id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306517-tls0849i	Leidenberger, S.	Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies	2017-09-07		.txt	text/plain	5929	325	56	To characterize the Central European PEDV strains regarding their virulence in suckling piglets, and to assess the protective effect of maternally derived antibodies (MDA), four trial groups were randomly assigned, each consisting of two pregnant sows and their litter. To induce MDA in a subset of piglets, two sows received a cell culture-adapted PEDV strain, and another two sows were inoculated with field material from German PED outbreaks. Subsequently, all piglets were inoculated with the corresponding PEDV strains at an age of 3 to 6 days, and virus shedding, clinical signs and occurrence of specific antibodies were assessed. Piglets without MDA and inoculated with the cell culture-adapted virus (PEDV EU, group A2) started vomiting 24 hours post inoculation (hpi), and showed diarrhea from 36 hpi. All sows, which were inoculated with PEDV prior to farrowing (groups A1 and B1), showed IgG isotype antibodies in blood and colostrum samples at the day of farrowing using the ELISA assays mentioned above.	./cache/cord-306517-tls0849i.txt	./txt/cord-306517-tls0849i.txt