id sid tid token lemma pos cord-354035-i3sl2r0k 1 1 key key NN cord-354035-i3sl2r0k 1 2 : : : cord-354035-i3sl2r0k 2 1 cord-354035-i3sl2r0k cord-354035-i3sl2r0k JJ cord-354035-i3sl2r0k 3 1 authors author NNS cord-354035-i3sl2r0k 3 2 : : : cord-354035-i3sl2r0k 3 3 Wylie Wylie NNP cord-354035-i3sl2r0k 3 4 , , , cord-354035-i3sl2r0k 3 5 Kristine Kristine NNP cord-354035-i3sl2r0k 3 6 M. M. NNP cord-354035-i3sl2r0k 3 7 title title NN cord-354035-i3sl2r0k 3 8 : : : cord-354035-i3sl2r0k 3 9 The the DT cord-354035-i3sl2r0k 3 10 Virome Virome NNP cord-354035-i3sl2r0k 3 11 of of IN cord-354035-i3sl2r0k 3 12 the the DT cord-354035-i3sl2r0k 3 13 Human Human NNP cord-354035-i3sl2r0k 3 14 Respiratory Respiratory NNP cord-354035-i3sl2r0k 3 15 Tract Tract NNP cord-354035-i3sl2r0k 3 16 date date NN cord-354035-i3sl2r0k 3 17 : : : cord-354035-i3sl2r0k 3 18 2016 2016 CD cord-354035-i3sl2r0k 3 19 - - HYPH cord-354035-i3sl2r0k 3 20 12 12 CD cord-354035-i3sl2r0k 3 21 - - SYM cord-354035-i3sl2r0k 3 22 10 10 CD cord-354035-i3sl2r0k 3 23 journal journal NN cord-354035-i3sl2r0k 3 24 : : : cord-354035-i3sl2r0k 3 25 Clin Clin NNP cord-354035-i3sl2r0k 3 26 Chest Chest NNP cord-354035-i3sl2r0k 3 27 Med Med NNP cord-354035-i3sl2r0k 3 28 DOI doi NN cord-354035-i3sl2r0k 3 29 : : : cord-354035-i3sl2r0k 3 30 10.1016 10.1016 CD cord-354035-i3sl2r0k 3 31 / / SYM cord-354035-i3sl2r0k 3 32 j.ccm.2016.11.001 j.ccm.2016.11.001 NNP cord-354035-i3sl2r0k 3 33 sha sha NNP cord-354035-i3sl2r0k 3 34 : : : cord-354035-i3sl2r0k 3 35 728bb57647d56844e7d1bcce62e9452a1d171906 728bb57647d56844e7d1bcce62e9452a1d171906 CD cord-354035-i3sl2r0k 3 36 doc_id doc_id CD cord-354035-i3sl2r0k 3 37 : : : cord-354035-i3sl2r0k 3 38 354035 354035 CD cord-354035-i3sl2r0k 3 39 cord_uid cord_uid NNS cord-354035-i3sl2r0k 3 40 : : : cord-354035-i3sl2r0k 3 41 i3sl2r0k i3sl2r0k VBN cord-354035-i3sl2r0k 4 1 The the DT cord-354035-i3sl2r0k 4 2 human human JJ cord-354035-i3sl2r0k 4 3 respiratory respiratory JJ cord-354035-i3sl2r0k 4 4 tract tract NN cord-354035-i3sl2r0k 4 5 virome virome NNP cord-354035-i3sl2r0k 4 6 is be VBZ cord-354035-i3sl2r0k 4 7 defined define VBN cord-354035-i3sl2r0k 4 8 here here RB cord-354035-i3sl2r0k 4 9 as as IN cord-354035-i3sl2r0k 4 10 the the DT cord-354035-i3sl2r0k 4 11 viruses virus NNS cord-354035-i3sl2r0k 4 12 present present JJ cord-354035-i3sl2r0k 4 13 in in IN cord-354035-i3sl2r0k 4 14 the the DT cord-354035-i3sl2r0k 4 15 human human JJ cord-354035-i3sl2r0k 4 16 respiratory respiratory JJ cord-354035-i3sl2r0k 4 17 tract tract NN cord-354035-i3sl2r0k 4 18 that that WDT cord-354035-i3sl2r0k 4 19 can can MD cord-354035-i3sl2r0k 4 20 infect infect VB cord-354035-i3sl2r0k 4 21 human human JJ cord-354035-i3sl2r0k 4 22 cells cell NNS cord-354035-i3sl2r0k 4 23 . . . cord-354035-i3sl2r0k 5 1 Sensitive sensitive JJ cord-354035-i3sl2r0k 5 2 , , , cord-354035-i3sl2r0k 5 3 culture culture NN cord-354035-i3sl2r0k 5 4 - - HYPH cord-354035-i3sl2r0k 5 5 independent independent JJ cord-354035-i3sl2r0k 5 6 molecular molecular JJ cord-354035-i3sl2r0k 5 7 assays assay NNS cord-354035-i3sl2r0k 5 8 ( ( -LRB- cord-354035-i3sl2r0k 5 9 polymerase polymerase NN cord-354035-i3sl2r0k 5 10 chain chain NN cord-354035-i3sl2r0k 5 11 reaction reaction NN cord-354035-i3sl2r0k 5 12 and and CC cord-354035-i3sl2r0k 5 13 high high JJ cord-354035-i3sl2r0k 5 14 - - HYPH cord-354035-i3sl2r0k 5 15 throughput throughput NN cord-354035-i3sl2r0k 5 16 sequencing sequencing NN cord-354035-i3sl2r0k 5 17 ) ) -RRB- cord-354035-i3sl2r0k 5 18 reveal reveal VBP cord-354035-i3sl2r0k 5 19 that that IN cord-354035-i3sl2r0k 5 20 in in IN cord-354035-i3sl2r0k 5 21 addition addition NN cord-354035-i3sl2r0k 5 22 to to IN cord-354035-i3sl2r0k 5 23 common common JJ cord-354035-i3sl2r0k 5 24 viruses virus NNS cord-354035-i3sl2r0k 5 25 that that WDT cord-354035-i3sl2r0k 5 26 cause cause VBP cord-354035-i3sl2r0k 5 27 acute acute JJ cord-354035-i3sl2r0k 5 28 , , , cord-354035-i3sl2r0k 5 29 symptomatic symptomatic JJ cord-354035-i3sl2r0k 5 30 infections infection NNS cord-354035-i3sl2r0k 5 31 the the DT cord-354035-i3sl2r0k 5 32 virome virome NNP cord-354035-i3sl2r0k 5 33 also also RB cord-354035-i3sl2r0k 5 34 includes include VBZ cord-354035-i3sl2r0k 5 35 viruses virus NNS cord-354035-i3sl2r0k 5 36 that that WDT cord-354035-i3sl2r0k 5 37 do do VBP cord-354035-i3sl2r0k 5 38 not not RB cord-354035-i3sl2r0k 5 39 cause cause VB cord-354035-i3sl2r0k 5 40 clinical clinical JJ cord-354035-i3sl2r0k 5 41 symptoms symptom NNS cord-354035-i3sl2r0k 5 42 , , , cord-354035-i3sl2r0k 5 43 have have VBP cord-354035-i3sl2r0k 5 44 unknown unknown JJ cord-354035-i3sl2r0k 5 45 pathogenic pathogenic JJ cord-354035-i3sl2r0k 5 46 effect effect NN cord-354035-i3sl2r0k 5 47 , , , cord-354035-i3sl2r0k 5 48 or or CC cord-354035-i3sl2r0k 5 49 cause cause VB cord-354035-i3sl2r0k 5 50 symptoms symptom NNS cord-354035-i3sl2r0k 5 51 but but CC cord-354035-i3sl2r0k 5 52 are be VBP cord-354035-i3sl2r0k 5 53 not not RB cord-354035-i3sl2r0k 5 54 among among IN cord-354035-i3sl2r0k 5 55 the the DT cord-354035-i3sl2r0k 5 56 most most RBS cord-354035-i3sl2r0k 5 57 common common JJ cord-354035-i3sl2r0k 5 58 viral viral JJ cord-354035-i3sl2r0k 5 59 respiratory respiratory JJ cord-354035-i3sl2r0k 5 60 tract tract NN cord-354035-i3sl2r0k 5 61 pathogens pathogen NNS cord-354035-i3sl2r0k 5 62 . . . cord-354035-i3sl2r0k 6 1 These these DT cord-354035-i3sl2r0k 6 2 molecular molecular JJ cord-354035-i3sl2r0k 6 3 tools tool NNS cord-354035-i3sl2r0k 6 4 provide provide VBP cord-354035-i3sl2r0k 6 5 means mean NNS cord-354035-i3sl2r0k 6 6 for for IN cord-354035-i3sl2r0k 6 7 better well RBR cord-354035-i3sl2r0k 6 8 defining define VBG cord-354035-i3sl2r0k 6 9 the the DT cord-354035-i3sl2r0k 6 10 virome virome NN cord-354035-i3sl2r0k 6 11 and and CC cord-354035-i3sl2r0k 6 12 studying study VBG cord-354035-i3sl2r0k 6 13 the the DT cord-354035-i3sl2r0k 6 14 effects effect NNS cord-354035-i3sl2r0k 6 15 of of IN cord-354035-i3sl2r0k 6 16 viral viral JJ cord-354035-i3sl2r0k 6 17 infections infection NNS cord-354035-i3sl2r0k 6 18 on on IN cord-354035-i3sl2r0k 6 19 the the DT cord-354035-i3sl2r0k 6 20 dynamics dynamic NNS cord-354035-i3sl2r0k 6 21 of of IN cord-354035-i3sl2r0k 6 22 chronic chronic JJ cord-354035-i3sl2r0k 6 23 lung lung NN cord-354035-i3sl2r0k 6 24 diseases disease NNS cord-354035-i3sl2r0k 6 25 . . . cord-354035-i3sl2r0k 7 1 Viral viral JJ cord-354035-i3sl2r0k 7 2 infections infection NNS cord-354035-i3sl2r0k 7 3 of of IN cord-354035-i3sl2r0k 7 4 the the DT cord-354035-i3sl2r0k 7 5 respiratory respiratory JJ cord-354035-i3sl2r0k 7 6 tract tract NN cord-354035-i3sl2r0k 7 7 are be VBP cord-354035-i3sl2r0k 7 8 very very RB cord-354035-i3sl2r0k 7 9 common common JJ cord-354035-i3sl2r0k 7 10 . . . cord-354035-i3sl2r0k 8 1 In in IN cord-354035-i3sl2r0k 8 2 a a DT cord-354035-i3sl2r0k 8 3 recent recent JJ cord-354035-i3sl2r0k 8 4 study study NN cord-354035-i3sl2r0k 8 5 of of IN cord-354035-i3sl2r0k 8 6 26 26 CD cord-354035-i3sl2r0k 8 7 households household NNS cord-354035-i3sl2r0k 8 8 in in IN cord-354035-i3sl2r0k 8 9 Utah Utah NNP cord-354035-i3sl2r0k 8 10 that that WDT cord-354035-i3sl2r0k 8 11 were be VBD cord-354035-i3sl2r0k 8 12 followed follow VBN cord-354035-i3sl2r0k 8 13 weekly weekly RB cord-354035-i3sl2r0k 8 14 over over IN cord-354035-i3sl2r0k 8 15 1 1 CD cord-354035-i3sl2r0k 8 16 year year NN cord-354035-i3sl2r0k 8 17 , , , cord-354035-i3sl2r0k 8 18 modern modern JJ cord-354035-i3sl2r0k 8 19 molecular molecular JJ cord-354035-i3sl2r0k 8 20 methods method NNS cord-354035-i3sl2r0k 8 21 were be VBD cord-354035-i3sl2r0k 8 22 used use VBN cord-354035-i3sl2r0k 8 23 to to TO cord-354035-i3sl2r0k 8 24 detect detect VB cord-354035-i3sl2r0k 8 25 respiratory respiratory JJ cord-354035-i3sl2r0k 8 26 viruses virus NNS cord-354035-i3sl2r0k 8 27 in in IN cord-354035-i3sl2r0k 8 28 the the DT cord-354035-i3sl2r0k 8 29 anterior anterior JJ cord-354035-i3sl2r0k 8 30 nares naris NNS cord-354035-i3sl2r0k 8 31 . . . cord-354035-i3sl2r0k 9 1 1 1 LS cord-354035-i3sl2r0k 10 1 This this DT cord-354035-i3sl2r0k 10 2 study study NN cord-354035-i3sl2r0k 10 3 found find VBD cord-354035-i3sl2r0k 10 4 that that IN cord-354035-i3sl2r0k 10 5 children child NNS cord-354035-i3sl2r0k 10 6 less less JJR cord-354035-i3sl2r0k 10 7 than than IN cord-354035-i3sl2r0k 10 8 5 5 CD cord-354035-i3sl2r0k 10 9 years year NNS cord-354035-i3sl2r0k 10 10 old old JJ cord-354035-i3sl2r0k 10 11 had have VBD cord-354035-i3sl2r0k 10 12 about about RB cord-354035-i3sl2r0k 10 13 12 12 CD cord-354035-i3sl2r0k 10 14 viral viral JJ cord-354035-i3sl2r0k 10 15 episodes episode NNS cord-354035-i3sl2r0k 10 16 in in IN cord-354035-i3sl2r0k 10 17 the the DT cord-354035-i3sl2r0k 10 18 respiratory respiratory JJ cord-354035-i3sl2r0k 10 19 tract tract NN cord-354035-i3sl2r0k 10 20 each each DT cord-354035-i3sl2r0k 10 21 year year NN cord-354035-i3sl2r0k 10 22 , , , cord-354035-i3sl2r0k 10 23 whereas whereas IN cord-354035-i3sl2r0k 10 24 adults adult NNS cord-354035-i3sl2r0k 10 25 averaged average VBD cord-354035-i3sl2r0k 10 26 about about RB cord-354035-i3sl2r0k 10 27 6 6 CD cord-354035-i3sl2r0k 10 28 per per IN cord-354035-i3sl2r0k 10 29 year year NN cord-354035-i3sl2r0k 10 30 . . . cord-354035-i3sl2r0k 11 1 These these DT cord-354035-i3sl2r0k 11 2 numbers number NNS cord-354035-i3sl2r0k 11 3 are be VBP cord-354035-i3sl2r0k 11 4 higher high JJR cord-354035-i3sl2r0k 11 5 than than IN cord-354035-i3sl2r0k 11 6 previous previous JJ cord-354035-i3sl2r0k 11 7 studies study NNS cord-354035-i3sl2r0k 11 8 , , , cord-354035-i3sl2r0k 11 9 2 2 CD cord-354035-i3sl2r0k 11 10 which which WDT cord-354035-i3sl2r0k 11 11 is be VBZ cord-354035-i3sl2r0k 11 12 likely likely RB cord-354035-i3sl2r0k 11 13 explained explain VBN cord-354035-i3sl2r0k 11 14 by by IN cord-354035-i3sl2r0k 11 15 the the DT cord-354035-i3sl2r0k 11 16 use use NN cord-354035-i3sl2r0k 11 17 of of IN cord-354035-i3sl2r0k 11 18 molecular molecular JJ cord-354035-i3sl2r0k 11 19 assays assay NNS cord-354035-i3sl2r0k 11 20 instead instead RB cord-354035-i3sl2r0k 11 21 of of IN cord-354035-i3sl2r0k 11 22 culture culture NN cord-354035-i3sl2r0k 11 23 - - HYPH cord-354035-i3sl2r0k 11 24 and and CC cord-354035-i3sl2r0k 11 25 serology serology NN cord-354035-i3sl2r0k 11 26 - - HYPH cord-354035-i3sl2r0k 11 27 based base VBN cord-354035-i3sl2r0k 11 28 tests test NNS cord-354035-i3sl2r0k 11 29 and and CC cord-354035-i3sl2r0k 11 30 the the DT cord-354035-i3sl2r0k 11 31 discovery discovery NN cord-354035-i3sl2r0k 11 32 of of IN cord-354035-i3sl2r0k 11 33 new new JJ cord-354035-i3sl2r0k 11 34 respiratory respiratory JJ cord-354035-i3sl2r0k 11 35 viruses virus NNS cord-354035-i3sl2r0k 11 36 in in IN cord-354035-i3sl2r0k 11 37 intervening intervene VBG cord-354035-i3sl2r0k 11 38 years year NNS cord-354035-i3sl2r0k 11 39 that that WDT cord-354035-i3sl2r0k 11 40 would would MD cord-354035-i3sl2r0k 11 41 not not RB cord-354035-i3sl2r0k 11 42 have have VB cord-354035-i3sl2r0k 11 43 been be VBN cord-354035-i3sl2r0k 11 44 assessed assess VBN cord-354035-i3sl2r0k 11 45 in in IN cord-354035-i3sl2r0k 11 46 older old JJR cord-354035-i3sl2r0k 11 47 studies study NNS cord-354035-i3sl2r0k 11 48 . . . cord-354035-i3sl2r0k 12 1 Modern modern JJ cord-354035-i3sl2r0k 12 2 molecular molecular JJ cord-354035-i3sl2r0k 12 3 methods method NNS cord-354035-i3sl2r0k 12 4 for for IN cord-354035-i3sl2r0k 12 5 virus virus NN cord-354035-i3sl2r0k 12 6 detection detection NN cord-354035-i3sl2r0k 12 7 are be VBP cord-354035-i3sl2r0k 12 8 highly highly RB cord-354035-i3sl2r0k 12 9 sensitive sensitive JJ cord-354035-i3sl2r0k 12 10 and and CC cord-354035-i3sl2r0k 12 11 specific specific JJ cord-354035-i3sl2r0k 12 12 . . . cord-354035-i3sl2r0k 13 1 Polymerase polymerase NN cord-354035-i3sl2r0k 13 2 chain chain NN cord-354035-i3sl2r0k 13 3 reaction reaction NN cord-354035-i3sl2r0k 13 4 ( ( -LRB- cord-354035-i3sl2r0k 13 5 PCR PCR NNP cord-354035-i3sl2r0k 13 6 ) ) -RRB- cord-354035-i3sl2r0k 13 7 assays assay NNS cord-354035-i3sl2r0k 13 8 are be VBP cord-354035-i3sl2r0k 13 9 also also RB cord-354035-i3sl2r0k 13 10 rapid rapid JJ cord-354035-i3sl2r0k 13 11 and and CC cord-354035-i3sl2r0k 13 12 generally generally RB cord-354035-i3sl2r0k 13 13 inexpensive inexpensive JJ cord-354035-i3sl2r0k 13 14 . . . cord-354035-i3sl2r0k 14 1 High high JJ cord-354035-i3sl2r0k 14 2 - - HYPH cord-354035-i3sl2r0k 14 3 throughput throughput NN cord-354035-i3sl2r0k 14 4 nucleic nucleic JJ cord-354035-i3sl2r0k 14 5 acid acid NN cord-354035-i3sl2r0k 14 6 sequencing sequencing NN cord-354035-i3sl2r0k 14 7 ( ( -LRB- cord-354035-i3sl2r0k 14 8 HTS HTS NNP cord-354035-i3sl2r0k 14 9 ) ) -RRB- cord-354035-i3sl2r0k 14 10 methods method NNS cord-354035-i3sl2r0k 14 11 are be VBP cord-354035-i3sl2r0k 14 12 slower slow JJR cord-354035-i3sl2r0k 14 13 but but CC cord-354035-i3sl2r0k 14 14 have have VBP cord-354035-i3sl2r0k 14 15 the the DT cord-354035-i3sl2r0k 14 16 potential potential NN cord-354035-i3sl2r0k 14 17 to to TO cord-354035-i3sl2r0k 14 18 be be VB cord-354035-i3sl2r0k 14 19 more more RBR cord-354035-i3sl2r0k 14 20 comprehensive comprehensive JJ cord-354035-i3sl2r0k 14 21 because because IN cord-354035-i3sl2r0k 14 22 there there EX cord-354035-i3sl2r0k 14 23 is be VBZ cord-354035-i3sl2r0k 14 24 no no DT cord-354035-i3sl2r0k 14 25 need need NN cord-354035-i3sl2r0k 14 26 to to TO cord-354035-i3sl2r0k 14 27 select select VB cord-354035-i3sl2r0k 14 28 specific specific JJ cord-354035-i3sl2r0k 14 29 targets target NNS cord-354035-i3sl2r0k 14 30 beforehand beforehand RB cord-354035-i3sl2r0k 14 31 , , , cord-354035-i3sl2r0k 14 32 and and CC cord-354035-i3sl2r0k 14 33 the the DT cord-354035-i3sl2r0k 14 34 method method NN cord-354035-i3sl2r0k 14 35 can can MD cord-354035-i3sl2r0k 14 36 detect detect VB cord-354035-i3sl2r0k 14 37 genomes genome NNS cord-354035-i3sl2r0k 14 38 with with IN cord-354035-i3sl2r0k 14 39 substantial substantial JJ cord-354035-i3sl2r0k 14 40 sequence sequence NN cord-354035-i3sl2r0k 14 41 variation variation NN cord-354035-i3sl2r0k 14 42 compared compare VBN cord-354035-i3sl2r0k 14 43 with with IN cord-354035-i3sl2r0k 14 44 known know VBN cord-354035-i3sl2r0k 14 45 reference reference NN cord-354035-i3sl2r0k 14 46 genomes genome NNS cord-354035-i3sl2r0k 14 47 ( ( -LRB- cord-354035-i3sl2r0k 14 48 Fig fig NN cord-354035-i3sl2r0k 14 49 . . NNP cord-354035-i3sl2r0k 14 50 1 1 CD cord-354035-i3sl2r0k 14 51 ) ) -RRB- cord-354035-i3sl2r0k 14 52 . . . cord-354035-i3sl2r0k 15 1 With with IN cord-354035-i3sl2r0k 15 2 these these DT cord-354035-i3sl2r0k 15 3 tools tool NNS cord-354035-i3sl2r0k 15 4 in in IN cord-354035-i3sl2r0k 15 5 hand hand NN cord-354035-i3sl2r0k 15 6 , , , cord-354035-i3sl2r0k 15 7 we -PRON- PRP cord-354035-i3sl2r0k 15 8 can can MD cord-354035-i3sl2r0k 15 9 begin begin VB cord-354035-i3sl2r0k 15 10 to to TO cord-354035-i3sl2r0k 15 11 think think VB cord-354035-i3sl2r0k 15 12 about about IN cord-354035-i3sl2r0k 15 13 characterizing characterize VBG cord-354035-i3sl2r0k 15 14 the the DT cord-354035-i3sl2r0k 15 15 virome virome NN cord-354035-i3sl2r0k 15 16 of of IN cord-354035-i3sl2r0k 15 17 the the DT cord-354035-i3sl2r0k 15 18 respiratory respiratory JJ cord-354035-i3sl2r0k 15 19 tract tract NN cord-354035-i3sl2r0k 15 20 , , , cord-354035-i3sl2r0k 15 21 herein herein RB cord-354035-i3sl2r0k 15 22 defined define VBN cord-354035-i3sl2r0k 15 23 as as IN cord-354035-i3sl2r0k 15 24 all all DT cord-354035-i3sl2r0k 15 25 of of IN cord-354035-i3sl2r0k 15 26 the the DT cord-354035-i3sl2r0k 15 27 viruses virus NNS cord-354035-i3sl2r0k 15 28 in in IN cord-354035-i3sl2r0k 15 29 the the DT cord-354035-i3sl2r0k 15 30 respiratory respiratory JJ cord-354035-i3sl2r0k 15 31 tract tract NN cord-354035-i3sl2r0k 15 32 that that WDT cord-354035-i3sl2r0k 15 33 can can MD cord-354035-i3sl2r0k 15 34 infect infect VB cord-354035-i3sl2r0k 15 35 and and CC cord-354035-i3sl2r0k 15 36 replicate replicate VB cord-354035-i3sl2r0k 15 37 in in IN cord-354035-i3sl2r0k 15 38 human human JJ cord-354035-i3sl2r0k 15 39 cells cell NNS cord-354035-i3sl2r0k 15 40 , , , cord-354035-i3sl2r0k 15 41 which which WDT cord-354035-i3sl2r0k 15 42 includes include VBZ cord-354035-i3sl2r0k 15 43 known know VBN cord-354035-i3sl2r0k 15 44 pathogens pathogen NNS cord-354035-i3sl2r0k 15 45 and and CC cord-354035-i3sl2r0k 15 46 viruses virus NNS cord-354035-i3sl2r0k 15 47 with with IN cord-354035-i3sl2r0k 15 48 unknown unknown JJ cord-354035-i3sl2r0k 15 49 pathogenicity pathogenicity NN cord-354035-i3sl2r0k 15 50 . . . cord-354035-i3sl2r0k 16 1 We -PRON- PRP cord-354035-i3sl2r0k 16 2 have have VBP cord-354035-i3sl2r0k 16 3 begun begin VBN cord-354035-i3sl2r0k 16 4 to to TO cord-354035-i3sl2r0k 16 5 learn learn VB cord-354035-i3sl2r0k 16 6 about about IN cord-354035-i3sl2r0k 16 7 the the DT cord-354035-i3sl2r0k 16 8 virome virome NN cord-354035-i3sl2r0k 16 9 of of IN cord-354035-i3sl2r0k 16 10 the the DT cord-354035-i3sl2r0k 16 11 respiratory respiratory JJ cord-354035-i3sl2r0k 16 12 tract tract NN cord-354035-i3sl2r0k 16 13 through through IN cord-354035-i3sl2r0k 16 14 studies study NNS cord-354035-i3sl2r0k 16 15 of of IN cord-354035-i3sl2r0k 16 16 patients patient NNS cord-354035-i3sl2r0k 16 17 with with IN cord-354035-i3sl2r0k 16 18 acute acute JJ cord-354035-i3sl2r0k 16 19 infections infection NNS cord-354035-i3sl2r0k 16 20 , , , cord-354035-i3sl2r0k 16 21 chronic chronic JJ cord-354035-i3sl2r0k 16 22 lung lung NN cord-354035-i3sl2r0k 16 23 diseases disease NNS cord-354035-i3sl2r0k 16 24 , , , cord-354035-i3sl2r0k 16 25 and and CC cord-354035-i3sl2r0k 16 26 undergoing undergo VBG cord-354035-i3sl2r0k 16 27 lung lung NN cord-354035-i3sl2r0k 16 28 transplantation transplantation NN cord-354035-i3sl2r0k 16 29 , , , cord-354035-i3sl2r0k 16 30 among among IN cord-354035-i3sl2r0k 16 31 others other NNS cord-354035-i3sl2r0k 16 32 . . . cord-354035-i3sl2r0k 17 1 The the DT cord-354035-i3sl2r0k 17 2 author author NN cord-354035-i3sl2r0k 17 3 reviews review VBZ cord-354035-i3sl2r0k 17 4 some some DT cord-354035-i3sl2r0k 17 5 of of IN cord-354035-i3sl2r0k 17 6 these these DT cord-354035-i3sl2r0k 17 7 studies study NNS cord-354035-i3sl2r0k 17 8 in in IN cord-354035-i3sl2r0k 17 9 addition addition NN cord-354035-i3sl2r0k 17 10 to to IN cord-354035-i3sl2r0k 17 11 recent recent JJ cord-354035-i3sl2r0k 17 12 technological technological JJ cord-354035-i3sl2r0k 17 13 developments development NNS cord-354035-i3sl2r0k 17 14 , , , cord-354035-i3sl2r0k 17 15 which which WDT cord-354035-i3sl2r0k 17 16 will will MD cord-354035-i3sl2r0k 17 17 improve improve VB cord-354035-i3sl2r0k 17 18 characterization characterization NN cord-354035-i3sl2r0k 17 19 of of IN cord-354035-i3sl2r0k 17 20 the the DT cord-354035-i3sl2r0k 17 21 respiratory respiratory JJ cord-354035-i3sl2r0k 17 22 virome virome NN cord-354035-i3sl2r0k 17 23 and and CC cord-354035-i3sl2r0k 17 24 diagnostics diagnostic NNS cord-354035-i3sl2r0k 17 25 in in IN cord-354035-i3sl2r0k 17 26 coming come VBG cord-354035-i3sl2r0k 17 27 years year NNS cord-354035-i3sl2r0k 17 28 . . . cord-354035-i3sl2r0k 18 1 Defining define VBG cord-354035-i3sl2r0k 18 2 the the DT cord-354035-i3sl2r0k 18 3 virome virome NN cord-354035-i3sl2r0k 18 4 in in IN cord-354035-i3sl2r0k 18 5 the the DT cord-354035-i3sl2r0k 18 6 respiratory respiratory JJ cord-354035-i3sl2r0k 18 7 tract tract NN cord-354035-i3sl2r0k 18 8 and and CC cord-354035-i3sl2r0k 18 9 understanding understand VBG cord-354035-i3sl2r0k 18 10 the the DT cord-354035-i3sl2r0k 18 11 implications implication NNS cord-354035-i3sl2r0k 18 12 of of IN cord-354035-i3sl2r0k 18 13 the the DT cord-354035-i3sl2r0k 18 14 viruses virus NNS cord-354035-i3sl2r0k 18 15 detected detect VBN cord-354035-i3sl2r0k 18 16 are be VBP cord-354035-i3sl2r0k 18 17 significant significant JJ cord-354035-i3sl2r0k 18 18 challenges challenge NNS cord-354035-i3sl2r0k 18 19 . . . cord-354035-i3sl2r0k 19 1 The the DT cord-354035-i3sl2r0k 19 2 work work NN cord-354035-i3sl2r0k 19 3 is be VBZ cord-354035-i3sl2r0k 19 4 complicated complicate VBN cord-354035-i3sl2r0k 19 5 by by IN cord-354035-i3sl2r0k 19 6 several several JJ cord-354035-i3sl2r0k 19 7 factors factor NNS cord-354035-i3sl2r0k 19 8 . . . cord-354035-i3sl2r0k 20 1 First first RB cord-354035-i3sl2r0k 20 2 , , , cord-354035-i3sl2r0k 20 3 the the DT cord-354035-i3sl2r0k 20 4 lower low JJR cord-354035-i3sl2r0k 20 5 airway airway NN cord-354035-i3sl2r0k 20 6 is be VBZ cord-354035-i3sl2r0k 20 7 not not RB cord-354035-i3sl2r0k 20 8 easily easily RB cord-354035-i3sl2r0k 20 9 accessible accessible JJ cord-354035-i3sl2r0k 20 10 and and CC cord-354035-i3sl2r0k 20 11 sometimes sometimes RB cord-354035-i3sl2r0k 20 12 requires require VBZ cord-354035-i3sl2r0k 20 13 invasive invasive JJ cord-354035-i3sl2r0k 20 14 sampling sampling NN cord-354035-i3sl2r0k 20 15 . . . cord-354035-i3sl2r0k 21 1 For for IN cord-354035-i3sl2r0k 21 2 instance instance NN cord-354035-i3sl2r0k 21 3 , , , cord-354035-i3sl2r0k 21 4 bronchoalveolar bronchoalveolar NNP cord-354035-i3sl2r0k 21 5 lavage lavage NN cord-354035-i3sl2r0k 21 6 samples sample NNS cord-354035-i3sl2r0k 21 7 are be VBP cord-354035-i3sl2r0k 21 8 often often RB cord-354035-i3sl2r0k 21 9 only only RB cord-354035-i3sl2r0k 21 10 available available JJ cord-354035-i3sl2r0k 21 11 from from IN cord-354035-i3sl2r0k 21 12 symptomatic symptomatic JJ cord-354035-i3sl2r0k 21 13 individuals individual NNS cord-354035-i3sl2r0k 21 14 who who WP cord-354035-i3sl2r0k 21 15 are be VBP cord-354035-i3sl2r0k 21 16 having have VBG cord-354035-i3sl2r0k 21 17 lavage lavage NN cord-354035-i3sl2r0k 21 18 performed perform VBN cord-354035-i3sl2r0k 21 19 for for IN cord-354035-i3sl2r0k 21 20 diagnostic diagnostic JJ cord-354035-i3sl2r0k 21 21 testing testing NN cord-354035-i3sl2r0k 21 22 and and CC cord-354035-i3sl2r0k 21 23 not not RB cord-354035-i3sl2r0k 21 24 from from IN cord-354035-i3sl2r0k 21 25 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 21 26 controls control NNS cord-354035-i3sl2r0k 21 27 . . . cord-354035-i3sl2r0k 22 1 Second second RB cord-354035-i3sl2r0k 22 2 , , , cord-354035-i3sl2r0k 22 3 a a DT cord-354035-i3sl2r0k 22 4 study study NN cord-354035-i3sl2r0k 22 5 of of IN cord-354035-i3sl2r0k 22 6 the the DT cord-354035-i3sl2r0k 22 7 viruses virus NNS cord-354035-i3sl2r0k 22 8 in in IN cord-354035-i3sl2r0k 22 9 the the DT cord-354035-i3sl2r0k 22 10 lungs lung NNS cord-354035-i3sl2r0k 22 11 of of IN cord-354035-i3sl2r0k 22 12 patients patient NNS cord-354035-i3sl2r0k 22 13 with with IN cord-354035-i3sl2r0k 22 14 cystic cystic JJ cord-354035-i3sl2r0k 22 15 fibrosis fibrosis NN cord-354035-i3sl2r0k 22 16 ( ( -LRB- cord-354035-i3sl2r0k 22 17 CF CF NNP cord-354035-i3sl2r0k 22 18 ) ) -RRB- cord-354035-i3sl2r0k 22 19 showed show VBD cord-354035-i3sl2r0k 22 20 that that IN cord-354035-i3sl2r0k 22 21 the the DT cord-354035-i3sl2r0k 22 22 viral viral JJ cord-354035-i3sl2r0k 22 23 populations population NNS cord-354035-i3sl2r0k 22 24 were be VBD cord-354035-i3sl2r0k 22 25 distinct distinct JJ cord-354035-i3sl2r0k 22 26 in in IN