123-ldkuwcc7 263 17 1 1 CD cord-287123-ldkuwcc7 263 18 inhibitory inhibitory JJ cord-287123-ldkuwcc7 263 19 protein protein NN cord-287123-ldkuwcc7 263 20 ) ) -RRB- cord-287123-ldkuwcc7 263 21 , , , cord-287123-ldkuwcc7 263 22 was be VBD cord-287123-ldkuwcc7 263 23 reported report VBN cord-287123-ldkuwcc7 263 24 to to TO cord-287123-ldkuwcc7 263 25 selectively selectively RB cord-287123-ldkuwcc7 263 26 inhibit inhibit VB cord-287123-ldkuwcc7 263 27 the the DT cord-287123-ldkuwcc7 263 28 binding binding NN cord-287123-ldkuwcc7 263 29 of of IN cord-287123-ldkuwcc7 263 30 and and CC cord-287123-ldkuwcc7 263 31 activation activation NN cord-287123-ldkuwcc7 263 32 by by IN cord-287123-ldkuwcc7 263 33 FPR2 FPR2 NNP cord-287123-ldkuwcc7 263 34 agonists agonist NNS cord-287123-ldkuwcc7 263 35 [ [ -LRB- cord-287123-ldkuwcc7 263 36 178 178 CD cord-287123-ldkuwcc7 263 37 ] ] -RRB- cord-287123-ldkuwcc7 263 38 . . . cord-287123-ldkuwcc7 264 1 Several several JJ cord-287123-ldkuwcc7 264 2 peptides peptide NNS cord-287123-ldkuwcc7 264 3 derived derive VBN cord-287123-ldkuwcc7 264 4 from from IN cord-287123-ldkuwcc7 264 5 viruses virus NNS cord-287123-ldkuwcc7 264 6 were be VBD cord-287123-ldkuwcc7 264 7 also also RB cord-287123-ldkuwcc7 264 8 found find VBN cord-287123-ldkuwcc7 264 9 inhibitory inhibitory JJ cord-287123-ldkuwcc7 264 10 to to IN cord-287123-ldkuwcc7 264 11 FPR FPR NNP cord-287123-ldkuwcc7 264 12 activation activation NN cord-287123-ldkuwcc7 264 13 . . . cord-287123-ldkuwcc7 265 1 These these DT cord-287123-ldkuwcc7 265 2 peptides peptide NNS cord-287123-ldkuwcc7 265 3 include include VBP cord-287123-ldkuwcc7 265 4 a a DT cord-287123-ldkuwcc7 265 5 retroviral retroviral JJ cord-287123-ldkuwcc7 265 6 p15E p15e JJ cord-287123-ldkuwcc7 265 7 - - HYPH cord-287123-ldkuwcc7 265 8 derived derive VBN cord-287123-ldkuwcc7 265 9 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 265 10 ( ( -LRB- cord-287123-ldkuwcc7 265 11 LDLLFL LDLLFL NNP cord-287123-ldkuwcc7 265 12 ) ) -RRB- cord-287123-ldkuwcc7 265 13 that that WDT cord-287123-ldkuwcc7 265 14 can can MD cord-287123-ldkuwcc7 265 15 inhibit inhibit VB cord-287123-ldkuwcc7 265 16 fMLF fmlf JJ cord-287123-ldkuwcc7 265 17 - - HYPH cord-287123-ldkuwcc7 265 18 induced induce VBN cord-287123-ldkuwcc7 265 19 response response NN cord-287123-ldkuwcc7 265 20 in in IN cord-287123-ldkuwcc7 265 21 monocytes monocyte NNS cord-287123-ldkuwcc7 265 22 and and CC cord-287123-ldkuwcc7 265 23 granulocytes granulocyte NNS cord-287123-ldkuwcc7 265 24 [ [ -LRB- cord-287123-ldkuwcc7 265 25 179 179 CD cord-287123-ldkuwcc7 265 26 ] ] -RRB- cord-287123-ldkuwcc7 265 27 , , , cord-287123-ldkuwcc7 265 28 and and CC cord-287123-ldkuwcc7 265 29 a a DT cord-287123-ldkuwcc7 265 30 coronavirus coronavirus NN cord-287123-ldkuwcc7 265 31 229E 229e CD cord-287123-ldkuwcc7 265 32 - - : cord-287123-ldkuwcc7 265 33 derived derive VBN cord-287123-ldkuwcc7 265 34 12-mer 12-mer CD cord-287123-ldkuwcc7 265 35 peptide peptide NN cord-287123-ldkuwcc7 265 36 ( ( -LRB- cord-287123-ldkuwcc7 265 37 ETYIKPWWVWL ETYIKPWWVWL NNP cord-287123-ldkuwcc7 265 38 ) ) -RRB- cord-287123-ldkuwcc7 265 39 that that WDT cord-287123-ldkuwcc7 265 40 was be VBD cord-287123-ldkuwcc7 265 41 identified identify VBN cord-287123-ldkuwcc7 265 42 as as IN cord-287123-ldkuwcc7 265 43 a a DT cord-287123-ldkuwcc7 265 44 potent potent JJ cord-287123-ldkuwcc7 265 45 antagonist antagonist NN cord-287123-ldkuwcc7 265 46 of of IN cord-287123-ldkuwcc7 265 47 FPR1 FPR1 NNP cord-287123-ldkuwcc7 265 48 with with IN cord-287123-ldkuwcc7 265 49 a a DT cord-287123-ldkuwcc7 265 50 K k NN cord-287123-ldkuwcc7 265 51 i i PRP cord-287123-ldkuwcc7 265 52 of of IN cord-287123-ldkuwcc7 265 53 230 230 CD cord-287123-ldkuwcc7 265 54 nM nm CD cord-287123-ldkuwcc7 265 55 [ [ -LRB- cord-287123-ldkuwcc7 265 56 180 180 CD cord-287123-ldkuwcc7 265 57 ] ] -RRB- cord-287123-ldkuwcc7 265 58 . . . cord-287123-ldkuwcc7 266 1 Additional additional JJ cord-287123-ldkuwcc7 266 2 peptides peptide NNS cord-287123-ldkuwcc7 266 3 isolated isolate VBN cord-287123-ldkuwcc7 266 4 from from IN cord-287123-ldkuwcc7 266 5 HIV-1 HIV-1 NNP cord-287123-ldkuwcc7 266 6 , , , cord-287123-ldkuwcc7 266 7 HIV-2 HIV-2 NNP cord-287123-ldkuwcc7 266 8 , , , cord-287123-ldkuwcc7 266 9 severe severe JJ cord-287123-ldkuwcc7 266 10 acute acute JJ cord-287123-ldkuwcc7 266 11 respiratory respiratory JJ cord-287123-ldkuwcc7 266 12 syndrome syndrome NN cord-287123-ldkuwcc7 266 13 coronavirus coronavirus NN cord-287123-ldkuwcc7 266 14 and and CC cord-287123-ldkuwcc7 266 15 Ebola Ebola NNP cord-287123-ldkuwcc7 266 16 virus virus NN cord-287123-ldkuwcc7 266 17 were be VBD cord-287123-ldkuwcc7 266 18 reported report VBN cord-287123-ldkuwcc7 266 19 as as IN cord-287123-ldkuwcc7 266 20 FPR1 FPR1 NNP cord-287123-ldkuwcc7 266 21 antagonists antagonist NNS cord-287123-ldkuwcc7 266 22 with with IN cord-287123-ldkuwcc7 266 23 lower low JJR cord-287123-ldkuwcc7 266 24 affinities affinity NNS cord-287123-ldkuwcc7 266 25 [ [ -LRB- cord-287123-ldkuwcc7 266 26 180 180 CD cord-287123-ldkuwcc7 266 27 ] ] -RRB- cord-287123-ldkuwcc7 266 28 . . . cord-287123-ldkuwcc7 267 1 It -PRON- PRP cord-287123-ldkuwcc7 267 2 is be VBZ cord-287123-ldkuwcc7 267 3 interesting interesting JJ cord-287123-ldkuwcc7 267 4 that that IN cord-287123-ldkuwcc7 267 5 N n NN cord-287123-ldkuwcc7 267 6 - - HYPH cord-287123-ldkuwcc7 267 7 formylation formylation NN cord-287123-ldkuwcc7 267 8 of of IN cord-287123-ldkuwcc7 267 9 ETYIKPWWVWL ETYIKPWWVWL NNP cord-287123-ldkuwcc7 267 10 transforms transform VBZ cord-287123-ldkuwcc7 267 11 this this DT cord-287123-ldkuwcc7 267 12 12-mer 12-mer CD cord-287123-ldkuwcc7 267 13 peptide peptide NN cord-287123-ldkuwcc7 267 14 into into IN cord-287123-ldkuwcc7 267 15 an an DT cord-287123-ldkuwcc7 267 16 FPR1 FPR1 NNP cord-287123-ldkuwcc7 267 17 agonist agonist NN cord-287123-ldkuwcc7 267 18 , , , cord-287123-ldkuwcc7 267 19 which which WDT cord-287123-ldkuwcc7 267 20 is be VBZ cord-287123-ldkuwcc7 267 21 consistent consistent JJ cord-287123-ldkuwcc7 267 22 with with IN cord-287123-ldkuwcc7 267 23 the the DT cord-287123-ldkuwcc7 267 24 notion notion NN cord-287123-ldkuwcc7 267 25 that that IN cord-287123-ldkuwcc7 267 26 modification modification NN cord-287123-ldkuwcc7 267 27 of of IN cord-287123-ldkuwcc7 267 28 size size NN cord-287123-ldkuwcc7 267 29 and and CC cord-287123-ldkuwcc7 267 30 shape shape NN cord-287123-ldkuwcc7 267 31 at at IN cord-287123-ldkuwcc7 267 32 the the DT cord-287123-ldkuwcc7 267 33 amino amino NN cord-287123-ldkuwcc7 267 34 terminus terminus NN cord-287123-ldkuwcc7 267 35 can can MD cord-287123-ldkuwcc7 267 36 change change VB cord-287123-ldkuwcc7 267 37 the the DT cord-287123-ldkuwcc7 267 38 FPR FPR NNP cord-287123-ldkuwcc7 267 39 agonistic agonistic JJ cord-287123-ldkuwcc7 267 40 / / SYM cord-287123-ldkuwcc7 267 41 antagonistic antagonistic JJ cord-287123-ldkuwcc7 267 42 property property NN cord-287123-ldkuwcc7 267 43 of of IN cord-287123-ldkuwcc7 267 44 some some DT cord-287123-ldkuwcc7 267 45 peptides peptide NNS cord-287123-ldkuwcc7 267 46 . . . cord-287123-ldkuwcc7 268 1 Among among IN cord-287123-ldkuwcc7 268 2 the the DT cord-287123-ldkuwcc7 268 3 antagonistic antagonistic JJ cord-287123-ldkuwcc7 268 4 cyclic cyclic JJ cord-287123-ldkuwcc7 268 5 peptides peptide NNS cord-287123-ldkuwcc7 268 6 from from IN cord-287123-ldkuwcc7 268 7 natural natural JJ cord-287123-ldkuwcc7 268 8 sources source NNS cord-287123-ldkuwcc7 268 9 , , , cord-287123-ldkuwcc7 268 10 cyclosporin cyclosporin NN cord-287123-ldkuwcc7 268 11 H h NN cord-287123-ldkuwcc7 268 12 ( ( -LRB- cord-287123-ldkuwcc7 268 13 CsH CsH NNP cord-287123-ldkuwcc7 268 14 ) ) -RRB- cord-287123-ldkuwcc7 268 15 is be VBZ cord-287123-ldkuwcc7 268 16 one one CD cord-287123-ldkuwcc7 268 17 of of IN cord-287123-ldkuwcc7 268 18 the the DT cord-287123-ldkuwcc7 268 19 most most RBS cord-287123-ldkuwcc7 268 20 potent potent JJ cord-287123-ldkuwcc7 268 21 and and CC cord-287123-ldkuwcc7 268 22 specific specific JJ cord-287123-ldkuwcc7 268 23 FPR1 FPR1 NNP cord-287123-ldkuwcc7 268 24 antagonists antagonist NNS cord-287123-ldkuwcc7 268 25 . . . cord-287123-ldkuwcc7 269 1 CsH CsH NNP cord-287123-ldkuwcc7 269 2 and and CC cord-287123-ldkuwcc7 269 3 another another DT cord-287123-ldkuwcc7 269 4 cyclic cyclic JJ cord-287123-ldkuwcc7 269 5 undecapeptide undecapeptide JJ cord-287123-ldkuwcc7 269 6 CsA CsA NNP cord-287123-ldkuwcc7 269 7 are be VBP cord-287123-ldkuwcc7 269 8 derived derive VBN cord-287123-ldkuwcc7 269 9 from from IN cord-287123-ldkuwcc7 269 10 peptide peptide JJ cord-287123-ldkuwcc7 269 11 metabolites metabolite NNS cord-287123-ldkuwcc7 269 12 of of IN cord-287123-ldkuwcc7 269 13 the the DT cord-287123-ldkuwcc7 269 14 fungus fungus NN cord-287123-ldkuwcc7 269 15 Tolypocladium Tolypocladium NNP cord-287123-ldkuwcc7 269 16 inflatum inflatum NN cord-287123-ldkuwcc7 269 17 [ [ -LRB- cord-287123-ldkuwcc7 269 18 87 87 CD cord-287123-ldkuwcc7 269 19 , , , cord-287123-ldkuwcc7 269 20 144 144 CD cord-287123-ldkuwcc7 269 21 , , , cord-287123-ldkuwcc7 269 22 174 174 CD cord-287123-ldkuwcc7 269 23 ] ] -RRB- cord-287123-ldkuwcc7 269 24 . . . cord-287123-ldkuwcc7 270 1 Several several JJ cord-287123-ldkuwcc7 270 2 cyclosporins cyclosporin NNS cord-287123-ldkuwcc7 270 3 were be VBD cord-287123-ldkuwcc7 270 4 synthesized synthesize VBN cord-287123-ldkuwcc7 270 5 based base VBN cord-287123-ldkuwcc7 270 6 on on IN cord-287123-ldkuwcc7 270 7 CsH CsH NNP cord-287123-ldkuwcc7 270 8 and and CC cord-287123-ldkuwcc7 270 9 SAR SAR NNP cord-287123-ldkuwcc7 270 10 analysis analysis NN cord-287123-ldkuwcc7 270 11 [ [ -LRB- cord-287123-ldkuwcc7 270 12 181 181 CD cord-287123-ldkuwcc7 270 13 ] ] -RRB- cord-287123-ldkuwcc7 270 14 . . . cord-287123-ldkuwcc7 271 1 Competition competition NN cord-287123-ldkuwcc7 271 2 assays assay NNS cord-287123-ldkuwcc7 271 3 conducted conduct VBN cord-287123-ldkuwcc7 271 4 with with IN cord-287123-ldkuwcc7 271 5 radionuclide radionuclide NN cord-287123-ldkuwcc7 271 6 binding binding NN cord-287123-ldkuwcc7 271 7 or or CC cord-287123-ldkuwcc7 271 8 N n NN cord-287123-ldkuwcc7 271 9 - - HYPH cord-287123-ldkuwcc7 271 10 acetyl acetyl NNP cord-287123-ldkuwcc7 272 1 -β -β : cord-287123-ldkuwcc7 272 2 - - HYPH cord-287123-ldkuwcc7 272 3 D D NNP cord-287123-ldkuwcc7 272 4 - - HYPH cord-287123-ldkuwcc7 272 5 glucosaminidase glucosaminidase NN cord-287123-ldkuwcc7 272 6 release release NN cord-287123-ldkuwcc7 272 7 assay assay NN cord-287123-ldkuwcc7 272 8 demonstrated demonstrate VBD cord-287123-ldkuwcc7 272 9 that that IN cord-287123-ldkuwcc7 272 10 cyclosporin cyclosporin NN cord-287123-ldkuwcc7 272 11 H h NN cord-287123-ldkuwcc7 272 12 and and CC cord-287123-ldkuwcc7 272 13 its -PRON- PRP$ cord-287123-ldkuwcc7 272 14 derivatives derivative NNS cord-287123-ldkuwcc7 272 15 are be VBP cord-287123-ldkuwcc7 272 16 potent potent JJ cord-287123-ldkuwcc7 272 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 272 18 antagonists antagonist NNS cord-287123-ldkuwcc7 272 19 with with IN cord-287123-ldkuwcc7 272 20 nanomolar nanomolar NNP cord-287123-ldkuwcc7 272 21 IC IC NNP cord-287123-ldkuwcc7 272 22 50 50 CD cord-287123-ldkuwcc7 272 23 values value NNS cord-287123-ldkuwcc7 272 24 [ [ -LRB- cord-287123-ldkuwcc7 272 25 181 181 CD cord-287123-ldkuwcc7 272 26 , , , cord-287123-ldkuwcc7 272 27 182 182 CD cord-287123-ldkuwcc7 272 28 ] ] -RRB- cord-287123-ldkuwcc7 272 29 . . . cord-287123-ldkuwcc7 273 1 These these DT cord-287123-ldkuwcc7 273 2 compounds compound NNS cord-287123-ldkuwcc7 273 3 were be VBD cord-287123-ldkuwcc7 273 4 shown show VBN cord-287123-ldkuwcc7 273 5 to to TO cord-287123-ldkuwcc7 273 6 be be VB cord-287123-ldkuwcc7 273 7 specific specific JJ cord-287123-ldkuwcc7 273 8 to to IN cord-287123-ldkuwcc7 273 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 273 10 only only RB cord-287123-ldkuwcc7 273 11 at at IN cord-287123-ldkuwcc7 273 12 low low JJ cord-287123-ldkuwcc7 273 13 concentrations concentration NNS cord-287123-ldkuwcc7 273 14 . . . cord-287123-ldkuwcc7 274 1 The the DT cord-287123-ldkuwcc7 274 2 blocking block VBG cord-287123-ldkuwcc7 274 3 effect effect NN cord-287123-ldkuwcc7 274 4 on on IN cord-287123-ldkuwcc7 274 5 FPR2 FPR2 NNP cord-287123-ldkuwcc7 274 6 signaling signal VBG cord-287123-ldkuwcc7 274 7 is be VBZ cord-287123-ldkuwcc7 274 8 also also RB cord-287123-ldkuwcc7 274 9 observed observe VBN cord-287123-ldkuwcc7 274 10 with with IN cord-287123-ldkuwcc7 274 11 CsH CsH NNP cord-287123-ldkuwcc7 274 12 at at IN cord-287123-ldkuwcc7 274 13 high high JJ cord-287123-ldkuwcc7 274 14 concentrations concentration NNS cord-287123-ldkuwcc7 274 15 ( ( -LRB- cord-287123-ldkuwcc7 274 16 > > NFP cord-287123-ldkuwcc7 274 17 2.5 2.5 CD cord-287123-ldkuwcc7 274 18 µM µM NFP cord-287123-ldkuwcc7 274 19 ) ) -RRB- cord-287123-ldkuwcc7 275 1 [ [ -LRB- cord-287123-ldkuwcc7 275 2 174 174 CD cord-287123-ldkuwcc7 275 3 ] ] -RRB- cord-287123-ldkuwcc7 275 4 . . . cord-287123-ldkuwcc7 276 1 It -PRON- PRP cord-287123-ldkuwcc7 276 2 was be VBD cord-287123-ldkuwcc7 276 3 reported report VBN cord-287123-ldkuwcc7 276 4 that that IN cord-287123-ldkuwcc7 276 5 CsH csh NN cord-287123-ldkuwcc7 276 6 could could MD cord-287123-ldkuwcc7 276 7 attenuate attenuate VB cord-287123-ldkuwcc7 276 8 mouse mouse NN cord-287123-ldkuwcc7 276 9 acute acute JJ cord-287123-ldkuwcc7 276 10 inflammation inflammation NN cord-287123-ldkuwcc7 276 11 evoked evoke VBN cord-287123-ldkuwcc7 276 12 by by IN cord-287123-ldkuwcc7 276 13 cigarette cigarette NN cord-287123-ldkuwcc7 276 14 smoking smoking NN cord-287123-ldkuwcc7 276 15 [ [ -LRB- cord-287123-ldkuwcc7 276 16 183 183 CD cord-287123-ldkuwcc7 276 17 ] ] -RRB- cord-287123-ldkuwcc7 276 18 . . . cord-287123-ldkuwcc7 277 1 Another another DT cord-287123-ldkuwcc7 277 2 study study NN cord-287123-ldkuwcc7 277 3 revealed reveal VBD cord-287123-ldkuwcc7 277 4 that that IN cord-287123-ldkuwcc7 277 5 administration administration NN cord-287123-ldkuwcc7 277 6 of of IN cord-287123-ldkuwcc7 277 7 CsH CsH NNP cord-287123-ldkuwcc7 277 8 reduced reduce VBD cord-287123-ldkuwcc7 277 9 opioid opioid JJ cord-287123-ldkuwcc7 277 10 peptide peptide NN cord-287123-ldkuwcc7 277 11 secretion secretion NN cord-287123-ldkuwcc7 277 12 and and CC cord-287123-ldkuwcc7 277 13 analgesia analgesia NN cord-287123-ldkuwcc7 277 14 associated associate VBN cord-287123-ldkuwcc7 277 15 with with IN cord-287123-ldkuwcc7 277 16 neutrophil neutrophil NN cord-287123-ldkuwcc7 277 17 activation activation NN cord-287123-ldkuwcc7 277 18 during during IN cord-287123-ldkuwcc7 277 19 Mycobacteria Mycobacteria NNP cord-287123-ldkuwcc7 277 20 butyricum butyricum NNP cord-287123-ldkuwcc7 277 21 infection infection NN cord-287123-ldkuwcc7 277 22 [ [ -LRB- cord-287123-ldkuwcc7 277 23 184 184 CD cord-287123-ldkuwcc7 277 24 ] ] -RRB- cord-287123-ldkuwcc7 277 25 . . . cord-287123-ldkuwcc7 278 1 CsH CsH NNP cord-287123-ldkuwcc7 278 2 and and CC cord-287123-ldkuwcc7 278 3 derivatives derivative NNS cord-287123-ldkuwcc7 278 4 are be VBP cord-287123-ldkuwcc7 278 5 anticipated anticipate VBN cord-287123-ldkuwcc7 278 6 to to TO cord-287123-ldkuwcc7 278 7 be be VB cord-287123-ldkuwcc7 278 8 useful useful JJ cord-287123-ldkuwcc7 278 9 in in IN cord-287123-ldkuwcc7 278 10 the the DT cord-287123-ldkuwcc7 278 11 treatment treatment NN cord-287123-ldkuwcc7 278 12 of of IN cord-287123-ldkuwcc7 278 13 airway airway NN cord-287123-ldkuwcc7 278 14 , , , cord-287123-ldkuwcc7 278 15 gastrointestinal gastrointestinal JJ cord-287123-ldkuwcc7 278 16 tract tract NN cord-287123-ldkuwcc7 278 17 and and CC cord-287123-ldkuwcc7 278 18 skin skin VB cord-287123-ldkuwcc7 278 19 inflammatory inflammatory JJ cord-287123-ldkuwcc7 278 20 disorders disorder NNS cord-287123-ldkuwcc7 278 21 associated associate VBN cord-287123-ldkuwcc7 278 22 with with IN cord-287123-ldkuwcc7 278 23 neutrophil neutrophil NN cord-287123-ldkuwcc7 278 24 and and CC cord-287123-ldkuwcc7 278 25 eosinophil eosinophil JJ cord-287123-ldkuwcc7 278 26 infiltration infiltration NN cord-287123-ldkuwcc7 278 27 . . . cord-287123-ldkuwcc7 279 1 An an DT cord-287123-ldkuwcc7 279 2 endogenous endogenous JJ cord-287123-ldkuwcc7 279 3 allergen allergen NN cord-287123-ldkuwcc7 279 4 uteroglobin uteroglobin NN cord-287123-ldkuwcc7 279 5 ( ( -LRB- cord-287123-ldkuwcc7 279 6 UG UG NNP cord-287123-ldkuwcc7 279 7 ) ) -RRB- cord-287123-ldkuwcc7 279 8 was be VBD cord-287123-ldkuwcc7 279 9 previously previously RB cord-287123-ldkuwcc7 279 10 identified identify VBN cord-287123-ldkuwcc7 279 11 as as IN cord-287123-ldkuwcc7 279 12 an an DT cord-287123-ldkuwcc7 279 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 279 14 antagonist antagonist NN cord-287123-ldkuwcc7 279 15 . . . cord-287123-ldkuwcc7 280 1 UG UG NNP cord-287123-ldkuwcc7 280 2 , , , cord-287123-ldkuwcc7 280 3 known know VBN cord-287123-ldkuwcc7 280 4 as as IN cord-287123-ldkuwcc7 280 5 Clara Clara NNP cord-287123-ldkuwcc7 280 6 cell cell NN cord-287123-ldkuwcc7 280 7 10 10 CD cord-287123-ldkuwcc7 280 8 kDa kDa NNS cord-287123-ldkuwcc7 280 9 protein protein NN cord-287123-ldkuwcc7 280 10 ( ( -LRB- cord-287123-ldkuwcc7 280 11 CC10 CC10 NNP cord-287123-ldkuwcc7 280 12 ) ) -RRB- cord-287123-ldkuwcc7 280 13 in in IN cord-287123-ldkuwcc7 280 14 humans human NNS cord-287123-ldkuwcc7 280 15 , , , cord-287123-ldkuwcc7 280 16 is be VBZ cord-287123-ldkuwcc7 280 17 an an DT cord-287123-ldkuwcc7 280 18 anti anti JJ cord-287123-ldkuwcc7 280 19 - - JJ cord-287123-ldkuwcc7 280 20 inflammatory inflammatory JJ cord-287123-ldkuwcc7 280 21 and and CC cord-287123-ldkuwcc7 280 22 anti anti JJ cord-287123-ldkuwcc7 280 23 - - JJ cord-287123-ldkuwcc7 280 24 chemotactic chemotactic JJ cord-287123-ldkuwcc7 280 25 protein protein NN cord-287123-ldkuwcc7 280 26 that that WDT cord-287123-ldkuwcc7 280 27 is be VBZ cord-287123-ldkuwcc7 280 28 constitutively constitutively RB cord-287123-ldkuwcc7 280 29 expressed express VBN cord-287123-ldkuwcc7 280 30 in in IN cord-287123-ldkuwcc7 280 31 mammalian mammalian JJ cord-287123-ldkuwcc7 280 32 airway airway NN cord-287123-ldkuwcc7 280 33 epithelium epithelium NN cord-287123-ldkuwcc7 280 34 . . . cord-287123-ldkuwcc7 281 1 Before before IN cord-287123-ldkuwcc7 281 2 molecular molecular JJ cord-287123-ldkuwcc7 281 3 cloning cloning NN cord-287123-ldkuwcc7 281 4 of of IN cord-287123-ldkuwcc7 281 5 FPR fpr NN cord-287123-ldkuwcc7 281 6 , , , cord-287123-ldkuwcc7 281 7 UG UG NNP cord-287123-ldkuwcc7 281 8 was be VBD cord-287123-ldkuwcc7 281 9 found find VBN cord-287123-ldkuwcc7 281 10 to to TO cord-287123-ldkuwcc7 281 11 inhibit inhibit VB cord-287123-ldkuwcc7 281 12 fMLF fmlf JJ cord-287123-ldkuwcc7 281 13 - - HYPH cord-287123-ldkuwcc7 281 14 induced induce VBN cord-287123-ldkuwcc7 281 15 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 281 16 of of IN cord-287123-ldkuwcc7 281 17 monocytes monocyte NNS cord-287123-ldkuwcc7 281 18 and and CC cord-287123-ldkuwcc7 281 19 neutrophils neutrophil NNS cord-287123-ldkuwcc7 281 20 [ [ -LRB- cord-287123-ldkuwcc7 281 21 185 185 CD cord-287123-ldkuwcc7 281 22 ] ] -RRB- cord-287123-ldkuwcc7 281 23 . . . cord-287123-ldkuwcc7 282 1 After after IN cord-287123-ldkuwcc7 282 2 molecular molecular JJ cord-287123-ldkuwcc7 282 3 cloning cloning NN cord-287123-ldkuwcc7 282 4 of of IN cord-287123-ldkuwcc7 282 5 the the DT cord-287123-ldkuwcc7 282 6 FPR FPR NNP cord-287123-ldkuwcc7 282 7 genes gene NNS cord-287123-ldkuwcc7 282 8 , , , cord-287123-ldkuwcc7 282 9 the the DT cord-287123-ldkuwcc7 282 10 high high JJ cord-287123-ldkuwcc7 282 11 affinity affinity NN cord-287123-ldkuwcc7 282 12 binding binding NN cord-287123-ldkuwcc7 282 13 of of IN cord-287123-ldkuwcc7 282 14 UG UG NNP cord-287123-ldkuwcc7 282 15 to to IN cord-287123-ldkuwcc7 282 16 FPR2 FPR2 NNP cord-287123-ldkuwcc7 282 17 was be VBD cord-287123-ldkuwcc7 282 18 determined determine VBN cord-287123-ldkuwcc7 282 19 with with IN cord-287123-ldkuwcc7 282 20 a a DT cord-287123-ldkuwcc7 282 21 K K NNP cord-287123-ldkuwcc7 282 22 d d NN cord-287123-ldkuwcc7 282 23 of of IN cord-287123-ldkuwcc7 282 24 33 33 CD cord-287123-ldkuwcc7 282 25 nM nm CD cord-287123-ldkuwcc7 282 26 in in IN cord-287123-ldkuwcc7 282 27 HEK293 HEK293 NNP cord-287123-ldkuwcc7 282 28 cells cell NNS cord-287123-ldkuwcc7 282 29 stably stably RB cord-287123-ldkuwcc7 282 30 expressing express VBG cord-287123-ldkuwcc7 282 31 FPR2 FPR2 NNP cord-287123-ldkuwcc7 282 32 [ [ -LRB- cord-287123-ldkuwcc7 282 33 86 86 CD cord-287123-ldkuwcc7 282 34 ] ] -RRB- cord-287123-ldkuwcc7 282 35 . . . cord-287123-ldkuwcc7 283 1 The the DT cord-287123-ldkuwcc7 283 2 interaction interaction NN cord-287123-ldkuwcc7 283 3 of of IN cord-287123-ldkuwcc7 283 4 UG UG NNP cord-287123-ldkuwcc7 283 5 with with IN cord-287123-ldkuwcc7 283 6 FPR2 FPR2 NNP cord-287123-ldkuwcc7 283 7 inhibits inhibit VBZ cord-287123-ldkuwcc7 283 8 SAA SAA NNP cord-287123-ldkuwcc7 283 9 expression expression NN cord-287123-ldkuwcc7 283 10 and and CC cord-287123-ldkuwcc7 283 11 SAA SAA NNP cord-287123-ldkuwcc7 283 12 - - HYPH cord-287123-ldkuwcc7 283 13 driven drive VBN cord-287123-ldkuwcc7 283 14 inflammation inflammation NN cord-287123-ldkuwcc7 283 15 [ [ -LRB- cord-287123-ldkuwcc7 283 16 86 86 CD cord-287123-ldkuwcc7 283 17 , , , cord-287123-ldkuwcc7 283 18 186 186 CD cord-287123-ldkuwcc7 283 19 ] ] -RRB- cord-287123-ldkuwcc7 283 20 . . . cord-287123-ldkuwcc7 284 1 The the DT cord-287123-ldkuwcc7 284 2 activity activity NN cord-287123-ldkuwcc7 284 3 of of IN cord-287123-ldkuwcc7 284 4 UG UG NNP cord-287123-ldkuwcc7 284 5 at at IN cord-287123-ldkuwcc7 284 6 FPR1 FPR1 NNP cord-287123-ldkuwcc7 284 7 or or CC cord-287123-ldkuwcc7 284 8 other other JJ cord-287123-ldkuwcc7 284 9 receptors receptor NNS cord-287123-ldkuwcc7 284 10 has have VBZ cord-287123-ldkuwcc7 284 11 not not RB cord-287123-ldkuwcc7 284 12 been be VBN cord-287123-ldkuwcc7 284 13 examined examine VBN cord-287123-ldkuwcc7 284 14 yet yet RB cord-287123-ldkuwcc7 284 15 , , , cord-287123-ldkuwcc7 284 16 thus thus RB cord-287123-ldkuwcc7 284 17 the the DT cord-287123-ldkuwcc7 284 18 selectivity selectivity NN cord-287123-ldkuwcc7 284 19 of of IN cord-287123-ldkuwcc7 284 20 this this DT cord-287123-ldkuwcc7 284 21 allergen allergen NN cord-287123-ldkuwcc7 284 22 is be VBZ cord-287123-ldkuwcc7 284 23 not not RB cord-287123-ldkuwcc7 284 24 fully fully RB cord-287123-ldkuwcc7 284 25 understood understand VBN cord-287123-ldkuwcc7 284 26 . . . cord-287123-ldkuwcc7 285 1 An an DT cord-287123-ldkuwcc7 285 2 additional additional JJ cord-287123-ldkuwcc7 285 3 natural natural JJ cord-287123-ldkuwcc7 285 4 peptide peptide NN cord-287123-ldkuwcc7 285 5 with with IN cord-287123-ldkuwcc7 285 6 antagonistic antagonistic JJ cord-287123-ldkuwcc7 285 7 activity activity NN cord-287123-ldkuwcc7 285 8 is be VBZ cord-287123-ldkuwcc7 285 9 a a DT cord-287123-ldkuwcc7 285 10 urokinase urokinase NN cord-287123-ldkuwcc7 285 11 receptor receptor NN cord-287123-ldkuwcc7 285 12 - - HYPH cord-287123-ldkuwcc7 285 13 derived derive VBN cord-287123-ldkuwcc7 285 14 cyclic cyclic JJ cord-287123-ldkuwcc7 285 15 peptide peptide NN cord-287123-ldkuwcc7 285 16 . . . cord-287123-ldkuwcc7 286 1 Note note VB cord-287123-ldkuwcc7 286 2 that that IN cord-287123-ldkuwcc7 286 3 the the DT cord-287123-ldkuwcc7 286 4 linear linear JJ cord-287123-ldkuwcc7 286 5 form form NN cord-287123-ldkuwcc7 286 6 of of IN cord-287123-ldkuwcc7 286 7 this this DT cord-287123-ldkuwcc7 286 8 peptide peptide NN cord-287123-ldkuwcc7 286 9 88 88 CD cord-287123-ldkuwcc7 286 10 Ser Ser NNP cord-287123-ldkuwcc7 286 11 - - HYPH cord-287123-ldkuwcc7 286 12 Arg arg JJ cord-287123-ldkuwcc7 286 13 - - HYPH cord-287123-ldkuwcc7 286 14 Ser ser JJ cord-287123-ldkuwcc7 286 15 - - HYPH cord-287123-ldkuwcc7 286 16 Arg Arg NNP cord-287123-ldkuwcc7 286 17 - - HYPH cord-287123-ldkuwcc7 286 18 Tyr Tyr NNP cord-287123-ldkuwcc7 286 19 92 92 CD cord-287123-ldkuwcc7 286 20 is be VBZ cord-287123-ldkuwcc7 286 21 actually actually RB cord-287123-ldkuwcc7 286 22 a a DT cord-287123-ldkuwcc7 286 23 dual dual JJ cord-287123-ldkuwcc7 286 24 agonist agonist NN cord-287123-ldkuwcc7 286 25 for for IN cord-287123-ldkuwcc7 286 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 286 27 and and CC cord-287123-ldkuwcc7 286 28 FPR2 FPR2 NNP cord-287123-ldkuwcc7 286 29 [ [ -LRB- cord-287123-ldkuwcc7 286 30 62 62 CD cord-287123-ldkuwcc7 286 31 ] ] -RRB- cord-287123-ldkuwcc7 286 32 . . . cord-287123-ldkuwcc7 287 1 The the DT cord-287123-ldkuwcc7 287 2 cyclized cyclized JJ cord-287123-ldkuwcc7 287 3 SRSRY SRSRY NNP cord-287123-ldkuwcc7 287 4 was be VBD cord-287123-ldkuwcc7 287 5 reported report VBN cord-287123-ldkuwcc7 287 6 to to TO cord-287123-ldkuwcc7 287 7 inhibit inhibit VB cord-287123-ldkuwcc7 287 8 the the DT cord-287123-ldkuwcc7 287 9 binding binding NN cord-287123-ldkuwcc7 287 10 of of IN cord-287123-ldkuwcc7 287 11 fluorescence fluorescence NN cord-287123-ldkuwcc7 287 12 labeled label VBD cord-287123-ldkuwcc7 287 13 fMLF fmlf NN cord-287123-ldkuwcc7 287 14 to to IN cord-287123-ldkuwcc7 287 15 FPR1-expressing fpr1-expresse VBG cord-287123-ldkuwcc7 287 16 RBL-2H3 rbl-2h3 CD cord-287123-ldkuwcc7 287 17 cells cell NNS cord-287123-ldkuwcc7 287 18 and and CC cord-287123-ldkuwcc7 287 19 it -PRON- PRP cord-287123-ldkuwcc7 287 20 inhibits inhibit VBZ cord-287123-ldkuwcc7 287 21 fMLF fmlf PRP cord-287123-ldkuwcc7 287 22 - - HYPH cord-287123-ldkuwcc7 287 23 directed direct VBN cord-287123-ldkuwcc7 287 24 monocyte monocyte NNP cord-287123-ldkuwcc7 287 25 migration migration NN cord-287123-ldkuwcc7 287 26 with with IN cord-287123-ldkuwcc7 287 27 a a DT cord-287123-ldkuwcc7 287 28 picomolar picomolar JJ cord-287123-ldkuwcc7 287 29 IC IC NNP cord-287123-ldkuwcc7 287 30 50 50 CD cord-287123-ldkuwcc7 287 31 [ [ -LRB- cord-287123-ldkuwcc7 287 32 88 88 CD cord-287123-ldkuwcc7 287 33 ] ] -RRB- cord-287123-ldkuwcc7 287 34 . . . cord-287123-ldkuwcc7 288 1 However however RB cord-287123-ldkuwcc7 288 2 , , , cord-287123-ldkuwcc7 288 3 the the DT cord-287123-ldkuwcc7 288 4 activity activity NN cord-287123-ldkuwcc7 288 5 of of IN cord-287123-ldkuwcc7 288 6 cyclized cyclize VBN cord-287123-ldkuwcc7 288 7 SRSRY SRSRY NNP cord-287123-ldkuwcc7 288 8 on on IN cord-287123-ldkuwcc7 288 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 288 10 was be VBD cord-287123-ldkuwcc7 288 11 not not RB cord-287123-ldkuwcc7 288 12 verified verify VBN cord-287123-ldkuwcc7 288 13 in in IN cord-287123-ldkuwcc7 288 14 the the DT cord-287123-ldkuwcc7 288 15 study study NN cord-287123-ldkuwcc7 288 16 . . . cord-287123-ldkuwcc7 289 1 An an DT cord-287123-ldkuwcc7 289 2 extract extract NN cord-287123-ldkuwcc7 289 3 of of IN cord-287123-ldkuwcc7 289 4 secondary secondary JJ cord-287123-ldkuwcc7 289 5 metabolites metabolite NNS cord-287123-ldkuwcc7 289 6 from from IN cord-287123-ldkuwcc7 289 7 a a DT cord-287123-ldkuwcc7 289 8 marine marine JJ cord-287123-ldkuwcc7 289 9 Bacillus bacillus NN cord-287123-ldkuwcc7 289 10 sp sp NN cord-287123-ldkuwcc7 289 11 . . . cord-287123-ldkuwcc7 289 12 was be VBD cord-287123-ldkuwcc7 289 13 also also RB cord-287123-ldkuwcc7 289 14 found find VBN cord-287123-ldkuwcc7 289 15 to to TO cord-287123-ldkuwcc7 289 16 have have VB cord-287123-ldkuwcc7 289 17 FPR fpr NN cord-287123-ldkuwcc7 289 18 antagonistic antagonistic JJ cord-287123-ldkuwcc7 289 19 properties property NNS cord-287123-ldkuwcc7 289 20 [ [ -LRB- cord-287123-ldkuwcc7 289 21 187 187 CD cord-287123-ldkuwcc7 289 22 ] ] -RRB- cord-287123-ldkuwcc7 289 23 . . . cord-287123-ldkuwcc7 290 1 The the DT cord-287123-ldkuwcc7 290 2 precise precise JJ cord-287123-ldkuwcc7 290 3 molecule molecule NN cord-287123-ldkuwcc7 290 4 responsible responsible JJ cord-287123-ldkuwcc7 290 5 for for IN cord-287123-ldkuwcc7 290 6 the the DT cord-287123-ldkuwcc7 290 7 inhibitory inhibitory JJ cord-287123-ldkuwcc7 290 8 activity activity NN cord-287123-ldkuwcc7 290 9 has have VBZ cord-287123-ldkuwcc7 290 10 not not RB cord-287123-ldkuwcc7 290 11 yet yet RB cord-287123-ldkuwcc7 290 12 been be VBN cord-287123-ldkuwcc7 290 13 identified identify VBN cord-287123-ldkuwcc7 290 14 . . . cord-287123-ldkuwcc7 291 1 Other other JJ cord-287123-ldkuwcc7 291 2 endogenous endogenous JJ cord-287123-ldkuwcc7 291 3 non non JJ cord-287123-ldkuwcc7 291 4 - - JJ cord-287123-ldkuwcc7 291 5 cyclized cyclized JJ cord-287123-ldkuwcc7 291 6 peptides peptide NNS cord-287123-ldkuwcc7 291 7 with with IN cord-287123-ldkuwcc7 291 8 antagonistic antagonistic JJ cord-287123-ldkuwcc7 291 9 activity activity NN cord-287123-ldkuwcc7 291 10 include include VBP cord-287123-ldkuwcc7 291 11 spinorphin spinorphin NNP cord-287123-ldkuwcc7 291 12 ( ( -LRB- cord-287123-ldkuwcc7 291 13 LVVYPWT LVVYPWT NNP cord-287123-ldkuwcc7 291 14 ) ) -RRB- cord-287123-ldkuwcc7 291 15 [ [ -LRB- cord-287123-ldkuwcc7 291 16 188 188 CD cord-287123-ldkuwcc7 291 17 ] ] -RRB- cord-287123-ldkuwcc7 291 18 and and CC cord-287123-ldkuwcc7 291 19 sarpopeptate sarpopeptate NNP cord-287123-ldkuwcc7 291 20 , , , cord-287123-ldkuwcc7 291 21 an an DT cord-287123-ldkuwcc7 291 22 aurantiamide aurantiamide NN cord-287123-ldkuwcc7 291 23 isolated isolate VBN cord-287123-ldkuwcc7 291 24 from from IN cord-287123-ldkuwcc7 291 25 plants plant NNS cord-287123-ldkuwcc7 291 26 and and CC cord-287123-ldkuwcc7 291 27 fungi fungus NNS cord-287123-ldkuwcc7 291 28 [ [ -LRB- cord-287123-ldkuwcc7 291 29 189 189 CD cord-287123-ldkuwcc7 291 30 ] ] -RRB- cord-287123-ldkuwcc7 291 31 . . . cord-287123-ldkuwcc7 292 1 Spinorphin Spinorphin NNP cord-287123-ldkuwcc7 292 2 is be VBZ cord-287123-ldkuwcc7 292 3 an an DT cord-287123-ldkuwcc7 292 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 292 5 antagonist antagonist NN cord-287123-ldkuwcc7 292 6 [ [ -LRB- cord-287123-ldkuwcc7 292 7 188 188 CD cord-287123-ldkuwcc7 292 8 , , , cord-287123-ldkuwcc7 292 9 190 190 CD cord-287123-ldkuwcc7 292 10 ] ] -RRB- cord-287123-ldkuwcc7 292 11 . . . cord-287123-ldkuwcc7 293 1 Sarpopeptate Sarpopeptate NNP cord-287123-ldkuwcc7 293 2 and and CC cord-287123-ldkuwcc7 293 3 its -PRON- PRP$ cord-287123-ldkuwcc7 293 4 dipeptide dipeptide NN cord-287123-ldkuwcc7 293 5 derivatives derivative NNS cord-287123-ldkuwcc7 293 6 were be VBD cord-287123-ldkuwcc7 293 7 shown show VBN cord-287123-ldkuwcc7 293 8 to to TO cord-287123-ldkuwcc7 293 9 have have VB cord-287123-ldkuwcc7 293 10 potent potent JJ cord-287123-ldkuwcc7 293 11 inhibitory inhibitory JJ cord-287123-ldkuwcc7 293 12 effects effect NNS cord-287123-ldkuwcc7 293 13 on on IN cord-287123-ldkuwcc7 293 14 fMLF fmlf RB cord-287123-ldkuwcc7 293 15 - - HYPH cord-287123-ldkuwcc7 293 16 stimulated stimulate VBN cord-287123-ldkuwcc7 293 17 neutrophil neutrophil NN cord-287123-ldkuwcc7 293 18 responses response NNS cord-287123-ldkuwcc7 293 19 [ [ -LRB- cord-287123-ldkuwcc7 293 20 191 191 CD cord-287123-ldkuwcc7 293 21 , , , cord-287123-ldkuwcc7 293 22 192 192 CD cord-287123-ldkuwcc7 293 23 ] ] -RRB- cord-287123-ldkuwcc7 293 24 and and CC cord-287123-ldkuwcc7 293 25 exhibit exhibit VB cord-287123-ldkuwcc7 293 26 a a DT cord-287123-ldkuwcc7 293 27 receptor receptor NN cord-287123-ldkuwcc7 293 28 preference preference NN cord-287123-ldkuwcc7 293 29 for for IN cord-287123-ldkuwcc7 293 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 293 31 over over IN cord-287123-ldkuwcc7 293 32 FPR2 FPR2 NNP cord-287123-ldkuwcc7 293 33 [ [ -LRB- cord-287123-ldkuwcc7 293 34 193 193 CD cord-287123-ldkuwcc7 293 35 ] ] -RRB- cord-287123-ldkuwcc7 293 36 . . . cord-287123-ldkuwcc7 294 1 However however RB cord-287123-ldkuwcc7 294 2 , , , cord-287123-ldkuwcc7 294 3 the the DT cord-287123-ldkuwcc7 294 4 receptor receptor NN cord-287123-ldkuwcc7 294 5 specificity specificity NN cord-287123-ldkuwcc7 294 6 needs need VBZ cord-287123-ldkuwcc7 294 7 further further JJ cord-287123-ldkuwcc7 294 8 identification identification NN cord-287123-ldkuwcc7 294 9 because because IN cord-287123-ldkuwcc7 294 10 of of IN cord-287123-ldkuwcc7 294 11 the the DT cord-287123-ldkuwcc7 294 12 lack lack NN cord-287123-ldkuwcc7 294 13 of of IN cord-287123-ldkuwcc7 294 14 data datum NNS cord-287123-ldkuwcc7 294 15 for for IN cord-287123-ldkuwcc7 294 16 binding bind VBG cord-287123-ldkuwcc7 294 17 analysis analysis NN cord-287123-ldkuwcc7 294 18 . . . cord-287123-ldkuwcc7 295 1 In in IN cord-287123-ldkuwcc7 295 2 a a DT cord-287123-ldkuwcc7 295 3 ligand ligand NN cord-287123-ldkuwcc7 295 4 screen screen NN cord-287123-ldkuwcc7 295 5 of of IN cord-287123-ldkuwcc7 295 6 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 295 7 libraries library NNS cord-287123-ldkuwcc7 295 8 , , , cord-287123-ldkuwcc7 295 9 several several JJ cord-287123-ldkuwcc7 295 10 peptides peptide NNS cord-287123-ldkuwcc7 295 11 were be VBD cord-287123-ldkuwcc7 295 12 found find VBN cord-287123-ldkuwcc7 295 13 to to TO cord-287123-ldkuwcc7 295 14 inhibit inhibit VB cord-287123-ldkuwcc7 295 15 the the DT cord-287123-ldkuwcc7 295 16 binding binding NN cord-287123-ldkuwcc7 295 17 of of IN cord-287123-ldkuwcc7 295 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 295 19 agonist agonist NN cord-287123-ldkuwcc7 295 20 WKYMVm WKYMVm NNS cord-287123-ldkuwcc7 295 21 . . . cord-287123-ldkuwcc7 296 1 The the DT cord-287123-ldkuwcc7 296 2 peptide peptide NN cord-287123-ldkuwcc7 296 3 WRWWWW WRWWWW NNP cord-287123-ldkuwcc7 296 4 ( ( -LRB- cord-287123-ldkuwcc7 296 5 WRW WRW NNP cord-287123-ldkuwcc7 296 6 4 4 CD cord-287123-ldkuwcc7 296 7 ) ) -RRB- cord-287123-ldkuwcc7 296 8 is be VBZ cord-287123-ldkuwcc7 296 9 the the DT cord-287123-ldkuwcc7 296 10 most most RBS cord-287123-ldkuwcc7 296 11 potent potent JJ cord-287123-ldkuwcc7 296 12 of of IN cord-287123-ldkuwcc7 296 13 these these DT cord-287123-ldkuwcc7 296 14 peptides peptide NNS cord-287123-ldkuwcc7 296 15 with with IN cord-287123-ldkuwcc7 296 16 antagonistic antagonistic JJ cord-287123-ldkuwcc7 296 17 activity activity NN cord-287123-ldkuwcc7 296 18 against against IN cord-287123-ldkuwcc7 296 19 FPR2 FPR2 NNP cord-287123-ldkuwcc7 296 20 agonists agonist NNS cord-287123-ldkuwcc7 296 21 [ [ -LRB- cord-287123-ldkuwcc7 296 22 89 89 CD cord-287123-ldkuwcc7 296 23 ] ] -RRB- cord-287123-ldkuwcc7 296 24 . . . cord-287123-ldkuwcc7 297 1 In in IN cord-287123-ldkuwcc7 297 2 addition addition NN cord-287123-ldkuwcc7 297 3 , , , cord-287123-ldkuwcc7 297 4 WRW4 WRW4 NNP cord-287123-ldkuwcc7 297 5 is be VBZ cord-287123-ldkuwcc7 297 6 the the DT cord-287123-ldkuwcc7 297 7 first first JJ cord-287123-ldkuwcc7 297 8 FPR3 FPR3 NNP cord-287123-ldkuwcc7 297 9 antagonist antagonist NN cord-287123-ldkuwcc7 297 10 that that WDT cord-287123-ldkuwcc7 297 11 can can MD cord-287123-ldkuwcc7 297 12 completely completely RB cord-287123-ldkuwcc7 297 13 inhibit inhibit VB cord-287123-ldkuwcc7 297 14 the the DT cord-287123-ldkuwcc7 297 15 activation activation NN cord-287123-ldkuwcc7 297 16 of of IN cord-287123-ldkuwcc7 297 17 FPR3 FPR3 NNP cord-287123-ldkuwcc7 297 18 by by IN cord-287123-ldkuwcc7 297 19 F2L F2L NNP cord-287123-ldkuwcc7 297 20 in in IN cord-287123-ldkuwcc7 297 21 FPR3-transfected FPR3-transfected NNP cord-287123-ldkuwcc7 297 22 HEK293 HEK293 NNP cord-287123-ldkuwcc7 297 23 cells cell NNS cord-287123-ldkuwcc7 297 24 [ [ -LRB- cord-287123-ldkuwcc7 297 25 194 194 CD cord-287123-ldkuwcc7 297 26 ] ] -RRB- cord-287123-ldkuwcc7 297 27 . . . cord-287123-ldkuwcc7 298 1 It -PRON- PRP cord-287123-ldkuwcc7 298 2 inhibits inhibit VBZ cord-287123-ldkuwcc7 298 3 F2L f2l JJ cord-287123-ldkuwcc7 298 4 - - HYPH cord-287123-ldkuwcc7 298 5 induced induce VBN cord-287123-ldkuwcc7 298 6 response response NN cord-287123-ldkuwcc7 298 7 in in IN cord-287123-ldkuwcc7 298 8 mature mature JJ cord-287123-ldkuwcc7 298 9 monocyte monocyte NN cord-287123-ldkuwcc7 298 10 - - HYPH cord-287123-ldkuwcc7 298 11 derived derive VBN cord-287123-ldkuwcc7 298 12 dendritic dendritic JJ cord-287123-ldkuwcc7 298 13 cells cell NNS cord-287123-ldkuwcc7 298 14 , , , cord-287123-ldkuwcc7 298 15 which which WDT cord-287123-ldkuwcc7 298 16 express express VBP cord-287123-ldkuwcc7 298 17 FPR3 FPR3 NNP cord-287123-ldkuwcc7 298 18 but but CC cord-287123-ldkuwcc7 298 19 not not RB cord-287123-ldkuwcc7 298 20 other other JJ cord-287123-ldkuwcc7 298 21 FPRs fpr NNS cord-287123-ldkuwcc7 298 22 . . . cord-287123-ldkuwcc7 299 1 Recently recently RB cord-287123-ldkuwcc7 299 2 , , , cord-287123-ldkuwcc7 299 3 a a DT cord-287123-ldkuwcc7 299 4 cell cell NN cord-287123-ldkuwcc7 299 5 permeable permeable JJ cord-287123-ldkuwcc7 299 6 peptide peptide NN cord-287123-ldkuwcc7 299 7 of of IN cord-287123-ldkuwcc7 299 8 10 10 CD cord-287123-ldkuwcc7 299 9 amino amino NN cord-287123-ldkuwcc7 299 10 acids acid NNS cord-287123-ldkuwcc7 299 11 conjugated conjugate VBN cord-287123-ldkuwcc7 299 12 with with IN cord-287123-ldkuwcc7 299 13 a a DT cord-287123-ldkuwcc7 299 14 rhodamine rhodamine JJ cord-287123-ldkuwcc7 299 15 group group NN cord-287123-ldkuwcc7 299 16 ( ( -LRB- cord-287123-ldkuwcc7 299 17 RhoB RhoB NNP cord-287123-ldkuwcc7 299 18 - - HYPH cord-287123-ldkuwcc7 299 19 QRLFQVKGRR QRLFQVKGRR NNP cord-287123-ldkuwcc7 299 20 , , , cord-287123-ldkuwcc7 299 21 PBP10 PBP10 NNP cord-287123-ldkuwcc7 299 22 ) ) -RRB- cord-287123-ldkuwcc7 299 23 was be VBD cord-287123-ldkuwcc7 299 24 shown show VBN cord-287123-ldkuwcc7 299 25 to to TO cord-287123-ldkuwcc7 299 26 have have VB cord-287123-ldkuwcc7 299 27 potent potent JJ cord-287123-ldkuwcc7 299 28 inhibitory inhibitory JJ cord-287123-ldkuwcc7 299 29 activity activity NN cord-287123-ldkuwcc7 299 30 on on IN cord-287123-ldkuwcc7 299 31 FPR2 FPR2 NNP cord-287123-ldkuwcc7 299 32 . . . cord-287123-ldkuwcc7 300 1 The the DT cord-287123-ldkuwcc7 300 2 peptide peptide JJ cord-287123-ldkuwcc7 300 3 sequence sequence NN cord-287123-ldkuwcc7 300 4 of of IN cord-287123-ldkuwcc7 300 5 PBP10 PBP10 NNP cord-287123-ldkuwcc7 300 6 is be VBZ cord-287123-ldkuwcc7 300 7 derived derive VBN cord-287123-ldkuwcc7 300 8 from from IN cord-287123-ldkuwcc7 300 9 PIP2-binding pip2-binde VBG cord-287123-ldkuwcc7 300 10 domains domain NNS cord-287123-ldkuwcc7 300 11 of of IN cord-287123-ldkuwcc7 300 12 the the DT cord-287123-ldkuwcc7 300 13 cytoskeletal cytoskeletal JJ cord-287123-ldkuwcc7 300 14 protein protein NN cord-287123-ldkuwcc7 300 15 gelsolin gelsolin NN cord-287123-ldkuwcc7 300 16 , , , cord-287123-ldkuwcc7 300 17 and and CC cord-287123-ldkuwcc7 300 18 the the DT cord-287123-ldkuwcc7 300 19 rhodamine rhodamine NN cord-287123-ldkuwcc7 300 20 group group NN cord-287123-ldkuwcc7 300 21 is be VBZ cord-287123-ldkuwcc7 300 22 essential essential JJ cord-287123-ldkuwcc7 300 23 for for IN cord-287123-ldkuwcc7 300 24 the the DT cord-287123-ldkuwcc7 300 25 peptide peptide NN cord-287123-ldkuwcc7 300 26 to to TO cord-287123-ldkuwcc7 300 27 pass pass VB cord-287123-ldkuwcc7 300 28 through through IN cord-287123-ldkuwcc7 300 29 plasma plasma NN cord-287123-ldkuwcc7 300 30 membrane membrane NN cord-287123-ldkuwcc7 300 31 and and CC cord-287123-ldkuwcc7 300 32 exert exert VB cord-287123-ldkuwcc7 300 33 antagonistic antagonistic JJ cord-287123-ldkuwcc7 300 34 activity activity NN cord-287123-ldkuwcc7 300 35 . . . cord-287123-ldkuwcc7 301 1 This this DT cord-287123-ldkuwcc7 301 2 rhodamine rhodamine NN cord-287123-ldkuwcc7 301 3 - - HYPH cord-287123-ldkuwcc7 301 4 linked link VBN cord-287123-ldkuwcc7 301 5 decapeptide decapeptide NN cord-287123-ldkuwcc7 301 6 can can MD cord-287123-ldkuwcc7 301 7 completely completely RB cord-287123-ldkuwcc7 301 8 inhibit inhibit VB cord-287123-ldkuwcc7 301 9 ROS ROS NNP cord-287123-ldkuwcc7 301 10 production production NN cord-287123-ldkuwcc7 301 11 mediated mediate VBN cord-287123-ldkuwcc7 301 12 by by IN cord-287123-ldkuwcc7 301 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 301 14 but but CC cord-287123-ldkuwcc7 301 15 not not RB cord-287123-ldkuwcc7 301 16 by by IN cord-287123-ldkuwcc7 301 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 301 18 [ [ -LRB- cord-287123-ldkuwcc7 301 19 90 90 CD cord-287123-ldkuwcc7 301 20 ] ] -RRB- cord-287123-ldkuwcc7 301 21 . . . cord-287123-ldkuwcc7 302 1 In in IN cord-287123-ldkuwcc7 302 2 a a DT cord-287123-ldkuwcc7 302 3 shorter short JJR cord-287123-ldkuwcc7 302 4 form form NN cord-287123-ldkuwcc7 302 5 , , , cord-287123-ldkuwcc7 302 6 RhoB RhoB NNP cord-287123-ldkuwcc7 302 7 - - HYPH cord-287123-ldkuwcc7 302 8 QRLFQVG QRLFQVG NNP cord-287123-ldkuwcc7 302 9 maintains maintain VBZ cord-287123-ldkuwcc7 302 10 potent potent JJ cord-287123-ldkuwcc7 302 11 antagonistic antagonistic JJ cord-287123-ldkuwcc7 302 12 activity activity NN cord-287123-ldkuwcc7 302 13 for for IN cord-287123-ldkuwcc7 302 14 FPR2 FPR2 NNP cord-287123-ldkuwcc7 302 15 and and CC cord-287123-ldkuwcc7 302 16 displays display VBZ cord-287123-ldkuwcc7 302 17 the the DT cord-287123-ldkuwcc7 302 18 ability ability NN cord-287123-ldkuwcc7 302 19 to to TO cord-287123-ldkuwcc7 302 20 partially partially RB cord-287123-ldkuwcc7 302 21 inhibit inhibit VB cord-287123-ldkuwcc7 302 22 FPR1 FPR1 NNP cord-287123-ldkuwcc7 302 23 . . . cord-287123-ldkuwcc7 303 1 Since since IN cord-287123-ldkuwcc7 303 2 PBP PBP NNP cord-287123-ldkuwcc7 303 3 peptides peptide NNS cord-287123-ldkuwcc7 303 4 bind bind VBP cord-287123-ldkuwcc7 303 5 to to IN cord-287123-ldkuwcc7 303 6 the the DT cord-287123-ldkuwcc7 303 7 intracellular intracellular JJ cord-287123-ldkuwcc7 303 8 domain domain NN cord-287123-ldkuwcc7 303 9 of of IN cord-287123-ldkuwcc7 303 10 receptors receptor NNS cord-287123-ldkuwcc7 303 11 , , , cord-287123-ldkuwcc7 303 12 the the DT cord-287123-ldkuwcc7 303 13 difference difference NN cord-287123-ldkuwcc7 303 14 in in IN cord-287123-ldkuwcc7 303 15 length length NN cord-287123-ldkuwcc7 303 16 may may MD cord-287123-ldkuwcc7 303 17 reflect reflect VB cord-287123-ldkuwcc7 303 18 divergent divergent JJ cord-287123-ldkuwcc7 303 19 structural structural JJ cord-287123-ldkuwcc7 303 20 features feature NNS cord-287123-ldkuwcc7 303 21 of of IN cord-287123-ldkuwcc7 303 22 the the DT cord-287123-ldkuwcc7 303 23 cytosolic cytosolic JJ cord-287123-ldkuwcc7 303 24 side side NN cord-287123-ldkuwcc7 303 25 of of IN cord-287123-ldkuwcc7 303 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 303 27 and and CC cord-287123-ldkuwcc7 303 28 FPR2 FPR2 NNP cord-287123-ldkuwcc7 303 29 . . . cord-287123-ldkuwcc7 304 1 It -PRON- PRP cord-287123-ldkuwcc7 304 2 is be VBZ cord-287123-ldkuwcc7 304 3 notable notable JJ cord-287123-ldkuwcc7 304 4 that that IN cord-287123-ldkuwcc7 304 5 PBP10 PBP10 NNP cord-287123-ldkuwcc7 304 6 is be VBZ cord-287123-ldkuwcc7 304 7 not not RB cord-287123-ldkuwcc7 304 8 an an DT cord-287123-ldkuwcc7 304 9 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 304 10 antagonist antagonist NN cord-287123-ldkuwcc7 304 11 as as IN cord-287123-ldkuwcc7 304 12 it -PRON- PRP cord-287123-ldkuwcc7 304 13 also also RB cord-287123-ldkuwcc7 304 14 affects affect VBZ cord-287123-ldkuwcc7 304 15 non non JJ cord-287123-ldkuwcc7 304 16 - - JJ cord-287123-ldkuwcc7 304 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 304 18 mediated mediate VBD cord-287123-ldkuwcc7 304 19 signaling signal VBG cord-287123-ldkuwcc7 304 20 [ [ -LRB- cord-287123-ldkuwcc7 304 21 90 90 CD cord-287123-ldkuwcc7 304 22 ] ] -RRB- cord-287123-ldkuwcc7 304 23 . . . cord-287123-ldkuwcc7 305 1 The the DT cord-287123-ldkuwcc7 305 2 pepducin pepducin NNS cord-287123-ldkuwcc7 305 3 F1Pal16 F1Pal16 NNP cord-287123-ldkuwcc7 305 4 , , , cord-287123-ldkuwcc7 305 5 derived derive VBN cord-287123-ldkuwcc7 305 6 from from IN cord-287123-ldkuwcc7 305 7 a a DT cord-287123-ldkuwcc7 305 8 segment segment NN cord-287123-ldkuwcc7 305 9 of of IN cord-287123-ldkuwcc7 305 10 the the DT cord-287123-ldkuwcc7 305 11 third third JJ cord-287123-ldkuwcc7 305 12 intracellular intracellular JJ cord-287123-ldkuwcc7 305 13 loop loop NN cord-287123-ldkuwcc7 305 14 of of IN cord-287123-ldkuwcc7 305 15 FPR1 FPR1 NNP cord-287123-ldkuwcc7 305 16 , , , cord-287123-ldkuwcc7 305 17 was be VBD cord-287123-ldkuwcc7 305 18 found find VBN cord-287123-ldkuwcc7 305 19 to to TO cord-287123-ldkuwcc7 305 20 inhibit inhibit VB cord-287123-ldkuwcc7 305 21 FPR2-mediated fpr2-mediated JJ cord-287123-ldkuwcc7 305 22 cellular cellular JJ cord-287123-ldkuwcc7 305 23 response response NN cord-287123-ldkuwcc7 305 24 , , , cord-287123-ldkuwcc7 305 25 but but CC cord-287123-ldkuwcc7 305 26 had have VBD cord-287123-ldkuwcc7 305 27 no no DT cord-287123-ldkuwcc7 305 28 effect effect NN cord-287123-ldkuwcc7 305 29 on on IN cord-287123-ldkuwcc7 305 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 305 31 signaling signal VBG cord-287123-ldkuwcc7 305 32 [ [ -LRB- cord-287123-ldkuwcc7 305 33 91 91 CD cord-287123-ldkuwcc7 305 34 ] ] -RRB- cord-287123-ldkuwcc7 305 35 . . . cord-287123-ldkuwcc7 306 1 The the DT cord-287123-ldkuwcc7 306 2 FPR2 FPR2 NNP cord-287123-ldkuwcc7 306 3 antagonistic antagonistic JJ cord-287123-ldkuwcc7 306 4 property property NN cord-287123-ldkuwcc7 306 5 of of IN cord-287123-ldkuwcc7 306 6 F1Pal16 F1Pal16 NNP cord-287123-ldkuwcc7 306 7 was be VBD cord-287123-ldkuwcc7 306 8 confirmed confirm VBN cord-287123-ldkuwcc7 306 9 by by IN cord-287123-ldkuwcc7 306 10 selective selective JJ cord-287123-ldkuwcc7 306 11 inhibition inhibition NN cord-287123-ldkuwcc7 306 12 in in IN cord-287123-ldkuwcc7 306 13 the the DT cord-287123-ldkuwcc7 306 14 binding binding NN cord-287123-ldkuwcc7 306 15 of of IN cord-287123-ldkuwcc7 306 16 a a DT cord-287123-ldkuwcc7 306 17 conventional conventional JJ cord-287123-ldkuwcc7 306 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 306 19 agonist agonist NN cord-287123-ldkuwcc7 306 20 ( ( -LRB- cord-287123-ldkuwcc7 306 21 Cy5-WKYMVM Cy5-WKYMVM NNP cord-287123-ldkuwcc7 306 22 ) ) -RRB- cord-287123-ldkuwcc7 306 23 . . . cord-287123-ldkuwcc7 307 1 This this DT cord-287123-ldkuwcc7 307 2 is be VBZ cord-287123-ldkuwcc7 307 3 not not RB cord-287123-ldkuwcc7 307 4 the the DT cord-287123-ldkuwcc7 307 5 first first JJ cord-287123-ldkuwcc7 307 6 pepducin pepducin NNS cord-287123-ldkuwcc7 307 7 designed design VBN cord-287123-ldkuwcc7 307 8 to to TO cord-287123-ldkuwcc7 307 9 target target VB cord-287123-ldkuwcc7 307 10 another another DT cord-287123-ldkuwcc7 307 11 GPCR GPCR NNP cord-287123-ldkuwcc7 307 12 but but CC cord-287123-ldkuwcc7 307 13 instead instead RB cord-287123-ldkuwcc7 307 14 was be VBD cord-287123-ldkuwcc7 307 15 found find VBN cord-287123-ldkuwcc7 307 16 to to TO cord-287123-ldkuwcc7 307 17 hijack hijack VB cord-287123-ldkuwcc7 307 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 307 19 ; ; : cord-287123-ldkuwcc7 307 20 however however RB cord-287123-ldkuwcc7 307 21 it -PRON- PRP cord-287123-ldkuwcc7 307 22 is be VBZ cord-287123-ldkuwcc7 307 23 the the DT cord-287123-ldkuwcc7 307 24 first first JJ cord-287123-ldkuwcc7 307 25 FPR FPR NNP cord-287123-ldkuwcc7 307 26 pepducin pepducin NNS cord-287123-ldkuwcc7 307 27 with with IN cord-287123-ldkuwcc7 307 28 antagonistic antagonistic JJ cord-287123-ldkuwcc7 307 29 activity activity NN cord-287123-ldkuwcc7 307 30 . . . cord-287123-ldkuwcc7 308 1 Pam-(Lys Pam-(Lys NNP cord-287123-ldkuwcc7 308 2 - - HYPH cord-287123-ldkuwcc7 308 3 βNSpe)6-NH2 βNSpe)6-NH2 NNP cord-287123-ldkuwcc7 308 4 , , , cord-287123-ldkuwcc7 309 1 a a DT cord-287123-ldkuwcc7 309 2 lapidated lapidated JJ cord-287123-ldkuwcc7 309 3 α α NN cord-287123-ldkuwcc7 309 4 - - HYPH cord-287123-ldkuwcc7 309 5 peptide peptide NN cord-287123-ldkuwcc7 309 6 / / SYM cord-287123-ldkuwcc7 309 7 β β NN cord-287123-ldkuwcc7 309 8 - - HYPH cord-287123-ldkuwcc7 309 9 peptoid peptoid NNP cord-287123-ldkuwcc7 309 10 oligomers oligomer NNS cord-287123-ldkuwcc7 309 11 was be VBD cord-287123-ldkuwcc7 309 12 recently recently RB cord-287123-ldkuwcc7 309 13 found find VBN cord-287123-ldkuwcc7 309 14 to to TO cord-287123-ldkuwcc7 309 15 be be VB cord-287123-ldkuwcc7 309 16 a a DT cord-287123-ldkuwcc7 309 17 cross cross NN cord-287123-ldkuwcc7 309 18 - - JJ cord-287123-ldkuwcc7 309 19 species species JJ cord-287123-ldkuwcc7 309 20 antagonist antagonist NN cord-287123-ldkuwcc7 309 21 with with IN cord-287123-ldkuwcc7 309 22 selectivity selectivity NN cord-287123-ldkuwcc7 309 23 for for IN cord-287123-ldkuwcc7 309 24 FPR2 FPR2 NNP cord-287123-ldkuwcc7 309 25 and and CC cord-287123-ldkuwcc7 309 26 mFpr2 mFpr2 VBD cord-287123-ldkuwcc7 309 27 [ [ -LRB- cord-287123-ldkuwcc7 309 28 92 92 CD cord-287123-ldkuwcc7 309 29 , , , cord-287123-ldkuwcc7 309 30 93 93 CD cord-287123-ldkuwcc7 309 31 ] ] -RRB- cord-287123-ldkuwcc7 309 32 . . . cord-287123-ldkuwcc7 310 1 Pam-(Lys Pam-(Lys NNP cord-287123-ldkuwcc7 310 2 - - HYPH cord-287123-ldkuwcc7 310 3 βNSpe)6-NH βNSpe)6-NH NNP cord-287123-ldkuwcc7 310 4 2 2 CD cord-287123-ldkuwcc7 310 5 belongs belong VBZ cord-287123-ldkuwcc7 310 6 to to IN cord-287123-ldkuwcc7 310 7 a a DT cord-287123-ldkuwcc7 310 8 group group NN cord-287123-ldkuwcc7 310 9 of of IN cord-287123-ldkuwcc7 310 10 immunomodulatory immunomodulatory NNP cord-287123-ldkuwcc7 310 11 host host NNP cord-287123-ldkuwcc7 310 12 defense defense NN cord-287123-ldkuwcc7 310 13 peptides peptide NNS cord-287123-ldkuwcc7 310 14 ( ( -LRB- cord-287123-ldkuwcc7 310 15 HDPs HDPs NNP cord-287123-ldkuwcc7 310 16 ) ) -RRB- cord-287123-ldkuwcc7 310 17 , , , cord-287123-ldkuwcc7 310 18 however however RB cord-287123-ldkuwcc7 310 19 , , , cord-287123-ldkuwcc7 310 20 unlike unlike IN cord-287123-ldkuwcc7 310 21 most most JJS cord-287123-ldkuwcc7 310 22 HDPs HDPs NNPS cord-287123-ldkuwcc7 310 23 , , , cord-287123-ldkuwcc7 310 24 this this DT cord-287123-ldkuwcc7 310 25 synthetic synthetic JJ cord-287123-ldkuwcc7 310 26 HDP HDP NNP cord-287123-ldkuwcc7 310 27 mimic mimic VBP cord-287123-ldkuwcc7 310 28 is be VBZ cord-287123-ldkuwcc7 310 29 resistant resistant JJ cord-287123-ldkuwcc7 310 30 to to IN