id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321417-6code4oh	Benincasa, Monica	In vitro and in vivo antimicrobial activity of two α-helical cathelicidin peptides and of their synthetic analogs	2003-12-20		.txt	text/plain	4563	214	47	The parent peptides and mBMAP-28 analog protected mice from lethal i.p. infections in an acute peritonitis model at peptide doses significantly lower than those toxic to the animals, suggesting a satisfactory therapeutic index. Specifically, we analysed the in vitro activity of BMAP-27 and -28 and of their analogs against a wide panel of Gramnegative and -positive clinical isolates, also including many antibiotic-resistant strains, and against the human herpes simplex virus type 1 (HSV-1). The in vitro antibacterial activity of purified BMAP peptides and of their analogs was determined as the minimum inhibitory concentration (MIC) by a microdilution susceptibility test in 96-well microtiter plates, according to the guidelines of the National Committee for Clinical Laboratory Standards (NCCLS). The potential of BMAPs to protect mice from a bacterial challenge was tested in a model of acute peritonitis induced by i.p. injection of a lethal dose of P.	./cache/cord-321417-6code4oh.txt	./txt/cord-321417-6code4oh.txt