id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252772-f3fctcru	Wang, Changlin	The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis	2020-05-22		.txt	text/plain	4956	295	54	Moreover, we demonstrated that PEDV escaped IFN-λ responses by substantially upregulating the suppressor of cytokine signaling protein 1 (SOCS1) expression, which impaired the induction of IFN-stimulated genes (ISGs) and dampened the IFN-λ antiviral response and facilitated PEDV replication in Vero E6 cells. Compared with a mock uninfected control, PEDV did not increase the expression of IFNλ transcripts as observed until 12 hpi, and then gradually induced IFN-λ expression, indicating that PEDV infection elicits type III IFN expression at the late stage of infection instead of the early stage of infection in the Vero E6 cells (Figure 1A) , which was consistent with the results in porcine enteroids (Li et al., 2019) . In the current study, we observed that PEDV elicited substantially increased IFN-λ expression in Vero E6 cells only after 24 hpi (Figure 1A) , which is consistent with the results observed in porcine enteroids following PEDV infection (Li et al., 2019) , indicating that PEDV has evolved mechanisms to escape IFN-λ antiviral response instead of IFN-λ production at the late stage of infection.	./cache/cord-252772-f3fctcru.txt	./txt/cord-252772-f3fctcru.txt