id sid tid token lemma pos cord-305859-vt8vwo3y 1 1 key key JJ cord-305859-vt8vwo3y 1 2 : : : cord-305859-vt8vwo3y 1 3 cord-305859-vt8vwo3y cord-305859-vt8vwo3y , cord-305859-vt8vwo3y 1 4 authors author NNS cord-305859-vt8vwo3y 1 5 : : : cord-305859-vt8vwo3y 1 6 Jung Jung NNP cord-305859-vt8vwo3y 1 7 , , , cord-305859-vt8vwo3y 1 8 Kwonil Kwonil NNP cord-305859-vt8vwo3y 1 9 ; ; : cord-305859-vt8vwo3y 1 10 Hu Hu NNP cord-305859-vt8vwo3y 1 11 , , , cord-305859-vt8vwo3y 1 12 Hui Hui NNP cord-305859-vt8vwo3y 1 13 ; ; : cord-305859-vt8vwo3y 1 14 Saif Saif NNP cord-305859-vt8vwo3y 1 15 , , , cord-305859-vt8vwo3y 1 16 Linda Linda NNP cord-305859-vt8vwo3y 1 17 J. J. NNP cord-305859-vt8vwo3y 2 1 title title NN cord-305859-vt8vwo3y 2 2 : : : cord-305859-vt8vwo3y 3 1 Calves calf NNS cord-305859-vt8vwo3y 3 2 are be VBP cord-305859-vt8vwo3y 3 3 susceptible susceptible JJ cord-305859-vt8vwo3y 3 4 to to IN cord-305859-vt8vwo3y 3 5 infection infection NN cord-305859-vt8vwo3y 3 6 with with IN cord-305859-vt8vwo3y 3 7 the the DT cord-305859-vt8vwo3y 3 8 newly newly RB cord-305859-vt8vwo3y 3 9 emerged emerge VBN cord-305859-vt8vwo3y 3 10 porcine porcine JJ cord-305859-vt8vwo3y 3 11 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 3 12 , , , cord-305859-vt8vwo3y 3 13 but but CC cord-305859-vt8vwo3y 3 14 not not RB cord-305859-vt8vwo3y 3 15 with with IN cord-305859-vt8vwo3y 3 16 the the DT cord-305859-vt8vwo3y 3 17 swine swine NN cord-305859-vt8vwo3y 3 18 enteric enteric JJ cord-305859-vt8vwo3y 3 19 alphacoronavirus alphacoronavirus NN cord-305859-vt8vwo3y 3 20 , , , cord-305859-vt8vwo3y 3 21 porcine porcine JJ cord-305859-vt8vwo3y 3 22 epidemic epidemic NN cord-305859-vt8vwo3y 3 23 diarrhea diarrhea NN cord-305859-vt8vwo3y 3 24 virus virus NN cord-305859-vt8vwo3y 3 25 date date NN cord-305859-vt8vwo3y 3 26 : : : cord-305859-vt8vwo3y 3 27 2017 2017 CD cord-305859-vt8vwo3y 3 28 - - HYPH cord-305859-vt8vwo3y 3 29 04 04 CD cord-305859-vt8vwo3y 3 30 - - HYPH cord-305859-vt8vwo3y 3 31 03 03 CD cord-305859-vt8vwo3y 3 32 journal journal NN cord-305859-vt8vwo3y 3 33 : : : cord-305859-vt8vwo3y 4 1 Arch Arch NNP cord-305859-vt8vwo3y 4 2 Virol Virol NNP cord-305859-vt8vwo3y 5 1 DOI DOI NNP cord-305859-vt8vwo3y 5 2 : : : cord-305859-vt8vwo3y 6 1 10.1007 10.1007 CD cord-305859-vt8vwo3y 6 2 / / SYM cord-305859-vt8vwo3y 6 3 s00705 s00705 CD cord-305859-vt8vwo3y 6 4 - - HYPH cord-305859-vt8vwo3y 6 5 017 017 CD cord-305859-vt8vwo3y 6 6 - - HYPH cord-305859-vt8vwo3y 6 7 3351-z 3351-z NNP cord-305859-vt8vwo3y 6 8 sha sha NNP cord-305859-vt8vwo3y 6 9 : : : cord-305859-vt8vwo3y 6 10 1626ffb1fa8e2dee8b77761c0cadcd5dca957114 1626ffb1fa8e2dee8b77761c0cadcd5dca957114 CD cord-305859-vt8vwo3y 6 11 doc_id doc_id CD cord-305859-vt8vwo3y 6 12 : : : cord-305859-vt8vwo3y 6 13 305859 305859 CD cord-305859-vt8vwo3y 6 14 cord_uid cord_uid NNS cord-305859-vt8vwo3y 6 15 : : : cord-305859-vt8vwo3y 6 16 vt8vwo3y vt8vwo3y NNP cord-305859-vt8vwo3y 6 17 Fecal fecal JJ cord-305859-vt8vwo3y 6 18 virus virus NN cord-305859-vt8vwo3y 6 19 shedding shed VBG cord-305859-vt8vwo3y 6 20 , , , cord-305859-vt8vwo3y 6 21 seroconversion seroconversion NN cord-305859-vt8vwo3y 6 22 and and CC cord-305859-vt8vwo3y 6 23 histopathology histopathology NN cord-305859-vt8vwo3y 6 24 were be VBD cord-305859-vt8vwo3y 6 25 evaluated evaluate VBN cord-305859-vt8vwo3y 6 26 in in IN cord-305859-vt8vwo3y 6 27 3 3 CD cord-305859-vt8vwo3y 6 28 - - HYPH cord-305859-vt8vwo3y 6 29 7-year 7-year JJ cord-305859-vt8vwo3y 6 30 - - HYPH cord-305859-vt8vwo3y 6 31 old old JJ cord-305859-vt8vwo3y 6 32 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 6 33 calves calf NNS cord-305859-vt8vwo3y 6 34 orally orally RB cord-305859-vt8vwo3y 6 35 inoculated inoculate VBD cord-305859-vt8vwo3y 6 36 with with IN cord-305859-vt8vwo3y 6 37 porcine porcine JJ cord-305859-vt8vwo3y 6 38 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 6 39 ( ( -LRB- cord-305859-vt8vwo3y 6 40 PDCoV PDCoV NNP cord-305859-vt8vwo3y 6 41 ) ) -RRB- cord-305859-vt8vwo3y 6 42 ( ( -LRB- cord-305859-vt8vwo3y 6 43 9.0 9.0 CD cord-305859-vt8vwo3y 6 44 - - SYM cord-305859-vt8vwo3y 6 45 9.6 9.6 CD cord-305859-vt8vwo3y 6 46 log(10 log(10 NN cord-305859-vt8vwo3y 6 47 ) ) -RRB- cord-305859-vt8vwo3y 7 1 genomic genomic JJ cord-305859-vt8vwo3y 7 2 equivalents equivalent NNS cord-305859-vt8vwo3y 7 3 [ [ -LRB- cord-305859-vt8vwo3y 7 4 GE GE NNP cord-305859-vt8vwo3y 7 5 ] ] -RRB- cord-305859-vt8vwo3y 7 6 of of IN cord-305859-vt8vwo3y 7 7 OH OH NNP cord-305859-vt8vwo3y 7 8 - - HYPH cord-305859-vt8vwo3y 7 9 FD22-P5 fd22-p5 NN cord-305859-vt8vwo3y 7 10 ; ; : cord-305859-vt8vwo3y 7 11 n=4 n=4 JJ cord-305859-vt8vwo3y 7 12 ) ) -RRB- cord-305859-vt8vwo3y 7 13 or or CC cord-305859-vt8vwo3y 7 14 porcine porcine JJ cord-305859-vt8vwo3y 7 15 epidemic epidemic NN cord-305859-vt8vwo3y 7 16 diarrhea diarrhea NN cord-305859-vt8vwo3y 7 17 virus virus NN cord-305859-vt8vwo3y 7 18 ( ( -LRB- cord-305859-vt8vwo3y 7 19 PEDV PEDV NNP cord-305859-vt8vwo3y 7 20 ) ) -RRB- cord-305859-vt8vwo3y 8 1 ( ( -LRB- cord-305859-vt8vwo3y 8 2 10.2 10.2 CD cord-305859-vt8vwo3y 8 3 - - SYM cord-305859-vt8vwo3y 8 4 12.5 12.5 CD cord-305859-vt8vwo3y 8 5 log(10 log(10 NNP cord-305859-vt8vwo3y 8 6 ) ) -RRB- cord-305859-vt8vwo3y 8 7 GE GE NNP cord-305859-vt8vwo3y 8 8 of of IN cord-305859-vt8vwo3y 8 9 PC21A PC21A NNP cord-305859-vt8vwo3y 8 10 ; ; : cord-305859-vt8vwo3y 8 11 n=3 n=3 NN cord-305859-vt8vwo3y 8 12 ) ) -RRB- cord-305859-vt8vwo3y 8 13 . . . cord-305859-vt8vwo3y 9 1 In in IN cord-305859-vt8vwo3y 9 2 PDCoV pdcov RB cord-305859-vt8vwo3y 9 3 - - HYPH cord-305859-vt8vwo3y 9 4 inoculated inoculate VBN cord-305859-vt8vwo3y 9 5 calves calf NNS cord-305859-vt8vwo3y 9 6 , , , cord-305859-vt8vwo3y 9 7 an an DT cord-305859-vt8vwo3y 9 8 acute acute NN cord-305859-vt8vwo3y 9 9 but but CC cord-305859-vt8vwo3y 9 10 persisting persist VBG cord-305859-vt8vwo3y 9 11 fecal fecal JJ cord-305859-vt8vwo3y 9 12 viral viral JJ cord-305859-vt8vwo3y 9 13 RNA RNA NNP cord-305859-vt8vwo3y 9 14 shedding shed VBG cord-305859-vt8vwo3y 9 15 and and CC cord-305859-vt8vwo3y 9 16 PDCoV pdcov RB cord-305859-vt8vwo3y 9 17 - - HYPH cord-305859-vt8vwo3y 9 18 specific specific JJ cord-305859-vt8vwo3y 9 19 serum serum NN cord-305859-vt8vwo3y 9 20 IgG igg NN cord-305859-vt8vwo3y 9 21 antibody antibody NN cord-305859-vt8vwo3y 9 22 responses response NNS cord-305859-vt8vwo3y 9 23 were be VBD cord-305859-vt8vwo3y 9 24 observed observe VBN cord-305859-vt8vwo3y 9 25 , , , cord-305859-vt8vwo3y 9 26 but but CC cord-305859-vt8vwo3y 9 27 without without IN cord-305859-vt8vwo3y 9 28 lesions lesion NNS cord-305859-vt8vwo3y 9 29 or or CC cord-305859-vt8vwo3y 9 30 clinical clinical JJ cord-305859-vt8vwo3y 9 31 disease disease NN cord-305859-vt8vwo3y 9 32 . . . cord-305859-vt8vwo3y 10 1 However however RB cord-305859-vt8vwo3y 10 2 , , , cord-305859-vt8vwo3y 10 3 no no DT cord-305859-vt8vwo3y 10 4 fecal fecal JJ cord-305859-vt8vwo3y 10 5 shedding shedding NN cord-305859-vt8vwo3y 10 6 , , , cord-305859-vt8vwo3y 10 7 seroconversion seroconversion NN cord-305859-vt8vwo3y 10 8 , , , cord-305859-vt8vwo3y 10 9 histological histological JJ cord-305859-vt8vwo3y 10 10 lesions lesion NNS cord-305859-vt8vwo3y 10 11 , , , cord-305859-vt8vwo3y 10 12 and and CC cord-305859-vt8vwo3y 10 13 clinical clinical JJ cord-305859-vt8vwo3y 10 14 disease disease NN cord-305859-vt8vwo3y 10 15 were be VBD cord-305859-vt8vwo3y 10 16 detected detect VBN cord-305859-vt8vwo3y 10 17 in in IN cord-305859-vt8vwo3y 10 18 PEDV PEDV NNP cord-305859-vt8vwo3y 10 19 - - HYPH cord-305859-vt8vwo3y 10 20 inoculated inoculate VBN cord-305859-vt8vwo3y 10 21 calves calf NNS cord-305859-vt8vwo3y 10 22 . . . cord-305859-vt8vwo3y 11 1 Our -PRON- PRP$ cord-305859-vt8vwo3y 11 2 data datum NNS cord-305859-vt8vwo3y 11 3 indicate indicate VBP cord-305859-vt8vwo3y 11 4 that that IN cord-305859-vt8vwo3y 11 5 calves calf NNS cord-305859-vt8vwo3y 11 6 are be VBP cord-305859-vt8vwo3y 11 7 susceptible susceptible JJ cord-305859-vt8vwo3y 11 8 to to IN cord-305859-vt8vwo3y 11 9 infection infection NN cord-305859-vt8vwo3y 11 10 by by IN cord-305859-vt8vwo3y 11 11 the the DT cord-305859-vt8vwo3y 11 12 newly newly RB cord-305859-vt8vwo3y 11 13 emerged emerge VBN cord-305859-vt8vwo3y 11 14 PDCoV pdcov DT cord-305859-vt8vwo3y 11 15 , , , cord-305859-vt8vwo3y 11 16 but but CC cord-305859-vt8vwo3y 11 17 not not RB cord-305859-vt8vwo3y 11 18 by by IN cord-305859-vt8vwo3y 11 19 the the DT cord-305859-vt8vwo3y 11 20 swine swine NN cord-305859-vt8vwo3y 11 21 coronavirus coronavirus NN cord-305859-vt8vwo3y 11 22 , , , cord-305859-vt8vwo3y 11 23 PEDV PEDV NNP cord-305859-vt8vwo3y 11 24 . . . cord-305859-vt8vwo3y 12 1 Coronaviruses Coronaviruses NNP cord-305859-vt8vwo3y 12 2 ( ( -LRB- cord-305859-vt8vwo3y 12 3 CoVs CoVs NNP cord-305859-vt8vwo3y 12 4 ) ) -RRB- cord-305859-vt8vwo3y 12 5 are be VBP cord-305859-vt8vwo3y 12 6 enveloped envelop VBN cord-305859-vt8vwo3y 12 7 , , , cord-305859-vt8vwo3y 12 8 single single RB cord-305859-vt8vwo3y 12 9 - - HYPH cord-305859-vt8vwo3y 12 10 stranded strand VBN cord-305859-vt8vwo3y 12 11 RNA RNA NNP cord-305859-vt8vwo3y 12 12 viruses virus NNS cord-305859-vt8vwo3y 12 13 of of IN cord-305859-vt8vwo3y 12 14 positive positive JJ cord-305859-vt8vwo3y 12 15 - - HYPH cord-305859-vt8vwo3y 12 16 sense sense NN cord-305859-vt8vwo3y 12 17 polarity polarity NN cord-305859-vt8vwo3y 12 18 . . . cord-305859-vt8vwo3y 13 1 Their -PRON- PRP$ cord-305859-vt8vwo3y 13 2 genomes genome NNS cord-305859-vt8vwo3y 13 3 range range VBP cord-305859-vt8vwo3y 13 4 from from IN cord-305859-vt8vwo3y 13 5 approximately approximately RB cord-305859-vt8vwo3y 13 6 26 26 CD cord-305859-vt8vwo3y 13 7 to to TO cord-305859-vt8vwo3y 13 8 32 32 CD cord-305859-vt8vwo3y 13 9 kb kb NNS cord-305859-vt8vwo3y 13 10 in in IN cord-305859-vt8vwo3y 13 11 size size NN cord-305859-vt8vwo3y 13 12 [ [ -LRB- cord-305859-vt8vwo3y 13 13 16 16 CD cord-305859-vt8vwo3y 13 14 ] ] -RRB- cord-305859-vt8vwo3y 13 15 . . . cord-305859-vt8vwo3y 14 1 The the DT cord-305859-vt8vwo3y 14 2 family family NN cord-305859-vt8vwo3y 14 3 Coronaviridae Coronaviridae NNP cord-305859-vt8vwo3y 14 4 of of IN cord-305859-vt8vwo3y 14 5 the the DT cord-305859-vt8vwo3y 14 6 order order NN cord-305859-vt8vwo3y 14 7 Nidovirales Nidovirales NNP cord-305859-vt8vwo3y 14 8 is be VBZ cord-305859-vt8vwo3y 14 9 divided divide VBN cord-305859-vt8vwo3y 14 10 into into IN cord-305859-vt8vwo3y 14 11 the the DT cord-305859-vt8vwo3y 14 12 four four CD cord-305859-vt8vwo3y 14 13 genera genus NNS cord-305859-vt8vwo3y 14 14 : : : cord-305859-vt8vwo3y 14 15 Alphacoronavirus Alphacoronavirus NNP cord-305859-vt8vwo3y 14 16 , , , cord-305859-vt8vwo3y 14 17 Betacoronavirus Betacoronavirus NNP cord-305859-vt8vwo3y 14 18 , , , cord-305859-vt8vwo3y 14 19 Gammacoronavirus Gammacoronavirus NNP cord-305859-vt8vwo3y 14 20 , , , cord-305859-vt8vwo3y 14 21 and and CC cord-305859-vt8vwo3y 14 22 Deltacoronavirus Deltacoronavirus NNP cord-305859-vt8vwo3y 14 23 . . . cord-305859-vt8vwo3y 15 1 Bats bat NNS cord-305859-vt8vwo3y 15 2 are be VBP cord-305859-vt8vwo3y 15 3 the the DT cord-305859-vt8vwo3y 15 4 projected project VBN cord-305859-vt8vwo3y 15 5 host host NN cord-305859-vt8vwo3y 15 6 reservoir reservoir NN cord-305859-vt8vwo3y 15 7 for for IN cord-305859-vt8vwo3y 15 8 alphacoronaviruses alphacoronaviruse NNS cord-305859-vt8vwo3y 15 9 and and CC cord-305859-vt8vwo3y 15 10 betacoronaviruses betacoronaviruses NNP cord-305859-vt8vwo3y 15 11 , , , cord-305859-vt8vwo3y 15 12 while while IN cord-305859-vt8vwo3y 15 13 birds bird NNS cord-305859-vt8vwo3y 15 14 are be VBP cord-305859-vt8vwo3y 15 15 thought think VBN cord-305859-vt8vwo3y 15 16 to to TO cord-305859-vt8vwo3y 15 17 be be VB cord-305859-vt8vwo3y 15 18 the the DT cord-305859-vt8vwo3y 15 19 host host NN cord-305859-vt8vwo3y 15 20 for for IN cord-305859-vt8vwo3y 15 21 gammacoronaviruses gammacoronaviruses NNP cord-305859-vt8vwo3y 15 22 and and CC cord-305859-vt8vwo3y 15 23 deltacoronaviruses deltacoronaviruses NNPS cord-305859-vt8vwo3y 15 24 [ [ -LRB- cord-305859-vt8vwo3y 15 25 18 18 CD cord-305859-vt8vwo3y 15 26 ] ] -RRB- cord-305859-vt8vwo3y 15 27 . . . cord-305859-vt8vwo3y 16 1 The the DT cord-305859-vt8vwo3y 16 2 two two CD cord-305859-vt8vwo3y 16 3 betacoronaviruses betacoronaviruse NNS cord-305859-vt8vwo3y 16 4 , , , cord-305859-vt8vwo3y 16 5 severe severe JJ cord-305859-vt8vwo3y 16 6 acute acute JJ cord-305859-vt8vwo3y 16 7 respiratory respiratory JJ cord-305859-vt8vwo3y 16 8 syndrome syndrome NN cord-305859-vt8vwo3y 16 9 CoV cov NN cord-305859-vt8vwo3y 16 10 ( ( -LRB- cord-305859-vt8vwo3y 16 11 SARS SARS NNP cord-305859-vt8vwo3y 16 12 - - HYPH cord-305859-vt8vwo3y 16 13 CoV CoV NNP cord-305859-vt8vwo3y 16 14 ) ) -RRB- cord-305859-vt8vwo3y 16 15 and and CC cord-305859-vt8vwo3y 16 16 Middle Middle NNP cord-305859-vt8vwo3y 16 17 East East NNP cord-305859-vt8vwo3y 16 18 respiratory respiratory JJ cord-305859-vt8vwo3y 16 19 syndrome syndrome NN cord-305859-vt8vwo3y 16 20 CoV cov NN cord-305859-vt8vwo3y 16 21 ( ( -LRB- cord-305859-vt8vwo3y 16 22 MERS MERS NNP cord-305859-vt8vwo3y 16 23 - - HYPH cord-305859-vt8vwo3y 16 24 CoV CoV NNP cord-305859-vt8vwo3y 16 25 ) ) -RRB- cord-305859-vt8vwo3y 16 26 , , , cord-305859-vt8vwo3y 16 27 were be VBD cord-305859-vt8vwo3y 16 28 transmitted transmit VBN cord-305859-vt8vwo3y 16 29 by by IN cord-305859-vt8vwo3y 16 30 civet civet NN cord-305859-vt8vwo3y 16 31 cats cat NNS cord-305859-vt8vwo3y 16 32 and and CC cord-305859-vt8vwo3y 16 33 camels camel NNS cord-305859-vt8vwo3y 16 34 , , , cord-305859-vt8vwo3y 16 35 respectively respectively RB cord-305859-vt8vwo3y 16 36 , , , cord-305859-vt8vwo3y 16 37 to to IN cord-305859-vt8vwo3y 16 38 humans human NNS cord-305859-vt8vwo3y 16 39 , , , cord-305859-vt8vwo3y 16 40 but but CC cord-305859-vt8vwo3y 16 41 they -PRON- PRP cord-305859-vt8vwo3y 16 42 have have VBP cord-305859-vt8vwo3y 16 43 shown show VBN cord-305859-vt8vwo3y 16 44 limited limited JJ cord-305859-vt8vwo3y 16 45 capacity capacity NN cord-305859-vt8vwo3y 16 46 for for IN cord-305859-vt8vwo3y 16 47 adaptation adaptation NN cord-305859-vt8vwo3y 16 48 to to IN cord-305859-vt8vwo3y 16 49 humans human NNS cord-305859-vt8vwo3y 16 50 [ [ -LRB- cord-305859-vt8vwo3y 16 51 16 16 CD cord-305859-vt8vwo3y 16 52 ] ] -RRB- cord-305859-vt8vwo3y 16 53 . . . cord-305859-vt8vwo3y 17 1 Some some DT cord-305859-vt8vwo3y 17 2 CoVs covs NN cord-305859-vt8vwo3y 17 3 can can MD cord-305859-vt8vwo3y 17 4 be be VB cord-305859-vt8vwo3y 17 5 transmitted transmit VBN cord-305859-vt8vwo3y 17 6 to to IN cord-305859-vt8vwo3y 17 7 different different JJ cord-305859-vt8vwo3y 17 8 animal animal NN cord-305859-vt8vwo3y 17 9 species specie NNS cord-305859-vt8vwo3y 17 10 , , , cord-305859-vt8vwo3y 17 11 and and CC cord-305859-vt8vwo3y 17 12 subsequently subsequently RB cord-305859-vt8vwo3y 17 13 adapt adapt VB cord-305859-vt8vwo3y 17 14 to to TO cord-305859-vt8vwo3y 17 15 and and CC cord-305859-vt8vwo3y 17 16 be be VB cord-305859-vt8vwo3y 17 17 maintained maintain VBN cord-305859-vt8vwo3y 17 18 in in IN cord-305859-vt8vwo3y 17 19 the the DT cord-305859-vt8vwo3y 17 20 new new JJ cord-305859-vt8vwo3y 17 21 host host NN cord-305859-vt8vwo3y 17 22 , , , cord-305859-vt8vwo3y 17 23 because because IN cord-305859-vt8vwo3y 17 24 they -PRON- PRP cord-305859-vt8vwo3y 17 25 can can MD cord-305859-vt8vwo3y 17 26 exploit exploit VB cord-305859-vt8vwo3y 17 27 or or CC cord-305859-vt8vwo3y 17 28 share share VB cord-305859-vt8vwo3y 17 29 a a DT cord-305859-vt8vwo3y 17 30 variety variety NN cord-305859-vt8vwo3y 17 31 of of IN cord-305859-vt8vwo3y 17 32 host host NN cord-305859-vt8vwo3y 17 33 cell cell NN cord-305859-vt8vwo3y 17 34 surface surface NN cord-305859-vt8vwo3y 17 35 molecules molecule NNS cord-305859-vt8vwo3y 17 36 or or CC cord-305859-vt8vwo3y 17 37 other other JJ cord-305859-vt8vwo3y 17 38 undefined undefined JJ cord-305859-vt8vwo3y 17 39 factors factor NNS cord-305859-vt8vwo3y 17 40 [ [ -LRB- cord-305859-vt8vwo3y 17 41 16 16 CD cord-305859-vt8vwo3y 17 42 ] ] -RRB- cord-305859-vt8vwo3y 17 43 . . . cord-305859-vt8vwo3y 18 1 The the DT cord-305859-vt8vwo3y 18 2 species specie NNS cord-305859-vt8vwo3y 18 3 Porcine porcine JJ cord-305859-vt8vwo3y 18 4 epidemic epidemic NN cord-305859-vt8vwo3y 18 5 diarrhea diarrhea NN cord-305859-vt8vwo3y 18 6 virus virus NN cord-305859-vt8vwo3y 18 7 belongs belong VBZ cord-305859-vt8vwo3y 18 8 to to IN cord-305859-vt8vwo3y 18 9 the the DT cord-305859-vt8vwo3y 18 10 genus genus NN cord-305859-vt8vwo3y 18 11 Alphacoronavirus Alphacoronavirus NNP cord-305859-vt8vwo3y 18 12 . . . cord-305859-vt8vwo3y 19 1 Porcine porcine JJ cord-305859-vt8vwo3y 19 2 epidemic epidemic NN cord-305859-vt8vwo3y 19 3 diarrhea diarrhea NN cord-305859-vt8vwo3y 19 4 virus virus NN cord-305859-vt8vwo3y 19 5 ( ( -LRB- cord-305859-vt8vwo3y 19 6 PEDV PEDV NNP cord-305859-vt8vwo3y 19 7 ) ) -RRB- cord-305859-vt8vwo3y 19 8 causes cause VBZ cord-305859-vt8vwo3y 19 9 acute acute JJ cord-305859-vt8vwo3y 19 10 diarrhea diarrhea NN cord-305859-vt8vwo3y 19 11 , , , cord-305859-vt8vwo3y 19 12 dehydration dehydration NN cord-305859-vt8vwo3y 19 13 and and CC cord-305859-vt8vwo3y 19 14 high high JJ cord-305859-vt8vwo3y 19 15 mortality mortality NN cord-305859-vt8vwo3y 19 16 in in IN cord-305859-vt8vwo3y 19 17 neonatal neonatal JJ cord-305859-vt8vwo3y 19 18 piglets piglet NNS cord-305859-vt8vwo3y 19 19 [ [ -LRB- cord-305859-vt8vwo3y 19 20 9 9 CD cord-305859-vt8vwo3y 19 21 ] ] -RRB- cord-305859-vt8vwo3y 19 22 . . . cord-305859-vt8vwo3y 20 1 For for IN cord-305859-vt8vwo3y 20 2 the the DT cord-305859-vt8vwo3y 20 3 last last JJ cord-305859-vt8vwo3y 20 4 four four CD cord-305859-vt8vwo3y 20 5 decades decade NNS cord-305859-vt8vwo3y 20 6 , , , cord-305859-vt8vwo3y 20 7 since since IN cord-305859-vt8vwo3y 20 8 the the DT cord-305859-vt8vwo3y 20 9 first first JJ cord-305859-vt8vwo3y 20 10 appearance appearance NN cord-305859-vt8vwo3y 20 11 of of IN cord-305859-vt8vwo3y 20 12 PEDV PEDV NNP cord-305859-vt8vwo3y 20 13 in in IN cord-305859-vt8vwo3y 20 14 1977 1977 CD cord-305859-vt8vwo3y 20 15 , , , cord-305859-vt8vwo3y 20 16 PEDV PEDV NNP cord-305859-vt8vwo3y 20 17 infection infection NN cord-305859-vt8vwo3y 20 18 has have VBZ cord-305859-vt8vwo3y 20 19 resulted result VBN cord-305859-vt8vwo3y 20 20 in in IN cord-305859-vt8vwo3y 20 21 significant significant JJ cord-305859-vt8vwo3y 20 22 economic economic JJ cord-305859-vt8vwo3y 20 23 losses loss NNS cord-305859-vt8vwo3y 20 24 in in IN cord-305859-vt8vwo3y 20 25 the the DT cord-305859-vt8vwo3y 20 26 European european JJ cord-305859-vt8vwo3y 20 27 , , , cord-305859-vt8vwo3y 20 28 Asian asian JJ cord-305859-vt8vwo3y 20 29 and and CC cord-305859-vt8vwo3y 20 30 US US NNP cord-305859-vt8vwo3y 20 31 swine swine NN cord-305859-vt8vwo3y 20 32 industries industry NNS cord-305859-vt8vwo3y 20 33 . . . cord-305859-vt8vwo3y 21 1 PEDV PEDV NNP cord-305859-vt8vwo3y 21 2 has have VBZ cord-305859-vt8vwo3y 21 3 been be VBN cord-305859-vt8vwo3y 21 4 found find VBN cord-305859-vt8vwo3y 21 5 only only RB cord-305859-vt8vwo3y 21 6 within within IN cord-305859-vt8vwo3y 21 7 the the DT cord-305859-vt8vwo3y 21 8 pig pig NN cord-305859-vt8vwo3y 21 9 population population NN cord-305859-vt8vwo3y 21 10 , , , cord-305859-vt8vwo3y 21 11 indicating indicate VBG cord-305859-vt8vwo3y 21 12 that that IN cord-305859-vt8vwo3y 21 13 the the DT cord-305859-vt8vwo3y 21 14 virus virus NN cord-305859-vt8vwo3y 21 15 might may MD cord-305859-vt8vwo3y 21 16 have have VB cord-305859-vt8vwo3y 21 17 adapted adapt VBN cord-305859-vt8vwo3y 21 18 only only RB cord-305859-vt8vwo3y 21 19 to to IN cord-305859-vt8vwo3y 21 20 pigs pig NNS cord-305859-vt8vwo3y 21 21 [ [ -LRB- cord-305859-vt8vwo3y 21 22 9 9 CD cord-305859-vt8vwo3y 21 23 ] ] -RRB- cord-305859-vt8vwo3y 21 24 . . . cord-305859-vt8vwo3y 22 1 The the DT cord-305859-vt8vwo3y 22 2 species specie NNS cord-305859-vt8vwo3y 22 3 Porcine Porcine NNP cord-305859-vt8vwo3y 22 4 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 22 5 belongs belong VBZ cord-305859-vt8vwo3y 22 6 to to IN cord-305859-vt8vwo3y 22 7 the the DT cord-305859-vt8vwo3y 22 8 genus genus NN cord-305859-vt8vwo3y 22 9 Deltacoronavirus Deltacoronavirus NNP cord-305859-vt8vwo3y 22 10 . . . cord-305859-vt8vwo3y 23 1 Porcine porcine JJ cord-305859-vt8vwo3y 23 2 deltavoronavirus deltavoronavirus NN