cord-354035-i3sl2r0k 22 27 different different JJ cord-354035-i3sl2r0k 22 28 regions region NNS cord-354035-i3sl2r0k 22 29 of of IN cord-354035-i3sl2r0k 22 30 the the DT cord-354035-i3sl2r0k 22 31 lung lung NN cord-354035-i3sl2r0k 22 32 . . . cord-354035-i3sl2r0k 23 1 3 3 LS cord-354035-i3sl2r0k 24 1 This this DT cord-354035-i3sl2r0k 24 2 variation variation NN cord-354035-i3sl2r0k 24 3 within within IN cord-354035-i3sl2r0k 24 4 the the DT cord-354035-i3sl2r0k 24 5 respiratory respiratory JJ cord-354035-i3sl2r0k 24 6 tract tract NN cord-354035-i3sl2r0k 24 7 and and CC cord-354035-i3sl2r0k 24 8 lung lung NN cord-354035-i3sl2r0k 24 9 means mean VBZ cord-354035-i3sl2r0k 24 10 it -PRON- PRP cord-354035-i3sl2r0k 24 11 can can MD cord-354035-i3sl2r0k 24 12 be be VB cord-354035-i3sl2r0k 24 13 difficult difficult JJ cord-354035-i3sl2r0k 24 14 to to TO cord-354035-i3sl2r0k 24 15 get get VB cord-354035-i3sl2r0k 24 16 a a DT cord-354035-i3sl2r0k 24 17 clear clear JJ cord-354035-i3sl2r0k 24 18 , , , cord-354035-i3sl2r0k 24 19 or or CC cord-354035-i3sl2r0k 24 20 complete complete JJ cord-354035-i3sl2r0k 24 21 , , , cord-354035-i3sl2r0k 24 22 view view NN cord-354035-i3sl2r0k 24 23 of of IN cord-354035-i3sl2r0k 24 24 the the DT cord-354035-i3sl2r0k 24 25 virome virome NN cord-354035-i3sl2r0k 24 26 . . . cord-354035-i3sl2r0k 25 1 Third third RB cord-354035-i3sl2r0k 25 2 , , , cord-354035-i3sl2r0k 25 3 only only RB cord-354035-i3sl2r0k 25 4 recently recently RB cord-354035-i3sl2r0k 25 5 have have VBP cord-354035-i3sl2r0k 25 6 relatively relatively RB cord-354035-i3sl2r0k 25 7 unbiased unbiased JJ cord-354035-i3sl2r0k 25 8 approaches approach NNS cord-354035-i3sl2r0k 25 9 to to IN cord-354035-i3sl2r0k 25 10 identifying identify VBG cord-354035-i3sl2r0k 25 11 viruses virus NNS cord-354035-i3sl2r0k 25 12 become become VBN cord-354035-i3sl2r0k 25 13 available available JJ cord-354035-i3sl2r0k 25 14 in in IN cord-354035-i3sl2r0k 25 15 the the DT cord-354035-i3sl2r0k 25 16 form form NN cord-354035-i3sl2r0k 25 17 of of IN cord-354035-i3sl2r0k 25 18 HTS HTS NNP cord-354035-i3sl2r0k 25 19 assays assay NNS cord-354035-i3sl2r0k 25 20 . . . cord-354035-i3sl2r0k 26 1 With with IN cord-354035-i3sl2r0k 26 2 that that DT cord-354035-i3sl2r0k 26 3 said say VBD cord-354035-i3sl2r0k 26 4 , , , cord-354035-i3sl2r0k 26 5 a a DT cord-354035-i3sl2r0k 26 6 great great JJ cord-354035-i3sl2r0k 26 7 deal deal NN cord-354035-i3sl2r0k 26 8 of of IN cord-354035-i3sl2r0k 26 9 progress progress NN cord-354035-i3sl2r0k 26 10 has have VBZ cord-354035-i3sl2r0k 26 11 been be VBN cord-354035-i3sl2r0k 26 12 made make VBN cord-354035-i3sl2r0k 26 13 in in IN cord-354035-i3sl2r0k 26 14 defining define VBG cord-354035-i3sl2r0k 26 15 the the DT cord-354035-i3sl2r0k 26 16 human human JJ cord-354035-i3sl2r0k 26 17 virome virome NN cord-354035-i3sl2r0k 26 18 in in IN cord-354035-i3sl2r0k 26 19 the the DT cord-354035-i3sl2r0k 26 20 respiratory respiratory JJ cord-354035-i3sl2r0k 26 21 tract tract NN cord-354035-i3sl2r0k 26 22 ( ( -LRB- cord-354035-i3sl2r0k 26 23 summarized summarize VBN cord-354035-i3sl2r0k 26 24 in in IN cord-354035-i3sl2r0k 26 25 Table Table NNP cord-354035-i3sl2r0k 26 26 1 1 CD cord-354035-i3sl2r0k 26 27 ) ) -RRB- cord-354035-i3sl2r0k 26 28 . . . cord-354035-i3sl2r0k 27 1 One one CD cord-354035-i3sl2r0k 27 2 cost cost NN cord-354035-i3sl2r0k 27 3 - - HYPH cord-354035-i3sl2r0k 27 4 effective effective JJ cord-354035-i3sl2r0k 27 5 approach approach NN cord-354035-i3sl2r0k 27 6 to to TO cord-354035-i3sl2r0k 27 7 broadly broadly RB cord-354035-i3sl2r0k 27 8 identify identify VB cord-354035-i3sl2r0k 27 9 viruses virus NNS cord-354035-i3sl2r0k 27 10 associated associate VBN cord-354035-i3sl2r0k 27 11 with with IN cord-354035-i3sl2r0k 27 12 the the DT cord-354035-i3sl2r0k 27 13 respiratory respiratory JJ cord-354035-i3sl2r0k 27 14 tract tract NN cord-354035-i3sl2r0k 27 15 is be VBZ cord-354035-i3sl2r0k 27 16 to to IN cord-354035-i3sl2r0k 27 17 pool pool NN cord-354035-i3sl2r0k 27 18 samples sample NNS cord-354035-i3sl2r0k 27 19 and and CC cord-354035-i3sl2r0k 27 20 screen screen NN cord-354035-i3sl2r0k 27 21 for for IN cord-354035-i3sl2r0k 27 22 a a DT cord-354035-i3sl2r0k 27 23 comprehensive comprehensive JJ cord-354035-i3sl2r0k 27 24 set set NN cord-354035-i3sl2r0k 27 25 of of IN cord-354035-i3sl2r0k 27 26 viruses virus NNS cord-354035-i3sl2r0k 27 27 . . . cord-354035-i3sl2r0k 28 1 The the DT cord-354035-i3sl2r0k 28 2 downside downside NN cord-354035-i3sl2r0k 28 3 to to IN cord-354035-i3sl2r0k 28 4 this this DT cord-354035-i3sl2r0k 28 5 approach approach NN cord-354035-i3sl2r0k 28 6 is be VBZ cord-354035-i3sl2r0k 28 7 that that IN cord-354035-i3sl2r0k 28 8 one one PRP cord-354035-i3sl2r0k 28 9 can can MD cord-354035-i3sl2r0k 28 10 not not RB cord-354035-i3sl2r0k 28 11 determine determine VB cord-354035-i3sl2r0k 28 12 the the DT cord-354035-i3sl2r0k 28 13 frequency frequency NN cord-354035-i3sl2r0k 28 14 at at IN cord-354035-i3sl2r0k 28 15 which which WDT cord-354035-i3sl2r0k 28 16 any any DT cord-354035-i3sl2r0k 28 17 individual individual JJ cord-354035-i3sl2r0k 28 18 virus virus NN cord-354035-i3sl2r0k 28 19 occurs occur VBZ cord-354035-i3sl2r0k 28 20 among among IN cord-354035-i3sl2r0k 28 21 patients patient NNS cord-354035-i3sl2r0k 28 22 . . . cord-354035-i3sl2r0k 29 1 However however RB cord-354035-i3sl2r0k 29 2 , , , cord-354035-i3sl2r0k 29 3 as as IN cord-354035-i3sl2r0k 29 4 characterization characterization NN cord-354035-i3sl2r0k 29 5 of of IN cord-354035-i3sl2r0k 29 6 the the DT cord-354035-i3sl2r0k 29 7 respiratory respiratory JJ cord-354035-i3sl2r0k 29 8 tract tract NN cord-354035-i3sl2r0k 29 9 virome virome NN cord-354035-i3sl2r0k 29 10 using use VBG cord-354035-i3sl2r0k 29 11 molecular molecular JJ cord-354035-i3sl2r0k 29 12 methods method NNS cord-354035-i3sl2r0k 29 13 is be VBZ cord-354035-i3sl2r0k 29 14 a a DT cord-354035-i3sl2r0k 29 15 relatively relatively RB cord-354035-i3sl2r0k 29 16 new new JJ cord-354035-i3sl2r0k 29 17 area area NN cord-354035-i3sl2r0k 29 18 of of IN cord-354035-i3sl2r0k 29 19 exploration exploration NN cord-354035-i3sl2r0k 29 20 , , , cord-354035-i3sl2r0k 29 21 these these DT cord-354035-i3sl2r0k 29 22 studies study NNS cord-354035-i3sl2r0k 29 23 can can MD cord-354035-i3sl2r0k 29 24 be be VB cord-354035-i3sl2r0k 29 25 useful useful JJ cord-354035-i3sl2r0k 29 26 in in IN cord-354035-i3sl2r0k 29 27 order order NN cord-354035-i3sl2r0k 29 28 to to TO cord-354035-i3sl2r0k 29 29 determine determine VB cord-354035-i3sl2r0k 29 30 if if IN cord-354035-i3sl2r0k 29 31 viruses virus NNS cord-354035-i3sl2r0k 29 32 beyond beyond IN cord-354035-i3sl2r0k 29 33 the the DT cord-354035-i3sl2r0k 29 34 common common JJ cord-354035-i3sl2r0k 29 35 , , , cord-354035-i3sl2r0k 29 36 known know VBN cord-354035-i3sl2r0k 29 37 respiratory respiratory JJ cord-354035-i3sl2r0k 29 38 pathogens pathogen NNS cord-354035-i3sl2r0k 29 39 are be VBP cord-354035-i3sl2r0k 29 40 detected detect VBN cord-354035-i3sl2r0k 29 41 . . . cord-354035-i3sl2r0k 30 1 In in IN cord-354035-i3sl2r0k 30 2 one one CD cord-354035-i3sl2r0k 30 3 study study NN cord-354035-i3sl2r0k 30 4 , , , cord-354035-i3sl2r0k 30 5 210 210 CD cord-354035-i3sl2r0k 30 6 adults adult NNS cord-354035-i3sl2r0k 30 7 and and CC cord-354035-i3sl2r0k 30 8 children child NNS cord-354035-i3sl2r0k 30 9 with with IN cord-354035-i3sl2r0k 30 10 severe severe JJ cord-354035-i3sl2r0k 30 11 lower low JJR cord-354035-i3sl2r0k 30 12 respiratory respiratory JJ cord-354035-i3sl2r0k 30 13 tract tract NN cord-354035-i3sl2r0k 30 14 infections infection NNS cord-354035-i3sl2r0k 30 15 were be VBD cord-354035-i3sl2r0k 30 16 sampled sample VBN cord-354035-i3sl2r0k 30 17 . . . cord-354035-i3sl2r0k 31 1 4 4 CD cord-354035-i3sl2r0k 31 2 Nasopharyngeal Nasopharyngeal NNP cord-354035-i3sl2r0k 31 3 aspirates aspirate NNS cord-354035-i3sl2r0k 31 4 were be VBD cord-354035-i3sl2r0k 31 5 collected collect VBN cord-354035-i3sl2r0k 31 6 and and CC cord-354035-i3sl2r0k 31 7 samples sample NNS cord-354035-i3sl2r0k 31 8 were be VBD cord-354035-i3sl2r0k 31 9 combined combine VBN cord-354035-i3sl2r0k 31 10 , , , cord-354035-i3sl2r0k 31 11 creating create VBG cord-354035-i3sl2r0k 31 12 13 13 CD cord-354035-i3sl2r0k 31 13 pools pool NNS cord-354035-i3sl2r0k 31 14 of of IN cord-354035-i3sl2r0k 31 15 8 8 CD cord-354035-i3sl2r0k 31 16 to to TO cord-354035-i3sl2r0k 31 17 24 24 CD cord-354035-i3sl2r0k 31 18 samples sample NNS cord-354035-i3sl2r0k 31 19 per per IN cord-354035-i3sl2r0k 31 20 pool pool NN cord-354035-i3sl2r0k 31 21 . . . cord-354035-i3sl2r0k 32 1 Virus virus NN cord-354035-i3sl2r0k 32 2 particles particle NNS cord-354035-i3sl2r0k 32 3 were be VBD cord-354035-i3sl2r0k 32 4 enriched enrich VBN cord-354035-i3sl2r0k 32 5 , , , cord-354035-i3sl2r0k 32 6 and and CC cord-354035-i3sl2r0k 32 7 DNA DNA NNP cord-354035-i3sl2r0k 32 8 and and CC cord-354035-i3sl2r0k 32 9 RNA RNA NNP cord-354035-i3sl2r0k 32 10 viruses virus NNS cord-354035-i3sl2r0k 32 11 were be VBD cord-354035-i3sl2r0k 32 12 assessed assess VBN cord-354035-i3sl2r0k 32 13 using use VBG cord-354035-i3sl2r0k 32 14 HTS HTS NNP cord-354035-i3sl2r0k 32 15 . . . cord-354035-i3sl2r0k 33 1 Thirty thirty CD cord-354035-i3sl2r0k 33 2 - - HYPH cord-354035-i3sl2r0k 33 3 nine nine CD cord-354035-i3sl2r0k 33 4 viral viral JJ cord-354035-i3sl2r0k 33 5 species specie NNS cord-354035-i3sl2r0k 33 6 were be VBD cord-354035-i3sl2r0k 33 7 observed observe VBN cord-354035-i3sl2r0k 33 8 in in IN cord-354035-i3sl2r0k 33 9 these these DT cord-354035-i3sl2r0k 33 10 samples sample NNS cord-354035-i3sl2r0k 33 11 , , , cord-354035-i3sl2r0k 33 12 giving give VBG cord-354035-i3sl2r0k 33 13 a a DT cord-354035-i3sl2r0k 33 14 broad broad JJ cord-354035-i3sl2r0k 33 15 view view NN cord-354035-i3sl2r0k 33 16 of of IN cord-354035-i3sl2r0k 33 17 the the DT cord-354035-i3sl2r0k 33 18 scope scope NN cord-354035-i3sl2r0k 33 19 of of IN cord-354035-i3sl2r0k 33 20 the the DT cord-354035-i3sl2r0k 33 21 respiratory respiratory JJ cord-354035-i3sl2r0k 33 22 tract tract NN cord-354035-i3sl2r0k 33 23 virome virome NN cord-354035-i3sl2r0k 33 24 during during IN cord-354035-i3sl2r0k 33 25 infection infection NN cord-354035-i3sl2r0k 33 26 . . . cord-354035-i3sl2r0k 34 1 Based base VBN cord-354035-i3sl2r0k 34 2 on on IN cord-354035-i3sl2r0k 34 3 read read NN cord-354035-i3sl2r0k 34 4 counts count NNS cord-354035-i3sl2r0k 34 5 , , , cord-354035-i3sl2r0k 34 6 the the DT cord-354035-i3sl2r0k 34 7 most most RBS cord-354035-i3sl2r0k 34 8 abundant abundant JJ cord-354035-i3sl2r0k 34 9 viruses virus NNS cord-354035-i3sl2r0k 34 10 in in IN cord-354035-i3sl2r0k 34 11 the the DT cord-354035-i3sl2r0k 34 12 data datum NNS cord-354035-i3sl2r0k 34 13 set set VBN cord-354035-i3sl2r0k 34 14 were be VBD cord-354035-i3sl2r0k 34 15 the the DT cord-354035-i3sl2r0k 34 16 paramyxoviruses paramyxovirus NNS cord-354035-i3sl2r0k 34 17 Methods method NNS cord-354035-i3sl2r0k 34 18 for for IN cord-354035-i3sl2r0k 34 19 characterizing characterize VBG cord-354035-i3sl2r0k 34 20 viruses virus NNS cord-354035-i3sl2r0k 34 21 in in IN cord-354035-i3sl2r0k 34 22 the the DT cord-354035-i3sl2r0k 34 23 respiratory respiratory JJ cord-354035-i3sl2r0k 34 24 tract tract NN cord-354035-i3sl2r0k 34 25 . . . cord-354035-i3sl2r0k 35 1 Current current JJ cord-354035-i3sl2r0k 35 2 molecular molecular JJ cord-354035-i3sl2r0k 35 3 methods method NNS cord-354035-i3sl2r0k 35 4 , , , cord-354035-i3sl2r0k 35 5 such such JJ cord-354035-i3sl2r0k 35 6 as as IN cord-354035-i3sl2r0k 35 7 PCR PCR NNP cord-354035-i3sl2r0k 35 8 and and CC cord-354035-i3sl2r0k 35 9 HTS HTS NNP cord-354035-i3sl2r0k 35 10 , , , cord-354035-i3sl2r0k 35 11 have have VBP cord-354035-i3sl2r0k 35 12 clear clear JJ cord-354035-i3sl2r0k 35 13 advantages advantage NNS cord-354035-i3sl2r0k 35 14 over over IN cord-354035-i3sl2r0k 35 15 older old JJR cord-354035-i3sl2r0k 35 16 methods method NNS cord-354035-i3sl2r0k 35 17 ( ( -LRB- cord-354035-i3sl2r0k 35 18 culture culture NN cord-354035-i3sl2r0k 35 19 and and CC cord-354035-i3sl2r0k 35 20 serology serology NN cord-354035-i3sl2r0k 35 21 ) ) -RRB- cord-354035-i3sl2r0k 35 22 in in IN cord-354035-i3sl2r0k 35 23 terms term NNS cord-354035-i3sl2r0k 35 24 of of IN cord-354035-i3sl2r0k 35 25 cost cost NN cord-354035-i3sl2r0k 35 26 , , , cord-354035-i3sl2r0k 35 27 speed speed NN cord-354035-i3sl2r0k 35 28 , , , cord-354035-i3sl2r0k 35 29 and and CC cord-354035-i3sl2r0k 35 30 sensitivity sensitivity NN cord-354035-i3sl2r0k 35 31 . . . cord-354035-i3sl2r0k 36 1 Future future JJ cord-354035-i3sl2r0k 36 2 assays assay NNS cord-354035-i3sl2r0k 36 3 for for IN cord-354035-i3sl2r0k 36 4 research research NN cord-354035-i3sl2r0k 36 5 and and CC cord-354035-i3sl2r0k 36 6 diagnostics diagnostic NNS cord-354035-i3sl2r0k 36 7 will will MD cord-354035-i3sl2r0k 36 8 be be VB cord-354035-i3sl2r0k 36 9 aimed aim VBN cord-354035-i3sl2r0k 36 10 at at IN cord-354035-i3sl2r0k 36 11 capturing capture VBG cord-354035-i3sl2r0k 36 12 and and CC cord-354035-i3sl2r0k 36 13 improving improve VBG cord-354035-i3sl2r0k 36 14 on on IN cord-354035-i3sl2r0k 36 15 the the DT cord-354035-i3sl2r0k 36 16 best good JJS cord-354035-i3sl2r0k 36 17 features feature NNS cord-354035-i3sl2r0k 36 18 of of IN cord-354035-i3sl2r0k 36 19 the the DT cord-354035-i3sl2r0k 36 20 current current JJ cord-354035-i3sl2r0k 36 21 methods method NNS cord-354035-i3sl2r0k 36 22 . . . cord-354035-i3sl2r0k 37 1 The the DT cord-354035-i3sl2r0k 37 2 Virome Virome NNP cord-354035-i3sl2r0k 37 3 of of IN cord-354035-i3sl2r0k 37 4 the the DT cord-354035-i3sl2r0k 37 5 Human Human NNP cord-354035-i3sl2r0k 37 6 Respiratory Respiratory NNP cord-354035-i3sl2r0k 37 7 Tract Tract NNP cord-354035-i3sl2r0k 37 8 ( ( -LRB- cord-354035-i3sl2r0k 37 9 including include VBG cord-354035-i3sl2r0k 37 10 human human JJ cord-354035-i3sl2r0k 37 11 respiratory respiratory JJ cord-354035-i3sl2r0k 37 12 syncytial syncytial JJ cord-354035-i3sl2r0k 37 13 virus virus NN cord-354035-i3sl2r0k 37 14 , , , cord-354035-i3sl2r0k 37 15 human human JJ cord-354035-i3sl2r0k 37 16 metapneumovirus metapneumovirus NNP cord-354035-i3sl2r0k 37 17 ) ) -RRB- cord-354035-i3sl2r0k 37 18 . . . cord-354035-i3sl2r0k 38 1 Picornaviruses Picornaviruses NNP cord-354035-i3sl2r0k 38 2 were be VBD cord-354035-i3sl2r0k 38 3 the the DT cord-354035-i3sl2r0k 38 4 next next JJ cord-354035-i3sl2r0k 38 5 most most RBS cord-354035-i3sl2r0k 38 6 abundant abundant JJ cord-354035-i3sl2r0k 38 7 ( ( -LRB- cord-354035-i3sl2r0k 38 8 primarily primarily RB cord-354035-i3sl2r0k 38 9 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 38 10 A A NNP cord-354035-i3sl2r0k 38 11 and and CC cord-354035-i3sl2r0k 38 12 C C NNP cord-354035-i3sl2r0k 38 13 ) ) -RRB- cord-354035-i3sl2r0k 38 14 . . . cord-354035-i3sl2r0k 39 1 Orthomyxoviruses orthomyxovirus NNS cord-354035-i3sl2r0k 39 2 were be VBD cord-354035-i3sl2r0k 39 3 the the DT cord-354035-i3sl2r0k 39 4 third third JJ cord-354035-i3sl2r0k 39 5 most most RBS cord-354035-i3sl2r0k 39 6 abundant abundant JJ cord-354035-i3sl2r0k 40 1 ( ( -LRB- cord-354035-i3sl2r0k 40 2 influenza influenza NN cord-354035-i3sl2r0k 40 3 viruses viruse VBZ cord-354035-i3sl2r0k 40 4 A A NNP cord-354035-i3sl2r0k 40 5 , , , cord-354035-i3sl2r0k 40 6 B b NN cord-354035-i3sl2r0k 40 7 , , , cord-354035-i3sl2r0k 40 8 and and CC cord-354035-i3sl2r0k 40 9 C C NNP cord-354035-i3sl2r0k 40 10 ) ) -RRB- cord-354035-i3sl2r0k 40 11 . . . cord-354035-i3sl2r0k 41 1 There there EX cord-354035-i3sl2r0k 41 2 were be VBD cord-354035-i3sl2r0k 41 3 several several JJ cord-354035-i3sl2r0k 41 4 rare rare JJ cord-354035-i3sl2r0k 41 5 and/or and/or CC cord-354035-i3sl2r0k 41 6 unexpected unexpected JJ cord-354035-i3sl2r0k 41 7 viruses virus NNS cord-354035-i3sl2r0k 41 8 represented represent VBN cord-354035-i3sl2r0k 41 9 at at IN cord-354035-i3sl2r0k 41 10 low low JJ cord-354035-i3sl2r0k 41 11 abundance abundance NN cord-354035-i3sl2r0k 41 12 . . . cord-354035-i3sl2r0k 42 1 These these DT cord-354035-i3sl2r0k 42 2 viruses virus NNS cord-354035-i3sl2r0k 42 3 included include VBD cord-354035-i3sl2r0k 42 4 bocavirus bocavirus NNP cord-354035-i3sl2r0k 42 5 , , , cord-354035-i3sl2r0k 42 6 KI KI NNP cord-354035-i3sl2r0k 42 7 polyomavirus polyomavirus NNP cord-354035-i3sl2r0k 42 8 , , , cord-354035-i3sl2r0k 42 9 picobirnavirus picobirnavirus NNP cord-354035-i3sl2r0k 42 10 , , , cord-354035-i3sl2r0k 42 11 measles measles NN cord-354035-i3sl2r0k 42 12 virus virus NN cord-354035-i3sl2r0k 42 13 , , , cord-354035-i3sl2r0k 42 14 and and CC cord-354035-i3sl2r0k 42 15 anelloviruses anelloviruse NNS cord-354035-i3sl2r0k 42 16 . . . cord-354035-i3sl2r0k 43 1 In in IN cord-354035-i3sl2r0k 43 2 a a DT cord-354035-i3sl2r0k 43 3 study study NN cord-354035-i3sl2r0k 43 4 from from IN cord-354035-i3sl2r0k 43 5 China China NNP cord-354035-i3sl2r0k 43 6 , , , cord-354035-i3sl2r0k 43 7 a a DT cord-354035-i3sl2r0k 43 8 similar similar JJ cord-354035-i3sl2r0k 43 9 sequencing sequencing NN cord-354035-i3sl2r0k 43 10 - - HYPH cord-354035-i3sl2r0k 43 11 based base VBN cord-354035-i3sl2r0k 43 12 approach approach NN cord-354035-i3sl2r0k 43 13 was be VBD cord-354035-i3sl2r0k 43 14 taken take VBN cord-354035-i3sl2r0k 43 15 to to TO cord-354035-i3sl2r0k 43 16 characterize characterize VB cord-354035-i3sl2r0k 43 17 the the DT cord-354035-i3sl2r0k 43 18 virome virome NN cord-354035-i3sl2r0k 43 19 in in IN cord-354035-i3sl2r0k 43 20 children child NNS cord-354035-i3sl2r0k 43 21 less less JJR cord-354035-i3sl2r0k 43 22 than than IN cord-354035-i3sl2r0k 43 23 6 6 CD cord-354035-i3sl2r0k 43 24 years year NNS cord-354035-i3sl2r0k 43 25 old old JJ cord-354035-i3sl2r0k 43 26 with with IN cord-354035-i3sl2r0k 43 27 severe severe JJ cord-354035-i3sl2r0k 43 28 acute acute JJ cord-354035-i3sl2r0k 43 29 respiratory respiratory JJ cord-354035-i3sl2r0k 43 30 illness illness NN cord-354035-i3sl2r0k 43 31 and and CC cord-354035-i3sl2r0k 43 32 15 15 CD cord-354035-i3sl2r0k 43 33 controls control NNS cord-354035-i3sl2r0k 43 34 without without IN cord-354035-i3sl2r0k 43 35 respiratory respiratory JJ cord-354035-i3sl2r0k 43 36 illness illness NN cord-354035-i3sl2r0k 43 37 . . . cord-354035-i3sl2r0k 44 1 5 5 CD cord-354035-i3sl2r0k 44 2 Nasopharyngeal Nasopharyngeal NNP cord-354035-i3sl2r0k 44 3 swabs swab NNS cord-354035-i3sl2r0k 44 4 were be VBD cord-354035-i3sl2r0k 44 5 pooled pool VBN cord-354035-i3sl2r0k 44 6 into into IN cord-354035-i3sl2r0k 44 7 9 9 CD cord-354035-i3sl2r0k 44 8 pools pool NNS cord-354035-i3sl2r0k 44 9 of of IN cord-354035-i3sl2r0k 44 10 15 15 CD cord-354035-i3sl2r0k 44 11 samples sample NNS cord-354035-i3sl2r0k 44 12 each each DT cord-354035-i3sl2r0k 44 13 ; ; : cord-354035-i3sl2r0k 44 14 virus virus NN cord-354035-i3sl2r0k 44 15 particles particle NNS cord-354035-i3sl2r0k 44 16 were be VBD cord-354035-i3sl2r0k 44 17 enriched enrich VBN cord-354035-i3sl2r0k 44 18 ; ; : cord-354035-i3sl2r0k 44 19 and and CC cord-354035-i3sl2r0k 44 20 HTS HTS NNP cord-354035-i3sl2r0k 44 21 data datum NNS cord-354035-i3sl2r0k 44 22 were be VBD cord-354035-i3sl2r0k 44 23 generated generate VBN cord-354035-i3sl2r0k 44 24 to to TO cord-354035-i3sl2r0k 44 25 assess assess VB cord-354035-i3sl2r0k 44 26 both both DT cord-354035-i3sl2r0k 44 27 RNA RNA NNP cord-354035-i3sl2r0k 44 28 and and CC cord-354035-i3sl2r0k 44 29 DNA dna NN cord-354035-i3sl2r0k 44 30 viruses virus NNS cord-354035-i3sl2r0k 44 31 . . . cord-354035-i3sl2r0k 45 1 The the DT cord-354035-i3sl2r0k 45 2 most most RBS cord-354035-i3sl2r0k 45 3 highly highly RB cord-354035-i3sl2r0k 45 4 represented represent VBN cord-354035-i3sl2r0k 45 5 viruses virus NNS cord-354035-i3sl2r0k 45 6 included include VBD cord-354035-i3sl2r0k 45 7 the the DT cord-354035-i3sl2r0k 45 8 paramyxoviruses paramyxovirus NNS cord-354035-i3sl2r0k 45 9 ( ( -LRB- cord-354035-i3sl2r0k 45 10 primarily primarily RB cord-354035-i3sl2r0k 45 11 human human JJ cord-354035-i3sl2r0k 45 12 respiratory respiratory JJ cord-354035-i3sl2r0k 45 13 syncytial syncytial JJ cord-354035-i3sl2r0k 45 14 virus virus NN cord-354035-i3sl2r0k 45 15 ) ) -RRB- cord-354035-i3sl2r0k 45 16 , , , cord-354035-i3sl2r0k 45 17 and and CC cord-354035-i3sl2r0k 45 18 the the DT cord-354035-i3sl2r0k 45 19 other other JJ cord-354035-i3sl2r0k 45 20 common common JJ cord-354035-i3sl2r0k 45 21 viruses virus NNS cord-354035-i3sl2r0k 45 22 detected detect VBN cord-354035-i3sl2r0k 45 23 in in IN cord-354035-i3sl2r0k 45 24 the the DT cord-354035-i3sl2r0k 45 25 study study NN cord-354035-i3sl2r0k 45 26 described describe VBN cord-354035-i3sl2r0k 45 27 earlier early RBR cord-354035-i3sl2r0k 45 28 were be VBD cord-354035-i3sl2r0k 45 29 detected detect VBN cord-354035-i3sl2r0k 45 30 . . . cord-354035-i3sl2r0k 46 1 This this DT cord-354035-i3sl2r0k 46 2 study study NN cord-354035-i3sl2r0k 46 3 also also RB cord-354035-i3sl2r0k 46 4 detected detect VBD cord-354035-i3sl2r0k 46 5 human human JJ cord-354035-i3sl2r0k 46 6 coronaviruses coronaviruse NNS cord-354035-i3sl2r0k 46 7 , , , cord-354035-i3sl2r0k 46 8 bocaviruses bocaviruses NNP cord-354035-i3sl2r0k 46 9 , , , cord-354035-i3sl2r0k 46 10 picornaviruses picornaviruses NNP cord-354035-i3sl2r0k 46 11 , , , cord-354035-i3sl2r0k 46 12 influenza influenza NN cord-354035-i3sl2r0k 46 13 viruses virus NNS cord-354035-i3sl2r0k 46 14 , , , cord-354035-i3sl2r0k 46 15 adenoviruses adenovirus NNS cord-354035-i3sl2r0k 46 16 , , , cord-354035-i3sl2r0k 46 17 and and CC cord-354035-i3sl2r0k 46 18 anelloviruses anelloviruse NNS cord-354035-i3sl2r0k 46 19 . . . cord-354035-i3sl2r0k 47 1 Rare rare JJ cord-354035-i3sl2r0k 47 2 sequences sequence NNS cord-354035-i3sl2r0k 47 3 included include VBD cord-354035-i3sl2r0k 47 4 those those DT cord-354035-i3sl2r0k 47 5 from from IN cord-354035-i3sl2r0k 47 6 metapneumovirus metapneumovirus NNP cord-354035-i3sl2r0k 47 7 , , , cord-354035-i3sl2r0k 47 8 measles measle NNS cord-354035-i3sl2r0k 47 9 , , , cord-354035-i3sl2r0k 47 10 hepatitis hepatitis NNP cord-354035-i3sl2r0k 47 11 B B NNP cord-354035-i3sl2r0k 47 12 and and CC cord-354035-i3sl2r0k 47 13 C C NNP cord-354035-i3sl2r0k 47 14 , , , cord-354035-i3sl2r0k 47 15 papillomavirus papillomavirus NN cord-354035-i3sl2r0k 47 16 , , , cord-354035-i3sl2r0k 47 17 and and CC cord-354035-i3sl2r0k 47 18 others other NNS cord-354035-i3sl2r0k 47 19 . . . cord-354035-i3sl2r0k 48 1 These these DT cord-354035-i3sl2r0k 48 2 two two CD cord-354035-i3sl2r0k 48 3 studies study NNS cord-354035-i3sl2r0k 48 4 demonstrate demonstrate VBP cord-354035-i3sl2r0k 48 5 the the DT cord-354035-i3sl2r0k 48 6 power power NN cord-354035-i3sl2r0k 48 7 of of IN cord-354035-i3sl2r0k 48 8 HTS HTS NNP cord-354035-i3sl2r0k 48 9 compared compare VBN cord-354035-i3sl2r0k 48 10 with with IN cord-354035-i3sl2r0k 48 11 targeted target VBN cord-354035-i3sl2r0k 48 12 PCR PCR NNP cord-354035-i3sl2r0k 48 13 assays assay NNS cord-354035-i3sl2r0k 48 14 for for IN cord-354035-i3sl2r0k 48 15 defining define VBG cord-354035-i3sl2r0k 48 16 the the DT cord-354035-i3sl2r0k 48 17 virome virome NN cord-354035-i3sl2r0k 48 18 . . . cord-354035-i3sl2r0k 49 1 In in IN cord-354035-i3sl2r0k 49 2 both both