id author title date pages extension mime words sentences flesch summary cache txt cord-287913-pe6ot11q Jung, Kwonil Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus 2007-06-18 .txt text/plain 2138 113 50 title: Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus Epidermal growth factor (EGF) promotes gastrointestinal mucosal recovery by stimulating the mitogenic activity of intestinal crypt epithelial cells. The aim of this study was to determine the effects of EGF on atrophic enteritis induced in piglets by experimental infection with porcine epidemic diarrhoea virus (PEDV) strain Dr13. EGF stimulates proliferation of intestinal crypt epithelial cells and promotes recovery from atrophic enteritis in PEDV-infected piglets. Most PEDV + EGF piglets had moderate diarrhoea from 24 to 36 hpi and severe diarrhoea Table 1 Mean ratio of villous height to crypt depth (VH:CD) in piglets infected with porcine epidemic diarrhoea virus with (PEDV + EGF) or without (PEDV only) epidermal growth factor relative to uninfected piglets (control) This study has shown that EGF enhances proliferation of intestinal crypt epithelial cells and promotes the recovery of damaged villi in piglets infected with PEDV. ./cache/cord-287913-pe6ot11q.txt ./txt/cord-287913-pe6ot11q.txt