cord-305859-vt8vwo3y 23 3 ( ( -LRB- cord-305859-vt8vwo3y 23 4 PDCoV PDCoV NNP cord-305859-vt8vwo3y 23 5 ) ) -RRB- cord-305859-vt8vwo3y 23 6 is be VBZ cord-305859-vt8vwo3y 23 7 a a DT cord-305859-vt8vwo3y 23 8 novel novel JJ cord-305859-vt8vwo3y 23 9 enteropathogenic enteropathogenic NNP cord-305859-vt8vwo3y 23 10 CoV cov NN cord-305859-vt8vwo3y 23 11 infecting infect VBG cord-305859-vt8vwo3y 23 12 pigs pig NNS cord-305859-vt8vwo3y 23 13 and and CC cord-305859-vt8vwo3y 23 14 was be VBD cord-305859-vt8vwo3y 23 15 previously previously RB cord-305859-vt8vwo3y 23 16 reported report VBN cord-305859-vt8vwo3y 23 17 in in IN cord-305859-vt8vwo3y 23 18 birds bird NNS cord-305859-vt8vwo3y 23 19 [ [ -LRB- cord-305859-vt8vwo3y 23 20 10 10 CD cord-305859-vt8vwo3y 23 21 ] ] -RRB- cord-305859-vt8vwo3y 23 22 . . . cord-305859-vt8vwo3y 24 1 PDCoV PDCoV NNP cord-305859-vt8vwo3y 24 2 was be VBD cord-305859-vt8vwo3y 24 3 first first RB cord-305859-vt8vwo3y 24 4 identified identify VBN cord-305859-vt8vwo3y 24 5 in in IN cord-305859-vt8vwo3y 24 6 pigs pig NNS cord-305859-vt8vwo3y 24 7 in in IN cord-305859-vt8vwo3y 24 8 Hong Hong NNP cord-305859-vt8vwo3y 24 9 Kong Kong NNP cord-305859-vt8vwo3y 24 10 in in IN cord-305859-vt8vwo3y 24 11 2012 2012 CD cord-305859-vt8vwo3y 24 12 [ [ -LRB- cord-305859-vt8vwo3y 24 13 18 18 CD cord-305859-vt8vwo3y 24 14 ] ] -RRB- cord-305859-vt8vwo3y 24 15 and and CC cord-305859-vt8vwo3y 24 16 the the DT cord-305859-vt8vwo3y 24 17 associated associate VBN cord-305859-vt8vwo3y 24 18 enteric enteric JJ cord-305859-vt8vwo3y 24 19 disease disease NN cord-305859-vt8vwo3y 24 20 was be VBD cord-305859-vt8vwo3y 24 21 first first RB cord-305859-vt8vwo3y 24 22 reported report VBN cord-305859-vt8vwo3y 24 23 in in IN cord-305859-vt8vwo3y 24 24 US US NNP cord-305859-vt8vwo3y 24 25 swine swine NN cord-305859-vt8vwo3y 24 26 only only RB cord-305859-vt8vwo3y 24 27 in in IN cord-305859-vt8vwo3y 24 28 early early JJ cord-305859-vt8vwo3y 24 29 2014 2014 CD cord-305859-vt8vwo3y 24 30 [ [ -LRB- cord-305859-vt8vwo3y 24 31 17 17 CD cord-305859-vt8vwo3y 24 32 ] ] -RRB- cord-305859-vt8vwo3y 24 33 . . . cord-305859-vt8vwo3y 25 1 However however RB cord-305859-vt8vwo3y 25 2 , , , cord-305859-vt8vwo3y 25 3 the the DT cord-305859-vt8vwo3y 25 4 origin origin NN cord-305859-vt8vwo3y 25 5 of of IN cord-305859-vt8vwo3y 25 6 PDCoV pdcov JJ cord-305859-vt8vwo3y 25 7 infection infection NN cord-305859-vt8vwo3y 25 8 in in IN cord-305859-vt8vwo3y 25 9 pigs pig NNS cord-305859-vt8vwo3y 25 10 and and CC cord-305859-vt8vwo3y 25 11 also also RB cord-305859-vt8vwo3y 25 12 the the DT cord-305859-vt8vwo3y 25 13 sudden sudden JJ cord-305859-vt8vwo3y 25 14 emergence emergence NN cord-305859-vt8vwo3y 25 15 and and CC cord-305859-vt8vwo3y 25 16 route route NN cord-305859-vt8vwo3y 25 17 of of IN cord-305859-vt8vwo3y 25 18 introduction introduction NN cord-305859-vt8vwo3y 25 19 of of IN cord-305859-vt8vwo3y 25 20 this this DT cord-305859-vt8vwo3y 25 21 virus virus NN cord-305859-vt8vwo3y 25 22 in in IN cord-305859-vt8vwo3y 25 23 the the DT cord-305859-vt8vwo3y 25 24 US US NNP cord-305859-vt8vwo3y 25 25 remains remain VBZ cord-305859-vt8vwo3y 25 26 unclear unclear JJ cord-305859-vt8vwo3y 25 27 [ [ -LRB- cord-305859-vt8vwo3y 25 28 10 10 CD cord-305859-vt8vwo3y 25 29 ] ] -RRB- cord-305859-vt8vwo3y 25 30 . . . cord-305859-vt8vwo3y 26 1 PDCoV PDCoV NNP cord-305859-vt8vwo3y 26 2 may may MD cord-305859-vt8vwo3y 26 3 have have VB cord-305859-vt8vwo3y 26 4 only only RB cord-305859-vt8vwo3y 26 5 partially partially RB cord-305859-vt8vwo3y 26 6 adapted adapt VBN cord-305859-vt8vwo3y 26 7 to to IN cord-305859-vt8vwo3y 26 8 pigs pig NNS cord-305859-vt8vwo3y 26 9 and and CC cord-305859-vt8vwo3y 26 10 still still RB cord-305859-vt8vwo3y 26 11 retain retain VB cord-305859-vt8vwo3y 26 12 some some DT cord-305859-vt8vwo3y 26 13 potential potential NN cord-305859-vt8vwo3y 26 14 to to TO cord-305859-vt8vwo3y 26 15 infect infect VB cord-305859-vt8vwo3y 26 16 different different JJ cord-305859-vt8vwo3y 26 17 animal animal NN cord-305859-vt8vwo3y 26 18 species specie NNS cord-305859-vt8vwo3y 26 19 , , , cord-305859-vt8vwo3y 26 20 particularly particularly RB cord-305859-vt8vwo3y 26 21 poultry poultry NN cord-305859-vt8vwo3y 26 22 or or CC cord-305859-vt8vwo3y 26 23 other other JJ cord-305859-vt8vwo3y 26 24 livestock livestock NN cord-305859-vt8vwo3y 26 25 , , , cord-305859-vt8vwo3y 26 26 which which WDT cord-305859-vt8vwo3y 26 27 can can MD cord-305859-vt8vwo3y 26 28 often often RB cord-305859-vt8vwo3y 26 29 have have VB cord-305859-vt8vwo3y 26 30 frequent frequent JJ cord-305859-vt8vwo3y 26 31 contact contact NN cord-305859-vt8vwo3y 26 32 with with IN cord-305859-vt8vwo3y 26 33 pigs pig NNS cord-305859-vt8vwo3y 26 34 in in IN cord-305859-vt8vwo3y 26 35 small small JJ cord-305859-vt8vwo3y 26 36 - - HYPH cord-305859-vt8vwo3y 26 37 scale scale NN cord-305859-vt8vwo3y 26 38 , , , cord-305859-vt8vwo3y 26 39 backyard backyard NN cord-305859-vt8vwo3y 26 40 farms farm NNS cord-305859-vt8vwo3y 26 41 in in IN cord-305859-vt8vwo3y 26 42 the the DT cord-305859-vt8vwo3y 26 43 US US NNP cord-305859-vt8vwo3y 26 44 . . . cord-305859-vt8vwo3y 27 1 Therefore therefore RB cord-305859-vt8vwo3y 27 2 , , , cord-305859-vt8vwo3y 27 3 our -PRON- PRP$ cord-305859-vt8vwo3y 27 4 aim aim NN cord-305859-vt8vwo3y 27 5 was be VBD cord-305859-vt8vwo3y 27 6 to to TO cord-305859-vt8vwo3y 27 7 determine determine VB cord-305859-vt8vwo3y 27 8 whether whether IN cord-305859-vt8vwo3y 27 9 calves calf NNS cord-305859-vt8vwo3y 27 10 are be VBP cord-305859-vt8vwo3y 27 11 susceptible susceptible JJ cord-305859-vt8vwo3y 27 12 to to IN cord-305859-vt8vwo3y 27 13 infection infection NN cord-305859-vt8vwo3y 27 14 with with IN cord-305859-vt8vwo3y 27 15 either either CC cord-305859-vt8vwo3y 27 16 the the DT cord-305859-vt8vwo3y 27 17 newly newly RB cord-305859-vt8vwo3y 27 18 emerged emerge VBN cord-305859-vt8vwo3y 27 19 PDCoV pdcov JJ cord-305859-vt8vwo3y 27 20 or or CC cord-305859-vt8vwo3y 27 21 the the DT cord-305859-vt8vwo3y 27 22 swine swine NNP cord-305859-vt8vwo3y 27 23 enteric enteric JJ cord-305859-vt8vwo3y 27 24 CoV cov NN cord-305859-vt8vwo3y 27 25 , , , cord-305859-vt8vwo3y 27 26 PEDV PEDV NNP cord-305859-vt8vwo3y 27 27 . . . cord-305859-vt8vwo3y 28 1 Fecal fecal JJ cord-305859-vt8vwo3y 28 2 virus virus NN cord-305859-vt8vwo3y 28 3 shedding shed VBG cord-305859-vt8vwo3y 28 4 , , , cord-305859-vt8vwo3y 28 5 seroconversion seroconversion NN cord-305859-vt8vwo3y 28 6 and and CC cord-305859-vt8vwo3y 28 7 histopathology histopathology NN cord-305859-vt8vwo3y 28 8 were be VBD cord-305859-vt8vwo3y 28 9 evaluated evaluate VBN cord-305859-vt8vwo3y 28 10 in in IN cord-305859-vt8vwo3y 28 11 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 28 12 ( ( -LRB- cord-305859-vt8vwo3y 28 13 Gn Gn NNP cord-305859-vt8vwo3y 28 14 ) ) -RRB- cord-305859-vt8vwo3y 28 15 calves calf NNS cord-305859-vt8vwo3y 28 16 orally orally RB cord-305859-vt8vwo3y 28 17 inoculated inoculate VBD cord-305859-vt8vwo3y 28 18 with with IN cord-305859-vt8vwo3y 28 19 PDCoV pdcov ADD cord-305859-vt8vwo3y 28 20 or or CC cord-305859-vt8vwo3y 28 21 PEDV PEDV NNP cord-305859-vt8vwo3y 28 22 . . . cord-305859-vt8vwo3y 29 1 The the DT cord-305859-vt8vwo3y 29 2 PDCoV pdcov NN cord-305859-vt8vwo3y 29 3 OH OH NNP cord-305859-vt8vwo3y 29 4 - - HYPH cord-305859-vt8vwo3y 29 5 FD22 FD22 NNP cord-305859-vt8vwo3y 29 6 virus virus NN cord-305859-vt8vwo3y 29 7 was be VBD cord-305859-vt8vwo3y 29 8 isolated isolate VBN cord-305859-vt8vwo3y 29 9 and and CC cord-305859-vt8vwo3y 29 10 then then RB cord-305859-vt8vwo3y 29 11 serially serially RB cord-305859-vt8vwo3y 29 12 passaged passage VBD cord-305859-vt8vwo3y 29 13 five five CD cord-305859-vt8vwo3y 29 14 times time NNS cord-305859-vt8vwo3y 29 15 ( ( -LRB- cord-305859-vt8vwo3y 29 16 P5 p5 NN cord-305859-vt8vwo3y 29 17 ) ) -RRB- cord-305859-vt8vwo3y 29 18 in in IN cord-305859-vt8vwo3y 29 19 LLC LLC NNP cord-305859-vt8vwo3y 29 20 porcine porcine JJ cord-305859-vt8vwo3y 29 21 kidney kidney NN cord-305859-vt8vwo3y 29 22 ( ( -LRB- cord-305859-vt8vwo3y 29 23 LLC LLC NNP cord-305859-vt8vwo3y 29 24 - - HYPH cord-305859-vt8vwo3y 29 25 PK PK NNP cord-305859-vt8vwo3y 29 26 ) ) -RRB- cord-305859-vt8vwo3y 29 27 cells cell NNS cord-305859-vt8vwo3y 29 28 ( ( -LRB- cord-305859-vt8vwo3y 29 29 ATCC ATCC NNP cord-305859-vt8vwo3y 29 30 CL-101 cl-101 NN cord-305859-vt8vwo3y 29 31 ) ) -RRB- cord-305859-vt8vwo3y 30 1 [ [ -LRB- cord-305859-vt8vwo3y 30 2 2 2 CD cord-305859-vt8vwo3y 30 3 ] ] -RRB- cord-305859-vt8vwo3y 30 4 . . . cord-305859-vt8vwo3y 31 1 The the DT cord-305859-vt8vwo3y 31 2 virus virus NN cord-305859-vt8vwo3y 31 3 was be VBD cord-305859-vt8vwo3y 31 4 orally orally RB cord-305859-vt8vwo3y 31 5 inoculated inoculate VBN cord-305859-vt8vwo3y 31 6 and and CC cord-305859-vt8vwo3y 31 7 propagated propagate VBN cord-305859-vt8vwo3y 31 8 in in IN cord-305859-vt8vwo3y 31 9 a a DT cord-305859-vt8vwo3y 31 10 9-day 9-day JJ cord-305859-vt8vwo3y 31 11 - - HYPH cord-305859-vt8vwo3y 31 12 old old JJ cord-305859-vt8vwo3y 31 13 Gn Gn NNP cord-305859-vt8vwo3y 31 14 pig pig NN cord-305859-vt8vwo3y 31 15 . . . cord-305859-vt8vwo3y 32 1 The the DT cord-305859-vt8vwo3y 32 2 viral viral JJ cord-305859-vt8vwo3y 32 3 RNA RNA NNP cord-305859-vt8vwo3y 32 4 titer titer NN cord-305859-vt8vwo3y 32 5 of of IN cord-305859-vt8vwo3y 32 6 OH OH NNP cord-305859-vt8vwo3y 32 7 - - HYPH cord-305859-vt8vwo3y 32 8 FD22-P5 FD22-P5 NNP cord-305859-vt8vwo3y 32 9 used use VBN cord-305859-vt8vwo3y 32 10 as as IN cord-305859-vt8vwo3y 32 11 inoculum inoculum NN cord-305859-vt8vwo3y 32 12 in in IN cord-305859-vt8vwo3y 32 13 the the DT cord-305859-vt8vwo3y 32 14 intestinal intestinal JJ cord-305859-vt8vwo3y 32 15 contents content NNS cord-305859-vt8vwo3y 32 16 ( ( -LRB- cord-305859-vt8vwo3y 32 17 ICs ICs NNP cord-305859-vt8vwo3y 32 18 ) ) -RRB- cord-305859-vt8vwo3y 32 19 was be VBD cord-305859-vt8vwo3y 32 20 9.0 9.0 CD cord-305859-vt8vwo3y 32 21 log log NN cord-305859-vt8vwo3y 32 22 10 10 CD cord-305859-vt8vwo3y 32 23 genomic genomic JJ cord-305859-vt8vwo3y 32 24 equivalents equivalent NNS cord-305859-vt8vwo3y 32 25 ( ( -LRB- cord-305859-vt8vwo3y 32 26 GE)/ml GE)/ml NNP cord-305859-vt8vwo3y 32 27 . . . cord-305859-vt8vwo3y 33 1 The the DT cord-305859-vt8vwo3y 33 2 wild wild JJ cord-305859-vt8vwo3y 33 3 - - HYPH cord-305859-vt8vwo3y 33 4 type type NN cord-305859-vt8vwo3y 33 5 US US NNP cord-305859-vt8vwo3y 33 6 PEDV PEDV NNP cord-305859-vt8vwo3y 33 7 strain strain NN cord-305859-vt8vwo3y 33 8 PC21A pc21a NN cord-305859-vt8vwo3y 33 9 , , , cord-305859-vt8vwo3y 33 10 propagated propagate VBN cord-305859-vt8vwo3y 33 11 in in IN cord-305859-vt8vwo3y 33 12 a a DT cord-305859-vt8vwo3y 33 13 Gn Gn NNP cord-305859-vt8vwo3y 33 14 pig pig NN cord-305859-vt8vwo3y 33 15 [ [ -LRB- cord-305859-vt8vwo3y 33 16 7 7 CD cord-305859-vt8vwo3y 33 17 ] ] -RRB- cord-305859-vt8vwo3y 33 18 , , , cord-305859-vt8vwo3y 33 19 was be VBD cord-305859-vt8vwo3y 33 20 also also RB cord-305859-vt8vwo3y 33 21 used use VBN cord-305859-vt8vwo3y 33 22 in in IN cord-305859-vt8vwo3y 33 23 this this DT cord-305859-vt8vwo3y 33 24 study study NN cord-305859-vt8vwo3y 33 25 . . . cord-305859-vt8vwo3y 34 1 All all DT cord-305859-vt8vwo3y 34 2 ICs ic NNS cord-305859-vt8vwo3y 34 3 were be VBD cord-305859-vt8vwo3y 34 4 negative negative JJ cord-305859-vt8vwo3y 34 5 for for IN cord-305859-vt8vwo3y 34 6 other other JJ cord-305859-vt8vwo3y 34 7 enteric enteric JJ cord-305859-vt8vwo3y 34 8 viruses virus NNS cord-305859-vt8vwo3y 34 9 , , , cord-305859-vt8vwo3y 34 10 such such JJ cord-305859-vt8vwo3y 34 11 as as IN cord-305859-vt8vwo3y 34 12 rotavirus rotavirus JJ cord-305859-vt8vwo3y 34 13 groups group NNS cord-305859-vt8vwo3y 34 14 A A NNP cord-305859-vt8vwo3y 34 15 - - HYPH cord-305859-vt8vwo3y 34 16 C C NNP cord-305859-vt8vwo3y 34 17 , , , cord-305859-vt8vwo3y 34 18 by by IN cord-305859-vt8vwo3y 34 19 PCR PCR NNP cord-305859-vt8vwo3y 34 20 / / SYM cord-305859-vt8vwo3y 34 21 RT RT NNP cord-305859-vt8vwo3y 34 22 - - HYPH cord-305859-vt8vwo3y 34 23 PCR PCR NNP cord-305859-vt8vwo3y 34 24 [ [ -LRB- cord-305859-vt8vwo3y 34 25 6 6 CD cord-305859-vt8vwo3y 34 26 ] ] -RRB- cord-305859-vt8vwo3y 34 27 . . . cord-305859-vt8vwo3y 35 1 Near near JJ cord-305859-vt8vwo3y 35 2 - - HYPH cord-305859-vt8vwo3y 35 3 term term NN cord-305859-vt8vwo3y 35 4 Angus Angus NNP cord-305859-vt8vwo3y 35 5 9 9 CD cord-305859-vt8vwo3y 35 6 Jersey Jersey NNP cord-305859-vt8vwo3y 35 7 crossbred crossbreed VBD cord-305859-vt8vwo3y 35 8 Gn Gn NNP cord-305859-vt8vwo3y 35 9 calves calf NNS cord-305859-vt8vwo3y 35 10 were be VBD cord-305859-vt8vwo3y 35 11 delivered deliver VBN cord-305859-vt8vwo3y 35 12 aseptically aseptically RB cord-305859-vt8vwo3y 35 13 by by IN cord-305859-vt8vwo3y 35 14 caesarean caesarean NN cord-305859-vt8vwo3y 35 15 section section NN cord-305859-vt8vwo3y 35 16 [ [ -LRB- cord-305859-vt8vwo3y 35 17 5 5 CD cord-305859-vt8vwo3y 35 18 ] ] -RRB- cord-305859-vt8vwo3y 35 19 . . . cord-305859-vt8vwo3y 36 1 Eight eight CD cord-305859-vt8vwo3y 36 2 3-to 3-to CD cord-305859-vt8vwo3y 36 3 7-day 7-day JJ cord-305859-vt8vwo3y 36 4 - - HYPH cord-305859-vt8vwo3y 36 5 old old JJ cord-305859-vt8vwo3y 36 6 calves calf NNS cord-305859-vt8vwo3y 36 7 were be VBD cord-305859-vt8vwo3y 36 8 randomly randomly RB cord-305859-vt8vwo3y 36 9 assigned assign VBN cord-305859-vt8vwo3y 36 10 to to IN cord-305859-vt8vwo3y 36 11 three three CD cord-305859-vt8vwo3y 36 12 groups group NNS cord-305859-vt8vwo3y 36 13 : : : cord-305859-vt8vwo3y 37 1 PDCoV pdcov JJ cord-305859-vt8vwo3y 37 2 infection infection NN cord-305859-vt8vwo3y 37 3 ( ( -LRB- cord-305859-vt8vwo3y 37 4 n=4 n=4 NNS cord-305859-vt8vwo3y 37 5 ; ; : cord-305859-vt8vwo3y 37 6 calves calf NNS cord-305859-vt8vwo3y 37 7 # # $ cord-305859-vt8vwo3y 37 8 1 1 CD cord-305859-vt8vwo3y 37 9 - - SYM cord-305859-vt8vwo3y 37 10 4 4 CD cord-305859-vt8vwo3y 37 11 ) ) -RRB- cord-305859-vt8vwo3y 37 12 , , , cord-305859-vt8vwo3y 37 13 PEDV PEDV NNP cord-305859-vt8vwo3y 37 14 infection infection NN cord-305859-vt8vwo3y 37 15 ( ( -LRB- cord-305859-vt8vwo3y 37 16 n=3 n=3 NN cord-305859-vt8vwo3y 37 17 ; ; : cord-305859-vt8vwo3y 37 18 calves calf NNS cord-305859-vt8vwo3y 37 19 # # $ cord-305859-vt8vwo3y 37 20 5 5 CD cord-305859-vt8vwo3y 37 21 - - SYM cord-305859-vt8vwo3y 37 22 7 7 CD cord-305859-vt8vwo3y 37 23 ) ) -RRB- cord-305859-vt8vwo3y 37 24 , , , cord-305859-vt8vwo3y 37 25 and and CC cord-305859-vt8vwo3y 37 26 mock mock JJ cord-305859-vt8vwo3y 37 27 ( ( -LRB- cord-305859-vt8vwo3y 37 28 minimum minimum JJ cord-305859-vt8vwo3y 37 29 essential essential JJ cord-305859-vt8vwo3y 37 30 medium medium NN cord-305859-vt8vwo3y 37 31 [ [ -LRB- cord-305859-vt8vwo3y 37 32 MEM mem NN cord-305859-vt8vwo3y 37 33 ] ] -RRB- cord-305859-vt8vwo3y 37 34 ; ; : cord-305859-vt8vwo3y 37 35 n=1 n=1 UH cord-305859-vt8vwo3y 37 36 ; ; : cord-305859-vt8vwo3y 37 37 calf calf NN cord-305859-vt8vwo3y 37 38 # # $ cord-305859-vt8vwo3y 37 39 8 8 CD cord-305859-vt8vwo3y 37 40 , , , cord-305859-vt8vwo3y 37 41 3 3 CD cord-305859-vt8vwo3y 37 42 days day NNS cord-305859-vt8vwo3y 37 43 of of IN cord-305859-vt8vwo3y 37 44 age age NN cord-305859-vt8vwo3y 37 45 ) ) -RRB- cord-305859-vt8vwo3y 37 46 ( ( -LRB- cord-305859-vt8vwo3y 37 47 Table table NN cord-305859-vt8vwo3y 37 48 1 1 CD cord-305859-vt8vwo3y 37 49 ) ) -RRB- cord-305859-vt8vwo3y 37 50 . . . cord-305859-vt8vwo3y 38 1 Calves calf NNS cord-305859-vt8vwo3y 38 2 # # $ cord-305859-vt8vwo3y 38 3 1 1 CD cord-305859-vt8vwo3y 38 4 - - SYM cord-305859-vt8vwo3y 38 5 4 4 CD cord-305859-vt8vwo3y 38 6 were be VBD cord-305859-vt8vwo3y 38 7 inoculated inoculate VBN cord-305859-vt8vwo3y 38 8 orally orally RB cord-305859-vt8vwo3y 38 9 with with IN cord-305859-vt8vwo3y 38 10 9.0 9.0 CD cord-305859-vt8vwo3y 38 11 - - HYPH cord-305859-vt8vwo3y 38 12 9.6 9.6 CD cord-305859-vt8vwo3y 38 13 log log NN cord-305859-vt8vwo3y 38 14 10 10 CD cord-305859-vt8vwo3y 38 15 GE GE NNP cord-305859-vt8vwo3y 38 16 of of IN cord-305859-vt8vwo3y 38 17 the the DT cord-305859-vt8vwo3y 38 18 OH OH NNP cord-305859-vt8vwo3y 38 19 - - HYPH cord-305859-vt8vwo3y 38 20 FD22-P5 FD22-P5 NNP cord-305859-vt8vwo3y 38 21 , , , cord-305859-vt8vwo3y 38 22 and and CC cord-305859-vt8vwo3y 38 23 calves calf NNS cord-305859-vt8vwo3y 38 24 # # $ cord-305859-vt8vwo3y 38 25 5 5 CD cord-305859-vt8vwo3y 38 26 - - SYM cord-305859-vt8vwo3y 38 27 7 7 CD cord-305859-vt8vwo3y 38 28 were be VBD cord-305859-vt8vwo3y 38 29 inoculated inoculate VBN cord-305859-vt8vwo3y 38 30 orally orally RB cord-305859-vt8vwo3y 38 31 with with IN cord-305859-vt8vwo3y 38 32 10.2 10.2 CD cord-305859-vt8vwo3y 38 33 - - SYM cord-305859-vt8vwo3y 38 34 12.5 12.5 CD cord-305859-vt8vwo3y 38 35 log log NN cord-305859-vt8vwo3y 38 36 10 10 CD cord-305859-vt8vwo3y 38 37 GE GE NNP cord-305859-vt8vwo3y 38 38 of of IN cord-305859-vt8vwo3y 38 39 the the DT cord-305859-vt8vwo3y 39 1 PC21A pc21a JJ cord-305859-vt8vwo3y 40 1 ( ( -LRB- cord-305859-vt8vwo3y 40 2 Table table NN cord-305859-vt8vwo3y 40 3 1 1 CD cord-305859-vt8vwo3y 40 4 ) ) -RRB- cord-305859-vt8vwo3y 40 5 . . . cord-305859-vt8vwo3y 41 1 After after IN cord-305859-vt8vwo3y 41 2 viral viral JJ cord-305859-vt8vwo3y 41 3 inoculation inoculation NN cord-305859-vt8vwo3y 41 4 , , , cord-305859-vt8vwo3y 41 5 we -PRON- PRP cord-305859-vt8vwo3y 41 6 monitored monitor VBD cord-305859-vt8vwo3y 41 7 clinical clinical JJ cord-305859-vt8vwo3y 41 8 signs sign NNS cord-305859-vt8vwo3y 41 9 daily daily RB cord-305859-vt8vwo3y 41 10 . . . cord-305859-vt8vwo3y 42 1 Diarrhea diarrhea NN cord-305859-vt8vwo3y 42 2 was be VBD cord-305859-vt8vwo3y 42 3 assessed assess VBN cord-305859-vt8vwo3y 42 4 by by IN cord-305859-vt8vwo3y 42 5 scoring score VBG cord-305859-vt8vwo3y 42 6 fecal fecal JJ cord-305859-vt8vwo3y 42 7 consistency consistency NN cord-305859-vt8vwo3y 42 8 as as IN cord-305859-vt8vwo3y 42 9 follows follow VBZ cord-305859-vt8vwo3y 42 10 : : : cord-305859-vt8vwo3y 42 11 0 0 NFP cord-305859-vt8vwo3y 42 12 = = SYM cord-305859-vt8vwo3y 42 13 solid solid JJ cord-305859-vt8vwo3y 42 14 ; ; . cord-305859-vt8vwo3y 43 1 1 1 LS cord-305859-vt8vwo3y 43 2 = = SYM cord-305859-vt8vwo3y 43 3 pasty pasty JJ cord-305859-vt8vwo3y 43 4 ; ; : cord-305859-vt8vwo3y 43 5 2 2 CD cord-305859-vt8vwo3y 43 6 = = SYM cord-305859-vt8vwo3y 43 7 semi semi JJ cord-305859-vt8vwo3y 43 8 - - JJ cord-305859-vt8vwo3y 43 9 liquid liquid JJ cord-305859-vt8vwo3y 43 10 ; ; : cord-305859-vt8vwo3y 43 11 3 3 CD cord-305859-vt8vwo3y 43 12 = = SYM cord-305859-vt8vwo3y 43 13 liquid liquid NN cord-305859-vt8vwo3y 43 14 , , , cord-305859-vt8vwo3y 43 15 with with IN cord-305859-vt8vwo3y 43 16 scores score NNS cord-305859-vt8vwo3y 43 17 of of IN cord-305859-vt8vwo3y 43 18 2 2 CD cord-305859-vt8vwo3y 43 19 or or CC cord-305859-vt8vwo3y 43 20 more more RBR cord-305859-vt8vwo3y 43 21 considered consider VBN cord-305859-vt8vwo3y 43 22 diarrheic diarrheic NNS cord-305859-vt8vwo3y 43 23 . . . cord-305859-vt8vwo3y 44 1 Calves calf NNS cord-305859-vt8vwo3y 44 2 # # $ cord-305859-vt8vwo3y 44 3 1 1 CD cord-305859-vt8vwo3y 44 4 ( ( -LRB- cord-305859-vt8vwo3y 44 5 PDCoV pdcov UH cord-305859-vt8vwo3y 44 6 ) ) -RRB- cord-305859-vt8vwo3y 44 7 and and CC cord-305859-vt8vwo3y 44 8 # # $ cord-305859-vt8vwo3y 44 9 5 5 CD cord-305859-vt8vwo3y 44 10 ( ( -LRB- cord-305859-vt8vwo3y 44 11 PEDV PEDV NNP cord-305859-vt8vwo3y 44 12 ) ) -RRB- cord-305859-vt8vwo3y 44 13 were be VBD cord-305859-vt8vwo3y 44 14 monitored monitor VBN cord-305859-vt8vwo3y 44 15 for for IN cord-305859-vt8vwo3y 44 16 long long JJ cord-305859-vt8vwo3y 44 17 - - HYPH cord-305859-vt8vwo3y 44 18 term term NN cord-305859-vt8vwo3y 44 19 clinical clinical JJ cord-305859-vt8vwo3y 44 20 signs sign NNS cord-305859-vt8vwo3y 44 21 and and CC cord-305859-vt8vwo3y 44 22 virus virus NN cord-305859-vt8vwo3y 44 23 shedding shed VBG cord-305859-vt8vwo3y 44 24 until until IN cord-305859-vt8vwo3y 44 25 post post JJ cord-305859-vt8vwo3y 44 26 - - JJ cord-305859-vt8vwo3y 44 27 inoculation inoculation JJ cord-305859-vt8vwo3y 44 28 day day NN cord-305859-vt8vwo3y 44 29 ( ( -LRB- cord-305859-vt8vwo3y 44 30 PID PID NNP cord-305859-vt8vwo3y 44 31 ) ) -RRB- cord-305859-vt8vwo3y 44 32 16 16 CD cord-305859-vt8vwo3y 44 33 - - SYM cord-305859-vt8vwo3y 44 34 17 17 CD cord-305859-vt8vwo3y 44 35 . . . cord-305859-vt8vwo3y 45 1 The the DT cord-305859-vt8vwo3y 45 2 other other