cord-287123-ldkuwcc7 310 31 proteolysis proteolysis NN cord-287123-ldkuwcc7 310 32 . . . cord-287123-ldkuwcc7 311 1 It -PRON- PRP cord-287123-ldkuwcc7 311 2 was be VBD cord-287123-ldkuwcc7 311 3 revealed reveal VBN cord-287123-ldkuwcc7 311 4 that that IN cord-287123-ldkuwcc7 311 5 both both CC cord-287123-ldkuwcc7 311 6 the the DT cord-287123-ldkuwcc7 311 7 lipid lipid NN cord-287123-ldkuwcc7 311 8 and and CC cord-287123-ldkuwcc7 311 9 peptidomimetic peptidomimetic JJ cord-287123-ldkuwcc7 311 10 portions portion NNS cord-287123-ldkuwcc7 311 11 are be VBP cord-287123-ldkuwcc7 311 12 important important JJ cord-287123-ldkuwcc7 311 13 for for IN cord-287123-ldkuwcc7 311 14 its -PRON- PRP$ cord-287123-ldkuwcc7 311 15 immunomodulatory immunomodulatory JJ cord-287123-ldkuwcc7 311 16 function function NN cord-287123-ldkuwcc7 311 17 . . . cord-287123-ldkuwcc7 312 1 Pam-(Lys Pam-(Lys NNP cord-287123-ldkuwcc7 312 2 - - HYPH cord-287123-ldkuwcc7 312 3 βNSpe)6-NH βNSpe)6-NH NNP cord-287123-ldkuwcc7 312 4 2 2 CD cord-287123-ldkuwcc7 312 5 can can MD cord-287123-ldkuwcc7 312 6 directly directly RB cord-287123-ldkuwcc7 312 7 bind bind VB cord-287123-ldkuwcc7 312 8 to to IN cord-287123-ldkuwcc7 312 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 312 10 and and CC cord-287123-ldkuwcc7 312 11 prevent prevent VB cord-287123-ldkuwcc7 312 12 the the DT cord-287123-ldkuwcc7 312 13 binding binding NN cord-287123-ldkuwcc7 312 14 of of IN cord-287123-ldkuwcc7 312 15 fluorescently fluorescently RB cord-287123-ldkuwcc7 312 16 labeled label VBN cord-287123-ldkuwcc7 312 17 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 312 18 agonist agonist NN cord-287123-ldkuwcc7 312 19 ( ( -LRB- cord-287123-ldkuwcc7 312 20 Cy5-WKYMWM cy5-wkymwm NN cord-287123-ldkuwcc7 312 21 ) ) -RRB- cord-287123-ldkuwcc7 312 22 but but CC cord-287123-ldkuwcc7 312 23 not not RB cord-287123-ldkuwcc7 312 24 the the DT cord-287123-ldkuwcc7 312 25 FPR1-specific FPR1-specific NNP cord-287123-ldkuwcc7 312 26 agonist agonist NN cord-287123-ldkuwcc7 312 27 ( ( -LRB- cord-287123-ldkuwcc7 312 28 FITC FITC NNP cord-287123-ldkuwcc7 312 29 - - HYPH cord-287123-ldkuwcc7 312 30 fNLFNYK fNLFNYK NNP cord-287123-ldkuwcc7 312 31 ) ) -RRB- cord-287123-ldkuwcc7 312 32 [ [ -LRB- cord-287123-ldkuwcc7 312 33 92 92 CD cord-287123-ldkuwcc7 312 34 ] ] -RRB- cord-287123-ldkuwcc7 312 35 . . . cord-287123-ldkuwcc7 313 1 The the DT cord-287123-ldkuwcc7 313 2 inhibitory inhibitory JJ cord-287123-ldkuwcc7 313 3 potency potency NN cord-287123-ldkuwcc7 313 4 of of IN cord-287123-ldkuwcc7 313 5 Pam-(Lys Pam-(Lys NNP cord-287123-ldkuwcc7 313 6 - - HYPH cord-287123-ldkuwcc7 313 7 βNSpe)6-NH βNSpe)6-NH NNP cord-287123-ldkuwcc7 313 8 2 2 CD cord-287123-ldkuwcc7 313 9 is be VBZ cord-287123-ldkuwcc7 313 10 close close JJ cord-287123-ldkuwcc7 313 11 to to IN cord-287123-ldkuwcc7 313 12 that that DT cord-287123-ldkuwcc7 313 13 of of IN cord-287123-ldkuwcc7 313 14 PBP10 PBP10 NNP cord-287123-ldkuwcc7 313 15 . . . cord-287123-ldkuwcc7 314 1 Both both DT cord-287123-ldkuwcc7 314 2 FPR2 FPR2 NNP cord-287123-ldkuwcc7 314 3 antagonists antagonist NNS cord-287123-ldkuwcc7 314 4 are be VBP cord-287123-ldkuwcc7 314 5 membrane membrane NN cord-287123-ldkuwcc7 314 6 permeable permeable JJ cord-287123-ldkuwcc7 314 7 and and CC cord-287123-ldkuwcc7 314 8 display display VB cord-287123-ldkuwcc7 314 9 a a DT cord-287123-ldkuwcc7 314 10 reversible reversible JJ cord-287123-ldkuwcc7 314 11 inhibition inhibition NN cord-287123-ldkuwcc7 314 12 pattern pattern NN cord-287123-ldkuwcc7 314 13 [ [ -LRB- cord-287123-ldkuwcc7 314 14 92 92 CD cord-287123-ldkuwcc7 314 15 ] ] -RRB- cord-287123-ldkuwcc7 314 16 . . . cord-287123-ldkuwcc7 315 1 Despite despite IN cord-287123-ldkuwcc7 315 2 the the DT cord-287123-ldkuwcc7 315 3 similarity similarity NN cord-287123-ldkuwcc7 315 4 , , , cord-287123-ldkuwcc7 315 5 their -PRON- PRP$ cord-287123-ldkuwcc7 315 6 action action NN cord-287123-ldkuwcc7 315 7 mechanisms mechanism NNS cord-287123-ldkuwcc7 315 8 appear appear VBP cord-287123-ldkuwcc7 315 9 divergent divergent JJ cord-287123-ldkuwcc7 315 10 , , , cord-287123-ldkuwcc7 315 11 because because IN cord-287123-ldkuwcc7 315 12 the the DT cord-287123-ldkuwcc7 315 13 rhodamine rhodamine NN cord-287123-ldkuwcc7 315 14 group group NN cord-287123-ldkuwcc7 315 15 in in IN cord-287123-ldkuwcc7 315 16 PBP10 PBP10 NNP cord-287123-ldkuwcc7 315 17 can can MD cord-287123-ldkuwcc7 315 18 not not RB cord-287123-ldkuwcc7 315 19 be be VB cord-287123-ldkuwcc7 315 20 exchanged exchange VBN cord-287123-ldkuwcc7 315 21 for for IN cord-287123-ldkuwcc7 315 22 hexadecanoic hexadecanoic NN cord-287123-ldkuwcc7 315 23 acid acid NN cord-287123-ldkuwcc7 315 24 in in IN cord-287123-ldkuwcc7 315 25 the the DT cord-287123-ldkuwcc7 315 26 HDP HDP NNP cord-287123-ldkuwcc7 315 27 mimic mimic VBP cord-287123-ldkuwcc7 315 28 peptide peptide NN cord-287123-ldkuwcc7 315 29 [ [ -LRB- cord-287123-ldkuwcc7 315 30 90 90 CD cord-287123-ldkuwcc7 315 31 ] ] -RRB- cord-287123-ldkuwcc7 315 32 . . . cord-287123-ldkuwcc7 316 1 It -PRON- PRP cord-287123-ldkuwcc7 316 2 was be VBD cord-287123-ldkuwcc7 316 3 suggested suggest VBN cord-287123-ldkuwcc7 316 4 that that IN cord-287123-ldkuwcc7 316 5 Pam-(Lys Pam-(Lys NNP cord-287123-ldkuwcc7 316 6 - - HYPH cord-287123-ldkuwcc7 316 7 βNSpe)6-NH βnspe)6-nh $ cord-287123-ldkuwcc7 316 8 2 2 CD cord-287123-ldkuwcc7 316 9 and and CC cord-287123-ldkuwcc7 316 10 its -PRON- PRP$ cord-287123-ldkuwcc7 316 11 structural structural JJ cord-287123-ldkuwcc7 316 12 analogs analog NNS cord-287123-ldkuwcc7 316 13 are be VBP cord-287123-ldkuwcc7 316 14 allosteric allosteric JJ cord-287123-ldkuwcc7 316 15 modulators modulator NNS cord-287123-ldkuwcc7 316 16 of of IN cord-287123-ldkuwcc7 316 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 316 18 , , , cord-287123-ldkuwcc7 316 19 because because IN cord-287123-ldkuwcc7 316 20 they -PRON- PRP cord-287123-ldkuwcc7 316 21 can can MD cord-287123-ldkuwcc7 316 22 inhibit inhibit VB cord-287123-ldkuwcc7 316 23 neutrophil neutrophil NN cord-287123-ldkuwcc7 316 24 responses response NNS cord-287123-ldkuwcc7 316 25 induced induce VBN cord-287123-ldkuwcc7 316 26 by by IN cord-287123-ldkuwcc7 316 27 the the DT cord-287123-ldkuwcc7 316 28 FPR2 FPR2 NNP cord-287123-ldkuwcc7 316 29 pepducin pepducin NNS cord-287123-ldkuwcc7 316 30 F2Pal10 F2Pal10 NNP cord-287123-ldkuwcc7 316 31 , , , cord-287123-ldkuwcc7 316 32 which which WDT cord-287123-ldkuwcc7 316 33 is be VBZ cord-287123-ldkuwcc7 316 34 assumed assume VBN cord-287123-ldkuwcc7 316 35 to to TO cord-287123-ldkuwcc7 316 36 act act VB cord-287123-ldkuwcc7 316 37 in in IN cord-287123-ldkuwcc7 316 38 a a DT cord-287123-ldkuwcc7 316 39 different different JJ cord-287123-ldkuwcc7 316 40 way way NN cord-287123-ldkuwcc7 316 41 from from IN cord-287123-ldkuwcc7 316 42 conventional conventional JJ cord-287123-ldkuwcc7 316 43 FPR2 FPR2 NNP cord-287123-ldkuwcc7 316 44 agonists agonist NNS cord-287123-ldkuwcc7 316 45 by by IN cord-287123-ldkuwcc7 316 46 anchoring anchor VBG cord-287123-ldkuwcc7 316 47 to to IN cord-287123-ldkuwcc7 316 48 the the DT cord-287123-ldkuwcc7 316 49 intracellular intracellular JJ cord-287123-ldkuwcc7 316 50 loop loop NN cord-287123-ldkuwcc7 316 51 of of IN cord-287123-ldkuwcc7 316 52 the the DT cord-287123-ldkuwcc7 316 53 receptor receptor NN cord-287123-ldkuwcc7 316 54 [ [ -LRB- cord-287123-ldkuwcc7 316 55 73 73 CD cord-287123-ldkuwcc7 316 56 ] ] -RRB- cord-287123-ldkuwcc7 316 57 . . . cord-287123-ldkuwcc7 317 1 However however RB cord-287123-ldkuwcc7 317 2 , , , cord-287123-ldkuwcc7 317 3 like like IN cord-287123-ldkuwcc7 317 4 other other JJ cord-287123-ldkuwcc7 317 5 FPR2 FPR2 NNP cord-287123-ldkuwcc7 317 6 antagonists antagonist NNS cord-287123-ldkuwcc7 317 7 such such JJ cord-287123-ldkuwcc7 317 8 as as IN cord-287123-ldkuwcc7 317 9 WRW WRW NNP cord-287123-ldkuwcc7 317 10 4 4 CD cord-287123-ldkuwcc7 317 11 , , , cord-287123-ldkuwcc7 317 12 PBP10 PBP10 NNP cord-287123-ldkuwcc7 317 13 and and CC cord-287123-ldkuwcc7 317 14 FLIPr FLIPr NNS cord-287123-ldkuwcc7 317 15 were be VBD cord-287123-ldkuwcc7 317 16 also also RB cord-287123-ldkuwcc7 317 17 found find VBN cord-287123-ldkuwcc7 317 18 to to TO cord-287123-ldkuwcc7 317 19 inhibit inhibit VB cord-287123-ldkuwcc7 317 20 F2Pal10 F2Pal10 NNP cord-287123-ldkuwcc7 317 21 at at IN cord-287123-ldkuwcc7 317 22 FPR2 FPR2 NNP cord-287123-ldkuwcc7 317 23 , , , cord-287123-ldkuwcc7 317 24 an an DT cord-287123-ldkuwcc7 317 25 assumption assumption NN cord-287123-ldkuwcc7 317 26 requiring require VBG cord-287123-ldkuwcc7 317 27 further further JJ cord-287123-ldkuwcc7 317 28 verification verification NN cord-287123-ldkuwcc7 317 29 . . . cord-287123-ldkuwcc7 318 1 As as IN cord-287123-ldkuwcc7 318 2 FPRs fpr NNS cord-287123-ldkuwcc7 318 3 are be VBP cord-287123-ldkuwcc7 318 4 potential potential JJ cord-287123-ldkuwcc7 318 5 drug drug NN cord-287123-ldkuwcc7 318 6 targets target NNS cord-287123-ldkuwcc7 318 7 , , , cord-287123-ldkuwcc7 318 8 the the DT cord-287123-ldkuwcc7 318 9 search search NN cord-287123-ldkuwcc7 318 10 for for IN cord-287123-ldkuwcc7 318 11 novel novel JJ cord-287123-ldkuwcc7 318 12 FPR FPR NNP cord-287123-ldkuwcc7 318 13 antagonists antagonist NNS cord-287123-ldkuwcc7 318 14 / / SYM cord-287123-ldkuwcc7 318 15 inhibitors inhibitor NNS cord-287123-ldkuwcc7 318 16 with with IN cord-287123-ldkuwcc7 318 17 high high JJ cord-287123-ldkuwcc7 318 18 affinity affinity NN cord-287123-ldkuwcc7 318 19 and and CC cord-287123-ldkuwcc7 318 20 selectivity selectivity NN cord-287123-ldkuwcc7 318 21 remains remain VBZ cord-287123-ldkuwcc7 318 22 one one CD cord-287123-ldkuwcc7 318 23 of of IN cord-287123-ldkuwcc7 318 24 the the DT cord-287123-ldkuwcc7 318 25 fundamental fundamental JJ cord-287123-ldkuwcc7 318 26 aims aim NNS cord-287123-ldkuwcc7 318 27 of of IN cord-287123-ldkuwcc7 318 28 biomedical biomedical JJ cord-287123-ldkuwcc7 318 29 research research NN cord-287123-ldkuwcc7 318 30 in in IN cord-287123-ldkuwcc7 318 31 this this DT cord-287123-ldkuwcc7 318 32 field field NN cord-287123-ldkuwcc7 318 33 . . . cord-287123-ldkuwcc7 319 1 The the DT cord-287123-ldkuwcc7 319 2 first first JJ cord-287123-ldkuwcc7 319 3 reported report VBD cord-287123-ldkuwcc7 319 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 319 5 competitive competitive JJ cord-287123-ldkuwcc7 319 6 antagonist antagonist NN cord-287123-ldkuwcc7 319 7 is be VBZ cord-287123-ldkuwcc7 319 8 a a DT cord-287123-ldkuwcc7 319 9 non non JJ cord-287123-ldkuwcc7 319 10 - - JJ cord-287123-ldkuwcc7 319 11 steroidal steroidal JJ cord-287123-ldkuwcc7 319 12 anti anti JJ cord-287123-ldkuwcc7 319 13 - - JJ cord-287123-ldkuwcc7 319 14 inflammatory inflammatory JJ cord-287123-ldkuwcc7 319 15 drug drug NN cord-287123-ldkuwcc7 319 16 ( ( -LRB- cord-287123-ldkuwcc7 319 17 NSAID NSAID NNP cord-287123-ldkuwcc7 319 18 ) ) -RRB- cord-287123-ldkuwcc7 319 19 , , , cord-287123-ldkuwcc7 319 20 Sulfinpyrazone Sulfinpyrazone NNP cord-287123-ldkuwcc7 319 21 and and CC cord-287123-ldkuwcc7 319 22 its -PRON- PRP$ cord-287123-ldkuwcc7 319 23 derivative derivative JJ cord-287123-ldkuwcc7 319 24 1,2-diphenyl-4-(3-(1-naphthyl)-propyl)-3,5-pyrazolidinedione 1,2-diphenyl-4-(3-(1-naphthyl)-propyl)-3,5-pyrazolidinedione CD cord-287123-ldkuwcc7 319 25 ( ( -LRB- cord-287123-ldkuwcc7 319 26 DNP DNP NNP cord-287123-ldkuwcc7 319 27 ) ) -RRB- cord-287123-ldkuwcc7 319 28 [ [ -LRB- cord-287123-ldkuwcc7 319 29 195 195 CD cord-287123-ldkuwcc7 319 30 , , , cord-287123-ldkuwcc7 319 31 196 196 CD cord-287123-ldkuwcc7 319 32 ] ] -RRB- cord-287123-ldkuwcc7 319 33 . . . cord-287123-ldkuwcc7 320 1 However however RB cord-287123-ldkuwcc7 320 2 , , , cord-287123-ldkuwcc7 320 3 Sulfinpyrazone Sulfinpyrazone NNP cord-287123-ldkuwcc7 320 4 is be VBZ cord-287123-ldkuwcc7 320 5 a a DT cord-287123-ldkuwcc7 320 6 low low JJ cord-287123-ldkuwcc7 320 7 affinity affinity NN cord-287123-ldkuwcc7 320 8 ( ( -LRB- cord-287123-ldkuwcc7 320 9 K K NNP cord-287123-ldkuwcc7 320 10 i i NN cord-287123-ldkuwcc7 320 11 = = NN cord-287123-ldkuwcc7 320 12 14 14 CD cord-287123-ldkuwcc7 320 13 µM µm CD cord-287123-ldkuwcc7 320 14 ) ) -RRB- cord-287123-ldkuwcc7 320 15 and and CC cord-287123-ldkuwcc7 320 16 non non JJ cord-287123-ldkuwcc7 320 17 - - JJ cord-287123-ldkuwcc7 320 18 specific specific JJ cord-287123-ldkuwcc7 320 19 ligand ligand NN cord-287123-ldkuwcc7 320 20 at at IN cord-287123-ldkuwcc7 320 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 320 22 [ [ -LRB- cord-287123-ldkuwcc7 320 23 197 197 CD cord-287123-ldkuwcc7 320 24 , , , cord-287123-ldkuwcc7 320 25 198 198 CD cord-287123-ldkuwcc7 320 26 ] ] -RRB- cord-287123-ldkuwcc7 320 27 . . . cord-287123-ldkuwcc7 321 1 In in IN cord-287123-ldkuwcc7 321 2 recent recent JJ cord-287123-ldkuwcc7 321 3 years year NNS cord-287123-ldkuwcc7 321 4 , , , cord-287123-ldkuwcc7 321 5 numerous numerous JJ cord-287123-ldkuwcc7 321 6 small small JJ cord-287123-ldkuwcc7 321 7 molecule molecule NN cord-287123-ldkuwcc7 321 8 compounds compound NNS cord-287123-ldkuwcc7 321 9 have have VBP cord-287123-ldkuwcc7 321 10 been be VBN cord-287123-ldkuwcc7 321 11 discovered discover VBN cord-287123-ldkuwcc7 321 12 to to TO cord-287123-ldkuwcc7 321 13 have have VB cord-287123-ldkuwcc7 321 14 antagonistic antagonistic JJ cord-287123-ldkuwcc7 321 15 / / SYM cord-287123-ldkuwcc7 321 16 inhibitory inhibitory JJ cord-287123-ldkuwcc7 321 17 effects effect NNS cord-287123-ldkuwcc7 321 18 using use VBG cord-287123-ldkuwcc7 321 19 HTS HTS NNP cord-287123-ldkuwcc7 321 20 of of IN cord-287123-ldkuwcc7 321 21 either either DT cord-287123-ldkuwcc7 321 22 mixture mixture NN cord-287123-ldkuwcc7 321 23 - - HYPH cord-287123-ldkuwcc7 321 24 based base VBN cord-287123-ldkuwcc7 321 25 combinatorial combinatorial JJ cord-287123-ldkuwcc7 321 26 libraries library NNS cord-287123-ldkuwcc7 321 27 or or CC cord-287123-ldkuwcc7 321 28 natural natural JJ cord-287123-ldkuwcc7 321 29 product product NN cord-287123-ldkuwcc7 321 30 - - HYPH cord-287123-ldkuwcc7 321 31 based base VBN cord-287123-ldkuwcc7 321 32 drug drug NN cord-287123-ldkuwcc7 321 33 designs design NNS cord-287123-ldkuwcc7 321 34 combined combine VBN cord-287123-ldkuwcc7 321 35 with with IN cord-287123-ldkuwcc7 321 36 SAR SAR NNP cord-287123-ldkuwcc7 321 37 analysis analysis NN cord-287123-ldkuwcc7 321 38 and and CC cord-287123-ldkuwcc7 321 39 computational computational JJ cord-287123-ldkuwcc7 321 40 modeling modeling NN cord-287123-ldkuwcc7 321 41 . . . cord-287123-ldkuwcc7 322 1 Although although IN cord-287123-ldkuwcc7 322 2 there there EX cord-287123-ldkuwcc7 322 3 are be VBP cord-287123-ldkuwcc7 322 4 hundreds hundred NNS cord-287123-ldkuwcc7 322 5 of of IN cord-287123-ldkuwcc7 322 6 antagonistic antagonistic JJ cord-287123-ldkuwcc7 322 7 / / SYM cord-287123-ldkuwcc7 322 8 inhibitory inhibitory JJ cord-287123-ldkuwcc7 322 9 small small JJ cord-287123-ldkuwcc7 322 10 molecules molecule NNS cord-287123-ldkuwcc7 322 11 in in IN cord-287123-ldkuwcc7 322 12 published publish VBN cord-287123-ldkuwcc7 322 13 reports report NNS cord-287123-ldkuwcc7 322 14 , , , cord-287123-ldkuwcc7 322 15 the the DT cord-287123-ldkuwcc7 322 16 fully fully RB cord-287123-ldkuwcc7 322 17 characterized characterize VBN cord-287123-ldkuwcc7 322 18 chemical chemical JJ cord-287123-ldkuwcc7 322 19 antagonists antagonist NNS cord-287123-ldkuwcc7 322 20 with with IN cord-287123-ldkuwcc7 322 21 high high JJ cord-287123-ldkuwcc7 322 22 potency potency NN cord-287123-ldkuwcc7 322 23 ( ( -LRB- cord-287123-ldkuwcc7 322 24 K K NNP cord-287123-ldkuwcc7 322 25 i i XX cord-287123-ldkuwcc7 323 1 < < XX cord-287123-ldkuwcc7 323 2 10 10 CD cord-287123-ldkuwcc7 323 3 µM µM NNP cord-287123-ldkuwcc7 323 4 ) ) -RRB- cord-287123-ldkuwcc7 323 5 are be VBP cord-287123-ldkuwcc7 323 6 no no DT cord-287123-ldkuwcc7 323 7 more more JJR cord-287123-ldkuwcc7 323 8 than than IN cord-287123-ldkuwcc7 323 9 10 10 CD cord-287123-ldkuwcc7 323 10 compounds compound NNS cord-287123-ldkuwcc7 323 11 after after IN cord-287123-ldkuwcc7 323 12 excluding exclude VBG cord-287123-ldkuwcc7 323 13 those those DT cord-287123-ldkuwcc7 323 14 without without IN cord-287123-ldkuwcc7 323 15 binding bind VBG cord-287123-ldkuwcc7 323 16 analysis analysis NN cord-287123-ldkuwcc7 323 17 and/or and/or CC cord-287123-ldkuwcc7 323 18 agonistic agonistic JJ cord-287123-ldkuwcc7 323 19 activity activity NN cord-287123-ldkuwcc7 323 20 assays assay NNS cord-287123-ldkuwcc7 323 21 . . . cord-287123-ldkuwcc7 324 1 The the DT cord-287123-ldkuwcc7 324 2 4H 4h CD cord-287123-ldkuwcc7 324 3 - - HYPH cord-287123-ldkuwcc7 324 4 chromone chromone NN cord-287123-ldkuwcc7 324 5 compound compound NN cord-287123-ldkuwcc7 324 6 ( ( -LRB- cord-287123-ldkuwcc7 324 7 6-hexyl-2-methyl-3-(1-methyl-1H 6-hexyl-2-methyl-3-(1-methyl-1h CD cord-287123-ldkuwcc7 324 8 - - HYPH cord-287123-ldkuwcc7 324 9 benzimidazol-2-yl)-4-oxo-4Hchromen-7-yl benzimidazol-2-yl)-4-oxo-4Hchromen-7-yl NNP cord-287123-ldkuwcc7 324 10 acetate acetate NN cord-287123-ldkuwcc7 324 11 ) ) -RRB- cord-287123-ldkuwcc7 324 12 was be VBD cord-287123-ldkuwcc7 324 13 identified identify VBN cord-287123-ldkuwcc7 324 14 as as IN cord-287123-ldkuwcc7 324 15 the the DT cord-287123-ldkuwcc7 324 16 most most RBS cord-287123-ldkuwcc7 324 17 potent potent JJ cord-287123-ldkuwcc7 324 18 FPR1 FPR1 NNP cord-287123-ldkuwcc7 324 19 antagonist antagonist NN cord-287123-ldkuwcc7 324 20 ( ( -LRB- cord-287123-ldkuwcc7 324 21 K K NNP cord-287123-ldkuwcc7 324 22 i~1 i~1 NNP cord-287123-ldkuwcc7 324 23 00 00 NFP cord-287123-ldkuwcc7 324 24 nM nm NN cord-287123-ldkuwcc7 324 25 ) ) -RRB- cord-287123-ldkuwcc7 324 26 among among IN cord-287123-ldkuwcc7 324 27 the the DT cord-287123-ldkuwcc7 324 28 related related JJ cord-287123-ldkuwcc7 324 29 synthetic synthetic JJ cord-287123-ldkuwcc7 324 30 and and CC cord-287123-ldkuwcc7 324 31 natural natural JJ cord-287123-ldkuwcc7 324 32 isoflavones isoflavone NNS cord-287123-ldkuwcc7 324 33 . . . cord-287123-ldkuwcc7 325 1 This this DT cord-287123-ldkuwcc7 325 2 isoflavone isoflavone NN cord-287123-ldkuwcc7 325 3 and and CC cord-287123-ldkuwcc7 325 4 analogs analog NNS cord-287123-ldkuwcc7 325 5 were be VBD cord-287123-ldkuwcc7 325 6 found find VBN cord-287123-ldkuwcc7 325 7 to to TO cord-287123-ldkuwcc7 325 8 suppress suppress VB cord-287123-ldkuwcc7 325 9 agonist agonist NN cord-287123-ldkuwcc7 325 10 - - HYPH cord-287123-ldkuwcc7 325 11 stimulated stimulate VBN cord-287123-ldkuwcc7 325 12 calcium calcium NN cord-287123-ldkuwcc7 325 13 flux flux NN cord-287123-ldkuwcc7 325 14 and and CC cord-287123-ldkuwcc7 325 15 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 325 16 of of IN cord-287123-ldkuwcc7 325 17 neutrophils neutrophil NNS cord-287123-ldkuwcc7 325 18 with with IN cord-287123-ldkuwcc7 325 19 IC IC NNP cord-287123-ldkuwcc7 325 20 50 50 CD cord-287123-ldkuwcc7 325 21 values value NNS cord-287123-ldkuwcc7 325 22 of of IN cord-287123-ldkuwcc7 325 23 0.02~20 0.02~20 CD cord-287123-ldkuwcc7 325 24 µM µM . cord-287123-ldkuwcc7 326 1 [ [ -LRB- cord-287123-ldkuwcc7 326 2 94 94 CD cord-287123-ldkuwcc7 326 3 ] ] -RRB- cord-287123-ldkuwcc7 326 4 . . . cord-287123-ldkuwcc7 327 1 The the DT cord-287123-ldkuwcc7 327 2 competitive competitive JJ cord-287123-ldkuwcc7 327 3 analysis analysis NN cord-287123-ldkuwcc7 327 4 showed show VBD cord-287123-ldkuwcc7 327 5 that that IN cord-287123-ldkuwcc7 327 6 they -PRON- PRP cord-287123-ldkuwcc7 327 7 are be VBP cord-287123-ldkuwcc7 327 8 specific specific JJ cord-287123-ldkuwcc7 327 9 for for IN cord-287123-ldkuwcc7 327 10 FPR1 FPR1 NNP cord-287123-ldkuwcc7 327 11 and and CC cord-287123-ldkuwcc7 327 12 did do VBD cord-287123-ldkuwcc7 327 13 not not RB cord-287123-ldkuwcc7 327 14 inhibit inhibit VB cord-287123-ldkuwcc7 327 15 FPR2- fpr2- JJ cord-287123-ldkuwcc7 327 16 , , , cord-287123-ldkuwcc7 327 17 FPR3- fpr3- NN cord-287123-ldkuwcc7 327 18 , , , cord-287123-ldkuwcc7 327 19 CXCR1-or CXCR1-or NNP cord-287123-ldkuwcc7 327 20 murine murine JJ cord-287123-ldkuwcc7 327 21 mFpr1-dependent mFpr1-dependent NNP cord-287123-ldkuwcc7 327 22 responses response NNS cord-287123-ldkuwcc7 327 23 . . . cord-287123-ldkuwcc7 328 1 They -PRON- PRP cord-287123-ldkuwcc7 328 2 have have VBP cord-287123-ldkuwcc7 328 3 been be VBN cord-287123-ldkuwcc7 328 4 also also RB cord-287123-ldkuwcc7 328 5 shown show VBN cord-287123-ldkuwcc7 328 6 to to TO cord-287123-ldkuwcc7 328 7 be be VB cord-287123-ldkuwcc7 328 8 inactive inactive JJ cord-287123-ldkuwcc7 328 9 as as IN cord-287123-ldkuwcc7 328 10 direct direct JJ cord-287123-ldkuwcc7 328 11 agonists agonist NNS cord-287123-ldkuwcc7 328 12 of of IN cord-287123-ldkuwcc7 328 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 328 14 / / SYM cord-287123-ldkuwcc7 328 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 328 16 and and CC cord-287123-ldkuwcc7 328 17 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 328 18 [ [ -LRB- cord-287123-ldkuwcc7 328 19 94 94 CD cord-287123-ldkuwcc7 328 20 ] ] -RRB- cord-287123-ldkuwcc7 328 21 . . . cord-287123-ldkuwcc7 329 1 A a DT cord-287123-ldkuwcc7 329 2 hederagenin hederagenin NN cord-287123-ldkuwcc7 329 3 SMG-1 SMG-1 NNP cord-287123-ldkuwcc7 330 1 [ [ -LRB- cord-287123-ldkuwcc7 330 2 3-O-(3,4-Odi 3-o-(3,4-odi CD cord-287123-ldkuwcc7 330 3 - - HYPH cord-287123-ldkuwcc7 330 4 acetylα acetylα NNP cord-287123-ldkuwcc7 330 5 - - HYPH cord-287123-ldkuwcc7 330 6 L l NN cord-287123-ldkuwcc7 330 7 - - HYPH cord-287123-ldkuwcc7 330 8 arabinopyranoside)-(1 arabinopyranoside)-(1 NN cord-287123-ldkuwcc7 331 1 → → IN cord-287123-ldkuwcc7 331 2 3)-α 3)-α CD cord-287123-ldkuwcc7 331 3 - - HYPH cord-287123-ldkuwcc7 331 4 L l NN cord-287123-ldkuwcc7 331 5 - - HYPH cord-287123-ldkuwcc7 331 6 rhamnopyranosyl-(1 rhamnopyranosyl-(1 NNP cord-287123-ldkuwcc7 331 7 → → SYM cord-287123-ldkuwcc7 331 8 2)-α 2)-α CD cord-287123-ldkuwcc7 331 9 - - HYPH cord-287123-ldkuwcc7 331 10 L L NNP cord-287123-ldkuwcc7 331 11 - - HYPH cord-287123-ldkuwcc7 331 12 arabinopyranoside arabinopyranoside NNP cord-287123-ldkuwcc7 331 13 ] ] -RRB- cord-287123-ldkuwcc7 331 14 , , , cord-287123-ldkuwcc7 331 15 a a DT cord-287123-ldkuwcc7 331 16 saponin saponin NN cord-287123-ldkuwcc7 331 17 isolated isolate VBN cord-287123-ldkuwcc7 331 18 from from IN cord-287123-ldkuwcc7 331 19 Sapindus Sapindus NNP cord-287123-ldkuwcc7 331 20 mukorossi mukorossi NNP cord-287123-ldkuwcc7 331 21 , , , cord-287123-ldkuwcc7 331 22 was be VBD cord-287123-ldkuwcc7 331 23 reported report VBN cord-287123-ldkuwcc7 331 24 to to TO cord-287123-ldkuwcc7 331 25 block block VB cord-287123-ldkuwcc7 331 26 binding binding NN cord-287123-ldkuwcc7 331 27 of of IN cord-287123-ldkuwcc7 331 28 fluorescently fluorescently RB cord-287123-ldkuwcc7 331 29 labeled label VBN cord-287123-ldkuwcc7 331 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 331 31 ligand ligand NN cord-287123-ldkuwcc7 331 32 fNLFNYK fnlfnyk NN cord-287123-ldkuwcc7 332 1 ( ( -LRB- cord-287123-ldkuwcc7 332 2 K K NNP cord-287123-ldkuwcc7 332 3 i i PRP cord-287123-ldkuwcc7 333 1 < < XX cord-287123-ldkuwcc7 333 2 10 10 CD cord-287123-ldkuwcc7 333 3 µM µm CD cord-287123-ldkuwcc7 333 4 ) ) -RRB- cord-287123-ldkuwcc7 334 1 and and CC cord-287123-ldkuwcc7 334 2 inhibit inhibit VB cord-287123-ldkuwcc7 334 3 FPR1-mediated FPR1-mediated NNP cord-287123-ldkuwcc7 334 4 response response NN cord-287123-ldkuwcc7 334 5 in in IN cord-287123-ldkuwcc7 334 6 neutrophils neutrophil NNS cord-287123-ldkuwcc7 334 7 and and CC cord-287123-ldkuwcc7 334 8 FPR1-expressing FPR1-expressing NNP cord-287123-ldkuwcc7 334 9 HL-60 HL-60 NNP cord-287123-ldkuwcc7 334 10 cells cell NNS cord-287123-ldkuwcc7 334 11 [ [ -LRB- cord-287123-ldkuwcc7 334 12 199 199 CD cord-287123-ldkuwcc7 334 13 , , , cord-287123-ldkuwcc7 334 14 200 200 CD cord-287123-ldkuwcc7 334 15 ] ] -RRB- cord-287123-ldkuwcc7 334 16 . . . cord-287123-ldkuwcc7 335 1 It -PRON- PRP cord-287123-ldkuwcc7 335 2 has have VBZ cord-287123-ldkuwcc7 335 3 been be VBN cord-287123-ldkuwcc7 335 4 verified verify VBN cord-287123-ldkuwcc7 335 5 that that IN cord-287123-ldkuwcc7 335 6 SMG-1 SMG-1 NNP cord-287123-ldkuwcc7 335 7 has have VBZ cord-287123-ldkuwcc7 335 8 no no DT cord-287123-ldkuwcc7 335 9 direct direct JJ cord-287123-ldkuwcc7 335 10 agonist agonist NN cord-287123-ldkuwcc7 335 11 effects effect NNS cord-287123-ldkuwcc7 335 12 . . . cord-287123-ldkuwcc7 336 1 In in IN cord-287123-ldkuwcc7 336 2 another another DT cord-287123-ldkuwcc7 336 3 study study NN cord-287123-ldkuwcc7 336 4 , , , cord-287123-ldkuwcc7 336 5 a a DT cord-287123-ldkuwcc7 336 6 lignin lignin JJ cord-287123-ldkuwcc7 336 7 PP-6 PP-6 NNP cord-287123-ldkuwcc7 336 8 [ [ -LRB- cord-287123-ldkuwcc7 336 9 ( ( -LRB- cord-287123-ldkuwcc7 336 10 2R,3R)-2-(3 2r,3r)-2-(3 CD cord-287123-ldkuwcc7 336 11 , , , cord-287123-ldkuwcc7 336 12 4 4 CD cord-287123-ldkuwcc7 336 13 -dihydroxybenzyl)-3-(3 -dihydroxybenzyl)-3-(3 ADD cord-287123-ldkuwcc7 336 14 , , , cord-287123-ldkuwcc7 336 15 4"-dimethoxybenzyl 4"-dimethoxybenzyl CD cord-287123-ldkuwcc7 336 16 ) ) -RRB- cord-287123-ldkuwcc7 336 17 butyrolactone butyrolactone NN cord-287123-ldkuwcc7 336 18 ] ] -RRB- cord-287123-ldkuwcc7 336 19 , , , cord-287123-ldkuwcc7 336 20 isolated isolate VBN cord-287123-ldkuwcc7 336 21 from from IN cord-287123-ldkuwcc7 336 22 Piper Piper NNP cord-287123-ldkuwcc7 336 23 philippinum philippinum NNS cord-287123-ldkuwcc7 336 24 , , , cord-287123-ldkuwcc7 336 25 was be VBD cord-287123-ldkuwcc7 336 26 found find VBN cord-287123-ldkuwcc7 336 27 to to TO cord-287123-ldkuwcc7 336 28 inhibit inhibit VB cord-287123-ldkuwcc7 336 29 fMLF fmlf JJ cord-287123-ldkuwcc7 336 30 - - HYPH cord-287123-ldkuwcc7 336 31 induced induce VBN cord-287123-ldkuwcc7 336 32 neutrophil neutrophil NN cord-287123-ldkuwcc7 336 33 response response NN cord-287123-ldkuwcc7 336 34 and and CC cord-287123-ldkuwcc7 336 35 block block VB cord-287123-ldkuwcc7 336 36 FITC FITC NNP cord-287123-ldkuwcc7 336 37 - - HYPH cord-287123-ldkuwcc7 336 38 fMLF fmlf NN cord-287123-ldkuwcc7 336 39 binding binding NN cord-287123-ldkuwcc7 336 40 to to IN cord-287123-ldkuwcc7 336 41 neutrophil neutrophil NN cord-287123-ldkuwcc7 336 42 with with IN cord-287123-ldkuwcc7 336 43 a a DT cord-287123-ldkuwcc7 336 44 K k NN cord-287123-ldkuwcc7 337 1 i i PRP cord-287123-ldkuwcc7 338 1 of~1.5 of~1.5 CD cord-287123-ldkuwcc7 339 1 µM. µM. NNP cord-287123-ldkuwcc7 340 1 In in IN cord-287123-ldkuwcc7 340 2 the the DT cord-287123-ldkuwcc7 340 3 studies study NNS cord-287123-ldkuwcc7 340 4 of of IN cord-287123-ldkuwcc7 340 5 a a DT cord-287123-ldkuwcc7 340 6 pharmacophore pharmacophore JJ cord-287123-ldkuwcc7 340 7 model model NN cord-287123-ldkuwcc7 340 8 of of IN cord-287123-ldkuwcc7 340 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 340 10 antagonists antagonist NNS cord-287123-ldkuwcc7 340 11 and and CC cord-287123-ldkuwcc7 340 12 molecular molecular JJ cord-287123-ldkuwcc7 340 13 docking docking NN cord-287123-ldkuwcc7 340 14 , , , cord-287123-ldkuwcc7 340 15 PP-6 PP-6 NNP cord-287123-ldkuwcc7 340 16 displays display VBZ cord-287123-ldkuwcc7 340 17 impressive impressive JJ cord-287123-ldkuwcc7 340 18 properties property NNS cord-287123-ldkuwcc7 340 19 of of IN cord-287123-ldkuwcc7 340 20 FPR1 FPR1 NNP cord-287123-ldkuwcc7 340 21 antagonism antagonism NN cord-287123-ldkuwcc7 340 22 [ [ -LRB- cord-287123-ldkuwcc7 340 23 200 200 CD cord-287123-ldkuwcc7 340 24 ] ] -RRB- cord-287123-ldkuwcc7 340 25 . . . cord-287123-ldkuwcc7 341 1 However however RB cord-287123-ldkuwcc7 341 2 , , , cord-287123-ldkuwcc7 341 3 it -PRON- PRP cord-287123-ldkuwcc7 341 4 is be VBZ cord-287123-ldkuwcc7 341 5 difficult difficult JJ cord-287123-ldkuwcc7 341 6 to to TO cord-287123-ldkuwcc7 341 7 consider consider VB cord-287123-ldkuwcc7 341 8 PP-6 PP-6 NNP cord-287123-ldkuwcc7 341 9 a a DT cord-287123-ldkuwcc7 341 10 competitive competitive JJ cord-287123-ldkuwcc7 341 11 antagonist antagonist NN cord-287123-ldkuwcc7 341 12 for for IN cord-287123-ldkuwcc7 341 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 341 14 based base VBN cord-287123-ldkuwcc7 341 15 on on IN cord-287123-ldkuwcc7 341 16 the the DT cord-287123-ldkuwcc7 341 17 experimental experimental JJ cord-287123-ldkuwcc7 341 18 data datum NNS cord-287123-ldkuwcc7 341 19 because because IN cord-287123-ldkuwcc7 341 20 the the DT cord-287123-ldkuwcc7 341 21 antagonistic antagonistic JJ cord-287123-ldkuwcc7 341 22 effect effect NN cord-287123-ldkuwcc7 341 23 of of IN cord-287123-ldkuwcc7 341 24 PP-6 PP-6 NNP cord-287123-ldkuwcc7 341 25 appears appear VBZ cord-287123-ldkuwcc7 341 26 non non JJ cord-287123-ldkuwcc7 341 27 - - JJ cord-287123-ldkuwcc7 341 28 competitive competitive JJ cord-287123-ldkuwcc7 341 29 and and CC cord-287123-ldkuwcc7 341 30 reversible reversible JJ cord-287123-ldkuwcc7 341 31 [ [ -LRB- cord-287123-ldkuwcc7 341 32 201 201 CD cord-287123-ldkuwcc7 341 33 ] ] -RRB- cord-287123-ldkuwcc7 341 34 . . . cord-287123-ldkuwcc7 342 1 Further further JJ cord-287123-ldkuwcc7 342 2 studies study NNS cord-287123-ldkuwcc7 342 3 are be VBP cord-287123-ldkuwcc7 342 4 also also RB cord-287123-ldkuwcc7 342 5 necessary necessary JJ cord-287123-ldkuwcc7 342 6 to to TO cord-287123-ldkuwcc7 342 7 address address VB cord-287123-ldkuwcc7 342 8 the the DT cord-287123-ldkuwcc7 342 9 specificity specificity NN cord-287123-ldkuwcc7 342 10 of of IN cord-287123-ldkuwcc7 342 11 this this DT cord-287123-ldkuwcc7 342 12 lignin lignin NN cord-287123-ldkuwcc7 342 13 . . . cord-287123-ldkuwcc7 343 1 By by IN cord-287123-ldkuwcc7 343 2 screening screen VBG cord-287123-ldkuwcc7 343 3 combinatorial combinatorial JJ cord-287123-ldkuwcc7 343 4 compound compound NN cord-287123-ldkuwcc7 343 5 libraries library NNS cord-287123-ldkuwcc7 343 6 , , , cord-287123-ldkuwcc7 343 7 a a DT cord-287123-ldkuwcc7 343 8 pyrolidine pyrolidine JJ cord-287123-ldkuwcc7 343 9 bis bis NNP cord-287123-ldkuwcc7 343 10 - - HYPH cord-287123-ldkuwcc7 343 11 diketopiperazine diketopiperazine NN cord-287123-ldkuwcc7 343 12 - - HYPH cord-287123-ldkuwcc7 343 13 based base VBN cord-287123-ldkuwcc7 343 14 compound compound NN cord-287123-ldkuwcc7 343 15 1754 1754 CD cord-287123-ldkuwcc7 343 16 - - SYM cord-287123-ldkuwcc7 343 17 31 31 CD cord-287123-ldkuwcc7 343 18 was be VBD cord-287123-ldkuwcc7 343 19 recently recently RB cord-287123-ldkuwcc7 343 20 identified identify VBN cord-287123-ldkuwcc7 343 21 as as IN cord-287123-ldkuwcc7 343 22 the the DT cord-287123-ldkuwcc7 343 23 most most RBS cord-287123-ldkuwcc7 343 24 potent potent JJ cord-287123-ldkuwcc7 343 25 non non JJ cord-287123-ldkuwcc7 343 26 - - JJ cord-287123-ldkuwcc7 343 27 peptide peptide JJ cord-287123-ldkuwcc7 343 28 FPR2 FPR2 NNP cord-287123-ldkuwcc7 343 29 antagonist antagonist NN cord-287123-ldkuwcc7 343 30 with with IN cord-287123-ldkuwcc7 343 31 a a DT cord-287123-ldkuwcc7 343 32 K k NN cord-287123-ldkuwcc7 343 33 i i PRP cord-287123-ldkuwcc7 343 34 of of IN cord-287123-ldkuwcc7 343 35 1 1 CD cord-287123-ldkuwcc7 343 36 nM nm CD cord-287123-ldkuwcc7 343 37 and and CC cord-287123-ldkuwcc7 343 38 an an DT cord-287123-ldkuwcc7 343 39 IC IC NNP cord-287123-ldkuwcc7 343 40 50 50 CD cord-287123-ldkuwcc7 343 41 of of IN cord-287123-ldkuwcc7 343 42 81 81 CD cord-287123-ldkuwcc7 343 43 nM nm NN cord-287123-ldkuwcc7 343 44 in in IN cord-287123-ldkuwcc7 343 45 calcium calcium NN cord-287123-ldkuwcc7 343 46 mobilization mobilization NN cord-287123-ldkuwcc7 343 47 assays assay NNS cord-287123-ldkuwcc7 343 48 . . . cord-287123-ldkuwcc7 344 1 The the DT cord-287123-ldkuwcc7 344 2 compound compound NN cord-287123-ldkuwcc7 344 3 1754 1754 CD cord-287123-ldkuwcc7 344 4 - - SYM cord-287123-ldkuwcc7 344 5 31 31 CD cord-287123-ldkuwcc7 344 6 [ [ -LRB- cord-287123-ldkuwcc7 344 7 ( ( -LRB- cord-287123-ldkuwcc7 344 8 R)-4-(cyclohexylmethyl)-5-(4hydroxybenzyl)-1-((R)-1-((S)-2-(((S)-6-isopropyl-2,3-dioxopiperazin-1-yl)methyl)pyrrolidin-1-yl)-3-(naphthalen-2-yl)propan-2-yl)piperazine-2,3-dione R)-4-(cyclohexylmethyl)-5-(4hydroxybenzyl)-1-((R)-1-((S)-2-(((S)-6-isopropyl-2,3-dioxopiperazin-1-yl)methyl)pyrrolidin-1-yl)-3-(naphthalen-2-yl)propan-2-yl)piperazine-2,3-dione NNP cord-287123-ldkuwcc7 344 9 ] ] -RRB- cord-287123-ldkuwcc7 344 10 ) ) -RRB- cord-287123-ldkuwcc7 344 11 showed show VBD cord-287123-ldkuwcc7 344 12 no no DT cord-287123-ldkuwcc7 344 13 agonistic agonistic JJ cord-287123-ldkuwcc7 344 14 activity activity NN cord-287123-ldkuwcc7 344 15 at at IN cord-287123-ldkuwcc7 344 16 concentrations concentration NNS cord-287123-ldkuwcc7 344 17 up up IN cord-287123-ldkuwcc7 344 18 to to TO cord-287123-ldkuwcc7 344 19 12 12 CD cord-287123-ldkuwcc7 344 20 µM µm XX cord-287123-ldkuwcc7 344 21 [ [ -LRB- cord-287123-ldkuwcc7 344 22 84 84 CD cord-287123-ldkuwcc7 344 23 ] ] -RRB- cord-287123-ldkuwcc7 344 24 . . . cord-287123-ldkuwcc7 345 1 A a DT cord-287123-ldkuwcc7 345 2 quinazolinone quinazolinone NN cord-287123-ldkuwcc7 345 3 derivative derivative NN cord-287123-ldkuwcc7 345 4 was be VBD cord-287123-ldkuwcc7 345 5 previously previously RB cord-287123-ldkuwcc7 345 6 reported report VBN cord-287123-ldkuwcc7 345 7 to to TO cord-287123-ldkuwcc7 345 8 suppress suppress VB cord-287123-ldkuwcc7 345 9 FPR fpr NN cord-287123-ldkuwcc7 345 10 agonist agonist NN cord-287123-ldkuwcc7 345 11 - - HYPH cord-287123-ldkuwcc7 345 12 stimulated stimulate VBN cord-287123-ldkuwcc7 345 13 inflammatory inflammatory JJ cord-287123-ldkuwcc7 345 14 responses response NNS cord-287123-ldkuwcc7 345 15 in in IN cord-287123-ldkuwcc7 345 16 vitro vitro FW cord-287123-ldkuwcc7 345 17 and and CC cord-287123-ldkuwcc7 345 18 in in IN cord-287123-ldkuwcc7 345 19 an an DT cord-287123-ldkuwcc7 345 20 in in IN cord-287123-ldkuwcc7 345 21 vivo vivo NN cord-287123-ldkuwcc7 345 22 model model NN cord-287123-ldkuwcc7 345 23 [ [ -LRB- cord-287123-ldkuwcc7 345 24 96 96 CD cord-287123-ldkuwcc7 345 25 ] ] -RRB- cord-287123-ldkuwcc7 345 26 . . . cord-287123-ldkuwcc7 346 1 This this DT cord-287123-ldkuwcc7 346 2 Quin Quin NNP cord-287123-ldkuwcc7 346 3 - - HYPH cord-287123-ldkuwcc7 346 4 C1 C1 NNP cord-287123-ldkuwcc7 346 5 related relate VBN cord-287123-ldkuwcc7 346 6 quinazolinone quinazolinone NN cord-287123-ldkuwcc7 346 7 , , , cord-287123-ldkuwcc7 346 8 namely namely RB cord-287123-ldkuwcc7 346 9 Quin Quin NNP cord-287123-ldkuwcc7 346 10 - - HYPH cord-287123-ldkuwcc7 346 11 C7 C7 NNP cord-287123-ldkuwcc7 346 12 , , , cord-287123-ldkuwcc7 346 13 was be VBD cord-287123-ldkuwcc7 346 14 proven prove VBN cord-287123-ldkuwcc7 346 15 to to TO cord-287123-ldkuwcc7 346 16 have have VB cord-287123-ldkuwcc7 346 17 no no DT cord-287123-ldkuwcc7 346 18 agonist agonist NN cord-287123-ldkuwcc7 346 19 activity activity NN cord-287123-ldkuwcc7 346 20 . . . cord-287123-ldkuwcc7 347 1 It -PRON- PRP cord-287123-ldkuwcc7 347 2 could could MD cord-287123-ldkuwcc7 347 3 displace displace VB cord-287123-ldkuwcc7 347 4 [ [ -LRB- cord-287123-ldkuwcc7 347 5 125 125 CD cord-287123-ldkuwcc7 347 6 I]WKYMVm i]wkymvm NN cord-287123-ldkuwcc7 347 7 binding bind VBG cord-287123-ldkuwcc7 347 8 to to IN cord-287123-ldkuwcc7 347 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 347 10 with with IN cord-287123-ldkuwcc7 347 11 an an DT cord-287123-ldkuwcc7 347 12 estimated estimate VBN cord-287123-ldkuwcc7 347 13 K K NNP cord-287123-ldkuwcc7 347 14 i i NN cord-287123-ldkuwcc7 347 15 of of IN cord-287123-ldkuwcc7 347 16 6.7 6.7 CD cord-287123-ldkuwcc7 347 17 µM. µm. JJ cord-287123-ldkuwcc7 348 1 It -PRON- PRP cord-287123-ldkuwcc7 348 2 did do VBD cord-287123-ldkuwcc7 348 3 not not RB cord-287123-ldkuwcc7 348 4 inhibit inhibit VB cord-287123-ldkuwcc7 348 5 the the DT cord-287123-ldkuwcc7 348 6 binding binding NN cord-287123-ldkuwcc7 348 7 of of IN cord-287123-ldkuwcc7 348 8 [ [ -LRB- cord-287123-ldkuwcc7 348 9 3 3 CD cord-287123-ldkuwcc7 348 10 H]fMLF H]fMLF NNP cord-287123-ldkuwcc7 348 11 to to IN cord-287123-ldkuwcc7 348 12 FPR1 FPR1 NNP cord-287123-ldkuwcc7 348 13 at at IN cord-287123-ldkuwcc7 348 14 concentrations concentration NNS cord-287123-ldkuwcc7 348 15 up up IN cord-287123-ldkuwcc7 348 16 to to TO cord-287123-ldkuwcc7 348 17 100 100 CD cord-287123-ldkuwcc7 348 18 µM µM NNS cord-287123-ldkuwcc7 348 19 , , , cord-287123-ldkuwcc7 348 20 indicating indicate VBG cord-287123-ldkuwcc7 348 21 a a DT cord-287123-ldkuwcc7 348 22 high high JJ cord-287123-ldkuwcc7 348 23 preference preference NN cord-287123-ldkuwcc7 348 24 for for IN cord-287123-ldkuwcc7 348 25 FPR2 FPR2 NNP cord-287123-ldkuwcc7 348 26 over over IN cord-287123-ldkuwcc7 348 27 FPR1 FPR1 NNP cord-287123-ldkuwcc7 348 28 [ [ -LRB- cord-287123-ldkuwcc7 348 29 95 95 CD cord-287123-ldkuwcc7 348 30 ] ] -RRB- cord-287123-ldkuwcc7 348 31 . . . cord-287123-ldkuwcc7 349 1 Quin Quin NNP cord-287123-ldkuwcc7 349 2 - - HYPH cord-287123-ldkuwcc7 349 3 C7 C7 NNP cord-287123-ldkuwcc7 349 4 was be VBD cord-287123-ldkuwcc7 349 5 described describe VBN cord-287123-ldkuwcc7 349 6 as as IN cord-287123-ldkuwcc7 349 7 an an DT cord-287123-ldkuwcc7 349 8 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 349 9 antagonist antagonist NN cord-287123-ldkuwcc7 349 10 , , , cord-287123-ldkuwcc7 349 11 albeit albeit IN cord-287123-ldkuwcc7 349 12 its -PRON- PRP$ cord-287123-ldkuwcc7 349 13 activity activity NN cord-287123-ldkuwcc7 349 14 at at IN cord-287123-ldkuwcc7 349 15 other other JJ cord-287123-ldkuwcc7 349 16 inflammation inflammation NN cord-287123-ldkuwcc7 349 17 - - HYPH cord-287123-ldkuwcc7 349 18 related relate VBN cord-287123-ldkuwcc7 349 19 receptors receptor NNS cord-287123-ldkuwcc7 349 20 ( ( -LRB- cord-287123-ldkuwcc7 349 21 such such JJ cord-287123-ldkuwcc7 349 22 as as IN cord-287123-ldkuwcc7 349 23 C5aR C5aR NNP cord-287123-ldkuwcc7 349 24 and and CC cord-287123-ldkuwcc7 349 25 CXCR CXCR NNP cord-287123-ldkuwcc7 349 26 ) ) -RRB- cord-287123-ldkuwcc7 349 27 has have VBZ cord-287123-ldkuwcc7 349 28 not not RB cord-287123-ldkuwcc7 349 29 been be VBN cord-287123-ldkuwcc7 349 30 fully fully RB cord-287123-ldkuwcc7 349 31 examined examine VBN cord-287123-ldkuwcc7 349 32 . . . cord-287123-ldkuwcc7 350 1 Additional additional JJ cord-287123-ldkuwcc7 350 2 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 350 3 antagonists antagonist NNS cord-287123-ldkuwcc7 350 4 with with IN cord-287123-ldkuwcc7 350 5 an an DT cord-287123-ldkuwcc7 350 6 2-phenylimidazo[1,2-a]pyrimidine 2-phenylimidazo[1,2-a]pyrimidine CD cord-287123-ldkuwcc7 350 7 scaffold scaffold NN cord-287123-ldkuwcc7 350 8 were be VBD cord-287123-ldkuwcc7 350 9 discovered discover VBN cord-287123-ldkuwcc7 350 10 through through IN cord-287123-ldkuwcc7 350 11 the the DT cord-287123-ldkuwcc7 350 12 use use NN cord-287123-ldkuwcc7 350 13 of of IN cord-287123-ldkuwcc7 350 14 a a DT cord-287123-ldkuwcc7 350 15 high high JJ cord-287123-ldkuwcc7 350 16 - - HYPH cord-287123-ldkuwcc7 350 17 throughput throughput NN cord-287123-ldkuwcc7 350 18 HyperCyt HyperCyt NNP cord-287123-ldkuwcc7 350 19 flow flow NN cord-287123-ldkuwcc7 350 20 cytometric cytometric NN cord-287123-ldkuwcc7 350 21 platform platform NN cord-287123-ldkuwcc7 350 22 [ [ -LRB- cord-287123-ldkuwcc7 350 23 202 202 CD cord-287123-ldkuwcc7 350 24 ] ] -RRB- cord-287123-ldkuwcc7 350 25 [ [ -LRB- cord-287123-ldkuwcc7 350 26 203 203 CD cord-287123-ldkuwcc7 350 27 ] ] -RRB- cord-287123-ldkuwcc7 350 28 [ [ -LRB- cord-287123-ldkuwcc7 350 29 204 204 CD cord-287123-ldkuwcc7 350 30 ] ] -RRB- cord-287123-ldkuwcc7 350 31 [ [ -LRB- cord-287123-ldkuwcc7 350 32 205 205 CD cord-287123-ldkuwcc7 350 33 ] ] -RRB- cord-287123-ldkuwcc7 350 34 . . . cord-287123-ldkuwcc7 351 1 They -PRON- PRP cord-287123-ldkuwcc7 351 2 were be VBD cord-287123-ldkuwcc7 351 3 reported report VBN cord-287123-ldkuwcc7 351 4 to to TO cord-287123-ldkuwcc7 351 5 competitively competitively RB cord-287123-ldkuwcc7 351 6 bind bind VB cord-287123-ldkuwcc7 351 7 to to IN cord-287123-ldkuwcc7 351 8 FPR2 FPR2 NNP cord-287123-ldkuwcc7 351 9 with with IN cord-287123-ldkuwcc7 351 10 K K NNP cord-287123-ldkuwcc7 352 1 i i PRP cord-287123-ldkuwcc7 352 2 values value VBZ cord-287123-ldkuwcc7 352 3 of of IN cord-287123-ldkuwcc7 352 4 0.21 0.21 CD cord-287123-ldkuwcc7 352 5 , , , cord-287123-ldkuwcc7 352 6 1.8 1.8 CD cord-287123-ldkuwcc7 352 7 and and CC cord-287123-ldkuwcc7 352 8 3.2 3.2 CD cord-287123-ldkuwcc7 352 9 µM. µm. JJ cord-287123-ldkuwcc7 353 1 The the DT cord-287123-ldkuwcc7 353 2 subsequent subsequent JJ cord-287123-ldkuwcc7 353 3 functional functional JJ cord-287123-ldkuwcc7 353 4 analysis analysis NN cord-287123-ldkuwcc7 353 5 revealed reveal VBD cord-287123-ldkuwcc7 353 6 no no DT cord-287123-ldkuwcc7 353 7 direct direct JJ cord-287123-ldkuwcc7 353 8 agonistic agonistic JJ cord-287123-ldkuwcc7 353 9 effects effect NNS cord-287123-ldkuwcc7 353 10 in in IN cord-287123-ldkuwcc7 353 11 one one CD cord-287123-ldkuwcc7 353 12 of of IN cord-287123-ldkuwcc7 353 13 the the DT cord-287123-ldkuwcc7 353 14 most most RBS cord-287123-ldkuwcc7 353 15 potent potent JJ cord-287123-ldkuwcc7 353 16 compounds compound NNS cord-287123-ldkuwcc7 353 17 [ [ -LRB- cord-287123-ldkuwcc7 353 18 200 200 CD cord-287123-ldkuwcc7 353 19 ] ] -RRB- cord-287123-ldkuwcc7 353 20 . . . cord-287123-ldkuwcc7 354 1 More More JJR cord-287123-ldkuwcc7 354 2 information information NN cord-287123-ldkuwcc7 354 3 and and CC cord-287123-ldkuwcc7 354 4 analysis analysis NN cord-287123-ldkuwcc7 354 5 are be VBP cord-287123-ldkuwcc7 354 6 provided provide VBN cord-287123-ldkuwcc7 354 7 in in IN cord-287123-ldkuwcc7 354 8 recent recent JJ cord-287123-ldkuwcc7 354 9 reviews review NNS cord-287123-ldkuwcc7 354 10 [ [ -LRB- cord-287123-ldkuwcc7 354 11 6 6 CD cord-287123-ldkuwcc7 354 12 , , , cord-287123-ldkuwcc7 354 13 200 200 CD cord-287123-ldkuwcc7 354 14 ] ] -RRB- cord-287123-ldkuwcc7 354 15 . . . cord-287123-ldkuwcc7 355 1 In in IN cord-287123-ldkuwcc7 355 2 summary summary NN cord-287123-ldkuwcc7 355 3 , , , cord-287123-ldkuwcc7 355 4 future future JJ cord-287123-ldkuwcc7 355 5 studies study NNS cord-287123-ldkuwcc7 355 6 of of IN cord-287123-ldkuwcc7 355 7 binding bind VBG cord-287123-ldkuwcc7 355 8 properties property NNS cord-287123-ldkuwcc7 355 9 and and CC cord-287123-ldkuwcc7 355 10 off off IN cord-287123-ldkuwcc7 355 11 - - HYPH cord-287123-ldkuwcc7 355 12 target target NN cord-287123-ldkuwcc7 355 13 effects effect NNS cord-287123-ldkuwcc7 355 14 are be VBP cord-287123-ldkuwcc7 355 15 needed need VBN cord-287123-ldkuwcc7 355 16 to to TO cord-287123-ldkuwcc7 355 17 determine determine VB cord-287123-ldkuwcc7 355 18 the the DT cord-287123-ldkuwcc7 355 19 bona bona JJ cord-287123-ldkuwcc7 355 20 fide fide JJ cord-287123-ldkuwcc7 355 21 antagonists antagonist NNS cord-287123-ldkuwcc7 355 22 among among IN cord-287123-ldkuwcc7 355 23 compounds compound NNS cord-287123-ldkuwcc7 355 24 that that WDT cord-287123-ldkuwcc7 355 25 have have VBP cord-287123-ldkuwcc7 355 26 been be VBN cord-287123-ldkuwcc7 355 27 identified identify VBN cord-287123-ldkuwcc7 355 28 to to TO cord-287123-ldkuwcc7 355 29 suppress suppress VB cord-287123-ldkuwcc7 355 30 FPR fpr NN cord-287123-ldkuwcc7 355 31 agonist agonist NN cord-287123-ldkuwcc7 355 32 - - HYPH cord-287123-ldkuwcc7 355 33 stimulated stimulate VBN cord-287123-ldkuwcc7 355 34 cell cell NN cord-287123-ldkuwcc7 355 35 responses response NNS cord-287123-ldkuwcc7 355 36 in in IN cord-287123-ldkuwcc7 355 37 functional functional JJ cord-287123-ldkuwcc7 355 38 activity activity NN cord-287123-ldkuwcc7 355 39 assays assay NNS cord-287123-ldkuwcc7 355 40 . . . cord-287123-ldkuwcc7 356 1 Moreover moreover RB cord-287123-ldkuwcc7 356 2 , , , cord-287123-ldkuwcc7 356 3 most most JJS cord-287123-ldkuwcc7 356 4 of of IN cord-287123-ldkuwcc7 356 5 the the DT cord-287123-ldkuwcc7 356 6 antagonists antagonist NNS cord-287123-ldkuwcc7 356 7 mentioned mention VBN cord-287123-ldkuwcc7 356 8 above above RB cord-287123-ldkuwcc7 356 9 have have VBP cord-287123-ldkuwcc7 356 10 been be VBN cord-287123-ldkuwcc7 356 11 characterized characterize VBN cord-287123-ldkuwcc7 356 12 as as IN cord-287123-ldkuwcc7 356 13 human human JJ cord-287123-ldkuwcc7 356 14 ligands ligand NNS cord-287123-ldkuwcc7 356 15 , , , cord-287123-ldkuwcc7 356 16 and and CC cord-287123-ldkuwcc7 356 17 their -PRON- PRP$ cord-287123-ldkuwcc7 356 18 potency potency NN cord-287123-ldkuwcc7 356 19 and and CC cord-287123-ldkuwcc7 356 20 specificity specificity NN cord-287123-ldkuwcc7 356 21 for for IN cord-287123-ldkuwcc7 356 22 the the DT cord-287123-ldkuwcc7 356 23 murine murine JJ cord-287123-ldkuwcc7 356 24 FPRs fpr NNS cord-287123-ldkuwcc7 356 25 remain remain VBP cord-287123-ldkuwcc7 356 26 to to TO cord-287123-ldkuwcc7 356 27 be be VB cord-287123-ldkuwcc7 356 28 determined determine VBN cord-287123-ldkuwcc7 356 29 . . . cord-287123-ldkuwcc7 357 1 Despite despite IN cord-287123-ldkuwcc7 357 2 the the DT cord-287123-ldkuwcc7 357 3 lack lack NN cord-287123-ldkuwcc7 357 4 of of IN cord-287123-ldkuwcc7 357 5 crystal crystal NN cord-287123-ldkuwcc7 357 6 structures structure NNS cord-287123-ldkuwcc7 357 7 , , , cord-287123-ldkuwcc7 357 8 efforts effort NNS cord-287123-ldkuwcc7 357 9 in in IN cord-287123-ldkuwcc7 357 10 understanding understand VBG cord-287123-ldkuwcc7 357 11 FPR fpr NN cord-287123-ldkuwcc7 357 12 structure structure NN cord-287123-ldkuwcc7 357 13 - - HYPH cord-287123-ldkuwcc7 357 14 function function NN cord-287123-ldkuwcc7 357 15 relationship relationship NN cord-287123-ldkuwcc7 357 16 has have VBZ cord-287123-ldkuwcc7 357 17 been be VBN cord-287123-ldkuwcc7 357 18 propelled propel VBN cord-287123-ldkuwcc7 357 19 with with IN cord-287123-ldkuwcc7 357 20 approaches approach NNS cord-287123-ldkuwcc7 357 21 of of IN cord-287123-ldkuwcc7 357 22 molecular molecular JJ cord-287123-ldkuwcc7 357 23 modification modification NN cord-287123-ldkuwcc7 357 24 ( ( -LRB- cord-287123-ldkuwcc7 357 25 including include VBG cord-287123-ldkuwcc7 357 26 construction construction NN cord-287123-ldkuwcc7 357 27 of of IN cord-287123-ldkuwcc7 357 28 receptor receptor NN cord-287123-ldkuwcc7 357 29 chimera chimera NN cord-287123-ldkuwcc7 357 30 and and CC cord-287123-ldkuwcc7 357 31 site site NN cord-287123-ldkuwcc7 357 32 - - HYPH cord-287123-ldkuwcc7 357 33 directed direct VBN cord-287123-ldkuwcc7 357 34 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 357 35 ) ) -RRB- cord-287123-ldkuwcc7 357 36 and and CC cord-287123-ldkuwcc7 357 37 computational computational JJ cord-287123-ldkuwcc7 357 38 docking docking NN cord-287123-ldkuwcc7 357 39 studies study NNS cord-287123-ldkuwcc7 357 40 . . . cord-287123-ldkuwcc7 358 1 Several several JJ cord-287123-ldkuwcc7 358 2 clusters cluster NNS cord-287123-ldkuwcc7 358 3 of of IN cord-287123-ldkuwcc7 358 4 key key JJ cord-287123-ldkuwcc7 358 5 residues residue NNS cord-287123-ldkuwcc7 358 6 have have VBP cord-287123-ldkuwcc7 358 7 been be VBN cord-287123-ldkuwcc7 358 8 identified identify VBN cord-287123-ldkuwcc7 358 9 to to TO cord-287123-ldkuwcc7 358 10 be be VB cord-287123-ldkuwcc7 358 11 crucial crucial JJ cord-287123-ldkuwcc7 358 12 for for IN cord-287123-ldkuwcc7 358 13 the the DT cord-287123-ldkuwcc7 358 14 interaction interaction NN cord-287123-ldkuwcc7 358 15 between between IN cord-287123-ldkuwcc7 358 16 FPRs fpr NNS cord-287123-ldkuwcc7 358 17 and and CC cord-287123-ldkuwcc7 358 18 various various JJ cord-287123-ldkuwcc7 358 19 modulators modulator NNS cord-287123-ldkuwcc7 358 20 with with IN cord-287123-ldkuwcc7 358 21 highly highly RB cord-287123-ldkuwcc7 358 22 divergent divergent JJ cord-287123-ldkuwcc7 358 23 profiles profile NNS cord-287123-ldkuwcc7 358 24 and and CC cord-287123-ldkuwcc7 358 25 properties property NNS cord-287123-ldkuwcc7 358 26 . . . cord-287123-ldkuwcc7 359 1 Mutational Mutational NNP cord-287123-ldkuwcc7 359 2 studies study NNS cord-287123-ldkuwcc7 359 3 have have VBP cord-287123-ldkuwcc7 359 4 confirmed confirm VBN cord-287123-ldkuwcc7 359 5 the the DT cord-287123-ldkuwcc7 359 6 individual individual JJ cord-287123-ldkuwcc7 359 7 functions function NNS cord-287123-ldkuwcc7 359 8 of of IN cord-287123-ldkuwcc7 359 9 some some DT cord-287123-ldkuwcc7 359 10 of of IN cord-287123-ldkuwcc7 359 11 these these DT cord-287123-ldkuwcc7 359 12 residues residue NNS cord-287123-ldkuwcc7 359 13 in in IN cord-287123-ldkuwcc7 359 14 FPR fpr NN cord-287123-ldkuwcc7 359 15 - - HYPH cord-287123-ldkuwcc7 359 16 ligand ligand NN cord-287123-ldkuwcc7 359 17 interaction interaction NN cord-287123-ldkuwcc7 359 18 [ [ -LRB- cord-287123-ldkuwcc7 359 19 96 96 CD cord-287123-ldkuwcc7 359 20 ] ] -RRB- cord-287123-ldkuwcc7 359 21 . . . cord-287123-ldkuwcc7 360 1 Using use VBG cord-287123-ldkuwcc7 360 2 receptor receptor NN cord-287123-ldkuwcc7 360 3 chimeras chimera NNS cord-287123-ldkuwcc7 360 4 constructed construct VBN cord-287123-ldkuwcc7 360 5 by by IN cord-287123-ldkuwcc7 360 6 domain domain NN cord-287123-ldkuwcc7 360 7 swapping swapping NN cord-287123-ldkuwcc7 360 8 between between IN cord-287123-ldkuwcc7 360 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 360 10 / / SYM cord-287123-ldkuwcc7 360 11 FPR2 FPR2 NNP cord-287123-ldkuwcc7 360 12 [ [ -LRB- cord-287123-ldkuwcc7 360 13 206 206 CD cord-287123-ldkuwcc7 360 14 ] ] -RRB- cord-287123-ldkuwcc7 360 15 and and CC cord-287123-ldkuwcc7 360 16 FPR1 FPR1 NNP cord-287123-ldkuwcc7 360 17 / / SYM cord-287123-ldkuwcc7 360 18 C5aR C5aR NNP cord-287123-ldkuwcc7 360 19 [ [ -LRB- cord-287123-ldkuwcc7 360 20 207 207 CD cord-287123-ldkuwcc7 360 21 ] ] -RRB- cord-287123-ldkuwcc7 360 22 , , , cord-287123-ldkuwcc7 360 23 early early JJ cord-287123-ldkuwcc7 360 24 studies study NNS cord-287123-ldkuwcc7 360 25 demonstrated demonstrate VBD cord-287123-ldkuwcc7 360 26 that that IN cord-287123-ldkuwcc7 360 27 the the DT cord-287123-ldkuwcc7 360 28 first first JJ cord-287123-ldkuwcc7 360 