DT cord-354035-i3sl2r0k 49 3 studies study NNS cord-354035-i3sl2r0k 49 4 , , , cord-354035-i3sl2r0k 49 5 common common JJ cord-354035-i3sl2r0k 49 6 and and CC cord-354035-i3sl2r0k 49 7 expected expect VBN cord-354035-i3sl2r0k 49 8 respiratory respiratory JJ cord-354035-i3sl2r0k 49 9 pathogens pathogen NNS cord-354035-i3sl2r0k 49 10 were be VBD cord-354035-i3sl2r0k 49 11 detected detect VBN cord-354035-i3sl2r0k 49 12 . . . cord-354035-i3sl2r0k 50 1 However however RB cord-354035-i3sl2r0k 50 2 , , , cord-354035-i3sl2r0k 50 3 other other JJ cord-354035-i3sl2r0k 50 4 viruses virus NNS cord-354035-i3sl2r0k 50 5 , , , cord-354035-i3sl2r0k 50 6 some some DT cord-354035-i3sl2r0k 50 7 with with IN cord-354035-i3sl2r0k 50 8 unknown unknown JJ cord-354035-i3sl2r0k 50 9 pathogenicity pathogenicity NN cord-354035-i3sl2r0k 50 10 in in IN cord-354035-i3sl2r0k 50 11 the the DT cord-354035-i3sl2r0k 50 12 respiratory respiratory JJ cord-354035-i3sl2r0k 50 13 tract tract NN cord-354035-i3sl2r0k 50 14 , , , cord-354035-i3sl2r0k 50 15 were be VBD cord-354035-i3sl2r0k 50 16 also also RB cord-354035-i3sl2r0k 50 17 detected detect VBN cord-354035-i3sl2r0k 50 18 . . . cord-354035-i3sl2r0k 51 1 Detection detection NN cord-354035-i3sl2r0k 51 2 of of IN cord-354035-i3sl2r0k 51 3 these these DT cord-354035-i3sl2r0k 51 4 viruses virus NNS cord-354035-i3sl2r0k 51 5 is be VBZ cord-354035-i3sl2r0k 51 6 valuable valuable JJ cord-354035-i3sl2r0k 51 7 as as IN cord-354035-i3sl2r0k 51 8 we -PRON- PRP cord-354035-i3sl2r0k 51 9 aim aim VBP cord-354035-i3sl2r0k 51 10 to to TO cord-354035-i3sl2r0k 51 11 fully fully RB cord-354035-i3sl2r0k 51 12 understand understand VB cord-354035-i3sl2r0k 51 13 the the DT cord-354035-i3sl2r0k 51 14 biology biology NN cord-354035-i3sl2r0k 51 15 of of IN cord-354035-i3sl2r0k 51 16 the the DT cord-354035-i3sl2r0k 51 17 respiratory respiratory JJ cord-354035-i3sl2r0k 51 18 tract tract NN cord-354035-i3sl2r0k 51 19 . . . cord-354035-i3sl2r0k 52 1 Although although IN cord-354035-i3sl2r0k 52 2 these these DT cord-354035-i3sl2r0k 52 3 studies study NNS cord-354035-i3sl2r0k 52 4 were be VBD cord-354035-i3sl2r0k 52 5 exploratory exploratory JJ cord-354035-i3sl2r0k 52 6 , , , cord-354035-i3sl2r0k 52 7 they -PRON- PRP cord-354035-i3sl2r0k 52 8 raise raise VBP cord-354035-i3sl2r0k 52 9 questions question NNS cord-354035-i3sl2r0k 52 10 about about IN cord-354035-i3sl2r0k 52 11 whether whether IN cord-354035-i3sl2r0k 52 12 some some DT cord-354035-i3sl2r0k 52 13 of of IN cord-354035-i3sl2r0k 52 14 the the DT cord-354035-i3sl2r0k 52 15 viruses virus NNS cord-354035-i3sl2r0k 52 16 with with IN cord-354035-i3sl2r0k 52 17 unclear unclear JJ cord-354035-i3sl2r0k 52 18 pathogenicity pathogenicity NN cord-354035-i3sl2r0k 52 19 could could MD cord-354035-i3sl2r0k 52 20 be be VB cord-354035-i3sl2r0k 52 21 contributing contribute VBG cord-354035-i3sl2r0k 52 22 to to IN cord-354035-i3sl2r0k 52 23 the the DT cord-354035-i3sl2r0k 52 24 presentation presentation NN cord-354035-i3sl2r0k 52 25 of of IN cord-354035-i3sl2r0k 52 26 symptoms symptom NNS cord-354035-i3sl2r0k 52 27 , , , cord-354035-i3sl2r0k 52 28 complicating complicate VBG cord-354035-i3sl2r0k 52 29 the the DT cord-354035-i3sl2r0k 52 30 course course NN cord-354035-i3sl2r0k 52 31 of of IN cord-354035-i3sl2r0k 52 32 infection infection NN cord-354035-i3sl2r0k 52 33 with with IN cord-354035-i3sl2r0k 52 34 other other JJ cord-354035-i3sl2r0k 52 35 pathogens pathogen NNS cord-354035-i3sl2r0k 52 36 , , , cord-354035-i3sl2r0k 52 37 or or CC cord-354035-i3sl2r0k 52 38 are be VBP cord-354035-i3sl2r0k 52 39 biomarkers biomarker NNS cord-354035-i3sl2r0k 52 40 for for IN cord-354035-i3sl2r0k 52 41 infection infection NN cord-354035-i3sl2r0k 52 42 or or CC cord-354035-i3sl2r0k 52 43 host host NN cord-354035-i3sl2r0k 52 44 response response NN cord-354035-i3sl2r0k 52 45 . . . cord-354035-i3sl2r0k 53 1 These these DT cord-354035-i3sl2r0k 53 2 questions question NNS cord-354035-i3sl2r0k 53 3 remain remain VBP cord-354035-i3sl2r0k 53 4 to to TO cord-354035-i3sl2r0k 53 5 be be VB cord-354035-i3sl2r0k 53 6 addressed address VBN cord-354035-i3sl2r0k 53 7 in in IN cord-354035-i3sl2r0k 53 8 future future JJ cord-354035-i3sl2r0k 53 9 studies study NNS cord-354035-i3sl2r0k 53 10 . . . cord-354035-i3sl2r0k 54 1 Viruses virus NNS cord-354035-i3sl2r0k 54 2 are be VBP cord-354035-i3sl2r0k 54 3 clearly clearly RB cord-354035-i3sl2r0k 54 4 an an DT cord-354035-i3sl2r0k 54 5 important important JJ cord-354035-i3sl2r0k 54 6 cause cause NN cord-354035-i3sl2r0k 54 7 of of IN cord-354035-i3sl2r0k 54 8 pneumonia pneumonia NN cord-354035-i3sl2r0k 54 9 , , , cord-354035-i3sl2r0k 54 10 particularly particularly RB cord-354035-i3sl2r0k 54 11 in in IN cord-354035-i3sl2r0k 54 12 the the DT cord-354035-i3sl2r0k 54 13 postpneumococcal postpneumococcal JJ cord-354035-i3sl2r0k 54 14 vaccine vaccine NN cord-354035-i3sl2r0k 54 15 era era NN cord-354035-i3sl2r0k 54 16 . . . cord-354035-i3sl2r0k 55 1 A a DT cord-354035-i3sl2r0k 55 2 prospective prospective JJ cord-354035-i3sl2r0k 55 3 multicenter multicenter JJ cord-354035-i3sl2r0k 55 4 study study NN cord-354035-i3sl2r0k 55 5 sponsored sponsor VBN cord-354035-i3sl2r0k 55 6 by by IN cord-354035-i3sl2r0k 55 7 the the DT cord-354035-i3sl2r0k 55 8 Centers Centers NNPS cord-354035-i3sl2r0k 55 9 for for IN cord-354035-i3sl2r0k 55 10 Disease Disease NNP cord-354035-i3sl2r0k 55 11 Control Control NNP cord-354035-i3sl2r0k 55 12 and and CC cord-354035-i3sl2r0k 55 13 Prevention Prevention NNP cord-354035-i3sl2r0k 55 14 focused focus VBD cord-354035-i3sl2r0k 55 15 on on IN cord-354035-i3sl2r0k 55 16 the the DT cord-354035-i3sl2r0k 55 17 Etiology Etiology NNP cord-354035-i3sl2r0k 55 18 of of IN cord-354035-i3sl2r0k 55 19 Pneumonia Pneumonia NNP cord-354035-i3sl2r0k 55 20 in in IN cord-354035-i3sl2r0k 55 21 the the DT cord-354035-i3sl2r0k 55 22 Community Community NNP cord-354035-i3sl2r0k 55 23 ( ( -LRB- cord-354035-i3sl2r0k 55 24 EPIC EPIC NNP cord-354035-i3sl2r0k 55 25 ) ) -RRB- cord-354035-i3sl2r0k 55 26 . . . cord-354035-i3sl2r0k 56 1 6 6 CD cord-354035-i3sl2r0k 56 2 , , , cord-354035-i3sl2r0k 56 3 7 7 CD cord-354035-i3sl2r0k 57 1 This this DT cord-354035-i3sl2r0k 57 2 study study NN cord-354035-i3sl2r0k 57 3 used use VBD cord-354035-i3sl2r0k 57 4 extensive extensive JJ cord-354035-i3sl2r0k 57 5 diagnostic diagnostic JJ cord-354035-i3sl2r0k 57 6 testing testing NN cord-354035-i3sl2r0k 57 7 ( ( -LRB- cord-354035-i3sl2r0k 57 8 culture culture NN cord-354035-i3sl2r0k 57 9 , , , cord-354035-i3sl2r0k 57 10 serology serology NN cord-354035-i3sl2r0k 57 11 , , , cord-354035-i3sl2r0k 57 12 molecular molecular JJ cord-354035-i3sl2r0k 57 13 testing testing NN cord-354035-i3sl2r0k 57 14 ) ) -RRB- cord-354035-i3sl2r0k 57 15 to to TO cord-354035-i3sl2r0k 57 16 understand understand VB cord-354035-i3sl2r0k 57 17 the the DT cord-354035-i3sl2r0k 57 18 causes cause NNS cord-354035-i3sl2r0k 57 19 of of IN cord-354035-i3sl2r0k 57 20 pneumonia pneumonia NN cord-354035-i3sl2r0k 57 21 in in IN cord-354035-i3sl2r0k 57 22 more more JJR cord-354035-i3sl2r0k 57 23 than than IN cord-354035-i3sl2r0k 57 24 2000 2000 CD cord-354035-i3sl2r0k 57 25 adults adult NNS cord-354035-i3sl2r0k 57 26 in in IN cord-354035-i3sl2r0k 57 27 the the DT cord-354035-i3sl2r0k 57 28 United United NNP cord-354035-i3sl2r0k 57 29 States States NNP cord-354035-i3sl2r0k 57 30 , , , cord-354035-i3sl2r0k 57 31 in in IN cord-354035-i3sl2r0k 57 32 the the DT cord-354035-i3sl2r0k 57 33 time time NN cord-354035-i3sl2r0k 57 34 after after IN cord-354035-i3sl2r0k 57 35 the the DT cord-354035-i3sl2r0k 57 36 implementation implementation NN cord-354035-i3sl2r0k 57 37 of of IN cord-354035-i3sl2r0k 57 38 the the DT cord-354035-i3sl2r0k 57 39 pneumococcal pneumococcal JJ cord-354035-i3sl2r0k 57 40 vaccine vaccine NN cord-354035-i3sl2r0k 57 41 . . . cord-354035-i3sl2r0k 58 1 In in IN cord-354035-i3sl2r0k 58 2 this this DT cord-354035-i3sl2r0k 58 3 study study NN cord-354035-i3sl2r0k 58 4 , , , cord-354035-i3sl2r0k 58 5 a a DT cord-354035-i3sl2r0k 58 6 pathogen pathogen NN cord-354035-i3sl2r0k 58 7 was be VBD cord-354035-i3sl2r0k 58 8 detected detect VBN cord-354035-i3sl2r0k 58 9 in in IN cord-354035-i3sl2r0k 58 10 38 38 CD cord-354035-i3sl2r0k 58 11 % % NN cord-354035-i3sl2r0k 58 12 of of IN cord-354035-i3sl2r0k 58 13 the the DT cord-354035-i3sl2r0k 58 14 samples sample NNS cord-354035-i3sl2r0k 58 15 . . . cord-354035-i3sl2r0k 59 1 At at RB cord-354035-i3sl2r0k 59 2 least least JJS cord-354035-i3sl2r0k 59 3 1 1 CD cord-354035-i3sl2r0k 59 4 virus virus NN cord-354035-i3sl2r0k 59 5 was be VBD cord-354035-i3sl2r0k 59 6 detected detect VBN cord-354035-i3sl2r0k 59 7 in in IN cord-354035-i3sl2r0k 59 8 23 23 CD cord-354035-i3sl2r0k 59 9 % % NN cord-354035-i3sl2r0k 59 10 of of IN cord-354035-i3sl2r0k 59 11 the the DT cord-354035-i3sl2r0k 59 12 samples sample NNS cord-354035-i3sl2r0k 59 13 available available JJ cord-354035-i3sl2r0k 59 14 for for IN cord-354035-i3sl2r0k 59 15 testing testing NN cord-354035-i3sl2r0k 59 16 , , , cord-354035-i3sl2r0k 59 17 and and CC cord-354035-i3sl2r0k 59 18 3 3 CD cord-354035-i3sl2r0k 59 19 % % NN cord-354035-i3sl2r0k 59 20 had have VBD cord-354035-i3sl2r0k 59 21 both both DT cord-354035-i3sl2r0k 59 22 bacterial bacterial JJ cord-354035-i3sl2r0k 59 23 and and CC cord-354035-i3sl2r0k 59 24 viral viral JJ cord-354035-i3sl2r0k 59 25 pathogens pathogen NNS cord-354035-i3sl2r0k 59 26 detected detect VBD cord-354035-i3sl2r0k 59 27 . . . cord-354035-i3sl2r0k 60 1 Rhinoviruses Rhinoviruses NNP cord-354035-i3sl2r0k 60 2 and and CC cord-354035-i3sl2r0k 60 3 influenza influenza NN cord-354035-i3sl2r0k 60 4 viruses virus NNS cord-354035-i3sl2r0k 60 5 were be VBD cord-354035-i3sl2r0k 60 6 the the DT cord-354035-i3sl2r0k 60 7 most most RBS cord-354035-i3sl2r0k 60 8 common common JJ cord-354035-i3sl2r0k 60 9 pathogens pathogen NNS cord-354035-i3sl2r0k 60 10 detected detect VBN cord-354035-i3sl2r0k 60 11 in in IN cord-354035-i3sl2r0k 60 12 9 9 CD cord-354035-i3sl2r0k 60 13 % % NN cord-354035-i3sl2r0k 60 14 and and CC cord-354035-i3sl2r0k 60 15 6 6 CD cord-354035-i3sl2r0k 60 16 % % NN cord-354035-i3sl2r0k 60 17 of of IN cord-354035-i3sl2r0k 60 18 patients patient NNS cord-354035-i3sl2r0k 60 19 , , , cord-354035-i3sl2r0k 60 20 respectively respectively RB cord-354035-i3sl2r0k 60 21 . . . cord-354035-i3sl2r0k 61 1 The the DT cord-354035-i3sl2r0k 61 2 EPIC EPIC NNP cord-354035-i3sl2r0k 61 3 study study NN cord-354035-i3sl2r0k 61 4 took take VBD cord-354035-i3sl2r0k 61 5 a a DT cord-354035-i3sl2r0k 61 6 similar similar JJ cord-354035-i3sl2r0k 61 7 approach approach NN cord-354035-i3sl2r0k 61 8 to to TO cord-354035-i3sl2r0k 61 9 study study VB cord-354035-i3sl2r0k 61 10 the the DT cord-354035-i3sl2r0k 61 11 cause cause NN cord-354035-i3sl2r0k 61 12 of of IN cord-354035-i3sl2r0k 61 13 community community NN cord-354035-i3sl2r0k 61 14 - - HYPH cord-354035-i3sl2r0k 61 15 acquired acquire VBN cord-354035-i3sl2r0k 61 16 pneumonia pneumonia NN cord-354035-i3sl2r0k 61 17 in in IN cord-354035-i3sl2r0k 61 18 children child NNS cord-354035-i3sl2r0k 61 19 . . . cord-354035-i3sl2r0k 62 1 Again again RB cord-354035-i3sl2r0k 62 2 , , , cord-354035-i3sl2r0k 62 3 more more JJR cord-354035-i3sl2r0k 62 4 than than IN cord-354035-i3sl2r0k 62 5 2000 2000 CD cord-354035-i3sl2r0k 62 6 subjects subject NNS cord-354035-i3sl2r0k 62 7 were be VBD cord-354035-i3sl2r0k 62 8 enrolled enrol VBN cord-354035-i3sl2r0k 62 9 . . . cord-354035-i3sl2r0k 63 1 The the DT cord-354035-i3sl2r0k 63 2 children child NNS cord-354035-i3sl2r0k 63 3 were be VBD cord-354035-i3sl2r0k 63 4 less less JJR cord-354035-i3sl2r0k 63 5 than than IN cord-354035-i3sl2r0k 63 6 18 18 CD cord-354035-i3sl2r0k 63 7 years year NNS cord-354035-i3sl2r0k 63 8 old old JJ cord-354035-i3sl2r0k 63 9 , , , cord-354035-i3sl2r0k 63 10 with with IN cord-354035-i3sl2r0k 63 11 a a DT cord-354035-i3sl2r0k 63 12 median median JJ cord-354035-i3sl2r0k 63 13 age age NN cord-354035-i3sl2r0k 63 14 of of IN cord-354035-i3sl2r0k 63 15 2 2 CD cord-354035-i3sl2r0k 63 16 years year NNS cord-354035-i3sl2r0k 63 17 . . . cord-354035-i3sl2r0k 64 1 A a DT cord-354035-i3sl2r0k 64 2 microbial microbial JJ cord-354035-i3sl2r0k 64 3 pathogen pathogen NN cord-354035-i3sl2r0k 64 4 was be VBD cord-354035-i3sl2r0k 64 5 detected detect VBN cord-354035-i3sl2r0k 64 6 in in IN cord-354035-i3sl2r0k 64 7 81 81 CD cord-354035-i3sl2r0k 64 8 % % NN cord-354035-i3sl2r0k 64 9 of of IN cord-354035-i3sl2r0k 64 10 samples sample NNS cord-354035-i3sl2r0k 64 11 . . . cord-354035-i3sl2r0k 65 1 At at RB cord-354035-i3sl2r0k 65 2 least least RBS cord-354035-i3sl2r0k 65 3 one one CD cord-354035-i3sl2r0k 65 4 virus virus NN cord-354035-i3sl2r0k 65 5 was be VBD cord-354035-i3sl2r0k 65 6 detected detect VBN cord-354035-i3sl2r0k 65 7 in in IN cord-354035-i3sl2r0k 65 8 66 66 CD cord-354035-i3sl2r0k 65 9 % % NN cord-354035-i3sl2r0k 65 10 of of IN cord-354035-i3sl2r0k 65 11 the the DT cord-354035-i3sl2r0k 65 12 samples sample NNS cord-354035-i3sl2r0k 65 13 , , , cord-354035-i3sl2r0k 65 14 and and CC cord-354035-i3sl2r0k 65 15 both both DT cord-354035-i3sl2r0k 65 16 bacterial bacterial JJ cord-354035-i3sl2r0k 65 17 and and CC cord-354035-i3sl2r0k 65 18 viral viral JJ cord-354035-i3sl2r0k 65 19 pathogens pathogen NNS cord-354035-i3sl2r0k 65 20 were be VBD cord-354035-i3sl2r0k 65 21 detected detect VBN cord-354035-i3sl2r0k 65 22 in in IN cord-354035-i3sl2r0k 65 23 7 7 CD cord-354035-i3sl2r0k 65 24 % % NN cord-354035-i3sl2r0k 65 25 of of IN cord-354035-i3sl2r0k 65 26 the the DT cord-354035-i3sl2r0k 65 27 children child NNS cord-354035-i3sl2r0k 65 28 . . . cord-354035-i3sl2r0k 66 1 In in IN cord-354035-i3sl2r0k 66 2 children child NNS cord-354035-i3sl2r0k 66 3 , , , cord-354035-i3sl2r0k 66 4 respiratory respiratory JJ cord-354035-i3sl2r0k 66 5 syncytial syncytial JJ cord-354035-i3sl2r0k 66 6 virus virus NN cord-354035-i3sl2r0k 66 7 , , , cord-354035-i3sl2r0k 66 8 rhinovirus rhinovirus NN cord-354035-i3sl2r0k 66 9 , , , cord-354035-i3sl2r0k 66 10 metapneumovirus metapneumovirus NNP cord-354035-i3sl2r0k 66 11 , , , cord-354035-i3sl2r0k 66 12 and and CC cord-354035-i3sl2r0k 66 13 adenovirus adenovirus NN cord-354035-i3sl2r0k 66 14 were be VBD cord-354035-i3sl2r0k 66 15 the the DT cord-354035-i3sl2r0k 66 16 most most RBS cord-354035-i3sl2r0k 66 17 common common JJ cord-354035-i3sl2r0k 66 18 pathogens pathogen NNS cord-354035-i3sl2r0k 66 19 . . . cord-354035-i3sl2r0k 67 1 These these DT cord-354035-i3sl2r0k 67 2 studies study NNS cord-354035-i3sl2r0k 67 3 identify identify VBP cord-354035-i3sl2r0k 67 4 viruses virus NNS cord-354035-i3sl2r0k 67 5 as as IN cord-354035-i3sl2r0k 67 6 key key JJ cord-354035-i3sl2r0k 67 7 pathogens pathogen NNS cord-354035-i3sl2r0k 67 8 in in IN cord-354035-i3sl2r0k 67 9 pneumonia pneumonia NN cord-354035-i3sl2r0k 67 10 since since IN cord-354035-i3sl2r0k 67 11 the the DT cord-354035-i3sl2r0k 67 12 implementation implementation NN cord-354035-i3sl2r0k 67 13 of of IN cord-354035-i3sl2r0k 67 14 the the DT cord-354035-i3sl2r0k 67 15 pneumococcal pneumococcal JJ cord-354035-i3sl2r0k 67 16 vaccine vaccine NN cord-354035-i3sl2r0k 67 17 . . . cord-354035-i3sl2r0k 68 1 Furthermore furthermore RB cord-354035-i3sl2r0k 68 2 , , , cord-354035-i3sl2r0k 68 3 it -PRON- PRP cord-354035-i3sl2r0k 68 4 is be VBZ cord-354035-i3sl2r0k 68 5 important important JJ cord-354035-i3sl2r0k 68 6 to to TO cord-354035-i3sl2r0k 68 7 note note VB cord-354035-i3sl2r0k 68 8 that that IN cord-354035-i3sl2r0k 68 9 no no DT cord-354035-i3sl2r0k 68 10 pathogen pathogen NN cord-354035-i3sl2r0k 68 11 was be VBD cord-354035-i3sl2r0k 68 12 detected detect VBN cord-354035-i3sl2r0k 68 13 in in IN cord-354035-i3sl2r0k 68 14 62 62 CD cord-354035-i3sl2r0k 68 15 % % NN cord-354035-i3sl2r0k 68 16 of of IN cord-354035-i3sl2r0k 68 17 adults adult NNS cord-354035-i3sl2r0k 68 18 and and CC cord-354035-i3sl2r0k 68 19 19 19 CD cord-354035-i3sl2r0k 68 20 % % NN cord-354035-i3sl2r0k 68 21 of of IN cord-354035-i3sl2r0k 68 22 children child NNS cord-354035-i3sl2r0k 68 23 , , , cord-354035-i3sl2r0k 68 24 suggesting suggest VBG cord-354035-i3sl2r0k 68 25 the the DT cord-354035-i3sl2r0k 68 26 possibility possibility NN cord-354035-i3sl2r0k 68 27 that that IN cord-354035-i3sl2r0k 68 28 pneumonia pneumonia NN cord-354035-i3sl2r0k 68 29 was be VBD cord-354035-i3sl2r0k 68 30 caused cause VBN cord-354035-i3sl2r0k 68 31 by by IN cord-354035-i3sl2r0k 68 32 viruses virus NNS cord-354035-i3sl2r0k 68 33 not not RB cord-354035-i3sl2r0k 68 34 included include VBN cord-354035-i3sl2r0k 68 35 in in IN cord-354035-i3sl2r0k 68 36 the the DT cord-354035-i3sl2r0k 68 37 set set NN cord-354035-i3sl2r0k 68 38 of of IN cord-354035-i3sl2r0k 68 39 targeted target VBN cord-354035-i3sl2r0k 68 40 assays assay NNS cord-354035-i3sl2r0k 68 41 used use VBN cord-354035-i3sl2r0k 68 42 in in IN cord-354035-i3sl2r0k 68 43 this this DT cord-354035-i3sl2r0k 68 44 study study NN cord-354035-i3sl2r0k 68 45 . . . cord-354035-i3sl2r0k 69 1 Identification identification NN cord-354035-i3sl2r0k 69 2 of of IN cord-354035-i3sl2r0k 69 3 the the DT cord-354035-i3sl2r0k 69 4 etiologic etiologic JJ cord-354035-i3sl2r0k 69 5 agent agent NN cord-354035-i3sl2r0k 69 6 of of IN cord-354035-i3sl2r0k 69 7 pneumonia pneumonia NN cord-354035-i3sl2r0k 69 8 may may MD cord-354035-i3sl2r0k 69 9 benefit benefit VB cord-354035-i3sl2r0k 69 10 from from IN cord-354035-i3sl2r0k 69 11 unbiased unbiased JJ cord-354035-i3sl2r0k 69 12 HTS HTS NNP cord-354035-i3sl2r0k 69 13 assays assay NNS cord-354035-i3sl2r0k 69 14 to to TO cord-354035-i3sl2r0k 69 15 detect detect VB cord-354035-i3sl2r0k 69 16 unexpected unexpected JJ cord-354035-i3sl2r0k 69 17 or or CC cord-354035-i3sl2r0k 69 18 rare rare JJ cord-354035-i3sl2r0k 69 19 pathogens pathogen NNS cord-354035-i3sl2r0k 69 20 that that WDT cord-354035-i3sl2r0k 69 21 are be VBP cord-354035-i3sl2r0k 69 22 not not RB cord-354035-i3sl2r0k 69 23 be be VB cord-354035-i3sl2r0k 69 24 included include VBN cord-354035-i3sl2r0k 69 25 in in IN cord-354035-i3sl2r0k 69 26 standard standard JJ cord-354035-i3sl2r0k 69 27 clinical clinical JJ cord-354035-i3sl2r0k 69 28 testing testing NN cord-354035-i3sl2r0k 69 29 . . . cord-354035-i3sl2r0k 70 1 In in IN cord-354035-i3sl2r0k 70 2 a a DT cord-354035-i3sl2r0k 70 3 study study NN cord-354035-i3sl2r0k 70 4 of of IN cord-354035-i3sl2r0k 70 5 children child NNS cord-354035-i3sl2r0k 70 6 with with IN cord-354035-i3sl2r0k 70 7 unexplained unexplained JJ cord-354035-i3sl2r0k 70 8 fever fever NN cord-354035-i3sl2r0k 70 9 , , , cord-354035-i3sl2r0k 70 10 both both DT cord-354035-i3sl2r0k 70 11 targeted target VBN cord-354035-i3sl2r0k 70 12 PCR PCR NNP cord-354035-i3sl2r0k 70 13 assays assay NNS cord-354035-i3sl2r0k 70 14 8 8 CD cord-354035-i3sl2r0k 70 15 _SP cord-354035-i3sl2r0k 71 1 Although although IN cord-354035-i3sl2r0k 71 2 many many JJ cord-354035-i3sl2r0k 71 3 viral viral JJ cord-354035-i3sl2r0k 71 4 infections infection NNS cord-354035-i3sl2r0k 71 5 are be VBP cord-354035-i3sl2r0k 71 6 mild mild JJ cord-354035-i3sl2r0k 71 7 or or CC cord-354035-i3sl2r0k 71 8 resolve resolve VB cord-354035-i3sl2r0k 71 9 without without IN cord-354035-i3sl2r0k 71 10 complication complication NN cord-354035-i3sl2r0k 71 11 in in IN cord-354035-i3sl2r0k 71 12 generally generally RB cord-354035-i3sl2r0k 71 13 healthy healthy JJ cord-354035-i3sl2r0k 71 14 individuals individual NNS cord-354035-i3sl2r0k 71 15 , , , cord-354035-i3sl2r0k 71 16 viruses virus NNS cord-354035-i3sl2r0k 71 17 in in IN cord-354035-i3sl2r0k 71 18 the the DT cord-354035-i3sl2r0k 71 19 respiratory respiratory JJ cord-354035-i3sl2r0k 71 20 tract tract NN cord-354035-i3sl2r0k 71 21 are be VBP cord-354035-i3sl2r0k 71 22 associated associate VBN cord-354035-i3sl2r0k 71 23 with with IN cord-354035-i3sl2r0k 71 24 exacerbations exacerbation NNS cord-354035-i3sl2r0k 71 25 of of IN cord-354035-i3sl2r0k 71 26 chronic chronic JJ cord-354035-i3sl2r0k 71 27 lung lung NN cord-354035-i3sl2r0k 71 28 diseases disease NNS cord-354035-i3sl2r0k 71 29 , , , cord-354035-i3sl2r0k 71 30 including include VBG cord-354035-i3sl2r0k 71 31 CF cf NN cord-354035-i3sl2r0k 71 32 , , , cord-354035-i3sl2r0k 71 33 chronic chronic JJ cord-354035-i3sl2r0k 71 34 obstructive obstructive JJ cord-354035-i3sl2r0k 71 35 pulmonary pulmonary JJ cord-354035-i3sl2r0k 71 36 disease disease NN cord-354035-i3sl2r0k 71 37 , , , cord-354035-i3sl2r0k 71 38 and and CC cord-354035-i3sl2r0k 71 39 asthma asthma NN cord-354035-i3sl2r0k 71 40 ( ( -LRB- cord-354035-i3sl2r0k 71 41 reviewed review VBN cord-354035-i3sl2r0k 71 42 in in IN cord-354035-i3sl2r0k 71 43 the the DT cord-354035-i3sl2r0k 71 44 following follow VBG cord-354035-i3sl2r0k 71 45 11 11 CD cord-354035-i3sl2r0k 71 46 , , , cord-354035-i3sl2r0k 71 47 12 12 CD cord-354035-i3sl2r0k 71 48 ) ) -RRB- cord-354035-i3sl2r0k 71 49 . . . cord-354035-i3sl2r0k 72 1 Exploration exploration NN cord-354035-i3sl2r0k 72 2 of of IN cord-354035-i3sl2r0k 72 3 the the DT cord-354035-i3sl2r0k 72 4 virome virome NN cord-354035-i3sl2r0k 72 5 in in IN cord-354035-i3sl2r0k 72 6 the the DT cord-354035-i3sl2r0k 72 7 respiratory respiratory JJ cord-354035-i3sl2r0k 72 8 tracts tract NNS cord-354035-i3sl2r0k 72 9 of of IN cord-354035-i3sl2r0k 72 10 patients patient NNS cord-354035-i3sl2r0k 72 11 with with IN cord-354035-i3sl2r0k 72 12 chronic chronic JJ cord-354035-i3sl2r0k 72 13 lung lung NN cord-354035-i3sl2r0k 72 14 diseases disease NNS cord-354035-i3sl2r0k 72 15 has have VBZ cord-354035-i3sl2r0k 72 16 emphasized emphasize VBN cord-354035-i3sl2r0k 72 17 the the DT cord-354035-i3sl2r0k 72 18 prevalence prevalence NN cord-354035-i3sl2r0k 72 19 of of IN cord-354035-i3sl2r0k 72 20 common common JJ cord-354035-i3sl2r0k 72 21 pathogens pathogen NNS cord-354035-i3sl2r0k 72 22 and and CC cord-354035-i3sl2r0k 72 23 also also RB cord-354035-i3sl2r0k 72 24 further further RB cord-354035-i3sl2r0k 72 25 defines define VBZ cord-354035-i3sl2r0k 72 26 the the DT cord-354035-i3sl2r0k 72 27 scope scope NN cord-354035-i3sl2r0k 72 28 of of IN cord-354035-i3sl2r0k 72 29 the the DT cord-354035-i3sl2r0k 72 30 respiratory respiratory JJ cord-354035-i3sl2r0k 72 31 tract tract NN cord-354035-i3sl2r0k 72 32 virome virome NN cord-354035-i3sl2r0k 72 33 . . . cord-354035-i3sl2r0k 73 1 To to TO cord-354035-i3sl2r0k 73 2 illustrate illustrate VB cord-354035-i3sl2r0k 73 3 this this DT cord-354035-i3sl2r0k 73 4 point point NN cord-354035-i3sl2r0k 73 5 , , , cord-354035-i3sl2r0k 73 6 the the DT cord-354035-i3sl2r0k 73 7 author author NN cord-354035-i3sl2r0k 73 8 discusses discuss VBZ cord-354035-i3sl2r0k 73 9 a a DT cord-354035-i3sl2r0k 73 10 few few JJ cord-354035-i3sl2r0k 73 11 studies study NNS cord-354035-i3sl2r0k 73 12 of of IN cord-354035-i3sl2r0k 73 13 the the DT cord-354035-i3sl2r0k 73 14 virome virome NNP cord-354035-i3sl2r0k 73 15 in in IN cord-354035-i3sl2r0k 73 16 patients patient NNS cord-354035-i3sl2r0k 73 17 with with IN cord-354035-i3sl2r0k 73 18 CF CF NNP cord-354035-i3sl2r0k 73 19 . . . cord-354035-i3sl2r0k 74 1 Molecular molecular JJ cord-354035-i3sl2r0k 74 2 methods method