id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352894-88c46evj	Yoon, Soon‐Seek	Comparison of the diagnostic methods on the canine adenovirus type 2 infection	2010-06-02		.txt	text/plain	2573	152	46	Methods: Stray dog samples were evaluated by histopathology, polymerase chain reaction (PCR), and immunohistochemistry (IHC) to investigate the status of the CAV‐2 infection on the stray dogs in Korea. Common infectious causes of respiratory disease in dogs include canine distemper virus (CDV) and canine adenovirus type 2 (CAV-2). 3 Pulmonary CAV-2 lesions are consistent with those of bronchointerstitial pneumonia, including the presence of necrosis and large basophilic intranuclear inclusion bodies (IN/IBs) in bronchiolar and alveolar epithelial cells as well as pulmonary macrophages. 5,6 Therefore, pneumonic lung tissues were examined for CAV-2 antigen by immunochemistry and CAV-2 genes by polymerase chain reaction (PCR) in the present study. 5 CAV-2 specific IC/IBs were identified in only three cases in the present study; however, seven cases were IHC positive for CAV-2 antigen detection. These results suggested that CAV-2 particles may fail to create detectable inclusions in some cases although viral antigens were present in the lung tissues.	./cache/cord-352894-88c46evj.txt	./txt/cord-352894-88c46evj.txt