29 , , , cord-287123-ldkuwcc7 360 30 second second JJ cord-287123-ldkuwcc7 360 31 and and CC cord-287123-ldkuwcc7 360 32 third third JJ cord-287123-ldkuwcc7 360 33 extracellular extracellular JJ cord-287123-ldkuwcc7 360 34 loops loop NNS cord-287123-ldkuwcc7 360 35 and and CC cord-287123-ldkuwcc7 360 36 adjacent adjacent JJ cord-287123-ldkuwcc7 360 37 membrane membrane NN cord-287123-ldkuwcc7 360 38 regions region NNS cord-287123-ldkuwcc7 360 39 seem seem VBP cord-287123-ldkuwcc7 360 40 to to TO cord-287123-ldkuwcc7 360 41 be be VB cord-287123-ldkuwcc7 360 42 important important JJ cord-287123-ldkuwcc7 360 43 for for IN cord-287123-ldkuwcc7 360 44 recognition recognition NN cord-287123-ldkuwcc7 360 45 of of IN cord-287123-ldkuwcc7 360 46 fMLF fMLF NNP cord-287123-ldkuwcc7 360 47 . . . cord-287123-ldkuwcc7 361 1 This this DT cord-287123-ldkuwcc7 361 2 approach approach NN cord-287123-ldkuwcc7 361 3 was be VBD cord-287123-ldkuwcc7 361 4 also also RB cord-287123-ldkuwcc7 361 5 taken take VBN cord-287123-ldkuwcc7 361 6 to to TO cord-287123-ldkuwcc7 361 7 study study VB cord-287123-ldkuwcc7 361 8 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 361 9 mediated mediate VBN cord-287123-ldkuwcc7 361 10 by by IN cord-287123-ldkuwcc7 361 11 FPRs fpr NNS cord-287123-ldkuwcc7 361 12 [ [ -LRB- cord-287123-ldkuwcc7 361 13 208 208 CD cord-287123-ldkuwcc7 361 14 ] ] -RRB- cord-287123-ldkuwcc7 361 15 . . . cord-287123-ldkuwcc7 362 1 Following follow VBG cord-287123-ldkuwcc7 362 2 these these DT cord-287123-ldkuwcc7 362 3 studies study NNS cord-287123-ldkuwcc7 362 4 , , , cord-287123-ldkuwcc7 362 5 point point NN cord-287123-ldkuwcc7 362 6 mutations mutation NNS cord-287123-ldkuwcc7 362 7 were be VBD cord-287123-ldkuwcc7 362 8 introduced introduce VBN cord-287123-ldkuwcc7 362 9 into into IN cord-287123-ldkuwcc7 362 10 both both DT cord-287123-ldkuwcc7 362 11 FPRs fpr NNS cord-287123-ldkuwcc7 362 12 , , , cord-287123-ldkuwcc7 362 13 resulting result VBG cord-287123-ldkuwcc7 362 14 in in IN cord-287123-ldkuwcc7 362 15 the the DT cord-287123-ldkuwcc7 362 16 identification identification NN cord-287123-ldkuwcc7 362 17 of of IN cord-287123-ldkuwcc7 362 18 multiple multiple JJ cord-287123-ldkuwcc7 362 19 charged charge VBN cord-287123-ldkuwcc7 362 20 amino amino NN cord-287123-ldkuwcc7 362 21 acids acid NNS cord-287123-ldkuwcc7 362 22 that that WDT cord-287123-ldkuwcc7 362 23 are be VBP cord-287123-ldkuwcc7 362 24 important important JJ cord-287123-ldkuwcc7 362 25 for for IN cord-287123-ldkuwcc7 362 26 the the DT cord-287123-ldkuwcc7 362 27 interaction interaction NN cord-287123-ldkuwcc7 362 28 with with IN cord-287123-ldkuwcc7 362 29 fMLF fMLF NNP cord-287123-ldkuwcc7 362 30 [ [ -LRB- cord-287123-ldkuwcc7 362 31 209 209 CD cord-287123-ldkuwcc7 362 32 ] ] -RRB- cord-287123-ldkuwcc7 362 33 [ [ -LRB- cord-287123-ldkuwcc7 362 34 210 210 CD cord-287123-ldkuwcc7 362 35 ] ] -RRB- cord-287123-ldkuwcc7 362 36 [ [ -LRB- cord-287123-ldkuwcc7 362 37 211 211 CD cord-287123-ldkuwcc7 362 38 ] ] -RRB- cord-287123-ldkuwcc7 362 39 [ [ -LRB- cord-287123-ldkuwcc7 362 40 212 212 CD cord-287123-ldkuwcc7 362 41 ] ] -RRB- cord-287123-ldkuwcc7 362 42 . . . cord-287123-ldkuwcc7 363 1 These these DT cord-287123-ldkuwcc7 363 2 non non JJ cord-287123-ldkuwcc7 363 3 - - JJ cord-287123-ldkuwcc7 363 4 contiguous contiguous JJ cord-287123-ldkuwcc7 363 5 residues residue NNS cord-287123-ldkuwcc7 363 6 include include VBP cord-287123-ldkuwcc7 363 7 Arg Arg NNP cord-287123-ldkuwcc7 363 8 84 84 CD cord-287123-ldkuwcc7 363 9 , , , cord-287123-ldkuwcc7 363 10 Lys Lys NNP cord-287123-ldkuwcc7 363 11 85 85 CD cord-287123-ldkuwcc7 363 12 , , , cord-287123-ldkuwcc7 363 13 Arg Arg NNP cord-287123-ldkuwcc7 363 14 163 163 CD cord-287123-ldkuwcc7 363 15 , , , cord-287123-ldkuwcc7 363 16 Arg Arg NNP cord-287123-ldkuwcc7 363 17 205 205 CD cord-287123-ldkuwcc7 363 18 , , , cord-287123-ldkuwcc7 363 19 and and CC cord-287123-ldkuwcc7 363 20 Asp Asp NNP cord-287123-ldkuwcc7 363 21 284 284 CD cord-287123-ldkuwcc7 363 22 in in IN cord-287123-ldkuwcc7 363 23 FPR1 FPR1 NNP cord-287123-ldkuwcc7 364 1 ( ( -LRB- cord-287123-ldkuwcc7 364 2 Figure figure NN cord-287123-ldkuwcc7 364 3 1 1 CD cord-287123-ldkuwcc7 364 4 ) ) -RRB- cord-287123-ldkuwcc7 364 5 . . . cord-287123-ldkuwcc7 365 1 Among among IN cord-287123-ldkuwcc7 365 2 them -PRON- PRP cord-287123-ldkuwcc7 365 3 , , , cord-287123-ldkuwcc7 365 4 Lys Lys NNP cord-287123-ldkuwcc7 365 5 85 85 CD cord-287123-ldkuwcc7 365 6 in in IN cord-287123-ldkuwcc7 365 7 the the DT cord-287123-ldkuwcc7 365 8 second second JJ cord-287123-ldkuwcc7 365 9 transmembrane transmembrane NN cord-287123-ldkuwcc7 365 10 segment segment NN cord-287123-ldkuwcc7 365 11 ( ( -LRB- cord-287123-ldkuwcc7 365 12 TM2 TM2 NNP cord-287123-ldkuwcc7 365 13 ) ) -RRB- cord-287123-ldkuwcc7 365 14 and and CC cord-287123-ldkuwcc7 365 15 Asp Asp NNP cord-287123-ldkuwcc7 365 16 284 284 CD cord-287123-ldkuwcc7 365 17 in in IN cord-287123-ldkuwcc7 365 18 TM7 TM7 NNP cord-287123-ldkuwcc7 365 19 were be VBD cord-287123-ldkuwcc7 365 20 proven prove VBN cord-287123-ldkuwcc7 365 21 essential essential JJ cord-287123-ldkuwcc7 365 22 for for IN cord-287123-ldkuwcc7 365 23 the the DT cord-287123-ldkuwcc7 365 24 high high JJ cord-287123-ldkuwcc7 365 25 - - HYPH cord-287123-ldkuwcc7 365 26 affinity affinity NN cord-287123-ldkuwcc7 365 27 binding binding NN cord-287123-ldkuwcc7 365 28 of of IN cord-287123-ldkuwcc7 365 29 fMLF fmlf NN cord-287123-ldkuwcc7 365 30 [ [ -LRB- cord-287123-ldkuwcc7 365 31 212 212 CD cord-287123-ldkuwcc7 365 32 , , , cord-287123-ldkuwcc7 365 33 213 213 CD cord-287123-ldkuwcc7 365 34 ] ] -RRB- cord-287123-ldkuwcc7 365 35 . . . cord-287123-ldkuwcc7 366 1 It -PRON- PRP cord-287123-ldkuwcc7 366 2 is be VBZ cord-287123-ldkuwcc7 366 3 suggested suggest VBN cord-287123-ldkuwcc7 366 4 that that IN cord-287123-ldkuwcc7 366 5 binding binding NN cord-287123-ldkuwcc7 366 6 of of IN cord-287123-ldkuwcc7 366 7 fMLF fmlf NN cord-287123-ldkuwcc7 366 8 to to IN cord-287123-ldkuwcc7 366 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 366 10 disrupts disrupt VBZ cord-287123-ldkuwcc7 366 11 the the DT cord-287123-ldkuwcc7 366 12 electrostatic electrostatic JJ cord-287123-ldkuwcc7 366 13 interaction interaction NN cord-287123-ldkuwcc7 366 14 between between IN cord-287123-ldkuwcc7 366 15 Lys Lys NNP cord-287123-ldkuwcc7 366 16 85 85 CD cord-287123-ldkuwcc7 366 17 and and CC cord-287123-ldkuwcc7 366 18 Asp Asp NNP cord-287123-ldkuwcc7 366 19 284 284 CD cord-287123-ldkuwcc7 366 20 , , , cord-287123-ldkuwcc7 366 21 which which WDT cord-287123-ldkuwcc7 366 22 might may MD cord-287123-ldkuwcc7 366 23 contribute contribute VB cord-287123-ldkuwcc7 366 24 to to IN cord-287123-ldkuwcc7 366 25 the the DT cord-287123-ldkuwcc7 366 26 receptor receptor NN cord-287123-ldkuwcc7 366 27 activation activation NN cord-287123-ldkuwcc7 366 28 [ [ -LRB- cord-287123-ldkuwcc7 366 29 212 212 CD cord-287123-ldkuwcc7 366 30 , , , cord-287123-ldkuwcc7 366 31 214 214 CD cord-287123-ldkuwcc7 366 32 , , , cord-287123-ldkuwcc7 366 33 215 215 CD cord-287123-ldkuwcc7 366 34 ] ] -RRB- cord-287123-ldkuwcc7 367 1 ( ( -LRB- cord-287123-ldkuwcc7 367 2 Figure figure NN cord-287123-ldkuwcc7 367 3 2 2 CD cord-287123-ldkuwcc7 367 4 ) ) -RRB- cord-287123-ldkuwcc7 367 5 . . . cord-287123-ldkuwcc7 368 1 The the DT cord-287123-ldkuwcc7 368 2 lack lack NN cord-287123-ldkuwcc7 368 3 of of IN cord-287123-ldkuwcc7 368 4 a a DT cord-287123-ldkuwcc7 368 5 ' ' `` cord-287123-ldkuwcc7 368 6 salt salt NN cord-287123-ldkuwcc7 368 7 bridge bridge NN cord-287123-ldkuwcc7 368 8 ' ' '' cord-287123-ldkuwcc7 368 9 formed form VBN cord-287123-ldkuwcc7 368 10 by by IN cord-287123-ldkuwcc7 368 11 Lys Lys NNP cord-287123-ldkuwcc7 368 12 / / SYM cord-287123-ldkuwcc7 368 13 Asp Asp NNP cord-287123-ldkuwcc7 368 14 in in IN cord-287123-ldkuwcc7 368 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 368 16 ( ( -LRB- cord-287123-ldkuwcc7 368 17 becoming become VBG cord-287123-ldkuwcc7 368 18 Met Met NNP cord-287123-ldkuwcc7 368 19 and and CC cord-287123-ldkuwcc7 368 20 Asn Asn NNP cord-287123-ldkuwcc7 368 21 in in IN cord-287123-ldkuwcc7 368 22 corresponding correspond VBG cord-287123-ldkuwcc7 368 23 positions position NNS cord-287123-ldkuwcc7 368 24 ) ) -RRB- cord-287123-ldkuwcc7 368 25 is be VBZ cord-287123-ldkuwcc7 368 26 responsible responsible JJ cord-287123-ldkuwcc7 368 27 for for IN cord-287123-ldkuwcc7 368 28 the the DT cord-287123-ldkuwcc7 368 29 low low JJ cord-287123-ldkuwcc7 368 30 affinity affinity NN cord-287123-ldkuwcc7 368 31 binding binding NN cord-287123-ldkuwcc7 368 32 of of IN cord-287123-ldkuwcc7 368 33 fMLF fmlf NN cord-287123-ldkuwcc7 368 34 and and CC cord-287123-ldkuwcc7 368 35 most most JJS cord-287123-ldkuwcc7 368 36 formyl formyl NNP cord-287123-ldkuwcc7 368 37 peptide peptide NN cord-287123-ldkuwcc7 368 38 , , , cord-287123-ldkuwcc7 368 39 although although IN cord-287123-ldkuwcc7 368 40 it -PRON- PRP cord-287123-ldkuwcc7 368 41 can can MD cord-287123-ldkuwcc7 368 42 not not RB cord-287123-ldkuwcc7 368 43 explain explain VB cord-287123-ldkuwcc7 368 44 the the DT cord-287123-ldkuwcc7 368 45 relatively relatively RB cord-287123-ldkuwcc7 368 46 effective effective JJ cord-287123-ldkuwcc7 368 47 recognition recognition NN cord-287123-ldkuwcc7 368 48 by by IN cord-287123-ldkuwcc7 368 49 formyl formyl NNP cord-287123-ldkuwcc7 368 50 peptides peptide NNS cord-287123-ldkuwcc7 368 51 of of IN cord-287123-ldkuwcc7 368 52 other other JJ cord-287123-ldkuwcc7 368 53 compositions composition NNS cord-287123-ldkuwcc7 368 54 and and CC cord-287123-ldkuwcc7 368 55 lengths length NNS cord-287123-ldkuwcc7 368 56 . . . cord-287123-ldkuwcc7 369 1 Arg Arg NNP cord-287123-ldkuwcc7 369 2 163 163 CD cord-287123-ldkuwcc7 369 3 , , , cord-287123-ldkuwcc7 369 4 Arg Arg NNP cord-287123-ldkuwcc7 369 5 205 205 CD cord-287123-ldkuwcc7 369 6 , , , cord-287123-ldkuwcc7 369 7 and and CC cord-287123-ldkuwcc7 369 8 Asp Asp NNP cord-287123-ldkuwcc7 369 9 284 284 CD cord-287123-ldkuwcc7 369 10 in in IN cord-287123-ldkuwcc7 369 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 369 12 ( ( -LRB- cord-287123-ldkuwcc7 369 13 Figure figure NN cord-287123-ldkuwcc7 369 14 1 1 CD cord-287123-ldkuwcc7 369 15 ) ) -RRB- cord-287123-ldkuwcc7 369 16 . . . cord-287123-ldkuwcc7 370 1 Among among IN cord-287123-ldkuwcc7 370 2 them -PRON- PRP cord-287123-ldkuwcc7 370 3 , , , cord-287123-ldkuwcc7 370 4 Lys Lys NNP cord-287123-ldkuwcc7 370 5 85 85 CD cord-287123-ldkuwcc7 370 6 in in IN cord-287123-ldkuwcc7 370 7 the the DT cord-287123-ldkuwcc7 370 8 second second JJ cord-287123-ldkuwcc7 370 9 transmembrane transmembrane NN cord-287123-ldkuwcc7 370 10 segment segment NN cord-287123-ldkuwcc7 370 11 ( ( -LRB- cord-287123-ldkuwcc7 370 12 TM2 TM2 NNP cord-287123-ldkuwcc7 370 13 ) ) -RRB- cord-287123-ldkuwcc7 370 14 and and CC cord-287123-ldkuwcc7 370 15 Asp Asp NNP cord-287123-ldkuwcc7 370 16 284 284 CD cord-287123-ldkuwcc7 370 17 in in IN cord-287123-ldkuwcc7 370 18 TM7 TM7 NNP cord-287123-ldkuwcc7 370 19 were be VBD cord-287123-ldkuwcc7 370 20 proven prove VBN cord-287123-ldkuwcc7 370 21 essential essential JJ cord-287123-ldkuwcc7 370 22 for for IN cord-287123-ldkuwcc7 370 23 the the DT cord-287123-ldkuwcc7 370 24 high high JJ cord-287123-ldkuwcc7 370 25 - - HYPH cord-287123-ldkuwcc7 370 26 affinity affinity NN cord-287123-ldkuwcc7 370 27 binding binding NN cord-287123-ldkuwcc7 370 28 of of IN cord-287123-ldkuwcc7 370 29 fMLF fmlf NN cord-287123-ldkuwcc7 370 30 [ [ -LRB- cord-287123-ldkuwcc7 370 31 212 212 CD cord-287123-ldkuwcc7 370 32 , , , cord-287123-ldkuwcc7 370 33 213 213 CD cord-287123-ldkuwcc7 370 34 ] ] -RRB- cord-287123-ldkuwcc7 370 35 . . . cord-287123-ldkuwcc7 371 1 It -PRON- PRP cord-287123-ldkuwcc7 371 2 is be VBZ cord-287123-ldkuwcc7 371 3 suggested suggest VBN cord-287123-ldkuwcc7 371 4 that that IN cord-287123-ldkuwcc7 371 5 binding binding NN cord-287123-ldkuwcc7 371 6 of of IN cord-287123-ldkuwcc7 371 7 fMLF fmlf NN cord-287123-ldkuwcc7 371 8 to to IN cord-287123-ldkuwcc7 371 9 FPR1 FPR1 NNP cord-287123-ldkuwcc7 371 10 disrupts disrupt VBZ cord-287123-ldkuwcc7 371 11 the the DT cord-287123-ldkuwcc7 371 12 electrostatic electrostatic JJ cord-287123-ldkuwcc7 371 13 interaction interaction NN cord-287123-ldkuwcc7 371 14 between between IN cord-287123-ldkuwcc7 371 15 Lys Lys NNP cord-287123-ldkuwcc7 371 16 85 85 CD cord-287123-ldkuwcc7 371 17 and and CC cord-287123-ldkuwcc7 371 18 Asp Asp NNP cord-287123-ldkuwcc7 371 19 284 284 CD cord-287123-ldkuwcc7 371 20 , , , cord-287123-ldkuwcc7 371 21 which which WDT cord-287123-ldkuwcc7 371 22 might may MD cord-287123-ldkuwcc7 371 23 contribute contribute VB cord-287123-ldkuwcc7 371 24 to to IN cord-287123-ldkuwcc7 371 25 the the DT cord-287123-ldkuwcc7 371 26 receptor receptor NN cord-287123-ldkuwcc7 371 27 activation activation NN cord-287123-ldkuwcc7 371 28 [ [ -LRB- cord-287123-ldkuwcc7 371 29 212 212 CD cord-287123-ldkuwcc7 371 30 , , , cord-287123-ldkuwcc7 371 31 214 214 CD cord-287123-ldkuwcc7 371 32 , , , cord-287123-ldkuwcc7 371 33 215 215 CD cord-287123-ldkuwcc7 371 34 ] ] -RRB- cord-287123-ldkuwcc7 372 1 ( ( -LRB- cord-287123-ldkuwcc7 372 2 Figure figure NN cord-287123-ldkuwcc7 372 3 2 2 CD cord-287123-ldkuwcc7 372 4 ) ) -RRB- cord-287123-ldkuwcc7 372 5 . . . cord-287123-ldkuwcc7 373 1 The the DT cord-287123-ldkuwcc7 373 2 lack lack NN cord-287123-ldkuwcc7 373 3 of of IN cord-287123-ldkuwcc7 373 4 a a DT cord-287123-ldkuwcc7 373 5 ' ' `` cord-287123-ldkuwcc7 373 6 salt salt NN cord-287123-ldkuwcc7 373 7 bridge bridge NN cord-287123-ldkuwcc7 373 8 ' ' '' cord-287123-ldkuwcc7 373 9 formed form VBN cord-287123-ldkuwcc7 373 10 by by IN cord-287123-ldkuwcc7 373 11 Lys Lys NNP cord-287123-ldkuwcc7 373 12 / / SYM cord-287123-ldkuwcc7 373 13 Asp Asp NNP cord-287123-ldkuwcc7 373 14 in in IN cord-287123-ldkuwcc7 373 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 373 16 ( ( -LRB- cord-287123-ldkuwcc7 373 17 becoming become VBG cord-287123-ldkuwcc7 373 18 Met Met NNP cord-287123-ldkuwcc7 373 19 and and CC cord-287123-ldkuwcc7 373 20 Asn Asn NNP cord-287123-ldkuwcc7 373 21 in in IN cord-287123-ldkuwcc7 373 22 corresponding correspond VBG cord-287123-ldkuwcc7 373 23 positions position NNS cord-287123-ldkuwcc7 373 24 ) ) -RRB- cord-287123-ldkuwcc7 373 25 is be VBZ cord-287123-ldkuwcc7 373 26 responsible responsible JJ cord-287123-ldkuwcc7 373 27 for for IN cord-287123-ldkuwcc7 373 28 the the DT cord-287123-ldkuwcc7 373 29 low low JJ cord-287123-ldkuwcc7 373 30 affinity affinity NN cord-287123-ldkuwcc7 373 31 binding binding NN cord-287123-ldkuwcc7 373 32 of of IN cord-287123-ldkuwcc7 373 33 fMLF fmlf NN cord-287123-ldkuwcc7 373 34 and and CC cord-287123-ldkuwcc7 373 35 most most JJS cord-287123-ldkuwcc7 373 36 formyl formyl NNP cord-287123-ldkuwcc7 373 37 peptide peptide NN cord-287123-ldkuwcc7 373 38 , , , cord-287123-ldkuwcc7 373 39 although although IN cord-287123-ldkuwcc7 373 40 it -PRON- PRP cord-287123-ldkuwcc7 373 41 can can MD cord-287123-ldkuwcc7 373 42 not not RB cord-287123-ldkuwcc7 373 43 explain explain VB cord-287123-ldkuwcc7 373 44 the the DT cord-287123-ldkuwcc7 373 45 relatively relatively RB cord-287123-ldkuwcc7 373 46 effective effective JJ cord-287123-ldkuwcc7 373 47 recognition recognition NN cord-287123-ldkuwcc7 373 48 by by IN cord-287123-ldkuwcc7 373 49 formyl formyl NNP cord-287123-ldkuwcc7 373 50 peptides peptide NNS cord-287123-ldkuwcc7 373 51 of of IN cord-287123-ldkuwcc7 373 52 other other JJ cord-287123-ldkuwcc7 373 53 compositions composition NNS cord-287123-ldkuwcc7 373 54 and and CC cord-287123-ldkuwcc7 373 55 lengths length NNS cord-287123-ldkuwcc7 373 56 . . . cord-287123-ldkuwcc7 374 1 Figure figure NN cord-287123-ldkuwcc7 374 2 1 1 CD cord-287123-ldkuwcc7 374 3 ) ) -RRB- cord-287123-ldkuwcc7 374 4 . . . cord-287123-ldkuwcc7 375 1 Reproduced reproduce VBN cord-287123-ldkuwcc7 375 2 from from IN cord-287123-ldkuwcc7 375 3 [ [ -LRB- cord-287123-ldkuwcc7 375 4 96 96 CD cord-287123-ldkuwcc7 375 5 ] ] -RRB- cord-287123-ldkuwcc7 375 6 with with IN cord-287123-ldkuwcc7 375 7 permission permission NN cord-287123-ldkuwcc7 375 8 . . . cord-287123-ldkuwcc7 376 1 Using use VBG cord-287123-ldkuwcc7 376 2 a a DT cord-287123-ldkuwcc7 376 3 similar similar JJ cord-287123-ldkuwcc7 376 4 approach approach NN cord-287123-ldkuwcc7 376 5 of of IN cord-287123-ldkuwcc7 376 6 site site NN cord-287123-ldkuwcc7 376 7 - - HYPH cord-287123-ldkuwcc7 376 8 directed direct VBN cord-287123-ldkuwcc7 376 9 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 376 10 aided aid VBN cord-287123-ldkuwcc7 376 11 by by IN cord-287123-ldkuwcc7 376 12 computer computer NN cord-287123-ldkuwcc7 376 13 modeling modeling NN cord-287123-ldkuwcc7 376 14 , , , cord-287123-ldkuwcc7 376 15 another another DT cord-287123-ldkuwcc7 376 16 charged charge VBN cord-287123-ldkuwcc7 376 17 residue residue NN cord-287123-ldkuwcc7 376 18 Asp Asp NNP cord-287123-ldkuwcc7 376 19 281 281 CD cord-287123-ldkuwcc7 376 20 in in IN cord-287123-ldkuwcc7 376 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 376 22 ( ( -LRB- cord-287123-ldkuwcc7 376 23 Gly Gly NNP cord-287123-ldkuwcc7 376 24 280 280 CD cord-287123-ldkuwcc7 376 25 in in IN cord-287123-ldkuwcc7 376 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 376 27 ) ) -RRB- cord-287123-ldkuwcc7 376 28 was be VBD cord-287123-ldkuwcc7 376 29 found find VBN cord-287123-ldkuwcc7 376 30 to to TO cord-287123-ldkuwcc7 376 31 be be VB cord-287123-ldkuwcc7 376 32 crucial crucial JJ cord-287123-ldkuwcc7 376 33 for for IN cord-287123-ldkuwcc7 376 34 the the DT cord-287123-ldkuwcc7 376 35 interaction interaction NN cord-287123-ldkuwcc7 376 36 of of IN cord-287123-ldkuwcc7 376 37 FPR2 FPR2 NNP cord-287123-ldkuwcc7 376 38 with with IN cord-287123-ldkuwcc7 376 39 certain certain JJ cord-287123-ldkuwcc7 376 40 formyl formyl NN cord-287123-ldkuwcc7 376 41 peptides peptide NNS cord-287123-ldkuwcc7 376 42 that that WDT cord-287123-ldkuwcc7 376 43 contain contain VBP cord-287123-ldkuwcc7 376 44 a a DT cord-287123-ldkuwcc7 376 45 positively positively RB cord-287123-ldkuwcc7 376 46 charged charge VBN cord-287123-ldkuwcc7 376 47 C c NN cord-287123-ldkuwcc7 376 48 - - HYPH cord-287123-ldkuwcc7 376 49 terminal terminal NN cord-287123-ldkuwcc7 376 50 residue residue NN cord-287123-ldkuwcc7 376 51 ( ( -LRB- cord-287123-ldkuwcc7 376 52 Figure Figure NNP cord-287123-ldkuwcc7 376 53 3 3 CD cord-287123-ldkuwcc7 376 54 ) ) -RRB- cord-287123-ldkuwcc7 376 55 , , , cord-287123-ldkuwcc7 376 56 such such JJ cord-287123-ldkuwcc7 376 57 as as IN cord-287123-ldkuwcc7 376 58 Residues residue NNS cord-287123-ldkuwcc7 376 59 referenced reference VBN cord-287123-ldkuwcc7 376 60 in in IN cord-287123-ldkuwcc7 376 61 the the DT cord-287123-ldkuwcc7 376 62 manuscript manuscript NN cord-287123-ldkuwcc7 376 63 are be VBP cord-287123-ldkuwcc7 376 64 boxed box VBN cord-287123-ldkuwcc7 376 65 . . . cord-287123-ldkuwcc7 377 1 Conserved conserved JJ cord-287123-ldkuwcc7 377 2 side side NN cord-287123-ldkuwcc7 377 3 - - HYPH cord-287123-ldkuwcc7 377 4 chains chain NNS cord-287123-ldkuwcc7 377 5 between between IN cord-287123-ldkuwcc7 377 6 both both DT cord-287123-ldkuwcc7 377 7 receptors receptor NNS cord-287123-ldkuwcc7 377 8 are be VBP cord-287123-ldkuwcc7 377 9 shown show VBN cord-287123-ldkuwcc7 377 10 in in IN cord-287123-ldkuwcc7 377 11 black black JJ cord-287123-ldkuwcc7 377 12 , , , cord-287123-ldkuwcc7 377 13 and and CC cord-287123-ldkuwcc7 377 14 major major JJ cord-287123-ldkuwcc7 377 15 differences difference NNS cord-287123-ldkuwcc7 377 16 in in IN cord-287123-ldkuwcc7 377 17 amino amino JJ cord-287123-ldkuwcc7 377 18 acids acid NNS cord-287123-ldkuwcc7 377 19 are be VBP cord-287123-ldkuwcc7 377 20 highlighted highlight VBN cord-287123-ldkuwcc7 377 21 in in IN cord-287123-ldkuwcc7 377 22 green green NN cord-287123-ldkuwcc7 377 23 for for IN cord-287123-ldkuwcc7 377 24 N N NNP cord-287123-ldkuwcc7 377 25 - - HYPH cord-287123-ldkuwcc7 377 26 formyl formyl NNP cord-287123-ldkuwcc7 377 27 peptide peptide NN cord-287123-ldkuwcc7 377 28 binding bind VBG cord-287123-ldkuwcc7 377 29 to to IN cord-287123-ldkuwcc7 377 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 377 31 ) ) -RRB- cord-287123-ldkuwcc7 377 32 or or CC cord-287123-ldkuwcc7 377 33 gray gray JJ cord-287123-ldkuwcc7 377 34 ( ( -LRB- cord-287123-ldkuwcc7 377 35 for for IN cord-287123-ldkuwcc7 377 36 N N NNP cord-287123-ldkuwcc7 377 37 - - HYPH cord-287123-ldkuwcc7 377 38 formyl formyl NNP cord-287123-ldkuwcc7 377 39 peptide peptide NN cord-287123-ldkuwcc7 377 40 binding bind VBG cord-287123-ldkuwcc7 377 41 to to IN cord-287123-ldkuwcc7 377 42 FPR2 FPR2 NNP cord-287123-ldkuwcc7 377 43 ) ) -RRB- cord-287123-ldkuwcc7 377 44 . . . cord-287123-ldkuwcc7 378 1 B B NNP cord-287123-ldkuwcc7 378 2 and and CC cord-287123-ldkuwcc7 378 3 C C NNP cord-287123-ldkuwcc7 378 4 , , , cord-287123-ldkuwcc7 378 5 molecular molecular JJ cord-287123-ldkuwcc7 378 6 electrostatic electrostatic JJ cord-287123-ldkuwcc7 378 7 potential potential NN cord-287123-ldkuwcc7 378 8 on on IN cord-287123-ldkuwcc7 378 9 the the DT cord-287123-ldkuwcc7 378 10 inner inner JJ cord-287123-ldkuwcc7 378 11 surface surface NN cord-287123-ldkuwcc7 378 12 of of IN cord-287123-ldkuwcc7 378 13 the the DT cord-287123-ldkuwcc7 378 14 binding bind VBG cord-287123-ldkuwcc7 378 15 cavity cavity NN cord-287123-ldkuwcc7 378 16 of of IN cord-287123-ldkuwcc7 378 17 a a DT cord-287123-ldkuwcc7 378 18 computational computational JJ cord-287123-ldkuwcc7 378 19 model model NN cord-287123-ldkuwcc7 378 20 of of IN cord-287123-ldkuwcc7 378 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 378 22 ( ( -LRB- cord-287123-ldkuwcc7 378 23 B b NN cord-287123-ldkuwcc7 378 24 ) ) -RRB- cord-287123-ldkuwcc7 378 25 and and CC cord-287123-ldkuwcc7 378 26 FPR2 FPR2 NNP cord-287123-ldkuwcc7 378 27 ( ( -LRB- cord-287123-ldkuwcc7 378 28 C C NNP cord-287123-ldkuwcc7 378 29 ) ) -RRB- cord-287123-ldkuwcc7 378 30 , , , cord-287123-ldkuwcc7 378 31 viewed view VBN cord-287123-ldkuwcc7 378 32 from from IN cord-287123-ldkuwcc7 378 33 top top NN cord-287123-ldkuwcc7 378 34 of of IN cord-287123-ldkuwcc7 378 35 the the DT cord-287123-ldkuwcc7 378 36 receptors receptor NNS cord-287123-ldkuwcc7 378 37 . . . cord-287123-ldkuwcc7 379 1 FPR1 FPR1 NNP cord-287123-ldkuwcc7 379 2 and and CC cord-287123-ldkuwcc7 379 3 FPR2 FPR2 NNP cord-287123-ldkuwcc7 379 4 were be VBD cord-287123-ldkuwcc7 379 5 modeled model VBN cord-287123-ldkuwcc7 379 6 using use VBG cord-287123-ldkuwcc7 379 7 the the DT cord-287123-ldkuwcc7 379 8 structure structure NN cord-287123-ldkuwcc7 379 9 of of IN cord-287123-ldkuwcc7 379 10 the the DT cord-287123-ldkuwcc7 379 11 CXCR4 CXCR4 NNP cord-287123-ldkuwcc7 379 12 chemokine chemokine NN cord-287123-ldkuwcc7 379 13 receptor receptor NN cord-287123-ldkuwcc7 379 14 as as IN cord-287123-ldkuwcc7 379 15 template template NN cord-287123-ldkuwcc7 379 16 . . . cord-287123-ldkuwcc7 380 1 Arrows arrow NNS cord-287123-ldkuwcc7 380 2 show show VBP cord-287123-ldkuwcc7 380 3 key key JJ cord-287123-ldkuwcc7 380 4 positive positive JJ cord-287123-ldkuwcc7 380 5 area area NN cord-287123-ldkuwcc7 380 6 in in IN cord-287123-ldkuwcc7 380 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 380 8 due due IN cord-287123-ldkuwcc7 380 9 to to IN cord-287123-ldkuwcc7 380 10 Arg Arg NNP cord-287123-ldkuwcc7 380 11 84 84 CD cord-287123-ldkuwcc7 380 12 and and CC cord-287123-ldkuwcc7 380 13 Lys Lys NNP cord-287123-ldkuwcc7 380 14 85 85 CD cord-287123-ldkuwcc7 380 15 , , , cord-287123-ldkuwcc7 380 16 and and CC cord-287123-ldkuwcc7 380 17 negative negative JJ cord-287123-ldkuwcc7 380 18 area area NN cord-287123-ldkuwcc7 380 19 in in IN cord-287123-ldkuwcc7 380 20 FPR2 FPR2 NNP cord-287123-ldkuwcc7 380 21 due due IN cord-287123-ldkuwcc7 380 22 to to IN cord-287123-ldkuwcc7 380 23 Asp Asp NNP cord-287123-ldkuwcc7 380 24 281 281 CD cord-287123-ldkuwcc7 380 25 sequence sequence NN cord-287123-ldkuwcc7 380 26 alignment alignment NN cord-287123-ldkuwcc7 380 27 and and CC cord-287123-ldkuwcc7 380 28 location location NN cord-287123-ldkuwcc7 380 29 of of IN cord-287123-ldkuwcc7 380 30 positive positive JJ cord-287123-ldkuwcc7 380 31 selection selection NN cord-287123-ldkuwcc7 380 32 sites site NNS cord-287123-ldkuwcc7 380 33 in in IN cord-287123-ldkuwcc7 380 34 FPR1 FPR1 NNP cord-287123-ldkuwcc7 380 35 , , , cord-287123-ldkuwcc7 380 36 FPR2 FPR2 NNP cord-287123-ldkuwcc7 380 37 and and CC cord-287123-ldkuwcc7 380 38 mFpr1 mFpr1 NNP cord-287123-ldkuwcc7 380 39 ( ( -LRB- cord-287123-ldkuwcc7 380 40 see see VB cord-287123-ldkuwcc7 380 41 also also RB cord-287123-ldkuwcc7 380 42 Figure figure NN cord-287123-ldkuwcc7 380 43 1 1 CD cord-287123-ldkuwcc7 380 44 ) ) -RRB- cord-287123-ldkuwcc7 380 45 . . . cord-287123-ldkuwcc7 381 1 Reproduced reproduce VBN cord-287123-ldkuwcc7 381 2 from from IN cord-287123-ldkuwcc7 381 3 [ [ -LRB- cord-287123-ldkuwcc7 381 4 96 96 CD cord-287123-ldkuwcc7 381 5 ] ] -RRB- cord-287123-ldkuwcc7 381 6 with with IN cord-287123-ldkuwcc7 381 7 permission permission NN cord-287123-ldkuwcc7 381 8 . . . cord-287123-ldkuwcc7 382 1 Using use VBG cord-287123-ldkuwcc7 382 2 a a DT cord-287123-ldkuwcc7 382 3 similar similar JJ cord-287123-ldkuwcc7 382 4 approach approach NN cord-287123-ldkuwcc7 382 5 of of IN cord-287123-ldkuwcc7 382 6 site site NN cord-287123-ldkuwcc7 382 7 - - HYPH cord-287123-ldkuwcc7 382 8 directed direct VBN cord-287123-ldkuwcc7 382 9 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 382 10 aided aid VBN cord-287123-ldkuwcc7 382 11 by by IN cord-287123-ldkuwcc7 382 12 computer computer NN cord-287123-ldkuwcc7 382 13 modeling modeling NN cord-287123-ldkuwcc7 382 14 , , , cord-287123-ldkuwcc7 382 15 another another DT cord-287123-ldkuwcc7 382 16 charged charge VBN cord-287123-ldkuwcc7 382 17 residue residue NN cord-287123-ldkuwcc7 382 18 Asp Asp NNP cord-287123-ldkuwcc7 382 19 281 281 CD cord-287123-ldkuwcc7 382 20 in in IN cord-287123-ldkuwcc7 382 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 382 22 ( ( -LRB- cord-287123-ldkuwcc7 382 23 Gly Gly NNP cord-287123-ldkuwcc7 382 24 280 280 CD cord-287123-ldkuwcc7 382 25 in in IN cord-287123-ldkuwcc7 382 26 FPR1 FPR1 NNP cord-287123-ldkuwcc7 382 27 ) ) -RRB- cord-287123-ldkuwcc7 382 28 was be VBD cord-287123-ldkuwcc7 382 29 found find VBN cord-287123-ldkuwcc7 382 30 to to TO cord-287123-ldkuwcc7 382 31 be be VB cord-287123-ldkuwcc7 382 32 crucial crucial JJ cord-287123-ldkuwcc7 382 33 for for IN cord-287123-ldkuwcc7 382 34 the the DT cord-287123-ldkuwcc7 382 35 interaction interaction NN cord-287123-ldkuwcc7 382 36 of of IN cord-287123-ldkuwcc7 382 37 FPR2 FPR2 NNP cord-287123-ldkuwcc7 382 38 with with IN cord-287123-ldkuwcc7 382 39 certain certain JJ cord-287123-ldkuwcc7 382 40 formyl formyl NN cord-287123-ldkuwcc7 382 41 peptides peptide NNS cord-287123-ldkuwcc7 382 42 that that WDT cord-287123-ldkuwcc7 382 43 contain contain VBP cord-287123-ldkuwcc7 382 44 a a DT cord-287123-ldkuwcc7 382 45 positively positively RB cord-287123-ldkuwcc7 382 46 charged charge VBN cord-287123-ldkuwcc7 382 47 C c NN cord-287123-ldkuwcc7 382 48 - - HYPH cord-287123-ldkuwcc7 382 49 terminal terminal NN cord-287123-ldkuwcc7 382 50 residue residue NN cord-287123-ldkuwcc7 382 51 ( ( -LRB- cord-287123-ldkuwcc7 382 52 Figure Figure NNP cord-287123-ldkuwcc7 382 53 3 3 CD cord-287123-ldkuwcc7 382 54 ) ) -RRB- cord-287123-ldkuwcc7 382 55 , , , cord-287123-ldkuwcc7 382 56 such such JJ cord-287123-ldkuwcc7 382 57 as as IN cord-287123-ldkuwcc7 382 58 Lys Lys NNP cord-287123-ldkuwcc7 382 59 in in IN cord-287123-ldkuwcc7 382 60 fMLFK fmlfk JJ cord-287123-ldkuwcc7 382 61 [ [ -LRB- cord-287123-ldkuwcc7 382 62 96 96 CD cord-287123-ldkuwcc7 382 63 ] ] -RRB- cord-287123-ldkuwcc7 382 64 . . . cord-287123-ldkuwcc7 383 1 In in IN cord-287123-ldkuwcc7 383 2 this this DT cord-287123-ldkuwcc7 383 3 case case NN cord-287123-ldkuwcc7 383 4 , , , cord-287123-ldkuwcc7 383 5 the the DT cord-287123-ldkuwcc7 383 6 formation formation NN cord-287123-ldkuwcc7 383 7 of of IN cord-287123-ldkuwcc7 383 8 ' ' `` cord-287123-ldkuwcc7 383 9 salt salt NNP cord-287123-ldkuwcc7 383 10 bridge bridge NNP cord-287123-ldkuwcc7 383 11 ' ' '' cord-287123-ldkuwcc7 383 12 seems seem VBZ cord-287123-ldkuwcc7 383 13 still still RB cord-287123-ldkuwcc7 383 14 important important JJ cord-287123-ldkuwcc7 383 15 because because IN cord-287123-ldkuwcc7 383 16 the the DT cord-287123-ldkuwcc7 383 17 D281 d281 NN cord-287123-ldkuwcc7 383 18 G g NN cord-287123-ldkuwcc7 383 19 substitution substitution NN cord-287123-ldkuwcc7 383 20 of of IN cord-287123-ldkuwcc7 383 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 383 22 alone alone RB cord-287123-ldkuwcc7 383 23 failed fail VBD cord-287123-ldkuwcc7 383 24 to to TO cord-287123-ldkuwcc7 383 25 restore restore VB cord-287123-ldkuwcc7 383 26 the the DT cord-287123-ldkuwcc7 383 27 potency potency NN cord-287123-ldkuwcc7 383 28 of of IN cord-287123-ldkuwcc7 383 29 fMLF fmlf NN cord-287123-ldkuwcc7 383 30 to to IN cord-287123-ldkuwcc7 383 31 the the DT cord-287123-ldkuwcc7 383 32 level level NN cord-287123-ldkuwcc7 383 33 in in IN cord-287123-ldkuwcc7 383 34 FPR1 FPR1 NNP cord-287123-ldkuwcc7 383 35 [ [ -LRB- cord-287123-ldkuwcc7 383 36 96 96 CD cord-287123-ldkuwcc7 383 37 ] ] -RRB- cord-287123-ldkuwcc7 383 38 . . . cord-287123-ldkuwcc7 384 1 Studies study NNS cord-287123-ldkuwcc7 384 2 have have VBP cord-287123-ldkuwcc7 384 3 also also RB cord-287123-ldkuwcc7 384 4 shown show VBN cord-287123-ldkuwcc7 384 5 that that IN cord-287123-ldkuwcc7 384 6 longer long JJR cord-287123-ldkuwcc7 384 7 formyl formyl NNP cord-287123-ldkuwcc7 384 8 peptides peptide NNS cord-287123-ldkuwcc7 384 9 with with IN cord-287123-ldkuwcc7 384 10 α α NN cord-287123-ldkuwcc7 384 11 - - HYPH cord-287123-ldkuwcc7 384 12 helical helical JJ cord-287123-ldkuwcc7 384 13 and and CC cord-287123-ldkuwcc7 384 14 amphipathic amphipathic NNP cord-287123-ldkuwcc7 384 15 properties property NNS cord-287123-ldkuwcc7 384 16 favor favor VBP cord-287123-ldkuwcc7 384 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 384 18 over over IN cord-287123-ldkuwcc7 384 19 FPR1 FPR1 NNP cord-287123-ldkuwcc7 384 20 [ [ -LRB- cord-287123-ldkuwcc7 384 21 52 52 CD cord-287123-ldkuwcc7 384 22 , , , cord-287123-ldkuwcc7 384 23 216 216 CD cord-287123-ldkuwcc7 384 24 , , , cord-287123-ldkuwcc7 384 25 217 217 CD cord-287123-ldkuwcc7 384 26 ] ] -RRB- cord-287123-ldkuwcc7 384 27 . . . cord-287123-ldkuwcc7 385 1 A a DT cord-287123-ldkuwcc7 385 2 simple simple JJ cord-287123-ldkuwcc7 385 3 explanation explanation NN cord-287123-ldkuwcc7 385 4 is be VBZ cord-287123-ldkuwcc7 385 5 that that IN cord-287123-ldkuwcc7 385 6 the the DT cord-287123-ldkuwcc7 385 7 binding bind VBG cord-287123-ldkuwcc7 385 8 pocket pocket NN cord-287123-ldkuwcc7 385 9 of of IN cord-287123-ldkuwcc7 385 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 385 11 is be VBZ cord-287123-ldkuwcc7 385 12 larger large JJR cord-287123-ldkuwcc7 385 13 and and CC cord-287123-ldkuwcc7 385 14 deeper deep JJR cord-287123-ldkuwcc7 385 15 than than IN cord-287123-ldkuwcc7 385 16 the the DT cord-287123-ldkuwcc7 385 17 relatively relatively RB cord-287123-ldkuwcc7 385 18 shallow shallow JJ cord-287123-ldkuwcc7 385 19 and and CC cord-287123-ldkuwcc7 385 20 narrow narrow JJ cord-287123-ldkuwcc7 385 21 one one CD cord-287123-ldkuwcc7 385 22 in in IN cord-287123-ldkuwcc7 385 23 FPR1 FPR1 NNP cord-287123-ldkuwcc7 385 24 , , , cord-287123-ldkuwcc7 385 25 thus thus RB cord-287123-ldkuwcc7 385 26 providing provide VBG cord-287123-ldkuwcc7 385 27 an an DT cord-287123-ldkuwcc7 385 28 added add VBN cord-287123-ldkuwcc7 385 29 advantage advantage NN cord-287123-ldkuwcc7 385 30 in in IN cord-287123-ldkuwcc7 385 31 accommodating accommodate VBG cord-287123-ldkuwcc7 385 32 longer long JJR cord-287123-ldkuwcc7 385 33 peptides peptide NNS cord-287123-ldkuwcc7 385 34 . . . cord-287123-ldkuwcc7 386 1 To to TO cord-287123-ldkuwcc7 386 2 understand understand VB cord-287123-ldkuwcc7 386 3 the the DT cord-287123-ldkuwcc7 386 4 structural structural JJ cord-287123-ldkuwcc7 386 5 basis basis NN cord-287123-ldkuwcc7 386 6 for for IN cord-287123-ldkuwcc7 386 7 the the DT cord-287123-ldkuwcc7 386 8 selective selective JJ cord-287123-ldkuwcc7 386 9 activation activation NN cord-287123-ldkuwcc7 386 10 of of IN cord-287123-ldkuwcc7 386 11 FPR2 FPR2 NNP cord-287123-ldkuwcc7 386 12 by by IN cord-287123-ldkuwcc7 386 13 pro pro JJ cord-287123-ldkuwcc7 386 14 - - JJ cord-287123-ldkuwcc7 386 15 resolving resolving JJ cord-287123-ldkuwcc7 386 16 modulators modulator NNS cord-287123-ldkuwcc7 386 17 , , , cord-287123-ldkuwcc7 386 18 chimeric chimeric JJ cord-287123-ldkuwcc7 386 19 receptors receptor NNS cord-287123-ldkuwcc7 386 20 were be VBD cord-287123-ldkuwcc7 386 21 constructed construct VBN cord-287123-ldkuwcc7 386 22 between between IN cord-287123-ldkuwcc7 386 23 FPR2 FPR2 NNP cord-287123-ldkuwcc7 386 24 and and CC cord-287123-ldkuwcc7 386 25 other other JJ cord-287123-ldkuwcc7 386 26 receptors receptor NNS cord-287123-ldkuwcc7 386 27 , , , cord-287123-ldkuwcc7 386 28 including include VBG cord-287123-ldkuwcc7 386 29 FPR1 FPR1 NNP cord-287123-ldkuwcc7 386 30 and and CC cord-287123-ldkuwcc7 386 31 BLT1 BLT1 NNP cord-287123-ldkuwcc7 386 32 . . . cord-287123-ldkuwcc7 387 1 The the DT cord-287123-ldkuwcc7 387 2 study study NN cord-287123-ldkuwcc7 387 3 using use VBG cord-287123-ldkuwcc7 387 4 these these DT cord-287123-ldkuwcc7 387 5 chimeras chimera NNS cord-287123-ldkuwcc7 387 6 demonstrated demonstrate VBD cord-287123-ldkuwcc7 387 7 that that IN cord-287123-ldkuwcc7 387 8 TM7 TM7 NNP cord-287123-ldkuwcc7 387 9 and and CC cord-287123-ldkuwcc7 387 10 adjacent adjacent JJ cord-287123-ldkuwcc7 387 11 regions region NNS cord-287123-ldkuwcc7 387 12 of of IN cord-287123-ldkuwcc7 387 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 387 14 are be VBP cord-287123-ldkuwcc7 387 15 essential essential JJ cord-287123-ldkuwcc7 387 16 for for IN cord-287123-ldkuwcc7 387 17 the the DT cord-287123-ldkuwcc7 387 18 recognition recognition NN cord-287123-ldkuwcc7 387 19 of of IN cord-287123-ldkuwcc7 387 20 LXA4 LXA4 NNP cord-287123-ldkuwcc7 387 21 . . . cord-287123-ldkuwcc7 388 1 In in IN cord-287123-ldkuwcc7 388 2 contrast contrast NN cord-287123-ldkuwcc7 388 3 , , , cord-287123-ldkuwcc7 388 4 the the DT cord-287123-ldkuwcc7 388 5 extracellular extracellular JJ cord-287123-ldkuwcc7 388 6 loops loop NNS cord-287123-ldkuwcc7 388 7 were be VBD cord-287123-ldkuwcc7 388 8 required require VBN cord-287123-ldkuwcc7 388 9 for for IN cord-287123-ldkuwcc7 388 10 high high JJ cord-287123-ldkuwcc7 388 11 affinity affinity NN cord-287123-ldkuwcc7 388 12 binding binding NN cord-287123-ldkuwcc7 388 13 for for IN cord-287123-ldkuwcc7 388 14 pro pro JJ cord-287123-ldkuwcc7 388 15 - - JJ cord-287123-ldkuwcc7 388 16 inflammatory inflammatory JJ cord-287123-ldkuwcc7 388 17 peptide peptide NN cord-287123-ldkuwcc7 388 18 agonists agonist NNS cord-287123-ldkuwcc7 388 19 such such JJ cord-287123-ldkuwcc7 388 20 as as IN cord-287123-ldkuwcc7 388 21 MMK1 MMK1 NNP cord-287123-ldkuwcc7 388 22 and and CC cord-287123-ldkuwcc7 388 23 the the DT cord-287123-ldkuwcc7 388 24 MHC MHC NNP cord-287123-ldkuwcc7 388 25 peptides peptide NNS cord-287123-ldkuwcc7 388 26 . . . cord-287123-ldkuwcc7 389 1 In in IN cord-287123-ldkuwcc7 389 2 addition addition NN cord-287123-ldkuwcc7 389 3 , , , cord-287123-ldkuwcc7 389 4 conserved conserved JJ cord-287123-ldkuwcc7 389 5 N n CD cord-287123-ldkuwcc7 389 6 - - HYPH cord-287123-ldkuwcc7 389 7 glycosylation glycosylation NN cord-287123-ldkuwcc7 389 8 sites site NNS cord-287123-ldkuwcc7 389 9 in in IN cord-287123-ldkuwcc7 389 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 389 11 ( ( -LRB- cord-287123-ldkuwcc7 389 12 Asn Asn NNP cord-287123-ldkuwcc7 389 13 4 4 CD cord-287123-ldkuwcc7 389 14 and and CC cord-287123-ldkuwcc7 389 15 Asn Asn NNP cord-287123-ldkuwcc7 389 16 179 179 CD cord-287123-ldkuwcc7 389 17 ) ) -RRB- cord-287123-ldkuwcc7 389 18 were be VBD cord-287123-ldkuwcc7 389 19 also also RB cord-287123-ldkuwcc7 389 20 implicated implicate VBN cord-287123-ldkuwcc7 389 21 in in IN cord-287123-ldkuwcc7 389 22 the the DT cord-287123-ldkuwcc7 389 23 interaction interaction NN cord-287123-ldkuwcc7 389 24 with with IN cord-287123-ldkuwcc7 389 25 these these DT cord-287123-ldkuwcc7 389 26 peptides peptide NNS cord-287123-ldkuwcc7 389 27 but but CC cord-287123-ldkuwcc7 389 28 not not RB cord-287123-ldkuwcc7 389 29 with with IN cord-287123-ldkuwcc7 389 30 LXA4 LXA4 NNP cord-287123-ldkuwcc7 389 31 [ [ -LRB- cord-287123-ldkuwcc7 389 32 2 2 CD cord-287123-ldkuwcc7 389 33 , , , cord-287123-ldkuwcc7 389 34 218 218 CD cord-287123-ldkuwcc7 389 35 ] ] -RRB- cord-287123-ldkuwcc7 389 36 . . . cord-287123-ldkuwcc7 390 1 In in IN cord-287123-ldkuwcc7 390 2 another another DT cord-287123-ldkuwcc7 390 3 study study NN cord-287123-ldkuwcc7 390 4 , , , cord-287123-ldkuwcc7 390 5 a a DT cord-287123-ldkuwcc7 390 6 computational computational JJ cord-287123-ldkuwcc7 390 7 model model NN cord-287123-ldkuwcc7 390 8 of of IN cord-287123-ldkuwcc7 390 9 FPR1-annexin FPR1-annexin NNP cord-287123-ldkuwcc7 390 10 peptide peptide NN cord-287123-ldkuwcc7 390 11 interaction interaction NN cord-287123-ldkuwcc7 390 12 was be VBD cord-287123-ldkuwcc7 390 13 built build VBN cord-287123-ldkuwcc7 390 14 and and CC cord-287123-ldkuwcc7 390 15 it -PRON- PRP cord-287123-ldkuwcc7 390 16 suggested suggest VBD cord-287123-ldkuwcc7 390 17 that that IN cord-287123-ldkuwcc7 390 18 the the DT cord-287123-ldkuwcc7 390 19 transmembrane transmembrane NN cord-287123-ldkuwcc7 390 20 portions portion NNS cord-287123-ldkuwcc7 390 21 ( ( -LRB- cord-287123-ldkuwcc7 390 22 TM2 TM2 NNP cord-287123-ldkuwcc7 390 23 , , , cord-287123-ldkuwcc7 390 24 TM5 TM5 NNP cord-287123-ldkuwcc7 390 25 , , , cord-287123-ldkuwcc7 390 26 TM6 tm6 NN cord-287123-ldkuwcc7 390 27 , , , cord-287123-ldkuwcc7 390 28 TM7 TM7 NNP cord-287123-ldkuwcc7 390 29 ) ) -RRB- cord-287123-ldkuwcc7 390 30 of of IN cord-287123-ldkuwcc7 390 31 the the DT cord-287123-ldkuwcc7 390 32 binding bind VBG cord-287123-ldkuwcc7 390 33 pocket pocket NN cord-287123-ldkuwcc7 390 34 of of IN cord-287123-ldkuwcc7 390 35 FPR1 FPR1 NNP cord-287123-ldkuwcc7 390 36 is be VBZ cord-287123-ldkuwcc7 390 37 important important JJ cord-287123-ldkuwcc7 390 38 to to TO cord-287123-ldkuwcc7 390 39 optimal optimal JJ cord-287123-ldkuwcc7 390 40 binding binding NN cord-287123-ldkuwcc7 390 41 of of IN cord-287123-ldkuwcc7 390 42 the the DT cord-287123-ldkuwcc7 390 43 N n CD cord-287123-ldkuwcc7 390 44 - - HYPH cord-287123-ldkuwcc7 390 45 terminal terminal NN cord-287123-ldkuwcc7 390 46 residue residue NN cord-287123-ldkuwcc7 390 47 in in IN cord-287123-ldkuwcc7 390 48 Ac-9 Ac-9 NNP cord-287123-ldkuwcc7 390 49 QAWF QAWF NNP cord-287123-ldkuwcc7 390 50 12 12 CD cord-287123-ldkuwcc7 390 51 , , , cord-287123-ldkuwcc7 390 52 the the DT cord-287123-ldkuwcc7 390 53 core core NN cord-287123-ldkuwcc7 390 54 structure structure NN cord-287123-ldkuwcc7 390 55 of of IN cord-287123-ldkuwcc7 390 56 active active JJ cord-287123-ldkuwcc7 390 57 annexin annexin NN cord-287123-ldkuwcc7 390 58 peptides peptide NNS cord-287123-ldkuwcc7 390 59 [ [ -LRB- cord-287123-ldkuwcc7 390 60 219 219 CD cord-287123-ldkuwcc7 390 61 ] ] -RRB- cord-287123-ldkuwcc7 390 62 . . . cord-287123-ldkuwcc7 391 1 Using use VBG cord-287123-ldkuwcc7 391 2 the the DT cord-287123-ldkuwcc7 391 3 same same JJ cord-287123-ldkuwcc7 391 4 set set NN cord-287123-ldkuwcc7 391 5 of of IN cord-287123-ldkuwcc7 391 6 chimeric chimeric JJ cord-287123-ldkuwcc7 391 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 391 8 / / SYM cord-287123-ldkuwcc7 391 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 391 10 receptor receptor NN cord-287123-ldkuwcc7 391 11 [ [ -LRB- cord-287123-ldkuwcc7 391 12 206 206 CD cord-287123-ldkuwcc7 391 13 ] ] -RRB- cord-287123-ldkuwcc7 391 14 stably stably RB cord-287123-ldkuwcc7 391 15 expressed express VBD cord-287123-ldkuwcc7 391 16 in in IN cord-287123-ldkuwcc7 391 17 HEK293 HEK293 NNP cord-287123-ldkuwcc7 391 18 cells cell NNS cord-287123-ldkuwcc7 391 19 [ [ -LRB- cord-287123-ldkuwcc7 391 20 208 208 CD cord-287123-ldkuwcc7 391 21 ] ] -RRB- cord-287123-ldkuwcc7 391 22 , , , cord-287123-ldkuwcc7 391 23 the the DT cord-287123-ldkuwcc7 391 24 N n CD cord-287123-ldkuwcc7 391 25 - - HYPH cord-287123-ldkuwcc7 391 26 terminal terminal NN cord-287123-ldkuwcc7 391 27 region region NN cord-287123-ldkuwcc7 391 28 and and CC cord-287123-ldkuwcc7 391 29 the the DT cord-287123-ldkuwcc7 391 30 second second JJ cord-287123-ldkuwcc7 391 31 extracellular extracellular JJ cord-287123-ldkuwcc7 391 32 loop loop NN cord-287123-ldkuwcc7 391 33 of of IN cord-287123-ldkuwcc7 391 34 FPR2 FPR2 NNP cord-287123-ldkuwcc7 391 35 were be VBD cord-287123-ldkuwcc7 391 36 identified identify VBN cord-287123-ldkuwcc7 391 37 as as IN cord-287123-ldkuwcc7 391 38 required require VBN cord-287123-ldkuwcc7 391 39 for for IN cord-287123-ldkuwcc7 392 1 annexin annexin NNP cord-287123-ldkuwcc7 392 2 A1-mediated a1-mediate VBD cord-287123-ldkuwcc7 392 3 signaling signal VBG cord-287123-ldkuwcc7 392 4 [ [ -LRB- cord-287123-ldkuwcc7 392 5 220 220 CD cord-287123-ldkuwcc7 392 6 ] ] -RRB- cord-287123-ldkuwcc7 392 7 . . . cord-287123-ldkuwcc7 393 1 Chimeric chimeric JJ cord-287123-ldkuwcc7 393 2 receptors receptor NNS cord-287123-ldkuwcc7 393 3 were be VBD cord-287123-ldkuwcc7 393 4 also also RB cord-287123-ldkuwcc7 393 5 constructed construct VBN cord-287123-ldkuwcc7 393 6 to to TO cord-287123-ldkuwcc7 393 7 dissect dissect VB cord-287123-ldkuwcc7 393 8 the the DT cord-287123-ldkuwcc7 393 9 mechanisms mechanism NNS cord-287123-ldkuwcc7 393 10 of of IN cord-287123-ldkuwcc7 393 11 action action NN cord-287123-ldkuwcc7 393 12 by by IN cord-287123-ldkuwcc7 393 13 which which WDT cord-287123-ldkuwcc7 393 14 cell cell NN cord-287123-ldkuwcc7 393 15 - - HYPH cord-287123-ldkuwcc7 393 16 penetrating penetrate VBG cord-287123-ldkuwcc7 393 17 lipopeptides lipopeptide NNS cord-287123-ldkuwcc7 394 1 ( ( -LRB- cord-287123-ldkuwcc7 394 2 e.g. e.g. RB cord-287123-ldkuwcc7 394 3 , , , cord-287123-ldkuwcc7 394 4 pepducins pepducin NNS cord-287123-ldkuwcc7 394 5 and and CC cord-287123-ldkuwcc7 394 6 PBP10 PBP10 NNP cord-287123-ldkuwcc7 394 7 ) ) -RRB- cord-287123-ldkuwcc7 394 8 use use VBP cord-287123-ldkuwcc7 394 9 unconventional unconventional JJ cord-287123-ldkuwcc7 394 10 access access NN cord-287123-ldkuwcc7 394 11 to to TO cord-287123-ldkuwcc7 394 12 modulate modulate VB cord-287123-ldkuwcc7 394 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 394 14 . . . cord-287123-ldkuwcc7 395 1 It -PRON- PRP cord-287123-ldkuwcc7 395 2 was be VBD cord-287123-ldkuwcc7 395 3 suggested suggest VBN cord-287123-ldkuwcc7 395 4 that that IN cord-287123-ldkuwcc7 395 5 the the DT cord-287123-ldkuwcc7 395 6 pepducins pepducins NNP cord-287123-ldkuwcc7 395 7 F2Pal16 F2Pal16 NNP cord-287123-ldkuwcc7 395 8 and and CC cord-287123-ldkuwcc7 395 9 F2Pal10 F2Pal10 NNP cord-287123-ldkuwcc7 395 10 act act VBP cord-287123-ldkuwcc7 395 11 primarily primarily RB cord-287123-ldkuwcc7 395 12 through through IN cord-287123-ldkuwcc7 395 13 the the DT cord-287123-ldkuwcc7 395 14 third third JJ cord-287123-ldkuwcc7 395 15 intracellular intracellular JJ cord-287123-ldkuwcc7 395 16 loop loop NN cord-287123-ldkuwcc7 395 17 of of IN cord-287123-ldkuwcc7 395 18 FPR2 FPR2 NNP cord-287123-ldkuwcc7 395 19 . . . cord-287123-ldkuwcc7 396 1 The the DT cord-287123-ldkuwcc7 396 2 third third JJ cord-287123-ldkuwcc7 396 3 intracellular intracellular JJ cord-287123-ldkuwcc7 396 4 loops loop NNS cord-287123-ldkuwcc7 396 5 of of IN cord-287123-ldkuwcc7 396 6 FPR1 FPR1 NNP cord-287123-ldkuwcc7 396 7 and and CC cord-287123-ldkuwcc7 396 8 FPR2 FPR2 NNP cord-287123-ldkuwcc7 396 9 differ differ VBP cord-287123-ldkuwcc7 396 10 in in IN cord-287123-ldkuwcc7 396 11 only only RB cord-287123-ldkuwcc7 396 12 two two CD cord-287123-ldkuwcc7 396 13 amino amino NN cord-287123-ldkuwcc7 396 14 acids acid NNS cord-287123-ldkuwcc7 396 15 . . . cord-287123-ldkuwcc7 397 1 However however RB cord-287123-ldkuwcc7 397 2 , , , cord-287123-ldkuwcc7 397 3 a a DT cord-287123-ldkuwcc7 397 4 substitution substitution NN cord-287123-ldkuwcc7 397 5 of of IN cord-287123-ldkuwcc7 397 6 these these DT cord-287123-ldkuwcc7 397 7 amino amino NN cord-287123-ldkuwcc7 397 8 acids acid NNS cord-287123-ldkuwcc7 397 9 from from IN cord-287123-ldkuwcc7 397 10 FPR1 FPR1 NNP cord-287123-ldkuwcc7 397 11 to to IN cord-287123-ldkuwcc7 397 12 FPR2 FPR2 NNP cord-287123-ldkuwcc7 397 13 did do VBD cord-287123-ldkuwcc7 397 14 not not RB cord-287123-ldkuwcc7 397 15 affect affect VB cord-287123-ldkuwcc7 397 16 the the DT cord-287123-ldkuwcc7 397 17 selectivity selectivity NN cord-287123-ldkuwcc7 397 18 of of IN cord-287123-ldkuwcc7 397 19 these these DT cord-287123-ldkuwcc7 397 20 pepducins pepducin NNS cord-287123-ldkuwcc7 397 21 [ [ -LRB- cord-287123-ldkuwcc7 397 22 73 73 CD cord-287123-ldkuwcc7 397 23 ] ] -RRB- cord-287123-ldkuwcc7 397 24 . . . cord-287123-ldkuwcc7 398 1 Another another DT cord-287123-ldkuwcc7 398 2 study study NN cord-287123-ldkuwcc7 398 3 focused focus VBD cord-287123-ldkuwcc7 398 4 on on IN cord-287123-ldkuwcc7 398 5 PBP10 PBP10 NNP cord-287123-ldkuwcc7 398 6 , , , cord-287123-ldkuwcc7 398 7 an an DT cord-287123-ldkuwcc7 398 8 antagonist antagonist NN cord-287123-ldkuwcc7 398 9 against against IN cord-287123-ldkuwcc7 398 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 398 11 agonists agonist NNS cord-287123-ldkuwcc7 398 12 , , , cord-287123-ldkuwcc7 398 13 suggested suggest VBD cord-287123-ldkuwcc7 398 14 that that IN cord-287123-ldkuwcc7 398 15 neither neither CC cord-287123-ldkuwcc7 398 16 the the DT cord-287123-ldkuwcc7 398 17 third third JJ cord-287123-ldkuwcc7 398 18 intracellular intracellular JJ cord-287123-ldkuwcc7 398 19 loop loop NN cord-287123-ldkuwcc7 398 20 nor nor CC cord-287123-ldkuwcc7 398 21 the the DT cord-287123-ldkuwcc7 398 22 presumed presume VBN cord-287123-ldkuwcc7 398 23 signaling signal VBG cord-287123-ldkuwcc7 398 24 cytoplasmic cytoplasmic JJ cord-287123-ldkuwcc7 398 25 tail tail NN cord-287123-ldkuwcc7 398 26 of of IN cord-287123-ldkuwcc7 398 27 FPR2 FPR2 NNP cord-287123-ldkuwcc7 398 28 alone alone RB cord-287123-ldkuwcc7 398 29 is be VBZ cord-287123-ldkuwcc7 398 30 responsible responsible JJ cord-287123-ldkuwcc7 398 31 for for IN cord-287123-ldkuwcc7 398 32 the the DT cord-287123-ldkuwcc7 398 33 specific specific JJ cord-287123-ldkuwcc7 398 34 inhibition inhibition NN cord-287123-ldkuwcc7 398 35 of of IN cord-287123-ldkuwcc7 398 36 PBP10 PBP10 NNPS cord-287123-ldkuwcc7 398 37 [ [ -LRB- cord-287123-ldkuwcc7 398 38 90 90 CD cord-287123-ldkuwcc7 398 39 ] ] -RRB- cord-287123-ldkuwcc7 398 40 . . . cord-287123-ldkuwcc7 399 1 Clearly clearly RB cord-287123-ldkuwcc7 399 2 , , , cord-287123-ldkuwcc7 399 3 the the DT cord-287123-ldkuwcc7 399 4 current current JJ cord-287123-ldkuwcc7 399 5 knowledge knowledge NN cord-287123-ldkuwcc7 399 6 on on IN cord-287123-ldkuwcc7 399 7 the the DT cord-287123-ldkuwcc7 399 8 action action NN cord-287123-ldkuwcc7 399 9 mode mode NN cord-287123-ldkuwcc7 399 10 and and CC cord-287123-ldkuwcc7 399 11 binding bind VBG cord-287123-ldkuwcc7 399 12 sites site NNS cord-287123-ldkuwcc7 399 13 of of IN cord-287123-ldkuwcc7 399 14 these these DT cord-287123-ldkuwcc7 399 15 lipopeptides lipopeptide NNS cord-287123-ldkuwcc7 399 16 is be VBZ cord-287123-ldkuwcc7 399 17 still still RB cord-287123-ldkuwcc7 399 18 very very RB cord-287123-ldkuwcc7 399 19 limited limited JJ cord-287123-ldkuwcc7 399 20 . . . cord-287123-ldkuwcc7 400 1 Perhaps perhaps RB cord-287123-ldkuwcc7 400 2 new new JJ cord-287123-ldkuwcc7 400 3 strategies strategy NNS cord-287123-ldkuwcc7 400 4 should should MD cord-287123-ldkuwcc7 400 5 be be VB cord-287123-ldkuwcc7 400 6 exploited exploit VBN cord-287123-ldkuwcc7 400 7 to to TO cord-287123-ldkuwcc7 400 8 understand understand VB cord-287123-ldkuwcc7 400 9 the the DT cord-287123-ldkuwcc7 400 10 structure structure NN cord-287123-ldkuwcc7 400 11 - - HYPH cord-287123-ldkuwcc7 400 12 function function NN cord-287123-ldkuwcc7 400 13 relationship relationship NN cord-287123-ldkuwcc7 400 14 of of IN cord-287123-ldkuwcc7 400 15 FPR FPR NNP cord-287123-ldkuwcc7 400 16 in in IN cord-287123-ldkuwcc7 400 17 association association NN cord-287123-ldkuwcc7 400 18 with with IN cord-287123-ldkuwcc7 400 19 these these DT cord-287123-ldkuwcc7 400 20 allosteric allosteric JJ cord-287123-ldkuwcc7 400 21 modulators modulator NNS cord-287123-ldkuwcc7 400 22 before before IN cord-287123-ldkuwcc7 400 23 crystal crystal NN cord-287123-ldkuwcc7 400 24 structures structure NNS cord-287123-ldkuwcc7 400 25 become become VBP cord-287123-ldkuwcc7 400 26 available available JJ cord-287123-ldkuwcc7 400 27 . . . cord-287123-ldkuwcc7 401 1 the the DT cord-287123-ldkuwcc7 401 2 relatively relatively RB cord-287123-ldkuwcc7 401 3 shallow shallow JJ cord-287123-ldkuwcc7 401 4 and and CC cord-287123-ldkuwcc7 401 5 narrow narrow JJ cord-287123-ldkuwcc7 401 6 one one CD cord-287123-ldkuwcc7 401 7 in in IN cord-287123-ldkuwcc7 401 8 FPR1 FPR1 NNP cord-287123-ldkuwcc7 401 9 , , , cord-287123-ldkuwcc7 401 10 thus thus RB cord-287123-ldkuwcc7 401 11 providing provide VBG cord-287123-ldkuwcc7 401 12 an an DT cord-287123-ldkuwcc7 401 13 added add VBN cord-287123-ldkuwcc7 401 14 advantage advantage NN cord-287123-ldkuwcc7 401 15 in in IN cord-287123-ldkuwcc7 401 16 accommodating accommodate VBG cord-287123-ldkuwcc7 401 17 longer long JJR cord-287123-ldkuwcc7 401 18 peptides peptide NNS cord-287123-ldkuwcc7 401 19 . . . cord-287123-ldkuwcc7 402 1 To to TO cord-287123-ldkuwcc7 402 2 understand understand VB cord-287123-ldkuwcc7 402 3 the the DT cord-287123-ldkuwcc7 402 4 structural structural JJ cord-287123-ldkuwcc7 402 5 basis basis NN cord-287123-ldkuwcc7 402 6 for for IN cord-287123-ldkuwcc7 402 7 the the DT cord-287123-ldkuwcc7 402 8 selective selective JJ cord-287123-ldkuwcc7 402 9 activation activation NN cord-287123-ldkuwcc7 402 10 of of IN cord-287123-ldkuwcc7 402 11 FPR2 FPR2 NNP cord-287123-ldkuwcc7 402 12 by by IN cord-287123-ldkuwcc7 402 13 pro pro JJ cord-287123-ldkuwcc7 402 14 - - JJ cord-287123-ldkuwcc7 402 15 resolving resolving JJ cord-287123-ldkuwcc7 402 16 modulators modulator NNS cord-287123-ldkuwcc7 402 17 , , , cord-287123-ldkuwcc7 402 18 chimeric chimeric JJ cord-287123-ldkuwcc7 402 19 receptors receptor NNS cord-287123-ldkuwcc7 402 20 were be VBD cord-287123-ldkuwcc7 402 21 constructed construct VBN cord-287123-ldkuwcc7 402 22 between between IN cord-287123-ldkuwcc7 402 23 FPR2 FPR2 NNP cord-287123-ldkuwcc7 402 24 and and CC cord-287123-ldkuwcc7 402 25 other other JJ cord-287123-ldkuwcc7 402 26 receptors receptor NNS cord-287123-ldkuwcc7 402 27 , , , cord-287123-ldkuwcc7 402 28 including include VBG cord-287123-ldkuwcc7 402 29 FPR1 FPR1 NNP cord-287123-ldkuwcc7 402 30 and and CC cord-287123-ldkuwcc7 402 31 BLT1 BLT1 NNP cord-287123-ldkuwcc7 402 32 . . . cord-287123-ldkuwcc7 403 1 The the DT cord-287123-ldkuwcc7 403 2 study study NN cord-287123-ldkuwcc7 403 3 using use VBG cord-287123-ldkuwcc7 403 4 these these DT cord-287123-ldkuwcc7 403 5 chimeras chimera NNS cord-287123-ldkuwcc7 403 6 demonstrated demonstrate VBD cord-287123-ldkuwcc7 403 7 that that IN cord-287123-ldkuwcc7 403 8 TM7 TM7 NNP cord-287123-ldkuwcc7 403 9 and and CC cord-287123-ldkuwcc7 403 10 adjacent adjacent JJ cord-287123-ldkuwcc7 403 11 regions region NNS cord-287123-ldkuwcc7 403 12 of of IN cord-287123-ldkuwcc7 403 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 403 14 are be VBP cord-287123-ldkuwcc7 403 15 essential essential JJ cord-287123-ldkuwcc7 403 16 for for IN cord-287123-ldkuwcc7 403 17 the the DT cord-287123-ldkuwcc7 403 18 recognition recognition NN cord-287123-ldkuwcc7 403 19 of of IN cord-287123-ldkuwcc7 403 20 LXA4 LXA4 NNP cord-287123-ldkuwcc7 403 21 . . . cord-287123-ldkuwcc7 404 1 In in IN cord-287123-ldkuwcc7 404 2 contrast contrast NN cord-287123-ldkuwcc7 404 3 , , , cord-287123-ldkuwcc7 404 4 the the DT cord-287123-ldkuwcc7 404 5 extracellular extracellular JJ cord-287123-ldkuwcc7 404 6 loops loop NNS cord-287123-ldkuwcc7 404 7 were be VBD cord-287123-ldkuwcc7 404 8 required require VBN cord-287123-ldkuwcc7 404 9 for for IN cord-287123-ldkuwcc7 404 10 high high JJ cord-287123-ldkuwcc7 404 11 affinity affinity NN cord-287123-ldkuwcc7 404 12 binding binding NN cord-287123-ldkuwcc7 404 13 for for IN cord-287123-ldkuwcc7 404 14 pro pro JJ cord-287123-ldkuwcc7 404 15 - - JJ cord-287123-ldkuwcc7 404 16 inflammatory inflammatory JJ cord-287123-ldkuwcc7 404 17 peptide peptide NN cord-287123-ldkuwcc7 404 18 agonists agonist NNS cord-287123-ldkuwcc7 404 19 such such JJ cord-287123-ldkuwcc7 404 20 as as IN cord-287123-ldkuwcc7 404 21 MMK1 MMK1 NNP cord-287123-ldkuwcc7 404 22 and and CC cord-287123-ldkuwcc7 404 23 the the DT cord-287123-ldkuwcc7 404 24 MHC MHC NNP cord-287123-ldkuwcc7 404 25 peptides peptide NNS cord-287123-ldkuwcc7 404 26 . . . cord-287123-ldkuwcc7 405 1 In in IN cord-287123-ldkuwcc7 405 2 addition addition NN cord-287123-ldkuwcc7 405 3 , , , cord-287123-ldkuwcc7 405 4 conserved conserved JJ cord-287123-ldkuwcc7 405 5 N n CD cord-287123-ldkuwcc7 405 6 - - HYPH cord-287123-ldkuwcc7 405 7 glycosylation glycosylation NN cord-287123-ldkuwcc7 405 8 sites site NNS cord-287123-ldkuwcc7 405 9 in in IN cord-287123-ldkuwcc7 405 10 FPR2 FPR2 NNP cord-287123-ldkuwcc7 405 11 ( ( -LRB- cord-287123-ldkuwcc7 405 12 Asn Asn NNP cord-287123-ldkuwcc7 405 13 4 4 CD cord-287123-ldkuwcc7 405 14 and and CC cord-287123-ldkuwcc7 405 15 Asn Asn NNP cord-287123-ldkuwcc7 405 16 179 179 CD cord-287123-ldkuwcc7 405 17 ) ) -RRB- cord-287123-ldkuwcc7 405 18 were be VBD cord-287123-ldkuwcc7 405 19 also also RB cord-287123-ldkuwcc7 405 20 implicated implicate VBN cord-287123-ldkuwcc7 405 21 in in IN cord-287123-ldkuwcc7 405 22 the the DT cord-287123-ldkuwcc7 405 23 interaction interaction NN cord-287123-ldkuwcc7 405 24 with with IN cord-287123-ldkuwcc7 405 25 these these DT cord-287123-ldkuwcc7 405 26 peptides peptide NNS cord-287123-ldkuwcc7 405 27 but but CC cord-287123-ldkuwcc7 405 28 not not RB cord-287123-ldkuwcc7 405 29 with with IN cord-287123-ldkuwcc7 405 30 LXA4 LXA4 NNP cord-287123-ldkuwcc7 405 31 [ [ -LRB- cord-287123-ldkuwcc7 405 32 2 2 CD cord-287123-ldkuwcc7 405 33 , , , cord-287123-ldkuwcc7 405 34 218 218 CD cord-287123-ldkuwcc7 405 35 ] ] -RRB- cord-287123-ldkuwcc7 405 36 . . . cord-287123-ldkuwcc7 406 1 In in IN cord-287123-ldkuwcc7 406 2 another another DT cord-287123-ldkuwcc7 406 3 study study NN cord-287123-ldkuwcc7 406 4 , , , cord-287123-ldkuwcc7 406 5 a a DT cord-287123-ldkuwcc7 406 6 computational computational JJ cord-287123-ldkuwcc7 406 7 model model NN cord-287123-ldkuwcc7 406 8 of of IN cord-287123-ldkuwcc7 406 9 FPR1-annexin FPR1-annexin NNP cord-287123-ldkuwcc7 406 10 peptide peptide NN cord-287123-ldkuwcc7 406 11 interaction interaction NN cord-287123-ldkuwcc7 406 12 was be VBD cord-287123-ldkuwcc7 406 13 built build VBN cord-287123-ldkuwcc7 406 14 and and CC cord-287123-ldkuwcc7 406 15 it -PRON- PRP cord-287123-ldkuwcc7 406 16 suggested suggest VBD cord-287123-ldkuwcc7 406 17 that that IN cord-287123-ldkuwcc7 406 18 the the DT cord-287123-ldkuwcc7 406 19 transmembrane transmembrane NN cord-287123-ldkuwcc7 406 20 portions portion NNS cord-287123-ldkuwcc7 406 21 ( ( -LRB- cord-287123-ldkuwcc7 406 22 TM2 TM2 NNP cord-287123-ldkuwcc7 406 23 , , , cord-287123-ldkuwcc7 406 24 TM5 TM5 NNP cord-287123-ldkuwcc7 406 25 , , , cord-287123-ldkuwcc7 406 26 TM6 tm6 NN cord-287123-ldkuwcc7 406 27 , , , cord-287123-ldkuwcc7 406 28 TM7 TM7 NNP cord-287123-ldkuwcc7 406 29 ) ) -RRB- cord-287123-ldkuwcc7 406 30 of of IN cord-287123-ldkuwcc7 406 31 the the DT cord-287123-ldkuwcc7 406 32 binding bind VBG cord-287123-ldkuwcc7 406 33 pocket pocket NN cord-287123-ldkuwcc7 406 34 of of IN cord-287123-ldkuwcc7 406 35 FPR1 FPR1 NNP cord-287123-ldkuwcc7 406 36 is be VBZ cord-287123-ldkuwcc7 406 37 important important JJ cord-287123-ldkuwcc7 406 38 to to TO cord-287123-ldkuwcc7 406 39 optimal optimal JJ cord-287123-ldkuwcc7 406 40 binding binding NN cord-287123-ldkuwcc7 406 41 of of IN cord-287123-ldkuwcc7 406 42 the the DT cord-287123-ldkuwcc7 406 43 N n CD cord-287123-ldkuwcc7 406 44 - - HYPH cord-287123-ldkuwcc7 406 45 terminal terminal NN cord-287123-ldkuwcc7 406 46 residue residue NN cord-287123-ldkuwcc7 406 47 in in IN cord-287123-ldkuwcc7 406 48 Ac-9 Ac-9 NNP cord-287123-ldkuwcc7 406 49 QAWF QAWF NNP cord-287123-ldkuwcc7 406 50 12 12 CD cord-287123-ldkuwcc7 406 51 , , , cord-287123-ldkuwcc7 406 52 the the DT cord-287123-ldkuwcc7 406 53 core core NN cord-287123-ldkuwcc7 406 54 structure structure NN cord-287123-ldkuwcc7 406 55 of of IN cord-287123-ldkuwcc7 406 56 active active JJ cord-287123-ldkuwcc7 406 57 annexin annexin NN cord-287123-ldkuwcc7 406 58 peptides peptide NNS cord-287123-ldkuwcc7 406 59 [ [ -LRB- cord-287123-ldkuwcc7 406 60 219 219 CD cord-287123-ldkuwcc7 406 61 ] ] -RRB- cord-287123-ldkuwcc7 406 62 . . . cord-287123-ldkuwcc7 407 1 Using use VBG cord-287123-ldkuwcc7 407 2 the the DT cord-287123-ldkuwcc7 407 3 same same JJ cord-287123-ldkuwcc7 407 4 set set NN cord-287123-ldkuwcc7 407 5 of of IN cord-287123-ldkuwcc7 407 6 chimeric chimeric JJ cord-287123-ldkuwcc7 407 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 407 8 / / SYM cord-287123-ldkuwcc7 407 9 FPR2 FPR2 NNP cord-287123-ldkuwcc7 407 10 receptor receptor NN cord-287123-ldkuwcc7 407 11 [ [ -LRB- cord-287123-ldkuwcc7 407 12 206 206 CD cord-287123-ldkuwcc7 407 13 ] ] -RRB- cord-287123-ldkuwcc7 407 14 stably stably RB cord-287123-ldkuwcc7 407 15 expressed express VBD cord-287123-ldkuwcc7 407 16 in in IN cord-287123-ldkuwcc7 407 17 HEK293 HEK293 NNP cord-287123-ldkuwcc7 407 18 cells cell NNS cord-287123-ldkuwcc7 407 19 [ [ -LRB- cord-287123-ldkuwcc7 407 20 208 208 CD cord-287123-ldkuwcc7 407 21 ] ] -RRB- cord-287123-ldkuwcc7 407 22 , , , cord-287123-ldkuwcc7 407 23 the the DT cord-287123-ldkuwcc7 407 24 N n CD cord-287123-ldkuwcc7 407 25 - - HYPH cord-287123-ldkuwcc7 407 26 terminal terminal NN cord-287123-ldkuwcc7 407 27 region region NN cord-287123-ldkuwcc7 407 28 and and CC cord-287123-ldkuwcc7 407 29 the the DT cord-287123-ldkuwcc7 407 30 second second JJ cord-287123-ldkuwcc7 407 31 extracellular extracellular JJ cord-287123-ldkuwcc7 407 32 loop loop NN cord-287123-ldkuwcc7 407 33 of of IN cord-287123-ldkuwcc7 407 34 FPR2 FPR2 NNP cord-287123-ldkuwcc7 407 35 were be VBD cord-287123-ldkuwcc7 407 36 identified identify VBN cord-287123-ldkuwcc7 407 37 as as IN cord-287123-ldkuwcc7 407 38 required require VBN cord-287123-ldkuwcc7 407 39 for for IN cord-287123-ldkuwcc7 408 1 annexin annexin NNP cord-287123-ldkuwcc7 408 2 A1-mediated a1-mediate VBD cord-287123-ldkuwcc7 408 3 signaling signal VBG cord-287123-ldkuwcc7 408 4 [ [ -LRB- cord-287123-ldkuwcc7 408 5 220 220 CD cord-287123-ldkuwcc7 408 6 ] ] -RRB- cord-287123-ldkuwcc7 408 7 . . . cord-287123-ldkuwcc7 408 8 _SP cord-287123-ldkuwcc7 409 1 Due due IN cord-287123-ldkuwcc7 409 2 to to IN cord-287123-ldkuwcc7 409 3 the the DT cord-287123-ldkuwcc7 409 4 lack lack NN cord-287123-ldkuwcc7 409 5 of of IN cord-287123-ldkuwcc7 409 6 crystal crystal NN cord-287123-ldkuwcc7 409 7 structures structure NNS cord-287123-ldkuwcc7 409 8 for for IN cord-287123-ldkuwcc7 409 9 FPRs fpr NNS cord-287123-ldkuwcc7 409 10 , , , cord-287123-ldkuwcc7 409 11 homology homology NN cord-287123-ldkuwcc7 409 12 models model NNS cord-287123-ldkuwcc7 409 13 and and CC cord-287123-ldkuwcc7 409 14 molecular molecular JJ cord-287123-ldkuwcc7 409 15 docking docking NN cord-287123-ldkuwcc7 409 16 analysis analysis NN cord-287123-ldkuwcc7 409 17 based base VBN cord-287123-ldkuwcc7 409 18 on on IN cord-287123-ldkuwcc7 409 19 the the DT cord-287123-ldkuwcc7 409 20 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 409 21 / / SYM cord-287123-ldkuwcc7 409 22 chimera chimera NN cord-287123-ldkuwcc7 409 23 studies study NNS cord-287123-ldkuwcc7 409 24 represent represent VBP cord-287123-ldkuwcc7 409 25 an an DT cord-287123-ldkuwcc7 409 26 alternative alternative JJ cord-287123-ldkuwcc7 409 27 approach approach NN cord-287123-ldkuwcc7 409 28 for for IN cord-287123-ldkuwcc7 409 29 explaining explain VBG cord-287123-ldkuwcc7 409 30 ligand ligand NN cord-287123-ldkuwcc7 409 31 binding binding NN cord-287123-ldkuwcc7 409 32 and and CC cord-287123-ldkuwcc7 409 33 receptor receptor NN cord-287123-ldkuwcc7 409 34 activation activation NN cord-287123-ldkuwcc7 409 35 . . . cord-287123-ldkuwcc7 410 1 The the DT cord-287123-ldkuwcc7 410 2 current current JJ cord-287123-ldkuwcc7 410 3 homology homology NN cord-287123-ldkuwcc7 410 4 models model NNS cord-287123-ldkuwcc7 410 5 of of IN cord-287123-ldkuwcc7 410 6 FPR fpr NN cord-287123-ldkuwcc7 410 7 receptors receptor NNS cord-287123-ldkuwcc7 410 8 ( ( -LRB- cord-287123-ldkuwcc7 410 9 including include VBG cord-287123-ldkuwcc7 410 10 FPR1 FPR1 NNP cord-287123-ldkuwcc7 410 11 and and CC cord-287123-ldkuwcc7 410 12 FPR2 FPR2 NNP cord-287123-ldkuwcc7 410 13 ) ) -RRB- cord-287123-ldkuwcc7 410 14 are be VBP cord-287123-ldkuwcc7 410 15 generally generally RB cord-287123-ldkuwcc7 410 16 created create VBN cord-287123-ldkuwcc7 410 17 by by IN cord-287123-ldkuwcc7 410 18 using use VBG cord-287123-ldkuwcc7 410 19 the the DT cord-287123-ldkuwcc7 410 20 crystal crystal NN cord-287123-ldkuwcc7 410 21 structures structure NNS cord-287123-ldkuwcc7 410 22 of of IN cord-287123-ldkuwcc7 410 23 two two CD cord-287123-ldkuwcc7 410 24 classes class NNS cord-287123-ldkuwcc7 410 25 of of IN cord-287123-ldkuwcc7 410 26 receptors receptor NNS cord-287123-ldkuwcc7 410 27 : : : cord-287123-ldkuwcc7 410 28 ( ( -LRB- cord-287123-ldkuwcc7 410 29 1 1 LS cord-287123-ldkuwcc7 410 30 ) ) -RRB- cord-287123-ldkuwcc7 410 31 the the DT cord-287123-ldkuwcc7 410 32 bovine bovine JJ cord-287123-ldkuwcc7 410 33 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 410 34 receptor receptor NN cord-287123-ldkuwcc7 410 35 , , , cord-287123-ldkuwcc7 410 36 that that WDT cord-287123-ldkuwcc7 410 37 has have VBZ cord-287123-ldkuwcc7 410 38 a a DT cord-287123-ldkuwcc7 410 39 relatively relatively RB cord-287123-ldkuwcc7 410 40 low low JJ cord-287123-ldkuwcc7 410 41 sequence sequence NN cord-287123-ldkuwcc7 410 42 identity identity NN cord-287123-ldkuwcc7 410 43 to to IN cord-287123-ldkuwcc7 410 44 FPRs FPRs NNP cord-287123-ldkuwcc7 410 45 ( ( -LRB- cord-287123-ldkuwcc7 410 46 ~20 ~20 NFP cord-287123-ldkuwcc7 410 47 % % NN cord-287123-ldkuwcc7 410 48 ) ) -RRB- cord-287123-ldkuwcc7 410 49 and and CC cord-287123-ldkuwcc7 410 50 was be VBD cord-287123-ldkuwcc7 410 51 selected select VBN cord-287123-ldkuwcc7 410 52 as as IN cord-287123-ldkuwcc7 410 53 a a DT cord-287123-ldkuwcc7 410 54 template template NN cord-287123-ldkuwcc7 410 55 because because IN cord-287123-ldkuwcc7 410 56 of of IN cord-287123-ldkuwcc7 410 57 its -PRON- PRP$ cord-287123-ldkuwcc7 410 58 higher high JJR cord-287123-ldkuwcc7 410 59 resolution resolution NN cord-287123-ldkuwcc7 410 60 ( ( -LRB- cord-287123-ldkuwcc7 410 61 2.2 2.2 CD cord-287123-ldkuwcc7 410 62 Å å NN cord-287123-ldkuwcc7 410 63 ) ) -RRB- cord-287123-ldkuwcc7 410 64 [ [ -LRB- cord-287123-ldkuwcc7 410 65 221 221 CD cord-287123-ldkuwcc7 410 66 ] ] -RRB- cord-287123-ldkuwcc7 410 67 ; ; : cord-287123-ldkuwcc7 410 68 ( ( -LRB- cord-287123-ldkuwcc7 410 69 2 2 LS cord-287123-ldkuwcc7 410 70 ) ) -RRB- cord-287123-ldkuwcc7 410 71 the the DT cord-287123-ldkuwcc7 410 72 CXCR4-based cxcr4-based JJ cord-287123-ldkuwcc7 410 73 templates template NNS cord-287123-ldkuwcc7 410 74 , , , cord-287123-ldkuwcc7 410 75 usually usually RB cord-287123-ldkuwcc7 410 76 CXCR4 cxcr4 VB cord-287123-ldkuwcc7 410 77 alone alone RB cord-287123-ldkuwcc7 410 78 , , , cord-287123-ldkuwcc7 410 79 which which WDT cord-287123-ldkuwcc7 410 80 has have VBZ cord-287123-ldkuwcc7 410 81 a a DT cord-287123-ldkuwcc7 410 82 higher high JJR cord-287123-ldkuwcc7 410 83 sequence sequence NN cord-287123-ldkuwcc7 410 84 identity identity NN cord-287123-ldkuwcc7 410 85 with with IN cord-287123-ldkuwcc7 410 86 FPRs fpr NNS cord-287123-ldkuwcc7 410 87 ( ( -LRB- cord-287123-ldkuwcc7 410 88 28 28 CD cord-287123-ldkuwcc7 410 89 % % NN cord-287123-ldkuwcc7 410 90 ) ) -RRB- cord-287123-ldkuwcc7 410 91 but but CC cord-287123-ldkuwcc7 410 92 has have VBZ cord-287123-ldkuwcc7 410 93 a a DT cord-287123-ldkuwcc7 410 94 lower low JJR cord-287123-ldkuwcc7 410 95 resolution resolution NN cord-287123-ldkuwcc7 410 96 ( ( -LRB- cord-287123-ldkuwcc7 410 97 3.2 3.2 CD cord-287123-ldkuwcc7 410 98 Å å NN cord-287123-ldkuwcc7 410 99 ) ) -RRB- cord-287123-ldkuwcc7 410 100 compared compare VBN cord-287123-ldkuwcc7 410 101 to to IN cord-287123-ldkuwcc7 410 102 that that DT cord-287123-ldkuwcc7 410 103 of of IN cord-287123-ldkuwcc7 410 104 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 410 105 [ [ -LRB- cord-287123-ldkuwcc7 410 106 222 222 CD cord-287123-ldkuwcc7 410 107 ] ] -RRB- cord-287123-ldkuwcc7 410 108 . . . cord-287123-ldkuwcc7 411 1 A a DT cord-287123-ldkuwcc7 411 2 dual dual JJ cord-287123-ldkuwcc7 411 3 template template NN cord-287123-ldkuwcc7 411 4 strategy strategy NN cord-287123-ldkuwcc7 411 5 ( ( -LRB- cord-287123-ldkuwcc7 411 6 CXCR4 CXCR4 NNP cord-287123-ldkuwcc7 411 7 and and CC cord-287123-ldkuwcc7 411 8 µOR µor POS cord-287123-ldkuwcc7 411 9 opioid opioid JJ cord-287123-ldkuwcc7 411 10 receptor receptor NN cord-287123-ldkuwcc7 411 11 ) ) -RRB- cord-287123-ldkuwcc7 411 12 was be VBD cord-287123-ldkuwcc7 411 13 developed develop VBN cord-287123-ldkuwcc7 411 14 in in IN cord-287123-ldkuwcc7 411 15 a a DT cord-287123-ldkuwcc7 411 16 recent recent JJ cord-287123-ldkuwcc7 411 17 docking docking NN cord-287123-ldkuwcc7 411 18 study study NN cord-287123-ldkuwcc7 411 19 focused focus VBD cord-287123-ldkuwcc7 411 20 on on IN cord-287123-ldkuwcc7 411 21 FPR2 FPR2 NNP cord-287123-ldkuwcc7 411 22 and and CC cord-287123-ldkuwcc7 411 23 non non JJ cord-287123-ldkuwcc7 411 24 - - JJ cord-287123-ldkuwcc7 411 25 peptide peptide JJ cord-287123-ldkuwcc7 411 26 ligands ligand NNS cord-287123-ldkuwcc7 411 27 [ [ -LRB- cord-287123-ldkuwcc7 411 28 223 223 CD cord-287123-ldkuwcc7 411 29 ] ] -RRB- cord-287123-ldkuwcc7 411 30 . . . cord-287123-ldkuwcc7 412 1 Despite despite IN cord-287123-ldkuwcc7 412 2 questions question NNS cord-287123-ldkuwcc7 412 3 about about IN cord-287123-ldkuwcc7 412 4 the the DT cord-287123-ldkuwcc7 412 5 low low JJ cord-287123-ldkuwcc7 412 6 similarity similarity NN cord-287123-ldkuwcc7 412 7 of of IN cord-287123-ldkuwcc7 412 8 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 412 9 receptor receptor NN cord-287123-ldkuwcc7 412 10 with with IN cord-287123-ldkuwcc7 412 11 FPRs fpr NNS cord-287123-ldkuwcc7 412 12 , , , cord-287123-ldkuwcc7 412 13 several several JJ cord-287123-ldkuwcc7 412 14 interesting interesting JJ cord-287123-ldkuwcc7 412 15 points point NNS cord-287123-ldkuwcc7 412 16 have have VBP cord-287123-ldkuwcc7 412 17 been be VBN cord-287123-ldkuwcc7 412 18 made make VBN cord-287123-ldkuwcc7 412 19 by by IN cord-287123-ldkuwcc7 412 20 using use VBG cord-287123-ldkuwcc7 412 21 the the DT cord-287123-ldkuwcc7 412 22 homology homology NN cord-287123-ldkuwcc7 412 23 models model NNS cord-287123-ldkuwcc7 412 24 based base VBN cord-287123-ldkuwcc7 412 25 on on IN cord-287123-ldkuwcc7 412 26 this this DT cord-287123-ldkuwcc7 412 27 receptor receptor NN cord-287123-ldkuwcc7 412 28 . . . cord-287123-ldkuwcc7 413 1 The the DT cord-287123-ldkuwcc7 413 2 homology homology NN cord-287123-ldkuwcc7 413 3 model model NN cord-287123-ldkuwcc7 413 4 derived derive VBN cord-287123-ldkuwcc7 413 5 from from IN cord-287123-ldkuwcc7 413 6 the the DT cord-287123-ldkuwcc7 413 7 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 413 8 template template NN cord-287123-ldkuwcc7 413 9 shows show VBZ cord-287123-ldkuwcc7 413 10 that that IN cord-287123-ldkuwcc7 413 11 the the DT cord-287123-ldkuwcc7 413 12 FPR1 FPR1 NNP cord-287123-ldkuwcc7 413 13 ligand ligand NN cord-287123-ldkuwcc7 413 14 binding binding NN cord-287123-ldkuwcc7 413 15 site site NN cord-287123-ldkuwcc7 413 16 comprises comprise VBZ cord-287123-ldkuwcc7 413 17 two two CD cord-287123-ldkuwcc7 413 18 channels channel NNS cord-287123-ldkuwcc7 413 19 , , , cord-287123-ldkuwcc7 413 20 two two CD cord-287123-ldkuwcc7 413 21 cavities cavity NNS cord-287123-ldkuwcc7 413 22 , , , cord-287123-ldkuwcc7 413 23 and and CC cord-287123-ldkuwcc7 413 24 the the DT cord-287123-ldkuwcc7 413 25 bottom bottom NN cord-287123-ldkuwcc7 413 26 [ [ -LRB- cord-287123-ldkuwcc7 413 27 145 145 CD cord-287123-ldkuwcc7 413 28 ] ] -RRB- cord-287123-ldkuwcc7 413 29 . . . cord-287123-ldkuwcc7 414 1 Several several JJ cord-287123-ldkuwcc7 414 2 amino amino NN cord-287123-ldkuwcc7 414 3 acids acid NNS cord-287123-ldkuwcc7 414 4 are be VBP cord-287123-ldkuwcc7 414 5 found find VBN cord-287123-ldkuwcc7 414 6 to to TO cord-287123-ldkuwcc7 414 7 be be VB cord-287123-ldkuwcc7 414 8 involved involve VBN cord-287123-ldkuwcc7 414 9 in in IN cord-287123-ldkuwcc7 414 10 the the DT cord-287123-ldkuwcc7 414 11 interaction interaction NN cord-287123-ldkuwcc7 414 12 of of IN cord-287123-ldkuwcc7 414 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 414 14 with with IN cord-287123-ldkuwcc7 414 15 agonists agonist NNS cord-287123-ldkuwcc7 414 16 , , , cord-287123-ldkuwcc7 414 17 including include VBG cord-287123-ldkuwcc7 414 18 Asn Asn NNP cord-287123-ldkuwcc7 414 19 192 192 CD cord-287123-ldkuwcc7 414 20 , , , cord-287123-ldkuwcc7 414 21 Thr Thr NNP cord-287123-ldkuwcc7 414 22 199 199 CD cord-287123-ldkuwcc7 414 23 , , , cord-287123-ldkuwcc7 414 24 Arg Arg NNP cord-287123-ldkuwcc7 414 25 205 205 CD cord-287123-ldkuwcc7 414 26 , , , cord-287123-ldkuwcc7 414 27 Tyr Tyr NNP cord-287123-ldkuwcc7 414 28 257 257 CD cord-287123-ldkuwcc7 414 29 , , , cord-287123-ldkuwcc7 414 30 and and CC cord-287123-ldkuwcc7 414 31 Thr Thr NNP cord-287123-ldkuwcc7 414 32 265 265 CD cord-287123-ldkuwcc7 414 33 [ [ -LRB- cord-287123-ldkuwcc7 414 34 80 80 CD cord-287123-ldkuwcc7 414 35 , , , cord-287123-ldkuwcc7 414 36 145 145 CD cord-287123-ldkuwcc7 414 37 , , , cord-287123-ldkuwcc7 414 38 146 146 CD cord-287123-ldkuwcc7 414 39 , , , cord-287123-ldkuwcc7 414 40 212 212 CD cord-287123-ldkuwcc7 414 41 ] ] -RRB- cord-287123-ldkuwcc7 414 42 . . . cord-287123-ldkuwcc7 415 1 Docking docking NN cord-287123-ldkuwcc7 415 2 studies study NNS cord-287123-ldkuwcc7 415 3 with with IN cord-287123-ldkuwcc7 415 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 415 5 non non JJ cord-287123-ldkuwcc7 415 6 - - JJ cord-287123-ldkuwcc7 415 7 peptide peptide JJ cord-287123-ldkuwcc7 415 8 antagonists antagonist NNS cord-287123-ldkuwcc7 415 9 ( ( -LRB- cord-287123-ldkuwcc7 415 10 including include VBG cord-287123-ldkuwcc7 415 11 the the DT cord-287123-ldkuwcc7 415 12 bile bile NN cord-287123-ldkuwcc7 415 13 acids acid NNS cord-287123-ldkuwcc7 415 14 DCA DCA NNP cord-287123-ldkuwcc7 415 15 and and CC cord-287123-ldkuwcc7 415 16 CDCA CDCA NNP cord-287123-ldkuwcc7 415 17 ) ) -RRB- cord-287123-ldkuwcc7 415 18 suggested suggest VBD cord-287123-ldkuwcc7 415 19 that that IN cord-287123-ldkuwcc7 415 20 Thr Thr NNP cord-287123-ldkuwcc7 415 21 177 177 CD cord-287123-ldkuwcc7 415 22 , , , cord-287123-ldkuwcc7 415 23 Tyr Tyr NNP cord-287123-ldkuwcc7 415 24 257 257 CD cord-287123-ldkuwcc7 415 25 , , , cord-287123-ldkuwcc7 415 26 and and CC cord-287123-ldkuwcc7 415 27 Thr Thr NNP cord-287123-ldkuwcc7 415 28 265 265 CD cord-287123-ldkuwcc7 415 29 are be VBP cord-287123-ldkuwcc7 415 30 involved involve VBN cord-287123-ldkuwcc7 415 31 in in IN cord-287123-ldkuwcc7 415 32 the the DT cord-287123-ldkuwcc7 415 33 formation formation NN cord-287123-ldkuwcc7 415 34 of of IN cord-287123-ldkuwcc7 415 35 three three CD cord-287123-ldkuwcc7 415 36 stable stable JJ cord-287123-ldkuwcc7 415 37 H h NN cord-287123-ldkuwcc7 415 38 - - HYPH cord-287123-ldkuwcc7 415 39 bond bond NN cord-287123-ldkuwcc7 415 40 interactions interaction NNS cord-287123-ldkuwcc7 415 41 with with IN cord-287123-ldkuwcc7 415 42 DCA DCA NNP cord-287123-ldkuwcc7 415 43 and and CC cord-287123-ldkuwcc7 415 44 CDCA CDCA NNP cord-287123-ldkuwcc7 415 45 in in IN cord-287123-ldkuwcc7 415 46 the the DT cord-287123-ldkuwcc7 415 47 docked dock VBN cord-287123-ldkuwcc7 415 48 pose pose NN cord-287123-ldkuwcc7 415 49 [ [ -LRB- cord-287123-ldkuwcc7 415 50 224 224 CD cord-287123-ldkuwcc7 415 51 , , , cord-287123-ldkuwcc7 415 52 225 225 CD cord-287123-ldkuwcc7 415 53 ] ] -RRB- cord-287123-ldkuwcc7 415 54 . . . cord-287123-ldkuwcc7 416 1 A a DT cord-287123-ldkuwcc7 416 2 pharmacophore pharmacophore NN cord-287123-ldkuwcc7 416 3 model model NN cord-287123-ldkuwcc7 416 4 based base VBN cord-287123-ldkuwcc7 416 5 on on IN cord-287123-ldkuwcc7 416 6 best good JJS cord-287123-ldkuwcc7 416 7 docking docking NN cord-287123-ldkuwcc7 416 8 poses pose NNS cord-287123-ldkuwcc7 416 9 of of IN cord-287123-ldkuwcc7 416 10 four four CD cord-287123-ldkuwcc7 416 11 FPR1 FPR1 NNP cord-287123-ldkuwcc7 416 12 antagonists antagonist NNS cord-287123-ldkuwcc7 416 13 including include VBG cord-287123-ldkuwcc7 416 14 CsH CsH NNP cord-287123-ldkuwcc7 416 15 described describe VBD cord-287123-ldkuwcc7 416 16 three three CD cord-287123-ldkuwcc7 416 17 anchor anchor NN cord-287123-ldkuwcc7 416 18 points point NNS cord-287123-ldkuwcc7 416 19 : : : cord-287123-ldkuwcc7 416 20 two two CD cord-287123-ldkuwcc7 416 21 acceptors acceptor NNS cord-287123-ldkuwcc7 416 22 for for IN cord-287123-ldkuwcc7 416 23 H h NN cord-287123-ldkuwcc7 416 24 - - HYPH cord-287123-ldkuwcc7 416 25 bonding bonding NN cord-287123-ldkuwcc7 416 26 and and CC cord-287123-ldkuwcc7 416 27 one one CD cord-287123-ldkuwcc7 416 28 hydrophobic hydrophobic JJ cord-287123-ldkuwcc7 416 29 point point NN cord-287123-ldkuwcc7 416 30 [ [ -LRB- cord-287123-ldkuwcc7 416 31 172 172 CD cord-287123-ldkuwcc7 416 32 , , , cord-287123-ldkuwcc7 416 33 224 224 CD cord-287123-ldkuwcc7 416 34 , , , cord-287123-ldkuwcc7 416 35 226 226 CD cord-287123-ldkuwcc7 416 36 ] ] -RRB- cord-287123-ldkuwcc7 416 37 . . . cord-287123-ldkuwcc7 417 1 In in IN cord-287123-ldkuwcc7 417 2 comparison comparison NN cord-287123-ldkuwcc7 417 3 with with IN cord-287123-ldkuwcc7 417 4 the the DT cord-287123-ldkuwcc7 417 5 agonists agonist NNS cord-287123-ldkuwcc7 417 6 , , , cord-287123-ldkuwcc7 417 7 FPR1 FPR1 NNP cord-287123-ldkuwcc7 417 8 antagonists antagonist NNS cord-287123-ldkuwcc7 417 9 are be VBP cord-287123-ldkuwcc7 417 10 characterized characterize VBN cord-287123-ldkuwcc7 417 11 as as IN cord-287123-ldkuwcc7 417 12 containing contain VBG cord-287123-ldkuwcc7 417 13 more more JJR cord-287123-ldkuwcc7 417 14 OH OH NNP cord-287123-ldkuwcc7 417 15 groups group NNS cord-287123-ldkuwcc7 417 16 , , , cord-287123-ldkuwcc7 417 17 which which WDT cord-287123-ldkuwcc7 417 18 can can MD cord-287123-ldkuwcc7 417 19 serve serve VB cord-287123-ldkuwcc7 417 20 as as IN cord-287123-ldkuwcc7 417 21 H h NN cord-287123-ldkuwcc7 417 22 - - HYPH cord-287123-ldkuwcc7 417 23 bond bond NN cord-287123-ldkuwcc7 417 24 donors donor NNS cord-287123-ldkuwcc7 417 25 and/or and/or CC cord-287123-ldkuwcc7 417 26 acceptors acceptor NNS cord-287123-ldkuwcc7 417 27 upon upon IN cord-287123-ldkuwcc7 417 28 binding bind VBG cord-287123-ldkuwcc7 417 29 to to IN cord-287123-ldkuwcc7 417 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 417 31 [ [ -LRB- cord-287123-ldkuwcc7 417 32 6 6 CD cord-287123-ldkuwcc7 417 33 ] ] -RRB- cord-287123-ldkuwcc7 417 34 . . . cord-287123-ldkuwcc7 418 1 However however RB cord-287123-ldkuwcc7 418 2 , , , cord-287123-ldkuwcc7 418 3 the the DT cord-287123-ldkuwcc7 418 4 three three CD cord-287123-ldkuwcc7 418 5 - - HYPH cord-287123-ldkuwcc7 418 6 point point NN cord-287123-ldkuwcc7 418 7 model model NN cord-287123-ldkuwcc7 418 8 was be VBD cord-287123-ldkuwcc7 418 9 further further RB cord-287123-ldkuwcc7 418 10 proved prove VBN cord-287123-ldkuwcc7 418 11 to to TO cord-287123-ldkuwcc7 418 12 be be VB cord-287123-ldkuwcc7 418 13 not not RB cord-287123-ldkuwcc7 418 14 only only RB cord-287123-ldkuwcc7 418 15 fitted fit VBN cord-287123-ldkuwcc7 418 16 by by IN cord-287123-ldkuwcc7 418 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 418 18 antagonists antagonist NNS cord-287123-ldkuwcc7 418 19 but but CC cord-287123-ldkuwcc7 418 20 also also RB cord-287123-ldkuwcc7 418 21 by by IN cord-287123-ldkuwcc7 418 22 FPR1 FPR1 NNP cord-287123-ldkuwcc7 418 23 agonists agonist NNS cord-287123-ldkuwcc7 418 24 [ [ -LRB- cord-287123-ldkuwcc7 418 25 147 147 CD cord-287123-ldkuwcc7 418 26 , , , cord-287123-ldkuwcc7 418 27 227 227 CD cord-287123-ldkuwcc7 418 28 ] ] -RRB- cord-287123-ldkuwcc7 418 29 . . . cord-287123-ldkuwcc7 419 1 Thus thus RB cord-287123-ldkuwcc7 419 2 , , , cord-287123-ldkuwcc7 419 3 this this DT cord-287123-ldkuwcc7 419 4 model model NN cord-287123-ldkuwcc7 419 5 may may MD cord-287123-ldkuwcc7 419 6 be be VB cord-287123-ldkuwcc7 419 7 helpful helpful JJ cord-287123-ldkuwcc7 419 8 in in IN cord-287123-ldkuwcc7 419 9 prediction prediction NN cord-287123-ldkuwcc7 419 10 for for IN cord-287123-ldkuwcc7 419 11 structures structure NNS cord-287123-ldkuwcc7 419 12 of of IN cord-287123-ldkuwcc7 419 13 FPR1 FPR1 NNP cord-287123-ldkuwcc7 419 14 ligands ligand NNS cord-287123-ldkuwcc7 419 15 without without IN cord-287123-ldkuwcc7 419 16 discriminating discriminate VBG cord-287123-ldkuwcc7 419 17 agonists agonist NNS cord-287123-ldkuwcc7 419 18 and and CC cord-287123-ldkuwcc7 419 19 antagonists antagonist NNS cord-287123-ldkuwcc7 419 20 . . . cord-287123-ldkuwcc7 420 1 In in IN cord-287123-ldkuwcc7 420 2 another another DT cord-287123-ldkuwcc7 420 3 study study NN cord-287123-ldkuwcc7 420 4 , , , cord-287123-ldkuwcc7 420 5 a a DT cord-287123-ldkuwcc7 420 6 CXCR4-based cxcr4-based JJ cord-287123-ldkuwcc7 420 7 homology homology NN cord-287123-ldkuwcc7 420 8 model model NN cord-287123-ldkuwcc7 420 9 of of IN cord-287123-ldkuwcc7 420 10 FPR1 FPR1 NNP cord-287123-ldkuwcc7 420 11 suggested suggest VBD cord-287123-ldkuwcc7 420 12 an an DT cord-287123-ldkuwcc7 420 13 important important JJ cord-287123-ldkuwcc7 420 14 role role NN cord-287123-ldkuwcc7 420 15 of of IN cord-287123-ldkuwcc7 420 16 water water NN cord-287123-ldkuwcc7 420 17 molecule molecule NN cord-287123-ldkuwcc7 420 18 in in IN cord-287123-ldkuwcc7 420 19 discrimination discrimination NN cord-287123-ldkuwcc7 420 20 between between IN cord-287123-ldkuwcc7 420 21 FPR1 FPR1 NNP cord-287123-ldkuwcc7 420 22 agonists agonist NNS cord-287123-ldkuwcc7 420 23 and and CC cord-287123-ldkuwcc7 420 24 antagonists antagonist NNS cord-287123-ldkuwcc7 420 25 [ [ -LRB- cord-287123-ldkuwcc7 420 26 228 228 CD cord-287123-ldkuwcc7 420 27 ] ] -RRB- cord-287123-ldkuwcc7 420 28 . . . cord-287123-ldkuwcc7 421 1 In in IN cord-287123-ldkuwcc7 421 2 a a DT cord-287123-ldkuwcc7 421 3 comparative comparative JJ cord-287123-ldkuwcc7 421 4 model model NN cord-287123-ldkuwcc7 421 5 , , , cord-287123-ldkuwcc7 421 6 the the DT cord-287123-ldkuwcc7 421 7 potent potent JJ cord-287123-ldkuwcc7 421 8 antagonist antagonist NN cord-287123-ldkuwcc7 421 9 Boc-1 Boc-1 NNP cord-287123-ldkuwcc7 421 10 was be VBD cord-287123-ldkuwcc7 421 11 found find VBN cord-287123-ldkuwcc7 421 12 to to TO cord-287123-ldkuwcc7 421 13 interact interact VB cord-287123-ldkuwcc7 421 14 with with IN cord-287123-ldkuwcc7 421 15 FPR1 FPR1 NNP cord-287123-ldkuwcc7 421 16 by by IN cord-287123-ldkuwcc7 421 17 forming form VBG cord-287123-ldkuwcc7 421 18 H h NN cord-287123-ldkuwcc7 421 19 - - HYPH cord-287123-ldkuwcc7 421 20 bonds bond NNS cord-287123-ldkuwcc7 421 21 with with IN cord-287123-ldkuwcc7 421 22 Arg Arg NNP cord-287123-ldkuwcc7 421 23 84 84 CD cord-287123-ldkuwcc7 421 24 and and CC cord-287123-ldkuwcc7 421 25 Lys Lys NNP cord-287123-ldkuwcc7 421 26 85 85 CD cord-287123-ldkuwcc7 421 27 , , , cord-287123-ldkuwcc7 421 28 similarly similarly RB cord-287123-ldkuwcc7 421 29 to to IN cord-287123-ldkuwcc7 421 30 the the DT cord-287123-ldkuwcc7 421 31 interaction interaction NN cord-287123-ldkuwcc7 421 32 between between IN cord-287123-ldkuwcc7 421 33 fMLF fmlf NN cord-287123-ldkuwcc7 421 34 and and CC cord-287123-ldkuwcc7 421 35 FPR1 FPR1 NNP cord-287123-ldkuwcc7 421 36 . . . cord-287123-ldkuwcc7 422 1 However however RB cord-287123-ldkuwcc7 422 2 , , , cord-287123-ldkuwcc7 422 3 Boc-1 Boc-1 NNP cord-287123-ldkuwcc7 422 4 directly directly RB cord-287123-ldkuwcc7 422 5 forms form VBZ cord-287123-ldkuwcc7 422 6 an an DT cord-287123-ldkuwcc7 422 7 H h NN cord-287123-ldkuwcc7 422 8 - - HYPH cord-287123-ldkuwcc7 422 9 bond bond NN cord-287123-ldkuwcc7 422 10 with with IN cord-287123-ldkuwcc7 422 11 Asp Asp NNP cord-287123-ldkuwcc7 422 12 284 284 CD cord-287123-ldkuwcc7 422 13 while while IN cord-287123-ldkuwcc7 422 14 water water NN cord-287123-ldkuwcc7 422 15 molecule molecule NN cord-287123-ldkuwcc7 422 16 mediates mediate VBZ cord-287123-ldkuwcc7 422 17 H h NN cord-287123-ldkuwcc7 422 18 - - HYPH cord-287123-ldkuwcc7 422 19 bonding bonding NN cord-287123-ldkuwcc7 422 20 between between IN cord-287123-ldkuwcc7 422 21 the the DT cord-287123-ldkuwcc7 422 22 fMLF fMLF NNP cord-287123-ldkuwcc7 422 23 carbonyl carbonyl NNP cord-287123-ldkuwcc7 422 24 group group NN cord-287123-ldkuwcc7 422 25 and and CC cord-287123-ldkuwcc7 422 26 Asp Asp NNP cord-287123-ldkuwcc7 422 27 284 284 CD cord-287123-ldkuwcc7 422 28 [ [ -LRB- cord-287123-ldkuwcc7 422 29 228 228 CD cord-287123-ldkuwcc7 422 30 ] ] -RRB- cord-287123-ldkuwcc7 422 31 . . . cord-287123-ldkuwcc7 423 1 The the DT cord-287123-ldkuwcc7 423 2 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 423 3 - - HYPH cord-287123-ldkuwcc7 423 4 based base VBN cord-287123-ldkuwcc7 423 5 model model NN cord-287123-ldkuwcc7 423 6 with with IN cord-287123-ldkuwcc7 423 7 five five CD cord-287123-ldkuwcc7 423 8 FPR2 FPR2 NNP cord-287123-ldkuwcc7 423 9 agonists agonist NNS cord-287123-ldkuwcc7 423 10 described describe VBD cord-287123-ldkuwcc7 423 11 the the DT cord-287123-ldkuwcc7 423 12 binding bind VBG cord-287123-ldkuwcc7 423 13 pocket pocket NN cord-287123-ldkuwcc7 423 14 of of IN cord-287123-ldkuwcc7 423 15 FPR2 FPR2 NNP cord-287123-ldkuwcc7 423 16 as as IN cord-287123-ldkuwcc7 423 17 dumb dumb JJ cord-287123-ldkuwcc7 423 18 - - HYPH cord-287123-ldkuwcc7 423 19 bell bell JJ cord-287123-ldkuwcc7 423 20 shaped shaped NN cord-287123-ldkuwcc7 423 21 , , , cord-287123-ldkuwcc7 423 22 with with IN cord-287123-ldkuwcc7 423 23 a a DT cord-287123-ldkuwcc7 423 24 large large JJ cord-287123-ldkuwcc7 423 25 cavity cavity NN cord-287123-ldkuwcc7 423 26 and and CC cord-287123-ldkuwcc7 423 27 a a DT cord-287123-ldkuwcc7 423 28 small small JJ cord-287123-ldkuwcc7 423 29 cavity cavity NN cord-287123-ldkuwcc7 423 30 linked link VBN cord-287123-ldkuwcc7 423 31 by by IN cord-287123-ldkuwcc7 423 32 a a DT cord-287123-ldkuwcc7 423 33 narrow narrow JJ cord-287123-ldkuwcc7 423 34 channel channel NN cord-287123-ldkuwcc7 423 35 . . . cord-287123-ldkuwcc7 424 1 The the DT cord-287123-ldkuwcc7 424 2 proposed propose VBN cord-287123-ldkuwcc7 424 3 model model NN cord-287123-ldkuwcc7 424 4 comprises comprise VBZ cord-287123-ldkuwcc7 424 5 three three CD cord-287123-ldkuwcc7 424 6 sub sub NN cord-287123-ldkuwcc7 424 7 - - NNS cord-287123-ldkuwcc7 424 8 pockets pocket NNS cord-287123-ldkuwcc7 424 9 , , , cord-287123-ldkuwcc7 424 10 the the DT cord-287123-ldkuwcc7 424 11 pharmacophore pharmacophore NN cord-287123-ldkuwcc7 424 12 sub sub NN cord-287123-ldkuwcc7 424 13 - - JJ cord-287123-ldkuwcc7 424 14 pocket pocket NN cord-287123-ldkuwcc7 424 15 I -PRON- PRP cord-287123-ldkuwcc7 424 16 ( ( -LRB- cord-287123-ldkuwcc7 424 17 within within IN cord-287123-ldkuwcc7 424 18 the the DT cord-287123-ldkuwcc7 424 19 small small JJ cord-287123-ldkuwcc7 424 20 cavity cavity NN cord-287123-ldkuwcc7 424 21 ) ) -RRB- cord-287123-ldkuwcc7 424 22 surrounded surround VBN cord-287123-ldkuwcc7 424 23 by by IN cord-287123-ldkuwcc7 424 24 positive positive JJ cord-287123-ldkuwcc7 424 25 residues residue NNS cord-287123-ldkuwcc7 424 26 , , , cord-287123-ldkuwcc7 424 27 and and CC cord-287123-ldkuwcc7 424 28 the the DT cord-287123-ldkuwcc7 424 29 hydrophobic hydrophobic JJ cord-287123-ldkuwcc7 424 30 sub sub NN cord-287123-ldkuwcc7 424 31 - - HYPH cord-287123-ldkuwcc7 424 32 pockets pocket NNS cord-287123-ldkuwcc7 424 33 II II NNP cord-287123-ldkuwcc7 424 34 and and CC cord-287123-ldkuwcc7 424 35 III III NNP cord-287123-ldkuwcc7 424 36 ( ( -LRB- cord-287123-ldkuwcc7 424 37 within within IN cord-287123-ldkuwcc7 424 38 the the DT cord-287123-ldkuwcc7 424 39 large large JJ cord-287123-ldkuwcc7 424 40 cavity cavity NN cord-287123-ldkuwcc7 424 41 ) ) -RRB- cord-287123-ldkuwcc7 424 42 surrounded surround VBN cord-287123-ldkuwcc7 424 43 by by IN cord-287123-ldkuwcc7 424 44 polar polar JJ cord-287123-ldkuwcc7 424 45 residues residue NNS cord-287123-ldkuwcc7 424 46 [ [ -LRB- cord-287123-ldkuwcc7 424 47 82 82 CD cord-287123-ldkuwcc7 424 48 ] ] -RRB- cord-287123-ldkuwcc7 424 49 . . . cord-287123-ldkuwcc7 425 1 The the DT cord-287123-ldkuwcc7 425 2 FPR2-specific FPR2-specific NNP cord-287123-ldkuwcc7 425 3 peptide peptide NN cord-287123-ldkuwcc7 425 4 agonist agonist NN cord-287123-ldkuwcc7 425 5 WKYMVM wkymvm NN cord-287123-ldkuwcc7 425 6 fits fit VBZ cord-287123-ldkuwcc7 425 7 well well RB cord-287123-ldkuwcc7 425 8 with with IN cord-287123-ldkuwcc7 425 9 this this DT cord-287123-ldkuwcc7 425 10 model model NN cord-287123-ldkuwcc7 425 11 by by IN cord-287123-ldkuwcc7 425 12 occupying occupy VBG cord-287123-ldkuwcc7 425 13 all all DT cord-287123-ldkuwcc7 425 14 three three CD cord-287123-ldkuwcc7 425 15 sub sub NN cord-287123-ldkuwcc7 425 16 - - HYPH cord-287123-ldkuwcc7 425 17 pockets pocket NNS cord-287123-ldkuwcc7 425 18 , , , cord-287123-ldkuwcc7 425 19 with with IN cord-287123-ldkuwcc7 425 20 the the DT cord-287123-ldkuwcc7 425 21 N n CD cord-287123-ldkuwcc7 425 22 - - HYPH cord-287123-ldkuwcc7 425 23 terminal terminal JJ cord-287123-ldkuwcc7 425 24 indole indole NN cord-287123-ldkuwcc7 425 25 moiety moiety NN cord-287123-ldkuwcc7 425 26 located locate VBN cord-287123-ldkuwcc7 425 27 in in IN cord-287123-ldkuwcc7 425 28 sub sub JJ cord-287123-ldkuwcc7 425 29 - - JJ cord-287123-ldkuwcc7 425 30 pocket pocket NN cord-287123-ldkuwcc7 425 31 I -PRON- PRP cord-287123-ldkuwcc7 425 32 in in IN cord-287123-ldkuwcc7 425 33 the the DT cord-287123-ldkuwcc7 425 34 best good JJS cord-287123-ldkuwcc7 425 35 docked dock VBN cord-287123-ldkuwcc7 425 36 pose pose NN cord-287123-ldkuwcc7 425 37 [ [ -LRB- cord-287123-ldkuwcc7 425 38 6 6 CD cord-287123-ldkuwcc7 425 39 ] ] -RRB- cord-287123-ldkuwcc7 425 40 . . . cord-287123-ldkuwcc7 426 1 In in IN cord-287123-ldkuwcc7 426 2 another another DT cord-287123-ldkuwcc7 426 3 docking docking NN cord-287123-ldkuwcc7 426 4 simulation simulation NN cord-287123-ldkuwcc7 426 5 , , , cord-287123-ldkuwcc7 426 6 residues residue VBZ cord-287123-ldkuwcc7 426 7 His -PRON- PRP$ cord-287123-ldkuwcc7 426 8 102 102 CD cord-287123-ldkuwcc7 426 9 , , , cord-287123-ldkuwcc7 426 10 Val Val NNP cord-287123-ldkuwcc7 426 11 105 105 CD cord-287123-ldkuwcc7 426 12 , , , cord-287123-ldkuwcc7 426 13 Asp Asp NNP cord-287123-ldkuwcc7 426 14 106 106 CD cord-287123-ldkuwcc7 426 15 , , , cord-287123-ldkuwcc7 426 16 Leu Leu NNP cord-287123-ldkuwcc7 426 17 109 109 CD cord-287123-ldkuwcc7 426 18 , , , cord-287123-ldkuwcc7 426 19 and and CC cord-287123-ldkuwcc7 426 20 Trp Trp NNP cord-287123-ldkuwcc7 426 21 254 254 CD cord-287123-ldkuwcc7 426 22 were be VBD cord-287123-ldkuwcc7 426 23 identified identify VBN cord-287123-ldkuwcc7 426 24 as as IN cord-287123-ldkuwcc7 426 25 being be VBG cord-287123-ldkuwcc7 426 26 critical critical JJ cord-287123-ldkuwcc7 426 27 for for IN cord-287123-ldkuwcc7 426 28 agonist agonist NN cord-287123-ldkuwcc7 426 29 binding bind VBG cord-287123-ldkuwcc7 426 30 [ [ -LRB- cord-287123-ldkuwcc7 426 31 229 229 CD cord-287123-ldkuwcc7 426 32 ] ] -RRB- cord-287123-ldkuwcc7 426 33 . . . cord-287123-ldkuwcc7 427 1 In in IN cord-287123-ldkuwcc7 427 2 a a DT cord-287123-ldkuwcc7 427 3 more more RBR cord-287123-ldkuwcc7 427 4 recent recent JJ cord-287123-ldkuwcc7 427 5 study study NN cord-287123-ldkuwcc7 427 6 , , , cord-287123-ldkuwcc7 427 7 comparative comparative JJ cord-287123-ldkuwcc7 427 8 docking docking NN cord-287123-ldkuwcc7 427 9 analysis analysis NN cord-287123-ldkuwcc7 427 10 was be VBD cord-287123-ldkuwcc7 427 11 performed perform VBN cord-287123-ldkuwcc7 427 12 on on IN cord-287123-ldkuwcc7 427 13 a a DT cord-287123-ldkuwcc7 427 14 homology homology NN cord-287123-ldkuwcc7 427 15 model model NN cord-287123-ldkuwcc7 427 16 of of IN cord-287123-ldkuwcc7 427 17 FPR2 FPR2 NNP cord-287123-ldkuwcc7 427 18 that that WDT cord-287123-ldkuwcc7 427 19 used use VBD cord-287123-ldkuwcc7 427 20 CXCR4 CXCR4 NNS cord-287123-ldkuwcc7 427 21 and and CC cord-287123-ldkuwcc7 427 22 µOR µOR NNP cord-287123-ldkuwcc7 427 23 as as IN cord-287123-ldkuwcc7 427 24 a a DT cord-287123-ldkuwcc7 427 25 dual dual JJ cord-287123-ldkuwcc7 427 26 template template NN cord-287123-ldkuwcc7 427 27 [ [ -LRB- cord-287123-ldkuwcc7 427 28 223 223 CD cord-287123-ldkuwcc7 427 29 ] ] -RRB- cord-287123-ldkuwcc7 427 30 . . . cord-287123-ldkuwcc7 428 1 The the DT cord-287123-ldkuwcc7 428 2 model model NN cord-287123-ldkuwcc7 428 3 proposed propose VBD cord-287123-ldkuwcc7 428 4 that that IN cord-287123-ldkuwcc7 428 5 three three CD cord-287123-ldkuwcc7 428 6 hydrophobic hydrophobic JJ cord-287123-ldkuwcc7 428 7 clusters cluster NNS cord-287123-ldkuwcc7 428 8 are be VBP cord-287123-ldkuwcc7 428 9 important important JJ cord-287123-ldkuwcc7 428 10 in in IN cord-287123-ldkuwcc7 428 11 binding bind VBG cord-287123-ldkuwcc7 428 12 non non JJ cord-287123-ldkuwcc7 428 13 - - JJ cord-287123-ldkuwcc7 428 14 peptide peptide JJ cord-287123-ldkuwcc7 428 15 ligands ligand NNS cord-287123-ldkuwcc7 428 16 , , , cord-287123-ldkuwcc7 428 17 including include VBG cord-287123-ldkuwcc7 428 18 agonists agonist NNS cord-287123-ldkuwcc7 428 19 and and CC cord-287123-ldkuwcc7 428 20 antagonists antagonist NNS cord-287123-ldkuwcc7 428 21 . . . cord-287123-ldkuwcc7 429 1 The the DT cord-287123-ldkuwcc7 429 2 first first JJ cord-287123-ldkuwcc7 429 3 cluster cluster NN cord-287123-ldkuwcc7 429 4 is be VBZ cord-287123-ldkuwcc7 429 5 formed form VBN cord-287123-ldkuwcc7 429 6 by by IN cord-287123-ldkuwcc7 429 7 TM2 TM2 NNP cord-287123-ldkuwcc7 429 8 and and CC cord-287123-ldkuwcc7 429 9 TM3 TM3 NNP cord-287123-ldkuwcc7 429 10 while while IN cord-287123-ldkuwcc7 429 11 His -PRON- PRP$ cord-287123-ldkuwcc7 429 12 102 102 CD cord-287123-ldkuwcc7 429 13 is be VBZ cord-287123-ldkuwcc7 429 14 crucial crucial JJ cord-287123-ldkuwcc7 429 15 in in IN cord-287123-ldkuwcc7 429 16 the the DT cord-287123-ldkuwcc7 429 17 interaction interaction NN cord-287123-ldkuwcc7 429 18 with with IN cord-287123-ldkuwcc7 429 19 docked dock VBN cord-287123-ldkuwcc7 429 20 ligands ligand NNS cord-287123-ldkuwcc7 429 21 . . . cord-287123-ldkuwcc7 430 1 The the DT cord-287123-ldkuwcc7 430 2 second second JJ cord-287123-ldkuwcc7 430 3 cluster cluster NN cord-287123-ldkuwcc7 430 4 is be VBZ cord-287123-ldkuwcc7 430 5 located locate VBN cord-287123-ldkuwcc7 430 6 between between IN cord-287123-ldkuwcc7 430 7 TM6 tm6 NN cord-287123-ldkuwcc7 430 8 and and CC cord-287123-ldkuwcc7 430 9 TM7 TM7 NNP cord-287123-ldkuwcc7 430 10 with with IN cord-287123-ldkuwcc7 430 11 Phe Phe NNP cord-287123-ldkuwcc7 430 12 257 257 CD cord-287123-ldkuwcc7 430 13 as as IN cord-287123-ldkuwcc7 430 14 the the DT cord-287123-ldkuwcc7 430 15 key key JJ cord-287123-ldkuwcc7 430 16 residue residue NN cord-287123-ldkuwcc7 430 17 in in IN cord-287123-ldkuwcc7 430 18 binding bind VBG cord-287123-ldkuwcc7 430 19 to to IN cord-287123-ldkuwcc7 430 20 aromatic aromatic JJ cord-287123-ldkuwcc7 430 21 groups group NNS cord-287123-ldkuwcc7 430 22 of of IN cord-287123-ldkuwcc7 430 23 docked dock VBN cord-287123-ldkuwcc7 430 24 compounds compound NNS cord-287123-ldkuwcc7 430 25 . . . cord-287123-ldkuwcc7 431 1 The the DT cord-287123-ldkuwcc7 431 2 third third JJ cord-287123-ldkuwcc7 431 3 cluster cluster NN cord-287123-ldkuwcc7 431 4 is be VBZ cord-287123-ldkuwcc7 431 5 buried bury VBN cord-287123-ldkuwcc7 431 6 in in IN cord-287123-ldkuwcc7 431 7 the the DT cord-287123-ldkuwcc7 431 8 protein protein NN cord-287123-ldkuwcc7 431 9 consisting consist VBG cord-287123-ldkuwcc7 431 10 of of IN cord-287123-ldkuwcc7 431 11 residues residue NNS cord-287123-ldkuwcc7 431 12 Phe Phe NNP cord-287123-ldkuwcc7 431 13 74 74 CD cord-287123-ldkuwcc7 431 14 , , , cord-287123-ldkuwcc7 431 15 Val Val NNP cord-287123-ldkuwcc7 431 16 105 105 CD cord-287123-ldkuwcc7 431 17 , , , cord-287123-ldkuwcc7 431 18 Phe Phe NNP cord-287123-ldkuwcc7 431 19 257 257 CD cord-287123-ldkuwcc7 431 20 and and CC cord-287123-ldkuwcc7 431 21 Phe Phe NNP cord-287123-ldkuwcc7 431 22 292 292 CD cord-287123-ldkuwcc7 431 23 [ [ -LRB- cord-287123-ldkuwcc7 431 24 223 223 CD cord-287123-ldkuwcc7 431 25 ] ] -RRB- cord-287123-ldkuwcc7 431 26 . . . cord-287123-ldkuwcc7 432 1 The the DT cord-287123-ldkuwcc7 432 2 docking docking NN cord-287123-ldkuwcc7 432 3 model model NN cord-287123-ldkuwcc7 432 4 suggested suggest VBD cord-287123-ldkuwcc7 432 5 that that IN cord-287123-ldkuwcc7 432 6 the the DT cord-287123-ldkuwcc7 432 7 proper proper JJ cord-287123-ldkuwcc7 432 8 orientation orientation NN cord-287123-ldkuwcc7 432 9 is be VBZ cord-287123-ldkuwcc7 432 10 required require VBN cord-287123-ldkuwcc7 432 11 for for IN cord-287123-ldkuwcc7 432 12 penetration penetration NN cord-287123-ldkuwcc7 432 13 into into IN cord-287123-ldkuwcc7 432 14 the the DT cord-287123-ldkuwcc7 432 15 binding binding NN cord-287123-ldkuwcc7 432 16 site site NN cord-287123-ldkuwcc7 432 17 : : : cord-287123-ldkuwcc7 432 18 the the DT cord-287123-ldkuwcc7 432 19 peptide peptide NN cord-287123-ldkuwcc7 432 20 ligands ligand NNS cord-287123-ldkuwcc7 432 21 are be VBP cord-287123-ldkuwcc7 432 22 placed place VBN cord-287123-ldkuwcc7 432 23 upright upright JJ cord-287123-ldkuwcc7 432 24 while while IN cord-287123-ldkuwcc7 432 25 non non JJ cord-287123-ldkuwcc7 432 26 - - JJ cord-287123-ldkuwcc7 432 27 peptide peptide JJ cord-287123-ldkuwcc7 432 28 ligands ligand NNS cord-287123-ldkuwcc7 432 29 prefer prefer VBP cord-287123-ldkuwcc7 432 30 a a DT cord-287123-ldkuwcc7 432 31 more more RBR cord-287123-ldkuwcc7 432 32 horizontal horizontal JJ cord-287123-ldkuwcc7 432 33 position position NN cord-287123-ldkuwcc7 432 34 . . . cord-287123-ldkuwcc7 433 1 These these DT cord-287123-ldkuwcc7 433 2 findings finding NNS cord-287123-ldkuwcc7 433 3 have have VBP cord-287123-ldkuwcc7 433 4 yet yet RB cord-287123-ldkuwcc7 433 5 to to TO cord-287123-ldkuwcc7 433 6 be be VB cord-287123-ldkuwcc7 433 7 substantiated substantiate VBN cord-287123-ldkuwcc7 433 8 by by IN cord-287123-ldkuwcc7 433 9 mutational mutational JJ cord-287123-ldkuwcc7 433 10 studies study NNS cord-287123-ldkuwcc7 433 11 . . . cord-287123-ldkuwcc7 434 1 Still still RB cord-287123-ldkuwcc7 434 2 , , , cord-287123-ldkuwcc7 434 3 the the DT cord-287123-ldkuwcc7 434 4 differences difference NNS cord-287123-ldkuwcc7 434 5 in in IN cord-287123-ldkuwcc7 434 6 binding bind VBG cord-287123-ldkuwcc7 434 7 modes mode NNS cord-287123-ldkuwcc7 434 8 between between IN cord-287123-ldkuwcc7 434 9 antagonists antagonist NNS cord-287123-ldkuwcc7 434 10 and and CC cord-287123-ldkuwcc7 434 11 agonists agonist NNS cord-287123-ldkuwcc7 434 12 to to IN cord-287123-ldkuwcc7 434 13 FPR2 FPR2 NNP cord-287123-ldkuwcc7 434 14 are be VBP cord-287123-ldkuwcc7 434 15 not not RB cord-287123-ldkuwcc7 434 16 fully fully RB cord-287123-ldkuwcc7 434 17 understood understand VBN cord-287123-ldkuwcc7 434 18 . . . cord-287123-ldkuwcc7 435 1 To to IN cord-287123-ldkuwcc7 435 2 date date NN cord-287123-ldkuwcc7 435 3 , , , cord-287123-ldkuwcc7 435 4 there there EX cord-287123-ldkuwcc7 435 5 are be VBP cord-287123-ldkuwcc7 435 6 no no DT cord-287123-ldkuwcc7 435 7 reports report NNS cord-287123-ldkuwcc7 435 8 describing describe VBG cord-287123-ldkuwcc7 435 9 modeling modeling NN cord-287123-ldkuwcc7 435 10 of of IN cord-287123-ldkuwcc7 435 11 FPR3 FPR3 NNP cord-287123-ldkuwcc7 435 12 and and CC cord-287123-ldkuwcc7 435 13 mouse mouse VB cord-287123-ldkuwcc7 435 14 mFprs mFprs NNP cord-287123-ldkuwcc7 435 15 . . . cord-287123-ldkuwcc7 436 1 The the DT cord-287123-ldkuwcc7 436 2 FPRs fpr NNS cord-287123-ldkuwcc7 436 3 have have VBP cord-287123-ldkuwcc7 436 4 evolved evolve VBN cord-287123-ldkuwcc7 436 5 to to TO cord-287123-ldkuwcc7 436 6 be be VB cord-287123-ldkuwcc7 436 7 a a DT cord-287123-ldkuwcc7 436 8 class class NN cord-287123-ldkuwcc7 436 9 of of IN cord-287123-ldkuwcc7 436 10 receptors receptor NNS cord-287123-ldkuwcc7 436 11 that that WDT cord-287123-ldkuwcc7 436 12 not not RB cord-287123-ldkuwcc7 436 13 only only RB cord-287123-ldkuwcc7 436 14 recognize recognize VBP cord-287123-ldkuwcc7 436 15 bacteria bacteria NNS cord-287123-ldkuwcc7 436 16 - - HYPH cord-287123-ldkuwcc7 436 17 derived derive VBN cord-287123-ldkuwcc7 436 18 formyl formyl NN cord-287123-ldkuwcc7 436 19 peptides peptide NNS cord-287123-ldkuwcc7 436 20 but but CC cord-287123-ldkuwcc7 436 21 also also RB cord-287123-ldkuwcc7 436 22 ligands ligand NNS cord-287123-ldkuwcc7 436 23 with with IN cord-287123-ldkuwcc7 436 24 drastically drastically RB cord-287123-ldkuwcc7 436 25 different different JJ cord-287123-ldkuwcc7 436 26 structures structure NNS cord-287123-ldkuwcc7 436 27 , , , cord-287123-ldkuwcc7 436 28 including include VBG cord-287123-ldkuwcc7 436 29 non non JJ cord-287123-ldkuwcc7 436 30 - - JJ cord-287123-ldkuwcc7 436 31 formyl formyl JJ cord-287123-ldkuwcc7 436 32 peptides peptide NNS cord-287123-ldkuwcc7 436 33 of of IN cord-287123-ldkuwcc7 436 34 microbial microbial JJ cord-287123-ldkuwcc7 436 35 origins origin NNS cord-287123-ldkuwcc7 436 36 , , , cord-287123-ldkuwcc7 436 37 endogenous endogenous JJ cord-287123-ldkuwcc7 436 38 peptides peptide NNS cord-287123-ldkuwcc7 436 39 and and CC cord-287123-ldkuwcc7 436 40 synthetic synthetic JJ cord-287123-ldkuwcc7 436 41 small small JJ cord-287123-ldkuwcc7 436 42 molecules molecule NNS cord-287123-ldkuwcc7 436 43 . . . cord-287123-ldkuwcc7 437 1 Because because IN cord-287123-ldkuwcc7 437 2 of of IN cord-287123-ldkuwcc7 437 3 these these DT cord-287123-ldkuwcc7 437 4 features feature NNS cord-287123-ldkuwcc7 437 5 , , , cord-287123-ldkuwcc7 437 6 the the DT cord-287123-ldkuwcc7 437 7 FPRs fpr NNS cord-287123-ldkuwcc7 437 8 are be VBP cord-287123-ldkuwcc7 437 9 highly highly RB cord-287123-ldkuwcc7 437 10 ' ' `` cord-287123-ldkuwcc7 437 11 promiscuous promiscuous JJ cord-287123-ldkuwcc7 437 12 ' ' '' cord-287123-ldkuwcc7 437 13 in in IN cord-287123-ldkuwcc7 437 14 terms term NNS cord-287123-ldkuwcc7 437 15 of of IN cord-287123-ldkuwcc7 437 16 ligand ligand NN cord-287123-ldkuwcc7 437 17 recognition recognition NN cord-287123-ldkuwcc7 437 18 . . . cord-287123-ldkuwcc7 438 1 How how WRB cord-287123-ldkuwcc7 438 2 FPRs fpr NNS cord-287123-ldkuwcc7 438 3 recognize recognize VBP cord-287123-ldkuwcc7 438 4 these these DT cord-287123-ldkuwcc7 438 5 different different JJ cord-287123-ldkuwcc7 438 6 ligands ligand NNS cord-287123-ldkuwcc7 438 7 remains remain VBZ cord-287123-ldkuwcc7 