NNS cord-354035-i3sl2r0k 74 3 of of IN cord-354035-i3sl2r0k 74 4 detection detection NN cord-354035-i3sl2r0k 74 5 , , , cord-354035-i3sl2r0k 74 6 specifically specifically RB cord-354035-i3sl2r0k 74 7 PCR PCR NNP cord-354035-i3sl2r0k 74 8 assays assay NNS cord-354035-i3sl2r0k 74 9 , , , cord-354035-i3sl2r0k 74 10 have have VBP cord-354035-i3sl2r0k 74 11 increased increase VBN cord-354035-i3sl2r0k 74 12 the the DT cord-354035-i3sl2r0k 74 13 association association NN cord-354035-i3sl2r0k 74 14 of of IN cord-354035-i3sl2r0k 74 15 viral viral JJ cord-354035-i3sl2r0k 74 16 infection infection NN cord-354035-i3sl2r0k 74 17 with with IN cord-354035-i3sl2r0k 74 18 pulmonary pulmonary JJ cord-354035-i3sl2r0k 74 19 exacerbation exacerbation NN cord-354035-i3sl2r0k 74 20 . . . cord-354035-i3sl2r0k 75 1 Incidence incidence NN cord-354035-i3sl2r0k 75 2 of of IN cord-354035-i3sl2r0k 75 3 viral viral JJ cord-354035-i3sl2r0k 75 4 infections infection NNS cord-354035-i3sl2r0k 75 5 in in IN cord-354035-i3sl2r0k 75 6 adult adult NN cord-354035-i3sl2r0k 75 7 patients patient NNS cord-354035-i3sl2r0k 75 8 with with IN cord-354035-i3sl2r0k 75 9 CF CF NNP cord-354035-i3sl2r0k 75 10 was be VBD cord-354035-i3sl2r0k 75 11 estimated estimate VBN cord-354035-i3sl2r0k 75 12 at at IN cord-354035-i3sl2r0k 75 13 1 1 CD cord-354035-i3sl2r0k 75 14 to to IN cord-354035-i3sl2r0k 75 15 2 2 CD cord-354035-i3sl2r0k 75 16 viral viral JJ cord-354035-i3sl2r0k 75 17 infections infection NNS cord-354035-i3sl2r0k 75 18 per per IN cord-354035-i3sl2r0k 75 19 year year NN cord-354035-i3sl2r0k 75 20 based base VBN cord-354035-i3sl2r0k 75 21 on on IN cord-354035-i3sl2r0k 75 22 a a DT cord-354035-i3sl2r0k 75 23 study study NN cord-354035-i3sl2r0k 75 24 of of IN cord-354035-i3sl2r0k 75 25 100 100 CD cord-354035-i3sl2r0k 75 26 patients patient NNS cord-354035-i3sl2r0k 75 27 who who WP cord-354035-i3sl2r0k 75 28 were be VBD cord-354035-i3sl2r0k 75 29 sampled sample VBN cord-354035-i3sl2r0k 75 30 every every DT cord-354035-i3sl2r0k 75 31 2 2 CD cord-354035-i3sl2r0k 75 32 months month NNS cord-354035-i3sl2r0k 75 33 for for IN cord-354035-i3sl2r0k 75 34 a a DT cord-354035-i3sl2r0k 75 35 year year NN cord-354035-i3sl2r0k 75 36 and and CC cord-354035-i3sl2r0k 75 37 on on IN cord-354035-i3sl2r0k 75 38 exacerbation exacerbation NN cord-354035-i3sl2r0k 75 39 . . . cord-354035-i3sl2r0k 76 1 13 13 CD cord-354035-i3sl2r0k 76 2 Samples sample NNS cord-354035-i3sl2r0k 76 3 from from IN cord-354035-i3sl2r0k 76 4 the the DT cord-354035-i3sl2r0k 76 5 respiratory respiratory JJ cord-354035-i3sl2r0k 76 6 tract tract NN cord-354035-i3sl2r0k 76 7 ( ( -LRB- cord-354035-i3sl2r0k 76 8 sputum sputum NN cord-354035-i3sl2r0k 76 9 , , , cord-354035-i3sl2r0k 76 10 nose nose NN cord-354035-i3sl2r0k 76 11 and and CC cord-354035-i3sl2r0k 76 12 throat throat NN cord-354035-i3sl2r0k 76 13 swabs swab NNS cord-354035-i3sl2r0k 76 14 ) ) -RRB- cord-354035-i3sl2r0k 76 15 were be VBD cord-354035-i3sl2r0k 76 16 tested test VBN cord-354035-i3sl2r0k 76 17 using use VBG cord-354035-i3sl2r0k 76 18 PCR PCR NNP cord-354035-i3sl2r0k 76 19 assays assay NNS cord-354035-i3sl2r0k 76 20 for for IN cord-354035-i3sl2r0k 76 21 common common JJ cord-354035-i3sl2r0k 76 22 respiratory respiratory JJ cord-354035-i3sl2r0k 76 23 pathogens pathogen NNS cord-354035-i3sl2r0k 76 24 , , , cord-354035-i3sl2r0k 76 25 including include VBG cord-354035-i3sl2r0k 76 26 respiratory respiratory JJ cord-354035-i3sl2r0k 76 27 syncytial syncytial JJ cord-354035-i3sl2r0k 76 28 virus virus NN cord-354035-i3sl2r0k 76 29 , , , cord-354035-i3sl2r0k 76 30 rhinovirus rhinovirus NN cord-354035-i3sl2r0k 76 31 , , , cord-354035-i3sl2r0k 76 32 influenza influenza NN cord-354035-i3sl2r0k 76 33 virus virus NN cord-354035-i3sl2r0k 76 34 , , , cord-354035-i3sl2r0k 76 35 and and CC cord-354035-i3sl2r0k 76 36 others other NNS cord-354035-i3sl2r0k 76 37 . . . cord-354035-i3sl2r0k 77 1 Rhinovirus Rhinovirus NNP cord-354035-i3sl2r0k 77 2 and and CC cord-354035-i3sl2r0k 77 3 metapneumovirus metapneumovirus NNP cord-354035-i3sl2r0k 77 4 were be VBD cord-354035-i3sl2r0k 77 5 the the DT cord-354035-i3sl2r0k 77 6 most most RBS cord-354035-i3sl2r0k 77 7 commonly commonly RB cord-354035-i3sl2r0k 77 8 detected detect VBN cord-354035-i3sl2r0k 77 9 viruses virus NNS cord-354035-i3sl2r0k 77 10 , , , cord-354035-i3sl2r0k 77 11 accounting account VBG cord-354035-i3sl2r0k 77 12 for for IN cord-354035-i3sl2r0k 77 13 72.5 72.5 CD cord-354035-i3sl2r0k 77 14 % % NN cord-354035-i3sl2r0k 77 15 and and CC cord-354035-i3sl2r0k 77 16 13.2 13.2 CD cord-354035-i3sl2r0k 77 17 % % NN cord-354035-i3sl2r0k 77 18 of of IN cord-354035-i3sl2r0k 77 19 virus virus NN cord-354035-i3sl2r0k 77 20 - - HYPH cord-354035-i3sl2r0k 77 21 positive positive JJ cord-354035-i3sl2r0k 77 22 samples sample NNS cord-354035-i3sl2r0k 77 23 , , , cord-354035-i3sl2r0k 77 24 respectively respectively RB cord-354035-i3sl2r0k 77 25 . . . cord-354035-i3sl2r0k 78 1 Viral viral JJ cord-354035-i3sl2r0k 78 2 infection infection NN cord-354035-i3sl2r0k 78 3 was be VBD cord-354035-i3sl2r0k 78 4 associated associate VBN cord-354035-i3sl2r0k 78 5 with with IN cord-354035-i3sl2r0k 78 6 pulmonary pulmonary JJ cord-354035-i3sl2r0k 78 7 exacerbation exacerbation NN cord-354035-i3sl2r0k 78 8 , , , cord-354035-i3sl2r0k 78 9 with with IN cord-354035-i3sl2r0k 78 10 virus virus NN cord-354035-i3sl2r0k 78 11 detected detect VBN cord-354035-i3sl2r0k 78 12 in in IN cord-354035-i3sl2r0k 78 13 40 40 CD cord-354035-i3sl2r0k 78 14 % % NN cord-354035-i3sl2r0k 78 15 of of IN cord-354035-i3sl2r0k 78 16 exacerbation exacerbation NN cord-354035-i3sl2r0k 78 17 samples sample NNS cord-354035-i3sl2r0k 78 18 compared compare VBN cord-354035-i3sl2r0k 78 19 with with IN cord-354035-i3sl2r0k 78 20 24 24 CD cord-354035-i3sl2r0k 78 21 % % NN cord-354035-i3sl2r0k 78 22 of of IN cord-354035-i3sl2r0k 78 23 samples sample NNS cord-354035-i3sl2r0k 78 24 collected collect VBN cord-354035-i3sl2r0k 78 25 on on IN cord-354035-i3sl2r0k 78 26 regular regular JJ cord-354035-i3sl2r0k 78 27 visits visit NNS cord-354035-i3sl2r0k 78 28 . . . cord-354035-i3sl2r0k 79 1 In in IN cord-354035-i3sl2r0k 79 2 another another DT cord-354035-i3sl2r0k 79 3 study study NN cord-354035-i3sl2r0k 79 4 , , , cord-354035-i3sl2r0k 79 5 sputum sputum NN cord-354035-i3sl2r0k 79 6 was be VBD cord-354035-i3sl2r0k 79 7 collected collect VBN cord-354035-i3sl2r0k 79 8 from from IN cord-354035-i3sl2r0k 79 9 46 46 CD cord-354035-i3sl2r0k 79 10 adult adult NN cord-354035-i3sl2r0k 79 11 patients patient NNS cord-354035-i3sl2r0k 79 12 and and CC cord-354035-i3sl2r0k 79 13 viruses virus NNS cord-354035-i3sl2r0k 79 14 were be VBD cord-354035-i3sl2r0k 79 15 screened screen VBN cord-354035-i3sl2r0k 79 16 using use VBG cord-354035-i3sl2r0k 79 17 PCR PCR NNP cord-354035-i3sl2r0k 79 18 assays assay NNS cord-354035-i3sl2r0k 79 19 . . . cord-354035-i3sl2r0k 80 1 14 14 CD cord-354035-i3sl2r0k 81 1 In in IN cord-354035-i3sl2r0k 81 2 this this DT cord-354035-i3sl2r0k 81 3 study study NN cord-354035-i3sl2r0k 81 4 , , , cord-354035-i3sl2r0k 81 5 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 81 6 and and CC cord-354035-i3sl2r0k 81 7 coronaviruses coronaviruse NNS cord-354035-i3sl2r0k 81 8 were be VBD cord-354035-i3sl2r0k 81 9 the the DT cord-354035-i3sl2r0k 81 10 most most RBS cord-354035-i3sl2r0k 81 11 common common JJ cord-354035-i3sl2r0k 81 12 viruses virus NNS cord-354035-i3sl2r0k 81 13 , , , cord-354035-i3sl2r0k 81 14 and and CC cord-354035-i3sl2r0k 81 15 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 81 16 were be VBD cord-354035-i3sl2r0k 81 17 associated associate VBN cord-354035-i3sl2r0k 81 18 with with IN cord-354035-i3sl2r0k 81 19 exacerbation exacerbation NN cord-354035-i3sl2r0k 81 20 . . . cord-354035-i3sl2r0k 82 1 In in IN cord-354035-i3sl2r0k 82 2 children child NNS cord-354035-i3sl2r0k 82 3 with with IN cord-354035-i3sl2r0k 82 4 CF CF NNP cord-354035-i3sl2r0k 82 5 , , , cord-354035-i3sl2r0k 82 6 exacerbation exacerbation NN cord-354035-i3sl2r0k 82 7 has have VBZ cord-354035-i3sl2r0k 82 8 also also RB cord-354035-i3sl2r0k 82 9 been be VBN cord-354035-i3sl2r0k 82 10 associated associate VBN cord-354035-i3sl2r0k 82 11 with with IN cord-354035-i3sl2r0k 82 12 viral viral JJ cord-354035-i3sl2r0k 82 13 infection infection NN cord-354035-i3sl2r0k 82 14 . . . cord-354035-i3sl2r0k 83 1 In in IN cord-354035-i3sl2r0k 83 2 a a DT cord-354035-i3sl2r0k 83 3 study study NN cord-354035-i3sl2r0k 83 4 of of IN cord-354035-i3sl2r0k 83 5 71 71 CD cord-354035-i3sl2r0k 83 6 patients patient NNS cord-354035-i3sl2r0k 83 7 , , , cord-354035-i3sl2r0k 83 8 viruses virus NNS cord-354035-i3sl2r0k 83 9 were be VBD cord-354035-i3sl2r0k 83 10 assessed assess VBN cord-354035-i3sl2r0k 83 11 in in IN cord-354035-i3sl2r0k 83 12 nasal nasal NN cord-354035-i3sl2r0k 83 13 swabs swab NNS cord-354035-i3sl2r0k 83 14 using use VBG cord-354035-i3sl2r0k 83 15 a a DT cord-354035-i3sl2r0k 83 16 panel panel NN cord-354035-i3sl2r0k 83 17 of of IN cord-354035-i3sl2r0k 83 18 targeted target VBN cord-354035-i3sl2r0k 83 19 PCR PCR NNP cord-354035-i3sl2r0k 83 20 assays assay NNS cord-354035-i3sl2r0k 83 21 for for IN cord-354035-i3sl2r0k 83 22 common common JJ cord-354035-i3sl2r0k 83 23 respiratory respiratory JJ cord-354035-i3sl2r0k 83 24 pathogens pathogen NNS cord-354035-i3sl2r0k 83 25 . . . cord-354035-i3sl2r0k 84 1 15 15 CD cord-354035-i3sl2r0k 84 2 Viruses virus NNS cord-354035-i3sl2r0k 84 3 were be VBD cord-354035-i3sl2r0k 84 4 detected detect VBN cord-354035-i3sl2r0k 84 5 in in IN cord-354035-i3sl2r0k 84 6 46 46 CD cord-354035-i3sl2r0k 84 7 % % NN cord-354035-i3sl2r0k 84 8 of of IN cord-354035-i3sl2r0k 84 9 samples sample NNS cord-354035-i3sl2r0k 84 10 collected collect VBN cord-354035-i3sl2r0k 84 11 during during IN cord-354035-i3sl2r0k 84 12 exacerbation exacerbation NN cord-354035-i3sl2r0k 84 13 but but CC cord-354035-i3sl2r0k 84 14 only only RB cord-354035-i3sl2r0k 84 15 17 17 CD cord-354035-i3sl2r0k 84 16 % % NN cord-354035-i3sl2r0k 84 17 of of IN cord-354035-i3sl2r0k 84 18 samples sample NNS cord-354035-i3sl2r0k 84 19 collected collect VBN cord-354035-i3sl2r0k 84 20 when when WRB cord-354035-i3sl2r0k 84 21 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 84 22 . . . cord-354035-i3sl2r0k 85 1 Influenza Influenza NNP cord-354035-i3sl2r0k 85 2 A A NNP cord-354035-i3sl2r0k 85 3 , , , cord-354035-i3sl2r0k 85 4 influenza influenza NN cord-354035-i3sl2r0k 85 5 B b NN cord-354035-i3sl2r0k 85 6 , , , cord-354035-i3sl2r0k 85 7 and and CC cord-354035-i3sl2r0k 85 8 rhinovirus rhinovirus NN cord-354035-i3sl2r0k 85 9 were be VBD cord-354035-i3sl2r0k 85 10 all all DT cord-354035-i3sl2r0k 85 11 associated associate VBN cord-354035-i3sl2r0k 85 12 with with IN cord-354035-i3sl2r0k 85 13 exacerbation exacerbation NN cord-354035-i3sl2r0k 85 14 . . . cord-354035-i3sl2r0k 86 1 The the DT cord-354035-i3sl2r0k 86 2 virome virome NN cord-354035-i3sl2r0k 86 3 of of IN cord-354035-i3sl2r0k 86 4 patients patient NNS cord-354035-i3sl2r0k 86 5 with with IN cord-354035-i3sl2r0k 86 6 CF CF NNP cord-354035-i3sl2r0k 86 7 has have VBZ cord-354035-i3sl2r0k 86 8 also also RB cord-354035-i3sl2r0k 86 9 been be VBN cord-354035-i3sl2r0k 86 10 characterized characterize VBN cord-354035-i3sl2r0k 86 11 using use VBG cord-354035-i3sl2r0k 86 12 HTS HTS NNP cord-354035-i3sl2r0k 86 13 . . . cord-354035-i3sl2r0k 87 1 One one CD cord-354035-i3sl2r0k 87 2 study study NN cord-354035-i3sl2r0k 87 3 aimed aim VBN cord-354035-i3sl2r0k 87 4 to to TO cord-354035-i3sl2r0k 87 5 study study VB cord-354035-i3sl2r0k 87 6 the the DT cord-354035-i3sl2r0k 87 7 virome virome NN cord-354035-i3sl2r0k 87 8 in in IN cord-354035-i3sl2r0k 87 9 sputum sputum NN cord-354035-i3sl2r0k 87 10 from from IN cord-354035-i3sl2r0k 87 11 5 5 CD cord-354035-i3sl2r0k 87 12 patients patient NNS cord-354035-i3sl2r0k 87 13 with with IN cord-354035-i3sl2r0k 87 14 CF CF NNP cord-354035-i3sl2r0k 87 15 and and CC cord-354035-i3sl2r0k 87 16 5 5 CD cord-354035-i3sl2r0k 87 17 healthy healthy JJ cord-354035-i3sl2r0k 87 18 controls control NNS cord-354035-i3sl2r0k 87 19 . . . cord-354035-i3sl2r0k 88 1 16 16 CD cord-354035-i3sl2r0k 88 2 Virus virus NN cord-354035-i3sl2r0k 88 3 particles particle NNS cord-354035-i3sl2r0k 88 4 were be VBD cord-354035-i3sl2r0k 88 5 enriched enrich VBN cord-354035-i3sl2r0k 88 6 , , , cord-354035-i3sl2r0k 88 7 and and CC cord-354035-i3sl2r0k 88 8 DNA dna NN cord-354035-i3sl2r0k 88 9 viruses virus NNS cord-354035-i3sl2r0k 88 10 were be VBD cord-354035-i3sl2r0k 88 11 sequenced sequence VBN cord-354035-i3sl2r0k 88 12 . . . cord-354035-i3sl2r0k 89 1 This this DT cord-354035-i3sl2r0k 89 2 study study NN cord-354035-i3sl2r0k 89 3 was be VBD cord-354035-i3sl2r0k 89 4 particularly particularly RB cord-354035-i3sl2r0k 89 5 interesting interesting JJ cord-354035-i3sl2r0k 89 6 because because IN cord-354035-i3sl2r0k 89 7 the the DT cord-354035-i3sl2r0k 89 8 use use NN cord-354035-i3sl2r0k 89 9 of of IN cord-354035-i3sl2r0k 89 10 HTS HTS NNP cord-354035-i3sl2r0k 89 11 instead instead RB cord-354035-i3sl2r0k 89 12 of of IN cord-354035-i3sl2r0k 89 13 targeted target VBN cord-354035-i3sl2r0k 89 14 PCR PCR NNP cord-354035-i3sl2r0k 89 15 assays assay NNS cord-354035-i3sl2r0k 89 16 resulted result VBD cord-354035-i3sl2r0k 89 17 in in IN cord-354035-i3sl2r0k 89 18 the the DT cord-354035-i3sl2r0k 89 19 detection detection NN cord-354035-i3sl2r0k 89 20 of of IN cord-354035-i3sl2r0k 89 21 viruses virus NNS cord-354035-i3sl2r0k 89 22 that that WDT cord-354035-i3sl2r0k 89 23 would would MD cord-354035-i3sl2r0k 89 24 not not RB cord-354035-i3sl2r0k 89 25 have have VB cord-354035-i3sl2r0k 89 26 been be VBN cord-354035-i3sl2r0k 89 27 included include VBN cord-354035-i3sl2r0k 89 28 in in IN cord-354035-i3sl2r0k 89 29 typical typical JJ cord-354035-i3sl2r0k 89 30 PCR PCR NNP cord-354035-i3sl2r0k 89 31 panels panel NNS cord-354035-i3sl2r0k 89 32 evaluating evaluate VBG cord-354035-i3sl2r0k 89 33 respiratory respiratory JJ cord-354035-i3sl2r0k 89 34 viruses virus NNS cord-354035-i3sl2r0k 89 35 . . . cord-354035-i3sl2r0k 90 1 In in IN cord-354035-i3sl2r0k 90 2 the the DT cord-354035-i3sl2r0k 90 3 patients patient NNS cord-354035-i3sl2r0k 90 4 with with IN cord-354035-i3sl2r0k 90 5 CF CF NNP cord-354035-i3sl2r0k 90 6 , , , cord-354035-i3sl2r0k 90 7 reticuloendotheliosis reticuloendotheliosis NN cord-354035-i3sl2r0k 90 8 virus virus NN cord-354035-i3sl2r0k 90 9 , , , cord-354035-i3sl2r0k 90 10 Epstein Epstein NNP cord-354035-i3sl2r0k 90 11 - - HYPH cord-354035-i3sl2r0k 90 12 Barr Barr NNP cord-354035-i3sl2r0k 90 13 virus virus NN cord-354035-i3sl2r0k 90 14 , , , cord-354035-i3sl2r0k 90 15 human human JJ cord-354035-i3sl2r0k 90 16 herpesvirus herpesvirus NN cord-354035-i3sl2r0k 90 17 6B 6b CD cord-354035-i3sl2r0k 90 18 , , , cord-354035-i3sl2r0k 90 19 and and CC cord-354035-i3sl2r0k 90 20 human human JJ cord-354035-i3sl2r0k 90 21 herpesvirus herpesvirus NN cord-354035-i3sl2r0k 90 22 8 8 CD cord-354035-i3sl2r0k 90 23 were be VBD cord-354035-i3sl2r0k 90 24 detected detect VBN cord-354035-i3sl2r0k 90 25 . . . cord-354035-i3sl2r0k 91 1 In in IN cord-354035-i3sl2r0k 91 2 control control NN cord-354035-i3sl2r0k 91 3 patients patient NNS cord-354035-i3sl2r0k 91 4 , , , cord-354035-i3sl2r0k 91 5 human human JJ cord-354035-i3sl2r0k 91 6 papillomaviruses papillomaviruse NNS cord-354035-i3sl2r0k 91 7 were be VBD cord-354035-i3sl2r0k 91 8 detected detect VBN cord-354035-i3sl2r0k 91 9 in in IN cord-354035-i3sl2r0k 91 10 2 2 CD cord-354035-i3sl2r0k 91 11 samples sample NNS cord-354035-i3sl2r0k 91 12 . . . cord-354035-i3sl2r0k 92 1 Several several JJ cord-354035-i3sl2r0k 92 2 single single JJ cord-354035-i3sl2r0k 92 3 - - HYPH cord-354035-i3sl2r0k 92 4 stranded strand VBN cord-354035-i3sl2r0k 92 5 DNA dna NN cord-354035-i3sl2r0k 92 6 viruses virus NNS cord-354035-i3sl2r0k 92 7 were be VBD cord-354035-i3sl2r0k 92 8 also also RB cord-354035-i3sl2r0k 92 9 detected detect VBN cord-354035-i3sl2r0k 92 10 in in IN cord-354035-i3sl2r0k 92 11 patients patient NNS cord-354035-i3sl2r0k 92 12 and/or and/or CC cord-354035-i3sl2r0k 92 13 controls control NNS cord-354035-i3sl2r0k 92 14 , , , cord-354035-i3sl2r0k 92 15 including include VBG cord-354035-i3sl2r0k 92 16 geminiviruses geminiviruse NNS cord-354035-i3sl2r0k 92 17 and and CC cord-354035-i3sl2r0k 92 18 circoviruses circoviruse NNS cord-354035-i3sl2r0k 92 19 . . . cord-354035-i3sl2r0k 93 1 In in IN cord-354035-i3sl2r0k 93 2 a a DT cord-354035-i3sl2r0k 93 3 second second JJ cord-354035-i3sl2r0k 93 4 study study NN cord-354035-i3sl2r0k 93 5 , , , cord-354035-i3sl2r0k 93 6 the the DT cord-354035-i3sl2r0k 93 7 virome virome NN cord-354035-i3sl2r0k 93 8 was be VBD cord-354035-i3sl2r0k 93 9 assessed assess VBN cord-354035-i3sl2r0k 93 10 in in IN cord-354035-i3sl2r0k 93 11 explanted explanted JJ cord-354035-i3sl2r0k 93 12 lungs lung NNS cord-354035-i3sl2r0k 93 13 from from IN cord-354035-i3sl2r0k 93 14 patients patient NNS cord-354035-i3sl2r0k 93 15 with with IN cord-354035-i3sl2r0k 93 16 CF cf NN cord-354035-i3sl2r0k 93 17 undergoing undergo VBG cord-354035-i3sl2r0k 93 18 lung lung NN cord-354035-i3sl2r0k 93 19 transplant transplant NN cord-354035-i3sl2r0k 93 20 and and CC cord-354035-i3sl2r0k 93 21 lungs lung NNS cord-354035-i3sl2r0k 93 22 obtained obtain VBD cord-354035-i3sl2r0k 93 23 post post AFX cord-354035-i3sl2r0k 93 24 mortem mortem NN cord-354035-i3sl2r0k 93 25 . . . cord-354035-i3sl2r0k 94 1 3 3 CD cord-354035-i3sl2r0k 94 2 Anelloviruses Anelloviruses NNP cord-354035-i3sl2r0k 94 3 , , , cord-354035-i3sl2r0k 94 4 papillomaviruses papillomaviruse NNS cord-354035-i3sl2r0k 94 5 , , , cord-354035-i3sl2r0k 94 6 and and CC cord-354035-i3sl2r0k 94 7 herpesviruses herpesviruses NNP cord-354035-i3sl2r0k 94 8 were be VBD cord-354035-i3sl2r0k 94 9 detected detect VBN cord-354035-i3sl2r0k 94 10 ; ; : cord-354035-i3sl2r0k 94 11 viruses virus NNS cord-354035-i3sl2r0k 94 12 were be VBD cord-354035-i3sl2r0k 94 13 detected detect VBN cord-354035-i3sl2r0k 94 14 in in IN cord-354035-i3sl2r0k 94 15 distinct distinct JJ cord-354035-i3sl2r0k 94 16 regions region NNS cord-354035-i3sl2r0k 94 17 of of IN cord-354035-i3sl2r0k 94 18 the the DT cord-354035-i3sl2r0k 94 19 lung lung NN cord-354035-i3sl2r0k 94 20 rather rather RB cord-354035-i3sl2r0k 94 21 than than IN cord-354035-i3sl2r0k 94 22 diffusely diffusely RB cord-354035-i3sl2r0k 94 23 throughout throughout RB cord-354035-i3sl2r0k 94 24 . . . cord-354035-i3sl2r0k 95 1 These these DT cord-354035-i3sl2r0k 95 2 studies study NNS cord-354035-i3sl2r0k 95 3 were be VBD cord-354035-i3sl2r0k 95 4 valuable valuable JJ cord-354035-i3sl2r0k 95 5 because because IN cord-354035-i3sl2r0k 95 6 many many JJ cord-354035-i3sl2r0k 95 7 of of IN cord-354035-i3sl2r0k 95 8 the the DT cord-354035-i3sl2r0k 95 9 viruses virus NNS cord-354035-i3sl2r0k 95 10 detected detect VBN cord-354035-i3sl2r0k 95 11 were be VBD cord-354035-i3sl2r0k 95 12 not not RB cord-354035-i3sl2r0k 95 13 those those DT cord-354035-i3sl2r0k 95 14 that that WDT cord-354035-i3sl2r0k 95 15 would would MD cord-354035-i3sl2r0k 95 16 have have VB cord-354035-i3sl2r0k 95 17 been be VBN cord-354035-i3sl2r0k 95 18 included include VBN cord-354035-i3sl2r0k 95 19 in in IN cord-354035-i3sl2r0k 95 20 PCR PCR NNP cord-354035-i3sl2r0k 95 21 screens screen NNS cord-354035-i3sl2r0k 95 22 for for IN cord-354035-i3sl2r0k 95 23 common common JJ cord-354035-i3sl2r0k 95 24 respiratory respiratory JJ cord-354035-i3sl2r0k 95 25 pathogens pathogen NNS cord-354035-i3sl2r0k 95 26 , , , cord-354035-i3sl2r0k 95 27 yet yet CC cord-354035-i3sl2r0k 95 28 they -PRON- PRP cord-354035-i3sl2r0k 95 29 may may MD cord-354035-i3sl2r0k 95 30 impact impact VB cord-354035-i3sl2r0k 95 31 disease disease NN cord-354035-i3sl2r0k 95 32 progression progression NN cord-354035-i3sl2r0k 95 33 in in IN cord-354035-i3sl2r0k 95 34 the the DT cord-354035-i3sl2r0k 95 35 lung lung NN cord-354035-i3sl2r0k 95 36 by by IN cord-354035-i3sl2r0k 95 37 creating create VBG cord-354035-i3sl2r0k 95 38 or or CC cord-354035-i3sl2r0k 95 39 promoting promote VBG cord-354035-i3sl2r0k 95 40 inflammation inflammation NN cord-354035-i3sl2r0k 95 41 in in IN cord-354035-i3sl2r0k 95 42 the the DT cord-354035-i3sl2r0k 95 43 respiratory respiratory JJ cord-354035-i3sl2r0k 95 44 tract tract NN cord-354035-i3sl2r0k 95 45 . . . cord-354035-i3sl2r0k 96 1 In in IN cord-354035-i3sl2r0k 96 2 one one CD cord-354035-i3sl2r0k 96 3 study study NN cord-354035-i3sl2r0k 96 4 , , , cord-354035-i3sl2r0k 96 5 the the DT cord-354035-i3sl2r0k 96 6 virome virome NN cord-354035-i3sl2r0k 96 7 was be VBD cord-354035-i3sl2r0k 96 8 studied study VBN cord-354035-i3sl2r0k 96 9 in in IN cord-354035-i3sl2r0k 96 10 bronchoalveolar bronchoalveolar NNP cord-354035-i3sl2r0k 96 11 lavage lavage NN cord-354035-i3sl2r0k 96 12 and and CC cord-354035-i3sl2r0k 96 13 oral oral JJ cord-354035-i3sl2r0k 96 14 washes wash NNS cord-354035-i3sl2r0k 96 15 from from IN cord-354035-i3sl2r0k 96 16 lung lung NN cord-354035-i3sl2r0k 96 17 transplant transplant NN cord-354035-i3sl2r0k 96 18 patients patient NNS cord-354035-i3sl2r0k 96 19 within within IN cord-354035-i3sl2r0k 96 20 the the DT cord-354035-i3sl2r0k 96 21 first first JJ cord-354035-i3sl2r0k 96 22 year year NN cord-354035-i3sl2r0k 96 23 of of IN cord-354035-i3sl2r0k 96 24 transplant transplant NN cord-354035-i3sl2r0k 96 25 , , , cord-354035-i3sl2r0k 96 26 human human JJ cord-354035-i3sl2r0k 96 27 immunodeficiency immunodeficiency NN cord-354035-i3sl2r0k 96 28 virus virus NN cord-354035-i3sl2r0k 96 29 ( ( -LRB- cord-354035-i3sl2r0k 96 30 HIV HIV NNP cord-354035-i3sl2r0k 96 31 ) ) -RRB- cord-354035-i3sl2r0k 96 32 positive positive JJ cord-354035-i3sl2r0k 96 33 subjects subject NNS cord-354035-i3sl2r0k 96 34 without without IN cord-354035-i3sl2r0k 96 35 respiratory respiratory JJ cord-354035-i3sl2r0k 96 36 symptoms symptom NNS cord-354035-i3sl2r0k 96 37 , , , cord-354035-i3sl2r0k 96 38 and and CC cord-354035-i3sl2r0k 96 39 healthy healthy JJ cord-354035-i3sl2r0k 96 40 volunteers volunteer NNS cord-354035-i3sl2r0k 96 41 . . . cord-354035-i3sl2r0k 97 1 17 17 CD cord-354035-i3sl2r0k 97 2 Anelloviruses Anelloviruses NNPS cord-354035-i3sl2r0k 97 3 , , , cord-354035-i3sl2r0k 97 4 papillomaviruses papillomaviruse NNS cord-354035-i3sl2r0k 97 5 , , , cord-354035-i3sl2r0k 97 6 and and CC cord-354035-i3sl2r0k 97 7 herpesviruses herpesviruses NNP cord-354035-i3sl2r0k 97 8 were be VBD cord-354035-i3sl2r0k 97 9 detected detect VBN cord-354035-i3sl2r0k 97 10 . . . cord-354035-i3sl2r0k 98 1 The the DT cord-354035-i3sl2r0k 98 2 striking striking JJ cord-354035-i3sl2r0k 98 3 observation observation NN cord-354035-i3sl2r0k 98 4 in in IN cord-354035-i3sl2r0k 98 5 this this DT cord-354035-i3sl2r0k 98 6 study study NN cord-354035-i3sl2r0k 98 7 was be VBD cord-354035-i3sl2r0k 98 8 that that IN cord-354035-i3sl2r0k 98 9 the the DT cord-354035-i3sl2r0k 98 10 diversity diversity NN cord-354035-i3sl2r0k 98 11 and and CC cord-354035-i3sl2r0k 98 12 abundance abundance NN cord-354035-i3sl2r0k 98 13 of of IN cord-354035-i3sl2r0k 98 14 anelloviruses anelloviruse NNS cord-354035-i3sl2r0k 