JJ cord-305859-vt8vwo3y 45 3 inoculated inoculate VBD cord-305859-vt8vwo3y 45 4 or or CC cord-305859-vt8vwo3y 45 5 mock mock JJ cord-305859-vt8vwo3y 45 6 - - HYPH cord-305859-vt8vwo3y 45 7 infected infect VBN cord-305859-vt8vwo3y 45 8 calves calf NNS cord-305859-vt8vwo3y 45 9 were be VBD cord-305859-vt8vwo3y 45 10 kept keep VBN cord-305859-vt8vwo3y 45 11 for for IN cord-305859-vt8vwo3y 45 12 short short JJ cord-305859-vt8vwo3y 45 13 - - HYPH cord-305859-vt8vwo3y 45 14 term term NN cord-305859-vt8vwo3y 45 15 studies study NNS cord-305859-vt8vwo3y 45 16 and and CC cord-305859-vt8vwo3y 45 17 were be VBD cord-305859-vt8vwo3y 45 18 euthanized euthanize VBN cord-305859-vt8vwo3y 45 19 for for IN cord-305859-vt8vwo3y 45 20 histopathological histopathological JJ cord-305859-vt8vwo3y 45 21 examination examination NN cord-305859-vt8vwo3y 45 22 at at IN cord-305859-vt8vwo3y 45 23 acute acute JJ cord-305859-vt8vwo3y 45 24 to to IN cord-305859-vt8vwo3y 45 25 mild mild JJ cord-305859-vt8vwo3y 45 26 stages stage NNS cord-305859-vt8vwo3y 45 27 ( ( -LRB- cord-305859-vt8vwo3y 45 28 PIDs PIDs NNP cord-305859-vt8vwo3y 45 29 3 3 CD cord-305859-vt8vwo3y 45 30 , , , cord-305859-vt8vwo3y 45 31 8 8 CD cord-305859-vt8vwo3y 45 32 or or CC cord-305859-vt8vwo3y 45 33 9 9 CD cord-305859-vt8vwo3y 45 34 ) ) -RRB- cord-305859-vt8vwo3y 45 35 of of IN cord-305859-vt8vwo3y 45 36 viral viral JJ cord-305859-vt8vwo3y 45 37 infection infection NN cord-305859-vt8vwo3y 45 38 ( ( -LRB- cord-305859-vt8vwo3y 45 39 Table table NN cord-305859-vt8vwo3y 45 40 1 1 CD cord-305859-vt8vwo3y 45 41 ) ) -RRB- cord-305859-vt8vwo3y 45 42 . . . cord-305859-vt8vwo3y 46 1 Rectal rectal JJ cord-305859-vt8vwo3y 46 2 and and CC cord-305859-vt8vwo3y 46 3 nasal nasal NN cord-305859-vt8vwo3y 46 4 swabs swab NNS cord-305859-vt8vwo3y 46 5 or or CC cord-305859-vt8vwo3y 46 6 serum serum NN cord-305859-vt8vwo3y 46 7 samples sample NNS cord-305859-vt8vwo3y 46 8 were be VBD cord-305859-vt8vwo3y 46 9 collected collect VBN cord-305859-vt8vwo3y 46 10 and and CC cord-305859-vt8vwo3y 46 11 prepared prepare VBN cord-305859-vt8vwo3y 46 12 as as IN cord-305859-vt8vwo3y 46 13 described describe VBN cord-305859-vt8vwo3y 46 14 previously previously RB cord-305859-vt8vwo3y 46 15 [ [ -LRB- cord-305859-vt8vwo3y 46 16 4 4 CD cord-305859-vt8vwo3y 46 17 , , , cord-305859-vt8vwo3y 46 18 6 6 CD cord-305859-vt8vwo3y 46 19 ] ] -RRB- cord-305859-vt8vwo3y 46 20 . . . cord-305859-vt8vwo3y 47 1 Rectal rectal JJ cord-305859-vt8vwo3y 47 2 and and CC cord-305859-vt8vwo3y 47 3 nasal nasal NN cord-305859-vt8vwo3y 47 4 swabs swab NNS cord-305859-vt8vwo3y 47 5 were be VBD cord-305859-vt8vwo3y 47 6 diluted dilute VBN cord-305859-vt8vwo3y 47 7 1:10 1:10 CD cord-305859-vt8vwo3y 47 8 and and CC cord-305859-vt8vwo3y 47 9 1:50 1:50 CD cord-305859-vt8vwo3y 47 10 , , , cord-305859-vt8vwo3y 47 11 respectively respectively RB cord-305859-vt8vwo3y 47 12 , , , cord-305859-vt8vwo3y 47 13 in in IN cord-305859-vt8vwo3y 47 14 MEM MEM NNP cord-305859-vt8vwo3y 47 15 . . . cord-305859-vt8vwo3y 48 1 Virus Virus NNP cord-305859-vt8vwo3y 48 2 RNA RNA NNP cord-305859-vt8vwo3y 48 3 was be VBD cord-305859-vt8vwo3y 48 4 extracted extract VBN cord-305859-vt8vwo3y 48 5 using use VBG cord-305859-vt8vwo3y 48 6 the the DT cord-305859-vt8vwo3y 48 7 Mag Mag NNP cord-305859-vt8vwo3y 48 8 - - HYPH cord-305859-vt8vwo3y 48 9 MAX MAX NNP cord-305859-vt8vwo3y 48 10 Viral Viral NNP cord-305859-vt8vwo3y 48 11 RNA RNA NNP cord-305859-vt8vwo3y 48 12 Isolation Isolation NNP cord-305859-vt8vwo3y 48 13 Kit kit NN cord-305859-vt8vwo3y 48 14 ( ( -LRB- cord-305859-vt8vwo3y 48 15 Applied Applied NNP cord-305859-vt8vwo3y 48 16 Biosystems Biosystems NNP cord-305859-vt8vwo3y 48 17 , , , cord-305859-vt8vwo3y 48 18 Foster Foster NNP cord-305859-vt8vwo3y 48 19 City City NNP cord-305859-vt8vwo3y 48 20 , , , cord-305859-vt8vwo3y 48 21 CA CA NNP cord-305859-vt8vwo3y 48 22 , , , cord-305859-vt8vwo3y 48 23 USA USA NNP cord-305859-vt8vwo3y 48 24 ) ) -RRB- cord-305859-vt8vwo3y 48 25 according accord VBG cord-305859-vt8vwo3y 48 26 to to IN cord-305859-vt8vwo3y 48 27 the the DT cord-305859-vt8vwo3y 48 28 manufacturer manufacturer NN cord-305859-vt8vwo3y 48 29 's 's POS cord-305859-vt8vwo3y 48 30 instructions instruction NNS cord-305859-vt8vwo3y 48 31 . . . cord-305859-vt8vwo3y 49 1 Titers Titers NNP cord-305859-vt8vwo3y 49 2 of of IN cord-305859-vt8vwo3y 49 3 virus virus NN cord-305859-vt8vwo3y 49 4 shed shed VBN cord-305859-vt8vwo3y 49 5 in in IN cord-305859-vt8vwo3y 49 6 feces fece NNS cord-305859-vt8vwo3y 49 7 were be VBD cord-305859-vt8vwo3y 49 8 determined determine VBN cord-305859-vt8vwo3y 49 9 by by IN cord-305859-vt8vwo3y 49 10 qRT qRT NNP cord-305859-vt8vwo3y 49 11 - - HYPH cord-305859-vt8vwo3y 49 12 PCR PCR NNP cord-305859-vt8vwo3y 49 13 using use VBG cord-305859-vt8vwo3y 49 14 the the DT cord-305859-vt8vwo3y 49 15 OneStep OneStep NNP cord-305859-vt8vwo3y 49 16 RT RT NNP cord-305859-vt8vwo3y 49 17 - - HYPH cord-305859-vt8vwo3y 49 18 PCR PCR NNP cord-305859-vt8vwo3y 49 19 Kit kit NN cord-305859-vt8vwo3y 49 20 ( ( -LRB- cord-305859-vt8vwo3y 49 21 QIAGEN QIAGEN NNP cord-305859-vt8vwo3y 49 22 , , , cord-305859-vt8vwo3y 49 23 Valencia Valencia NNP cord-305859-vt8vwo3y 49 24 , , , cord-305859-vt8vwo3y 49 25 CA CA NNP cord-305859-vt8vwo3y 49 26 , , , cord-305859-vt8vwo3y 49 27 USA USA NNP cord-305859-vt8vwo3y 49 28 ) ) -RRB- cord-305859-vt8vwo3y 49 29 [ [ -LRB- cord-305859-vt8vwo3y 49 30 6 6 CD cord-305859-vt8vwo3y 49 31 , , , cord-305859-vt8vwo3y 49 32 8 8 CD cord-305859-vt8vwo3y 49 33 ] ] -RRB- cord-305859-vt8vwo3y 49 34 . . . cord-305859-vt8vwo3y 50 1 The the DT cord-305859-vt8vwo3y 50 2 detection detection NN cord-305859-vt8vwo3y 50 3 limit limit NN cord-305859-vt8vwo3y 50 4 of of IN cord-305859-vt8vwo3y 50 5 qRT qRT NNP cord-305859-vt8vwo3y 50 6 - - HYPH cord-305859-vt8vwo3y 50 7 PCR PCR NNP cord-305859-vt8vwo3y 50 8 for for IN cord-305859-vt8vwo3y 50 9 PDCoV pdcov NN cord-305859-vt8vwo3y 50 10 was be VBD cord-305859-vt8vwo3y 50 11 10 10 CD cord-305859-vt8vwo3y 50 12 GE GE NNP cord-305859-vt8vwo3y 50 13 per per IN cord-305859-vt8vwo3y 50 14 reaction reaction NN cord-305859-vt8vwo3y 50 15 , , , cord-305859-vt8vwo3y 50 16 corresponding correspond VBG cord-305859-vt8vwo3y 50 17 to to IN cord-305859-vt8vwo3y 50 18 5.3 5.3 CD cord-305859-vt8vwo3y 50 19 , , , cord-305859-vt8vwo3y 50 20 4.6 4.6 CD cord-305859-vt8vwo3y 50 21 , , , cord-305859-vt8vwo3y 50 22 and and CC cord-305859-vt8vwo3y 50 23 3.6 3.6 CD cord-305859-vt8vwo3y 50 24 log log NN cord-305859-vt8vwo3y 50 25 10 10 CD cord-305859-vt8vwo3y 50 26 GE GE NNP cord-305859-vt8vwo3y 50 27 / / SYM cord-305859-vt8vwo3y 50 28 ml ml NNS cord-305859-vt8vwo3y 50 29 of of IN cord-305859-vt8vwo3y 50 30 PDCoV pdcov NN cord-305859-vt8vwo3y 50 31 in in IN cord-305859-vt8vwo3y 50 32 nasal nasal NN cord-305859-vt8vwo3y 50 33 , , , cord-305859-vt8vwo3y 50 34 rectal rectal JJ cord-305859-vt8vwo3y 50 35 swab swab NN cord-305859-vt8vwo3y 50 36 , , , cord-305859-vt8vwo3y 50 37 and and CC cord-305859-vt8vwo3y 50 38 serum serum NN cord-305859-vt8vwo3y 50 39 samples sample NNS cord-305859-vt8vwo3y 50 40 , , , cord-305859-vt8vwo3y 50 41 respectively respectively RB cord-305859-vt8vwo3y 50 42 [ [ -LRB- cord-305859-vt8vwo3y 50 43 8 8 CD cord-305859-vt8vwo3y 50 44 ] ] -RRB- cord-305859-vt8vwo3y 50 45 . . . cord-305859-vt8vwo3y 51 1 The the DT cord-305859-vt8vwo3y 51 2 detection detection NN cord-305859-vt8vwo3y 51 3 limit limit NN cord-305859-vt8vwo3y 51 4 of of IN cord-305859-vt8vwo3y 51 5 qRT qRT NNP cord-305859-vt8vwo3y 51 6 - - HYPH cord-305859-vt8vwo3y 51 7 PCR PCR NNP cord-305859-vt8vwo3y 51 8 for for IN cord-305859-vt8vwo3y 51 9 PEDV PEDV NNP cord-305859-vt8vwo3y 51 10 was be VBD cord-305859-vt8vwo3y 51 11 10 10 CD cord-305859-vt8vwo3y 51 12 GE GE NNP cord-305859-vt8vwo3y 51 13 per per IN cord-305859-vt8vwo3y 51 14 reaction reaction NN cord-305859-vt8vwo3y 51 15 , , , cord-305859-vt8vwo3y 51 16 corresponding correspond VBG cord-305859-vt8vwo3y 51 17 to to IN cord-305859-vt8vwo3y 51 18 4.8 4.8 CD cord-305859-vt8vwo3y 51 19 log log NN cord-305859-vt8vwo3y 51 20 10 10 CD cord-305859-vt8vwo3y 51 21 GE GE NNP cord-305859-vt8vwo3y 51 22 / / SYM cord-305859-vt8vwo3y 51 23 ml ml NNS cord-305859-vt8vwo3y 51 24 of of IN cord-305859-vt8vwo3y 51 25 PEDV PEDV NNP cord-305859-vt8vwo3y 51 26 in in IN cord-305859-vt8vwo3y 51 27 rectal rectal JJ cord-305859-vt8vwo3y 51 28 swab swab NN cord-305859-vt8vwo3y 51 29 samples sample NNS cord-305859-vt8vwo3y 51 30 [ [ -LRB- cord-305859-vt8vwo3y 51 31 6 6 CD cord-305859-vt8vwo3y 51 32 ] ] -RRB- cord-305859-vt8vwo3y 51 33 . . . cord-305859-vt8vwo3y 52 1 PDCoV pdcov JJ cord-305859-vt8vwo3y 52 2 OH OH NNP cord-305859-vt8vwo3y 52 3 - - HYPH cord-305859-vt8vwo3y 52 4 FD22-P5 FD22-P5 NNP cord-305859-vt8vwo3y 52 5 ( ( -LRB- cord-305859-vt8vwo3y 52 6 passage passage NN cord-305859-vt8vwo3y 52 7 five five CD cord-305859-vt8vwo3y 52 8 ) ) -RRB- cord-305859-vt8vwo3y 52 9 and and CC cord-305859-vt8vwo3y 53 1 PEDV PEDV NNP cord-305859-vt8vwo3y 53 2 PC22-P40 PC22-P40 NNP cord-305859-vt8vwo3y 53 3 ( ( -LRB- cord-305859-vt8vwo3y 53 4 passage passage NN cord-305859-vt8vwo3y 53 5 40 40 CD cord-305859-vt8vwo3y 53 6 ) ) -RRB- cord-305859-vt8vwo3y 53 7 viruses virus NNS cord-305859-vt8vwo3y 53 8 , , , cord-305859-vt8vwo3y 53 9 grown grow VBN cord-305859-vt8vwo3y 53 10 on on IN cord-305859-vt8vwo3y 53 11 LLC LLC NNP cord-305859-vt8vwo3y 53 12 - - HYPH cord-305859-vt8vwo3y 53 13 PK PK NNP cord-305859-vt8vwo3y 53 14 or or CC cord-305859-vt8vwo3y 53 15 Vero Vero NNP cord-305859-vt8vwo3y 53 16 cells cell NNS cord-305859-vt8vwo3y 53 17 , , , cord-305859-vt8vwo3y 53 18 respectively respectively RB cord-305859-vt8vwo3y 53 19 , , , cord-305859-vt8vwo3y 53 20 were be VBD cord-305859-vt8vwo3y 53 21 used use VBN cord-305859-vt8vwo3y 53 22 to to TO cord-305859-vt8vwo3y 53 23 infect infect VB cord-305859-vt8vwo3y 53 24 LLC LLC NNP cord-305859-vt8vwo3y 53 25 - - HYPH cord-305859-vt8vwo3y 53 26 PK PK NNP cord-305859-vt8vwo3y 53 27 or or CC cord-305859-vt8vwo3y 53 28 Vero Vero NNP cord-305859-vt8vwo3y 53 29 cells cell NNS cord-305859-vt8vwo3y 53 30 , , , cord-305859-vt8vwo3y 53 31 respectively respectively RB cord-305859-vt8vwo3y 53 32 , , , cord-305859-vt8vwo3y 53 33 in in IN cord-305859-vt8vwo3y 53 34 96-well 96-well CD cord-305859-vt8vwo3y 53 35 plates plate NNS cord-305859-vt8vwo3y 53 36 . . . cord-305859-vt8vwo3y 54 1 The the DT cord-305859-vt8vwo3y 54 2 viral viral JJ cord-305859-vt8vwo3y 54 3 antigens antigen NNS cord-305859-vt8vwo3y 54 4 expressed express VBN cord-305859-vt8vwo3y 54 5 were be VBD cord-305859-vt8vwo3y 54 6 detected detect VBN cord-305859-vt8vwo3y 54 7 by by IN cord-305859-vt8vwo3y 54 8 indirect indirect JJ cord-305859-vt8vwo3y 54 9 immunofluorescence immunofluorescence NN cord-305859-vt8vwo3y 54 10 assay assay NN cord-305859-vt8vwo3y 54 11 ( ( -LRB- cord-305859-vt8vwo3y 54 12 IFA IFA NNP cord-305859-vt8vwo3y 54 13 ) ) -RRB- cord-305859-vt8vwo3y 54 14 [ [ -LRB- cord-305859-vt8vwo3y 54 15 2 2 CD cord-305859-vt8vwo3y 54 16 , , , cord-305859-vt8vwo3y 54 17 3 3 CD cord-305859-vt8vwo3y 54 18 , , , cord-305859-vt8vwo3y 54 19 12 12 CD cord-305859-vt8vwo3y 54 20 ] ] -RRB- cord-305859-vt8vwo3y 54 21 . . . cord-305859-vt8vwo3y 55 1 A a DT cord-305859-vt8vwo3y 55 2 multiplicity multiplicity NN cord-305859-vt8vwo3y 55 3 of of IN cord-305859-vt8vwo3y 55 4 infection infection NN cord-305859-vt8vwo3y 55 5 of of IN cord-305859-vt8vwo3y 55 6 0.1 0.1 CD cord-305859-vt8vwo3y 55 7 was be VBD cord-305859-vt8vwo3y 55 8 used use VBN cord-305859-vt8vwo3y 55 9 for for IN cord-305859-vt8vwo3y 55 10 each each DT cord-305859-vt8vwo3y 55 11 viral viral JJ cord-305859-vt8vwo3y 55 12 inoculation inoculation NN cord-305859-vt8vwo3y 55 13 in in IN cord-305859-vt8vwo3y 55 14 LLC LLC NNP cord-305859-vt8vwo3y 55 15 - - HYPH cord-305859-vt8vwo3y 55 16 PK PK NNP cord-305859-vt8vwo3y 55 17 and and CC cord-305859-vt8vwo3y 55 18 Vero Vero NNP cord-305859-vt8vwo3y 55 19 cells cell NNS cord-305859-vt8vwo3y 55 20 treated treat VBN cord-305859-vt8vwo3y 55 21 with with IN cord-305859-vt8vwo3y 55 22 5 5 CD cord-305859-vt8vwo3y 55 23 and and CC cord-305859-vt8vwo3y 55 24 10 10 CD cord-305859-vt8vwo3y 55 25 lg lg NN cord-305859-vt8vwo3y 55 26 / / SYM cord-305859-vt8vwo3y 55 27 ml ml NN cord-305859-vt8vwo3y 55 28 of of IN cord-305859-vt8vwo3y 55 29 trypsin trypsin NN cord-305859-vt8vwo3y 55 30 , , , cord-305859-vt8vwo3y 55 31 respectively respectively RB cord-305859-vt8vwo3y 55 32 [ [ -LRB- cord-305859-vt8vwo3y 55 33 2 2 CD cord-305859-vt8vwo3y 55 34 , , , cord-305859-vt8vwo3y 55 35 3 3 CD cord-305859-vt8vwo3y 55 36 , , , cord-305859-vt8vwo3y 55 37 12 12 CD cord-305859-vt8vwo3y 55 38 ] ] -RRB- cord-305859-vt8vwo3y 55 39 . . . cord-305859-vt8vwo3y 56 1 The the DT cord-305859-vt8vwo3y 56 2 cell cell NN cord-305859-vt8vwo3y 56 3 culture culture NN cord-305859-vt8vwo3y 56 4 conditions condition NNS cord-305859-vt8vwo3y 56 5 used use VBN cord-305859-vt8vwo3y 56 6 to to TO cord-305859-vt8vwo3y 56 7 infect infect VB cord-305859-vt8vwo3y 56 8 LLC LLC NNP cord-305859-vt8vwo3y 56 9 - - HYPH cord-305859-vt8vwo3y 56 10 PK PK NNP cord-305859-vt8vwo3y 56 11 or or CC cord-305859-vt8vwo3y 56 12 Vero Vero NNP cord-305859-vt8vwo3y 56 13 cells cell NNS cord-305859-vt8vwo3y 56 14 with with IN cord-305859-vt8vwo3y 56 15 each each DT cord-305859-vt8vwo3y 56 16 virus virus NN cord-305859-vt8vwo3y 56 17 were be VBD cord-305859-vt8vwo3y 56 18 described describe VBN cord-305859-vt8vwo3y 56 19 previously previously RB cord-305859-vt8vwo3y 56 20 [ [ -LRB- cord-305859-vt8vwo3y 56 21 2 2 CD cord-305859-vt8vwo3y 56 22 , , , cord-305859-vt8vwo3y 56 23 3 3 CD cord-305859-vt8vwo3y 56 24 , , , cord-305859-vt8vwo3y 56 25 12 12 CD cord-305859-vt8vwo3y 56 26 ] ] -RRB- cord-305859-vt8vwo3y 56 27 . . . cord-305859-vt8vwo3y 57 1 Characteristic characteristic JJ cord-305859-vt8vwo3y 57 2 cytopathic cytopathic JJ cord-305859-vt8vwo3y 57 3 effects effect NNS cord-305859-vt8vwo3y 57 4 ( ( -LRB- cord-305859-vt8vwo3y 57 5 CPE CPE NNP cord-305859-vt8vwo3y 57 6 ) ) -RRB- cord-305859-vt8vwo3y 57 7 [ [ -LRB- cord-305859-vt8vwo3y 57 8 2 2 CD cord-305859-vt8vwo3y 57 9 , , , cord-305859-vt8vwo3y 57 10 3 3 CD cord-305859-vt8vwo3y 57 11 , , , cord-305859-vt8vwo3y 57 12 12 12 CD cord-305859-vt8vwo3y 57 13 ] ] -RRB- cord-305859-vt8vwo3y 57 14 were be VBD cord-305859-vt8vwo3y 57 15 monitored monitor VBN cord-305859-vt8vwo3y 57 16 regularly regularly RB cord-305859-vt8vwo3y 57 17 in in IN cord-305859-vt8vwo3y 57 18 inoculated inoculate VBN cord-305859-vt8vwo3y 57 19 LLC LLC NNP cord-305859-vt8vwo3y 57 20 - - HYPH cord-305859-vt8vwo3y 57 21 PK PK NNP cord-305859-vt8vwo3y 57 22 or or CC cord-305859-vt8vwo3y 57 23 Vero Vero NNP cord-305859-vt8vwo3y 57 24 cells cell NNS cord-305859-vt8vwo3y 57 25 . . . cord-305859-vt8vwo3y 58 1 When when WRB cord-305859-vt8vwo3y 58 2 CPE CPE NNP cord-305859-vt8vwo3y 58 3 was be VBD cord-305859-vt8vwo3y 58 4 pronounced pronounce VBN cord-305859-vt8vwo3y 58 5 , , , cord-305859-vt8vwo3y 58 6 PDCoV pdcov RB cord-305859-vt8vwo3y 58 7 - - HYPH cord-305859-vt8vwo3y 58 8 inoculated inoculate VBN cord-305859-vt8vwo3y 58 9 LLC LLC NNP cord-305859-vt8vwo3y 58 10 - - HYPH cord-305859-vt8vwo3y 58 11 PK PK NNP cord-305859-vt8vwo3y 58 12 ( ( -LRB- cord-305859-vt8vwo3y 58 13 PID PID NNP cord-305859-vt8vwo3y 58 14 1 1 CD cord-305859-vt8vwo3y 58 15 ) ) -RRB- cord-305859-vt8vwo3y 58 16 and and CC cord-305859-vt8vwo3y 58 17 PEDV PEDV NNP cord-305859-vt8vwo3y 58 18 - - HYPH cord-305859-vt8vwo3y 58 19 inoculated inoculate VBN cord-305859-vt8vwo3y 58 20 Vero Vero NNP cord-305859-vt8vwo3y 58 21 cells cell NNS cord-305859-vt8vwo3y 58 22 ( ( -LRB- cord-305859-vt8vwo3y 58 23 PID PID NNP cord-305859-vt8vwo3y 58 24 2 2 CD cord-305859-vt8vwo3y 58 25 ) ) -RRB- cord-305859-vt8vwo3y 58 26 were be VBD cord-305859-vt8vwo3y 58 27 fixed fix VBN cord-305859-vt8vwo3y 58 28 with with IN cord-305859-vt8vwo3y 58 29 100 100 CD cord-305859-vt8vwo3y 58 30 % % NN cord-305859-vt8vwo3y 58 31 ethanol ethanol NN cord-305859-vt8vwo3y 58 32 at at IN cord-305859-vt8vwo3y 58 33 4 4 CD cord-305859-vt8vwo3y 58 34 ° ° NN cord-305859-vt8vwo3y 58 35 C c NN cord-305859-vt8vwo3y 58 36 overnight overnight RB cord-305859-vt8vwo3y 58 37 for for IN cord-305859-vt8vwo3y 58 38 IFA IFA NNP cord-305859-vt8vwo3y 58 39 . . . cord-305859-vt8vwo3y 59 1 The the DT cord-305859-vt8vwo3y 59 2 fixed fix VBN cord-305859-vt8vwo3y 59 3 cells cell NNS cord-305859-vt8vwo3y 59 4 were be VBD cord-305859-vt8vwo3y 59 5 washed wash VBN cord-305859-vt8vwo3y 59 6 with with IN cord-305859-vt8vwo3y 59 7 0.01 0.01 CD cord-305859-vt8vwo3y 59 8 M m NN cord-305859-vt8vwo3y 59 9 phosphate phosphate NN cord-305859-vt8vwo3y 59 10 buffered buffer VBN cord-305859-vt8vwo3y 59 11 saline saline NN cord-305859-vt8vwo3y 59 12 ( ( -LRB- cord-305859-vt8vwo3y 59 13 PBS PBS NNP cord-305859-vt8vwo3y 59 14 ) ) -RRB- cord-305859-vt8vwo3y 59 15 ( ( -LRB- cord-305859-vt8vwo3y 59 16 pH pH NNP cord-305859-vt8vwo3y 59 17 7.4 7.4 CD cord-305859-vt8vwo3y 59 18 ) ) -RRB- cord-305859-vt8vwo3y 59 19 . . . cord-305859-vt8vwo3y 60 1 Blocking block VBG cord-305859-vt8vwo3y 60 2 was be VBD cord-305859-vt8vwo3y 60 3 performed perform VBN cord-305859-vt8vwo3y 60 4 with with IN cord-305859-vt8vwo3y 60 5 19 19 CD cord-305859-vt8vwo3y 60 6 buffered buffer VBN cord-305859-vt8vwo3y 60 7 solution solution NN cord-305859-vt8vwo3y 60 8 of of IN cord-305859-vt8vwo3y 60 9 casein casein NN cord-305859-vt8vwo3y 60 10 ( ( -LRB- cord-305859-vt8vwo3y 60 11 109 109 CD cord-305859-vt8vwo3y 60 12 Power Power NNP cord-305859-vt8vwo3y 60 13 Block Block NNP cord-305859-vt8vwo3y 60 14 TM TM NNP cord-305859-vt8vwo3y 60 15 Universal Universal NNP cord-305859-vt8vwo3y 60 16 Blocking Blocking NNP cord-305859-vt8vwo3y 60 17 Reagent Reagent NNP cord-305859-vt8vwo3y 60 18 , , , cord-305859-vt8vwo3y 60 19 Biogenx Biogenx NNP cord-305859-vt8vwo3y 60 20 , , , cord-305859-vt8vwo3y 60 21 CA CA NNP cord-305859-vt8vwo3y 60 22 , , , cord-305859-vt8vwo3y 60 23 USA USA NNP cord-305859-vt8vwo3y 60 24 ) ) -RRB- cord-305859-vt8vwo3y 60 25 in in IN cord-305859-vt8vwo3y 60 26 distilled distil VBN cord-305859-vt8vwo3y 60 27 water water NN cord-305859-vt8vwo3y 60 28 for for IN cord-305859-vt8vwo3y 60 29 1 1 CD cord-305859-vt8vwo3y 60 30 hr hr NN cord-305859-vt8vwo3y 60 31 at at IN cord-305859-vt8vwo3y 60 32 room room NN cord-305859-vt8vwo3y 60 33 temperature temperature NN cord-305859-vt8vwo3y 60 34 . . . cord-305859-vt8vwo3y 61 1 Four four CD cord-305859-vt8vwo3y 61 2 - - HYPH cord-305859-vt8vwo3y 61 3 fold fold JJ cord-305859-vt8vwo3y 61 4 serial serial JJ cord-305859-vt8vwo3y 61 5 dilutions dilution NNS cord-305859-vt8vwo3y 61 6 , , , cord-305859-vt8vwo3y 61 7 starting start VBG cord-305859-vt8vwo3y 61 8 at at IN cord-305859-vt8vwo3y 61 9 1:4 1:4 CD cord-305859-vt8vwo3y 61 10 , , , cord-305859-vt8vwo3y 61 11 of of IN cord-305859-vt8vwo3y 61 12 the the DT cord-305859-vt8vwo3y 61 13 paired pair VBN cord-305859-vt8vwo3y 61 14 serum serum NN cord-305859-vt8vwo3y 61 15 samples sample NNS cord-305859-vt8vwo3y 61 16 of of IN cord-305859-vt8vwo3y 61 17 calves calf NNS cord-305859-vt8vwo3y 61 18 # # $ cord-305859-vt8vwo3y 61 19 1 1 CD cord-305859-vt8vwo3y 61 20 and and CC cord-305859-vt8vwo3y 61 21 # # $ cord-305859-vt8vwo3y 61 22 5 5 CD cord-305859-vt8vwo3y 61 23 , , , cord-305859-vt8vwo3y 61 24 obtained obtain VBN cord-305859-vt8vwo3y 61 25 at at IN cord-305859-vt8vwo3y 61 26 PID PID NNP cord-305859-vt8vwo3y 61 27 0 0 NFP cord-305859-vt8vwo3y 61 28 and and CC cord-305859-vt8vwo3y 61 29 PID PID NNP cord-305859-vt8vwo3y 61 30 16 16 CD cord-305859-vt8vwo3y 61 31 - - SYM cord-305859-vt8vwo3y 61 32 17 17 CD cord-305859-vt8vwo3y 61 33 were be VBD cord-305859-vt8vwo3y 61 34 added add VBN cord-305859-vt8vwo3y 61 35 to to IN cord-305859-vt8vwo3y 61 36 the the DT cord-305859-vt8vwo3y 61 37 wells well NNS cord-305859-vt8vwo3y 61 38 and and CC cord-305859-vt8vwo3y 61 39 the the DT cord-305859-vt8vwo3y 61 40 plates plate NNS cord-305859-vt8vwo3y 61 41 were be VBD cord-305859-vt8vwo3y 61 42 incubated incubate VBN cord-305859-vt8vwo3y 61 43 overnight overnight RB cord-305859-vt8vwo3y 61 44 . . . cord-305859-vt8vwo3y 62 1 Swine Swine NNP cord-305859-vt8vwo3y 62 2 hyperimmune hyperimmune NNP cord-305859-vt8vwo3y 62 3 antiserum antiserum NN cord-305859-vt8vwo3y 62 4 against against IN cord-305859-vt8vwo3y 62 5 PDCoV PDCoV NNP cord-305859-vt8vwo3y 