438 8 unclear unclear JJ cord-287123-ldkuwcc7 438 9 at at IN cord-287123-ldkuwcc7 438 10 present present NN cord-287123-ldkuwcc7 438 11 without without IN cord-287123-ldkuwcc7 438 12 available available JJ cord-287123-ldkuwcc7 438 13 crystal crystal NN cord-287123-ldkuwcc7 438 14 structures structure NNS cord-287123-ldkuwcc7 438 15 . . . cord-287123-ldkuwcc7 439 1 Molecular molecular JJ cord-287123-ldkuwcc7 439 2 docking docking NN cord-287123-ldkuwcc7 439 3 and and CC cord-287123-ldkuwcc7 439 4 computer computer NN cord-287123-ldkuwcc7 439 5 simulation simulation NN cord-287123-ldkuwcc7 439 6 approaches approach NNS cord-287123-ldkuwcc7 439 7 combined combine VBN cord-287123-ldkuwcc7 439 8 with with IN cord-287123-ldkuwcc7 439 9 site site NN cord-287123-ldkuwcc7 439 10 - - HYPH cord-287123-ldkuwcc7 439 11 directed direct VBN cord-287123-ldkuwcc7 439 12 mutagenesis mutagenesis NN cord-287123-ldkuwcc7 439 13 , , , cord-287123-ldkuwcc7 439 14 however however RB cord-287123-ldkuwcc7 439 15 , , , cord-287123-ldkuwcc7 439 16 have have VBP cord-287123-ldkuwcc7 439 17 provided provide VBN cord-287123-ldkuwcc7 439 18 clues clue NNS cord-287123-ldkuwcc7 439 19 to to IN cord-287123-ldkuwcc7 439 20 our -PRON- PRP$ cord-287123-ldkuwcc7 439 21 understanding understanding NN cord-287123-ldkuwcc7 439 22 of of IN cord-287123-ldkuwcc7 439 23 how how WRB cord-287123-ldkuwcc7 439 24 formyl formyl NNP cord-287123-ldkuwcc7 439 25 peptides peptide NNS cord-287123-ldkuwcc7 439 26 interact interact VBP cord-287123-ldkuwcc7 439 27 with with IN cord-287123-ldkuwcc7 439 28 FPR1 FPR1 NNP cord-287123-ldkuwcc7 439 29 and and CC cord-287123-ldkuwcc7 439 30 to to IN cord-287123-ldkuwcc7 439 31 a a DT cord-287123-ldkuwcc7 439 32 lesser less JJR cord-287123-ldkuwcc7 439 33 extent extent NN cord-287123-ldkuwcc7 439 34 , , , cord-287123-ldkuwcc7 439 35 FPR2 FPR2 NNP cord-287123-ldkuwcc7 439 36 . . . cord-287123-ldkuwcc7 440 1 Over over IN cord-287123-ldkuwcc7 440 2 a a DT cord-287123-ldkuwcc7 440 3 very very RB cord-287123-ldkuwcc7 440 4 long long JJ cord-287123-ldkuwcc7 440 5 period period NN cord-287123-ldkuwcc7 440 6 of of IN cord-287123-ldkuwcc7 440 7 time time NN cord-287123-ldkuwcc7 440 8 , , , cord-287123-ldkuwcc7 440 9 adaptive adaptive JJ cord-287123-ldkuwcc7 440 10 evolution evolution NN cord-287123-ldkuwcc7 440 11 has have VBZ cord-287123-ldkuwcc7 440 12 occurred occur VBN cord-287123-ldkuwcc7 440 13 in in IN cord-287123-ldkuwcc7 440 14 FPRs fpr NNS cord-287123-ldkuwcc7 440 15 , , , cord-287123-ldkuwcc7 440 16 especially especially RB cord-287123-ldkuwcc7 440 17 FPR1 FPR1 NNP cord-287123-ldkuwcc7 440 18 , , , cord-287123-ldkuwcc7 440 19 with with IN cord-287123-ldkuwcc7 440 20 positive positive JJ cord-287123-ldkuwcc7 440 21 selection selection NN cord-287123-ldkuwcc7 440 22 for for IN cord-287123-ldkuwcc7 440 23 receptor receptor NN cord-287123-ldkuwcc7 440 24 interaction interaction NN cord-287123-ldkuwcc7 440 25 with with IN cord-287123-ldkuwcc7 440 26 the the DT cord-287123-ldkuwcc7 440 27 bona bona FW cord-287123-ldkuwcc7 440 28 fide fide JJ cord-287123-ldkuwcc7 440 29 or or CC cord-287123-ldkuwcc7 440 30 orthosteric orthosteric JJ cord-287123-ldkuwcc7 440 31 ligands ligand NNS cord-287123-ldkuwcc7 440 32 . . . cord-287123-ldkuwcc7 441 1 Indeed indeed RB cord-287123-ldkuwcc7 441 2 , , , cord-287123-ldkuwcc7 441 3 several several JJ cord-287123-ldkuwcc7 441 4 residues residue NNS cord-287123-ldkuwcc7 441 5 involved involve VBN cord-287123-ldkuwcc7 441 6 in in IN cord-287123-ldkuwcc7 441 7 H h NN cord-287123-ldkuwcc7 441 8 - - HYPH cord-287123-ldkuwcc7 441 9 bonding bonding NN cord-287123-ldkuwcc7 441 10 with with IN cord-287123-ldkuwcc7 441 11 amino amino JJ cord-287123-ldkuwcc7 441 12 acids acid NNS cord-287123-ldkuwcc7 441 13 in in IN cord-287123-ldkuwcc7 441 14 formyl formyl NNP cord-287123-ldkuwcc7 441 15 peptides peptide NNS cord-287123-ldkuwcc7 441 16 are be VBP cord-287123-ldkuwcc7 441 17 located locate VBN cord-287123-ldkuwcc7 441 18 within within IN cord-287123-ldkuwcc7 441 19 the the DT cord-287123-ldkuwcc7 441 20 predicted predict VBN cord-287123-ldkuwcc7 441 21 binding bind VBG cord-287123-ldkuwcc7 441 22 sites site NNS cord-287123-ldkuwcc7 441 23 undergoing undergo VBG cord-287123-ldkuwcc7 441 24 positive positive JJ cord-287123-ldkuwcc7 441 25 selection selection NN cord-287123-ldkuwcc7 441 26 , , , cord-287123-ldkuwcc7 441 27 suggesting suggest VBG cord-287123-ldkuwcc7 441 28 that that IN cord-287123-ldkuwcc7 441 29 human human JJ cord-287123-ldkuwcc7 441 30 FPR1 FPR1 NNP cord-287123-ldkuwcc7 441 31 is be VBZ cord-287123-ldkuwcc7 441 32 under under IN cord-287123-ldkuwcc7 441 33 selection selection NN cord-287123-ldkuwcc7 441 34 pressure pressure NN cord-287123-ldkuwcc7 441 35 for for IN cord-287123-ldkuwcc7 441 36 its -PRON- PRP$ cord-287123-ldkuwcc7 441 37 binding binding NN cord-287123-ldkuwcc7 441 38 of of IN cord-287123-ldkuwcc7 441 39 formyl formyl NNP cord-287123-ldkuwcc7 441 40 peptides peptide NNS cord-287123-ldkuwcc7 441 41 . . . cord-287123-ldkuwcc7 442 1 As as IN cord-287123-ldkuwcc7 442 2 for for IN cord-287123-ldkuwcc7 442 3 other other JJ cord-287123-ldkuwcc7 442 4 FPR1 FPR1 NNP cord-287123-ldkuwcc7 442 5 agonists agonist NNS cord-287123-ldkuwcc7 442 6 as as RB cord-287123-ldkuwcc7 442 7 well well RB cord-287123-ldkuwcc7 442 8 as as IN cord-287123-ldkuwcc7 442 9 for for IN cord-287123-ldkuwcc7 442 10 FPR3 FPR3 NNP cord-287123-ldkuwcc7 442 11 , , , cord-287123-ldkuwcc7 442 12 the the DT cord-287123-ldkuwcc7 442 13 picture picture NN cord-287123-ldkuwcc7 442 14 remains remain VBZ cord-287123-ldkuwcc7 442 15 unclear unclear JJ cord-287123-ldkuwcc7 442 16 . . . cord-287123-ldkuwcc7 443 1 There there EX cord-287123-ldkuwcc7 443 2 is be VBZ cord-287123-ldkuwcc7 443 3 no no DT cord-287123-ldkuwcc7 443 4 doubt doubt NN cord-287123-ldkuwcc7 443 5 that that IN cord-287123-ldkuwcc7 443 6 some some DT cord-287123-ldkuwcc7 443 7 agonists agonist NNS cord-287123-ldkuwcc7 443 8 for for IN cord-287123-ldkuwcc7 443 9 the the DT cord-287123-ldkuwcc7 443 10 FPRs fpr NNS cord-287123-ldkuwcc7 443 11 have have VBP cord-287123-ldkuwcc7 443 12 been be VBN cord-287123-ldkuwcc7 443 13 in in IN cord-287123-ldkuwcc7 443 14 existence existence NN cord-287123-ldkuwcc7 443 15 only only RB cord-287123-ldkuwcc7 443 16 recently recently RB cord-287123-ldkuwcc7 443 17 and and CC cord-287123-ldkuwcc7 443 18 they -PRON- PRP cord-287123-ldkuwcc7 443 19 are be VBP cord-287123-ldkuwcc7 443 20 likely likely JJ cord-287123-ldkuwcc7 443 21 candidates candidate NNS cord-287123-ldkuwcc7 443 22 for for IN cord-287123-ldkuwcc7 443 23 allosteric allosteric JJ cord-287123-ldkuwcc7 443 24 or or CC cord-287123-ldkuwcc7 443 25 ago ago RB cord-287123-ldkuwcc7 443 26 - - HYPH cord-287123-ldkuwcc7 443 27 allosteric allosteric JJ cord-287123-ldkuwcc7 443 28 modulators modulator NNS cord-287123-ldkuwcc7 443 29 of of IN cord-287123-ldkuwcc7 443 30 the the DT cord-287123-ldkuwcc7 443 31 FPRs fpr NNS cord-287123-ldkuwcc7 443 32 . . . cord-287123-ldkuwcc7 444 1 With with IN cord-287123-ldkuwcc7 444 2 respect respect NN cord-287123-ldkuwcc7 444 3 to to IN cord-287123-ldkuwcc7 444 4 FPR2 FPR2 NNP cord-287123-ldkuwcc7 444 5 , , , cord-287123-ldkuwcc7 444 6 it -PRON- PRP cord-287123-ldkuwcc7 444 7 apparently apparently RB cord-287123-ldkuwcc7 444 8 has have VBZ cord-287123-ldkuwcc7 444 9 diverged diverge VBN cord-287123-ldkuwcc7 444 10 from from IN cord-287123-ldkuwcc7 444 11 the the DT cord-287123-ldkuwcc7 444 12 evolutionary evolutionary JJ cord-287123-ldkuwcc7 444 13 path path NN cord-287123-ldkuwcc7 444 14 taken take VBN cord-287123-ldkuwcc7 444 15 by by IN cord-287123-ldkuwcc7 444 16 FPR1 FPR1 NNP cord-287123-ldkuwcc7 444 17 , , , cord-287123-ldkuwcc7 444 18 resulting result VBG cord-287123-ldkuwcc7 444 19 in in IN cord-287123-ldkuwcc7 444 20 a a DT cord-287123-ldkuwcc7 444 21 different different JJ cord-287123-ldkuwcc7 444 22 recognition recognition NN cord-287123-ldkuwcc7 444 23 profile profile NN cord-287123-ldkuwcc7 444 24 including include VBG cord-287123-ldkuwcc7 444 25 binding binding NN cord-287123-ldkuwcc7 444 26 of of IN cord-287123-ldkuwcc7 444 27 longer long JJR cord-287123-ldkuwcc7 444 28 formyl formyl NNP cord-287123-ldkuwcc7 444 29 peptides peptide NNS cord-287123-ldkuwcc7 444 30 and and CC cord-287123-ldkuwcc7 444 31 a a DT cord-287123-ldkuwcc7 444 32 wide wide JJ cord-287123-ldkuwcc7 444 33 range range NN cord-287123-ldkuwcc7 444 34 of of IN cord-287123-ldkuwcc7 444 35 endogenous endogenous JJ cord-287123-ldkuwcc7 444 36 and and CC cord-287123-ldkuwcc7 444 37 microbial microbial JJ cord-287123-ldkuwcc7 444 38 peptides peptide NNS cord-287123-ldkuwcc7 444 39 . . . cord-287123-ldkuwcc7 445 1 A a DT cord-287123-ldkuwcc7 445 2 better well JJR cord-287123-ldkuwcc7 445 3 understanding understanding NN cord-287123-ldkuwcc7 445 4 of of IN cord-287123-ldkuwcc7 445 5 the the DT cord-287123-ldkuwcc7 445 6 mechanisms mechanism NNS cord-287123-ldkuwcc7 445 7 by by IN cord-287123-ldkuwcc7 445 8 which which WDT cord-287123-ldkuwcc7 445 9 FPRs fpr NNS cord-287123-ldkuwcc7 445 10 interact interact VBP cord-287123-ldkuwcc7 445 11 with with IN cord-287123-ldkuwcc7 445 12 their -PRON- PRP$ cord-287123-ldkuwcc7 445 13 ligands ligand NNS cord-287123-ldkuwcc7 445 14 will will MD cord-287123-ldkuwcc7 445 15 help help VB cord-287123-ldkuwcc7 445 16 to to TO cord-287123-ldkuwcc7 445 17 sort sort VB cord-287123-ldkuwcc7 445 18 out out RP cord-287123-ldkuwcc7 445 19 agonists agonist NNS cord-287123-ldkuwcc7 445 20 and and CC cord-287123-ldkuwcc7 445 21 antagonists antagonist NNS cord-287123-ldkuwcc7 445 22 that that WDT cord-287123-ldkuwcc7 445 23 are be VBP cord-287123-ldkuwcc7 445 24 crucial crucial JJ cord-287123-ldkuwcc7 445 25 for for IN cord-287123-ldkuwcc7 445 26 the the DT cord-287123-ldkuwcc7 445 27 biological biological JJ cord-287123-ldkuwcc7 445 28 functions function NNS cord-287123-ldkuwcc7 445 29 of of IN cord-287123-ldkuwcc7 445 30 these these DT cord-287123-ldkuwcc7 445 31 receptors receptor NNS cord-287123-ldkuwcc7 445 32 , , , cord-287123-ldkuwcc7 445 33 and and CC cord-287123-ldkuwcc7 445 34 to to TO cord-287123-ldkuwcc7 445 35 speed speed VB cord-287123-ldkuwcc7 445 36 up up RP cord-287123-ldkuwcc7 445 37 identification identification NN cord-287123-ldkuwcc7 445 38 of of IN cord-287123-ldkuwcc7 445 39 therapeutically therapeutically RB cord-287123-ldkuwcc7 445 40 important important JJ cord-287123-ldkuwcc7 445 41 molecules molecule NNS cord-287123-ldkuwcc7 445 42 . . . cord-287123-ldkuwcc7 446 1 Author Author NNP cord-287123-ldkuwcc7 446 2 Contributions contribution NNS cord-287123-ldkuwcc7 446 3 : : : cord-287123-ldkuwcc7 447 1 H.Q.H. H.Q.H. NNP cord-287123-ldkuwcc7 447 2 and and CC cord-287123-ldkuwcc7 447 3 R.D.Y. R.D.Y. NNP cord-287123-ldkuwcc7 447 4 initiated initiate VBD cord-287123-ldkuwcc7 447 5 and and CC cord-287123-ldkuwcc7 447 6 designed design VBD cord-287123-ldkuwcc7 447 7 the the DT cord-287123-ldkuwcc7 447 8 study study NN cord-287123-ldkuwcc7 447 9 , , , cord-287123-ldkuwcc7 447 10 collected collect VBD cord-287123-ldkuwcc7 447 11 the the DT cord-287123-ldkuwcc7 447 12 literature literature NN cord-287123-ldkuwcc7 447 13 and and CC cord-287123-ldkuwcc7 447 14 wrote write VBD cord-287123-ldkuwcc7 447 15 the the DT cord-287123-ldkuwcc7 447 16 manuscript manuscript NN cord-287123-ldkuwcc7 447 17 . . . cord-287123-ldkuwcc7 448 1 The the DT cord-287123-ldkuwcc7 448 2 authors author NNS cord-287123-ldkuwcc7 448 3 declare declare VBP cord-287123-ldkuwcc7 448 4 no no DT cord-287123-ldkuwcc7 448 5 conflict conflict NN cord-287123-ldkuwcc7 448 6 of of IN cord-287123-ldkuwcc7 448 7 interest interest NN cord-287123-ldkuwcc7 448 8 . . . cord-287123-ldkuwcc7 449 1 The the DT cord-287123-ldkuwcc7 449 2 following following JJ cord-287123-ldkuwcc7 449 3 abbreviations abbreviation NNS cord-287123-ldkuwcc7 449 4 are be VBP cord-287123-ldkuwcc7 449 5 used use VBN cord-287123-ldkuwcc7 449 6 in in IN cord-287123-ldkuwcc7 449 7 this this DT cord-287123-ldkuwcc7 449 8 manuscript manuscript NN cord-287123-ldkuwcc7 449 9 : : : cord-287123-ldkuwcc7 449 10 _SP cord-287123-ldkuwcc7 449 11 Formyl Formyl NNP cord-287123-ldkuwcc7 449 12 peptide peptide NN cord-287123-ldkuwcc7 449 13 receptors receptor NNS cord-287123-ldkuwcc7 449 14 : : : cord-287123-ldkuwcc7 450 1 A a DT cord-287123-ldkuwcc7 450 2 promiscuous promiscuous JJ cord-287123-ldkuwcc7 450 3 subfamily subfamily NN cord-287123-ldkuwcc7 450 4 of of IN cord-287123-ldkuwcc7 450 5 g g NN cord-287123-ldkuwcc7 450 6 protein protein NN cord-287123-ldkuwcc7 450 7 - - HYPH cord-287123-ldkuwcc7 450 8 coupled couple VBN cord-287123-ldkuwcc7 450 9 receptors receptor NNS cord-287123-ldkuwcc7 450 10 controlling control VBG cord-287123-ldkuwcc7 450 11 immune immune JJ cord-287123-ldkuwcc7 450 12 responses response NNS cord-287123-ldkuwcc7 450 13 International International NNP cord-287123-ldkuwcc7 450 14 union union NN cord-287123-ldkuwcc7 450 15 of of IN cord-287123-ldkuwcc7 450 16 basic basic JJ cord-287123-ldkuwcc7 450 17 and and CC cord-287123-ldkuwcc7 450 18 clinical clinical JJ cord-287123-ldkuwcc7 450 19 pharmacology pharmacology NN cord-287123-ldkuwcc7 450 20 . . . cord-287123-ldkuwcc7 451 1 Lxxiii Lxxiii NNP cord-287123-ldkuwcc7 451 2 . . . cord-287123-ldkuwcc7 452 1 Nomenclature nomenclature NN cord-287123-ldkuwcc7 452 2 for for IN cord-287123-ldkuwcc7 452 3 the the DT cord-287123-ldkuwcc7 452 4 formyl formyl NNP cord-287123-ldkuwcc7 452 5 peptide peptide NN cord-287123-ldkuwcc7 452 6 receptor receptor NN cord-287123-ldkuwcc7 452 7 ( ( -LRB- cord-287123-ldkuwcc7 452 8 fpr fpr NNP cord-287123-ldkuwcc7 452 9 ) ) -RRB- cord-287123-ldkuwcc7 452 10 family family NN cord-287123-ldkuwcc7 452 11 N n CD cord-287123-ldkuwcc7 452 12 - - HYPH cord-287123-ldkuwcc7 452 13 formylmethionyl formylmethionyl NNP cord-287123-ldkuwcc7 452 14 peptides peptide NNS cord-287123-ldkuwcc7 452 15 as as IN cord-287123-ldkuwcc7 452 16 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 452 17 for for IN cord-287123-ldkuwcc7 452 18 leucocytes leucocytes NNP cord-287123-ldkuwcc7 453 1 Mitochondrial Mitochondrial NNP cord-287123-ldkuwcc7 453 2 N n CD cord-287123-ldkuwcc7 453 3 - - HYPH cord-287123-ldkuwcc7 453 4 formylmethionyl formylmethionyl NN cord-287123-ldkuwcc7 453 5 proteins protein NNS cord-287123-ldkuwcc7 453 6 as as IN cord-287123-ldkuwcc7 453 7 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 453 8 for for IN cord-287123-ldkuwcc7 453 9 neutrophils neutrophil NNS cord-287123-ldkuwcc7 453 10 Basic basic JJ cord-287123-ldkuwcc7 453 11 characteristics characteristic NNS cord-287123-ldkuwcc7 453 12 of of IN cord-287123-ldkuwcc7 453 13 the the DT cord-287123-ldkuwcc7 453 14 neutrophil neutrophil NN cord-287123-ldkuwcc7 453 15 receptors receptor NNS cord-287123-ldkuwcc7 453 16 that that WDT cord-287123-ldkuwcc7 453 17 recognize recognize VBP cord-287123-ldkuwcc7 453 18 formylated formylated JJ cord-287123-ldkuwcc7 453 19 peptides peptide NNS cord-287123-ldkuwcc7 453 20 , , , cord-287123-ldkuwcc7 453 21 a a DT cord-287123-ldkuwcc7 453 22 danger danger NN cord-287123-ldkuwcc7 453 23 - - HYPH cord-287123-ldkuwcc7 453 24 associated associate VBN cord-287123-ldkuwcc7 453 25 molecular molecular JJ cord-287123-ldkuwcc7 453 26 pattern pattern NN cord-287123-ldkuwcc7 453 27 generated generate VBN cord-287123-ldkuwcc7 453 28 by by IN cord-287123-ldkuwcc7 453 29 bacteria bacteria NNS cord-287123-ldkuwcc7 453 30 and and CC cord-287123-ldkuwcc7 453 31 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 453 32 Development Development NNP cord-287123-ldkuwcc7 453 33 of of IN cord-287123-ldkuwcc7 453 34 small small JJ cord-287123-ldkuwcc7 453 35 molecule molecule NN cord-287123-ldkuwcc7 453 36 non non JJ cord-287123-ldkuwcc7 453 37 - - JJ cord-287123-ldkuwcc7 453 38 peptide peptide JJ cord-287123-ldkuwcc7 453 39 formyl formyl NN cord-287123-ldkuwcc7 453 40 peptide peptide NN cord-287123-ldkuwcc7 453 41 receptor receptor NN cord-287123-ldkuwcc7 453 42 ( ( -LRB- cord-287123-ldkuwcc7 453 43 fpr fpr NNP cord-287123-ldkuwcc7 453 44 ) ) -RRB- cord-287123-ldkuwcc7 453 45 ligands ligand NNS cord-287123-ldkuwcc7 453 46 and and CC cord-287123-ldkuwcc7 453 47 molecular molecular JJ cord-287123-ldkuwcc7 453 48 modeling modeling NN cord-287123-ldkuwcc7 453 49 of of IN cord-287123-ldkuwcc7 453 50 their -PRON- PRP$ cord-287123-ldkuwcc7 453 51 recognition recognition NN cord-287123-ldkuwcc7 453 52 New new JJ cord-287123-ldkuwcc7 453 53 development development NN cord-287123-ldkuwcc7 453 54 in in IN cord-287123-ldkuwcc7 453 55 studies study NNS cord-287123-ldkuwcc7 453 56 of of IN cord-287123-ldkuwcc7 453 57 formyl formyl NNP cord-287123-ldkuwcc7 453 58 - - HYPH cord-287123-ldkuwcc7 453 59 peptide peptide NN cord-287123-ldkuwcc7 453 60 receptors receptor NNS cord-287123-ldkuwcc7 453 61 : : : cord-287123-ldkuwcc7 453 62 Critical critical JJ cord-287123-ldkuwcc7 453 63 roles role NNS cord-287123-ldkuwcc7 453 64 in in IN cord-287123-ldkuwcc7 453 65 host host NN cord-287123-ldkuwcc7 453 66 defense defense NN cord-287123-ldkuwcc7 453 67 Synthesis synthesis NN cord-287123-ldkuwcc7 453 68 and and CC cord-287123-ldkuwcc7 453 69 use use NN cord-287123-ldkuwcc7 453 70 of of IN cord-287123-ldkuwcc7 453 71 a a DT cord-287123-ldkuwcc7 453 72 novel novel JJ cord-287123-ldkuwcc7 453 73 n n NNP cord-287123-ldkuwcc7 453 74 - - HYPH cord-287123-ldkuwcc7 453 75 formyl formyl NN cord-287123-ldkuwcc7 453 76 peptide peptide NN cord-287123-ldkuwcc7 453 77 derivative derivative NN cord-287123-ldkuwcc7 453 78 to to TO cord-287123-ldkuwcc7 453 79 isolate isolate VB cord-287123-ldkuwcc7 453 80 a a DT cord-287123-ldkuwcc7 453 81 human human JJ cord-287123-ldkuwcc7 453 82 n n NNP cord-287123-ldkuwcc7 453 83 - - HYPH cord-287123-ldkuwcc7 453 84 formyl formyl NNP cord-287123-ldkuwcc7 453 85 peptide peptide NN cord-287123-ldkuwcc7 453 86 receptor receptor NN cord-287123-ldkuwcc7 453 87 cdna cdna NN cord-287123-ldkuwcc7 453 88 The the DT cord-287123-ldkuwcc7 453 89 human human JJ cord-287123-ldkuwcc7 453 90 N N NNP cord-287123-ldkuwcc7 453 91 - - HYPH cord-287123-ldkuwcc7 453 92 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 453 93 receptor receptor NN cord-287123-ldkuwcc7 453 94 . . . cord-287123-ldkuwcc7 454 1 Characterization characterization NN cord-287123-ldkuwcc7 454 2 of of IN cord-287123-ldkuwcc7 454 3 two two CD cord-287123-ldkuwcc7 454 4 cdna cdna NN cord-287123-ldkuwcc7 454 5 isolates isolate NNS cord-287123-ldkuwcc7 454 6 and and CC cord-287123-ldkuwcc7 454 7 evidence evidence NN cord-287123-ldkuwcc7 454 8 for for IN cord-287123-ldkuwcc7 454 9 a a DT cord-287123-ldkuwcc7 454 10 new new JJ cord-287123-ldkuwcc7 454 11 subfamily subfamily NN cord-287123-ldkuwcc7 454 12 of of IN cord-287123-ldkuwcc7 454 13 g g NN cord-287123-ldkuwcc7 454 14 - - HYPH cord-287123-ldkuwcc7 454 15 protein protein NN cord-287123-ldkuwcc7 454 16 - - HYPH cord-287123-ldkuwcc7 454 17 coupled couple VBN cord-287123-ldkuwcc7 454 18 receptors receptor NNS cord-287123-ldkuwcc7 454 19 Isolation isolation NN cord-287123-ldkuwcc7 454 20 of of IN cord-287123-ldkuwcc7 454 21 a a DT cord-287123-ldkuwcc7 454 22 cdna cdna NN cord-287123-ldkuwcc7 454 23 that that WDT cord-287123-ldkuwcc7 454 24 encodes encode VBZ cord-287123-ldkuwcc7 454 25 a a DT cord-287123-ldkuwcc7 454 26 novel novel NN cord-287123-ldkuwcc7 454 27 granulocyte granulocyte NN cord-287123-ldkuwcc7 454 28 N N NNP cord-287123-ldkuwcc7 454 29 - - HYPH cord-287123-ldkuwcc7 454 30 formyl formyl NNP cord-287123-ldkuwcc7 454 31 peptide peptide NN cord-287123-ldkuwcc7 454 32 receptor receptor NN cord-287123-ldkuwcc7 454 33 A a DT cord-287123-ldkuwcc7 454 34 structural structural JJ cord-287123-ldkuwcc7 454 35 homologue homologue NN cord-287123-ldkuwcc7 454 36 of of IN cord-287123-ldkuwcc7 454 37 the the DT cord-287123-ldkuwcc7 454 38 n n NNP cord-287123-ldkuwcc7 454 39 - - HYPH cord-287123-ldkuwcc7 454 40 formyl formyl NNP cord-287123-ldkuwcc7 454 41 peptide peptide NN cord-287123-ldkuwcc7 454 42 receptor receptor NN cord-287123-ldkuwcc7 454 43 . . . cord-287123-ldkuwcc7 455 1 Characterization characterization NN cord-287123-ldkuwcc7 455 2 and and CC cord-287123-ldkuwcc7 455 3 chromosome chromosome NN cord-287123-ldkuwcc7 455 4 mapping mapping NN cord-287123-ldkuwcc7 455 5 of of IN cord-287123-ldkuwcc7 455 6 a a DT cord-287123-ldkuwcc7 455 7 peptide peptide JJ cord-287123-ldkuwcc7 455 8 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 455 9 receptor receptor NN cord-287123-ldkuwcc7 455 10 family family NN cord-287123-ldkuwcc7 455 11 Mapping mapping NN cord-287123-ldkuwcc7 455 12 of of IN cord-287123-ldkuwcc7 455 13 genes gene NNS cord-287123-ldkuwcc7 455 14 for for IN cord-287123-ldkuwcc7 455 15 the the DT cord-287123-ldkuwcc7 455 16 human human JJ cord-287123-ldkuwcc7 455 17 c5a c5a JJ cord-287123-ldkuwcc7 455 18 receptor receptor NN cord-287123-ldkuwcc7 455 19 ( ( -LRB- cord-287123-ldkuwcc7 455 20 c5ar c5ar NNP cord-287123-ldkuwcc7 455 21 ) ) -RRB- cord-287123-ldkuwcc7 455 22 , , , cord-287123-ldkuwcc7 455 23 human human JJ cord-287123-ldkuwcc7 455 24 fmlp fmlp NNP cord-287123-ldkuwcc7 455 25 receptor receptor NN cord-287123-ldkuwcc7 455 26 ( ( -LRB- cord-287123-ldkuwcc7 455 27 fpr fpr NNP cord-287123-ldkuwcc7 455 28 ) ) -RRB- cord-287123-ldkuwcc7 455 29 , , , cord-287123-ldkuwcc7 455 30 and and CC cord-287123-ldkuwcc7 455 31 two two CD cord-287123-ldkuwcc7 455 32 fmlp fmlp NNS cord-287123-ldkuwcc7 455 33 receptor receptor NNP cord-287123-ldkuwcc7 455 34 homologue homologue NN cord-287123-ldkuwcc7 455 35 orphan orphan NN cord-287123-ldkuwcc7 455 36 receptors receptor NNS cord-287123-ldkuwcc7 455 37 ( ( -LRB- cord-287123-ldkuwcc7 455 38 fprh1 fprh1 NNP cord-287123-ldkuwcc7 455 39 , , , cord-287123-ldkuwcc7 455 40 fprh2 fprh2 NN cord-287123-ldkuwcc7 455 41 ) ) -RRB- cord-287123-ldkuwcc7 455 42 to to TO cord-287123-ldkuwcc7 455 43 chromosome chromosome VB cord-287123-ldkuwcc7 455 44 19 19 CD cord-287123-ldkuwcc7 455 45 Cloning cloning NN cord-287123-ldkuwcc7 455 46 of of IN cord-287123-ldkuwcc7 455 47 a a DT cord-287123-ldkuwcc7 455 48 cdna cdna NN cord-287123-ldkuwcc7 455 49 encoding encode VBG cord-287123-ldkuwcc7 455 50 a a DT cord-287123-ldkuwcc7 455 51 receptor receptor NN cord-287123-ldkuwcc7 455 52 related relate VBN cord-287123-ldkuwcc7 455 53 to to IN cord-287123-ldkuwcc7 455 54 the the DT cord-287123-ldkuwcc7 455 55 formyl formyl NNP cord-287123-ldkuwcc7 455 56 peptide peptide NN cord-287123-ldkuwcc7 455 57 receptor receptor NN cord-287123-ldkuwcc7 455 58 of of IN cord-287123-ldkuwcc7 455 59 human human JJ cord-287123-ldkuwcc7 455 60 neutrophils neutrophil NNS cord-287123-ldkuwcc7 455 61 Adaptive adaptive JJ cord-287123-ldkuwcc7 455 62 evolution evolution NN cord-287123-ldkuwcc7 455 63 of of IN cord-287123-ldkuwcc7 455 64 formyl formyl NNP cord-287123-ldkuwcc7 455 65 peptide peptide NN cord-287123-ldkuwcc7 455 66 receptors receptor NNS cord-287123-ldkuwcc7 455 67 in in IN cord-287123-ldkuwcc7 455 68 mammals mammal NNS cord-287123-ldkuwcc7 455 69 Potential potential JJ cord-287123-ldkuwcc7 455 70 role role NN cord-287123-ldkuwcc7 455 71 of of IN cord-287123-ldkuwcc7 455 72 the the DT cord-287123-ldkuwcc7 455 73 formyl formyl NNP cord-287123-ldkuwcc7 455 74 peptide peptide NN cord-287123-ldkuwcc7 455 75 receptor receptor NN cord-287123-ldkuwcc7 455 76 - - HYPH cord-287123-ldkuwcc7 455 77 like like JJ cord-287123-ldkuwcc7 455 78 1 1 CD cord-287123-ldkuwcc7 455 79 ( ( -LRB- cord-287123-ldkuwcc7 455 80 fprl1 fprl1 NN cord-287123-ldkuwcc7 455 81 ) ) -RRB- cord-287123-ldkuwcc7 455 82 in in IN cord-287123-ldkuwcc7 455 83 inflammatory inflammatory JJ cord-287123-ldkuwcc7 455 84 aspects aspect NNS cord-287123-ldkuwcc7 455 85 of of IN cord-287123-ldkuwcc7 455 86 Alzheimer Alzheimer NNP cord-287123-ldkuwcc7 455 87 's 's POS cord-287123-ldkuwcc7 455 88 disease disease NN cord-287123-ldkuwcc7 455 89 Bacterial bacterial JJ cord-287123-ldkuwcc7 455 90 lipopolysaccharide lipopolysaccharide NN cord-287123-ldkuwcc7 455 91 selectively selectively RB cord-287123-ldkuwcc7 455 92 up up RB cord-287123-ldkuwcc7 455 93 - - HYPH cord-287123-ldkuwcc7 455 94 regulates regulate VBZ cord-287123-ldkuwcc7 455 95 the the DT cord-287123-ldkuwcc7 455 96 function function NN cord-287123-ldkuwcc7 455 97 of of IN cord-287123-ldkuwcc7 455 98 the the DT cord-287123-ldkuwcc7 455 99 chemotactic chemotactic JJ cord-287123-ldkuwcc7 455 100 peptide peptide NN cord-287123-ldkuwcc7 455 101 receptor receptor NN cord-287123-ldkuwcc7 455 102 formyl formyl NNP cord-287123-ldkuwcc7 455 103 peptide peptide NN cord-287123-ldkuwcc7 455 104 receptor receptor NN cord-287123-ldkuwcc7 455 105 2 2 CD cord-287123-ldkuwcc7 455 106 in in IN cord-287123-ldkuwcc7 455 107 murine murine JJ cord-287123-ldkuwcc7 455 108 microglial microglial JJ cord-287123-ldkuwcc7 455 109 cells cell NNS cord-287123-ldkuwcc7 456 1 Interferon interferon NN cord-287123-ldkuwcc7 456 2 and and CC cord-287123-ldkuwcc7 456 3 granulopoiesis granulopoiesis NN cord-287123-ldkuwcc7 456 4 signatures signature NNS cord-287123-ldkuwcc7 456 5 in in IN cord-287123-ldkuwcc7 456 6 systemic systemic JJ cord-287123-ldkuwcc7 456 7 lupus lupus NN cord-287123-ldkuwcc7 456 8 erythematosus erythematosu VBZ cord-287123-ldkuwcc7 456 9 blood blood NN cord-287123-ldkuwcc7 456 10 Role role NN cord-287123-ldkuwcc7 456 11 of of IN cord-287123-ldkuwcc7 456 12 formyl formyl NNP cord-287123-ldkuwcc7 456 13 peptide peptide NN cord-287123-ldkuwcc7 456 14 receptor receptor NN cord-287123-ldkuwcc7 456 15 - - HYPH cord-287123-ldkuwcc7 456 16 like like JJ cord-287123-ldkuwcc7 456 17 1 1 CD cord-287123-ldkuwcc7 456 18 ( ( -LRB- cord-287123-ldkuwcc7 456 19 fprl1 fprl1 NN cord-287123-ldkuwcc7 456 20 / / SYM cord-287123-ldkuwcc7 456 21 fpr2 fpr2 NN cord-287123-ldkuwcc7 456 22 ) ) -RRB- cord-287123-ldkuwcc7 456 23 in in IN cord-287123-ldkuwcc7 456 24 mononuclear mononuclear JJ cord-287123-ldkuwcc7 456 25 phagocyte phagocyte NNP cord-287123-ldkuwcc7 456 26 responses response NNS cord-287123-ldkuwcc7 456 27 in in IN cord-287123-ldkuwcc7 456 28 Alzheimer Alzheimer NNP cord-287123-ldkuwcc7 456 29 disease disease NN cord-287123-ldkuwcc7 456 30 Leukocyte Leukocyte NNP cord-287123-ldkuwcc7 456 31 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 456 32 receptor receptor NN cord-287123-ldkuwcc7 456 33 fpr2 fpr2 NN cord-287123-ldkuwcc7 456 34 may may MD cord-287123-ldkuwcc7 456 35 accelerate accelerate VB cord-287123-ldkuwcc7 456 36 atherogenesis atherogenesis NN cord-287123-ldkuwcc7 456 37 Formyl Formyl NNP cord-287123-ldkuwcc7 456 38 peptide peptide NN cord-287123-ldkuwcc7 456 39 receptors receptor NNS cord-287123-ldkuwcc7 456 40 at at IN cord-287123-ldkuwcc7 456 41 the the DT cord-287123-ldkuwcc7 456 42 interface interface NN cord-287123-ldkuwcc7 456 43 of of IN cord-287123-ldkuwcc7 456 44 inflammation inflammation NN cord-287123-ldkuwcc7 456 45 , , , cord-287123-ldkuwcc7 456 46 angiogenesis angiogenesis NN cord-287123-ldkuwcc7 456 47 and and CC cord-287123-ldkuwcc7 456 48 tumor tumor NN cord-287123-ldkuwcc7 456 49 growth growth NN cord-287123-ldkuwcc7 457 1 Impaired impaired JJ cord-287123-ldkuwcc7 457 2 antibacterial antibacterial JJ cord-287123-ldkuwcc7 457 3 host host NN cord-287123-ldkuwcc7 457 4 defense defense NN cord-287123-ldkuwcc7 457 5 in in IN cord-287123-ldkuwcc7 457 6 mice mouse NNS cord-287123-ldkuwcc7 458 1 lacking lack VBG cord-287123-ldkuwcc7 458 2 the the DT cord-287123-ldkuwcc7 458 3 n n JJ cord-287123-ldkuwcc7 458 4 - - HYPH cord-287123-ldkuwcc7 458 5 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 458 6 receptor receptor NN cord-287123-ldkuwcc7 458 7 Formylpeptide Formylpeptide NNP cord-287123-ldkuwcc7 458 8 receptors receptor NNS cord-287123-ldkuwcc7 458 9 are be VBP cord-287123-ldkuwcc7 458 10 critical critical JJ cord-287123-ldkuwcc7 458 11 for for IN cord-287123-ldkuwcc7 458 12 rapid rapid JJ cord-287123-ldkuwcc7 458 13 neutrophil neutrophil NN cord-287123-ldkuwcc7 458 14 mobilization mobilization NN cord-287123-ldkuwcc7 458 15 in in IN cord-287123-ldkuwcc7 458 16 host host NN cord-287123-ldkuwcc7 458 17 defense defense NN cord-287123-ldkuwcc7 458 18 against against IN cord-287123-ldkuwcc7 458 19 Listeria Listeria NNP cord-287123-ldkuwcc7 458 20 monocytogenes monocytogenes NNP cord-287123-ldkuwcc7 458 21 Reduced reduce VBN cord-287123-ldkuwcc7 458 22 fear fear VBP cord-287123-ldkuwcc7 458 23 memory memory NN cord-287123-ldkuwcc7 458 24 and and CC cord-287123-ldkuwcc7 458 25 anxiety anxiety NN cord-287123-ldkuwcc7 458 26 - - HYPH cord-287123-ldkuwcc7 458 27 like like JJ cord-287123-ldkuwcc7 458 28 behavior behavior NN cord-287123-ldkuwcc7 458 29 in in IN cord-287123-ldkuwcc7 458 30 mice mouse NNS cord-287123-ldkuwcc7 458 31 lacking lack VBG cord-287123-ldkuwcc7 459 1 formylpeptide formylpeptide NNP cord-287123-ldkuwcc7 459 2 receptor receptor NNP cord-287123-ldkuwcc7 459 3 1 1 CD cord-287123-ldkuwcc7 459 4 N n NN cord-287123-ldkuwcc7 459 5 - - HYPH cord-287123-ldkuwcc7 459 6 formylpeptides formylpeptide NNS cord-287123-ldkuwcc7 459 7 induce induce VBP cord-287123-ldkuwcc7 459 8 two two CD cord-287123-ldkuwcc7 459 9 distinct distinct JJ cord-287123-ldkuwcc7 459 10 concentration concentration NN cord-287123-ldkuwcc7 459 11 optima optima NNP cord-287123-ldkuwcc7 459 12 for for IN cord-287123-ldkuwcc7 459 13 mouse mouse NN cord-287123-ldkuwcc7 459 14 neutrophil neutrophil NN cord-287123-ldkuwcc7 459 15 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 459 16 by by IN cord-287123-ldkuwcc7 459 17 differential differential JJ cord-287123-ldkuwcc7 459 18 interaction interaction NN cord-287123-ldkuwcc7 459 19 with with IN cord-287123-ldkuwcc7 459 20 two two CD cord-287123-ldkuwcc7 459 21 n n JJ cord-287123-ldkuwcc7 459 22 - - HYPH cord-287123-ldkuwcc7 459 23 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 459 24 receptor receptor NN cord-287123-ldkuwcc7 459 25 ( ( -LRB- cord-287123-ldkuwcc7 459 26 fpr fpr NNP cord-287123-ldkuwcc7 459 27 ) ) -RRB- cord-287123-ldkuwcc7 459 28 subtypes subtype NNS cord-287123-ldkuwcc7 459 29 . . . cord-287123-ldkuwcc7 460 1 Molecular molecular JJ cord-287123-ldkuwcc7 460 2 characterization characterization NN cord-287123-ldkuwcc7 460 3 of of IN cord-287123-ldkuwcc7 460 4 fpr2 fpr2 NN cord-287123-ldkuwcc7 460 5 , , , cord-287123-ldkuwcc7 460 6 a a DT cord-287123-ldkuwcc7 460 7 second second JJ cord-287123-ldkuwcc7 460 8 mouse mouse NN cord-287123-ldkuwcc7 460 9 neutrophil neutrophil NN cord-287123-ldkuwcc7 460 10 fpr fpr NNP cord-287123-ldkuwcc7 460 11 Identification Identification NNP cord-287123-ldkuwcc7 460 12 of of IN cord-287123-ldkuwcc7 460 13 formyl formyl NNP cord-287123-ldkuwcc7 460 14 peptides peptide NNS cord-287123-ldkuwcc7 460 15 from from IN cord-287123-ldkuwcc7 460 16 Listeria Listeria NNP cord-287123-ldkuwcc7 460 17 monocytogenes monocytogenes NNP cord-287123-ldkuwcc7 460 18 and and CC cord-287123-ldkuwcc7 460 19 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 460 20 aureus aureus NN cord-287123-ldkuwcc7 460 21 as as IN cord-287123-ldkuwcc7 460 22 potent potent JJ cord-287123-ldkuwcc7 460 23 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 460 24 for for IN cord-287123-ldkuwcc7 460 25 mouse mouse NN cord-287123-ldkuwcc7 460 26 neutrophils neutrophil NNS cord-287123-ldkuwcc7 460 27 Functional functional JJ cord-287123-ldkuwcc7 460 28 characterization characterization NN cord-287123-ldkuwcc7 460 29 of of IN cord-287123-ldkuwcc7 460 30 three three CD cord-287123-ldkuwcc7 460 31 mouse mouse NN cord-287123-ldkuwcc7 460 32 formyl formyl NNP cord-287123-ldkuwcc7 460 33 peptide peptide NN cord-287123-ldkuwcc7 460 34 receptors receptor NNS cord-287123-ldkuwcc7 460 35 Serum Serum NNP cord-287123-ldkuwcc7 460 36 amyloid amyloid NN cord-287123-ldkuwcc7 460 37 a a DT cord-287123-ldkuwcc7 460 38 is be VBZ cord-287123-ldkuwcc7 460 39 a a DT cord-287123-ldkuwcc7 460 40 chemotactic chemotactic JJ cord-287123-ldkuwcc7 460 41 agonist agonist NN cord-287123-ldkuwcc7 460 42 at at IN cord-287123-ldkuwcc7 460 43 fpr2 fpr2 NNP cord-287123-ldkuwcc7 460 44 , , , cord-287123-ldkuwcc7 460 45 a a DT cord-287123-ldkuwcc7 460 46 low low JJ cord-287123-ldkuwcc7 460 47 - - HYPH cord-287123-ldkuwcc7 460 48 affinity affinity NN cord-287123-ldkuwcc7 460 49 n n NN cord-287123-ldkuwcc7 460 50 - - HYPH cord-287123-ldkuwcc7 460 51 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 460 52 receptor receptor NN cord-287123-ldkuwcc7 460 53 on on IN cord-287123-ldkuwcc7 460 54 mouse mouse NN cord-287123-ldkuwcc7 460 55 neutrophils neutrophil NNS cord-287123-ldkuwcc7 460 56 Amyloid amyloid NN cord-287123-ldkuwcc7 460 57 - - HYPH cord-287123-ldkuwcc7 460 58 beta beta NN cord-287123-ldkuwcc7 460 59 induces induce VBZ cord-287123-ldkuwcc7 460 60 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 460 61 and and CC cord-287123-ldkuwcc7 460 62 oxidant oxidant JJ cord-287123-ldkuwcc7 460 63 stress stress NN cord-287123-ldkuwcc7 460 64 by by IN cord-287123-ldkuwcc7 460 65 acting act VBG cord-287123-ldkuwcc7 460 66 at at IN cord-287123-ldkuwcc7 460 67 formylpeptide formylpeptide NNP cord-287123-ldkuwcc7 460 68 receptor receptor NNP cord-287123-ldkuwcc7 460 69 2 2 CD cord-287123-ldkuwcc7 460 70 , , , cord-287123-ldkuwcc7 460 71 a a DT cord-287123-ldkuwcc7 460 72 g g NN cord-287123-ldkuwcc7 460 73 protein protein NN cord-287123-ldkuwcc7 460 74 - - HYPH cord-287123-ldkuwcc7 460 75 coupled couple VBN cord-287123-ldkuwcc7 460 76 receptor receptor NN cord-287123-ldkuwcc7 460 77 expressed express VBN cord-287123-ldkuwcc7 460 78 in in IN cord-287123-ldkuwcc7 460 79 phagocytes phagocyte NNS cord-287123-ldkuwcc7 460 80 and and CC cord-287123-ldkuwcc7 460 81 brain brain NN cord-287123-ldkuwcc7 460 82 F2l f2l NN cord-287123-ldkuwcc7 460 83 , , , cord-287123-ldkuwcc7 460 84 a a DT cord-287123-ldkuwcc7 460 85 peptide peptide NN cord-287123-ldkuwcc7 460 86 derived derive VBN cord-287123-ldkuwcc7 460 87 from from IN cord-287123-ldkuwcc7 460 88 heme heme NN cord-287123-ldkuwcc7 460 89 - - HYPH cord-287123-ldkuwcc7 460 90 binding bind VBG cord-287123-ldkuwcc7 460 91 protein protein NN cord-287123-ldkuwcc7 460 92 , , , cord-287123-ldkuwcc7 460 93 chemoattracts chemoattract VBZ cord-287123-ldkuwcc7 460 94 mouse mouse NN cord-287123-ldkuwcc7 460 95 neutrophils neutrophil NNS cord-287123-ldkuwcc7 460 96 by by IN cord-287123-ldkuwcc7 460 97 specifically specifically RB cord-287123-ldkuwcc7 460 98 activating activate VBG cord-287123-ldkuwcc7 460 99 fpr2 fpr2 NN cord-287123-ldkuwcc7 460 100 , , , cord-287123-ldkuwcc7 460 101 the the DT cord-287123-ldkuwcc7 460 102 low low JJ cord-287123-ldkuwcc7 460 103 - - HYPH cord-287123-ldkuwcc7 460 104 affinity affinity NN cord-287123-ldkuwcc7 460 105 n n NN cord-287123-ldkuwcc7 460 106 - - HYPH cord-287123-ldkuwcc7 460 107 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 460 108 receptor receptor NN cord-287123-ldkuwcc7 460 109 Identification identification NN cord-287123-ldkuwcc7 460 110 and and CC cord-287123-ldkuwcc7 460 111 characterization characterization NN cord-287123-ldkuwcc7 460 112 of of IN cord-287123-ldkuwcc7 460 113 an an DT cord-287123-ldkuwcc7 460 114 endogenous endogenous JJ cord-287123-ldkuwcc7 460 115 chemotactic chemotactic JJ cord-287123-ldkuwcc7 460 116 ligand ligand NN cord-287123-ldkuwcc7 460 117 specific specific NN cord-287123-ldkuwcc7 460 118 for for IN cord-287123-ldkuwcc7 460 119 fprl2 fprl2 NNP cord-287123-ldkuwcc7 461 1 Characterization characterization NN cord-287123-ldkuwcc7 461 2 of of IN cord-287123-ldkuwcc7 461 3 fpr fpr NN cord-287123-ldkuwcc7 461 4 - - HYPH cord-287123-ldkuwcc7 461 5 rs8 rs8 NN cord-287123-ldkuwcc7 461 6 , , , cord-287123-ldkuwcc7 461 7 an an DT cord-287123-ldkuwcc7 461 8 atypical atypical JJ cord-287123-ldkuwcc7 461 9 member member NN cord-287123-ldkuwcc7 461 10 of of IN cord-287123-ldkuwcc7 461 11 the the DT cord-287123-ldkuwcc7 461 12 mouse mouse NN cord-287123-ldkuwcc7 461 13 formyl formyl NNP cord-287123-ldkuwcc7 461 14 peptide peptide NN cord-287123-ldkuwcc7 461 15 receptor receptor NN cord-287123-ldkuwcc7 461 16 gene gene NN cord-287123-ldkuwcc7 461 17 family family NN cord-287123-ldkuwcc7 461 18 Formyl Formyl NNP cord-287123-ldkuwcc7 461 19 peptide peptide JJ cord-287123-ldkuwcc7 461 20 receptor receptor NN cord-287123-ldkuwcc7 461 21 - - HYPH cord-287123-ldkuwcc7 461 22 like like JJ cord-287123-ldkuwcc7 461 23 proteins protein NNS cord-287123-ldkuwcc7 461 24 are be VBP cord-287123-ldkuwcc7 461 25 a a DT cord-287123-ldkuwcc7 461 26 novel novel JJ cord-287123-ldkuwcc7 461 27 family family NN cord-287123-ldkuwcc7 461 28 of of IN cord-287123-ldkuwcc7 461 29 vomeronasal vomeronasal NN cord-287123-ldkuwcc7 461 30 chemosensors chemosensor NNS cord-287123-ldkuwcc7 461 31 Formyl Formyl NNP cord-287123-ldkuwcc7 461 32 peptide peptide NN cord-287123-ldkuwcc7 461 33 receptors receptor NNS cord-287123-ldkuwcc7 462 1 are be VBP cord-287123-ldkuwcc7 462 2 candidate candidate NN cord-287123-ldkuwcc7 462 3 chemosensory chemosensory NN cord-287123-ldkuwcc7 462 4 receptors receptor NNS cord-287123-ldkuwcc7 462 5 in in IN cord-287123-ldkuwcc7 462 6 the the DT cord-287123-ldkuwcc7 462 7 vomeronasal vomeronasal NN cord-287123-ldkuwcc7 462 8 organ organ NN cord-287123-ldkuwcc7 463 1 Aspirin aspirin NN cord-287123-ldkuwcc7 463 2 - - HYPH cord-287123-ldkuwcc7 463 3 triggered trigger VBN cord-287123-ldkuwcc7 463 4 15-epi 15-epi CD cord-287123-ldkuwcc7 463 5 - - HYPH cord-287123-ldkuwcc7 463 6 lipoxin lipoxin NNP cord-287123-ldkuwcc7 463 7 a4 a4 NNP cord-287123-ldkuwcc7 463 8 ( ( -LRB- cord-287123-ldkuwcc7 463 9 lxa4 lxa4 NN cord-287123-ldkuwcc7 463 10 ) ) -RRB- cord-287123-ldkuwcc7 463 11 and and CC cord-287123-ldkuwcc7 463 12 lxa4 lxa4 RB cord-287123-ldkuwcc7 464 1 stable stable JJ cord-287123-ldkuwcc7 464 2 analogues analogue NNS cord-287123-ldkuwcc7 464 3 are be VBP cord-287123-ldkuwcc7 464 4 potent potent JJ cord-287123-ldkuwcc7 464 5 inhibitors inhibitor NNS cord-287123-ldkuwcc7 464 6 of of IN cord-287123-ldkuwcc7 464 7 acute acute JJ cord-287123-ldkuwcc7 464 8 inflammation inflammation NN cord-287123-ldkuwcc7 464 9 : : : cord-287123-ldkuwcc7 464 10 Evidence evidence NN cord-287123-ldkuwcc7 464 11 for for IN cord-287123-ldkuwcc7 464 12 anti anti JJ cord-287123-ldkuwcc7 464 13 - - JJ cord-287123-ldkuwcc7 464 14 inflammatory inflammatory JJ cord-287123-ldkuwcc7 464 15 receptors receptor NNS cord-287123-ldkuwcc7 464 16 Characterization characterization NN cord-287123-ldkuwcc7 464 17 of of IN cord-287123-ldkuwcc7 464 18 two two CD cord-287123-ldkuwcc7 464 19 new new JJ cord-287123-ldkuwcc7 464 20 members member NNS cord-287123-ldkuwcc7 464 21 of of IN cord-287123-ldkuwcc7 464 22 the the DT cord-287123-ldkuwcc7 464 23 formyl formyl NNP cord-287123-ldkuwcc7 464 24 peptide peptide NN cord-287123-ldkuwcc7 464 25 receptor receptor NN cord-287123-ldkuwcc7 464 26 gene gene NN cord-287123-ldkuwcc7 464 27 family family NN cord-287123-ldkuwcc7 464 28 from from IN cord-287123-ldkuwcc7 464 29 129s6 129s6 NNP cord-287123-ldkuwcc7 464 30 mice mouse NNS cord-287123-ldkuwcc7 465 1 Intravascular Intravascular NNP cord-287123-ldkuwcc7 465 2 danger danger NN cord-287123-ldkuwcc7 465 3 signals signal NNS cord-287123-ldkuwcc7 465 4 guide guide VBP cord-287123-ldkuwcc7 465 5 neutrophils neutrophil NNS cord-287123-ldkuwcc7 465 6 to to IN cord-287123-ldkuwcc7 465 7 sites site NNS cord-287123-ldkuwcc7 465 8 of of IN cord-287123-ldkuwcc7 465 9 sterile sterile JJ cord-287123-ldkuwcc7 465 10 inflammation inflammation NN cord-287123-ldkuwcc7 466 1 Circulating circulate VBG cord-287123-ldkuwcc7 466 2 mitochondrial mitochondrial NN cord-287123-ldkuwcc7 466 3 damps damp NNS cord-287123-ldkuwcc7 467 1 cause cause VB cord-287123-ldkuwcc7 467 2 inflammatory inflammatory JJ cord-287123-ldkuwcc7 467 3 responses response NNS cord-287123-ldkuwcc7 467 4 to to TO cord-287123-ldkuwcc7 467 5 injury injury VB cord-287123-ldkuwcc7 467 6 Intravital Intravital NNP cord-287123-ldkuwcc7 467 7 imaging imaging NN cord-287123-ldkuwcc7 467 8 of of IN cord-287123-ldkuwcc7 467 9 neutrophil neutrophil NN cord-287123-ldkuwcc7 467 10 recruitment recruitment NN cord-287123-ldkuwcc7 467 11 reveals reveal VBZ cord-287123-ldkuwcc7 467 12 the the DT cord-287123-ldkuwcc7 467 13 efficacy efficacy NN cord-287123-ldkuwcc7 467 14 of of IN cord-287123-ldkuwcc7 467 15 fpr1 fpr1 NN cord-287123-ldkuwcc7 467 16 blockade blockade NN cord-287123-ldkuwcc7 467 17 in in IN cord-287123-ldkuwcc7 467 18 hepatic hepatic JJ cord-287123-ldkuwcc7 467 19 ischemia ischemia NN cord-287123-ldkuwcc7 467 20 - - HYPH cord-287123-ldkuwcc7 467 21 reperfusion reperfusion NN cord-287123-ldkuwcc7 467 22 injury injury NN cord-287123-ldkuwcc7 468 1 The the DT cord-287123-ldkuwcc7 468 2 isolation isolation NN cord-287123-ldkuwcc7 468 3 and and CC cord-287123-ldkuwcc7 468 4 partial partial JJ cord-287123-ldkuwcc7 468 5 characterization characterization NN cord-287123-ldkuwcc7 468 6 of of IN cord-287123-ldkuwcc7 468 7 neutrophil neutrophil NN cord-287123-ldkuwcc7 468 8 chemotactic chemotactic JJ cord-287123-ldkuwcc7 468 9 factors factor NNS cord-287123-ldkuwcc7 468 10 from from IN cord-287123-ldkuwcc7 468 11 escherichia escherichia NNP cord-287123-ldkuwcc7 468 12 coli coli NNS cord-287123-ldkuwcc7 469 1 Further further JJ cord-287123-ldkuwcc7 469 2 studies study NNS cord-287123-ldkuwcc7 469 3 on on IN cord-287123-ldkuwcc7 469 4 the the DT cord-287123-ldkuwcc7 469 5 structural structural JJ cord-287123-ldkuwcc7 469 6 requirements requirement NNS cord-287123-ldkuwcc7 469 7 for for IN cord-287123-ldkuwcc7 469 8 synthetic synthetic JJ cord-287123-ldkuwcc7 469 9 peptide peptide NN cord-287123-ldkuwcc7 469 10 chemoattractants chemoattractant NNS cord-287123-ldkuwcc7 469 11 Purification Purification NNP cord-287123-ldkuwcc7 469 12 and and CC cord-287123-ldkuwcc7 469 13 identification identification NN cord-287123-ldkuwcc7 469 14 of of IN cord-287123-ldkuwcc7 469 15 formyl formyl NN cord-287123-ldkuwcc7 469 16 - - HYPH cord-287123-ldkuwcc7 469 17 methionyl methionyl NNP cord-287123-ldkuwcc7 469 18 - - HYPH cord-287123-ldkuwcc7 469 19 leucyl leucyl NN cord-287123-ldkuwcc7 469 20 - - HYPH cord-287123-ldkuwcc7 469 21 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 469 22 as as IN cord-287123-ldkuwcc7 469 23 the the DT cord-287123-ldkuwcc7 469 24 major major JJ cord-287123-ldkuwcc7 469 25 peptide peptide NN cord-287123-ldkuwcc7 469 26 neutrophil neutrophil NN cord-287123-ldkuwcc7 469 27 chemotactic chemotactic JJ cord-287123-ldkuwcc7 469 28 factor factor NN cord-287123-ldkuwcc7 469 29 produced produce VBN cord-287123-ldkuwcc7 469 30 by by IN cord-287123-ldkuwcc7 469 31 Escherichia Escherichia NNP cord-287123-ldkuwcc7 469 32 coli coli VBZ cord-287123-ldkuwcc7 469 33 Acute acute JJ cord-287123-ldkuwcc7 469 34 colitis colitis NN cord-287123-ldkuwcc7 469 35 produced produce VBN cord-287123-ldkuwcc7 469 36 by by IN cord-287123-ldkuwcc7 469 37 chemotactic chemotactic JJ cord-287123-ldkuwcc7 469 38 peptides peptide NNS cord-287123-ldkuwcc7 469 39 in in IN cord-287123-ldkuwcc7 469 40 rats rat NNS cord-287123-ldkuwcc7 469 41 and and CC cord-287123-ldkuwcc7 469 42 mice mouse NNS cord-287123-ldkuwcc7 469 43 Chemotactic Chemotactic NNP cord-287123-ldkuwcc7 469 44 peptide peptide NN cord-287123-ldkuwcc7 469 45 - - HYPH cord-287123-ldkuwcc7 469 46 induced induce VBN cord-287123-ldkuwcc7 469 47 acute acute JJ cord-287123-ldkuwcc7 469 48 colitis colitis NN cord-287123-ldkuwcc7 469 49 in in IN cord-287123-ldkuwcc7 469 50 rabbits rabbit NNS cord-287123-ldkuwcc7 469 51 Guinea Guinea NNP cord-287123-ldkuwcc7 469 52 pig pig NN cord-287123-ldkuwcc7 469 53 ileum ileum NN cord-287123-ldkuwcc7 469 54 motility motility NN cord-287123-ldkuwcc7 469 55 stimulation stimulation NN cord-287123-ldkuwcc7 469 56 elicited elicit VBN cord-287123-ldkuwcc7 469 57 by by IN cord-287123-ldkuwcc7 469 58 n n NNP cord-287123-ldkuwcc7 469 59 - - HYPH cord-287123-ldkuwcc7 469 60 formyl formyl NNP cord-287123-ldkuwcc7 469 61 - - HYPH cord-287123-ldkuwcc7 469 62 met met NNP cord-287123-ldkuwcc7 469 63 - - HYPH cord-287123-ldkuwcc7 469 64 leu leu NN cord-287123-ldkuwcc7 469 65 - - HYPH cord-287123-ldkuwcc7 469 66 phe phe NNP cord-287123-ldkuwcc7 469 67 ( ( -LRB- cord-287123-ldkuwcc7 469 68 fmlf fmlf NNP cord-287123-ldkuwcc7 469 69 ) ) -RRB- cord-287123-ldkuwcc7 469 70 involves involve VBZ cord-287123-ldkuwcc7 469 71 neurotransmitters neurotransmitter NNS cord-287123-ldkuwcc7 469 72 and and CC cord-287123-ldkuwcc7 469 73 prostanoids prostanoid NNS cord-287123-ldkuwcc7 469 74 Chemotactic Chemotactic NNP cord-287123-ldkuwcc7 469 75 peptides peptide NNS cord-287123-ldkuwcc7 469 76 . . . cord-287123-ldkuwcc7 470 1 Mechanisms mechanism NNS cord-287123-ldkuwcc7 470 2 , , , cord-287123-ldkuwcc7 470 3 functions function NNS cord-287123-ldkuwcc7 470 4 , , , cord-287123-ldkuwcc7 470 5 and and CC cord-287123-ldkuwcc7 470 6 possible possible JJ cord-287123-ldkuwcc7 470 7 role role NN cord-287123-ldkuwcc7 470 8 in in IN cord-287123-ldkuwcc7 470 9 inflammatory inflammatory JJ cord-287123-ldkuwcc7 470 10 bowel bowel NN cord-287123-ldkuwcc7 470 11 disease disease NN cord-287123-ldkuwcc7 470 12 Increased increase VBN cord-287123-ldkuwcc7 470 13 neutrophil neutrophil NN cord-287123-ldkuwcc7 470 14 receptors receptor NNS cord-287123-ldkuwcc7 470 15 for for IN cord-287123-ldkuwcc7 470 16 and and CC cord-287123-ldkuwcc7 470 17 response response NN cord-287123-ldkuwcc7 470 18 to to IN cord-287123-ldkuwcc7 470 19 the the DT cord-287123-ldkuwcc7 470 20 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 470 21 bacterial bacterial JJ cord-287123-ldkuwcc7 470 22 peptide peptide NN cord-287123-ldkuwcc7 470 23 formyl formyl NNP cord-287123-ldkuwcc7 470 24 - - HYPH cord-287123-ldkuwcc7 470 25 methionyl methionyl NNP cord-287123-ldkuwcc7 470 26 - - HYPH cord-287123-ldkuwcc7 470 27 leucyl leucyl NN cord-287123-ldkuwcc7 470 28 - - HYPH cord-287123-ldkuwcc7 470 29 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 470 30 in in IN cord-287123-ldkuwcc7 470 31 crohn crohn NNP cord-287123-ldkuwcc7 470 32 's 's POS cord-287123-ldkuwcc7 470 33 disease disease NN cord-287123-ldkuwcc7 470 34 Defective defective JJ cord-287123-ldkuwcc7 470 35 polymorphonuclear polymorphonuclear JJ cord-287123-ldkuwcc7 470 36 leukocyte leukocyte NN cord-287123-ldkuwcc7 470 37 formyl formyl NNP cord-287123-ldkuwcc7 470 38 peptide peptide NN cord-287123-ldkuwcc7 470 39 receptor(s receptor(s NNP cord-287123-ldkuwcc7 470 40 ) ) -RRB- cord-287123-ldkuwcc7 470 41 in in IN cord-287123-ldkuwcc7 470 42 juvenile juvenile JJ cord-287123-ldkuwcc7 470 43 periodontitis periodontitis NN cord-287123-ldkuwcc7 470 44 Formyl Formyl NNP cord-287123-ldkuwcc7 470 45 - - HYPH cord-287123-ldkuwcc7 470 46 methionyl methionyl NN cord-287123-ldkuwcc7 470 47 - - HYPH cord-287123-ldkuwcc7 470 48 leucyl leucyl NN cord-287123-ldkuwcc7 470 49 - - HYPH cord-287123-ldkuwcc7 470 50 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 470 51 causes cause NNS cord-287123-ldkuwcc7 470 52 bronchoconstriction bronchoconstriction NN cord-287123-ldkuwcc7 470 53 in in IN cord-287123-ldkuwcc7 470 54 rabbits rabbit NNS cord-287123-ldkuwcc7 470 55 Haematological Haematological NNP cord-287123-ldkuwcc7 470 56 effects effect NNS cord-287123-ldkuwcc7 470 57 of of IN cord-287123-ldkuwcc7 470 58 inhalation inhalation NN cord-287123-ldkuwcc7 470 59 of of IN cord-287123-ldkuwcc7 470 60 n n NNP cord-287123-ldkuwcc7 470 61 - - HYPH cord-287123-ldkuwcc7 470 62 formyl formyl NNP cord-287123-ldkuwcc7 470 63 - - HYPH cord-287123-ldkuwcc7 470 64 methionyl methionyl NNP cord-287123-ldkuwcc7 470 65 - - HYPH cord-287123-ldkuwcc7 470 66 leucyl leucyl NN cord-287123-ldkuwcc7 470 67 - - HYPH cord-287123-ldkuwcc7 470 68 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 470 69 in in IN cord-287123-ldkuwcc7 470 70 man man NN cord-287123-ldkuwcc7 470 71 Hemodynamic Hemodynamic NNP cord-287123-ldkuwcc7 470 72 and and CC cord-287123-ldkuwcc7 470 73 metabolic metabolic JJ cord-287123-ldkuwcc7 470 74 effects effect NNS cord-287123-ldkuwcc7 470 75 of of IN cord-287123-ldkuwcc7 470 76 intravenous intravenous JJ cord-287123-ldkuwcc7 470 77 formyl formyl NNP cord-287123-ldkuwcc7 470 78 - - HYPH cord-287123-ldkuwcc7 470 79 methionyl methionyl NNP cord-287123-ldkuwcc7 470 80 - - HYPH cord-287123-ldkuwcc7 470 81 leucyl leucyl NN cord-287123-ldkuwcc7 470 82 - - HYPH cord-287123-ldkuwcc7 470 83 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 470 84 ( ( -LRB- cord-287123-ldkuwcc7 470 85 fmlp fmlp NNP cord-287123-ldkuwcc7 470 86 ) ) -RRB- cord-287123-ldkuwcc7 470 87 in in IN cord-287123-ldkuwcc7 470 88 rabbits rabbit NNS cord-287123-ldkuwcc7 471 1 Endotoxin endotoxin NN cord-287123-ldkuwcc7 471 2 augments augment VBZ cord-287123-ldkuwcc7 471 3 hemodynamic hemodynamic JJ cord-287123-ldkuwcc7 471 4 and and CC cord-287123-ldkuwcc7 471 5 metabolic metabolic JJ cord-287123-ldkuwcc7 471 6 effects effect NNS cord-287123-ldkuwcc7 471 7 of of IN cord-287123-ldkuwcc7 471 8 formyl formyl NN cord-287123-ldkuwcc7 471 9 - - HYPH cord-287123-ldkuwcc7 471 10 methionyl methionyl NNP cord-287123-ldkuwcc7 471 11 - - HYPH cord-287123-ldkuwcc7 471 12 leucyl leucyl NN cord-287123-ldkuwcc7 471 13 - - HYPH cord-287123-ldkuwcc7 471 14 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 471 15 ( ( -LRB- cord-287123-ldkuwcc7 471 16 fmlp fmlp NNP cord-287123-ldkuwcc7 471 17 ) ) -RRB- cord-287123-ldkuwcc7 471 18 in in IN cord-287123-ldkuwcc7 471 19 rabbits rabbit NNS cord-287123-ldkuwcc7 471 20 Structural structural JJ cord-287123-ldkuwcc7 471 21 changes change NNS cord-287123-ldkuwcc7 471 22 of of IN cord-287123-ldkuwcc7 471 23 the the DT cord-287123-ldkuwcc7 471 24 ligand ligand NN cord-287123-ldkuwcc7 471 25 and and CC cord-287123-ldkuwcc7 