98 15 was be VBD cord-354035-i3sl2r0k 98 16 highly highly RB cord-354035-i3sl2r0k 98 17 increased increase VBN cord-354035-i3sl2r0k 98 18 in in IN cord-354035-i3sl2r0k 98 19 the the DT cord-354035-i3sl2r0k 98 20 transplant transplant NN cord-354035-i3sl2r0k 98 21 patients patient NNS cord-354035-i3sl2r0k 98 22 compared compare VBN cord-354035-i3sl2r0k 98 23 with with IN cord-354035-i3sl2r0k 98 24 patients patient NNS cord-354035-i3sl2r0k 98 25 with with IN cord-354035-i3sl2r0k 98 26 HIV HIV NNP cord-354035-i3sl2r0k 98 27 and and CC cord-354035-i3sl2r0k 98 28 healthy healthy JJ cord-354035-i3sl2r0k 98 29 controls control NNS cord-354035-i3sl2r0k 98 30 . . . cord-354035-i3sl2r0k 99 1 This this DT cord-354035-i3sl2r0k 99 2 finding finding NN cord-354035-i3sl2r0k 99 3 was be VBD cord-354035-i3sl2r0k 99 4 true true JJ cord-354035-i3sl2r0k 99 5 in in IN cord-354035-i3sl2r0k 99 6 both both CC cord-354035-i3sl2r0k 99 7 the the DT cord-354035-i3sl2r0k 99 8 lower low JJR cord-354035-i3sl2r0k 99 9 airway airway NN cord-354035-i3sl2r0k 99 10 lavage lavage NN cord-354035-i3sl2r0k 99 11 samples sample NNS cord-354035-i3sl2r0k 99 12 and and CC cord-354035-i3sl2r0k 99 13 the the DT cord-354035-i3sl2r0k 99 14 upper upper JJ cord-354035-i3sl2r0k 99 15 airway airway NN cord-354035-i3sl2r0k 99 16 oral oral JJ cord-354035-i3sl2r0k 99 17 washes wash NNS cord-354035-i3sl2r0k 99 18 . . . cord-354035-i3sl2r0k 100 1 Although although IN cord-354035-i3sl2r0k 100 2 anelloviruses anelloviruse NNS cord-354035-i3sl2r0k 100 3 are be VBP cord-354035-i3sl2r0k 100 4 not not RB cord-354035-i3sl2r0k 100 5 known know VBN cord-354035-i3sl2r0k 100 6 to to TO cord-354035-i3sl2r0k 100 7 be be VB cord-354035-i3sl2r0k 100 8 pathogenic pathogenic JJ cord-354035-i3sl2r0k 100 9 , , , cord-354035-i3sl2r0k 100 10 they -PRON- PRP cord-354035-i3sl2r0k 100 11 seem seem VBP cord-354035-i3sl2r0k 100 12 to to TO cord-354035-i3sl2r0k 100 13 be be VB cord-354035-i3sl2r0k 100 14 a a DT cord-354035-i3sl2r0k 100 15 marker marker NN cord-354035-i3sl2r0k 100 16 of of IN cord-354035-i3sl2r0k 100 17 immunosuppression immunosuppression NN cord-354035-i3sl2r0k 100 18 . . . cord-354035-i3sl2r0k 101 1 18 18 CD cord-354035-i3sl2r0k 102 1 The the DT cord-354035-i3sl2r0k 102 2 effects effect NNS cord-354035-i3sl2r0k 102 3 of of IN cord-354035-i3sl2r0k 102 4 their -PRON- PRP$ cord-354035-i3sl2r0k 102 5 dysregulation dysregulation NN cord-354035-i3sl2r0k 102 6 on on IN cord-354035-i3sl2r0k 102 7 engraftment engraftment NN cord-354035-i3sl2r0k 102 8 or or CC cord-354035-i3sl2r0k 102 9 outcome outcome NN cord-354035-i3sl2r0k 102 10 , , , cord-354035-i3sl2r0k 102 11 if if IN cord-354035-i3sl2r0k 102 12 any any DT cord-354035-i3sl2r0k 102 13 , , , cord-354035-i3sl2r0k 102 14 are be VBP cord-354035-i3sl2r0k 102 15 not not RB cord-354035-i3sl2r0k 102 16 known know VBN cord-354035-i3sl2r0k 102 17 at at IN cord-354035-i3sl2r0k 102 18 this this DT cord-354035-i3sl2r0k 102 19 time time NN cord-354035-i3sl2r0k 102 20 . . . cord-354035-i3sl2r0k 103 1 Since since IN cord-354035-i3sl2r0k 103 2 the the DT cord-354035-i3sl2r0k 103 3 discovery discovery NN cord-354035-i3sl2r0k 103 4 of of IN cord-354035-i3sl2r0k 103 5 severe severe JJ cord-354035-i3sl2r0k 103 6 acute acute JJ cord-354035-i3sl2r0k 103 7 respiratory respiratory JJ cord-354035-i3sl2r0k 103 8 syndrome syndrome NN cord-354035-i3sl2r0k 103 9 coronavirus coronavirus NN cord-354035-i3sl2r0k 103 10 in in IN cord-354035-i3sl2r0k 103 11 2003 2003 CD cord-354035-i3sl2r0k 103 12 , , , cord-354035-i3sl2r0k 103 13 19 19 CD cord-354035-i3sl2r0k 103 14 other other JJ cord-354035-i3sl2r0k 103 15 novel novel JJ cord-354035-i3sl2r0k 103 16 respiratory respiratory JJ cord-354035-i3sl2r0k 103 17 pathogens pathogen NNS cord-354035-i3sl2r0k 103 18 have have VBP cord-354035-i3sl2r0k 103 19 emerged emerge VBN cord-354035-i3sl2r0k 103 20 , , , cord-354035-i3sl2r0k 103 21 including include VBG cord-354035-i3sl2r0k 103 22 coronaviruses coronaviruse NNS cord-354035-i3sl2r0k 103 23 NL63 NL63 NNP cord-354035-i3sl2r0k 103 24 , , , cord-354035-i3sl2r0k 103 25 HKU1 HKU1 NNP cord-354035-i3sl2r0k 103 26 , , , cord-354035-i3sl2r0k 103 27 and and CC cord-354035-i3sl2r0k 103 28 MERS MERS NNP cord-354035-i3sl2r0k 103 29 ( ( -LRB- cord-354035-i3sl2r0k 103 30 reviewed review VBN cord-354035-i3sl2r0k 103 31 in in IN cord-354035-i3sl2r0k 103 32 20 20 CD cord-354035-i3sl2r0k 103 33 ) ) -RRB- cord-354035-i3sl2r0k 103 34 and and CC cord-354035-i3sl2r0k 103 35 influenza influenza NN cord-354035-i3sl2r0k 103 36 viruses virus NNS cord-354035-i3sl2r0k 103 37 H1N1 H1N1 NNP cord-354035-i3sl2r0k 103 38 pandemic pandemic NN cord-354035-i3sl2r0k 103 39 strain strain NN cord-354035-i3sl2r0k 103 40 and and CC cord-354035-i3sl2r0k 103 41 H7N9 H7N9 NNP cord-354035-i3sl2r0k 103 42 . . . cord-354035-i3sl2r0k 104 1 21 21 CD cord-354035-i3sl2r0k 105 1 In in IN cord-354035-i3sl2r0k 105 2 each each DT cord-354035-i3sl2r0k 105 3 case case NN cord-354035-i3sl2r0k 105 4 , , , cord-354035-i3sl2r0k 105 5 the the DT cord-354035-i3sl2r0k 105 6 molecular molecular JJ cord-354035-i3sl2r0k 105 7 tools tool NNS cord-354035-i3sl2r0k 105 8 to to TO cord-354035-i3sl2r0k 105 9 adequately adequately RB cord-354035-i3sl2r0k 105 10 survey survey VB cord-354035-i3sl2r0k 105 11 the the DT cord-354035-i3sl2r0k 105 12 spread spread NN cord-354035-i3sl2r0k 105 13 of of IN cord-354035-i3sl2r0k 105 14 the the DT cord-354035-i3sl2r0k 105 15 virus virus NN cord-354035-i3sl2r0k 105 16 had have VBD cord-354035-i3sl2r0k 105 17 to to TO cord-354035-i3sl2r0k 105 18 be be VB cord-354035-i3sl2r0k 105 19 developed develop VBN cord-354035-i3sl2r0k 105 20 . . . cord-354035-i3sl2r0k 106 1 Once once IN cord-354035-i3sl2r0k 106 2 assays assay NNS cord-354035-i3sl2r0k 106 3 become become VBP cord-354035-i3sl2r0k 106 4 available available JJ cord-354035-i3sl2r0k 106 5 , , , cord-354035-i3sl2r0k 106 6 the the DT cord-354035-i3sl2r0k 106 7 transmission transmission NN cord-354035-i3sl2r0k 106 8 of of IN cord-354035-i3sl2r0k 106 9 these these DT cord-354035-i3sl2r0k 106 10 viruses virus NNS cord-354035-i3sl2r0k 106 11 can can MD cord-354035-i3sl2r0k 106 12 be be VB cord-354035-i3sl2r0k 106 13 tracked track VBN cord-354035-i3sl2r0k 106 14 and and CC cord-354035-i3sl2r0k 106 15 recommendations recommendation NNS cord-354035-i3sl2r0k 106 16 for for IN cord-354035-i3sl2r0k 106 17 protecting protect VBG cord-354035-i3sl2r0k 106 18 public public JJ cord-354035-i3sl2r0k 106 19 health health NN cord-354035-i3sl2r0k 106 20 can can MD cord-354035-i3sl2r0k 106 21 be be VB cord-354035-i3sl2r0k 106 22 made make VBN cord-354035-i3sl2r0k 106 23 . . . cord-354035-i3sl2r0k 107 1 HTS HTS NNP cord-354035-i3sl2r0k 107 2 assays assay NNS cord-354035-i3sl2r0k 107 3 can can MD cord-354035-i3sl2r0k 107 4 be be VB cord-354035-i3sl2r0k 107 5 useful useful JJ cord-354035-i3sl2r0k 107 6 to to TO cord-354035-i3sl2r0k 107 7 survey survey VB cord-354035-i3sl2r0k 107 8 outbreaks outbreak NNS cord-354035-i3sl2r0k 107 9 of of IN cord-354035-i3sl2r0k 107 10 emerging emerge VBG cord-354035-i3sl2r0k 107 11 viruses virus NNS cord-354035-i3sl2r0k 107 12 . . . cord-354035-i3sl2r0k 108 1 A a DT cord-354035-i3sl2r0k 108 2 recent recent JJ cord-354035-i3sl2r0k 108 3 example example NN cord-354035-i3sl2r0k 108 4 of of IN cord-354035-i3sl2r0k 108 5 this this DT cord-354035-i3sl2r0k 108 6 occurred occur VBD cord-354035-i3sl2r0k 108 7 in in IN cord-354035-i3sl2r0k 108 8 the the DT cord-354035-i3sl2r0k 108 9 fall fall NN cord-354035-i3sl2r0k 108 10 of of IN cord-354035-i3sl2r0k 108 11 2014 2014 CD cord-354035-i3sl2r0k 108 12 , , , cord-354035-i3sl2r0k 108 13 when when WRB cord-354035-i3sl2r0k 108 14 the the DT cord-354035-i3sl2r0k 108 15 United United NNP cord-354035-i3sl2r0k 108 16 States States NNP cord-354035-i3sl2r0k 108 17 experienced experience VBD cord-354035-i3sl2r0k 108 18 a a DT cord-354035-i3sl2r0k 108 19 widespread widespread JJ cord-354035-i3sl2r0k 108 20 outbreak outbreak NN cord-354035-i3sl2r0k 108 21 of of IN cord-354035-i3sl2r0k 108 22 enterovirus enterovirus NN cord-354035-i3sl2r0k 108 23 D68 D68 NNP cord-354035-i3sl2r0k 108 24 in in IN cord-354035-i3sl2r0k 108 25 49 49 CD cord-354035-i3sl2r0k 108 26 states state NNS cord-354035-i3sl2r0k 108 27 and and CC cord-354035-i3sl2r0k 108 28 the the DT cord-354035-i3sl2r0k 108 29 District District NNP cord-354035-i3sl2r0k 108 30 of of IN cord-354035-i3sl2r0k 108 31 Columbia Columbia NNP cord-354035-i3sl2r0k 108 32 . . . cord-354035-i3sl2r0k 109 1 This this DT cord-354035-i3sl2r0k 109 2 virus virus NN cord-354035-i3sl2r0k 109 3 had have VBD cord-354035-i3sl2r0k 109 4 previously previously RB cord-354035-i3sl2r0k 109 5 been be VBN cord-354035-i3sl2r0k 109 6 observed observe VBN cord-354035-i3sl2r0k 109 7 rarely rarely RB cord-354035-i3sl2r0k 109 8 . . . cord-354035-i3sl2r0k 110 1 In in IN cord-354035-i3sl2r0k 110 2 multiplex multiplex JJ cord-354035-i3sl2r0k 110 3 PCR pcr NN cord-354035-i3sl2r0k 110 4 panels panel NNS cord-354035-i3sl2r0k 110 5 , , , cord-354035-i3sl2r0k 110 6 the the DT cord-354035-i3sl2r0k 110 7 virus virus NN cord-354035-i3sl2r0k 110 8 was be VBD cord-354035-i3sl2r0k 110 9 either either CC cord-354035-i3sl2r0k 110 10 undetected undetected JJ cord-354035-i3sl2r0k 110 11 or or CC cord-354035-i3sl2r0k 110 12 broadly broadly RB cord-354035-i3sl2r0k 110 13 typed type VBN cord-354035-i3sl2r0k 110 14 only only RB cord-354035-i3sl2r0k 110 15 as as IN cord-354035-i3sl2r0k 110 16 an an DT cord-354035-i3sl2r0k 110 17 enterovirus enterovirus NN cord-354035-i3sl2r0k 110 18 / / SYM cord-354035-i3sl2r0k 110 19 rhinovirus rhinovirus NN cord-354035-i3sl2r0k 110 20 , , , cord-354035-i3sl2r0k 110 21 which which WDT cord-354035-i3sl2r0k 110 22 limited limit VBD cord-354035-i3sl2r0k 110 23 the the DT cord-354035-i3sl2r0k 110 24 study study NN cord-354035-i3sl2r0k 110 25 of of IN cord-354035-i3sl2r0k 110 26 the the DT cord-354035-i3sl2r0k 110 27 outbreak outbreak NN cord-354035-i3sl2r0k 110 28 . . . cord-354035-i3sl2r0k 111 1 Typing type VBG cord-354035-i3sl2r0k 111 2 of of IN cord-354035-i3sl2r0k 111 3 the the DT cord-354035-i3sl2r0k 111 4 virus virus NN cord-354035-i3sl2r0k 111 5 initially initially RB cord-354035-i3sl2r0k 111 6 involved involve VBD cord-354035-i3sl2r0k 111 7 a a DT cord-354035-i3sl2r0k 111 8 labor labor NN cord-354035-i3sl2r0k 111 9 - - HYPH cord-354035-i3sl2r0k 111 10 intensive intensive JJ cord-354035-i3sl2r0k 111 11 and and CC cord-354035-i3sl2r0k 111 12 slow slow JJ cord-354035-i3sl2r0k 111 13 method method NN cord-354035-i3sl2r0k 111 14 in in IN cord-354035-i3sl2r0k 111 15 which which WDT cord-354035-i3sl2r0k 111 16 an an DT cord-354035-i3sl2r0k 111 17 amplicon amplicon NN cord-354035-i3sl2r0k 111 18 was be VBD cord-354035-i3sl2r0k 111 19 generated generate VBN cord-354035-i3sl2r0k 111 20 and and CC cord-354035-i3sl2r0k 111 21 sequenced sequence VBN cord-354035-i3sl2r0k 111 22 , , , cord-354035-i3sl2r0k 111 23 and and CC cord-354035-i3sl2r0k 111 24 the the DT cord-354035-i3sl2r0k 111 25 sequence sequence NN cord-354035-i3sl2r0k 111 26 was be VBD cord-354035-i3sl2r0k 111 27 compared compare VBN cord-354035-i3sl2r0k 111 28 with with IN cord-354035-i3sl2r0k 111 29 reference reference NN cord-354035-i3sl2r0k 111 30 strains strain NNS cord-354035-i3sl2r0k 111 31 for for IN cord-354035-i3sl2r0k 111 32 typing typing NN cord-354035-i3sl2r0k 111 33 . . . cord-354035-i3sl2r0k 112 1 The the DT cord-354035-i3sl2r0k 112 2 genomes genome NNS cord-354035-i3sl2r0k 112 3 of of IN cord-354035-i3sl2r0k 112 4 the the DT cord-354035-i3sl2r0k 112 5 outbreak outbreak NN cord-354035-i3sl2r0k 112 6 strains strain NNS cord-354035-i3sl2r0k 112 7 were be VBD cord-354035-i3sl2r0k 112 8 sequenced sequence VBN cord-354035-i3sl2r0k 112 9 22 22 CD cord-354035-i3sl2r0k 112 10 ( ( -LRB- cord-354035-i3sl2r0k 112 11 and and CC cord-354035-i3sl2r0k 112 12 also also RB cord-354035-i3sl2r0k 112 13 by by IN cord-354035-i3sl2r0k 112 14 the the DT cord-354035-i3sl2r0k 112 15 Centers Centers NNPS cord-354035-i3sl2r0k 112 16 for for IN cord-354035-i3sl2r0k 112 17 Disease Disease NNP cord-354035-i3sl2r0k 112 18 Control Control NNP cord-354035-i3sl2r0k 112 19 and and CC cord-354035-i3sl2r0k 112 20 Prevention Prevention NNP cord-354035-i3sl2r0k 112 21 ) ) -RRB- cord-354035-i3sl2r0k 112 22 , , , cord-354035-i3sl2r0k 112 23 and and CC cord-354035-i3sl2r0k 112 24 subsequently subsequently RB cord-354035-i3sl2r0k 112 25 a a DT cord-354035-i3sl2r0k 112 26 highly highly RB cord-354035-i3sl2r0k 112 27 specific specific JJ cord-354035-i3sl2r0k 112 28 molecular molecular JJ cord-354035-i3sl2r0k 112 29 assay assay NN cord-354035-i3sl2r0k 112 30 was be VBD cord-354035-i3sl2r0k 112 31 developed develop VBN cord-354035-i3sl2r0k 112 32 in in IN cord-354035-i3sl2r0k 112 33 order order NN cord-354035-i3sl2r0k 112 34 to to TO cord-354035-i3sl2r0k 112 35 aid aid VB cord-354035-i3sl2r0k 112 36 in in IN cord-354035-i3sl2r0k 112 37 detection detection NN cord-354035-i3sl2r0k 112 38 and and CC cord-354035-i3sl2r0k 112 39 typing typing NN cord-354035-i3sl2r0k 112 40 of of IN cord-354035-i3sl2r0k 112 41 the the DT cord-354035-i3sl2r0k 112 42 outbreak outbreak NN cord-354035-i3sl2r0k 112 43 strain strain NN cord-354035-i3sl2r0k 112 44 . . . cord-354035-i3sl2r0k 113 1 23 23 CD cord-354035-i3sl2r0k 114 1 In in IN cord-354035-i3sl2r0k 114 2 this this DT cord-354035-i3sl2r0k 114 3 case case NN cord-354035-i3sl2r0k 114 4 , , , cord-354035-i3sl2r0k 114 5 sequencing sequencing NN cord-354035-i3sl2r0k 114 6 provided provide VBN cord-354035-i3sl2r0k 114 7 specific specific JJ cord-354035-i3sl2r0k 114 8 viral viral JJ cord-354035-i3sl2r0k 114 9 typing typing NN cord-354035-i3sl2r0k 114 10 and and CC cord-354035-i3sl2r0k 114 11 allowed allow VBN cord-354035-i3sl2r0k 114 12 for for IN cord-354035-i3sl2r0k 114 13 genomic genomic JJ cord-354035-i3sl2r0k 114 14 characterization characterization NN cord-354035-i3sl2r0k 114 15 and and CC cord-354035-i3sl2r0k 114 16 design design NN cord-354035-i3sl2r0k 114 17 of of IN cord-354035-i3sl2r0k 114 18 a a DT cord-354035-i3sl2r0k 114 19 specific specific JJ cord-354035-i3sl2r0k 114 20 laboratory laboratory NN cord-354035-i3sl2r0k 114 21 developed develop VBN cord-354035-i3sl2r0k 114 22 test test NN cord-354035-i3sl2r0k 114 23 . . . cord-354035-i3sl2r0k 115 1 This this DT cord-354035-i3sl2r0k 115 2 model model NN cord-354035-i3sl2r0k 115 3 could could MD cord-354035-i3sl2r0k 115 4 be be VB cord-354035-i3sl2r0k 115 5 useful useful JJ cord-354035-i3sl2r0k 115 6 for for IN cord-354035-i3sl2r0k 115 7 future future JJ cord-354035-i3sl2r0k 115 8 outbreaks outbreak NNS cord-354035-i3sl2r0k 115 9 . . . cord-354035-i3sl2r0k 116 1 The the DT cord-354035-i3sl2r0k 116 2 workhorses workhorse NNS cord-354035-i3sl2r0k 116 3 for for IN cord-354035-i3sl2r0k 116 4 clinical clinical JJ cord-354035-i3sl2r0k 116 5 testing testing NN cord-354035-i3sl2r0k 116 6 of of IN cord-354035-i3sl2r0k 116 7 respiratory respiratory JJ cord-354035-i3sl2r0k 116 8 viruses virus NNS cord-354035-i3sl2r0k 116 9 are be VBP cord-354035-i3sl2r0k 116 10 multiplex multiplex JJ cord-354035-i3sl2r0k 116 11 PCR pcr NN cord-354035-i3sl2r0k 116 12 panels panel NNS cord-354035-i3sl2r0k 116 13 that that WDT cord-354035-i3sl2r0k 116 14 target target VBP cord-354035-i3sl2r0k 116 15 the the DT cord-354035-i3sl2r0k 116 16 most most RBS cord-354035-i3sl2r0k 116 17 common common JJ cord-354035-i3sl2r0k 116 18 respiratory respiratory JJ cord-354035-i3sl2r0k 116 19 viruses virus NNS cord-354035-i3sl2r0k 116 20 . . . cord-354035-i3sl2r0k 117 1 These these DT cord-354035-i3sl2r0k 117 2 assays assay NNS cord-354035-i3sl2r0k 117 3 are be VBP cord-354035-i3sl2r0k 117 4 highly highly RB cord-354035-i3sl2r0k 117 5 sensitive sensitive JJ cord-354035-i3sl2r0k 117 6 and and CC cord-354035-i3sl2r0k 117 7 yield yield VBP cord-354035-i3sl2r0k 117 8 rapid rapid JJ cord-354035-i3sl2r0k 117 9 results result NNS cord-354035-i3sl2r0k 117 10 . . . cord-354035-i3sl2r0k 118 1 However however RB cord-354035-i3sl2r0k 118 2 , , , cord-354035-i3sl2r0k 118 3 PCR PCR NNP cord-354035-i3sl2r0k 118 4 - - HYPH cord-354035-i3sl2r0k 118 5 based base VBN cord-354035-i3sl2r0k 118 6 assays assay NNS cord-354035-i3sl2r0k 118 7 can can MD cord-354035-i3sl2r0k 118 8 have have VB cord-354035-i3sl2r0k 118 9 limitations limitation NNS cord-354035-i3sl2r0k 118 10 . . . cord-354035-i3sl2r0k 119 1 In in IN cord-354035-i3sl2r0k 119 2 most most JJS cord-354035-i3sl2r0k 119 3 multiplex multiplex JJ cord-354035-i3sl2r0k 119 4 panels panel NNS cord-354035-i3sl2r0k 119 5 , , , cord-354035-i3sl2r0k 119 6 the the DT cord-354035-i3sl2r0k 119 7 assays assay NNS cord-354035-i3sl2r0k 119 8 can can MD cord-354035-i3sl2r0k 119 9 not not RB cord-354035-i3sl2r0k 119 10 be be VB cord-354035-i3sl2r0k 119 11 used use VBN cord-354035-i3sl2r0k 119 12 to to IN cord-354035-i3sl2r0k 119 13 subtype subtype NN cord-354035-i3sl2r0k 119 14 viruses virus NNS cord-354035-i3sl2r0k 119 15 , , , cord-354035-i3sl2r0k 119 16 identify identify VB cord-354035-i3sl2r0k 119 17 drug drug NN cord-354035-i3sl2r0k 119 18 - - HYPH cord-354035-i3sl2r0k 119 19 resistant resistant JJ cord-354035-i3sl2r0k 119 20 alleles allele NNS cord-354035-i3sl2r0k 119 21 , , , cord-354035-i3sl2r0k 119 22 or or CC cord-354035-i3sl2r0k 119 23 identify identify VB cord-354035-i3sl2r0k 119 24 viruses virus NNS cord-354035-i3sl2r0k 119 25 not not RB cord-354035-i3sl2r0k 119 26 targeted target VBN cord-354035-i3sl2r0k 119 27 by by IN cord-354035-i3sl2r0k 119 28 the the DT cord-354035-i3sl2r0k 119 29 panel panel NN cord-354035-i3sl2r0k 119 30 . . . cord-354035-i3sl2r0k 120 1 Evolving evolve VBG cord-354035-i3sl2r0k 120 2 viruses virus NNS cord-354035-i3sl2r0k 120 3 may may MD cord-354035-i3sl2r0k 120 4 also also RB cord-354035-i3sl2r0k 120 5 mutate mutate VB cord-354035-i3sl2r0k 120 6 in in IN cord-354035-i3sl2r0k 120 7 the the DT cord-354035-i3sl2r0k 120 8 region region NN cord-354035-i3sl2r0k 120 9 targeted target VBN cord-354035-i3sl2r0k 120 10 by by IN cord-354035-i3sl2r0k 120 11 the the DT cord-354035-i3sl2r0k 120 12 PCR PCR NNP cord-354035-i3sl2r0k 120 13 primers primer NNS cord-354035-i3sl2r0k 120 14 and and CC cord-354035-i3sl2r0k 120 15 be be VB cord-354035-i3sl2r0k 120 16 missed miss VBN cord-354035-i3sl2r0k 120 17 by by IN cord-354035-i3sl2r0k 120 18 the the DT cord-354035-i3sl2r0k 120 19 assay assay NN cord-354035-i3sl2r0k 120 20 . . . cord-354035-i3sl2r0k 121 1 For for IN cord-354035-i3sl2r0k 121 2 these these DT cord-354035-i3sl2r0k 121 3 reasons reason NNS cord-354035-i3sl2r0k 121 4 , , , cord-354035-i3sl2r0k 121 5 HTS HTS NNP cord-354035-i3sl2r0k 121 6 - - HYPH cord-354035-i3sl2r0k 121 7 based base VBN cord-354035-i3sl2r0k 121 8 assays assay NNS cord-354035-i3sl2r0k 121 9 could could MD cord-354035-i3sl2r0k 121 10 have have VB cord-354035-i3sl2r0k 121 11 a a DT cord-354035-i3sl2r0k 121 12 role role NN cord-354035-i3sl2r0k 121 13 in in IN cord-354035-i3sl2r0k 121 14 the the DT cord-354035-i3sl2r0k 121 15 clinic clinic NN cord-354035-i3sl2r0k 121 16 . . . cord-354035-i3sl2r0k 122 1 Recently recently RB cord-354035-i3sl2r0k 122 2 , , , cord-354035-i3sl2r0k 122 3 several several JJ cord-354035-i3sl2r0k 122 4 groups group NNS cord-354035-i3sl2r0k 122 5 have have VBP cord-354035-i3sl2r0k 122 6 compared compare VBN cord-354035-i3sl2r0k 122 7 the the DT cord-354035-i3sl2r0k 122 8 results result NNS cord-354035-i3sl2r0k 122 9 from from IN cord-354035-i3sl2r0k 122 10 HTS HTS NNP cord-354035-i3sl2r0k 122 11 with with IN cord-354035-i3sl2r0k 122 12 standard standard JJ cord-354035-i3sl2r0k 122 13 clinical clinical JJ cord-354035-i3sl2r0k 122 14 assays assay NNS cord-354035-i3sl2r0k 122 15 for for IN cord-354035-i3sl2r0k 122 16 detection detection NN cord-354035-i3sl2r0k 122 17 of of IN cord-354035-i3sl2r0k 122 18 viruses virus NNS cord-354035-i3sl2r0k 122 19 in in IN cord-354035-i3sl2r0k 122 20 the the DT cord-354035-i3sl2r0k 122 21 respiratory respiratory JJ cord-354035-i3sl2r0k 122 22 tract tract NN cord-354035-i3sl2r0k 122 23 . . . cord-354035-i3sl2r0k 123 1 One one CD cord-354035-i3sl2r0k 123 2 study study NN cord-354035-i3sl2r0k 123 3 found find VBD cord-354035-i3sl2r0k 123 4 that that IN cord-354035-i3sl2r0k 123 5 RNA RNA NNP cord-354035-i3sl2r0k 123 6 sequencing sequencing NN cord-354035-i3sl2r0k 123 7 and and CC cord-354035-i3sl2r0k 123 8 the the DT cord-354035-i3sl2r0k 123 9 Gen Gen NNP cord-354035-i3sl2r0k 123 10 - - HYPH cord-354035-i3sl2r0k 123 11 Mark Mark NNP cord-354035-i3sl2r0k 123 12 eSensor eSensor NNP cord-354035-i3sl2r0k 123 13 Respiratory Respiratory NNP cord-354035-i3sl2r0k 123 14 Virus Virus NNP cord-354035-i3sl2r0k 123 15 Panel Panel NNP cord-354035-i3sl2r0k 123 16 ( ( -LRB- cord-354035-i3sl2r0k 123 17 RVP RVP NNP cord-354035-i3sl2r0k 123 18 ) ) -RRB- cord-354035-i3sl2r0k 123 19 had have VBD cord-354035-i3sl2r0k 123 20 an an DT cord-354035-i3sl2r0k 123 21 86 86 CD cord-354035-i3sl2r0k 123 22 % % NN cord-354035-i3sl2r0k 123 23 correlation correlation NN cord-354035-i3sl2r0k 123 24 rate rate NN cord-354035-i3sl2r0k 123 25 on on IN cord-354035-i3sl2r0k 123 26 one one CD cord-354035-i3sl2r0k 123 27 set set NN cord-354035-i3sl2r0k 123 28 of of IN cord-354035-i3sl2r0k 123 29 42 42 CD cord-354035-i3sl2r0k 123 30 known know VBN cord-354035-i3sl2r0k 123 31 positive positive JJ cord-354035-i3sl2r0k 123 32 nasopharyngeal nasopharyngeal JJ cord-354035-i3sl2r0k 123 33 swab swab NN cord-354035-i3sl2r0k 123 34 samples sample NNS cord-354035-i3sl2r0k 123 35 and and CC cord-354035-i3sl2r0k 123 36 93 93 CD cord-354035-i3sl2r0k 123 37 % % NN cord-354035-i3sl2r0k 123 38 correlation correlation NN cord-354035-i3sl2r0k 123 39 on on IN cord-354035-i3sl2r0k 123 40 a a DT cord-354035-i3sl2r0k 123 41 second second JJ cord-354035-i3sl2r0k 123 42 set set NN cord-354035-i3sl2r0k 123 43 of of IN cord-354035-i3sl2r0k 123 44 67 67 CD cord-354035-i3sl2r0k 123 45 samples sample NNS cord-354035-i3sl2r0k 123 46 . . . cord-354035-i3sl2r0k 124 1 24 24 CD cord-354035-i3sl2r0k 124 2 High high JJ cord-354035-i3sl2r0k 124 3 - - HYPH cord-354035-i3sl2r0k 124 4 throughput throughput NN cord-354035-i3sl2r0k 124 5 RNA rna NN cord-354035-i3sl2r0k 124 6 sequencing sequencing NN cord-354035-i3sl2r0k 124 7 detected detect VBD cord-354035-i3sl2r0k 124 8 12 12 CD cord-354035-i3sl2r0k 124 9 viruses virus NNS cord-354035-i3sl2r0k 124 10 that that WDT cord-354035-i3sl2r0k 124 11 were be VBD cord-354035-i3sl2r0k 124 12 either either CC cord-354035-i3sl2r0k 124 13 not not RB cord-354035-i3sl2r0k 124 14 included include VBN cord-354035-i3sl2r0k 124 15 in in IN cord-354035-i3sl2r0k 124 16 the the DT cord-354035-i3sl2r0k 124 17 RVP RVP NNP cord-354035-i3sl2r0k 124 18 panel panel NN cord-354035-i3sl2r0k 124 19 or or CC cord-354035-i3sl2r0k 124 20 whose whose WP$ cord-354035-i3sl2r0k 124 21 sequence sequence NN cord-354035-i3sl2r0k 124 22 was be VBD cord-354035-i3sl2r0k 124 23 divergent divergent JJ cord-354035-i3sl2r0k 124 24 from from IN cord-354035-i3sl2r0k 124 25 the the DT cord-354035-i3sl2r0k 124 26 RVP RVP NNP cord-354035-i3sl2r0k 124 27 target target NN cord-354035-i3sl2r0k 124 28 and and CC