62 6 ( ( -LRB- cord-305859-vt8vwo3y 62 7 1:100 1:100 CD cord-305859-vt8vwo3y 62 8 ) ) -RRB- cord-305859-vt8vwo3y 62 9 or or CC cord-305859-vt8vwo3y 62 10 monoclonal monoclonal JJ cord-305859-vt8vwo3y 62 11 antibody antibody NN cord-305859-vt8vwo3y 62 12 against against IN cord-305859-vt8vwo3y 62 13 the the DT cord-305859-vt8vwo3y 62 14 spike spike NN cord-305859-vt8vwo3y 62 15 ( ( -LRB- cord-305859-vt8vwo3y 62 16 S s NN cord-305859-vt8vwo3y 62 17 ) ) -RRB- cord-305859-vt8vwo3y 62 18 protein protein NN cord-305859-vt8vwo3y 62 19 of of IN cord-305859-vt8vwo3y 62 20 PEDV PEDV NNP cord-305859-vt8vwo3y 62 21 ( ( -LRB- cord-305859-vt8vwo3y 62 22 6C8 6c8 CD cord-305859-vt8vwo3y 62 23 - - SYM cord-305859-vt8vwo3y 62 24 1 1 CD cord-305859-vt8vwo3y 62 25 ) ) -RRB- cord-305859-vt8vwo3y 62 26 ( ( -LRB- cord-305859-vt8vwo3y 62 27 1:200 1:200 LS cord-305859-vt8vwo3y 62 28 ) ) -RRB- cord-305859-vt8vwo3y 62 29 , , , cord-305859-vt8vwo3y 62 30 with with IN cord-305859-vt8vwo3y 62 31 the the DT cord-305859-vt8vwo3y 62 32 appropriate appropriate JJ cord-305859-vt8vwo3y 62 33 detection detection NN cord-305859-vt8vwo3y 62 34 antibodies antibody NNS cord-305859-vt8vwo3y 62 35 , , , cord-305859-vt8vwo3y 62 36 were be VBD cord-305859-vt8vwo3y 62 37 added add VBN cord-305859-vt8vwo3y 62 38 to to IN cord-305859-vt8vwo3y 62 39 the the DT cord-305859-vt8vwo3y 62 40 wells well NNS cord-305859-vt8vwo3y 62 41 as as IN cord-305859-vt8vwo3y 62 42 IFA IFA NNP cord-305859-vt8vwo3y 62 43 positive positive JJ cord-305859-vt8vwo3y 62 44 controls control NNS cord-305859-vt8vwo3y 62 45 [ [ -LRB- cord-305859-vt8vwo3y 62 46 2 2 CD cord-305859-vt8vwo3y 62 47 , , , cord-305859-vt8vwo3y 62 48 3 3 CD cord-305859-vt8vwo3y 62 49 , , , cord-305859-vt8vwo3y 62 50 12 12 CD cord-305859-vt8vwo3y 62 51 ] ] -RRB- cord-305859-vt8vwo3y 62 52 . . . cord-305859-vt8vwo3y 63 1 Goat Goat NNP cord-305859-vt8vwo3y 63 2 polyclonal polyclonal JJ cord-305859-vt8vwo3y 63 3 antibodies antibody NNS cord-305859-vt8vwo3y 63 4 specific specific JJ cord-305859-vt8vwo3y 63 5 for for IN cord-305859-vt8vwo3y 63 6 bovine bovine JJ cord-305859-vt8vwo3y 63 7 , , , cord-305859-vt8vwo3y 63 8 swine swine NN cord-305859-vt8vwo3y 63 9 or or CC cord-305859-vt8vwo3y 63 10 mouse mouse NN cord-305859-vt8vwo3y 63 11 IgG IgG NNP cord-305859-vt8vwo3y 63 12 ( ( -LRB- cord-305859-vt8vwo3y 63 13 whole whole JJ cord-305859-vt8vwo3y 63 14 IgG IgG NNP cord-305859-vt8vwo3y 63 15 ) ) -RRB- cord-305859-vt8vwo3y 63 16 conjugated conjugate VBN cord-305859-vt8vwo3y 63 17 to to IN cord-305859-vt8vwo3y 63 18 fluorescein fluorescein NN cord-305859-vt8vwo3y 63 19 ( ( -LRB- cord-305859-vt8vwo3y 63 20 KPL KPL NNP cord-305859-vt8vwo3y 63 21 , , , cord-305859-vt8vwo3y 63 22 Gaithersburg Gaithersburg NNP cord-305859-vt8vwo3y 63 23 , , , cord-305859-vt8vwo3y 63 24 MD MD NNP cord-305859-vt8vwo3y 63 25 , , , cord-305859-vt8vwo3y 63 26 USA USA NNP cord-305859-vt8vwo3y 63 27 ) ) -RRB- cord-305859-vt8vwo3y 63 28 were be VBD cord-305859-vt8vwo3y 63 29 diluted dilute VBN cord-305859-vt8vwo3y 63 30 1:100 1:100 CD cord-305859-vt8vwo3y 63 31 in in IN cord-305859-vt8vwo3y 63 32 0.01 0.01 CD cord-305859-vt8vwo3y 63 33 M M NNP cord-305859-vt8vwo3y 63 34 PBS PBS NNP cord-305859-vt8vwo3y 63 35 . . . cord-305859-vt8vwo3y 64 1 The the DT cord-305859-vt8vwo3y 64 2 plates plate NNS cord-305859-vt8vwo3y 64 3 were be VBD cord-305859-vt8vwo3y 64 4 incubated incubate VBN cord-305859-vt8vwo3y 64 5 for for IN cord-305859-vt8vwo3y 64 6 1 1 CD cord-305859-vt8vwo3y 64 7 hr hr NN cord-305859-vt8vwo3y 64 8 at at IN cord-305859-vt8vwo3y 64 9 37 37 CD cord-305859-vt8vwo3y 64 10 ° ° NN cord-305859-vt8vwo3y 64 11 C c NN cord-305859-vt8vwo3y 64 12 . . . cord-305859-vt8vwo3y 65 1 The the DT cord-305859-vt8vwo3y 65 2 stained stained JJ cord-305859-vt8vwo3y 65 3 plates plate NNS cord-305859-vt8vwo3y 65 4 were be VBD cord-305859-vt8vwo3y 65 5 evaluated evaluate VBN cord-305859-vt8vwo3y 65 6 using use VBG cord-305859-vt8vwo3y 65 7 a a DT cord-305859-vt8vwo3y 65 8 fluorescence fluorescence NN cord-305859-vt8vwo3y 65 9 microscope microscope NN cord-305859-vt8vwo3y 65 10 . . . cord-305859-vt8vwo3y 66 1 The the DT cord-305859-vt8vwo3y 66 2 antibody antibody NN cord-305859-vt8vwo3y 66 3 titers titer NNS cord-305859-vt8vwo3y 66 4 were be VBD cord-305859-vt8vwo3y 66 5 expressed express VBN cord-305859-vt8vwo3y 66 6 as as IN cord-305859-vt8vwo3y 66 7 the the DT cord-305859-vt8vwo3y 66 8 reciprocal reciprocal NN cord-305859-vt8vwo3y 66 9 of of IN cord-305859-vt8vwo3y 66 10 the the DT cord-305859-vt8vwo3y 66 11 highest high JJS cord-305859-vt8vwo3y 66 12 serum serum NN cord-305859-vt8vwo3y 66 13 dilution dilution NN cord-305859-vt8vwo3y 66 14 in in IN cord-305859-vt8vwo3y 66 15 the the DT cord-305859-vt8vwo3y 66 16 wells well NNS cord-305859-vt8vwo3y 66 17 that that WDT cord-305859-vt8vwo3y 66 18 were be VBD cord-305859-vt8vwo3y 66 19 positive positive JJ cord-305859-vt8vwo3y 66 20 for for IN cord-305859-vt8vwo3y 66 21 PDCoV pdcov NN cord-305859-vt8vwo3y 66 22 or or CC cord-305859-vt8vwo3y 66 23 PEDV PEDV NNP cord-305859-vt8vwo3y 66 24 antigen antigen NN cord-305859-vt8vwo3y 66 25 detection detection NN cord-305859-vt8vwo3y 66 26 . . . cord-305859-vt8vwo3y 67 1 Formalin Formalin NNP cord-305859-vt8vwo3y 67 2 - - HYPH cord-305859-vt8vwo3y 67 3 fixed fix VBN cord-305859-vt8vwo3y 67 4 or or CC cord-305859-vt8vwo3y 67 5 frozen freeze VBN cord-305859-vt8vwo3y 67 6 small small JJ cord-305859-vt8vwo3y 68 1 ( ( -LRB- cord-305859-vt8vwo3y 68 2 duodenum duodenum NN cord-305859-vt8vwo3y 68 3 , , , cord-305859-vt8vwo3y 68 4 jejunum jejunum NN cord-305859-vt8vwo3y 68 5 and and CC cord-305859-vt8vwo3y 68 6 ileum ileum NN cord-305859-vt8vwo3y 68 7 ) ) -RRB- cord-305859-vt8vwo3y 68 8 and and CC cord-305859-vt8vwo3y 68 9 large large JJ cord-305859-vt8vwo3y 68 10 ( ( -LRB- cord-305859-vt8vwo3y 68 11 cecum cecum NN cord-305859-vt8vwo3y 68 12 / / SYM cord-305859-vt8vwo3y 68 13 colon colon NN cord-305859-vt8vwo3y 68 14 ) ) -RRB- cord-305859-vt8vwo3y 68 15 intestinal intestinal JJ cord-305859-vt8vwo3y 68 16 tissues tissue NNS cord-305859-vt8vwo3y 68 17 and and CC cord-305859-vt8vwo3y 68 18 other other JJ cord-305859-vt8vwo3y 68 19 major major JJ cord-305859-vt8vwo3y 68 20 organs organ NNS cord-305859-vt8vwo3y 68 21 were be VBD cord-305859-vt8vwo3y 68 22 examined examine VBN cord-305859-vt8vwo3y 68 23 macroscopically macroscopically RB cord-305859-vt8vwo3y 68 24 and and CC cord-305859-vt8vwo3y 68 25 histologically histologically RB cord-305859-vt8vwo3y 68 26 and and CC cord-305859-vt8vwo3y 68 27 tested test VBN cord-305859-vt8vwo3y 68 28 by by IN cord-305859-vt8vwo3y 68 29 IF if NN cord-305859-vt8vwo3y 68 30 for for IN cord-305859-vt8vwo3y 68 31 PDCoV pdcov NN cord-305859-vt8vwo3y 68 32 or or CC cord-305859-vt8vwo3y 68 33 PEDV PEDV NNP cord-305859-vt8vwo3y 68 34 antigens antigen NNS cord-305859-vt8vwo3y 68 35 [ [ -LRB- cord-305859-vt8vwo3y 68 36 5 5 CD cord-305859-vt8vwo3y 68 37 , , , cord-305859-vt8vwo3y 68 38 6 6 CD cord-305859-vt8vwo3y 68 39 , , , cord-305859-vt8vwo3y 68 40 8 8 CD cord-305859-vt8vwo3y 68 41 ] ] -RRB- cord-305859-vt8vwo3y 68 42 . . . cord-305859-vt8vwo3y 69 1 Tissues tissue NNS cord-305859-vt8vwo3y 69 2 from from IN cord-305859-vt8vwo3y 69 3 the the DT cord-305859-vt8vwo3y 69 4 negative negative JJ cord-305859-vt8vwo3y 69 5 control control NN cord-305859-vt8vwo3y 69 6 calf calf NN cord-305859-vt8vwo3y 69 7 ( ( -LRB- cord-305859-vt8vwo3y 69 8 # # $ cord-305859-vt8vwo3y 69 9 8 8 CD cord-305859-vt8vwo3y 69 10 ) ) -RRB- cord-305859-vt8vwo3y 69 11 were be VBD cord-305859-vt8vwo3y 69 12 tested test VBN cord-305859-vt8vwo3y 69 13 for for IN cord-305859-vt8vwo3y 69 14 histological histological JJ cord-305859-vt8vwo3y 69 15 comparisons comparison NNS cord-305859-vt8vwo3y 69 16 and and CC cord-305859-vt8vwo3y 69 17 as as IN cord-305859-vt8vwo3y 69 18 an an DT cord-305859-vt8vwo3y 69 19 IF IF NNP cord-305859-vt8vwo3y 69 20 negative negative JJ cord-305859-vt8vwo3y 69 21 control control NN cord-305859-vt8vwo3y 69 22 . . . cord-305859-vt8vwo3y 70 1 Tissues tissue NNS cord-305859-vt8vwo3y 70 2 from from IN cord-305859-vt8vwo3y 70 3 PDCoV pdcov NN cord-305859-vt8vwo3y 70 4 - - : cord-305859-vt8vwo3y 70 5 or or CC cord-305859-vt8vwo3y 70 6 PEDV PEDV NNP cord-305859-vt8vwo3y 70 7 - - HYPH cord-305859-vt8vwo3y 70 8 infected infect VBN cord-305859-vt8vwo3y 70 9 Gn Gn NNP cord-305859-vt8vwo3y 70 10 pigs pig NNS cord-305859-vt8vwo3y 70 11 at at IN cord-305859-vt8vwo3y 70 12 PID PID NNP cord-305859-vt8vwo3y 70 13 3 3 CD cord-305859-vt8vwo3y 70 14 were be VBD cord-305859-vt8vwo3y 70 15 also also RB cord-305859-vt8vwo3y 70 16 tested test VBN cord-305859-vt8vwo3y 70 17 as as IN cord-305859-vt8vwo3y 70 18 positive positive JJ cord-305859-vt8vwo3y 70 19 controls control NNS cord-305859-vt8vwo3y 70 20 [ [ -LRB- cord-305859-vt8vwo3y 70 21 6 6 CD cord-305859-vt8vwo3y 70 22 , , , cord-305859-vt8vwo3y 70 23 8 8 CD cord-305859-vt8vwo3y 70 24 ] ] -RRB- cord-305859-vt8vwo3y 70 25 . . . cord-305859-vt8vwo3y 71 1 Clinical clinical JJ cord-305859-vt8vwo3y 71 2 observations observation NNS cord-305859-vt8vwo3y 71 3 revealed reveal VBD cord-305859-vt8vwo3y 71 4 that that IN cord-305859-vt8vwo3y 71 5 none none NN cord-305859-vt8vwo3y 71 6 of of IN cord-305859-vt8vwo3y 71 7 the the DT cord-305859-vt8vwo3y 71 8 Gn Gn NNP cord-305859-vt8vwo3y 71 9 calves calf NNS cord-305859-vt8vwo3y 71 10 inoculated inoculate VBN cord-305859-vt8vwo3y 71 11 with with IN cord-305859-vt8vwo3y 71 12 PDCoV pdcov JJ cord-305859-vt8vwo3y 71 13 ( ( -LRB- cord-305859-vt8vwo3y 71 14 calves calf NNS cord-305859-vt8vwo3y 71 15 # # $ cord-305859-vt8vwo3y 71 16 1 1 CD cord-305859-vt8vwo3y 71 17 - - SYM cord-305859-vt8vwo3y 71 18 4 4 CD cord-305859-vt8vwo3y 71 19 ) ) -RRB- cord-305859-vt8vwo3y 71 20 , , , cord-305859-vt8vwo3y 71 21 PEDV PEDV NNP cord-305859-vt8vwo3y 71 22 ( ( -LRB- cord-305859-vt8vwo3y 71 23 calves calf NNS cord-305859-vt8vwo3y 71 24 # # $ cord-305859-vt8vwo3y 71 25 5 5 CD cord-305859-vt8vwo3y 71 26 - - SYM cord-305859-vt8vwo3y 71 27 7 7 CD cord-305859-vt8vwo3y 71 28 ) ) -RRB- cord-305859-vt8vwo3y 71 29 , , , cord-305859-vt8vwo3y 71 30 or or CC cord-305859-vt8vwo3y 71 31 mock mock JJ cord-305859-vt8vwo3y 71 32 ( ( -LRB- cord-305859-vt8vwo3y 71 33 calf calf NN cord-305859-vt8vwo3y 71 34 # # NN cord-305859-vt8vwo3y 71 35 8) 8) NN cord-305859-vt8vwo3y 71 36 exhibited exhibit VBD cord-305859-vt8vwo3y 71 37 diarrhea diarrhea NN cord-305859-vt8vwo3y 71 38 or or CC cord-305859-vt8vwo3y 71 39 other other JJ cord-305859-vt8vwo3y 71 40 clinical clinical JJ cord-305859-vt8vwo3y 71 41 signs sign NNS cord-305859-vt8vwo3y 71 42 throughout throughout IN cord-305859-vt8vwo3y 71 43 the the DT cord-305859-vt8vwo3y 71 44 course course NN cord-305859-vt8vwo3y 71 45 of of IN cord-305859-vt8vwo3y 71 46 the the DT cord-305859-vt8vwo3y 71 47 experiment experiment NN cord-305859-vt8vwo3y 71 48 ( ( -LRB- cord-305859-vt8vwo3y 71 49 Fig Fig NNP cord-305859-vt8vwo3y 71 50 . . . cord-305859-vt8vwo3y 71 51 1 1 CD cord-305859-vt8vwo3y 71 52 ) ) -RRB- cord-305859-vt8vwo3y 71 53 . . . cord-305859-vt8vwo3y 72 1 PDCoV PDCoV NNP cord-305859-vt8vwo3y 72 2 RNA RNA NNP cord-305859-vt8vwo3y 72 3 was be VBD cord-305859-vt8vwo3y 72 4 first first RB cord-305859-vt8vwo3y 72 5 detected detect VBN cord-305859-vt8vwo3y 72 6 in in IN cord-305859-vt8vwo3y 72 7 fecal fecal JJ cord-305859-vt8vwo3y 72 8 samples sample NNS cord-305859-vt8vwo3y 72 9 at at IN cord-305859-vt8vwo3y 72 10 PID PID NNP cord-305859-vt8vwo3y 72 11 2 2 CD cord-305859-vt8vwo3y 72 12 ( ( -LRB- cord-305859-vt8vwo3y 72 13 calves calf NNS cord-305859-vt8vwo3y 72 14 # # $ cord-305859-vt8vwo3y 72 15 1 1 CD cord-305859-vt8vwo3y 72 16 and and CC cord-305859-vt8vwo3y 72 17 2 2 CD cord-305859-vt8vwo3y 72 18 ) ) -RRB- cord-305859-vt8vwo3y 72 19 or or CC cord-305859-vt8vwo3y 72 20 PID PID NNP cord-305859-vt8vwo3y 72 21 3 3 CD cord-305859-vt8vwo3y 73 1 ( ( -LRB- cord-305859-vt8vwo3y 73 2 calves calf NNS cord-305859-vt8vwo3y 73 3 # # $ cord-305859-vt8vwo3y 73 4 3 3 CD cord-305859-vt8vwo3y 73 5 and and CC cord-305859-vt8vwo3y 73 6 4 4 CD cord-305859-vt8vwo3y 73 7 ) ) -RRB- cord-305859-vt8vwo3y 73 8 by by IN cord-305859-vt8vwo3y 73 9 qRT qRT NNP cord-305859-vt8vwo3y 73 10 - - HYPH cord-305859-vt8vwo3y 73 11 PCR PCR NNP cord-305859-vt8vwo3y 73 12 ( ( -LRB- cord-305859-vt8vwo3y 73 13 Table Table NNP cord-305859-vt8vwo3y 73 14 1 1 CD cord-305859-vt8vwo3y 73 15 ) ) -RRB- cord-305859-vt8vwo3y 73 16 . . . cord-305859-vt8vwo3y 74 1 Fecal Fecal NNP cord-305859-vt8vwo3y 74 2 PDCoV pdcov NN cord-305859-vt8vwo3y 74 3 RNA RNA NNP cord-305859-vt8vwo3y 74 4 titers titer NNS cord-305859-vt8vwo3y 74 5 , , , cord-305859-vt8vwo3y 74 6 ranging range VBG cord-305859-vt8vwo3y 74 7 from from IN cord-305859-vt8vwo3y 74 8 7.2 7.2 CD cord-305859-vt8vwo3y 74 9 to to TO cord-305859-vt8vwo3y 74 10 8.4 8.4 CD cord-305859-vt8vwo3y 74 11 log log NN cord-305859-vt8vwo3y 74 12 10 10 CD cord-305859-vt8vwo3y 74 13 GE GE NNP cord-305859-vt8vwo3y 74 14 / / SYM cord-305859-vt8vwo3y 74 15 ml ml NNS cord-305859-vt8vwo3y 74 16 , , , cord-305859-vt8vwo3y 74 17 peaked peak VBD cord-305859-vt8vwo3y 74 18 at at IN cord-305859-vt8vwo3y 74 19 PID PID NNP cord-305859-vt8vwo3y 74 20 2 2 CD cord-305859-vt8vwo3y 74 21 ( ( -LRB- cord-305859-vt8vwo3y 74 22 calf calf NN cord-305859-vt8vwo3y 74 23 # # $ cord-305859-vt8vwo3y 74 24 2 2 CD cord-305859-vt8vwo3y 74 25 ) ) -RRB- cord-305859-vt8vwo3y 74 26 , , , cord-305859-vt8vwo3y 74 27 PID PID NNP cord-305859-vt8vwo3y 74 28 3 3 CD cord-305859-vt8vwo3y 74 29 ( ( -LRB- cord-305859-vt8vwo3y 74 30 calf calf NN cord-305859-vt8vwo3y 74 31 # # $ cord-305859-vt8vwo3y 74 32 1 1 CD cord-305859-vt8vwo3y 74 33 ) ) -RRB- cord-305859-vt8vwo3y 74 34 , , , cord-305859-vt8vwo3y 74 35 or or CC cord-305859-vt8vwo3y 74 36 PID PID NNP cord-305859-vt8vwo3y 74 37 4 4 CD cord-305859-vt8vwo3y 74 38 - - SYM cord-305859-vt8vwo3y 74 39 6 6 CD cord-305859-vt8vwo3y 74 40 ( ( -LRB- cord-305859-vt8vwo3y 74 41 calf calf NN cord-305859-vt8vwo3y 74 42 # # $ cord-305859-vt8vwo3y 74 43 3 3 CD cord-305859-vt8vwo3y 74 44 ) ) -RRB- cord-305859-vt8vwo3y 75 1 ( ( -LRB- cord-305859-vt8vwo3y 75 2 Table table NN cord-305859-vt8vwo3y 75 3 1 1 CD cord-305859-vt8vwo3y 75 4 ) ) -RRB- cord-305859-vt8vwo3y 75 5 . . . cord-305859-vt8vwo3y 76 1 Calf calf NN cord-305859-vt8vwo3y 76 2 # # NN cord-305859-vt8vwo3y 76 3 1 1 CD cord-305859-vt8vwo3y 76 4 , , , cord-305859-vt8vwo3y 76 5 was be VBD cord-305859-vt8vwo3y 76 6 followedup followedup JJ cord-305859-vt8vwo3y 76 7 long long JJ cord-305859-vt8vwo3y 76 8 - - HYPH cord-305859-vt8vwo3y 76 9 term term NN cord-305859-vt8vwo3y 76 10 and and CC cord-305859-vt8vwo3y 76 11 had have VBD cord-305859-vt8vwo3y 76 12 prolonged prolong VBN cord-305859-vt8vwo3y 76 13 viral viral JJ cord-305859-vt8vwo3y 76 14 RNA rna NN cord-305859-vt8vwo3y 76 15 shedding shed VBG cord-305859-vt8vwo3y 76 16 until until IN cord-305859-vt8vwo3y 76 17 PID PID NNP cord-305859-vt8vwo3y 76 18 16 16 CD cord-305859-vt8vwo3y 77 1 ( ( -LRB- cord-305859-vt8vwo3y 77 2 Fig Fig NNP cord-305859-vt8vwo3y 77 3 . . NNP cord-305859-vt8vwo3y 77 4 1 1 CD cord-305859-vt8vwo3y 77 5 ) ) -RRB- cord-305859-vt8vwo3y 77 6 . . . cord-305859-vt8vwo3y 78 1 The the DT cord-305859-vt8vwo3y 78 2 highest high JJS cord-305859-vt8vwo3y 78 3 fecal fecal JJ cord-305859-vt8vwo3y 78 4 PDCoV pdcov ADD cord-305859-vt8vwo3y 78 5 RNA RNA NNP cord-305859-vt8vwo3y 78 6 titer titer NN cord-305859-vt8vwo3y 78 7 of of IN cord-305859-vt8vwo3y 78 8 calf calf NN cord-305859-vt8vwo3y 78 9 # # $ cord-305859-vt8vwo3y 78 10 1 1 CD cord-305859-vt8vwo3y 78 11 was be VBD cord-305859-vt8vwo3y 78 12 at at IN cord-305859-vt8vwo3y 78 13 PID PID NNP cord-305859-vt8vwo3y 78 14 3 3 CD cord-305859-vt8vwo3y 78 15 ( ( -LRB- cord-305859-vt8vwo3y 78 16 8.4 8.4 CD cord-305859-vt8vwo3y 78 17 log log NN cord-305859-vt8vwo3y 78 18 10 10 CD cord-305859-vt8vwo3y 78 19 GE GE NNP cord-305859-vt8vwo3y 78 20 / / SYM cord-305859-vt8vwo3y 78 21 ml ml NNP cord-305859-vt8vwo3y 78 22 ) ) -RRB- cord-305859-vt8vwo3y 78 23 , , , cord-305859-vt8vwo3y 78 24 and and CC cord-305859-vt8vwo3y 78 25 the the DT cord-305859-vt8vwo3y 78 26 titers titer NNS cord-305859-vt8vwo3y 78 27 decreased decrease VBD cord-305859-vt8vwo3y 78 28 progressively progressively RB cord-305859-vt8vwo3y 78 29 thereafter thereafter RB cord-305859-vt8vwo3y 78 30 ( ( -LRB- cord-305859-vt8vwo3y 78 31 Fig fig NN cord-305859-vt8vwo3y 78 32 . . NNP cord-305859-vt8vwo3y 78 33 1 1 CD cord-305859-vt8vwo3y 78 34 ) ) -RRB- cord-305859-vt8vwo3y 78 35 . . . cord-305859-vt8vwo3y 79 1 On on IN cord-305859-vt8vwo3y 79 2 the the DT cord-305859-vt8vwo3y 79 3 other other JJ cord-305859-vt8vwo3y 79 4 hand hand NN cord-305859-vt8vwo3y 79 5 , , , cord-305859-vt8vwo3y 79 6 none none NN cord-305859-vt8vwo3y 79 7 of of IN cord-305859-vt8vwo3y 79 8 the the DT cord-305859-vt8vwo3y 79 9 Gn Gn NNP cord-305859-vt8vwo3y 79 10 calves calf NNS cord-305859-vt8vwo3y 79 11 inoculated inoculate VBN cord-305859-vt8vwo3y 79 12 with with IN cord-305859-vt8vwo3y 79 13 PEDV PEDV NNP cord-305859-vt8vwo3y 79 14 shed shed VBD cord-305859-vt8vwo3y 79 15 detectable detectable JJ cord-305859-vt8vwo3y 79 16 PEDV PEDV NNP cord-305859-vt8vwo3y 79 17 RNA RNA NNP cord-305859-vt8vwo3y 79 18 in in IN cord-305859-vt8vwo3y 79 19 the the DT cord-305859-vt8vwo3y 79 20 feces fece NNS cord-305859-vt8vwo3y 79 21 at at IN cord-305859-vt8vwo3y 79 22 PIDs PIDs NNP cord-305859-vt8vwo3y 79 23 1 1 CD cord-305859-vt8vwo3y 79 24 - - SYM cord-305859-vt8vwo3y 79 25 9 9 CD cord-305859-vt8vwo3y 79 26 ( ( -LRB- cord-305859-vt8vwo3y 79 27 calves calf NNS cord-305859-vt8vwo3y 79 28 # # $ cord-305859-vt8vwo3y 79 29 6 6 CD cord-305859-vt8vwo3y 79 30 and and CC cord-305859-vt8vwo3y 79 31 # # $ cord-305859-vt8vwo3y 79 32 7 7 CD cord-305859-vt8vwo3y 79 33 ) ) -RRB- cord-305859-vt8vwo3y 79 34 and and CC cord-305859-vt8vwo3y 79 35 PIDs PIDs NNP cord-305859-vt8vwo3y 79 36 1 1 CD cord-305859-vt8vwo3y 79 37 - - SYM cord-305859-vt8vwo3y 79 38 17 17 CD cord-305859-vt8vwo3y 79 39 ( ( -LRB- cord-305859-vt8vwo3y 79 40 calf calf NN cord-305859-vt8vwo3y 79 41 # # $ cord-305859-vt8vwo3y 79 42 5 5 CD cord-305859-vt8vwo3y 79 43 ) ) -RRB- cord-305859-vt8vwo3y 79 44 . . . cord-305859-vt8vwo3y 80 1 The the DT cord-305859-vt8vwo3y 80 2 negative negative JJ cord-305859-vt8vwo3y 80 3 control control NN cord-305859-vt8vwo3y 80 4 ( ( -LRB- cord-305859-vt8vwo3y 80 5 calf calf NN cord-305859-vt8vwo3y 80 6 # # NN cord-305859-vt8vwo3y 80 7 8) 8) NN cord-305859-vt8vwo3y 80 8 did do VBD cord-305859-vt8vwo3y 80 9 not not RB cord-305859-vt8vwo3y 80 10 shed shed VB cord-305859-vt8vwo3y 80 11 detectable detectable JJ cord-305859-vt8vwo3y 80 12 PDCoV pdcov DT cord-305859-vt8vwo3y 80 13 or or CC cord-305859-vt8vwo3y 80 14 PEDV PEDV NNP cord-305859-vt8vwo3y 80 15 RNA RNA NNP cord-305859-vt8vwo3y 80 16 in in IN cord-305859-vt8vwo3y 80 17 the the DT cord-305859-vt8vwo3y 80 18 feces fece NNS cord-305859-vt8vwo3y 80 19 during during IN cord-305859-vt8vwo3y 80 20 the the DT cord-305859-vt8vwo3y 80 21 experiment experiment NN cord-305859-vt8vwo3y 80 22 . . . cord-305859-vt8vwo3y 81 1 Nasal nasal NN cord-305859-vt8vwo3y 81 2 swab swab NN cord-305859-vt8vwo3y 81 3 or or CC cord-305859-vt8vwo3y 81 4 serum serum NN cord-305859-vt8vwo3y 81 5 samples sample NNS cord-305859-vt8vwo3y 81 6 collected collect VBN cord-305859-vt8vwo3y 81 7 from from IN cord-305859-vt8vwo3y 81 8 PDCoV pdcov RB cord-305859-vt8vwo3y 81 9 - - HYPH cord-305859-vt8vwo3y 81 10 inoculated inoculate VBN cord-305859-vt8vwo3y 81 11 calf calf NN cord-305859-vt8vwo3y 81 12 # # $ cord-305859-vt8vwo3y 81 13 1 1 CD cord-305859-vt8vwo3y 81 14 were be VBD cord-305859-vt8vwo3y 81 15 also also RB cord-305859-vt8vwo3y 81 16 tested test VBN cord-305859-vt8vwo3y 81 17 by by IN cord-305859-vt8vwo3y 81 18 qRT qRT NNP cord-305859-vt8vwo3y 81 19 - - HYPH cord-305859-vt8vwo3y 81 20 PCR PCR NNP cord-305859-vt8vwo3y 81 21 . . . cord-305859-vt8vwo3y 82 1 Serum serum NN cord-305859-vt8vwo3y 82 2 samples sample NNS cord-305859-vt8vwo3y 82 3 were be VBD cord-305859-vt8vwo3y 82 4 collected collect VBN cord-305859-vt8vwo3y 82 5 at at IN cord-305859-vt8vwo3y 82 6 PIDs pid NNS cord-305859-vt8vwo3y 82 7 3 3 CD cord-305859-vt8vwo3y 82 8 and and CC cord-305859-vt8vwo3y 82 9 15 15 CD cord-305859-vt8vwo3y 82 10 , , , cord-305859-vt8vwo3y 82 11 and and CC cord-305859-vt8vwo3y 82 12 nasal nasal NN