id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316792-89f8g0m8	Herzig, Volker	Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery	2020-06-12		.txt	text/plain	12747	631	42	Over the course of evolution, toxins with exceptional specificity and high potency for their intended molecular targets have prevailed, making venoms an invaluable and almost inexhaustible source of bioactive molecules, some of which have found use as pharmacological tools, human therapeutics, and bioinsecticides. Current biomedically-focused research on venoms is directed towards their use in delineating the physiological role of toxin molecular targets such as ion channels and receptors, studying or treating human diseases, targeting vectors of human diseases, and treating microbial and parasitic infections. Since many venoms and toxins exert these biological effects through actions on cell membranes, receptors and ion channels, high-throughput techniques assessing changes in cellular signalling have proven particularly insightful. Spider-venom peptides have been crucial for uncovering the key role of ASICs in stroke-induced brain damage, and validating these channels as a target for neuroprotective drugs [134] [135] [136] [137] .	./cache/cord-316792-89f8g0m8.txt	./txt/cord-316792-89f8g0m8.txt