cord-354035-i3sl2r0k 124 29 , , , cord-354035-i3sl2r0k 124 30 thus thus RB cord-354035-i3sl2r0k 124 31 , , , cord-354035-i3sl2r0k 124 32 not not RB cord-354035-i3sl2r0k 124 33 detected detect VBN cord-354035-i3sl2r0k 124 34 . . . cord-354035-i3sl2r0k 125 1 Furthermore furthermore RB cord-354035-i3sl2r0k 125 2 , , , cord-354035-i3sl2r0k 125 3 viral viral JJ cord-354035-i3sl2r0k 125 4 subtypes subtype NNS cord-354035-i3sl2r0k 125 5 were be VBD cord-354035-i3sl2r0k 125 6 determined determine VBN cord-354035-i3sl2r0k 125 7 for for IN cord-354035-i3sl2r0k 125 8 influenza influenza NN cord-354035-i3sl2r0k 125 9 A a NN cord-354035-i3sl2r0k 125 10 ( ( -LRB- cord-354035-i3sl2r0k 125 11 as as RB cord-354035-i3sl2r0k 125 12 well well RB cord-354035-i3sl2r0k 125 13 as as IN cord-354035-i3sl2r0k 125 14 identification identification NN cord-354035-i3sl2r0k 125 15 of of IN cord-354035-i3sl2r0k 125 16 the the DT cord-354035-i3sl2r0k 125 17 oseltamivir oseltamivir NNP cord-354035-i3sl2r0k 125 18 resistance resistance NN cord-354035-i3sl2r0k 125 19 mutation mutation NN cord-354035-i3sl2r0k 125 20 ) ) -RRB- cord-354035-i3sl2r0k 125 21 , , , cord-354035-i3sl2r0k 125 22 respiratory respiratory JJ cord-354035-i3sl2r0k 125 23 syncytial syncytial JJ cord-354035-i3sl2r0k 125 24 viruses virus NNS cord-354035-i3sl2r0k 125 25 , , , cord-354035-i3sl2r0k 125 26 and and CC cord-354035-i3sl2r0k 125 27 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 125 28 . . . cord-354035-i3sl2r0k 126 1 Another another DT cord-354035-i3sl2r0k 126 2 study study NN cord-354035-i3sl2r0k 126 3 tested test VBD cord-354035-i3sl2r0k 126 4 89 89 CD cord-354035-i3sl2r0k 126 5 nasopharyngeal nasopharyngeal JJ cord-354035-i3sl2r0k 126 6 swabs swab NNS cord-354035-i3sl2r0k 126 7 from from IN cord-354035-i3sl2r0k 126 8 adults adult NNS cord-354035-i3sl2r0k 126 9 with with IN cord-354035-i3sl2r0k 126 10 upper upper JJ cord-354035-i3sl2r0k 126 11 respiratory respiratory JJ cord-354035-i3sl2r0k 126 12 tract tract NN cord-354035-i3sl2r0k 126 13 infections infection NNS cord-354035-i3sl2r0k 126 14 using use VBG cord-354035-i3sl2r0k 126 15 reverse reverse JJ cord-354035-i3sl2r0k 126 16 transcription transcription NN cord-354035-i3sl2r0k 126 17 ( ( -LRB- cord-354035-i3sl2r0k 126 18 RT)-PCR rt)-pcr NN cord-354035-i3sl2r0k 126 19 assays assay NNS cord-354035-i3sl2r0k 126 20 for for IN cord-354035-i3sl2r0k 126 21 a a DT cord-354035-i3sl2r0k 126 22 series series NN cord-354035-i3sl2r0k 126 23 of of IN cord-354035-i3sl2r0k 126 24 common common JJ cord-354035-i3sl2r0k 126 25 viruses virus NNS cord-354035-i3sl2r0k 126 26 , , , cord-354035-i3sl2r0k 126 27 including include VBG cord-354035-i3sl2r0k 126 28 human human JJ cord-354035-i3sl2r0k 126 29 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 126 30 , , , cord-354035-i3sl2r0k 126 31 coronaviruses coronaviruse NNS cord-354035-i3sl2r0k 126 32 , , , cord-354035-i3sl2r0k 126 33 influenza influenza NN cord-354035-i3sl2r0k 126 34 viruses virus NNS cord-354035-i3sl2r0k 126 35 and and CC cord-354035-i3sl2r0k 126 36 others other NNS cord-354035-i3sl2r0k 126 37 , , , cord-354035-i3sl2r0k 126 38 and and CC cord-354035-i3sl2r0k 126 39 by by IN cord-354035-i3sl2r0k 126 40 RNA RNA NNP cord-354035-i3sl2r0k 126 41 sequencing sequencing NN cord-354035-i3sl2r0k 126 42 . . . cord-354035-i3sl2r0k 127 1 25 25 CD cord-354035-i3sl2r0k 128 1 The the DT cord-354035-i3sl2r0k 128 2 HTS HTS NNP cord-354035-i3sl2r0k 128 3 assay assay NN cord-354035-i3sl2r0k 128 4 had have VBD cord-354035-i3sl2r0k 128 5 a a DT cord-354035-i3sl2r0k 128 6 sensitivity sensitivity NN cord-354035-i3sl2r0k 128 7 of of IN cord-354035-i3sl2r0k 128 8 77 77 CD cord-354035-i3sl2r0k 128 9 % % NN cord-354035-i3sl2r0k 128 10 compared compare VBN cord-354035-i3sl2r0k 128 11 with with IN cord-354035-i3sl2r0k 128 12 the the DT cord-354035-i3sl2r0k 128 13 PCR PCR NNP cord-354035-i3sl2r0k 128 14 assays assay NNS cord-354035-i3sl2r0k 128 15 . . . cord-354035-i3sl2r0k 129 1 The the DT cord-354035-i3sl2r0k 129 2 viruses virus NNS cord-354035-i3sl2r0k 129 3 that that WDT cord-354035-i3sl2r0k 129 4 were be VBD cord-354035-i3sl2r0k 129 5 not not RB cord-354035-i3sl2r0k 129 6 detected detect VBN cord-354035-i3sl2r0k 129 7 by by IN cord-354035-i3sl2r0k 129 8 HTS HTS NNP cord-354035-i3sl2r0k 129 9 had have VBD cord-354035-i3sl2r0k 129 10 higher high JJR cord-354035-i3sl2r0k 129 11 cycle cycle NN cord-354035-i3sl2r0k 129 12 threshold threshold NN cord-354035-i3sl2r0k 129 13 ( ( -LRB- cord-354035-i3sl2r0k 129 14 Ct Ct NNP cord-354035-i3sl2r0k 129 15 ) ) -RRB- cord-354035-i3sl2r0k 129 16 values value NNS cord-354035-i3sl2r0k 129 17 in in IN cord-354035-i3sl2r0k 129 18 the the DT cord-354035-i3sl2r0k 129 19 real real JJ cord-354035-i3sl2r0k 129 20 - - HYPH cord-354035-i3sl2r0k 129 21 time time NN cord-354035-i3sl2r0k 129 22 RT RT NNP cord-354035-i3sl2r0k 129 23 - - HYPH cord-354035-i3sl2r0k 129 24 PCR PCR NNP cord-354035-i3sl2r0k 129 25 assays assay NNS cord-354035-i3sl2r0k 129 26 , , , cord-354035-i3sl2r0k 129 27 indicating indicate VBG cord-354035-i3sl2r0k 129 28 there there EX cord-354035-i3sl2r0k 129 29 were be VBD cord-354035-i3sl2r0k 129 30 lower low JJR cord-354035-i3sl2r0k 129 31 levels level NNS cord-354035-i3sl2r0k 129 32 of of IN cord-354035-i3sl2r0k 129 33 viral viral JJ cord-354035-i3sl2r0k 129 34 nucleic nucleic JJ cord-354035-i3sl2r0k 129 35 acid acid NN cord-354035-i3sl2r0k 129 36 present present JJ cord-354035-i3sl2r0k 129 37 in in IN cord-354035-i3sl2r0k 129 38 those those DT cord-354035-i3sl2r0k 129 39 samples sample NNS cord-354035-i3sl2r0k 129 40 . . . cord-354035-i3sl2r0k 130 1 Again again RB cord-354035-i3sl2r0k 130 2 , , , cord-354035-i3sl2r0k 130 3 HTS HTS NNP cord-354035-i3sl2r0k 130 4 had have VBD cord-354035-i3sl2r0k 130 5 the the DT cord-354035-i3sl2r0k 130 6 advantage advantage NN cord-354035-i3sl2r0k 130 7 of of IN cord-354035-i3sl2r0k 130 8 providing provide VBG cord-354035-i3sl2r0k 130 9 additional additional JJ cord-354035-i3sl2r0k 130 10 subtyping subtyping NN cord-354035-i3sl2r0k 130 11 information information NN cord-354035-i3sl2r0k 130 12 , , , cord-354035-i3sl2r0k 130 13 in in IN cord-354035-i3sl2r0k 130 14 this this DT cord-354035-i3sl2r0k 130 15 case case NN cord-354035-i3sl2r0k 130 16 for for IN cord-354035-i3sl2r0k 130 17 human human JJ cord-354035-i3sl2r0k 130 18 enteroviruses enterovirus NNS cord-354035-i3sl2r0k 130 19 , , , cord-354035-i3sl2r0k 130 20 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 130 21 , , , cord-354035-i3sl2r0k 130 22 metapneumovirus metapneumovirus NNP cord-354035-i3sl2r0k 130 23 , , , cord-354035-i3sl2r0k 130 24 and and CC cord-354035-i3sl2r0k 130 25 respiratory respiratory JJ cord-354035-i3sl2r0k 130 26 syncytial syncytial JJ cord-354035-i3sl2r0k 130 27 virus virus NN cord-354035-i3sl2r0k 130 28 . . . cord-354035-i3sl2r0k 131 1 A a DT cord-354035-i3sl2r0k 131 2 third third JJ cord-354035-i3sl2r0k 131 3 study study NN cord-354035-i3sl2r0k 131 4 demonstrated demonstrate VBD cord-354035-i3sl2r0k 131 5 that that IN cord-354035-i3sl2r0k 131 6 HTS HTS NNP cord-354035-i3sl2r0k 131 7 could could MD cord-354035-i3sl2r0k 131 8 be be VB cord-354035-i3sl2r0k 131 9 used use VBN cord-354035-i3sl2r0k 131 10 to to TO cord-354035-i3sl2r0k 131 11 detect detect VB cord-354035-i3sl2r0k 131 12 a a DT cord-354035-i3sl2r0k 131 13 pathogen pathogen NN cord-354035-i3sl2r0k 131 14 ( ( -LRB- cord-354035-i3sl2r0k 131 15 rhinovirus rhinovirus NN cord-354035-i3sl2r0k 131 16 C C NNP cord-354035-i3sl2r0k 131 17 ) ) -RRB- cord-354035-i3sl2r0k 131 18 in in IN cord-354035-i3sl2r0k 131 19 a a DT cord-354035-i3sl2r0k 131 20 sample sample NN cord-354035-i3sl2r0k 131 21 from from IN cord-354035-i3sl2r0k 131 22 a a DT cord-354035-i3sl2r0k 131 23 child child NN cord-354035-i3sl2r0k 131 24 with with IN cord-354035-i3sl2r0k 131 25 respiratory respiratory JJ cord-354035-i3sl2r0k 131 26 symptoms symptom NNS cord-354035-i3sl2r0k 131 27 in in IN cord-354035-i3sl2r0k 131 28 which which WDT cord-354035-i3sl2r0k 131 29 no no DT cord-354035-i3sl2r0k 131 30 virus virus NN cord-354035-i3sl2r0k 131 31 had have VBD cord-354035-i3sl2r0k 131 32 been be VBN cord-354035-i3sl2r0k 131 33 detected detect VBN cord-354035-i3sl2r0k 131 34 by by IN cord-354035-i3sl2r0k 131 35 PCR PCR NNP cord-354035-i3sl2r0k 131 36 . . . cord-354035-i3sl2r0k 132 1 26 26 CD cord-354035-i3sl2r0k 132 2 Taken take VBN cord-354035-i3sl2r0k 132 3 together together RB cord-354035-i3sl2r0k 132 4 , , , cord-354035-i3sl2r0k 132 5 these these DT cord-354035-i3sl2r0k 132 6 data datum NNS cord-354035-i3sl2r0k 132 7 show show VBP cord-354035-i3sl2r0k 132 8 that that IN cord-354035-i3sl2r0k 132 9 in in IN cord-354035-i3sl2r0k 132 10 some some DT cord-354035-i3sl2r0k 132 11 cases case NNS cord-354035-i3sl2r0k 132 12 HTS HTS NNP cord-354035-i3sl2r0k 132 13 could could MD cord-354035-i3sl2r0k 132 14 be be VB cord-354035-i3sl2r0k 132 15 advantageous advantageous JJ cord-354035-i3sl2r0k 132 16 compared compare VBN cord-354035-i3sl2r0k 132 17 with with IN cord-354035-i3sl2r0k 132 18 PCR PCR NNP cord-354035-i3sl2r0k 132 19 assays assay NNS cord-354035-i3sl2r0k 132 20 , , , cord-354035-i3sl2r0k 132 21 but but CC cord-354035-i3sl2r0k 132 22 sensitivity sensitivity NN cord-354035-i3sl2r0k 132 23 of of IN cord-354035-i3sl2r0k 132 24 sequencing sequencing NN cord-354035-i3sl2r0k 132 25 can can MD cord-354035-i3sl2r0k 132 26 be be VB cord-354035-i3sl2r0k 132 27 a a DT cord-354035-i3sl2r0k 132 28 limitation limitation NN cord-354035-i3sl2r0k 132 29 . . . cord-354035-i3sl2r0k 133 1 The the DT cord-354035-i3sl2r0k 133 2 studies study NNS cord-354035-i3sl2r0k 133 3 comparing compare VBG cord-354035-i3sl2r0k 133 4 clinical clinical JJ cord-354035-i3sl2r0k 133 5 tests test NNS cord-354035-i3sl2r0k 133 6 with with IN cord-354035-i3sl2r0k 133 7 HTS HTS NNP cord-354035-i3sl2r0k 133 8 demonstrate demonstrate VBP cord-354035-i3sl2r0k 133 9 that that IN cord-354035-i3sl2r0k 133 10 sequencing sequencing NN cord-354035-i3sl2r0k 133 11 can can MD cord-354035-i3sl2r0k 133 12 add add VB cord-354035-i3sl2r0k 133 13 information information NN cord-354035-i3sl2r0k 133 14 to to IN cord-354035-i3sl2r0k 133 15 clinical clinical JJ cord-354035-i3sl2r0k 133 16 assays assay NNS cord-354035-i3sl2r0k 133 17 in in IN cord-354035-i3sl2r0k 133 18 terms term NNS cord-354035-i3sl2r0k 133 19 of of IN cord-354035-i3sl2r0k 133 20 typing type VBG cord-354035-i3sl2r0k 133 21 viruses virus NNS cord-354035-i3sl2r0k 133 22 and and CC cord-354035-i3sl2r0k 133 23 detecting detect VBG cord-354035-i3sl2r0k 133 24 resistance resistance NN cord-354035-i3sl2r0k 133 25 mutations mutation NNS cord-354035-i3sl2r0k 133 26 . . . cord-354035-i3sl2r0k 134 1 Importantly importantly RB cord-354035-i3sl2r0k 134 2 , , , cord-354035-i3sl2r0k 134 3 they -PRON- PRP cord-354035-i3sl2r0k 134 4 illustrate illustrate VBP cord-354035-i3sl2r0k 134 5 that that IN cord-354035-i3sl2r0k 134 6 viruses virus NNS cord-354035-i3sl2r0k 134 7 not not RB cord-354035-i3sl2r0k 134 8 included include VBN cord-354035-i3sl2r0k 134 9 in in IN cord-354035-i3sl2r0k 134 10 the the DT cord-354035-i3sl2r0k 134 11 PCR PCR NNP cord-354035-i3sl2r0k 134 12 panels panel NNS cord-354035-i3sl2r0k 134 13 are be VBP cord-354035-i3sl2r0k 134 14 sometimes sometimes RB cord-354035-i3sl2r0k 134 15 present present JJ cord-354035-i3sl2r0k 134 16 . . . cord-354035-i3sl2r0k 135 1 In in IN cord-354035-i3sl2r0k 135 2 each each DT cord-354035-i3sl2r0k 135 3 case case NN cord-354035-i3sl2r0k 135 4 , , , cord-354035-i3sl2r0k 135 5 despite despite IN cord-354035-i3sl2r0k 135 6 the the DT cord-354035-i3sl2r0k 135 7 slightly slightly RB cord-354035-i3sl2r0k 135 8 different different JJ cord-354035-i3sl2r0k 135 9 method method NN cord-354035-i3sl2r0k 135 10 used use VBN cord-354035-i3sl2r0k 135 11 for for IN cord-354035-i3sl2r0k 135 12 sample sample NN cord-354035-i3sl2r0k 135 13 collection collection NN cord-354035-i3sl2r0k 135 14 and and CC cord-354035-i3sl2r0k 135 15 preparation preparation NN cord-354035-i3sl2r0k 135 16 and and CC cord-354035-i3sl2r0k 135 17 the the DT cord-354035-i3sl2r0k 135 18 different different JJ cord-354035-i3sl2r0k 135 19 patient patient NN cord-354035-i3sl2r0k 135 20 cohorts cohort NNS cord-354035-i3sl2r0k 135 21 used use VBD cord-354035-i3sl2r0k 135 22 , , , cord-354035-i3sl2r0k 135 23 sensitivity sensitivity NN cord-354035-i3sl2r0k 135 24 for for IN cord-354035-i3sl2r0k 135 25 detection detection NN cord-354035-i3sl2r0k 135 26 was be VBD cord-354035-i3sl2r0k 135 27 an an DT cord-354035-i3sl2r0k 135 28 issue issue NN cord-354035-i3sl2r0k 135 29 . . . cord-354035-i3sl2r0k 136 1 Recently recently RB cord-354035-i3sl2r0k 136 2 2 2 CD cord-354035-i3sl2r0k 136 3 groups group NNS cord-354035-i3sl2r0k 136 4 developed develop VBD cord-354035-i3sl2r0k 136 5 an an DT cord-354035-i3sl2r0k 136 6 approach approach NN cord-354035-i3sl2r0k 136 7 to to TO cord-354035-i3sl2r0k 136 8 enrich enrich VB cord-354035-i3sl2r0k 136 9 viral viral JJ cord-354035-i3sl2r0k 136 10 nucleic nucleic JJ cord-354035-i3sl2r0k 136 11 acids acid NNS cord-354035-i3sl2r0k 136 12 from from IN cord-354035-i3sl2r0k 136 13 a a DT cord-354035-i3sl2r0k 136 14 comprehensive comprehensive JJ cord-354035-i3sl2r0k 136 15 set set NN cord-354035-i3sl2r0k 136 16 of of IN cord-354035-i3sl2r0k 136 17 viruses virus NNS cord-354035-i3sl2r0k 136 18 before before IN cord-354035-i3sl2r0k 136 19 sequencing sequence VBG cord-354035-i3sl2r0k 136 20 . . . cord-354035-i3sl2r0k 137 1 27 27 CD cord-354035-i3sl2r0k 137 2 , , , cord-354035-i3sl2r0k 137 3 28 28 CD cord-354035-i3sl2r0k 138 1 This this DT cord-354035-i3sl2r0k 138 2 approach approach NN cord-354035-i3sl2r0k 138 3 uses use VBZ cord-354035-i3sl2r0k 138 4 targeted target VBN cord-354035-i3sl2r0k 138 5 sequence sequence NN cord-354035-i3sl2r0k 138 6 capture capture NN cord-354035-i3sl2r0k 138 7 , , , cord-354035-i3sl2r0k 138 8 a a DT cord-354035-i3sl2r0k 138 9 hybridization hybridization NN cord-354035-i3sl2r0k 138 10 - - HYPH cord-354035-i3sl2r0k 138 11 based base VBN cord-354035-i3sl2r0k 138 12 approach approach NN cord-354035-i3sl2r0k 138 13 for for IN cord-354035-i3sl2r0k 138 14 selecting select VBG cord-354035-i3sl2r0k 138 15 targets target NNS cord-354035-i3sl2r0k 138 16 of of IN cord-354035-i3sl2r0k 138 17 interest interest NN cord-354035-i3sl2r0k 138 18 . . . cord-354035-i3sl2r0k 139 1 Probes probe NNS cord-354035-i3sl2r0k 139 2 or or CC cord-354035-i3sl2r0k 139 3 baits bait NNS cord-354035-i3sl2r0k 139 4 are be VBP cord-354035-i3sl2r0k 139 5 made make VBN cord-354035-i3sl2r0k 139 6 using use VBG cord-354035-i3sl2r0k 139 7 target target NN cord-354035-i3sl2r0k 139 8 sequences sequence NNS cord-354035-i3sl2r0k 139 9 , , , cord-354035-i3sl2r0k 139 10 and and CC cord-354035-i3sl2r0k 139 11 these these DT cord-354035-i3sl2r0k 139 12 are be VBP cord-354035-i3sl2r0k 139 13 hybridized hybridize VBN cord-354035-i3sl2r0k 139 14 to to IN cord-354035-i3sl2r0k 139 15 the the DT cord-354035-i3sl2r0k 139 16 nucleic nucleic JJ cord-354035-i3sl2r0k 139 17 acid acid NN cord-354035-i3sl2r0k 139 18 in in IN cord-354035-i3sl2r0k 139 19 the the DT cord-354035-i3sl2r0k 139 20 sample sample NN cord-354035-i3sl2r0k 139 21 of of IN cord-354035-i3sl2r0k 139 22 interest interest NN cord-354035-i3sl2r0k 139 23 . . . cord-354035-i3sl2r0k 140 1 The the DT cord-354035-i3sl2r0k 140 2 baits bait NNS cord-354035-i3sl2r0k 140 3 are be VBP cord-354035-i3sl2r0k 140 4 then then RB cord-354035-i3sl2r0k 140 5 captured capture VBN cord-354035-i3sl2r0k 140 6 along along RP cord-354035-i3sl2r0k 140 7 with with IN cord-354035-i3sl2r0k 140 8 the the DT cord-354035-i3sl2r0k 140 9 sequences sequence NNS cord-354035-i3sl2r0k 140 10 that that WDT cord-354035-i3sl2r0k 140 11 hybridized hybridize VBD cord-354035-i3sl2r0k 140 12 to to IN cord-354035-i3sl2r0k 140 13 them -PRON- PRP cord-354035-i3sl2r0k 140 14 and and CC cord-354035-i3sl2r0k 140 15 washed wash VBD cord-354035-i3sl2r0k 140 16 ; ; : cord-354035-i3sl2r0k 140 17 the the DT cord-354035-i3sl2r0k 140 18 result result NN cord-354035-i3sl2r0k 140 19 is be VBZ cord-354035-i3sl2r0k 140 20 an an DT cord-354035-i3sl2r0k 140 21 enrichment enrichment NN cord-354035-i3sl2r0k 140 22 of of IN cord-354035-i3sl2r0k 140 23 the the DT cord-354035-i3sl2r0k 140 24 target target NN cord-354035-i3sl2r0k 140 25 nucleic nucleic JJ cord-354035-i3sl2r0k 140 26 acids acid NNS cord-354035-i3sl2r0k 140 27 in in IN cord-354035-i3sl2r0k 140 28 the the DT cord-354035-i3sl2r0k 140 29 sequencing sequencing NN cord-354035-i3sl2r0k 140 30 assays assay NNS cord-354035-i3sl2r0k 140 31 . . . cord-354035-i3sl2r0k 141 1 These these DT cord-354035-i3sl2r0k 141 2 newly newly RB cord-354035-i3sl2r0k 141 3 developed develop VBN cord-354035-i3sl2r0k 141 4 target target NN cord-354035-i3sl2r0k 141 5 - - HYPH cord-354035-i3sl2r0k 141 6 based base VBN cord-354035-i3sl2r0k 141 7 enrichment enrichment NN cord-354035-i3sl2r0k 141 8 strategies strategy NNS cord-354035-i3sl2r0k 141 9 do do VBP cord-354035-i3sl2r0k 141 10 not not RB cord-354035-i3sl2r0k 141 11 target target VB cord-354035-i3sl2r0k 141 12 specific specific JJ cord-354035-i3sl2r0k 141 13 viruses virus NNS cord-354035-i3sl2r0k 141 14 or or CC cord-354035-i3sl2r0k 141 15 viral viral JJ cord-354035-i3sl2r0k 141 16 families family NNS cord-354035-i3sl2r0k 141 17 that that WDT cord-354035-i3sl2r0k 141 18 are be VBP cord-354035-i3sl2r0k 141 19 expected expect VBN cord-354035-i3sl2r0k 141 20 to to TO cord-354035-i3sl2r0k 141 21 be be VB cord-354035-i3sl2r0k 141 22 associated associate VBN cord-354035-i3sl2r0k 141 23 with with IN cord-354035-i3sl2r0k 141 24 a a DT cord-354035-i3sl2r0k 141 25 disease disease NN cord-354035-i3sl2r0k 141 26 , , , cord-354035-i3sl2r0k 141 27 but but CC cord-354035-i3sl2r0k 141 28 rather rather RB cord-354035-i3sl2r0k 141 29 they -PRON- PRP cord-354035-i3sl2r0k 141 30 include include VBP cord-354035-i3sl2r0k 141 31 targets target NNS cord-354035-i3sl2r0k 141 32 for for IN cord-354035-i3sl2r0k 141 33 all all DT cord-354035-i3sl2r0k 141 34 viruses virus NNS cord-354035-i3sl2r0k 141 35 that that WDT cord-354035-i3sl2r0k 141 36 are be VBP cord-354035-i3sl2r0k 141 37 known know VBN cord-354035-i3sl2r0k 141 38 to to TO cord-354035-i3sl2r0k 141 39 infect infect VB cord-354035-i3sl2r0k 141 40 vertebrates vertebrate NNS cord-354035-i3sl2r0k 141 41 , , , cord-354035-i3sl2r0k 141 42 allowing allow VBG cord-354035-i3sl2r0k 141 43 for for IN cord-354035-i3sl2r0k 141 44 a a DT cord-354035-i3sl2r0k 141 45 comprehensive comprehensive JJ cord-354035-i3sl2r0k 141 46 screen screen NN cord-354035-i3sl2r0k 141 47 of of IN cord-354035-i3sl2r0k 141 48 both both DT cord-354035-i3sl2r0k 141 49 expected expect VBN cord-354035-i3sl2r0k 141 50 and and CC cord-354035-i3sl2r0k 141 51 unexpected unexpected JJ cord-354035-i3sl2r0k 141 52 viruses virus NNS cord-354035-i3sl2r0k 141 53 in in IN cord-354035-i3sl2r0k 141 54 the the DT cord-354035-i3sl2r0k 141 55 same same JJ cord-354035-i3sl2r0k 141 56 assay assay NN cord-354035-i3sl2r0k 141 57 . . . cord-354035-i3sl2r0k 142 1 This this DT cord-354035-i3sl2r0k 142 2 kind kind NN cord-354035-i3sl2r0k 142 3 of of IN cord-354035-i3sl2r0k 142 4 approach approach NN cord-354035-i3sl2r0k 142 5 greatly greatly RB cord-354035-i3sl2r0k 142 6 improves improve VBZ cord-354035-i3sl2r0k 142 7 sequencing sequencing NN cord-354035-i3sl2r0k 142 8 sensitivity sensitivity NN cord-354035-i3sl2r0k 142 9 , , , cord-354035-i3sl2r0k 142 10 with with IN cord-354035-i3sl2r0k 142 11 the the DT cord-354035-i3sl2r0k 142 12 percentage percentage NN cord-354035-i3sl2r0k 142 13 of of IN cord-354035-i3sl2r0k 142 14 viral viral JJ cord-354035-i3sl2r0k 142 15 reads read VBZ cord-354035-i3sl2r0k 142 16 increasing increase VBG cord-354035-i3sl2r0k 142 17 from from IN cord-354035-i3sl2r0k 142 18 approximately approximately RB cord-354035-i3sl2r0k 142 19 10 10 CD cord-354035-i3sl2r0k 142 20 to to IN cord-354035-i3sl2r0k 142 21 approximately approximately RB cord-354035-i3sl2r0k 142 22 10,000 10,000 CD cord-354035-i3sl2r0k 142 23 fold fold NN cord-354035-i3sl2r0k 142 24 using use VBG cord-354035-i3sl2r0k 142 25 targeted target VBN cord-354035-i3sl2r0k 142 26 sequence sequence NN cord-354035-i3sl2r0k 142 27 capture capture NN cord-354035-i3sl2r0k 142 28 compared compare VBN cord-354035-i3sl2r0k 142 29 with with IN cord-354035-i3sl2r0k 142 30 standard standard JJ cord-354035-i3sl2r0k 142 31 HTS HTS NNP cord-354035-i3sl2r0k 142 32 . . . cord-354035-i3sl2r0k 143 1 27 27 CD cord-354035-i3sl2r0k 143 2 , , , cord-354035-i3sl2r0k 143 3 28 28 CD cord-354035-i3sl2r0k 144 1 As as IN cord-354035-i3sl2r0k 144 2 a a DT cord-354035-i3sl2r0k 144 3 result result NN cord-354035-i3sl2r0k 144 4 , , , cord-354035-i3sl2r0k 144 5 virus virus NN cord-354035-i3sl2r0k 144 6 targeted target VBN cord-354035-i3sl2r0k 144 7 sequence sequence NN cord-354035-i3sl2r0k 144 8 capture capture NN cord-354035-i3sl2r0k 144 9 may may MD cord-354035-i3sl2r0k 144 10 be be VB cord-354035-i3sl2r0k 144 11 particularly particularly RB cord-354035-i3sl2r0k 144 12 useful useful JJ cord-354035-i3sl2r0k 144 13 in in IN cord-354035-i3sl2r0k 144 14 helping help VBG cord-354035-i3sl2r0k 144 15 to to TO cord-354035-i3sl2r0k 144 16 diagnose diagnose VB cord-354035-i3sl2r0k 144 17 infections infection NNS cord-354035-i3sl2r0k 144 18 where where WRB cord-354035-i3sl2r0k 144 19 no no DT cord-354035-i3sl2r0k 144 20 virus virus NN cord-354035-i3sl2r0k 144 21 has have VBZ cord-354035-i3sl2r0k 144 22 been be VBN cord-354035-i3sl2r0k 144 23 detected detect VBN cord-354035-i3sl2r0k 144 24 by by IN cord-354035-i3sl2r0k 144 25 routine routine JJ cord-354035-i3sl2r0k 144 26 methods method NNS cord-354035-i3sl2r0k 144 27 . . . cord-354035-i3sl2r0k 145 1 Failures failure NNS cord-354035-i3sl2r0k 145 2 of of IN cord-354035-i3sl2r0k 145 3 routine routine JJ cord-354035-i3sl2r0k 145 4 tests test NNS cord-354035-i3sl2r0k 145 5 occur occur VBP cord-354035-i3sl2r0k 145 6 because because IN cord-354035-i3sl2r0k 145 7 the the DT cord-354035-i3sl2r0k 145 8 virus virus NN cord-354035-i3sl2r0k 145 9 has have VBZ cord-354035-i3sl2r0k 145 10 divergent divergent JJ cord-354035-i3sl2r0k 145 11 sequence sequence NN cord-354035-i3sl2r0k 145 12 from from IN cord-354035-i3sl2r0k 145 13 the the DT cord-354035-i3sl2r0k 145 14 target target NN cord-354035-i3sl2r0k 145 15 in in IN cord-354035-i3sl2r0k 145 16 the the DT cord-354035-i3sl2r0k 145 17 PCR PCR NNP cord-354035-i3sl2r0k 145 18 panel panel NN cord-354035-i3sl2r0k 145 19 , , , cord-354035-i3sl2r0k 145 20 the the DT cord-354035-i3sl2r0k 145 21 virus virus NN cord-354035-i3sl2r0k 145 22 is be VBZ cord-354035-i3sl2r0k 145 23 an an DT cord-354035-i3sl2r0k 145 24 emerging emerge VBG cord-354035-i3sl2r0k 145 25 infectious infectious JJ cord-354035-i3sl2r0k 145 26 disease disease NN cord-354035-i3sl2r0k 145 27 , , , cord-354035-i3sl2r0k 145 28 or or CC cord-354035-i3sl2r0k 145 29 the the DT cord-354035-i3sl2r0k 145 30 virus virus NN cord-354035-i3sl2r0k 145 31 is be VBZ cord-354035-i3sl2r0k 145 32 not not RB cord-354035-i3sl2r0k 145 33 one one CD cord-354035-i3sl2r0k 145 34 of of IN cord-354035-i3sl2r0k 145 35 the the DT cord-354035-i3sl2r0k 145 36 prominent prominent JJ cord-354035-i3sl2r0k 145 37 causes cause NNS cord-354035-i3sl2r0k 145 38 of of IN cord-354035-i3sl2r0k 145 39 respiratory respiratory JJ cord-354035-i3sl2r0k 145 40 infection infection NN cord-354035-i3sl2r0k 145 41 . . . cord-354035-i3sl2r0k 146 1 Interestingly interestingly RB cord-354035-i3sl2r0k 146 2 , , , cord-354035-i3sl2r0k 146 3 sensitive sensitive JJ cord-354035-i3sl2r0k 146 4 molecular molecular JJ cord-354035-i3sl2r0k 146 5 methods method NNS cord-354035-i3sl2r0k 146 6 currently currently RB cord-354035-i3sl2r0k 146 7 used use VBN cord-354035-i3sl2r0k 146 8 for for IN cord-354035-i3sl2r0k 146 9 diagnostics diagnostic NNS cord-354035-i3sl2r0k 146 10 and and CC cord-354035-i3sl2r0k 146 11 many many JJ cord-354035-i3sl2r0k 146 12 research research NN cord-354035-i3sl2r0k 146 13 studies study NNS cord-354035-i3sl2r0k 146 14 demonstrate demonstrate VBP cord-354035-i3sl2r0k 146 15 that that IN cord-354035-i3sl2r0k 146 16 viruses virus NNS cord-354035-i3sl2r0k 146 17 can can MD cord-354035-i3sl2r0k 146 18 frequently frequently RB cord-354035-i3sl2r0k 146 19 be be VB cord-354035-i3sl2r0k 146 20 detected detect VBN cord-354035-i3sl2r0k 146 21 in in IN cord-354035-i3sl2r0k 146 22 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 146 23 individuals individual NNS cord-354035-i3sl2r0k 146 24 . . . cord-354035-i3sl2r0k 147 1 In in IN cord-354035-i3sl2r0k 147 2 the the DT cord-354035-i3sl2r0k 147 3 Utah Utah NNP cord-354035-i3sl2r0k 147 4 study study NN cord-354035-i3sl2r0k 147 5 of of IN cord-354035-i3sl2r0k 147 6 26 26 CD cord-354035-i3sl2r0k 147 7 households household NNS cord-354035-i3sl2r0k 147 8 mentioned mention VBN cord-354035-i3sl2r0k 147 9 earlier early RBR cord-354035-i3sl2r0k 147 10 , , , cord-354035-i3sl2r0k 147 11 bocaviruses bocaviruse NNS cord-354035-i3sl2r0k 147 12 and and CC cord-354035-i3sl2r0k 147 13 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 147 14 could could MD cord-354035-i3sl2r0k 147 15 frequently frequently RB cord-354035-i3sl2r0k 147 16 be be VB cord-354035-i3sl2r0k 147 17 detected detect VBN cord-354035-i3sl2r0k 147 18 in in IN cord-354035-i3sl2r0k 147 19 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 147 20 children child NNS cord-354035-i3sl2r0k 147 21 and and CC cord-354035-i3sl2r0k 147 22 adults adult NNS cord-354035-i3sl2r0k 147 23 . . . cord-354035-i3sl2r0k 148 1 1 1 LS cord-354035-i3sl2r0k 149 1 A a DT cord-354035-i3sl2r0k 149 2 Missouri Missouri NNP cord-354035-i3sl2r0k 149 3 study study NN cord-354035-i3sl2r0k 149 4 that that WDT cord-354035-i3sl2r0k 149 5 used use VBD cord-354035-i3sl2r0k 149 6 both both CC cord-354035-i3sl2r0k 149 7 PCR PCR NNP cord-354035-i3sl2r0k 149 8 assays assay NNS cord-354035-i3sl2r0k 149 9 8 8 CD cord-354035-i3sl2r0k 149 10 and and CC cord-354035-i3sl2r0k 149 11 HTS HTS NNP cord-354035-i3sl2r0k 149 12 9 9 CD cord-354035-i3sl2r0k 149 13 demonstrated demonstrate VBD cord-354035-i3sl2r0k 149 14 that that IN cord-354035-i3sl2r0k 149 15 viral viral JJ cord-354035-i3sl2r0k 149 16 nucleic nucleic JJ cord-354035-i3sl2r0k 149 17 acid acid NN cord-354035-i3sl2r0k 149 18 could could MD cord-354035-i3sl2r0k 149 19 be be VB cord-354035-i3sl2r0k 149 20 detected detect VBN cord-354035-i3sl2r0k 149 21 in in IN cord-354035-i3sl2r0k 149 22 nasopharyngeal nasopharyngeal JJ cord-354035-i3sl2r0k 149 23 swabs swab NNS cord-354035-i3sl2r0k 149 24 from from IN cord-354035-i3sl2r0k 149 25 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 149 26 children child NNS cord-354035-i3sl2r0k 149 27 , , , cord-354035-i3sl2r0k 149 28 in in IN cord-354035-i3sl2r0k 149 29 particular particular JJ cord-354035-i3sl2r0k 149 30 enteroviruses enterovirus NNS cord-354035-i3sl2r0k 149 31 / / SYM cord-354035-i3sl2r0k 149 32 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 149 33 . . . cord-354035-i3sl2r0k 150 1 It -PRON- PRP cord-354035-i3sl2r0k 150 2 is be VBZ cord-354035-i3sl2r0k 150 3 necessary necessary JJ cord-354035-i3sl2r0k 150 4 to to TO cord-354035-i3sl2r0k 150 5 appreciate appreciate VB cord-354035-i3sl2r0k 150 6 that that IN cord-354035-i3sl2r0k 150 7 the the DT cord-354035-i3sl2r0k 150 8 detection detection NN cord-354035-i3sl2r0k 150 9 of of IN cord-354035-i3sl2r0k 150 10 viral viral JJ cord-354035-i3sl2r0k 150 11 nucleic nucleic JJ cord-354035-i3sl2r0k 150 12 acid acid NN cord-354035-i3sl2r0k 150 13 with with IN cord-354035-i3sl2r0k 150 14 molecular molecular JJ cord-354035-i3sl2r0k 150 15 methods method NNS cord-354035-i3sl2r0k 150 16 does do VBZ cord-354035-i3sl2r0k 150 17 not not RB cord-354035-i3sl2r0k 150 18 necessarily necessarily RB cord-354035-i3sl2r0k 150 19 indicate indicate VB cord-354035-i3sl2r0k 150 20 the the DT cord-354035-i3sl2r0k 150 21 virus virus NN cord-354035-i3sl2r0k 150 22 had have VBD cord-354035-i3sl2r0k 150 23 infected infect VBN cord-354035-i3sl2r0k 150 24 the the DT cord-354035-i3sl2r0k 150 25 cell cell NN cord-354035-i3sl2r0k 150 26 and/or and/or CC cord-354035-i3sl2r0k 150 27 was be VBD cord-354035-i3sl2r0k 150 28 successfully successfully RB cord-354035-i3sl2r0k 150 29 replicating replicate VBG cord-354035-i3sl2r0k 150 30 or or CC cord-354035-i3sl2r0k 150 31 that that IN cord-354035-i3sl2r0k 150 32 symptoms symptom NNS cord-354035-i3sl2r0k 150 33 are be VBP cord-354035-i3sl2r0k 150 34 necessarily necessarily RB cord-354035-i3sl2r0k 150 35 resultant resultant JJ cord-354035-i3sl2r0k 150 36 from from IN cord-354035-i3sl2r0k 150 37 the the DT cord-354035-i3sl2r0k 150 38 particular particular JJ cord-354035-i3sl2r0k 150 39 virus virus NN cord-354035-i3sl2r0k 150 40 that that WDT cord-354035-i3sl2r0k 150 41 was be VBD cord-354035-i3sl2r0k 150 42 detected detect VBN cord-354035-i3sl2r0k 150 43 . . . cord-354035-i3sl2r0k 151 1 Additional additional JJ cord-354035-i3sl2r0k 151 2 information information NN cord-354035-i3sl2r0k 151 3 regarding regard VBG cord-354035-i3sl2r0k 151 4 the the DT cord-354035-i3sl2r0k 151 5 host host NN cord-354035-i3sl2r0k 151 6 response response NN cord-354035-i3sl2r0k 151 7 can can MD cord-354035-i3sl2r0k 151 8 be be VB cord-354035-i3sl2r0k 151 9 used use VBN cord-354035-i3sl2r0k 151 10 to to TO cord-354035-i3sl2r0k 151 11 determine determine VB cord-354035-i3sl2r0k 151 12 whether whether IN cord-354035-i3sl2r0k 151 13 symptoms symptom NNS cord-354035-i3sl2r0k 151 14 are be VBP cord-354035-i3sl2r0k 151 15 caused cause VBN cord-354035-i3sl2r0k 151 16 by by IN cord-354035-i3sl2r0k 151 17 viral viral JJ cord-354035-i3sl2r0k 151 18 or or CC cord-354035-i3sl2r0k 151 19 bacterial bacterial JJ cord-354035-i3sl2r0k 151 20 pathogens pathogen NNS cord-354035-i3sl2r0k 151 21 ( ( -LRB- cord-354035-i3sl2r0k 151 22 Fig fig NN cord-354035-i3sl2r0k 151 23 . . NNP cord-354035-i3sl2r0k 151 24 2 2 CD cord-354035-i3sl2r0k 151 25 ) ) -RRB- cord-354035-i3sl2r0k 151 26 . . . cord-354035-i3sl2r0k 152 1 Using use VBG cord-354035-i3sl2r0k 152 2 a a DT cord-354035-i3sl2r0k 152 3 set set NN cord-354035-i3sl2r0k 152 4 of of IN cord-354035-i3sl2r0k 152 5 30 30 CD cord-354035-i3sl2r0k 152 6 samples sample NNS cord-354035-i3sl2r0k 152 7 from from IN cord-354035-i3sl2r0k 152 8 febrile febrile JJ cord-354035-i3sl2r0k 152 9 children child NNS cord-354035-i3sl2r0k 152 10 and and CC cord-354035-i3sl2r0k 152 11 22 22 CD cord-354035-i3sl2r0k 152 12 samples sample NNS cord-354035-i3sl2r0k 152 13 from from IN cord-354035-i3sl2r0k 152 14 afebrile afebrile JJ cord-354035-i3sl2r0k 152 15 controls control NNS cord-354035-i3sl2r0k 152 16 , , , cord-354035-i3sl2r0k 152 17 Hu Hu NNP cord-354035-i3sl2r0k 152 18 and and CC cord-354035-i3sl2r0k 152 19 colleagues colleague NNS cord-354035-i3sl2r0k 152 20 29 29 CD cord-354035-i3sl2r0k 152 21 demonstrated demonstrate VBD cord-354035-i3sl2r0k 152 22 that that IN cord-354035-i3sl2r0k 152 23 there there EX cord-354035-i3sl2r0k 152 24 were be VBD cord-354035-i3sl2r0k 152 25 distinct distinct JJ cord-354035-i3sl2r0k 152 26 host host NN cord-354035-i3sl2r0k 152 27 gene gene NN cord-354035-i3sl2r0k 152 28 expression expression NN cord-354035-i3sl2r0k 152 29 patterns pattern NNS cord-354035-i3sl2r0k 152 30 in in IN cord-354035-i3sl2r0k 152 31 the the DT cord-354035-i3sl2r0k 152 32 blood blood NN cord-354035-i3sl2r0k 152 33 that that WDT cord-354035-i3sl2r0k 152 34 distinguished distinguish VBD cord-354035-i3sl2r0k 152 35 viral viral JJ cord-354035-i3sl2r0k 152 36 and and CC cord-354035-i3sl2r0k 152 37 bacterial bacterial JJ cord-354035-i3sl2r0k 152 38 infections infection NNS cord-354035-i3sl2r0k 152 39 ; ; : cord-354035-i3sl2r0k 152 40 furthermore furthermore RB cord-354035-i3sl2r0k 152 41 , , , cord-354035-i3sl2r0k 152 42 symptomatic symptomatic JJ cord-354035-i3sl2r0k 152 43 and and CC cord-354035-i3sl2r0k 152 44 asymptomatic asymptomatic JJ cord-354035-i3sl2r0k 152 45 infections infection NNS cord-354035-i3sl2r0k 152 46 could could MD cord-354035-i3sl2r0k 152 47 be be VB cord-354035-i3sl2r0k 152 48 clearly clearly RB cord-354035-i3sl2r0k 152 49 delineated delineate VBN cord-354035-i3sl2r0k 152 50 . . . cord-354035-i3sl2r0k 153 1 Similarly similarly RB cord-354035-i3sl2r0k 153 2 , , , cord-354035-i3sl2r0k 153 3 in in IN cord-354035-i3sl2r0k 153 4 118 118 CD cord-354035-i3sl2r0k 153 5 adults adult NNS cord-354035-i3sl2r0k 153 6 with with IN cord-354035-i3sl2r0k 153 7 lower low JJR cord-354035-i3sl2r0k 153 8 respiratory respiratory JJ cord-354035-i3sl2r0k 153 9 tract tract NN cord-354035-i3sl2r0k 153 10 infections infection NNS cord-354035-i3sl2r0k 153 11 and and CC cord-354035-i3sl2r0k 153 12 40 40 CD cord-354035-i3sl2r0k 153 13 healthy healthy JJ cord-354035-i3sl2r0k 153 14 controls control NNS cord-354035-i3sl2r0k 153 15 , , , cord-354035-i3sl2r0k 153 16 host host NN cord-354035-i3sl2r0k 153 17 gene gene NN cord-354035-i3sl2r0k 153 18 expression expression NN cord-354035-i3sl2r0k 153 19 in in IN cord-354035-i3sl2r0k 153 20 the the DT cord-354035-i3sl2r0k 153 21 blood blood NN cord-354035-i3sl2r0k 153 22 could could MD cord-354035-i3sl2r0k 153 23 distinguish distinguish VB cord-354035-i3sl2r0k 153 24 viral viral JJ cord-354035-i3sl2r0k 153 25 and and CC cord-354035-i3sl2r0k 153 26 bacterial bacterial JJ cord-354035-i3sl2r0k 153 27 infections infection NNS cord-354035-i3sl2r0k 153 28 with with IN cord-354035-i3sl2r0k 153 29 95 95 CD cord-354035-i3sl2r0k 153 30 % % NN cord-354035-i3sl2r0k 153 31 sensitivity sensitivity NN cord-354035-i3sl2r0k 153 32 and and CC cord-354035-i3sl2r0k 153 33 92 92 CD cord-354035-i3sl2r0k 153 34 % % NN cord-354035-i3sl2r0k 153 35 specificity specificity NN cord-354035-i3sl2r0k 153 36 . . . cord-354035-i3sl2r0k 154 1 30 30 CD cord-354035-i3sl2r0k 154 2 Bacterial bacterial JJ cord-354035-i3sl2r0k 154 3 - - HYPH cord-354035-i3sl2r0k 154 4 viral viral JJ cord-354035-i3sl2r0k 154 5 coinfections coinfection NNS cord-354035-i3sl2r0k 154 6 could could MD cord-354035-i3sl2r0k 154 7 also also RB cord-354035-i3sl2r0k 154 8 be be VB cord-354035-i3sl2r0k 154 9 distinguished distinguish VBN cord-354035-i3sl2r0k 154 10 . . . cord-354035-i3sl2r0k 155 1 Tsalik Tsalik NNP cord-354035-i3sl2r0k 155 2 and and CC cord-354035-i3sl2r0k 155 3 colleagues colleague NNS cord-354035-i3sl2r0k 155 4 used use VBD cord-354035-i3sl2r0k 155 5 publicly publicly RB cord-354035-i3sl2r0k 155 6 available available JJ cord-354035-i3sl2r0k 155 7 microarray microarray NN cord-354035-i3sl2r0k 155 8 data datum NNS cord-354035-i3sl2r0k 155 9 to to TO cord-354035-i3sl2r0k 155 10 develop develop VB cord-354035-i3sl2r0k 155 11 a a DT cord-354035-i3sl2r0k 155 12 host host NN cord-354035-i3sl2r0k 155 13 gene gene NN cord-354035-i3sl2r0k 155 14 expression expression NN cord-354035-i3sl2r0k 155 15 classifier classifier NN cord-354035-i3sl2r0k 155 16 that that WDT cord-354035-i3sl2r0k 155 17 could could MD cord-354035-i3sl2r0k 155 18 distinguish distinguish VB cord-354035-i3sl2r0k 155 19 bacterial bacterial JJ cord-354035-i3sl2r0k 155 20 , , , cord-354035-i3sl2r0k 155 21 viral viral JJ cord-354035-i3sl2r0k 155 22 , , , cord-354035-i3sl2r0k 155 23 and and CC cord-354035-i3sl2r0k 155 24 noninfectious noninfectious JJ cord-354035-i3sl2r0k 155 25 illnesses illness NNS cord-354035-i3sl2r0k 155 26 with with IN cord-354035-i3sl2r0k 155 27 87 87 CD cord-354035-i3sl2r0k 155 28 % % NN cord-354035-i3sl2r0k 155 29 accuracy accuracy NN cord-354035-i3sl2r0k 155 30 . . . cord-354035-i3sl2r0k 156 1 31 31 CD cord-354035-i3sl2r0k 157 1 Both both DT cord-354035-i3sl2r0k 157 2 the the DT cord-354035-i3sl2r0k 157 3 Suarez Suarez NNP cord-354035-i3sl2r0k 157 4 and and CC cord-354035-i3sl2r0k 157 5 colleagues colleague NNS cord-354035-i3sl2r0k 157 6 30 30 CD cord-354035-i3sl2r0k 157 7 and and CC cord-354035-i3sl2r0k 157 8 Tsalik Tsalik NNP cord-354035-i3sl2r0k 157 9 and and CC cord-354035-i3sl2r0k 157 10 colleagues colleague NNS cord-354035-i3sl2r0k 157 11 studies study NNS cord-354035-i3sl2r0k 157 12 showed show VBD cord-354035-i3sl2r0k 157 13 that that IN cord-354035-i3sl2r0k 157 14 gene gene NN cord-354035-i3sl2r0k 157 15 expression expression NN cord-354035-i3sl2r0k 157 16 profiling profiling NN cord-354035-i3sl2r0k 157 17 performed perform VBN cord-354035-i3sl2r0k 157 18 better well RBR cord-354035-i3sl2r0k 157 19 than than IN cord-354035-i3sl2r0k 157 20 procalcitonin procalcitonin NNS cord-354035-i3sl2r0k 157 21 . . . cord-354035-i3sl2r0k 158 1 In in IN cord-354035-i3sl2r0k 158 2 the the DT cord-354035-i3sl2r0k 158 3 future future NN cord-354035-i3sl2r0k 158 4 , , , cord-354035-i3sl2r0k 158 5 one one PRP cord-354035-i3sl2r0k 158 6 might may MD cord-354035-i3sl2r0k 158 7 imagine imagine VB cord-354035-i3sl2r0k 158 8 that that IN cord-354035-i3sl2r0k 158 9 diagnostics diagnostic NNS cord-354035-i3sl2r0k 158 10 may may MD cord-354035-i3sl2r0k 158 11 couple couple VB cord-354035-i3sl2r0k 158 12 pathogen pathogen NN cord-354035-i3sl2r0k 158 13 detection detection NN cord-354035-i3sl2r0k 158 14 with with IN cord-354035-i3sl2r0k 158 15 host host NN cord-354035-i3sl2r0k 158 16 response response NN cord-354035-i3sl2r0k 158 17 to to TO cord-354035-i3sl2r0k 158 18 provide provide VB cord-354035-i3sl2r0k 158 19 clinicians clinician NNS cord-354035-i3sl2r0k 158 20 clear clear JJ cord-354035-i3sl2r0k 158 21 results result NNS cord-354035-i3sl2r0k 158 22 that that WDT cord-354035-i3sl2r0k 158 23 indicate indicate VBP cord-354035-i3sl2r0k 158 24 whether whether IN cord-354035-i3sl2r0k 158 25 there there EX cord-354035-i3sl2r0k 158 26 is be VBZ cord-354035-i3sl2r0k 158 27 a a DT cord-354035-i3sl2r0k 158 28 need need NN cord-354035-i3sl2r0k 158 29 Fig fig NN cord-354035-i3sl2r0k 158 30 . . NNP cord-354035-i3sl2r0k 158 31 2 2 CD cord-354035-i3sl2r0k 158 32 . . . cord-354035-i3sl2r0k 159 1 Future future JJ cord-354035-i3sl2r0k 159 2 diagnostics diagnostic NNS cord-354035-i3sl2r0k 159 3 . . . cord-354035-i3sl2r0k 160 1 In in IN cord-354035-i3sl2r0k 160 2 the the DT cord-354035-i3sl2r0k 160 3 future future NN cord-354035-i3sl2r0k 160 4 , , , cord-354035-i3sl2r0k 160 5 respiratory respiratory JJ cord-354035-i3sl2r0k 160 6 tract tract NN cord-354035-i3sl2r0k 160 7 infections infection NNS cord-354035-i3sl2r0k 160 8 may may MD cord-354035-i3sl2r0k 160 9 be be VB cord-354035-i3sl2r0k 160 10 diagnosed diagnose VBN cord-354035-i3sl2r0k 160 11 by by IN cord-354035-i3sl2r0k 160 12 merging merge VBG cord-354035-i3sl2r0k 160 13 pathogen pathogen NN cord-354035-i3sl2r0k 160 14 detection detection NN cord-354035-i3sl2r0k 160 15 ( ( -LRB- cord-354035-i3sl2r0k 160 16 the the DT cord-354035-i3sl2r0k 160 17 current current JJ cord-354035-i3sl2r0k 160 18 method method NN cord-354035-i3sl2r0k 160 19 for for IN cord-354035-i3sl2r0k 160 20 diagnostics diagnostic NNS cord-354035-i3sl2r0k 160 21 ) ) -RRB- cord-354035-i3sl2r0k 160 22 with with IN cord-354035-i3sl2r0k 160 23 host host NN cord-354035-i3sl2r0k 160 24 response response NN cord-354035-i3sl2r0k 160 25 measures measure NNS cord-354035-i3sl2r0k 160 26 that that WDT cord-354035-i3sl2r0k 160 27 further further RB cord-354035-i3sl2r0k 160 28 define define VBP cord-354035-i3sl2r0k 160 29 the the DT cord-354035-i3sl2r0k 160 30 cause cause NN cord-354035-i3sl2r0k 160 31 of of IN cord-354035-i3sl2r0k 160 32 the the DT cord-354035-i3sl2r0k 160 33 symptoms symptom NNS cord-354035-i3sl2r0k 160 34 ( ( -LRB- cord-354035-i3sl2r0k 160 35 viral viral JJ cord-354035-i3sl2r0k 160 36 , , , cord-354035-i3sl2r0k 160 37 bacterial bacterial JJ cord-354035-i3sl2r0k 160 38 , , , cord-354035-i3sl2r0k 160 39 coinfections coinfection NNS cord-354035-i3sl2r0k 160 40 , , , cord-354035-i3sl2r0k 160 41 not not RB cord-354035-i3sl2r0k 160 42 pathogenic pathogenic JJ cord-354035-i3sl2r0k 160 43 ) ) -RRB- cord-354035-i3sl2r0k 160 44 . . . cord-354035-i3sl2r0k 161 1 This this DT cord-354035-i3sl2r0k 161 2 merger merger NN cord-354035-i3sl2r0k 161 3 will will MD cord-354035-i3sl2r0k 161 4 help help VB cord-354035-i3sl2r0k 161 5 clarify clarify VB cord-354035-i3sl2r0k 161 6 diagnoses diagnosis NNS cord-354035-i3sl2r0k 161 7 and and CC cord-354035-i3sl2r0k 161 8 define define VB cord-354035-i3sl2r0k 161 9 appropriate appropriate JJ cord-354035-i3sl2r0k 161 10 treatment treatment NN cord-354035-i3sl2r0k 161 11 measures measure NNS cord-354035-i3sl2r0k 161 12 . . . cord-354035-i3sl2r0k 162 1 for for IN cord-354035-i3sl2r0k 162 2 antibiotics antibiotic NNS cord-354035-i3sl2r0k 162 3 in in IN cord-354035-i3sl2r0k 162 4 each each DT cord-354035-i3sl2r0k 162 5 case case NN cord-354035-i3sl2r0k 162 6 . . . cord-354035-i3sl2r0k 163 1 In in IN cord-354035-i3sl2r0k 163 2 fact fact NN cord-354035-i3sl2r0k 163 3 , , , cord-354035-i3sl2r0k 163 4 approaches approach VBZ cord-354035-i3sl2r0k 163 5 that that IN cord-354035-i3sl2r0k 163 6 couple couple NN cord-354035-i3sl2r0k 163 7 pathogen pathogen NN cord-354035-i3sl2r0k 163 8 detection detection NN cord-354035-i3sl2r0k 163 9 and and CC cord-354035-i3sl2r0k 163 10 host host NN cord-354035-i3sl2r0k 163 11 response response NN cord-354035-i3sl2r0k 163 12 are be VBP cord-354035-i3sl2r0k 163 13 being be VBG cord-354035-i3sl2r0k 163 14 put put VBN cord-354035-i3sl2r0k 163 15 forth forth RP cord-354035-i3sl2r0k 163 16 as as RB cord-354035-i3sl2r0k 163 17 highly highly RB cord-354035-i3sl2r0k 163 18 effective effective JJ cord-354035-i3sl2r0k 163 19 diagnostic diagnostic JJ cord-354035-i3sl2r0k 163 20 approach approach NN cord-354035-i3sl2r0k 163 21 ; ; : cord-354035-i3sl2r0k 163 22 software software NN cord-354035-i3sl2r0k 163 23 tools tool NNS cord-354035-i3sl2r0k 163 24 are be VBP cord-354035-i3sl2r0k 163 25 being be VBG cord-354035-i3sl2r0k 163 26 developed develop VBN cord-354035-i3sl2r0k 163 27 to to TO cord-354035-i3sl2r0k 163 28 rapidly rapidly RB cord-354035-i3sl2r0k 163 29 provide provide VB cord-354035-i3sl2r0k 163 30 reports report NNS cord-354035-i3sl2r0k 163 31 that that WDT cord-354035-i3sl2r0k 163 32 may may MD cord-354035-i3sl2r0k 163 33 in in IN cord-354035-i3sl2r0k 163 34 the the DT cord-354035-i3sl2r0k 163 35 very very RB cord-354035-i3sl2r0k 163 36 near near JJ cord-354035-i3sl2r0k 163 37 future future NN cord-354035-i3sl2r0k 163 38 be be VB cord-354035-i3sl2r0k 163 39 used use VBN cord-354035-i3sl2r0k 163 40 by by IN cord-354035-i3sl2r0k 163 41 clinicians clinician NNS cord-354035-i3sl2r0k 163 42 for for IN cord-354035-i3sl2r0k 163 43 diagnostic diagnostic JJ cord-354035-i3sl2r0k 163 44 purposes purpose NNS cord-354035-i3sl2r0k 163 45 . . . cord-354035-i3sl2r0k 164 1 32 32 CD cord-354035-i3sl2r0k 164 2 _SP cord-354035-i3sl2r0k 165 1 We -PRON- PRP cord-354035-i3sl2r0k 165 2 are be VBP cord-354035-i3sl2r0k 165 3 beginning begin VBG cord-354035-i3sl2r0k 165 4 to to TO cord-354035-i3sl2r0k 165 5 define define VB cord-354035-i3sl2r0k 165 6 the the DT cord-354035-i3sl2r0k 165 7 scope scope NN cord-354035-i3sl2r0k 165 8 of of IN cord-354035-i3sl2r0k 165 9 the the DT cord-354035-i3sl2r0k 165 10 human human JJ cord-354035-i3sl2r0k 165 11 respiratory respiratory JJ cord-354035-i3sl2r0k 165 12 tract tract NN cord-354035-i3sl2r0k 165 13 virome virome NN cord-354035-i3sl2r0k 165 14 . . . cord-354035-i3sl2r0k 166 1 The the DT cord-354035-i3sl2r0k 166 2 prevalence prevalence NN cord-354035-i3sl2r0k 166 3 of of IN cord-354035-i3sl2r0k 166 4 individual individual JJ cord-354035-i3sl2r0k 166 5 viruses virus NNS cord-354035-i3sl2r0k 166 6 vary vary VBP cord-354035-i3sl2r0k 166 7 from from IN cord-354035-i3sl2r0k 166 8 study study NN cord-354035-i3sl2r0k 166 9 to to TO cord-354035-i3sl2r0k 166 10 study study VB cord-354035-i3sl2r0k 166 11 ( ( -LRB- cord-354035-i3sl2r0k 166 12 see see VB cord-354035-i3sl2r0k 166 13 Table Table NNP cord-354035-i3sl2r0k 166 14 1 1 CD cord-354035-i3sl2r0k 166 15 ) ) -RRB- cord-354035-i3sl2r0k 166 16 , , , cord-354035-i3sl2r0k 166 17 likely likely RB cord-354035-i3sl2r0k 166 18 due due IN cord-354035-i3sl2r0k 166 19 to to IN cord-354035-i3sl2r0k 166 20 differences difference NNS cord-354035-i3sl2r0k 166 21 in in IN cord-354035-i3sl2r0k 166 22 seasonality seasonality NN cord-354035-i3sl2r0k 166 23 of of IN cord-354035-i3sl2r0k 166 24 sample sample NN cord-354035-i3sl2r0k 166 25 collection collection NN cord-354035-i3sl2r0k 166 26 , , , cord-354035-i3sl2r0k 166 27 variation variation NN cord-354035-i3sl2r0k 166 28 in in IN cord-354035-i3sl2r0k 166 29 local local JJ cord-354035-i3sl2r0k 166 30 virus virus NN cord-354035-i3sl2r0k 166 31 circulation circulation NN cord-354035-i3sl2r0k 166 32 , , , cord-354035-i3sl2r0k 166 33 and and CC cord-354035-i3sl2r0k 166 34 methodological methodological JJ cord-354035-i3sl2r0k 166 35 choices choice NNS cord-354035-i3sl2r0k 166 36 ( ( -LRB- cord-354035-i3sl2r0k 166 37 eg eg UH cord-354035-i3sl2r0k 166 38 , , , cord-354035-i3sl2r0k 166 39 sample sample NN cord-354035-i3sl2r0k 166 40 type type NN cord-354035-i3sl2r0k 166 41 , , , cord-354035-i3sl2r0k 166 42 sample sample NN cord-354035-i3sl2r0k 166 43 preparation preparation NN cord-354035-i3sl2r0k 166 44 ) ) -RRB- cord-354035-i3sl2r0k 166 45 . . . cord-354035-i3sl2r0k 167 1 The the DT cord-354035-i3sl2r0k 167 2 studies study NNS cord-354035-i3sl2r0k 167 3 reviewed review VBN cord-354035-i3sl2r0k 167 4 here here RB cord-354035-i3sl2r0k 167 5 demonstrate demonstrate VBP cord-354035-i3sl2r0k 167 6 that that IN cord-354035-i3sl2r0k 167 7 HTS HTS NNP cord-354035-i3sl2r0k 167 8 and and CC cord-354035-i3sl2r0k 167 9 expanded expand VBN cord-354035-i3sl2r0k 167 10 panels panel NNS cord-354035-i3sl2r0k 167 11 of of IN cord-354035-i3sl2r0k 167 12 PCR PCR NNP cord-354035-i3sl2r0k 167 13 assays assay NNS cord-354035-i3sl2r0k 167 14 can can MD cord-354035-i3sl2r0k 167 15 identify identify VB cord-354035-i3sl2r0k 167 16 rare rare JJ cord-354035-i3sl2r0k 167 17 viral viral JJ cord-354035-i3sl2r0k 167 18 pathogens pathogen NNS cord-354035-i3sl2r0k 167 19 that that WDT cord-354035-i3sl2r0k 167 20 might may MD cord-354035-i3sl2r0k 167 21 not not RB cord-354035-i3sl2r0k 167 22 be be VB cord-354035-i3sl2r0k 167 23 included include VBN cord-354035-i3sl2r0k 167 24 in in IN cord-354035-i3sl2r0k 167 25 multiplex multiplex JJ cord-354035-i3sl2r0k 167 26 diagnostic diagnostic JJ cord-354035-i3sl2r0k 167 27 panels panel NNS cord-354035-i3sl2r0k 167 28 or