cord-305859-vt8vwo3y 82 13 swab swab NN cord-305859-vt8vwo3y 82 14 samples sample NNS cord-305859-vt8vwo3y 82 15 were be VBD cord-305859-vt8vwo3y 82 16 collected collect VBN cord-305859-vt8vwo3y 82 17 at at IN cord-305859-vt8vwo3y 82 18 PIDs PIDs NNP cord-305859-vt8vwo3y 82 19 2 2 CD cord-305859-vt8vwo3y 82 20 , , , cord-305859-vt8vwo3y 82 21 6 6 CD cord-305859-vt8vwo3y 82 22 , , , cord-305859-vt8vwo3y 82 23 9 9 CD cord-305859-vt8vwo3y 82 24 , , , cord-305859-vt8vwo3y 82 25 13 13 CD cord-305859-vt8vwo3y 82 26 , , , cord-305859-vt8vwo3y 82 27 and and CC cord-305859-vt8vwo3y 82 28 16 16 CD cord-305859-vt8vwo3y 82 29 . . . cord-305859-vt8vwo3y 83 1 No no DT cord-305859-vt8vwo3y 83 2 PDCoV pdcov NN cord-305859-vt8vwo3y 83 3 RNA RNA NNP cord-305859-vt8vwo3y 83 4 was be VBD cord-305859-vt8vwo3y 83 5 detected detect VBN cord-305859-vt8vwo3y 83 6 in in IN cord-305859-vt8vwo3y 83 7 the the DT cord-305859-vt8vwo3y 83 8 serum serum NN cord-305859-vt8vwo3y 83 9 ( ( -LRB- cord-305859-vt8vwo3y 83 10 \3.6 \3.6 NNP cord-305859-vt8vwo3y 83 11 log log NN cord-305859-vt8vwo3y 83 12 10 10 CD cord-305859-vt8vwo3y 83 13 GE GE NNP cord-305859-vt8vwo3y 83 14 / / SYM cord-305859-vt8vwo3y 83 15 ml ml NN cord-305859-vt8vwo3y 83 16 ) ) -RRB- cord-305859-vt8vwo3y 83 17 and and CC cord-305859-vt8vwo3y 83 18 nasal nasal NN cord-305859-vt8vwo3y 83 19 swab swab NN cord-305859-vt8vwo3y 83 20 ( ( -LRB- cord-305859-vt8vwo3y 83 21 \5.3 \5.3 NN cord-305859-vt8vwo3y 83 22 log log NN cord-305859-vt8vwo3y 83 23 10 10 CD cord-305859-vt8vwo3y 83 24 GE GE NNP cord-305859-vt8vwo3y 83 25 / / SYM cord-305859-vt8vwo3y 83 26 ml ml NN cord-305859-vt8vwo3y 83 27 ) ) -RRB- cord-305859-vt8vwo3y 83 28 samples sample NNS cord-305859-vt8vwo3y 83 29 tested test VBN cord-305859-vt8vwo3y 83 30 at at IN cord-305859-vt8vwo3y 83 31 the the DT cord-305859-vt8vwo3y 83 32 time time NN cord-305859-vt8vwo3y 83 33 - - HYPH cord-305859-vt8vwo3y 83 34 points point NNS cord-305859-vt8vwo3y 83 35 indicated indicate VBN cord-305859-vt8vwo3y 83 36 . . . cord-305859-vt8vwo3y 84 1 IFA IFA NNP cord-305859-vt8vwo3y 84 2 showed show VBD cord-305859-vt8vwo3y 84 3 that that IN cord-305859-vt8vwo3y 84 4 calf calf NN cord-305859-vt8vwo3y 84 5 # # $ cord-305859-vt8vwo3y 84 6 1 1 CD cord-305859-vt8vwo3y 84 7 had have VBD cord-305859-vt8vwo3y 84 8 serum serum NN cord-305859-vt8vwo3y 84 9 IgG igg NN cord-305859-vt8vwo3y 84 10 antibodies antibody NNS cord-305859-vt8vwo3y 84 11 ( ( -LRB- cord-305859-vt8vwo3y 84 12 titer titer NN cord-305859-vt8vwo3y 84 13 of of IN cord-305859-vt8vwo3y 84 14 1,024 1,024 CD cord-305859-vt8vwo3y 84 15 ) ) -RRB- cord-305859-vt8vwo3y 84 16 against against IN cord-305859-vt8vwo3y 84 17 PDCoV PDCoV NNP cord-305859-vt8vwo3y 84 18 OH OH NNP cord-305859-vt8vwo3y 84 19 - - HYPH cord-305859-vt8vwo3y 84 20 FD22 FD22 NNP cord-305859-vt8vwo3y 84 21 at at IN cord-305859-vt8vwo3y 84 22 PID PID NNP cord-305859-vt8vwo3y 84 23 16 16 CD cord-305859-vt8vwo3y 84 24 , , , cord-305859-vt8vwo3y 84 25 indicating indicate VBG cord-305859-vt8vwo3y 84 26 seroconversion seroconversion NN cord-305859-vt8vwo3y 84 27 . . . cord-305859-vt8vwo3y 85 1 Large large JJ cord-305859-vt8vwo3y 85 2 numbers number NNS cord-305859-vt8vwo3y 85 3 of of IN cord-305859-vt8vwo3y 85 4 IF if NN cord-305859-vt8vwo3y 85 5 - - HYPH cord-305859-vt8vwo3y 85 6 stained stain VBN cord-305859-vt8vwo3y 85 7 cells cell NNS cord-305859-vt8vwo3y 85 8 were be VBD cord-305859-vt8vwo3y 85 9 consistently consistently RB cord-305859-vt8vwo3y 85 10 observed observe VBN cord-305859-vt8vwo3y 85 11 when when WRB cord-305859-vt8vwo3y 85 12 PDCoV pdcov RB cord-305859-vt8vwo3y 85 13 - - HYPH cord-305859-vt8vwo3y 85 14 infected infect VBN cord-305859-vt8vwo3y 85 15 LLC LLC NNP cord-305859-vt8vwo3y 85 16 - - HYPH cord-305859-vt8vwo3y 85 17 PK PK NNP cord-305859-vt8vwo3y 85 18 cells cell NNS cord-305859-vt8vwo3y 85 19 were be VBD cord-305859-vt8vwo3y 85 20 incubated incubate VBN cord-305859-vt8vwo3y 85 21 with with IN cord-305859-vt8vwo3y 85 22 the the DT cord-305859-vt8vwo3y 85 23 serum serum NN cord-305859-vt8vwo3y 85 24 diluted dilute VBD cord-305859-vt8vwo3y 85 25 1:4 1:4 CD cord-305859-vt8vwo3y 85 26 to to IN cord-305859-vt8vwo3y 85 27 1:1,024 1:1,024 CD cord-305859-vt8vwo3y 86 1 ( ( -LRB- cord-305859-vt8vwo3y 86 2 Fig Fig NNP cord-305859-vt8vwo3y 86 3 . . NNP cord-305859-vt8vwo3y 86 4 2 2 CD cord-305859-vt8vwo3y 86 5 ) ) -RRB- cord-305859-vt8vwo3y 86 6 . . . cord-305859-vt8vwo3y 87 1 No no DT cord-305859-vt8vwo3y 87 2 PDCoV pdcov RB cord-305859-vt8vwo3y 87 3 - - HYPH cord-305859-vt8vwo3y 87 4 specific specific JJ cord-305859-vt8vwo3y 87 5 IgG igg NN cord-305859-vt8vwo3y 87 6 antibodies antibody NNS cord-305859-vt8vwo3y 87 7 were be VBD cord-305859-vt8vwo3y 87 8 detected detect VBN cord-305859-vt8vwo3y 87 9 in in IN cord-305859-vt8vwo3y 87 10 the the DT cord-305859-vt8vwo3y 87 11 prebled prebled JJ cord-305859-vt8vwo3y 87 12 serum serum NN cord-305859-vt8vwo3y 87 13 samples sample NNS cord-305859-vt8vwo3y 87 14 of of IN cord-305859-vt8vwo3y 87 15 calf calf NN cord-305859-vt8vwo3y 87 16 # # $ cord-305859-vt8vwo3y 87 17 1 1 CD cord-305859-vt8vwo3y 87 18 and and CC cord-305859-vt8vwo3y 87 19 negative negative JJ cord-305859-vt8vwo3y 87 20 control control NN cord-305859-vt8vwo3y 87 21 calf calf NN cord-305859-vt8vwo3y 87 22 # # $ cord-305859-vt8vwo3y 87 23 8 8 CD cord-305859-vt8vwo3y 88 1 ( ( -LRB- cord-305859-vt8vwo3y 88 2 Fig Fig NNP cord-305859-vt8vwo3y 88 3 . . NNP cord-305859-vt8vwo3y 88 4 2 2 CD cord-305859-vt8vwo3y 88 5 ) ) -RRB- cord-305859-vt8vwo3y 88 6 . . . cord-305859-vt8vwo3y 89 1 In in IN cord-305859-vt8vwo3y 89 2 PEDV PEDV NNP cord-305859-vt8vwo3y 89 3 - - HYPH cord-305859-vt8vwo3y 89 4 inoculated inoculate VBN cord-305859-vt8vwo3y 89 5 calf calf NN cord-305859-vt8vwo3y 89 6 # # $ cord-305859-vt8vwo3y 89 7 5 5 CD cord-305859-vt8vwo3y 89 8 , , , cord-305859-vt8vwo3y 89 9 there there EX cord-305859-vt8vwo3y 89 10 were be VBD cord-305859-vt8vwo3y 89 11 no no DT cord-305859-vt8vwo3y 89 12 detectable detectable JJ cord-305859-vt8vwo3y 89 13 PEDV PEDV NNP cord-305859-vt8vwo3y 89 14 - - HYPH cord-305859-vt8vwo3y 89 15 specific specific JJ cord-305859-vt8vwo3y 89 16 IgG igg NN cord-305859-vt8vwo3y 89 17 antibodies antibody NNS cord-305859-vt8vwo3y 89 18 in in IN cord-305859-vt8vwo3y 89 19 the the DT cord-305859-vt8vwo3y 89 20 serum serum NN cord-305859-vt8vwo3y 89 21 samples sample NNS cord-305859-vt8vwo3y 89 22 at at IN cord-305859-vt8vwo3y 89 23 PID PID NNP cord-305859-vt8vwo3y 89 24 0 0 NFP cord-305859-vt8vwo3y 89 25 and and CC cord-305859-vt8vwo3y 89 26 PID PID NNP cord-305859-vt8vwo3y 89 27 17 17 CD cord-305859-vt8vwo3y 90 1 ( ( -LRB- cord-305859-vt8vwo3y 90 2 Fig Fig NNP cord-305859-vt8vwo3y 90 3 . . NNP cord-305859-vt8vwo3y 90 4 2 2 CD cord-305859-vt8vwo3y 90 5 ) ) -RRB- cord-305859-vt8vwo3y 90 6 . . . cord-305859-vt8vwo3y 91 1 Light light JJ cord-305859-vt8vwo3y 91 2 microscopy microscopy NN cord-305859-vt8vwo3y 91 3 analysis analysis NN cord-305859-vt8vwo3y 91 4 revealed reveal VBD cord-305859-vt8vwo3y 91 5 that that IN cord-305859-vt8vwo3y 91 6 none none NN cord-305859-vt8vwo3y 91 7 of of IN cord-305859-vt8vwo3y 91 8 the the DT cord-305859-vt8vwo3y 91 9 PDCoV pdcov NN cord-305859-vt8vwo3y 91 10 - - : cord-305859-vt8vwo3y 91 11 or or CC cord-305859-vt8vwo3y 91 12 PEDV PEDV NNP cord-305859-vt8vwo3y 91 13 - - HYPH cord-305859-vt8vwo3y 91 14 inoculated inoculate VBN cord-305859-vt8vwo3y 91 15 calves calf NNS cord-305859-vt8vwo3y 91 16 had have VBD cord-305859-vt8vwo3y 91 17 major major JJ cord-305859-vt8vwo3y 91 18 histological histological JJ cord-305859-vt8vwo3y 91 19 changes change NNS cord-305859-vt8vwo3y 91 20 in in IN cord-305859-vt8vwo3y 91 21 the the DT cord-305859-vt8vwo3y 91 22 intestine intestine NN cord-305859-vt8vwo3y 91 23 . . . cord-305859-vt8vwo3y 92 1 Additionally additionally RB cord-305859-vt8vwo3y 92 2 , , , cord-305859-vt8vwo3y 92 3 by by IN cord-305859-vt8vwo3y 92 4 IF if NN cord-305859-vt8vwo3y 92 5 , , , cord-305859-vt8vwo3y 92 6 no no UH cord-305859-vt8vwo3y 92 7 PDCoV pdcov XX cord-305859-vt8vwo3y 92 8 or or CC cord-305859-vt8vwo3y 92 9 PEDV PEDV NNP cord-305859-vt8vwo3y 92 10 antigen antigen NN cord-305859-vt8vwo3y 92 11 - - HYPH cord-305859-vt8vwo3y 92 12 positive positive JJ cord-305859-vt8vwo3y 92 13 cells cell NNS cord-305859-vt8vwo3y 92 14 were be VBD cord-305859-vt8vwo3y 92 15 observed observe VBN cord-305859-vt8vwo3y 92 16 in in IN cord-305859-vt8vwo3y 92 17 the the DT cord-305859-vt8vwo3y 92 18 small small JJ cord-305859-vt8vwo3y 92 19 and and CC cord-305859-vt8vwo3y 92 20 large large JJ cord-305859-vt8vwo3y 92 21 intestinal intestinal JJ cord-305859-vt8vwo3y 92 22 tissues tissue NNS cord-305859-vt8vwo3y 92 23 of of IN cord-305859-vt8vwo3y 92 24 PDCoV pdcov NN cord-305859-vt8vwo3y 92 25 or or CC cord-305859-vt8vwo3y 92 26 PEDV PEDV NNP cord-305859-vt8vwo3y 92 27 - - HYPH cord-305859-vt8vwo3y 92 28 inoculated inoculate VBN cord-305859-vt8vwo3y 92 29 Gn Gn NNP cord-305859-vt8vwo3y 92 30 calves calf NNS cord-305859-vt8vwo3y 92 31 , , , cord-305859-vt8vwo3y 92 32 while while IN cord-305859-vt8vwo3y 92 33 the the DT cord-305859-vt8vwo3y 92 34 intestinal intestinal JJ cord-305859-vt8vwo3y 92 35 tissues tissue NNS cord-305859-vt8vwo3y 92 36 ( ( -LRB- cord-305859-vt8vwo3y 92 37 mainly mainly RB cord-305859-vt8vwo3y 92 38 villous villous NNP cord-305859-vt8vwo3y 92 39 enterocytes enterocytes NNP cord-305859-vt8vwo3y 92 40 ) ) -RRB- cord-305859-vt8vwo3y 92 41 of of IN cord-305859-vt8vwo3y 92 42 PDCoV pdcov JJ cord-305859-vt8vwo3y 92 43 or or CC cord-305859-vt8vwo3y 92 44 PEDVinfected pedvinfecte VBN cord-305859-vt8vwo3y 92 45 Gn Gn NNP cord-305859-vt8vwo3y 92 46 pigs pig NNS cord-305859-vt8vwo3y 92 47 were be VBD cord-305859-vt8vwo3y 92 48 found find VBN cord-305859-vt8vwo3y 92 49 to to TO cord-305859-vt8vwo3y 92 50 be be VB cord-305859-vt8vwo3y 92 51 positive positive JJ cord-305859-vt8vwo3y 92 52 for for IN cord-305859-vt8vwo3y 92 53 PDCoV pdcov NN cord-305859-vt8vwo3y 92 54 or or CC cord-305859-vt8vwo3y 92 55 PEDV PEDV NNP cord-305859-vt8vwo3y 92 56 antigen antigen NN cord-305859-vt8vwo3y 92 57 in in IN cord-305859-vt8vwo3y 92 58 earlier early JJR cord-305859-vt8vwo3y 92 59 studies study NNS cord-305859-vt8vwo3y 92 60 [ [ -LRB- cord-305859-vt8vwo3y 92 61 6 6 CD cord-305859-vt8vwo3y 92 62 , , , cord-305859-vt8vwo3y 92 63 8 8 CD cord-305859-vt8vwo3y 92 64 ] ] -RRB- cord-305859-vt8vwo3y 92 65 . . . cord-305859-vt8vwo3y 93 1 Our -PRON- PRP$ cord-305859-vt8vwo3y 93 2 study study NN cord-305859-vt8vwo3y 93 3 demonstrated demonstrate VBD cord-305859-vt8vwo3y 93 4 that that IN cord-305859-vt8vwo3y 93 5 Gn Gn NNP cord-305859-vt8vwo3y 93 6 calves calf NNS cord-305859-vt8vwo3y 93 7 orally orally RB cord-305859-vt8vwo3y 93 8 inoculated inoculate VBD cord-305859-vt8vwo3y 93 9 with with IN cord-305859-vt8vwo3y 93 10 the the DT cord-305859-vt8vwo3y 93 11 PDCoV pdcov NN cord-305859-vt8vwo3y 93 12 strain strain NN cord-305859-vt8vwo3y 93 13 OH OH NNP cord-305859-vt8vwo3y 93 14 - - HYPH cord-305859-vt8vwo3y 93 15 FD22 FD22 NNP cord-305859-vt8vwo3y 93 16 ( ( -LRB- cord-305859-vt8vwo3y 93 17 ICs ics NN cord-305859-vt8vwo3y 93 18 of of IN cord-305859-vt8vwo3y 93 19 cell cell NN cord-305859-vt8vwo3y 93 20 - - HYPH cord-305859-vt8vwo3y 93 21 culture culture NN cord-305859-vt8vwo3y 93 22 grown grow VBN cord-305859-vt8vwo3y 93 23 PDCoV pdcov JJ cord-305859-vt8vwo3y 93 24 from from IN cord-305859-vt8vwo3y 93 25 infected infected JJ cord-305859-vt8vwo3y 93 26 Gn Gn NNP cord-305859-vt8vwo3y 93 27 pigs pig NNS cord-305859-vt8vwo3y 93 28 ) ) -RRB- cord-305859-vt8vwo3y 93 29 develop develop VB cord-305859-vt8vwo3y 93 30 an an DT cord-305859-vt8vwo3y 93 31 acute acute JJ cord-305859-vt8vwo3y 93 32 infection infection NN cord-305859-vt8vwo3y 93 33 with with IN cord-305859-vt8vwo3y 93 34 persistent persistent JJ cord-305859-vt8vwo3y 93 35 fecal fecal NN cord-305859-vt8vwo3y 93 36 PDCoV PDCoV NNP cord-305859-vt8vwo3y 93 37 RNA RNA NNP cord-305859-vt8vwo3y 93 38 shedding shed VBG cord-305859-vt8vwo3y 93 39 and and CC cord-305859-vt8vwo3y 93 40 PDCoVspecific PDCoVspecific NNP cord-305859-vt8vwo3y 93 41 serum serum NN cord-305859-vt8vwo3y 93 42 IgG IgG NNP cord-305859-vt8vwo3y 93 43 antibody antibody NN cord-305859-vt8vwo3y 93 44 responses response NNS cord-305859-vt8vwo3y 93 45 , , , cord-305859-vt8vwo3y 93 46 but but CC cord-305859-vt8vwo3y 93 47 show show VBP cord-305859-vt8vwo3y 93 48 no no DT cord-305859-vt8vwo3y 93 49 signs sign NNS cord-305859-vt8vwo3y 93 50 of of IN cord-305859-vt8vwo3y 93 51 significant significant JJ cord-305859-vt8vwo3y 93 52 intestinal intestinal JJ cord-305859-vt8vwo3y 93 53 lesions lesion NNS cord-305859-vt8vwo3y 93 54 or or CC cord-305859-vt8vwo3y 93 55 clinical clinical JJ cord-305859-vt8vwo3y 93 56 disease disease NN cord-305859-vt8vwo3y 93 57 [ [ -LRB- cord-305859-vt8vwo3y 93 58 8 8 CD cord-305859-vt8vwo3y 93 59 ] ] -RRB- cord-305859-vt8vwo3y 93 60 . . . cord-305859-vt8vwo3y 94 1 These these DT cord-305859-vt8vwo3y 94 2 observations observation NNS cord-305859-vt8vwo3y 94 3 are be VBP cord-305859-vt8vwo3y 94 4 similar similar JJ cord-305859-vt8vwo3y 94 5 to to IN cord-305859-vt8vwo3y 94 6 a a DT cord-305859-vt8vwo3y 94 7 previous previous JJ cord-305859-vt8vwo3y 94 8 report report NN cord-305859-vt8vwo3y 94 9 showing show VBG cord-305859-vt8vwo3y 94 10 that that IN cord-305859-vt8vwo3y 94 11 , , , cord-305859-vt8vwo3y 94 12 human human JJ cord-305859-vt8vwo3y 94 13 SARS SARS NNP cord-305859-vt8vwo3y 94 14 - - HYPH cord-305859-vt8vwo3y 94 15 CoV CoV NNP cord-305859-vt8vwo3y 94 16 strain strain NN cord-305859-vt8vwo3y 94 17 Urbani Urbani NNP cord-305859-vt8vwo3y 94 18 , , , cord-305859-vt8vwo3y 94 19 prior prior RB cord-305859-vt8vwo3y 94 20 to to IN cord-305859-vt8vwo3y 94 21 its -PRON- PRP$ cord-305859-vt8vwo3y 94 22 adaptation adaptation NN cord-305859-vt8vwo3y 94 23 to to IN cord-305859-vt8vwo3y 94 24 mice mouse NNS cord-305859-vt8vwo3y 94 25 ( ( -LRB- cord-305859-vt8vwo3y 94 26 MA105 MA105 NNP cord-305859-vt8vwo3y 94 27 strain strain NN cord-305859-vt8vwo3y 94 28 ) ) -RRB- cord-305859-vt8vwo3y 94 29 , , , cord-305859-vt8vwo3y 94 30 replicated replicate VBN cord-305859-vt8vwo3y 94 31 in in IN cord-305859-vt8vwo3y 94 32 the the DT cord-305859-vt8vwo3y 94 33 lungs lung NNS cord-305859-vt8vwo3y 94 34 of of IN cord-305859-vt8vwo3y 94 35 young young JJ cord-305859-vt8vwo3y 94 36 mice mouse NNS cord-305859-vt8vwo3y 94 37 , , , cord-305859-vt8vwo3y 94 38 as as IN cord-305859-vt8vwo3y 94 39 indicated indicate VBN cord-305859-vt8vwo3y 94 40 by by IN cord-305859-vt8vwo3y 94 41 their -PRON- PRP$ cord-305859-vt8vwo3y 94 42 lung lung NN cord-305859-vt8vwo3y 94 43 homogenates homogenate NNS cord-305859-vt8vwo3y 94 44 testing test VBG cord-305859-vt8vwo3y 94 45 positive positive JJ cord-305859-vt8vwo3y 94 46 by by IN cord-305859-vt8vwo3y 94 47 qRT qRT NNP cord-305859-vt8vwo3y 94 48 - - HYPH cord-305859-vt8vwo3y 94 49 PCR PCR NNP cord-305859-vt8vwo3y 94 50 . . . cord-305859-vt8vwo3y 95 1 However however RB cord-305859-vt8vwo3y 95 2 , , , cord-305859-vt8vwo3y 95 3 the the DT cord-305859-vt8vwo3y 95 4 Urbani Urbani NNP cord-305859-vt8vwo3y 95 5 strain strain NN cord-305859-vt8vwo3y 95 6 - - HYPH cord-305859-vt8vwo3y 95 7 inoculated inoculate VBN cord-305859-vt8vwo3y 95 8 mice mouse NNS cord-305859-vt8vwo3y 95 9 did do VBD cord-305859-vt8vwo3y 95 10 not not RB cord-305859-vt8vwo3y 95 11 show show VB cord-305859-vt8vwo3y 95 12 any any DT cord-305859-vt8vwo3y 95 13 clinical clinical JJ cord-305859-vt8vwo3y 95 14 signs sign NNS cord-305859-vt8vwo3y 95 15 , , , cord-305859-vt8vwo3y 95 16 but but CC cord-305859-vt8vwo3y 95 17 only only RB cord-305859-vt8vwo3y 95 18 mild mild JJ cord-305859-vt8vwo3y 95 19 histological histological JJ cord-305859-vt8vwo3y 95 20 lesions lesion NNS cord-305859-vt8vwo3y 95 21 with with IN cord-305859-vt8vwo3y 95 22 low low JJ cord-305859-vt8vwo3y 95 23 expression expression NN cord-305859-vt8vwo3y 95 24 of of IN cord-305859-vt8vwo3y 95 25 viral viral JJ cord-305859-vt8vwo3y 95 26 antigens antigen NNS cord-305859-vt8vwo3y 95 27 [ [ -LRB- cord-305859-vt8vwo3y 95 28 13 13 CD cord-305859-vt8vwo3y 95 29 ] ] -RRB- cord-305859-vt8vwo3y 95 30 . . . cord-305859-vt8vwo3y 96 1 In in IN cord-305859-vt8vwo3y 96 2 our -PRON- PRP$ cord-305859-vt8vwo3y 96 3 study study NN cord-305859-vt8vwo3y 96 4 , , , cord-305859-vt8vwo3y 96 5 there there EX cord-305859-vt8vwo3y 96 6 were be VBD cord-305859-vt8vwo3y 96 7 no no DT cord-305859-vt8vwo3y 96 8 detectable detectable JJ cord-305859-vt8vwo3y 96 9 fecal fecal JJ cord-305859-vt8vwo3y 96 10 viral viral JJ cord-305859-vt8vwo3y 96 11 RNA RNA NNP cord-305859-vt8vwo3y 96 12 shedding shedding NN cord-305859-vt8vwo3y 96 13 , , , cord-305859-vt8vwo3y 96 14 virus virus NN cord-305859-vt8vwo3y 96 15 - - HYPH cord-305859-vt8vwo3y 96 16 specific specific JJ cord-305859-vt8vwo3y 96 17 serum serum NN cord-305859-vt8vwo3y 96 18 IgG igg NN cord-305859-vt8vwo3y 96 19 antibody antibody NN cord-305859-vt8vwo3y 96 20 responses response NNS cord-305859-vt8vwo3y 96 21 , , , cord-305859-vt8vwo3y 96 22 histological histological JJ cord-305859-vt8vwo3y 96 23 lesions lesion NNS cord-305859-vt8vwo3y 96 24 , , , cord-305859-vt8vwo3y 96 25 and and CC cord-305859-vt8vwo3y 96 26 clinical clinical JJ cord-305859-vt8vwo3y 96 27 disease disease NN cord-305859-vt8vwo3y 96 28 in in IN cord-305859-vt8vwo3y 96 29 Gn Gn NNP cord-305859-vt8vwo3y 96 30 calves calf NNS cord-305859-vt8vwo3y 96 31 orally orally RB cord-305859-vt8vwo3y 96 32 inoculated inoculate VBD cord-305859-vt8vwo3y 96 33 with with IN cord-305859-vt8vwo3y 96 34 the the DT cord-305859-vt8vwo3y 96 35 PEDV PEDV NNP cord-305859-vt8vwo3y 96 36 strain strain NN cord-305859-vt8vwo3y 96 37 PC21A pc21a JJ cord-305859-vt8vwo3y 97 1 ( ( -LRB- cord-305859-vt8vwo3y 97 2 ICs ICs NNP cord-305859-vt8vwo3y 97 3 of of IN cord-305859-vt8vwo3y 97 4 wild wild JJ cord-305859-vt8vwo3y 97 5 - - HYPH cord-305859-vt8vwo3y 97 6 type type NN cord-305859-vt8vwo3y 97 7 PEDV PEDV NNP cord-305859-vt8vwo3y 97 8 - - HYPH cord-305859-vt8vwo3y 97 9 infected infect VBN cord-305859-vt8vwo3y 97 10 Gn Gn NNP cord-305859-vt8vwo3y 97 11 pigs pig NNS cord-305859-vt8vwo3y 97 12 ) ) -RRB- cord-305859-vt8vwo3y 97 13 [ [ -LRB- cord-305859-vt8vwo3y 97 14 6 6 CD cord-305859-vt8vwo3y 97 15 ] ] -RRB- cord-305859-vt8vwo3y 97 16 . . . cord-305859-vt8vwo3y 98 1 For for IN cord-305859-vt8vwo3y 98 2 the the DT cord-305859-vt8vwo3y 98 3 past past JJ cord-305859-vt8vwo3y 98 4 40 40 CD cord-305859-vt8vwo3y 98 5 years year NNS cord-305859-vt8vwo3y 98 6 , , , cord-305859-vt8vwo3y 98 7 PEDV PEDV NNP cord-305859-vt8vwo3y 98 8 has have VBZ cord-305859-vt8vwo3y 98 9 been be VBN cord-305859-vt8vwo3y 98 10 found find VBN cord-305859-vt8vwo3y 98 11 only only RB cord-305859-vt8vwo3y 98 12 within within IN cord-305859-vt8vwo3y 98 13 pigs pig NNS cord-305859-vt8vwo3y 98 14 , , , cord-305859-vt8vwo3y 98 15 indicating indicate VBG cord-305859-vt8vwo3y 98 16 that that IN cord-305859-vt8vwo3y 98 17 PEDV PEDV NNP cord-305859-vt8vwo3y 98 18 may may MD cord-305859-vt8vwo3y 98 19 have have VB cord-305859-vt8vwo3y 98 20 only only RB cord-305859-vt8vwo3y 98 21 adapted adapt VBN cord-305859-vt8vwo3y 98 22 to to IN cord-305859-vt8vwo3y 98 23 pigs pig NNS cord-305859-vt8vwo3y 98 24 [ [ -LRB- cord-305859-vt8vwo3y 98 25 9 9 CD cord-305859-vt8vwo3y 98 26 ] ] -RRB- cord-305859-vt8vwo3y 98 27 . . . cord-305859-vt8vwo3y 99 1 In in IN cord-305859-vt8vwo3y 99 2 contrast contrast NN cord-305859-vt8vwo3y 99 3 , , , cord-305859-vt8vwo3y 99 4 PDCoV pdcov ADD cord-305859-vt8vwo3y 99 5 may may MD cord-305859-vt8vwo3y 99 6 not not RB cord-305859-vt8vwo3y 99 7 yet yet RB cord-305859-vt8vwo3y 99 8 be be VB cord-305859-vt8vwo3y 99 9 completely completely RB cord-305859-vt8vwo3y 99 10 adapted adapt VBN cord-305859-vt8vwo3y 99 11 to to IN cord-305859-vt8vwo3y 99 12 pigs pig NNS cord-305859-vt8vwo3y 99 13 , , , cord-305859-vt8vwo3y 99 14 and and CC cord-305859-vt8vwo3y 99 15 the the DT cord-305859-vt8vwo3y 99 16 disease disease NN cord-305859-vt8vwo3y 99 17 caused cause VBN cord-305859-vt8vwo3y 99 18 by by IN cord-305859-vt8vwo3y 99 19 PDCoV PDCoV NNP cord-305859-vt8vwo3y 99 20 has have VBZ cord-305859-vt8vwo3y 99 21 emerged emerge VBN cord-305859-vt8vwo3y 99 22 only only RB cord-305859-vt8vwo3y 99 23 2 2 CD cord-305859-vt8vwo3y 99 24 - - SYM cord-305859-vt8vwo3y 99 25 3 3 CD cord-305859-vt8vwo3y 