471 26 of of IN cord-287123-ldkuwcc7 471 27 the the DT cord-287123-ldkuwcc7 471 28 receptor receptor NN cord-287123-ldkuwcc7 472 1 alters alter VBZ cord-287123-ldkuwcc7 472 2 the the DT cord-287123-ldkuwcc7 472 3 receptor receptor NN cord-287123-ldkuwcc7 472 4 preference preference NN cord-287123-ldkuwcc7 472 5 for for IN cord-287123-ldkuwcc7 472 6 neutrophil neutrophil NN cord-287123-ldkuwcc7 472 7 activating activate VBG cord-287123-ldkuwcc7 472 8 peptides peptide NNS cord-287123-ldkuwcc7 472 9 starting start VBG cord-287123-ldkuwcc7 472 10 with with IN cord-287123-ldkuwcc7 472 11 a a DT cord-287123-ldkuwcc7 472 12 formylmethionyl formylmethionyl NNP cord-287123-ldkuwcc7 472 13 group group NN cord-287123-ldkuwcc7 472 14 Human human JJ cord-287123-ldkuwcc7 472 15 mitochondria mitochondrion NNS cord-287123-ldkuwcc7 472 16 - - HYPH cord-287123-ldkuwcc7 472 17 derived derive VBN cord-287123-ldkuwcc7 472 18 n n JJ cord-287123-ldkuwcc7 472 19 - - HYPH cord-287123-ldkuwcc7 472 20 formylated formylate VBN cord-287123-ldkuwcc7 472 21 peptides peptide NNS cord-287123-ldkuwcc7 472 22 are be VBP cord-287123-ldkuwcc7 472 23 novel novel JJ cord-287123-ldkuwcc7 472 24 agonists agonist NNS cord-287123-ldkuwcc7 472 25 equally equally RB cord-287123-ldkuwcc7 472 26 active active JJ cord-287123-ldkuwcc7 472 27 on on IN cord-287123-ldkuwcc7 472 28 fpr fpr NN cord-287123-ldkuwcc7 472 29 and and CC cord-287123-ldkuwcc7 472 30 fprl1 fprl1 NN cord-287123-ldkuwcc7 472 31 , , , cord-287123-ldkuwcc7 472 32 while while IN cord-287123-ldkuwcc7 472 33 Listeria Listeria NNP cord-287123-ldkuwcc7 472 34 monocytogenes monocytogenes NN cord-287123-ldkuwcc7 472 35 - - HYPH cord-287123-ldkuwcc7 472 36 derived derive VBN cord-287123-ldkuwcc7 472 37 peptides peptide NNS cord-287123-ldkuwcc7 472 38 preferentially preferentially RB cord-287123-ldkuwcc7 472 39 activate activate VBP cord-287123-ldkuwcc7 472 40 fpr fpr NN cord-287123-ldkuwcc7 472 41 Mitocryptide-2 Mitocryptide-2 NNP cord-287123-ldkuwcc7 472 42 , , , cord-287123-ldkuwcc7 472 43 a a DT cord-287123-ldkuwcc7 472 44 neutrophil neutrophil NN cord-287123-ldkuwcc7 472 45 - - HYPH cord-287123-ldkuwcc7 472 46 activating activate VBG cord-287123-ldkuwcc7 472 47 cryptide cryptide NN cord-287123-ldkuwcc7 472 48 , , , cord-287123-ldkuwcc7 472 49 is be VBZ cord-287123-ldkuwcc7 472 50 a a DT cord-287123-ldkuwcc7 472 51 specific specific JJ cord-287123-ldkuwcc7 472 52 endogenous endogenous JJ cord-287123-ldkuwcc7 472 53 agonist agonist NN cord-287123-ldkuwcc7 472 54 for for IN cord-287123-ldkuwcc7 472 55 formyl formyl NNP cord-287123-ldkuwcc7 472 56 - - HYPH cord-287123-ldkuwcc7 472 57 peptide peptide NN cord-287123-ldkuwcc7 472 58 receptor receptor NN cord-287123-ldkuwcc7 472 59 - - HYPH cord-287123-ldkuwcc7 472 60 like like JJ cord-287123-ldkuwcc7 472 61 1 1 CD cord-287123-ldkuwcc7 472 62 A a DT cord-287123-ldkuwcc7 472 63 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 472 64 peptide peptide NN cord-287123-ldkuwcc7 472 65 from from IN cord-287123-ldkuwcc7 472 66 Helicobacter Helicobacter NNP cord-287123-ldkuwcc7 472 67 pylori pylori NN cord-287123-ldkuwcc7 472 68 activates activate VBZ cord-287123-ldkuwcc7 472 69 monocytes monocyte NNS cord-287123-ldkuwcc7 472 70 to to TO cord-287123-ldkuwcc7 472 71 induce induce VB cord-287123-ldkuwcc7 472 72 lymphocyte lymphocyte NN cord-287123-ldkuwcc7 472 73 dysfunction dysfunction NN cord-287123-ldkuwcc7 472 74 and and CC cord-287123-ldkuwcc7 472 75 apoptosis apoptosis NN cord-287123-ldkuwcc7 472 76 A a DT cord-287123-ldkuwcc7 472 77 seven seven CD cord-287123-ldkuwcc7 472 78 - - HYPH cord-287123-ldkuwcc7 472 79 transmembrane transmembrane NN cord-287123-ldkuwcc7 472 80 , , , cord-287123-ldkuwcc7 472 81 g g NN cord-287123-ldkuwcc7 472 82 protein protein NN cord-287123-ldkuwcc7 472 83 - - HYPH cord-287123-ldkuwcc7 472 84 coupled couple VBN cord-287123-ldkuwcc7 472 85 receptor receptor NN cord-287123-ldkuwcc7 472 86 , , , cord-287123-ldkuwcc7 472 87 fprl1 fprl1 NN cord-287123-ldkuwcc7 472 88 , , , cord-287123-ldkuwcc7 472 89 mediates mediate VBZ cord-287123-ldkuwcc7 472 90 the the DT cord-287123-ldkuwcc7 472 91 chemotactic chemotactic JJ cord-287123-ldkuwcc7 472 92 activity activity NN cord-287123-ldkuwcc7 472 93 of of IN cord-287123-ldkuwcc7 472 94 serum serum NN cord-287123-ldkuwcc7 472 95 amyloid amyloid NN cord-287123-ldkuwcc7 472 96 a a DT cord-287123-ldkuwcc7 472 97 for for IN cord-287123-ldkuwcc7 472 98 human human JJ cord-287123-ldkuwcc7 472 99 phagocytic phagocytic JJ cord-287123-ldkuwcc7 472 100 cells cell NNS cord-287123-ldkuwcc7 472 101 Structural structural JJ cord-287123-ldkuwcc7 472 102 mechanism mechanism NN cord-287123-ldkuwcc7 472 103 of of IN cord-287123-ldkuwcc7 472 104 serum serum NN cord-287123-ldkuwcc7 472 105 amyloid amyloid NN cord-287123-ldkuwcc7 472 106 a a DT cord-287123-ldkuwcc7 472 107 - - HYPH cord-287123-ldkuwcc7 472 108 mediated mediate VBN cord-287123-ldkuwcc7 472 109 inflammatory inflammatory JJ cord-287123-ldkuwcc7 472 110 amyloidosis amyloidosis NN cord-287123-ldkuwcc7 473 1 Amyloid amyloid NN cord-287123-ldkuwcc7 474 1 ( ( -LRB- cord-287123-ldkuwcc7 474 2 beta)42 beta)42 NNP cord-287123-ldkuwcc7 474 3 activates activate VBZ cord-287123-ldkuwcc7 474 4 a a DT cord-287123-ldkuwcc7 474 5 g g NN cord-287123-ldkuwcc7 474 6 - - HYPH cord-287123-ldkuwcc7 474 7 protein protein NN cord-287123-ldkuwcc7 474 8 - - HYPH cord-287123-ldkuwcc7 474 9 coupled couple VBN cord-287123-ldkuwcc7 474 10 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 474 11 receptor receptor NN cord-287123-ldkuwcc7 474 12 , , , cord-287123-ldkuwcc7 474 13 fpr fpr NN cord-287123-ldkuwcc7 474 14 - - HYPH cord-287123-ldkuwcc7 474 15 like-1 like-1 NNP cord-287123-ldkuwcc7 474 16 Endogenous endogenous JJ cord-287123-ldkuwcc7 474 17 lipid lipid NN cord-287123-ldkuwcc7 474 18 - - HYPH cord-287123-ldkuwcc7 474 19 and and CC cord-287123-ldkuwcc7 474 20 peptide peptide NN cord-287123-ldkuwcc7 474 21 - - HYPH cord-287123-ldkuwcc7 474 22 derived derive VBN cord-287123-ldkuwcc7 474 23 anti anti JJ cord-287123-ldkuwcc7 474 24 - - JJ cord-287123-ldkuwcc7 474 25 inflammatory inflammatory JJ cord-287123-ldkuwcc7 474 26 pathways pathway NNS cord-287123-ldkuwcc7 474 27 generated generate VBN cord-287123-ldkuwcc7 474 28 with with IN cord-287123-ldkuwcc7 474 29 glucocorticoid glucocorticoid NN cord-287123-ldkuwcc7 474 30 and and CC cord-287123-ldkuwcc7 474 31 aspirin aspirin NN cord-287123-ldkuwcc7 474 32 treatment treatment NN cord-287123-ldkuwcc7 475 1 activate activate VB cord-287123-ldkuwcc7 475 2 the the DT cord-287123-ldkuwcc7 475 3 lipoxin lipoxin NNP cord-287123-ldkuwcc7 475 4 a4 a4 NNP cord-287123-ldkuwcc7 475 5 receptor receptor NN cord-287123-ldkuwcc7 475 6 Annexin Annexin NNP cord-287123-ldkuwcc7 475 7 1 1 CD cord-287123-ldkuwcc7 475 8 and and CC cord-287123-ldkuwcc7 476 1 its -PRON- PRP$ cord-287123-ldkuwcc7 476 2 bioactive bioactive JJ cord-287123-ldkuwcc7 476 3 peptide peptide NN cord-287123-ldkuwcc7 476 4 inhibit inhibit VBP cord-287123-ldkuwcc7 476 5 neutrophil neutrophil NN cord-287123-ldkuwcc7 476 6 - - HYPH cord-287123-ldkuwcc7 476 7 endothelium endothelium NN cord-287123-ldkuwcc7 476 8 interactions interaction NNS cord-287123-ldkuwcc7 476 9 under under IN cord-287123-ldkuwcc7 476 10 flow flow NN cord-287123-ldkuwcc7 476 11 : : : cord-287123-ldkuwcc7 477 1 Indication indication NN cord-287123-ldkuwcc7 477 2 of of IN cord-287123-ldkuwcc7 477 3 distinct distinct JJ cord-287123-ldkuwcc7 477 4 receptor receptor NN cord-287123-ldkuwcc7 477 5 involvement involvement NN cord-287123-ldkuwcc7 477 6 Ll-37 Ll-37 NNP cord-287123-ldkuwcc7 477 7 , , , cord-287123-ldkuwcc7 477 8 the the DT cord-287123-ldkuwcc7 477 9 neutrophil neutrophil NN cord-287123-ldkuwcc7 477 10 granule granule NN cord-287123-ldkuwcc7 477 11 - - : cord-287123-ldkuwcc7 477 12 and and CC cord-287123-ldkuwcc7 477 13 epithelial epithelial JJ cord-287123-ldkuwcc7 477 14 cell cell NN cord-287123-ldkuwcc7 477 15 - - HYPH cord-287123-ldkuwcc7 477 16 derived derive VBN cord-287123-ldkuwcc7 477 17 cathelicidin cathelicidin NNS cord-287123-ldkuwcc7 477 18 , , , cord-287123-ldkuwcc7 477 19 utilizes utilize VBZ cord-287123-ldkuwcc7 477 20 formyl formyl NNP cord-287123-ldkuwcc7 477 21 peptide peptide JJ cord-287123-ldkuwcc7 477 22 receptor receptor NN cord-287123-ldkuwcc7 477 23 - - HYPH cord-287123-ldkuwcc7 477 24 like like JJ cord-287123-ldkuwcc7 477 25 1 1 CD cord-287123-ldkuwcc7 477 26 ( ( -LRB- cord-287123-ldkuwcc7 477 27 fprl1 fprl1 NN cord-287123-ldkuwcc7 477 28 ) ) -RRB- cord-287123-ldkuwcc7 477 29 as as IN cord-287123-ldkuwcc7 477 30 a a DT cord-287123-ldkuwcc7 477 31 receptor receptor NN cord-287123-ldkuwcc7 477 32 to to TO cord-287123-ldkuwcc7 477 33 chemoattract chemoattract VB cord-287123-ldkuwcc7 477 34 human human JJ cord-287123-ldkuwcc7 477 35 peripheral peripheral JJ cord-287123-ldkuwcc7 477 36 blood blood NN cord-287123-ldkuwcc7 477 37 neutrophils neutrophil NNS cord-287123-ldkuwcc7 477 38 , , , cord-287123-ldkuwcc7 477 39 monocytes monocyte NNS cord-287123-ldkuwcc7 477 40 , , , cord-287123-ldkuwcc7 477 41 and and CC cord-287123-ldkuwcc7 477 42 t t NN cord-287123-ldkuwcc7 477 43 cells cell VBZ cord-287123-ldkuwcc7 477 44 Cross Cross NNP cord-287123-ldkuwcc7 477 45 - - NN cord-287123-ldkuwcc7 477 46 talk talk NN cord-287123-ldkuwcc7 477 47 between between IN cord-287123-ldkuwcc7 477 48 fmlp fmlp NNS cord-287123-ldkuwcc7 477 49 and and CC cord-287123-ldkuwcc7 477 50 vitronectin vitronectin NNP cord-287123-ldkuwcc7 477 51 receptors receptor NNS cord-287123-ldkuwcc7 477 52 triggered trigger VBN cord-287123-ldkuwcc7 477 53 by by IN cord-287123-ldkuwcc7 477 54 urokinase urokinase NN cord-287123-ldkuwcc7 477 55 receptor receptor NN cord-287123-ldkuwcc7 477 56 - - HYPH cord-287123-ldkuwcc7 477 57 derived derive VBN cord-287123-ldkuwcc7 477 58 srsry srsry NN cord-287123-ldkuwcc7 477 59 peptide peptide NN cord-287123-ldkuwcc7 477 60 Urokinase Urokinase NNP cord-287123-ldkuwcc7 477 61 induces induce VBZ cord-287123-ldkuwcc7 477 62 basophil basophil NNP cord-287123-ldkuwcc7 477 63 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 477 64 through through IN cord-287123-ldkuwcc7 477 65 a a DT cord-287123-ldkuwcc7 477 66 urokinase urokinase NN cord-287123-ldkuwcc7 477 67 receptor receptor NN cord-287123-ldkuwcc7 477 68 epitope epitope NN cord-287123-ldkuwcc7 477 69 that that WDT cord-287123-ldkuwcc7 477 70 is be VBZ cord-287123-ldkuwcc7 477 71 an an DT cord-287123-ldkuwcc7 477 72 endogenous endogenous JJ cord-287123-ldkuwcc7 477 73 ligand ligand NN cord-287123-ldkuwcc7 477 74 for for IN cord-287123-ldkuwcc7 477 75 formyl formyl NNP cord-287123-ldkuwcc7 477 76 peptide peptide NN cord-287123-ldkuwcc7 477 77 receptor receptor NN cord-287123-ldkuwcc7 477 78 - - HYPH cord-287123-ldkuwcc7 477 79 like like JJ cord-287123-ldkuwcc7 477 80 1 1 CD cord-287123-ldkuwcc7 477 81 and and CC cord-287123-ldkuwcc7 477 82 -like -like CD cord-287123-ldkuwcc7 477 83 2 2 CD cord-287123-ldkuwcc7 478 1 The the DT cord-287123-ldkuwcc7 478 2 neurotoxic neurotoxic JJ cord-287123-ldkuwcc7 478 3 prion prion NN cord-287123-ldkuwcc7 478 4 peptide peptide NN cord-287123-ldkuwcc7 478 5 fragment fragment NN cord-287123-ldkuwcc7 478 6 prp(106 prp(106 NNP cord-287123-ldkuwcc7 478 7 - - HYPH cord-287123-ldkuwcc7 478 8 126 126 CD cord-287123-ldkuwcc7 478 9 ) ) -RRB- cord-287123-ldkuwcc7 478 10 is be VBZ cord-287123-ldkuwcc7 478 11 a a DT cord-287123-ldkuwcc7 478 12 chemotactic chemotactic JJ cord-287123-ldkuwcc7 478 13 agonist agonist NN cord-287123-ldkuwcc7 478 14 for for IN cord-287123-ldkuwcc7 478 15 the the DT cord-287123-ldkuwcc7 478 16 g g NNP cord-287123-ldkuwcc7 478 17 protein protein NN cord-287123-ldkuwcc7 478 18 - - HYPH cord-287123-ldkuwcc7 478 19 coupled couple VBN cord-287123-ldkuwcc7 478 20 receptor receptor NN cord-287123-ldkuwcc7 478 21 formyl formyl NNP cord-287123-ldkuwcc7 478 22 peptide peptide NN cord-287123-ldkuwcc7 478 23 receptor receptor NN cord-287123-ldkuwcc7 478 24 - - HYPH cord-287123-ldkuwcc7 478 25 like like JJ cord-287123-ldkuwcc7 478 26 1 1 CD cord-287123-ldkuwcc7 478 27 Proinflammatory Proinflammatory NNP cord-287123-ldkuwcc7 478 28 proteases protease NNS cord-287123-ldkuwcc7 478 29 liberate liberate VBP cord-287123-ldkuwcc7 478 30 a a DT cord-287123-ldkuwcc7 478 31 discrete discrete JJ cord-287123-ldkuwcc7 478 32 high high JJ cord-287123-ldkuwcc7 478 33 - - HYPH cord-287123-ldkuwcc7 478 34 affinity affinity NN cord-287123-ldkuwcc7 478 35 functional functional JJ cord-287123-ldkuwcc7 478 36 fprl1 fprl1 NN cord-287123-ldkuwcc7 478 37 ( ( -LRB- cord-287123-ldkuwcc7 478 38 ccr12 ccr12 NNS cord-287123-ldkuwcc7 478 39 ) ) -RRB- cord-287123-ldkuwcc7 478 40 ligand ligand NN cord-287123-ldkuwcc7 478 41 from from IN cord-287123-ldkuwcc7 478 42 ccl23 ccl23 ADD cord-287123-ldkuwcc7 478 43 Vip Vip NNP cord-287123-ldkuwcc7 478 44 differentially differentially RB cord-287123-ldkuwcc7 478 45 activates activate VBZ cord-287123-ldkuwcc7 478 46 beta2 beta2 NN cord-287123-ldkuwcc7 478 47 integrins integrin NNS cord-287123-ldkuwcc7 478 48 , , , cord-287123-ldkuwcc7 478 49 cr1 cr1 NNP cord-287123-ldkuwcc7 478 50 , , , cord-287123-ldkuwcc7 478 51 and and CC cord-287123-ldkuwcc7 478 52 matrix matrix NN cord-287123-ldkuwcc7 478 53 metalloproteinase-9 metalloproteinase-9 NNP cord-287123-ldkuwcc7 478 54 in in IN cord-287123-ldkuwcc7 478 55 human human JJ cord-287123-ldkuwcc7 478 56 monocytes monocyte NNS cord-287123-ldkuwcc7 478 57 through through IN cord-287123-ldkuwcc7 478 58 camp/ camp/ ADD cord-287123-ldkuwcc7 479 1 pka pka NNP cord-287123-ldkuwcc7 479 2 , , , cord-287123-ldkuwcc7 479 3 epac epac NNP cord-287123-ldkuwcc7 479 4 , , , cord-287123-ldkuwcc7 479 5 and and CC cord-287123-ldkuwcc7 479 6 pi-3k pi-3k NNP cord-287123-ldkuwcc7 479 7 signaling signal VBG cord-287123-ldkuwcc7 479 8 pathways pathway NNS cord-287123-ldkuwcc7 479 9 via via IN cord-287123-ldkuwcc7 479 10 vip vip NN cord-287123-ldkuwcc7 479 11 receptor receptor NN cord-287123-ldkuwcc7 479 12 type type NN cord-287123-ldkuwcc7 479 13 1 1 CD cord-287123-ldkuwcc7 479 14 and and CC cord-287123-ldkuwcc7 479 15 fprl1 fprl1 NN cord-287123-ldkuwcc7 480 1 A a DT cord-287123-ldkuwcc7 480 2 peptide peptide NN cord-287123-ldkuwcc7 480 3 with with IN cord-287123-ldkuwcc7 480 4 unique unique JJ cord-287123-ldkuwcc7 480 5 receptor receptor NN cord-287123-ldkuwcc7 480 6 specificity specificity NN cord-287123-ldkuwcc7 480 7 : : : cord-287123-ldkuwcc7 480 8 Stimulation stimulation NN cord-287123-ldkuwcc7 480 9 of of IN cord-287123-ldkuwcc7 480 10 phosphoinositide phosphoinositide JJ cord-287123-ldkuwcc7 480 11 hydrolysis hydrolysis NN cord-287123-ldkuwcc7 480 12 and and CC cord-287123-ldkuwcc7 480 13 induction induction NN cord-287123-ldkuwcc7 480 14 of of IN cord-287123-ldkuwcc7 480 15 superoxide superoxide JJ cord-287123-ldkuwcc7 480 16 generation generation NN cord-287123-ldkuwcc7 480 17 in in IN cord-287123-ldkuwcc7 480 18 human human JJ cord-287123-ldkuwcc7 480 19 neutrophils neutrophil NNS cord-287123-ldkuwcc7 480 20 Utilization utilization NN cord-287123-ldkuwcc7 480 21 of of IN cord-287123-ldkuwcc7 480 22 two two CD cord-287123-ldkuwcc7 480 23 seven seven CD cord-287123-ldkuwcc7 480 24 - - HYPH cord-287123-ldkuwcc7 480 25 transmembrane transmembrane NN cord-287123-ldkuwcc7 480 26 , , , cord-287123-ldkuwcc7 480 27 g g NN cord-287123-ldkuwcc7 480 28 protein protein NN cord-287123-ldkuwcc7 480 29 - - HYPH cord-287123-ldkuwcc7 480 30 coupled couple VBN cord-287123-ldkuwcc7 480 31 receptors receptor NNS cord-287123-ldkuwcc7 480 32 , , , cord-287123-ldkuwcc7 480 33 formyl formyl NN cord-287123-ldkuwcc7 480 34 peptide peptide NN cord-287123-ldkuwcc7 480 35 receptor receptor NN cord-287123-ldkuwcc7 480 36 - - HYPH cord-287123-ldkuwcc7 480 37 like like JJ cord-287123-ldkuwcc7 480 38 1 1 CD cord-287123-ldkuwcc7 480 39 and and CC cord-287123-ldkuwcc7 480 40 formyl formyl NNP cord-287123-ldkuwcc7 480 41 peptide peptide NN cord-287123-ldkuwcc7 480 42 receptor receptor NN cord-287123-ldkuwcc7 480 43 , , , cord-287123-ldkuwcc7 480 44 by by IN cord-287123-ldkuwcc7 480 45 the the DT cord-287123-ldkuwcc7 480 46 synthetic synthetic JJ cord-287123-ldkuwcc7 480 47 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 480 48 wkymvm wkymvm NNP cord-287123-ldkuwcc7 480 49 for for IN cord-287123-ldkuwcc7 480 50 human human NNP cord-287123-ldkuwcc7 480 51 phagocyte phagocyte NNP cord-287123-ldkuwcc7 480 52 activation activation NN cord-287123-ldkuwcc7 481 1 The the DT cord-287123-ldkuwcc7 482 1 synthetic synthetic JJ cord-287123-ldkuwcc7 482 2 peptide peptide NN cord-287123-ldkuwcc7 482 3 trp trp NN cord-287123-ldkuwcc7 482 4 - - HYPH cord-287123-ldkuwcc7 482 5 lys lys NNP cord-287123-ldkuwcc7 482 6 - - HYPH cord-287123-ldkuwcc7 482 7 tyr tyr NNP cord-287123-ldkuwcc7 482 8 - - HYPH cord-287123-ldkuwcc7 482 9 met- met- XX cord-287123-ldkuwcc7 483 1 val val NNP cord-287123-ldkuwcc7 483 2 - - HYPH cord-287123-ldkuwcc7 483 3 met met NNP cord-287123-ldkuwcc7 483 4 - - HYPH cord-287123-ldkuwcc7 483 5 nh2 nh2 NNP cord-287123-ldkuwcc7 483 6 specifically specifically RB cord-287123-ldkuwcc7 483 7 activates activate VBZ cord-287123-ldkuwcc7 483 8 neutrophils neutrophil NNS cord-287123-ldkuwcc7 483 9 through through IN cord-287123-ldkuwcc7 483 10 fprl1 fprl1 NN cord-287123-ldkuwcc7 483 11 / / SYM cord-287123-ldkuwcc7 483 12 lipoxin lipoxin NNP cord-287123-ldkuwcc7 483 13 a4 a4 NNP cord-287123-ldkuwcc7 483 14 receptors receptor NNS cord-287123-ldkuwcc7 483 15 and and CC cord-287123-ldkuwcc7 483 16 is be VBZ cord-287123-ldkuwcc7 483 17 an an DT cord-287123-ldkuwcc7 483 18 agonist agonist NN cord-287123-ldkuwcc7 483 19 for for IN cord-287123-ldkuwcc7 483 20 the the DT cord-287123-ldkuwcc7 483 21 orphan orphan NN cord-287123-ldkuwcc7 483 22 monocyte monocyte NNP cord-287123-ldkuwcc7 483 23 - - HYPH cord-287123-ldkuwcc7 483 24 expressed express VBN cord-287123-ldkuwcc7 483 25 chemoattractant chemoattractant NN cord-287123-ldkuwcc7 483 26 receptor receptor NN cord-287123-ldkuwcc7 483 27 fprl2 fprl2 NNP cord-287123-ldkuwcc7 483 28 Identification Identification NNP cord-287123-ldkuwcc7 483 29 of of IN cord-287123-ldkuwcc7 483 30 surrogate surrogate JJ cord-287123-ldkuwcc7 483 31 agonists agonist NNS cord-287123-ldkuwcc7 483 32 for for IN cord-287123-ldkuwcc7 483 33 the the DT cord-287123-ldkuwcc7 483 34 human human NN cord-287123-ldkuwcc7 483 35 fprl-1 fprl-1 NNP cord-287123-ldkuwcc7 483 36 receptor receptor NN cord-287123-ldkuwcc7 483 37 by by IN cord-287123-ldkuwcc7 483 38 autocrine autocrine NN cord-287123-ldkuwcc7 483 39 selection selection NN cord-287123-ldkuwcc7 483 40 in in IN cord-287123-ldkuwcc7 483 41 yeast yeast NN cord-287123-ldkuwcc7 483 42 Apolipoproteins Apolipoproteins NNP cord-287123-ldkuwcc7 483 43 and and CC cord-287123-ldkuwcc7 483 44 apolipoprotein apolipoprotein NN cord-287123-ldkuwcc7 483 45 mimetic mimetic NN cord-287123-ldkuwcc7 483 46 peptides peptide NNS cord-287123-ldkuwcc7 483 47 modulate modulate VBP cord-287123-ldkuwcc7 483 48 phagocyte phagocyte NNS cord-287123-ldkuwcc7 483 49 trafficking traffic VBG cord-287123-ldkuwcc7 483 50 through through IN cord-287123-ldkuwcc7 483 51 chemotactic chemotactic JJ cord-287123-ldkuwcc7 483 52 activity activity NN cord-287123-ldkuwcc7 483 53 Activation activation NN cord-287123-ldkuwcc7 483 54 of of IN cord-287123-ldkuwcc7 483 55 human human JJ cord-287123-ldkuwcc7 483 56 monocytes monocyte NNS cord-287123-ldkuwcc7 483 57 by by IN cord-287123-ldkuwcc7 483 58 a a DT cord-287123-ldkuwcc7 483 59 formyl formyl NNP cord-287123-ldkuwcc7 483 60 peptide peptide NN cord-287123-ldkuwcc7 483 61 receptor receptor NN cord-287123-ldkuwcc7 483 62 2-derived 2-derived CD cord-287123-ldkuwcc7 483 63 pepducin pepducin NNS cord-287123-ldkuwcc7 483 64 The the DT cord-287123-ldkuwcc7 483 65 leukocyte leukocyte NN cord-287123-ldkuwcc7 483 66 chemotactic chemotactic JJ cord-287123-ldkuwcc7 483 67 receptor receptor NN cord-287123-ldkuwcc7 483 68 fpr2 fpr2 NN cord-287123-ldkuwcc7 483 69 , , , cord-287123-ldkuwcc7 483 70 but but CC cord-287123-ldkuwcc7 483 71 not not RB cord-287123-ldkuwcc7 483 72 the the DT cord-287123-ldkuwcc7 483 73 closely closely RB cord-287123-ldkuwcc7 483 74 related related JJ cord-287123-ldkuwcc7 483 75 fpr1 fpr1 NN cord-287123-ldkuwcc7 483 76 , , , cord-287123-ldkuwcc7 483 77 is be VBZ cord-287123-ldkuwcc7 483 78 sensitive sensitive JJ cord-287123-ldkuwcc7 483 79 to to IN cord-287123-ldkuwcc7 483 80 cell cell NN cord-287123-ldkuwcc7 483 81 - - HYPH cord-287123-ldkuwcc7 483 82 penetrating penetrate VBG cord-287123-ldkuwcc7 483 83 pepducins pepducin NNS cord-287123-ldkuwcc7 483 84 with with IN cord-287123-ldkuwcc7 483 85 amino amino NN cord-287123-ldkuwcc7 483 86 acid acid NN cord-287123-ldkuwcc7 483 87 sequences sequence NNS cord-287123-ldkuwcc7 483 88 descending descend VBG cord-287123-ldkuwcc7 483 89 from from IN cord-287123-ldkuwcc7 483 90 the the DT cord-287123-ldkuwcc7 483 91 third third JJ cord-287123-ldkuwcc7 483 92 intracellular intracellular JJ cord-287123-ldkuwcc7 483 93 receptor receptor NN cord-287123-ldkuwcc7 483 94 loop loop NN cord-287123-ldkuwcc7 483 95 Identification identification NN cord-287123-ldkuwcc7 483 96 of of IN cord-287123-ldkuwcc7 483 97 a a DT cord-287123-ldkuwcc7 483 98 human human JJ cord-287123-ldkuwcc7 483 99 cdna cdna NN cord-287123-ldkuwcc7 483 100 encoding encode VBG cord-287123-ldkuwcc7 483 101 a a DT cord-287123-ldkuwcc7 483 102 functional functional JJ cord-287123-ldkuwcc7 483 103 high high JJ cord-287123-ldkuwcc7 483 104 affinity affinity NN cord-287123-ldkuwcc7 483 105 lipoxin lipoxin NNP cord-287123-ldkuwcc7 483 106 a4 a4 NNP cord-287123-ldkuwcc7 483 107 receptor receptor NNP cord-287123-ldkuwcc7 483 108 A a DT cord-287123-ldkuwcc7 483 109 novel novel NN cord-287123-ldkuwcc7 483 110 nonpeptide nonpeptide NN cord-287123-ldkuwcc7 483 111 ligand ligand NNP cord-287123-ldkuwcc7 483 112 for for IN cord-287123-ldkuwcc7 483 113 formyl formyl NNP cord-287123-ldkuwcc7 483 114 peptide peptide NN cord-287123-ldkuwcc7 483 115 receptor receptor NN cord-287123-ldkuwcc7 483 116 - - HYPH cord-287123-ldkuwcc7 483 117 like like JJ cord-287123-ldkuwcc7 484 1 1 1 CD cord-287123-ldkuwcc7 484 2 Identification identification NN cord-287123-ldkuwcc7 484 3 of of IN cord-287123-ldkuwcc7 484 4 novel novel JJ cord-287123-ldkuwcc7 484 5 small small JJ cord-287123-ldkuwcc7 484 6 - - HYPH cord-287123-ldkuwcc7 484 7 molecule molecule NN cord-287123-ldkuwcc7 484 8 agonists agonist NNS cord-287123-ldkuwcc7 484 9 for for IN cord-287123-ldkuwcc7 484 10 human human JJ cord-287123-ldkuwcc7 484 11 formyl formyl NNP cord-287123-ldkuwcc7 484 12 peptide peptide NN cord-287123-ldkuwcc7 484 13 receptors receptor NNS cord-287123-ldkuwcc7 484 14 and and CC cord-287123-ldkuwcc7 484 15 pharmacophore pharmacophore NN cord-287123-ldkuwcc7 484 16 models model NNS cord-287123-ldkuwcc7 484 17 of of IN cord-287123-ldkuwcc7 484 18 their -PRON- PRP$ cord-287123-ldkuwcc7 484 19 recognition recognition NN cord-287123-ldkuwcc7 484 20 New New NNP cord-287123-ldkuwcc7 484 21 ' ' '' cord-287123-ldkuwcc7 484 22 chemical chemical NN cord-287123-ldkuwcc7 484 23 probes probe NNS cord-287123-ldkuwcc7 484 24 ' ' '' cord-287123-ldkuwcc7 485 1 to to TO cord-287123-ldkuwcc7 485 2 examine examine VB cord-287123-ldkuwcc7 485 3 the the DT cord-287123-ldkuwcc7 485 4 role role NN cord-287123-ldkuwcc7 485 5 of of IN cord-287123-ldkuwcc7 485 6 the the DT cord-287123-ldkuwcc7 485 7 hfprl1 hfprl1 NNP cord-287123-ldkuwcc7 485 8 ( ( -LRB- cord-287123-ldkuwcc7 485 9 or or CC cord-287123-ldkuwcc7 485 10 alxr alxr NNP cord-287123-ldkuwcc7 485 11 ) ) -RRB- cord-287123-ldkuwcc7 485 12 receptor receptor NN cord-287123-ldkuwcc7 485 13 in in IN cord-287123-ldkuwcc7 485 14 inflammation inflammation NN cord-287123-ldkuwcc7 486 1 Potent potent JJ cord-287123-ldkuwcc7 486 2 hfprl1 hfprl1 NN cord-287123-ldkuwcc7 487 1 ( ( -LRB- cord-287123-ldkuwcc7 487 2 alxr alxr NNP cord-287123-ldkuwcc7 487 3 ) ) -RRB- cord-287123-ldkuwcc7 487 4 agonists agonist NNS cord-287123-ldkuwcc7 487 5 as as IN cord-287123-ldkuwcc7 487 6 potential potential JJ cord-287123-ldkuwcc7 487 7 anti anti JJ cord-287123-ldkuwcc7 487 8 - - JJ cord-287123-ldkuwcc7 487 9 inflammatory inflammatory JJ cord-287123-ldkuwcc7 487 10 agents agent NNS cord-287123-ldkuwcc7 487 11 Formyl Formyl NNP cord-287123-ldkuwcc7 487 12 peptide peptide NN cord-287123-ldkuwcc7 487 13 receptor receptor NN cord-287123-ldkuwcc7 487 14 1 1 CD cord-287123-ldkuwcc7 487 15 and and CC cord-287123-ldkuwcc7 487 16 2 2 CD cord-287123-ldkuwcc7 487 17 dual dual JJ cord-287123-ldkuwcc7 487 18 agonist agonist NN cord-287123-ldkuwcc7 487 19 inhibits inhibit VBZ cord-287123-ldkuwcc7 487 20 human human JJ cord-287123-ldkuwcc7 487 21 neutrophil neutrophil NN cord-287123-ldkuwcc7 487 22 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 487 23 by by IN cord-287123-ldkuwcc7 487 24 the the DT cord-287123-ldkuwcc7 487 25 induction induction NN cord-287123-ldkuwcc7 487 26 of of IN cord-287123-ldkuwcc7 487 27 chemoattractant chemoattractant NNP cord-287123-ldkuwcc7 487 28 receptor receptor NNP cord-287123-ldkuwcc7 487 29 cross cross NNP cord-287123-ldkuwcc7 487 30 - - JJ cord-287123-ldkuwcc7 487 31 desensitization desensitization JJ cord-287123-ldkuwcc7 487 32 Synthesis Synthesis NNP cord-287123-ldkuwcc7 487 33 and and CC cord-287123-ldkuwcc7 487 34 pharmacological pharmacological JJ cord-287123-ldkuwcc7 487 35 evaluation evaluation NN cord-287123-ldkuwcc7 487 36 of of IN cord-287123-ldkuwcc7 487 37 new new JJ cord-287123-ldkuwcc7 487 38 pyridazin pyridazin NNP cord-287123-ldkuwcc7 487 39 - - HYPH cord-287123-ldkuwcc7 487 40 based base VBN cord-287123-ldkuwcc7 487 41 thioderivatives thioderivative NNS cord-287123-ldkuwcc7 487 42 as as IN cord-287123-ldkuwcc7 487 43 formyl formyl NNP cord-287123-ldkuwcc7 487 44 peptide peptide NN cord-287123-ldkuwcc7 487 45 receptor receptor NN cord-287123-ldkuwcc7 487 46 ( ( -LRB- cord-287123-ldkuwcc7 487 47 fpr fpr NNP cord-287123-ldkuwcc7 487 48 ) ) -RRB- cord-287123-ldkuwcc7 487 49 agonists agonist NNS cord-287123-ldkuwcc7 487 50 Synthesis Synthesis NNP cord-287123-ldkuwcc7 487 51 , , , cord-287123-ldkuwcc7 487 52 enantioresolution enantioresolution NN cord-287123-ldkuwcc7 487 53 , , , cord-287123-ldkuwcc7 487 54 and and CC cord-287123-ldkuwcc7 487 55 activity activity NN cord-287123-ldkuwcc7 487 56 profile profile NN cord-287123-ldkuwcc7 487 57 of of IN cord-287123-ldkuwcc7 487 58 chiral chiral JJ cord-287123-ldkuwcc7 487 59 6-methyl-2,4-disubstituted 6-methyl-2,4-disubstituted NNP cord-287123-ldkuwcc7 487 60 pyridazin-3(2h)-ones pyridazin-3(2h)-one NNS cord-287123-ldkuwcc7 487 61 as as IN cord-287123-ldkuwcc7 487 62 potent potent JJ cord-287123-ldkuwcc7 487 63 n n NNP cord-287123-ldkuwcc7 487 64 - - HYPH cord-287123-ldkuwcc7 487 65 formyl formyl NNP cord-287123-ldkuwcc7 487 66 peptide peptide NN cord-287123-ldkuwcc7 487 67 receptor receptor NN cord-287123-ldkuwcc7 487 68 agonists agonist NNS cord-287123-ldkuwcc7 487 69 3-(1h 3-(1h CD cord-287123-ldkuwcc7 487 70 - - HYPH cord-287123-ldkuwcc7 487 71 indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide NN cord-287123-ldkuwcc7 487 72 enantiomers enantiomer NNS cord-287123-ldkuwcc7 487 73 with with IN cord-287123-ldkuwcc7 487 74 human human JJ cord-287123-ldkuwcc7 487 75 formyl formyl NN cord-287123-ldkuwcc7 487 76 - - HYPH cord-287123-ldkuwcc7 487 77 peptide peptide NN cord-287123-ldkuwcc7 487 78 receptor receptor NN cord-287123-ldkuwcc7 487 79 agonist agonist NN cord-287123-ldkuwcc7 487 80 activity activity NN cord-287123-ldkuwcc7 487 81 : : : cord-287123-ldkuwcc7 487 82 Molecular molecular JJ cord-287123-ldkuwcc7 487 83 modeling modeling NN cord-287123-ldkuwcc7 487 84 of of IN cord-287123-ldkuwcc7 487 85 chiral chiral JJ cord-287123-ldkuwcc7 487 86 recognition recognition NN cord-287123-ldkuwcc7 487 87 by by IN cord-287123-ldkuwcc7 487 88 fpr2 fpr2 NNP cord-287123-ldkuwcc7 487 89 Novel Novel NNP cord-287123-ldkuwcc7 487 90 3-(1h 3-(1h NNP cord-287123-ldkuwcc7 487 91 - - HYPH cord-287123-ldkuwcc7 487 92 indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamide NNS cord-287123-ldkuwcc7 487 93 as as IN cord-287123-ldkuwcc7 487 94 selective selective JJ cord-287123-ldkuwcc7 487 95 agonists agonist NNS cord-287123-ldkuwcc7 487 96 of of IN cord-287123-ldkuwcc7 487 97 human human JJ cord-287123-ldkuwcc7 487 98 formyl formyl NNP cord-287123-ldkuwcc7 487 99 - - HYPH cord-287123-ldkuwcc7 487 100 peptide peptide NN cord-287123-ldkuwcc7 487 101 receptor receptor NN cord-287123-ldkuwcc7 487 102 2 2 CD cord-287123-ldkuwcc7 487 103 Selective selective JJ cord-287123-ldkuwcc7 487 104 agonists agonist NNS cord-287123-ldkuwcc7 487 105 and and CC cord-287123-ldkuwcc7 487 106 antagonists antagonist NNS cord-287123-ldkuwcc7 487 107 of of IN cord-287123-ldkuwcc7 487 108 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 487 109 receptors receptor NNS cord-287123-ldkuwcc7 487 110 : : : cord-287123-ldkuwcc7 488 1 Duplex duplex JJ cord-287123-ldkuwcc7 488 2 flow flow NN cord-287123-ldkuwcc7 488 3 cytometry cytometry NN cord-287123-ldkuwcc7 488 4 and and CC cord-287123-ldkuwcc7 488 5 mixture mixture NN cord-287123-ldkuwcc7 488 6 - - HYPH cord-287123-ldkuwcc7 488 7 based base VBN cord-287123-ldkuwcc7 488 8 positional positional JJ cord-287123-ldkuwcc7 488 9 scanning scanning NN cord-287123-ldkuwcc7 488 10 libraries library NNS cord-287123-ldkuwcc7 488 11 N n CD cord-287123-ldkuwcc7 488 12 - - HYPH cord-287123-ldkuwcc7 488 13 terminal terminal NN cord-287123-ldkuwcc7 488 14 residues residue NNS cord-287123-ldkuwcc7 488 15 of of IN cord-287123-ldkuwcc7 488 16 the the DT cord-287123-ldkuwcc7 488 17 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 488 18 inhibitory inhibitory JJ cord-287123-ldkuwcc7 488 19 protein protein NN cord-287123-ldkuwcc7 488 20 of of IN cord-287123-ldkuwcc7 488 21 staphylococcus staphylococcus NN cord-287123-ldkuwcc7 488 22 aureus aureus NN cord-287123-ldkuwcc7 488 23 are be VBP cord-287123-ldkuwcc7 488 24 essential essential JJ cord-287123-ldkuwcc7 488 25 for for IN cord-287123-ldkuwcc7 488 26 blocking block VBG cord-287123-ldkuwcc7 488 27 formylated formylated JJ cord-287123-ldkuwcc7 488 28 peptide peptide JJ cord-287123-ldkuwcc7 488 29 receptor receptor NN cord-287123-ldkuwcc7 488 30 but but CC cord-287123-ldkuwcc7 489 1 not not RB cord-287123-ldkuwcc7 489 2 c5a c5a JJ cord-287123-ldkuwcc7 489 3 receptor receptor NN cord-287123-ldkuwcc7 490 1 Uteroglobin Uteroglobin NNP cord-287123-ldkuwcc7 490 2 suppresses suppress VBZ cord-287123-ldkuwcc7 490 3 allergen allergen NN cord-287123-ldkuwcc7 490 4 - - HYPH cord-287123-ldkuwcc7 490 5 induced induce VBN cord-287123-ldkuwcc7 490 6 th2 th2 NNP cord-287123-ldkuwcc7 490 7 differentiation differentiation NN cord-287123-ldkuwcc7 490 8 by by IN cord-287123-ldkuwcc7 490 9 down down NN cord-287123-ldkuwcc7 490 10 - - HYPH cord-287123-ldkuwcc7 490 11 regulating regulate VBG cord-287123-ldkuwcc7 490 12 the the DT cord-287123-ldkuwcc7 490 13 expression expression NN cord-287123-ldkuwcc7 490 14 of of IN cord-287123-ldkuwcc7 490 15 serum serum NN cord-287123-ldkuwcc7 490 16 amyloid amyloid NN cord-287123-ldkuwcc7 490 17 a a DT cord-287123-ldkuwcc7 490 18 and and CC cord-287123-ldkuwcc7 490 19 socs-3 socs-3 NNP cord-287123-ldkuwcc7 490 20 genes gene NNS cord-287123-ldkuwcc7 490 21 Cyclosporin Cyclosporin NNP cord-287123-ldkuwcc7 490 22 h h NNP cord-287123-ldkuwcc7 490 23 is be VBZ cord-287123-ldkuwcc7 490 24 a a DT cord-287123-ldkuwcc7 490 25 potent potent JJ cord-287123-ldkuwcc7 490 26 and and CC cord-287123-ldkuwcc7 490 27 selective selective JJ cord-287123-ldkuwcc7 490 28 formyl formyl NN cord-287123-ldkuwcc7 490 29 peptide peptide NN cord-287123-ldkuwcc7 490 30 receptor receptor NN cord-287123-ldkuwcc7 490 31 antagonist antagonist NN cord-287123-ldkuwcc7 490 32 . . . cord-287123-ldkuwcc7 491 1 Comparison comparison NN cord-287123-ldkuwcc7 491 2 with with IN cord-287123-ldkuwcc7 491 3 n n JJ cord-287123-ldkuwcc7 491 4 - - HYPH cord-287123-ldkuwcc7 491 5 t t NN cord-287123-ldkuwcc7 491 6 - - HYPH cord-287123-ldkuwcc7 491 7 butoxycarbonyl butoxycarbonyl NNP cord-287123-ldkuwcc7 491 8 - - HYPH cord-287123-ldkuwcc7 491 9 l l NN cord-287123-ldkuwcc7 491 10 - - HYPH cord-287123-ldkuwcc7 491 11 phenylalanyl phenylalanyl JJ cord-287123-ldkuwcc7 491 12 - - HYPH cord-287123-ldkuwcc7 491 13 l l NN cord-287123-ldkuwcc7 491 14 - - HYPH cord-287123-ldkuwcc7 491 15 leucyl leucyl NNP cord-287123-ldkuwcc7 491 16 - - HYPH cord-287123-ldkuwcc7 491 17 l l NN cord-287123-ldkuwcc7 491 18 - - HYPH cord-287123-ldkuwcc7 491 19 phenylalanyl phenylalanyl JJ cord-287123-ldkuwcc7 491 20 - - HYPH cord-287123-ldkuwcc7 491 21 l l NN cord-287123-ldkuwcc7 491 22 - - HYPH cord-287123-ldkuwcc7 491 23 leucyl leucyl NNP cord-287123-ldkuwcc7 491 24 - - HYPH cord-287123-ldkuwcc7 491 25 l l NN cord-287123-ldkuwcc7 491 26 - - HYPH cord-287123-ldkuwcc7 491 27 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 491 28 and and CC cord-287123-ldkuwcc7 491 29 cyclosporins cyclosporins NNP cord-287123-ldkuwcc7 491 30 a a NNP cord-287123-ldkuwcc7 491 31 , , , cord-287123-ldkuwcc7 491 32 b b NNP cord-287123-ldkuwcc7 491 33 , , , cord-287123-ldkuwcc7 491 34 c c NNP cord-287123-ldkuwcc7 491 35 , , , cord-287123-ldkuwcc7 491 36 d d NNP cord-287123-ldkuwcc7 491 37 , , , cord-287123-ldkuwcc7 491 38 and and CC cord-287123-ldkuwcc7 491 39 e e LS cord-287123-ldkuwcc7 491 40 Cyclization Cyclization NNP cord-287123-ldkuwcc7 491 41 of of IN cord-287123-ldkuwcc7 491 42 the the DT cord-287123-ldkuwcc7 491 43 urokinase urokinase NN cord-287123-ldkuwcc7 491 44 receptor receptor NN cord-287123-ldkuwcc7 491 45 - - HYPH cord-287123-ldkuwcc7 491 46 derived derive VBN cord-287123-ldkuwcc7 491 47 ser ser JJ cord-287123-ldkuwcc7 491 48 - - HYPH cord-287123-ldkuwcc7 491 49 arg arg JJ cord-287123-ldkuwcc7 491 50 - - HYPH cord-287123-ldkuwcc7 491 51 ser ser JJ cord-287123-ldkuwcc7 491 52 - - HYPH cord-287123-ldkuwcc7 491 53 arg arg JJ cord-287123-ldkuwcc7 491 54 - - HYPH cord-287123-ldkuwcc7 491 55 tyr tyr NN cord-287123-ldkuwcc7 491 56 peptide peptide NN cord-287123-ldkuwcc7 491 57 generates generate VBZ cord-287123-ldkuwcc7 491 58 a a DT cord-287123-ldkuwcc7 491 59 potent potent JJ cord-287123-ldkuwcc7 491 60 inhibitor inhibitor NN cord-287123-ldkuwcc7 491 61 of of IN cord-287123-ldkuwcc7 491 62 trans trans JJ cord-287123-ldkuwcc7 491 63 - - JJ cord-287123-ldkuwcc7 491 64 endothelial endothelial JJ cord-287123-ldkuwcc7 491 65 migration migration NN cord-287123-ldkuwcc7 491 66 of of IN cord-287123-ldkuwcc7 491 67 monocytes monocyte NNS cord-287123-ldkuwcc7 491 68 Identification identification NN cord-287123-ldkuwcc7 491 69 of of IN cord-287123-ldkuwcc7 491 70 peptides peptide NNS cord-287123-ldkuwcc7 491 71 that that WDT cord-287123-ldkuwcc7 491 72 antagonize antagonize VBP cord-287123-ldkuwcc7 491 73 formyl formyl NNP cord-287123-ldkuwcc7 491 74 peptide peptide JJ cord-287123-ldkuwcc7 491 75 receptor receptor NN cord-287123-ldkuwcc7 491 76 - - HYPH cord-287123-ldkuwcc7 491 77 like like JJ cord-287123-ldkuwcc7 492 1 1-mediated 1-mediated CD cord-287123-ldkuwcc7 492 2 signaling signal VBG cord-287123-ldkuwcc7 492 3 Structural structural JJ cord-287123-ldkuwcc7 492 4 characterization characterization NN cord-287123-ldkuwcc7 492 5 and and CC cord-287123-ldkuwcc7 492 6 inhibitory inhibitory JJ cord-287123-ldkuwcc7 492 7 profile profile NN cord-287123-ldkuwcc7 492 8 of of IN cord-287123-ldkuwcc7 492 9 formyl formyl NNP cord-287123-ldkuwcc7 492 10 peptide peptide NN cord-287123-ldkuwcc7 492 11 receptor receptor NN cord-287123-ldkuwcc7 492 12 2 2 CD cord-287123-ldkuwcc7 492 13 selective selective JJ cord-287123-ldkuwcc7 492 14 peptides peptide NNS cord-287123-ldkuwcc7 492 15 descending descend VBG cord-287123-ldkuwcc7 492 16 from from IN cord-287123-ldkuwcc7 492 17 a a DT cord-287123-ldkuwcc7 492 18 pip2-binding pip2-binding NNP cord-287123-ldkuwcc7 492 19 domain domain NN cord-287123-ldkuwcc7 492 20 of of IN cord-287123-ldkuwcc7 492 21 gelsolin gelsolin NN cord-287123-ldkuwcc7 492 22 A a DT cord-287123-ldkuwcc7 492 23 neutrophil neutrophil NN cord-287123-ldkuwcc7 492 24 inhibitory inhibitory JJ cord-287123-ldkuwcc7 492 25 pepducin pepducin NNS cord-287123-ldkuwcc7 492 26 derived derive VBN cord-287123-ldkuwcc7 492 27 from from IN cord-287123-ldkuwcc7 492 28 fpr1 fpr1 NN cord-287123-ldkuwcc7 492 29 expected expect VBN cord-287123-ldkuwcc7 492 30 to to TO cord-287123-ldkuwcc7 492 31 target target VB cord-287123-ldkuwcc7 492 32 fpr1 fpr1 NN cord-287123-ldkuwcc7 492 33 signaling signal VBG cord-287123-ldkuwcc7 492 34 hijacks hijack VBZ cord-287123-ldkuwcc7 492 35 the the DT cord-287123-ldkuwcc7 492 36 closely closely RB cord-287123-ldkuwcc7 492 37 related relate VBN cord-287123-ldkuwcc7 492 38 fpr2 fpr2 NNP cord-287123-ldkuwcc7 493 1 instead instead RB cord-287123-ldkuwcc7 493 2 The the DT cord-287123-ldkuwcc7 493 3 proteolytically proteolytically RB cord-287123-ldkuwcc7 493 4 stable stable JJ cord-287123-ldkuwcc7 493 5 peptidomimetic peptidomimetic JJ cord-287123-ldkuwcc7 493 6 pam-(lys pam-(lys NN cord-287123-ldkuwcc7 493 7 - - HYPH cord-287123-ldkuwcc7 493 8 betanspe)6-nh2 betanspe)6-nh2 JJ cord-287123-ldkuwcc7 493 9 selectively selectively RB cord-287123-ldkuwcc7 493 10 inhibits inhibit VBZ cord-287123-ldkuwcc7 493 11 human human JJ cord-287123-ldkuwcc7 493 12 neutrophil neutrophil NN cord-287123-ldkuwcc7 493 13 activation activation NN cord-287123-ldkuwcc7 493 14 via via IN cord-287123-ldkuwcc7 493 15 formyl formyl NNP cord-287123-ldkuwcc7 493 16 peptide peptide NN cord-287123-ldkuwcc7 493 17 receptor receptor NN cord-287123-ldkuwcc7 493 18 2 2 CD cord-287123-ldkuwcc7 494 1 The the DT cord-287123-ldkuwcc7 494 2 peptidomimetic peptidomimetic JJ cord-287123-ldkuwcc7 494 3 lau-(lys lau-(lys NNP cord-287123-ldkuwcc7 494 4 - - HYPH cord-287123-ldkuwcc7 494 5 betanspe)6-nh2 betanspe)6-nh2 CD cord-287123-ldkuwcc7 494 6 antagonizes antagonize VBZ cord-287123-ldkuwcc7 494 7 formyl formyl NNP cord-287123-ldkuwcc7 494 8 peptide peptide NN cord-287123-ldkuwcc7 494 9 receptor receptor NN cord-287123-ldkuwcc7 494 10 2 2 CD cord-287123-ldkuwcc7 494 11 expressed express VBN cord-287123-ldkuwcc7 494 12 in in IN cord-287123-ldkuwcc7 494 13 mouse mouse NN cord-287123-ldkuwcc7 494 14 neutrophils neutrophil NNS cord-287123-ldkuwcc7 494 15 Antagonism antagonism NN cord-287123-ldkuwcc7 494 16 of of IN cord-287123-ldkuwcc7 494 17 human human NNP cord-287123-ldkuwcc7 494 18 formyl formyl NNP cord-287123-ldkuwcc7 494 19 peptide peptide NN cord-287123-ldkuwcc7 494 20 receptor receptor NN cord-287123-ldkuwcc7 494 21 1 1 CD cord-287123-ldkuwcc7 494 22 ( ( -LRB- cord-287123-ldkuwcc7 494 23 fpr1 fpr1 NN cord-287123-ldkuwcc7 494 24 ) ) -RRB- cord-287123-ldkuwcc7 494 25 by by IN cord-287123-ldkuwcc7 494 26 chromones chromone NNS cord-287123-ldkuwcc7 494 27 and and CC cord-287123-ldkuwcc7 494 28 related relate VBN cord-287123-ldkuwcc7 494 29 isoflavones isoflavone NNS cord-287123-ldkuwcc7 494 30 Pharmacological pharmacological JJ cord-287123-ldkuwcc7 494 31 characterization characterization NN cord-287123-ldkuwcc7 494 32 of of IN cord-287123-ldkuwcc7 494 33 a a DT cord-287123-ldkuwcc7 494 34 novel novel JJ cord-287123-ldkuwcc7 494 35 nonpeptide nonpeptide NN cord-287123-ldkuwcc7 494 36 antagonist antagonist NN cord-287123-ldkuwcc7 494 37 for for IN cord-287123-ldkuwcc7 494 38 formyl formyl NNP cord-287123-ldkuwcc7 494 39 peptide peptide NN cord-287123-ldkuwcc7 494 40 receptor receptor NN cord-287123-ldkuwcc7 494 41 - - HYPH cord-287123-ldkuwcc7 494 42 like like JJ cord-287123-ldkuwcc7 494 43 1 1 CD cord-287123-ldkuwcc7 494 44 Structural structural JJ cord-287123-ldkuwcc7 494 45 determinants determinant NNS cord-287123-ldkuwcc7 494 46 for for IN cord-287123-ldkuwcc7 494 47 the the DT cord-287123-ldkuwcc7 494 48 interaction interaction NN cord-287123-ldkuwcc7 494 49 of of IN cord-287123-ldkuwcc7 494 50 formyl formyl NNP cord-287123-ldkuwcc7 494 51 peptide peptide NN cord-287123-ldkuwcc7 494 52 receptor receptor NN cord-287123-ldkuwcc7 494 53 2 2 CD cord-287123-ldkuwcc7 494 54 with with IN cord-287123-ldkuwcc7 494 55 peptide peptide NN cord-287123-ldkuwcc7 494 56 ligands ligand NNS cord-287123-ldkuwcc7 494 57 Community Community NNP cord-287123-ldkuwcc7 494 58 - - HYPH cord-287123-ldkuwcc7 494 59 associated associate VBN cord-287123-ldkuwcc7 494 60 mrsa mrsa NN cord-287123-ldkuwcc7 494 61 : : : cord-287123-ldkuwcc7 495 1 What what WP cord-287123-ldkuwcc7 495 2 makes make VBZ cord-287123-ldkuwcc7 495 3 them -PRON- PRP cord-287123-ldkuwcc7 495 4 special special JJ cord-287123-ldkuwcc7 495 5 ? ? . cord-287123-ldkuwcc7 496 1 Human Human NNP cord-287123-ldkuwcc7 496 2 formyl formyl NNP cord-287123-ldkuwcc7 496 3 peptide peptide NN cord-287123-ldkuwcc7 496 4 receptor receptor NN cord-287123-ldkuwcc7 496 5 2 2 CD cord-287123-ldkuwcc7 496 6 senses sense NNS cord-287123-ldkuwcc7 496 7 highly highly RB cord-287123-ldkuwcc7 496 8 pathogenic pathogenic JJ cord-287123-ldkuwcc7 496 9 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 496 10 aureus aureus NN cord-287123-ldkuwcc7 496 11 Formyl Formyl NNP cord-287123-ldkuwcc7 496 12 peptide peptide JJ cord-287123-ldkuwcc7 496 13 receptor receptor NN cord-287123-ldkuwcc7 496 14 - - HYPH cord-287123-ldkuwcc7 496 15 mediated mediate VBN cord-287123-ldkuwcc7 496 16 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 496 17 consequences consequence NNS cord-287123-ldkuwcc7 496 18 of of IN cord-287123-ldkuwcc7 496 19 peptide peptide JJ cord-287123-ldkuwcc7 496 20 deformylase deformylase NN cord-287123-ldkuwcc7 496 21 inhibition inhibition NN cord-287123-ldkuwcc7 496 22 in in IN cord-287123-ldkuwcc7 496 23 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 496 24 aureus aureus NN cord-287123-ldkuwcc7 497 1 Receptor receptor NN cord-287123-ldkuwcc7 497 2 - - HYPH cord-287123-ldkuwcc7 497 3 dependent dependent JJ cord-287123-ldkuwcc7 497 4 and and CC cord-287123-ldkuwcc7 497 5 -independent -independent JJ cord-287123-ldkuwcc7 497 6 immunomodulatory immunomodulatory JJ cord-287123-ldkuwcc7 497 7 effects effect NNS cord-287123-ldkuwcc7 497 8 of of IN cord-287123-ldkuwcc7 497 9 phenol phenol NN cord-287123-ldkuwcc7 497 10 - - HYPH cord-287123-ldkuwcc7 497 11 soluble soluble JJ cord-287123-ldkuwcc7 497 12 modulin modulin NN cord-287123-ldkuwcc7 497 13 peptides peptide NNS cord-287123-ldkuwcc7 497 14 from from IN cord-287123-ldkuwcc7 497 15 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 497 16 aureus aureus NN cord-287123-ldkuwcc7 497 17 on on IN cord-287123-ldkuwcc7 497 18 human human JJ cord-287123-ldkuwcc7 497 19 neutrophils neutrophil NNS cord-287123-ldkuwcc7 497 20 are be VBP cord-287123-ldkuwcc7 497 21 abrogated abrogate VBN cord-287123-ldkuwcc7 497 22 through through IN cord-287123-ldkuwcc7 497 23 peptide peptide NN cord-287123-ldkuwcc7 497 24 inactivation inactivation NN cord-287123-ldkuwcc7 497 25 by by IN cord-287123-ldkuwcc7 497 26 reactive reactive JJ cord-287123-ldkuwcc7 497 27 oxygen oxygen NN cord-287123-ldkuwcc7 497 28 species specie NNS cord-287123-ldkuwcc7 497 29 T21 T21 NNP cord-287123-ldkuwcc7 497 30 / / SYM cord-287123-ldkuwcc7 497 31 dp107 dp107 NNP cord-287123-ldkuwcc7 497 32 , , , cord-287123-ldkuwcc7 497 33 a a DT cord-287123-ldkuwcc7 497 34 synthetic synthetic JJ cord-287123-ldkuwcc7 497 35 leucine leucine NN cord-287123-ldkuwcc7 497 36 zipper zipper NN cord-287123-ldkuwcc7 497 37 - - HYPH cord-287123-ldkuwcc7 497 38 like like JJ cord-287123-ldkuwcc7 497 39 domain domain NN cord-287123-ldkuwcc7 497 40 of of IN cord-287123-ldkuwcc7 497 41 the the DT cord-287123-ldkuwcc7 497 42 hiv-1 hiv-1 NNP cord-287123-ldkuwcc7 497 43 envelope envelope NN cord-287123-ldkuwcc7 497 44 gp41 gp41 NNP cord-287123-ldkuwcc7 497 45 , , , cord-287123-ldkuwcc7 497 46 attracts attract VBZ cord-287123-ldkuwcc7 497 47 and and CC cord-287123-ldkuwcc7 497 48 activates activate VBZ cord-287123-ldkuwcc7 497 49 human human JJ cord-287123-ldkuwcc7 497 50 phagocytes phagocyte NNS cord-287123-ldkuwcc7 497 51 by by IN cord-287123-ldkuwcc7 497 52 using use VBG cord-287123-ldkuwcc7 497 53 g g NN cord-287123-ldkuwcc7 497 54 - - HYPH cord-287123-ldkuwcc7 497 55 protein protein NN cord-287123-ldkuwcc7 497 56 - - HYPH cord-287123-ldkuwcc7 497 57 coupled couple VBN cord-287123-ldkuwcc7 497 58 formyl formyl NN cord-287123-ldkuwcc7 497 59 peptide peptide NN cord-287123-ldkuwcc7 497 60 receptors receptor NNS cord-287123-ldkuwcc7 497 61 T20 T20 NNP cord-287123-ldkuwcc7 497 62 / / SYM cord-287123-ldkuwcc7 497 63 dp178 dp178 NNP cord-287123-ldkuwcc7 497 64 , , , cord-287123-ldkuwcc7 497 65 an an DT cord-287123-ldkuwcc7 497 66 ectodomain ectodomain JJ cord-287123-ldkuwcc7 497 67 peptide peptide NN cord-287123-ldkuwcc7 497 68 of of IN cord-287123-ldkuwcc7 497 69 human human JJ cord-287123-ldkuwcc7 497 70 immunodeficiency immunodeficiency NN cord-287123-ldkuwcc7 497 71 virus virus NN cord-287123-ldkuwcc7 497 72 type type NN cord-287123-ldkuwcc7 497 73 1 1 CD cord-287123-ldkuwcc7 497 74 gp41 gp41 NNP cord-287123-ldkuwcc7 497 75 , , , cord-287123-ldkuwcc7 497 76 is be VBZ cord-287123-ldkuwcc7 497 77 an an DT cord-287123-ldkuwcc7 497 78 activator activator NN cord-287123-ldkuwcc7 497 79 of of IN cord-287123-ldkuwcc7 497 80 human human JJ cord-287123-ldkuwcc7 497 81 phagocyte phagocyte NNP cord-287123-ldkuwcc7 497 82 n n NNP cord-287123-ldkuwcc7 497 83 - - HYPH cord-287123-ldkuwcc7 497 84 formyl formyl NNP cord-287123-ldkuwcc7 497 85 peptide peptide NN cord-287123-ldkuwcc7 497 86 receptor receptor NN cord-287123-ldkuwcc7 497 87 A a DT cord-287123-ldkuwcc7 497 88 synthetic synthetic JJ cord-287123-ldkuwcc7 497 89 peptide peptide NN cord-287123-ldkuwcc7 497 90 derived derive VBN cord-287123-ldkuwcc7 497 91 from from IN cord-287123-ldkuwcc7 497 92 human human JJ cord-287123-ldkuwcc7 497 93 immunodeficiency immunodeficiency NN cord-287123-ldkuwcc7 497 94 virus virus NN cord-287123-ldkuwcc7 497 95 type type NN cord-287123-ldkuwcc7 497 96 1 1 CD cord-287123-ldkuwcc7 497 97 gp120 gp120 NNP cord-287123-ldkuwcc7 497 98 downregulates downregulate VBZ cord-287123-ldkuwcc7 497 99 the the DT cord-287123-ldkuwcc7 497 100 expression expression NN cord-287123-ldkuwcc7 497 101 and and CC cord-287123-ldkuwcc7 497 102 function function NN cord-287123-ldkuwcc7 497 103 of of IN cord-287123-ldkuwcc7 497 104 chemokine chemokine NN cord-287123-ldkuwcc7 497 105 receptors receptor NNS cord-287123-ldkuwcc7 497 106 ccr5 ccr5 VBN cord-287123-ldkuwcc7 497 107 and and CC cord-287123-ldkuwcc7 497 108 cxcr4 cxcr4 NN cord-287123-ldkuwcc7 497 109 in in IN cord-287123-ldkuwcc7 497 110 monocytes monocyte NNS cord-287123-ldkuwcc7 497 111 by by IN cord-287123-ldkuwcc7 497 112 activating activate VBG cord-287123-ldkuwcc7 497 113 the the DT cord-287123-ldkuwcc7 497 114 7-transmembrane 7-transmembrane CD cord-287123-ldkuwcc7 497 115 g g NN cord-287123-ldkuwcc7 497 116 - - HYPH cord-287123-ldkuwcc7 497 117 protein protein NN cord-287123-ldkuwcc7 497 118 - - HYPH cord-287123-ldkuwcc7 497 119 coupled couple VBN cord-287123-ldkuwcc7 497 120 receptor receptor NN cord-287123-ldkuwcc7 497 121 fprl1 fprl1 NN cord-287123-ldkuwcc7 497 122 / / SYM cord-287123-ldkuwcc7 497 123 lxa4r lxa4r VBN cord-287123-ldkuwcc7 497 124 N36 N36 NNP cord-287123-ldkuwcc7 497 125 , , , cord-287123-ldkuwcc7 497 126 a a DT cord-287123-ldkuwcc7 497 127 synthetic synthetic JJ cord-287123-ldkuwcc7 497 128 n n JJ cord-287123-ldkuwcc7 497 129 - - HYPH cord-287123-ldkuwcc7 497 130 terminal terminal JJ cord-287123-ldkuwcc7 497 131 heptad heptad NNP cord-287123-ldkuwcc7 497 132 repeat repeat NN cord-287123-ldkuwcc7 497 133 domain domain NN cord-287123-ldkuwcc7 497 134 of of IN cord-287123-ldkuwcc7 497 135 the the DT cord-287123-ldkuwcc7 497 136 hiv-1 hiv-1 NNP cord-287123-ldkuwcc7 497 137 envelope envelope NN cord-287123-ldkuwcc7 497 138 protein protein NN cord-287123-ldkuwcc7 497 139 gp41 gp41 NNP cord-287123-ldkuwcc7 497 140 , , , cord-287123-ldkuwcc7 497 141 is be VBZ cord-287123-ldkuwcc7 497 142 an an DT cord-287123-ldkuwcc7 497 143 activator activator NN cord-287123-ldkuwcc7 497 144 of of IN cord-287123-ldkuwcc7 497 145 human human JJ cord-287123-ldkuwcc7 497 146 phagocytes phagocyte NNS cord-287123-ldkuwcc7 497 147 Activation Activation NNP cord-287123-ldkuwcc7 497 148 of of IN cord-287123-ldkuwcc7 497 149 the the DT cord-287123-ldkuwcc7 497 150 chemotactic chemotactic JJ cord-287123-ldkuwcc7 497 151 peptide peptide NN cord-287123-ldkuwcc7 497 152 receptor receptor NN cord-287123-ldkuwcc7 497 153 fprl1 fprl1 NN cord-287123-ldkuwcc7 497 154 in in IN cord-287123-ldkuwcc7 497 155 monocytes monocyte NNS cord-287123-ldkuwcc7 497 156 phosphorylates phosphorylate VBZ cord-287123-ldkuwcc7 497 157 the the DT cord-287123-ldkuwcc7 497 158 chemokine chemokine NN cord-287123-ldkuwcc7 497 159 receptor receptor NN cord-287123-ldkuwcc7 497 160 ccr5 ccr5 NNP cord-287123-ldkuwcc7 497 161 and and CC cord-287123-ldkuwcc7 497 162 attenuates attenuate VBZ cord-287123-ldkuwcc7 497 163 cell cell NN cord-287123-ldkuwcc7 497 164 responses response NNS cord-287123-ldkuwcc7 497 165 to to IN cord-287123-ldkuwcc7 497 166 selected select VBN cord-287123-ldkuwcc7 497 167 chemokines chemokine NNS cord-287123-ldkuwcc7 497 168 The the DT cord-287123-ldkuwcc7 497 169 hiv-1 hiv-1 NNP cord-287123-ldkuwcc7 497 170 cell cell NN cord-287123-ldkuwcc7 497 171 entry entry NN cord-287123-ldkuwcc7 497 172 inhibitor inhibitor NN cord-287123-ldkuwcc7 497 173 t-20 t-20 NNP cord-287123-ldkuwcc7 497 174 potently potently RB cord-287123-ldkuwcc7 497 175 chemoattracts chemoattract VBZ cord-287123-ldkuwcc7 497 176 neutrophils neutrophil NNS cord-287123-ldkuwcc7 497 177 by by IN cord-287123-ldkuwcc7 497 178 specifically specifically RB