id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306682-01q775up	Vijgen, Leen	Identification of six new polymorphisms in the human coronavirus 229E receptor gene (aminopeptidase N/CD13)()	2004-06-22		.txt	text/plain	2965	166	54	In this study we examined whether polymorphisms could be detected in the HCoV-229E binding domain of APN in a Caucasian population of 100 unrelated, healthy individuals, assuming that these mutations could be of importance in HCoV-229E attachment to human cells. A total of 100 healthy unrelated Belgian individuals were screened for polymorphisms in the human aminopeptidase N domain that is essential for its HCoV-229E receptor activity. All individuals were heterozygous for these polymorphisms, which have no apparent functional consequence, as they are located in a non-coding intron region of the APN gene. In our search for polymorphisms in the APN domain that is essential for its HCoV-229E receptor function, we identified seven polymorphisms, of which four were located in the non-coding intron 3. Three polymorphisms in APN exon 4 (C956T, G978T and G987A) in association with an intron 3 variation (C389T), were identified at a relatively high allele frequency (8.5%) in our Belgian population.	./cache/cord-306682-01q775up.txt	./txt/cord-306682-01q775up.txt