99 26 years year NNS cord-305859-vt8vwo3y 99 27 ago ago RB cord-305859-vt8vwo3y 99 28 . . . cord-305859-vt8vwo3y 100 1 PDCoV pdcov RB cord-305859-vt8vwo3y 100 2 - - HYPH cord-305859-vt8vwo3y 100 3 infected infect VBN cord-305859-vt8vwo3y 100 4 pigs pig NNS cord-305859-vt8vwo3y 100 5 appeared appear VBD cord-305859-vt8vwo3y 100 6 to to TO cord-305859-vt8vwo3y 100 7 shed shed VB cord-305859-vt8vwo3y 100 8 less less JJR cord-305859-vt8vwo3y 100 9 PDCoV pdcov JJ cord-305859-vt8vwo3y 100 10 RNA RNA NNP cord-305859-vt8vwo3y 100 11 and and CC cord-305859-vt8vwo3y 100 12 had have VBD cord-305859-vt8vwo3y 100 13 a a DT cord-305859-vt8vwo3y 100 14 lower low JJR cord-305859-vt8vwo3y 100 15 peak peak NN cord-305859-vt8vwo3y 100 16 of of IN cord-305859-vt8vwo3y 100 17 viral viral JJ cord-305859-vt8vwo3y 100 18 titer titer NN cord-305859-vt8vwo3y 100 19 in in IN cord-305859-vt8vwo3y 100 20 the the DT cord-305859-vt8vwo3y 100 21 feces fece NNS cord-305859-vt8vwo3y 100 22 , , , cord-305859-vt8vwo3y 100 23 compared compare VBN cord-305859-vt8vwo3y 100 24 with with IN cord-305859-vt8vwo3y 100 25 experimental experimental JJ cord-305859-vt8vwo3y 100 26 PEDV PEDV NNP cord-305859-vt8vwo3y 100 27 infections infection NNS cord-305859-vt8vwo3y 100 28 [ [ -LRB- cord-305859-vt8vwo3y 100 29 7 7 CD cord-305859-vt8vwo3y 100 30 , , , cord-305859-vt8vwo3y 100 31 11 11 CD cord-305859-vt8vwo3y 100 32 ] ] -RRB- cord-305859-vt8vwo3y 100 33 , , , cord-305859-vt8vwo3y 100 34 suggesting suggest VBG cord-305859-vt8vwo3y 100 35 that that IN cord-305859-vt8vwo3y 100 36 there there EX cord-305859-vt8vwo3y 100 37 is be VBZ cord-305859-vt8vwo3y 100 38 a a DT cord-305859-vt8vwo3y 100 39 lower low JJR cord-305859-vt8vwo3y 100 40 replication replication NN cord-305859-vt8vwo3y 100 41 of of IN cord-305859-vt8vwo3y 100 42 PDCoV pdcov NN cord-305859-vt8vwo3y 100 43 in in IN cord-305859-vt8vwo3y 100 44 the the DT cord-305859-vt8vwo3y 100 45 intestine intestine NN cord-305859-vt8vwo3y 100 46 of of IN cord-305859-vt8vwo3y 100 47 pigs pig NNS cord-305859-vt8vwo3y 100 48 , , , cord-305859-vt8vwo3y 100 49 possibly possibly RB cord-305859-vt8vwo3y 100 50 due due IN cord-305859-vt8vwo3y 100 51 to to IN cord-305859-vt8vwo3y 100 52 its -PRON- PRP$ cord-305859-vt8vwo3y 100 53 incomplete incomplete JJ cord-305859-vt8vwo3y 100 54 adaptation adaptation NN cord-305859-vt8vwo3y 100 55 to to IN cord-305859-vt8vwo3y 100 56 pigs pig NNS cord-305859-vt8vwo3y 100 57 . . . cord-305859-vt8vwo3y 101 1 In in IN cord-305859-vt8vwo3y 101 2 a a DT cord-305859-vt8vwo3y 101 3 molecular molecular JJ cord-305859-vt8vwo3y 101 4 surveillance surveillance NN cord-305859-vt8vwo3y 101 5 study study NN cord-305859-vt8vwo3y 101 6 in in IN cord-305859-vt8vwo3y 101 7 China China NNP cord-305859-vt8vwo3y 101 8 and and CC cord-305859-vt8vwo3y 101 9 Hong Hong NNP cord-305859-vt8vwo3y 101 10 Kong Kong NNP cord-305859-vt8vwo3y 101 11 conducted conduct VBN cord-305859-vt8vwo3y 101 12 in in IN cord-305859-vt8vwo3y 101 13 2007 2007 CD cord-305859-vt8vwo3y 101 14 - - SYM cord-305859-vt8vwo3y 101 15 2011 2011 CD cord-305859-vt8vwo3y 101 16 , , , cord-305859-vt8vwo3y 101 17 deltacoronaviruses deltacoronaviruse NNS cord-305859-vt8vwo3y 101 18 ( ( -LRB- cord-305859-vt8vwo3y 101 19 DCoVs DCoVs NNP cord-305859-vt8vwo3y 101 20 ) ) -RRB- cord-305859-vt8vwo3y 101 21 were be VBD cord-305859-vt8vwo3y 101 22 detected detect VBN cord-305859-vt8vwo3y 101 23 only only RB cord-305859-vt8vwo3y 101 24 in in IN cord-305859-vt8vwo3y 101 25 pigs pig NNS cord-305859-vt8vwo3y 101 26 and and CC cord-305859-vt8vwo3y 101 27 wild wild JJ cord-305859-vt8vwo3y 101 28 birds bird NNS cord-305859-vt8vwo3y 101 29 [ [ -LRB- cord-305859-vt8vwo3y 101 30 18 18 CD cord-305859-vt8vwo3y 101 31 ] ] -RRB- cord-305859-vt8vwo3y 101 32 . . . cord-305859-vt8vwo3y 102 1 However however RB cord-305859-vt8vwo3y 102 2 , , , cord-305859-vt8vwo3y 102 3 DCoVs DCoVs NNP cord-305859-vt8vwo3y 102 4 were be VBD cord-305859-vt8vwo3y 102 5 detected detect VBN cord-305859-vt8vwo3y 102 6 previously previously RB cord-305859-vt8vwo3y 102 7 in in IN cord-305859-vt8vwo3y 102 8 rectal rectal JJ cord-305859-vt8vwo3y 102 9 swabs swab NNS cord-305859-vt8vwo3y 102 10 of of IN cord-305859-vt8vwo3y 102 11 small small JJ cord-305859-vt8vwo3y 102 12 mammals mammal NNS cord-305859-vt8vwo3y 102 13 , , , cord-305859-vt8vwo3y 102 14 such such JJ cord-305859-vt8vwo3y 102 15 as as IN cord-305859-vt8vwo3y 102 16 Asian asian JJ cord-305859-vt8vwo3y 102 17 leopard leopard NN cord-305859-vt8vwo3y 102 18 cats cat NNS cord-305859-vt8vwo3y 102 19 and and CC cord-305859-vt8vwo3y 102 20 Chinese chinese JJ cord-305859-vt8vwo3y 102 21 ferret ferret JJ cord-305859-vt8vwo3y 102 22 badgers badger NNS cord-305859-vt8vwo3y 102 23 , , , cord-305859-vt8vwo3y 102 24 in in IN cord-305859-vt8vwo3y 102 25 live live JJ cord-305859-vt8vwo3y 102 26 - - HYPH cord-305859-vt8vwo3y 102 27 animal animal NN cord-305859-vt8vwo3y 102 28 markets market NNS cord-305859-vt8vwo3y 102 29 in in IN cord-305859-vt8vwo3y 102 30 China China NNP cord-305859-vt8vwo3y 102 31 , , , cord-305859-vt8vwo3y 102 32 in in IN cord-305859-vt8vwo3y 102 33 2005 2005 CD cord-305859-vt8vwo3y 102 34 - - SYM cord-305859-vt8vwo3y 102 35 2006 2006 CD cord-305859-vt8vwo3y 102 36 [ [ -LRB- cord-305859-vt8vwo3y 102 37 1 1 CD cord-305859-vt8vwo3y 102 38 ] ] -RRB- cord-305859-vt8vwo3y 102 39 . . . cord-305859-vt8vwo3y 103 1 The the DT cord-305859-vt8vwo3y 103 2 helicase helicase NN cord-305859-vt8vwo3y 103 3 and and CC cord-305859-vt8vwo3y 103 4 S S NNP cord-305859-vt8vwo3y 103 5 genes gene NNS cord-305859-vt8vwo3y 103 6 of of IN cord-305859-vt8vwo3y 103 7 the the DT cord-305859-vt8vwo3y 103 8 CoVs CoVs NNP cord-305859-vt8vwo3y 103 9 isolated isolate VBN cord-305859-vt8vwo3y 103 10 from from IN cord-305859-vt8vwo3y 103 11 the the DT cord-305859-vt8vwo3y 103 12 wild wild JJ cord-305859-vt8vwo3y 103 13 small small JJ cord-305859-vt8vwo3y 103 14 mammals mammal NNS cord-305859-vt8vwo3y 103 15 were be VBD cord-305859-vt8vwo3y 103 16 closely closely RB cord-305859-vt8vwo3y 103 17 related related JJ cord-305859-vt8vwo3y 103 18 to to IN cord-305859-vt8vwo3y 103 19 those those DT cord-305859-vt8vwo3y 103 20 of of IN cord-305859-vt8vwo3y 103 21 PDCoV pdcov JJ cord-305859-vt8vwo3y 103 22 [ [ -LRB- cord-305859-vt8vwo3y 103 23 18 18 CD cord-305859-vt8vwo3y 103 24 ] ] -RRB- cord-305859-vt8vwo3y 103 25 , , , cord-305859-vt8vwo3y 103 26 suggesting suggest VBG cord-305859-vt8vwo3y 103 27 that that IN cord-305859-vt8vwo3y 103 28 a a DT cord-305859-vt8vwo3y 103 29 potential potential JJ cord-305859-vt8vwo3y 103 30 interspecies interspecies NN cord-305859-vt8vwo3y 103 31 transmission transmission NN cord-305859-vt8vwo3y 103 32 event event NN cord-305859-vt8vwo3y 103 33 may may MD cord-305859-vt8vwo3y 103 34 have have VB cord-305859-vt8vwo3y 103 35 occurred occur VBN cord-305859-vt8vwo3y 103 36 leading lead VBG cord-305859-vt8vwo3y 103 37 to to IN cord-305859-vt8vwo3y 103 38 DCoV dcov JJ cord-305859-vt8vwo3y 103 39 transmission transmission NN cord-305859-vt8vwo3y 103 40 between between IN cord-305859-vt8vwo3y 103 41 wild wild JJ cord-305859-vt8vwo3y 103 42 small small JJ cord-305859-vt8vwo3y 103 43 mammals mammal NNS cord-305859-vt8vwo3y 103 44 and and CC cord-305859-vt8vwo3y 103 45 pigs pig NNS cord-305859-vt8vwo3y 103 46 . . . cord-305859-vt8vwo3y 104 1 However however RB cord-305859-vt8vwo3y 104 2 , , , cord-305859-vt8vwo3y 104 3 further further JJ cord-305859-vt8vwo3y 104 4 studies study NNS cord-305859-vt8vwo3y 104 5 are be VBP cord-305859-vt8vwo3y 104 6 needed need VBN cord-305859-vt8vwo3y 104 7 to to TO cord-305859-vt8vwo3y 104 8 define define VB cord-305859-vt8vwo3y 104 9 the the DT cord-305859-vt8vwo3y 104 10 potential potential JJ cord-305859-vt8vwo3y 104 11 role role NN cord-305859-vt8vwo3y 104 12 of of IN cord-305859-vt8vwo3y 104 13 small small JJ cord-305859-vt8vwo3y 104 14 mammals mammal NNS cord-305859-vt8vwo3y 104 15 as as IN cord-305859-vt8vwo3y 104 16 an an DT cord-305859-vt8vwo3y 104 17 intermediate intermediate JJ cord-305859-vt8vwo3y 104 18 host host NN cord-305859-vt8vwo3y 104 19 of of IN cord-305859-vt8vwo3y 104 20 PDCoV pdcov NN cord-305859-vt8vwo3y 104 21 and and CC cord-305859-vt8vwo3y 104 22 the the DT cord-305859-vt8vwo3y 104 23 mechanisms mechanism NNS cord-305859-vt8vwo3y 104 24 of of IN cord-305859-vt8vwo3y 104 25 interspecies interspecie NNS cord-305859-vt8vwo3y 104 26 transmission transmission NN cord-305859-vt8vwo3y 104 27 of of IN cord-305859-vt8vwo3y 104 28 DCoVs dcovs CD cord-305859-vt8vwo3y 104 29 between between IN cord-305859-vt8vwo3y 104 30 small small JJ cord-305859-vt8vwo3y 104 31 mammals mammal NNS cord-305859-vt8vwo3y 104 32 and and CC cord-305859-vt8vwo3y 104 33 domestic domestic JJ cord-305859-vt8vwo3y 104 34 pigs pig NNS cord-305859-vt8vwo3y 104 35 or or CC cord-305859-vt8vwo3y 104 36 wild wild JJ cord-305859-vt8vwo3y 104 37 birds bird NNS cord-305859-vt8vwo3y 104 38 . . . cord-305859-vt8vwo3y 105 1 Our -PRON- PRP$ cord-305859-vt8vwo3y 105 2 data datum NNS cord-305859-vt8vwo3y 105 3 also also RB cord-305859-vt8vwo3y 105 4 support support VBP cord-305859-vt8vwo3y 105 5 the the DT cord-305859-vt8vwo3y 105 6 Fig Fig NNP cord-305859-vt8vwo3y 105 7 . . . cord-305859-vt8vwo3y 105 8 1 1 CD cord-305859-vt8vwo3y 105 9 Persisting persist VBG cord-305859-vt8vwo3y 105 10 fecal fecal JJ cord-305859-vt8vwo3y 105 11 viral viral JJ cord-305859-vt8vwo3y 105 12 RNA RNA NNP cord-305859-vt8vwo3y 105 13 shedding shed VBG cord-305859-vt8vwo3y 105 14 of of IN cord-305859-vt8vwo3y 105 15 calf calf NN cord-305859-vt8vwo3y 105 16 # # $ cord-305859-vt8vwo3y 105 17 1 1 CD cord-305859-vt8vwo3y 105 18 inoculated inoculate VBN cord-305859-vt8vwo3y 105 19 with with IN cord-305859-vt8vwo3y 105 20 PDCoV pdcov NN cord-305859-vt8vwo3y 105 21 strain strain NN cord-305859-vt8vwo3y 105 22 OH OH NNP cord-305859-vt8vwo3y 105 23 - - HYPH cord-305859-vt8vwo3y 105 24 FD22-P5 FD22-P5 NNP cord-305859-vt8vwo3y 105 25 , , , cord-305859-vt8vwo3y 105 26 but but CC cord-305859-vt8vwo3y 105 27 without without IN cord-305859-vt8vwo3y 105 28 diarrhea diarrhea NN cord-305859-vt8vwo3y 105 29 . . . cord-305859-vt8vwo3y 106 1 Calf calf NN cord-305859-vt8vwo3y 106 2 # # NN cord-305859-vt8vwo3y 106 3 1 1 CD cord-305859-vt8vwo3y 106 4 was be VBD cord-305859-vt8vwo3y 106 5 inoculated inoculate VBN cord-305859-vt8vwo3y 106 6 orally orally RB cord-305859-vt8vwo3y 106 7 with with IN cord-305859-vt8vwo3y 106 8 9.6 9.6 CD cord-305859-vt8vwo3y 106 9 log log NN cord-305859-vt8vwo3y 106 10 10 10 CD cord-305859-vt8vwo3y 106 11 GE GE NNP cord-305859-vt8vwo3y 106 12 of of IN cord-305859-vt8vwo3y 106 13 the the DT cord-305859-vt8vwo3y 106 14 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 106 15 pig pig NN cord-305859-vt8vwo3y 106 16 - - HYPH cord-305859-vt8vwo3y 106 17 passaged passage VBN cord-305859-vt8vwo3y 106 18 OH OH NNP cord-305859-vt8vwo3y 106 19 - - HYPH cord-305859-vt8vwo3y 106 20 FD22-P5 FD22-P5 NNP cord-305859-vt8vwo3y 106 21 . . . cord-305859-vt8vwo3y 107 1 It -PRON- PRP cord-305859-vt8vwo3y 107 2 was be VBD cord-305859-vt8vwo3y 107 3 monitored monitor VBN cord-305859-vt8vwo3y 107 4 for for IN cord-305859-vt8vwo3y 107 5 long long JJ cord-305859-vt8vwo3y 107 6 - - HYPH cord-305859-vt8vwo3y 107 7 term term NN cord-305859-vt8vwo3y 107 8 clinical clinical JJ cord-305859-vt8vwo3y 107 9 signs sign NNS cord-305859-vt8vwo3y 107 10 and and CC cord-305859-vt8vwo3y 107 11 virus virus NN cord-305859-vt8vwo3y 107 12 shedding shed VBG cord-305859-vt8vwo3y 107 13 at at IN cord-305859-vt8vwo3y 107 14 PIDs pid NNS cord-305859-vt8vwo3y 107 15 1 1 CD cord-305859-vt8vwo3y 107 16 to to IN cord-305859-vt8vwo3y 107 17 16 16 CD cord-305859-vt8vwo3y 107 18 . . . cord-305859-vt8vwo3y 108 1 Rectal rectal JJ cord-305859-vt8vwo3y 108 2 swabs swab NNS cord-305859-vt8vwo3y 108 3 were be VBD cord-305859-vt8vwo3y 108 4 collected collect VBN cord-305859-vt8vwo3y 108 5 daily daily RB cord-305859-vt8vwo3y 108 6 throughout throughout IN cord-305859-vt8vwo3y 108 7 the the DT cord-305859-vt8vwo3y 108 8 experiment experiment NN cord-305859-vt8vwo3y 108 9 . . . cord-305859-vt8vwo3y 109 1 The the DT cord-305859-vt8vwo3y 109 2 PDCoV pdcov NN cord-305859-vt8vwo3y 109 3 fecal fecal JJ cord-305859-vt8vwo3y 109 4 shedding shed VBG cord-305859-vt8vwo3y 109 5 titers titer NNS cord-305859-vt8vwo3y 109 6 were be VBD cord-305859-vt8vwo3y 109 7 determined determine VBN cord-305859-vt8vwo3y 109 8 by by IN cord-305859-vt8vwo3y 109 9 qRT qRT NNP cord-305859-vt8vwo3y 109 10 - - HYPH cord-305859-vt8vwo3y 109 11 PCR PCR NNP cord-305859-vt8vwo3y 109 12 . . . cord-305859-vt8vwo3y 110 1 The the DT cord-305859-vt8vwo3y 110 2 dotted dotted JJ cord-305859-vt8vwo3y 110 3 line line NN cord-305859-vt8vwo3y 110 4 indicates indicate VBZ cord-305859-vt8vwo3y 110 5 the the DT cord-305859-vt8vwo3y 110 6 detection detection NN cord-305859-vt8vwo3y 110 7 limit limit NN cord-305859-vt8vwo3y 110 8 ( ( -LRB- cord-305859-vt8vwo3y 110 9 4.6 4.6 CD cord-305859-vt8vwo3y 110 10 log log NN cord-305859-vt8vwo3y 110 11 10 10 CD cord-305859-vt8vwo3y 110 12 GE GE NNP cord-305859-vt8vwo3y 110 13 / / SYM cord-305859-vt8vwo3y 110 14 ml ml NN cord-305859-vt8vwo3y 110 15 ) ) -RRB- cord-305859-vt8vwo3y 110 16 of of IN cord-305859-vt8vwo3y 110 17 the the DT cord-305859-vt8vwo3y 110 18 qRT qRT NNP cord-305859-vt8vwo3y 110 19 - - HYPH cord-305859-vt8vwo3y 110 20 PCR PCR NNP cord-305859-vt8vwo3y 110 21 potential potential JJ cord-305859-vt8vwo3y 110 22 ability ability NN cord-305859-vt8vwo3y 110 23 of of IN cord-305859-vt8vwo3y 110 24 the the DT cord-305859-vt8vwo3y 110 25 newly newly RB cord-305859-vt8vwo3y 110 26 emerged emerge VBN cord-305859-vt8vwo3y 110 27 PDCoV pdcov JJ cord-305859-vt8vwo3y 110 28 to to TO cord-305859-vt8vwo3y 110 29 infect infect VB cord-305859-vt8vwo3y 110 30 another another DT cord-305859-vt8vwo3y 110 31 animal animal NN cord-305859-vt8vwo3y 110 32 species specie NNS cord-305859-vt8vwo3y 110 33 , , , cord-305859-vt8vwo3y 110 34 such such JJ cord-305859-vt8vwo3y 110 35 as as IN cord-305859-vt8vwo3y 110 36 cattle cattle NNS cord-305859-vt8vwo3y 110 37 [ [ -LRB- cord-305859-vt8vwo3y 110 38 16 16 CD cord-305859-vt8vwo3y 110 39 ] ] -RRB- cord-305859-vt8vwo3y 110 40 . . . cord-305859-vt8vwo3y 111 1 However however RB cord-305859-vt8vwo3y 111 2 , , , cord-305859-vt8vwo3y 111 3 our -PRON- PRP$ cord-305859-vt8vwo3y 111 4 study study NN cord-305859-vt8vwo3y 111 5 did do VBD cord-305859-vt8vwo3y 111 6 not not RB cord-305859-vt8vwo3y 111 7 demonstrate demonstrate VB cord-305859-vt8vwo3y 111 8 PDCoV PDCoV NNP cord-305859-vt8vwo3y 111 9 's 's POS cord-305859-vt8vwo3y 111 10 ability ability NN cord-305859-vt8vwo3y 111 11 of of IN cord-305859-vt8vwo3y 111 12 direct direct JJ cord-305859-vt8vwo3y 111 13 interspecies interspecies NN cord-305859-vt8vwo3y 111 14 transmission transmission NN cord-305859-vt8vwo3y 111 15 between between IN cord-305859-vt8vwo3y 111 16 pigs pig NNS cord-305859-vt8vwo3y 111 17 and and CC cord-305859-vt8vwo3y 111 18 cattle cattle NNS cord-305859-vt8vwo3y 111 19 . . . cord-305859-vt8vwo3y 112 1 The the DT cord-305859-vt8vwo3y 112 2 S S NNP cord-305859-vt8vwo3y 112 3 protein protein NN cord-305859-vt8vwo3y 112 4 of of IN cord-305859-vt8vwo3y 112 5 CoVs CoVs NNP cord-305859-vt8vwo3y 112 6 is be VBZ cord-305859-vt8vwo3y 112 7 critical critical JJ cord-305859-vt8vwo3y 112 8 for for IN cord-305859-vt8vwo3y 112 9 regulating regulate VBG cord-305859-vt8vwo3y 112 10 interactions interaction NNS cord-305859-vt8vwo3y 112 11 with with IN cord-305859-vt8vwo3y 112 12 specific specific JJ cord-305859-vt8vwo3y 112 13 host host NN cord-305859-vt8vwo3y 112 14 cell cell NN cord-305859-vt8vwo3y 112 15 receptor receptor NN cord-305859-vt8vwo3y 112 16 glycoproteins glycoprotein NNS cord-305859-vt8vwo3y 112 17 to to TO cord-305859-vt8vwo3y 112 18 mediate mediate VB cord-305859-vt8vwo3y 112 19 viral viral JJ cord-305859-vt8vwo3y 112 20 entry entry NN cord-305859-vt8vwo3y 112 21 [ [ -LRB- cord-305859-vt8vwo3y 112 22 15 15 CD cord-305859-vt8vwo3y 112 23 ] ] -RRB- cord-305859-vt8vwo3y 112 24 . . . cord-305859-vt8vwo3y 113 1 Based base VBN cord-305859-vt8vwo3y 113 2 on on IN cord-305859-vt8vwo3y 113 3 our -PRON- PRP$ cord-305859-vt8vwo3y 113 4 data datum NNS cord-305859-vt8vwo3y 113 5 , , , cord-305859-vt8vwo3y 113 6 it -PRON- PRP cord-305859-vt8vwo3y 113 7 is be VBZ cord-305859-vt8vwo3y 113 8 possible possible JJ cord-305859-vt8vwo3y 113 9 that that IN cord-305859-vt8vwo3y 113 10 interactions interaction NNS cord-305859-vt8vwo3y 113 11 between between IN cord-305859-vt8vwo3y 113 12 PDCoV pdcov NN cord-305859-vt8vwo3y 113 13 S s NN cord-305859-vt8vwo3y 113 14 protein protein NN cord-305859-vt8vwo3y 113 15 and and CC cord-305859-vt8vwo3y 113 16 the the DT cord-305859-vt8vwo3y 113 17 host host NN cord-305859-vt8vwo3y 113 18 cell cell NN cord-305859-vt8vwo3y 113 19 receptor receptor NN cord-305859-vt8vwo3y 113 20 or or CC cord-305859-vt8vwo3y 113 21 co co JJ cord-305859-vt8vwo3y 113 22 - - NN cord-305859-vt8vwo3y 113 23 receptor receptor JJ cord-305859-vt8vwo3y 113 24 binding binding NN cord-305859-vt8vwo3y 113 25 may may MD cord-305859-vt8vwo3y 113 26 occur occur VB cord-305859-vt8vwo3y 113 27 in in IN cord-305859-vt8vwo3y 113 28 the the DT cord-305859-vt8vwo3y 113 29 bovine bovine JJ cord-305859-vt8vwo3y 113 30 intestine intestine NN cord-305859-vt8vwo3y 113 31 , , , cord-305859-vt8vwo3y 113 32 whereas whereas IN cord-305859-vt8vwo3y 113 33 this this DT cord-305859-vt8vwo3y 113 34 may may MD cord-305859-vt8vwo3y 113 35 not not RB cord-305859-vt8vwo3y 113 36 be be VB cord-305859-vt8vwo3y 113 37 the the DT cord-305859-vt8vwo3y 113 38 case case NN cord-305859-vt8vwo3y 113 39 for for IN cord-305859-vt8vwo3y 113 40 PEDV PEDV NNP cord-305859-vt8vwo3y 113 41 S S NNP cord-305859-vt8vwo3y 113 42 protein protein NN cord-305859-vt8vwo3y 113 43 . . . cord-305859-vt8vwo3y 114 1 The the DT cord-305859-vt8vwo3y 114 2 major major JJ cord-305859-vt8vwo3y 114 3 cellular cellular JJ cord-305859-vt8vwo3y 114 4 receptors receptor NNS cord-305859-vt8vwo3y 114 5 of of IN cord-305859-vt8vwo3y 114 6 PEDV PEDV NNP cord-305859-vt8vwo3y 114 7 and and CC cord-305859-vt8vwo3y 114 8 PDCoV pdcov JJ cord-305859-vt8vwo3y 114 9 in in IN cord-305859-vt8vwo3y 114 10 pigs pig NNS cord-305859-vt8vwo3y 114 11 are be VBP cord-305859-vt8vwo3y 114 12 unknown unknown JJ cord-305859-vt8vwo3y 114 13 [ [ -LRB- cord-305859-vt8vwo3y 114 14 10 10 CD cord-305859-vt8vwo3y 114 15 , , , cord-305859-vt8vwo3y 114 16 14 14 CD cord-305859-vt8vwo3y 114 17 ] ] -RRB- cord-305859-vt8vwo3y 114 18 . . . cord-305859-vt8vwo3y 115 1 The the DT cord-305859-vt8vwo3y 115 2 CoV cov NN cord-305859-vt8vwo3y 115 3 S s NN cord-305859-vt8vwo3y 115 4 proteins protein NNS cord-305859-vt8vwo3y 115 5 can can MD cord-305859-vt8vwo3y 115 6 be be VB cord-305859-vt8vwo3y 115 7 divided divide VBN cord-305859-vt8vwo3y 115 8 into into IN cord-305859-vt8vwo3y 115 9 two two CD cord-305859-vt8vwo3y 115 10 functional functional JJ cord-305859-vt8vwo3y 115 11 subunits subunit NNS cord-305859-vt8vwo3y 115 12 , , , cord-305859-vt8vwo3y 115 13 S1 S1 NNP cord-305859-vt8vwo3y 115 14 and and CC cord-305859-vt8vwo3y 115 15 S2 S2 NNP cord-305859-vt8vwo3y 115 16 . . . cord-305859-vt8vwo3y 116 1 The the DT cord-305859-vt8vwo3y 116 2 S1 s1 NN cord-305859-vt8vwo3y 116 3 is be VBZ cord-305859-vt8vwo3y 116 4 involved involve VBN cord-305859-vt8vwo3y 116 5 in in IN cord-305859-vt8vwo3y 116 6 the the DT cord-305859-vt8vwo3y 116 7 receptor receptor NN cord-305859-vt8vwo3y 116 8 recognition recognition NN cord-305859-vt8vwo3y 116 9 and and CC cord-305859-vt8vwo3y 116 10 binding bind VBG cord-305859-vt8vwo3y 116 11 via via IN cord-305859-vt8vwo3y 116 12 the the DT cord-305859-vt8vwo3y 116 13 N n CD cord-305859-vt8vwo3y 116 14 - - HYPH cord-305859-vt8vwo3y 116 15 terminal terminal NN cord-305859-vt8vwo3y 116 16 or or CC cord-305859-vt8vwo3y 116 17 C c NN cord-305859-vt8vwo3y 116 18 - - HYPH cord-305859-vt8vwo3y 116 19 terminal terminal NN cord-305859-vt8vwo3y 116 20 virus virus NN cord-305859-vt8vwo3y 116 21 receptor receptor NN cord-305859-vt8vwo3y 116 22 binding bind VBG cord-305859-vt8vwo3y 116 23 domains domain NNS cord-305859-vt8vwo3y 116 24 . . . cord-305859-vt8vwo3y 117 1 Therefore therefore RB cord-305859-vt8vwo3y 117 2 , , , cord-305859-vt8vwo3y 117 3 proteolysis proteolysis NN cord-305859-vt8vwo3y 