or CC cord-354035-i3sl2r0k 167 29 PCR PCR NNP cord-354035-i3sl2r0k 167 30 panels panel NNS cord-354035-i3sl2r0k 167 31 in in IN cord-354035-i3sl2r0k 167 32 which which WDT cord-354035-i3sl2r0k 167 33 only only RB cord-354035-i3sl2r0k 167 34 the the DT cord-354035-i3sl2r0k 167 35 most most RBS cord-354035-i3sl2r0k 167 36 common common JJ cord-354035-i3sl2r0k 167 37 pathogens pathogen NNS cord-354035-i3sl2r0k 167 38 or or CC cord-354035-i3sl2r0k 167 39 viruses virus NNS cord-354035-i3sl2r0k 167 40 of of IN cord-354035-i3sl2r0k 167 41 interest interest NN cord-354035-i3sl2r0k 167 42 are be VBP cord-354035-i3sl2r0k 167 43 selected select VBN cord-354035-i3sl2r0k 167 44 . . . cord-354035-i3sl2r0k 168 1 The the DT cord-354035-i3sl2r0k 168 2 relatively relatively RB cord-354035-i3sl2r0k 168 3 unbiased unbiased JJ cord-354035-i3sl2r0k 168 4 sequencing sequencing NN cord-354035-i3sl2r0k 168 5 approach approach NN cord-354035-i3sl2r0k 168 6 can can MD cord-354035-i3sl2r0k 168 7 also also RB cord-354035-i3sl2r0k 168 8 reveal reveal VB cord-354035-i3sl2r0k 168 9 viruses virus NNS cord-354035-i3sl2r0k 168 10 that that WDT cord-354035-i3sl2r0k 168 11 may may MD cord-354035-i3sl2r0k 168 12 not not RB cord-354035-i3sl2r0k 168 13 directly directly RB cord-354035-i3sl2r0k 168 14 cause cause VB cord-354035-i3sl2r0k 168 15 respiratory respiratory JJ cord-354035-i3sl2r0k 168 16 illness illness NN cord-354035-i3sl2r0k 168 17 but but CC cord-354035-i3sl2r0k 168 18 whose whose WP$ cord-354035-i3sl2r0k 168 19 presence presence NN cord-354035-i3sl2r0k 168 20 may may MD cord-354035-i3sl2r0k 168 21 impact impact VB cord-354035-i3sl2r0k 168 22 the the DT cord-354035-i3sl2r0k 168 23 trajectory trajectory NN cord-354035-i3sl2r0k 168 24 of of IN cord-354035-i3sl2r0k 168 25 illness illness NN cord-354035-i3sl2r0k 168 26 through through IN cord-354035-i3sl2r0k 168 27 mechanisms mechanism NNS cord-354035-i3sl2r0k 168 28 we -PRON- PRP cord-354035-i3sl2r0k 168 29 do do VBP cord-354035-i3sl2r0k 168 30 not not RB cord-354035-i3sl2r0k 168 31 yet yet RB cord-354035-i3sl2r0k 168 32 understand understand VB cord-354035-i3sl2r0k 168 33 . . . cord-354035-i3sl2r0k 169 1 Methodological methodological JJ cord-354035-i3sl2r0k 169 2 improvements improvement NNS cord-354035-i3sl2r0k 169 3 to to IN cord-354035-i3sl2r0k 169 4 virus virus NN cord-354035-i3sl2r0k 169 5 detection detection NN cord-354035-i3sl2r0k 169 6 will will MD cord-354035-i3sl2r0k 169 7 help help VB cord-354035-i3sl2r0k 169 8 us -PRON- PRP cord-354035-i3sl2r0k 169 9 better better RB cord-354035-i3sl2r0k 169 10 define define VB cord-354035-i3sl2r0k 169 11 the the DT cord-354035-i3sl2r0k 169 12 respiratory respiratory JJ cord-354035-i3sl2r0k 169 13 tract tract NN cord-354035-i3sl2r0k 169 14 virome virome NN cord-354035-i3sl2r0k 169 15 and and CC cord-354035-i3sl2r0k 169 16 monitor monitor VB cord-354035-i3sl2r0k 169 17 outbreaks outbreak NNS cord-354035-i3sl2r0k 169 18 . . . cord-354035-i3sl2r0k 170 1 In in IN cord-354035-i3sl2r0k 170 2 the the DT cord-354035-i3sl2r0k 170 3 future future NN cord-354035-i3sl2r0k 170 4 , , , cord-354035-i3sl2r0k 170 5 clinical clinical JJ cord-354035-i3sl2r0k 170 6 tests test NNS cord-354035-i3sl2r0k 170 7 may may MD cord-354035-i3sl2r0k 170 8 include include VB cord-354035-i3sl2r0k 170 9 both both DT cord-354035-i3sl2r0k 170 10 pathogen pathogen NN cord-354035-i3sl2r0k 170 11 detection detection NN cord-354035-i3sl2r0k 170 12 and and CC cord-354035-i3sl2r0k 170 13 an an DT cord-354035-i3sl2r0k 170 14 assessment assessment NN cord-354035-i3sl2r0k 170 15 of of IN cord-354035-i3sl2r0k 170 16 host host NN cord-354035-i3sl2r0k 170 17 response response NN cord-354035-i3sl2r0k 170 18 in in IN cord-354035-i3sl2r0k 170 19 order order NN cord-354035-i3sl2r0k 170 20 to to TO cord-354035-i3sl2r0k 170 21 more more RBR cord-354035-i3sl2r0k 170 22 clearly clearly RB cord-354035-i3sl2r0k 170 23 distinguish distinguish VB cord-354035-i3sl2r0k 170 24 viral viral JJ cord-354035-i3sl2r0k 170 25 and and CC cord-354035-i3sl2r0k 170 26 bacterial bacterial JJ cord-354035-i3sl2r0k 170 27 infections infection NNS cord-354035-i3sl2r0k 170 28 . . . cord-354035-i3sl2r0k 171 1 Community community NN cord-354035-i3sl2r0k 171 2 surveillance surveillance NN cord-354035-i3sl2r0k 171 3 of of IN cord-354035-i3sl2r0k 171 4 respiratory respiratory JJ cord-354035-i3sl2r0k 171 5 viruses virus NNS cord-354035-i3sl2r0k 171 6 among among IN cord-354035-i3sl2r0k 171 7 families family NNS cord-354035-i3sl2r0k 171 8 in in IN cord-354035-i3sl2r0k 171 9 the the DT cord-354035-i3sl2r0k 171 10 Utah Utah NNP cord-354035-i3sl2r0k 171 11 better well JJR cord-354035-i3sl2r0k 171 12 identification identification NN cord-354035-i3sl2r0k 171 13 of of IN cord-354035-i3sl2r0k 171 14 germslongitudinal germslongitudinal JJ cord-354035-i3sl2r0k 171 15 viral viral JJ cord-354035-i3sl2r0k 171 16 epidemiology epidemiology NN cord-354035-i3sl2r0k 172 1 ( ( -LRB- cord-354035-i3sl2r0k 172 2 BIG big JJ cord-354035-i3sl2r0k 172 3 - - HYPH cord-354035-i3sl2r0k 172 4 LoVE love NN cord-354035-i3sl2r0k 172 5 ) ) -RRB- cord-354035-i3sl2r0k 172 6 study study NN cord-354035-i3sl2r0k 172 7 Studies Studies NNPS cord-354035-i3sl2r0k 172 8 of of IN cord-354035-i3sl2r0k 172 9 the the DT cord-354035-i3sl2r0k 172 10 community community NN cord-354035-i3sl2r0k 172 11 and and CC cord-354035-i3sl2r0k 172 12 family family NN cord-354035-i3sl2r0k 172 13 : : : cord-354035-i3sl2r0k 172 14 acute acute JJ cord-354035-i3sl2r0k 172 15 respiratory respiratory JJ cord-354035-i3sl2r0k 172 16 illness illness NN cord-354035-i3sl2r0k 172 17 and and CC cord-354035-i3sl2r0k 172 18 infection infection NN cord-354035-i3sl2r0k 172 19 Case Case NNP cord-354035-i3sl2r0k 172 20 studies study NNS cord-354035-i3sl2r0k 172 21 of of IN cord-354035-i3sl2r0k 172 22 the the DT cord-354035-i3sl2r0k 172 23 spatial spatial JJ cord-354035-i3sl2r0k 172 24 heterogeneity heterogeneity NN cord-354035-i3sl2r0k 172 25 of of IN cord-354035-i3sl2r0k 172 26 DNA dna NN cord-354035-i3sl2r0k 172 27 viruses virus NNS cord-354035-i3sl2r0k 172 28 in in IN cord-354035-i3sl2r0k 172 29 the the DT cord-354035-i3sl2r0k 172 30 cystic cystic JJ cord-354035-i3sl2r0k 172 31 fibrosis fibrosis NN cord-354035-i3sl2r0k 172 32 lung lung NNP cord-354035-i3sl2r0k 172 33 Characterization characterization NN cord-354035-i3sl2r0k 172 34 of of IN cord-354035-i3sl2r0k 172 35 the the DT cord-354035-i3sl2r0k 172 36 viral viral JJ cord-354035-i3sl2r0k 172 37 microbiome microbiome NN cord-354035-i3sl2r0k 172 38 in in IN cord-354035-i3sl2r0k 172 39 patients patient NNS cord-354035-i3sl2r0k 172 40 with with IN cord-354035-i3sl2r0k 172 41 severe severe JJ cord-354035-i3sl2r0k 172 42 lower low JJR cord-354035-i3sl2r0k 172 43 respiratory respiratory JJ cord-354035-i3sl2r0k 172 44 tract tract NN cord-354035-i3sl2r0k 172 45 infections infection NNS cord-354035-i3sl2r0k 172 46 , , , cord-354035-i3sl2r0k 172 47 using use VBG cord-354035-i3sl2r0k 172 48 metagenomic metagenomic NN cord-354035-i3sl2r0k 172 49 sequencing sequencing NN cord-354035-i3sl2r0k 172 50 . . . cord-354035-i3sl2r0k 173 1 Highlander Highlander NNP cord-354035-i3sl2r0k 173 2 SK SK NNP cord-354035-i3sl2r0k 173 3 Metagenomic Metagenomic NNP cord-354035-i3sl2r0k 173 4 analysis analysis NN cord-354035-i3sl2r0k 173 5 of of IN cord-354035-i3sl2r0k 173 6 viral viral JJ cord-354035-i3sl2r0k 173 7 genetic genetic JJ cord-354035-i3sl2r0k 173 8 diversity diversity NN cord-354035-i3sl2r0k 173 9 in in IN cord-354035-i3sl2r0k 173 10 respiratory respiratory JJ cord-354035-i3sl2r0k 173 11 samples sample NNS cord-354035-i3sl2r0k 173 12 from from IN cord-354035-i3sl2r0k 173 13 children child NNS cord-354035-i3sl2r0k 173 14 with with IN cord-354035-i3sl2r0k 173 15 severe severe JJ cord-354035-i3sl2r0k 173 16 acute acute JJ cord-354035-i3sl2r0k 173 17 respiratory respiratory JJ cord-354035-i3sl2r0k 173 18 infection infection NN cord-354035-i3sl2r0k 173 19 in in IN cord-354035-i3sl2r0k 173 20 China China NNP cord-354035-i3sl2r0k 173 21 Communityacquired Communityacquired NNP cord-354035-i3sl2r0k 173 22 pneumonia pneumonia NN cord-354035-i3sl2r0k 173 23 among among IN cord-354035-i3sl2r0k 173 24 U.S. U.S. NNP cord-354035-i3sl2r0k 173 25 children child NNS cord-354035-i3sl2r0k 173 26 Community Community NNP cord-354035-i3sl2r0k 173 27 - - HYPH cord-354035-i3sl2r0k 173 28 acquired acquire VBN cord-354035-i3sl2r0k 173 29 pneumonia pneumonia NN cord-354035-i3sl2r0k 173 30 requiring require VBG cord-354035-i3sl2r0k 173 31 hospitalization hospitalization NN cord-354035-i3sl2r0k 173 32 among among IN cord-354035-i3sl2r0k 173 33 U.S. U.S. NNP cord-354035-i3sl2r0k 173 34 adults adult NNS cord-354035-i3sl2r0k 173 35 Detection Detection NNP cord-354035-i3sl2r0k 173 36 of of IN cord-354035-i3sl2r0k 173 37 viruses virus NNS cord-354035-i3sl2r0k 173 38 in in IN cord-354035-i3sl2r0k 173 39 young young JJ cord-354035-i3sl2r0k 173 40 children child NNS cord-354035-i3sl2r0k 173 41 with with IN cord-354035-i3sl2r0k 173 42 fever fever NN cord-354035-i3sl2r0k 173 43 without without IN cord-354035-i3sl2r0k 173 44 an an DT cord-354035-i3sl2r0k 173 45 apparent apparent JJ cord-354035-i3sl2r0k 173 46 source source NN cord-354035-i3sl2r0k 173 47 Sequence sequence NN cord-354035-i3sl2r0k 173 48 analysis analysis NN cord-354035-i3sl2r0k 173 49 of of IN cord-354035-i3sl2r0k 173 50 the the DT cord-354035-i3sl2r0k 173 51 human human JJ cord-354035-i3sl2r0k 173 52 virome virome NN cord-354035-i3sl2r0k 173 53 in in IN cord-354035-i3sl2r0k 173 54 febrile febrile JJ cord-354035-i3sl2r0k 173 55 and and CC cord-354035-i3sl2r0k 173 56 afebrile afebrile JJ cord-354035-i3sl2r0k 173 57 children child NNS cord-354035-i3sl2r0k 173 58 Increased increase VBD cord-354035-i3sl2r0k 173 59 prevalence prevalence NN cord-354035-i3sl2r0k 173 60 of of IN cord-354035-i3sl2r0k 173 61 anellovirus anellovirus NN cord-354035-i3sl2r0k 173 62 in in IN cord-354035-i3sl2r0k 173 63 pediatric pediatric JJ cord-354035-i3sl2r0k 173 64 patients patient NNS cord-354035-i3sl2r0k 173 65 with with IN cord-354035-i3sl2r0k 173 66 fever fever NN cord-354035-i3sl2r0k 173 67 Digging dig VBG cord-354035-i3sl2r0k 173 68 through through IN cord-354035-i3sl2r0k 173 69 the the DT cord-354035-i3sl2r0k 173 70 obstruction obstruction NN cord-354035-i3sl2r0k 173 71 : : : cord-354035-i3sl2r0k 173 72 insight insight NN cord-354035-i3sl2r0k 173 73 into into IN cord-354035-i3sl2r0k 173 74 the the DT cord-354035-i3sl2r0k 173 75 epithelial epithelial JJ cord-354035-i3sl2r0k 173 76 cell cell NN cord-354035-i3sl2r0k 173 77 response response NN cord-354035-i3sl2r0k 173 78 to to IN cord-354035-i3sl2r0k 173 79 respiratory respiratory JJ cord-354035-i3sl2r0k 173 80 virus virus NN cord-354035-i3sl2r0k 173 81 infection infection NN cord-354035-i3sl2r0k 173 82 in in IN cord-354035-i3sl2r0k 173 83 patients patient NNS cord-354035-i3sl2r0k 173 84 with with IN cord-354035-i3sl2r0k 173 85 cystic cystic JJ cord-354035-i3sl2r0k 173 86 fibrosis fibrosis NN cord-354035-i3sl2r0k 174 1 The the DT cord-354035-i3sl2r0k 174 2 role role NN cord-354035-i3sl2r0k 174 3 of of IN cord-354035-i3sl2r0k 174 4 viral viral JJ cord-354035-i3sl2r0k 174 5 infections infection NNS cord-354035-i3sl2r0k 174 6 in in IN cord-354035-i3sl2r0k 174 7 exacerbations exacerbation NNS cord-354035-i3sl2r0k 174 8 of of IN cord-354035-i3sl2r0k 174 9 chronic chronic JJ cord-354035-i3sl2r0k 174 10 obstructive obstructive JJ cord-354035-i3sl2r0k 174 11 pulmonary pulmonary JJ cord-354035-i3sl2r0k 174 12 disease disease NN cord-354035-i3sl2r0k 174 13 and and CC cord-354035-i3sl2r0k 174 14 asthma asthma NN cord-354035-i3sl2r0k 174 15 Incidence incidence NN cord-354035-i3sl2r0k 174 16 and and CC cord-354035-i3sl2r0k 174 17 clinical clinical JJ cord-354035-i3sl2r0k 174 18 impact impact NN cord-354035-i3sl2r0k 174 19 of of IN cord-354035-i3sl2r0k 174 20 respiratory respiratory JJ cord-354035-i3sl2r0k 174 21 viruses virus NNS cord-354035-i3sl2r0k 174 22 in in IN cord-354035-i3sl2r0k 174 23 adults adult NNS cord-354035-i3sl2r0k 174 24 with with IN cord-354035-i3sl2r0k 174 25 cystic cystic JJ cord-354035-i3sl2r0k 174 26 fibrosis fibrosis NN cord-354035-i3sl2r0k 174 27 Virus Virus NNP cord-354035-i3sl2r0k 174 28 and and CC cord-354035-i3sl2r0k 174 29 cystic cystic JJ cord-354035-i3sl2r0k 174 30 fibrosis fibrosis NN cord-354035-i3sl2r0k 174 31 : : : cord-354035-i3sl2r0k 174 32 rhinoviruses rhinovirus NNS cord-354035-i3sl2r0k 174 33 are be VBP cord-354035-i3sl2r0k 174 34 associated associate VBN cord-354035-i3sl2r0k 174 35 with with IN cord-354035-i3sl2r0k 174 36 exacerbations exacerbation NNS cord-354035-i3sl2r0k 174 37 in in IN cord-354035-i3sl2r0k 174 38 adult adult NN cord-354035-i3sl2r0k 174 39 patients patient NNS cord-354035-i3sl2r0k 175 1 The the DT cord-354035-i3sl2r0k 175 2 role role NN cord-354035-i3sl2r0k 175 3 of of IN cord-354035-i3sl2r0k 175 4 respiratory respiratory JJ cord-354035-i3sl2r0k 175 5 viruses virus NNS cord-354035-i3sl2r0k 175 6 in in IN cord-354035-i3sl2r0k 175 7 cystic cystic JJ cord-354035-i3sl2r0k 175 8 fibrosis fibrosis NN cord-354035-i3sl2r0k 175 9 Metagenomic Metagenomic NNP cord-354035-i3sl2r0k 175 10 analysis analysis NN cord-354035-i3sl2r0k 175 11 of of IN cord-354035-i3sl2r0k 175 12 respiratory respiratory JJ cord-354035-i3sl2r0k 175 13 tract tract NN cord-354035-i3sl2r0k 175 14 DNA dna NN cord-354035-i3sl2r0k 175 15 viral viral JJ cord-354035-i3sl2r0k 175 16 communities community NNS cord-354035-i3sl2r0k 175 17 in in IN cord-354035-i3sl2r0k 175 18 cystic cystic JJ cord-354035-i3sl2r0k 175 19 fibrosis fibrosis NN cord-354035-i3sl2r0k 175 20 and and CC cord-354035-i3sl2r0k 176 1 non non JJ cord-354035-i3sl2r0k 176 2 - - JJ cord-354035-i3sl2r0k 176 3 cystic cystic JJ cord-354035-i3sl2r0k 176 4 fibrosis fibrosis NN cord-354035-i3sl2r0k 176 5 individuals individual NNS cord-354035-i3sl2r0k 176 6 Viral viral JJ cord-354035-i3sl2r0k 176 7 metagenomics metagenomic NNS cord-354035-i3sl2r0k 176 8 reveal reveal VBP cord-354035-i3sl2r0k 176 9 blooms bloom NNS cord-354035-i3sl2r0k 176 10 of of IN cord-354035-i3sl2r0k 176 11 anelloviruses anelloviruse NNS cord-354035-i3sl2r0k 176 12 in in IN cord-354035-i3sl2r0k 176 13 the the DT cord-354035-i3sl2r0k 176 14 respiratory respiratory JJ cord-354035-i3sl2r0k 176 15 tract tract NN cord-354035-i3sl2r0k 176 16 of of IN cord-354035-i3sl2r0k 176 17 lung lung NN cord-354035-i3sl2r0k 176 18 transplant transplant NN cord-354035-i3sl2r0k 176 19 recipients recipient NNS cord-354035-i3sl2r0k 177 1 Temporal temporal JJ cord-354035-i3sl2r0k 177 2 response response NN cord-354035-i3sl2r0k 177 3 of of IN cord-354035-i3sl2r0k 177 4 the the DT cord-354035-i3sl2r0k 177 5 human human JJ cord-354035-i3sl2r0k 177 6 virome virome NN cord-354035-i3sl2r0k 177 7 to to IN cord-354035-i3sl2r0k 177 8 immunosuppression immunosuppression NN cord-354035-i3sl2r0k 177 9 and and CC cord-354035-i3sl2r0k 177 10 antiviral antiviral JJ cord-354035-i3sl2r0k 177 11 therapy therapy NN cord-354035-i3sl2r0k 177 12 Viral Viral NNP cord-354035-i3sl2r0k 177 13 discovery discovery NN cord-354035-i3sl2r0k 177 14 and and CC cord-354035-i3sl2r0k 177 15 sequence sequence NN cord-354035-i3sl2r0k 177 16 recovery recovery NN cord-354035-i3sl2r0k 177 17 using use VBG cord-354035-i3sl2r0k 177 18 DNA dna NN cord-354035-i3sl2r0k 177 19 microarrays microarray NNS cord-354035-i3sl2r0k 177 20 Identification identification NN cord-354035-i3sl2r0k 177 21 of of IN cord-354035-i3sl2r0k 177 22 new new JJ cord-354035-i3sl2r0k 177 23 respiratory respiratory JJ cord-354035-i3sl2r0k 177 24 viruses virus NNS cord-354035-i3sl2r0k 177 25 in in IN cord-354035-i3sl2r0k 177 26 the the DT cord-354035-i3sl2r0k 177 27 new new JJ cord-354035-i3sl2r0k 177 28 millennium millennium NN cord-354035-i3sl2r0k 177 29 . . . cord-354035-i3sl2r0k 178 1 Viruses virus NNS cord-354035-i3sl2r0k 178 2 Emerging emerge VBG cord-354035-i3sl2r0k 178 3 influenza influenza NN cord-354035-i3sl2r0k 178 4 strains strain NNS cord-354035-i3sl2r0k 178 5 in in IN cord-354035-i3sl2r0k 178 6 the the DT cord-354035-i3sl2r0k 178 7 last last JJ cord-354035-i3sl2r0k 178 8 two two CD cord-354035-i3sl2r0k 178 9 decades decade NNS cord-354035-i3sl2r0k 178 10 : : : cord-354035-i3sl2r0k 178 11 a a DT cord-354035-i3sl2r0k 178 12 threat threat NN cord-354035-i3sl2r0k 178 13 of of IN cord-354035-i3sl2r0k 178 14 a a DT cord-354035-i3sl2r0k 178 15 new new JJ cord-354035-i3sl2r0k 178 16 pandemic pandemic NN cord-354035-i3sl2r0k 178 17 ? ? . cord-354035-i3sl2r0k 179 1 Genome genome NN cord-354035-i3sl2r0k 179 2 sequence sequence NN cord-354035-i3sl2r0k 179 3 of of IN cord-354035-i3sl2r0k 179 4 enterovirus enterovirus NN cord-354035-i3sl2r0k 179 5 D68 D68 NNP cord-354035-i3sl2r0k 179 6 from from IN cord-354035-i3sl2r0k 179 7 St St NNP cord-354035-i3sl2r0k 179 8 Louis Louis NNP cord-354035-i3sl2r0k 179 9 Development Development NNP cord-354035-i3sl2r0k 179 10 and and CC cord-354035-i3sl2r0k 179 11 evaluation evaluation NN cord-354035-i3sl2r0k 179 12 of of IN cord-354035-i3sl2r0k 179 13 an an DT cord-354035-i3sl2r0k 179 14 enterovirus enterovirus NN cord-354035-i3sl2r0k 179 15 D68 D68 NNP cord-354035-i3sl2r0k 179 16 real real JJ cord-354035-i3sl2r0k 179 17 - - HYPH cord-354035-i3sl2r0k 179 18 time time NN cord-354035-i3sl2r0k 179 19 reverse reverse NN cord-354035-i3sl2r0k 179 20 transcriptase transcriptase NN cord-354035-i3sl2r0k 179 21 PCR pcr NN cord-354035-i3sl2r0k 179 22 assay assay NN cord-354035-i3sl2r0k 179 23 Unbiased unbiased JJ cord-354035-i3sl2r0k 179 24 detection detection NN cord-354035-i3sl2r0k 179 25 of of IN cord-354035-i3sl2r0k 179 26 respiratory respiratory JJ cord-354035-i3sl2r0k 179 27 viruses virus NNS cord-354035-i3sl2r0k 179 28 by by IN cord-354035-i3sl2r0k 179 29 use use NN cord-354035-i3sl2r0k 179 30 of of IN cord-354035-i3sl2r0k 179 31 RNA RNA NNP cord-354035-i3sl2r0k 179 32 sequencing sequencing NN cord-354035-i3sl2r0k 179 33 - - HYPH cord-354035-i3sl2r0k 179 34 based base VBN cord-354035-i3sl2r0k 179 35 metagenomics metagenomic NNS cord-354035-i3sl2r0k 179 36 : : : cord-354035-i3sl2r0k 179 37 a a DT cord-354035-i3sl2r0k 179 38 systematic systematic JJ cord-354035-i3sl2r0k 179 39 comparison comparison NN cord-354035-i3sl2r0k 179 40 to to IN cord-354035-i3sl2r0k 179 41 a a DT cord-354035-i3sl2r0k 179 42 commercial commercial JJ cord-354035-i3sl2r0k 179 43 PCR PCR NNP cord-354035-i3sl2r0k 179 44 panel panel NN cord-354035-i3sl2r0k 180 1 The the DT cord-354035-i3sl2r0k 180 2 use use NN cord-354035-i3sl2r0k 180 3 of of IN cord-354035-i3sl2r0k 180 4 next next JJ cord-354035-i3sl2r0k 180 5 generation generation NN cord-354035-i3sl2r0k 180 6 sequencing sequencing NN cord-354035-i3sl2r0k 180 7 in in IN cord-354035-i3sl2r0k 180 8 the the DT cord-354035-i3sl2r0k 180 9 diagnosis diagnosis NN cord-354035-i3sl2r0k 180 10 and and CC cord-354035-i3sl2r0k 180 11 typing typing NN cord-354035-i3sl2r0k 180 12 of of IN cord-354035-i3sl2r0k 180 13 respiratory respiratory JJ cord-354035-i3sl2r0k 180 14 infections infection NNS cord-354035-i3sl2r0k 180 15 Direct direct JJ cord-354035-i3sl2r0k 180 16 multiplexed multiplexed JJ cord-354035-i3sl2r0k 180 17 whole whole JJ cord-354035-i3sl2r0k 180 18 genome genome NN cord-354035-i3sl2r0k 180 19 sequencing sequencing NN cord-354035-i3sl2r0k 180 20 of of IN cord-354035-i3sl2r0k 180 21 respiratory respiratory JJ cord-354035-i3sl2r0k 180 22 tract tract NN cord-354035-i3sl2r0k 180 23 samples sample NNS cord-354035-i3sl2r0k 180 24 reveals reveal VBZ cord-354035-i3sl2r0k 180 25 full full JJ cord-354035-i3sl2r0k 180 26 viral viral JJ cord-354035-i3sl2r0k 180 27 genomic genomic JJ cord-354035-i3sl2r0k 180 28 information information NN cord-354035-i3sl2r0k 181 1 Enhanced enhanced JJ cord-354035-i3sl2r0k 181 2 virome virome NN cord-354035-i3sl2r0k 181 3 sequencing sequencing NN cord-354035-i3sl2r0k 181 4 using use VBG cord-354035-i3sl2r0k 181 5 targeted target VBN cord-354035-i3sl2r0k 181 6 sequence sequence NN cord-354035-i3sl2r0k 181 7 capture capture NN cord-354035-i3sl2r0k 181 8 Virome Virome NNP cord-354035-i3sl2r0k 181 9 capture capture NN cord-354035-i3sl2r0k 181 10 sequencing sequencing NN cord-354035-i3sl2r0k 181 11 enables enable VBZ cord-354035-i3sl2r0k 181 12 sensitive sensitive JJ cord-354035-i3sl2r0k 181 13 viral viral JJ cord-354035-i3sl2r0k 181 14 diagnosis diagnosis NN cord-354035-i3sl2r0k 181 15 and and CC cord-354035-i3sl2r0k 181 16 comprehensive comprehensive JJ cord-354035-i3sl2r0k 181 17 virome virome NN cord-354035-i3sl2r0k 181 18 analysis analysis NN cord-354035-i3sl2r0k 181 19 Gene Gene NNP cord-354035-i3sl2r0k 181 20 expression expression NN cord-354035-i3sl2r0k 181 21 profiles profile NNS cord-354035-i3sl2r0k 181 22 in in IN cord-354035-i3sl2r0k 181 23 febrile febrile JJ cord-354035-i3sl2r0k 181 24 children child NNS cord-354035-i3sl2r0k 181 25 with with IN cord-354035-i3sl2r0k 181 26 defined define VBN cord-354035-i3sl2r0k 181 27 viral viral JJ cord-354035-i3sl2r0k 181 28 and and CC cord-354035-i3sl2r0k 181 29 bacterial bacterial JJ cord-354035-i3sl2r0k 181 30 infection infection NN cord-354035-i3sl2r0k 181 31 Superiority superiority NN cord-354035-i3sl2r0k 181 32 of of IN cord-354035-i3sl2r0k 181 33 transcriptional transcriptional JJ cord-354035-i3sl2r0k 181 34 profiling profiling NN cord-354035-i3sl2r0k 181 35 over over IN cord-354035-i3sl2r0k 181 36 procalcitonin procalcitonin NNS cord-354035-i3sl2r0k 181 37 for for IN cord-354035-i3sl2r0k 181 38 distinguishing distinguish VBG cord-354035-i3sl2r0k 181 39 bacterial bacterial NN cord-354035-i3sl2r0k 181 40 from from IN cord-354035-i3sl2r0k 181 41 viral viral JJ cord-354035-i3sl2r0k 181 42 lower low JJR cord-354035-i3sl2r0k 181 43 respiratory respiratory JJ cord-354035-i3sl2r0k 181 44 tract tract NN cord-354035-i3sl2r0k 181 45 infections infection NNS cord-354035-i3sl2r0k 181 46 in in IN cord-354035-i3sl2r0k 181 47 hospitalized hospitalize VBN cord-354035-i3sl2r0k 181 48 adults adult NNS cord-354035-i3sl2r0k 181 49 Host Host NNP cord-354035-i3sl2r0k 181 50 gene gene NN cord-354035-i3sl2r0k 181 51 expression expression NN cord-354035-i3sl2r0k 181 52 classifiers classifier NNS cord-354035-i3sl2r0k 181 53 diagnose diagnose VBP cord-354035-i3sl2r0k 182 1 acute acute JJ cord-354035-i3sl2r0k 182 2 respiratory respiratory JJ cord-354035-i3sl2r0k 182 3 illness illness NN cord-354035-i3sl2r0k 182 4 etiology etiology NN cord-354035-i3sl2r0k 182 5 Taxonomer Taxonomer NNP cord-354035-i3sl2r0k 182 6 : : : cord-354035-i3sl2r0k 182 7 an an DT cord-354035-i3sl2r0k 182 8 interactive interactive JJ cord-354035-i3sl2r0k 182 9 metagenomics metagenomics NN cord-354035-i3sl2r0k 182 10 analysis analysis NN cord-354035-i3sl2r0k 182 11 portal portal NNP cord-354035-i3sl2r0k 182 12 for for IN cord-354035-i3sl2r0k 182 13 universal universal JJ cord-354035-i3sl2r0k 182 14 pathogen pathogen NN cord-354035-i3sl2r0k 182 15 detection detection NN cord-354035-i3sl2r0k 182 16 and and CC cord-354035-i3sl2r0k 182 17 host host NN cord-354035-i3sl2r0k 182 18 mRNA mRNA NNP cord-354035-i3sl2r0k 182 19 expression expression NN cord-354035-i3sl2r0k 182 20 profiling profiling NN