id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332003-67e9fchy	Boisguérin, Prisca	Delivery of therapeutic oligonucleotides with cell penetrating peptides()	2015-06-29		.txt	text/plain	13067	636	42	Although challenged later on as detailed in Section 7, this mechanism and the possibility to use such so called cell-penetrating peptides (CPPs) as non-viral delivery vectors for biomolecules, fostered a very large interest. Since the chemical conjugation and purification of negatively charged ONs with the most popular cationic CPPs has turned out to be difficult, most applications have concerned chargeneutral ON analogues such as Peptide Nucleic Acids (PNAs) and PMO (see Section 3). Unexpectedly, in a well-characterized HeLa 705 cell assay with a positive read-out ( Fig. 1) , splicing redirection using PNA or PMO oligomers conjugated to various standard CPPs (Tat, Penetratin or oligo-arginines) was not achieved in our research groups [57] . This led to the development of several arginine-rich peptides as PMO conjugates for use in muscle cells and in vivo mouse models of DMD as outlined in Section 4.	./cache/cord-332003-67e9fchy.txt	./txt/cord-332003-67e9fchy.txt