id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335393-4buooi2d	Xiang, Yangxi	Comparative transcriptome analysis reveals the role of p53 signalling pathway during red‐spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells	2019-01-18		.txt	text/plain	3887	221	46	title: Comparative transcriptome analysis reveals the role of p53 signalling pathway during red‐spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells To better comprehend the molecular immune mechanism of sea perch (Lateolabrax japonicus) against NNV infection, the comparative transcriptome analysis of red‐spotted grouper nervous necrosis virus (RGNNV)‐infected or mock‐infected L. Based on the analysis of differentially expressed genes (DEGs), we found that p53 signalling pathway might be involved in the immune response against RGNNV, and experimentally revealed the role of L. Of these genes, many well-known immune-related genes were strongly inhibited after RGNNV infecComparative transcriptome analysis showed that 79 DEGs involved in p53 signalling pathway were regulated in RGNNV-infected LJB cells compared to control cells (Supporting Information Figure S1 ). Several studies indicated that p53 functioned as a key player in innate antiviral immunity by both enforcing the type I IFN response and inducing apoptosis in virus-infected cells (Rivas, Aaronson, & Munoz-Fontela, 2010) .	./cache/cord-335393-4buooi2d.txt	./txt/cord-335393-4buooi2d.txt