id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103837-iuvigqdx	Knierman, Michael D.	The Human Leukocyte Antigen Class II Immunopeptidome of SARS-CoV-2 Spike Glycoprotein	2020-11-13		.txt	text/plain	8578	439	54	Mass spectrometry is used to identify 526 unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from a panel of healthy donors selected to represent a majority of allele usage from this highly polymorphic molecule. The ability to automate and miniaturize the MAPPs assay enables facile identification of 1000's of naturally processed and displayed HLA-II peptides from human DCs. Using this approach, we were able J o u r n a l P r e -p r o o f to determine the precise regions and sequences of peptides from SARS-CoV-2 spike glycoprotein ECD derived from a panel of healthy subjects presented for immune surveillance by T-cells. We observed a total of 526 unique peptide sequences contained within 73 clusters distributed across each segment of the SARS-CoV-2 spike glycoprotein ECD presented by human DCs (Figure 2 and Supplemental Table S2 ).	./cache/cord-103837-iuvigqdx.txt	./txt/cord-103837-iuvigqdx.txt