117 4 between between IN cord-305859-vt8vwo3y 117 5 S1 S1 NNP cord-305859-vt8vwo3y 117 6 and and CC cord-305859-vt8vwo3y 117 7 S2 S2 NNP cord-305859-vt8vwo3y 117 8 is be VBZ cord-305859-vt8vwo3y 117 9 a a DT cord-305859-vt8vwo3y 117 10 critical critical JJ cord-305859-vt8vwo3y 117 11 determinant determinant NN cord-305859-vt8vwo3y 117 12 for for IN cord-305859-vt8vwo3y 117 13 CoV cov NN cord-305859-vt8vwo3y 117 14 tropism tropism NN cord-305859-vt8vwo3y 117 15 and and CC cord-305859-vt8vwo3y 117 16 pathogenesis pathogenesis NN cord-305859-vt8vwo3y 117 17 . . . cord-305859-vt8vwo3y 118 1 The the DT cord-305859-vt8vwo3y 118 2 CoV cov NN cord-305859-vt8vwo3y 118 3 S s NN cord-305859-vt8vwo3y 118 4 proteins protein NNS cord-305859-vt8vwo3y 118 5 can can MD cord-305859-vt8vwo3y 118 6 be be VB cord-305859-vt8vwo3y 118 7 cleaved cleave VBN cord-305859-vt8vwo3y 118 8 by by IN cord-305859-vt8vwo3y 118 9 different different JJ cord-305859-vt8vwo3y 118 10 animal animal NN cord-305859-vt8vwo3y 118 11 proteases protease NNS cord-305859-vt8vwo3y 118 12 [ [ -LRB- cord-305859-vt8vwo3y 118 13 15 15 CD cord-305859-vt8vwo3y 118 14 ] ] -RRB- cord-305859-vt8vwo3y 118 15 . . . cord-305859-vt8vwo3y 119 1 The the DT cord-305859-vt8vwo3y 119 2 extent extent NN cord-305859-vt8vwo3y 119 3 of of IN cord-305859-vt8vwo3y 119 4 cleavage cleavage NN cord-305859-vt8vwo3y 119 5 of of IN cord-305859-vt8vwo3y 119 6 PEDV PEDV NNP cord-305859-vt8vwo3y 119 7 and and CC cord-305859-vt8vwo3y 119 8 PDCoV PDCoV NNP cord-305859-vt8vwo3y 119 9 S s NN cord-305859-vt8vwo3y 119 10 proteins protein NNS cord-305859-vt8vwo3y 119 11 might may MD cord-305859-vt8vwo3y 119 12 differ differ VB cord-305859-vt8vwo3y 119 13 in in IN cord-305859-vt8vwo3y 119 14 the the DT cord-305859-vt8vwo3y 119 15 bovine bovine JJ cord-305859-vt8vwo3y 119 16 intestine intestine NN cord-305859-vt8vwo3y 119 17 , , , cord-305859-vt8vwo3y 119 18 possibly possibly RB cord-305859-vt8vwo3y 119 19 depending depend VBG cord-305859-vt8vwo3y 119 20 on on IN cord-305859-vt8vwo3y 119 21 their -PRON- PRP$ cord-305859-vt8vwo3y 119 22 adaptation adaptation NN cord-305859-vt8vwo3y 119 23 to to IN cord-305859-vt8vwo3y 119 24 the the DT cord-305859-vt8vwo3y 119 25 bovine bovine JJ cord-305859-vt8vwo3y 119 26 intestinal intestinal JJ cord-305859-vt8vwo3y 119 27 environment environment NN cord-305859-vt8vwo3y 119 28 ; ; : cord-305859-vt8vwo3y 119 29 for for IN cord-305859-vt8vwo3y 119 30 example example NN cord-305859-vt8vwo3y 119 31 , , , cord-305859-vt8vwo3y 119 32 exogenous exogenous JJ cord-305859-vt8vwo3y 119 33 proteolytic proteolytic JJ cord-305859-vt8vwo3y 119 34 enzymes enzyme NNS cord-305859-vt8vwo3y 119 35 of of IN cord-305859-vt8vwo3y 119 36 bovine bovine JJ cord-305859-vt8vwo3y 119 37 origin origin NN cord-305859-vt8vwo3y 119 38 may may MD cord-305859-vt8vwo3y 119 39 influence influence VB cord-305859-vt8vwo3y 119 40 PEDV PEDV NNP cord-305859-vt8vwo3y 119 41 or or CC cord-305859-vt8vwo3y 119 42 PDCoV pdcov NN cord-305859-vt8vwo3y 119 43 S s NN cord-305859-vt8vwo3y 119 44 proteinhost proteinhost NN cord-305859-vt8vwo3y 119 45 cell cell NN cord-305859-vt8vwo3y 119 46 receptor receptor NN cord-305859-vt8vwo3y 119 47 binding binding NN cord-305859-vt8vwo3y 119 48 . . . cord-305859-vt8vwo3y 120 1 However however RB cord-305859-vt8vwo3y 120 2 , , , cord-305859-vt8vwo3y 120 3 these these DT cord-305859-vt8vwo3y 120 4 assumptions assumption NNS cord-305859-vt8vwo3y 120 5 should should MD cord-305859-vt8vwo3y 120 6 be be VB cord-305859-vt8vwo3y 120 7 verified verify VBN cord-305859-vt8vwo3y 120 8 by by IN cord-305859-vt8vwo3y 120 9 further further JJ cord-305859-vt8vwo3y 120 10 studies study NNS cord-305859-vt8vwo3y 120 11 . . . cord-305859-vt8vwo3y 121 1 In in IN cord-305859-vt8vwo3y 121 2 our -PRON- PRP$ cord-305859-vt8vwo3y 121 3 study study NN cord-305859-vt8vwo3y 121 4 , , , cord-305859-vt8vwo3y 121 5 PDCoV pdcov RB cord-305859-vt8vwo3y 121 6 - - HYPH cord-305859-vt8vwo3y 121 7 inoculated inoculate VBN cord-305859-vt8vwo3y 121 8 calves calf NNS cord-305859-vt8vwo3y 121 9 showed show VBD cord-305859-vt8vwo3y 121 10 acute acute JJ cord-305859-vt8vwo3y 121 11 fecal fecal JJ cord-305859-vt8vwo3y 121 12 viral viral JJ cord-305859-vt8vwo3y 121 13 RNA RNA NNP cord-305859-vt8vwo3y 121 14 shedding shedding NN cord-305859-vt8vwo3y 121 15 , , , cord-305859-vt8vwo3y 121 16 followed follow VBN cord-305859-vt8vwo3y 121 17 by by IN cord-305859-vt8vwo3y 121 18 progressively progressively RB cord-305859-vt8vwo3y 121 19 decreased decrease VBN cord-305859-vt8vwo3y 121 20 titers titer NNS cord-305859-vt8vwo3y 121 21 thereafter thereafter RB cord-305859-vt8vwo3y 121 22 . . . cord-305859-vt8vwo3y 122 1 There there EX cord-305859-vt8vwo3y 122 2 were be VBD cord-305859-vt8vwo3y 122 3 also also RB cord-305859-vt8vwo3y 122 4 no no DT cord-305859-vt8vwo3y 122 5 PDCoV pdcov RB cord-305859-vt8vwo3y 122 6 RNApositive rnapositive JJ cord-305859-vt8vwo3y 122 7 nasal nasal NN cord-305859-vt8vwo3y 122 8 or or CC cord-305859-vt8vwo3y 122 9 serum serum NN cord-305859-vt8vwo3y 122 10 samples sample NNS cord-305859-vt8vwo3y 122 11 from from IN cord-305859-vt8vwo3y 122 12 PDCoV pdcov RB cord-305859-vt8vwo3y 122 13 - - HYPH cord-305859-vt8vwo3y 122 14 inoculated inoculate VBN cord-305859-vt8vwo3y 122 15 calf calf NN cord-305859-vt8vwo3y 122 16 # # $ cord-305859-vt8vwo3y 122 17 1 1 CD cord-305859-vt8vwo3y 122 18 , , , cord-305859-vt8vwo3y 122 19 indicating indicate VBG cord-305859-vt8vwo3y 122 20 that that IN cord-305859-vt8vwo3y 122 21 PDCoV pdcov CD cord-305859-vt8vwo3y 122 22 infection infection NN cord-305859-vt8vwo3y 122 23 may may MD cord-305859-vt8vwo3y 122 24 be be VB cord-305859-vt8vwo3y 122 25 limited limit VBN cord-305859-vt8vwo3y 122 26 to to IN cord-305859-vt8vwo3y 122 27 the the DT cord-305859-vt8vwo3y 122 28 intestine intestine NN cord-305859-vt8vwo3y 122 29 , , , cord-305859-vt8vwo3y 122 30 similar similar JJ cord-305859-vt8vwo3y 122 31 to to IN cord-305859-vt8vwo3y 122 32 PDCoV pdcov JJ cord-305859-vt8vwo3y 122 33 infections infection NNS cord-305859-vt8vwo3y 122 34 in in IN cord-305859-vt8vwo3y 122 35 pigs pig NNS cord-305859-vt8vwo3y 122 36 [ [ -LRB- cord-305859-vt8vwo3y 122 37 10 10 CD cord-305859-vt8vwo3y 122 38 ] ] -RRB- cord-305859-vt8vwo3y 122 39 , , , cord-305859-vt8vwo3y 122 40 although although IN cord-305859-vt8vwo3y 122 41 PDCoV pdcov RB cord-305859-vt8vwo3y 122 42 - - HYPH cord-305859-vt8vwo3y 122 43 infected infect VBN cord-305859-vt8vwo3y 122 44 pigs pig NNS cord-305859-vt8vwo3y 122 45 also also RB cord-305859-vt8vwo3y 122 46 showed show VBD cord-305859-vt8vwo3y 122 47 viremia viremia NN cord-305859-vt8vwo3y 122 48 ( ( -LRB- cord-305859-vt8vwo3y 122 49 viral viral JJ cord-305859-vt8vwo3y 122 50 RNA RNA NNP cord-305859-vt8vwo3y 122 51 in in IN cord-305859-vt8vwo3y 122 52 serum serum NN cord-305859-vt8vwo3y 122 53 ) ) -RRB- cord-305859-vt8vwo3y 123 1 [ [ -LRB- cord-305859-vt8vwo3y 123 2 10 10 CD cord-305859-vt8vwo3y 123 3 ] ] -RRB- cord-305859-vt8vwo3y 123 4 . . . cord-305859-vt8vwo3y 124 1 Our -PRON- PRP$ cord-305859-vt8vwo3y 124 2 study study NN cord-305859-vt8vwo3y 124 3 did do VBD cord-305859-vt8vwo3y 124 4 not not RB cord-305859-vt8vwo3y 124 5 identify identify VB cord-305859-vt8vwo3y 124 6 which which WDT cord-305859-vt8vwo3y 124 7 type type NN cord-305859-vt8vwo3y 124 8 of of IN cord-305859-vt8vwo3y 124 9 cells cell NNS cord-305859-vt8vwo3y 124 10 in in IN cord-305859-vt8vwo3y 124 11 the the DT cord-305859-vt8vwo3y 124 12 intestines intestine NNS cord-305859-vt8vwo3y 124 13 of of IN cord-305859-vt8vwo3y 124 14 inoculated inoculate VBN cord-305859-vt8vwo3y 124 15 calves calf NNS cord-305859-vt8vwo3y 124 16 could could MD cord-305859-vt8vwo3y 124 17 be be VB cord-305859-vt8vwo3y 124 18 the the DT cord-305859-vt8vwo3y 124 19 target target NN cord-305859-vt8vwo3y 124 20 for for IN cord-305859-vt8vwo3y 124 21 PDCoV pdcov NN cord-305859-vt8vwo3y 124 22 replication replication NN cord-305859-vt8vwo3y 124 23 , , , cord-305859-vt8vwo3y 124 24 resulting result VBG cord-305859-vt8vwo3y 124 25 in in IN cord-305859-vt8vwo3y 124 26 fecal fecal JJ cord-305859-vt8vwo3y 124 27 shedding shedding NN cord-305859-vt8vwo3y 124 28 . . . cord-305859-vt8vwo3y 125 1 Our -PRON- PRP$ cord-305859-vt8vwo3y 125 2 IF if IN cord-305859-vt8vwo3y 125 3 staining stain VBG cord-305859-vt8vwo3y 125 4 experiments experiment NNS cord-305859-vt8vwo3y 125 5 identified identify VBD cord-305859-vt8vwo3y 125 6 PDCoV pdcov NN cord-305859-vt8vwo3y 125 7 antigen antigen NN cord-305859-vt8vwo3y 125 8 - - HYPH cord-305859-vt8vwo3y 125 9 positive positive JJ cord-305859-vt8vwo3y 125 10 cells cell NNS cord-305859-vt8vwo3y 125 11 in in IN cord-305859-vt8vwo3y 125 12 intestinal intestinal JJ cord-305859-vt8vwo3y 125 13 tissues tissue NNS cord-305859-vt8vwo3y 125 14 from from IN cord-305859-vt8vwo3y 125 15 PDCoV pdcov RB cord-305859-vt8vwo3y 125 16 - - HYPH cord-305859-vt8vwo3y 125 17 infected infect VBN cord-305859-vt8vwo3y 125 18 Gn Gn NNP cord-305859-vt8vwo3y 125 19 pigs pig NNS cord-305859-vt8vwo3y 125 20 used use VBN cord-305859-vt8vwo3y 125 21 as as IN cord-305859-vt8vwo3y 125 22 positive positive JJ cord-305859-vt8vwo3y 125 23 controls control NNS cord-305859-vt8vwo3y 125 24 . . . cord-305859-vt8vwo3y 126 1 Similar similar JJ cord-305859-vt8vwo3y 126 2 to to IN cord-305859-vt8vwo3y 126 3 the the DT cord-305859-vt8vwo3y 126 4 GIII.2 giii.2 NN cord-305859-vt8vwo3y 126 5 bovine bovine JJ cord-305859-vt8vwo3y 126 6 norovirus norovirus NN cord-305859-vt8vwo3y 126 7 ( ( -LRB- cord-305859-vt8vwo3y 126 8 CV186-OH cv186-oh CD cord-305859-vt8vwo3y 126 9 strain strain NN cord-305859-vt8vwo3y 126 10 ) ) -RRB- cord-305859-vt8vwo3y 126 11 that that WDT cord-305859-vt8vwo3y 126 12 was be VBD cord-305859-vt8vwo3y 126 13 shown show VBN cord-305859-vt8vwo3y 126 14 to to TO cord-305859-vt8vwo3y 126 15 cause cause VB cord-305859-vt8vwo3y 126 16 fecal fecal JJ cord-305859-vt8vwo3y 126 17 virus virus NN cord-305859-vt8vwo3y 126 18 RNA rna NN cord-305859-vt8vwo3y 126 19 shedding shed VBG cord-305859-vt8vwo3y 126 20 in in IN cord-305859-vt8vwo3y 126 21 infected infected JJ cord-305859-vt8vwo3y 126 22 Gn Gn NNP cord-305859-vt8vwo3y 126 23 calves calf NNS cord-305859-vt8vwo3y 126 24 , , , cord-305859-vt8vwo3y 126 25 but but CC cord-305859-vt8vwo3y 126 26 in in IN cord-305859-vt8vwo3y 126 27 the the DT cord-305859-vt8vwo3y 126 28 absence absence NN cord-305859-vt8vwo3y 126 29 of of IN cord-305859-vt8vwo3y 126 30 histological histological JJ cord-305859-vt8vwo3y 126 31 lesions lesion NNS cord-305859-vt8vwo3y 126 32 or or CC cord-305859-vt8vwo3y 126 33 viral viral JJ cord-305859-vt8vwo3y 126 34 antigen antigen NN cord-305859-vt8vwo3y 126 35 / / SYM cord-305859-vt8vwo3y 126 36 RNA RNA NNP cord-305859-vt8vwo3y 126 37 in in IN cord-305859-vt8vwo3y 126 38 the the DT cord-305859-vt8vwo3y 126 39 intestine intestine NN cord-305859-vt8vwo3y 126 40 [ [ -LRB- cord-305859-vt8vwo3y 126 41 5 5 CD cord-305859-vt8vwo3y 126 42 ] ] -RRB- cord-305859-vt8vwo3y 126 43 , , , cord-305859-vt8vwo3y 126 44 PDCoV pdcov ADD cord-305859-vt8vwo3y 126 45 did do VBD cord-305859-vt8vwo3y 126 46 not not RB cord-305859-vt8vwo3y 126 47 induce induce VB cord-305859-vt8vwo3y 126 48 major major JJ cord-305859-vt8vwo3y 126 49 histological histological JJ cord-305859-vt8vwo3y 126 50 changes change NNS cord-305859-vt8vwo3y 126 51 in in IN cord-305859-vt8vwo3y 126 52 the the DT cord-305859-vt8vwo3y 126 53 intestine intestine NN cord-305859-vt8vwo3y 126 54 of of IN cord-305859-vt8vwo3y 126 55 Gn Gn NNP cord-305859-vt8vwo3y 126 56 calves calf NNS cord-305859-vt8vwo3y 126 57 , , , cord-305859-vt8vwo3y 126 58 such such JJ cord-305859-vt8vwo3y 126 59 as as IN cord-305859-vt8vwo3y 126 60 necrosis necrosis NN cord-305859-vt8vwo3y 126 61 of of IN cord-305859-vt8vwo3y 126 62 intestinal intestinal JJ cord-305859-vt8vwo3y 126 63 epithelium epithelium NN cord-305859-vt8vwo3y 126 64 or or CC cord-305859-vt8vwo3y 126 65 villous villous NN cord-305859-vt8vwo3y 126 66 atrophy atrophy NN cord-305859-vt8vwo3y 126 67 . . . cord-305859-vt8vwo3y 127 1 This this DT cord-305859-vt8vwo3y 127 2 result result NN cord-305859-vt8vwo3y 127 3 is be VBZ cord-305859-vt8vwo3y 127 4 also also RB cord-305859-vt8vwo3y 127 5 in in IN cord-305859-vt8vwo3y 127 6 line line NN cord-305859-vt8vwo3y 127 7 with with IN cord-305859-vt8vwo3y 127 8 data datum NNS cord-305859-vt8vwo3y 127 9 showing show VBG cord-305859-vt8vwo3y 127 10 no no DT cord-305859-vt8vwo3y 127 11 PDCoV pdcov RB cord-305859-vt8vwo3y 127 12 - - HYPH cord-305859-vt8vwo3y 127 13 positive positive JJ cord-305859-vt8vwo3y 127 14 cells cell NNS cord-305859-vt8vwo3y 127 15 in in IN cord-305859-vt8vwo3y 127 16 the the DT cord-305859-vt8vwo3y 127 17 intestinal intestinal JJ cord-305859-vt8vwo3y 127 18 epithelium epithelium NN cord-305859-vt8vwo3y 127 19 . . . cord-305859-vt8vwo3y 128 1 Based base VBN cord-305859-vt8vwo3y 128 2 on on IN cord-305859-vt8vwo3y 128 3 these these DT cord-305859-vt8vwo3y 128 4 observations observation NNS cord-305859-vt8vwo3y 128 5 , , , cord-305859-vt8vwo3y 128 6 PDCoV pdcov ADD cord-305859-vt8vwo3y 128 7 may may MD cord-305859-vt8vwo3y 128 8 have have VB cord-305859-vt8vwo3y 128 9 infected infect VBN cord-305859-vt8vwo3y 128 10 the the DT cord-305859-vt8vwo3y 128 11 intestine intestine NN cord-305859-vt8vwo3y 128 12 of of IN cord-305859-vt8vwo3y 128 13 calves calf NNS cord-305859-vt8vwo3y 128 14 as as IN cord-305859-vt8vwo3y 128 15 an an DT cord-305859-vt8vwo3y 128 16 attenuated attenuated JJ cord-305859-vt8vwo3y 128 17 virus virus NN cord-305859-vt8vwo3y 128 18 that that WDT cord-305859-vt8vwo3y 128 19 does do VBZ cord-305859-vt8vwo3y 128 20 not not RB cord-305859-vt8vwo3y 128 21 cause cause VB cord-305859-vt8vwo3y 128 22 clinical clinical JJ cord-305859-vt8vwo3y 128 23 disease disease NN cord-305859-vt8vwo3y 128 24 and and CC cord-305859-vt8vwo3y 128 25 histological histological JJ cord-305859-vt8vwo3y 128 26 lesions lesion NNS cord-305859-vt8vwo3y 128 27 , , , cord-305859-vt8vwo3y 128 28 with with IN cord-305859-vt8vwo3y 128 29 low low JJ cord-305859-vt8vwo3y 128 30 levels level NNS cord-305859-vt8vwo3y 128 31 of of IN cord-305859-vt8vwo3y 128 32 viral viral JJ cord-305859-vt8vwo3y 128 33 antigen antigen NN cord-305859-vt8vwo3y 128 34 detected detect VBN cord-305859-vt8vwo3y 128 35 in in IN cord-305859-vt8vwo3y 128 36 enterocytes enterocyte NNS cord-305859-vt8vwo3y 128 37 in in IN cord-305859-vt8vwo3y 128 38 inoculated inoculate VBN cord-305859-vt8vwo3y 128 39 animals animal NNS cord-305859-vt8vwo3y 128 40 . . . cord-305859-vt8vwo3y 129 1 Nevertheless nevertheless RB cord-305859-vt8vwo3y 129 2 , , , cord-305859-vt8vwo3y 129 3 our -PRON- PRP$ cord-305859-vt8vwo3y 129 4 study study NN cord-305859-vt8vwo3y 129 5 did do VBD cord-305859-vt8vwo3y 129 6 not not RB cord-305859-vt8vwo3y 129 7 clearly clearly RB cord-305859-vt8vwo3y 129 8 rule rule VB cord-305859-vt8vwo3y 129 9 out out RP cord-305859-vt8vwo3y 129 10 an an DT cord-305859-vt8vwo3y 129 11 abortive abortive JJ cord-305859-vt8vwo3y 129 12 infection infection NN cord-305859-vt8vwo3y 129 13 with with IN cord-305859-vt8vwo3y 129 14 limited limited JJ cord-305859-vt8vwo3y 129 15 PDCoV pdcov CD cord-305859-vt8vwo3y 129 16 replication replication NN cord-305859-vt8vwo3y 129 17 in in IN cord-305859-vt8vwo3y 129 18 calves calf NNS cord-305859-vt8vwo3y 129 19 . . . cord-305859-vt8vwo3y 130 1 In in IN cord-305859-vt8vwo3y 130 2 addition addition NN cord-305859-vt8vwo3y 130 3 , , , cord-305859-vt8vwo3y 130 4 interestingly interestingly RB cord-305859-vt8vwo3y 130 5 , , , cord-305859-vt8vwo3y 130 6 no no DT cord-305859-vt8vwo3y 130 7 PEDV pedv NN cord-305859-vt8vwo3y 130 8 - - HYPH cord-305859-vt8vwo3y 130 9 specific specific JJ cord-305859-vt8vwo3y 130 10 IgG igg NN cord-305859-vt8vwo3y 130 11 antibodies antibody NNS cord-305859-vt8vwo3y 130 12 were be VBD cord-305859-vt8vwo3y 130 13 detected detect VBN cord-305859-vt8vwo3y 130 14 by by IN cord-305859-vt8vwo3y 130 15 IFA IFA NNP cord-305859-vt8vwo3y 130 16 in in IN cord-305859-vt8vwo3y 130 17 the the DT cord-305859-vt8vwo3y 130 18 serum serum NN cord-305859-vt8vwo3y 130 19 of of IN cord-305859-vt8vwo3y 130 20 PEDV PEDV NNP cord-305859-vt8vwo3y 130 21 - - HYPH cord-305859-vt8vwo3y 130 22 inoculated inoculate VBN cord-305859-vt8vwo3y 130 23 calf calf NN cord-305859-vt8vwo3y 130 24 # # $ cord-305859-vt8vwo3y 130 25 5 5 CD cord-305859-vt8vwo3y 130 26 at at IN cord-305859-vt8vwo3y 130 27 PID PID NNP cord-305859-vt8vwo3y 130 28 16 16 CD cord-305859-vt8vwo3y 130 29 . . . cord-305859-vt8vwo3y 131 1 However however RB cord-305859-vt8vwo3y 131 2 , , , cord-305859-vt8vwo3y 131 3 a a DT cord-305859-vt8vwo3y 131 4 virus virus NN cord-305859-vt8vwo3y 131 5 neutralization neutralization NN cord-305859-vt8vwo3y 131 6 ( ( -LRB- cord-305859-vt8vwo3y 131 7 VN VN NNP cord-305859-vt8vwo3y 131 8 ) ) -RRB- cord-305859-vt8vwo3y 131 9 assay assay NN cord-305859-vt8vwo3y 131 10 using use VBG cord-305859-vt8vwo3y 131 11 a a DT cord-305859-vt8vwo3y 131 12 PEDV PEDV NNP cord-305859-vt8vwo3y 131 13 strain strain NN cord-305859-vt8vwo3y 131 14 Iowa106 iowa106 XX cord-305859-vt8vwo3y 131 15 [ [ -LRB- cord-305859-vt8vwo3y 131 16 3 3 CD cord-305859-vt8vwo3y 131 17 , , , cord-305859-vt8vwo3y 131 18 12 12 CD cord-305859-vt8vwo3y 131 19 ] ] -RRB- cord-305859-vt8vwo3y 131 20 , , , cord-305859-vt8vwo3y 131 21 showed show VBD cord-305859-vt8vwo3y 131 22 low low JJ cord-305859-vt8vwo3y 131 23 PEDV PEDV NNP cord-305859-vt8vwo3y 131 24 neutralizing neutralize VBG cord-305859-vt8vwo3y 131 25 activity activity NN cord-305859-vt8vwo3y 131 26 in in IN cord-305859-vt8vwo3y 131 27 the the DT cord-305859-vt8vwo3y 131 28 sera sera NNP cord-305859-vt8vwo3y 131 29 of of IN cord-305859-vt8vwo3y 131 30 calf calf NN cord-305859-vt8vwo3y 131 31 # # $ cord-305859-vt8vwo3y 131 32 5 5 CD cord-305859-vt8vwo3y 131 33 at at IN cord-305859-vt8vwo3y 131 34 PID PID NNP cord-305859-vt8vwo3y 131 35 16 16 CD cord-305859-vt8vwo3y 131 36 and and CC cord-305859-vt8vwo3y 131 37 prebled preble VBD cord-305859-vt8vwo3y 131 38 prior prior RB cord-305859-vt8vwo3y 131 39 to to IN cord-305859-vt8vwo3y 131 40 PEDV PEDV NNP cord-305859-vt8vwo3y 131 41 inoculation inoculation NN cord-305859-vt8vwo3y 131 42 , , , cord-305859-vt8vwo3y 131 43 with with IN cord-305859-vt8vwo3y 131 44 VN VN NNP cord-305859-vt8vwo3y 131 45 titers titer NNS cord-305859-vt8vwo3y 131 46 of of IN cord-305859-vt8vwo3y 131 47 4 4 CD cord-305859-vt8vwo3y 131 48 2.8 2.8 CD cord-305859-vt8vwo3y 131 49 ( ( -LRB- cord-305859-vt8vwo3y 131 50 PID PID NNP cord-305859-vt8vwo3y 131 51 16 16 CD cord-305859-vt8vwo3y 131 52 ) ) -RRB- cord-305859-vt8vwo3y 131 53 and and CC cord-305859-vt8vwo3y 131 54 4 4 CD cord-305859-vt8vwo3y 131 55 2.5 2.5 CD cord-305859-vt8vwo3y 131 56 ( ( -LRB- cord-305859-vt8vwo3y 131 57 prebled prebled JJ cord-305859-vt8vwo3y 131 58 ) ) -RRB- cord-305859-vt8vwo3y 131 59 . . . cord-305859-vt8vwo3y 132 1 Additional additional JJ cord-305859-vt8vwo3y 132 2 studies study NNS cord-305859-vt8vwo3y 132 3 using use VBG cord-305859-vt8vwo3y 132 4 larger large JJR cord-305859-vt8vwo3y 132 5 numbers number NNS cord-305859-vt8vwo3y 132 6 of of IN cord-305859-vt8vwo3y 132 7 serum serum NN cord-305859-vt8vwo3y 132 8 samples sample NNS cord-305859-vt8vwo3y 132 9 are be VBP cord-305859-vt8vwo3y 132 10 needed need VBN cord-305859-vt8vwo3y 132 11 to to TO cord-305859-vt8vwo3y 132 12 confirm confirm VB cord-305859-vt8vwo3y 132 13 whether whether IN cord-305859-vt8vwo3y 132 14 bovine bovine JJ cord-305859-vt8vwo3y 132 15 sera sera NNP cord-305859-vt8vwo3y 132 16 have have VBP cord-305859-vt8vwo3y 132 17 PEDV PEDV NNP cord-305859-vt8vwo3y 132 18 antibodies antibody NNS cord-305859-vt8vwo3y 132 19 or or CC cord-305859-vt8vwo3y 132 20 neutralizing neutralize VBG cord-305859-vt8vwo3y 132 21 substances substance NNS cord-305859-vt8vwo3y 132 22 . . . cord-305859-vt8vwo3y 133 1 Collectively collectively RB cord-305859-vt8vwo3y 133 2 , , , cord-305859-vt8vwo3y 133 3 our -PRON- PRP$ cord-305859-vt8vwo3y 133 4 data datum NNS cord-305859-vt8vwo3y 133 5 indicate indicate VBP cord-305859-vt8vwo3y 133 6 that that IN cord-305859-vt8vwo3y 133 7 calves calf NNS cord-305859-vt8vwo3y 133 8 are be VBP cord-305859-vt8vwo3y 133 9 susceptible susceptible JJ cord-305859-vt8vwo3y 133 10 to to IN cord-305859-vt8vwo3y 133 11 infection infection NN