cord-287123-ldkuwcc7 497 179 activating activate VBG cord-287123-ldkuwcc7 497 180 the the DT cord-287123-ldkuwcc7 497 181 n n JJ cord-287123-ldkuwcc7 497 182 - - HYPH cord-287123-ldkuwcc7 497 183 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 497 184 receptor receptor NN cord-287123-ldkuwcc7 497 185 Basophils Basophils NNP cord-287123-ldkuwcc7 497 186 infiltrate infiltrate VBP cord-287123-ldkuwcc7 497 187 human human JJ cord-287123-ldkuwcc7 497 188 gastric gastric JJ cord-287123-ldkuwcc7 497 189 mucosa mucosa NN cord-287123-ldkuwcc7 497 190 at at IN cord-287123-ldkuwcc7 497 191 sites site NNS cord-287123-ldkuwcc7 497 192 of of IN cord-287123-ldkuwcc7 497 193 Helicobacter Helicobacter NNP cord-287123-ldkuwcc7 497 194 pylori pylori NN cord-287123-ldkuwcc7 497 195 infection infection NN cord-287123-ldkuwcc7 497 196 , , , cord-287123-ldkuwcc7 497 197 and and CC cord-287123-ldkuwcc7 497 198 exhibit exhibit VB cord-287123-ldkuwcc7 497 199 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 497 200 in in IN cord-287123-ldkuwcc7 497 201 response response NN cord-287123-ldkuwcc7 497 202 to to IN cord-287123-ldkuwcc7 497 203 h. h. NNP cord-287123-ldkuwcc7 497 204 Pylori Pylori NNP cord-287123-ldkuwcc7 497 205 - - HYPH cord-287123-ldkuwcc7 497 206 derived derive VBN cord-287123-ldkuwcc7 497 207 peptide peptide NN cord-287123-ldkuwcc7 497 208 hp(2 hp(2 NN cord-287123-ldkuwcc7 497 209 - - HYPH cord-287123-ldkuwcc7 497 210 20 20 CD cord-287123-ldkuwcc7 497 211 ) ) -RRB- cord-287123-ldkuwcc7 497 212 Promotion Promotion NNP cord-287123-ldkuwcc7 497 213 of of IN cord-287123-ldkuwcc7 497 214 formyl formyl NNP cord-287123-ldkuwcc7 497 215 peptide peptide NN cord-287123-ldkuwcc7 497 216 receptor receptor NN cord-287123-ldkuwcc7 497 217 1-mediated 1-mediated CD cord-287123-ldkuwcc7 497 218 neutrophil neutrophil NN cord-287123-ldkuwcc7 497 219 chemotactic chemotactic JJ cord-287123-ldkuwcc7 497 220 migration migration NN cord-287123-ldkuwcc7 497 221 by by IN cord-287123-ldkuwcc7 497 222 antimicrobial antimicrobial JJ cord-287123-ldkuwcc7 497 223 peptides peptide NNS cord-287123-ldkuwcc7 497 224 isolated isolate VBN cord-287123-ldkuwcc7 497 225 from from IN cord-287123-ldkuwcc7 497 226 the the DT cord-287123-ldkuwcc7 497 227 centipede centipede NNP cord-287123-ldkuwcc7 497 228 scolopendra scolopendra NNP cord-287123-ldkuwcc7 497 229 subspinipes subspinipes NNP cord-287123-ldkuwcc7 498 1 mutilans mutilans NNP cord-287123-ldkuwcc7 499 1 Serum serum NN cord-287123-ldkuwcc7 499 2 amyloid amyloid NN cord-287123-ldkuwcc7 500 1 a a DT cord-287123-ldkuwcc7 500 2 induces induce VBZ cord-287123-ldkuwcc7 500 3 il-8 il-8 NN cord-287123-ldkuwcc7 500 4 secretion secretion NN cord-287123-ldkuwcc7 500 5 through through IN cord-287123-ldkuwcc7 500 6 a a DT cord-287123-ldkuwcc7 500 7 g g NN cord-287123-ldkuwcc7 500 8 protein protein NN cord-287123-ldkuwcc7 500 9 - - HYPH cord-287123-ldkuwcc7 500 10 coupled couple VBN cord-287123-ldkuwcc7 500 11 receptor receptor NN cord-287123-ldkuwcc7 500 12 , , , cord-287123-ldkuwcc7 500 13 fprl1 fprl1 NN cord-287123-ldkuwcc7 500 14 / / SYM cord-287123-ldkuwcc7 500 15 lxa4r lxa4r VBZ cord-287123-ldkuwcc7 500 16 Local local JJ cord-287123-ldkuwcc7 500 17 expression expression NN cord-287123-ldkuwcc7 500 18 of of IN cord-287123-ldkuwcc7 500 19 the the DT cord-287123-ldkuwcc7 500 20 serum serum NN cord-287123-ldkuwcc7 500 21 amyloid amyloid NN cord-287123-ldkuwcc7 501 1 a a LS cord-287123-ldkuwcc7 501 2 and and CC cord-287123-ldkuwcc7 501 3 formyl formyl NNP cord-287123-ldkuwcc7 501 4 peptide peptide NN cord-287123-ldkuwcc7 501 5 receptor receptor NN cord-287123-ldkuwcc7 501 6 - - HYPH cord-287123-ldkuwcc7 501 7 like like JJ cord-287123-ldkuwcc7 501 8 1 1 CD cord-287123-ldkuwcc7 501 9 genes gene NNS cord-287123-ldkuwcc7 501 10 in in IN cord-287123-ldkuwcc7 501 11 synovial synovial JJ cord-287123-ldkuwcc7 501 12 tissue tissue NN cord-287123-ldkuwcc7 501 13 is be VBZ cord-287123-ldkuwcc7 501 14 associated associate VBN cord-287123-ldkuwcc7 501 15 with with IN cord-287123-ldkuwcc7 501 16 matrix matrix NN cord-287123-ldkuwcc7 501 17 metalloproteinase metalloproteinase NN cord-287123-ldkuwcc7 501 18 production production NN cord-287123-ldkuwcc7 501 19 in in IN cord-287123-ldkuwcc7 501 20 patients patient NNS cord-287123-ldkuwcc7 501 21 with with IN cord-287123-ldkuwcc7 501 22 inflammatory inflammatory JJ cord-287123-ldkuwcc7 501 23 arthritis arthritis NN cord-287123-ldkuwcc7 502 1 Opposing oppose VBG cord-287123-ldkuwcc7 502 2 regulation regulation NN cord-287123-ldkuwcc7 502 3 of of IN cord-287123-ldkuwcc7 502 4 interleukin-8 interleukin-8 NN cord-287123-ldkuwcc7 502 5 and and CC cord-287123-ldkuwcc7 502 6 nf nf NN cord-287123-ldkuwcc7 502 7 - - HYPH cord-287123-ldkuwcc7 502 8 kappab kappab JJ cord-287123-ldkuwcc7 502 9 responses response NNS cord-287123-ldkuwcc7 502 10 by by IN cord-287123-ldkuwcc7 502 11 lipoxin lipoxin NNP cord-287123-ldkuwcc7 502 12 a4 a4 NNP cord-287123-ldkuwcc7 502 13 and and CC cord-287123-ldkuwcc7 502 14 serum serum NN cord-287123-ldkuwcc7 502 15 amyloid amyloid NN cord-287123-ldkuwcc7 503 1 a a DT cord-287123-ldkuwcc7 503 2 via via IN cord-287123-ldkuwcc7 503 3 the the DT cord-287123-ldkuwcc7 503 4 common common JJ cord-287123-ldkuwcc7 503 5 lipoxin lipoxin NNP cord-287123-ldkuwcc7 503 6 a a DT cord-287123-ldkuwcc7 503 7 receptor receptor NN cord-287123-ldkuwcc7 503 8 Differential differential JJ cord-287123-ldkuwcc7 503 9 production production NN cord-287123-ldkuwcc7 503 10 of of IN cord-287123-ldkuwcc7 503 11 leukotriene leukotriene NN cord-287123-ldkuwcc7 503 12 b4 b4 NN cord-287123-ldkuwcc7 503 13 or or CC cord-287123-ldkuwcc7 503 14 prostaglandin prostaglandin NN cord-287123-ldkuwcc7 503 15 e2 e2 NN cord-287123-ldkuwcc7 503 16 by by IN cord-287123-ldkuwcc7 503 17 wkymvm wkymvm NNP cord-287123-ldkuwcc7 503 18 or or CC cord-287123-ldkuwcc7 503 19 serum serum NN cord-287123-ldkuwcc7 503 20 amyloid amyloid NN cord-287123-ldkuwcc7 504 1 a a DT cord-287123-ldkuwcc7 504 2 via via IN cord-287123-ldkuwcc7 504 3 formyl formyl NNP cord-287123-ldkuwcc7 504 4 peptide peptide NN cord-287123-ldkuwcc7 504 5 receptor receptor NN cord-287123-ldkuwcc7 504 6 - - HYPH cord-287123-ldkuwcc7 504 7 like like JJ cord-287123-ldkuwcc7 504 8 1 1 CD cord-287123-ldkuwcc7 504 9 Serum serum NN cord-287123-ldkuwcc7 504 10 amyloid amyloid NN cord-287123-ldkuwcc7 505 1 a a DT cord-287123-ldkuwcc7 505 2 opposes oppose VBZ cord-287123-ldkuwcc7 505 3 lipoxin lipoxin NNP cord-287123-ldkuwcc7 505 4 a(4 a(4 NNP cord-287123-ldkuwcc7 505 5 ) ) -RRB- cord-287123-ldkuwcc7 505 6 to to TO cord-287123-ldkuwcc7 505 7 mediate mediate VB cord-287123-ldkuwcc7 505 8 glucocorticoid glucocorticoid JJ cord-287123-ldkuwcc7 505 9 refractory refractory JJ cord-287123-ldkuwcc7 505 10 lung lung NN cord-287123-ldkuwcc7 505 11 inflammation inflammation NN cord-287123-ldkuwcc7 505 12 in in IN cord-287123-ldkuwcc7 505 13 chronic chronic JJ cord-287123-ldkuwcc7 505 14 obstructive obstructive JJ cord-287123-ldkuwcc7 505 15 pulmonary pulmonary JJ cord-287123-ldkuwcc7 505 16 disease disease NN cord-287123-ldkuwcc7 505 17 Serum Serum NNP cord-287123-ldkuwcc7 505 18 amyloid amyloid NN cord-287123-ldkuwcc7 506 1 a a DT cord-287123-ldkuwcc7 506 2 mediates mediate VBZ cord-287123-ldkuwcc7 506 3 human human JJ cord-287123-ldkuwcc7 506 4 neutrophil neutrophil NN cord-287123-ldkuwcc7 506 5 production production NN cord-287123-ldkuwcc7 506 6 of of IN cord-287123-ldkuwcc7 506 7 reactive reactive JJ cord-287123-ldkuwcc7 506 8 oxygen oxygen NN cord-287123-ldkuwcc7 506 9 species specie NNS cord-287123-ldkuwcc7 506 10 through through IN cord-287123-ldkuwcc7 506 11 a a DT cord-287123-ldkuwcc7 506 12 receptor receptor NN cord-287123-ldkuwcc7 506 13 independent independent NN cord-287123-ldkuwcc7 506 14 of of IN cord-287123-ldkuwcc7 506 15 formyl formyl NNP cord-287123-ldkuwcc7 506 16 peptide peptide NN cord-287123-ldkuwcc7 506 17 receptor receptor NN cord-287123-ldkuwcc7 506 18 like-1 like-1 NNP cord-287123-ldkuwcc7 506 19 Endogenous Endogenous NNP cord-287123-ldkuwcc7 507 1 acute acute JJ cord-287123-ldkuwcc7 507 2 phase phase NN cord-287123-ldkuwcc7 507 3 serum serum NN cord-287123-ldkuwcc7 507 4 amyloid amyloid NN cord-287123-ldkuwcc7 508 1 a a DT cord-287123-ldkuwcc7 508 2 lacks lack VBZ cord-287123-ldkuwcc7 508 3 pro pro JJ cord-287123-ldkuwcc7 508 4 - - JJ cord-287123-ldkuwcc7 508 5 inflammatory inflammatory JJ cord-287123-ldkuwcc7 508 6 activity activity NN cord-287123-ldkuwcc7 508 7 , , , cord-287123-ldkuwcc7 508 8 contrasting contrast VBG cord-287123-ldkuwcc7 508 9 the the DT cord-287123-ldkuwcc7 508 10 two two CD cord-287123-ldkuwcc7 508 11 recombinant recombinant JJ cord-287123-ldkuwcc7 508 12 variants variant NNS cord-287123-ldkuwcc7 508 13 that that WDT cord-287123-ldkuwcc7 508 14 activate activate VBP cord-287123-ldkuwcc7 508 15 human human JJ cord-287123-ldkuwcc7 508 16 neutrophils neutrophil NNS cord-287123-ldkuwcc7 508 17 through through IN cord-287123-ldkuwcc7 508 18 different different JJ cord-287123-ldkuwcc7 508 19 receptors receptor NNS cord-287123-ldkuwcc7 509 1 Serum serum NN cord-287123-ldkuwcc7 509 2 amyloid amyloid NN cord-287123-ldkuwcc7 509 3 a1 a1 NN cord-287123-ldkuwcc7 509 4 isoforms isoform NNS cord-287123-ldkuwcc7 509 5 display display VBP cord-287123-ldkuwcc7 509 6 different different JJ cord-287123-ldkuwcc7 509 7 efficacy efficacy NN cord-287123-ldkuwcc7 509 8 at at IN cord-287123-ldkuwcc7 509 9 toll toll NN cord-287123-ldkuwcc7 509 10 - - HYPH cord-287123-ldkuwcc7 509 11 like like JJ cord-287123-ldkuwcc7 509 12 receptor receptor NN cord-287123-ldkuwcc7 509 13 2 2 CD cord-287123-ldkuwcc7 509 14 and and CC cord-287123-ldkuwcc7 509 15 formyl formyl NNP cord-287123-ldkuwcc7 509 16 peptide peptide NN cord-287123-ldkuwcc7 509 17 receptor receptor NN cord-287123-ldkuwcc7 510 1 2 2 LS cord-287123-ldkuwcc7 511 1 An an DT cord-287123-ldkuwcc7 511 2 il-23r il-23r NNP cord-287123-ldkuwcc7 511 3 / / SYM cord-287123-ldkuwcc7 511 4 il-22 il-22 NNP cord-287123-ldkuwcc7 511 5 circuit circuit NN cord-287123-ldkuwcc7 511 6 regulates regulate VBZ cord-287123-ldkuwcc7 511 7 epithelial epithelial JJ cord-287123-ldkuwcc7 511 8 serum serum NN cord-287123-ldkuwcc7 511 9 amyloid amyloid NN cord-287123-ldkuwcc7 511 10 a a DT cord-287123-ldkuwcc7 511 11 to to TO cord-287123-ldkuwcc7 511 12 promote promote VB cord-287123-ldkuwcc7 511 13 local local JJ cord-287123-ldkuwcc7 511 14 effector effector NN cord-287123-ldkuwcc7 511 15 th17 th17 NNP cord-287123-ldkuwcc7 511 16 responses response NNS cord-287123-ldkuwcc7 511 17 Th17 Th17 NNP cord-287123-ldkuwcc7 512 1 cell cell NN cord-287123-ldkuwcc7 512 2 induction induction NN cord-287123-ldkuwcc7 512 3 by by IN cord-287123-ldkuwcc7 512 4 adhesion adhesion NN cord-287123-ldkuwcc7 512 5 of of IN cord-287123-ldkuwcc7 512 6 microbes microbe NNS cord-287123-ldkuwcc7 512 7 to to TO cord-287123-ldkuwcc7 512 8 intestinal intestinal VB cord-287123-ldkuwcc7 512 9 epithelial epithelial JJ cord-287123-ldkuwcc7 512 10 cells cell NNS cord-287123-ldkuwcc7 513 1 Pleiotropic Pleiotropic NNP cord-287123-ldkuwcc7 513 2 roles role NNS cord-287123-ldkuwcc7 513 3 of of IN cord-287123-ldkuwcc7 513 4 formyl formyl NNP cord-287123-ldkuwcc7 513 5 peptide peptide NN cord-287123-ldkuwcc7 513 6 receptors receptor NNS cord-287123-ldkuwcc7 513 7 Beta Beta NNP cord-287123-ldkuwcc7 513 8 amyloid amyloid NN cord-287123-ldkuwcc7 513 9 peptide peptide NN cord-287123-ldkuwcc7 513 10 ( ( -LRB- cord-287123-ldkuwcc7 513 11 abeta42 abeta42 NN cord-287123-ldkuwcc7 513 12 ) ) -RRB- cord-287123-ldkuwcc7 513 13 is be VBZ cord-287123-ldkuwcc7 513 14 internalized internalize VBN cord-287123-ldkuwcc7 513 15 via via IN cord-287123-ldkuwcc7 513 16 the the DT cord-287123-ldkuwcc7 513 17 g g NN cord-287123-ldkuwcc7 513 18 - - HYPH cord-287123-ldkuwcc7 513 19 protein protein NN cord-287123-ldkuwcc7 513 20 - - HYPH cord-287123-ldkuwcc7 513 21 coupled couple VBN cord-287123-ldkuwcc7 513 22 receptor receptor NN cord-287123-ldkuwcc7 513 23 fprl1 fprl1 NN cord-287123-ldkuwcc7 513 24 and and CC cord-287123-ldkuwcc7 513 25 forms form VBZ cord-287123-ldkuwcc7 513 26 fibrillar fibrillar NNP cord-287123-ldkuwcc7 513 27 aggregates aggregate NNS cord-287123-ldkuwcc7 513 28 in in IN cord-287123-ldkuwcc7 513 29 macrophages macrophage NNS cord-287123-ldkuwcc7 513 30 Humanin Humanin NNP cord-287123-ldkuwcc7 513 31 , , , cord-287123-ldkuwcc7 513 32 a a DT cord-287123-ldkuwcc7 513 33 newly newly RB cord-287123-ldkuwcc7 513 34 identified identify VBN cord-287123-ldkuwcc7 513 35 neuroprotective neuroprotective JJ cord-287123-ldkuwcc7 513 36 factor factor NN cord-287123-ldkuwcc7 513 37 , , , cord-287123-ldkuwcc7 513 38 uses use VBZ cord-287123-ldkuwcc7 513 39 the the DT cord-287123-ldkuwcc7 513 40 g g NNP cord-287123-ldkuwcc7 513 41 protein protein NN cord-287123-ldkuwcc7 513 42 - - HYPH cord-287123-ldkuwcc7 513 43 coupled couple VBN cord-287123-ldkuwcc7 513 44 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 513 45 receptor receptor NN cord-287123-ldkuwcc7 513 46 - - : cord-287123-ldkuwcc7 513 47 like-1 like-1 NNP cord-287123-ldkuwcc7 513 48 as as IN cord-287123-ldkuwcc7 513 49 a a DT cord-287123-ldkuwcc7 513 50 functional functional JJ cord-287123-ldkuwcc7 513 51 receptor receptor NN cord-287123-ldkuwcc7 513 52 N N NNP cord-287123-ldkuwcc7 513 53 - - HYPH cord-287123-ldkuwcc7 513 54 formylated formylate VBN cord-287123-ldkuwcc7 513 55 humanin humanin NNP cord-287123-ldkuwcc7 513 56 activates activate VBZ cord-287123-ldkuwcc7 513 57 both both DT cord-287123-ldkuwcc7 513 58 formyl formyl NNP cord-287123-ldkuwcc7 513 59 peptide peptide NN cord-287123-ldkuwcc7 513 60 receptor receptor NN cord-287123-ldkuwcc7 513 61 - - HYPH cord-287123-ldkuwcc7 513 62 like like JJ cord-287123-ldkuwcc7 513 63 1 1 CD cord-287123-ldkuwcc7 513 64 and and CC cord-287123-ldkuwcc7 513 65 2 2 CD cord-287123-ldkuwcc7 514 1 An an DT cord-287123-ldkuwcc7 514 2 annexin annexin JJ cord-287123-ldkuwcc7 514 3 1 1 CD cord-287123-ldkuwcc7 514 4 n n JJ cord-287123-ldkuwcc7 514 5 - - HYPH cord-287123-ldkuwcc7 514 6 terminal terminal NN cord-287123-ldkuwcc7 514 7 peptide peptide NN cord-287123-ldkuwcc7 514 8 activates activate VBZ cord-287123-ldkuwcc7 514 9 leukocytes leukocyte NNS cord-287123-ldkuwcc7 514 10 by by IN cord-287123-ldkuwcc7 514 11 triggering trigger VBG cord-287123-ldkuwcc7 514 12 different different JJ cord-287123-ldkuwcc7 514 13 members member NNS cord-287123-ldkuwcc7 514 14 of of IN cord-287123-ldkuwcc7 514 15 the the DT cord-287123-ldkuwcc7 514 16 formyl formyl NNP cord-287123-ldkuwcc7 514 17 peptide peptide NN cord-287123-ldkuwcc7 514 18 receptor receptor NN cord-287123-ldkuwcc7 514 19 family family NN cord-287123-ldkuwcc7 514 20 Neutrophil Neutrophil NNP cord-287123-ldkuwcc7 514 21 nadph nadph NN cord-287123-ldkuwcc7 514 22 - - HYPH cord-287123-ldkuwcc7 514 23 oxidase oxidase NN cord-287123-ldkuwcc7 514 24 activation activation NN cord-287123-ldkuwcc7 514 25 by by IN cord-287123-ldkuwcc7 514 26 an an DT cord-287123-ldkuwcc7 514 27 annexin annexin NN cord-287123-ldkuwcc7 514 28 ai ai NNP cord-287123-ldkuwcc7 514 29 peptide peptide NN cord-287123-ldkuwcc7 514 30 is be VBZ cord-287123-ldkuwcc7 514 31 transduced transduce VBN cord-287123-ldkuwcc7 514 32 by by IN cord-287123-ldkuwcc7 514 33 the the DT cord-287123-ldkuwcc7 514 34 formyl formyl NNP cord-287123-ldkuwcc7 514 35 peptide peptide NN cord-287123-ldkuwcc7 514 36 receptor receptor NN cord-287123-ldkuwcc7 514 37 ( ( -LRB- cord-287123-ldkuwcc7 514 38 fpr fpr NNP cord-287123-ldkuwcc7 514 39 ) ) -RRB- cord-287123-ldkuwcc7 514 40 , , , cord-287123-ldkuwcc7 514 41 whereas whereas IN cord-287123-ldkuwcc7 514 42 an an DT cord-287123-ldkuwcc7 514 43 inhibitory inhibitory JJ cord-287123-ldkuwcc7 514 44 signal signal NN cord-287123-ldkuwcc7 514 45 is be VBZ cord-287123-ldkuwcc7 514 46 generated generate VBN cord-287123-ldkuwcc7 514 47 independently independently RB cord-287123-ldkuwcc7 514 48 of of IN cord-287123-ldkuwcc7 514 49 the the DT cord-287123-ldkuwcc7 514 50 fpr fpr NNP cord-287123-ldkuwcc7 514 51 family family NN cord-287123-ldkuwcc7 514 52 receptors receptor NNS cord-287123-ldkuwcc7 514 53 Mouse Mouse NNP cord-287123-ldkuwcc7 514 54 cathelin cathelin NN cord-287123-ldkuwcc7 514 55 - - HYPH cord-287123-ldkuwcc7 514 56 related relate VBN cord-287123-ldkuwcc7 514 57 antimicrobial antimicrobial JJ cord-287123-ldkuwcc7 514 58 peptide peptide NN cord-287123-ldkuwcc7 514 59 chemoattracts chemoattract NNS cord-287123-ldkuwcc7 514 60 leukocytes leukocyte NNS cord-287123-ldkuwcc7 514 61 using use VBG cord-287123-ldkuwcc7 514 62 formyl formyl NNP cord-287123-ldkuwcc7 514 63 peptide peptide JJ cord-287123-ldkuwcc7 514 64 receptor receptor NN cord-287123-ldkuwcc7 514 65 - - HYPH cord-287123-ldkuwcc7 514 66 like like JJ cord-287123-ldkuwcc7 514 67 1 1 CD cord-287123-ldkuwcc7 514 68 / / SYM cord-287123-ldkuwcc7 514 69 mouse mouse NN cord-287123-ldkuwcc7 514 70 formyl formyl NNP cord-287123-ldkuwcc7 514 71 peptide peptide NN cord-287123-ldkuwcc7 514 72 receptor receptor NN cord-287123-ldkuwcc7 514 73 - - HYPH cord-287123-ldkuwcc7 514 74 like like JJ cord-287123-ldkuwcc7 514 75 2 2 CD cord-287123-ldkuwcc7 514 76 as as IN cord-287123-ldkuwcc7 514 77 the the DT cord-287123-ldkuwcc7 514 78 receptor receptor NN cord-287123-ldkuwcc7 514 79 and and CC cord-287123-ldkuwcc7 514 80 acts act VBZ cord-287123-ldkuwcc7 514 81 as as IN cord-287123-ldkuwcc7 514 82 an an DT cord-287123-ldkuwcc7 514 83 immune immune JJ cord-287123-ldkuwcc7 514 84 adjuvant adjuvant NN cord-287123-ldkuwcc7 514 85 Fprl1-mediated fprl1-mediate VBN cord-287123-ldkuwcc7 514 86 induction induction NN cord-287123-ldkuwcc7 514 87 of of IN cord-287123-ldkuwcc7 514 88 superoxide superoxide NN cord-287123-ldkuwcc7 514 89 in in IN cord-287123-ldkuwcc7 514 90 ll-37-stimulated ll-37-stimulated NNP cord-287123-ldkuwcc7 514 91 imr90 imr90 '' cord-287123-ldkuwcc7 515 1 human human JJ cord-287123-ldkuwcc7 515 2 fibroblast fibroblast NN cord-287123-ldkuwcc7 515 3 Ll-37 Ll-37 NNP cord-287123-ldkuwcc7 515 4 inhibits inhibit VBZ cord-287123-ldkuwcc7 516 1 serum serum NNP cord-287123-ldkuwcc7 516 2 amyloid amyloid NNP cord-287123-ldkuwcc7 516 3 a a DT cord-287123-ldkuwcc7 516 4 - - HYPH cord-287123-ldkuwcc7 516 5 induced induce VBN cord-287123-ldkuwcc7 516 6 il-8 il-8 NN cord-287123-ldkuwcc7 516 7 production production NN cord-287123-ldkuwcc7 516 8 in in IN cord-287123-ldkuwcc7 516 9 human human JJ cord-287123-ldkuwcc7 516 10 neutrophils neutrophil NNS cord-287123-ldkuwcc7 516 11 Human Human NNP cord-287123-ldkuwcc7 516 12 endogenous endogenous JJ cord-287123-ldkuwcc7 516 13 antibiotic antibiotic JJ cord-287123-ldkuwcc7 516 14 ll-37 ll-37 NNP cord-287123-ldkuwcc7 516 15 stimulates stimulate VBZ cord-287123-ldkuwcc7 516 16 airway airway NN cord-287123-ldkuwcc7 516 17 epithelial epithelial JJ cord-287123-ldkuwcc7 516 18 cell cell NN cord-287123-ldkuwcc7 516 19 proliferation proliferation NN cord-287123-ldkuwcc7 516 20 and and CC cord-287123-ldkuwcc7 516 21 wound wound NN cord-287123-ldkuwcc7 516 22 closure closure NN cord-287123-ldkuwcc7 517 1 The the DT cord-287123-ldkuwcc7 517 2 pro pro JJ cord-287123-ldkuwcc7 517 3 - - JJ cord-287123-ldkuwcc7 517 4 inflammatory inflammatory JJ cord-287123-ldkuwcc7 517 5 peptide peptide NN cord-287123-ldkuwcc7 517 6 ll-37 ll-37 NNP cord-287123-ldkuwcc7 517 7 promotes promote VBZ cord-287123-ldkuwcc7 517 8 ovarian ovarian JJ cord-287123-ldkuwcc7 517 9 tumor tumor NN cord-287123-ldkuwcc7 517 10 progression progression NN cord-287123-ldkuwcc7 517 11 through through IN cord-287123-ldkuwcc7 517 12 recruitment recruitment NN cord-287123-ldkuwcc7 517 13 of of IN cord-287123-ldkuwcc7 517 14 multipotent multipotent JJ cord-287123-ldkuwcc7 517 15 mesenchymal mesenchymal JJ cord-287123-ldkuwcc7 517 16 stromal stromal NN cord-287123-ldkuwcc7 517 17 cells cell NNS cord-287123-ldkuwcc7 518 1 Leucine leucine NN cord-287123-ldkuwcc7 518 2 leucine-37 leucine-37 NN cord-287123-ldkuwcc7 518 3 uses use VBZ cord-287123-ldkuwcc7 518 4 formyl formyl NNP cord-287123-ldkuwcc7 518 5 peptide peptide NN cord-287123-ldkuwcc7 518 6 receptor receptor NN cord-287123-ldkuwcc7 518 7 - - HYPH cord-287123-ldkuwcc7 518 8 like like JJ cord-287123-ldkuwcc7 518 9 1 1 CD cord-287123-ldkuwcc7 518 10 to to TO cord-287123-ldkuwcc7 518 11 activate activate VB cord-287123-ldkuwcc7 518 12 signal signal NN cord-287123-ldkuwcc7 518 13 transduction transduction NN cord-287123-ldkuwcc7 518 14 pathways pathway NNS cord-287123-ldkuwcc7 518 15 , , , cord-287123-ldkuwcc7 518 16 stimulate stimulate VBP cord-287123-ldkuwcc7 518 17 oncogenic oncogenic JJ cord-287123-ldkuwcc7 518 18 gene gene NN cord-287123-ldkuwcc7 518 19 expression expression NN cord-287123-ldkuwcc7 518 20 , , , cord-287123-ldkuwcc7 518 21 and and CC cord-287123-ldkuwcc7 518 22 enhance enhance VB cord-287123-ldkuwcc7 518 23 the the DT cord-287123-ldkuwcc7 518 24 invasiveness invasiveness NN cord-287123-ldkuwcc7 518 25 of of IN cord-287123-ldkuwcc7 518 26 ovarian ovarian JJ cord-287123-ldkuwcc7 518 27 cancer cancer NN cord-287123-ldkuwcc7 518 28 cells cell NNS cord-287123-ldkuwcc7 519 1 The the DT cord-287123-ldkuwcc7 519 2 expression expression NN cord-287123-ldkuwcc7 519 3 of of IN cord-287123-ldkuwcc7 519 4 beta beta NN cord-287123-ldkuwcc7 519 5 - - HYPH cord-287123-ldkuwcc7 519 6 defensin-2 defensin-2 NN cord-287123-ldkuwcc7 519 7 , , , cord-287123-ldkuwcc7 519 8 3 3 CD cord-287123-ldkuwcc7 519 9 and and CC cord-287123-ldkuwcc7 519 10 ll-37 ll-37 NNP cord-287123-ldkuwcc7 519 11 induced induce VBN cord-287123-ldkuwcc7 519 12 by by IN cord-287123-ldkuwcc7 519 13 candida candida NNP cord-287123-ldkuwcc7 519 14 albicans albicans NNPS cord-287123-ldkuwcc7 519 15 phospholipomannan phospholipomannan NNP cord-287123-ldkuwcc7 519 16 in in IN cord-287123-ldkuwcc7 519 17 human human JJ cord-287123-ldkuwcc7 519 18 keratinocytes keratinocyte NNS cord-287123-ldkuwcc7 520 1 Leukotriene Leukotriene NNP cord-287123-ldkuwcc7 520 2 b4 b4 NNP cord-287123-ldkuwcc7 520 3 / / SYM cord-287123-ldkuwcc7 520 4 antimicrobial antimicrobial JJ cord-287123-ldkuwcc7 520 5 peptide peptide NN cord-287123-ldkuwcc7 520 6 ll-37 ll-37 NNP cord-287123-ldkuwcc7 520 7 proinflammatory proinflammatory JJ cord-287123-ldkuwcc7 520 8 circuits circuit NNS cord-287123-ldkuwcc7 520 9 are be VBP cord-287123-ldkuwcc7 520 10 mediated mediate VBN cord-287123-ldkuwcc7 520 11 by by IN cord-287123-ldkuwcc7 520 12 blt1 blt1 NN cord-287123-ldkuwcc7 520 13 and and CC cord-287123-ldkuwcc7 520 14 fpr2 fpr2 NNP cord-287123-ldkuwcc7 520 15 / / SYM cord-287123-ldkuwcc7 520 16 alx alx NNP cord-287123-ldkuwcc7 520 17 and and CC cord-287123-ldkuwcc7 520 18 are be VBP cord-287123-ldkuwcc7 520 19 counterregulated counterregulate VBN cord-287123-ldkuwcc7 520 20 by by IN cord-287123-ldkuwcc7 520 21 lipoxin lipoxin NNP cord-287123-ldkuwcc7 520 22 a4 a4 NNP cord-287123-ldkuwcc7 520 23 and and CC cord-287123-ldkuwcc7 520 24 resolvin resolvin NNP cord-287123-ldkuwcc7 520 25 e1 e1 NNP cord-287123-ldkuwcc7 521 1 The the DT cord-287123-ldkuwcc7 521 2 fibrinolytic fibrinolytic JJ cord-287123-ldkuwcc7 521 3 receptor receptor NN cord-287123-ldkuwcc7 521 4 for for IN cord-287123-ldkuwcc7 521 5 urokinase urokinase NN cord-287123-ldkuwcc7 521 6 activates activate VBZ cord-287123-ldkuwcc7 521 7 the the DT cord-287123-ldkuwcc7 521 8 g g NNP cord-287123-ldkuwcc7 521 9 protein protein NN cord-287123-ldkuwcc7 521 10 - - HYPH cord-287123-ldkuwcc7 521 11 coupled couple VBN cord-287123-ldkuwcc7 521 12 chemotactic chemotactic JJ cord-287123-ldkuwcc7 521 13 receptor receptor NN cord-287123-ldkuwcc7 521 14 fprl1 fprl1 NN cord-287123-ldkuwcc7 521 15 / / SYM cord-287123-ldkuwcc7 521 16 lxa4r lxa4r NNP cord-287123-ldkuwcc7 521 17 Identification identification NN cord-287123-ldkuwcc7 521 18 of of IN cord-287123-ldkuwcc7 521 19 fam3d fam3d NN cord-287123-ldkuwcc7 521 20 as as IN cord-287123-ldkuwcc7 521 21 a a DT cord-287123-ldkuwcc7 521 22 new new JJ cord-287123-ldkuwcc7 521 23 endogenous endogenous JJ cord-287123-ldkuwcc7 521 24 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 521 25 agonist agonist NN cord-287123-ldkuwcc7 521 26 for for IN cord-287123-ldkuwcc7 521 27 the the DT cord-287123-ldkuwcc7 521 28 formyl formyl NNP cord-287123-ldkuwcc7 521 29 peptide peptide NN cord-287123-ldkuwcc7 521 30 receptors receptor NNS cord-287123-ldkuwcc7 521 31 Distinct distinct JJ cord-287123-ldkuwcc7 521 32 signaling signal VBG cord-287123-ldkuwcc7 521 33 cascades cascade NNS cord-287123-ldkuwcc7 521 34 elicited elicit VBN cord-287123-ldkuwcc7 521 35 by by IN cord-287123-ldkuwcc7 521 36 different different JJ cord-287123-ldkuwcc7 521 37 formyl formyl NNP cord-287123-ldkuwcc7 521 38 peptide peptide NN cord-287123-ldkuwcc7 521 39 receptor receptor NN cord-287123-ldkuwcc7 521 40 2 2 CD cord-287123-ldkuwcc7 521 41 ( ( -LRB- cord-287123-ldkuwcc7 521 42 fpr2 fpr2 NN cord-287123-ldkuwcc7 521 43 ) ) -RRB- cord-287123-ldkuwcc7 521 44 agonists agonist NNS cord-287123-ldkuwcc7 522 1 The the DT cord-287123-ldkuwcc7 522 2 synthetic synthetic JJ cord-287123-ldkuwcc7 522 3 peptide peptide NN cord-287123-ldkuwcc7 522 4 trp trp NN cord-287123-ldkuwcc7 522 5 - - HYPH cord-287123-ldkuwcc7 522 6 lys lys NNP cord-287123-ldkuwcc7 522 7 - - HYPH cord-287123-ldkuwcc7 522 8 tyr tyr NNP cord-287123-ldkuwcc7 522 9 - - HYPH cord-287123-ldkuwcc7 522 10 met meet VBN cord-287123-ldkuwcc7 522 11 - - HYPH cord-287123-ldkuwcc7 522 12 val val NN cord-287123-ldkuwcc7 522 13 - - HYPH cord-287123-ldkuwcc7 522 14 d d NNP cord-287123-ldkuwcc7 522 15 - - : cord-287123-ldkuwcc7 522 16 met met NNP cord-287123-ldkuwcc7 522 17 inhibits inhibit VBZ cord-287123-ldkuwcc7 522 18 human human JJ cord-287123-ldkuwcc7 522 19 monocyte monocyte NNP cord-287123-ldkuwcc7 522 20 - - HYPH cord-287123-ldkuwcc7 522 21 derived derive VBN cord-287123-ldkuwcc7 522 22 dendritic dendritic JJ cord-287123-ldkuwcc7 522 23 cell cell NN cord-287123-ldkuwcc7 522 24 maturation maturation NN cord-287123-ldkuwcc7 522 25 via via IN cord-287123-ldkuwcc7 522 26 formyl formyl NNP cord-287123-ldkuwcc7 522 27 peptide peptide NN cord-287123-ldkuwcc7 522 28 receptor receptor NN cord-287123-ldkuwcc7 522 29 and and CC cord-287123-ldkuwcc7 522 30 formyl formyl NNP cord-287123-ldkuwcc7 522 31 peptide peptide NN cord-287123-ldkuwcc7 522 32 receptor receptor NN cord-287123-ldkuwcc7 522 33 - - HYPH cord-287123-ldkuwcc7 522 34 like like JJ cord-287123-ldkuwcc7 522 35 2 2 CD cord-287123-ldkuwcc7 522 36 Synthetic synthetic JJ cord-287123-ldkuwcc7 522 37 peptide peptide NN cord-287123-ldkuwcc7 523 1 mmk-1 mmk-1 LS cord-287123-ldkuwcc7 523 2 is be VBZ cord-287123-ldkuwcc7 523 3 a a DT cord-287123-ldkuwcc7 523 4 highly highly RB cord-287123-ldkuwcc7 523 5 specific specific JJ cord-287123-ldkuwcc7 523 6 chemotactic chemotactic JJ cord-287123-ldkuwcc7 523 7 agonist agonist NN cord-287123-ldkuwcc7 523 8 for for IN cord-287123-ldkuwcc7 523 9 leukocyte leukocyte NN cord-287123-ldkuwcc7 524 1 fprl1 fprl1 NNP cord-287123-ldkuwcc7 525 1 A a DT cord-287123-ldkuwcc7 525 2 novel novel JJ cord-287123-ldkuwcc7 525 3 peptide peptide NN cord-287123-ldkuwcc7 525 4 agonist agonist NN cord-287123-ldkuwcc7 525 5 of of IN cord-287123-ldkuwcc7 525 6 formyl formyl NNP cord-287123-ldkuwcc7 525 7 - - HYPH cord-287123-ldkuwcc7 525 8 peptide peptide NN cord-287123-ldkuwcc7 525 9 receptor receptor NN cord-287123-ldkuwcc7 525 10 - - HYPH cord-287123-ldkuwcc7 525 11 like like JJ cord-287123-ldkuwcc7 525 12 1 1 CD cord-287123-ldkuwcc7 525 13 ( ( -LRB- cord-287123-ldkuwcc7 525 14 alx alx NNP cord-287123-ldkuwcc7 525 15 ) ) -RRB- cord-287123-ldkuwcc7 525 16 displays display VBZ cord-287123-ldkuwcc7 525 17 anti anti JJ cord-287123-ldkuwcc7 525 18 - - JJ cord-287123-ldkuwcc7 525 19 inflammatory inflammatory JJ cord-287123-ldkuwcc7 525 20 and and CC cord-287123-ldkuwcc7 525 21 cardioprotective cardioprotective JJ cord-287123-ldkuwcc7 525 22 effects effect NNS cord-287123-ldkuwcc7 526 1 Tethered tethered JJ cord-287123-ldkuwcc7 526 2 ligand ligand NN cord-287123-ldkuwcc7 526 3 library library NN cord-287123-ldkuwcc7 526 4 for for IN cord-287123-ldkuwcc7 526 5 discovery discovery NN cord-287123-ldkuwcc7 526 6 of of IN cord-287123-ldkuwcc7 526 7 peptide peptide NN cord-287123-ldkuwcc7 526 8 agonists agonist NNS cord-287123-ldkuwcc7 526 9 Design Design NNP cord-287123-ldkuwcc7 526 10 , , , cord-287123-ldkuwcc7 526 11 synthesis synthesis NN cord-287123-ldkuwcc7 526 12 and and CC cord-287123-ldkuwcc7 526 13 characterization characterization NN cord-287123-ldkuwcc7 526 14 of of IN cord-287123-ldkuwcc7 526 15 fmlf fmlf NN cord-287123-ldkuwcc7 526 16 - - HYPH cord-287123-ldkuwcc7 526 17 mimicking mimic VBG cord-287123-ldkuwcc7 526 18 aapeptides aapeptide NNS cord-287123-ldkuwcc7 526 19 Characterization characterization NN cord-287123-ldkuwcc7 526 20 of of IN cord-287123-ldkuwcc7 526 21 quin quin NNP cord-287123-ldkuwcc7 526 22 - - HYPH cord-287123-ldkuwcc7 526 23 c1 c1 NNP cord-287123-ldkuwcc7 526 24 for for IN cord-287123-ldkuwcc7 526 25 its -PRON- PRP$ cord-287123-ldkuwcc7 526 26 anti anti JJ cord-287123-ldkuwcc7 526 27 - - JJ cord-287123-ldkuwcc7 526 28 inflammatory inflammatory JJ cord-287123-ldkuwcc7 526 29 property property NN cord-287123-ldkuwcc7 526 30 in in IN cord-287123-ldkuwcc7 526 31 a a DT cord-287123-ldkuwcc7 526 32 mouse mouse NN cord-287123-ldkuwcc7 526 33 model model NN cord-287123-ldkuwcc7 526 34 of of IN cord-287123-ldkuwcc7 526 35 bleomycin bleomycin NN cord-287123-ldkuwcc7 526 36 - - HYPH cord-287123-ldkuwcc7 526 37 induced induce VBN cord-287123-ldkuwcc7 526 38 lung lung NN cord-287123-ldkuwcc7 526 39 injury injury NN cord-287123-ldkuwcc7 526 40 Stable Stable NNP cord-287123-ldkuwcc7 526 41 formyl formyl NNP cord-287123-ldkuwcc7 526 42 peptide peptide NN cord-287123-ldkuwcc7 526 43 receptor receptor NN cord-287123-ldkuwcc7 526 44 agonists agonist NNS cord-287123-ldkuwcc7 526 45 that that WDT cord-287123-ldkuwcc7 526 46 activate activate VBP cord-287123-ldkuwcc7 526 47 the the DT cord-287123-ldkuwcc7 526 48 neutrophil neutrophil NN cord-287123-ldkuwcc7 526 49 nadph nadph NN cord-287123-ldkuwcc7 526 50 - - HYPH cord-287123-ldkuwcc7 526 51 oxidase oxidase NN cord-287123-ldkuwcc7 526 52 identified identify VBN cord-287123-ldkuwcc7 526 53 through through IN cord-287123-ldkuwcc7 526 54 screening screening NN cord-287123-ldkuwcc7 526 55 of of IN cord-287123-ldkuwcc7 526 56 a a DT cord-287123-ldkuwcc7 526 57 compound compound NN cord-287123-ldkuwcc7 526 58 library library NN cord-287123-ldkuwcc7 526 59 A a DT cord-287123-ldkuwcc7 526 60 non non JJ cord-287123-ldkuwcc7 526 61 - - JJ cord-287123-ldkuwcc7 526 62 peptide peptide JJ cord-287123-ldkuwcc7 526 63 receptor receptor NN cord-287123-ldkuwcc7 526 64 inhibitor inhibitor NN cord-287123-ldkuwcc7 526 65 with with IN cord-287123-ldkuwcc7 526 66 selectivity selectivity NN cord-287123-ldkuwcc7 526 67 for for IN cord-287123-ldkuwcc7 526 68 one one CD cord-287123-ldkuwcc7 526 69 of of IN cord-287123-ldkuwcc7 526 70 the the DT cord-287123-ldkuwcc7 526 71 neutrophil neutrophil NN cord-287123-ldkuwcc7 526 72 formyl formyl NNP cord-287123-ldkuwcc7 526 73 peptide peptide NN cord-287123-ldkuwcc7 526 74 receptors receptor NNS cord-287123-ldkuwcc7 526 75 , , , cord-287123-ldkuwcc7 526 76 fpr fpr NN cord-287123-ldkuwcc7 526 77 1 1 CD cord-287123-ldkuwcc7 526 78 Molecular molecular JJ cord-287123-ldkuwcc7 526 79 docking docking NN cord-287123-ldkuwcc7 526 80 of of IN cord-287123-ldkuwcc7 526 81 2-(benzimidazol-2-ylthio)-n 2-(benzimidazol-2-ylthio)-n CD cord-287123-ldkuwcc7 526 82 - - HYPH cord-287123-ldkuwcc7 526 83 phenylacetamide phenylacetamide NN cord-287123-ldkuwcc7 526 84 - - HYPH cord-287123-ldkuwcc7 526 85 derived derive VBN cord-287123-ldkuwcc7 526 86 small small JJ cord-287123-ldkuwcc7 526 87 - - HYPH cord-287123-ldkuwcc7 526 88 molecule molecule NN cord-287123-ldkuwcc7 526 89 agonists agonist NNS cord-287123-ldkuwcc7 526 90 of of IN cord-287123-ldkuwcc7 526 91 human human NNP cord-287123-ldkuwcc7 526 92 formyl formyl NNP cord-287123-ldkuwcc7 526 93 peptide peptide NN cord-287123-ldkuwcc7 526 94 receptor receptor NN cord-287123-ldkuwcc7 526 95 1 1 CD cord-287123-ldkuwcc7 526 96 Further Further NNP cord-287123-ldkuwcc7 526 97 studies study NNS cord-287123-ldkuwcc7 526 98 on on IN cord-287123-ldkuwcc7 526 99 2-arylacetamide 2-arylacetamide CD cord-287123-ldkuwcc7 526 100 pyridazin-3(2H)-ones pyridazin-3(2h)-one NNS cord-287123-ldkuwcc7 526 101 : : : cord-287123-ldkuwcc7 526 102 Design design NN cord-287123-ldkuwcc7 526 103 , , , cord-287123-ldkuwcc7 526 104 synthesis synthesis NN cord-287123-ldkuwcc7 526 105 and and CC cord-287123-ldkuwcc7 526 106 evaluation evaluation NN cord-287123-ldkuwcc7 526 107 of of IN cord-287123-ldkuwcc7 526 108 4,6-disubstituted 4,6-disubstituted JJ cord-287123-ldkuwcc7 526 109 analogs analog NNS cord-287123-ldkuwcc7 526 110 as as IN cord-287123-ldkuwcc7 526 111 formyl formyl NNP cord-287123-ldkuwcc7 526 112 peptide peptide NN cord-287123-ldkuwcc7 526 113 receptors receptor NNS cord-287123-ldkuwcc7 526 114 ( ( -LRB- cord-287123-ldkuwcc7 527 1 fprs fprs NNP cord-287123-ldkuwcc7 527 2 ) ) -RRB- cord-287123-ldkuwcc7 527 3 agonists agonist NNS cord-287123-ldkuwcc7 527 4 High high JJ cord-287123-ldkuwcc7 527 5 - - HYPH cord-287123-ldkuwcc7 527 6 throughput throughput NN cord-287123-ldkuwcc7 527 7 screening screening NN cord-287123-ldkuwcc7 527 8 for for IN cord-287123-ldkuwcc7 527 9 small small JJ cord-287123-ldkuwcc7 527 10 - - HYPH cord-287123-ldkuwcc7 527 11 molecule molecule NN cord-287123-ldkuwcc7 527 12 activators activator NNS cord-287123-ldkuwcc7 527 13 of of IN cord-287123-ldkuwcc7 527 14 neutrophils neutrophil NNS cord-287123-ldkuwcc7 527 15 : : : cord-287123-ldkuwcc7 528 1 Identification identification NN cord-287123-ldkuwcc7 528 2 of of IN cord-287123-ldkuwcc7 528 3 novel novel JJ cord-287123-ldkuwcc7 528 4 n n NNP cord-287123-ldkuwcc7 528 5 - - HYPH cord-287123-ldkuwcc7 528 6 formyl formyl NNP cord-287123-ldkuwcc7 528 7 peptide peptide NN cord-287123-ldkuwcc7 528 8 receptor receptor NN cord-287123-ldkuwcc7 528 9 agonists agonist NNS cord-287123-ldkuwcc7 528 10 Gastrin Gastrin NNP cord-287123-ldkuwcc7 528 11 - - HYPH cord-287123-ldkuwcc7 528 12 releasing release VBG cord-287123-ldkuwcc7 528 13 peptide peptide NN cord-287123-ldkuwcc7 528 14 / / SYM cord-287123-ldkuwcc7 528 15 neuromedin neuromedin NNS cord-287123-ldkuwcc7 528 16 b b NNP cord-287123-ldkuwcc7 528 17 receptor receptor NN cord-287123-ldkuwcc7 528 18 antagonists antagonist NNS cord-287123-ldkuwcc7 528 19 pd176252 pd176252 VBP cord-287123-ldkuwcc7 528 20 , , , cord-287123-ldkuwcc7 528 21 pd168368 pd168368 NNP cord-287123-ldkuwcc7 528 22 , , , cord-287123-ldkuwcc7 528 23 and and CC cord-287123-ldkuwcc7 528 24 related relate VBN cord-287123-ldkuwcc7 528 25 analogs analog NNS cord-287123-ldkuwcc7 528 26 are be VBP cord-287123-ldkuwcc7 528 27 potent potent JJ cord-287123-ldkuwcc7 528 28 agonists agonist NNS cord-287123-ldkuwcc7 528 29 of of IN cord-287123-ldkuwcc7 528 30 human human JJ cord-287123-ldkuwcc7 528 31 formyl formyl NN cord-287123-ldkuwcc7 528 32 - - HYPH cord-287123-ldkuwcc7 528 33 peptide peptide NN cord-287123-ldkuwcc7 528 34 receptors receptor NNS cord-287123-ldkuwcc7 528 35 Lipoxins Lipoxins NNP cord-287123-ldkuwcc7 528 36 and and CC cord-287123-ldkuwcc7 528 37 aspirin aspirin NN cord-287123-ldkuwcc7 528 38 - - HYPH cord-287123-ldkuwcc7 528 39 triggered trigger VBN cord-287123-ldkuwcc7 528 40 15-epi 15-epi CD cord-287123-ldkuwcc7 528 41 - - HYPH cord-287123-ldkuwcc7 528 42 lipoxins lipoxin NNS cord-287123-ldkuwcc7 528 43 are be VBP cord-287123-ldkuwcc7 528 44 the the DT cord-287123-ldkuwcc7 528 45 first first JJ cord-287123-ldkuwcc7 528 46 lipid lipid NN cord-287123-ldkuwcc7 528 47 mediators mediator NNS cord-287123-ldkuwcc7 528 48 of of IN cord-287123-ldkuwcc7 528 49 endogenous endogenous JJ cord-287123-ldkuwcc7 528 50 anti anti JJ cord-287123-ldkuwcc7 528 51 - - JJ cord-287123-ldkuwcc7 528 52 inflammation inflammation JJ cord-287123-ldkuwcc7 528 53 and and CC cord-287123-ldkuwcc7 528 54 resolution resolution NN cord-287123-ldkuwcc7 529 1 The the DT cord-287123-ldkuwcc7 529 2 lipoxin lipoxin NNP cord-287123-ldkuwcc7 529 3 receptor receptor NN cord-287123-ldkuwcc7 529 4 alx alx NNP cord-287123-ldkuwcc7 529 5 : : : cord-287123-ldkuwcc7 530 1 Potent potent JJ cord-287123-ldkuwcc7 530 2 ligand ligand NN cord-287123-ldkuwcc7 530 3 - - HYPH cord-287123-ldkuwcc7 530 4 specific specific JJ cord-287123-ldkuwcc7 530 5 and and CC cord-287123-ldkuwcc7 530 6 stereoselective stereoselective JJ cord-287123-ldkuwcc7 530 7 actions action NNS cord-287123-ldkuwcc7 530 8 in in IN cord-287123-ldkuwcc7 530 9 vivo vivo NNP cord-287123-ldkuwcc7 530 10 Lipoxins Lipoxins NNP cord-287123-ldkuwcc7 530 11 : : : cord-287123-ldkuwcc7 530 12 Update update NN cord-287123-ldkuwcc7 530 13 and and CC cord-287123-ldkuwcc7 530 14 impact impact NN cord-287123-ldkuwcc7 530 15 of of IN cord-287123-ldkuwcc7 530 16 endogenous endogenous JJ cord-287123-ldkuwcc7 530 17 pro pro JJ cord-287123-ldkuwcc7 530 18 - - JJ cord-287123-ldkuwcc7 530 19 resolution resolution JJ cord-287123-ldkuwcc7 530 20 lipid lipid NN cord-287123-ldkuwcc7 530 21 mediators mediator NNS cord-287123-ldkuwcc7 530 22 Resolution Resolution NNP cord-287123-ldkuwcc7 530 23 of of IN cord-287123-ldkuwcc7 530 24 inflammation inflammation NN cord-287123-ldkuwcc7 530 25 : : : cord-287123-ldkuwcc7 530 26 State state NN cord-287123-ldkuwcc7 530 27 of of IN cord-287123-ldkuwcc7 530 28 the the DT cord-287123-ldkuwcc7 530 29 art art NN cord-287123-ldkuwcc7 530 30 , , , cord-287123-ldkuwcc7 530 31 definitions definition NNS cord-287123-ldkuwcc7 530 32 and and CC cord-287123-ldkuwcc7 530 33 terms term NNS cord-287123-ldkuwcc7 530 34 Identification identification NN cord-287123-ldkuwcc7 530 35 , , , cord-287123-ldkuwcc7 530 36 cloning clone VBG cord-287123-ldkuwcc7 530 37 , , , cord-287123-ldkuwcc7 530 38 and and CC cord-287123-ldkuwcc7 530 39 functional functional JJ cord-287123-ldkuwcc7 530 40 characterization characterization NN cord-287123-ldkuwcc7 530 41 of of IN cord-287123-ldkuwcc7 530 42 a a DT cord-287123-ldkuwcc7 530 43 murine murine JJ cord-287123-ldkuwcc7 530 44 lipoxin lipoxin NNP cord-287123-ldkuwcc7 530 45 a4 a4 NNP cord-287123-ldkuwcc7 530 46 receptor receptor NNP cord-287123-ldkuwcc7 530 47 homologue homologue NN cord-287123-ldkuwcc7 530 48 gene gene NN cord-287123-ldkuwcc7 530 49 Lipoxin Lipoxin NNP cord-287123-ldkuwcc7 530 50 a(4 a(4 NNP cord-287123-ldkuwcc7 530 51 ) ) -RRB- cord-287123-ldkuwcc7 531 1 metabolites metabolite NNS cord-287123-ldkuwcc7 531 2 / / SYM cord-287123-ldkuwcc7 531 3 analogues analogue NNS cord-287123-ldkuwcc7 531 4 from from IN cord-287123-ldkuwcc7 531 5 two two CD cord-287123-ldkuwcc7 531 6 commercial commercial JJ cord-287123-ldkuwcc7 531 7 sources source NNS cord-287123-ldkuwcc7 531 8 have have VBP cord-287123-ldkuwcc7 531 9 no no DT cord-287123-ldkuwcc7 531 10 effects effect NNS cord-287123-ldkuwcc7 531 11 on on IN cord-287123-ldkuwcc7 531 12 tnf tnf NN cord-287123-ldkuwcc7 531 13 - - HYPH cord-287123-ldkuwcc7 531 14 alpha alpha NN cord-287123-ldkuwcc7 531 15 - - HYPH cord-287123-ldkuwcc7 531 16 mediated mediate VBN cord-287123-ldkuwcc7 531 17 priming priming NN cord-287123-ldkuwcc7 531 18 or or CC cord-287123-ldkuwcc7 531 19 activation activation VB cord-287123-ldkuwcc7 531 20 through through IN cord-287123-ldkuwcc7 531 21 the the DT cord-287123-ldkuwcc7 531 22 neutrophil neutrophil NN cord-287123-ldkuwcc7 531 23 formyl formyl NNP cord-287123-ldkuwcc7 531 24 peptide peptide NN cord-287123-ldkuwcc7 531 25 receptors receptor NNS cord-287123-ldkuwcc7 532 1 What what WP cord-287123-ldkuwcc7 532 2 formyl formyl NN cord-287123-ldkuwcc7 532 3 peptide peptide NN cord-287123-ldkuwcc7 532 4 receptors receptor NNS cord-287123-ldkuwcc7 532 5 , , , cord-287123-ldkuwcc7 532 6 if if IN cord-287123-ldkuwcc7 532 7 any any DT cord-287123-ldkuwcc7 532 8 , , , cord-287123-ldkuwcc7 532 9 are be VBP cord-287123-ldkuwcc7 532 10 triggered trigger VBN cord-287123-ldkuwcc7 532 11 by by IN cord-287123-ldkuwcc7 532 12 compound compound NN cord-287123-ldkuwcc7 532 13 43 43 CD cord-287123-ldkuwcc7 532 14 and and CC cord-287123-ldkuwcc7 532 15 lipoxin lipoxin NNP cord-287123-ldkuwcc7 532 16 a4 a4 NNP cord-287123-ldkuwcc7 532 17 ? ? . cord-287123-ldkuwcc7 533 1 Heterologously Heterologously NNP cord-287123-ldkuwcc7 533 2 expressed express VBD cord-287123-ldkuwcc7 533 3 formyl formyl NNP cord-287123-ldkuwcc7 533 4 peptide peptide NN cord-287123-ldkuwcc7 533 5 receptor receptor NN cord-287123-ldkuwcc7 533 6 2 2 CD cord-287123-ldkuwcc7 533 7 ( ( -LRB- cord-287123-ldkuwcc7 533 8 fpr2 fpr2 NNP cord-287123-ldkuwcc7 533 9 / / SYM cord-287123-ldkuwcc7 533 10 alx alx NNP cord-287123-ldkuwcc7 533 11 ) ) -RRB- cord-287123-ldkuwcc7 533 12 does do VBZ cord-287123-ldkuwcc7 533 13 not not RB cord-287123-ldkuwcc7 533 14 respond respond VB cord-287123-ldkuwcc7 533 15 to to TO cord-287123-ldkuwcc7 533 16 lipoxin lipoxin VB cord-287123-ldkuwcc7 533 17 a(4 a(4 NNP cord-287123-ldkuwcc7 533 18 ) ) -RRB- cord-287123-ldkuwcc7 534 1 Anti anti JJ cord-287123-ldkuwcc7 534 2 - - JJ cord-287123-ldkuwcc7 534 3 inflammatory inflammatory JJ cord-287123-ldkuwcc7 534 4 lipoxin lipoxin NNP cord-287123-ldkuwcc7 534 5 a4 a4 NNP cord-287123-ldkuwcc7 534 6 is be VBZ cord-287123-ldkuwcc7 534 7 an an DT cord-287123-ldkuwcc7 534 8 endogenous endogenous JJ cord-287123-ldkuwcc7 534 9 allosteric allosteric JJ cord-287123-ldkuwcc7 534 10 enhancer enhancer NN cord-287123-ldkuwcc7 534 11 of of IN cord-287123-ldkuwcc7 534 12 cb1 cb1 NNP cord-287123-ldkuwcc7 534 13 cannabinoid cannabinoid NN cord-287123-ldkuwcc7 534 14 receptor receptor NN cord-287123-ldkuwcc7 534 15 Lipoxin Lipoxin NNP cord-287123-ldkuwcc7 534 16 a4 a4 NNP cord-287123-ldkuwcc7 534 17 : : : cord-287123-ldkuwcc7 534 18 A a DT cord-287123-ldkuwcc7 534 19 new new JJ cord-287123-ldkuwcc7 534 20 class class NN cord-287123-ldkuwcc7 534 21 of of IN cord-287123-ldkuwcc7 534 22 ligand ligand NN cord-287123-ldkuwcc7 534 23 for for IN cord-287123-ldkuwcc7 534 24 the the DT cord-287123-ldkuwcc7 534 25 ah ah NNP cord-287123-ldkuwcc7 534 26 receptor receptor NN cord-287123-ldkuwcc7 534 27 Lipoxin Lipoxin NNP cord-287123-ldkuwcc7 534 28 a4 a4 NNP cord-287123-ldkuwcc7 534 29 is be VBZ cord-287123-ldkuwcc7 534 30 a a DT cord-287123-ldkuwcc7 534 31 novel novel JJ cord-287123-ldkuwcc7 534 32 estrogen estrogen NN cord-287123-ldkuwcc7 534 33 receptor receptor NN cord-287123-ldkuwcc7 534 34 modulator modulator NN cord-287123-ldkuwcc7 534 35 Resolvin Resolvin NNP cord-287123-ldkuwcc7 534 36 d1 d1 NN cord-287123-ldkuwcc7 534 37 binds bind VBZ cord-287123-ldkuwcc7 534 38 human human JJ cord-287123-ldkuwcc7 534 39 phagocytes phagocyte NNS cord-287123-ldkuwcc7 534 40 with with IN cord-287123-ldkuwcc7 534 41 evidence evidence NN cord-287123-ldkuwcc7 534 42 for for IN cord-287123-ldkuwcc7 534 43 proresolving proresolve VBG cord-287123-ldkuwcc7 534 44 receptors receptor NNS cord-287123-ldkuwcc7 534 45 Resolvin Resolvin NNP cord-287123-ldkuwcc7 534 46 d1 d1 NN cord-287123-ldkuwcc7 534 47 prevents prevent VBZ cord-287123-ldkuwcc7 534 48 tnf tnf NNP cord-287123-ldkuwcc7 534 49 - - HYPH cord-287123-ldkuwcc7 534 50 alphamediated alphamediate VBN cord-287123-ldkuwcc7 534 51 disruption disruption NN cord-287123-ldkuwcc7 534 52 of of IN cord-287123-ldkuwcc7 534 53 salivary salivary JJ cord-287123-ldkuwcc7 534 54 epithelial epithelial JJ cord-287123-ldkuwcc7 534 55 formation formation NN cord-287123-ldkuwcc7 535 1 Aspirin aspirin NN cord-287123-ldkuwcc7 535 2 - - HYPH cord-287123-ldkuwcc7 535 3 triggered trigger VBN cord-287123-ldkuwcc7 535 4 resolvin resolvin NN cord-287123-ldkuwcc7 535 5 d1 d1 NNP cord-287123-ldkuwcc7 535 6 reduces reduce VBZ cord-287123-ldkuwcc7 535 7 mucosal mucosal JJ cord-287123-ldkuwcc7 535 8 inflammation inflammation NN cord-287123-ldkuwcc7 535 9 and and CC cord-287123-ldkuwcc7 535 10 promotes promote VBZ cord-287123-ldkuwcc7 535 11 resolution resolution NN cord-287123-ldkuwcc7 535 12 in in IN cord-287123-ldkuwcc7 535 13 a a DT cord-287123-ldkuwcc7 535 14 murine murine JJ cord-287123-ldkuwcc7 535 15 model model NN cord-287123-ldkuwcc7 535 16 of of IN cord-287123-ldkuwcc7 535 17 acute acute JJ cord-287123-ldkuwcc7 535 18 lung lung NN cord-287123-ldkuwcc7 535 19 injury injury NN cord-287123-ldkuwcc7 536 1 Resolvin Resolvin NNP cord-287123-ldkuwcc7 536 2 d1 d1 NN cord-287123-ldkuwcc7 536 3 and and CC cord-287123-ldkuwcc7 536 4 resolvin resolvin NNP cord-287123-ldkuwcc7 536 5 d2 d2 NNP cord-287123-ldkuwcc7 536 6 govern govern VBP cord-287123-ldkuwcc7 536 7 local local JJ cord-287123-ldkuwcc7 536 8 inflammatory inflammatory JJ cord-287123-ldkuwcc7 536 9 tone tone NN cord-287123-ldkuwcc7 536 10 in in IN cord-287123-ldkuwcc7 536 11 obese obese JJ cord-287123-ldkuwcc7 536 12 fat fat NN cord-287123-ldkuwcc7 536 13 Oxidized oxidize VBN cord-287123-ldkuwcc7 536 14 low low JJ cord-287123-ldkuwcc7 536 15 - - HYPH cord-287123-ldkuwcc7 536 16 density density NN cord-287123-ldkuwcc7 536 17 lipoprotein lipoprotein NN cord-287123-ldkuwcc7 536 18 - - HYPH cord-287123-ldkuwcc7 536 19 induced induce VBN cord-287123-ldkuwcc7 536 20 foam foam NN cord-287123-ldkuwcc7 536 21 cell cell NN cord-287123-ldkuwcc7 536 22 formation formation NN cord-287123-ldkuwcc7 536 23 is be VBZ cord-287123-ldkuwcc7 536 24 mediated mediate VBN cord-287123-ldkuwcc7 536 25 by by IN cord-287123-ldkuwcc7 536 26 formyl formyl NNP cord-287123-ldkuwcc7 536 27 peptide peptide NN cord-287123-ldkuwcc7 536 28 receptor receptor NN cord-287123-ldkuwcc7 536 29 2 2 CD cord-287123-ldkuwcc7 536 30 Insider insider NN cord-287123-ldkuwcc7 536 31 access access NN cord-287123-ldkuwcc7 536 32 : : : cord-287123-ldkuwcc7 536 33 Pepducin Pepducin NNP cord-287123-ldkuwcc7 536 34 symposium symposium NN cord-287123-ldkuwcc7 536 35 explores explore VBZ cord-287123-ldkuwcc7 536 36 a a DT cord-287123-ldkuwcc7 536 37 new new JJ cord-287123-ldkuwcc7 536 38 approach approach NN cord-287123-ldkuwcc7 536 39 to to IN cord-287123-ldkuwcc7 536 40 gpcr gpcr NNP cord-287123-ldkuwcc7 536 41 modulation modulation NN cord-287123-ldkuwcc7 536 42 Turning turn VBG cord-287123-ldkuwcc7 536 43 receptors receptor NNS cord-287123-ldkuwcc7 536 44 on on IN cord-287123-ldkuwcc7 536 45 and and CC cord-287123-ldkuwcc7 536 46 off off RB cord-287123-ldkuwcc7 536 47 with with IN cord-287123-ldkuwcc7 536 48 intracellular intracellular JJ cord-287123-ldkuwcc7 536 49 pepducins pepducin NNS cord-287123-ldkuwcc7 536 50 : : : cord-287123-ldkuwcc7 537 1 New new JJ cord-287123-ldkuwcc7 537 2 insights insight NNS cord-287123-ldkuwcc7 537 3 into into IN cord-287123-ldkuwcc7 537 4 g g NN cord-287123-ldkuwcc7 537 5 - - HYPH cord-287123-ldkuwcc7 537 6 protein protein NN cord-287123-ldkuwcc7 537 7 - - HYPH cord-287123-ldkuwcc7 537 8 coupled couple VBN cord-287123-ldkuwcc7 537 9 receptor receptor NN cord-287123-ldkuwcc7 537 10 drug drug NN cord-287123-ldkuwcc7 537 11 development development NN cord-287123-ldkuwcc7 537 12 A a DT cord-287123-ldkuwcc7 537 13 pepducin pepducin NNS cord-287123-ldkuwcc7 537 14 derived derive VBN cord-287123-ldkuwcc7 537 15 from from IN cord-287123-ldkuwcc7 537 16 the the DT cord-287123-ldkuwcc7 537 17 third third JJ cord-287123-ldkuwcc7 537 18 intracellular intracellular JJ cord-287123-ldkuwcc7 537 19 loop loop NN cord-287123-ldkuwcc7 537 20 of of IN cord-287123-ldkuwcc7 537 21 fpr2 fpr2 NN cord-287123-ldkuwcc7 537 22 is be VBZ cord-287123-ldkuwcc7 537 23 a a DT cord-287123-ldkuwcc7 537 24 partial partial JJ cord-287123-ldkuwcc7 537 25 agonist agonist NN cord-287123-ldkuwcc7 537 26 for for IN cord-287123-ldkuwcc7 537 27 direct direct JJ cord-287123-ldkuwcc7 537 28 activation activation NN cord-287123-ldkuwcc7 537 29 of of IN cord-287123-ldkuwcc7 537 30 this this DT cord-287123-ldkuwcc7 537 31 receptor receptor NN cord-287123-ldkuwcc7 537 32 in in IN cord-287123-ldkuwcc7 537 33 neutrophils neutrophil NNS cord-287123-ldkuwcc7 537 34 but but CC cord-287123-ldkuwcc7 537 35 a a DT cord-287123-ldkuwcc7 537 36 full full JJ cord-287123-ldkuwcc7 537 37 agonist agonist NN cord-287123-ldkuwcc7 537 38 for for IN cord-287123-ldkuwcc7 537 39 cross cross JJ cord-287123-ldkuwcc7 537 40 - - NN cord-287123-ldkuwcc7 537 41 talk talk NN cord-287123-ldkuwcc7 537 42 triggered trigger VBN cord-287123-ldkuwcc7 537 43 reactivation reactivation NN cord-287123-ldkuwcc7 537 44 of of IN cord-287123-ldkuwcc7 537 45 fpr2 fpr2 NNP cord-287123-ldkuwcc7 537 46 A a DT cord-287123-ldkuwcc7 537 47 pepducin pepducin NNS cord-287123-ldkuwcc7 537 48 designed design VBN cord-287123-ldkuwcc7 537 49 to to TO cord-287123-ldkuwcc7 537 50 modulate modulate VB cord-287123-ldkuwcc7 537 51 p2y2r p2y2r CD cord-287123-ldkuwcc7 537 52 function function NN cord-287123-ldkuwcc7 537 53 interacts interact VBZ cord-287123-ldkuwcc7 537 54 with with IN cord-287123-ldkuwcc7 537 55 fpr2 fpr2 NNS cord-287123-ldkuwcc7 537 56 in in IN cord-287123-ldkuwcc7 537 57 human human JJ cord-287123-ldkuwcc7 537 58 neutrophils neutrophil NNS cord-287123-ldkuwcc7 537 59 and and CC cord-287123-ldkuwcc7 537 60 transfers transfer VBZ cord-287123-ldkuwcc7 537 61 atp atp NNP cord-287123-ldkuwcc7 537 62 to to IN cord-287123-ldkuwcc7 537 63 an an DT cord-287123-ldkuwcc7 537 64 nadph nadph NN cord-287123-ldkuwcc7 537 65 - - HYPH cord-287123-ldkuwcc7 537 66 oxidase oxidase NN cord-287123-ldkuwcc7 537 67 - - HYPH cord-287123-ldkuwcc7 537 68 activating activate VBG cord-287123-ldkuwcc7 537 69 ligand ligand NN cord-287123-ldkuwcc7 537 70 through through IN cord-287123-ldkuwcc7 537 71 a a DT cord-287123-ldkuwcc7 537 72 receptor receptor NN cord-287123-ldkuwcc7 537 73 cross cross JJ cord-287123-ldkuwcc7 537 74 - - JJ cord-287123-ldkuwcc7 537 75 talk talk JJ cord-287123-ldkuwcc7 537 76 mechanism mechanism NN cord-287123-ldkuwcc7 537 77 Data datum NNS cord-287123-ldkuwcc7 537 78 on on IN cord-287123-ldkuwcc7 537 79 human human JJ cord-287123-ldkuwcc7 537 80 neutrophil neutrophil NN cord-287123-ldkuwcc7 537 81 activation activation NN cord-287123-ldkuwcc7 537 82 induced induce VBN cord-287123-ldkuwcc7 537 83 by by IN cord-287123-ldkuwcc7 537 84 pepducins pepducin NNS cord-287123-ldkuwcc7 537 85 with with IN cord-287123-ldkuwcc7 537 86 amino amino NN cord-287123-ldkuwcc7 537 87 acid acid NN cord-287123-ldkuwcc7 537 88 sequences sequence NNS cord-287123-ldkuwcc7 537 89 derived derive VBN cord-287123-ldkuwcc7 537 90 from from IN cord-287123-ldkuwcc7 537 91 β2ar β2ar NN cord-287123-ldkuwcc7 537 92 and and CC cord-287123-ldkuwcc7 537 93 cxcr4 cxcr4 NN cord-287123-ldkuwcc7 537 94 . . . cord-287123-ldkuwcc7 538 1 Data datum NNS cord-287123-ldkuwcc7 538 2 Brief Brief NNP cord-287123-ldkuwcc7 538 3 Localization Localization NNP cord-287123-ldkuwcc7 538 4 of of IN cord-287123-ldkuwcc7 538 5 radiolabeled radiolabeled JJ cord-287123-ldkuwcc7 538 6 chemotactic chemotactic JJ cord-287123-ldkuwcc7 538 7 peptide peptide NN cord-287123-ldkuwcc7 538 8 at at IN cord-287123-ldkuwcc7 538 9 focal focal JJ cord-287123-ldkuwcc7 538 10 sites site NNS cord-287123-ldkuwcc7 538 11 of of IN cord-287123-ldkuwcc7 538 12 escherichia escherichia NNP cord-287123-ldkuwcc7 538 13 coli coli VBZ cord-287123-ldkuwcc7 538 14 infection infection NN cord-287123-ldkuwcc7 538 15 in in IN cord-287123-ldkuwcc7 538 16 rabbits rabbit NNS cord-287123-ldkuwcc7 538 17 : : : cord-287123-ldkuwcc7 538 18 Evidence evidence NN cord-287123-ldkuwcc7 538 19 for for IN cord-287123-ldkuwcc7 538 20 a a DT cord-287123-ldkuwcc7 538 21 receptor receptor NN cord-287123-ldkuwcc7 538 22 - - HYPH cord-287123-ldkuwcc7 538 23 specific specific JJ cord-287123-ldkuwcc7 538 24 mechanism mechanism NN cord-287123-ldkuwcc7 538 25 A a DT cord-287123-ldkuwcc7 538 26 novel novel JJ cord-287123-ldkuwcc7 538 27 neutrophil neutrophil NN cord-287123-ldkuwcc7 538 28 - - HYPH cord-287123-ldkuwcc7 538 29 specific specific JJ cord-287123-ldkuwcc7 538 30 pet pet JJ cord-287123-ldkuwcc7 538 31 imaging imaging NN cord-287123-ldkuwcc7 538 32 agent agent NN cord-287123-ldkuwcc7 538 33 : : : cord-287123-ldkuwcc7 539 1 Cflflfk Cflflfk NNP cord-287123-ldkuwcc7 539 2 - - HYPH cord-287123-ldkuwcc7 539 3 peg-64cu peg-64cu VBN cord-287123-ldkuwcc7 539 4 Selective selective JJ cord-287123-ldkuwcc7 539 5 inhibition inhibition NN cord-287123-ldkuwcc7 539 6 of of IN cord-287123-ldkuwcc7 539 7 n n JJ cord-287123-ldkuwcc7 539 8 - - HYPH cord-287123-ldkuwcc7 539 9 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 539 10 - - HYPH cord-287123-ldkuwcc7 539 11 induced induce VBN cord-287123-ldkuwcc7 539 12 neutrophil neutrophil NN cord-287123-ldkuwcc7 539 13 activation activation NN cord-287123-ldkuwcc7 539 14 by by IN cord-287123-ldkuwcc7 539 15 carbamate carbamate NN cord-287123-ldkuwcc7 539 16 - - HYPH cord-287123-ldkuwcc7 539 17 modified modify VBN cord-287123-ldkuwcc7 539 18 peptide peptide JJ cord-287123-ldkuwcc7 539 19 analogues analogue NNS cord-287123-ldkuwcc7 539 20 Antibiotics antibiotic NNS cord-287123-ldkuwcc7 539 21 and and CC cord-287123-ldkuwcc7 539 22 peptides peptide NNS cord-287123-ldkuwcc7 539 23 with with IN cord-287123-ldkuwcc7 539 24 agonist agonist NN cord-287123-ldkuwcc7 539 25 and and CC cord-287123-ldkuwcc7 539 26 antagonist antagonist NN cord-287123-ldkuwcc7 539 27 chemotactic chemotactic JJ cord-287123-ldkuwcc7 539 28 activity activity NN cord-287123-ldkuwcc7 539 29 Cyclosporin Cyclosporin NNP cord-287123-ldkuwcc7 539 30 h h NNP cord-287123-ldkuwcc7 539 31 , , , cord-287123-ldkuwcc7 539 32 boc boc NNP cord-287123-ldkuwcc7 539 33 - - HYPH cord-287123-ldkuwcc7 539 34 mlf mlf NNP cord-287123-ldkuwcc7 539 35 and and CC cord-287123-ldkuwcc7 539 36 boc boc NNP cord-287123-ldkuwcc7 539 37 - - HYPH cord-287123-ldkuwcc7 539 38 flflf flflf NNP cord-287123-ldkuwcc7 539 39 are be VBP cord-287123-ldkuwcc7 539 40 antagonists antagonist NNS cord-287123-ldkuwcc7 539 41 that that WDT cord-287123-ldkuwcc7 539 42 preferentially preferentially RB cord-287123-ldkuwcc7 539 43 inhibit inhibit VBP cord-287123-ldkuwcc7 539 44 activity activity NN cord-287123-ldkuwcc7 539 45 triggered trigger VBN cord-287123-ldkuwcc7 539 46 through through IN cord-287123-ldkuwcc7 539 47 the the DT cord-287123-ldkuwcc7 539 48 formyl formyl NNP cord-287123-ldkuwcc7 539 49 peptide peptide NN cord-287123-ldkuwcc7 539 50 receptor receptor NN cord-287123-ldkuwcc7 539 51 Development Development NNP cord-287123-ldkuwcc7 539 52 of of IN cord-287123-ldkuwcc7 539 53 potent potent JJ cord-287123-ldkuwcc7 539 54 antagonists antagonist NNS cord-287123-ldkuwcc7 539 55 for for IN cord-287123-ldkuwcc7 539 56 formyl formyl NNP cord-287123-ldkuwcc7 539 57 peptide peptide NN cord-287123-ldkuwcc7 539 58 receptor receptor NN cord-287123-ldkuwcc7 539 59 1 1 CD cord-287123-ldkuwcc7 539 60 based base VBN cord-287123-ldkuwcc7 539 61 on on IN cord-287123-ldkuwcc7 539 62 boc boc NNP cord-287123-ldkuwcc7 539 63 - - HYPH cord-287123-ldkuwcc7 539 64 phe phe NNP cord-287123-ldkuwcc7 539 65 - - HYPH cord-287123-ldkuwcc7 539 66 d d JJ cord-287123-ldkuwcc7 539 67 - - HYPH cord-287123-ldkuwcc7 539 68 leu leu JJ cord-287123-ldkuwcc7 539 69 - - HYPH cord-287123-ldkuwcc7 539 70 phe phe NNP cord-287123-ldkuwcc7 539 71 - - HYPH cord-287123-ldkuwcc7 539 72 d d JJ cord-287123-ldkuwcc7 539 73 - - HYPH cord-287123-ldkuwcc7 539 74 leu leu NN cord-287123-ldkuwcc7 539 75 - - HYPH cord-287123-ldkuwcc7 539 76 phe- phe- NNP cord-287123-ldkuwcc7 540 1 oh oh UH cord-287123-ldkuwcc7 540 2 Chemotaxis Chemotaxis NNP cord-287123-ldkuwcc7 540 3 inhibitory inhibitory JJ cord-287123-ldkuwcc7 540 4 protein protein NN cord-287123-ldkuwcc7 540 5 of of IN cord-287123-ldkuwcc7 540 6 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 540 7 aureus aureus NN cord-287123-ldkuwcc7 540 8 binds bind VBZ cord-287123-ldkuwcc7 540 9 specifically specifically RB cord-287123-ldkuwcc7 540 10 to to IN cord-287123-ldkuwcc7 540 11 the the DT cord-287123-ldkuwcc7 540 12 c5a c5a JJ cord-287123-ldkuwcc7 540 13 and and CC cord-287123-ldkuwcc7 540 14 formylated formylated JJ cord-287123-ldkuwcc7 540 15 peptide peptide NN cord-287123-ldkuwcc7 540 16 receptor receptor NN cord-287123-ldkuwcc7 540 17 Characterisation Characterisation NNP cord-287123-ldkuwcc7 540 18 of of IN cord-287123-ldkuwcc7 540 19 receptor receptor NN cord-287123-ldkuwcc7 540 20 binding binding NN cord-287123-ldkuwcc7 540 21 by by IN cord-287123-ldkuwcc7 540 22 the the DT cord-287123-ldkuwcc7 540 23 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 540 24 inhibitory inhibitory JJ cord-287123-ldkuwcc7 540 25 protein protein NN cord-287123-ldkuwcc7 540 26 of of IN cord-287123-ldkuwcc7 540 27 Staphylococcus Staphylococcus NNP cord-287123-ldkuwcc7 540 28 aureus aureus NN cord-287123-ldkuwcc7 540 29 and and CC cord-287123-ldkuwcc7 540 30 the the DT cord-287123-ldkuwcc7 540 31 effects effect NNS cord-287123-ldkuwcc7 540 32 of of IN cord-287123-ldkuwcc7 540 33 the the DT cord-287123-ldkuwcc7 540 34 host host NN cord-287123-ldkuwcc7 540 35 immune immune JJ cord-287123-ldkuwcc7 540 36 response response NN cord-287123-ldkuwcc7 540 37 A a DT cord-287123-ldkuwcc7 540 38 new new JJ cord-287123-ldkuwcc7 540 39 staphylococcal staphylococcal JJ cord-287123-ldkuwcc7 540 40 anti anti JJ cord-287123-ldkuwcc7 540 41 - - JJ cord-287123-ldkuwcc7 540 42 inflammatory inflammatory JJ cord-287123-ldkuwcc7 540 43 protein protein NN cord-287123-ldkuwcc7 540 44 that that WDT cord-287123-ldkuwcc7 540 45 antagonizes antagonize VBZ cord-287123-ldkuwcc7 540 46 the the DT cord-287123-ldkuwcc7 540 47 formyl formyl NNP cord-287123-ldkuwcc7 540 48 peptide peptide NN cord-287123-ldkuwcc7 540 49 receptor receptor NN cord-287123-ldkuwcc7 540 50 - - HYPH cord-287123-ldkuwcc7 540 51 like like JJ cord-287123-ldkuwcc7 540 52 1 1 CD cord-287123-ldkuwcc7 541 1 An an DT cord-287123-ldkuwcc7 541 2 immunosuppressive immunosuppressive JJ cord-287123-ldkuwcc7 541 3 retrovirus retrovirus NN cord-287123-ldkuwcc7 541 4 - - HYPH cord-287123-ldkuwcc7 541 5 derived derive VBN cord-287123-ldkuwcc7 541 6 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 541 7 interferes interfere VBZ cord-287123-ldkuwcc7 541 8 with with IN cord-287123-ldkuwcc7 541 9 intracellular intracellular JJ cord-287123-ldkuwcc7 541 10 signaling signaling NN cord-287123-ldkuwcc7 541 11 in in IN cord-287123-ldkuwcc7 541 12 monocytes monocyte NNS cord-287123-ldkuwcc7 541 13 and and CC cord-287123-ldkuwcc7 541 14 granulocytes granulocyte NNS cord-287123-ldkuwcc7 541 15 through through IN cord-287123-ldkuwcc7 541 16 n n CD cord-287123-ldkuwcc7 541 17 - - HYPH cord-287123-ldkuwcc7 541 18 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 541 19 receptors receptor NNS cord-287123-ldkuwcc7 541 20 Peptides peptide NNS cord-287123-ldkuwcc7 541 21 derived derive VBN cord-287123-ldkuwcc7 541 22 from from IN cord-287123-ldkuwcc7 541 23 HIV-1 HIV-1 NNP cord-287123-ldkuwcc7 541 24 , , , cord-287123-ldkuwcc7 541 25 HIV-2 HIV-2 NNP cord-287123-ldkuwcc7 541 26 , , , cord-287123-ldkuwcc7 541 27 Ebola Ebola NNP cord-287123-ldkuwcc7 541 28 virus virus NN cord-287123-ldkuwcc7 541 29 , , , cord-287123-ldkuwcc7 541 30 SARS SARS NNP cord-287123-ldkuwcc7 541 31 coronavirus coronavirus NN cord-287123-ldkuwcc7 541 32 and and CC cord-287123-ldkuwcc7 541 33 coronavirus coronavirus NN cord-287123-ldkuwcc7 541 34 229E 229e CD cord-287123-ldkuwcc7 541 35 exhibit exhibit VB cord-287123-ldkuwcc7 541 36 high high JJ cord-287123-ldkuwcc7 541 37 affinity affinity NN cord-287123-ldkuwcc7 541 38 binding bind VBG cord-287123-ldkuwcc7 541 39 to to IN cord-287123-ldkuwcc7 541 40 the the DT cord-287123-ldkuwcc7 541 41 formyl formyl NNP cord-287123-ldkuwcc7 541 42 peptide peptide NN cord-287123-ldkuwcc7 541 43 receptor receptor NN cord-287123-ldkuwcc7 541 44 Cyclosporins Cyclosporins NNP cord-287123-ldkuwcc7 541 45 : : : cord-287123-ldkuwcc7 541 46 Structure structure NN cord-287123-ldkuwcc7 541 47 - - HYPH cord-287123-ldkuwcc7 541 48 activity activity NN cord-287123-ldkuwcc7 541 49 relationships relationship NNS cord-287123-ldkuwcc7 541 50 for for IN cord-287123-ldkuwcc7 541 51 the the DT cord-287123-ldkuwcc7 541 52 inhibition inhibition NN cord-287123-ldkuwcc7 541 53 of of IN cord-287123-ldkuwcc7 541 54 the the DT cord-287123-ldkuwcc7 541 55 human human JJ cord-287123-ldkuwcc7 541 56 fpr1 fpr1 NN cord-287123-ldkuwcc7 541 57 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 541 58 receptor receptor NN cord-287123-ldkuwcc7 542 1 The the DT cord-287123-ldkuwcc7 542 2 immunosuppressant immunosuppressant JJ cord-287123-ldkuwcc7 542 3 cyclosporin cyclosporin NN cord-287123-ldkuwcc7 542 4 a a DT cord-287123-ldkuwcc7 542 5 antagonizes antagonize VBZ cord-287123-ldkuwcc7 542 6 human human JJ cord-287123-ldkuwcc7 542 7 formyl formyl NNP cord-287123-ldkuwcc7 542 8 peptide peptide NN cord-287123-ldkuwcc7 542 9 receptor receptor NN cord-287123-ldkuwcc7 542 10 through through IN cord-287123-ldkuwcc7 542 11 inhibition inhibition NN cord-287123-ldkuwcc7 542 12 of of IN cord-287123-ldkuwcc7 542 13 cognate cognate JJ cord-287123-ldkuwcc7 542 14 ligand ligand NN cord-287123-ldkuwcc7 542 15 binding bind VBG cord-287123-ldkuwcc7 542 16 Genetic genetic JJ cord-287123-ldkuwcc7 542 17 ablation ablation NN cord-287123-ldkuwcc7 542 18 of of IN cord-287123-ldkuwcc7 542 19 the the DT cord-287123-ldkuwcc7 542 20 fpr1 fpr1 NN cord-287123-ldkuwcc7 542 21 gene gene NN cord-287123-ldkuwcc7 542 22 confers confer VBZ cord-287123-ldkuwcc7 542 23 protection protection NN cord-287123-ldkuwcc7 542 24 from from IN cord-287123-ldkuwcc7 542 25 smoking smoking NN cord-287123-ldkuwcc7 542 26 - - HYPH cord-287123-ldkuwcc7 542 27 induced induce VBN cord-287123-ldkuwcc7 542 28 lung lung NN cord-287123-ldkuwcc7 542 29 emphysema emphysema NN cord-287123-ldkuwcc7 542 30 in in IN cord-287123-ldkuwcc7 542 31 mice mouse NNS cord-287123-ldkuwcc7 543 1 Mycobacteria Mycobacteria NNP cord-287123-ldkuwcc7 543 2 attenuate attenuate VBP cord-287123-ldkuwcc7 543 3 nociceptive nociceptive JJ cord-287123-ldkuwcc7 543 4 responses response NNS cord-287123-ldkuwcc7 543 5 by by IN cord-287123-ldkuwcc7 543 6 formyl formyl NNP cord-287123-ldkuwcc7 543 7 peptide peptide NN cord-287123-ldkuwcc7 543 8 receptor receptor NN cord-287123-ldkuwcc7 543 9 triggered trigger VBD cord-287123-ldkuwcc7 543 10 opioid opioid JJ cord-287123-ldkuwcc7 543 11 peptide peptide NN cord-287123-ldkuwcc7 543 12 release release NN cord-287123-ldkuwcc7 543 13 from from IN cord-287123-ldkuwcc7 543 14 neutrophils neutrophil NNS cord-287123-ldkuwcc7 543 15 Inhibition Inhibition NNP cord-287123-ldkuwcc7 543 16 of of IN cord-287123-ldkuwcc7 543 17 phagocyte phagocyte NN cord-287123-ldkuwcc7 543 18 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 543 19 by by IN cord-287123-ldkuwcc7 543 20 uteroglobin uteroglobin NNP cord-287123-ldkuwcc7 543 21 , , , cord-287123-ldkuwcc7 543 22 an an DT cord-287123-ldkuwcc7 543 23 inhibitor inhibitor NN cord-287123-ldkuwcc7 543 24 of of IN cord-287123-ldkuwcc7 543 25 blastocyst blastocyst NN cord-287123-ldkuwcc7 543 26 rejection rejection NN cord-287123-ldkuwcc7 543 27 Sodin Sodin NNP cord-287123-ldkuwcc7 543 28 - - HYPH cord-287123-ldkuwcc7 543 29 Semrl Semrl NNP cord-287123-ldkuwcc7 543 30 , , , cord-287123-ldkuwcc7 543 31 S. S. NNP cord-287123-ldkuwcc7 543 32 Uteroglobin Uteroglobin NNP cord-287123-ldkuwcc7 543 33 , , , cord-287123-ldkuwcc7 543 34 a a DT cord-287123-ldkuwcc7 543 35 possible possible JJ cord-287123-ldkuwcc7 543 36 ligand ligand NN cord-287123-ldkuwcc7 543 37 of of IN cord-287123-ldkuwcc7 543 38 the the DT cord-287123-ldkuwcc7 543 39 lipoxin lipoxin NNP cord-287123-ldkuwcc7 543 40 receptor receptor NN cord-287123-ldkuwcc7 543 41 inhibits inhibit VBZ cord-287123-ldkuwcc7 543 42 serum serum NN cord-287123-ldkuwcc7 543 43 amyloid amyloid VB cord-287123-ldkuwcc7 543 44 a a DT cord-287123-ldkuwcc7 543 45 - - HYPH cord-287123-ldkuwcc7 543 46 driven drive VBN cord-287123-ldkuwcc7 543 47 inflammation inflammation NN cord-287123-ldkuwcc7 543 48 Bioactive Bioactive NNP cord-287123-ldkuwcc7 543 49 secondary secondary JJ cord-287123-ldkuwcc7 543 50 metabolites metabolite NNS cord-287123-ldkuwcc7 543 51 of of IN cord-287123-ldkuwcc7 543 52 a a DT cord-287123-ldkuwcc7 543 53 marine marine JJ cord-287123-ldkuwcc7 543 54 bacillus bacillus NN cord-287123-ldkuwcc7 543 55 sp sp NN cord-287123-ldkuwcc7 543 56 . . . cord-287123-ldkuwcc7 544 1 Inhibit inhibit VB cord-287123-ldkuwcc7 544 2 superoxide superoxide NN cord-287123-ldkuwcc7 544 3 generation generation NN cord-287123-ldkuwcc7 544 4 and and CC cord-287123-ldkuwcc7 544 5 elastase elastase NN cord-287123-ldkuwcc7 544 6 release release NN cord-287123-ldkuwcc7 544 7 in in IN cord-287123-ldkuwcc7 544 8 human human JJ cord-287123-ldkuwcc7 544 9 neutrophils neutrophil NNS cord-287123-ldkuwcc7 544 10 by by IN cord-287123-ldkuwcc7 544 11 blocking block VBG cord-287123-ldkuwcc7 544 12 formyl formyl NNP cord-287123-ldkuwcc7 544 13 peptide peptide NN cord-287123-ldkuwcc7 544 14 receptor receptor NN cord-287123-ldkuwcc7 544 15 1 1 CD cord-287123-ldkuwcc7 544 16 . . . cord-287123-ldkuwcc7 545 1 Molecules molecule NNS cord-287123-ldkuwcc7 546 1 The the DT cord-287123-ldkuwcc7 546 2 endogenous endogenous JJ cord-287123-ldkuwcc7 546 3 opioid opioid NN cord-287123-ldkuwcc7 546 4 spinorphin spinorphin NN cord-287123-ldkuwcc7 546 5 blocks block VBZ cord-287123-ldkuwcc7 546 6 fmet fmet NNP cord-287123-ldkuwcc7 546 7 - - HYPH cord-287123-ldkuwcc7 546 8 leu leu NN cord-287123-ldkuwcc7 546 9 - - HYPH cord-287123-ldkuwcc7 546 10 phe phe NN cord-287123-ldkuwcc7 546 11 - - HYPH cord-287123-ldkuwcc7 546 12 induced induce VBN cord-287123-ldkuwcc7 546 13 neutrophil neutrophil NN cord-287123-ldkuwcc7 546 14 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 546 15 by by IN cord-287123-ldkuwcc7 546 16 acting act VBG cord-287123-ldkuwcc7 546 17 as as IN cord-287123-ldkuwcc7 546 18 a a DT cord-287123-ldkuwcc7 546 19 specific specific JJ cord-287123-ldkuwcc7 546 20 antagonist antagonist NN cord-287123-ldkuwcc7 546 21 at at IN cord-287123-ldkuwcc7 546 22 the the DT cord-287123-ldkuwcc7 546 23 n n JJ cord-287123-ldkuwcc7 546 24 - - HYPH cord-287123-ldkuwcc7 546 25 formylpeptide formylpeptide NNP cord-287123-ldkuwcc7 546 26 receptor receptor NN cord-287123-ldkuwcc7 546 27 subtype subtype NN cord-287123-ldkuwcc7 546 28 fpr fpr NNP cord-287123-ldkuwcc7 546 29 Two two CD cord-287123-ldkuwcc7 546 30 trypanocidal trypanocidal NN cord-287123-ldkuwcc7 546 31 dipeptides dipeptide VBZ cord-287123-ldkuwcc7 546 32 from from IN cord-287123-ldkuwcc7 546 33 the the DT cord-287123-ldkuwcc7 546 34 roots root NNS cord-287123-ldkuwcc7 546 35 of of IN cord-287123-ldkuwcc7 546 36 zapoteca zapoteca NNP cord-287123-ldkuwcc7 546 37 portoricensis portoricensis NNP cord-287123-ldkuwcc7 546 38 ( ( -LRB- cord-287123-ldkuwcc7 546 39 fabaceae fabaceae NN cord-287123-ldkuwcc7 546 40 ) ) -RRB- cord-287123-ldkuwcc7 546 41 Inhibitory inhibitory JJ cord-287123-ldkuwcc7 546 42 effects effect NNS cord-287123-ldkuwcc7 546 43 of of IN cord-287123-ldkuwcc7 546 44 spinorphin spinorphin NNP cord-287123-ldkuwcc7 546 45 , , , cord-287123-ldkuwcc7 546 46 a a DT cord-287123-ldkuwcc7 546 47 novel novel JJ cord-287123-ldkuwcc7 546 48 endogenous endogenous JJ cord-287123-ldkuwcc7 546 49 regulator regulator NN cord-287123-ldkuwcc7 546 50 , , , cord-287123-ldkuwcc7 546 51 on on IN cord-287123-ldkuwcc7 546 52 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 546 53 , , , cord-287123-ldkuwcc7 546 54 o2-generation o2-generation NN cord-287123-ldkuwcc7 546 55 , , , cord-287123-ldkuwcc7 546 56 and and CC cord-287123-ldkuwcc7 546 57 exocytosis exocytosis NN cord-287123-ldkuwcc7 546 58 by by IN cord-287123-ldkuwcc7 546 59 n n JJ cord-287123-ldkuwcc7 546 60 - - HYPH cord-287123-ldkuwcc7 546 61 formylmethionylleucyl formylmethionylleucyl NN cord-287123-ldkuwcc7 546 62 - - HYPH cord-287123-ldkuwcc7 546 63 phenylalanine phenylalanine NN cord-287123-ldkuwcc7 546 64 ( ( -LRB- cord-287123-ldkuwcc7 546 65 fmlp)-stimulated fmlp)-stimulated JJ cord-287123-ldkuwcc7 546 66 neutrophils neutrophil NNS cord-287123-ldkuwcc7 546 67 Constituents constituent NNS cord-287123-ldkuwcc7 546 68 and and CC cord-287123-ldkuwcc7 546 69 bioactive bioactive JJ cord-287123-ldkuwcc7 546 70 principles principle NNS cord-287123-ldkuwcc7 546 71 of of IN cord-287123-ldkuwcc7 546 72 polygonum polygonum NN cord-287123-ldkuwcc7 546 73 chinensis chinensis NNP cord-287123-ldkuwcc7 546 74 Design Design NNP cord-287123-ldkuwcc7 546 75 and and CC cord-287123-ldkuwcc7 546 76 synthesis synthesis NN cord-287123-ldkuwcc7 546 77 of of IN cord-287123-ldkuwcc7 546 78 new new JJ cord-287123-ldkuwcc7 546 79 n-(fluorenyl-9-methoxycarbonyl n-(fluorenyl-9-methoxycarbonyl NNP cord-287123-ldkuwcc7 546 80 ) ) -RRB- cord-287123-ldkuwcc7 547 1 ( ( -LRB- cord-287123-ldkuwcc7 547 2 fmoc)-dipeptides fmoc)-dipeptide NNS cord-287123-ldkuwcc7 547 3 as as IN cord-287123-ldkuwcc7 547 4 anti anti JJ cord-287123-ldkuwcc7 547 5 - - JJ cord-287123-ldkuwcc7 547 6 inflammatory inflammatory JJ cord-287123-ldkuwcc7 547 7 agents agent NNS cord-287123-ldkuwcc7 547 8 Design design NN cord-287123-ldkuwcc7 547 9 and and CC cord-287123-ldkuwcc7 547 10 synthesis synthesis NN cord-287123-ldkuwcc7 547 11 of of IN cord-287123-ldkuwcc7 547 12 tryptophan tryptophan NN cord-287123-ldkuwcc7 547 13 containing contain VBG cord-287123-ldkuwcc7 547 14 dipeptide dipeptide JJ cord-287123-ldkuwcc7 547 15 derivatives derivative NNS cord-287123-ldkuwcc7 547 16 as as IN cord-287123-ldkuwcc7 547 17 formyl formyl NNP cord-287123-ldkuwcc7 547 18 peptide peptide NN cord-287123-ldkuwcc7 547 19 receptor receptor NN cord-287123-ldkuwcc7 547 20 1 1 CD cord-287123-ldkuwcc7 547 21 antagonist antagonist NN cord-287123-ldkuwcc7 547 22 Trp trp NN cord-287123-ldkuwcc7 547 23 - - HYPH cord-287123-ldkuwcc7 547 24 arg arg JJ cord-287123-ldkuwcc7 547 25 - - HYPH cord-287123-ldkuwcc7 547 26 trp trp NN cord-287123-ldkuwcc7 547 27 - - HYPH cord-287123-ldkuwcc7 547 28 trp trp NN cord-287123-ldkuwcc7 547 29 - - HYPH cord-287123-ldkuwcc7 547 30 trp trp NN cord-287123-ldkuwcc7 547 31 - - HYPH cord-287123-ldkuwcc7 547 32 trp trp NN cord-287123-ldkuwcc7 547 33 antagonizes antagonize VBZ cord-287123-ldkuwcc7 547 34 formyl formyl NNP cord-287123-ldkuwcc7 547 35 peptide peptide NN cord-287123-ldkuwcc7 547 36 receptor receptor NN cord-287123-ldkuwcc7 547 37 like like IN cord-287123-ldkuwcc7 548 1 2-mediated 2-mediated CD cord-287123-ldkuwcc7 548 2 signaling signal VBG cord-287123-ldkuwcc7 548 3 Receptor receptor NN cord-287123-ldkuwcc7 548 4 - - HYPH cord-287123-ldkuwcc7 548 5 directed direct VBN cord-287123-ldkuwcc7 548 6 inhibition inhibition NN cord-287123-ldkuwcc7 548 7 of of IN cord-287123-ldkuwcc7 548 8 chemotactic chemotactic JJ cord-287123-ldkuwcc7 548 9 factor factor NN cord-287123-ldkuwcc7 548 10 - - HYPH cord-287123-ldkuwcc7 548 11 induced induce VBN cord-287123-ldkuwcc7 548 12 neutrophil neutrophil NN cord-287123-ldkuwcc7 548 13 hyperactivity hyperactivity NN cord-287123-ldkuwcc7 548 14 by by IN cord-287123-ldkuwcc7 548 15 pyrazolon pyrazolon NN cord-287123-ldkuwcc7 548 16 derivatives derivative NNS cord-287123-ldkuwcc7 548 17 . . . cord-287123-ldkuwcc7 549 1 Definition definition NN cord-287123-ldkuwcc7 549 2 of of IN cord-287123-ldkuwcc7 549 3 a a DT cord-287123-ldkuwcc7 549 4 chemotactic chemotactic JJ cord-287123-ldkuwcc7 549 5 peptide peptide NN cord-287123-ldkuwcc7 549 6 antagonist antagonist NN cord-287123-ldkuwcc7 550 1 The the DT cord-287123-ldkuwcc7 550 2 interaction interaction NN cord-287123-ldkuwcc7 550 3 of of IN cord-287123-ldkuwcc7 550 4 3,5-pyrazolidinedione 3,5-pyrazolidinedione CD cord-287123-ldkuwcc7 550 5 drugs drug NNS cord-287123-ldkuwcc7 550 6 with with IN cord-287123-ldkuwcc7 550 7 receptors receptor NNS cord-287123-ldkuwcc7 550 8 for for IN cord-287123-ldkuwcc7 550 9 f f LS cord-287123-ldkuwcc7 550 10 - - HYPH cord-287123-ldkuwcc7 550 11 met meet VBN cord-287123-ldkuwcc7 550 12 - - HYPH cord-287123-ldkuwcc7 550 13 leu leu NN cord-287123-ldkuwcc7 550 14 - - HYPH cord-287123-ldkuwcc7 550 15 phe phe NNP cord-287123-ldkuwcc7 550 16 on on IN cord-287123-ldkuwcc7 550 17 human human JJ cord-287123-ldkuwcc7 550 18 neutrophil neutrophil NN cord-287123-ldkuwcc7 550 19 leukocytes leukocyte NNS cord-287123-ldkuwcc7 550 20 : : : cord-287123-ldkuwcc7 550 21 A a DT cord-287123-ldkuwcc7 550 22 study study NN cord-287123-ldkuwcc7 550 23 of of IN cord-287123-ldkuwcc7 550 24 the the DT cord-287123-ldkuwcc7 550 25 structure structure NN cord-287123-ldkuwcc7 550 26 - - HYPH cord-287123-ldkuwcc7 550 27 activity activity NN cord-287123-ldkuwcc7 550 28 relationship relationship NN cord-287123-ldkuwcc7 550 29 . . . cord-287123-ldkuwcc7 551 1 Can Can MD cord-287123-ldkuwcc7 551 2 Inhibition inhibition NN cord-287123-ldkuwcc7 551 3 of of IN cord-287123-ldkuwcc7 551 4 human human JJ cord-287123-ldkuwcc7 551 5 platelet platelet NN cord-287123-ldkuwcc7 551 6 cyclo cyclo NN cord-287123-ldkuwcc7 551 7 - - HYPH cord-287123-ldkuwcc7 551 8 oxygenase oxygenase NN cord-287123-ldkuwcc7 551 9 activity activity NN cord-287123-ldkuwcc7 551 10 by by IN cord-287123-ldkuwcc7 551 11 sulfinpyrazone sulfinpyrazone NNP cord-287123-ldkuwcc7 551 12 and and CC cord-287123-ldkuwcc7 551 13 three three CD cord-287123-ldkuwcc7 551 14 of of IN cord-287123-ldkuwcc7 551 15 its -PRON- PRP$ cord-287123-ldkuwcc7 551 16 metabolites metabolite NNS cord-287123-ldkuwcc7 551 17 High high JJ cord-287123-ldkuwcc7 551 18 - - HYPH cord-287123-ldkuwcc7 551 19 throughput throughput NN cord-287123-ldkuwcc7 551 20 screening screening NN cord-287123-ldkuwcc7 551 21 with with IN cord-287123-ldkuwcc7 551 22 hypercyt hypercyt NN cord-287123-ldkuwcc7 551 23 flow flow NN cord-287123-ldkuwcc7 551 24 cytometry cytometry NN cord-287123-ldkuwcc7 551 25 to to TO cord-287123-ldkuwcc7 551 26 detect detect VB cord-287123-ldkuwcc7 551 27 small small JJ cord-287123-ldkuwcc7 551 28 molecule molecule NN cord-287123-ldkuwcc7 551 29 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 551 30 receptor receptor NN cord-287123-ldkuwcc7 551 31 ligands ligand NNS cord-287123-ldkuwcc7 552 1 The the DT cord-287123-ldkuwcc7 552 2 hederagenin hederagenin NNP cord-287123-ldkuwcc7 552 3 saponin saponin NN cord-287123-ldkuwcc7 553 1 smg-1 smg-1 NNP cord-287123-ldkuwcc7 553 2 is be VBZ cord-287123-ldkuwcc7 553 3 a a DT cord-287123-ldkuwcc7 553 4 natural natural JJ cord-287123-ldkuwcc7 553 5 fmlp fmlp NNP cord-287123-ldkuwcc7 553 6 receptor receptor NN cord-287123-ldkuwcc7 553 7 inhibitor inhibitor NN cord-287123-ldkuwcc7 553 8 that that WDT cord-287123-ldkuwcc7 553 9 suppresses suppress VBZ cord-287123-ldkuwcc7 553 10 human human JJ cord-287123-ldkuwcc7 553 11 neutrophil neutrophil NN cord-287123-ldkuwcc7 553 12 activation activation NN cord-287123-ldkuwcc7 553 13 Antagonism Antagonism NNP cord-287123-ldkuwcc7 553 14 of of IN cord-287123-ldkuwcc7 553 15 human human NNP cord-287123-ldkuwcc7 553 16 formyl formyl NNP cord-287123-ldkuwcc7 553 17 peptide peptide NN cord-287123-ldkuwcc7 553 18 receptor receptor NN cord-287123-ldkuwcc7 553 19 1 1 CD cord-287123-ldkuwcc7 553 20 with with IN cord-287123-ldkuwcc7 553 21 natural natural JJ cord-287123-ldkuwcc7 553 22 compounds compound NNS cord-287123-ldkuwcc7 553 23 and and CC cord-287123-ldkuwcc7 553 24 their -PRON- PRP$ cord-287123-ldkuwcc7 553 25 synthetic synthetic JJ cord-287123-ldkuwcc7 553 26 derivatives derivative NNS cord-287123-ldkuwcc7 553 27 2r,3r)-2-(3 2r,3r)-2-(3 CD cord-287123-ldkuwcc7 553 28 , , , cord-287123-ldkuwcc7 553 29 4 4 CD cord-287123-ldkuwcc7 553 30 -dihydroxybenzyl)-3-(3 -dihydroxybenzyl)-3-(3 NNP cord-287123-ldkuwcc7 553 31 , , , cord-287123-ldkuwcc7 553 32 4 4 CD cord-287123-ldkuwcc7 553 33 -dimethoxybenzyl)butyrolactone -dimethoxybenzyl)butyrolactone NNP cord-287123-ldkuwcc7 553 34 suppresses suppress VBZ cord-287123-ldkuwcc7 553 35 fmlp fmlp NN cord-287123-ldkuwcc7 553 36 - - HYPH cord-287123-ldkuwcc7 553 37 induced induce VBN cord-287123-ldkuwcc7 553 38 superoxide superoxide NN cord-287123-ldkuwcc7 553 39 production production NN cord-287123-ldkuwcc7 553 40 by by IN cord-287123-ldkuwcc7 553 41 inhibiting inhibit VBG cord-287123-ldkuwcc7 553 42 fmlp fmlp NNP cord-287123-ldkuwcc7 553 43 - - HYPH cord-287123-ldkuwcc7 553 44 receptor receptor NN cord-287123-ldkuwcc7 553 45 binding binding NN cord-287123-ldkuwcc7 553 46 in in IN cord-287123-ldkuwcc7 553 47 human human JJ cord-287123-ldkuwcc7 553 48 neutrophils neutrophil NNS cord-287123-ldkuwcc7 553 49 High high JJ cord-287123-ldkuwcc7 553 50 - - HYPH cord-287123-ldkuwcc7 553 51 content content NN cord-287123-ldkuwcc7 553 52 screening screening NN cord-287123-ldkuwcc7 553 53 : : : cord-287123-ldkuwcc7 553 54 Flow flow NN cord-287123-ldkuwcc7 553 55 cytometry cytometry NN cord-287123-ldkuwcc7 553 56 analysis analysis NN cord-287123-ldkuwcc7 553 57 Biomolecular biomolecular JJ cord-287123-ldkuwcc7 553 58 screening screening NN cord-287123-ldkuwcc7 553 59 of of IN cord-287123-ldkuwcc7 553 60 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 553 61 receptor receptor NN cord-287123-ldkuwcc7 553 62 ligands ligand NNS cord-287123-ldkuwcc7 553 63 with with IN cord-287123-ldkuwcc7 553 64 a a DT cord-287123-ldkuwcc7 553 65 sensitive sensitive JJ cord-287123-ldkuwcc7 553 66 , , , cord-287123-ldkuwcc7 553 67 quantitative quantitative JJ cord-287123-ldkuwcc7 553 68 , , , cord-287123-ldkuwcc7 553 69 high high JJ cord-287123-ldkuwcc7 553 70 - - HYPH cord-287123-ldkuwcc7 553 71 throughput throughput NN cord-287123-ldkuwcc7 553 72 flow flow NN cord-287123-ldkuwcc7 553 73 cytometry cytometry NN cord-287123-ldkuwcc7 553 74 platform platform NN cord-287123-ldkuwcc7 554 1 A a DT cord-287123-ldkuwcc7 554 2 novel novel JJ cord-287123-ldkuwcc7 554 3 fluorescent fluorescent NN cord-287123-ldkuwcc7 554 4 cross cross JJ cord-287123-ldkuwcc7 554 5 - - JJ cord-287123-ldkuwcc7 554 6 reactive reactive JJ cord-287123-ldkuwcc7 554 7 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 554 8 receptor receptor NN cord-287123-ldkuwcc7 554 9 / / SYM cord-287123-ldkuwcc7 554 10 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 554 11 receptor receptor NN cord-287123-ldkuwcc7 554 12 - - : cord-287123-ldkuwcc7 554 13 like like JJ cord-287123-ldkuwcc7 554 14 1 1 CD cord-287123-ldkuwcc7 554 15 hexapeptide hexapeptide NN cord-287123-ldkuwcc7 554 16 ligand ligand NN cord-287123-ldkuwcc7 554 17 Duplex Duplex NNP cord-287123-ldkuwcc7 554 18 high high JJ cord-287123-ldkuwcc7 554 19 - - HYPH cord-287123-ldkuwcc7 554 20 throughput throughput NN cord-287123-ldkuwcc7 554 21 flow flow NN cord-287123-ldkuwcc7 554 22 cytometry cytometry NN cord-287123-ldkuwcc7 554 23 screen screen NN cord-287123-ldkuwcc7 554 24 identifies identify VBZ cord-287123-ldkuwcc7 554 25 two two CD cord-287123-ldkuwcc7 554 26 novel novel JJ cord-287123-ldkuwcc7 554 27 formylpeptide formylpeptide NNP cord-287123-ldkuwcc7 554 28 receptor receptor NNP cord-287123-ldkuwcc7 554 29 family family NN cord-287123-ldkuwcc7 554 30 probes probe VBZ cord-287123-ldkuwcc7 554 31 Multiple multiple JJ cord-287123-ldkuwcc7 554 32 domains domain NNS cord-287123-ldkuwcc7 554 33 of of IN cord-287123-ldkuwcc7 554 34 the the DT cord-287123-ldkuwcc7 554 35 n n NNP cord-287123-ldkuwcc7 554 36 - - HYPH cord-287123-ldkuwcc7 554 37 formyl formyl NNP cord-287123-ldkuwcc7 554 38 peptide peptide NN cord-287123-ldkuwcc7 554 39 receptor receptor NN cord-287123-ldkuwcc7 554 40 are be VBP cord-287123-ldkuwcc7 554 41 required require VBN cord-287123-ldkuwcc7 554 42 for for IN cord-287123-ldkuwcc7 554 43 high high JJ cord-287123-ldkuwcc7 554 44 - - HYPH cord-287123-ldkuwcc7 554 45 affinity affinity NN cord-287123-ldkuwcc7 554 46 ligand ligand NN cord-287123-ldkuwcc7 554 47 binding binding NN cord-287123-ldkuwcc7 554 48 . . . cord-287123-ldkuwcc7 555 1 Construction construction NN cord-287123-ldkuwcc7 555 2 and and CC cord-287123-ldkuwcc7 555 3 analysis analysis NN cord-287123-ldkuwcc7 555 4 of of IN cord-287123-ldkuwcc7 555 5 chimeric chimeric JJ cord-287123-ldkuwcc7 555 6 n n NNP cord-287123-ldkuwcc7 555 7 - - HYPH cord-287123-ldkuwcc7 555 8 formyl formyl NNP cord-287123-ldkuwcc7 555 9 peptide peptide NN cord-287123-ldkuwcc7 555 10 receptors receptor NNS cord-287123-ldkuwcc7 555 11 Species specie NNS cord-287123-ldkuwcc7 555 12 and and CC cord-287123-ldkuwcc7 555 13 subtype subtype NN cord-287123-ldkuwcc7 555 14 variants variant NNS cord-287123-ldkuwcc7 555 15 of of IN cord-287123-ldkuwcc7 555 16 the the DT cord-287123-ldkuwcc7 555 17 n n NNP cord-287123-ldkuwcc7 555 18 - - HYPH cord-287123-ldkuwcc7 555 19 formyl formyl NNP cord-287123-ldkuwcc7 555 20 peptide peptide NN cord-287123-ldkuwcc7 555 21 chemotactic chemotactic JJ cord-287123-ldkuwcc7 555 22 receptor receptor NN cord-287123-ldkuwcc7 555 23 reveal reveal VBP cord-287123-ldkuwcc7 555 24 multiple multiple JJ cord-287123-ldkuwcc7 555 25 important important JJ cord-287123-ldkuwcc7 555 26 functional functional JJ cord-287123-ldkuwcc7 555 27 domains domain NNS cord-287123-ldkuwcc7 555 28 Identification identification NN cord-287123-ldkuwcc7 555 29 of of IN cord-287123-ldkuwcc7 555 30 functional functional JJ cord-287123-ldkuwcc7 555 31 domains domain NNS cord-287123-ldkuwcc7 555 32 in in IN cord-287123-ldkuwcc7 555 33 the the DT cord-287123-ldkuwcc7 555 34 formyl formyl NNP cord-287123-ldkuwcc7 555 35 peptide peptide NN cord-287123-ldkuwcc7 555 36 receptor receptor NN cord-287123-ldkuwcc7 555 37 - - HYPH cord-287123-ldkuwcc7 555 38 like like JJ cord-287123-ldkuwcc7 555 39 1 1 CD cord-287123-ldkuwcc7 555 40 for for IN cord-287123-ldkuwcc7 555 41 agonist agonist NN cord-287123-ldkuwcc7 555 42 - - HYPH cord-287123-ldkuwcc7 555 43 induced induce VBN cord-287123-ldkuwcc7 555 44 cell cell NN cord-287123-ldkuwcc7 555 45 chemotaxis chemotaxis NN cord-287123-ldkuwcc7 556 1 The the DT cord-287123-ldkuwcc7 556 2 ligand ligand NN cord-287123-ldkuwcc7 556 3 binding bind VBG cord-287123-ldkuwcc7 556 4 site site NN cord-287123-ldkuwcc7 556 5 of of IN cord-287123-ldkuwcc7 556 6 the the DT cord-287123-ldkuwcc7 556 7 formyl formyl NNP cord-287123-ldkuwcc7 556 8 peptide peptide NN cord-287123-ldkuwcc7 556 9 receptor receptor NN cord-287123-ldkuwcc7 556 10 maps map NNS cord-287123-ldkuwcc7 556 11 in in IN cord-287123-ldkuwcc7 556 12 the the DT cord-287123-ldkuwcc7 556 13 transmembrane transmembrane NNP cord-287123-ldkuwcc7 556 14 region region NN cord-287123-ldkuwcc7 556 15 Identification identification NN cord-287123-ldkuwcc7 556 16 of of IN cord-287123-ldkuwcc7 556 17 an an DT cord-287123-ldkuwcc7 556 18 n n NNP cord-287123-ldkuwcc7 556 19 - - HYPH cord-287123-ldkuwcc7 556 20 formyl formyl NN cord-287123-ldkuwcc7 556 21 peptide peptide NN cord-287123-ldkuwcc7 556 22 receptor receptor NN cord-287123-ldkuwcc7 556 23 ligand ligand NN cord-287123-ldkuwcc7 556 24 binding bind VBG cord-287123-ldkuwcc7 556 25 domain domain NN cord-287123-ldkuwcc7 556 26 by by IN cord-287123-ldkuwcc7 556 27 a a DT cord-287123-ldkuwcc7 556 28 gain gain NN cord-287123-ldkuwcc7 556 29 - - HYPH cord-287123-ldkuwcc7 556 30 of of IN cord-287123-ldkuwcc7 556 31 - - HYPH cord-287123-ldkuwcc7 556 32 function function NN cord-287123-ldkuwcc7 556 33 approach approach NN cord-287123-ldkuwcc7 556 34 Human Human NNP cord-287123-ldkuwcc7 556 35 formyl formyl NNP cord-287123-ldkuwcc7 556 36 peptide peptide NN cord-287123-ldkuwcc7 556 37 receptor receptor NN cord-287123-ldkuwcc7 556 38 function function NN cord-287123-ldkuwcc7 556 39 role role NN cord-287123-ldkuwcc7 556 40 of of IN cord-287123-ldkuwcc7 556 41 conserved conserved JJ cord-287123-ldkuwcc7 556 42 and and CC cord-287123-ldkuwcc7 556 43 nonconserved nonconserved JJ cord-287123-ldkuwcc7 556 44 charged charge VBD cord-287123-ldkuwcc7 556 45 residues residue NNS cord-287123-ldkuwcc7 556 46 Characterization characterization NN cord-287123-ldkuwcc7 556 47 of of IN cord-287123-ldkuwcc7 556 48 the the DT cord-287123-ldkuwcc7 556 49 binding binding NN cord-287123-ldkuwcc7 556 50 site site NN cord-287123-ldkuwcc7 556 51 on on IN cord-287123-ldkuwcc7 556 52 the the DT cord-287123-ldkuwcc7 556 53 formyl formyl NNP cord-287123-ldkuwcc7 556 54 peptide peptide NN cord-287123-ldkuwcc7 556 55 receptor receptor NN cord-287123-ldkuwcc7 556 56 using use VBG cord-287123-ldkuwcc7 556 57 three three CD cord-287123-ldkuwcc7 556 58 receptor receptor NN cord-287123-ldkuwcc7 556 59 mutants mutant NNS cord-287123-ldkuwcc7 556 60 and and CC cord-287123-ldkuwcc7 556 61 analogs analog NNS cord-287123-ldkuwcc7 556 62 of of IN cord-287123-ldkuwcc7 556 63 met meet VBN cord-287123-ldkuwcc7 556 64 - - HYPH cord-287123-ldkuwcc7 556 65 leu leu NN cord-287123-ldkuwcc7 556 66 - - HYPH cord-287123-ldkuwcc7 556 67 phe phe NNP cord-287123-ldkuwcc7 556 68 and and CC cord-287123-ldkuwcc7 556 69 met meet VBN cord-287123-ldkuwcc7 556 70 - - HYPH cord-287123-ldkuwcc7 556 71 met meet VBN cord-287123-ldkuwcc7 556 72 - - HYPH cord-287123-ldkuwcc7 556 73 trp trp NN cord-287123-ldkuwcc7 556 74 - - HYPH cord-287123-ldkuwcc7 556 75 leu leu NNP cord-287123-ldkuwcc7 556 76 - - HYPH cord-287123-ldkuwcc7 556 77 leu leu NNP cord-287123-ldkuwcc7 556 78 Identification Identification NNP cord-287123-ldkuwcc7 556 79 of of IN cord-287123-ldkuwcc7 556 80 a a DT cord-287123-ldkuwcc7 556 81 ligand ligand NN cord-287123-ldkuwcc7 556 82 binding binding NN cord-287123-ldkuwcc7 556 83 site site NN cord-287123-ldkuwcc7 556 84 in in IN cord-287123-ldkuwcc7 556 85 the the DT cord-287123-ldkuwcc7 556 86 human human JJ cord-287123-ldkuwcc7 556 87 neutrophil neutrophil NNP cord-287123-ldkuwcc7 556 88 formyl formyl NNP cord-287123-ldkuwcc7 556 89 peptide peptide NN cord-287123-ldkuwcc7 556 90 receptor receptor NN cord-287123-ldkuwcc7 556 91 using use VBG cord-287123-ldkuwcc7 556 92 a a DT cord-287123-ldkuwcc7 556 93 site site NN cord-287123-ldkuwcc7 556 94 - - HYPH cord-287123-ldkuwcc7 556 95 specific specific JJ cord-287123-ldkuwcc7 556 96 fluorescent fluorescent JJ cord-287123-ldkuwcc7 556 97 photoaffinity photoaffinity NN cord-287123-ldkuwcc7 556 98 label label NN cord-287123-ldkuwcc7 556 99 and and CC cord-287123-ldkuwcc7 556 100 mass mass NN cord-287123-ldkuwcc7 556 101 spectrometry spectrometry NN cord-287123-ldkuwcc7 556 102 Ligand ligand NN cord-287123-ldkuwcc7 556 103 - - HYPH cord-287123-ldkuwcc7 556 104 specific specific JJ cord-287123-ldkuwcc7 556 105 regulation regulation NN cord-287123-ldkuwcc7 556 106 of of IN cord-287123-ldkuwcc7 556 107 the the DT cord-287123-ldkuwcc7 556 108 extracellular extracellular JJ cord-287123-ldkuwcc7 556 109 surface surface NN cord-287123-ldkuwcc7 556 110 of of IN cord-287123-ldkuwcc7 556 111 a a DT cord-287123-ldkuwcc7 556 112 g g NN cord-287123-ldkuwcc7 556 113 - - HYPH cord-287123-ldkuwcc7 556 114 protein protein NN cord-287123-ldkuwcc7 556 115 - - HYPH cord-287123-ldkuwcc7 556 116 coupled couple VBN cord-287123-ldkuwcc7 556 117 receptor receptor NN cord-287123-ldkuwcc7 557 1 Linking link VBG cord-287123-ldkuwcc7 557 2 agonist agonist NN cord-287123-ldkuwcc7 557 3 binding bind VBG cord-287123-ldkuwcc7 557 4 to to IN cord-287123-ldkuwcc7 557 5 histamine histamine NN cord-287123-ldkuwcc7 557 6 h1 h1 NNP cord-287123-ldkuwcc7 557 7 receptor receptor NN cord-287123-ldkuwcc7 557 8 activation activation NN cord-287123-ldkuwcc7 557 9 Insight Insight NNP cord-287123-ldkuwcc7 557 10 into into IN cord-287123-ldkuwcc7 557 11 structure structure NN cord-287123-ldkuwcc7 557 12 - - HYPH cord-287123-ldkuwcc7 557 13 function function NN cord-287123-ldkuwcc7 557 14 relationship relationship NN cord-287123-ldkuwcc7 557 15 in in IN cord-287123-ldkuwcc7 557 16 phenol phenol NN cord-287123-ldkuwcc7 557 17 - - HYPH cord-287123-ldkuwcc7 557 18 soluble soluble JJ cord-287123-ldkuwcc7 557 19 modulins modulin NNS cord-287123-ldkuwcc7 557 20 using use VBG cord-287123-ldkuwcc7 557 21 an an DT cord-287123-ldkuwcc7 557 22 alanine alanine JJ cord-287123-ldkuwcc7 557 23 screen screen NN cord-287123-ldkuwcc7 557 24 of of IN cord-287123-ldkuwcc7 557 25 the the DT cord-287123-ldkuwcc7 557 26 phenol phenol NN cord-287123-ldkuwcc7 557 27 - - HYPH cord-287123-ldkuwcc7 557 28 soluble soluble JJ cord-287123-ldkuwcc7 557 29 modulin modulin NN cord-287123-ldkuwcc7 558 1 ( ( -LRB- cord-287123-ldkuwcc7 558 2 psm psm NNP cord-287123-ldkuwcc7 558 3 ) ) -RRB- cord-287123-ldkuwcc7 558 4 alpha3 alpha3 NNP cord-287123-ldkuwcc7 558 5 peptide peptide NN cord-287123-ldkuwcc7 558 6 Peptide Peptide NNP cord-287123-ldkuwcc7 558 7 length length NN cord-287123-ldkuwcc7 558 8 and and CC cord-287123-ldkuwcc7 558 9 folding folding NN cord-287123-ldkuwcc7 558 10 state state NN cord-287123-ldkuwcc7 558 11 govern govern VBP cord-287123-ldkuwcc7 558 12 the the DT cord-287123-ldkuwcc7 558 13 capacity capacity NN cord-287123-ldkuwcc7 558 14 of of IN cord-287123-ldkuwcc7 558 15 staphylococcal staphylococcal JJ cord-287123-ldkuwcc7 558 16 beta beta NN cord-287123-ldkuwcc7 558 17 - - HYPH cord-287123-ldkuwcc7 558 18 type type NN cord-287123-ldkuwcc7 558 19 phenol phenol NN cord-287123-ldkuwcc7 558 20 - - HYPH cord-287123-ldkuwcc7 558 21 soluble soluble JJ cord-287123-ldkuwcc7 558 22 modulins modulin NNS cord-287123-ldkuwcc7 558 23 to to TO cord-287123-ldkuwcc7 558 24 activate activate VB cord-287123-ldkuwcc7 559 1 human human NNP cord-287123-ldkuwcc7 559 2 formyl formyl NNP cord-287123-ldkuwcc7 559 3 - - HYPH cord-287123-ldkuwcc7 559 4 peptide peptide NN cord-287123-ldkuwcc7 559 5 receptors receptor NNS cord-287123-ldkuwcc7 559 6 1 1 CD cord-287123-ldkuwcc7 559 7 or or CC cord-287123-ldkuwcc7 559 8 2 2 CD cord-287123-ldkuwcc7 559 9 Activation Activation NNP cord-287123-ldkuwcc7 559 10 of of IN cord-287123-ldkuwcc7 559 11 lipoxin lipoxin NNP cord-287123-ldkuwcc7 559 12 a(4 a(4 NNP cord-287123-ldkuwcc7 559 13 ) ) -RRB- cord-287123-ldkuwcc7 559 14 receptors receptor NNS cord-287123-ldkuwcc7 559 15 by by IN cord-287123-ldkuwcc7 559 16 aspirin aspirin NN cord-287123-ldkuwcc7 559 17 - - HYPH cord-287123-ldkuwcc7 559 18 triggered trigger VBN cord-287123-ldkuwcc7 559 19 lipoxins lipoxin NNS cord-287123-ldkuwcc7 559 20 and and CC cord-287123-ldkuwcc7 559 21 select select JJ cord-287123-ldkuwcc7 559 22 peptides peptide NNS cord-287123-ldkuwcc7 559 23 evokes evoke VBZ cord-287123-ldkuwcc7 559 24 ligand ligand NN cord-287123-ldkuwcc7 559 25 - - HYPH cord-287123-ldkuwcc7 559 26 specific specific JJ cord-287123-ldkuwcc7 559 27 responses response NNS cord-287123-ldkuwcc7 559 28 in in IN cord-287123-ldkuwcc7 559 29 inflammation inflammation NN cord-287123-ldkuwcc7 560 1 The the DT cord-287123-ldkuwcc7 560 2 annexin annexin NN cord-287123-ldkuwcc7 561 1 i i PRP cord-287123-ldkuwcc7 561 2 sequence sequence VBP cord-287123-ldkuwcc7 561 3 gln(9)-ala(10)-trp(11)-phe(12 gln(9)-ala(10)-trp(11)-phe(12 NNP cord-287123-ldkuwcc7 561 4 ) ) -RRB- cord-287123-ldkuwcc7 562 1 is be VBZ cord-287123-ldkuwcc7 562 2 a a DT cord-287123-ldkuwcc7 562 3 core core NN cord-287123-ldkuwcc7 562 4 structure structure NN cord-287123-ldkuwcc7 562 5 for for IN cord-287123-ldkuwcc7 562 6 interaction interaction NN cord-287123-ldkuwcc7 562 7 with with IN cord-287123-ldkuwcc7 562 8 the the DT cord-287123-ldkuwcc7 562 9 formyl formyl NNP cord-287123-ldkuwcc7 562 10 peptide peptide NN cord-287123-ldkuwcc7 562 11 receptor receptor NN cord-287123-ldkuwcc7 562 12 1 1 CD cord-287123-ldkuwcc7 562 13 Annexin Annexin NNP cord-287123-ldkuwcc7 562 14 a1 a1 NNP cord-287123-ldkuwcc7 562 15 interaction interaction NN cord-287123-ldkuwcc7 562 16 with with IN cord-287123-ldkuwcc7 562 17 the the DT cord-287123-ldkuwcc7 562 18 fpr2 fpr2 NNP cord-287123-ldkuwcc7 562 19 / / SYM cord-287123-ldkuwcc7 562 20 alx alx NNP cord-287123-ldkuwcc7 562 21 receptor receptor NN cord-287123-ldkuwcc7 562 22 : : : cord-287123-ldkuwcc7 563 1 Identification identification NN cord-287123-ldkuwcc7 563 2 of of IN cord-287123-ldkuwcc7 563 3 distinct distinct JJ cord-287123-ldkuwcc7 563 4 domains domain NNS cord-287123-ldkuwcc7 563 5 and and CC cord-287123-ldkuwcc7 563 6 downstream downstream NN cord-287123-ldkuwcc7 563 7 associated associate VBD cord-287123-ldkuwcc7 563 8 signaling signal VBG cord-287123-ldkuwcc7 563 9 Crystal Crystal NNP cord-287123-ldkuwcc7 563 10 structure structure NN cord-287123-ldkuwcc7 563 11 of of IN cord-287123-ldkuwcc7 563 12 rhodopsin rhodopsin NN cord-287123-ldkuwcc7 563 13 : : : cord-287123-ldkuwcc7 564 1 A a DT cord-287123-ldkuwcc7 564 2 g g NN cord-287123-ldkuwcc7 564 3 protein protein NN cord-287123-ldkuwcc7 564 4 - - HYPH cord-287123-ldkuwcc7 564 5 coupled couple VBN cord-287123-ldkuwcc7 564 6 receptor receptor NN cord-287123-ldkuwcc7 564 7 Structures structure NNS cord-287123-ldkuwcc7 564 8 of of IN cord-287123-ldkuwcc7 564 9 the the DT cord-287123-ldkuwcc7 564 10 cxcr4 cxcr4 NN cord-287123-ldkuwcc7 564 11 chemokine chemokine NN cord-287123-ldkuwcc7 564 12 gpcr gpcr NN cord-287123-ldkuwcc7 564 13 with with IN cord-287123-ldkuwcc7 564 14 small small JJ cord-287123-ldkuwcc7 564 15 - - HYPH cord-287123-ldkuwcc7 564 16 molecule molecule NN cord-287123-ldkuwcc7 564 17 and and CC cord-287123-ldkuwcc7 564 18 cyclic cyclic JJ cord-287123-ldkuwcc7 564 19 peptide peptide NN cord-287123-ldkuwcc7 564 20 antagonists antagonist NNS cord-287123-ldkuwcc7 564 21 Non Non NNP cord-287123-ldkuwcc7 564 22 - - JJ cord-287123-ldkuwcc7 564 23 peptide peptide JJ cord-287123-ldkuwcc7 564 24 ligand ligand NN cord-287123-ldkuwcc7 564 25 binding bind VBG cord-287123-ldkuwcc7 564 26 to to IN cord-287123-ldkuwcc7 564 27 the the DT cord-287123-ldkuwcc7 564 28 formyl formyl NNP cord-287123-ldkuwcc7 564 29 peptide peptide NN cord-287123-ldkuwcc7 564 30 receptor receptor NN cord-287123-ldkuwcc7 564 31 fpr2-A fpr2-a CD cord-287123-ldkuwcc7 564 32 comparison comparison NN cord-287123-ldkuwcc7 564 33 to to IN cord-287123-ldkuwcc7 564 34 peptide peptide NN cord-287123-ldkuwcc7 564 35 ligand ligand NN cord-287123-ldkuwcc7 564 36 binding bind VBG cord-287123-ldkuwcc7 564 37 modes mode NNS cord-287123-ldkuwcc7 564 38 Integration integration NN cord-287123-ldkuwcc7 564 39 of of IN cord-287123-ldkuwcc7 564 40 virtual virtual JJ cord-287123-ldkuwcc7 564 41 screening screening NN cord-287123-ldkuwcc7 564 42 with with IN cord-287123-ldkuwcc7 564 43 high high JJ cord-287123-ldkuwcc7 564 44 - - HYPH cord-287123-ldkuwcc7 564 45 throughput throughput NN cord-287123-ldkuwcc7 564 46 flow flow NN cord-287123-ldkuwcc7 564 47 cytometry cytometry NN cord-287123-ldkuwcc7 564 48 to to TO cord-287123-ldkuwcc7 564 49 identify identify VB cord-287123-ldkuwcc7 564 50 novel novel JJ cord-287123-ldkuwcc7 564 51 small small JJ cord-287123-ldkuwcc7 564 52 molecule molecule NN cord-287123-ldkuwcc7 564 53 formylpeptide formylpeptide NN cord-287123-ldkuwcc7 564 54 receptor receptor NN cord-287123-ldkuwcc7 564 55 antagonists antagonist NNS cord-287123-ldkuwcc7 564 56 Pharmacophore Pharmacophore NNP cord-287123-ldkuwcc7 564 57 model model NN cord-287123-ldkuwcc7 564 58 for for IN cord-287123-ldkuwcc7 564 59 bile bile NN cord-287123-ldkuwcc7 564 60 acids acid NNS cord-287123-ldkuwcc7 564 61 recognition recognition NN cord-287123-ldkuwcc7 564 62 by by IN cord-287123-ldkuwcc7 564 63 the the DT cord-287123-ldkuwcc7 564 64 fpr fpr NNP cord-287123-ldkuwcc7 564 65 receptor receptor NN cord-287123-ldkuwcc7 564 66 C C NNP cord-287123-ldkuwcc7 564 67 - - , cord-287123-ldkuwcc7 564 68 and and CC cord-287123-ldkuwcc7 564 69 n n JJ cord-287123-ldkuwcc7 564 70 - - HYPH cord-287123-ldkuwcc7 564 71 terminal terminal JJ cord-287123-ldkuwcc7 564 72 residue residue NN cord-287123-ldkuwcc7 564 73 effect effect NN cord-287123-ldkuwcc7 564 74 on on IN cord-287123-ldkuwcc7 564 75 peptide peptide JJ cord-287123-ldkuwcc7 564 76 derivatives derivative NNS cord-287123-ldkuwcc7 564 77 ' ' POS cord-287123-ldkuwcc7 564 78 antagonism antagonism NN cord-287123-ldkuwcc7 564 79 toward toward IN cord-287123-ldkuwcc7 564 80 the the DT cord-287123-ldkuwcc7 564 81 formyl formyl NNP cord-287123-ldkuwcc7 564 82 - - HYPH cord-287123-ldkuwcc7 564 83 peptide peptide NN cord-287123-ldkuwcc7 564 84 receptor receptor NN cord-287123-ldkuwcc7 564 85 Identification identification NN cord-287123-ldkuwcc7 564 86 of of IN cord-287123-ldkuwcc7 564 87 novel novel NNP cord-287123-ldkuwcc7 564 88 formyl formyl NNP cord-287123-ldkuwcc7 564 89 peptide peptide NN cord-287123-ldkuwcc7 564 90 receptor receptor NN cord-287123-ldkuwcc7 564 91 - - HYPH cord-287123-ldkuwcc7 564 92 like like JJ cord-287123-ldkuwcc7 564 93 1 1 CD cord-287123-ldkuwcc7 564 94 agonists agonist NNS cord-287123-ldkuwcc7 564 95 that that WDT cord-287123-ldkuwcc7 564 96 induce induce VBP cord-287123-ldkuwcc7 564 97 macrophage macrophage NN cord-287123-ldkuwcc7 564 98 tumor tumor NN cord-287123-ldkuwcc7 564 99 necrosis necrosis NN cord-287123-ldkuwcc7 564 100 factor factor NN cord-287123-ldkuwcc7 564 101 alpha alpha NN cord-287123-ldkuwcc7 564 102 production production NN cord-287123-ldkuwcc7 565 1 The the DT cord-287123-ldkuwcc7 565 2 role role NN cord-287123-ldkuwcc7 565 3 of of IN cord-287123-ldkuwcc7 565 4 water water NN cord-287123-ldkuwcc7 565 5 in in IN cord-287123-ldkuwcc7 565 6 activation activation NN cord-287123-ldkuwcc7 565 7 mechanism mechanism NN cord-287123-ldkuwcc7 565 8 of of IN cord-287123-ldkuwcc7 565 9 human human JJ cord-287123-ldkuwcc7 565 10 n n NNP cord-287123-ldkuwcc7 565 11 - - HYPH cord-287123-ldkuwcc7 565 12 formyl formyl NNP cord-287123-ldkuwcc7 565 13 peptide peptide NN cord-287123-ldkuwcc7 565 14 receptor receptor NN cord-287123-ldkuwcc7 565 15 1 1 CD cord-287123-ldkuwcc7 565 16 ( ( -LRB- cord-287123-ldkuwcc7 565 17 fpr1 fpr1 NN cord-287123-ldkuwcc7 565 18 ) ) -RRB- cord-287123-ldkuwcc7 565 19 based base VBN cord-287123-ldkuwcc7 565 20 on on IN cord-287123-ldkuwcc7 565 21 molecular molecular JJ cord-287123-ldkuwcc7 565 22 dynamics dynamic NNS cord-287123-ldkuwcc7 565 23 simulations simulation NNS cord-287123-ldkuwcc7 565 24 Stimulation stimulation NN cord-287123-ldkuwcc7 565 25 of of IN cord-287123-ldkuwcc7 565 26 human human JJ cord-287123-ldkuwcc7 565 27 formyl formyl NNP cord-287123-ldkuwcc7 565 28 peptide peptide NN cord-287123-ldkuwcc7 565 29 receptors receptor NNS cord-287123-ldkuwcc7 565 30 by by IN cord-287123-ldkuwcc7 565 31 calpain calpain NN cord-287123-ldkuwcc7 565 32 inhibitors inhibitor NNS cord-287123-ldkuwcc7 565 33 : : : cord-287123-ldkuwcc7 565 34 Homology homology NN cord-287123-ldkuwcc7 565 35 modeling modeling NN cord-287123-ldkuwcc7 565 36 of of IN cord-287123-ldkuwcc7 565 37 receptors receptor NNS cord-287123-ldkuwcc7 565 38 and and CC cord-287123-ldkuwcc7 565 39 ligand ligand NN cord-287123-ldkuwcc7 565 40 docking docking NN cord-287123-ldkuwcc7 565 41 simulation simulation NN cord-287123-ldkuwcc7 565 42 This this DT cord-287123-ldkuwcc7 565 43 article article NN cord-287123-ldkuwcc7 565 44 is be VBZ cord-287123-ldkuwcc7 565 45 an an DT cord-287123-ldkuwcc7 565 46 open open JJ cord-287123-ldkuwcc7 565 47 access access NN cord-287123-ldkuwcc7 565 48 article article NN cord-287123-ldkuwcc7 565 49 distributed distribute VBN cord-287123-ldkuwcc7 565 50 under under IN cord-287123-ldkuwcc7 565 51 the the DT cord-287123-ldkuwcc7 565 52 terms term NNS cord-287123-ldkuwcc7 565 53 and and CC cord-287123-ldkuwcc7 565 54 conditions condition NNS cord-287123-ldkuwcc7 565 55 of of IN cord-287123-ldkuwcc7 565 56 the the DT cord-287123-ldkuwcc7 565 57 Creative Creative NNP cord-287123-ldkuwcc7 565 58 Commons Commons NNP cord-287123-ldkuwcc7 565 59 Attribution Attribution NNP cord-287123-ldkuwcc7 565 60 ( ( -LRB- cord-287123-ldkuwcc7 565 61 CC CC NNP cord-287123-ldkuwcc7 565 62 BY by IN cord-287123-ldkuwcc7 565 63 ) ) -RRB- cord-287123-ldkuwcc7 565 64 license license NN