id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285443-9y2kkmby	Pessi, Antonello	Cholesterol‐conjugated peptide antivirals: a path to a rapid response to emerging viral diseases	2014-10-20		.txt	text/plain	5036	255	41	The combination of bioinformatic lead identification and potency/pharmacokinetics improvement provided by cholesterol conjugation may form the basis for a rapid response strategy, where development of an emergency cholesterol‐conjugated therapeutic would immediately follow the availability of the genetic information of a new enveloped virus. For example, although the entry of herpes viruses (featuring a class III fusion protein) is a complex process, not yet fully clarified, in which multiple glycoproteins are involved, several laboratories have reported that peptides derived from the HR regions of gB and gH of herpes simplex virus type 1, bovine herpes virus type 1, and human cytomegalovirus are able to inhibit infection [103] . Given the ubiquitous importance of cholesterol-rich lipid rafts in viral fusion, it is expected that cholesterol conjugation may enhance the antiviral potency also for peptides derived from class II and III fusion proteins. Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein	./cache/cord-285443-9y2kkmby.txt	./txt/cord-285443-9y2kkmby.txt