cord-305859-vt8vwo3y 133 12 with with IN cord-305859-vt8vwo3y 133 13 the the DT cord-305859-vt8vwo3y 133 14 newly newly RB cord-305859-vt8vwo3y 133 15 emerged emerge VBN cord-305859-vt8vwo3y 133 16 PDCoV pdcov DT cord-305859-vt8vwo3y 133 17 , , , cord-305859-vt8vwo3y 133 18 but but CC cord-305859-vt8vwo3y 133 19 not not RB cord-305859-vt8vwo3y 133 20 with with IN cord-305859-vt8vwo3y 133 21 the the DT cord-305859-vt8vwo3y 133 22 swine swine NNP cord-305859-vt8vwo3y 133 23 enteric enteric JJ cord-305859-vt8vwo3y 133 24 CoV cov NN cord-305859-vt8vwo3y 133 25 , , , cord-305859-vt8vwo3y 133 26 PEDV PEDV NNP cord-305859-vt8vwo3y 133 27 . . . cord-305859-vt8vwo3y 134 1 However however RB cord-305859-vt8vwo3y 134 2 , , , cord-305859-vt8vwo3y 134 3 the the DT cord-305859-vt8vwo3y 134 4 infectivity infectivity NN cord-305859-vt8vwo3y 134 5 of of IN cord-305859-vt8vwo3y 134 6 PDCoV pdcov NN cord-305859-vt8vwo3y 134 7 in in IN cord-305859-vt8vwo3y 134 8 calves calf NNS cord-305859-vt8vwo3y 134 9 was be VBD cord-305859-vt8vwo3y 134 10 limited limit VBN cord-305859-vt8vwo3y 134 11 , , , cord-305859-vt8vwo3y 134 12 as as IN cord-305859-vt8vwo3y 134 13 manifested manifest VBN cord-305859-vt8vwo3y 134 14 by by IN cord-305859-vt8vwo3y 134 15 no no DT cord-305859-vt8vwo3y 134 16 clinical clinical JJ cord-305859-vt8vwo3y 134 17 disease disease NN cord-305859-vt8vwo3y 134 18 and and CC cord-305859-vt8vwo3y 134 19 histological histological JJ cord-305859-vt8vwo3y 134 20 lesions lesion NNS cord-305859-vt8vwo3y 134 21 , , , cord-305859-vt8vwo3y 134 22 possibly possibly RB cord-305859-vt8vwo3y 134 23 due due IN cord-305859-vt8vwo3y 134 24 to to IN cord-305859-vt8vwo3y 134 25 its -PRON- PRP$ cord-305859-vt8vwo3y 134 26 incomplete incomplete JJ cord-305859-vt8vwo3y 134 27 adaptation adaptation NN cord-305859-vt8vwo3y 134 28 to to IN cord-305859-vt8vwo3y 134 29 the the DT cord-305859-vt8vwo3y 134 30 bovine bovine JJ cord-305859-vt8vwo3y 134 31 intestine intestine NN cord-305859-vt8vwo3y 134 32 . . . cord-305859-vt8vwo3y 135 1 Other other JJ cord-305859-vt8vwo3y 135 2 animal animal NN cord-305859-vt8vwo3y 135 3 species specie NNS cord-305859-vt8vwo3y 135 4 with with IN cord-305859-vt8vwo3y 135 5 frequent frequent JJ cord-305859-vt8vwo3y 135 6 contacts contact NNS cord-305859-vt8vwo3y 135 7 with with IN cord-305859-vt8vwo3y 135 8 pigs pig NNS cord-305859-vt8vwo3y 135 9 , , , cord-305859-vt8vwo3y 135 10 such such JJ cord-305859-vt8vwo3y 135 11 as as IN cord-305859-vt8vwo3y 135 12 poultry poultry NN cord-305859-vt8vwo3y 135 13 , , , cord-305859-vt8vwo3y 135 14 also also RB cord-305859-vt8vwo3y 135 15 need need VBP cord-305859-vt8vwo3y 135 16 to to TO cord-305859-vt8vwo3y 135 17 be be VB cord-305859-vt8vwo3y 135 18 monitored monitor VBN cord-305859-vt8vwo3y 135 19 for for IN cord-305859-vt8vwo3y 135 20 potential potential JJ cord-305859-vt8vwo3y 135 21 infectivity infectivity NN cord-305859-vt8vwo3y 135 22 by by IN cord-305859-vt8vwo3y 135 23 PDCoV. PDCoV. NNP cord-305859-vt8vwo3y 135 24 Detection Detection NNP cord-305859-vt8vwo3y 135 25 of of IN cord-305859-vt8vwo3y 135 26 a a DT cord-305859-vt8vwo3y 135 27 novel novel NN cord-305859-vt8vwo3y 135 28 and and CC cord-305859-vt8vwo3y 135 29 highly highly RB cord-305859-vt8vwo3y 135 30 divergent divergent JJ cord-305859-vt8vwo3y 135 31 coronavirus coronavirus NN cord-305859-vt8vwo3y 135 32 from from IN cord-305859-vt8vwo3y 135 33 asian asian JJ cord-305859-vt8vwo3y 135 34 leopard leopard NN cord-305859-vt8vwo3y 135 35 cats cat NNS cord-305859-vt8vwo3y 135 36 and and CC cord-305859-vt8vwo3y 135 37 Chinese chinese JJ cord-305859-vt8vwo3y 135 38 ferret ferret JJ cord-305859-vt8vwo3y 135 39 badgers badger NNS cord-305859-vt8vwo3y 135 40 in in IN cord-305859-vt8vwo3y 135 41 Southern Southern NNP cord-305859-vt8vwo3y 135 42 China China NNP cord-305859-vt8vwo3y 135 43 Isolation isolation NN cord-305859-vt8vwo3y 135 44 and and CC cord-305859-vt8vwo3y 135 45 characterization characterization NN cord-305859-vt8vwo3y 135 46 of of IN cord-305859-vt8vwo3y 135 47 porcine porcine JJ cord-305859-vt8vwo3y 135 48 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 135 49 from from IN cord-305859-vt8vwo3y 135 50 pigs pig NNS cord-305859-vt8vwo3y 135 51 with with IN cord-305859-vt8vwo3y 135 52 diarrhea diarrhea NN cord-305859-vt8vwo3y 135 53 in in IN cord-305859-vt8vwo3y 135 54 the the DT cord-305859-vt8vwo3y 135 55 United United NNP cord-305859-vt8vwo3y 135 56 States States NNP cord-305859-vt8vwo3y 135 57 Experimental experimental JJ cord-305859-vt8vwo3y 135 58 infection infection NN cord-305859-vt8vwo3y 135 59 of of IN cord-305859-vt8vwo3y 135 60 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 135 61 pigs pig NNS cord-305859-vt8vwo3y 135 62 with with IN cord-305859-vt8vwo3y 135 63 the the DT cord-305859-vt8vwo3y 135 64 cell cell NN cord-305859-vt8vwo3y 135 65 - - HYPH cord-305859-vt8vwo3y 135 66 culture culture NN cord-305859-vt8vwo3y 135 67 - - HYPH cord-305859-vt8vwo3y 135 68 adapted adapt VBN cord-305859-vt8vwo3y 135 69 porcine porcine JJ cord-305859-vt8vwo3y 135 70 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 136 1 strain strain VB cord-305859-vt8vwo3y 136 2 OH OH NNP cord-305859-vt8vwo3y 136 3 - - HYPH cord-305859-vt8vwo3y 136 4 FD22 FD22 NNP cord-305859-vt8vwo3y 136 5 Altered altered JJ cord-305859-vt8vwo3y 136 6 pathogenesis pathogenesis NN cord-305859-vt8vwo3y 136 7 of of IN cord-305859-vt8vwo3y 136 8 porcine porcine JJ cord-305859-vt8vwo3y 136 9 respiratory respiratory JJ cord-305859-vt8vwo3y 136 10 coronavirus coronavirus NN cord-305859-vt8vwo3y 136 11 in in IN cord-305859-vt8vwo3y 136 12 pigs pig NNS cord-305859-vt8vwo3y 136 13 due due JJ cord-305859-vt8vwo3y 136 14 to to IN cord-305859-vt8vwo3y 136 15 immunosuppressive immunosuppressive JJ cord-305859-vt8vwo3y 136 16 effects effect NNS cord-305859-vt8vwo3y 136 17 of of IN cord-305859-vt8vwo3y 136 18 dexamethasone dexamethasone NN cord-305859-vt8vwo3y 136 19 : : : cord-305859-vt8vwo3y 136 20 implications implication NNS cord-305859-vt8vwo3y 136 21 for for IN cord-305859-vt8vwo3y 136 22 corticosteroid corticosteroid NN cord-305859-vt8vwo3y 136 23 use use NN cord-305859-vt8vwo3y 136 24 in in IN cord-305859-vt8vwo3y 136 25 treatment treatment NN cord-305859-vt8vwo3y 136 26 of of IN cord-305859-vt8vwo3y 136 27 severe severe JJ cord-305859-vt8vwo3y 136 28 acute acute JJ cord-305859-vt8vwo3y 136 29 respiratory respiratory JJ cord-305859-vt8vwo3y 136 30 syndrome syndrome NN cord-305859-vt8vwo3y 136 31 coronavirus coronavirus NN cord-305859-vt8vwo3y 136 32 Pathogenesis Pathogenesis NNP cord-305859-vt8vwo3y 136 33 of of IN cord-305859-vt8vwo3y 136 34 GIII.2 GIII.2 NNP cord-305859-vt8vwo3y 136 35 bovine bovine JJ cord-305859-vt8vwo3y 136 36 norovirus norovirus NN cord-305859-vt8vwo3y 136 37 , , , cord-305859-vt8vwo3y 136 38 CV186-OH/00 CV186-OH/00 NNP cord-305859-vt8vwo3y 136 39 / / SYM cord-305859-vt8vwo3y 136 40 US US NNP cord-305859-vt8vwo3y 136 41 strain strain NN cord-305859-vt8vwo3y 136 42 in in IN cord-305859-vt8vwo3y 136 43 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 136 44 calves calf NNS cord-305859-vt8vwo3y 136 45 Pathology Pathology NNP cord-305859-vt8vwo3y 136 46 of of IN cord-305859-vt8vwo3y 136 47 US US NNP cord-305859-vt8vwo3y 136 48 porcine porcine JJ cord-305859-vt8vwo3y 136 49 epidemic epidemic NN cord-305859-vt8vwo3y 136 50 diarrhea diarrhea NN cord-305859-vt8vwo3y 136 51 virus virus NN cord-305859-vt8vwo3y 137 1 strain strain NN cord-305859-vt8vwo3y 137 2 PC21A pc21a JJ cord-305859-vt8vwo3y 137 3 in in IN cord-305859-vt8vwo3y 137 4 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 137 5 pigs pig NNS cord-305859-vt8vwo3y 138 1 Comparative comparative JJ cord-305859-vt8vwo3y 138 2 pathogenesis pathogenesis NN cord-305859-vt8vwo3y 138 3 of of IN cord-305859-vt8vwo3y 138 4 US US NNP cord-305859-vt8vwo3y 138 5 porcine porcine JJ cord-305859-vt8vwo3y 138 6 epidemic epidemic NN cord-305859-vt8vwo3y 138 7 diarrhea diarrhea NN cord-305859-vt8vwo3y 138 8 virus virus NN cord-305859-vt8vwo3y 138 9 ( ( -LRB- cord-305859-vt8vwo3y 138 10 PEDV PEDV NNP cord-305859-vt8vwo3y 138 11 ) ) -RRB- cord-305859-vt8vwo3y 138 12 strain strain VBP cord-305859-vt8vwo3y 138 13 PC21A PC21A VBN cord-305859-vt8vwo3y 138 14 in in IN cord-305859-vt8vwo3y 138 15 conventional conventional JJ cord-305859-vt8vwo3y 138 16 9-day 9-day JJ cord-305859-vt8vwo3y 138 17 - - HYPH cord-305859-vt8vwo3y 138 18 old old JJ cord-305859-vt8vwo3y 138 19 nursing nursing NN cord-305859-vt8vwo3y 138 20 piglets piglet NNS cord-305859-vt8vwo3y 138 21 vs. vs. IN cord-305859-vt8vwo3y 138 22 26-day 26-day CD cord-305859-vt8vwo3y 138 23 - - HYPH cord-305859-vt8vwo3y 138 24 old old JJ cord-305859-vt8vwo3y 139 1 weaned wean VBN cord-305859-vt8vwo3y 139 2 pigs pig NNS cord-305859-vt8vwo3y 139 3 Pathogenicity Pathogenicity NNP cord-305859-vt8vwo3y 139 4 of of IN cord-305859-vt8vwo3y 139 5 2 2 CD cord-305859-vt8vwo3y 139 6 porcine porcine JJ cord-305859-vt8vwo3y 139 7 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 139 8 strains strain NNS cord-305859-vt8vwo3y 139 9 in in IN cord-305859-vt8vwo3y 139 10 gnotobiotic gnotobiotic JJ cord-305859-vt8vwo3y 139 11 pigs pig NNS cord-305859-vt8vwo3y 139 12 Porcine porcine JJ cord-305859-vt8vwo3y 139 13 epidemic epidemic NN cord-305859-vt8vwo3y 139 14 diarrhea diarrhea NN cord-305859-vt8vwo3y 139 15 virus virus NN cord-305859-vt8vwo3y 139 16 infection infection NN cord-305859-vt8vwo3y 139 17 : : : cord-305859-vt8vwo3y 140 1 Etiology etiology NN cord-305859-vt8vwo3y 140 2 , , , cord-305859-vt8vwo3y 140 3 epidemiology epidemiology NN cord-305859-vt8vwo3y 140 4 , , , cord-305859-vt8vwo3y 140 5 pathogenesis pathogenesis NN cord-305859-vt8vwo3y 140 6 and and CC cord-305859-vt8vwo3y 140 7 immunoprophylaxis immunoprophylaxis JJ cord-305859-vt8vwo3y 140 8 Porcine porcine JJ cord-305859-vt8vwo3y 140 9 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 140 10 infection infection NN cord-305859-vt8vwo3y 140 11 : : : cord-305859-vt8vwo3y 140 12 Etiology etiology NN cord-305859-vt8vwo3y 140 13 , , , cord-305859-vt8vwo3y 140 14 cell cell NN cord-305859-vt8vwo3y 140 15 culture culture NN cord-305859-vt8vwo3y 140 16 for for IN cord-305859-vt8vwo3y 140 17 virus virus NN cord-305859-vt8vwo3y 140 18 isolation isolation NN cord-305859-vt8vwo3y 140 19 and and CC cord-305859-vt8vwo3y 140 20 propagation propagation NN cord-305859-vt8vwo3y 140 21 , , , cord-305859-vt8vwo3y 141 1 molecular molecular JJ cord-305859-vt8vwo3y 141 2 epidemiology epidemiology NN cord-305859-vt8vwo3y 141 3 and and CC cord-305859-vt8vwo3y 141 4 pathogenesis pathogenesis NN cord-305859-vt8vwo3y 141 5 Characterization characterization NN cord-305859-vt8vwo3y 141 6 of of IN cord-305859-vt8vwo3y 141 7 Porcine Porcine NNP cord-305859-vt8vwo3y 141 8 Epidemic Epidemic NNP cord-305859-vt8vwo3y 141 9 Diarrhea Diarrhea NNP cord-305859-vt8vwo3y 141 10 Virus virus NN cord-305859-vt8vwo3y 141 11 Isolate isolate VBP cord-305859-vt8vwo3y 141 12 US US NNP cord-305859-vt8vwo3y 141 13 / / SYM cord-305859-vt8vwo3y 141 14 Iowa/18984/2013 Iowa/18984/2013 NNP cord-305859-vt8vwo3y 141 15 Infection infection NN cord-305859-vt8vwo3y 141 16 in in IN cord-305859-vt8vwo3y 141 17 1-Day 1-day JJ cord-305859-vt8vwo3y 141 18 - - HYPH cord-305859-vt8vwo3y 141 19 Old old JJ cord-305859-vt8vwo3y 141 20 Cesarean Cesarean NNP cord-305859-vt8vwo3y 141 21 - - HYPH cord-305859-vt8vwo3y 141 22 Derived derive VBN cord-305859-vt8vwo3y 141 23 Colostrum colostrum NN cord-305859-vt8vwo3y 141 24 - - HYPH cord-305859-vt8vwo3y 141 25 Deprived deprive VBN cord-305859-vt8vwo3y 141 26 Piglets piglet NNS cord-305859-vt8vwo3y 141 27 Cell cell NN cord-305859-vt8vwo3y 141 28 culture culture NN cord-305859-vt8vwo3y 141 29 isolation isolation NN cord-305859-vt8vwo3y 141 30 and and CC cord-305859-vt8vwo3y 141 31 sequence sequence NN cord-305859-vt8vwo3y 141 32 analysis analysis NN cord-305859-vt8vwo3y 141 33 of of IN cord-305859-vt8vwo3y 141 34 genetically genetically RB cord-305859-vt8vwo3y 141 35 diverse diverse JJ cord-305859-vt8vwo3y 141 36 US US NNP cord-305859-vt8vwo3y 141 37 porcine porcine JJ cord-305859-vt8vwo3y 141 38 epidemic epidemic NN cord-305859-vt8vwo3y 141 39 diarrhea diarrhea NN cord-305859-vt8vwo3y 141 40 virus virus NN cord-305859-vt8vwo3y 141 41 strains strain VBZ cord-305859-vt8vwo3y 141 42 including include VBG cord-305859-vt8vwo3y 141 43 a a DT cord-305859-vt8vwo3y 141 44 novel novel JJ cord-305859-vt8vwo3y 141 45 strain strain NN cord-305859-vt8vwo3y 141 46 with with IN cord-305859-vt8vwo3y 141 47 a a DT cord-305859-vt8vwo3y 141 48 large large JJ cord-305859-vt8vwo3y 141 49 deletion deletion NN cord-305859-vt8vwo3y 141 50 in in IN cord-305859-vt8vwo3y 141 51 the the DT cord-305859-vt8vwo3y 141 52 spike spike NN cord-305859-vt8vwo3y 141 53 gene gene NN cord-305859-vt8vwo3y 141 54 A a DT cord-305859-vt8vwo3y 141 55 mouse mouse NN cord-305859-vt8vwo3y 141 56 - - HYPH cord-305859-vt8vwo3y 141 57 adapted adapt VBN cord-305859-vt8vwo3y 141 58 SARS SARS NNP cord-305859-vt8vwo3y 141 59 - - HYPH cord-305859-vt8vwo3y 141 60 coronavirus coronavirus NN cord-305859-vt8vwo3y 141 61 causes cause VBZ cord-305859-vt8vwo3y 141 62 disease disease NN cord-305859-vt8vwo3y 141 63 and and CC cord-305859-vt8vwo3y 141 64 mortality mortality NN cord-305859-vt8vwo3y 141 65 in in IN cord-305859-vt8vwo3y 141 66 BALB BALB NNP cord-305859-vt8vwo3y 141 67 / / SYM cord-305859-vt8vwo3y 141 68 c c NN cord-305859-vt8vwo3y 141 69 mice mouse NNS cord-305859-vt8vwo3y 141 70 Porcine porcine JJ cord-305859-vt8vwo3y 141 71 aminopeptidase aminopeptidase NN cord-305859-vt8vwo3y 142 1 N N NNP cord-305859-vt8vwo3y 142 2 is be VBZ cord-305859-vt8vwo3y 142 3 not not RB cord-305859-vt8vwo3y 142 4 a a DT cord-305859-vt8vwo3y 142 5 cellular cellular JJ cord-305859-vt8vwo3y 142 6 receptor receptor NN cord-305859-vt8vwo3y 142 7 of of IN cord-305859-vt8vwo3y 142 8 porcine porcine JJ cord-305859-vt8vwo3y 142 9 epidemic epidemic NN cord-305859-vt8vwo3y 142 10 diarrhoea diarrhoea NN cord-305859-vt8vwo3y 142 11 virus virus NN cord-305859-vt8vwo3y 142 12 , , , cord-305859-vt8vwo3y 142 13 but but CC cord-305859-vt8vwo3y 142 14 promotes promote VBZ cord-305859-vt8vwo3y 142 15 its -PRON- PRP$ cord-305859-vt8vwo3y 142 16 infectivity infectivity NN cord-305859-vt8vwo3y 142 17 via via IN cord-305859-vt8vwo3y 142 18 aminopeptidase aminopeptidase NN cord-305859-vt8vwo3y 142 19 activity activity NN cord-305859-vt8vwo3y 142 20 Proteolytic Proteolytic NNP cord-305859-vt8vwo3y 142 21 activation activation NN cord-305859-vt8vwo3y 142 22 of of IN cord-305859-vt8vwo3y 142 23 the the DT cord-305859-vt8vwo3y 142 24 SARS SARS NNP cord-305859-vt8vwo3y 142 25 - - HYPH cord-305859-vt8vwo3y 142 26 coronavirus coronavirus NN cord-305859-vt8vwo3y 142 27 spike spike NN cord-305859-vt8vwo3y 142 28 protein protein NN cord-305859-vt8vwo3y 142 29 : : : cord-305859-vt8vwo3y 142 30 cutting cut VBG cord-305859-vt8vwo3y 142 31 enzymes enzyme NNS cord-305859-vt8vwo3y 142 32 at at IN cord-305859-vt8vwo3y 142 33 the the DT cord-305859-vt8vwo3y 142 34 cutting cutting JJ cord-305859-vt8vwo3y 142 35 edge edge NN cord-305859-vt8vwo3y 142 36 of of IN cord-305859-vt8vwo3y 142 37 antiviral antiviral JJ cord-305859-vt8vwo3y 142 38 research research NN cord-305859-vt8vwo3y 142 39 Epidemiology Epidemiology NNP cord-305859-vt8vwo3y 142 40 , , , cord-305859-vt8vwo3y 142 41 Genetic Genetic NNP cord-305859-vt8vwo3y 142 42 Recombination Recombination NNP cord-305859-vt8vwo3y 142 43 , , , cord-305859-vt8vwo3y 142 44 and and CC cord-305859-vt8vwo3y 142 45 Pathogenesis Pathogenesis NNP cord-305859-vt8vwo3y 142 46 of of IN cord-305859-vt8vwo3y 142 47 Coronaviruses Coronaviruses NNP cord-305859-vt8vwo3y 142 48 Detection Detection NNP cord-305859-vt8vwo3y 142 49 and and CC cord-305859-vt8vwo3y 142 50 genetic genetic JJ cord-305859-vt8vwo3y 142 51 characterization characterization NN cord-305859-vt8vwo3y 142 52 of of IN cord-305859-vt8vwo3y 142 53 deltacoronavirus deltacoronavirus NN cord-305859-vt8vwo3y 142 54 in in IN cord-305859-vt8vwo3y 142 55 pigs pig NNS cord-305859-vt8vwo3y 142 56 Discovery Discovery NNP cord-305859-vt8vwo3y 142 57 of of IN cord-305859-vt8vwo3y 142 58 seven seven CD cord-305859-vt8vwo3y 142 59 novel novel NN cord-305859-vt8vwo3y 142 60 Mammalian mammalian JJ cord-305859-vt8vwo3y 142 61 and and CC cord-305859-vt8vwo3y 142 62 avian avian JJ cord-305859-vt8vwo3y 142 63 coronaviruses coronaviruse NNS cord-305859-vt8vwo3y 142 64 in in IN cord-305859-vt8vwo3y 142 65 the the DT cord-305859-vt8vwo3y 142 66 genus genus NN cord-305859-vt8vwo3y 142 67 deltacoronavirus deltacoronavirus NNP cord-305859-vt8vwo3y 142 68 supports support VBZ cord-305859-vt8vwo3y 142 69 bat bat NN cord-305859-vt8vwo3y 142 70 coronaviruses coronaviruse NNS cord-305859-vt8vwo3y 142 71 as as IN cord-305859-vt8vwo3y 142 72 the the DT cord-305859-vt8vwo3y 142 73 gene gene NN cord-305859-vt8vwo3y 142 74 source source NN cord-305859-vt8vwo3y 142 75 of of IN cord-305859-vt8vwo3y 142 76 alphacoronavirus alphacoronavirus NNP cord-305859-vt8vwo3y 142 77 and and CC cord-305859-vt8vwo3y 142 78 betacoronavirus betacoronavirus NNP cord-305859-vt8vwo3y 142 79 and and CC cord-305859-vt8vwo3y 142 80 avian avian JJ cord-305859-vt8vwo3y 142 81 coronaviruses coronaviruse NNS cord-305859-vt8vwo3y 142 82 as as IN cord-305859-vt8vwo3y 142 83 the the DT cord-305859-vt8vwo3y 142 84 gene gene NN cord-305859-vt8vwo3y 142 85 source source NN cord-305859-vt8vwo3y 142 86 of of IN cord-305859-vt8vwo3y 142 87 gammacoronavirus gammacoronavirus NNP cord-305859-vt8vwo3y 142 88 and and CC cord-305859-vt8vwo3y 142 89 deltacoronavirus deltacoronavirus JJ cord-305859-vt8vwo3y 142 90 Ethical ethical JJ cord-305859-vt8vwo3y 142 91 approval approval NN cord-305859-vt8vwo3y 143 1 All all DT cord-305859-vt8vwo3y 143 2 applicable applicable JJ cord-305859-vt8vwo3y 143 3 international international JJ cord-305859-vt8vwo3y 143 4 , , , cord-305859-vt8vwo3y 143 5 national national JJ cord-305859-vt8vwo3y 143 6 , , , cord-305859-vt8vwo3y 143 7 and/or and/or CC cord-305859-vt8vwo3y 143 8 institutional institutional JJ cord-305859-vt8vwo3y 143 9 guidelines guideline NNS cord-305859-vt8vwo3y 143 10 for for IN cord-305859-vt8vwo3y 143 11 the the DT cord-305859-vt8vwo3y 143 12 care care NN cord-305859-vt8vwo3y 143 13 and and CC cord-305859-vt8vwo3y 143 14 use use NN cord-305859-vt8vwo3y 143 15 of of IN cord-305859-vt8vwo3y 143 16 animals animal NNS cord-305859-vt8vwo3y 143 17 were be VBD cord-305859-vt8vwo3y 143 18 followed follow VBN cord-305859-vt8vwo3y 143 19 . . . cord-305859-vt8vwo3y 144 1 Conflict conflict NN cord-305859-vt8vwo3y 144 2 of of IN cord-305859-vt8vwo3y 144 3 interest interest NN cord-305859-vt8vwo3y 145 1 Neither neither DT cord-305859-vt8vwo3y 145 2 of of IN cord-305859-vt8vwo3y 145 3 the the DT cord-305859-vt8vwo3y 145 4 authors author NNS cord-305859-vt8vwo3y 145 5 of of IN cord-305859-vt8vwo3y 145 6 this this DT cord-305859-vt8vwo3y 145 7 paper paper NN cord-305859-vt8vwo3y 145 8 has have VBZ cord-305859-vt8vwo3y 145 9 a a DT cord-305859-vt8vwo3y 145 10 financial financial JJ cord-305859-vt8vwo3y 145 11 or or CC cord-305859-vt8vwo3y 145 12 personal personal JJ cord-305859-vt8vwo3y 145 13 relationship relationship NN cord-305859-vt8vwo3y 145 14 with with IN cord-305859-vt8vwo3y 145 15 other other JJ cord-305859-vt8vwo3y 145 16 people people NNS cord-305859-vt8vwo3y 145 17 or or CC cord-305859-vt8vwo3y 145 18 organizations organization NNS cord-305859-vt8vwo3y 145 19 that that WDT cord-305859-vt8vwo3y 145 20 could could MD cord-305859-vt8vwo3y 145 21 inappropriately inappropriately RB cord-305859-vt8vwo3y 145 22 influence influence VB cord-305859-vt8vwo3y 145 23 or or CC cord-305859-vt8vwo3y 145 24 bias bias VB cord-305859-vt8vwo3y 145 25 the the DT cord-305859-vt8vwo3y 145 26 content content NN cord-305859-vt8vwo3y 145 27 of of IN cord-305859-vt8vwo3y 145 28 the the DT cord-305859-vt8vwo3y 145 29 paper paper NN cord-305859-vt8vwo3y 145 30 . . . cord-305859-vt8vwo3y 146 1 All all DT cord-305859-vt8vwo3y 146 2 authors author NNS cord-305859-vt8vwo3y 146 3 have have VBP cord-305859-vt8vwo3y 146 4 seen see VBN cord-305859-vt8vwo3y 146 5 and and CC cord-305859-vt8vwo3y 146 6 approved approve VBN cord-305859-vt8vwo3y 146 7 the the DT cord-305859-vt8vwo3y 146 8 manuscript manuscript NN cord-305859-vt8vwo3y 146 9 . . .